PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3878789-4 1985 Treatment of Raji cells with rabbit anti-gp140 blocked the uptake of three 125I-labeled monoclonal antibodies anti-B2, HB-5 and OKB7 reported to react with C3d-binding proteins, indicating that each of these monoclonal antibodies recognizes epitopes present on gp140. Iodine-125 75-79 endogenous retrovirus group K member 13 Homo sapiens 156-159 31721030-5 2020 Preadipocytes that were treated with polychlorinated biphenyl congener 126 (PCB126), followed by differentiation, were suppressed for their ability to activate UCP1 upon beta-adrenergic stimulation with norepinephrine (NE), demonstrating a block in the beiging response. Norepinephrine 203-217 uncoupling protein 1 Homo sapiens 160-164 20435076-4 2010 They contain noradrenaline, but subsets of these neurons also express prolactin-releasing peptide acting synergistically with noradrenaline in the activation of the hypothalamic paraventricular nucleus during stress. Norepinephrine 126-139 prolactin releasing hormone Rattus norvegicus 70-97 31811856-3 2020 Noradrenaline increased alpha1B-adrenergic receptor-Rab5 interaction, which was blocked by paroxetine and by expression of the dominant-negative GRK2 mutant. Norepinephrine 0-13 RAB5A, member RAS oncogene family Homo sapiens 52-56 31707103-5 2020 These results raise the possibility that inflammation-mediated beta2-adrenoceptor downregulation in glia may dampen the innate anti-inflammatory properties of noradrenaline in the CNS. Norepinephrine 159-172 adrenoceptor beta 2 Rattus norvegicus 63-81 31891756-4 2019 It was hypothesised that NAT would be expressed exclusively on nerve fibres labelled by dopamine beta hydroxylase (DbetaH), an enzyme involved in the conversion of dopamine to noradrenaline. Norepinephrine 176-189 dopamine beta-hydroxylase Rattus norvegicus 88-113 31799519-0 2019 Critical nucleus of Greek-key-like core of alpha-synuclein protofibril and its disruption by dopamine and norepinephrine. Norepinephrine 106-120 synuclein alpha Homo sapiens 43-58 31183808-5 2019 Only norepinephrine seemed to also modulate subliminal conflict processing, as evidenced by better performance of the DBH rs1611122 CC genotype in case of high subliminal conflict load. Norepinephrine 5-19 dopamine beta-hydroxylase Homo sapiens 118-121 31445965-6 2019 Site selective stimulation of the SMG induced the release of norepinephrine, resulting in beta2AR dependent acetylcholine release in the MLN and spleen. Norepinephrine 61-75 adenosine A2a receptor Homo sapiens 90-97 20650329-7 2010 We found that DSP-4 treatment depleted the expression of the norepinephrine marker dopamine -hydroxylase (DBH) in the locus coeruleus and its projection area, the basolateral nucleus of the amygdala, confirming locus coeruleus noradrenergic lesion in the experimental animals. Norepinephrine 61-75 dopamine beta-hydroxylase Rattus norvegicus 106-109 20170659-7 2010 Short interfering RNA targeting XBP1 suppressed the induction of BNP expression by a pharmacological ER stressor or norepinephrine, which was rescued by the adenovirus-mediated overexpression of sXBP1. Norepinephrine 116-130 X-box binding protein 1 Homo sapiens 32-36 31484844-3 2019 More recently, we have revealed that a selective eEF2K inhibitor, A484954 induced vasorelaxation via opening inward rectifier K+ channel and activating beta2-adrenergic receptor in smooth muscle of rat isolated mesenteric artery, which contributes to prevent noradrenaline-induced acute increase in blood pressure (BP). Norepinephrine 259-272 eukaryotic elongation factor-2 kinase Rattus norvegicus 49-54 32259069-2 2019 One strategy to mitigate the SNS overdrive is by restricting the biosynthesis of norepinephrine via the inhibition of dopamine beta-hydroxylase (DBH). Norepinephrine 81-95 dopamine beta-hydroxylase Rattus norvegicus 118-143 20086041-12 2010 Interestingly, KL-shRNA increased brain ET1 expression and plasma norepinephrine level, suggesting that silencing of brain klotho increased ET1 production and the sympathetic nervous activity. Norepinephrine 66-80 Klotho Rattus norvegicus 123-129 32259069-2 2019 One strategy to mitigate the SNS overdrive is by restricting the biosynthesis of norepinephrine via the inhibition of dopamine beta-hydroxylase (DBH). Norepinephrine 81-95 dopamine beta-hydroxylase Rattus norvegicus 145-148 32259069-3 2019 Zamicastat is a new DBH inhibitor that decreases norepinephrine and increases dopamine levels in peripherally sympathetic-innervated tissues. Norepinephrine 49-63 dopamine beta-hydroxylase Rattus norvegicus 20-23 32259069-13 2019 In conclusion, DBH inhibition decreased norepinephrine levels, reduced end-organ damage, and improved cardiometabolic and inflammatory biomarkers in aged male SHRs. Norepinephrine 40-54 dopamine beta-hydroxylase Rattus norvegicus 15-18 30882962-3 2019 The present review has summarized the currently available pre-clinical and clinical data on the interactions of CB1 and cannabinoid type-2 receptors (CB2 ) with the central neurotransmitters; dopamine, serotonin, noradrenaline, GABA, glutamate and opioids. Norepinephrine 213-226 cannabinoid receptor 2 Homo sapiens 150-153 31009605-7 2019 PDE4 inhibition increased noradrenaline potency in wild type and AC5 KO, but not AC6 KO. Norepinephrine 26-39 adenylate cyclase 5 Mus musculus 65-68 20035031-6 2010 Isoproterenol-induced coronary vasodilation was mediated through the beta(2)-adrenoceptor, whereas norepinephrine-induced coronary vasodilation was principally mediated through the beta(1)-adrenoceptor. Norepinephrine 99-113 adrenoceptor beta 1 Sus scrofa 181-201 31009605-9 2019 PDE3 inhibition increased noradrenaline potency only in AC5 KO that was treated prior with PTX. Norepinephrine 26-39 adenylate cyclase 5 Mus musculus 56-59 31156340-8 2019 The areas under the curves for the renalase-dopamine, renalase-norepinephrine and renalase-epinephrine ratios were 0.805, 95% confidence interval (CI): 0.699-0.912 (p<0.001); 0.726, 95% CI: 0.594-0.859 (p=0.032); and 0.656, 95% CI: 0.520-0.791 (p=0.02). Norepinephrine 63-77 renalase, FAD dependent amine oxidase Homo sapiens 54-62 19757024-2 2010 Synthesis of norepinephrine from dopamine is catalyzed by the enzyme dopamine beta-hydroxylase and numerous polymorphisms in the DBH gene have been found to exert their direct influence on the enzyme activity independently. Norepinephrine 13-27 dopamine beta-hydroxylase Homo sapiens 69-94 19757024-2 2010 Synthesis of norepinephrine from dopamine is catalyzed by the enzyme dopamine beta-hydroxylase and numerous polymorphisms in the DBH gene have been found to exert their direct influence on the enzyme activity independently. Norepinephrine 13-27 dopamine beta-hydroxylase Homo sapiens 129-132 19932741-7 2010 By contrast, in the raphe region of Mecp2-null mice, there were significant decreases in 5-HT and noradrenaline levels, but these differences later disappeared and there was no change in the number of 5-HT-immunoreactive neuronal cell bodies. Norepinephrine 98-111 methyl CpG binding protein 2 Mus musculus 36-41 19890267-1 2010 Reversible inhibitors of monoamine oxidase-A (RIMA) inhibit the breakdown of three major neurotransmitters, serotonin, norepinephrine and dopamine, offering a multi-neurotransmitter strategy for the treatment of depression. Norepinephrine 119-133 monoamine oxidase A Homo sapiens 25-44 19910432-1 2009 UNLABELLED: The histamine H(3) receptor is a G-protein-coupled presynaptic auto- and heteroreceptor whose activation leads to a decrease in the release of several neurotransmitters including histamine, acetycholine, noradrenaline, and dopamine. Norepinephrine 216-229 histamine receptor H3 Homo sapiens 16-39 19388884-10 2009 We also measured extracellular glutamate and norepinephrine concentration in hippocampal CA1 in the four groups. Norepinephrine 45-59 carbonic anhydrase 1 Rattus norvegicus 89-92 31156340-8 2019 The areas under the curves for the renalase-dopamine, renalase-norepinephrine and renalase-epinephrine ratios were 0.805, 95% confidence interval (CI): 0.699-0.912 (p<0.001); 0.726, 95% CI: 0.594-0.859 (p=0.032); and 0.656, 95% CI: 0.520-0.791 (p=0.02). Norepinephrine 63-77 renalase, FAD dependent amine oxidase Homo sapiens 54-62 29498170-1 2019 The alpha1 -adrenergic antagonist, doxazosin, has improved cocaine use disorder (CUD) presumably by blocking norepinephrine (NE) stimulation and reward from cocaine-induced NE increases. Norepinephrine 109-123 adrenoceptor alpha 1D Homo sapiens 4-10 31035382-5 2019 Presence of Hif2alpha resulted in similarly increased cellular dopamine and norepinephrine under hypoxia as in the control cells. Norepinephrine 76-90 endothelial PAS domain protein 1 Homo sapiens 12-21 19713945-0 2009 S100B modulates the hemodynamic response to norepinephrine stimulation. Norepinephrine 44-58 S100 protein, beta polypeptide, neural Mus musculus 0-5 19713945-1 2009 BACKGROUND: We have previously reported that S100B acts as an intrinsic negative regulator of the myocardial hypertrophic response to norepinephrine (NE). Norepinephrine 134-148 S100 protein, beta polypeptide, neural Mus musculus 45-50 19079842-1 2009 Cu is an essential cofactor for at least twelve mammalian enzymes including dopamine beta-mono-oxygenase (DBM), which converts dopamine (DA) to noradrenaline (NA). Norepinephrine 144-157 dopamine beta-hydroxylase Rattus norvegicus 76-104 19345680-4 2009 In particular, noradrenaline (NA) is required for late-LTP in the dentate gyrus and dopamine for late-LTP in the apical CA1-dendrites. Norepinephrine 15-28 carbonic anhydrase 1 Rattus norvegicus 120-123 19038360-4 2009 It was observed that cell preincubation with insulin, IGF-I, EGF or PDGF markedly reduced the intracellular calcium increase observed in response to noradrenaline. Norepinephrine 149-162 insulin-like growth factor 1 Rattus norvegicus 54-59 19038360-4 2009 It was observed that cell preincubation with insulin, IGF-I, EGF or PDGF markedly reduced the intracellular calcium increase observed in response to noradrenaline. Norepinephrine 149-162 epidermal growth factor Rattus norvegicus 61-64 19046481-9 2009 In contrast, in vitro exposure of cultured glial cells to noradrenaline suppressed IL-1beta, TNF-alpha, iNOS and CD40 expression. Norepinephrine 58-71 CD40 molecule Rattus norvegicus 113-117 30852703-4 2019 Finally, the density of monoamine oxidase-A (MAO-A), a mitochondrial enzyme that degrades 5-HT, norepinephrine, and dopamine (DA), was reported as lower in the OFC and ventral striatum of ASPD. Norepinephrine 96-110 monoamine oxidase A Homo sapiens 24-43 19374850-12 2009 These results suggest that centrally administered epibatidine activates the brain nicotinic acethylcholine receptors, thereby evoking the secretion of noradrenaline and adrenaline from the adrenal medulla by brain cyclooxygenase- and prostanoid TP receptor-mediated mechanisms in rats. Norepinephrine 151-164 thromboxane A2 receptor Rattus norvegicus 214-256 19212675-2 2009 By microarray expression analysis (Affymetrix HU133A) important players in the noradrenalin biosynthesis pathway (DBH, DDC, GATA2, GATA3, PHOX2A, PHOX2B, SLC6A2 SLC18A1 and TH) were found to be among the top ranked genes in showing lower expression in unfavorable NB tumor types as compared to favorable ones. Norepinephrine 79-91 dopamine beta-hydroxylase Homo sapiens 114-117 18849110-0 2009 The inhibitory effect of norepinephrine on the migration of ES-2 ovarian carcinoma cells involves a Rap1-dependent pathway. Norepinephrine 25-39 RAP1A, member of RAS oncogene family Homo sapiens 100-104 19236326-4 2009 Also, we found that NO released from hypothalamic NOergic neurons in response to norepinephrine diffuses to luteinizing hormone-releasing hormone (LHRH) neurons that activate cyclooxygenase and guanylate cyclase. Norepinephrine 81-95 gonadotropin releasing hormone 1 Rattus norvegicus 108-145 19236326-4 2009 Also, we found that NO released from hypothalamic NOergic neurons in response to norepinephrine diffuses to luteinizing hormone-releasing hormone (LHRH) neurons that activate cyclooxygenase and guanylate cyclase. Norepinephrine 81-95 gonadotropin releasing hormone 1 Rattus norvegicus 147-151 30852703-4 2019 Finally, the density of monoamine oxidase-A (MAO-A), a mitochondrial enzyme that degrades 5-HT, norepinephrine, and dopamine (DA), was reported as lower in the OFC and ventral striatum of ASPD. Norepinephrine 96-110 monoamine oxidase A Homo sapiens 45-50 30759385-0 2019 Age- and alpha-Synuclein-Dependent Degeneration of Dopamine and Noradrenaline Neurons in the Annual Killifish Nothobranchius furzeri. Norepinephrine 64-77 synuclein alpha Homo sapiens 9-24 29685068-4 2019 Animal models, particularly mouse models carrying variants of AD-related gene(s), many of which lead to an accumulation of Abeta, suggest that a fundamental shift in depression-related monoaminergic systems (including serotonin and noradrenaline) is a strong indicator of the altered cellular function associated with the earlier(est) stages of AD-related pathology. Norepinephrine 232-245 amyloid beta (A4) precursor protein Mus musculus 123-128 31029854-10 2019 Doxycycline-induced tetNGN3-HIEs secreted serotonin, monocyte chemoattractant protein-1, glucose-dependent insulinotropic peptide, peptide YY, and ghrelin in response to norepinephrine and rotavirus infection, further supporting the presence of multiple EEC types. Norepinephrine 170-184 C-C motif chemokine ligand 2 Homo sapiens 53-87 18982239-1 2009 Dopamine-beta-hydroxylase (DbetaH) catalyzes the conversion of dopamine to norepinephrine in central noradrenergic and adrenergic neurons and thus is critically involved in the biosynthesis of catecholamines. Norepinephrine 75-89 dopamine beta-hydroxylase Homo sapiens 0-25 19038969-6 2009 Combined activation of insulin-like growth factor 1 and epidermal growth factor receptors was particularly notable for antagonistic interactions at some levels of signal transduction and norepinephrine production, but potentiation at other levels of signaling and cytoprotection. Norepinephrine 187-201 epidermal growth factor Homo sapiens 56-79 30341172-4 2018 Dopamine is converted to norepinephrine by dopamine-beta-hydroxylase (DBH), which acquires its essential Cu cofactor from ATP7A. Norepinephrine 25-39 dopamine beta-hydroxylase Homo sapiens 43-68 18973765-2 2009 The balance of dopamine and noradrenaline in the cortex is controlled by the DBH gene. Norepinephrine 28-41 dopamine beta-hydroxylase Homo sapiens 77-80 19212441-3 2009 Phagocytes isolated from adrenalectomized rats displayed enhanced expression of tyrosine-hydroxylase and dopamine-beta-hydroxylase, two key enzymes for catecholamine production and exhibited higher baseline secretion of norepinephrine and epinephrine. Norepinephrine 220-234 dopamine beta-hydroxylase Rattus norvegicus 105-130 19020050-5 2008 Conversely, the transfection of synthetic anti-miR oligonucleotides that inhibit miR-338 increases COXIV levels, and results in a significant increase in oxidative phosphorylation and also norepinephrine uptake in the axons. Norepinephrine 189-203 microRNA 338 Homo sapiens 81-88 18706965-0 2008 Antimicrobial action of histone H2B in Escherichia coli: evidence for membrane translocation and DNA-binding of a histone H2B fragment after proteolytic cleavage by outer membrane proteinase T. Previous studies have led to the isolation of histone H2B with antibacterial properties from an extract of the skin of the Schlegel"s green tree frog Rhacophorus schlegelii and it is now demonstrated that the intact peptide is released into norepinephrine-stimulated skin secretions. Norepinephrine 435-449 H2B clustered histone 21 Homo sapiens 32-35 18706965-0 2008 Antimicrobial action of histone H2B in Escherichia coli: evidence for membrane translocation and DNA-binding of a histone H2B fragment after proteolytic cleavage by outer membrane proteinase T. Previous studies have led to the isolation of histone H2B with antibacterial properties from an extract of the skin of the Schlegel"s green tree frog Rhacophorus schlegelii and it is now demonstrated that the intact peptide is released into norepinephrine-stimulated skin secretions. Norepinephrine 435-449 H2B clustered histone 21 Homo sapiens 122-125 18706965-0 2008 Antimicrobial action of histone H2B in Escherichia coli: evidence for membrane translocation and DNA-binding of a histone H2B fragment after proteolytic cleavage by outer membrane proteinase T. Previous studies have led to the isolation of histone H2B with antibacterial properties from an extract of the skin of the Schlegel"s green tree frog Rhacophorus schlegelii and it is now demonstrated that the intact peptide is released into norepinephrine-stimulated skin secretions. Norepinephrine 435-449 H2B clustered histone 21 Homo sapiens 122-125 30341172-4 2018 Dopamine is converted to norepinephrine by dopamine-beta-hydroxylase (DBH), which acquires its essential Cu cofactor from ATP7A. Norepinephrine 25-39 dopamine beta-hydroxylase Homo sapiens 70-73 30271325-1 2018 Monoamine oxidase A (MAO-A) is an enzyme that regulates the levels of monoamine neurotransmitters, such as serotonin, noradrenaline and dopamine and it has been used as a therapeutic target for depression. Norepinephrine 118-131 monoamine oxidase A Homo sapiens 0-19 18762182-3 2008 Dexamethasone and norepinephrine administered separately oppositely affected differentiation of human neuroblastoma SH-SY5Y cells, observed by both morphological alterations and gene expression, at the level of mRNA and protein of the differentiation markers Gap-43, L1 and laminin. Norepinephrine 18-32 growth associated protein 43 Homo sapiens 259-265 18722504-1 2008 Local application of alphabetaMeATP (ligand for P2X3 receptors) and capsaicin (ligand for TRPV1 receptors) to the rat hindpaw produces pain behaviors (flinching) which are enhanced by noradrenaline (NA). Norepinephrine 184-197 purinergic receptor P2X 3 Rattus norvegicus 48-52 30271325-1 2018 Monoamine oxidase A (MAO-A) is an enzyme that regulates the levels of monoamine neurotransmitters, such as serotonin, noradrenaline and dopamine and it has been used as a therapeutic target for depression. Norepinephrine 118-131 monoamine oxidase A Homo sapiens 21-26 18361446-1 2008 Monoamine oxidase A (MAOA) is an enzyme expressed in the brain that metabolizes dopamine, norepinephrine, epinephrine, and serotonin. Norepinephrine 90-104 monoamine oxidase A Homo sapiens 0-19 18361446-1 2008 Monoamine oxidase A (MAOA) is an enzyme expressed in the brain that metabolizes dopamine, norepinephrine, epinephrine, and serotonin. Norepinephrine 90-104 monoamine oxidase A Homo sapiens 21-25 29987109-2 2018 NPY (neuropeptide Y) is coreleased with norepinephrine, causes vasoconstriction via the Y1 receptor, and is degraded by DPP4 to NPY (3-36) in vitro. Norepinephrine 40-54 neuropeptide Y Homo sapiens 0-3 18800308-4 2008 An intracerebroventricular injection of leptin attenuated the increases in hypothalamic noradrenaline release and plasma ACTH concentrations after FSs, while ghrelin augmented these responses. Norepinephrine 88-101 leptin Homo sapiens 40-46 18800308-5 2008 These data suggest that leptin inhibits and ghrelin facilitates neuroendocrine stress responses via noradrenaline release and indicate that a decrease in leptin and an increase in ghrelin release after food deprivation might contribute to augmentation of stress-induced ACTH release in a fasting state. Norepinephrine 100-113 leptin Homo sapiens 24-30 18572378-2 2008 Their spatial and temporal expression at the neural crest is instrumental in determining neuronal precursor fate, and by regulating DbetaH expression, the enzyme catalysing noradrenaline synthesis from dopamine, they also play a role in determination of noradrenergic phenotype. Norepinephrine 173-186 dopamine beta-hydroxylase Homo sapiens 132-138 29987109-2 2018 NPY (neuropeptide Y) is coreleased with norepinephrine, causes vasoconstriction via the Y1 receptor, and is degraded by DPP4 to NPY (3-36) in vitro. Norepinephrine 40-54 neuropeptide Y Homo sapiens 5-19 29987109-3 2018 NPY (3-36) decreases release of norepinephrine via the Y2 receptor. Norepinephrine 32-46 neuropeptide Y Homo sapiens 0-3 30125310-6 2018 Plasma norepinephrine and epinephrine concentrations were significantly higher in patients with oral and oropharyngeal squamous cell carcinoma (SCC) compared to non-cancer patients. Norepinephrine 7-21 serpin family B member 3 Homo sapiens 144-147 18567701-0 2008 Phospholipase C-delta1 modulates sustained contraction of rat mesenteric small arteries in response to noradrenaline, but not endothelin-1. Norepinephrine 103-116 phospholipase C, delta 1 Rattus norvegicus 0-22 18567701-2 2008 Our aim was to investigate whether PLC-delta(1), a PLC isoform implicated in alpha(1)-adrenoreceptor signaling and the pathogenesis of hypertension, is involved in noradrenaline (NA) or endothelin (ET-1)-induced PIP(2) hydrolysis and contraction. Norepinephrine 164-177 phospholipase C, delta 1 Rattus norvegicus 35-47 30125310-7 2018 Oral SCC patients displayed plasma norepinephrine levels about six times higher than oropharyngeal SCC patients, and nine times higher than oral leukoplakia patients (p < .001). Norepinephrine 35-49 serpin family B member 3 Homo sapiens 5-8 18648551-8 2008 PC12 cell production of norepinephrine and dopamine was significantly blunted following exposure to recombinant rat C5a in a time-dependent and dose-dependent manner. Norepinephrine 24-38 complement C5 Rattus norvegicus 116-119 30125310-9 2018 Oropharyngeal SCC patients had higher plasma norepinephrine (p = .0382) and epinephrine levels (p = .045) than patients with oral leukoplakia. Norepinephrine 45-59 serpin family B member 3 Homo sapiens 14-17 30125310-10 2018 Multiple regression analyses showed that a history of high alcohol consumption was predictive for reduced plasma norepinephrine levels in the oral SCC group (p < .001). Norepinephrine 113-127 serpin family B member 3 Homo sapiens 147-150 30125310-11 2018 Anxiety symptom of "hand tremor" measured by the BAI was an independent predictor for higher plasma norepinephrine levels in HNSCC patients (beta = 157.5, p = .0377), while the "heart pounding/racing" symptom was independently associated with higher plasma epinephrine levels in the oropharyngeal SCC group (beta = 15.8, p = .0441). Norepinephrine 100-114 serpin family B member 3 Homo sapiens 127-130 29875227-5 2018 TAS-303 [4-piperidinyl 2,2-diphenyl-2-(propoxy-1,1,2,2,3,3,3-day7 )acetate hydrochloride] is a novel small-molecule selective norepinephrine reuptake inhibitor that displays significant norepinephrine transporter (NET) inhibitory activity toward the serotonin or dopamine transporters. Norepinephrine 126-140 solute carrier family 6 member 2 Rattus norvegicus 186-212 18397915-1 2008 In female rodents, hypothalamic norepinephrine (NE) has a role in stimulating the secretion of gonadotropin-releasing hormone (GnRH) that triggers the ovulatory surge of luteinizing hormone (LH). Norepinephrine 32-46 gonadotropin releasing hormone 1 Rattus norvegicus 95-125 18397915-1 2008 In female rodents, hypothalamic norepinephrine (NE) has a role in stimulating the secretion of gonadotropin-releasing hormone (GnRH) that triggers the ovulatory surge of luteinizing hormone (LH). Norepinephrine 32-46 gonadotropin releasing hormone 1 Rattus norvegicus 127-131 29875227-5 2018 TAS-303 [4-piperidinyl 2,2-diphenyl-2-(propoxy-1,1,2,2,3,3,3-day7 )acetate hydrochloride] is a novel small-molecule selective norepinephrine reuptake inhibitor that displays significant norepinephrine transporter (NET) inhibitory activity toward the serotonin or dopamine transporters. Norepinephrine 126-140 solute carrier family 6 member 2 Rattus norvegicus 214-217 20641420-2 2004 MAO-A preferentially oxidizes serotonin and noradrenaline, whereas MAO-B preferentially oxidizes phenethylamine. Norepinephrine 44-57 monoamine oxidase A Homo sapiens 0-5 30106035-6 2018 In essence, the literature reviewed herein supports our hypothesis of a tripartite neuroprotective role for noradrenaline in combating PD-related neuropathology and motor dysfunction via (1) inhibiting nigral microglial activation & pro-inflammatory mediator production, (2) promoting the synthesis of neurotrophic factors from midbrain astrocytes and (3) downregulating alpha-synuclein gene expression and protein abundance in a beta2-AR-dependent manner. Norepinephrine 108-121 synuclein alpha Homo sapiens 375-390 18177483-13 2008 We conclude that noradrenaline-induced increases in the expression of NHE-3, NBC-1, BSC-1 and aquaporin-2 are likely to play an important role in the regulation of salt and water transport by noradrenaline in the kidney and may explain, at least in part, the altered renal sodium and water handling associated with overactivation of the sympathetic system. Norepinephrine 192-205 aquaporin 2 Rattus norvegicus 94-105 29739827-9 2018 Finally, renal nerve dysfunction in Uchl1-/- mice is suggested given increased renal nerve arborization, decreased urinary norepinephrine, and impaired vascular reactivity. Norepinephrine 123-137 ubiquitin C-terminal hydrolase L1 Homo sapiens 36-41 18278799-7 2008 We also used immunocytochemistry to assess these areas for immunoreactive dopamine-beta-hydroxylase (DBH-ir), the enzyme that synthesizes norepinephrine. Norepinephrine 138-152 dopamine beta-hydroxylase Sturnus vulgaris 74-99 18278799-7 2008 We also used immunocytochemistry to assess these areas for immunoreactive dopamine-beta-hydroxylase (DBH-ir), the enzyme that synthesizes norepinephrine. Norepinephrine 138-152 dopamine beta-hydroxylase Sturnus vulgaris 101-104 29758252-8 2018 In contrast, selective noradrenaline reuptake inhibitor desipramine had a significant effect on RGS8tg in the FST. Norepinephrine 23-36 regulator of G-protein signaling 8 Mus musculus 96-100 18194185-5 2008 MAIN OUTCOME MEASURE: Both spontaneous myogenic activity and contractile responses to field stimulation, norepinephrine, histamine, and endothelin-1 were reduced by ClC blockers. Norepinephrine 105-119 cystic fibrosis transmembrane conductance regulator Oryctolagus cuniculus 165-168 18227761-1 2008 BACKGROUND: The monoamine oxidase-A (MAOA) gene plays a vital role in the metabolism of neurotransmitters, e.g, serotonin, norepinephrine, and dopamine. Norepinephrine 123-137 monoamine oxidase A Homo sapiens 16-35 18227761-1 2008 BACKGROUND: The monoamine oxidase-A (MAOA) gene plays a vital role in the metabolism of neurotransmitters, e.g, serotonin, norepinephrine, and dopamine. Norepinephrine 123-137 monoamine oxidase A Homo sapiens 37-41 19020660-11 2008 CONCLUSIONS: Our results show that the binding of apoB100-LDL to adipocytes via the LDL receptor inhibits intracellular noradrenaline-induced lipolysis in adipocytes. Norepinephrine 120-133 apolipoprotein B Mus musculus 50-57 18054863-6 2007 These data illustrate a mechanism of presynaptic modulation where the output of a large multiple-release-site synapse is potently regulated by endogenously released noradrenaline and suggests that the CeA may be a target for the central nociceptive actions of noradrenaline. Norepinephrine 165-178 pregnancy specific beta-1-glycoprotein 2 Homo sapiens 201-204 18054863-6 2007 These data illustrate a mechanism of presynaptic modulation where the output of a large multiple-release-site synapse is potently regulated by endogenously released noradrenaline and suggests that the CeA may be a target for the central nociceptive actions of noradrenaline. Norepinephrine 260-273 pregnancy specific beta-1-glycoprotein 2 Homo sapiens 201-204 17507294-13 2007 This observation may depend on altered coupling between electrical nerve activity and norepinephrine release and/or a changed norepinephrine uptake in RGS2-/- mice. Norepinephrine 126-140 regulator of G-protein signaling 2 Mus musculus 151-155 29355945-0 2018 Essential role of hippocampal noradrenaline in the regulation of spatial working memory and TDP-43 tissue pathology. Norepinephrine 30-43 TAR DNA binding protein Rattus norvegicus 92-98 17673674-1 2007 Alpha2-adrenoceptors are essential presynaptic regulators of norepinephrine release from sympathetic nerves. Norepinephrine 61-75 adrenergic receptor, alpha 2b Mus musculus 0-20 17200925-2 2007 The gene encoding dopamine beta-hydroxylase (DBH) could be one such factor since this hydroxylase converts dopamine to norepinephrine both of which are involved in cognition regulation. Norepinephrine 119-133 dopamine beta-hydroxylase Homo sapiens 18-43 17200925-2 2007 The gene encoding dopamine beta-hydroxylase (DBH) could be one such factor since this hydroxylase converts dopamine to norepinephrine both of which are involved in cognition regulation. Norepinephrine 119-133 dopamine beta-hydroxylase Homo sapiens 45-48 17448453-1 2007 OBJECTIVE: Phenylethanolamine-N-methyltransferase (PNMT), the enzyme that synthesizes epinephrine (EPI) from norepinephrine (NE) in the adrenal gland, is present in extra-adrenal tissues including heart. Norepinephrine 109-123 phenylethanolamine N-methyltransferase Oryctolagus cuniculus 51-55 29329391-0 2018 Oxidative burst and Dectin-1-triggered phagocytosis affected by norepinephrine and endocannabinoids: implications for fungal clearance under stress. Norepinephrine 64-78 C-type lectin domain containing 7A Homo sapiens 20-28 29456827-9 2018 Moreover, neurotransmitters including serotonin, norepinephrine, and dopamine were significantly increased in different brain regions of the Arhgef10 knockout mice. Norepinephrine 49-63 Rho guanine nucleotide exchange factor (GEF) 10 Mus musculus 141-149 30454587-5 2018 UCP1 is innately inhibited by cytosolic adenosine triphosphate (ATP) and is likely activated by fatty acids released from triglycerides within the cells; this lipolysis is stimulated by norepinephrine released from the sympathetic nerves innervating the tissue. Norepinephrine 186-200 uncoupling protein 1 Homo sapiens 0-4 28293733-1 2018 Type A monoamine oxidase (MAOA) catabolizes monoamine transmitters, serotonin, norepinephrine and dopamine, and plays a major role in the onset, progression and therapy of neuropsychiatric disorders. Norepinephrine 79-93 monoamine oxidase A Homo sapiens 7-24 28293733-1 2018 Type A monoamine oxidase (MAOA) catabolizes monoamine transmitters, serotonin, norepinephrine and dopamine, and plays a major role in the onset, progression and therapy of neuropsychiatric disorders. Norepinephrine 79-93 monoamine oxidase A Homo sapiens 26-30 29123236-4 2017 Leptin injection into the ventromedial hypothalamus (VMH) increased 2-deoxy-D-glucose (2DG) uptake in red-type skeletal muscle in wild-type (WT) mice accompanied with increased phosphorylation of the insulin receptor (IR) and Akt as well as of norepinephrine (NE) turnover in the muscle. Norepinephrine 244-258 leptin Mus musculus 0-6 28583436-9 2017 Stepwise regression analysis revealed that %FABP4 was highly correlated with that in norepinephrine. Norepinephrine 85-99 fatty acid binding protein 4 Homo sapiens 44-49 20144064-1 2007 The histamine H(3) receptor is involved in the central and peripheral regulation of levels of histamine and other neurotransmitters (e.g., acetylcholine, noradrenaline, dopamine, serotonin and GABA), which sets it up as a target in the treatment of various CNS (e.g., depression, schizophrenia, ADHD, dementia, neuropathic pain and sleep disorders), metabolic syndrome (e.g., obesity) and allergic disorders. Norepinephrine 154-167 histamine receptor H3 Homo sapiens 4-27 17394158-9 2007 Our results extend current knowledge about noradrenergic projections to specialized nuclei of the song control circuit and provide neuroanatomical evidence for the functional action of norepinephrine-modulating context-dependent ZENK expression in area X. Norepinephrine 185-199 early growth response protein 1 Taeniopygia guttata 229-233 17437549-1 2007 We recently reported a diurnal and norepinephrine (NE) -induced expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) in the rat pineal gland and postulated that this MKP-1 expression might impact adrenergic-regulated arylalkylamine-N-acetyltransferase (AA-NAT) activity via modulation of MAPKs. Norepinephrine 35-49 dual specificity phosphatase 1 Rattus norvegicus 133-138 17437549-1 2007 We recently reported a diurnal and norepinephrine (NE) -induced expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) in the rat pineal gland and postulated that this MKP-1 expression might impact adrenergic-regulated arylalkylamine-N-acetyltransferase (AA-NAT) activity via modulation of MAPKs. Norepinephrine 35-49 dual specificity phosphatase 1 Rattus norvegicus 189-194 17437549-1 2007 We recently reported a diurnal and norepinephrine (NE) -induced expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) in the rat pineal gland and postulated that this MKP-1 expression might impact adrenergic-regulated arylalkylamine-N-acetyltransferase (AA-NAT) activity via modulation of MAPKs. Norepinephrine 35-49 aralkylamine N-acetyltransferase Rattus norvegicus 240-274 17437549-1 2007 We recently reported a diurnal and norepinephrine (NE) -induced expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) in the rat pineal gland and postulated that this MKP-1 expression might impact adrenergic-regulated arylalkylamine-N-acetyltransferase (AA-NAT) activity via modulation of MAPKs. Norepinephrine 35-49 aralkylamine N-acetyltransferase Rattus norvegicus 276-282 17514581-3 2007 Furthermore, we observed that gene expression of GCH in the locus coeruleus (LC) in mice was enhanced by peripheral administration of LPS, resulting in increased concentrations of BH4, and norepinephrine, and its metabolite 4-hydroxy-3-methoxyphenylglycol (MHPG). Norepinephrine 189-203 GTP cyclohydrolase 1 Mus musculus 49-52 17514581-4 2007 These results suggest that tyrosine hydroxylase (TH) activity is increased by increased content of BH4 due to enhanced mRNA expression of GCH in the LC resulting in the increase in norepinephrine in the LC during endotoxemia. Norepinephrine 181-195 GTP cyclohydrolase 1 Mus musculus 138-141 17485013-1 2007 BACKGROUND: The aim of the present study was to evaluate the intervention of COX-1- and COX-2-derived prostaglandins in the responses of human gastroepiploic artery to sympathetic stimulation and norepinephrine. Norepinephrine 196-210 mitochondrially encoded cytochrome c oxidase I Homo sapiens 77-82 28583436-10 2017 CONCLUSIONS: Our study reveals the significant correlation between circulating FABP4 and norepinephrine levels during exercise testing. Norepinephrine 89-103 fatty acid binding protein 4 Homo sapiens 79-84 28804807-7 2017 RESULTS: CRH administration induced pronounced increases in cortisol and noradrenaline plasma concentrations, heart rate, and anxiety levels. Norepinephrine 73-86 corticotropin releasing hormone Homo sapiens 9-12 28598954-4 2017 METHOD: We used human renal proximal tubule cells to investigate the effects of noradrenaline on SGLT2 regulation. Norepinephrine 80-93 solute carrier family 5 member 2 Homo sapiens 97-102 28502584-6 2017 miR-325-3p blocked norepinephrine (NE) induced Aanat activation in cultured pinealocytes. Norepinephrine 19-33 aralkylamine N-acetyltransferase Rattus norvegicus 47-52 27979380-7 2017 Interestingly, NPY decreased brain serotonin and norepinephrine concentrations in fed chicks, but increased concentrations of brain dopamine and its metabolites in fasted and fed chicks, respectively. Norepinephrine 49-63 neuropeptide Y Homo sapiens 15-18 27979380-8 2017 Plasma epinephrine was decreased by NPY in fed chicks, but plasma concentrations of norepinephrine and epinephrine were increased significantly by NPY in fasted-heat exposed chicks. Norepinephrine 84-98 neuropeptide Y Homo sapiens 147-150 27753095-16 2017 Noradrenaline also evoked TRPC1 channel activity and associations between TRPC1, STIM1, Galphaq and PLCbeta1, which were inhibited by STIM1 knockdown. Norepinephrine 0-13 G protein subunit alpha q Homo sapiens 88-95 28352352-3 2017 Noradrenaline-induced lipolysis was enhanced by caffeine, which markedly increased the protein expression of adipose triglyceride lipase and hormone sensitive lipase. Norepinephrine 0-13 patatin-like phospholipase domain containing 2 Mus musculus 109-136 28352358-13 2017 In conclusion, the current study suggests that under conditions of stress, VEGF serves a role in the mechanism of action of DMI, through modulating activity of the norepinephrine system. Norepinephrine 164-178 vascular endothelial growth factor A Rattus norvegicus 75-79 28508370-5 2017 Tyrosine hydroxylase, dopamine beta hydroxylase are the key enzymes for the synthesis of norepinephrine; and neuropeptide Y (NPY) is the peptide that is co-stored and co-released with norepinephrine. Norepinephrine 89-103 dopamine beta-hydroxylase Homo sapiens 22-47 28508370-5 2017 Tyrosine hydroxylase, dopamine beta hydroxylase are the key enzymes for the synthesis of norepinephrine; and neuropeptide Y (NPY) is the peptide that is co-stored and co-released with norepinephrine. Norepinephrine 89-103 neuropeptide Y Homo sapiens 109-123 28508370-5 2017 Tyrosine hydroxylase, dopamine beta hydroxylase are the key enzymes for the synthesis of norepinephrine; and neuropeptide Y (NPY) is the peptide that is co-stored and co-released with norepinephrine. Norepinephrine 89-103 neuropeptide Y Homo sapiens 125-128 28508370-5 2017 Tyrosine hydroxylase, dopamine beta hydroxylase are the key enzymes for the synthesis of norepinephrine; and neuropeptide Y (NPY) is the peptide that is co-stored and co-released with norepinephrine. Norepinephrine 184-198 neuropeptide Y Homo sapiens 109-123 28508370-5 2017 Tyrosine hydroxylase, dopamine beta hydroxylase are the key enzymes for the synthesis of norepinephrine; and neuropeptide Y (NPY) is the peptide that is co-stored and co-released with norepinephrine. Norepinephrine 184-198 neuropeptide Y Homo sapiens 125-128 27825984-6 2017 Inhibition of PI3Kgamma lipid kinase activity by protein kinase A was disclosed as mechanism causing suppression of microglial migration by noradrenaline. Norepinephrine 140-153 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Homo sapiens 14-23 17439480-3 2007 We previously showed that the Mecp2-deficient mice, a mouse model of RS, have highly variable respiratory rhythm and frequent apneas due to reduced norepinephrine (NE) content, and a drastic decrease of tyrosine hydroxylase (TH)-expressing neurons in the medulla. Norepinephrine 148-162 methyl CpG binding protein 2 Mus musculus 30-35 27501468-8 2016 Western blot results showed that over-expression of miR-181a and miR-29b significantly repressed protein levels of NET, which is accompanied by a reduced [3 H] norepinephrine uptake, and glucocorticoid receptors in PC12 cells. Norepinephrine 160-174 solute carrier family 6 member 2 Rattus norvegicus 115-118 17328795-3 2007 Monoamine oxidase A (MAO-A) encodes an enzyme that degrades biogenic amines, including neurotransmitters such as norepinephrine, dopamine and serotonin. Norepinephrine 113-127 monoamine oxidase A Homo sapiens 0-19 27490896-6 2016 CTGF mRNA and protein levels were decreased in LV following RSD (p<0.01), accompanied by decreased expression of norepinephrine, renin, angiotensin II and aldosterone in plasma (p<0.05) compared with untreated MI rats. Norepinephrine 116-130 cellular communication network factor 2 Rattus norvegicus 0-4 17328795-3 2007 Monoamine oxidase A (MAO-A) encodes an enzyme that degrades biogenic amines, including neurotransmitters such as norepinephrine, dopamine and serotonin. Norepinephrine 113-127 monoamine oxidase A Homo sapiens 21-26 17082254-2 2007 Treatment of pinealocytes with norepinephrine (NE) caused an increase in the mRNA and protein levels of MKP-1 and AA-NAT, as well as in the AA-NAT activity and melatonin production. Norepinephrine 31-45 dual specificity phosphatase 1 Rattus norvegicus 104-109 17082254-2 2007 Treatment of pinealocytes with norepinephrine (NE) caused an increase in the mRNA and protein levels of MKP-1 and AA-NAT, as well as in the AA-NAT activity and melatonin production. Norepinephrine 31-45 aralkylamine N-acetyltransferase Rattus norvegicus 114-120 17082254-2 2007 Treatment of pinealocytes with norepinephrine (NE) caused an increase in the mRNA and protein levels of MKP-1 and AA-NAT, as well as in the AA-NAT activity and melatonin production. Norepinephrine 31-45 aralkylamine N-acetyltransferase Rattus norvegicus 140-146 26919286-2 2016 Catechol-O-methyl transferase (COMT) is a catecholamine-degrading enzyme, the substrates of which include dopamine, epinephrine, and norepinephrine. Norepinephrine 133-147 catechol-O-methyltransferase Rattus norvegicus 0-29 17012607-4 2007 Activation of UCP3 is indirectly regulated by norepinephrine (NE) and is dependent upon the availability of free fatty acids (FFAs). Norepinephrine 46-60 uncoupling protein 3 Rattus norvegicus 14-18 17103145-4 2006 The contractions to 5-HT were competitively antagonized by the 5-HT(2A) receptor antagonist ketanserin, whilst those to noradrenaline were antagonized by alpha(1)-(prazosin), alpha(2)-(rauwolscine and yohimbine) and alpha(2C/2B)-(OPC-28326) adrenoceptor antagonists. Norepinephrine 120-133 adrenoceptor alpha 1D Homo sapiens 154-162 26919286-2 2016 Catechol-O-methyl transferase (COMT) is a catecholamine-degrading enzyme, the substrates of which include dopamine, epinephrine, and norepinephrine. Norepinephrine 133-147 catechol-O-methyltransferase Rattus norvegicus 31-35 26776902-2 2016 In particular, converging lines of evidence have documented that these maladaptive manifestations of aggression are influenced by monoamine oxidase A (MAOA), the enzyme that catalyzes the degradation of brain serotonin, norepinephrine and dopamine. Norepinephrine 220-234 monoamine oxidase A Homo sapiens 130-149 26776902-2 2016 In particular, converging lines of evidence have documented that these maladaptive manifestations of aggression are influenced by monoamine oxidase A (MAOA), the enzyme that catalyzes the degradation of brain serotonin, norepinephrine and dopamine. Norepinephrine 220-234 monoamine oxidase A Homo sapiens 151-155 27148966-1 2016 Dopamine beta-hydroxylase (DBH) converts dopamine (DA) to norepinephrine (NE) in noradrenergic/adrenergic cells. Norepinephrine 58-72 dopamine beta-hydroxylase Homo sapiens 0-25 27148966-1 2016 Dopamine beta-hydroxylase (DBH) converts dopamine (DA) to norepinephrine (NE) in noradrenergic/adrenergic cells. Norepinephrine 58-72 dopamine beta-hydroxylase Homo sapiens 27-30 27124282-7 2016 RESULTS: At baseline, serum FABP4 level was correlated with adiposity, renal dysfunction and noradrenaline level. Norepinephrine 93-106 fatty acid binding protein 4 Homo sapiens 28-33 27124282-9 2016 Change in FABP4 level was positively correlated with change in levels of fasting glucose (r = 0.329, P = 0.044), HbA1c (r = 0.329, P = 0.044) and noradrenaline (r = 0.329, P = 0.041) but was not significantly correlated with change in adiposity or other variables. Norepinephrine 146-159 fatty acid binding protein 4 Homo sapiens 10-15 27152332-3 2016 We report the crystal structure of human dopamine beta-hydroxylase, which is the enzyme converting dopamine to norepinephrine. Norepinephrine 111-125 dopamine beta-hydroxylase Homo sapiens 41-66 26843180-3 2016 In fact, previous studies have suggested that norepinephrine can functionally interact with D4R. Norepinephrine 46-60 dopamine receptor D4 Homo sapiens 92-95 26843180-5 2016 By using radioligand binding and bioluminescent resonance energy transfer (BRET) assays in transfected cells, the present study attempted a careful comparison between dopamine and norepinephrine in their possible activation of all D2-like receptors, including the two D2R isoforms and the most common D4R polymorphic variants. Norepinephrine 180-194 dopamine receptor D4 Homo sapiens 301-304 16876143-1 2006 BACKGROUND: Dopamine beta hydroxylase (DbetaH) catalyzes the conversion of dopamine to noradrenaline. Norepinephrine 87-100 dopamine beta-hydroxylase Homo sapiens 12-37 26843180-7 2016 Norepinephrine acted as a potent agonist for all D2-like receptor subtypes, with the general rank order of potency of D3R > D4R >= D2SR >= D2L. Norepinephrine 0-14 dopamine receptor D4 Homo sapiens 127-130 26843180-9 2016 The most striking differences were observed with Galphai2, where the rank order of potencies for both dopamine and norepinephrine were D4R > D2SR = D2LR >> D3R. Norepinephrine 115-129 dopamine receptor D4 Homo sapiens 135-138 26663782-0 2016 Norepinephrine Controls Effector T Cell Differentiation through beta2-Adrenergic Receptor-Mediated Inhibition of NF-kappaB and AP-1 in Dendritic Cells. Norepinephrine 0-14 adrenergic receptor, beta 2 Mus musculus 64-89 17014691-4 2006 Here we analyzed the effect of tumor necrosis factor-alpha (TNF-alpha) and corticosterone on the transcription of the Aa-nat, hiomt and 14-3-3 protein genes in denervated pineal glands of rats stimulated for 5 hr with norepinephrine, using real-time reverse transcription-polymerase chain reaction. Norepinephrine 218-232 aralkylamine N-acetyltransferase Rattus norvegicus 118-142 17014691-8 2006 In addition, corticosterone induced a potentiation of norepinephrine-induced Aa-nat transcription even after 48 hr of incubation. Norepinephrine 54-68 aralkylamine N-acetyltransferase Rattus norvegicus 77-83 26556532-2 2016 Noradrenaline (NA) is one of the main modulators of GnRH release, and NA fibers are found in close apposition to kisspeptin neurons in the RP3V. Norepinephrine 0-13 gonadotropin releasing hormone 1 Rattus norvegicus 52-56 26025460-0 2016 Erythropoietin Reverses Sepsis-Induced Vasoplegia to Norepinephrine Through Preservation of alpha1D-Adrenoceptor mRNA Expression and Inhibition of GRK2-Mediated Desensitization in Mouse Aorta. Norepinephrine 53-67 erythropoietin Mus musculus 0-14 26677330-11 2015 CONCLUSION: These results demonstrate that serum levels of interleukin-6, interleukin-8, and macrophage inflammatory protein-1beta as potential blood biomarkers could be utilized to identify the responsiveness of patients to serotonin and norepinephrine reuptake inhibitor like milnacipran, or to identify those patients who may experience AEs strong enough to warrant discontinuation of treatment. Norepinephrine 239-253 C-C motif chemokine ligand 4 like 2 Homo sapiens 93-130 26403854-10 2015 In multiple regression analysis, renalase was predicted by plasma dopamine and norepinephrine as also diastolic office blood pressure and left ventricle ejection fraction. Norepinephrine 79-93 renalase, FAD dependent amine oxidase Homo sapiens 33-41 26492961-6 2015 This new molecule, by combining two distinct mechanisms of action, mu-opioid receptor agonism (MOR) and noradrenaline reuptake inhibition (NRI), introduces a new pharmacological class called MOR-NRI. Norepinephrine 104-117 opioid receptor mu 1 Homo sapiens 191-194 26362189-8 2015 Taken together, our data suggest that curcumin can potentially prevent obesity by inducing browning of inguinal WAT via the norepinephrine-beta3AR pathway. Norepinephrine 124-138 adrenergic receptor, beta 3 Mus musculus 139-146 26111885-3 2015 In obese mice, lentivirus mediated-FNDC5 overexpression enhanced energy expenditure, lipolysis and insulin sensitivity, and reduced hyperlipidemia, hyperglycemia, hyperinsulinism, blood pressure and norepinephrine levels; it increased hormone-sensitive lipase (HSL) expression and phosphorylation, and reduced perilipin level and adipocyte diameter in adipose tissues. Norepinephrine 199-213 fibronectin type III domain containing 5 Mus musculus 35-40 26049174-10 2015 Mesenteric arteries from high-fat-BK beta1-knockout mice had higher norepinephrine reactivity, greater wall thickness and collagen accumulation than high-fat-wild-type mesenteric arteries. Norepinephrine 68-82 hemoglobin, beta adult major chain Mus musculus 37-42 25869507-7 2015 The combined treatment reversed the hyporeactivity to nor-adrenaline through preservation of alpha1D AR mRNA/protein expression and reversal of alpha1D AR desensitization mediated by GRK2/Gbetagamma pathway. Norepinephrine 54-68 G protein-coupled receptor kinase 2 Mus musculus 183-187 25935138-7 2015 Additionally, overexpression of HSP70 via transfection with the pEGFP-rHSP70 plasmid attenuated norepinephrine (NE)-induced apoptosis. Norepinephrine 96-110 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 32-37 25956992-0 2015 Stabilization of Alpha-Synuclein Oligomers In Vitro by the Neurotransmitters, Dopamine and Norepinephrine: The Effect of Oxidized Catecholamines. Norepinephrine 91-105 synuclein alpha Homo sapiens 17-32 25956992-2 2015 The neurotransmitters dopamine and norepinephrine have been shown to both inhibit the formation of these fibrils and disaggregate existing fibrils, yielding the more toxic oligomeric form of alpha-synuclein. Norepinephrine 35-49 synuclein alpha Homo sapiens 191-206 25818584-9 2015 Norepinephrine also decreased mRNA expression of osterix, collagen I, and osteocalcin by mesenchymal stem cells at 7 and 14 d of stimulation and increased the expression of RANKL and RANKL/OPG ratio by mesenchymal stem cells at 2 h. In conclusion, CIS and UAC synergistically promote condylar subchondral bone loss and cartilage degradation; such processes are partially regulated by norepinephrine within subchondral bone. Norepinephrine 0-14 bone gamma-carboxyglutamate protein 2 Mus musculus 74-85 17027833-3 2006 This study examines the associations of beta2-adrenoceptor polymorphism with relationships between plasma norepinephrine (NE) and leptin to evaluate further the mechanisms of obesity. Norepinephrine 106-120 leptin Homo sapiens 130-136 16770335-2 2006 Monoamine oxidase A deaminates the monoamine neurotransmitters serotonin, dopamine (DA), and noradrenaline. Norepinephrine 93-106 monoamine oxidase A Homo sapiens 0-19 25818584-9 2015 Norepinephrine also decreased mRNA expression of osterix, collagen I, and osteocalcin by mesenchymal stem cells at 7 and 14 d of stimulation and increased the expression of RANKL and RANKL/OPG ratio by mesenchymal stem cells at 2 h. In conclusion, CIS and UAC synergistically promote condylar subchondral bone loss and cartilage degradation; such processes are partially regulated by norepinephrine within subchondral bone. Norepinephrine 0-14 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 173-178 16893419-2 2006 Interestingly, in GATA-3-/- mice, noradrenaline (NA) deficiency is a proximal cause of embryonic lethality. Norepinephrine 34-47 GATA binding protein 3 Mus musculus 18-24 25818584-9 2015 Norepinephrine also decreased mRNA expression of osterix, collagen I, and osteocalcin by mesenchymal stem cells at 7 and 14 d of stimulation and increased the expression of RANKL and RANKL/OPG ratio by mesenchymal stem cells at 2 h. In conclusion, CIS and UAC synergistically promote condylar subchondral bone loss and cartilage degradation; such processes are partially regulated by norepinephrine within subchondral bone. Norepinephrine 0-14 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 183-188 25336319-3 2015 Moreover, DBH, whose activity and levels are strongly controlled by the DBH gene, is a key enzyme in the conversion of dopamine (DA) to norepinephrine (NE) associated with excited behavior. Norepinephrine 136-150 dopamine beta-hydroxylase Homo sapiens 10-13 25336319-3 2015 Moreover, DBH, whose activity and levels are strongly controlled by the DBH gene, is a key enzyme in the conversion of dopamine (DA) to norepinephrine (NE) associated with excited behavior. Norepinephrine 136-150 dopamine beta-hydroxylase Homo sapiens 72-75 25903953-7 2015 The association with noradrenaline remained significant also when adjusted for LVEF and plasma BNP, suggesting a significant contribution of adrenals to the circulating pool of catecholamines in subjects with systolic HF. Norepinephrine 21-34 natriuretic peptides B Sus scrofa 95-98 25793511-10 2015 Central GLP-1R activation also increased NTS expression of dopamine-beta-hydroxylase, a key enzyme in noradrenaline synthesis, indicating a biological link between these two systems. Norepinephrine 102-115 dopamine beta-hydroxylase Rattus norvegicus 59-84 25789868-11 2015 RESULTS: Adrenaline and noradrenaline correlated positively with syndecan-1 and thrombomodulin i.e., biomarkers reflecting endothelial damage (both p<0.05). Norepinephrine 24-37 thrombomodulin Homo sapiens 80-94 24888991-2 2015 Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine in central neurons and thus is critically involved in maintaining the transformational homeostasis. Norepinephrine 72-86 dopamine beta-hydroxylase Homo sapiens 0-25 24888991-2 2015 Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine in central neurons and thus is critically involved in maintaining the transformational homeostasis. Norepinephrine 72-86 dopamine beta-hydroxylase Homo sapiens 27-30 26158633-5 2015 Moreover, CRY1 mRNA expression was inversely correlated with the plasma level of noradrenaline (r = -0.36, p < 0.05), while PER3, CRY2, and BMAL1 mRNA expression directly correlated with the plasma level of noradrenaline (r = 0.55, r = 0.66, and r = 0.57, respectively; p < 0.001). Norepinephrine 81-94 cryptochrome circadian regulator 1 Homo sapiens 10-14 26732055-4 2015 The main action of G-CSF - G-CSFR linkage is stimulation of the production, mobilization, survival and chemotaxis of neutrophils, but there are many other G-CSF effects: growth and migration of endothelial cells, decrease of norepinephrine reuptake, increase in osteoclastic activity and decrease in osteoblast activity. Norepinephrine 225-239 colony stimulating factor 3 Homo sapiens 19-24 26732055-4 2015 The main action of G-CSF - G-CSFR linkage is stimulation of the production, mobilization, survival and chemotaxis of neutrophils, but there are many other G-CSF effects: growth and migration of endothelial cells, decrease of norepinephrine reuptake, increase in osteoclastic activity and decrease in osteoblast activity. Norepinephrine 225-239 colony stimulating factor 3 Homo sapiens 27-33 26732055-4 2015 The main action of G-CSF - G-CSFR linkage is stimulation of the production, mobilization, survival and chemotaxis of neutrophils, but there are many other G-CSF effects: growth and migration of endothelial cells, decrease of norepinephrine reuptake, increase in osteoclastic activity and decrease in osteoblast activity. Norepinephrine 225-239 colony stimulating factor 3 Homo sapiens 27-32 25515516-5 2015 P2X1 receptors expressed in blood vessels can be activated by ATP coreleased with noradrenaline as a sympathetic neurotransmitter, leading to smooth muscle depolarisation and contraction. Norepinephrine 82-95 purinergic receptor P2X 1 Homo sapiens 0-4 25478705-2 2015 In vitro, norepinephrine and epinephrine inhibit placental 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), which protects the fetus from F overexposure by inactivating it to cortisone (E). Norepinephrine 10-24 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 59-114 25975715-10 2015 Reduced DBH expression would be consistent with decreased conversion of dopamine to noradrenaline and thus with a relative hypo-noradrenergic state in ADHD. Norepinephrine 84-97 dopamine beta-hydroxylase Homo sapiens 8-11 16712929-4 2006 Balb/c mice treated (i.p., twice, 16 h apart) with MPTP (30 mg/kg) or PRP-1 (1.6 mg/kg), but not PRP-4 (1.6 mg/kg) showed significant loss of striatal dopamine and norepinephrine as assayed by an HPLC-electrochemical procedure. Norepinephrine 164-178 placental prolactin-related protein 1 Bos taurus 70-75 16829576-1 2006 Monoamine oxidase A (MAO A) degrades serotonin, norepinephrine, and dopamine and produces reactive oxygen that may cause neuronal cell death. Norepinephrine 48-62 monoamine oxidase A Homo sapiens 0-19 16829576-1 2006 Monoamine oxidase A (MAO A) degrades serotonin, norepinephrine, and dopamine and produces reactive oxygen that may cause neuronal cell death. Norepinephrine 48-62 monoamine oxidase A Homo sapiens 21-26 16252068-1 2006 As the enzyme dopamine-beta-hydroxylase (DbetaH) converts dopamine to norepinephrine and both transmitters seem to be involved in the pathology of alcoholism and severe alcohol withdrawal symptoms, the gene encoding DbetaH (DBH) was applied to explore the genetic background of alcoholism and severe withdrawal symptoms. Norepinephrine 70-84 dopamine beta-hydroxylase Homo sapiens 14-39 24986918-1 2014 Dopamine beta-hydroxylase (DBH) is the biosynthetic enzyme catalyzing formation of norepinephrine. Norepinephrine 83-97 dopamine beta-hydroxylase Homo sapiens 0-25 16805813-0 2006 Cannabinoids attenuate norepinephrine-induced melatonin biosynthesis in the rat pineal gland by reducing arylalkylamine N-acetyltransferase activity without involvement of cannabinoid receptors. Norepinephrine 23-37 aralkylamine N-acetyltransferase Rattus norvegicus 105-139 16805813-4 2006 We demonstrated that treatment of cultured rat pineals with 9-carboxy-11-nor-delta-9-tetrahydrocannabinol (THC), cannabidiol or cannabinol significantly reduced norepinephrine-induced arylalkylamine N-acetyltransferase (AANAT) activity and melatonin biosynthesis. Norepinephrine 161-175 aralkylamine N-acetyltransferase Rattus norvegicus 184-218 16805813-4 2006 We demonstrated that treatment of cultured rat pineals with 9-carboxy-11-nor-delta-9-tetrahydrocannabinol (THC), cannabidiol or cannabinol significantly reduced norepinephrine-induced arylalkylamine N-acetyltransferase (AANAT) activity and melatonin biosynthesis. Norepinephrine 161-175 aralkylamine N-acetyltransferase Rattus norvegicus 220-225 24986918-1 2014 Dopamine beta-hydroxylase (DBH) is the biosynthetic enzyme catalyzing formation of norepinephrine. Norepinephrine 83-97 dopamine beta-hydroxylase Homo sapiens 27-30 25179535-6 2014 Furthermore, the expression of the Notch ligand Jagged 1 was significantly upregulated by norepinephrine at both mRNA and protein levels in breast cancer cells. Norepinephrine 90-104 jagged canonical Notch ligand 1 Homo sapiens 48-56 25179535-7 2014 Inhibitors of beta2-adrenergic receptor (beta2-AR), protein kinase A (PKA), and mTOR could reverse norepinephrine-induced Jagged 1 upregulation, indicating that the beta2-AR-PKA-mTOR pathway participates in this process. Norepinephrine 99-113 jagged canonical Notch ligand 1 Homo sapiens 122-130 25179535-8 2014 Knockdown of Jagged 1 expression in breast cancer cells not only repressed norepinephrine-induced activation of the Notch pathway in cocultured endothelial cells but also evidently impaired the effects of norepinephrine on capillary-like sprout formation. Norepinephrine 75-89 jagged canonical Notch ligand 1 Homo sapiens 13-21 25179535-8 2014 Knockdown of Jagged 1 expression in breast cancer cells not only repressed norepinephrine-induced activation of the Notch pathway in cocultured endothelial cells but also evidently impaired the effects of norepinephrine on capillary-like sprout formation. Norepinephrine 205-219 jagged canonical Notch ligand 1 Homo sapiens 13-21 25179535-9 2014 These data demonstrate that tumor angiogenesis mediated by the Jagged 1/Notch intercellular signaling is governed by the norepinephrine-activated beta2-AR-PKA-mTOR pathway. Norepinephrine 121-135 jagged canonical Notch ligand 1 Homo sapiens 63-71 25050919-7 2014 Importantly, pro-hypertrophic signalling pathways such as those driven by angiotensin II and norepinephrine also regulate miR-23a-miR-27a-miR-24-2 cluster proximal promoter activity. Norepinephrine 93-107 microRNA 24-2 Homo sapiens 138-146 24657329-7 2014 All of the nine antidepressant compounds showed moderate inhibitory effects on OCT2-mediated metformin, serotonin and/or norepinephrine uptake. Norepinephrine 121-135 solute carrier family 22 member 2 Homo sapiens 79-83 24912137-8 2014 Results show that the adenosine A2a receptor agonist, CGS 21680, increases neurotransmitter release, in particular, glutamate and noradrenaline and such response is mediated by protein kinase A activation, which in turn increased synapsin I phosphorylation. Norepinephrine 130-143 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 177-193 24799612-8 2014 Because the 2 protein kinases, STE20p-related proline- and alanine-rich kinase (encoded by STK39) and oxidative stress-response kinase 1, phosphorylate and activate NCC, we examined their roles in norepinephrine effects. Norepinephrine 197-211 serine/threonine kinase 39 Mus musculus 91-96 24952646-8 2014 Under conditions of chronic variable stress in mice, sympathetic nerve fibers released surplus noradrenaline, which signaled bone marrow niche cells to decrease CXCL12 levels through the beta3-adrenergic receptor. Norepinephrine 95-108 adrenergic receptor, beta 3 Mus musculus 187-212 24904340-7 2014 Glutamate, serotonin, noradrenaline, and histamine are activated by stress and exert an inhibitory effect on serotonin outflow, in part by "flooding" 5-HT1A autoreceptors by serotonin itself. Norepinephrine 22-35 5-hydroxytryptamine receptor 1A Homo sapiens 150-156 16510159-6 2006 In particular, central catecholamine depletion, dexmedetomidine-induced inhibition of noradrenaline release and blockade of alpha(1)-adrenoceptors with prazosin, up-regulated CYP1A2 expression. Norepinephrine 86-99 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 175-181 24510409-1 2014 Monoamine oxidase A (MAOA) catalyzes monoamine neurotransmitters including dopamine, 5-hydroxytryptamine (5-HT, serotonin), and norepinephrine. Norepinephrine 128-142 monoamine oxidase A Homo sapiens 0-19 24333843-5 2014 Given its opiate-sensitivity and its well-characterized molecular and cellular adaptations to morphine exposure, we investigated the anatomical distribution of WLS and MOR in the rat locus coeruleus (LC)-norepinephrine (NE) system. Norepinephrine 204-218 Wnt ligand secretion mediator Rattus norvegicus 160-163 24252179-2 2014 Based on our previous study showing that overexpression of wild-type or mutant alpha-synuclein (alpha-SYN) interferes with cAMP/PKA-dependent transcriptional activation in norepinephrine (NE)-producing cells, the effect of wild-type and mutant alpha-SYN on cAMP response element (CRE)-mediated regulation of the NE-synthesizing enzyme dopamine beta-hydroxylase (DBH) was evaluated in this study. Norepinephrine 172-186 synuclein, alpha Mus musculus 79-94 16442134-6 2006 Interestingly, sex-specific alterations in neurochemical levels were detected, including elevated noradrenaline and reduced glutamate levels in striatum of Wa-1 males, increased noradrenaline and reduced serotonin metabolite levels in hippocampus of Wa-1 females, reduced serotonin metabolite levels in cortex and amygdala of Wa-1 females, and reduced noradrenaline, dopamine, serotonin, glutamate and glycine levels in hypothalamus of Wa-1 females compared to their respective controls. Norepinephrine 98-111 transforming growth factor alpha Mus musculus 156-160 16154248-3 2006 In addition, all three proteins are required for l-norepinephrine-facilitated iron uptake from transferrin as judged by failure of a fepA iroN cir triple mutant to grow in serum-containing medium in the presence of l-norepinephrine. Norepinephrine 49-65 circling Mus musculus 143-146 24252179-2 2014 Based on our previous study showing that overexpression of wild-type or mutant alpha-synuclein (alpha-SYN) interferes with cAMP/PKA-dependent transcriptional activation in norepinephrine (NE)-producing cells, the effect of wild-type and mutant alpha-SYN on cAMP response element (CRE)-mediated regulation of the NE-synthesizing enzyme dopamine beta-hydroxylase (DBH) was evaluated in this study. Norepinephrine 172-186 synuclein, alpha Mus musculus 96-105 24757681-1 2014 Neuropeptide Y was isolated from the porcine brain in 1982 and shown to be colocalized with noradrenaline in sympathetic nerve terminals. Norepinephrine 92-105 neuropeptide Y Homo sapiens 0-14 24297249-1 2014 We found previously that stimulation of natriuretic peptide receptor (NPR)-B by C-type natriuretic peptide (CNP) in failing rat ventricle potentiates beta1-adrenoceptor (beta1-AR)-mediated inotropic response to noradrenaline through cGMP-mediated inhibition of phosphodiesterase (PDE) 3, thereby enhancing cAMP-mediated signalling. Norepinephrine 211-224 natriuretic peptide receptor 2 Rattus norvegicus 70-76 24297249-9 2014 We identified several small molecule NPR-B antagonists by high throughput screening and show in a functional heart preparation that blocking NPR-B stimulation with a small molecule compound can reduce the potentiating effect of CNP on the beta1-AR-mediated inotropic response to noradrenaline. Norepinephrine 279-292 natriuretic peptide receptor 2 Rattus norvegicus 141-146 23906995-1 2013 OBJECTIVE: Dopamine-beta-hydroxylase (DBH) metabolizes the conversion of dopamine to noradrenaline. Norepinephrine 85-98 dopamine beta-hydroxylase Homo sapiens 11-36 23906995-1 2013 OBJECTIVE: Dopamine-beta-hydroxylase (DBH) metabolizes the conversion of dopamine to noradrenaline. Norepinephrine 85-98 dopamine beta-hydroxylase Homo sapiens 38-41 23962674-4 2013 In a sample of 100 healthy adults, we studied the dependency of an individual"s size of PES on the DBH5"-ins/del polymorphism-a variation in the DBH gene associated with the production of the enzyme dopamine beta-hydroxylase, which catalyzes the conversion of dopamine to norepinephrine. Norepinephrine 272-286 dopamine beta-hydroxylase Homo sapiens 199-224 16269576-8 2006 Urinary norepinephrine and epinephrine excretion was higher in RGS2(-/-) than in RGS2(+/+) mice. Norepinephrine 8-22 regulator of G-protein signaling 2 Mus musculus 63-67 16505658-1 2006 OBJECTIVES: To evaluate the potential differential effects of norepinephrine, an alpha1-, beta1-, and beta2-receptor agonist, to the alpha1-agonist phenylephrine on jejunal mucosal perfusion, gastric-arterial PCO2 gradient, and the global splanchnic oxygen demand-supply relationship after cardiac surgery. Norepinephrine 62-76 adrenoceptor alpha 1D Homo sapiens 133-139 24058067-1 2013 Emotionally enhanced memory and susceptibility to intrusive memories after trauma have been linked to a deletion variant (i.e., a form of a gene in which certain amino acids are missing) of ADRA2B, the gene encoding subtype B of the alpha2-adrenergic receptor, which influences norepinephrine activity. Norepinephrine 278-292 adrenoceptor alpha 2B Homo sapiens 190-196 24005671-0 2013 Extracellular norepinephrine clearance by the norepinephrine transporter is required for skeletal homeostasis. Norepinephrine 14-28 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 46-72 23858446-2 2013 The combined deficiency of MAO A and B results in significantly elevated levels of serotonin (5-hydroxytryptamine), norepinephrine, dopamine, and beta-phenylethylamine; in humans and mice, these neurochemical changes are accompanied by neurodevelopmental perturbations as well as autistic-like responses. Norepinephrine 116-130 monoamine oxidase A Homo sapiens 27-38 23845478-1 2013 Norepinephrine (NE) is detected amperometrically using the enzyme Phenylethanolamine N-methyl transferase and cofactor S-(5"-Adenosyl)-l-methionine chloride dihydrochloride with disposable screen printed mesoporous carbon electrodes. Norepinephrine 0-14 phenylethanolamine N-methyltransferase Oryctolagus cuniculus 66-105 23604714-4 2013 The perfusion pressure increases in isolated perfused mesenteric vascular beds in response to norepinephrine were also enhanced in CPI-17-Tg mice. Norepinephrine 94-108 protein phosphatase 1, regulatory inhibitor subunit 14A Mus musculus 131-137 23707643-1 2013 Many genes associated with dopamine (DA) and norepinephrine (NE) systems influence cognitive deficits of schizophrenia patients, but one key enzyme is dopamine beta-hydroxylase (DBH), which converts DA to NE and whose activity and levels are under strong genetic control. Norepinephrine 45-59 dopamine beta-hydroxylase Homo sapiens 151-176 23707643-1 2013 Many genes associated with dopamine (DA) and norepinephrine (NE) systems influence cognitive deficits of schizophrenia patients, but one key enzyme is dopamine beta-hydroxylase (DBH), which converts DA to NE and whose activity and levels are under strong genetic control. Norepinephrine 45-59 dopamine beta-hydroxylase Homo sapiens 178-181 16364652-1 2006 The histamine H3 receptor subtype negatively modulates the release of various neurotransmitters such as histamine, glutamate, norepinephrine, acetylcholine and many others mainly in the CNS and H3 antagonists have been developed to treat central diseases characterized by neurotransmission disturbance such as schizophrenia, memory/learning and sleep disorders. Norepinephrine 126-140 histamine receptor H3 Homo sapiens 4-25 23389997-7 2013 Furthermore, treatment with desipramine, an antidepressant with specific inhibitory effects on norepinephrine transport, prevented an increased dopamine beta-hydroxylase expression by chronic social defeat in the locus coeruleus and its main terminal regions such as the hippocampus, frontal cortex and amygdala. Norepinephrine 95-109 dopamine beta-hydroxylase Rattus norvegicus 144-169 16423344-0 2006 [35S]GTPgammaS binding at the human dopamine D4 receptor variants hD4.2, hD4.4 and hD4.7 following stimulation by dopamine, epinephrine and norepinephrine. Norepinephrine 140-154 dopamine receptor D4 Homo sapiens 36-56 23389997-9 2013 The present findings indicate that chronic social defeat activates the locus coeruleus-norepinephrine system by upregulating the expression of dopamine beta-hydroxylase, which may increase norepinephrine synthesis. Norepinephrine 87-101 dopamine beta-hydroxylase Rattus norvegicus 143-168 16423344-8 2006 Agonism of norepinephrine and epinephrine at the dopamine D4 receptor may indicate an important way of cross-reactivity among the different monoamine neurotransmitter systems. Norepinephrine 11-25 dopamine receptor D4 Homo sapiens 49-69 16412264-6 2006 However, relative to the normal saline group, in the norepinephrine-treated hearts, heart function, and myocardial ultrastructure deteriorated significantly, apoptosis and amount of Bax product increased significantly, and the ATP, phosphocreatine, and glycogen content decreased significantly, as did the amount of Bcl-2 product. Norepinephrine 53-67 BCL2 associated X, apoptosis regulator Rattus norvegicus 182-185 23389997-9 2013 The present findings indicate that chronic social defeat activates the locus coeruleus-norepinephrine system by upregulating the expression of dopamine beta-hydroxylase, which may increase norepinephrine synthesis. Norepinephrine 189-203 dopamine beta-hydroxylase Rattus norvegicus 143-168 16380518-1 2006 An impairment of cardiac norepinephrine reuptake through the neuronal norepinephrine transporter promotes depletion of cardiac norepinephrine stores and local cardiac sympathetic activation in heart failure. Norepinephrine 25-39 solute carrier family 6 member 2 Rattus norvegicus 70-96 23384717-1 2013 OBJECTIVES: Dopamine-beta-hydroxylase (DBH) is the enzyme responsible for the conversion of dopamine (DA) to norepinephrine (NE, noradrenaline) which is a key neurotransmitter in the central and peripheral nervous systems. Norepinephrine 109-123 dopamine beta-hydroxylase Homo sapiens 12-37 16474208-3 2006 We investigated the role of JNK in the contractile response to norepinephrine (NE) in rat aortic smooth muscle. Norepinephrine 63-77 mitogen-activated protein kinase 8 Rattus norvegicus 28-31 16099857-2 2005 Addition of c-lact or MG132 3 h after norepinephrine (NE) stimulation produced a significant increase in AA-NAT protein level and enzyme activity. Norepinephrine 38-52 aralkylamine N-acetyltransferase Rattus norvegicus 105-111 16051698-6 2005 Isoprenaline, noradrenaline, and adrenaline (-log EC(50) = 5.9, 5.5, and 5.7, respectively) stimulated an association between the beta(2)-adrenoceptor and beta-arrestin 2 at much higher concentrations than required for activation of cAMP accumulation (-log EC(50) = 7.6, 6.3, and 7.7, respectively). Norepinephrine 14-27 adrenergic receptor, beta 2 Mus musculus 130-150 16051698-6 2005 Isoprenaline, noradrenaline, and adrenaline (-log EC(50) = 5.9, 5.5, and 5.7, respectively) stimulated an association between the beta(2)-adrenoceptor and beta-arrestin 2 at much higher concentrations than required for activation of cAMP accumulation (-log EC(50) = 7.6, 6.3, and 7.7, respectively). Norepinephrine 14-27 arrestin, beta 2 Mus musculus 155-170 16358768-2 2005 Administration of alpha-methyl-para-tyrosine led to decreased levels of dopamine and noradrenaline in the areas of migration of GnRH-neurons in fetuses on days 17 and 21 of prenatal development. Norepinephrine 85-98 gonadotropin releasing hormone 1 Rattus norvegicus 128-132 23384717-1 2013 OBJECTIVES: Dopamine-beta-hydroxylase (DBH) is the enzyme responsible for the conversion of dopamine (DA) to norepinephrine (NE, noradrenaline) which is a key neurotransmitter in the central and peripheral nervous systems. Norepinephrine 109-123 dopamine beta-hydroxylase Homo sapiens 39-42 23384717-1 2013 OBJECTIVES: Dopamine-beta-hydroxylase (DBH) is the enzyme responsible for the conversion of dopamine (DA) to norepinephrine (NE, noradrenaline) which is a key neurotransmitter in the central and peripheral nervous systems. Norepinephrine 129-142 dopamine beta-hydroxylase Homo sapiens 12-37 16226229-1 2005 In vitro experiments show norepinephrine activates glycogen phosphorylase and glycogenolysis in forebrain glia. Norepinephrine 26-40 glycogen phosphorylase L Rattus norvegicus 51-73 23384717-1 2013 OBJECTIVES: Dopamine-beta-hydroxylase (DBH) is the enzyme responsible for the conversion of dopamine (DA) to norepinephrine (NE, noradrenaline) which is a key neurotransmitter in the central and peripheral nervous systems. Norepinephrine 129-142 dopamine beta-hydroxylase Homo sapiens 39-42 23450051-10 2013 Although baseline PCSK9 concentrations were not associated to severity scores, PCSK9 values at day 8 were related to injury severity score (beta = 6.17; P = .0007), length of stay in ICU (beta = 6.14; P = .0001), and duration of both mechanical ventilation (beta = 8.26; P = .0001) and norepinephrine infusion (beta = 18.57; P = .015). Norepinephrine 286-300 proprotein convertase subtilisin/kexin type 9 Homo sapiens 79-84 16127244-4 2005 Depletion of central noradrenaline by 6-hydroxydopamine abolished the depressant effect of tizanidine on the MSR almost completely and attenuated the effect on the DSR. Norepinephrine 21-34 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Rattus norvegicus 109-112 16210796-1 2005 Dopamine and noradrenaline are catecholamine neurotransmitters that are produced by biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine beta -hydroxylase (DBH). Norepinephrine 13-26 tyrosine hydroxylase Canis lupus familiaris 113-133 16210796-1 2005 Dopamine and noradrenaline are catecholamine neurotransmitters that are produced by biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine beta -hydroxylase (DBH). Norepinephrine 13-26 tyrosine hydroxylase Canis lupus familiaris 135-137 22883210-0 2013 Selective loss of noradrenaline exacerbates early cognitive dysfunction and synaptic deficits in APP/PS1 mice. Norepinephrine 18-31 amyloid beta (A4) precursor protein Mus musculus 97-104 15939797-0 2005 Norepinephrine induces lipolysis in beta1/beta2/beta3-adrenoceptor knockout mice. Norepinephrine 0-14 hemoglobin, beta adult major chain Mus musculus 36-41 15939797-0 2005 Norepinephrine induces lipolysis in beta1/beta2/beta3-adrenoceptor knockout mice. Norepinephrine 0-14 adrenergic receptor, beta 3 Mus musculus 48-66 15939797-2 2005 Norepinephrine and epinephrine act through three subtypes of beta-adrenoceptors (beta-AR) expressed in the adipocytes. Norepinephrine 0-14 adrenergic receptor, beta 3 Mus musculus 81-88 22875483-4 2013 Dopamine beta hydroxylase (DBH) is responsible for maintaining dopamine-to-norepinephrine ratio implicated in migraine pathophysiology. Norepinephrine 75-89 dopamine beta-hydroxylase Homo sapiens 0-25 16211406-1 2005 The non-neuronal monoamine transporters OCT1, OCT2 and EMT (human gene symbols SLC22A1-A3) efficiently transport a number of positively-charged monoamines and some small organic cations across the plasma membrane, and thus are implicated in the inactivation of released monoamine transmitters (e.g. noradrenaline, histamine, agmatine) in vivo. Norepinephrine 299-312 solute carrier family 22 member 2 Homo sapiens 46-50 16211406-1 2005 The non-neuronal monoamine transporters OCT1, OCT2 and EMT (human gene symbols SLC22A1-A3) efficiently transport a number of positively-charged monoamines and some small organic cations across the plasma membrane, and thus are implicated in the inactivation of released monoamine transmitters (e.g. noradrenaline, histamine, agmatine) in vivo. Norepinephrine 299-312 IL2 inducible T cell kinase Homo sapiens 55-58 15936529-2 2005 Noradrenaline (NA) is catabolized by monoamine oxidase A (MAOA) and cathecol-O-methyl transferase (COMT). Norepinephrine 0-13 monoamine oxidase A Homo sapiens 37-56 15936529-2 2005 Noradrenaline (NA) is catabolized by monoamine oxidase A (MAOA) and cathecol-O-methyl transferase (COMT). Norepinephrine 0-13 monoamine oxidase A Homo sapiens 58-62 22875483-4 2013 Dopamine beta hydroxylase (DBH) is responsible for maintaining dopamine-to-norepinephrine ratio implicated in migraine pathophysiology. Norepinephrine 75-89 dopamine beta-hydroxylase Homo sapiens 27-30 23375328-1 2013 INTRODUCTION: Renalase, an enzyme that cetabolyzes catecholamines, such as circulating adrenaline and noradrenaline, is released by the human kidney to regulate blood pressure. Norepinephrine 102-115 renalase, FAD dependent amine oxidase Homo sapiens 14-22 15964316-1 2005 Norepinephrine (NE) stimulates phospholipase D (PLD) activity via phospholipase A2-dependent arachidonic acid release in rabbit aortic vascular smooth muscle cells (VSMC). Norepinephrine 0-14 phospholipase A2 Oryctolagus cuniculus 66-82 22999823-6 2012 Labeling for dopamine-beta-hydroxylase (DBH; the enzyme involved in norepinephrine synthesis) in the ventromedial nucleus of the hypothalamus (VMH) was densest in females that acquired nest sites compared to spring-like females without nest sites or fall-like females. Norepinephrine 68-82 dopamine beta-hydroxylase Sturnus vulgaris 13-38 15762841-8 2005 In primary brown adipocytes from C/EBPbeta(-/-) mice, induction of gene expression by noradrenaline was preserved. Norepinephrine 86-99 CCAAT/enhancer binding protein (C/EBP), beta Mus musculus 33-42 15949713-0 2005 Gut-derived norepinephrine plays an important role in up-regulating IL-1beta and IL-10. Norepinephrine 12-26 interleukin 10 Rattus norvegicus 81-86 15929740-3 2005 We also studied the effects of altered body weight on expression of dopamine beta-hydroxylase (DBH), the enzyme that produces noradrenalin from dopamine. Norepinephrine 126-138 dopamine beta-hydroxylase (dopamine beta-monooxygenase) Ovis aries 68-93 15929740-3 2005 We also studied the effects of altered body weight on expression of dopamine beta-hydroxylase (DBH), the enzyme that produces noradrenalin from dopamine. Norepinephrine 126-138 dopamine beta-hydroxylase (dopamine beta-monooxygenase) Ovis aries 95-98 15857612-5 2005 Ca(2+) sensitization induced by phenylephrine, norepinephrine and carbachol was markedly antagonized by all three ROK inhibitors. Norepinephrine 47-61 Rho-associated coiled-coil containing protein kinase 2 Rattus norvegicus 114-117 22999823-6 2012 Labeling for dopamine-beta-hydroxylase (DBH; the enzyme involved in norepinephrine synthesis) in the ventromedial nucleus of the hypothalamus (VMH) was densest in females that acquired nest sites compared to spring-like females without nest sites or fall-like females. Norepinephrine 68-82 dopamine beta-hydroxylase Sturnus vulgaris 40-43 22593004-0 2012 ATP and noradrenaline activate CREB in astrocytes via noncanonical Ca(2+) and cyclic AMP independent pathways. Norepinephrine 8-21 cAMP responsive element binding protein 1 Rattus norvegicus 31-35 22593004-4 2012 Here we sought to determine whether and how ATP and noradrenaline cause CREB-dependent transcription in rat cortical astrocyte cultures. Norepinephrine 52-65 cAMP responsive element binding protein 1 Rattus norvegicus 72-76 22593004-8 2012 We conclude that ATP and noradrenaline activate CREB-dependent transcription in cortical astrocytes via an atypical protein kinase C. It is of relevance that the signaling involved be starkly different to the one described in neurons since there is no convergence of Ca(2+) and cyclic AMP-dependent pathways on CRTC, which, moreover, exerts a modulatory rather than a central role. Norepinephrine 25-38 cAMP responsive element binding protein 1 Rattus norvegicus 48-52 22771532-7 2012 This revealed that Bergmann glia lacking type 2 IP(3)R exhibited reduced responses to noradrenaline or histamine compared with wild-type Bergmann glia and Bergmann glia with other genotypes, suggesting that type 2 IP(3)R is the major functional IP(3)R subtype involved in agonist-induced Ca(2+) release in Bergmann glia, although types 1 and 3 IP(3)R could also contribute to rapid agonist-induced [Ca(2+)](i) elevation in the processes. Norepinephrine 86-99 inositol 1,4,5-trisphosphate receptor 1 Mus musculus 48-54 15647328-1 2005 Using a guinea pig heart synaptosomal preparation, we previously observed that norepinephrine (NE) exocytosis was attenuated by a blockade of P2X purinoceptors, potentiated by inhibition of ectonucleoside triphosphate diphosphohydrolase-1 (E-NTPDase1)/CD39, and reduced by soluble CD39, a recombinant form of human E-NTPDase1/CD39. Norepinephrine 79-93 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 281-285 15647328-1 2005 Using a guinea pig heart synaptosomal preparation, we previously observed that norepinephrine (NE) exocytosis was attenuated by a blockade of P2X purinoceptors, potentiated by inhibition of ectonucleoside triphosphate diphosphohydrolase-1 (E-NTPDase1)/CD39, and reduced by soluble CD39, a recombinant form of human E-NTPDase1/CD39. Norepinephrine 79-93 ectonucleoside triphosphate diphosphohydrolase 1 Cavia porcellus 315-325 15647328-1 2005 Using a guinea pig heart synaptosomal preparation, we previously observed that norepinephrine (NE) exocytosis was attenuated by a blockade of P2X purinoceptors, potentiated by inhibition of ectonucleoside triphosphate diphosphohydrolase-1 (E-NTPDase1)/CD39, and reduced by soluble CD39, a recombinant form of human E-NTPDase1/CD39. Norepinephrine 79-93 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 281-285 15647328-2 2005 This suggests that norepinephrine and ATP are coreleased upon depolarization of cardiac sympathetic nerve endings and that ATP enhances norepinephrine exocytosis by an action modulated by E-NTPDase1/CD39 activity. Norepinephrine 19-33 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 199-203 15647328-2 2005 This suggests that norepinephrine and ATP are coreleased upon depolarization of cardiac sympathetic nerve endings and that ATP enhances norepinephrine exocytosis by an action modulated by E-NTPDase1/CD39 activity. Norepinephrine 136-150 ectonucleoside triphosphate diphosphohydrolase 1 Cavia porcellus 188-198 15647328-2 2005 This suggests that norepinephrine and ATP are coreleased upon depolarization of cardiac sympathetic nerve endings and that ATP enhances norepinephrine exocytosis by an action modulated by E-NTPDase1/CD39 activity. Norepinephrine 136-150 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 199-203 15647328-4 2005 We report that E-NTPDase1/CD39 is selectively localized in human and porcine cardiac neurons and that depolarization of porcine heart tissue elicits omega-conotoxin-inhibitable release of both norepinephrine and ATP. Norepinephrine 193-207 ectonucleoside triphosphate diphosphohydrolase 1 Cavia porcellus 15-25 15647328-4 2005 We report that E-NTPDase1/CD39 is selectively localized in human and porcine cardiac neurons and that depolarization of porcine heart tissue elicits omega-conotoxin-inhibitable release of both norepinephrine and ATP. Norepinephrine 193-207 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 26-30 22771532-7 2012 This revealed that Bergmann glia lacking type 2 IP(3)R exhibited reduced responses to noradrenaline or histamine compared with wild-type Bergmann glia and Bergmann glia with other genotypes, suggesting that type 2 IP(3)R is the major functional IP(3)R subtype involved in agonist-induced Ca(2+) release in Bergmann glia, although types 1 and 3 IP(3)R could also contribute to rapid agonist-induced [Ca(2+)](i) elevation in the processes. Norepinephrine 86-99 inositol 1,4,5-trisphosphate receptor 1 Mus musculus 214-220 15809019-12 2005 Myocardial content of noradrenaline was lower in the GFAP-bGH group (p<0.05). Norepinephrine 22-35 glial fibrillary acidic protein Mus musculus 53-57 22771532-7 2012 This revealed that Bergmann glia lacking type 2 IP(3)R exhibited reduced responses to noradrenaline or histamine compared with wild-type Bergmann glia and Bergmann glia with other genotypes, suggesting that type 2 IP(3)R is the major functional IP(3)R subtype involved in agonist-induced Ca(2+) release in Bergmann glia, although types 1 and 3 IP(3)R could also contribute to rapid agonist-induced [Ca(2+)](i) elevation in the processes. Norepinephrine 86-99 inositol 1,4,5-trisphosphate receptor 1 Mus musculus 214-220 22771532-7 2012 This revealed that Bergmann glia lacking type 2 IP(3)R exhibited reduced responses to noradrenaline or histamine compared with wild-type Bergmann glia and Bergmann glia with other genotypes, suggesting that type 2 IP(3)R is the major functional IP(3)R subtype involved in agonist-induced Ca(2+) release in Bergmann glia, although types 1 and 3 IP(3)R could also contribute to rapid agonist-induced [Ca(2+)](i) elevation in the processes. Norepinephrine 86-99 inositol 1,4,5-trisphosphate receptor 1 Mus musculus 214-220 21973085-6 2012 Similarly, in 3-month-old mice, caveolin-1 KO reduced contractility to noradrenaline by an L-NNA-sensitive mechanism. Norepinephrine 71-84 caveolin 1, caveolae protein Mus musculus 32-42 15814105-3 2005 Here, we have used in vivo microdialysis to compare the concentrations of extracellular noradrenaline ("efflux") in the cerebral cortex of anaesthetised NK1-/- and NK1+/+ mice. Norepinephrine 88-101 tachykinin 1 Mus musculus 153-156 15814105-6 2005 Basal noradrenaline efflux was increased 2 to 4-fold in NK1-/- mice compared with NK1+/+ mice but there was no difference in the effects of desipramine. Norepinephrine 6-19 tachykinin 1 Mus musculus 56-59 15715653-7 2005 The neuroprotective action of norepinephrine can be explained by (1) its ability to form complexes with Fe3+, (2) the uptake of Fe-norepinephrine complex via the norepinephrine transporter and (3) lack of toxicity of the Fe-norepinephrine complex even when DT-diaphorase is inhibited. Norepinephrine 30-44 solute carrier family 6 member 2 Rattus norvegicus 162-188 22816096-3 2012 Simultaneous addition of norepinephrine and peptides into the culture potentiated the expression of AANAT and pCREB. Norepinephrine 25-39 aralkylamine N-acetyltransferase Rattus norvegicus 100-105 15627480-8 2005 Both, reduced noradrenaline release in central nervous system induced with dexmedetomidine and central catecholamine depletion, as well as blockade of central alpha1-adrenoceptors induced with prazosin, all were associated with up-regulation of CYP1A1 expression. Norepinephrine 14-27 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 245-251 22890201-2 2012 Both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) regulate neurochemistry by degrading monoamine neurotransmitters (serotonin, dopamine, and norepinephrine). Norepinephrine 156-170 monoamine oxidase A Homo sapiens 5-24 15619008-5 2005 In contrast, spontaneous tumor cell migration is largely independent of non-muscle myosin II activity, whereas the norepinephrine-induced migration is completely inhibited by either direct inhibition of non-muscle myosin II or of the kinases phosphorylating the myosin light chain, namely ROCK or the calcium/calmodulin-dependent myosin light-chain kinase. Norepinephrine 115-129 myosin heavy chain 14 Homo sapiens 214-220 15619008-5 2005 In contrast, spontaneous tumor cell migration is largely independent of non-muscle myosin II activity, whereas the norepinephrine-induced migration is completely inhibited by either direct inhibition of non-muscle myosin II or of the kinases phosphorylating the myosin light chain, namely ROCK or the calcium/calmodulin-dependent myosin light-chain kinase. Norepinephrine 115-129 myosin heavy chain 14 Homo sapiens 214-220 15619008-5 2005 In contrast, spontaneous tumor cell migration is largely independent of non-muscle myosin II activity, whereas the norepinephrine-induced migration is completely inhibited by either direct inhibition of non-muscle myosin II or of the kinases phosphorylating the myosin light chain, namely ROCK or the calcium/calmodulin-dependent myosin light-chain kinase. Norepinephrine 115-129 myosin heavy chain 14 Homo sapiens 214-220 15813642-8 2005 Furthermore, antagonism or genetic inactivation of the NK1R causes alterations in serotonin and norepinephrine neuronal transmission that are likely to contribute to the antidepressant/anxiolytic activity of NK1R antagonists but that are--at least partially--distinct from those produced by established antidepressant drugs. Norepinephrine 96-110 tachykinin receptor 1 Homo sapiens 55-59 15813642-8 2005 Furthermore, antagonism or genetic inactivation of the NK1R causes alterations in serotonin and norepinephrine neuronal transmission that are likely to contribute to the antidepressant/anxiolytic activity of NK1R antagonists but that are--at least partially--distinct from those produced by established antidepressant drugs. Norepinephrine 96-110 tachykinin receptor 1 Homo sapiens 208-212 15306634-0 2005 Histamine H3-receptor-induced attenuation of norepinephrine exocytosis: a decreased protein kinase a activity mediates a reduction in intracellular calcium. Norepinephrine 45-59 histamine receptor H3 Homo sapiens 0-21 22890201-2 2012 Both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) regulate neurochemistry by degrading monoamine neurotransmitters (serotonin, dopamine, and norepinephrine). Norepinephrine 156-170 monoamine oxidase A Homo sapiens 26-31 20641293-2 2004 MAO-A preferentially oxidizes serotonin and noradrenaline, whereas MAO-B preferentially oxidizes phenethylamine. Norepinephrine 44-57 monoamine oxidase A Homo sapiens 0-5 22197914-5 2012 Additionally, the monoamine neurotransmitters serotonin (5-HT), noradrenaline (NA) and dopamine (DA) levels involved in the antidepressant-like effect of HCE were also measured in the mice brain regions of frontal cortex and hippocampus. Norepinephrine 64-77 RNA guanylyltransferase and 5'-phosphatase Mus musculus 154-157 15561429-1 2005 The norepinephrine transporter (NET) plays a major role in regulating the actions of norepinephrine by removing norepinephrine from the synapse. Norepinephrine 85-99 solute carrier family 6 member 2 Rattus norvegicus 4-30 22899923-10 2012 The SLIT2 SNP rs1379659 and the FAM5C SNP rs1935881 were associated with norepinephrine change during exercise. Norepinephrine 73-87 slit guidance ligand 2 Homo sapiens 4-9 22899923-11 2012 Finally, the OPRM1 SNP rs1799971 was related to changes in norepinephrine, lactate, and rate of perceived exertion (RPE) during exercise. Norepinephrine 59-73 opioid receptor mu 1 Homo sapiens 13-18 22761865-3 2012 The dopamine beta hydroxylase (DBH) gene is thought to regulate the differential availability of dopamine and norepinephrine in prefrontal cortex. Norepinephrine 110-124 dopamine beta-hydroxylase Homo sapiens 4-29 15796803-3 2005 The dopamine beta hydroxylase (DbetaH) is the key enzyme to ADHD since it catalyzes the conversion of dopamine to norepinephrine, and dysfunction there of is believed to be one of the causes of the disorder. Norepinephrine 114-128 dopamine beta-hydroxylase Homo sapiens 4-29 15613462-8 2004 Over-expression of the hypoxia-inducible transcription factor, HIF-2alpha, in norepinephrine-predominant sporadic and VHL tumors compared with epinephrine-producing tumors indicates that expression of this gene depends on the noradrenergic biochemical phenotype. Norepinephrine 78-92 endothelial PAS domain protein 1 Homo sapiens 63-73 15613462-9 2004 The findings fit with the known expression of HIF-2alpha in norepinephrine-producing cells of the sympathetic nervous system and might explain both the development and noradrenergic biochemical phenotype of pheochromocytomas in VHL syndrome. Norepinephrine 60-74 endothelial PAS domain protein 1 Homo sapiens 46-56 15599324-4 2004 The univariate analysis demonstrated that CCL2/MCP-1 release was significantly associated with the surgical team in charge for organ harvesting, the proteins for dilution solution, the type of gradient, the type of enzyme, and the donor noradrenalin treatment. Norepinephrine 237-249 C-C motif chemokine ligand 2 Homo sapiens 42-46 15599324-4 2004 The univariate analysis demonstrated that CCL2/MCP-1 release was significantly associated with the surgical team in charge for organ harvesting, the proteins for dilution solution, the type of gradient, the type of enzyme, and the donor noradrenalin treatment. Norepinephrine 237-249 C-C motif chemokine ligand 2 Homo sapiens 47-52 15500961-8 2004 Epinephrine, norepinephrine and octopamine also weakly inhibited macroscopic currents at NR1/NR2A and NR1/NR2B receptors. Norepinephrine 13-27 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 89-92 15500961-8 2004 Epinephrine, norepinephrine and octopamine also weakly inhibited macroscopic currents at NR1/NR2A and NR1/NR2B receptors. Norepinephrine 13-27 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 102-105 15500961-8 2004 Epinephrine, norepinephrine and octopamine also weakly inhibited macroscopic currents at NR1/NR2A and NR1/NR2B receptors. Norepinephrine 13-27 glutamate receptor ionotropic, NMDA 2B Xenopus laevis 106-110 22761865-3 2012 The dopamine beta hydroxylase (DBH) gene is thought to regulate the differential availability of dopamine and norepinephrine in prefrontal cortex. Norepinephrine 110-124 dopamine beta-hydroxylase Homo sapiens 31-34 20641715-8 2004 In noradrenergic neurons, dopamine is converted to norepinephrine (NE) by dopamine beta-hydroxylase (DBH) and stored in vesicles in the neurons (4). Norepinephrine 51-65 dopamine beta-hydroxylase Homo sapiens 74-99 15313455-4 2004 Sympathetic nerve endings release noradrenaline (NA) in the proximity of brown fat cells, where noradrenaline activates G-protein-coupled beta-adrenergic receptors (AR) and by doing so initiates a cascade of metabolic events culminating in the activation of uncoupling protein 1 (UCP1). Norepinephrine 34-47 uncoupling protein 1 Homo sapiens 258-278 15313455-4 2004 Sympathetic nerve endings release noradrenaline (NA) in the proximity of brown fat cells, where noradrenaline activates G-protein-coupled beta-adrenergic receptors (AR) and by doing so initiates a cascade of metabolic events culminating in the activation of uncoupling protein 1 (UCP1). Norepinephrine 34-47 uncoupling protein 1 Homo sapiens 280-284 15313455-4 2004 Sympathetic nerve endings release noradrenaline (NA) in the proximity of brown fat cells, where noradrenaline activates G-protein-coupled beta-adrenergic receptors (AR) and by doing so initiates a cascade of metabolic events culminating in the activation of uncoupling protein 1 (UCP1). Norepinephrine 96-109 uncoupling protein 1 Homo sapiens 258-278 15313455-4 2004 Sympathetic nerve endings release noradrenaline (NA) in the proximity of brown fat cells, where noradrenaline activates G-protein-coupled beta-adrenergic receptors (AR) and by doing so initiates a cascade of metabolic events culminating in the activation of uncoupling protein 1 (UCP1). Norepinephrine 96-109 uncoupling protein 1 Homo sapiens 280-284 15662096-1 2004 Dopamine beta-hydroxylase (DBH) which catalyzes conversion of dopamine into noradrenaline, may be a good blood marker of unipolar depression. Norepinephrine 76-89 dopamine beta-hydroxylase Rattus norvegicus 0-25 15662096-1 2004 Dopamine beta-hydroxylase (DBH) which catalyzes conversion of dopamine into noradrenaline, may be a good blood marker of unipolar depression. Norepinephrine 76-89 dopamine beta-hydroxylase Rattus norvegicus 27-30 15293052-11 2004 We conclude that the effect of training on the response of noradrenaline to exercise seems to be involved in the delay in the normalization of leptin levels. Norepinephrine 59-72 leptin Homo sapiens 143-149 15293052-12 2004 We suggest that the amplitude of the noradrenaline response to exercise induced an increase in fat use and a rapid leptin recovery after exercise. Norepinephrine 37-50 leptin Homo sapiens 115-121 20641715-8 2004 In noradrenergic neurons, dopamine is converted to norepinephrine (NE) by dopamine beta-hydroxylase (DBH) and stored in vesicles in the neurons (4). Norepinephrine 51-65 dopamine beta-hydroxylase Homo sapiens 101-104 21963947-1 2011 Having previously observed that noradrenaline activation of beta adrenergic receptors induces the synthesis of the chemokine monocyte chemoattractant protein (CCL2/MCP-1) in astrocytes, it is our interest to analyze the mechanisms involved in this process, particularly the possible effect of noradrenaline-modulating drugs. Norepinephrine 32-45 C-C motif chemokine ligand 2 Rattus norvegicus 159-163 15276785-1 2004 Previous work using the retrogradely transported immunotoxin, saporin (SAP) conjugated to a monoclonal antibody against dopamine-beta-hydroxylase (DBH; DSAP), to selectively lesion norepinephrine (NE) and epinephrine (E) neurons projecting to the medial hypothalamus, demonstrated the essential role of these neurons for appetitive ingestive responses to glucoprivation. Norepinephrine 181-195 dopamine beta-hydroxylase Rattus norvegicus 120-145 15276785-1 2004 Previous work using the retrogradely transported immunotoxin, saporin (SAP) conjugated to a monoclonal antibody against dopamine-beta-hydroxylase (DBH; DSAP), to selectively lesion norepinephrine (NE) and epinephrine (E) neurons projecting to the medial hypothalamus, demonstrated the essential role of these neurons for appetitive ingestive responses to glucoprivation. Norepinephrine 181-195 dopamine beta-hydroxylase Rattus norvegicus 147-150 21963947-1 2011 Having previously observed that noradrenaline activation of beta adrenergic receptors induces the synthesis of the chemokine monocyte chemoattractant protein (CCL2/MCP-1) in astrocytes, it is our interest to analyze the mechanisms involved in this process, particularly the possible effect of noradrenaline-modulating drugs. Norepinephrine 32-45 C-C motif chemokine ligand 2 Rattus norvegicus 164-169 15356201-0 2004 Uptake and release of norepinephrine by serotonergic terminals in norepinephrine transporter knock-out mice: implications for the action of selective serotonin reuptake inhibitors. Norepinephrine 22-36 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 66-92 21963947-1 2011 Having previously observed that noradrenaline activation of beta adrenergic receptors induces the synthesis of the chemokine monocyte chemoattractant protein (CCL2/MCP-1) in astrocytes, it is our interest to analyze the mechanisms involved in this process, particularly the possible effect of noradrenaline-modulating drugs. Norepinephrine 293-306 C-C motif chemokine ligand 2 Rattus norvegicus 159-163 21963947-1 2011 Having previously observed that noradrenaline activation of beta adrenergic receptors induces the synthesis of the chemokine monocyte chemoattractant protein (CCL2/MCP-1) in astrocytes, it is our interest to analyze the mechanisms involved in this process, particularly the possible effect of noradrenaline-modulating drugs. Norepinephrine 293-306 C-C motif chemokine ligand 2 Rattus norvegicus 164-169 15193150-0 2004 Noradrenaline represses PPAR (peroxisome-proliferator-activated receptor) gamma2 gene expression in brown adipocytes: intracellular signalling and effects on PPARgamma2 and PPARgamma1 protein levels. Norepinephrine 0-13 peroxisome proliferator activated receptor alpha Homo sapiens 24-28 21963947-6 2011 While the activation of beta adrenergic receptors and the subsequent elevation of cAMP levels seem to be the main pathway for noradrenaline to induce CCL2/MCP-1 in astrocytes, our data indicate that the alpha2 adrenergic receptors also regulate CCL2/MCP-1 expression working as inhibitory mediators. Norepinephrine 126-139 C-C motif chemokine ligand 2 Rattus norvegicus 150-154 15262904-6 2004 Blockade of norepinephrine transporter or alpha2-adrenoceptors using desipramine or rauwolscine reduced the losartan-induced shifts in the ED50 values of noradrenaline by 63% and 21%, respectively. Norepinephrine 154-167 solute carrier family 6 member 2 Rattus norvegicus 12-38 21963947-6 2011 While the activation of beta adrenergic receptors and the subsequent elevation of cAMP levels seem to be the main pathway for noradrenaline to induce CCL2/MCP-1 in astrocytes, our data indicate that the alpha2 adrenergic receptors also regulate CCL2/MCP-1 expression working as inhibitory mediators. Norepinephrine 126-139 C-C motif chemokine ligand 2 Rattus norvegicus 155-160 15262904-7 2004 Combined blockade of norepinephrine transporter and alpha2-adrenoceptors eliminated the influence of losartan on noradrenaline sensitivity (ED50 5.5+/-1.3 versus 5.6+/-1.2 nmol/kg), a result also observed after sympathetic denervation by reserpine (ED50 7.1+/-0.8 versus 7.8+/-0.8 nmol/kg). Norepinephrine 113-126 solute carrier family 6 member 2 Rattus norvegicus 21-47 15262904-8 2004 Our experiments show that the reduction of vascular noradrenaline sensitivity by AT1 blockade is dependent on the intact functioning of both neuronal noradrenaline uptake via norepinephrine transporter and presynaptic alpha2-mediated autoinhibition, exclusively provided by the sympathetic innervation. Norepinephrine 52-65 solute carrier family 6 member 2 Rattus norvegicus 175-201 21963947-6 2011 While the activation of beta adrenergic receptors and the subsequent elevation of cAMP levels seem to be the main pathway for noradrenaline to induce CCL2/MCP-1 in astrocytes, our data indicate that the alpha2 adrenergic receptors also regulate CCL2/MCP-1 expression working as inhibitory mediators. Norepinephrine 126-139 C-C motif chemokine ligand 2 Rattus norvegicus 245-249 15262904-8 2004 Our experiments show that the reduction of vascular noradrenaline sensitivity by AT1 blockade is dependent on the intact functioning of both neuronal noradrenaline uptake via norepinephrine transporter and presynaptic alpha2-mediated autoinhibition, exclusively provided by the sympathetic innervation. Norepinephrine 150-163 solute carrier family 6 member 2 Rattus norvegicus 175-201 21963947-6 2011 While the activation of beta adrenergic receptors and the subsequent elevation of cAMP levels seem to be the main pathway for noradrenaline to induce CCL2/MCP-1 in astrocytes, our data indicate that the alpha2 adrenergic receptors also regulate CCL2/MCP-1 expression working as inhibitory mediators. Norepinephrine 126-139 C-C motif chemokine ligand 2 Rattus norvegicus 250-255 21708146-11 2011 The mechanism involved in both cases is that SAMe is required for the conversion of epinephrine from norepinephrine by phenylethanolamine methyltransferase (PNMT). Norepinephrine 101-115 phenylethanolamine-N-methyltransferase Rattus norvegicus 119-155 21708146-11 2011 The mechanism involved in both cases is that SAMe is required for the conversion of epinephrine from norepinephrine by phenylethanolamine methyltransferase (PNMT). Norepinephrine 101-115 phenylethanolamine-N-methyltransferase Rattus norvegicus 157-161 21784415-2 2011 In the brain, ALDH1A1 participates in the metabolism of catecholamines including dopamine (DA) and norepinephrine, but is uniquely expressed in a subset of dopaminergic (DAergic) neurons in the ventral mesencephalon where it converts 3,4-dihydroxyphenylacetaldehyde, a potentially toxic aldehyde, to 3,4-dihydroxyphenylacetic acid, a non toxic metabolite. Norepinephrine 99-113 aldehyde dehydrogenase 1 family member A1 Homo sapiens 14-21 21377513-0 2011 Norepinephrine and ss1-adrenergic signaling facilitate activation of hippocampal CA1 pyramidal neurons during contextual memory retrieval. Norepinephrine 0-14 carbonic anhydrase 1 Mus musculus 81-84 21354320-9 2011 A selective sGC inhibitor, ODQ (3muM), prevented the endotoxin-induced decrease in the E(max) values and increase in the EC(50) values of norepinephrine in endothelium-intact aortic rings isolated from endotoxemic rats in vitro. Norepinephrine 138-152 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 12-15 21247719-5 2011 A good linear relationship with coefficients >=0.99 was achieved over the concentration ranges of 10-1000ngmL(-1) for 5-hydroxytryptamine (5-HT) and norepinephrine (NE); 2-250ngmL(-1) for methionine-enkephalin (M-ENK) and leucine-enkephalin (L-ENK). Norepinephrine 152-166 proenkephalin Rattus norvegicus 202-212 21247719-5 2011 A good linear relationship with coefficients >=0.99 was achieved over the concentration ranges of 10-1000ngmL(-1) for 5-hydroxytryptamine (5-HT) and norepinephrine (NE); 2-250ngmL(-1) for methionine-enkephalin (M-ENK) and leucine-enkephalin (L-ENK). Norepinephrine 152-166 proenkephalin Rattus norvegicus 216-219 21247719-5 2011 A good linear relationship with coefficients >=0.99 was achieved over the concentration ranges of 10-1000ngmL(-1) for 5-hydroxytryptamine (5-HT) and norepinephrine (NE); 2-250ngmL(-1) for methionine-enkephalin (M-ENK) and leucine-enkephalin (L-ENK). Norepinephrine 152-166 proenkephalin Rattus norvegicus 247-250 21185902-6 2011 Increased functioning of noradrenaline (along with other central and peripheral regulating mechanisms) may be an important factor associated with cardiovascular changes in AWS. Norepinephrine 25-38 jagged canonical Notch ligand 1 Homo sapiens 172-175 21272571-6 2011 Clobenpropit (histamine H(3) receptor antagonist, 1muM) canceled the alpha-methylhistamine-induced decrease in the periarterial nerve stimulation-induced vasoconstriction and noradrenaline release and periarterial nerve stimulation-induced vasodilation. Norepinephrine 175-188 histamine receptor H3 Rattus norvegicus 14-37 15363607-0 2004 Noradrenaline storage function of species-specific protein bodies, markers of monoamine neurons in human locus coeruleus demonstrated by dopamine-beta-hydroxylase immunogold localization. Norepinephrine 0-13 dopamine beta-hydroxylase Homo sapiens 137-162 15363607-7 2004 Since dopamine-beta-hydroxylase (DBH) is a hallmark of noradrenaline identity and present in dense core vesicles, the investigation of DBH localization with the immunogold method constituted the experiment of choice for this study. Norepinephrine 55-68 dopamine beta-hydroxylase Homo sapiens 6-31 15363607-7 2004 Since dopamine-beta-hydroxylase (DBH) is a hallmark of noradrenaline identity and present in dense core vesicles, the investigation of DBH localization with the immunogold method constituted the experiment of choice for this study. Norepinephrine 55-68 dopamine beta-hydroxylase Homo sapiens 33-36 15213629-12 2004 CONCLUSIONS: Depletion of norepinephrine attenuated burn and burn sepsis-induced bone marrow progenitor clonal growth in response to macrophage- and granulocyte-macrophage colony-stimulating factor. Norepinephrine 26-40 colony stimulating factor 2 Homo sapiens 133-197 15189762-0 2004 Resistin, but not adiponectin, inhibits dopamine and norepinephrine release in the hypothalamus. Norepinephrine 53-67 resistin Homo sapiens 0-8 15189762-5 2004 We have found that adiponectin does not modify either basal or depolarization-induced amine release, while resistin inhibits the stimulated release of dopamine and norepinephrine, leaving unaffected serotonin release. Norepinephrine 164-178 resistin Homo sapiens 107-115 21297130-4 2011 In C57BL/6 mice immunized with myelin oligodendrocyte glycoprotein peptide 35-55 to develop chronic disease, cortical and spinal cord levels of noradrenaline were significantly reduced versus control mice. Norepinephrine 144-157 myelin oligodendrocyte glycoprotein Mus musculus 31-66 21288809-3 2011 We demonstrate that haploinsufficiency for the O(2)-regulated HIF-2alpha subunit results in augmented carotid body sensitivity to hypoxia, irregular breathing, apneas, hypertension, and elevated plasma norepinephrine levels in adult Hif-2alpha(+/-) mice. Norepinephrine 202-216 endothelial PAS domain protein 1 Mus musculus 62-72 15240349-0 2004 Brain circuits involved in corticotropin-releasing factor-norepinephrine interactions during stress. Norepinephrine 58-72 corticotropin releasing hormone Homo sapiens 27-57 15020588-9 2004 With aortic rings (without endothelium) preconstricted by high K(+) saline or by the alpha-adrenergic agonist norepinephrine, CFTR activators produced a concentration-dependent relaxation. Norepinephrine 110-124 CF transmembrane conductance regulator Rattus norvegicus 126-130 14722031-5 2004 Total and renal norepinephrine spillover rates correlated directly with whole body leptin secretion rate. Norepinephrine 16-30 leptin Homo sapiens 83-89 15044095-1 2004 Conversion of neurotransmitter dopamine into norepinephrine is catalyzed by dopamine beta-hydroxylase (DbH). Norepinephrine 45-59 dopamine beta-hydroxylase Homo sapiens 76-101 15044095-1 2004 Conversion of neurotransmitter dopamine into norepinephrine is catalyzed by dopamine beta-hydroxylase (DbH). Norepinephrine 45-59 dopamine beta-hydroxylase Homo sapiens 103-106 21131476-8 2011 BK beta1-KO mesenteric arteries in vitro demonstrated diminished contractile responses to paxilline, increased reactivity to Bay K 8644 and norepinephrine (NE), and maintained relaxation to isoproterenol. Norepinephrine 140-154 potassium large conductance calcium-activated channel, subfamily M, beta member 1 Mus musculus 0-8 21297953-8 2011 Renal expression of renalase was reduced (protein: 0.476+-0.043 for control, 0.248+-0.029 for operation versus 0.636+-0.151 for sham-operation) and this was associated with an increase in circulating norepinephrine (0.168+-0.016 ng/mL for control, 0.203+-0.019 ng/mL for operation versus 0.138+-0.008 ng/mL for sham-operation). Norepinephrine 200-214 renalase, FAD-dependent amine oxidase Rattus norvegicus 20-28 21297953-9 2011 CONCLUSIONS/SIGNIFICANCE: Renalase expression is influenced by renal blood flow and impaired synthesis of renalase by the kidney may represent a potential mechanism underlying circulating norepinephrine accumulation in heart failure. Norepinephrine 188-202 renalase, FAD-dependent amine oxidase Rattus norvegicus 26-34 21297953-9 2011 CONCLUSIONS/SIGNIFICANCE: Renalase expression is influenced by renal blood flow and impaired synthesis of renalase by the kidney may represent a potential mechanism underlying circulating norepinephrine accumulation in heart failure. Norepinephrine 188-202 renalase, FAD-dependent amine oxidase Rattus norvegicus 106-114 22216270-13 2011 Pretreatment with pH 5.0 QX-314, and not pH 7.4 QX-314, alleviated pain behavior, inhibited the increased spinal Fos protein and p-ERK expression induced by pH 5.0 PBS or norepinephrine, blocked sodium currents and abolished the production of action potentials evoked by current injection. Norepinephrine 171-185 FBJ osteosarcoma oncogene Mus musculus 113-116 21625389-6 2011 Our results suggest that norepinephrine activity can be further decreased, giving rise to a strong own song selective signal in dorsal NCM. Norepinephrine 25-39 CWC22 spliceosome associated protein homolog Homo sapiens 135-138 20926777-0 2010 Identification and functional implication of a Rho kinase-dependent moesin-EBP50 interaction in noradrenaline-stimulated artery. Norepinephrine 96-109 SLC9A3 regulator 1 Rattus norvegicus 75-80 20926777-5 2010 Immunoprecipitation of EBP50 in noradrenaline-stimulated arteries allowed identification of its interaction with moesin and several other proteins involved in cytoskeleton regulation. Norepinephrine 32-45 SLC9A3 regulator 1 Rattus norvegicus 23-28 21070631-2 2010 Dopamine beta-hydroxylase (DBH) catalyses the conversion of dopamine to noradrenaline. Norepinephrine 72-85 dopamine beta-hydroxylase Homo sapiens 0-25 21070631-2 2010 Dopamine beta-hydroxylase (DBH) catalyses the conversion of dopamine to noradrenaline. Norepinephrine 72-85 dopamine beta-hydroxylase Homo sapiens 27-30 20679667-5 2010 Affected males in this family showed an inherited hemizygous deletion restricted to NDP and two immediately telomeric genes, monoamine oxidase-B (MAO-B) and monoamine oxidase-A (MAO-A), which encode closely related enzymes that metabolize biogenic amines including serotonin, dopamine, and norepinephrine. Norepinephrine 290-304 monoamine oxidase A Homo sapiens 157-176 20679667-5 2010 Affected males in this family showed an inherited hemizygous deletion restricted to NDP and two immediately telomeric genes, monoamine oxidase-B (MAO-B) and monoamine oxidase-A (MAO-A), which encode closely related enzymes that metabolize biogenic amines including serotonin, dopamine, and norepinephrine. Norepinephrine 290-304 monoamine oxidase A Homo sapiens 178-183 20728435-5 2010 A small number of HSD2 immunoreactive neurons was also labeled for dopamine-beta-hydroxylase (DBH), an enzyme involved in norepinephrine biosynthesis. Norepinephrine 122-136 dopamine beta-hydroxylase Rattus norvegicus 67-92 20937870-2 2010 During the fight-or-flight response, epinephrine released by the adrenal medulla and norepinephrine released from sympathetic nerves increase muscle contractility by activation of the beta-adrenergic receptor/cAMP-dependent protein kinase pathway and up-regulation of Ca(V)1 channels in skeletal and cardiac muscle. Norepinephrine 85-99 caveolin-1 Oryctolagus cuniculus 268-274 14617573-3 2004 Treatment of pinealocytes with norepinephrine (NE) caused a time-dependent increase in the levels of AA-NAT mRNA, AA-NAT protein, and enzymatic activity as well as MT production. Norepinephrine 31-45 aralkylamine N-acetyltransferase Rattus norvegicus 101-107 14617573-3 2004 Treatment of pinealocytes with norepinephrine (NE) caused a time-dependent increase in the levels of AA-NAT mRNA, AA-NAT protein, and enzymatic activity as well as MT production. Norepinephrine 31-45 aralkylamine N-acetyltransferase Rattus norvegicus 114-120 14757141-0 2004 Tonic inhibition by orphanin FQ/nociceptin of noradrenaline neurotransmission in the amygdala. Norepinephrine 46-59 prepronociceptin Rattus norvegicus 20-31 14757141-0 2004 Tonic inhibition by orphanin FQ/nociceptin of noradrenaline neurotransmission in the amygdala. Norepinephrine 46-59 prepronociceptin Rattus norvegicus 32-42 14757141-1 2004 The present microdialysis study investigated whether nociceptin/orphanin FQ exerts a tonic inhibition of the release of noradrenaline in the basolateral nucleus of the amygdala in awake rats. Norepinephrine 120-133 prepronociceptin Rattus norvegicus 53-63 14757141-1 2004 The present microdialysis study investigated whether nociceptin/orphanin FQ exerts a tonic inhibition of the release of noradrenaline in the basolateral nucleus of the amygdala in awake rats. Norepinephrine 120-133 prepronociceptin Rattus norvegicus 64-75 14757141-5 2004 Local infusion of nociceptin/orphanin FQ (1 microM) itself reduced noradrenaline release in the basolateral nucleus of the amygdala to about 70% of basal levels. Norepinephrine 67-80 prepronociceptin Rattus norvegicus 18-28 14757141-5 2004 Local infusion of nociceptin/orphanin FQ (1 microM) itself reduced noradrenaline release in the basolateral nucleus of the amygdala to about 70% of basal levels. Norepinephrine 67-80 prepronociceptin Rattus norvegicus 29-40 14757141-6 2004 These results indicate that a large part of basal release of noradrenaline in the basolateral nucleus of the amygdala is under tonic inhibitory control by endogenous nociceptin/orphanin FQ through the N/OFQ peptide receptors localized within the basolateral nucleus of the amygdala. Norepinephrine 61-74 prepronociceptin Rattus norvegicus 166-176 14729385-2 2004 An extensive body of evidence shows that activation of the histamine H3 receptor attenuates sympathetic tone by presynaptic inhibition of noradrenaline release. Norepinephrine 138-151 histamine receptor H3 Homo sapiens 59-80 14697876-10 2004 MAO-A oxidizes noradrenaline and serotonin; and MAO-B, mainly beta-phenylethylamine. Norepinephrine 15-28 monoamine oxidase A Homo sapiens 0-5 14697899-5 2004 The cheese reaction is a consequence of inhibition of MAO-A, the enzyme responsible for metabolism of noradrenaline and serotonin, located in peripheral adrenergic neurons. Norepinephrine 102-115 monoamine oxidase A Homo sapiens 54-59 20485326-1 2010 Monoamine oxidases (MAO-A and MAO-B) have a key role in the degradation of amine neurotransmitters, such as dopamine, norepinephrine and serotonin. Norepinephrine 118-132 monoamine oxidase A Homo sapiens 20-25 15003356-4 2004 Oxidized NPY, like native NPY, potentiated the noradrenaline and adenosine 5"-triphospahate-induced vasoconstriction, an effect blocked by BIBP 3226 and consonant with the RT-PCR detection of the mRNA encoding the NPY Y1 receptor. Norepinephrine 47-60 neuropeptide Y Homo sapiens 9-12 15003356-4 2004 Oxidized NPY, like native NPY, potentiated the noradrenaline and adenosine 5"-triphospahate-induced vasoconstriction, an effect blocked by BIBP 3226 and consonant with the RT-PCR detection of the mRNA encoding the NPY Y1 receptor. Norepinephrine 47-60 neuropeptide Y Homo sapiens 26-29 15003356-4 2004 Oxidized NPY, like native NPY, potentiated the noradrenaline and adenosine 5"-triphospahate-induced vasoconstriction, an effect blocked by BIBP 3226 and consonant with the RT-PCR detection of the mRNA encoding the NPY Y1 receptor. Norepinephrine 47-60 neuropeptide Y Homo sapiens 26-29 14506227-1 2003 Dopamine beta-hydroxylase (DBH) catalyzes the production of norepinephrine, and its expression defines the noradrenergic phenotype. Norepinephrine 60-74 dopamine beta-hydroxylase Homo sapiens 0-25 14506227-1 2003 Dopamine beta-hydroxylase (DBH) catalyzes the production of norepinephrine, and its expression defines the noradrenergic phenotype. Norepinephrine 60-74 dopamine beta-hydroxylase Homo sapiens 27-30 14508509-3 2003 Since monoamine oxidase A metabolises noradrenalin, a positive association with the MAOA gene would be biologically plausible. Norepinephrine 38-50 monoamine oxidase A Homo sapiens 6-25 14508509-3 2003 Since monoamine oxidase A metabolises noradrenalin, a positive association with the MAOA gene would be biologically plausible. Norepinephrine 38-50 monoamine oxidase A Homo sapiens 84-88 12423672-8 2002 An alpha2 agonist clonidine and dobutamine upregulated the expression of mRNA encoding catechol-O-methyl transferase, an important enzyme to degrade norepinephrine. Norepinephrine 149-163 catechol-O-methyltransferase Rattus norvegicus 87-116 20530737-9 2010 Principally in accordance with this, a higher than standard dose of norepinephrine was needed to obtain full norepinephrine-induced thermogenesis in the Cav1-ablated mice; the higher dose was also needed for the Cav1-ablated mice to be able to utilize fat as a substrate for thermogenesis. Norepinephrine 68-82 caveolin 1, caveolae protein Mus musculus 153-157 20530737-9 2010 Principally in accordance with this, a higher than standard dose of norepinephrine was needed to obtain full norepinephrine-induced thermogenesis in the Cav1-ablated mice; the higher dose was also needed for the Cav1-ablated mice to be able to utilize fat as a substrate for thermogenesis. Norepinephrine 68-82 caveolin 1, caveolae protein Mus musculus 212-216 20530737-9 2010 Principally in accordance with this, a higher than standard dose of norepinephrine was needed to obtain full norepinephrine-induced thermogenesis in the Cav1-ablated mice; the higher dose was also needed for the Cav1-ablated mice to be able to utilize fat as a substrate for thermogenesis. Norepinephrine 109-123 caveolin 1, caveolae protein Mus musculus 153-157 20810904-6 2010 Norepinephrine and isoproterenol upregulated the expression of Abeta receptor mFPR2, a mouse homolog of human formyl peptide receptor FPR2, through activation of beta(2)AR in microglia. Norepinephrine 0-14 formyl peptide receptor 2 Homo sapiens 79-83 20554938-3 2010 Expression of c-Fos protein was used as a marker for neuronal activation and dopamine-beta-hydroxylase (DBH), the enzyme-catalyzing noradrenaline synthesis, as a marker for noradrenergic neurons. Norepinephrine 132-145 dopamine beta-hydroxylase Rattus norvegicus 104-107 20641888-2 2004 In addition, the H3 receptor (H3R) is also known to regulate the synthesis and release of histamine itself and other neurotransmitters such as noradrenalin, dopamine, and acetylcholine (1, 2). Norepinephrine 143-155 histamine receptor H3 Homo sapiens 17-28 12475182-3 2002 Testosterone-treated cells showed fewer and smaller lipid droplets than control cells and a dose-dependent inhibition of UCP1 mRNA expression, under adrenergic stimulation by norepinephrine (NE). Norepinephrine 175-189 uncoupling protein 1 Homo sapiens 121-125 12241539-0 2002 The Trp64Arg beta3-adrenergic receptor amino acid variant confers increased sensitivity to the pressor effects of noradrenaline in Sardinian subjects. Norepinephrine 114-127 adrenoceptor beta 3 Homo sapiens 13-38 12241539-3 2002 The aim of the present study was to evaluate the effect of the Trp64Arg beta(3)AR variant on the regulation of triacylglycerol levels and blood pressure during the exogenous infusion of noradrenaline. Norepinephrine 186-199 adrenoceptor beta 3 Homo sapiens 72-81 12241539-11 2002 In conclusion, our data indicate that the Trp64Arg amino acid variant of the beta(3)AR confers increased sensitivity to the pressure effect of noradrenaline. Norepinephrine 143-156 adrenoceptor beta 3 Homo sapiens 77-86 12050158-0 2002 Norepinephrine increases I kappa B alpha expression in astrocytes. Norepinephrine 0-14 NFKB inhibitor alpha Rattus norvegicus 25-40 12176394-5 2002 When rat tail artery was treated with norepinephrine (10 mM), PLCbeta2 was shown to translocate from cytosol to membranes. Norepinephrine 38-52 phospholipase C, beta 2 Rattus norvegicus 62-70 12176394-8 2002 This evidence is consistent with the model wherein an agonist such as norepinephrine can activate smooth muscle contraction via interaction with a plasma membrane receptor which can easily interact with a plasma membrane-associated isoform of PLC, such as PLCbeta2. Norepinephrine 70-84 phospholipase C, beta 2 Rattus norvegicus 256-264 12193117-10 2002 We conclude from our results that dogs receiving the selective ET-A inhibitor ABT-627 seem to show a different hormonal response after haemorrhage compared with controls, displaying considerably higher noradrenaline concentrations. Norepinephrine 202-215 endothelin receptor type A Canis lupus familiaris 63-67 20641888-2 2004 In addition, the H3 receptor (H3R) is also known to regulate the synthesis and release of histamine itself and other neurotransmitters such as noradrenalin, dopamine, and acetylcholine (1, 2). Norepinephrine 143-155 histamine receptor H3 Homo sapiens 30-33 20642018-2 2004 MAO-A preferentially oxidizes serotonin and noradrenaline, whereas MAO-B preferentially oxidizes phenethylamine. Norepinephrine 44-57 monoamine oxidase A Homo sapiens 0-5 12074941-4 2002 The depressor response to human urotensin II (3 nmol/kg) was attenuated by approximately 50% in rats with MAP elevated through pretreatment with N(G)-nitro-L-arginine methyl ester (inhibitor of NO synthase), relative to that in rats with MAP elevated to a similar level through a continuous infusion of noradrenaline. Norepinephrine 303-316 urotensin 2 Homo sapiens 32-44 20374255-0 2010 Role of 5-HT 2B receptors in cardiomyocyte apoptosis in noradrenaline-induced cardiomyopathy in rats. Norepinephrine 56-69 5-hydroxytryptamine receptor 2B Rattus norvegicus 8-15 11965360-1 2002 Gene expression of phenylethanolamine N-methyltransferase (PNMT), the enzyme catalyzing conversion of norepinephrine to epinephrine, has been detected in rat spleen using the reverse transcription polymerase chain reaction. Norepinephrine 102-116 phenylethanolamine-N-methyltransferase Rattus norvegicus 19-57 11965360-1 2002 Gene expression of phenylethanolamine N-methyltransferase (PNMT), the enzyme catalyzing conversion of norepinephrine to epinephrine, has been detected in rat spleen using the reverse transcription polymerase chain reaction. Norepinephrine 102-116 phenylethanolamine-N-methyltransferase Rattus norvegicus 59-63 11943777-1 2002 The homeodomain transcription factor Arix/Phox2a plays a critical role in the specification of noradrenergic neurons by inducing the expression of dopamine beta-hydroxylase (DBH), the terminal enzyme for noradrenaline biosynthesis. Norepinephrine 204-217 dopamine beta-hydroxylase Homo sapiens 147-172 11943777-1 2002 The homeodomain transcription factor Arix/Phox2a plays a critical role in the specification of noradrenergic neurons by inducing the expression of dopamine beta-hydroxylase (DBH), the terminal enzyme for noradrenaline biosynthesis. Norepinephrine 204-217 dopamine beta-hydroxylase Homo sapiens 174-177 12059116-1 2002 Adrenergic receptors mediate the central and peripheral actions of norepinephrine and epinephrine and are pharmacologically divided into three major types, alpha-1, alpha-2, and beta. Norepinephrine 67-81 adrenoceptor alpha 1D Homo sapiens 156-163 11919656-4 2002 The ratios of V(max) for noradrenaline uptake and B(max) for nisoxetine binding (which are a measure of the turnover number of the transporter, i.e. the number of transport cycles per min) were greater for rNET and rR612Q than for hNET, rK7D, rE62K and rK375N. Norepinephrine 25-38 solute carrier family 6 member 2 Rattus norvegicus 206-210 11919656-5 2002 The K(m) of noradrenaline was lower for hNET, rK7D, rE62K and rK375N than for rNET or rR612Q. Norepinephrine 12-25 solute carrier family 6 member 2 Rattus norvegicus 78-82 11857564-1 2002 Norepinephrine (NE), a key neurotransmitter of the central and peripheral nervous systems, is synthesized by dopamine beta-hydroxylase (DBH) that catalyzes oxidation of dopamine (DA) to NE. Norepinephrine 0-14 dopamine beta-hydroxylase Homo sapiens 109-134 11857564-1 2002 Norepinephrine (NE), a key neurotransmitter of the central and peripheral nervous systems, is synthesized by dopamine beta-hydroxylase (DBH) that catalyzes oxidation of dopamine (DA) to NE. Norepinephrine 0-14 dopamine beta-hydroxylase Homo sapiens 136-139 11904129-1 2002 BACKGROUND: Plasma activity of dopamine beta-hydroxylase (DbetaH), the enzyme that converts dopamine to norepinephrine, is reportedly lower in patients with unipolar major depression with psychotic features (UDPF) than in those with nonpsychotic unipolar major depression (UD). Norepinephrine 104-118 dopamine beta-hydroxylase Homo sapiens 31-56 20332182-1 2010 Monoamine oxidase A (MAOA) and the transporters for serotonin (5-HTT) and norepinephrine (NET) may play important roles in regulating maternal monoamine neurotransmitters transferred across the placenta to the fetus. Norepinephrine 74-88 monoamine oxidase A Homo sapiens 0-19 11904129-1 2002 BACKGROUND: Plasma activity of dopamine beta-hydroxylase (DbetaH), the enzyme that converts dopamine to norepinephrine, is reportedly lower in patients with unipolar major depression with psychotic features (UDPF) than in those with nonpsychotic unipolar major depression (UD). Norepinephrine 104-118 dopamine beta-hydroxylase Homo sapiens 58-64 11904129-13 2002 In this regard, we hypothesize that abnormal regulation of hypothalamic-pituitary-adrenal function in UDPF lowers expression of DbetaH protein, which could in turn alter the ratio of dopamine and norepinephrine in noradrenergic neurons, thereby promoting development of psychotic symptoms. Norepinephrine 196-210 dopamine beta-hydroxylase Homo sapiens 128-134 11904130-2 2002 Dopamine beta-hydroxylase (DbetaH) catalyses the key step in biosynthesis of the neurotransmitter noradrenaline from dopamine, and low DbetaH activity is a possible risk factor for developing psychotic depression. Norepinephrine 98-111 dopamine beta-hydroxylase Homo sapiens 0-25 11854096-2 2002 In this study, the accumulation of AA-NAT mRNA induced by norepinephrine (NE) and peptides of the secretin superfamily (pituitary adenylate cyclase activating polypeptide (PACAP), vasoactive intestinal peptide (VIP), growth hormone releasing factor (GRF), secretin) was investigated by a new quantitative reverse transcription-PCR (RT-PCR) assay. Norepinephrine 58-72 aralkylamine N-acetyltransferase Rattus norvegicus 35-41 11805223-9 2002 Norepinephrine release promoted by ATP was also potentiated by the nucleotidase inhibitor 6-N,N-diethyl-beta-gamma-dibromomethylene-D-adenosine-5"-triphosphate (ARL67156) (30 microM) and blocked by a recombinant, soluble form of human E-NTPDase1 (solCD39). Norepinephrine 0-14 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 235-245 11752397-0 2002 Decreased intracellular calcium mediates the histamine H3-receptor-induced attenuation of norepinephrine exocytosis from cardiac sympathetic nerve endings. Norepinephrine 90-104 histamine receptor H3 Homo sapiens 45-66 11752397-1 2002 Activation of presynatic histamine H(3) receptors (H(3)R) down-regulates norepinephrine exocytosis from cardiac sympathetic nerve terminals, in both normal and ischemic conditions. Norepinephrine 73-87 histamine receptor H3 Homo sapiens 14-57 20332182-1 2010 Monoamine oxidase A (MAOA) and the transporters for serotonin (5-HTT) and norepinephrine (NET) may play important roles in regulating maternal monoamine neurotransmitters transferred across the placenta to the fetus. Norepinephrine 74-88 monoamine oxidase A Homo sapiens 21-25 20351116-7 2010 At 4 weeks post-MI, plasma levels of both norepinephrine and epinephrine were reduced in PNMT-driven GRK2 KO, compared with control mice, suggesting markedly reduced post-MI sympathetic activation. Norepinephrine 42-56 G protein-coupled receptor kinase 2 Mus musculus 101-105 11742803-2 2002 Quiescent brown preadipocytes express high levels of UCP-1 mRNA in response to triiodothyronine (T3) and norepinephrine (NE). Norepinephrine 105-119 uncoupling protein 1 Homo sapiens 53-58 11903811-0 2002 Noradrenaline and dopamine regulation of prolactin secretion in sheep: role in prolactin homeostasis but not photoperiodism. Norepinephrine 0-13 prolactin Ovis aries 79-88 19941049-2 2010 COMT and MAOA each contribute to the enzymatic degradation of dopamine and noradrenaline. Norepinephrine 75-88 monoamine oxidase A Homo sapiens 9-13 20193660-0 2010 Pontine norepinephrine defects in Mecp2-null mice involve deficient expression of dopamine beta-hydroxylase but not a loss of catecholaminergic neurons. Norepinephrine 8-22 methyl CpG binding protein 2 Mus musculus 34-39 20525314-6 2010 With synovial cell-culture experiments and ELISA, effects of norepinephrine, TNF, and cortisol on HNP1-3 were detected. Norepinephrine 61-75 HNP1 Homo sapiens 98-104 20525314-10 2010 Norepinephrine dose-dependently decreased HNP1-3 levels from RA and OA cells. Norepinephrine 0-14 HNP1 Homo sapiens 42-48 20525314-14 2010 CONCLUSIONS: This study demonstrated an inhibitory effect of norepinephrine on HNP1-3 of mixed synovial cells. Norepinephrine 61-75 HNP1 Homo sapiens 79-85 20525314-15 2010 In light of these findings, the loss of sympathetic nerve fibers with low resting norepinephrine levels might also augment the inflammatory process through HNP1-3. Norepinephrine 82-96 HNP1 Homo sapiens 156-162 20009769-1 2010 RATIONALE: Dopamine beta-hydroxylase (DBH) plays an essential role in catecholamine synthesis by converting dopamine into norepinephrine. Norepinephrine 122-136 dopamine beta-hydroxylase Homo sapiens 11-36 11903811-1 2002 The role of noradrenaline (NA) and dopamine (DA) in the hypothalamic control of prolactin (PRL) secretion was investigated in hypothalamic intact (control) and hypothalamo-pituitary disconnected (HPD) Soay rams. Norepinephrine 12-25 prolactin Ovis aries 80-89 11823070-8 2002 The mechanism by which chronic substance P receptor antagonist or conventional antidepressant treatment influences the pattern of firing activity of norepinephrine neurones remains to be elucidated. Norepinephrine 149-163 tachykinin receptor 1 Homo sapiens 31-51 20009769-1 2010 RATIONALE: Dopamine beta-hydroxylase (DBH) plays an essential role in catecholamine synthesis by converting dopamine into norepinephrine. Norepinephrine 122-136 dopamine beta-hydroxylase Homo sapiens 38-41 19912474-1 2010 The prolactin-releasing peptide (PrRP) has been proposed to be a co-transmitter or modulator of noradrenaline (NA) because it colocalises with NA in the A1 (in the ventrolateral reticular formation) and A2 (in the nucleus of the solitary tract; NTS) cell groups in the caudal medulla. Norepinephrine 96-109 prolactin releasing hormone Rattus norvegicus 4-31 19912474-1 2010 The prolactin-releasing peptide (PrRP) has been proposed to be a co-transmitter or modulator of noradrenaline (NA) because it colocalises with NA in the A1 (in the ventrolateral reticular formation) and A2 (in the nucleus of the solitary tract; NTS) cell groups in the caudal medulla. Norepinephrine 96-109 prolactin releasing hormone Rattus norvegicus 33-37 19295483-8 2009 The norepinephrine dose and plasma concentrations of soluble endothelial leukocyte adhesion molecule 1 and soluble intercellular adhesion molecule 1 significantly (P < 0.05) decreased in the PMX greater-than-2-h (prolonged) group than in the PMX 2-h (conventional) group (-17.8 +/- 14.6 vs. -1.8 +/- 2.7 microg/min, -143.0 +/- 111.0 vs. 0 +/- 2.8 ng/mL, and -126.2 +/- 144.9 vs. 16.5 +/- 108.1 ng/mL, respectively). Norepinephrine 4-18 selectin E Homo sapiens 61-102 12448081-8 2002 The co-localization of GAL and dopamine beta-hydroxylase (D beta H--a key enzyme of the noradrenaline synthesis pathway) in perivascular nerve fibers could lead to considerable vasospasms in the pancreas, resulting in deeper hypoxia of the organ. Norepinephrine 88-101 dopamine beta-hydroxylase Homo sapiens 31-56 11551920-2 2001 The alpha(1)-adrenergic agonist, norepinephrine (NE), enhances epidermal growth factor-stimulated DNA synthesis and inhibits activin A-induced growth inhibition, but the mechanisms of these actions are unclear. Norepinephrine 33-47 inhibin subunit beta A Rattus norvegicus 125-134 19615672-5 2009 Plasma MAOA dependent metabolites of norepinephrine: dihydroxyphenylglycol; dopamine: homovanillic and dihydroxyphenylacetic acid; and serotonin: 5-hydroxy-indol acetic acid were measured at the end of the second trimester, at delivery, and in arterial cord blood along with plasma cotinine. Norepinephrine 37-51 monoamine oxidase A Homo sapiens 7-11 19482560-1 2009 In this study we investigated the changes in norepinephrine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) gene expression in the stellate ganglia of naive controls and long-term socially isolated (12 weeks) adult rats and the response of these animals to additional immobilization stress. Norepinephrine 45-59 dopamine beta-hydroxylase Rattus norvegicus 108-133 19482560-1 2009 In this study we investigated the changes in norepinephrine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) gene expression in the stellate ganglia of naive controls and long-term socially isolated (12 weeks) adult rats and the response of these animals to additional immobilization stress. Norepinephrine 45-59 dopamine beta-hydroxylase Rattus norvegicus 135-138 19560519-2 2009 Dopamine-beta-hydroxylase (DBH) is the enzyme responsible for conversion of dopamine to norepinephrine, and thus plays an important role in controlling dispositions of these neurotransmitters. Norepinephrine 88-102 dopamine beta-hydroxylase Homo sapiens 0-25 11571937-2 2001 The brain"s ability to mobilize this so-called stress response is paralleled by activation of corticotropin-releasing hormone (CRH) in several nuclei, including the hypothalamus, amygdala and locus ceruleus, and stimulation of the locus ceruleus norepinephrine (LC/NE) system in the brain stem. Norepinephrine 246-260 corticotropin releasing hormone Homo sapiens 94-125 11571937-2 2001 The brain"s ability to mobilize this so-called stress response is paralleled by activation of corticotropin-releasing hormone (CRH) in several nuclei, including the hypothalamus, amygdala and locus ceruleus, and stimulation of the locus ceruleus norepinephrine (LC/NE) system in the brain stem. Norepinephrine 246-260 corticotropin releasing hormone Homo sapiens 127-130 19560519-2 2009 Dopamine-beta-hydroxylase (DBH) is the enzyme responsible for conversion of dopamine to norepinephrine, and thus plays an important role in controlling dispositions of these neurotransmitters. Norepinephrine 88-102 dopamine beta-hydroxylase Homo sapiens 27-30 19553916-7 2009 Taken together these studies show that VEGF is necessary for the behavioral effects of the SSRI fluoxetine, as well as norepinephrine selective reuptake inhibitor, and that these effects may be mediated by 5-HT1A receptors located on neurons and endothelial cells. Norepinephrine 119-133 vascular endothelial growth factor A Rattus norvegicus 39-43 19470703-2 2009 Here we report Sik1 expression was induced by norepinephrine (NE) in rat pinealocytes primarily through activation of beta-adrenergic receptors, with a minor contribution from activation of alpha-adrenergic receptors. Norepinephrine 46-60 salt-inducible kinase 1 Rattus norvegicus 15-19 18958498-3 2009 Because cyclic adenosine 3",5"-monophosphate stimulates the dopamine beta hydroxylase gene, an activating mutation of the Gsalpha protein may cause the hyperproduction of norepinephrine via dopamine. Norepinephrine 171-185 dopamine beta-hydroxylase Homo sapiens 60-85 19362092-8 2009 Soluble guanylyl cyclase (sGC) inhibition caused a greater increase of evoked norepinephrine release in the l-arginine fed SHR compared with the non-fed SHR. Norepinephrine 78-92 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 0-24 19362092-8 2009 Soluble guanylyl cyclase (sGC) inhibition caused a greater increase of evoked norepinephrine release in the l-arginine fed SHR compared with the non-fed SHR. Norepinephrine 78-92 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 26-29 19194374-10 2009 Monoamines such as noradrenalin and serotonin may modulate these relationships, given that their metabolism varies according to MAOA variants, and that they modulate both emotional brain systems and antisocial aggression. Norepinephrine 19-31 monoamine oxidase A Homo sapiens 128-132 11798029-8 2001 Nucleotides maintain the proton conductance inhibited while fatty acids act as cytosolic second messengers of noradrenaline to active UCP1. Norepinephrine 110-123 uncoupling protein 1 Homo sapiens 134-138 11406127-4 2001 The level of norepinephrine in the spinal cord of beta3-/- mice was 44% less than that of beta3+/+ mice, and did not differ in the brainstem, cortex or striatum. Norepinephrine 13-27 gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 Mus musculus 50-55 19223155-7 2009 According to our results, the higher serotonergic symptom score and cord blood DHPG concentration in rapid MAO-A metabolizers suggest that norepinephrine may modify the severity of perinatal serotonergic symptoms. Norepinephrine 139-153 monoamine oxidase A Homo sapiens 107-112 11394305-0 2001 A method for the measurement of catechol-O-methyltransferase activity using norepinephrine, an endogenous substrate. Norepinephrine 76-90 catechol-O-methyltransferase Rattus norvegicus 32-60 11394305-1 2001 We propose a highly sensitive method for the measurement of catechol-O-methyltransferase (COMT) activity with norepinephrine (NE), an endogenous native substrate. Norepinephrine 110-124 catechol-O-methyltransferase Rattus norvegicus 60-88 11394305-1 2001 We propose a highly sensitive method for the measurement of catechol-O-methyltransferase (COMT) activity with norepinephrine (NE), an endogenous native substrate. Norepinephrine 110-124 catechol-O-methyltransferase Rattus norvegicus 90-94 11316770-2 2001 Stress activates A1/A2 noradrenergic neurons, and then noradrenaline (NA) stimulates ACTH secretion through hypothalamic CRH. Norepinephrine 55-68 corticotropin releasing hormone Homo sapiens 121-124 19356247-4 2009 NET function in adult noradrenergic neurons of the peripheral and central nervous systems is to internalize norepinephrine from the synaptic cleft. Norepinephrine 108-122 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 0-3 11264228-6 2001 Inhibition of noradrenaline-induced contractions by DXR was attenuated by superoxide dismutase, and alpha(1A)-adrenoceptor protein expression recovered. Norepinephrine 14-27 alpha-1A adrenergic receptor Oryctolagus cuniculus 100-122 11264228-13 2001 These results suggest that 0.3 microM DXR selectively down-regulates the alpha(1A)-adrenoceptor protein expression, resulting in a decrease in the noradrenaline-induced contraction. Norepinephrine 147-160 alpha-1A adrenergic receptor Oryctolagus cuniculus 73-95 19326052-6 2009 Finally, confounding variables on dPP measurements, such as ventilation parameters, pneumoperitoneum and use of norepinephrine are also mentioned. Norepinephrine 112-126 decapentaplegic Drosophila melanogaster 34-37 19046799-2 2009 The aim of this study was to relate psychiatric distress, as expressed by the scores in the SCL-90 subscales, to CSF levels of the main metabolites of noradrenaline (MHPG), serotonin (5-HIAA), and dopamine (HVA) in NPH patients. Norepinephrine 151-164 colony stimulating factor 2 Homo sapiens 113-116 11306460-6 2001 In summary, norepinephrine-induced locomotion of SW 480 cells is beta2-adrenoceptor mediated and distinct from spontaneous locomotion concerning the PTK involvement. Norepinephrine 12-26 protein tyrosine kinase 2 beta Homo sapiens 149-152 11264717-3 2001 In vitro studies showed that mPer1 mRNA and mPER1 protein in mouse pineal gland are induced following the activation of a signalling pathway of fundamental importance for pineal physiology, the norepinephrine/cAMP/phosphoCREB cascade. Norepinephrine 194-208 period circadian clock 1 Mus musculus 29-34 11264717-3 2001 In vitro studies showed that mPer1 mRNA and mPER1 protein in mouse pineal gland are induced following the activation of a signalling pathway of fundamental importance for pineal physiology, the norepinephrine/cAMP/phosphoCREB cascade. Norepinephrine 194-208 period circadian clock 1 Mus musculus 44-49 11181015-1 2001 An impairment of norepinephrine (NE) re-uptake by the neuronal NE transporter (NET) has been shown to contribute to the increased cardiac net-release of NE in congestive heart failure (CHF). Norepinephrine 17-31 solute carrier family 6 member 2 Rattus norvegicus 63-77 11181015-1 2001 An impairment of norepinephrine (NE) re-uptake by the neuronal NE transporter (NET) has been shown to contribute to the increased cardiac net-release of NE in congestive heart failure (CHF). Norepinephrine 17-31 solute carrier family 6 member 2 Rattus norvegicus 79-82 11181015-1 2001 An impairment of norepinephrine (NE) re-uptake by the neuronal NE transporter (NET) has been shown to contribute to the increased cardiac net-release of NE in congestive heart failure (CHF). Norepinephrine 17-31 solute carrier family 6 member 2 Rattus norvegicus 138-141 11321513-10 2001 The postprandial rise in plasma leptin was accompanied by a marked increment in gut hormones; gastrin, CCK and PP and stress hormones such as norepinephrine, cortisol and GH. Norepinephrine 142-156 leptin Homo sapiens 32-38 28095225-3 2001 administration of noradrenaline were markedly enhanced in eNOS knockout mice. Norepinephrine 18-31 nitric oxide synthase 3, endothelial cell Mus musculus 58-62 11239021-0 2001 Erythropoietin modulates angiotensin II- or noradrenaline-induced Ca(2+) mobilization in cultured rat vascular smooth-muscle cells. Norepinephrine 44-57 erythropoietin Rattus norvegicus 0-14 11170900-1 2001 Dopamine-beta-hydroxylase (D beta H) catalyzes the conversion of dopamine to norepinephrine and is released from sympathetic neurons into the circulation. Norepinephrine 77-91 dopamine beta-hydroxylase Homo sapiens 0-25 19076268-9 2009 These studies provide the first direct evidence for functional, nongenomic actions of TH leading to rapid changes in neuronal excitability in adult rat DG studied in vivo and highlight the opposing effects of T4 and T3 on norepinephrine-induced responses of CA1 cells studied in vitro. Norepinephrine 222-236 carbonic anhydrase 1 Rattus norvegicus 258-261 11160591-5 2001 Anemia (by causing hypoxia) and iron deficiency (by increasing serum norepinephrine concentrations) can induce maternal and fetal stress, which stimulates the synthesis of corticotropin-releasing hormone (CRH). Norepinephrine 69-83 corticotropin releasing hormone Homo sapiens 172-203 11160591-5 2001 Anemia (by causing hypoxia) and iron deficiency (by increasing serum norepinephrine concentrations) can induce maternal and fetal stress, which stimulates the synthesis of corticotropin-releasing hormone (CRH). Norepinephrine 69-83 corticotropin releasing hormone Homo sapiens 205-208 11120594-2 2000 In the present study, we show that norepinephrine and terbutaline stimulate the beta2AR to decrease the level of IL-2 produced by freshly isolated murine splenic naive CD4+ T cells from either Balb/C or DO11.10 transgenic mice and activated polyclonally with anti-CD3 and anti-CD28 mAbs. Norepinephrine 35-49 adrenergic receptor, beta 2 Mus musculus 80-87 11120594-2 2000 In the present study, we show that norepinephrine and terbutaline stimulate the beta2AR to decrease the level of IL-2 produced by freshly isolated murine splenic naive CD4+ T cells from either Balb/C or DO11.10 transgenic mice and activated polyclonally with anti-CD3 and anti-CD28 mAbs. Norepinephrine 35-49 interleukin 2 Mus musculus 113-117 10921912-3 2000 The activatory effects of norepinephrine and retinoic acid (RA) on rodent ucp1 gene transcription have been well characterized. Norepinephrine 26-40 uncoupling protein 1 Homo sapiens 74-78 11003990-4 2000 When PBMC were stimulated with 10(-8)M norepinephrine in vitro, the expression of these adhesion molecules on CD3(-)CD56(+) NK cells was downmodulated within 30 min. Norepinephrine 39-53 neural cell adhesion molecule 1 Homo sapiens 116-120 19129402-0 2009 Astrocyte-derived MCP-1 mediates neuroprotective effects of noradrenaline. Norepinephrine 60-73 C-C motif chemokine ligand 2 Homo sapiens 18-23 21274292-0 2009 The relationship between leptin and norepinephrine levels during OGTT in normotensive and hypertensive obese adolescents. Norepinephrine 36-50 leptin Homo sapiens 25-31 21274292-3 2009 Our study is designed to explore the relationship between leptin and norepinephrine levels in pediatric patients and to identify any contributors to hypertension for this population. Norepinephrine 69-83 leptin Homo sapiens 58-64 19343315-9 2009 Conversely, the inhibition of endogeneous miR-338 levels in the axon significantly increased mitochondrial activity and norepinephrine uptake into the axon. Norepinephrine 120-134 microRNA 338 Homo sapiens 42-49 10998646-10 2000 Co-incubation of P. aeruginosa with norepinephrine increased PA-I expression in vitro, suggesting that norepinephrine plays a role in the observed response in vivo. Norepinephrine 36-50 serine (or cysteine) peptidase inhibitor, clade E, member 1 Mus musculus 61-65 10998646-10 2000 Co-incubation of P. aeruginosa with norepinephrine increased PA-I expression in vitro, suggesting that norepinephrine plays a role in the observed response in vivo. Norepinephrine 103-117 serine (or cysteine) peptidase inhibitor, clade E, member 1 Mus musculus 61-65 10991930-5 2000 Nociceptin produced a concentration-dependent inhibition of the adrenergic motor response to electrical-field stimulation (EC(50) 19 nM, pEC(50) 7.7+/-0.1, n=8), but the response to exogenous noradrenaline (0.2 - 1 microM) was unaffected. Norepinephrine 192-205 prepronociceptin Rattus norvegicus 0-10 18768761-6 2008 Furthermore, norepinephrine and forskolin were able to synchronize circadian rhythms in bmal1. Norepinephrine 13-27 aryl hydrocarbon receptor nuclear translocator-like Mus musculus 88-93 18638525-0 2008 Distinct regulation of brain-derived neurotrophic factor and noradrenaline in S100B knockout mice. Norepinephrine 61-74 S100 protein, beta polypeptide, neural Mus musculus 78-83 10952676-2 2000 Human U-II was a potent vasoconstrictor of endothelium-intact isolated rat thoracic aorta (EC(50)=3.5+/-1.1 nM, R(max)=103+/-10% of control contraction induced by 60 mM KCl and 1 microM noradrenaline). Norepinephrine 186-199 urotensin 2 Homo sapiens 6-10 18437281-1 2008 Monoamine oxidase A (MAOA) abnormality has been suggested as a crucial factor in the pathogenesis of mood disorder, because MAOA is associated with the metabolism of monoamines such as serotonin and norepinephrine. Norepinephrine 199-213 monoamine oxidase A Homo sapiens 0-19 10887204-1 2000 Dopamine-beta-hydroxylase (DbetaH) is a copper-containing enzyme that uses molecular oxygen and ascorbate to catalyze the addition of a hydroxyl group on the beta-carbon of dopamine to form norepinephrine. Norepinephrine 190-204 dopamine beta-hydroxylase Homo sapiens 0-25 10887204-1 2000 Dopamine-beta-hydroxylase (DbetaH) is a copper-containing enzyme that uses molecular oxygen and ascorbate to catalyze the addition of a hydroxyl group on the beta-carbon of dopamine to form norepinephrine. Norepinephrine 190-204 dopamine beta-hydroxylase Homo sapiens 27-33 10848638-3 2000 Plasma noradrenaline was gradually suppressed (P < 0.05) by 62 +/- 8 and 104 +/- 11 pg mL-1 during xiphoid and neck immersion, respectively, indicating a graded suppression of sympathetic nervous activity. Norepinephrine 7-20 L1 cell adhesion molecule Mus musculus 90-94 10981165-3 2000 Intravenous leptin increases norepinephrine turnover and sympathetic nerve activity to thermogenic brown adipose tissue. Norepinephrine 29-43 leptin Homo sapiens 12-18 10942111-1 2000 Non-neuronal monoamine transporters OCT1, OCT2, and EMT, which are all members of the amphiphilic solute facilitator family, control signal transmission by removing released transmitters, such as dopamine, noradrenaline, adrenaline, 5-hydroxytryptamine, and histamine, from the extracellular space. Norepinephrine 206-219 solute carrier family 22 member 2 Homo sapiens 42-46 10942111-1 2000 Non-neuronal monoamine transporters OCT1, OCT2, and EMT, which are all members of the amphiphilic solute facilitator family, control signal transmission by removing released transmitters, such as dopamine, noradrenaline, adrenaline, 5-hydroxytryptamine, and histamine, from the extracellular space. Norepinephrine 206-219 IL2 inducible T cell kinase Homo sapiens 52-55 10997647-1 2000 OBJECTIVES: To determine the dependence of plasma leptin concentrations upon circulating noradrenaline (NA) and thyroid hormones (TH) in humans. Norepinephrine 89-102 leptin Homo sapiens 50-56 10718926-10 2000 In summary, these experiments suggest that adrenoceptors and not dopamine receptors are responsible for the inhibitory effect of noradrenaline on prolactin secretion in vitro but do not implicate a particular adrenoceptor subtype. Norepinephrine 129-142 prolactin Ovis aries 146-155 10685879-7 2000 Procaine also inhibited uptake of norepinephrine (NE) and serotonin (5-HT) by the norepinephrine transporter (NET) or serotonin transporter (SERT) expressed in COS cells. Norepinephrine 34-48 solute carrier family 6 member 2 Rattus norvegicus 82-108 10685879-7 2000 Procaine also inhibited uptake of norepinephrine (NE) and serotonin (5-HT) by the norepinephrine transporter (NET) or serotonin transporter (SERT) expressed in COS cells. Norepinephrine 34-48 solute carrier family 6 member 2 Rattus norvegicus 110-113 10647887-7 1999 The uVNTR genotype may be a common genetic determinant of significant individual differences in oxidizing capacity for critical MAO-A substrates, which include serotonin, norepinephrine, and tyramine. Norepinephrine 171-185 monoamine oxidase A Homo sapiens 128-133 10573542-1 1999 Dopamine beta-monooxygenase (DBM), a cuproenzyme, converts dopamine to norepinephrine in selected cells. Norepinephrine 71-85 dopamine beta-hydroxylase Rattus norvegicus 0-27 10573542-1 1999 Dopamine beta-monooxygenase (DBM), a cuproenzyme, converts dopamine to norepinephrine in selected cells. Norepinephrine 71-85 dopamine beta-hydroxylase Rattus norvegicus 29-32 10425201-6 1999 Murine recombinant leptin (>==50 nM) strongly induced the release of both epinephrine (E) and norepinephrine (NE) from chromaffin cells. Norepinephrine 97-111 leptin Mus musculus 19-25 10411589-3 1999 There were small but significant differences between the rat NET and the human or bovine NETs with respect to the affinities of sodium ions (greater for rat than for bovine) of the substrates norepinephrine, epinephrine, and 1-methyl-4-phenylpyridinium (greater for human than for rat), and of the inhibitor cocaine (greater for human and bovine than for rat), whereas the affinities of dopamine and of most inhibitors, including tricyclic antidepressants, showed no species differences. Norepinephrine 192-206 solute carrier family 6 member 2 Rattus norvegicus 61-64 10385422-0 1999 Fluctuating estrogen and progesterone receptor expression in brainstem norepinephrine neurons through the rat estrous cycle. Norepinephrine 71-85 progesterone receptor Rattus norvegicus 25-46 10215671-4 1999 alpha-Methylnoradrenaline dose-dependently increased heart rate, systolic blood pressure, cardiac output, blood glucose, serum insulin, free fatty acids, and gastrin, shortened the duration of heart rate-corrected electromechanical systole, and decreased diastolic blood pressure, total peripheral resistance, and plasma noradrenaline. Norepinephrine 12-25 gastrin Homo sapiens 158-165 18437281-1 2008 Monoamine oxidase A (MAOA) abnormality has been suggested as a crucial factor in the pathogenesis of mood disorder, because MAOA is associated with the metabolism of monoamines such as serotonin and norepinephrine. Norepinephrine 199-213 monoamine oxidase A Homo sapiens 21-25 18437281-1 2008 Monoamine oxidase A (MAOA) abnormality has been suggested as a crucial factor in the pathogenesis of mood disorder, because MAOA is associated with the metabolism of monoamines such as serotonin and norepinephrine. Norepinephrine 199-213 monoamine oxidase A Homo sapiens 124-128 18338249-3 2008 GATA-3 robustly transactivates the promoter function of the noradrenaline (NA)-synthesizing DBH gene, via two specific upstream promoter domains; one at -62 to -32 bp and the other at -891 to -853 bp. Norepinephrine 60-73 dopamine beta-hydroxylase Homo sapiens 92-95 18173840-3 2008 Dopamine-beta hydroxylase (DbH) catalyzes the conversion of dopamine to norepinephrine and could, therefore, have an influence on both cocaine action and the basal sensitivity of neurotransmitter systems to cocaine. Norepinephrine 72-86 dopamine beta-hydroxylase Homo sapiens 0-25 18173840-3 2008 Dopamine-beta hydroxylase (DbH) catalyzes the conversion of dopamine to norepinephrine and could, therefore, have an influence on both cocaine action and the basal sensitivity of neurotransmitter systems to cocaine. Norepinephrine 72-86 dopamine beta-hydroxylase Homo sapiens 27-30 17978496-4 2007 COMT activities were assessed by measuring normetanephrine with the use of norepinephrine as an endogenous substrate. Norepinephrine 75-89 catechol-O-methyltransferase Rattus norvegicus 0-4 17868372-6 2007 Dopamine beta hydroxylase staining was used to confirm N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine-depleted terminal norepinephrine levels. Norepinephrine 118-132 dopamine beta-hydroxylase Rattus norvegicus 0-25 18396760-0 2007 [The influence of terbutaline on VEGF gene expression in rat astrocytes after norepinephrine and burn serum induction]. Norepinephrine 78-92 vascular endothelial growth factor A Rattus norvegicus 33-37 18396760-1 2007 OBJECTIVE: To investigate the influence of adrenoreceptor beta-agonists terbutaline on gene expression of vascular endothelial growth factor (VEGF) in rat astrocyte after induction by norepinephrine (NE) and burn serum. Norepinephrine 184-198 vascular endothelial growth factor A Rattus norvegicus 106-140 18396760-1 2007 OBJECTIVE: To investigate the influence of adrenoreceptor beta-agonists terbutaline on gene expression of vascular endothelial growth factor (VEGF) in rat astrocyte after induction by norepinephrine (NE) and burn serum. Norepinephrine 184-198 vascular endothelial growth factor A Rattus norvegicus 142-146 17923045-16 2007 CONCLUSION: Sustained caused increased tone of sympathetic, heterogeneous accumulation of noradrenaline and down regulation of beta1 receptor, which was mediated by NGF. Norepinephrine 90-103 nerve growth factor Canis lupus familiaris 165-168 17625104-2 2007 Norepinephrine is synthesized from dopamine by dopamine-beta-hydroxylase (DBH). Norepinephrine 0-14 dopamine beta-hydroxylase Homo sapiens 47-72 17625104-2 2007 Norepinephrine is synthesized from dopamine by dopamine-beta-hydroxylase (DBH). Norepinephrine 0-14 dopamine beta-hydroxylase Homo sapiens 74-77 17625104-9 2007 High DBH in POTS was linked to elevated plasma levels of norepinephrine. Norepinephrine 57-71 dopamine beta-hydroxylase Homo sapiens 5-8 17394554-0 2007 Noradrenaline enhances the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of PI3K/Akt and the mTOR/S6K pathway. Norepinephrine 0-13 solute carrier family 16 member 7 Homo sapiens 82-86 17394554-1 2007 Monocarboxylate transporter 2 (MCT2) expression is up-regulated by noradrenaline (NA) in cultured cortical neurons via a putative but undetermined translational mechanism. Norepinephrine 67-80 solute carrier family 16 member 7 Homo sapiens 0-29 17394554-1 2007 Monocarboxylate transporter 2 (MCT2) expression is up-regulated by noradrenaline (NA) in cultured cortical neurons via a putative but undetermined translational mechanism. Norepinephrine 67-80 solute carrier family 16 member 7 Homo sapiens 31-35 17429342-0 2007 Modulation of angiotensin II and norepinephrine-induced plasminogen activator inhibitor-1 expression by AT1a receptor deficiency. Norepinephrine 33-47 serine (or cysteine) peptidase inhibitor, clade E, member 1 Mus musculus 56-89 17429342-8 2007 Norepinephrine increased PAI-1 expression in WT heart and aorta, and in AT(1a)-/- heart, kidney, and liver with no effect of losartan. Norepinephrine 0-14 serine (or cysteine) peptidase inhibitor, clade E, member 1 Mus musculus 25-30 17429342-11 2007 Further, norepinephrine induces PAI-1 expression in vivo with AT(1a) receptor deficiency modulating the effect. Norepinephrine 9-23 serine (or cysteine) peptidase inhibitor, clade E, member 1 Mus musculus 32-37 17448453-1 2007 OBJECTIVE: Phenylethanolamine-N-methyltransferase (PNMT), the enzyme that synthesizes epinephrine (EPI) from norepinephrine (NE) in the adrenal gland, is present in extra-adrenal tissues including heart. Norepinephrine 109-123 phenylethanolamine N-methyltransferase Oryctolagus cuniculus 11-49 17585061-2 2007 The monoamine oxidase-A (MAOA) gene, which plays a vital role in degradation of neurotransmitters such as serotonin, norepinephrine, and dopamine, contains a polymorphism in its promoter region (MAOA-uVNTR) that affects transcriptional efficiency. Norepinephrine 117-131 monoamine oxidase A Homo sapiens 4-23 10068346-2 1999 In vitro application of noradrenaline stimulates expression of cytoskeletal filaments, particularly actin and myosin, by prostatic stromal cells, thus enhancing their differentiation towards smooth muscle cells. Norepinephrine 24-37 myosin heavy chain 14 Homo sapiens 110-116 9933594-8 1999 Inhibition of Cdk5 with olomoucine decreased evoked norepinephrine secretion from chromaffin cells, an effect not observed with the inactive analogue iso-olomoucine. Norepinephrine 52-66 cyclin dependent kinase 5 Homo sapiens 14-18 9930750-2 1999 A quantitative double-label in situ hybridization technique was used to examine CNS GTPCH mRNA expression within serotonin, dopamine, and norepinephrine neurons of male and female wild-type and hph-1 mice. Norepinephrine 138-152 GTP cyclohydrolase 1 Mus musculus 84-89 9917358-0 1999 The neurotransmitter noradrenaline drives noggin-expressing ectoderm cells to activate N-tubulin and become neurons. Norepinephrine 21-34 tubulin beta 2B class IIb S homeolog Xenopus laevis 87-96 9917358-6 1999 By contrast, 10(-8) M noradrenaline activated N-tubulin in ectoderm caps expressing the neural inducing molecule noggin by the time intact siblings had become mid-neurulae. Norepinephrine 22-35 tubulin beta 2B class IIb S homeolog Xenopus laevis 46-55 9917358-8 1999 The alpha-adrenergic receptor blocker prazosin inhibited both noradrenaline- and methoxamine-induced activation of N-tubulin. Norepinephrine 62-75 tubulin beta 2B class IIb S homeolog Xenopus laevis 115-124 9917358-13 1999 We propose that noradrenaline is an important endogenous modulator of neuronal fate, driving noggin-expressing cells to become neurons by binding to alpha-adrenergic receptors and activating a cascade that culminates in the expression of the neuronal markers N-tubulin and 3A10. Norepinephrine 16-29 tubulin beta 2B class IIb S homeolog Xenopus laevis 259-268 10073744-1 1999 AIMS: Neuropeptide Y (NPY) is a sympathetic neurotransmitter released with noradrenaline during sympathetic stimulation. Norepinephrine 75-88 neuropeptide Y Homo sapiens 6-20 10073744-1 1999 AIMS: Neuropeptide Y (NPY) is a sympathetic neurotransmitter released with noradrenaline during sympathetic stimulation. Norepinephrine 75-88 neuropeptide Y Homo sapiens 22-25 9788975-0 1998 Inhibition of norepinephrine-induced cardiac hypertrophy in s100beta transgenic mice. Norepinephrine 14-28 S100 protein, beta polypeptide, neural Mus musculus 60-68 9760026-8 1998 The angiotensin AT1 receptor antagonist elicited a fall in plasma noradrenaline values after a 1 Hz stimulation and abolished the increase in plasma noradrenaline levels induced by the 10 (but not 20) Hz stimulation. Norepinephrine 66-79 angiotensin II receptor type 1 Canis lupus familiaris 16-19 9760026-8 1998 The angiotensin AT1 receptor antagonist elicited a fall in plasma noradrenaline values after a 1 Hz stimulation and abolished the increase in plasma noradrenaline levels induced by the 10 (but not 20) Hz stimulation. Norepinephrine 149-162 angiotensin II receptor type 1 Canis lupus familiaris 16-19 9619531-2 1998 It has been speculated that the neurotransmitter norepinephrine (NE) (noradrenaline), possibly via the sympathetic nervous system, may represent the afferent signal which modulates leptin release from adipocytes. Norepinephrine 49-63 leptin Homo sapiens 181-187 9619531-2 1998 It has been speculated that the neurotransmitter norepinephrine (NE) (noradrenaline), possibly via the sympathetic nervous system, may represent the afferent signal which modulates leptin release from adipocytes. Norepinephrine 70-83 leptin Homo sapiens 181-187 9535946-7 1998 Similarly, norepinephrine depressed excitatory synaptic transmission in the NAc by an alpha-adrenergic receptor-dependent mechanism but was without effect on excitatory transmission in the dorsal striatum. Norepinephrine 11-25 synuclein alpha Homo sapiens 76-79 9568844-7 1998 RESULTS: In kidneys preconstricted by noradrenaline (NA 1.5 x 10(-7) mol/l) VEGF/VPF (155 pmol/l) caused an almost complete return of renal perfusion flow rate to pre-NA values (before NA 113 +/- 4%, after NA 100%, 15 min with VEGF/VPF 111 +/- 4%). Norepinephrine 38-51 vascular endothelial growth factor A Rattus norvegicus 76-84 9475874-4 1998 When administered in the presence of norepinephrine, 10(-8) and 10(-7) M NPY (n = 6) produced extreme increases in Ppa to 66.1 +/- 20.5 and 114.7 +/- 25.5 mmHg, respectively, that were due primarily to an increased arterial resistance. Norepinephrine 37-51 neuropeptide Y Oryctolagus cuniculus 73-76 9608607-0 1998 Mechanism of triazolo-benzodiazepine and benzodiazepine action in anxiety and depression: behavioral studies with concomitant in vivo CA1 hippocampal norepinephrine and serotonin release detection in the behaving animal. Norepinephrine 150-164 carbonic anhydrase 1 Rattus norvegicus 134-137 9458879-1 1998 Neuropeptide Y (NPY) is a vasoconstrictor peptide and a cotransmitter with norepinephrine (NE) in sympathetic nerve terminals and is thought to be involved in sympathetic nerve stimulation (SNS)-induced vasoconstriction. Norepinephrine 75-89 neuropeptide Y Homo sapiens 0-14 9458879-1 1998 Neuropeptide Y (NPY) is a vasoconstrictor peptide and a cotransmitter with norepinephrine (NE) in sympathetic nerve terminals and is thought to be involved in sympathetic nerve stimulation (SNS)-induced vasoconstriction. Norepinephrine 75-89 neuropeptide Y Homo sapiens 16-19 9597749-3 1998 Norepinephrine, released from sympathetic terminals and acting via beta-adrenoceptors and cAMP, is the main positive regulator of both UCP synthesis and activity. Norepinephrine 0-14 uncoupling protein 1 Homo sapiens 135-138 9786171-8 1998 Blockade experiments showed that the vasomotor responses to norepinephrine were blocked by prazosin, to NPY by BIBP 3226, acetylcholine by atropin, substance P by RP 67580, and the human alpha-CGRP response by human alpha-CGRP(8-37). Norepinephrine 60-74 neuropeptide Y Homo sapiens 104-107 9452885-3 1997 Cell extracts from epidermal suction blister roofs revealed only half the normal activity of phenylethanolamine-N-methyl transferase (PNMT) together with a threefold induction of the norepinephrine-degrading enzyme monoamine oxidase A (MAO-A). Norepinephrine 183-197 monoamine oxidase A Homo sapiens 215-234 17585061-2 2007 The monoamine oxidase-A (MAOA) gene, which plays a vital role in degradation of neurotransmitters such as serotonin, norepinephrine, and dopamine, contains a polymorphism in its promoter region (MAOA-uVNTR) that affects transcriptional efficiency. Norepinephrine 117-131 monoamine oxidase A Homo sapiens 25-29 17585061-2 2007 The monoamine oxidase-A (MAOA) gene, which plays a vital role in degradation of neurotransmitters such as serotonin, norepinephrine, and dopamine, contains a polymorphism in its promoter region (MAOA-uVNTR) that affects transcriptional efficiency. Norepinephrine 117-131 monoamine oxidase A Homo sapiens 195-199 17303090-2 2007 The control of GnRH secretion depends on several neurotransmitters, such as serotonin (5-HT), noradrenaline (NA), dopamine (DA) and nitric oxide (NO). Norepinephrine 94-107 gonadotropin releasing hormone 1 Rattus norvegicus 15-19 17334639-6 2007 Investigations carried out in the rat show that galanin is also able to directly stimulate corticosterone (glucocorticoid) secretion from adrenocortical cells, through GAL-R1 and GAL-R2 coupled to the adenylate cyclase-protein kinase A signaling cascade, and nor-epinephrine release from adrenal medulla. Norepinephrine 259-274 galanin receptor 1 Rattus norvegicus 168-185 17318500-0 2007 The effects of both noradrenaline and CGP12177, mediated through human beta1 -adrenoceptors, are reduced by PDE3 in human atrium but PDE4 in CHO cells. Norepinephrine 20-33 phosphodiesterase 4D, cAMP-specific-like 1 Rattus norvegicus 108-112 17318500-9 2007 PDE3, but not PDE4, blunts the positive inotropic effects of both (-)-noradrenaline and (-)-CGP12177 through H and L sites, respectively, of human atrial beta1 -adrenoceptors. Norepinephrine 66-83 phosphodiesterase 4D, cAMP-specific-like 1 Rattus norvegicus 0-4 17079074-4 2007 In contrast, treatment with proteasome inhibitors increased norepinephrine-stimulated MKP-1 protein levels and abolished the decline in norepinephrine-stimulated MKP-1 protein levels caused by inhibition of transcription or translation, or blockade of alpha-adrenergic receptors. Norepinephrine 60-74 dual specificity phosphatase 1 Rattus norvegicus 86-91 17079074-4 2007 In contrast, treatment with proteasome inhibitors increased norepinephrine-stimulated MKP-1 protein levels and abolished the decline in norepinephrine-stimulated MKP-1 protein levels caused by inhibition of transcription or translation, or blockade of alpha-adrenergic receptors. Norepinephrine 136-150 dual specificity phosphatase 1 Rattus norvegicus 162-167 17074321-8 2007 Decreased expression of DBH with age in the retina could lead to reduced production of norepinephrine, potentially resulting in an increase of beta1-adrenergic receptor expression due to denervation supersensitivity. Norepinephrine 87-101 dopamine beta-hydroxylase Rattus norvegicus 24-27 17365979-1 2007 PURPOSE: To elucidate differential functional and phenotypic changes in response to relevant catecholamines, the generation of oxidative free radicals by PMN, and changes in the expression of L-selectin and Mac-1 on the surface of PMN were examined in the presence of epinephrine, norepinephrine and dopamine in physiological and pharmacological concentrations. Norepinephrine 281-295 selectin L Homo sapiens 192-202 9368819-14 1997 The difference in beta 3- and alpha 2-adrenoceptor function might explain why noradrenaline induced lipolysis is increased in the two visceral fat depots, as compared to the subcutaneous fat depot. Norepinephrine 78-91 adrenoceptor beta 3 Homo sapiens 18-50 9348548-4 1997 Substantial regional differences in the density and distribution of CRH-immunoreactive axons were found in the dopamine-, noradrenaline- and serotonin-containing cell body regions of the human brainstem. Norepinephrine 122-135 corticotropin releasing hormone Homo sapiens 68-71 9322991-6 1997 Intravenous leptin increases norepinephrine turnover and sympathetic nerve activity to thermogenic brown adipose tissue. Norepinephrine 29-43 leptin Homo sapiens 12-18 9213209-5 1997 NPY, its endogenous analog, peptide YY, and its C-terminal fragment, NPY13-36, but not its analog, [Leu31,Pro34]NPY, concentration dependently (1-100 nM) inhibited [3H]noradrenaline release in all tissues studied. Norepinephrine 168-181 neuropeptide Y Homo sapiens 0-3 17229089-2 2006 We thus tested in rats the effect of pharmacological depletion of noradrenaline with the noradrenergic toxin DSP4 (5 mg/kg) on the expression of the TJ proteins zonula occludens-1 (ZO1) and occludin. Norepinephrine 66-79 tight junction protein 1 Rattus norvegicus 161-179 9213209-5 1997 NPY, its endogenous analog, peptide YY, and its C-terminal fragment, NPY13-36, but not its analog, [Leu31,Pro34]NPY, concentration dependently (1-100 nM) inhibited [3H]noradrenaline release in all tissues studied. Norepinephrine 168-181 neuropeptide Y Homo sapiens 69-72 9213209-7 1997 We conclude that prejunctional inhibition of noradrenaline release in human heart and human and rabbit kidney occurs through NPY receptors of the Y2 subtype, which appear to couple to a pertussis toxin-sensitive G protein. Norepinephrine 45-58 neuropeptide Y Oryctolagus cuniculus 125-128 17229089-2 2006 We thus tested in rats the effect of pharmacological depletion of noradrenaline with the noradrenergic toxin DSP4 (5 mg/kg) on the expression of the TJ proteins zonula occludens-1 (ZO1) and occludin. Norepinephrine 66-79 tight junction protein 1 Rattus norvegicus 181-184 9126981-2 1997 The sympathetic neurotransmitter norepinephrine modulates the level of T and B lymphocyte activity by binding to the beta2-adrenergic receptor (beta2AR). Norepinephrine 33-47 adrenergic receptor, beta 2 Mus musculus 117-142 9126981-2 1997 The sympathetic neurotransmitter norepinephrine modulates the level of T and B lymphocyte activity by binding to the beta2-adrenergic receptor (beta2AR). Norepinephrine 33-47 adrenergic receptor, beta 2 Mus musculus 144-151 9251764-3 1997 We have found that nitric oxide (NO) controls luteinizing hormone-releasing hormone (LHRH) release from the hypothalamus acting as a signal transducer in norepinephrine (NE)-induced LHRH release. Norepinephrine 154-168 gonadotropin releasing hormone 1 Rattus norvegicus 46-83 9251764-3 1997 We have found that nitric oxide (NO) controls luteinizing hormone-releasing hormone (LHRH) release from the hypothalamus acting as a signal transducer in norepinephrine (NE)-induced LHRH release. Norepinephrine 154-168 gonadotropin releasing hormone 1 Rattus norvegicus 85-89 17187001-4 2006 Dopamine-beta-hydroxylase (DBH) is an enzyme responsible for the conversion of dopamine into noradrenaline. Norepinephrine 93-106 dopamine beta-hydroxylase Homo sapiens 0-25 9251764-3 1997 We have found that nitric oxide (NO) controls luteinizing hormone-releasing hormone (LHRH) release from the hypothalamus acting as a signal transducer in norepinephrine (NE)-induced LHRH release. Norepinephrine 154-168 gonadotropin releasing hormone 1 Rattus norvegicus 182-186 9084425-3 1997 The comigration of noradrenaline, secretogranin II, and dopamine-beta-hydroxylase on sucrose-D2O gradient fractions indicates the presence of a population of noradrenaline-containing large dense-cored vesicles (LDCVs). Norepinephrine 158-171 dopamine beta-hydroxylase Homo sapiens 56-81 9003072-0 1997 Epinephrine and norepinephrine act as potent agonists at the recombinant human dopamine D4 receptor. Norepinephrine 16-30 dopamine receptor D4 Homo sapiens 79-99 17187001-4 2006 Dopamine-beta-hydroxylase (DBH) is an enzyme responsible for the conversion of dopamine into noradrenaline. Norepinephrine 93-106 dopamine beta-hydroxylase Homo sapiens 27-30 16788141-0 2006 Urea transporter UT-A1 and aquaporin-2 proteins decrease in response to angiotensin II or norepinephrine-induced acute hypertension. Norepinephrine 90-104 aquaporin 2 Rattus norvegicus 27-38 16788141-7 2006 Norepinephrine (7 days) increased BP, urine volume, sodium excretion, and decreased urine osmolality and UT-A1, AQP2, and NKCC2/BSC1 abundances, similar to ANG II. Norepinephrine 0-14 aquaporin 2 Rattus norvegicus 112-116 8988954-7 1997 RESULTS: CSF norepinephrine concentration was significantly higher in the patients with advanced Alzheimer"s disease (mean = 279 pg/ml, SD = 122) than in those with mild to moderate severity (mean = 198 pg/ml, SD = 89), normal older subjects (mean = 219 pg/ml, SD = 88), or normal young subjects (mean = 154 pg/ml, SD = 53). Norepinephrine 13-27 colony stimulating factor 2 Homo sapiens 9-12 16788141-11 2006 We conclude that decreases in UT-A1, AQP2, and NKCC2/BSC1 proteins may contribute to the diuresis and natriuresis that occur following ANG II or norepinephrine-induced acute hypertension and do not appear to involve ANG II stimulation of aldosterone or thirst. Norepinephrine 145-159 aquaporin 2 Rattus norvegicus 37-41 8988954-9 1997 CONCLUSIONS: Despite the loss of locus ceruleus neurons in Alzheimer"s disease, the aging-associated high concentration of CSF norepinephrine is retained in the earlier stages of Alzheimer"s disease and increases further as the disease progresses. Norepinephrine 127-141 colony stimulating factor 2 Homo sapiens 123-126 17041759-0 2006 Norepinephrine induces apoptosis in neonatal rat endothelial cells via a ROS-dependent JNK activation pathway. Norepinephrine 0-14 mitogen-activated protein kinase 8 Rattus norvegicus 87-90 17088501-2 2006 Monoamine oxidase A (MAO-A) is an enzyme that metabolizes monoamines, such as serotonin, norepinephrine, and dopamine. Norepinephrine 89-103 monoamine oxidase A Homo sapiens 0-19 17088501-2 2006 Monoamine oxidase A (MAO-A) is an enzyme that metabolizes monoamines, such as serotonin, norepinephrine, and dopamine. Norepinephrine 89-103 monoamine oxidase A Homo sapiens 21-26 16896926-1 2006 Monoamine oxidase A (MAOA) catalyses the oxidative deamination of biogenic amines including neurotransmitters, mainly norepinephrine and serotonin in the brain and peripheral tissues. Norepinephrine 118-132 monoamine oxidase A Homo sapiens 0-19 16896926-1 2006 Monoamine oxidase A (MAOA) catalyses the oxidative deamination of biogenic amines including neurotransmitters, mainly norepinephrine and serotonin in the brain and peripheral tissues. Norepinephrine 118-132 monoamine oxidase A Homo sapiens 21-25 16824047-0 2006 Abnormal compartmentalization of norepinephrine in mouse dentate gyrus in alpha-synuclein knockout and A30P transgenic mice. Norepinephrine 33-47 synuclein, alpha Mus musculus 74-89 9088896-10 1997 It may be assumed that noradrenaline released from degenerating sympathetic neurons located at the superior cervical ganglia (SCG) affects the GnRH-ergic terminals in the median eminence. Norepinephrine 23-36 gonadotropin releasing hormone 1 Rattus norvegicus 143-147 16824047-3 2006 We also found that alpha-synuclein, a presynaptic protein that plays a crucial role in dopamine compartmentalization in the striatum, is also involved in the compartmentalization of norepinephrine in the dentate gyrus. Norepinephrine 182-196 synuclein, alpha Mus musculus 19-34 16824047-5 2006 Addition of mutated human alpha-synuclein abolished the normal norepinephrine mobilization. Norepinephrine 63-77 synuclein alpha Homo sapiens 26-41 17030082-5 2006 In the spinal cord, norepinephrine released from descending pathways suppresses pain by inhibitory action on alpha-2A-adrenoceptors on central terminals of primary afferent nociceptors (presynaptic inhibition), by direct alpha-2-adrenergic action on pain-relay neurons (postsynaptic inhibition), and by alpha-1-adrenoceptor-mediated activation of inhibitory interneurons. Norepinephrine 20-34 adrenoceptor alpha 1D Homo sapiens 303-310 16735605-1 2006 Nicotine"s modulation of hippocampal noradrenergic neurotransmission may contribute to its mnemonic properties, but the nicotinic acetylcholine receptor (nAChR) subtypes that modulate terminal release of norepinephrine are unknown. Norepinephrine 204-218 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 154-159 18079991-4 2006 Peripheral and central administration of IL-1 also induces norepinephrine (NE) release in the brain, most markedly in the hypothalamus. Norepinephrine 59-73 interleukin 1 alpha Homo sapiens 41-45 17131588-5 2006 DBH encodes the enzyme that converts dopamine to noradrenaline and is crucial to catecholamine regulation. Norepinephrine 49-62 dopamine beta-hydroxylase Homo sapiens 0-3 16569708-2 2006 Although inactive in itself, the neuropeptide corticotropin releasing factor (CRF) strongly amplified the effect of BDNF, increasing the number of cells expressing TH and the active accumulation of noradrenaline by a factor of 2 to 3 via a mechanism that was nonmitogenic. Norepinephrine 198-211 corticotropin releasing hormone Homo sapiens 46-76 16725119-2 2006 Norepinephrine is degraded by monoamine oxidase A (MAOA) and catechol-O-methyl transferase (COMT). Norepinephrine 0-14 monoamine oxidase A Homo sapiens 30-49 16725119-2 2006 Norepinephrine is degraded by monoamine oxidase A (MAOA) and catechol-O-methyl transferase (COMT). Norepinephrine 0-14 monoamine oxidase A Homo sapiens 51-55 16574904-3 2006 Here we show that contraction of intact mouse tail arteries induced with 42 mmol/L KCl or 0.5 micromol/L noradrenaline was associated with a approximately 2-fold increase in the phosphorylation of the regulatory subunit of myosin phosphatase (SMPP-1M), MYPT1, at Thr696, which was reversed in arteries relaxed with urocortin. Norepinephrine 105-118 protein phosphatase 1, regulatory subunit 12A Mus musculus 253-258 16052243-3 2006 Since the neurotransmitter norepinephrine (NE) has both antidepressant and anticonvulsant properties, we speculated that NE transporter (NET) inhibitor antidepressants might be therapeutic candidates for comorbid individuals. Norepinephrine 27-41 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 121-135 16052243-3 2006 Since the neurotransmitter norepinephrine (NE) has both antidepressant and anticonvulsant properties, we speculated that NE transporter (NET) inhibitor antidepressants might be therapeutic candidates for comorbid individuals. Norepinephrine 27-41 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 137-140 16356685-4 2006 By contrast, knockout of the NE transporter (NET) gene, which elevates synaptic levels of norepinephrine, decreases seizure severity in mice fed normal diets. Norepinephrine 90-104 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 29-43 16356685-4 2006 By contrast, knockout of the NE transporter (NET) gene, which elevates synaptic levels of norepinephrine, decreases seizure severity in mice fed normal diets. Norepinephrine 90-104 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 45-48 9364202-2 1997 On the other hand, IR1 possess low affinity for norepinephrine (NE) and other catecholamines. Norepinephrine 48-62 nischarin Homo sapiens 19-22 16202396-2 2006 The monoamine oxidase-A (MAO-A) gene, coding for an enzyme primarily involved in serotonin and noradrenaline catabolism, presents a well-characterized functional polymorphism consisting of a variable number of tandem repeats in the promoter region, with high-activity and low-activity variants. Norepinephrine 95-108 monoamine oxidase A Homo sapiens 4-23 8922360-4 1996 Interestingly, both norepinephrine and isoproterenol reduced the level of leptin mRNA to about 20% of that found in untreated control cells in a dose-dependent fashion. Norepinephrine 20-34 leptin Homo sapiens 74-80 16202396-2 2006 The monoamine oxidase-A (MAO-A) gene, coding for an enzyme primarily involved in serotonin and noradrenaline catabolism, presents a well-characterized functional polymorphism consisting of a variable number of tandem repeats in the promoter region, with high-activity and low-activity variants. Norepinephrine 95-108 monoamine oxidase A Homo sapiens 25-30 16451083-1 2006 A novel series of dopamine beta-hydroxylase (DBH) inhibitors was designed and synthesized incorporating modifications to the core structure of nepicastat 3, with the principal aim of discovering potent DBH inhibitors exerting minimal effects on dopamine (DA) and noradrenaline (NA) levels in the central nervous system. Norepinephrine 263-276 dopamine beta-hydroxylase Rattus norvegicus 45-48 8961076-6 1996 Pretreatment of aortas with a cyclooxygenase inhibitor, indomethacin (10(-5) M) caused a slight decrease in the norepinephrine-induced contractions, suggesting that the factor could be a vasoconstrictor cyclooxygenase metabolite or a vasodilatory lipoxygenase or cytochrome P450 epoxygenase metabolite. Norepinephrine 112-126 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 247-259 8961076-8 1996 Whereas the lipoxygenase inhibitor, nordihydroguaiaretic acid (5 x 10(-5) M), caused a slight increase in the contractions to norepinephrine in cholesterol-fed rabbits compared with normal rabbits, the cytochrome P450 epoxygenase inhibitor, metyrapone (10(-4) M), produced a greater enhancement of norepinephrine-induced contractions in cholesterol-fed rabbits but had no effect on responses in the normal rabbits. Norepinephrine 126-140 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 12-24 8961076-8 1996 Whereas the lipoxygenase inhibitor, nordihydroguaiaretic acid (5 x 10(-5) M), caused a slight increase in the contractions to norepinephrine in cholesterol-fed rabbits compared with normal rabbits, the cytochrome P450 epoxygenase inhibitor, metyrapone (10(-4) M), produced a greater enhancement of norepinephrine-induced contractions in cholesterol-fed rabbits but had no effect on responses in the normal rabbits. Norepinephrine 298-312 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 12-24 8961076-9 1996 Characterization of [3H]arachidonic acid metabolism in cholesterol-fed aortic tissue indicated that norepinephrine stimulated the synthesis of both lipoxygenase and epoxygenase metabolites in an endothelium-dependent manner. Norepinephrine 100-114 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 148-160 16462018-6 2006 COMT activities were assessed by measuring normetanephrine with the use of norepinephrine as an endogenous substrate. Norepinephrine 75-89 catechol-O-methyltransferase Rattus norvegicus 0-4 16931444-1 2006 Dopamine-beta-hydroxylase (DbetaH), the enzyme that synthesizes noradrenaline from dopamine, was studied in the locus coeruleus (LC) of neonate rats exposed to 2,4-dichlorophenoxyacetic acid (2,4-D) through lactation for 14 days (from PND 9 to 22). Norepinephrine 64-77 dopamine beta-hydroxylase Rattus norvegicus 0-25 9004162-3 1996 In this study, by means of binding assays on cardiac membranes or by evaluating contractility and cAMP levels of isolated rat atria in the presence of IL-2, we demonstrate that IL-2 may indirectly stimulate beta-adrenergic-mediated function by triggering the presynaptic release of norepinephrine (NE) on isolated rat atria. Norepinephrine 282-296 interleukin 2 Rattus norvegicus 177-181 16931444-1 2006 Dopamine-beta-hydroxylase (DbetaH), the enzyme that synthesizes noradrenaline from dopamine, was studied in the locus coeruleus (LC) of neonate rats exposed to 2,4-dichlorophenoxyacetic acid (2,4-D) through lactation for 14 days (from PND 9 to 22). Norepinephrine 64-77 dopamine beta-hydroxylase Rattus norvegicus 27-33 17184598-5 2006 DBH is an enzyme responsible for the conversion of dopamine into noradrenaline. Norepinephrine 65-78 dopamine beta-hydroxylase Homo sapiens 0-3 16139427-1 2005 Monoamine oxidase A (MAO-A) is an enzyme involved in the metabolism of monoamine neurotransmitters such as dopamine, serotonin, and noradrenaline in the brain. Norepinephrine 132-145 monoamine oxidase A Homo sapiens 0-19 16139427-1 2005 Monoamine oxidase A (MAO-A) is an enzyme involved in the metabolism of monoamine neurotransmitters such as dopamine, serotonin, and noradrenaline in the brain. Norepinephrine 132-145 monoamine oxidase A Homo sapiens 21-26 16307583-2 2005 In Phox2a mutant mice, which do not express A6 neurons, we previously hypothesized that the release of endogenous norepinephrine by A6 neurons is required for a normal respiratory rhythm to occur at birth. Norepinephrine 114-128 paired-like homeobox 2a Mus musculus 3-9 16358231-4 2005 On univariate analysis, UTN was inversely related to heart rate (r=-0.24), dialysis treatment duration (r=-0.27), norepinephrine (r=-0.28), neuropeptide Y (NPY) (r=-0.66), brain natriuretic peptide (BNP) (r=-0.41) and atrial natriuretic peptide (ANP) (r=-0.28) (all p<0.008). Norepinephrine 114-128 urotensin 2 Homo sapiens 24-27 8982651-0 1996 Neuropeptide Y potentiates noradrenaline-induced contraction through the neuropeptide Y Y1 receptor. Norepinephrine 27-40 neuropeptide Y Homo sapiens 0-14 8982651-0 1996 Neuropeptide Y potentiates noradrenaline-induced contraction through the neuropeptide Y Y1 receptor. Norepinephrine 27-40 neuropeptide Y Homo sapiens 73-87 8982651-2 1996 Neuropeptide Y significantly potentiated the noradrenaline-induced contraction in non-incubated vessels (pEC50 6.4 +/- 0.2 vs. 5.9 +/- 0.2) and in vessels incubated with 1 microM Sense oligodeoxynucleotide (Sense) (pEC50 6.0 +/- 0.1 vs. 5.6 +/- 0.2). Norepinephrine 45-58 neuropeptide Y Homo sapiens 0-14 8982651-6 1996 On the basis of our results we conclude that the neuropeptide Y-induced potentiation of the noradrenaline-induced contraction is mediated by the neuropeptide Y Y1 receptor. Norepinephrine 92-105 neuropeptide Y Homo sapiens 49-63 8982651-6 1996 On the basis of our results we conclude that the neuropeptide Y-induced potentiation of the noradrenaline-induced contraction is mediated by the neuropeptide Y Y1 receptor. Norepinephrine 92-105 neuropeptide Y Homo sapiens 145-159 16040158-1 2005 In the prostatic portion of rat vas deferens, activation of adenosine A 2B-receptors, beta2-adrenoceptors, adenylyl cyclase or protein kinase A caused a facilitation of noradrenaline release. Norepinephrine 169-182 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 127-143 9116208-0 1996 Neuropeptide Y elevates intracellular Ca2+ and evokes noradrenaline release in SH-SY5Y cells. Norepinephrine 54-67 neuropeptide Y Homo sapiens 0-14 16079262-2 2005 The contractile response to noradrenaline (NA) in organ-cultured diabetic rat aortae cultured with insulin or IGF-I was significantly greater than the corresponding responses in (a) diabetic rat aortae cultured in serum-free medium and (b) control rat aortae cultured with insulin or IGF-I. Norepinephrine 28-41 insulin-like growth factor 1 Rattus norvegicus 110-115 8945965-5 1996 However, in the saline-infused subjects there was a positive correlation between the percent change in plasma norepinephrine concentrations and the percent change in muscle LPL activity (r = 0.826, P < 0.05). Norepinephrine 110-124 lipoprotein lipase Homo sapiens 173-176 8930173-9 1996 Norepinephrine displayed, respectively, 18- and 31-fold selectivity for the high affinity state of the alpha-2C adrenoceptor as compared to alpha-2A- or alpha-2B adrenoceptors, and was > 100,000- fold selective over platelet I1-imidazoline sites. Norepinephrine 0-14 nischarin Homo sapiens 228-230 8921301-3 1996 The modulation of IAHP by noradrenaline has previously been shown to be mediated by beta 1 receptors, cyclic AMP and protein kinase A, but not by alpha receptors. Norepinephrine 26-39 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 117-133 16079262-2 2005 The contractile response to noradrenaline (NA) in organ-cultured diabetic rat aortae cultured with insulin or IGF-I was significantly greater than the corresponding responses in (a) diabetic rat aortae cultured in serum-free medium and (b) control rat aortae cultured with insulin or IGF-I. Norepinephrine 28-41 insulin-like growth factor 1 Rattus norvegicus 284-289 15809070-5 2005 Treatment with Ucn 2 increased noradrenaline secretion and induced phosphorylation of PKA and Erk1/2. Norepinephrine 31-44 urocortin 2 Rattus norvegicus 15-20 15809070-9 2005 Thus, Ucn 2 induces noradrenaline secretion and TH phosphorylation through the PKA pathway and the PKA-Erk1/2 pathway, respectively. Norepinephrine 20-33 urocortin 2 Rattus norvegicus 6-11 15626688-0 2005 Norepinephrine induces endoplasmic reticulum stress and downregulation of norepinephrine transporter density in PC12 cells via oxidative stress. Norepinephrine 0-14 solute carrier family 6 member 2 Rattus norvegicus 74-100 15869489-0 2005 A role for norepinephrine in the regulation of context-dependent ZENK expression in male zebra finches (Taeniopygia guttata). Norepinephrine 11-25 early growth response protein 1 Taeniopygia guttata 65-69 15615865-7 2005 In functional studies, coexpression with beta2-AR significantly enhanced the coupling of alpha1D-AR to norepinephrine-stimulated Ca2+ mobilization. Norepinephrine 103-117 adrenoceptor alpha 1D Homo sapiens 89-99 16097364-1 2005 Dopamine-beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine and is released from sympathetic neurons into the circulation. Norepinephrine 72-86 dopamine beta-hydroxylase Homo sapiens 0-25 16097364-1 2005 Dopamine-beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine and is released from sympathetic neurons into the circulation. Norepinephrine 72-86 dopamine beta-hydroxylase Homo sapiens 27-30 15669056-10 2005 Some long projection neurons such as the pyramidal, mitral, principal neurons of several cranial nuclei, and presumably monoaminergic cells containing noradrenalin, dopamine, and serotonin, expressed high levels of L1cam. Norepinephrine 151-163 L1 cell adhesion molecule Mus musculus 215-220 15494609-7 2005 Remarkably, mRNA for phenylethanolamine N-methyltransferase (PNMT), which converts norepinephrine to epinephrine, was reduced (P < 0.05 vs. all) 40% only in D-hypo rats. Norepinephrine 83-97 phenylethanolamine-N-methyltransferase Rattus norvegicus 21-59 15494609-7 2005 Remarkably, mRNA for phenylethanolamine N-methyltransferase (PNMT), which converts norepinephrine to epinephrine, was reduced (P < 0.05 vs. all) 40% only in D-hypo rats. Norepinephrine 83-97 phenylethanolamine-N-methyltransferase Rattus norvegicus 61-65 15813642-5 2005 In addition, the SP/NK1R system shows significant spatial overlap with neurotransmitters such as serotonin and noradrenaline (norepinephrine), which are known to be involved in the regulation of stress, mood and anxiety. Norepinephrine 111-124 tachykinin receptor 1 Homo sapiens 20-24 15813642-5 2005 In addition, the SP/NK1R system shows significant spatial overlap with neurotransmitters such as serotonin and noradrenaline (norepinephrine), which are known to be involved in the regulation of stress, mood and anxiety. Norepinephrine 126-140 tachykinin receptor 1 Homo sapiens 20-24 16075814-5 2005 UCP1 is only expressed in BAT through the synergistic action of norepinephrine (NE) and thyroid hormones in animals exposed to cold and to a lesser degree after meals. Norepinephrine 64-78 uncoupling protein 1 Homo sapiens 0-4 15990460-1 2005 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine and these neurotransmitters are hypothesized to be involved in the cognitive function of humans. Norepinephrine 108-122 monoamine oxidase A Homo sapiens 0-19 15990460-1 2005 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine and these neurotransmitters are hypothesized to be involved in the cognitive function of humans. Norepinephrine 108-122 monoamine oxidase A Homo sapiens 21-25 16110245-1 2005 Monoamine oxidase A (MAOA), a mitochondrial outer membrane enzyme, degrades biogenic amines including norepinephrine, dopamine and serotonin, which have been implicated in the expression of personality traits. Norepinephrine 102-116 monoamine oxidase A Homo sapiens 0-19 16110245-1 2005 Monoamine oxidase A (MAOA), a mitochondrial outer membrane enzyme, degrades biogenic amines including norepinephrine, dopamine and serotonin, which have been implicated in the expression of personality traits. Norepinephrine 102-116 monoamine oxidase A Homo sapiens 21-25 15569098-0 2004 Reduced sympathetic responsiveness as well as plasma and tissue noradrenaline concentration in growth hormone transgenic mice. Norepinephrine 64-77 growth hormone Mus musculus 95-109 15358679-0 2004 Norepinephrine induction of mitogen-activated protein kinase phosphatase-1 expression in rat pinealocytes: distinct roles of alpha- and beta-adrenergic receptors. Norepinephrine 0-14 dual specificity phosphatase 1 Rattus norvegicus 28-74 15358679-1 2004 In this study, we investigated the mechanisms through which norepinephrine (NE) regulates MAPK phosphatase-1 (MKP-1) expression in rat pinealocytes. Norepinephrine 60-74 dual specificity phosphatase 1 Rattus norvegicus 90-108 15358679-1 2004 In this study, we investigated the mechanisms through which norepinephrine (NE) regulates MAPK phosphatase-1 (MKP-1) expression in rat pinealocytes. Norepinephrine 60-74 dual specificity phosphatase 1 Rattus norvegicus 110-115 15447813-1 2004 Antidepressants, such as serotonin or noradrenaline reuptake inhibitors (e.g. fluoxetine, nefadozone) or 5-HT1A agonists (flibanserin), desensitize the 5-HT1A autoreceptor, which may contribute to their clinical efficacy. Norepinephrine 38-51 5-hydroxytryptamine receptor 1A Homo sapiens 152-158 15564894-1 2004 Monoamine oxidase A (MAOA) has been suggested to be involved in human behaviour and physiology due to its key role in the metabolism of several different biological amines including the neurotransmitters serotonin, norepinephrin and dopamine.Recently, a 30 bp repeat in the MAOA gene promoter (uMAOA) has been demonstrated to be polymorphic and to affect transcriptional activity. Norepinephrine 215-228 monoamine oxidase A Homo sapiens 0-19 15564894-1 2004 Monoamine oxidase A (MAOA) has been suggested to be involved in human behaviour and physiology due to its key role in the metabolism of several different biological amines including the neurotransmitters serotonin, norepinephrin and dopamine.Recently, a 30 bp repeat in the MAOA gene promoter (uMAOA) has been demonstrated to be polymorphic and to affect transcriptional activity. Norepinephrine 215-228 monoamine oxidase A Homo sapiens 21-25 15527789-0 2004 Mitogen-activated protein kinase phosphatase-1 (MKP-1): >100-fold nocturnal and norepinephrine-induced changes in the rat pineal gland. Norepinephrine 83-97 dual specificity phosphatase 1 Rattus norvegicus 0-46 15527789-0 2004 Mitogen-activated protein kinase phosphatase-1 (MKP-1): >100-fold nocturnal and norepinephrine-induced changes in the rat pineal gland. Norepinephrine 83-97 dual specificity phosphatase 1 Rattus norvegicus 48-53 15527789-1 2004 The norepinephrine-driven increase in mitogen-activated protein kinase (MAPK) activity is part of the mechanism that regulates arylalkylamine N-acetyltransferase (AA-NAT) activity in the rat pineal gland. Norepinephrine 4-18 aralkylamine N-acetyltransferase Rattus norvegicus 127-161 15527789-1 2004 The norepinephrine-driven increase in mitogen-activated protein kinase (MAPK) activity is part of the mechanism that regulates arylalkylamine N-acetyltransferase (AA-NAT) activity in the rat pineal gland. Norepinephrine 4-18 aralkylamine N-acetyltransferase Rattus norvegicus 163-169 15527789-3 2004 MKP-1 expression was regulated by norepinephrine acting through both alpha- and beta-adrenergic receptors. Norepinephrine 34-48 dual specificity phosphatase 1 Rattus norvegicus 0-5 15505174-1 2004 Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine (NE). Norepinephrine 72-86 dopamine beta-hydroxylase Homo sapiens 0-25 15505174-1 2004 Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine (NE). Norepinephrine 72-86 dopamine beta-hydroxylase Homo sapiens 27-30 15509759-1 2004 The neuropeptide corticotropin-releasing hormone (CRH) activates locus ceruleus (LC) neurons, thereby increasing norepinephrine levels throughout the CNS. Norepinephrine 113-127 corticotropin releasing hormone Homo sapiens 17-48 15509759-1 2004 The neuropeptide corticotropin-releasing hormone (CRH) activates locus ceruleus (LC) neurons, thereby increasing norepinephrine levels throughout the CNS. Norepinephrine 113-127 corticotropin releasing hormone Homo sapiens 50-53 15464018-4 2004 In addition, the detection of the diverse receptor populations for ATP, noradrenaline and NPY in blood vessels, either in the smooth muscle, endothelial cells or nerve endings, further contribute to the notion that sympathetic vascular reflexes encompass the orchestrated action of the noradrenaline and ATP, and their modulation by NPY. Norepinephrine 286-299 neuropeptide Y Homo sapiens 90-93 15464018-4 2004 In addition, the detection of the diverse receptor populations for ATP, noradrenaline and NPY in blood vessels, either in the smooth muscle, endothelial cells or nerve endings, further contribute to the notion that sympathetic vascular reflexes encompass the orchestrated action of the noradrenaline and ATP, and their modulation by NPY. Norepinephrine 286-299 neuropeptide Y Homo sapiens 333-336 15500541-0 2004 Interaction between norepinephrine, oxytocin, and nitric oxide in the stimulation of gonadotropin-releasing hormone release from proestrous rat basal hypothalamus explants. Norepinephrine 20-34 gonadotropin releasing hormone 1 Rattus norvegicus 85-115 8876997-0 1996 Poly(ADP-ribose) polymerase inhibitors protect against MPTP-induced depletions of striatal dopamine and cortical noradrenaline in C57B1/6 mice. Norepinephrine 113-126 poly (ADP-ribose) polymerase family, member 1 Mus musculus 0-27 8842578-3 1996 The regressions of salivary alpha-amylase on plasma norepinephrine (NE) concentrations were significant for both exercise (P < 0.001) and examination (P < 0.01) protocols. Norepinephrine 52-66 amylase alpha 1A Homo sapiens 19-41 8640984-12 1996 Bosentan attenuated norepinephrine-induced increases in ventricular weight, ratio of RNA to protein, and expression of skeletal alpha-actin mRNA and beta-myosin heavy chain mRNA at 5 days, but it did not attenuate increased ventricular expression of atrial natriuretic factor mRNA. Norepinephrine 20-34 natriuretic peptide A Rattus norvegicus 250-275 8829205-0 1996 Enhancement of brain noradrenaline and dopamine turnover by thyrotropin-releasing hormone and its analogue NS-3 in mice and rats. Norepinephrine 21-34 thyrotropin releasing hormone Mus musculus 60-89 8631897-2 1996 Induction of the promoter by transforming growth factor beta or norepinephrine requires serum response factor (SRF) and TEF-1; expression is inhibited by YY1. Norepinephrine 64-78 serum response factor Homo sapiens 88-109 8631897-2 1996 Induction of the promoter by transforming growth factor beta or norepinephrine requires serum response factor (SRF) and TEF-1; expression is inhibited by YY1. Norepinephrine 64-78 serum response factor Homo sapiens 111-114 8627568-8 1996 blocked the suppressant effect of microiontophoretically applied norepinephrine (NE) on the firing activity of CA3 dorsal hippocampus pyramidal neurons, indicating their antagonistic effects on postsynaptic alpha-2 adrenoceptors. Norepinephrine 65-79 carbonic anhydrase 3 Rattus norvegicus 111-114 8792338-7 1996 Overall, a 30-fold range of GTP cyclohydrolase I mRNA expression was observed, with the transcript being significantly more abundant in serotonin than in dopamine or norepinephrine/epinephrine neurons. Norepinephrine 166-180 GTP cyclohydrolase 1 Rattus norvegicus 28-48 8792338-10 1996 Norepinephrine neurons of the locus coeruleus (A6) and subcoeruleus (A6v) exhibited significantly higher levels of GTP cyclohydrolase I mRNA than did neurons in other norepinephrine (A1 and A2) or epinephrine (C1 and C2) cell groups. Norepinephrine 0-14 GTP cyclohydrolase 1 Rattus norvegicus 115-135 8635209-1 1996 We have previously shown that extracellular ATP, like norepinephrine (NE) and many other hypertrophy-inducing agents, increases expression of the immediate-early genes c-fos and junB in cultured neonatal cardiac myocytes but that the intracellular signaling pathways activated by ATP and responsible for these changes differ from those stimulated by NE. Norepinephrine 54-68 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 168-173 8636125-3 1996 Rab3A and Rab3B both targeted to norepinephrine (NE)-containing large dense core vesicles (LDCVs) when stably expressed in PC12 cells, as determined by immunofluorescence and membrane fractionation. Norepinephrine 33-47 RAB3B, member RAS oncogene family Rattus norvegicus 10-15 8678123-1 1996 The monoamine oxidases (MAO-A and MAO-B) are the enzymes primarily responsible for the degradation of amine neurotransmitters, such as dopamine, norepinephrine, and serotonin. Norepinephrine 145-159 monoamine oxidase B Homo sapiens 34-39 8598500-8 1996 These data demonstrate that adrenaline and noradrenaline modulate the migratory capacity of human NK cells via spleen-independent beta 2-adrenoceptor mechanism. Norepinephrine 43-56 adrenoceptor beta 2 Homo sapiens 130-149 15500541-1 2004 In the proestrous female rat, norepinephrine, oxytocin and nitric oxide (NO) all participate in the regulation of the preovulatory gonadotropin-releasing hormone (GnRH) surge. Norepinephrine 30-44 gonadotropin releasing hormone 1 Rattus norvegicus 131-161 15500541-1 2004 In the proestrous female rat, norepinephrine, oxytocin and nitric oxide (NO) all participate in the regulation of the preovulatory gonadotropin-releasing hormone (GnRH) surge. Norepinephrine 30-44 gonadotropin releasing hormone 1 Rattus norvegicus 163-167 15500541-3 2004 The present studies were undertaken to determine whether norepinephrine could also stimulate GnRH release from similar explants, to identify the receptors responsible for this effect and to investigate interactions between norepinephrine, oxytocin and NO. Norepinephrine 57-71 gonadotropin releasing hormone 1 Rattus norvegicus 93-97 15500541-4 2004 Norepinephrine significantly stimulated GnRH release from proestrous basal hypothalamus explants, and coadministration of the alpha(1)-adrenergic antagonist prazosin blocked this effect. Norepinephrine 0-14 gonadotropin releasing hormone 1 Rattus norvegicus 40-44 15500541-5 2004 Combined administration of oxytocin and norepinephrine stimulated significantly more GnRH release than either drug alone, and this stimulation was blocked by inhibition of NO synthase, or by an oxytocin receptor antagonist. Norepinephrine 40-54 gonadotropin releasing hormone 1 Rattus norvegicus 85-89 15500541-9 2004 These results demonstrate for the first time that oxytocin and norepinephrine dramatically stimulate GnRH release from basal hypothalamus explants harvested on the afternoon of proestrus, and indicate that this involves oxytocin receptor and NO-dependent mechanisms. Norepinephrine 63-77 gonadotropin releasing hormone 1 Rattus norvegicus 101-105 15363956-0 2004 Brain phospholipase C-diacylglycerol lipase pathway is involved in vasopressin-induced release of noradrenaline and adrenaline from adrenal medulla in rats. Norepinephrine 98-111 lipase G, endothelial type Rattus norvegicus 13-19 15363956-13 2004 These results suggest that vasopressin evokes the release of noradrenaline and adrenaline from adrenal medulla by the brain PLC- and diacylglycerol lipase-dependent mechanisms in rats. Norepinephrine 61-74 lipase G, endothelial type Rattus norvegicus 148-154 15495941-1 2004 The DBH gene encodes dopamine-beta-hydroxylase (DbetaH), the enzyme that catalyses the formation of norepinephrine from dopamine. Norepinephrine 100-114 dopamine beta-hydroxylase Homo sapiens 4-7 7594065-14 1995 There was a significant correlation between plasma levels of adrenomedullin and norepinephrine (r = 0.618, p < 0.001), atrial natriuretic peptide (r = 0.696, p < 0.001) and brain natriuretic peptide (r = 0.692, p < 0.001). Norepinephrine 80-94 adrenomedullin Homo sapiens 61-75 7669062-1 1995 Acute injection of either noradrenaline or isoprenaline in mice activated both brown (BAT) and white (WAT) adipose tissue hormone-sensitive lipase activity (HSL). Norepinephrine 26-39 lipase, hormone sensitive Mus musculus 157-160 15495941-1 2004 The DBH gene encodes dopamine-beta-hydroxylase (DbetaH), the enzyme that catalyses the formation of norepinephrine from dopamine. Norepinephrine 100-114 dopamine beta-hydroxylase Homo sapiens 21-46 15495941-1 2004 The DBH gene encodes dopamine-beta-hydroxylase (DbetaH), the enzyme that catalyses the formation of norepinephrine from dopamine. Norepinephrine 100-114 dopamine beta-hydroxylase Homo sapiens 48-54 15306230-6 2004 CONCLUSIONS: In rat tail artery, the A(2A) receptor-mediated facilitation of noradrenaline release requires activation of both PKC and PKA, and PKA activation seems to occur downstream of PKC activation. Norepinephrine 77-90 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 135-138 7539818-0 1995 Human galanin reduces plasma norepinephrine levels in man. Norepinephrine 29-43 galanin and GMAP prepropeptide Homo sapiens 6-13 15242813-3 2004 We did not identify an inhibition at the level of the adrenergic receptors, but a first site of inhibition was identified as the generation of cAMP by adenylyl cyclase; this led to inhibition of norepinephrine-induced expression of the uncoupling protein-1 (UCP1) gene and reduced norepinephrine-induced lipolysis as secondary effects. Norepinephrine 195-209 uncoupling protein 1 Homo sapiens 236-262 7601207-5 1995 Neuropeptide Y, but not peptide YY or neuropeptide Y analogues, evoked the release of noradrenaline. Norepinephrine 86-99 pro-neuropeptide Y Cavia porcellus 0-14 15242772-2 2004 Utilizing a three-dimensional (3D) collagen assay and computer-assisted, continuous single cell tracking, we investigated the basic parameters for both the spontaneous and norepinephrine-induced migration of highly metastatic MBA-MB-468 breast, PC-3 prostate, and SW 480 colon carcinoma cells. Norepinephrine 172-186 chromobox 8 Homo sapiens 245-249 15262269-5 2004 Furthermore, in a different model of serotonergic and noradrenergic degeneration, BDNF protein levels were similarly increased in response to depletions in hippocampal serotonin and norepinephrine caused by the chemical neurotoxin 1-methyl-4-(2"-aminophenyl)-1,2,3,6-tetrahydropyridine (2"-NH2-MPTP). Norepinephrine 182-196 brain derived neurotrophic factor Mus musculus 82-86 15027894-9 2004 Interaction revealed that subjects with high cortisol/low noradrenaline had higher PAI-1 than subjects with low cortisol/high noradrenaline (P=0.038). Norepinephrine 58-71 serpin family E member 1 Homo sapiens 83-88 15173897-0 2004 Impact of substance P receptor antagonism on the serotonin and norepinephrine systems: relevance to the antidepressant/anxiolytic response. Norepinephrine 63-77 tachykinin receptor 1 Rattus norvegicus 10-30 7620718-4 1995 Both the ATP-site competitors (genistein and its inactive analogue, daidzein) and the substrate-site competitors (tyrphostins A-23, A-47 and the inactive analogue, A-1) reversibly inhibited noradrenaline (NA, (10 microM)) and KCl (125 mM) induced contractions, concentration-dependently. Norepinephrine 190-203 UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus 164-167 7864642-8 1995 These results suggest that laparotomy releases glucocorticoids and neural noradrenaline that stimulates alpha 1-adrenergic receptors, thereby leading to the serine dehydratase gene expression. Norepinephrine 74-87 serine dehydratase Rattus norvegicus 157-175 7830064-1 1995 Cyclic GMP accumulation in pinealocytes is elevated > 100-fold by norepinephrine (NE) through a mechanism involving conjoint activation of alpha 1- and beta 1-adrenergic receptors. Norepinephrine 69-83 5'-nucleotidase, cytosolic II Homo sapiens 7-10 7840338-4 1995 The catecholamine output from the adrenal glands in the sham group significantly increased (P < 0.05), reaching a maximum level 45 min after insulin injection from a control value for epinephrine of 86.35 +/- 26.65 ng/min and for norepinephrine of 32.14 +/- 11.68 ng/min to 659.03 +/- 269.39 and 181.21 +/- 63.03 ng/min, respectively. Norepinephrine 233-247 insulin Canis lupus familiaris 144-151 7839857-3 1994 Two series of experiments were performed on vessels: the dose-response relationship of PACAP-38 (10(-10)-10(-7) M) was established on noradrenaline- (NA, 10(-6) M) contracted vessels. Norepinephrine 134-147 LOW QUALITY PROTEIN: pituitary adenylate cyclase-activating polypeptide Oryctolagus cuniculus 87-92 7882162-2 1994 We now demonstrated that the addition of elastin peptides to rat aorta rings precontracted with noradrenaline produced an endothelium-dependent vasorelaxation. Norepinephrine 96-109 elastin Rattus norvegicus 41-48 15113605-1 2004 Norepinephrine transporter (NET) mediates the active removal of norepinephrine (NE) released from sympathetic nerve terminals via reuptake, and NET function and expression can be regulated by cocaine. Norepinephrine 64-78 solute carrier family 6 member 2 Rattus norvegicus 0-26 7947060-1 1994 Neuropeptide Y (NPY) is a potent vasoconstrictive polypeptide colocalized with norepinephrine in sympathetic neurons. Norepinephrine 79-93 neuropeptide Y Canis lupus familiaris 0-14 7947060-1 1994 Neuropeptide Y (NPY) is a potent vasoconstrictive polypeptide colocalized with norepinephrine in sympathetic neurons. Norepinephrine 79-93 neuropeptide Y Canis lupus familiaris 16-19 7921614-13 1994 It is concluded that PKA activation is involved in the noradrenaline release enhancing effect of the two 8-substituted cyclic GMP analogues, whereas a cyclic GMP/PKG-operated pathway accounts for the inhibitory effects of the cyclic GMP and its analogues on vascular smooth muscle contraction. Norepinephrine 55-68 5'-nucleotidase, cytosolic II Homo sapiens 126-129 8013086-2 1994 Pretreatment with TGF-beta 1 potentiated norepinephrine (NE)-induced and stretch-induced (+10% and +20% elongation, for 30 minutes) c-fos mRNA expression by 2.2-fold, whereas TGF-beta 1 alone did not induce c-fos mRNA expression in Northern blot analysis. Norepinephrine 41-55 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 132-137 15113605-1 2004 Norepinephrine transporter (NET) mediates the active removal of norepinephrine (NE) released from sympathetic nerve terminals via reuptake, and NET function and expression can be regulated by cocaine. Norepinephrine 64-78 solute carrier family 6 member 2 Rattus norvegicus 28-31 15030373-13 2004 During ETA blockade, noradrenaline increased after haemorrhage instead of adrenaline, and the MAP recovery after retransfusion was blunted. Norepinephrine 21-34 endothelin receptor type A Canis lupus familiaris 7-10 15127327-16 2004 A significant (p < 0.001) increase in IN/ME perfusate concentrations of dopamine and noradrenaline metabolites was noted in PRL-treated ewes in comparison with those in the control. Norepinephrine 88-101 prolactin Ovis aries 127-130 14715701-5 2004 Epinephrine and norepinephrine up-regulated MMP-1 and potentiated LPS-induced expression of MMP-1 in peripheral blood monocytes and monocyte-derived macrophages. Norepinephrine 16-30 matrix metallopeptidase 1 Homo sapiens 44-49 14715701-5 2004 Epinephrine and norepinephrine up-regulated MMP-1 and potentiated LPS-induced expression of MMP-1 in peripheral blood monocytes and monocyte-derived macrophages. Norepinephrine 16-30 matrix metallopeptidase 1 Homo sapiens 92-97 15067320-6 2004 NGF expression, cardiac sympathetic innervation, and norepinephrine concentration were specifically reduced in endothelin-1-deficient mouse hearts, but not in angiotensinogen-deficient mice. Norepinephrine 53-67 endothelin 1 Mus musculus 111-123 14757141-6 2004 These results indicate that a large part of basal release of noradrenaline in the basolateral nucleus of the amygdala is under tonic inhibitory control by endogenous nociceptin/orphanin FQ through the N/OFQ peptide receptors localized within the basolateral nucleus of the amygdala. Norepinephrine 61-74 prepronociceptin Rattus norvegicus 177-188 14736843-0 2004 M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals. Norepinephrine 46-60 potassium voltage-gated channel subfamily Q member 2 Rattus norvegicus 22-27 14741406-8 2004 These data show that the expression of Per1 and Cry2 in the rat pineal gland is regulated by the clock-driven changes in norepinephrine, in a similar manner to the melatonin rhythm-generating enzyme arylalkylamine N-acetyltransferase. Norepinephrine 121-135 cryptochrome circadian regulator 2 Rattus norvegicus 48-52 14732207-0 2004 Norepinephrine-induced acute heart failure in transgenic mice overexpressing erythropoietin. Norepinephrine 0-14 erythropoietin Mus musculus 77-91 15539858-2 2004 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine. Norepinephrine 108-122 monoamine oxidase A Homo sapiens 0-19 15539858-2 2004 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine. Norepinephrine 108-122 monoamine oxidase A Homo sapiens 21-25 12084707-8 2002 Transient transfection assay using luciferase reporter constructs also indicates that the two half-site CREs are involved in transcriptional regulation of Ucp1 in response to norepinephrine and cAMP. Norepinephrine 175-189 uncoupling protein 1 Homo sapiens 155-159 7963511-11 1994 Moreover, the change in systolic blood pressure (SBP) between weeks 0 and 2 was negatively correlated with the change in urinary kallikrein activity between weeks 0 and 2, the change in total dopamine between weeks 0 and 2 was negatively correlated with the change in diastolic blood pressure in the same period, and the change in SBP between weeks 0 and 10 was positively correlated with the change in total noradrenaline in the same period in the exercise group. Norepinephrine 409-422 kallikrein related peptidase 4 Homo sapiens 129-139 12383975-3 2002 To this aim, we carried out the present immunohistochemistry study using two antibodies raised against dopamine beta-hydroxylase (DBH), the enzyme responsible for the conversion of dopamine into noradrenaline, and against the dopamine transporter (DAT), as markers for noradrenergic and dopaminergic fibers, respectively. Norepinephrine 195-208 dopamine beta-hydroxylase Rattus norvegicus 103-128 8187273-1 1994 It is well-documented that norepinephrine (NE) induces the expression of immediate-early genes (IEGs), such as c-fos, c-jun, and jun-B, in cultured neonatal heart cells and leads to cell growth without cell division (ie, hypertrophy). Norepinephrine 27-41 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 111-116 8187273-1 1994 It is well-documented that norepinephrine (NE) induces the expression of immediate-early genes (IEGs), such as c-fos, c-jun, and jun-B, in cultured neonatal heart cells and leads to cell growth without cell division (ie, hypertrophy). Norepinephrine 27-41 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 118-123 12383975-3 2002 To this aim, we carried out the present immunohistochemistry study using two antibodies raised against dopamine beta-hydroxylase (DBH), the enzyme responsible for the conversion of dopamine into noradrenaline, and against the dopamine transporter (DAT), as markers for noradrenergic and dopaminergic fibers, respectively. Norepinephrine 195-208 dopamine beta-hydroxylase Rattus norvegicus 130-133 12202245-3 2002 Alpha(2B)-AR bind natural (adrenaline and noradrenaline) and synthetic ligands with different affinities to mediate a variety of physiological and pharmacological responses. Norepinephrine 42-55 adrenoceptor alpha 2B Homo sapiens 0-12 12172218-0 2002 Enhanced vasoconstriction to endothelin-1, angiotensin II and noradrenaline in carriers of the GNB3 825T allele in the skin microcirculation. Norepinephrine 62-75 G protein subunit beta 3 Homo sapiens 95-99 8045100-2 1994 Intravenous infusion of noradrenaline (0.5 microgram/kg per min for 2 hr) totally suppressed plasma GH concentrations. Norepinephrine 24-37 somatotropin Ovis aries 100-102 8045100-3 1994 Concomitant treatment of animals with the beta-adrenergic antagonist propranolol completely blocked the noradrenaline-induced suppression of GH. Norepinephrine 104-117 somatotropin Ovis aries 141-143 8045100-5 1994 To further investigate the central adrenergic regulation of GH secretion 10 micrograms of noradrenaline or adrenaline was microinjected (1 microliter) directly into the preoptic area of the hypothalamus of ovariectomized ewes. Norepinephrine 90-103 somatotropin Ovis aries 60-62 8045100-6 1994 When the time of injection coincided with a GH trough period, both noradrenaline and adrenaline caused an increase in plasma GH concentrations, whereas if the injection coincided with an endogenous pulse of GH no additional GH response was obtained. Norepinephrine 67-80 somatotropin Ovis aries 44-46 8045100-6 1994 When the time of injection coincided with a GH trough period, both noradrenaline and adrenaline caused an increase in plasma GH concentrations, whereas if the injection coincided with an endogenous pulse of GH no additional GH response was obtained. Norepinephrine 67-80 somatotropin Ovis aries 125-127 8045100-6 1994 When the time of injection coincided with a GH trough period, both noradrenaline and adrenaline caused an increase in plasma GH concentrations, whereas if the injection coincided with an endogenous pulse of GH no additional GH response was obtained. Norepinephrine 67-80 somatotropin Ovis aries 125-127 8045100-6 1994 When the time of injection coincided with a GH trough period, both noradrenaline and adrenaline caused an increase in plasma GH concentrations, whereas if the injection coincided with an endogenous pulse of GH no additional GH response was obtained. Norepinephrine 67-80 somatotropin Ovis aries 125-127 7907526-2 1994 Previous work has shown that direct microinjections of the alpha 2 agonist clonidine and of norepinephrine into the mPRF suppress the REM phase of sleep. Norepinephrine 92-106 Spi-C transcription factor (Spi-1/PU.1 related) Mus musculus 116-120 12010186-3 2002 The activity of COMT was estimated by the metabolism of noradrenaline to metanephrine (MN), both measured by high-performance liquid chromatography with electrochemical detection. Norepinephrine 56-69 catechol-O-methyltransferase Rattus norvegicus 16-20 7937350-0 1994 Modulation of the rat adrenal medulla norepinephrine secretion in a sodium-free medium by atrial natriuretic factor. Norepinephrine 38-52 natriuretic peptide A Rattus norvegicus 90-115 12102462-1 2002 Norepinephrine (NE), a vital neurotransmitter in both the central and peripheral nervous systems, is synthesized by dopamine beta-hydroxylase (DBH) through the oxidation of dopamine (DA) to NE. Norepinephrine 0-14 dopamine beta-hydroxylase Homo sapiens 116-141 12102462-1 2002 Norepinephrine (NE), a vital neurotransmitter in both the central and peripheral nervous systems, is synthesized by dopamine beta-hydroxylase (DBH) through the oxidation of dopamine (DA) to NE. Norepinephrine 0-14 dopamine beta-hydroxylase Homo sapiens 143-146 11857576-2 2002 The DBH gene, the locus that encodes the enzyme dopamine-beta-hydroxylase (DbetaH), seems to be an important candidate gene for association studies, since DbetaH catalyzes the conversion of dopamine to norepinephrine. Norepinephrine 202-216 dopamine beta-hydroxylase Homo sapiens 4-7 8306892-14 1993 Comparison of the number of neurons that differentiated from control and treated embryos showed that inhibition of dopamine beta-hydroxylase, the enzyme catalysing the conversion of dopamine to noradrenaline, during the neural plate stages reduced substantially subsequent neuronal differentiation. Norepinephrine 194-207 dopamine beta-hydroxylase (dopamine beta-monooxygenase) L homeolog Xenopus laevis 115-140 7511425-0 1993 Comparative effects of bradykinin and atrial natriuretic factor on neuronal and non-neuronal noradrenaline uptake in the central nervous system of the rat. Norepinephrine 93-106 natriuretic peptide A Rattus norvegicus 38-63 11857576-2 2002 The DBH gene, the locus that encodes the enzyme dopamine-beta-hydroxylase (DbetaH), seems to be an important candidate gene for association studies, since DbetaH catalyzes the conversion of dopamine to norepinephrine. Norepinephrine 202-216 dopamine beta-hydroxylase Homo sapiens 48-73 12057030-3 2002 Platelet I1 sites were quantified by p-[125I]iodoclonidine binding (0.5-15 nM) and displaced by moxonidine under a saturating concentration of norepinephrine to mask alpha2-adrenoceptors. Norepinephrine 143-157 nischarin Homo sapiens 9-11 8287409-7 1993 When noradrenaline was infused, c-fos mRNA was increased fivefold after 30, threefold after 60, and 3.8-fold after 90 min. Norepinephrine 5-18 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 32-37 8114953-3 1993 beta 1-adrenoceptors were activated by (-)-noradrenaline during beta 2-adrenoceptor blockade with 50 nmol/l ICI 118551. Norepinephrine 39-56 adrenoceptor beta 2 Homo sapiens 64-83 8114954-3 1993 Neuropeptide Y (NPY), its C-terminal fragment NPY (16-36) and peptide YY (PYY), at a concentration of 0.1 mumol/l all, potentiated the effect of noradrenaline, while [Leu31, Pro34]NPY (0.1 mumol/l) was inactive. Norepinephrine 145-158 peptide YY Rattus norvegicus 62-72 8114954-3 1993 Neuropeptide Y (NPY), its C-terminal fragment NPY (16-36) and peptide YY (PYY), at a concentration of 0.1 mumol/l all, potentiated the effect of noradrenaline, while [Leu31, Pro34]NPY (0.1 mumol/l) was inactive. Norepinephrine 145-158 peptide YY Rattus norvegicus 74-77 7904926-2 1993 Atrial natriuretic factor effects on neuronal noradrenaline release evoked by angiotensin II or III and high potassium solution plus angiotensin II and III in the rat hypothalamus were studied. Norepinephrine 46-59 natriuretic peptide A Rattus norvegicus 0-25 7904926-11 1993 Our results suggest that atrial natriuretic factor effects on noradrenaline release, evoked by angiotensin II, III and KCl, may be involved in the regulation of the central catecholamine pathways and sympathetic activity. Norepinephrine 62-75 natriuretic peptide A Rattus norvegicus 25-50 8263948-0 1993 Expression of c-fos and related genes in the rat heart in response to norepinephrine. Norepinephrine 70-84 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 14-19 8263948-1 1993 We have investigated the cellular and regional localization of Fos-like immunoreactivity (FLI) in the rat heart in response to the hypertrophic hormone norepinephrine (NE). Norepinephrine 152-166 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 63-66 12077484-3 2002 Norepinephrine (NE) induced AA-NAT and Per1, whereas its effect on Per2 was negligible. Norepinephrine 0-14 aralkylamine N-acetyltransferase Rattus norvegicus 28-34 8292267-1 1993 The sensitivity of rat anococcygeus muscle to noradrenaline (NA) was reduced following carbon disulphide (CS2) pretreatment. Norepinephrine 46-59 calsyntenin 2 Rattus norvegicus 106-109 8106008-0 1993 Norepinephrine-stimulated PI hydrolysis in oligodendrocytes is mediated by alpha 1A-adrenoceptors. Norepinephrine 0-14 calcium voltage-gated channel subunit alpha1 A Homo sapiens 75-83 8405122-5 1993 The inhibitory effect of these agents on the KCl-, norepinephrine-and phorbol 12,13-dibutyrate-induced contractions showed good correlations to the concentrations of the agents producing 50% inhibition (IC50) of cyclic GMP-inhibited cyclic nucleotide phosphodiesterase. Norepinephrine 51-65 phosphodiesterase 3A Rattus norvegicus 233-268 8500726-8 1993 Intravenous infusion of VIP and norepinephrine inhibited CCK-induced gallbladder contraction and these responses were abolished dose dependently by intravenous infusion of (4Cl-D-Phe6-Leu17)VIP and phentolamine, respectively. Norepinephrine 32-46 cholecystokinin Canis lupus familiaris 57-60 7688893-7 1993 Noradrenaline (10 microM) exhibited different actions on the various HVA current components: (1) it prolonged the activation kinetics of omega-CgTx-sensitive currents, (2) it depressed by about 20% the size of DHP-sensitive currents, and (3) it had little or no effects on the residual DHP- and omega-CgTx-resistant current although intracellularly applied guanosine 5"-O-(3-thiotriphosphate) (GTP-gamma-S) prolonged its activation time course. Norepinephrine 0-13 dihydropyrimidinase Rattus norvegicus 210-213 8491504-3 1993 Under control conditions, infusion of norepinephrine (10-40 ng/min per milliliter per minute of control renal blood flow) increased plasma renin activity and decreased renal blood flow progressively by approximately 10-75%. Norepinephrine 38-52 renin Canis lupus familiaris 139-144 11809916-9 2002 Furthermore, the peak epinephrine to norepinephrine ratio appearing between P7 and P10 in the normoxic offspring was absent in the hypoxic offspring. Norepinephrine 37-51 solute carrier family 10, member 7 Rattus norvegicus 76-86 11729636-4 2001 BAT thermogenesis by UCP-1, which has been studied most extensively, is controlled directly by sympathetic nerves principally through the beta-adrenergic action of norepinephrine. Norepinephrine 164-178 uncoupling protein 1 Homo sapiens 21-26 11782784-1 2001 Amylin (10(-10)M) induced relaxation of norepinephrine-precontracted rat aortic rings by more than 50%. Norepinephrine 40-54 islet amyloid polypeptide Rattus norvegicus 0-6 8402382-0 1993 Influence of atrial natriuretic factor on uptake, intracellular distribution, and release of norepinephrine in rat adrenal medulla. Norepinephrine 93-107 natriuretic peptide A Rattus norvegicus 13-38 8402382-3 1993 The aim of the present work was to investigate atrial natriuretic factor effects on the uptake, intracellular distribution, and release of norepinephrine in the rat adrenal medulla. Norepinephrine 139-153 natriuretic peptide A Rattus norvegicus 47-72 8402382-4 1993 Results showed that 100 nM atrial natriuretic factor induced a rapid increase of norepinephrine uptake during the first minute of the incubation period. Norepinephrine 81-95 natriuretic peptide A Rattus norvegicus 27-52 8402382-7 1993 Atrial natriuretic factor modified the intracellular distribution of the amine store: the granular fraction of norepinephrine increased, while the cytosolic fraction decreased. Norepinephrine 111-125 natriuretic peptide A Rattus norvegicus 0-25 8402382-9 1993 Furthermore, atrial natriuretic factor (10 nM) also reduced high potassium solution evoked secretion of norepinephrine. Norepinephrine 104-118 natriuretic peptide A Rattus norvegicus 13-38 8448583-10 1993 The permeability effect of PAF was only slightly enhanced by noradrenaline. Norepinephrine 61-74 PCNA clamp associated factor Rattus norvegicus 27-30 8380260-9 1993 We conclude, therefore, that the inhibitory effects of antecedent sympathetic release stimulation on cardiac sympathetic neurotransmission are mediated prejunctionally, probably via an inhibition of the neuronal release of norepinephrine by neuropeptide Y. Norepinephrine 223-237 neuropeptide Y Canis lupus familiaris 241-255 1281495-11 1992 However, norepinephrine produced a marked elevation of BDNF mRNA in astrocytes, an effect that was further enhanced by glutamate receptor agonists. Norepinephrine 9-23 brain-derived neurotrophic factor Rattus norvegicus 55-59 1472974-7 1992 NPY and the Y1-selective agonist, NPY[Leu31,Pro34], potentiated the constrictor responses to U46619 in both arterioles and responses to noradrenaline in the guinea-pig arterioles. Norepinephrine 136-149 pro-neuropeptide Y Cavia porcellus 0-3 1472974-7 1992 NPY and the Y1-selective agonist, NPY[Leu31,Pro34], potentiated the constrictor responses to U46619 in both arterioles and responses to noradrenaline in the guinea-pig arterioles. Norepinephrine 136-149 pro-neuropeptide Y Cavia porcellus 34-37 1438987-0 1992 Effects of atrial natriuretic factor on norepinephrine release in the rat hypothalamus. Norepinephrine 40-54 natriuretic peptide A Rattus norvegicus 11-36 1438987-1 1992 The effects of atrial natriuretic factor on the mechanisms involved in norepinephrine release were studied "in vitro" in slices of Wistar rat hypothalamus. Norepinephrine 71-85 natriuretic peptide A Rattus norvegicus 15-40 1355548-0 1992 Effects of platelet activating factor on contractions and 45Ca influx induced by noradrenaline and potassium in rat rubbed and intact aorta. Norepinephrine 81-94 PCNA clamp associated factor Rattus norvegicus 11-37 1355548-2 1992 In order to clarify the mechanism of hypotensive activity of platelet activating factor (PAF), the effects of this drug on blood pressure in anaesthetized normotensive rats, on KCl- and noradrenaline-induced 45Ca uptake and contractile responses in rat aorta rings with and without endothelium were studied. Norepinephrine 186-199 PCNA clamp associated factor Rattus norvegicus 61-87 1659528-7 1991 In addition, total (dephosphorylated) MEKA was observed to increase after a 6-h treatment with norepinephrine or (Bu)2 cAMP, an effect which was dependent upon new protein synthesis. Norepinephrine 95-109 phosducin Homo sapiens 38-42 1928327-2 1991 Prior exposure to PKC antagonists staurosporine (0.03 microM) and H-7 (10 microM) had relatively little effect on contractions to phorbol 12-myristate 13-acetate (PMA), while contractions to norepinephrine and KCl were greatly inhibited. Norepinephrine 191-205 protein kinase C, gamma Rattus norvegicus 18-21 1920125-1 1991 Neuropeptide Y (NPY) inhibits the release of noradrenaline (NA) or acetylcholine (ACh) from nerve terminals in the heart. Norepinephrine 45-58 neuropeptide Y Canis lupus familiaris 0-14 1920125-1 1991 Neuropeptide Y (NPY) inhibits the release of noradrenaline (NA) or acetylcholine (ACh) from nerve terminals in the heart. Norepinephrine 45-58 neuropeptide Y Canis lupus familiaris 16-19 1665390-5 1991 When two subsequent stimulations were performed in the same heart, adding exogenous noradrenaline before the second stimulation reduced NPY overflow on the contrary, and NPY decreased the overflow of noradrenaline. Norepinephrine 84-97 pro-neuropeptide Y Cavia porcellus 136-139 1665390-5 1991 When two subsequent stimulations were performed in the same heart, adding exogenous noradrenaline before the second stimulation reduced NPY overflow on the contrary, and NPY decreased the overflow of noradrenaline. Norepinephrine 200-213 pro-neuropeptide Y Cavia porcellus 170-173 11520626-11 2001 Knocking out the dopamine beta-hydroxylase gene results in fetal death, suggesting that noradrenaline is essential for survival. Norepinephrine 88-101 dopamine beta-hydroxylase Homo sapiens 17-42 11481155-0 2001 CSF norepinephrine concentrations in posttraumatic stress disorder. Norepinephrine 4-18 colony stimulating factor 2 Homo sapiens 0-3 11481155-2 2001 The goal of this study was to determine serial CSF norepinephrine levels in patients with PTSD. Norepinephrine 51-65 colony stimulating factor 2 Homo sapiens 47-50 1887900-5 1991 Norepinephrine infusion into the portal vein (1-5 micrograms.min-1.kg-1) caused Ppv to increase and the portal venous flow to decrease but did not significantly affect Phv. Norepinephrine 0-14 protein phosphatase 6, catalytic subunit Rattus norvegicus 80-83 1861148-6 1991 These observations contrast with those in another report in which we showed that bradykinin stimulation of either [32P]phosphatidic acid accumulation or noradrenaline release is not affected by R 59 022. Norepinephrine 153-166 kininogen 1 Bos taurus 81-91 1654511-7 1991 In the presence of the beta-adrenergic receptor antagonist propranolol, norepinephrine activated a background current with properties similar to those of the PKC-sensitive current. Norepinephrine 72-86 protein kinase C, gamma Rattus norvegicus 158-161 2054955-0 1991 Endothelin-1 enhances vasoconstrictor responses to sympathetic nerve stimulation and noradrenaline in the rabbit ear artery. Norepinephrine 85-98 endothelin-1 Oryctolagus cuniculus 0-12 11481155-4 2001 Thus the authors were able to determine hourly CSF norepinephrine concentrations under baseline (unstressed) conditions. Norepinephrine 51-65 colony stimulating factor 2 Homo sapiens 47-50 2054955-2 1991 In rabbit isolated perfused ear arteries denuded of endothelium, a low concentration of endothelin-1 (0.1 nmol/L) that had no direct vasoconstrictor action produced slowly developing enhancements of vasoconstrictor responses to noradrenaline and sympathetic nerve stimulation. Norepinephrine 228-241 endothelin-1 Oryctolagus cuniculus 88-100 11481155-6 2001 RESULTS: CSF norepinephrine concentrations were significantly higher in the men with PTSD than in the healthy men. Norepinephrine 13-27 colony stimulating factor 2 Homo sapiens 9-12 11481155-7 2001 Moreover, CSF norepinephrine levels strongly and positively correlated with the severity of PTSD symptoms. Norepinephrine 14-28 colony stimulating factor 2 Homo sapiens 10-13 11470013-10 2001 At the postsynaptic level, all currently used antihypertensive drugs have been found to attenuate alpha1-adrenergic functions either by interfering directly with intracellular mechanisms underlying alpha1-adrenergic functions or indirectly by decreasing the release of norepinephrine from peripheral sympathetic nerves. Norepinephrine 269-283 adrenoceptor alpha 1D Homo sapiens 98-104 11337745-2 2001 Since previous findings showed that some families with autistic children have a low level of serum dopamine beta-hydroxylase (DbetaH), which catalyzes the conversion of dopamine to norepinephrine, we examined the DBH gene as a candidate locus in families with two or more children with autism spectrum disorder using the affected sib-pair method. Norepinephrine 181-195 dopamine beta-hydroxylase Homo sapiens 99-124 11282402-1 2001 Dopamine beta-hydroxylase (DBH) catalyzes the beta-hydroxylation of dopamine to norepinephrine. Norepinephrine 80-94 dopamine beta-hydroxylase Homo sapiens 0-25 11282402-1 2001 Dopamine beta-hydroxylase (DBH) catalyzes the beta-hydroxylation of dopamine to norepinephrine. Norepinephrine 80-94 dopamine beta-hydroxylase Homo sapiens 27-30 11306173-5 2001 When HB2 cells were stimulated by norepinephrine, the VEGF mRNA level increased without a change in that of VEGF-B, while the VEGF-C mRNA level decreased. Norepinephrine 34-48 vascular endothelial growth factor B Mus musculus 108-114 12369708-6 2001 BDNF enhanced norepinephrine turnover and increased uncoupling protein-1 mRNA expression in the interscapular brown adipose tissue. Norepinephrine 14-28 brain derived neurotrophic factor Mus musculus 0-4 1999358-8 1991 These findings indicate that the renin-angiotensin system prevents exaggerated renal vascular responses to chronic norepinephrine stimulation by preserving renal perfusion pressure. Norepinephrine 115-129 renin Canis lupus familiaris 33-38 2257445-2 1990 The role of protein kinase C (PKC) in mediating enhanced contractile responses of aortae and mesenteric arteries from male rats with 12-14 week streptozotocin-induced diabetes to noradrenaline (NA) was investigated using the PKC activator, phorbol 12,13-dibutyrate (PDB), and the PKC inhibitor, staurosporine. Norepinephrine 179-192 protein kinase C, gamma Rattus norvegicus 30-33 1697888-4 1990 The effect of VIP was inhibited by addition of norepinephrine or of nitrendipine or by exposing the cells to "unexpected" white light. Norepinephrine 47-61 vasoactive intestinal peptide Gallus gallus 14-17 11752890-2 2001 IL-1 and LPS are known to affect cerebral neurotransmission involving norepinephrine and serotonin, both of which have been implicated in feeding behavior and in the pharmacotherapy of depression in man. Norepinephrine 70-84 interleukin 1 alpha Homo sapiens 0-4 1697381-7 1990 Inosine in combination with ADA antagonized the noradrenaline-induced positive inotropic effect and the increase in cardiac output. Norepinephrine 48-61 adenosine deaminase Rattus norvegicus 28-31 1697381-9 1990 bolus injection of noradrenaline in rats pretreated with inosine and ADA did not increase blood pressure and total peripheral resistance. Norepinephrine 19-32 adenosine deaminase Rattus norvegicus 69-72 2167733-4 1990 In superfused vas deferens preparations, NPY (0.3 microM) inhibited the stimulus-evoked overflow of both ATP and [3H]-noradrenaline ([3H]-NA) at 2 Hz, but only the stimulus-evoked release of [3H]-NA at 20 Hz. Norepinephrine 118-131 pro-neuropeptide Y Cavia porcellus 41-44 11516836-10 2001 These results indicate that arylalkylamine N-acetyltransferase mRNA in ganglionectomized rats is not induced by circulating catecholamines and may be caused by both a centrally originated norepinephrine, as already suggested, and other non-adrenergic transmitter(s). Norepinephrine 188-202 aralkylamine N-acetyltransferase Rattus norvegicus 28-62 11516836-11 2001 In conclusion, this work shows that norepinephrine drives the nocturnal increase of arylalkylamine N-acetyltransferase gene expression both in the superficial and deep pineal and strongly suggests that other neurotransmitters are involved in day-time inhibition and night-time stimulation of pineal metabolism. Norepinephrine 36-50 aralkylamine N-acetyltransferase Rattus norvegicus 84-118 11080198-0 2000 Neuropeptide Y cotransmission with norepinephrine in the sympathetic nerve-macrophage interplay. Norepinephrine 35-49 neuropeptide Y Homo sapiens 0-14 11080198-2 2000 To study the nerve-macrophage communication, a superfusion method was used to investigate cotransmission of neuropeptide Y (NPY) with norepinephrine (NE), with interleukin (IL)-6 secretion used as the macrophage read-out parameter. Norepinephrine 134-148 neuropeptide Y Homo sapiens 124-127 11055982-5 2000 In mouse myocyte cultures, triiodothyronine (T3), norepinephrine (NE) through a beta-adrenergic receptor, and leukemia inhibitory factor induced hypertrophy by a 20% to 30% increase in [(3)H]phenylalanine-labeled protein content. Norepinephrine 50-64 leukemia inhibitory factor Mus musculus 80-136 10971815-13 2000 infusion of E2, which induces a preovulatory surge-like release of LH, stimulates brain noradrenaline activity; this enhanced activity likely involves an ER-mediated process and is reflected by hypothalamic noradrenaline release and locus coeruleus TH mRNA expression. Norepinephrine 88-101 tyrosine hydroxylase Macaca mulatta 249-251 11081224-2 2000 Results of the biochemical analysis of the MAO A activity with serotonin or noradrenaline as substrates revealed a seasonal dependence of the substrate specific changes of this enzyme activity in hibernating animals. Norepinephrine 76-89 monoamine oxidase A Homo sapiens 43-48 10961962-2 2000 Neuropeptide Y (NPY), which is costored and released with norepinephrine (NE) during sympathetic activity, is a potent vasoconstrictor with a relatively long half-life. Norepinephrine 58-72 neuropeptide Y Homo sapiens 0-14 10961962-2 2000 Neuropeptide Y (NPY), which is costored and released with norepinephrine (NE) during sympathetic activity, is a potent vasoconstrictor with a relatively long half-life. Norepinephrine 58-72 neuropeptide Y Homo sapiens 16-19 10878345-1 2000 The neurotransmitter norepinephrine (NE) binds to the beta 2-adrenergic receptor (beta 2AR) expressed on various immune cells to influence cell homing, proliferation, and function. Norepinephrine 21-35 adrenergic receptor, beta 2 Mus musculus 54-80 1973424-9 1990 The present study demonstrates that neuropeptide Y is co-released with noradrenaline from sympathetic nerve fibers during haemorrhage. Norepinephrine 71-84 neuropeptide Y Canis lupus familiaris 36-50 1973424-10 1990 Since the release of neuropeptide Y appeared to follow a similar time course to that of noradrenaline release, the present observations suggest that haemorrhagic hypotension enhances both neuropeptide Y and noradrenaline release presumably through a common releasing mechanism. Norepinephrine 88-101 neuropeptide Y Canis lupus familiaris 188-202 1973424-11 1990 These results also indicate that, in peripheral sympathetic nerves but not in the adrenal gland, neuropeptide Y release is also modulated presynaptically by the inhibitory alpha 2-adrenoceptors in conjunction with the noradrenaline release. Norepinephrine 218-231 neuropeptide Y Canis lupus familiaris 97-111 2185153-8 1990 Insulin infusion (1.0 milliunits/kg/min) for 7 days during simultaneous infusion of norepinephrine did not further increase mean arterial pressure, which averaged 101 +/- 3 during norepinephrine and 98 +/- 2 mm Hg during insulin plus norepinephrine infusion. Norepinephrine 84-98 insulin Canis lupus familiaris 0-7 10878345-1 2000 The neurotransmitter norepinephrine (NE) binds to the beta 2-adrenergic receptor (beta 2AR) expressed on various immune cells to influence cell homing, proliferation, and function. Norepinephrine 21-35 adrenergic receptor, beta 2 Mus musculus 82-90 10826917-8 2000 Other MPO systems inactivating LADH were (a) MPO/H2O2/chlorpromazine; (b) MPO/H2O2/monophenolic systems, including L-tyrosine, serotonin and acetaminophen and (c) MPO/H2O2/di- and polyphenolic systems, including norepinephrine, catechol, nordihydroguaiaretic acid, caffeic acid, quercetin and catechin. Norepinephrine 212-226 myeloperoxidase Sus scrofa 6-9 10998536-2 2000 Nociceptin inhibits the electrically or K(+)-evoked noradrenaline, dopamine, serotonin, and glutamate release in brain slices from guinea-pig, rat, and mouse. Norepinephrine 52-65 prepronociceptin Rattus norvegicus 0-10 10866041-6 2000 Adipocytes isolated from AFABP-KO and WT mice fed high- or low-fat diets exhibited similar rates of basal and norepinephrine-stimulated lipolysis and insulin-stimulated rates of glucose conversion to fatty acids and glyceride-glycerol. Norepinephrine 110-124 fatty acid binding protein 4, adipocyte Mus musculus 25-30 10737636-8 2000 PNMT is the enzyme that converts noradrenaline to adrenaline and is not expressed in noradrenaline-secreting cells. Norepinephrine 33-46 phenylethanolamine-N-methyltransferase Rattus norvegicus 0-4 2348052-3 1990 50 nM Neuropeptide Y increased the amplitude of constriction caused by noradrenaline or brief trains of nerve stimulation, showing that it potentiated the effects of vasoconstrictors as it does in other arteries. Norepinephrine 71-84 pro-neuropeptide Y Cavia porcellus 6-20 2326502-1 1990 Neuropeptide Y (NPY) coexists with noradrenaline (NA) in many peripheral sympathetic nerves. Norepinephrine 35-48 pro-neuropeptide Y Cavia porcellus 0-14 2326502-1 1990 Neuropeptide Y (NPY) coexists with noradrenaline (NA) in many peripheral sympathetic nerves. Norepinephrine 35-48 pro-neuropeptide Y Cavia porcellus 16-19 10762326-2 2000 This rhythm involves the transcriptional regulation of the AANAT by two norepinephrine (NE)-inducible transcription factors, e.g. the activator pCREB (phosphorylated Ca2+/cAMP-response element binding protein) and the inhibitor ICER (inducible cAMP early repressor). Norepinephrine 72-86 arylalkylamine N-acetyltransferase Mus musculus 59-64 10678267-7 2000 During MST-1, norepinephrine increased by 461 +/-165 pmol/L (mean +/- SEM) and epinephrine by 218 +/- 76 pmol/L. Norepinephrine 14-28 macrophage stimulating 1 Homo sapiens 7-12 2328760-4 1990 In aorta, ISF-2405 inhibited the increase in [Ca2+]cyt and muscle tension caused by norepinephrine. Norepinephrine 84-98 carbonic anhydrase 2 Canis lupus familiaris 46-49 2328760-5 1990 A Ca2+ channel blocker, verapamil, inhibited the norepinephrine-stimulated increase in [Ca2+]cyt more potently than it inhibited the increase in muscle tension, and ISF-2405 inhibited the verapamil-resistant part of the contraction. Norepinephrine 49-63 carbonic anhydrase 2 Canis lupus familiaris 2-5 2328760-5 1990 A Ca2+ channel blocker, verapamil, inhibited the norepinephrine-stimulated increase in [Ca2+]cyt more potently than it inhibited the increase in muscle tension, and ISF-2405 inhibited the verapamil-resistant part of the contraction. Norepinephrine 49-63 carbonic anhydrase 2 Canis lupus familiaris 88-91 2328760-6 1990 In Ca2(+)-free solution, norepinephrine induced transient increases in [Ca2+]cyt and muscle tension. Norepinephrine 25-39 carbonic anhydrase 2 Canis lupus familiaris 3-6 2328760-6 1990 In Ca2(+)-free solution, norepinephrine induced transient increases in [Ca2+]cyt and muscle tension. Norepinephrine 25-39 carbonic anhydrase 2 Canis lupus familiaris 72-75 1969352-1 1990 Phosphorylation of the neuron-specific substrate of protein kinase C (PKC), B-50 (GAP-43), was studied parallel with noradrenaline release in rat brain synaptosomes. Norepinephrine 117-130 protein kinase C, gamma Rattus norvegicus 52-68 1969352-4 1990 To investigate the involvement of PKC-mediated B-50 phosphorylation in noradrenaline release, we applied a variety of kinase inhibitors. Norepinephrine 71-84 protein kinase C, gamma Rattus norvegicus 34-37 1969403-9 1990 The percentage of cells in which PCNA could be detected was higher in the norepinephrine and norepinephrine plus propranolol groups. Norepinephrine 74-88 proliferating cell nuclear antigen Rattus norvegicus 33-37 1969403-9 1990 The percentage of cells in which PCNA could be detected was higher in the norepinephrine and norepinephrine plus propranolol groups. Norepinephrine 93-107 proliferating cell nuclear antigen Rattus norvegicus 33-37 2282373-3 1990 These effects of angiotensin II were reversed when tissues were pretreated with staurosporine (50 nM), an inhibitor of protein kinase C. The amplification of the alpha-adrenoceptor-mediated vasoconstrictor effects of thrombin and norepinephrine by angiotensin II were also reversed by pretreatment with staurosporine. Norepinephrine 230-244 prothrombin Oryctolagus cuniculus 217-225 10670458-5 2000 The promotion of memory consolidation by noradrenaline or isoprenaline at low doses was attributable to beta3-adrenoceptors and at medium doses to beta2-adrenoceptors. Norepinephrine 41-54 basic helix-loop-helix family member e22 Gallus gallus 104-109 23531135-6 2000 Inhibitors of MAO A are clinically useful to treat anxiety and depression since they are expected to increase both noradrenalin and serotonin levels in the brain. Norepinephrine 115-127 monoamine oxidase A Homo sapiens 14-19 2153070-1 1990 Inhibition of monoamine oxidase B (MAO B) by selective inhibitors pargyline and L-deprenyl increases dopamine (DA) and norepinephrine (NE) concentrations in nucleus accumbens (NACB) and is associated with reduction in cold water restraint-induced gastric mucosal injury, inhibition of basal gastric acid output, and regional gastric mucosal blood flow. Norepinephrine 119-133 monoamine oxidase B Rattus norvegicus 14-33 2153070-1 1990 Inhibition of monoamine oxidase B (MAO B) by selective inhibitors pargyline and L-deprenyl increases dopamine (DA) and norepinephrine (NE) concentrations in nucleus accumbens (NACB) and is associated with reduction in cold water restraint-induced gastric mucosal injury, inhibition of basal gastric acid output, and regional gastric mucosal blood flow. Norepinephrine 119-133 monoamine oxidase B Rattus norvegicus 35-40 2182573-6 1990 Both norepinephrine and epinephrine containing cells of the adrenal medulla exhibited a strong reaction for PLI. Norepinephrine 5-19 serpin family F member 2 Homo sapiens 108-111 2314485-2 1990 PAF caused a dose-dependent vasodilation of norepinephrine-contracted mesenteric vascular bed, which was sensitive to CV-3988, a PAF antagonist, but insensitive to tetrodotoxin, atropine, propranolol and indomethacin. Norepinephrine 44-58 PCNA clamp associated factor Rattus norvegicus 0-3 2314485-2 1990 PAF caused a dose-dependent vasodilation of norepinephrine-contracted mesenteric vascular bed, which was sensitive to CV-3988, a PAF antagonist, but insensitive to tetrodotoxin, atropine, propranolol and indomethacin. Norepinephrine 44-58 PCNA clamp associated factor Rattus norvegicus 129-132 10598792-8 1999 Noradrenaline-induced [3H]IP1 accumulation was also inhibited by alpha1-antagonists. Norepinephrine 0-13 inhibitor of nuclear factor kappa B kinase regulatory subunit gamma Homo sapiens 26-29 10598792-10 1999 The accumulation of [3H]IP1 in response to 100 microM noradrenaline was not significantly affected by raising the extracellular Ca2+ concentration from 1.3 to 4 mM. Norepinephrine 54-67 inhibitor of nuclear factor kappa B kinase regulatory subunit gamma Homo sapiens 24-27 10598792-12 1999 Pretreatment with chloroethylclonidine (10 microM, 15 min) abolished noradrenaline-induced [3H]IP1 accumulation and Ca2+ mobilisation. Norepinephrine 69-82 inhibitor of nuclear factor kappa B kinase regulatory subunit gamma Homo sapiens 95-98 10535767-1 1999 Phosphorylation of cyclic AMP response element binding protein (CREB) at amino acid serine 133 appears as an important link between the norepinephrine (NE)-induced activation of second messenger systems and the stimulation of melatonin biosynthesis. Norepinephrine 136-150 cAMP responsive element binding protein 1 Rattus norvegicus 19-62 34973951-8 2022 Responses to intra-renal administration of adrenergic agonists including noradrenaline (NA), phenylephrine (PE), methoxamine (ME), and angiotensin-II (ANG-II) were larger in diabetic WKY, but significantly blunted with adiponectin treatment in diabetic WKYs to 35-40%, and further reduced by 65-70% in combination with pioglitazone. Norepinephrine 73-86 adiponectin, C1Q and collagen domain containing Rattus norvegicus 219-230 34958827-9 2022 Norepinephrine (NE), PMA and m-3M3FBS were used to activate alpha-1 adrenergic signaling. Norepinephrine 0-14 UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus 60-67 34912235-0 2021 Neurogenic Hypertension Mediated Mitochondrial Abnormality Leads to Cardiomyopathy: Contribution of UPRmt and Norepinephrine-miR- 18a-5p-HIF-1alpha Axis. Norepinephrine 110-124 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 137-147 10535767-1 1999 Phosphorylation of cyclic AMP response element binding protein (CREB) at amino acid serine 133 appears as an important link between the norepinephrine (NE)-induced activation of second messenger systems and the stimulation of melatonin biosynthesis. Norepinephrine 136-150 cAMP responsive element binding protein 1 Rattus norvegicus 64-68 10629875-5 1999 And norepinephrine enhanced the effect of neuropeptide Y on lung vascular permeability. Norepinephrine 4-18 neuropeptide Y Homo sapiens 42-56 34062902-5 2021 We utilized cell lines overexpressing alpha1A-, alpha1B- or alpha1D-ARs to investigate the effects of the antidepressants imipramine (IMI), desipramine (DMI), mianserin (MIA), reboxetine (REB), citalopram (CIT) and fluoxetine (FLU) on noradrenaline-induced second messenger generation by those receptors. Norepinephrine 235-248 alpha-1-B glycoprotein Homo sapiens 48-55 10465291-2 1999 In preadipocytes, norepinephrine (NE) increased cAMP levels but the beta3-agonists BRL-37344 and CGP-12177 did not; in contrast, when the cells had differentiated into mature brown adipocytes, a large cAMP response to the beta3-agonists had emerged and was now double that to NE (although the affinity of NE had increased 10-fold). Norepinephrine 18-32 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 222-227 34104992-3 2021 One such mechanism involves the direct inhibition by corticosteroid hormones of monoamine transport mediated by the "uptake2" transporter, organic cation transporter 3 (OCT3), a high-capacity, low-affinity transporter for norepinephrine, epinephrine, dopamine, serotonin, and histamine. Norepinephrine 222-236 OCTN3 Homo sapiens 169-173 35580792-9 2022 When activated ex vivo, secretion of IL-17A and IL-22 by THT-KO T-lymphocytes was also found to be reduced, but could be partially rescued with supplementation of norepinephrine specifically. Norepinephrine 163-177 interleukin 17A Homo sapiens 37-43 35580792-9 2022 When activated ex vivo, secretion of IL-17A and IL-22 by THT-KO T-lymphocytes was also found to be reduced, but could be partially rescued with supplementation of norepinephrine specifically. Norepinephrine 163-177 interleukin 22 Homo sapiens 48-53 10475560-2 1999 The study focused on the autonomic messengers neuropeptide Y (NPY), tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of noradrenaline (NA), and vasoactive intestinal polypeptide (VIP). Norepinephrine 140-153 neuropeptide Y Homo sapiens 46-60 10475560-2 1999 The study focused on the autonomic messengers neuropeptide Y (NPY), tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of noradrenaline (NA), and vasoactive intestinal polypeptide (VIP). Norepinephrine 140-153 neuropeptide Y Homo sapiens 62-65 10381895-7 1999 Pulmonary vasopressor responses to endothelin-1 (ET-1), angiotensin II, and ventilatory hypoxia were reduced significantly in animals transfected with the eNOS gene, whereas pressor responses to norepinephrine and U46619 were not changed. Norepinephrine 195-209 nitric oxide synthase 3, endothelial cell Mus musculus 155-159 35264016-3 2022 Given that an increase in cardiac mass is often caused by adrenergic hyperactivity, we hypothesized that VAChT KDHOM mice might have an increase in cardiac norepinephrine (NE) levels. Norepinephrine 156-170 solute carrier family 18 (vesicular monoamine), member 3 Mus musculus 105-110 35054851-2 2022 This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA. Norepinephrine 72-86 adrenoceptor beta 2 Homo sapiens 44-64 35054851-2 2022 This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA. Norepinephrine 72-86 interleukin 17A Homo sapiens 110-124 35054851-2 2022 This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA. Norepinephrine 72-86 interleukin 17A Homo sapiens 126-131 10443582-1 1999 Alpha1-adrenoceptors are one of three subfamilies of receptors (alpha1, alpha2, beta) mediating responses to adrenaline and noradrenaline. Norepinephrine 124-137 adrenoceptor alpha 1D Homo sapiens 0-6 35054851-2 2022 This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA. Norepinephrine 72-86 adrenoceptor beta 2 Homo sapiens 374-394 35054851-2 2022 This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA. Norepinephrine 352-366 adrenoceptor beta 2 Homo sapiens 44-64 35054851-2 2022 This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA. Norepinephrine 352-366 interleukin 17A Homo sapiens 110-124 35054851-2 2022 This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA. Norepinephrine 352-366 interleukin 17A Homo sapiens 126-131 35054851-3 2022 Norepinephrine suppressed IL-17 and IFN-gamma production by the anti-CD3/anti-CD28-microbead-stimulated CD4+ T cells in both groups. Norepinephrine 0-14 interleukin 17A Homo sapiens 26-31 35054851-4 2022 Blockade of the beta2-adrenoreceptor with the specific antagonist ICI 118.551 enhanced norepinephrine-mediated IL-17 suppression but decreased its inhibitory effect on IFN-gamma production in MS patients. Norepinephrine 87-101 interleukin 17A Homo sapiens 111-116 35054851-8 2022 These data illustrate the inhibitory effect of norepinephrine on IL-17 and IFN-gamma production by CD4+ T cells in MS. Norepinephrine 47-61 interleukin 17A Homo sapiens 65-70 10443582-1 1999 Alpha1-adrenoceptors are one of three subfamilies of receptors (alpha1, alpha2, beta) mediating responses to adrenaline and noradrenaline. Norepinephrine 124-137 adrenoceptor alpha 1D Homo sapiens 64-70 35054851-9 2022 The inhibitory effect of norepinephrine on IFN-gamma production by CD4+ T cells in MS could be mediated via beta2-adrenoreceptor activation. Norepinephrine 25-39 adrenoceptor beta 2 Homo sapiens 108-128 10224140-10 1999 Acidic metabolites of neurotransmitters derived from dopamine, epinephrine, norepinephrine, and serotonin inhibited the uptake of estrone sulfate via OAT3. Norepinephrine 76-90 solute carrier family 22 member 8 Rattus norvegicus 150-154 2577226-0 1989 The interaction of cholecystokinin and its fragments with norepinephrine in the circulatory system of diabetic rats. Norepinephrine 58-72 cholecystokinin Rattus norvegicus 19-34 2577226-1 1989 The interaction of cholecystokinin (CCK-33) and its fragments, C-terminal octapeptide (CCK-8) and C-terminal tetrapeptide (CCK-4) with norepinephrine (NE) was studied in rats with streptozotocin (STZ)-induced diabetes. Norepinephrine 135-149 cholecystokinin Rattus norvegicus 19-34 9878889-0 1999 Accumulation of 3,4-dihydroxyphenylglycolaldehyde, the neurotoxic monoamine oxidase A metabolite of norepinephrine, in locus ceruleus cell bodies in Alzheimer"s disease: mechanism of neuron death. Norepinephrine 100-114 monoamine oxidase A Homo sapiens 66-85 2528911-7 1989 The studies show that insulin-induced hypoglycemia was associated with a rise in plasma cortisol, beta-endorphin, epinephrine, norepinephrine, and glucagon. Norepinephrine 127-141 insulin Canis lupus familiaris 22-29 2555449-0 1989 A molecular modelling study of the interaction of noradrenaline with the beta 2-adrenergic receptor. Norepinephrine 50-63 adrenoceptor beta 2 Homo sapiens 73-99 2776842-4 1989 Pretreating the coronary system of these hearts with NPY caused a marked potentiation of the vasocontractile effect of noradrenaline, displacing its dose-response curve to the left in a non-parallel fashion. Norepinephrine 119-132 neuropeptide Y Canis lupus familiaris 53-56 9878889-1 1999 3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the neurotoxic monoamine oxidase A (MAO-A) metabolite of norepinephrine (NE). Norepinephrine 104-118 monoamine oxidase A Homo sapiens 62-81 9878889-1 1999 3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the neurotoxic monoamine oxidase A (MAO-A) metabolite of norepinephrine (NE). Norepinephrine 104-118 monoamine oxidase A Homo sapiens 83-88 10075201-3 1999 The primary antibody used recognized DBH, the key enzyme in the conversion of dopamine to noradrenaline. Norepinephrine 90-103 dopamine beta-hydroxylase Homo sapiens 37-40 2752979-11 1989 In isolated helical strips of rat aorta, PTHrp and PTH relaxed norepinephrine-contracted tissues in a concentration-dependent fashion. Norepinephrine 63-77 parathyroid hormone-like hormone Rattus norvegicus 41-46 2547929-3 1989 Synthetic rat ANF (99-126) inhibited K+-induced norepinephrine and dopamine release, as measured by high-performance liquid chromatography, in a concentration-dependent manner over the concentration range of 10(-11) to 10(-8) M. ANF stimulated intracellular cGMP accumulation, as measured by specific radioimmunoassay, in a concentration-dependent manner over the same concentration range. Norepinephrine 48-62 natriuretic peptide A Rattus norvegicus 14-17 10075201-9 1999 CONCLUSIONS: The localization of DBH-related immunoreactivity is generally consistent with the known physiological roles of noradrenaline. Norepinephrine 124-137 dopamine beta-hydroxylase Homo sapiens 33-36 10071761-3 1999 Recent studies have shown that the sympathetic nervous system, via norepinephrine (beta-adrenoceptors) and cAMP, as well as thyroid hormones and PPAR gamma ligands seem to be major regulators of UCP expression. Norepinephrine 67-81 uncoupling protein 1 Homo sapiens 195-198 10467023-2 1999 Addition of beta-adrenoceptor agonists produced a concentration-dependent relaxation of noradrenaline-precontracted tissues, a rank order potency being isoproterenol (1) > salbutamol (0.95) > selective beta(3)-adrenoceptor agonists, CL 316243 (0.85), and BRL 37344 (0. Norepinephrine 88-101 adrenoceptor beta 3 Canis lupus familiaris 208-228 10098976-3 1999 In this study, further characterization of p53LMAC01 cell line was investigated according to cell growth and differentiation, and especially focused into the changes of cell feature, actin filaments" formation, and changes of intracellular calcium concentrations to sympathetic nerve transmitter, norepinephrine. Norepinephrine 297-311 transformation related protein 53, pseudogene Mus musculus 43-46 2557609-3 1989 Adrenergic agonists increased the cAMP levels in EPA in the order of potency characteristic for beta 2-AR: isoproterenol greater than epinephrine greater than norepinephrine. Norepinephrine 159-173 adrenoceptor beta 2 Homo sapiens 96-105 9881594-4 1998 Comparison of the effects of anti-B-50 antibodies on glutamate and noradrenaline release from permeated synaptosomes revealed two major differences. Norepinephrine 67-80 growth associated protein 43 Homo sapiens 34-38 2537155-2 1989 Melittin, a polypeptide found in honeybee venom and a known activator of phospholipase A2, induced transient, endothelium-dependent relaxations of rat thoracic aortae contracted with norepinephrine. Norepinephrine 183-197 melittin Apis mellifera 0-8 2481466-8 1989 These observations indicate that NPY and GAL are distributed differently in LC neurons from noradrenaline and DBH. Norepinephrine 92-105 galanin and GMAP prepropeptide Homo sapiens 41-44 2677641-5 1989 Caffeine and norepinephrine release Ca2+ from this store to induce a transient contraction. Norepinephrine 13-27 carbonic anhydrase 2 Homo sapiens 36-39 2634963-1 1989 The effects of L-adrenaline and L-noradrenaline on human lecithin: cholesterol acyltransferase (LCAT) activity were investigated in vitro. Norepinephrine 32-47 lecithin-cholesterol acyltransferase Homo sapiens 96-100 10197057-6 1998 An alternative strategy for directly modulating sympathetic nerve function is to inhibit the biosynthesis of norepinephrine (NE) via inhibition of dopamine-beta-hydroxylase (DBH), the enzyme which catalyzes the conversion of dopamine (DA) to NE in sympathetic nerves. Norepinephrine 109-123 dopamine beta-hydroxylase Homo sapiens 147-172 10197057-6 1998 An alternative strategy for directly modulating sympathetic nerve function is to inhibit the biosynthesis of norepinephrine (NE) via inhibition of dopamine-beta-hydroxylase (DBH), the enzyme which catalyzes the conversion of dopamine (DA) to NE in sympathetic nerves. Norepinephrine 109-123 dopamine beta-hydroxylase Homo sapiens 174-177 9828226-0 1998 Connexin 32 gap junctions enhance stimulation of glucose output by glucagon and noradrenaline in mouse liver. Norepinephrine 80-93 gap junction protein, beta 1 Mus musculus 0-11 9886882-1 1998 OBJECTIVES: Recently, in rat aortae, two putative digitalis-like factors, marinobufagenin and ouabain, were shown to interact with alpha-1 (sarcolemma) and alpha-3 (nerve endings) subunits of the sodium pump, respectively, and elicit vasoconstriction via inhibition of the Na+,K+-pump in vascular smooth muscle or norepinephrine release. Norepinephrine 314-328 adrenoceptor alpha 1D Homo sapiens 131-138 9819240-11 1998 In this same population of dorsal horn neurons, norepinephrine has a direct alpha1-mediated excitatory effect. Norepinephrine 48-62 adrenoceptor alpha 1D Homo sapiens 76-82 9763638-0 1998 Effects of noradrenaline on intracellular pH in acutely dissociated adult rat hippocampal CA1 neurones. Norepinephrine 11-24 carbonic anhydrase 1 Rattus norvegicus 90-93 9763638-7 1998 Noradrenaline evoked a concentration-dependent and sustained rise in steady-state pHi and increased rates of pHi recovery from imposed intracellular acid loads. Norepinephrine 0-13 glucose-6-phosphate isomerase Rattus norvegicus 82-85 9763638-7 1998 Noradrenaline evoked a concentration-dependent and sustained rise in steady-state pHi and increased rates of pHi recovery from imposed intracellular acid loads. Norepinephrine 0-13 glucose-6-phosphate isomerase Rattus norvegicus 109-112 2473320-1 1989 Addition of endothelin-1 (ET-1) to primary cultures of bovine adrenal chromaffin cells causes a significant enhancement of norepinephrine and epinephrine efflux, with an EC50 of about 1 nM. Norepinephrine 123-137 endothelin 1 Bos taurus 12-24 9763638-8 1998 The effects of noradrenaline were not dependent upon the presence of external HCO3- but were blocked by substituting external Na+ with N-methyl-D-glucamine, suggesting that noradrenaline acts to increase steady-state pHi by increasing the activity of the Na+-H+ exchanger. Norepinephrine 15-28 glucose-6-phosphate isomerase Rattus norvegicus 217-220 2473320-1 1989 Addition of endothelin-1 (ET-1) to primary cultures of bovine adrenal chromaffin cells causes a significant enhancement of norepinephrine and epinephrine efflux, with an EC50 of about 1 nM. Norepinephrine 123-137 endothelin 1 Bos taurus 26-30 2473320-3 1989 The amounts of noradrenaline and adrenaline released by ET-1 was smaller than the release elicited by maximally effective concentrations of bradykinin or prostaglandin E2. Norepinephrine 15-28 endothelin 1 Bos taurus 56-60 3241276-2 1988 In the pithed rat the increase in diastolic blood pressure elicited by Ang II consisted of an interaction with the sympathetic nervous system involving presynaptically released noradrenaline and of a direct stimulation of postsynaptic Ang II-receptors on vascular smooth muscle. Norepinephrine 177-190 angiogenin Rattus norvegicus 71-74 9763638-8 1998 The effects of noradrenaline were not dependent upon the presence of external HCO3- but were blocked by substituting external Na+ with N-methyl-D-glucamine, suggesting that noradrenaline acts to increase steady-state pHi by increasing the activity of the Na+-H+ exchanger. Norepinephrine 173-186 glucose-6-phosphate isomerase Rattus norvegicus 217-220 9763638-10 1998 The effects of noradrenaline on steady-state pHi and on rates of pHi recovery from imposed acid loads were mimicked by beta1- and beta2-, but not alpha-, adrenoceptor agonists. Norepinephrine 15-28 glucose-6-phosphate isomerase Rattus norvegicus 45-48 9763638-10 1998 The effects of noradrenaline on steady-state pHi and on rates of pHi recovery from imposed acid loads were mimicked by beta1- and beta2-, but not alpha-, adrenoceptor agonists. Norepinephrine 15-28 glucose-6-phosphate isomerase Rattus norvegicus 65-68 9763638-11 1998 The beta-adrenoceptor antagonist propranolol blocked the ability of noradrenaline to increase both steady-state pHi and rates of pHi recovery from acid loads. Norepinephrine 68-81 glucose-6-phosphate isomerase Rattus norvegicus 112-115 9763638-11 1998 The beta-adrenoceptor antagonist propranolol blocked the ability of noradrenaline to increase both steady-state pHi and rates of pHi recovery from acid loads. Norepinephrine 68-81 glucose-6-phosphate isomerase Rattus norvegicus 129-132 9763638-13 1998 The effects of noradrenaline on steady-state pHi and on pHi recovery rates following acid loads were not dependent on changes in [Ca2+]i. Norepinephrine 15-28 glucose-6-phosphate isomerase Rattus norvegicus 45-48 9763638-13 1998 The effects of noradrenaline on steady-state pHi and on pHi recovery rates following acid loads were not dependent on changes in [Ca2+]i. Norepinephrine 15-28 glucose-6-phosphate isomerase Rattus norvegicus 56-59 9724817-3 1998 We now show that the primate ovary expresses both the genes encoding TH and dopamine beta-hydroxylase (DBH), the key enzymes in norepinephrine (NE) biosynthesis. Norepinephrine 128-142 dopamine beta-hydroxylase Homo sapiens 76-101 9724817-3 1998 We now show that the primate ovary expresses both the genes encoding TH and dopamine beta-hydroxylase (DBH), the key enzymes in norepinephrine (NE) biosynthesis. Norepinephrine 128-142 dopamine beta-hydroxylase Homo sapiens 103-106 9648849-1 1998 Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline and is selectively expressed in noradrenergic and adrenergic neurons in the nervous system. Norepinephrine 72-85 dopamine beta-hydroxylase Homo sapiens 0-25 9648849-1 1998 Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline and is selectively expressed in noradrenergic and adrenergic neurons in the nervous system. Norepinephrine 72-85 dopamine beta-hydroxylase Homo sapiens 27-30 9648875-10 1998 These results suggest that norepinephrine terminals regulate extracellular dopamine concentrations in the medial prefrontal cortex and to a lesser extent in the nucleus accumbens shell through the uptake of dopamine by the norepinephrine transporter. Norepinephrine 27-41 solute carrier family 6 member 2 Rattus norvegicus 223-249 9608581-4 1998 NPY is a 36 amino acid peptide neurotransmitter located in sympathetic and nonsympathetic nerve fibers, as well as in brain structures such as the locus coeruleus, where it is colocalized with norepinephrine. Norepinephrine 193-207 neuropeptide Y Homo sapiens 0-3 3209809-3 1988 Low concentrations of NPY (10(-8)-3 X 10(-7) mol.l-1) were more potent than equimolar concentrations of noradrenaline (NA). Norepinephrine 104-117 pro-neuropeptide Y Cavia porcellus 22-25 2978748-2 1988 The influence of intra-arterial infusion of rat atrial natriuretic factor (ANF 8-33) and/or ouabain on the vascular responses to noradrenaline was investigated in the denervated and flow-controlled hindlimb preparations in pentobarbital anaesthetized dogs. Norepinephrine 129-142 natriuretic peptide A Rattus norvegicus 48-73 2842284-5 1988 Synthesis of mucin, and its secretion in response to norepinephrine or cAMP, dropped precipitously to very low levels after 2 d. However, synthesis of DNA, general proteins, and glycoproteins dropped only transiently after 2 d, rising to levels approaching those of freshly dissociated complexes by 22 d. These data indicate that a shift occurred from the synthesis of large quantities of secretory proteins and glycoproteins, especially mucins, during the first 2 d in culture, to other materials thereafter. Norepinephrine 53-67 solute carrier family 13 member 2 Rattus norvegicus 13-18 3289995-3 1988 In response to the elevated insulin level (263 +/- 39 microU/ml), plasma glucose level fell (41 +/- 3 mg/dl), and levels of the counterregulatory hormones glucagon, epinephrine, norepinephrine, and cortisol increased (91 +/- 29 to 271 +/- 55 pg/ml, 83 +/- 26 to 2356 +/- 632 pg/ml, 128 +/- 31 to 596 +/- 81 pg/ml, and 1.5 +/- 0.4 to 11.1 +/- 1.0 micrograms/dl, respectively; for all, P less than .05). Norepinephrine 178-192 insulin Canis lupus familiaris 28-35 9608581-5 1998 NPY has been shown to inhibit locus coeruleus neuronal firing, decrease norepinephrine release, and increase postsynaptic noradrenergic signal transduction. Norepinephrine 72-86 neuropeptide Y Homo sapiens 0-3 9669490-2 1998 One such mediator is neuropeptide Y (NPY), which is co-localized with noradrenaline in sympathetic perivascular nerves. Norepinephrine 70-83 neuropeptide Y Homo sapiens 21-35 9669490-2 1998 One such mediator is neuropeptide Y (NPY), which is co-localized with noradrenaline in sympathetic perivascular nerves. Norepinephrine 70-83 neuropeptide Y Homo sapiens 37-40 9630349-2 1998 We investigated the potentiating effect of low concentrations of neuropeptide Y (NPY) on the vasoconstriction induced by transmural nerve stimulation (TNS) and noradrenaline (NA) in human saphenous veins. Norepinephrine 160-173 neuropeptide Y Homo sapiens 65-79 3133810-7 1988 The norepinephrine levels paralleled the t-PA activity. Norepinephrine 4-18 chromosome 20 open reading frame 181 Homo sapiens 41-45 3133810-11 1988 We conclude that desmopressin increases plasma norepinephrine in addition to t-PA and that the parallel time course of change suggests a possible role for norepinephrine in mediating endothelial cell t-PA release. Norepinephrine 155-169 chromosome 20 open reading frame 181 Homo sapiens 200-204 9630349-2 1998 We investigated the potentiating effect of low concentrations of neuropeptide Y (NPY) on the vasoconstriction induced by transmural nerve stimulation (TNS) and noradrenaline (NA) in human saphenous veins. Norepinephrine 160-173 neuropeptide Y Homo sapiens 81-84 9575810-0 1998 Norepinephrine stimulates arachidonic acid release from vascular smooth muscle via activation of cPLA2. Norepinephrine 0-14 phospholipase A2 group IVA Rattus norvegicus 97-102 9554647-15 1998 Significant differences between the two groups were found in the norepinephrine dosages at maximum values of S-TnT. Norepinephrine 65-79 troponin T1, slow skeletal type Homo sapiens 109-114 9489742-0 1998 Glucocorticoids provoke a shift from alpha2- to alpha1-adrenoreceptor activities in cultured hypothalamic slices leading to opposite noradrenaline effect on corticotropin-releasing hormone release. Norepinephrine 133-146 corticotropin releasing hormone Homo sapiens 157-188 9489742-1 1998 We have shown previously that noradrenaline (NA) stimulated or inhibited the release of corticotropin-releasing hormone (CRH) according to the availability of adrenal steroids. Norepinephrine 30-43 corticotropin releasing hormone Homo sapiens 88-119 9489742-1 1998 We have shown previously that noradrenaline (NA) stimulated or inhibited the release of corticotropin-releasing hormone (CRH) according to the availability of adrenal steroids. Norepinephrine 30-43 corticotropin releasing hormone Homo sapiens 121-124 9435281-5 1998 In particular, we show that, in the absence of MASH1, these neurons fail to initiate expression of the noradrenaline biosynthetic enzyme dopamine beta-hydroxylase. Norepinephrine 103-116 dopamine beta-hydroxylase Homo sapiens 137-162 3227888-2 1988 The effects of noradrenaline (NA)-induced vasoconstriction on the transcapillary passage of albumin was evaluated by an external detection technique, allowing repetitive measurements of albumin clearance (Cl) during various conditions (in the same animal). Norepinephrine 15-28 albumin Rattus norvegicus 92-99 3227888-2 1988 The effects of noradrenaline (NA)-induced vasoconstriction on the transcapillary passage of albumin was evaluated by an external detection technique, allowing repetitive measurements of albumin clearance (Cl) during various conditions (in the same animal). Norepinephrine 15-28 albumin Rattus norvegicus 186-193 3382942-1 1988 The apparently non-specific accumulation of c-fos proto-oncogene mRNA was found in rat hippocampus as a result of injection of either glutamate, noradrenaline, or physiological saline. Norepinephrine 145-158 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 44-49 3260379-3 1988 MPTP produced dose-dependent marked reductions in the concentrations of dopamine and noradrenaline in mouse brain 2 hours as well as 7 days after the administration. Norepinephrine 85-98 calbindin 1 Mus musculus 108-115 9535054-11 1998 Our data suggest the presence of several distinct types of catecholamine receptors in the rat intermediate lobe, and the dominant involvement of D-2 and beta-adrenergic receptors in the noradrenaline-induced regulation of melanotropes. Norepinephrine 186-199 solute carrier family 3 member 1 Rattus norvegicus 145-148 9539874-0 1998 Effects of norepinephrine on expression of IGF-1/IGF-1R and SERCA2 in rat heart. Norepinephrine 11-25 insulin-like growth factor 1 Rattus norvegicus 43-48 9366411-2 1997 In the present study, we proposed that the level of beta 2AR expression on anti-CD3 mAb-activated CD4+ effector Th cells may differ from the level on resting cells, and that a change in receptor expression may alter the functional responsiveness of these cells to either the beta 2AR-selective ligand terbutaline or the sympathetic neurotransmitter norepinephrine. Norepinephrine 349-363 adrenergic receptor, beta 2 Mus musculus 52-60 3348422-0 1988 Adenosine deaminase attenuates norepinephrine-induced coronary functional hyperemia. Norepinephrine 31-45 adenosine deaminase Canis lupus familiaris 0-19 3371399-6 1988 NPY suppressed the contractile effect of noradrenaline (NA) on isolated cerebral arteries and pretreatment with NPY suppressed the effect of NA on VBF, indicating that NPY contributes to the inhibitory modulation of postsynaptic adrenergic mechanisms. Norepinephrine 41-54 neuropeptide Y Canis lupus familiaris 0-3 2906499-1 1988 We investigated the direct pancreatic effects of noradrenaline in vivo on the secretion of insulin, glucagon, and somatostatin from the in situ pancreas in halothane-anaesthetized dogs. Norepinephrine 49-62 insulin Canis lupus familiaris 91-98 2906499-4 1988 The acute insulin response (AIR) to an intravenous injection of arginine (2.5 g), which was 4293 +/- 1260 microM min-1 under control conditions, was reduced to 1054 +/- 396 microU min-1 by noradrenaline (P less than 0.01). Norepinephrine 189-202 insulin Canis lupus familiaris 10-17 3340619-1 1988 Carbon disulfide (CS2), tetraethyl lead (TEL), tetraethyl tin (TeET), dithiothreitol (DTT), and gossypol acetic acid (GAA) significantly decreased brain norepinephrine (NE) in rats. Norepinephrine 153-167 calsyntenin 2 Rattus norvegicus 18-21 3340619-1 1988 Carbon disulfide (CS2), tetraethyl lead (TEL), tetraethyl tin (TeET), dithiothreitol (DTT), and gossypol acetic acid (GAA) significantly decreased brain norepinephrine (NE) in rats. Norepinephrine 153-167 alpha glucosidase Rattus norvegicus 118-121 2979688-3 1987 Noradrenaline and adrenaline relaxed gallbladder strips, probably via beta 2-adrenoceptor stimulation. Norepinephrine 0-13 adrenoceptor beta 2 Homo sapiens 70-89 3427094-6 1987 The inhibition by thyroid hormones may have implications for regulation of ADH catalysis of ethanol and alcohols in the intermediary metabolism of dopamine, norepinephrine, and serotonin and in steroid metabolism. Norepinephrine 157-171 aldo-keto reductase family 1 member A1 Homo sapiens 75-78 3138899-1 1987 Rat growth hormone-releasing factor (rGRF) and norepinephrine (NE) stimulate secretion of calcitonin (CT) and neurotensin (NT) from cultured C-cells. Norepinephrine 47-61 neurotensin Rattus norvegicus 110-121 9366411-9 1997 Additionally, norepinephrine down-modulates IL-2, but not IFN-gamma, production by binding specifically to the beta-adrenergic receptor. Norepinephrine 14-28 interleukin 2 Mus musculus 44-48 2890581-1 1987 Natriuretic substances were purified from rat atrium (atrial natriuretic factor, ANF) and were shown to be identical with the inhibitor of norepinephrine-induced contraction of smooth muscle. Norepinephrine 139-153 natriuretic peptide A Rattus norvegicus 54-79 2890581-1 1987 Natriuretic substances were purified from rat atrium (atrial natriuretic factor, ANF) and were shown to be identical with the inhibitor of norepinephrine-induced contraction of smooth muscle. Norepinephrine 139-153 natriuretic peptide A Rattus norvegicus 81-84 9329158-5 1997 Coronal sections of rat brain were processed to visualize immunoreactivity for the norepinephrine synthetic enzyme dopamine beta-hydroxylase (DBH), a specific marker for noradrenergic processes. Norepinephrine 83-97 dopamine beta-hydroxylase Rattus norvegicus 115-140 3040721-6 1987 The adrenergic agonists isoproterenol and norepinephrine blocked the elevation of cellular c-sis mRNA accompanying exposure to either thrombin or TGF-beta. Norepinephrine 42-56 platelet derived growth factor subunit B Homo sapiens 91-96 9329158-5 1997 Coronal sections of rat brain were processed to visualize immunoreactivity for the norepinephrine synthetic enzyme dopamine beta-hydroxylase (DBH), a specific marker for noradrenergic processes. Norepinephrine 83-97 dopamine beta-hydroxylase Rattus norvegicus 142-145 9421826-0 1997 Alprazolam, diazepam, yohimbine, clonidine: in vivo CA1 hippocampal norepinephrine and serotonin release profiles under chloral hydrate anesthesia. Norepinephrine 68-82 carbonic anhydrase 1 Rattus norvegicus 52-55 9334997-0 1997 Angiotensin converting enzyme inhibition improves baroreflex-induced noradrenaline spillover responses in rabbits with heart failure. Norepinephrine 69-82 angiotensin-converting enzyme Oryctolagus cuniculus 0-29 9389931-3 1997 Dexamethasone and noradrenaline suppressed secretion of IL-2, IFN alpha, IFN gamma, TNF alpha, IL-1 alpha and IL-1 beta. Norepinephrine 18-31 interleukin 1 alpha Homo sapiens 95-105 9299378-14 1997 In contrast, inhibition of cytosolic phospholipase A2 activity by the specific inhibitor AACOCF3 (1 micromol/l) prevented bradykinin-induced increase in noradrenaline release (S2/S1: 1.09+/-0.15; P<0.01). Norepinephrine 153-166 phospholipase A2 group IVA Rattus norvegicus 27-53 9299378-16 1997 Intraneuronal coupling of B2-receptors to phospholipase A2 appears to mediate the facilitatory effect of bradykinin on noradrenaline release in rat heart. Norepinephrine 119-132 phospholipase A2 group IB Rattus norvegicus 42-58 9353800-4 1997 Neurochemicals commonly reported in the vLGN and IGL are neuropeptide Y, GABA, enkephalin, and nitric oxide synthase (localized in cells) and serotonin, acetylcholine, histamine, dopamine and noradrenalin (localized in fibers). Norepinephrine 192-204 immunoglobulin lambda locus Homo sapiens 49-52 3683595-0 1987 Inhibition of noradrenaline release via presynaptic 5-HT1B receptors of the rat vena cava. Norepinephrine 14-27 5-hydroxytryptamine receptor 1B Rattus norvegicus 52-58 2441031-0 1987 The role of NADPH- and reduced glutathione-dependent enzymes in the norepinephrine modulation of the ATP-dependent, hepatic microsomal calcium pump: a new pathway for the noradrenergic regulation of cytosolic calcium in the hepatocyte. Norepinephrine 68-82 2,4-dienoyl-CoA reductase 1 Homo sapiens 12-17 2441031-6 1987 At 10(-7) to 10(-6) M norepinephrine, with either NADP+ or NADPH, the uptake was significantly lower than at other norepinephrine concentrations. Norepinephrine 22-36 2,4-dienoyl-CoA reductase 1 Homo sapiens 59-64 2441031-6 1987 At 10(-7) to 10(-6) M norepinephrine, with either NADP+ or NADPH, the uptake was significantly lower than at other norepinephrine concentrations. Norepinephrine 115-129 2,4-dienoyl-CoA reductase 1 Homo sapiens 59-64 3032791-4 1987 The sensitivity of norepinephrine-precontracted aorta to ANP was significantly reduced in DOCA-salt hypertensive rats (p less than 0.001). Norepinephrine 19-33 natriuretic peptide A Rattus norvegicus 57-60 2884590-0 1987 Behavioural and biochemical evidence for the release of noradrenaline in mouse brain by TRH and some of its biologically stable analogues. Norepinephrine 56-69 thyrotropin releasing hormone Mus musculus 88-91 2884590-14 1987 Viewed overall, the data showed that TRH and its analogues induced the release of noradrenaline in the brain. Norepinephrine 82-95 thyrotropin releasing hormone Mus musculus 37-40 3031661-5 1987 Additional studies with muscle slices incubated with [3H]norepinephrine or [3H]choline showed that neuropeptide Y stimulated norepinephrine release from sympathetic nerves, which, in turn, inhibited the release of acetylcholine via alpha 2 receptors located on postganglionic nerves. Norepinephrine 57-71 pro-neuropeptide Y Cavia porcellus 99-113 3030118-3 1987 Epinephrine (E), isoproterenol (I), and dopamine (D) were compared with norepinephrine (N) for production of microthrombi during thrombin-induced disseminated intravascular coagulation (DIC) in rabbits. Norepinephrine 72-86 prothrombin Oryctolagus cuniculus 129-137 9288221-1 1997 Neuropeptide Y (NPY) is co-localized with noradrenaline (NA) in perivascular sympathetic nerve and is a vasoconstrictor. Norepinephrine 42-55 neuropeptide Y Homo sapiens 0-14 3575912-1 1987 Neuropeptide-Y (NPY) is a peptide co-localised with noradrenaline in many sympathetic nerves. Norepinephrine 52-65 neuropeptide Y Felis catus 0-14 3575912-1 1987 Neuropeptide-Y (NPY) is a peptide co-localised with noradrenaline in many sympathetic nerves. Norepinephrine 52-65 neuropeptide Y Felis catus 16-19 9288221-1 1997 Neuropeptide Y (NPY) is co-localized with noradrenaline (NA) in perivascular sympathetic nerve and is a vasoconstrictor. Norepinephrine 42-55 neuropeptide Y Homo sapiens 16-19 9533823-2 1997 The present study was carried out with the aim of elucidating the mechanism of PAF action on vasoconstrictive response to noradrenaline (NA-R) in the presence of autologous platelets. Norepinephrine 122-135 PCNA clamp associated factor Homo sapiens 79-82 9533823-2 1997 The present study was carried out with the aim of elucidating the mechanism of PAF action on vasoconstrictive response to noradrenaline (NA-R) in the presence of autologous platelets. Norepinephrine 137-141 PCNA clamp associated factor Homo sapiens 79-82 9533823-4 1997 PAF action through stimulation of platelets by noradrenaline (NA) was explored during infusion of platelet rich plasma (PRP) with PAF into the perfusion circuit. Norepinephrine 47-60 PCNA clamp associated factor Homo sapiens 0-3 9533823-8 1997 Thus, it is concluded that PAF action on NA-R through platelets may be related partly to neurotransmitters originating from perivascular autonomic depressant nerves stimulated by some neuroeffector agents. Norepinephrine 41-45 PCNA clamp associated factor Homo sapiens 27-30 9112832-3 1997 Superimposition of norepinephrine and gauche forms of serotonin and mociobemide suggest that the phenyl ring, electronegative group attached to the aromatic ring and the amine terminal group may serve as the recognition elements for binding to monoamine oxidase-A (MAO-A). Norepinephrine 19-33 monoamine oxidase A Homo sapiens 244-263 9112832-3 1997 Superimposition of norepinephrine and gauche forms of serotonin and mociobemide suggest that the phenyl ring, electronegative group attached to the aromatic ring and the amine terminal group may serve as the recognition elements for binding to monoamine oxidase-A (MAO-A). Norepinephrine 19-33 monoamine oxidase A Homo sapiens 265-270 9122267-10 1997 Oxytocin appeared to act to stimulate norepinephrine terminals in the medial basal hypothalamus, which activated NOS by alpha1-adrenergic receptors, because prazocine, an alpha1 receptor blocker, inhibited the LHRH-releasing action of oxytocin. Norepinephrine 38-52 gonadotropin releasing hormone 1 Rattus norvegicus 210-214 9054387-4 1997 The increase in AA-NAT mRNA is generated by norepinephrine acting through a cAMP mechanism. Norepinephrine 44-58 aralkylamine N-acetyltransferase Rattus norvegicus 16-22 9091308-5 1997 After pre-incubation with PDGF-AB or TGF-beta 1 in the presence of CRH or ACTH, norepinephrine and epinephrine release falls. Norepinephrine 80-94 corticotropin releasing hormone Homo sapiens 67-70 9074703-8 1997 Plasma SSAO correlated with plasma atrial natriuretic peptide (r = 0.42; P < 0.0001), with plasma norepinephrine (r = 0.27; P < 0.0001) and with left ventricular ejection fraction (r = -0.13; P = 0.0162). Norepinephrine 101-115 amine oxidase copper containing 2 Homo sapiens 7-11 3544861-0 1987 Neurotensin releases norepinephrine differentially from perfused hypothalamus of sated and fasted rat. Norepinephrine 21-35 neurotensin Rattus norvegicus 0-11 3442342-5 1987 In addition, the pulmonary arterial blood temperature and the noradrenaline plasma concentrations (double isotope enzymatic assay) increased significantly during period 2. Norepinephrine 62-75 period circadian regulator 2 Homo sapiens 162-170 3452452-1 1987 Topical application of a standard dose of noradrenaline (NA) to the anesthetized rat mesentery evoked a vasoconstrictor response the latency of which was increased in a dose-dependent way by previous addition of PAF-acether or histamine but not by Lyso-PAF. Norepinephrine 42-55 PCNA clamp associated factor Rattus norvegicus 212-215 3452452-1 1987 Topical application of a standard dose of noradrenaline (NA) to the anesthetized rat mesentery evoked a vasoconstrictor response the latency of which was increased in a dose-dependent way by previous addition of PAF-acether or histamine but not by Lyso-PAF. Norepinephrine 42-55 PCNA clamp associated factor Rattus norvegicus 253-256 3480939-2 1987 However, availability of other selective MAO-B inhibitors have clearly shown that this is not the case, since the "cheese effect" is associated with the selective inhibition of MAO-A, the enzyme responsible for intraneuronal oxidation of noradrenaline. Norepinephrine 238-251 monoamine oxidase B Homo sapiens 41-46 3466164-0 1986 Human class II (pi) alcohol dehydrogenase has a redox-specific function in norepinephrine metabolism. Norepinephrine 75-89 aldo-keto reductase family 1 member A1 Homo sapiens 20-41 2945673-7 1986 There was an excellent correlation between plasma norepinephrine and renin activity before the animals were killed in both the VP1 and VP2 groups (r = .88, p less than .001). Norepinephrine 50-64 renin Canis lupus familiaris 69-74 2434752-6 1986 In addition, on atria and on ventricles, adenylate cyclase was activated by norepinephrine (presumably by beta 1- and beta 2-adrenoceptor stimulation) and by procaterol (by beta 2-adrenoceptor stimulation). Norepinephrine 76-90 adrenoceptor beta 2 Homo sapiens 118-137 9023284-3 1997 By studying influence of appropriate adrenoceptor blockers, qualitative characteristics of the inotropic response and sensitivity of the inotropic response to cholinergic stimulation, it was revealed that norepinephrine evoked both alpha-1 and beta adrenoceptor-mediated inotropic effects in failing human ventricle myocardium. Norepinephrine 205-219 adrenoceptor alpha 1D Homo sapiens 232-248 9023284-5 1997 Concomitant stimulation of alpha-1 and beta adrenoceptors by norepinephrine alone revealed a contribution of an alpha-1 adrenoceptor-mediated component to the final and unopposed inotropic response. Norepinephrine 61-75 adrenoceptor alpha 1D Homo sapiens 27-43 9241547-0 1997 Effect of the alpha-1 adrenoceptor blocker on tissue norepinephrine contents in human benign prostatic hyperplasia. Norepinephrine 53-67 adrenoceptor alpha 1D Homo sapiens 14-21 8922421-3 1996 It has been shown previously that Phox2 is such a homeodomain protein, expressed exclusively in differentiated groups of neurons or their precursors, and that its expression correlated with that of the noradrenaline synthesis enzyme dopamine-beta-hydroxylase. Norepinephrine 202-215 dopamine beta-hydroxylase Homo sapiens 233-258 3800944-0 1986 Effect of adenosine deaminase, N6-phenylisopropyladenosine and hypothyroidism on the responsiveness of rat brown adipocytes to noradrenaline. Norepinephrine 127-140 adenosine deaminase Rattus norvegicus 10-29 3800944-1 1986 Adenosine deaminase (1 unit/ml) potentiated the lipolytic action of noradrenaline in adipocytes isolated from brown adipose tissue of 1- and 6-week-old rats by decreasing the EC50 (concn. Norepinephrine 68-81 adenosine deaminase Rattus norvegicus 0-19 3800944-3 1986 With cells from neonatal rabbit tissue, adenosine deaminase only had a small, non-significant, effect on the EC50 for noradrenaline. Norepinephrine 118-131 adenosine deaminase Oryctolagus cuniculus 40-59 3800944-8 1986 Responsiveness of lipolysis to noradrenaline was particularly decreased in hypothyroidism and was partially restored by addition of adenosine deaminase. Norepinephrine 31-44 adenosine deaminase Rattus norvegicus 132-151 2875175-2 1986 Maximum contraction with thrombin represented between 50 and 66% of the maximum arterial response to norepinephrine (NE). Norepinephrine 101-115 prothrombin Oryctolagus cuniculus 25-33 3762738-1 1986 Utilizing a specific "low substrate concentration technique", intrasynaptosomal MAO-A and MAO-B activities within the rat brain noradrenaline system were studied. Norepinephrine 128-141 monoamine oxidase B Rattus norvegicus 90-95 3717362-6 1986 ADA completely blocked the norepinephrine-induced vasodilation (n = 6). Norepinephrine 27-41 adenosine deaminase Canis lupus familiaris 0-3 3700383-3 1986 Treatment of the cells with either norepinephrine or epinephrine in the range of 0.05-0.2 mM for 24 h resulted in a 3-20-fold increase in NGF content in the medium of the L-M cells. Norepinephrine 35-49 nerve growth factor Mus musculus 138-141 3700383-7 1986 These results suggested that norepinephrine and epinephrine stimulated the de novo synthesis and secretion of NGF protein. Norepinephrine 29-43 nerve growth factor Mus musculus 110-113 3005093-1 1986 The response to insulin-induced hypoglycemia includes increased plasma levels of glucagon, epinephrine, norepinephrine, cortisol, and growth hormone. Norepinephrine 104-118 insulin Canis lupus familiaris 16-23 8944402-3 1996 In comparison with lorazepam (2 mg), alprazolam (1 mg) showed reduced MBP levels during supine rest, whereas lorazepam showed a higher heart rate level during supine rest, a reduced plasma noradrenaline response to the OCT and a performance deterioration to the CWT. Norepinephrine 189-202 plexin A2 Homo sapiens 219-222 8878434-7 1996 Preincubation of cells with insulin or IGF-I enhanced subsequent norepinephrine stimulation of mitogen activated kinase activity. Norepinephrine 65-79 insulin-like growth factor 1 Rattus norvegicus 39-44 8938587-14 1996 Levels of mRNA encoding the glucocorticoid-dependent enzyme phenylethanolamine N-methyltransferase which catalyses the conversion of noradrenaline to adrenaline, were also significantly reduced in those rats given glycyrrhizic acid (1.12 +/- 0.04 vs 0.78 +/- 0.04), while those for the glucocorticoid-independent enzyme tyrosine hydroxylase (1.9 kb), which catalyses the conversion of tyrosine to DOPA, were unchanged (0.64 +/- 0.04 vs 0.61 +/- 0.04). Norepinephrine 133-146 phenylethanolamine-N-methyltransferase Rattus norvegicus 60-98 3028057-3 1986 The purpose of the present study was to investigate the effects of norepinephrine, isoproterenol, methacholine, and cholecystokinin on the simultaneous release of kallikrein and tonin from the rat submandibular gland. Norepinephrine 67-81 kallikrein 1-related peptidase C2 Rattus norvegicus 178-183 3028057-7 1986 Similarly, norepinephrine at 10(-5) M enhanced the release of tonin from a basal rate of 4.4 +/- 0.6 to 57 +/- 14.4 ng/min/mg tissue (p less than .05), and at 10(-4) M the rate increased to 91.3 +/- 20.0 ng/min/mg tissue (p less than .01). Norepinephrine 11-25 kallikrein 1-related peptidase C2 Rattus norvegicus 62-67 2948068-0 1986 Human atrial natriuretic factor prevents against norepinephrine-induced acute renal failure in the rat. Norepinephrine 49-63 natriuretic peptide A Rattus norvegicus 6-31 2948068-1 1986 The aim of the present study was to investigate the potential protective effect of atrial natriuretic factor (ANF) on the norepinephrine (NE)-induced acute renal failure (ARF). Norepinephrine 122-136 natriuretic peptide A Rattus norvegicus 83-108 2948068-1 1986 The aim of the present study was to investigate the potential protective effect of atrial natriuretic factor (ANF) on the norepinephrine (NE)-induced acute renal failure (ARF). Norepinephrine 122-136 natriuretic peptide A Rattus norvegicus 110-113 2948068-5 1986 ANF pretreatment prevented the norepinephrine-induced ARF. Norepinephrine 31-45 natriuretic peptide A Rattus norvegicus 0-3 20493043-2 1986 Noradrenaline synthesis is depressed by adenosine deaminase and the adenosine antagonist, 8-phenyltheophylline and stimulated by the adenosine agonist, 2-chloroadenosine. Norepinephrine 0-13 adenosine deaminase Rattus norvegicus 40-59 8897640-3 1996 The aim of the present work was to investigate BNP and CNP effects on the uptake and release of norepinephrine (NE) in rat hypothalamic slices incubated in vitro. Norepinephrine 96-110 2',3'-cyclic nucleotide 3' phosphodiesterase Rattus norvegicus 55-58 8781343-3 1996 Kupffer cells have been implicated as the source of prostanoids in the anaphylatoxin-dependent signalling chain and Ito cells in the nerve stimulation-dependent signalling chain, because anaphylatoxins and noradrenaline increased prostanoid synthesis in isolated Kupffer and Ito cells, respectively. Norepinephrine 206-219 complement C5 Rattus norvegicus 71-84 8828539-2 1996 Neuropeptide Y (NPY) is co-localized with norepinephrine in sympathetic perivascular nerves. Norepinephrine 42-56 neuropeptide Y Homo sapiens 0-14 8828539-2 1996 Neuropeptide Y (NPY) is co-localized with norepinephrine in sympathetic perivascular nerves. Norepinephrine 42-56 neuropeptide Y Homo sapiens 16-19 8828539-3 1996 NPY is released with norepinephrine on sympathetic nerve stimulation and produces long-lasting vasoconstriction of the nasal vascular bed. Norepinephrine 21-35 neuropeptide Y Homo sapiens 0-3 8898322-4 1996 Decreased availability of estrogen may also increase the levels of neuropeptide Y, leading to decreased release of noradrenaline from the ventromedial hypothalamus. Norepinephrine 115-128 neuropeptide Y Homo sapiens 67-81 8898322-5 1996 The increased noradrenaline content may increase the concentration of galanin, which will decrease the circulating levels of insulin and increase the pace of transcription of the neuropeptide Y gene. Norepinephrine 14-27 neuropeptide Y Homo sapiens 179-193 8759029-5 1996 The marked susceptibility to down-regulation displayed by PKC-alpha and -delta was accompanied by an enhanced secretory response to norepinephrine as compared with control cells. Norepinephrine 132-146 protein kinase C, alpha Rattus norvegicus 58-78 2935879-2 1986 We have now found that this natriuretic effect of ANF is associated with a suppression of the initially elevated urinary excretion of norepinephrine and epinephrine and increase of the excretion of the main dopamine metabolite-dihydroxyphenylacetic acid as well as of the urinary dopamine to norepinephrine ratio. Norepinephrine 134-148 natriuretic peptide A Rattus norvegicus 50-53 2935879-2 1986 We have now found that this natriuretic effect of ANF is associated with a suppression of the initially elevated urinary excretion of norepinephrine and epinephrine and increase of the excretion of the main dopamine metabolite-dihydroxyphenylacetic acid as well as of the urinary dopamine to norepinephrine ratio. Norepinephrine 292-306 natriuretic peptide A Rattus norvegicus 50-53 2999616-13 1985 As expected from beta 1-adrenoceptors, the high-sensitivity component of the curve for (-)-noradrenaline was selectively antagonized by (-)-bisoprolol; as expected from beta 2-adrenoceptors, the low-sensitivity component was selectively antagonized by ICI 118,551. Norepinephrine 87-104 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 17-23 3903555-3 1985 Strongly GR immunoreactive nerve cells were mainly found in the area of the noradrenaline, adrenaline and 5-hydroxytryptamine (5-HT) cell groups of the lower brain stem, and of the substantia gelatinosa of the nuc. Norepinephrine 76-89 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 9-11 3161659-0 1985 Atrial natriuretic factor inhibits the hypertension induced by chronic infusion of norepinephrine in conscious rats. Norepinephrine 83-97 natriuretic peptide A Rattus norvegicus 0-25 3161659-3 1985 When the same dose of atrial natriuretic factor was administered simultaneously with 1.8 mg/kg per day of norepinephrine infused intraperitoneally by osmotic minipumps, the systolic blood pressure of conscious rats rose on day 1 to only 127.3 +/- 6.3 mm Hg compared with the rise to 146.3 +/- 1.6 mm Hg when norepinephrine alone was infused (P less than 0.05). Norepinephrine 308-322 natriuretic peptide A Rattus norvegicus 22-47 3161659-4 1985 The antihypertensive effect of atrial natriuretic factor was sustained for 3 days in rats infused with norepinephrine. Norepinephrine 103-117 natriuretic peptide A Rattus norvegicus 31-56 3161659-5 1985 The administration of atrial natriuretic factor to rats made hypertensive by 3 days of infusion with norepinephrine alone returned the blood pressure to control levels, and the antihypertensive effect was sustained throughout the experimental period lasting for 3 days. Norepinephrine 101-115 natriuretic peptide A Rattus norvegicus 22-47 2992694-2 1985 In caudal regions, GAD-stained cells were adjacent to the "precerebellar" lateral reticular nucleus and partially overlapped the A1 area of norepinephrine synthesizing neurons. Norepinephrine 140-154 glutamate decarboxylase 1 Homo sapiens 19-22 3930975-2 1985 Isoprenaline, adrenaline and noradrenaline stimulated pepsinogen release in a dose-dependent manner with similar maximal effects, but isoprenaline was significantly more potent than the other two agonists. Norepinephrine 29-42 pepsin II-2/3 Oryctolagus cuniculus 54-64 4069759-2 1985 The mechanism whereby norepinephrine elicits thrombosis during intravascular coagulation was investigated further in rabbits given a 4 h infusion of thrombin (1 NIH unit/kg/min). Norepinephrine 22-36 prothrombin Oryctolagus cuniculus 149-157 4069759-6 1985 Study of the glomerular circulation with colloidal carbon showed that norepinephrine elicits severe glomerular capillary stasis in thrombin treated rabbits; the vasomotor reaction precedes increased fibrinogen consumption and focal deposition of fibrin in the glomeruli. Norepinephrine 70-84 prothrombin Oryctolagus cuniculus 131-139 3997236-6 1985 Both plasma norepinephrine levels and the fall in mean arterial pressure after ganglionic blockade decreased during intrarenal adenosine deaminase infusion in one-kidney, one-clip animals. Norepinephrine 12-26 adenosine deaminase Rattus norvegicus 127-146 3997236-7 1985 Renal denervation in one-kidney, one-clip animals prevented the changes in mean arterial pressure and plasma norepinephrine levels during intrarenal adenosine deaminase infusion. Norepinephrine 109-123 adenosine deaminase Rattus norvegicus 149-168 3921855-7 1985 Even in intact tissues MAO B may play a role in the metabolism (but not in the inactivation) of noradrenaline by deaminating the NMN formed from noradrenaline and giving preferentially origin to MOPEG. Norepinephrine 96-109 monoamine oxidase B Canis lupus familiaris 23-28 3921855-7 1985 Even in intact tissues MAO B may play a role in the metabolism (but not in the inactivation) of noradrenaline by deaminating the NMN formed from noradrenaline and giving preferentially origin to MOPEG. Norepinephrine 145-158 monoamine oxidase B Canis lupus familiaris 23-28 3921856-0 1985 Influence of MAO A and MAO B on the inactivation of noradrenaline in the saphenous vein of the dog. Norepinephrine 52-65 monoamine oxidase B Canis lupus familiaris 23-28 2579383-1 1985 Noradrenaline, apparently working through activation of beta-adrenergic receptors, alters the state of phosphorylation of a substantial proportion of synapsin I in rat frontal cortex. Norepinephrine 0-13 synapsin I Rattus norvegicus 150-160 2579383-2 1985 Since synapsin I is enriched in virtually all axon terminals in this brain region, the results indicate that noradrenaline, a sparsely distributed neurotransmitter, affects a large number of axon terminals in this region. Norepinephrine 109-122 synapsin I Rattus norvegicus 6-16 20487821-2 1981 Cholecystokinin octapeptide sulphate ester and the tyrosine-sulphate-methionine and tyrosine-sulphate-methionine-glycine fragments increased the dopamine and norepinephrine contents of the hypothalamus and mesencephalon. Norepinephrine 158-172 cholecystokinin Rattus norvegicus 0-15 7255763-8 1980 The potent inhibitory effects of locally applied NT appear to result from release of the inhibitory transmitter, norepinephrine from locus coeruleus-derived afferents. Norepinephrine 113-127 neurotensin Rattus norvegicus 49-51 7255763-9 1980 We postulate that the excitations, which appear when postsynaptic effects of norepinephrine are antagonized or release is reduced, may be the direct result of NT action at the postsynaptic P neuron membrane. Norepinephrine 77-91 neurotensin Rattus norvegicus 159-161 7463880-3 1980 However, since a tendency to increase in norepinephrine turnover rate after CCK injection was noticed, the possibility that brain monoamines are involved in the central action of CCK could not be excluded. Norepinephrine 41-55 cholecystokinin Rattus norvegicus 76-79 222624-4 1979 beta-Endorphin, VIP, secretin, and glucagon all produce discrete changes in norepinephrine turnover in various hypothalamic nuclei. Norepinephrine 76-90 secretin Rattus norvegicus 21-29 378326-6 1979 Interactions of neurotensin with other neurotransmitter candidates are also suggested by its presence in areas enriched in norepinephrine, dopamine, serotonin, and substance P. Certain neurotensin localizations suggest an association of the peptide with functional brain systems preferentially involving these regions. Norepinephrine 123-137 neurotensin Rattus norvegicus 16-27 287079-4 1979 In brown adipocytes, the Ca2+ ionophore A23187 and the Na+ ionophore monensin increase respiration if substrate is added, and incubation in a low-Na+ buffer decreases norepinephrine-induced respiration. Norepinephrine 167-181 carbonic anhydrase 2 Homo sapiens 25-28 713169-0 1978 [Studies on hypertension: I) The effects of angiotensin II and norepinephrine infusion on renal hemodynamics and renin angiotensin system in anesthetized dogs. Norepinephrine 63-77 renin Canis lupus familiaris 113-118 212018-8 1978 Adenosine deaminase corrected the differences in response to noradrenaline and glucagon resulting from adrenalectomy. Norepinephrine 61-74 adenosine deaminase Rattus norvegicus 0-19 212018-10 1978 In the presence of adenosine deaminase rates of lipolysis, after stimulation by high concentrations of noradrenaline, glucagon, corticotropin or theophylline, were the same in cells from adrenalectomized or sham-operated rats. Norepinephrine 103-116 adenosine deaminase Rattus norvegicus 19-38 672009-1 1978 The effect of a single insulin injection on the reaction of the coronary vessels to adrenaline, noradrenaline, and acetylcholine was studied in experiments on dogs. Norepinephrine 96-109 insulin Canis lupus familiaris 23-30 672009-2 1978 Insulin induces a decrease of arterial pressure and of the resistance of the coronary and peripheral vessels reduces the reflex cholinergic and beta-adrenergic reactions of dilatation of the coronary vessels, and promotes alpha-adrenergic reactions in intracoronary administration of adrenaline and noradrenaline. Norepinephrine 299-312 insulin Canis lupus familiaris 0-7 674813-0 1978 Rat hippocampal norepinephrine response to cholinesterase inhibition. Norepinephrine 16-30 butyrylcholinesterase Rattus norvegicus 43-57 674813-2 1978 Results indicate that this cholinesterase inhibiting compound caused a significant decrease (congruent to 14%) in hippocampal norepinephrine within 3 hours of exposure. Norepinephrine 126-140 butyrylcholinesterase Rattus norvegicus 27-41 674817-3 1978 Following acute myocardial infarction, significant correlations were found to exist between plasma norepinephrine and plasma renin activity and between the levels of these vasoactive substances and the measured indices of ischemic damage. Norepinephrine 99-113 renin Canis lupus familiaris 125-130 193126-0 1977 Action of tonin on the response of rat on mesenteric vessels to norepinephrine. Norepinephrine 64-78 kallikrein 1-related peptidase C2 Rattus norvegicus 10-15 861305-3 1977 It was found that human blood plasma after the contact with norepinephrine loses its ability to increase the BAEE-esterase activity, when tanic acid, which activates factor XII (Hageman factor), was added. Norepinephrine 60-74 coagulation factor XII Homo sapiens 178-192 192922-4 1977 Intrarenal arterial infusion of norepinephrine at a control pressure increased a renin secretion. Norepinephrine 32-46 renin Canis lupus familiaris 81-86 192922-5 1977 However, norepinephrine infusion at a reduced pressure suppressed the renin release with a recovery of the vascular resistance to the control level. Norepinephrine 9-23 renin Canis lupus familiaris 70-75 186790-2 1976 The concentrations by bioassay of nerve growth factor in both epinephrine- and norepinephrine-induced saliva (3400 and 900 mug/ml, respectively) are higher than reported in any other source. Norepinephrine 79-93 nerve growth factor Mus musculus 34-53 186790-4 1976 The specific activity of the salivary nerve growth factor was 41, 36, 2, and 0.6 mug/mg of protein in secretions elicited by epinephrine, norepinephrine, pilocarpine, and isoproterenol, respectively. Norepinephrine 138-152 nerve growth factor Mus musculus 38-57 1023189-3 1976 Noradrenaline (1--2 Mg/kg/min) produced the contrary changes in the renin secretion and diuresis, this being associated with a different activity of catecholamines in respect to tha alpha- and beta-adrenoreceptors. Norepinephrine 0-13 renin Canis lupus familiaris 68-73 966375-5 1976 Intrarenal arterial infusion of norepinephrine at a control pressure increased a renin release. Norepinephrine 32-46 renin Canis lupus familiaris 81-86 966375-6 1976 However, norepinephrine infusion at reduced pressure suppressed the renin release with recovery a vascular resistance to the control level. Norepinephrine 9-23 renin Canis lupus familiaris 68-73 1208233-0 1975 The activation of the renin--angiotensin system in the dog after injection of noradrenaline into the lateral brain ventricle. Norepinephrine 78-91 renin Canis lupus familiaris 22-27 1153091-0 1975 The effect of ketamine HC1 on the in vitro metabolism of norepinephrine in rat cerebral cortex tissue. Norepinephrine 57-71 Hypercalciuria QTL 1 Rattus norvegicus 23-26 1115240-7 1975 In additional experiments in which the plasma renin level was measured, the potentiation of responses to sympathetic stimulation and a high dose of norepinephrine (2 mug) occurred at the time that the renin level was increased by hemorrhage. Norepinephrine 148-162 renin Canis lupus familiaris 46-51 1115240-7 1975 In additional experiments in which the plasma renin level was measured, the potentiation of responses to sympathetic stimulation and a high dose of norepinephrine (2 mug) occurred at the time that the renin level was increased by hemorrhage. Norepinephrine 148-162 renin Canis lupus familiaris 201-206 4766218-4 1973 Elastin binds the (-)-isomer of adrenaline and noradrenaline to twice the extent of the (+)-isomer.3. Norepinephrine 47-60 elastin Rattus norvegicus 0-7 4766218-10 1973 The results of the study suggest that in tissues with a high content of collagen and elastin, binding to extracellular sites is the major mechanism for terminating the response to noradrenaline or to adrenergic nerve stimulation. Norepinephrine 180-193 elastin Rattus norvegicus 85-92 4403383-5 1972 Plasma cyclic GMP rose in response to infusions of alpha-adrenergic agents, viz., epinephrine or norepinephrine infused together with the beta-blocking agent, propranolol. Norepinephrine 97-111 5'-nucleotidase, cytosolic II Homo sapiens 14-17 5279472-0 1971 Changes in activity of choline acetylase in central nervous system of rat after intraventricular administration of noradrenaline. Norepinephrine 115-128 choline O-acetyltransferase Rattus norvegicus 23-40 13795313-1 1959 Pyrogallol inhibits the Omethylation of epinephrine and norepinephrine by catechol-O-methyl transferase in vitro as well as the metabolism of these catecholamines, and the formation of their O-methylated metabolites, in the intact mouse. Norepinephrine 56-70 catechol-O-methyltransferase Mus musculus 74-103 33751565-6 2021 In vitro, the treatments of MDSCs with epinephrine (EPI) and norepinephrine (NE) but not corticosterone (CORT) treated H22 conditioned medium obviously inhibited T cell proliferation, as well as enhanced CXCR2 expression and Erk phosphorylation. Norepinephrine 61-75 chemokine (C-X-C motif) receptor 2 Mus musculus 204-209 33988526-2 2021 While norepinephrine is usually delivered at a concentration of 16 to 32 mug/mL, out of concern for extravasation and interstitial necrosis, some patients receive more dilute norepinephrine solutions through peripheral intravenous catheters. Norepinephrine 6-20 thrombopoietin Mus musculus 77-79 33988526-3 2021 We describe a case of severe hyponatremia and seizure resulting from administration of norepinephrine concentrated at 4 mug/mL in dextrose 5% in water. Norepinephrine 87-101 thrombopoietin Mus musculus 124-126 33580322-2 2021 Hindbrain noradrenergic neurons innervate the VMN, where norepinephrine regulates nNOS and GAD expression. Norepinephrine 57-71 glutamate decarboxylase 1 Homo sapiens 91-94 33895869-5 2021 The exclusion of norepinephrine (NE) from synaptic vesicles leads to its oxidation into the toxic metabolite 3,4-dihydroxyphenyl glycolaldehyde (DOPEGAL), which subsequently activates cleavage of Tau at N368 by asparagine endopeptidase (AEP) and triggers LC neurodegeneration. Norepinephrine 17-31 legumain Homo sapiens 211-235 33895869-5 2021 The exclusion of norepinephrine (NE) from synaptic vesicles leads to its oxidation into the toxic metabolite 3,4-dihydroxyphenyl glycolaldehyde (DOPEGAL), which subsequently activates cleavage of Tau at N368 by asparagine endopeptidase (AEP) and triggers LC neurodegeneration. Norepinephrine 17-31 legumain Homo sapiens 237-240 8759029-6 1996 Further, the selective PKC inhibitors Ro 31-8220 and CGP 41,251 also produced a concentration-dependent enhancement of norepinephrine-induced amylase secretion. Norepinephrine 119-133 protein kinase C, alpha Rattus norvegicus 23-26 8864538-0 1996 Inhibition of exocytotic noradrenaline release by presynaptic cannabinoid CB1 receptors on peripheral sympathetic nerves. Norepinephrine 25-38 cannabinoid receptor 1 Rattus norvegicus 74-77 8897649-4 1996 Colocalization studies of tyrosine hydroxylase (TH) and Fos protein revealed that in the brainstem, 73 to 85% of noradrenaline-containing cells expressed Fos immunoreactivity. Norepinephrine 113-126 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 56-59 33515535-0 2021 Norepinephrine inhibits migration and invasion of human glioblastoma cell cultures possibly via MMP-11 inhibition. Norepinephrine 0-14 matrix metallopeptidase 11 Homo sapiens 96-102 33515535-9 2021 Human Tumor Metastasis RT2 Profiler PCR Array assay showed that matrix metallopeptidase-11 (MMP-11) was decreased following norepinephrine treatment. Norepinephrine 124-138 matrix metallopeptidase 11 Homo sapiens 64-90 33515535-9 2021 Human Tumor Metastasis RT2 Profiler PCR Array assay showed that matrix metallopeptidase-11 (MMP-11) was decreased following norepinephrine treatment. Norepinephrine 124-138 matrix metallopeptidase 11 Homo sapiens 92-98 33367607-5 2021 Repeated exposure to norepinephrine or salbutamol suppressed both the glucagon and epinephrine responses to hypoglycemia compared to controls. Norepinephrine 21-35 glucagon Rattus norvegicus 70-78 32956676-6 2021 The present studies focused on the initial characterization of a novel atypical DAT inhibitor, CT-005404, which binds to DAT with high selectivity relative to serotonin and norepinephrine transport, and produces long-term elevations of extracellular DA. Norepinephrine 173-187 solute carrier family 6 member 3 Homo sapiens 80-83 33483878-5 2022 Studies in different experimental animal species and in humans indicate that KOR agonists decrease antidiuretic hormone (ADH) secretion and release from the hypothalamus and posterior pituitary; decrease response to ADH in kidneys; increase renal sympathetic nerve activity; and increase adrenaline, noradrenaline, and dopamine release from the adrenal medulla. Norepinephrine 300-313 opioid receptor kappa 1 Homo sapiens 77-80 32662924-0 2021 Microglial CX3CR1 production increases in Alzheimer"s disease and is regulated by noradrenaline. Norepinephrine 82-95 C-X3-C motif chemokine receptor 1 Homo sapiens 11-17 32942081-1 2020 Monoamine oxidases (MAO-A and MAO-B) are mammalian flavoenzyme, which catalyze the oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine, serotonin, and some other amines. Norepinephrine 139-153 monoamine oxidase B Homo sapiens 30-35 33020652-4 2020 Intrathecal norepinephrine induced mechanical pain hypersensitivity via alpha1A-ARs in Hes5+ astrocytes, and chemogenetic stimulation of Hes5+ SDH astrocytes was sufficient to produce the hypersensitivity. Norepinephrine 12-26 hes family bHLH transcription factor 5 Homo sapiens 87-91 33020652-4 2020 Intrathecal norepinephrine induced mechanical pain hypersensitivity via alpha1A-ARs in Hes5+ astrocytes, and chemogenetic stimulation of Hes5+ SDH astrocytes was sufficient to produce the hypersensitivity. Norepinephrine 12-26 hes family bHLH transcription factor 5 Homo sapiens 137-141 32520577-5 2020 The relationship between the norepinephrine infusion rate and the use of beta-blockers and plasma cytokines was assessed in 195 patients with septic shock.Measurements and Main Results: Norepinephrine attenuated the production of proinflammatory mediators and reactive oxygen species and augmented antiinflammatory IL-10 production both in vitro and in LPS-challenged mice. Norepinephrine 186-200 interleukin 10 Homo sapiens 315-320 32811805-3 2020 We observed that beta-catenin co-expressed with SLUG and norepinephrine (NE) in tumor tissues obtained from nude mice. Norepinephrine 57-71 catenin (cadherin associated protein), beta 1 Mus musculus 17-29 32623336-4 2020 We demonstrated that YAP1 was dephosphorylated and translocated from the cytoplasm to the nucleus by norepinephrine, a process initiated by ADRB2/cAMP/protein kinase A activation. Norepinephrine 101-115 cathelicidin antimicrobial peptide Mus musculus 146-150 8897649-4 1996 Colocalization studies of tyrosine hydroxylase (TH) and Fos protein revealed that in the brainstem, 73 to 85% of noradrenaline-containing cells expressed Fos immunoreactivity. Norepinephrine 113-126 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 154-157 8670175-7 1996 In addition, experiments in vitro indicate that low millimolar amounts of either adrenaline (IC50 5.2 mM) or noradrenaline (IC50 2.4 mM) can significantly impair the proteolytic activity of recombinant murine prohormone convertase 1 when assayed with synthetic fluorogenic and/or peptidyl substrates. Norepinephrine 109-122 proprotein convertase subtilisin/kexin type 1 Mus musculus 209-232 32485758-6 2021 However, norepinephrine-induced vasoconstriction was substantially higher in aortic rings in CAF-treated male mice. Norepinephrine 9-23 caffeine susceptibility Mus musculus 93-96 8790927-1 1996 In addition to its direct vasoconstrictive effect, neuropeptide Y (NPY) potentiates noradrenaline-(NA) induced contraction and inhibits acetylcholine-(ACh) induced relaxation: The aim of the present study was to elucidate the NPY receptor subtypes responsible for mediating these three responses. Norepinephrine 84-97 pro-neuropeptide Y Cavia porcellus 51-65 32293507-0 2020 Norepinephrine-stimulated HSCs secrete sFRP1 to promote HCC progression following chronic stress via augmentation of a Wnt16B/beta-catenin positive feedback loop. Norepinephrine 0-14 secreted frizzled-related protein 1 Mus musculus 39-44 32293507-0 2020 Norepinephrine-stimulated HSCs secrete sFRP1 to promote HCC progression following chronic stress via augmentation of a Wnt16B/beta-catenin positive feedback loop. Norepinephrine 0-14 catenin (cadherin associated protein), beta 1 Mus musculus 126-138 8790927-1 1996 In addition to its direct vasoconstrictive effect, neuropeptide Y (NPY) potentiates noradrenaline-(NA) induced contraction and inhibits acetylcholine-(ACh) induced relaxation: The aim of the present study was to elucidate the NPY receptor subtypes responsible for mediating these three responses. Norepinephrine 84-97 pro-neuropeptide Y Cavia porcellus 67-70 8670061-12 1996 These results suggest that the mechanism by which noradrenaline stimulates glucose transport into brown adipocytes is not due to translocation of GLUT but is probably due to an increase in the intrinsic activity of GLUT, which is mediated by a cyclic AMP-dependent pathway. Norepinephrine 50-63 solute carrier family 2 member 1 Homo sapiens 215-219 32157301-8 2020 ApoA-IV increased sympathetic activity assessed by norepinephrine turnover (NETO) rate in BAT and EWAT of chow-fed mice, whereas it elevated NETO only in EWAT of HFD-fed mice. Norepinephrine 51-65 apolipoprotein A-IV Mus musculus 0-7 32098331-11 2020 This study also highlights the first association between ADRbeta2 signalling and LYPD3; its knockdown significantly reduced the basal and norepinephrine-induced activity of MCF-7 cells in vitro. Norepinephrine 138-152 adrenoceptor alpha 2A Homo sapiens 57-65 8648514-3 1996 A 0.1 ml bolus injection of 10(-5) M human adrenomedullin suppressed the pressor response of the canine tibia preparation to an infusion of norepinephrine by 43-52% for a duration of 100 minutes. Norepinephrine 140-154 adrenomedullin Homo sapiens 43-57 31941827-3 2020 Our results show that Abeta oligomers bind to an allosteric site on alpha2A adrenergic receptor (alpha2AAR) to redirect norepinephrine-elicited signaling to glycogen synthase kinase 3beta (GSK3beta) activation and tau hyperphosphorylation. Norepinephrine 120-134 adrenoceptor alpha 2A Homo sapiens 68-95 31941827-3 2020 Our results show that Abeta oligomers bind to an allosteric site on alpha2A adrenergic receptor (alpha2AAR) to redirect norepinephrine-elicited signaling to glycogen synthase kinase 3beta (GSK3beta) activation and tau hyperphosphorylation. Norepinephrine 120-134 adrenoceptor alpha 2A Homo sapiens 97-106 31793911-0 2020 Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus. Norepinephrine 0-14 legumain Homo sapiens 44-47 31771069-3 2020 Catechol-O-methyltransferase (COMT) and monoamine oxidase B (MAOB) are the enzymes that regulate degradation of dopamine, while dopamine beta-hydroxylase (DBH) is involved in synthesis of noradrenaline. Norepinephrine 188-201 monoamine oxidase B Homo sapiens 40-59 31771069-3 2020 Catechol-O-methyltransferase (COMT) and monoamine oxidase B (MAOB) are the enzymes that regulate degradation of dopamine, while dopamine beta-hydroxylase (DBH) is involved in synthesis of noradrenaline. Norepinephrine 188-201 monoamine oxidase B Homo sapiens 61-65 8648514-4 1996 An injection of 10(-6) adrenomedullin suppressed the pressor response to an infusion of norepinephrine by 22-23% for a duration of 40 minutes. Norepinephrine 88-102 adrenomedullin Homo sapiens 23-37 8549185-13 1996 Norepinephrine exhibits significant effects on the beta-receptors on lymphocytes, suggesting beta 2-adrenoceptor effects with high concentrations of this drug. Norepinephrine 0-14 adrenoceptor beta 2 Homo sapiens 93-112 31747589-2 2019 We find that ASL is prominently expressed in the nucleus locus coeruleus (LC), the central source of norepinephrine. Norepinephrine 101-115 argininosuccinate lyase Mus musculus 13-16 31356684-0 2019 STAT1-NFkappaB crosstalk triggered by interferon gamma regulates noradrenaline-induced pineal hormonal production. Norepinephrine 65-78 signal transducer and activator of transcription 1 Homo sapiens 0-5 8722501-3 1996 In human and guinea-pig isolated arteries alpha-trinositol potently (10 nM to 1 microM extracellular concentration) suppressed the constriction evoked by neuropeptide Y alone, the potentiation by neuropeptide Y of noradrenaline-evoked constriction, and the neuropeptide Y-induced inhibition of relaxation. Norepinephrine 214-227 pro-neuropeptide Y Cavia porcellus 196-210 31322231-3 2019 However, limited evidence of TPH alteration has been found in selective serotonin and noradrenaline reuptake inhibitors (SNRIs), and more key enzymes need to be investigated. Norepinephrine 86-99 tryptophan hydroxylase 1 Rattus norvegicus 29-32 31067439-7 2019 As noradrenaline has high potency at alpha1D-adrenceptors, these receptors mediate the fastest response and seem to be targets for neurally released noradrenaline especially to low frequency stimulation, with alpha1A-adrenoceptors being more important at high frequencies of stimulation. Norepinephrine 3-16 calcium voltage-gated channel subunit alpha1 A Homo sapiens 209-216 31067439-7 2019 As noradrenaline has high potency at alpha1D-adrenceptors, these receptors mediate the fastest response and seem to be targets for neurally released noradrenaline especially to low frequency stimulation, with alpha1A-adrenoceptors being more important at high frequencies of stimulation. Norepinephrine 149-162 calcium voltage-gated channel subunit alpha1 A Homo sapiens 209-216 31248037-0 2019 Norepinephrine Inhibits Synovial Adipose Stem Cell Chondrogenesis via alpha2a-Adrenoceptor-Mediated ERK1/2 Activation. Norepinephrine 0-14 adrenoceptor alpha 2A Homo sapiens 70-90 31396845-0 2019 Noradrenaline modulates CD4+ T cell priming in rat experimental autoimmune encephalomyelitis: a role for the alpha1-adrenoceptor. Norepinephrine 0-13 Cd4 molecule Rattus norvegicus 24-27 30920175-10 2019 CONCLUSIONS: The association of ENaC, Na-K-ATPase, and SGK1 expression with the cord blood norepinephrine concentration points to the importance of birth stress in promoting lung fluid clearance during early postnatal pulmonary adaptation. Norepinephrine 91-105 serum/glucocorticoid regulated kinase 1 Homo sapiens 55-59 30943999-5 2019 It was proposed that norepinephrine is released from Merkel cells upon mechanical stimulation to subsequently activate beta2 adrenergic receptors on Merkel disc nerve endings leading to nerve impulses. Norepinephrine 21-35 hemoglobin, beta adult minor chain Mus musculus 119-124 31657686-6 2019 RESULTS: Infusion of apelin into PVN of Wistar-Kyoto (WKY) rats induced chronic increases in systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), plasma norepinephrine (NE) level, maximal depressor response to hexamethonium (Hex), NAD(P)H oxidase activity, superoxide anions levels, and Nox4 expression. Norepinephrine 193-207 apelin Rattus norvegicus 21-27 30571558-0 2019 Norepinephrine-Induced Stimulation of Kir4.1/Kir5.1 Is Required for the Activation of NaCl Transporter in Distal Convoluted Tubule. Norepinephrine 0-14 potassium inwardly-rectifying channel, subfamily J, member 16 Mus musculus 45-51 30353660-5 2019 Mincle expression localized in microglia within the PVN was markedly increased at 24 hours post-MI together with sympathetic hyperactivity, as indicated by measurement of the renal sympathetic nerve activity (RSNA) and norepinephrine (NE) concentration. Norepinephrine 219-233 C-type lectin domain family 4, member E Rattus norvegicus 0-6 30126894-7 2018 In response to an increased norepinephrine (NE) level, expression of beta3-adrenoceptor was significantly upregulated, and the downstream protein kinase A (PKA) pathway was activated, as indicated by enhanced phosphorylation of whole PKA substrates, in particular, the hormone-sensitive lipase (HSL) in adipocytes. Norepinephrine 28-42 lipase, hormone sensitive Mus musculus 269-293 30126894-7 2018 In response to an increased norepinephrine (NE) level, expression of beta3-adrenoceptor was significantly upregulated, and the downstream protein kinase A (PKA) pathway was activated, as indicated by enhanced phosphorylation of whole PKA substrates, in particular, the hormone-sensitive lipase (HSL) in adipocytes. Norepinephrine 28-42 lipase, hormone sensitive Mus musculus 295-298 29478130-9 2018 Additionally, other neuroprotective actions of noradrenaline, such as the production of brain derived neurotrophic factor and the inhibition of the inducible nitric oxide synthase in astrocytes were modified by CCL2. Norepinephrine 47-60 brain-derived neurotrophic factor Rattus norvegicus 88-121 29900525-9 2018 Interestingly, the exchange protein directly activated by cAMP (Epac) agonist 8-pCPT-2"-O-Me-cAMP (50 muM) also up-regulated ICl.vol , and the noradrenaline-induced increase of ICl.vol in 0.6 T was reversed or prevented by the Epac inhibitor ESI-09 (10 muM). Norepinephrine 143-156 Rap guanine nucleotide exchange factor 3 Homo sapiens 64-68 29900525-9 2018 Interestingly, the exchange protein directly activated by cAMP (Epac) agonist 8-pCPT-2"-O-Me-cAMP (50 muM) also up-regulated ICl.vol , and the noradrenaline-induced increase of ICl.vol in 0.6 T was reversed or prevented by the Epac inhibitor ESI-09 (10 muM). Norepinephrine 143-156 Rap guanine nucleotide exchange factor 3 Homo sapiens 227-231 29900525-10 2018 CONCLUSION AND IMPLICATIONS: These data show that ICl.vol evoked by cell swelling of human atrial myocytes is up-regulated by noradrenaline via a PKA-independent cAMP/Epac pathway in human atrial myocytes. Norepinephrine 126-139 Rap guanine nucleotide exchange factor 3 Homo sapiens 167-171 29738736-4 2018 One such GR-independent mechanism involves corticosteroid-induced inhibition of monoamine transport mediated by "uptake2" transporters, including organic cation transporter 3 (OCT3), a low-affinity, high-capacity transporter for norepinephrine, epinephrine, dopamine, serotonin and histamine. Norepinephrine 229-243 OCTN3 Homo sapiens 146-174 29738736-4 2018 One such GR-independent mechanism involves corticosteroid-induced inhibition of monoamine transport mediated by "uptake2" transporters, including organic cation transporter 3 (OCT3), a low-affinity, high-capacity transporter for norepinephrine, epinephrine, dopamine, serotonin and histamine. Norepinephrine 229-243 OCTN3 Homo sapiens 176-180 8722501-3 1996 In human and guinea-pig isolated arteries alpha-trinositol potently (10 nM to 1 microM extracellular concentration) suppressed the constriction evoked by neuropeptide Y alone, the potentiation by neuropeptide Y of noradrenaline-evoked constriction, and the neuropeptide Y-induced inhibition of relaxation. Norepinephrine 214-227 pro-neuropeptide Y Cavia porcellus 196-210 8848120-7 1996 When incubating the organotypic hippocampal cultures with different concentrations of noradrenaline, nerve growth factor and brain-derived neurotrophic factor messenger RNAs but not neurotrophin-3 messenger RNA were significantly reduced in the dentate gyrus. Norepinephrine 86-99 brain-derived neurotrophic factor Rattus norvegicus 125-158 29084442-7 2018 Endocan concentration was correlated positively with renalase ( r = .2, P = .047) and norepinephrine ( r = .25, P = .02). Norepinephrine 86-100 endothelial cell specific molecule 1 Homo sapiens 0-7 8848120-8 1996 We conclude that nerve growth factor and brain-derived neurotrophic factor but not neurotrophin-3 expression are inhibited by noradrenaline, arising from the locus coeruleus. Norepinephrine 126-139 brain-derived neurotrophic factor Rattus norvegicus 41-74 29377263-4 2018 In the present study, we investigated the effects of adrenaline (AD) and norepinephrine (NE) on hepatic hepcidin regulation. Norepinephrine 73-87 hepcidin antimicrobial peptide Mus musculus 104-112 8565052-1 1995 In the present study we investigated whether norepinephrine, which stimulates melatonin biosynthesis in the mammalian pineal organ, causes phosphorylation of the cyclic AMP responsive element binding protein (CREB) in rat pinealocytes. Norepinephrine 45-59 cAMP responsive element binding protein 1 Homo sapiens 162-207 8565052-1 1995 In the present study we investigated whether norepinephrine, which stimulates melatonin biosynthesis in the mammalian pineal organ, causes phosphorylation of the cyclic AMP responsive element binding protein (CREB) in rat pinealocytes. Norepinephrine 45-59 cAMP responsive element binding protein 1 Homo sapiens 209-213 8633189-7 1995 The CD4/CD8 ratio and plasma norepinephrine were positively correlated (rs = 0.57, p = 0.037) and the major part of this correlation was due to a correlation between plasma norepinephrine and the percentage of CD4+ cells. Norepinephrine 173-187 CD8a molecule Homo sapiens 8-11 29658580-0 2018 Norepinephrine inhibits the cytotoxicity of NK92-MI cells via the beta2-adrenoceptor/cAMP/PKA/p-CREB signaling pathway. Norepinephrine 0-14 adrenoceptor beta 2 Homo sapiens 66-84 29658580-0 2018 Norepinephrine inhibits the cytotoxicity of NK92-MI cells via the beta2-adrenoceptor/cAMP/PKA/p-CREB signaling pathway. Norepinephrine 0-14 cAMP responsive element binding protein 1 Homo sapiens 96-100 8748977-0 1995 Norepinephrine induces expression of c-fos mRNA through the alpha-adrenoceptor in rat aortic rings. Norepinephrine 0-14 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 37-42 29524394-2 2018 The current study aimed to clarify the effects of single nucleotide polymorphisms (SNPs) of human SULT1A3 and SULT1A4 genes on the enzymatic characteristics of the sulfation of dopamine, epinephrine, norepinephrine and serotonin by SULT1A3 allozymes. Norepinephrine 200-214 sulfotransferase family 1A member 3 Homo sapiens 98-105 29329285-7 2018 We also provide evidence, from coarse grain MD simulations that the CHOL sites observed in the DAT crystal structures are preserved in all human monoamine transporters (dopamine, serotonin and norepinephrine), suggesting that our findings might extend to the entire family. Norepinephrine 193-207 solute carrier family 6 member 3 Homo sapiens 95-98 8748977-1 1995 We examined whether norepinephrine at pharmacologically relevant doses induces increased expression of c-fos mRNA in rat aortic rings. Norepinephrine 20-34 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 103-108 8748977-2 1995 c-fos mRNA was expressed at norepinephrine concentrations known to cause minimum and maximum contraction of rat aorta in vitro. Norepinephrine 28-42 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-5 8748977-3 1995 At the concentration known to cause maximum contraction, norepinephrine produced a marked and sustained increase of c-fos mRNA expression. Norepinephrine 57-71 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 116-121 28593564-3 2017 In this study, we treated H9c2 cardiac myoblasts with norepinephrine (NE, 2 microM), inducing ROS generation that was inhibited by Nox2-specific peptide inhibitor gp91ds-tat. Norepinephrine 54-68 cytochrome b-245 beta chain Homo sapiens 131-135 8748977-5 1995 A prazosin inhibition curve showed that 1 nmol/L prazosin inhibited 10 micromol/L norepinephrine induced c-fos expression by 40%. Norepinephrine 82-96 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 105-110 8748977-6 1995 At the pharmacologic dose known to cause maximum contraction, norepinephrine induces c-fos mRNA expression through the alpha-adrenoceptor in rat aortic rings. Norepinephrine 62-76 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 85-90 7657838-0 1995 Proadrenomedullin NH(2)-terminal 20 peptide, a new product of the adrenomedullin gene, inhibits norepinephrine overflow from nerve endings. Norepinephrine 96-110 adrenomedullin Rattus norvegicus 3-17 28830684-7 2017 In addition, the treatment of norepinephrine (NE) to in vitro cardiomyocytes increased Axud1 level and induced cell apoptosis. Norepinephrine 30-44 cysteine and serine rich nuclear protein 1 Rattus norvegicus 87-92 28645101-0 2017 Co-localization of endogenous Arf6 and its activator EFA6D in the granular convoluted tubule cells of mouse submandibular glands under normal conditions and when stimulated by isoproterenol, noradrenaline and carbachol. Norepinephrine 191-204 pleckstrin and Sec7 domain containing 3 Mus musculus 53-58 7657838-5 1995 In contrast, vasoconstrictive response of mesenteric arteries to exogenous norepinephrine was significantly attenuated by 10 pmol/ml of adrenomedullin but not by the same dose of PAMP. Norepinephrine 75-89 adrenomedullin Rattus norvegicus 136-150 7498270-0 1995 Platelet-activating factor-induced loss of vascular responsiveness to noradrenaline in pithed rats: involvement of nitric oxide. Norepinephrine 70-83 PCNA clamp associated factor Rattus norvegicus 0-26 7611494-3 1995 Des-Asp1-angiotensin I, angiotensin I, II, and III produced similar increases in perfusion pressure and were approximately 300-fold more potent than (p-amino-Phe6)-angiotensin II, 100-fold more potent than angiotensin IV, 30-fold more potent than norepinephrine, and 10-fold more potent than U-46619. Norepinephrine 247-261 beta-secretase 2 Homo sapiens 4-8 7737731-3 1995 During the first 60 minutes of norepinephrine infusion in control dogs, mean arterial pressure increased 9 +/- 4 mm Hg in association with a twofold to threefold rise in plasma renin activity. Norepinephrine 31-45 renin Canis lupus familiaris 177-182 27836486-1 2017 Vesicular monoamine transporter 2 (VMAT2, SLC18A2) is a transmembrane transporter protein that packages dopamine, serotonin, norepinephrine, and histamine into vesicles in preparation for neurotransmitter release from the presynaptic neuron. Norepinephrine 125-139 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 0-33 28887324-5 2017 Both epinephrine (EPI) and norepinephrine (NE) could directly inhibit breast cancer cell viability, as well as tumor growth in vivo EPI and NE activate the tumor suppressor Hippo signaling pathway, and the suppressive effect of exercise-conditioned serum was found to be mediated through phosphorylation and cytoplasmic retention of YAP and reduced expression of downstream target genes, for example, ANKRD1 and CTGF. Norepinephrine 27-41 ankyrin repeat domain 1 Homo sapiens 401-407 7623082-12 1995 Norepinephrine (< 0.5 mM) applied either to the injury site or the DRG increased the SA of most C fibers and A delta-fibers but only a minority of A beta-fibers in previously injured nerves. Norepinephrine 0-14 amyloid beta precursor protein Rattus norvegicus 150-156 28569366-15 2017 Since BPS/IC patients present high levels of noradrenaline, alpha 1A stimulation may be an additional trigger for bladder dysfunction presented by these patients. Norepinephrine 45-58 calcium voltage-gated channel subunit alpha1 A Homo sapiens 60-68 8574778-1 1995 Atrial natriuretic factor (ANF) effects on neuronal norepinephrine (NE) release evoked by angiotensin II (ANG II) or angiotensin III (ANG III) were studied in the rat adrenal medulla. Norepinephrine 52-66 natriuretic peptide A Rattus norvegicus 0-25 28472693-8 2017 In the CRH group, the total increase of sAA activity significantly correlated with noradrenaline release, indicating that sAA activity reflects pharmacologically induced sympathetic activation. Norepinephrine 83-96 amylase alpha 1A Homo sapiens 40-43 28438532-3 2017 The obtained results indicate that noradrenaline decreases the mean open probability of TREK-2-like channel currents by activation of beta1 but not of alpha1- and alpha2-adrenergic receptors. Norepinephrine 35-48 potassium two pore domain channel subfamily K member 10 Rattus norvegicus 88-94 28389717-5 2017 Selective blockade of beta1 (CGP20712) or beta3 (SR59230A), but not beta2 (ICI118,551) adrenoceptors, greatly increased alpha-adrenergic constriction (norepinephrine) of aorta in female SHRs, but not in male SHRs at 12 weeks of age. Norepinephrine 151-165 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 22-27 28116771-13 2017 Tensions following combined application of endothelin-2 or -3 with U46619 stayed below noradrenaline-induced contractions. Norepinephrine 87-100 endothelin 2 Homo sapiens 43-55 27237101-0 2017 Beta-adrenoceptor Activation by Norepinephrine Enhances Lipopolysaccharide-induced Matrix Metalloproteinase-9 Expression Through the ERK/JNK-c-Fos Pathway in Human THP-1 Cells. Norepinephrine 32-46 matrix metallopeptidase 9 Homo sapiens 83-109 8574778-1 1995 Atrial natriuretic factor (ANF) effects on neuronal norepinephrine (NE) release evoked by angiotensin II (ANG II) or angiotensin III (ANG III) were studied in the rat adrenal medulla. Norepinephrine 52-66 natriuretic peptide A Rattus norvegicus 27-30 27237101-0 2017 Beta-adrenoceptor Activation by Norepinephrine Enhances Lipopolysaccharide-induced Matrix Metalloproteinase-9 Expression Through the ERK/JNK-c-Fos Pathway in Human THP-1 Cells. Norepinephrine 32-46 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 141-146 8574778-1 1995 Atrial natriuretic factor (ANF) effects on neuronal norepinephrine (NE) release evoked by angiotensin II (ANG II) or angiotensin III (ANG III) were studied in the rat adrenal medulla. Norepinephrine 52-66 angiogenin Rattus norvegicus 106-109 7781701-2 1995 We investigated the effect of the cholinesterase inhibitor, MDL 73,745 (2,2,2-trifluoro-1-(3-trimethylsilylphenyl)ethanone), on the extracellular levels of acetylcholine, norepinephrine, dopamine and 5-hydroxytryptamine in the cerebral cortex of the rat by high-performance liquid chromatography coupled with electrochemical detection. Norepinephrine 171-185 butyrylcholinesterase Rattus norvegicus 34-48 7887963-2 1995 In aortic rings precontracted with 0.3 microM norepinephrine PTHrP(1-34) caused a dose-dependent relaxation with the maximal response of 33% being observed at 10(-6) M. PTHrP was nearly equipotent to PTH or CGRP in the vasodilatory action. Norepinephrine 46-60 parathyroid hormone-like hormone Rattus norvegicus 61-66 7887963-2 1995 In aortic rings precontracted with 0.3 microM norepinephrine PTHrP(1-34) caused a dose-dependent relaxation with the maximal response of 33% being observed at 10(-6) M. PTHrP was nearly equipotent to PTH or CGRP in the vasodilatory action. Norepinephrine 46-60 parathyroid hormone-like hormone Rattus norvegicus 169-174 8839228-2 1995 In norepinephrine-contracted arteries, ITF 296, NTG, and ISDN elicited maximal and concentration-dependent vasodilation with pD2 values of 7.07, 7.95, and 7.2, respectively. Norepinephrine 3-17 trefoil factor 3 Rattus norvegicus 39-42 8839228-5 1995 A time-dependent increase in cGMP content and a positive correlation between cGMP and vasodilation were observed in norepinephrine-contracted arteries after exposure to a single submaximal concentration of ITF 296 (1 microM). Norepinephrine 116-130 trefoil factor 3 Rattus norvegicus 206-209 7760370-1 1995 We have studied the effects of pressure and volume overload as well as of norepinephrine (NE) alone and in combination on the expression of the proto-oncogenes c-fos and c-myc in isolated perfused working rat hearts. Norepinephrine 74-88 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 160-165 7730990-13 1995 injection of CCK increased the concentrations in the dialysate of noradrenaline and serotonin, but not of either adrenaline or dopamine. Norepinephrine 66-79 cholecystokinin Rattus norvegicus 13-16 7730990-17 1995 Inclusion of morphine in the dialysate also blocked the increase in noradrenaline and serotonin in response to CCK in a naloxone-reversible manner. Norepinephrine 68-81 cholecystokinin Rattus norvegicus 111-114 7867036-7 1994 The response was time and concentration dependent with the maximal increase at 12 min, EC50 5.3 x 10(-9) M, and maximum effect at 10(-6) M. Both noradrenalin and endothelin-1 stimulated phosphatidylbutanol production in the presence of butanol (100 mM), indicating that both agonists activate phospholipase D. CONCLUSIONS: Noradrenaline at physiological concentrations elicits both a rapid and a delayed increase in phosphatidic acid in adult rabbit ventricular myocytes. Norepinephrine 323-336 endothelin-1 Oryctolagus cuniculus 162-174 7870311-12 1994 Many unspecific afferents to the cerebral cortex are potentially regulated by glucocorticoid receptors such as the noradrenaline and 5-hydroxytryptamine afferents, since their nerve cells of origin contain strong glucocorticoid receptor immunoreactivity. Norepinephrine 115-128 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 78-101 27694974-1 2016 Indatraline is an antidepressive agent and a non-selective monoamine transporter inhibitor that blocks the reuptake of neurotransmitters (dopamine, serotonin, and norepinephrine). Norepinephrine 163-177 solute carrier family 18 member A2 Rattus norvegicus 59-80 7983079-0 1994 Atrial natriuretic factor modifies noradrenaline release in a sodium-free medium. Norepinephrine 35-48 natriuretic peptide A Rattus norvegicus 0-25 27672365-11 2016 Sensitivity to beta1 and beta2-adrenoceptor stimulation was the same in EHT as in adult CM (-logEC50: 5.9 and 6.1 for norepinephrine (NE) and epinephrine (Epi), respectively), but very low concentrations of Rp-8-Br-cAMPS were sufficient to suppress effects (-logEC50: 5.3 and 5.3 respectively for NE and Epi). Norepinephrine 118-132 adrenoceptor beta 2 Homo sapiens 25-43 27452863-7 2016 Norepinephrine depresses aggrecans expression but stimulates MMP-3, MMP-13 and RANKL production by chondrocytes through ERK1/2 and PKA pathway; these effects were abolished by an alpha2A-adrenoreceptor antagonist. Norepinephrine 0-14 matrix metallopeptidase 3 Rattus norvegicus 61-66 27452863-7 2016 Norepinephrine depresses aggrecans expression but stimulates MMP-3, MMP-13 and RANKL production by chondrocytes through ERK1/2 and PKA pathway; these effects were abolished by an alpha2A-adrenoreceptor antagonist. Norepinephrine 0-14 matrix metallopeptidase 13 Rattus norvegicus 68-74 27301276-14 2016 It decreases the contractile response of (-)-noradrenaline through the alpha2B-AR subtype, blocks the function of alpha2A-AR subtype and alters the G protein coupling of these receptors, promoting a Gs-dependent pathway. Norepinephrine 41-58 adrenoceptor alpha 2B Rattus norvegicus 71-81 27043247-0 2016 Dysregulation of Norepinephrine Release in the Absence of Functional Synaptotagmin 7. Norepinephrine 17-31 synaptotagmin VII Mus musculus 69-84 27043247-1 2016 Synaptotagmin 7 (Syt7) is expressed in cardiac sympathetic nerve terminals where norepinephrine (NE) is released in both Ca(2+)-dependent exocytosis and Ca(2+)-independent norepinephrine transporter (NET)-mediated overflow. Norepinephrine 81-95 synaptotagmin VII Mus musculus 0-15 27043247-1 2016 Synaptotagmin 7 (Syt7) is expressed in cardiac sympathetic nerve terminals where norepinephrine (NE) is released in both Ca(2+)-dependent exocytosis and Ca(2+)-independent norepinephrine transporter (NET)-mediated overflow. Norepinephrine 81-95 synaptotagmin VII Mus musculus 17-21 8024626-4 1994 Norepinephrine (10(-9) mol/l) slightly, but not significantly, decreased the CRF-stimulated ANP release and did not change the basal ANP output. Norepinephrine 0-14 natriuretic peptide A Rattus norvegicus 92-95 26721188-8 2016 Stable depletion of SNAP-25 inhibited high-K(+)-induced noradrenaline secretion. Norepinephrine 56-69 synaptosome associated protein 25 Rattus norvegicus 20-27 26581245-10 2016 In vitro analyses indicated that norepinephrine-induced DUSP1 gene expression was mediated through ADRB2 activation of cAMP-PLC-PKC-CREB signaling, which inhibits JNK-mediated phosphorylation of c-Jun and protects ovarian cancer cells from apoptosis. Norepinephrine 33-47 adrenoceptor beta 2 Homo sapiens 99-104 26581245-10 2016 In vitro analyses indicated that norepinephrine-induced DUSP1 gene expression was mediated through ADRB2 activation of cAMP-PLC-PKC-CREB signaling, which inhibits JNK-mediated phosphorylation of c-Jun and protects ovarian cancer cells from apoptosis. Norepinephrine 33-47 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 195-200 26023064-2 2016 Neurons expressing the neuropeptide, relaxin-3 (RLN3), and its cognate receptor, RXFP3, constitute a putative "ascending arousal system", which shares neuroanatomical and functional similarities with serotonin (5-HT)/dorsal raphe and noradrenaline (NA)/locus coeruleus monoamine systems. Norepinephrine 234-247 relaxin 3 Mus musculus 37-46 26023064-2 2016 Neurons expressing the neuropeptide, relaxin-3 (RLN3), and its cognate receptor, RXFP3, constitute a putative "ascending arousal system", which shares neuroanatomical and functional similarities with serotonin (5-HT)/dorsal raphe and noradrenaline (NA)/locus coeruleus monoamine systems. Norepinephrine 234-247 relaxin 3 Mus musculus 48-52 26842107-2 2016 This paper describes the protocol for a randomised controlled trial (MIR) to investigate the extent to which the addition of the antidepressant mirtazapine is effective in reducing the symptoms of depression compared with placebo in patients who are still depressed after they have been treated with a selective serotonin reuptake inhibitor (SSRI) or serotonin and noradrenaline reuptake inhibitor (SNRI) for at least 6 weeks in primary care. Norepinephrine 365-378 membrane associated ring-CH-type finger 8 Homo sapiens 69-72 26787044-5 2016 However, sema 3A silencing leaded to sympathetic hyperinnervation, increased myocardial norepinephrine (NE) content and inducible VAs. Norepinephrine 88-102 semaphorin 3A Rattus norvegicus 9-16 26691781-1 2016 Previously we showed that activation of the Nucleus of the Solitary Tract (NTS)-Nucleus Paragigantocellularis (PGi)-Locus coeruleus (LC) pathway, which theoretically culminates with norepinephrine (NE) release in dorsal hippocampus (CA1 region) and basolateral amygdala (BLA) is necessary for the consolidation of object recognition (OR) memory. Norepinephrine 182-196 carbonic anhydrase 1 Homo sapiens 233-236 26536590-7 2015 Ang-(1-7) via Mas receptor also inhibited both Angiotensin II- and noradrenaline/norephinephrine-induced transactivation of ErbB2 and/or EGFR receptors. Norepinephrine 67-80 angiogenin Rattus norvegicus 0-8 26536590-7 2015 Ang-(1-7) via Mas receptor also inhibited both Angiotensin II- and noradrenaline/norephinephrine-induced transactivation of ErbB2 and/or EGFR receptors. Norepinephrine 67-80 erb-b2 receptor tyrosine kinase 2 Rattus norvegicus 124-129 26536590-7 2015 Ang-(1-7) via Mas receptor also inhibited both Angiotensin II- and noradrenaline/norephinephrine-induced transactivation of ErbB2 and/or EGFR receptors. Norepinephrine 67-80 epidermal growth factor receptor Rattus norvegicus 137-141 8190093-8 1994 A rise in the intracellular calcium concentration was nevertheless observed in transfected COS cells but was much smaller than that observed in response to norepinephrine in cells also expressing the alpha 1B-adrenergic receptor. Norepinephrine 156-170 adrenoceptor alpha 1B Homo sapiens 200-228 26503701-1 2015 The transporters for norepinephrine and dopamine (NET and DAT, respectively) constitute the molecular targets for recreational drugs and therapeutics used in the treatment of psychiatric disorders. Norepinephrine 21-35 solute carrier family 6 member 3 Homo sapiens 58-61 8032591-12 1994 In hD2-transfected cells, but not untransfected cells, high-threshold currents were depressed by quinpirole (30 +/- 4% at 100 nM; n = 15) with a pEC50 of 8.61 +/- 0.22 (n = 5), as well as by (-)-noradrenaline (28 +/- 5% at 1 microM, n = 9). Norepinephrine 191-208 immunoglobulin heavy diversity 2-15 Homo sapiens 3-6 26209364-8 2015 Together, these effects induced by psychostimulants, mediated through a non-dopamine transporter-mediated mechanism involving norepinephrine and the prefrontal cortex, may also contribute importantly to the reinforcing properties of these drugs. Norepinephrine 126-140 solute carrier family 6 member 3 Homo sapiens 76-96 26049402-7 2015 However, HFD-fed Glp1r-KO mice exhibited relatively less EE when housed at a cooler standard room temperature, and had relatively lower [Formula: see text] in response to a noradrenaline challenge, which is consistent with impaired BAT thermogenic capacity. Norepinephrine 173-186 glucagon-like peptide 1 receptor Mus musculus 17-22 25151968-0 2015 hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness. Norepinephrine 15-29 snail family transcriptional repressor 2 Homo sapiens 38-42 25617795-10 2015 These results indicate that the selective antagonism of alpha1A- and alpha1D-adrenoceptors results in antidepressant-like effects and that the alpha1B-subtype is the main target for the increased levels of noradrenaline caused by imipramine. Norepinephrine 206-219 calcium channel, voltage-dependent, N type, alpha 1B subunit Mus musculus 143-150 25437118-7 2015 In vitro, norepinephrine up-regulated expression of VEGF and IL-8 in sunitinib-treated cancer cells mainly through the beta-adrenoceptor-cAMP-PKA signaling pathway. Norepinephrine 10-24 vascular endothelial growth factor A Mus musculus 52-56 26630956-4 2015 Several FAAH or MAGL inhibitors are reported to have no cannabimimetic side effects and, therefore, are new potential therapeutic options for patients with MDD who are resistant to first-line antidepressants (selective serotonin and serotonin-norepinephrine reuptake inhibitors). Norepinephrine 243-257 monoglyceride lipase Homo sapiens 16-20 25304347-4 2015 To activate nuclear adrenergic receptors in adult cardiac myocytes, uptake of endogenous catecholamines epinephrine and norepinephrine occurs via organic cation transporter 3 (OCT3), a member of the slc22a family of genes. Norepinephrine 120-134 OCTN3 Homo sapiens 146-174 25304347-4 2015 To activate nuclear adrenergic receptors in adult cardiac myocytes, uptake of endogenous catecholamines epinephrine and norepinephrine occurs via organic cation transporter 3 (OCT3), a member of the slc22a family of genes. Norepinephrine 120-134 OCTN3 Homo sapiens 176-180 25002345-3 2014 It is observed that the combined infusion supplemented with norepinephrine brought about a lower mean pulmonary artery pressure; lower high-mobility group box 1 levels, pulmonary levels of interleukin-6, and arterial total nitrate/nitrite; lower apoptotic cells scores and total histological scores; but higher pulmonary gas exchange when compared with the separate infusion group and norepinephrine group. Norepinephrine 60-74 high mobility group box 1 Rattus norvegicus 135-160 25128931-0 2014 Norepinephrine infusion with and without alpha-adrenergic blockade by phentolamine increases salivary alpha amylase in healthy men. Norepinephrine 0-14 amylase alpha 1A Homo sapiens 93-115 25128931-2 2014 While stress-induced sAA increases correlate with norepinephrine (NE) secretion, a potential mediating role of noradrenergic mechanisms remains unclear. Norepinephrine 50-64 amylase alpha 1A Homo sapiens 21-24 8063046-4 1994 The noradrenaline resistance could be ascribed to a 10-fold decrease in lipolytic beta 2-adrenoceptor sensitivity (p < 0.01). Norepinephrine 4-17 adrenoceptor beta 2 Homo sapiens 82-101 8028022-3 1994 Activation of alpha 1-adrenergic receptors by norepinephrine (in the presence of propranolol) increased the rate of ANP secretion approximately two-fold (EC50 = 0.32 microM). Norepinephrine 46-60 natriuretic peptide A Rattus norvegicus 116-119 7905411-6 1994 Results with receptor-specific agonists and antagonists indicate that norepinephrine interacts with the beta 1-adrenergic receptor to stimulate cell proliferation. Norepinephrine 70-84 adrenergic receptor, beta 1 Mus musculus 104-130 7909482-0 1994 Release of acetylcholine and noradrenaline from the cholinergic and adrenergic afferents in rat hippocampal CA1, CA3 and dentate gyrus regions. Norepinephrine 29-42 carbonic anhydrase 3 Rattus norvegicus 113-116 8173946-16 1994 This suggests that NPY acts by decreasing noradrenaline release. Norepinephrine 42-55 neuropeptide Y Canis lupus familiaris 19-22 25049076-1 2014 The beta2-adrenergic receptor (beta2AR) is the prototypic member of G protein-coupled receptors (GPCRs) involved in the production of physiological responses to adrenaline and noradrenaline. Norepinephrine 176-189 adrenoceptor beta 2 Homo sapiens 4-29 8173946-18 1994 NPY increases acid secretion by decreasing tonic central adrenergic inhibition of acid by decreasing release of noradrenaline at a pre-synaptic level. Norepinephrine 112-125 neuropeptide Y Canis lupus familiaris 0-3 25049076-1 2014 The beta2-adrenergic receptor (beta2AR) is the prototypic member of G protein-coupled receptors (GPCRs) involved in the production of physiological responses to adrenaline and noradrenaline. Norepinephrine 176-189 adrenoceptor beta 2 Homo sapiens 31-38 8307150-5 1994 The order of affinity of the bovine VMAT2 transporter to substrates is: serotonin > dopamine = norepinephrine > epinephrine. Norepinephrine 98-112 solute carrier family 18 member A2 Rattus norvegicus 36-41 8149505-0 1994 Platelet activating factor impairs pressor responses to noradrenaline in the anaesthetized rat but does not mediate endotoxin-induced hyporeactivity. Norepinephrine 56-69 PCNA clamp associated factor Rattus norvegicus 0-26 24696080-15 2014 CONCLUSIONS: These findings indicate that, during stress, norepinephrine, via beta2-ARs, either directly or indirectly activates CRF-releasing neurons in the BNST that interface with motivational neurocircuitry to induce reinstatement of cocaine-conditioned reward. Norepinephrine 58-72 hemoglobin, beta adult minor chain Mus musculus 78-83 8149505-2 1994 Platelet activating factor (PAF, 50 ng kg-1 h-1) similarly impaired pressor responsiveness to noradrenaline, although this effect was accompanied by marked hypotension. Norepinephrine 94-107 PCNA clamp associated factor Rattus norvegicus 0-26 24614156-9 2014 Norepinephrine impaired keratinocyte migration; this effect was abrogated with B2AR-selective antagonist ICI-118,551 but not with B1AR-selective antagonist bisoprolol. Norepinephrine 0-14 adrenoceptor beta 2 Homo sapiens 79-83 8149505-2 1994 Platelet activating factor (PAF, 50 ng kg-1 h-1) similarly impaired pressor responsiveness to noradrenaline, although this effect was accompanied by marked hypotension. Norepinephrine 94-107 PCNA clamp associated factor Rattus norvegicus 28-31 24614156-10 2014 Finally, for clinical relevance, we determined that norepinephrine was present in freshly wounded skin, thus providing a potential mechanism for impaired healing by local B2AR activation in wound-edge keratinocytes. Norepinephrine 52-66 adrenoceptor beta 2 Homo sapiens 171-175 7927117-6 1994 The results are interpreted to suggest that alpha 1A-adrenoceptor subtype mediates noradrenaline-induced contractions of the guinea-pig aorta and that activation of alpha 1A-adrenoceptor subtype in the guinea-pig aorta is probably linked to intracellular Ca++ release. Norepinephrine 83-96 alpha-1A adrenergic receptor Cavia porcellus 44-65 24614156-12 2014 Norepinephrine appears to be a stress-related mediator that impairs keratinocyte migration through activation of the B2AR. Norepinephrine 0-14 adrenoceptor beta 2 Homo sapiens 117-121 7907100-10 1994 The pressor areas of the VLM and DM were DBH positive, indicating the presence of norepinephrine, while the dFTG-PVG and FTL were not. Norepinephrine 82-96 dopamine beta-hydroxylase Felis catus 41-44 7908124-3 1994 While CH-38083 and idazoxan, non-subtype selective alpha 2-adrenoceptor antagonists and BRL44408, a selective alpha 2A-adrenoceptor antagonist as well as WB4101 potentiated the lipolytic effect of noradrenaline, ARC-239, the selective alpha 2B-adrenoceptor antagonist failed to affect it. Norepinephrine 197-210 adrenoceptor alpha 2A Homo sapiens 110-131 8234284-5 1993 In the present experiments, microinjection of norepinephrine into the AV3V region induced natriuresis and an increase in plasma ANP. Norepinephrine 46-60 natriuretic peptide A Rattus norvegicus 128-131 25006259-7 2014 A crystal structure of the beta2-adrenoreceptor in complex with a covalent noradrenaline analog and a conformationally selective antibody (nanobody) verified that these agonists can be used to facilitate crystallogenesis. Norepinephrine 75-88 adrenoceptor beta 2 Homo sapiens 27-47 24777478-5 2014 We demonstrate that norepinephrine acts through alpha1-adrenergic receptors to increase cytoplasmic Ca(2+), activating calcineurin and promoting migration of the fission protein Drp1 (encoded by Dnml1) to mitochondria. Norepinephrine 20-34 dynamin 1-like Rattus norvegicus 178-182 24777478-5 2014 We demonstrate that norepinephrine acts through alpha1-adrenergic receptors to increase cytoplasmic Ca(2+), activating calcineurin and promoting migration of the fission protein Drp1 (encoded by Dnml1) to mitochondria. Norepinephrine 20-34 dynamin 1-like Rattus norvegicus 195-200 24777478-6 2014 Dominant-negative Drp1 (K38A) not only prevented mitochondrial fission, it also blocked hypertrophic growth of cardiomyocytes in response to norepinephrine. Norepinephrine 141-155 dynamin 1-like Rattus norvegicus 18-22 24629015-6 2014 Ninety days after MI both WT and beta2 KO mice presented to cardiac dysfunction and remodelling accompanied by significantly increased norepinephrine and epinephrine plasma levels, exercise intolerance, changes towards more glycolytic fibres and vascular rarefaction in plantaris muscle. Norepinephrine 135-149 hemoglobin, beta adult minor chain Mus musculus 33-38 24451568-0 2014 Pharmacological characterization of BDNF promoters I, II and IV reveals that serotonin and norepinephrine input is sufficient for transcription activation. Norepinephrine 91-105 brain-derived neurotrophic factor Rattus norvegicus 36-40 7902002-5 1993 Insulin infusion resulted in hyperinsulinemic-hypoglycemia, a surge in epinephrine and norepinephrine concentration, and increases in the combined ventricular output and regional blood flow to the heart, adrenal glands, kidney, gastrointestinal tract, liver, fat, muscle, carcass, and placenta. Norepinephrine 87-101 LOC105613195 Ovis aries 0-7 24384038-9 2014 The selective sigma1 receptor antagonist S1RA results in inhibition of formalin-evoked Glu release, no modification of GABA levels, and enhancement of noradrenaline (NA) levels. Norepinephrine 151-164 sigma non-opioid intracellular receptor 1 Rattus norvegicus 14-29 24706871-1 2014 Galanin is a stress-inducible neuropeptide and cotransmitter in serotonin and norepinephrine neurons with a possible role in stress-related disorders. Norepinephrine 78-92 galanin and GMAP prepropeptide Homo sapiens 0-7 24553185-5 2014 Norepinephrine (NE) reduced the nAChR currents, an effect partially mimicked by a beta-adrenergic receptor agonist, isoproterenol, and blocked by a beta-adrenergic receptor antagonist, propranolol. Norepinephrine 0-14 cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus 32-37 24554716-0 2014 Growth differentiation factor (GDF)-15 blocks norepinephrine-induced myocardial hypertrophy via a novel pathway involving inhibition of epidermal growth factor receptor transactivation. Norepinephrine 46-60 growth differentiation factor 15 Homo sapiens 0-38 24554716-3 2014 In this present study, we demonstrate that GDF-15 blocks norepinephrine (NE)-induced myocardial hypertrophy through a novel pathway involving inhibition of EGFR transactivation. Norepinephrine 57-71 growth differentiation factor 15 Homo sapiens 43-49 8263948-8 1993 These results lend further support to the notion that Fos and related gene products mediate some of the hypertrophic actions of norepinephrine. Norepinephrine 128-142 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 54-57 8232276-2 1993 In the present work, we studied the effect of AdoMet on norepinephrine (NE)-stimulated inositol phosphate production in 3H-inositol-labelled crude synaptosomal suspensions of rat brain. Norepinephrine 56-70 methionine adenosyltransferase 1A Rattus norvegicus 46-52 7686534-0 1993 Potentiation of norepinephrine-induced contractions by endothelin-1 in the rabbit aorta. Norepinephrine 16-30 endothelin-1 Oryctolagus cuniculus 55-67 7686534-1 1993 Subthreshold concentrations of endothelin-1 potentiated the norepinephrine-induced contraction in isometrically mounted rings of the rabbit aorta. Norepinephrine 60-74 endothelin-1 Oryctolagus cuniculus 31-43 7686534-2 1993 Pretreatment with endothelin-1 (0.1 nM) for 10 minutes increased the sensitivity of the aortic rings to norepinephrine without affecting the maximal contraction. Norepinephrine 104-118 endothelin-1 Oryctolagus cuniculus 18-30 7686534-7 1993 We conclude that endothelin-1 potentiation of the norepinephrine-induced contraction occurs in the absence of changes in stimulated Ca2+ entry and is endothelium independent. Norepinephrine 50-64 endothelin-1 Oryctolagus cuniculus 17-29 7689357-0 1993 Atrial natriuretic peptide and bradykinin interaction on norepinephrine uptake in rat adrenal medulla. Norepinephrine 57-71 natriuretic peptide A Rattus norvegicus 0-26 7689357-1 1993 Interactions between atrial natriuretic peptide (ANP) and bradykinin (BDK) on norepinephrine (NE) uptake were demonstrated in the adrenal medulla of the rat. Norepinephrine 78-92 natriuretic peptide A Rattus norvegicus 21-47 1436127-8 1992 The time-course of the development of changes in CCK-8 binding paralleled with some lag the development of changes in noradrenaline uptake. Norepinephrine 118-131 cholecystokinin Rattus norvegicus 49-52 1422575-3 1992 Here we examine the effect of various agonists and antagonists of 5-HT2/5-HT1C receptors on noradrenaline release in hippocampus of anaesthetized rats using microdialysis. Norepinephrine 92-105 5-hydroxytryptamine receptor 2C Rattus norvegicus 72-78 24877149-2 2014 In the rodent, Aanat gene expression displays a marked circadian rhythm; release of norepinephrine in the gland at night causes a cAMP-based induction of Aanat transcription. Norepinephrine 84-98 aralkylamine N-acetyltransferase Homo sapiens 154-159 24670922-5 2014 In synthesis, norepinephrine downregulated levels of mRNA for type I to type III collagen in ratio, but increased the elastin gene transcription and glycosaminoglycan levels in valve interstitial cells greatly. Norepinephrine 14-28 elastin Homo sapiens 118-125 24670922-7 2014 Diminished MMP inhibitor expression, TIMP2, also could reflect this effect in the norepinephrine medium. Norepinephrine 82-96 TIMP metallopeptidase inhibitor 2 Homo sapiens 37-42 24189139-0 2014 Role of calcium and EPAC in norepinephrine-induced ghrelin secretion. Norepinephrine 28-42 Rap guanine nucleotide exchange factor 3 Homo sapiens 20-24 24144187-3 2013 Herein, the interaction of Ngb with the quinones generated by oxidation of catecholamines (dopamine, norepinephrine) and catechol estrogens (2-hydroxyestradiol and 4-hydroxyestradiol), which have been implicated in neurodegenerative pathologies like Parkinson"s and Alzheimer"s diseases, has been investigated. Norepinephrine 101-115 neuroglobin Homo sapiens 27-30 23978467-4 2013 The noradrenaline that is recruited by the action of the antidepressants on reuptake transporters has been proposed to act through beta2-adrenoceptors (beta2-ARs) to lead to the observed therapeutic effect. Norepinephrine 4-17 hemoglobin, beta adult minor chain Mus musculus 131-136 23978467-4 2013 The noradrenaline that is recruited by the action of the antidepressants on reuptake transporters has been proposed to act through beta2-adrenoceptors (beta2-ARs) to lead to the observed therapeutic effect. Norepinephrine 4-17 hemoglobin, beta adult minor chain Mus musculus 152-157 23978467-8 2013 More particularly, we report that antidepressant-recruited noradrenaline acts, within dorsal root ganglia, on beta2-ARs expressed by non-neuronal satellite cells. Norepinephrine 59-72 hemoglobin, beta adult minor chain Mus musculus 110-115 24010080-3 2013 There is a close association between salivary alpha amylase and plasma norepinephrine under stressful physical conditions. Norepinephrine 71-85 amylase alpha 1A Homo sapiens 37-59 23806689-2 2013 We previously reported that noradrenaline (NA) suppressed K(+) currents via Gi/o protein-coupled alpha1B-adrenergic receptor (alpha1B-AR) in human osteoblast SaM-1 cells. Norepinephrine 28-41 adrenoceptor alpha 1B Homo sapiens 97-124 23806689-2 2013 We previously reported that noradrenaline (NA) suppressed K(+) currents via Gi/o protein-coupled alpha1B-adrenergic receptor (alpha1B-AR) in human osteoblast SaM-1 cells. Norepinephrine 28-41 adrenoceptor alpha 1B Homo sapiens 126-136 23742775-16 2013 Norepinephrine significantly increased the activity of ROCK-1 in normal rats but not in cirrhotic ones. Norepinephrine 0-14 Rho-associated coiled-coil containing protein kinase 1 Rattus norvegicus 55-61 23742775-17 2013 Norepinephrine significantly increased ROCK-1 activity in cirrhotic rats when GRK-2 inhibitor was used. Norepinephrine 0-14 Rho-associated coiled-coil containing protein kinase 1 Rattus norvegicus 39-45 1422575-8 1992 The effect of DOI on noradrenaline output was prevented by pretreatment with the 5-HT2/5-HT1C receptor antagonist, ritanserin (0.4 mg kg-1, s.c.). Norepinephrine 21-34 5-hydroxytryptamine receptor 2C Rattus norvegicus 87-93 1327420-7 1992 Additionally, the effect of norepinephrine on the phosphorylation of GFAP and vimentin was blocked by alprenolol. Norepinephrine 28-42 glial fibrillary acidic protein Rattus norvegicus 69-73 1279289-4 1992 beta 1-Adrenoceptor-mediated effects were isoprenaline (ISO) infusion-induced increase in systolic blood pressure (SBP) and bicycle exercise-induced increase in heart rate (HR); beta 2-adrenoceptor-mediated effects were ISO infusion-induced increase in plasma norepinephrine (NE) and decrease in diastolic blood pressure (DBP); ISO infusion-induced increase in HR was assessed as mixed beta 1- and beta 2-adrenoceptor-mediated effect. Norepinephrine 260-274 adrenoceptor beta 2 Homo sapiens 178-197 1279294-6 1992 Thus, NPY, which is colocalized not only with norepinephrine in sympathetic perivascular fibers but also with VIP and ACh in some parasympathetic neurons, can greatly reduce the vasodilatory effect of ACh and VIP, as well as of the sensory peptide SP. Norepinephrine 46-60 pro-neuropeptide Y Cavia porcellus 6-9 1301634-0 1992 Effects of atrial natriuretic peptide, angiotensin II and III on norepinephrine uptake in the rat adrenal medulla. Norepinephrine 65-79 natriuretic peptide A Rattus norvegicus 11-37 1300039-2 1992 NPY microinjection (1.5 micrograms) also produced marked decreases in noradrenaline (5 +/- 4 pmol.ml-1) and adrenaline (23 +/- 8 pmol.ml-1), but no significant change in dopamine in blood plasma. Norepinephrine 70-83 neuropeptide Y Felis catus 0-3 1300039-3 1992 The results suggest that the depressor effect of NPY in A1 noradrenergic nucleus may be realized by not only reducing the release of noradrenaline in sympathetic terminals around the peripheral vascular beds but also inhibiting the sympathetico-adrenal system. Norepinephrine 133-146 neuropeptide Y Felis catus 49-52 1324861-6 1992 Angiotensin II (100 nmol/l) and norepinephrine (1 mumol/l) evoked marked increases in (Na+,K+)-ATPase activity in aortic intima-media incubated with 5 mmol/l glucose and 70 mumol/l myo-inositol, which were inhibited when adenosine deaminase was added or the medium myo-inositol omitted to inhibit myo-inositol transport. Norepinephrine 32-46 adenosine deaminase Oryctolagus cuniculus 221-240 1325876-2 1992 Stimulation of the adult gland with norepinephrine elevates both cyclic AMP and cyclic GMP production, through remarkably similar mechanisms requiring activation of both beta- and alpha 1-adrenergic receptors. Norepinephrine 36-50 5'-nucleotidase, cytosolic II Homo sapiens 87-90 1353301-9 1992 These results indicate that the inhibitory effects exerted by the sympathetic nervous system on insulin secretion are mediated not only by the classical neurotransmitter norepinephrine acting on alpha 2-adrenoceptors but also by a nonadrenergic cotransmitter that can maintain transmission under conditions of catecholamine deficiency. Norepinephrine 170-184 insulin Canis lupus familiaris 96-103 23609393-7 2013 After medication, increasing possession of a G allele at the MspI polymorphism of the ADRA2A gene was associated with increased MPH-related change in response time variability in the flanker task (P = 1.0 x 10).Our study suggested an association between norepinephrine gene variants and response time variability measured at baseline and after MPH treatment in children with ADHD. Norepinephrine 254-268 adrenoceptor alpha 2A Homo sapiens 86-92 23672601-6 2013 We also show here that Slc6a17mRNA is up-regulated in animals subjected to short term food deprivation as well as animals treated with the serotonin reuptake inhibitor fluoxetine and the dopamine/noradrenaline reuptake inhibitor bupropion. Norepinephrine 196-209 solute carrier family 6 member 17 Rattus norvegicus 23-30 23061915-7 2013 KEY RESULTS: In SaM-1 cells, bath-applied noradrenaline elevated intracellular Ca(2+) concentration and this effect was abolished by both chloroethylclonidine, an alpha(1B) -adrenoceptor antagonist, and U73122, a PLC inhibitor. Norepinephrine 42-55 adrenoceptor alpha 1B Homo sapiens 164-187 23303344-10 2013 Treatment with norepinephrine bitartrate stimulated Vegf messenger RNA expression and protein secretion in ChECs and RPE cells. Norepinephrine 15-29 vascular endothelial growth factor A Mus musculus 52-56 23302980-12 2013 CONCLUSIONS: This study provides evidence that anandamide and PEA induce peripheral antinociception activating CB1 and CB2 cannabinoid receptors, respectively, stimulating an endogenous norepinephrine release that activates peripheral adrenoceptors inducing antinociception. Norepinephrine 186-200 cannabinoid receptor 1 Rattus norvegicus 111-114 22508464-0 2013 Increased vulnerability of the brain norepinephrine system of females to corticotropin-releasing factor overexpression. Norepinephrine 37-51 corticotropin releasing hormone Mus musculus 73-103 23011268-3 2013 First, we found reduced levels of dopamine, serotonin and norepinephrine in the nucleus accumbens (NAC) of DISC1-Q31L mutants. Norepinephrine 58-72 disrupted in schizophrenia 1 Mus musculus 107-112 23524625-1 2013 OBJECTIVES: We previously demonstrated that the direct microinjection of cholinesterase inhibitor (neostigmine) into the hippocampus in rats activated the hypothalamo-pituitary -adrenal axis and increased the level of norepinephrine in the plasma. Norepinephrine 218-232 butyrylcholinesterase Rattus norvegicus 73-87 22923471-7 2012 Moreover, L-PGDS knockout mice exhibited increased expression of genes involved in thermogenesis and increased norepinephrine-stimulated glucose uptake to BAT, suggesting that sympathetically mediated changes in glucose uptake may have improved glucose tolerance. Norepinephrine 111-125 prostaglandin D2 synthase (brain) Mus musculus 10-16 26593027-1 2012 Monoamine oxidase (MAO), which exists in two isozymic forms, MAO A and MAO B, is an important flavoenzyme responsible for the metabolism of amine neurotransmitters such as dopamine, serotonin, and norepinephrine. Norepinephrine 197-211 monoamine oxidase B Homo sapiens 71-76 22996798-2 2012 CE with LIF detection for the determination of FITC derivatized catecholamines (dopamine, epinephrine, and norepinephrine) was demonstrated. Norepinephrine 107-121 LIF, interleukin 6 family cytokine Rattus norvegicus 8-11 22722024-0 2012 Presynaptic alpha2-adrenoceptors control the inhibitory action of presynaptic CB1 cannabinoid receptors on prefrontocortical norepinephrine release in the rat. Norepinephrine 125-139 cannabinoid receptor 1 Rattus norvegicus 78-81 22723268-7 2012 Intriguingly, not only ACTH, but also norepinephrine stimulated lipolysis were substantially reduced demonstrating functional significance of MC2R for general lipolysis pathway. Norepinephrine 38-52 melanocortin 2 receptor Mus musculus 142-146 1593712-4 1992 At 60 minutes, the mean increases in 3H-inositol inositol phosphates induced by 3 x 10(-7) M endothelin-1 and 10(-3) M noradrenaline amounted to 341 and 530% of time-matched controls, respectively. Norepinephrine 119-132 endothelin-1 Oryctolagus cuniculus 93-112 1377629-0 1992 Modulation of hypothalamic norepinephrine release by atrial natriuretic peptide: involvement of cyclic GMP. Norepinephrine 27-41 natriuretic peptide A Rattus norvegicus 53-79 1372289-2 1992 We have postulated that atrial natriuretic peptide inhibits norepinephrine release in anterior hypothalamus, reducing excitation of sympathoinhibitory neurons, increasing sympathetic outflow, and elevating blood pressure in this model. Norepinephrine 60-74 natriuretic peptide A Rattus norvegicus 24-50 1322821-8 1992 Associated with the decreased choline acetyltransferase activity after 1 week was an enhanced phosphoinositide hydrolysis in response to norepinephrine, and after 2 weeks there were enhanced responses to norepinephrine and to ibotenate. Norepinephrine 137-151 choline O-acetyltransferase Rattus norvegicus 30-55 22752240-1 2012 Norepinephrine transporter (NET) regulates noradrenergic synaptic transmission by controlling extracellular levels of norepinephrine (NE). Norepinephrine 118-132 solute carrier family 6 member 2 Bos taurus 0-26 22513004-6 2012 Functional studies, conducted primarily on lipocalin 2 (Lcn2), the mouse homologue of human NGAL have revealed that Lcn2 has a strong affinity for iron complexed to both bacterial siderophores (iron-binding proteins) and certain human proteins like norepinephrine. Norepinephrine 249-263 lipocalin 2 Homo sapiens 92-96 22513004-6 2012 Functional studies, conducted primarily on lipocalin 2 (Lcn2), the mouse homologue of human NGAL have revealed that Lcn2 has a strong affinity for iron complexed to both bacterial siderophores (iron-binding proteins) and certain human proteins like norepinephrine. Norepinephrine 249-263 lipocalin 2 Homo sapiens 116-120 22441984-7 2012 Accordingly, norepinephrine-induced ROS production, promoter methylation, and PKCepsilon gene repression were completely abrogated by knockdown of Nox1 in cardiomyocytes. Norepinephrine 13-27 NADPH oxidase 1 Rattus norvegicus 147-151 22441984-8 2012 These findings provide evidence of a novel interaction between elevated norepinephrine and epigenetic repression of PKCepsilon gene in the heart mediated by Nox1-dependent oxidative stress and suggest new insights of molecular mechanisms linking the heightened sympathetic activity to aberrant cardioprotection and increased ischemic vulnerability in the heart. Norepinephrine 72-86 NADPH oxidase 1 Rattus norvegicus 157-161 23487485-1 2012 Our previous study showed a significant relationships between static exercise-induced changes in plasma adrenomedullin (ADM) and those in endothelin-1 (ET-1), noradrenaline (NA) and pre-ejection period/left ventricular ejection time ratio (PEP/LVET) in older healthy men. Norepinephrine 159-172 adrenomedullin Homo sapiens 104-118 22379120-5 2012 To examine the effects of increasing concentrations of the endogenous agonist norepinephrine on the speed and extent of alpha(2A)-AR activation with very high temporal resolution, we took advantage of a fluorophore-containing alpha(2A)-AR sensor. Norepinephrine 78-92 adrenoceptor alpha 2A Homo sapiens 120-132 22379120-5 2012 To examine the effects of increasing concentrations of the endogenous agonist norepinephrine on the speed and extent of alpha(2A)-AR activation with very high temporal resolution, we took advantage of a fluorophore-containing alpha(2A)-AR sensor. Norepinephrine 78-92 adrenoceptor alpha 2A Homo sapiens 226-238 22379120-8 2012 To analyze the ability of norepinephrine to trigger a downstream intracellular response after alpha(2A)-AR stimulation, we monitored the kinetics and amplitude of G(i) activation in real time by using a fluorophore-containing G(i) sensor. Norepinephrine 26-40 adrenoceptor alpha 2A Homo sapiens 94-106 22318196-8 2012 In cultured hippocampal neurons, application of serotonin or norepinephrine (10-50 muM) induced increase in synaptic transmission and targeting of BDNF mRNA in dendrites. Norepinephrine 61-75 brain derived neurotrophic factor Homo sapiens 147-151 22538810-1 2012 Parathyroid hormone (PTH), the major calcium-regulating hormone, and norepinephrine (NE), the principal neurotransmitter of sympathetic nerves, regulate bone remodeling by activating distinct cell-surface G protein-coupled receptors in osteoblasts: the parathyroid hormone type 1 receptor (PTHR) and the beta(2)-adrenergic receptor (beta(2)AR), respectively. Norepinephrine 69-83 parathyroid hormone 1 receptor Mus musculus 290-294 1322821-8 1992 Associated with the decreased choline acetyltransferase activity after 1 week was an enhanced phosphoinositide hydrolysis in response to norepinephrine, and after 2 weeks there were enhanced responses to norepinephrine and to ibotenate. Norepinephrine 204-218 choline O-acetyltransferase Rattus norvegicus 30-55 1545496-4 1992 These results indicate that the actions of PGD2 depend upon serotonin and norepinephrine systems. Norepinephrine 74-88 prostaglandin D2 synthase (brain) Mus musculus 43-47 1657022-5 1991 On stimulation with the secretagogue noradrenaline, CRH(1-41) was released into the medium, while the precursor was not. Norepinephrine 37-50 corticotropin releasing hormone Mus musculus 52-55 1957706-3 1991 In contrast, calcitonin gene-related peptide elicited a concentration-dependent and pronounced (78-99%) relaxation of vesical arteries precontracted with endothelin-1, noradrenaline or prostaglandin F2 alpha. Norepinephrine 168-181 Calcitonin gene-related peptide Sus scrofa 13-44 1716066-1 1991 Norepinephrine and four families of neuropeptides, namely, neuropeptide Y (NPY), opioid peptides, galanin, and growth hormone-releasing factor (GRH), have been shown to stimulate feeding after central administration. Norepinephrine 0-14 neuropeptide Y Canis lupus familiaris 59-73 1716066-1 1991 Norepinephrine and four families of neuropeptides, namely, neuropeptide Y (NPY), opioid peptides, galanin, and growth hormone-releasing factor (GRH), have been shown to stimulate feeding after central administration. Norepinephrine 0-14 neuropeptide Y Canis lupus familiaris 75-78 1816758-3 1991 Endothelin-2 (10(-11)-10(-7) M) evoked a dose-dependent contractile response, having the same efficacy as noradrenaline and 100 times its potency. Norepinephrine 106-119 endothelin 2 Homo sapiens 0-12 23429762-1 2012 OBJECTIVE: This study examined the association between the brain-derived neurotrophic factor (BDNF) (Val66Met) polymorphism and the response to the addition of an atypical antipsychotic drug to a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) in treatment-refractory depression. Norepinephrine 255-269 brain derived neurotrophic factor Homo sapiens 59-92 23429762-1 2012 OBJECTIVE: This study examined the association between the brain-derived neurotrophic factor (BDNF) (Val66Met) polymorphism and the response to the addition of an atypical antipsychotic drug to a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) in treatment-refractory depression. Norepinephrine 255-269 brain derived neurotrophic factor Homo sapiens 94-98 22398028-0 2012 Norepinephrine suppresses IFN-gamma and TNF-alpha production by murine intestinal intraepithelial lymphocytes via the beta1 adrenoceptor. Norepinephrine 0-14 adrenergic receptor, beta 1 Mus musculus 118-136 1835717-5 1991 Noradrenaline-stimulated lipolysis was most effectively inhibited by small quantities of insulin in these depots. Norepinephrine 0-13 insulin Cavia porcellus 89-96 1835717-8 1991 Noradrenaline-stimulated lipolysis was more effectively inhibited by 100 muunit/ml insulin in adipocytes from the mesenteric and omental depot in those from any other site. Norepinephrine 0-13 insulin Cavia porcellus 83-90 1659347-1 1991 Neuropeptide Y (NPY) is coreleased with noradrenaline (NA) from sympathetic nerve endings. Norepinephrine 40-53 neuropeptide Y Canis lupus familiaris 0-14 1659347-1 1991 Neuropeptide Y (NPY) is coreleased with noradrenaline (NA) from sympathetic nerve endings. Norepinephrine 40-53 neuropeptide Y Canis lupus familiaris 16-19 1654268-0 1991 Alpha 2A- and alpha 2C-adrenoceptor subtypes are differentially down-regulated by norepinephrine. Norepinephrine 82-96 adrenoceptor alpha 2A Homo sapiens 0-35 1907104-2 1991 Intrarenal infusion of C16-PAF at hypotensive (2.5 ng.min-1.kg-1) or nonhypotensive (0.5 ng.min-1.kg-1) doses caused renal vasodilation and dose dependently antagonized the renal vasoconstrictor responses of intrarenal boluses of angiotensin II (ANG II) greater than norepinephrine (NE) greater than vasopressin (AVP). Norepinephrine 267-281 PCNA clamp associated factor Rattus norvegicus 27-30 22127496-0 2012 Norepinephrine promotes the beta1-integrin-mediated adhesion of MDA-MB-231 cells to vascular endothelium by the induction of a GROalpha release. Norepinephrine 0-14 integrin subunit beta 1 Homo sapiens 28-42 22127496-0 2012 Norepinephrine promotes the beta1-integrin-mediated adhesion of MDA-MB-231 cells to vascular endothelium by the induction of a GROalpha release. Norepinephrine 0-14 C-X-C motif chemokine ligand 1 Homo sapiens 127-135 22127496-4 2012 The adhesion of MDA-MB-231 cells was based on a norepinephrine-mediated release of GROalpha from HMVECs. Norepinephrine 48-62 C-X-C motif chemokine ligand 1 Homo sapiens 83-91 22219298-7 2012 Noradrenaline and dopamine enhanced LTP induction in STX1A(-/-) mice, whereas catecholamine depletion reduced LTP induction in wild-type mice. Norepinephrine 0-13 syntaxin 1A (brain) Mus musculus 53-58 23507624-2 2012 Norepinephrine (NE) release due to sympathetic activation leads to a Th2 deviation via the beta-2 adrenergic receptor Beta-2 adrenergic receptor (beta-2AR) and could increase cancer progression. Norepinephrine 0-14 adrenoceptor beta 2 Homo sapiens 91-117 23507624-2 2012 Norepinephrine (NE) release due to sympathetic activation leads to a Th2 deviation via the beta-2 adrenergic receptor Beta-2 adrenergic receptor (beta-2AR) and could increase cancer progression. Norepinephrine 0-14 adrenoceptor beta 2 Homo sapiens 118-144 23507624-2 2012 Norepinephrine (NE) release due to sympathetic activation leads to a Th2 deviation via the beta-2 adrenergic receptor Beta-2 adrenergic receptor (beta-2AR) and could increase cancer progression. Norepinephrine 0-14 adrenoceptor beta 2 Homo sapiens 146-154 22116378-9 2012 The manipulation of the noradrenaline activity was confirmed by salivary alpha-amylase (sAA) samples taken pre-, during and post-exposure. Norepinephrine 24-37 amylase alpha 1A Homo sapiens 64-86 22116378-9 2012 The manipulation of the noradrenaline activity was confirmed by salivary alpha-amylase (sAA) samples taken pre-, during and post-exposure. Norepinephrine 24-37 amylase alpha 1A Homo sapiens 88-91 22116378-11 2012 Manipulation of noradrenaline levels with YOH was successful, with significantly higher levels of sAA in the YOH group when entering exposure. Norepinephrine 16-29 amylase alpha 1A Homo sapiens 98-101 2072294-10 1991 These findings indicate that endogenous opioids regulate the effects of norepinephrine in the CA3 region of the guinea pig hippocampus. Norepinephrine 72-86 carbonic anhydrase 3 Cavia porcellus 94-97 2072294-11 1991 In addition, endogenously released norepinephrine appeared to act on GABAergic interneurons to increase the amplitude of the IPSP recorded in CA3 pyramidal cells. Norepinephrine 35-49 carbonic anhydrase 3 Cavia porcellus 142-145 1685558-14 1991 Consistent with this finding, around 80% of the adenylyl cyclase stimulation by both (-)-noradrenaline and (-)-adrenaline was mediated through beta 1AR, around 20% through beta 2AR. Norepinephrine 85-102 adrenoceptor beta 2 Homo sapiens 172-180 1652275-1 1991 Heart rate and force can be increased by noradrenaline and adrenaline through an interaction with both beta 1-adrenoceptors (beta 1AR) and beta 2-adrenoceptors (beta 2 AR). Norepinephrine 41-54 adrenoceptor beta 2 Homo sapiens 161-170 1652035-1 1991 Low doses (10(-16)-10(-10) M) of endothelin-3 (ET-3) elicited continuous vasodilations of mesenteric arteries preconstricted with norepinephrine (NE) but not with KCl. Norepinephrine 130-144 endothelin 3 Homo sapiens 33-45 1652035-1 1991 Low doses (10(-16)-10(-10) M) of endothelin-3 (ET-3) elicited continuous vasodilations of mesenteric arteries preconstricted with norepinephrine (NE) but not with KCl. Norepinephrine 130-144 endothelin 3 Homo sapiens 47-51 1717871-1 1991 The purpose of this study was to determine whether norepinephrine (NE) mediated the reduction in the activity of tryptophan hydroxylase (TPH) in the hippocampus and other serotonergic changes, induced by a single or multiple administrations of methamphetamine. Norepinephrine 51-65 tryptophan hydroxylase 1 Rattus norvegicus 113-135 22200605-0 2012 Embryonic lethality in mice lacking mismatch-specific thymine DNA glycosylase is partially prevented by DOPS, a precursor of noradrenaline. Norepinephrine 125-138 thymine DNA glycosylase Mus musculus 54-77 22200605-5 2012 On the other hand, the levels of noradrenaline in 10.5 dpc whole embryos, which is necessary for normal embryogenesis, were dramatically reduced in Tdg (-/-) embryos. Norepinephrine 33-46 thymine DNA glycosylase Mus musculus 148-151 22200605-11 2012 These results suggest that embryonic lethality in Tdg (-/-) embryos is due, in part, to the reduction of noradrenaline levels. Norepinephrine 105-118 thymine DNA glycosylase Mus musculus 50-53 22184028-1 2011 To interfere with the drug-cue memory processes of addicts such as reconsolidation by the administration of the beta-adrenergic receptor (beta-AR) of norepinephrine (NE) antagonist propranolol (PRO) has become a potential therapy in the future to decrease or inhibit relapse. Norepinephrine 150-164 adrenergic receptor, beta 1 Mus musculus 112-136 22184028-1 2011 To interfere with the drug-cue memory processes of addicts such as reconsolidation by the administration of the beta-adrenergic receptor (beta-AR) of norepinephrine (NE) antagonist propranolol (PRO) has become a potential therapy in the future to decrease or inhibit relapse. Norepinephrine 150-164 adrenergic receptor, beta 1 Mus musculus 138-145 21947296-4 2011 Using myography, arteries from NBCn1 knockout mice showed reduced acetylcholine-induced NO-mediated relaxations and lower rho-kinase-dependent norepinephrine-stimulated smooth muscle Ca2+ sensitivity. Norepinephrine 143-157 solute carrier family 4, sodium bicarbonate cotransporter, member 7 Mus musculus 31-36 21536121-4 2011 In the present study, we examined the effects of noradrenaline and adrenaline, stress-related catecholamines, on IL-33 production by dendritic cells (DCs). Norepinephrine 49-62 interleukin 33 Mus musculus 113-118 21536121-7 2011 Noradrenaline or adrenaline dramatically enhanced IL-33 mRNA expression and its protein synthesis by DCs upon LPS stimulation. Norepinephrine 0-13 interleukin 33 Mus musculus 50-55 21536121-8 2011 The noradrenaline-induced enhancement of IL-33 production was completely blocked by beta(2)-adrenoceptor specific antagonist ICI 118,551, while beta(2)-adrenoceptor specific agonist salmeterol enhanced DC production of IL-33. Norepinephrine 4-17 interleukin 33 Mus musculus 41-46 21536121-8 2011 The noradrenaline-induced enhancement of IL-33 production was completely blocked by beta(2)-adrenoceptor specific antagonist ICI 118,551, while beta(2)-adrenoceptor specific agonist salmeterol enhanced DC production of IL-33. Norepinephrine 4-17 interleukin 33 Mus musculus 219-224 21536121-9 2011 Protein kinase A (PKA) specific inhibitor H89 blocked the noradrenaline-induced IL-33 production. Norepinephrine 58-71 interleukin 33 Mus musculus 80-85 21683614-10 2011 In addition, intradermal injection of norepinephrine along with Pam3CysSK4+muramyl dipeptide increased the Th17 response to an immunogenic protein and this effect was reversed by a beta2-adrenoceptor antagonist. Norepinephrine 38-52 hemoglobin, beta adult minor chain Mus musculus 181-186 1717871-1 1991 The purpose of this study was to determine whether norepinephrine (NE) mediated the reduction in the activity of tryptophan hydroxylase (TPH) in the hippocampus and other serotonergic changes, induced by a single or multiple administrations of methamphetamine. Norepinephrine 51-65 tryptophan hydroxylase 1 Rattus norvegicus 137-140 1829900-1 1991 Previous studies from our laboratories have demonstrated a selective increase in stores of atrial natriuretic peptide (ANP) in the anterior hypothalamus of NaCl-sensitive spontaneously hypertensive rats (SHR-S) compared to NaCl-resistant Wistar-Kyoto (WKY) controls and have suggested that anterior hypothalamic ANP contributes to the pathogenesis of NaCl-sensitive hypertension in SHR-S by local inhibition of norepinephrine release. Norepinephrine 411-425 natriuretic peptide A Rattus norvegicus 91-117 2033506-1 1991 Previous studies have reported that maximally effective concentrations of the "mixed" alpha and beta adrenoceptor agonists, epinephrine and norepinephrine, cause greater amounts of mucin secretion than the "pure" beta adrenoceptor agonist, isoproterenol, and that this response requires extracellular calcium. Norepinephrine 140-154 solute carrier family 13 member 2 Rattus norvegicus 181-186 21740976-7 2011 Additionally, saliva samples were taken throughout the experimental session to examine salivary alpha-amylase, a biomarker for norepinephrine. Norepinephrine 127-141 amylase alpha 1A Homo sapiens 87-109 21936631-6 2011 CONCLUSIONS: Norepinephrine increases ubiquitination of Cx43 in cardiomyocytes, possibly via Nedd4. Norepinephrine 13-27 NEDD4 E3 ubiquitin protein ligase Rattus norvegicus 93-98 20832122-1 2011 There is growing evidence that blood levels of brain-derived neurotrophic factor (BDNF) and 3-methoxy-4-hydroxyphenylglycol (MHPG), a major metabolite of noradrenaline, are related to depression-associated personality traits as well as to depressive, suicidal and anxious states. Norepinephrine 154-167 brain derived neurotrophic factor Homo sapiens 47-80 20832122-1 2011 There is growing evidence that blood levels of brain-derived neurotrophic factor (BDNF) and 3-methoxy-4-hydroxyphenylglycol (MHPG), a major metabolite of noradrenaline, are related to depression-associated personality traits as well as to depressive, suicidal and anxious states. Norepinephrine 154-167 brain derived neurotrophic factor Homo sapiens 82-86 20933023-0 2011 Central injections of noradrenaline induce reinstatement of cocaine seeking and increase c-fos mRNA expression in the extended amygdala. Norepinephrine 22-35 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 89-94 1882084-3 1991 The findings revealed that oxytocin caused the release of more norepinephrine (NE) from the denervated glands up to 24 h after treatment. Norepinephrine 63-77 oxytocin/neurophysin I prepropeptide Homo sapiens 27-35 21560326-3 2011 The effects of accumulated apelin on pulmonary arterial rings preconstricted with norepinephrine (NE) were observed by using tissue organ bath system. Norepinephrine 82-96 apelin Rattus norvegicus 27-33 21233615-5 2011 RESULTS: The reactivity of SMAs and VSMCs to norepinephrine after shock or hypoxia was positively correlated with changes in the RhoA and Rac1 activity ratio. Norepinephrine 45-59 ras homolog family member A Rattus norvegicus 129-133 1826282-9 1991 In vitro, [3H]thymidine incorporation into hepatocyte DNA in the presence of hepatocyte growth factor is greater if 10(-5) mol/L norepinephrine is also present in the media. Norepinephrine 129-143 hepatocyte growth factor Rattus norvegicus 77-101 20875861-2 2011 Recently, we showed that AP-2beta, a member of the AP2 family, plays a critical role in the development of sympathetic neurons and locus coeruleus and their norepinephrine (NE) neurotransmitter phenotype. Norepinephrine 157-171 transcription factor AP-2 beta Mus musculus 25-33 1825843-8 1991 We compared the sensitivities of Ca2(+)- and phorbol ester-induced release of noradrenaline to the protein kinase inhibitors H-7 and polymyxin B and to antibodies raised against synaptic protein kinase C substrate B-50. Norepinephrine 78-91 solute carrier family 9 member A2 Rattus norvegicus 125-144 20954794-1 2010 The alpha(1)-adrenergic receptor (AR) subtypes (alpha(1a), alpha(1b), and alpha(1d)) mediate several physiological effects of epinephrine and norepinephrine. Norepinephrine 142-156 calcium channel, voltage-dependent, N type, alpha 1B subunit Mus musculus 59-67 20813157-5 2010 Pretreatment with the selective alpha(1B)-adrenergic receptor antagonist chloroethylclonidine eliminated the inhibitory effect of noradrenaline. Norepinephrine 130-143 adrenoceptor alpha 1B Homo sapiens 32-61 20813157-8 2010 These results suggest that noradrenaline suppresses Cs-sensitive and TEA-insensitive potassium channels via the alpha(1B)-adrenergic receptor in human osteoblasts. Norepinephrine 27-40 adrenoceptor alpha 1B Homo sapiens 112-141 20680617-1 2010 In this study, the first micro-total analysis system (mu-TAS) for catecholamines (dopamine, epinephrine, and norepinephrine) analysis in which preconcentration, separation, and determination steps were integrated on a microchip was developed. Norepinephrine 109-123 THAS Homo sapiens 57-60 21046458-4 2010 Under basal conditions, VMAT1 is widely expressed in all adrenal chromaffin cells, while VMAT2 is co-localized with tyrosine hydroxylase (TH) but not phenylethanolamine N-methyltransferase (PNMT), indicating its expression in norepinephrine (NE)-, but not epinephrine (Epi)-synthesizing chromaffin cells. Norepinephrine 226-240 solute carrier family 18 member A2 Rattus norvegicus 89-94 19725917-6 2010 Pre-incubation of mesenteric arterioles with anti-TRPC1 and anti-TRPC3 antibodies significantly reduced norepinephrine-induced vasomotion and calcium influx. Norepinephrine 104-118 transient receptor potential cation channel, subfamily C, member 1 Rattus norvegicus 50-55 1900942-0 1991 Norepinephrine and isoproterenol increase the phosphorylation of synapsin I and synapsin II in dentate slices of young but not aged Fisher 344 rats. Norepinephrine 0-14 synapsin I Rattus norvegicus 65-75 1705122-0 1991 Endothelin-1 stimulation of noradrenaline and adrenaline release from adrenal chromaffin cells. Norepinephrine 28-41 endothelin 1 Bos taurus 0-12 1705122-1 1991 Endothelin-1 (ET-1) stimulated release of both noradrenaline and adrenaline from cultured bovine adrenal chromaffin cells; stimulated release was small compared to that elicited by 50 mM potassium. Norepinephrine 47-60 endothelin 1 Bos taurus 0-12 1705122-1 1991 Endothelin-1 (ET-1) stimulated release of both noradrenaline and adrenaline from cultured bovine adrenal chromaffin cells; stimulated release was small compared to that elicited by 50 mM potassium. Norepinephrine 47-60 endothelin 1 Bos taurus 14-18 1705122-7 1991 These results show that ET-1 may stimulate both noradrenaline and adrenaline containing chromaffin cells by a mechanism which, while partially dependent on dihydropyridine sensitive calcium channels, is distinct from the calcium channel agonist or membrane depolarization. Norepinephrine 48-61 endothelin 1 Bos taurus 24-28 20739005-1 2010 LeuT is a member of the neurotransmitter/sodium symporter family, which includes the neuronal transporters for serotonin, norepinephrine, and dopamine. Norepinephrine 122-136 Leucine transport, high Homo sapiens 0-4 1671029-9 1991 In addition, dopamine DA1 agonism caused further increases in norepinephrine concentration and plasma renin activity. Norepinephrine 62-76 immunoglobulin heavy diversity 4-11 (non-functional) Homo sapiens 22-25 2085713-9 1990 The effect of a low dose of PAF (0.1 microgram kg-1) on the vascular permeability of the trachea and bronchi (but not of the parenchyma) was potentiated by compound U-44069 (5.0 micrograms kg-1) or noradrenaline (400 ng kg-1) whereas the effect of a high dose of PAF (5.0 micrograms kg-1) was not affected. Norepinephrine 198-211 PCNA clamp associated factor Rattus norvegicus 28-31 20118201-5 2010 The elevation of the plasma norepinephrine level caused by the subtotal nephrectomy + salt loading was also reduced in the V1aR KO mice. Norepinephrine 28-42 arginine vasopressin receptor 1A Mus musculus 123-127 19538471-1 2010 By employing a pharmacological approach, we have shown that phospholipase C (PLC) activity is involved in the regulation of gene expression of transcription factors such as c-Fos and c-Jun in cardiomyocytes in response to norepinephrine (NE). Norepinephrine 222-236 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 175-178 19538471-1 2010 By employing a pharmacological approach, we have shown that phospholipase C (PLC) activity is involved in the regulation of gene expression of transcription factors such as c-Fos and c-Jun in cardiomyocytes in response to norepinephrine (NE). Norepinephrine 222-236 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 183-188 20036647-5 2010 Intra-arterial administration of cholecystokinin-8 (CCK) at the dose of 50 mg/kg was used to induce oxytocin and noradrenaline release. Norepinephrine 113-126 cholecystokinin Rattus norvegicus 33-50 20036647-5 2010 Intra-arterial administration of cholecystokinin-8 (CCK) at the dose of 50 mg/kg was used to induce oxytocin and noradrenaline release. Norepinephrine 113-126 cholecystokinin Rattus norvegicus 52-55 20036647-8 2010 Central administration of leptin significantly reduced both plasma oxytocin and hypothalamic noradrenaline responses to CCK at 20 min following the treatments. Norepinephrine 93-106 cholecystokinin Rattus norvegicus 120-123 20595783-0 2010 Noradrenaline induces clock gene Per1 mRNA expression in C6 glioma cells through beta(2)-adrenergic receptor coupled with protein kinase A - cAMP response element binding protein (PKA-CREB) and Src-tyrosine kinase - glycogen synthase kinase-3beta (Src-GSK-3beta). Norepinephrine 0-13 cAMP responsive element binding protein 1 Homo sapiens 141-178 20595783-0 2010 Noradrenaline induces clock gene Per1 mRNA expression in C6 glioma cells through beta(2)-adrenergic receptor coupled with protein kinase A - cAMP response element binding protein (PKA-CREB) and Src-tyrosine kinase - glycogen synthase kinase-3beta (Src-GSK-3beta). Norepinephrine 0-13 cAMP responsive element binding protein 1 Homo sapiens 184-188 19968887-4 2009 RESULTS: The activation of naive CD8+ T lymphocytes by CD3/CD28 cross-linking was inhibited by norepinephrine and dopamine, which was caused by a downregulation of interleukin (IL)-2 expression via Erk1/2 and NF-kappaB inhibition. Norepinephrine 95-109 CD8a molecule Homo sapiens 33-36 19643091-8 2009 MSG- and vehicle-treated hamsters given an exogenous norepinephrine challenge showed identical increases in the duration and peak of T(IBAT). Norepinephrine 53-67 solute carrier family 10 member 2 Homo sapiens 135-139 1962795-8 1990 Norepinephrine-precontracted aorta strips from rats receiving a non-pressor dose of angiotensin II were more sensitive to the relaxant effect of ANF. Norepinephrine 0-14 natriuretic peptide A Rattus norvegicus 145-148 2146891-3 1990 The release of ANP was markedly blunted to acute volume expansion (+67% vs. +357% in controls, P less than 0.01) but was only moderately reduced after norepinephrine infusion (+106% vs. +212%, P less than 0.05) and was normal after acute salt load [+148% vs. +180% in controls, not significant (NS)]. Norepinephrine 151-165 natriuretic peptide A Rattus norvegicus 15-18 2253318-2 1990 PAF infusion (50 ng/kg/min for 60 min) resulted in a sustained hypotension, with tachycardia and elevated plasma norepinephrine (NE; 1.8-fold increase), epinephrine (E; 6.7-fold increase), and dopamine (DA; 1.0-fold increase) at 30 min after beginning infusion. Norepinephrine 113-127 PCNA clamp associated factor Rattus norvegicus 0-3 19596829-12 2009 These results suggest that PP36 can preserve heart function during the recovery from acute ischemic injury, and may modulate the cardiac norepinephrine release and eNOS protein level. Norepinephrine 137-151 linker for activation of T cells Rattus norvegicus 27-31 19690620-1 2009 BACKGROUND: Candidate genes of psychological importance include 5HT2A, 5HT2C, and COMT, implicated in the serotonin, noradrenaline and dopamine pathways, which also may be involved in regulation of energy balance. Norepinephrine 117-130 5-hydroxytryptamine receptor 2C Homo sapiens 71-76 19632578-7 2009 Release patterns included epinephrine and dopamine peaks at the time of BD and a norepinephrine peak 1 hour later. Norepinephrine 81-95 pseudopodium enriched atypical kinase 1 Homo sapiens 96-102 19420300-7 2009 However, beta(2)-adrenoceptor-mediated Ca(2+) release was independent of measurable increases in phospholipase C activity and resistant to inhibitors of protein kinases A and C. Interestingly, single-cell imaging demonstrated that particularly lower concentrations of muscarinic receptor agonists facilitated marked oscillatory Ca(2+) signaling to noradrenaline. Norepinephrine 348-361 adrenoceptor beta 2 Homo sapiens 9-29 19576631-0 2009 Brain derived neurotrophic factor and neurotrophin-4 employ different intracellular pathways to modulate norepinephrine uptake and release in rat hypothalamus. Norepinephrine 105-119 brain-derived neurotrophic factor Rattus norvegicus 0-33 19576631-0 2009 Brain derived neurotrophic factor and neurotrophin-4 employ different intracellular pathways to modulate norepinephrine uptake and release in rat hypothalamus. Norepinephrine 105-119 neurotrophin 4 Rattus norvegicus 38-52 19576631-4 2009 Thus, we have studied the effects of the neurotrophin family members nerve growth factor (NGF), brain derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4) on norepinephrine (NE) neuronal uptake and its evoked release, as well as the receptor and the intracellular pathways involved in these processes in rat hypothalamus. Norepinephrine 166-180 neurotrophin 4 Rattus norvegicus 141-155 19576631-4 2009 Thus, we have studied the effects of the neurotrophin family members nerve growth factor (NGF), brain derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4) on norepinephrine (NE) neuronal uptake and its evoked release, as well as the receptor and the intracellular pathways involved in these processes in rat hypothalamus. Norepinephrine 166-180 neurotrophin 4 Rattus norvegicus 157-161 19285120-4 2009 Dopamine-beta-hydroxylase (DbetaH), the enzyme synthesizing noradrenaline was examined in the locus coeruleus (LC) in these same cats. Norepinephrine 60-73 dopamine beta-hydroxylase Felis catus 0-25 19285120-4 2009 Dopamine-beta-hydroxylase (DbetaH), the enzyme synthesizing noradrenaline was examined in the locus coeruleus (LC) in these same cats. Norepinephrine 60-73 dopamine beta-hydroxylase Felis catus 27-33 19489787-6 2009 Further results of Western blotting found that the protein expression of tyrosine hydroxylase and synapsin I (especially its active form, synapsin I phosphoSer603) was also down-regulated, which were directly related to synthesis and release of norepinephrine, respectively. Norepinephrine 245-259 synapsin I Rattus norvegicus 98-108 19489787-6 2009 Further results of Western blotting found that the protein expression of tyrosine hydroxylase and synapsin I (especially its active form, synapsin I phosphoSer603) was also down-regulated, which were directly related to synthesis and release of norepinephrine, respectively. Norepinephrine 245-259 synapsin I Rattus norvegicus 138-148 19489787-7 2009 All the results suggest that Y-27632 is able to down-regulate norepinephrine synthesis and release, the direct mechanism of which may be associated with down-regulation on expression of some proteins, including tyrosine hydroxylase and synapsin I. Norepinephrine 62-76 synapsin I Rattus norvegicus 236-246 1981788-5 1990 Compared to naive PC12 cells, K-ras infected PC12 cells had (a) higher activities of acetylcholinesterase and choline acetyltransferase, two enzymes involved in acetylcholine metabolism; (b) enhanced activity of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis; (c) a higher, evoked norepinephrine release; and (d) similar levels of sodium-dependent uptake of both choline and norepinephrine. Norepinephrine 311-325 KRAS proto-oncogene, GTPase Rattus norvegicus 30-35 1981788-5 1990 Compared to naive PC12 cells, K-ras infected PC12 cells had (a) higher activities of acetylcholinesterase and choline acetyltransferase, two enzymes involved in acetylcholine metabolism; (b) enhanced activity of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis; (c) a higher, evoked norepinephrine release; and (d) similar levels of sodium-dependent uptake of both choline and norepinephrine. Norepinephrine 405-419 KRAS proto-oncogene, GTPase Rattus norvegicus 30-35 1983139-8 1990 A significant relationship between the concentrations of somatostatin and noradrenaline in cord blood was found, (r = 0.7, n = 11, P less than 0.01). Norepinephrine 74-87 somatostatin Homo sapiens 57-69 19190077-9 2009 Most abdominal and thoracic SDHB-PGLs hypersecrete either norepinephrine or norepinephrine and dopamine. Norepinephrine 58-72 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 28-32 19190077-9 2009 Most abdominal and thoracic SDHB-PGLs hypersecrete either norepinephrine or norepinephrine and dopamine. Norepinephrine 76-90 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 28-32 19212675-2 2009 By microarray expression analysis (Affymetrix HU133A) important players in the noradrenalin biosynthesis pathway (DBH, DDC, GATA2, GATA3, PHOX2A, PHOX2B, SLC6A2 SLC18A1 and TH) were found to be among the top ranked genes in showing lower expression in unfavorable NB tumor types as compared to favorable ones. Norepinephrine 79-91 GATA binding protein 3 Homo sapiens 131-136 1983139-15 1990 We conclude that the somatostatin level, but not the gastrin level is influenced by the degree of fetal stress during labour, as evidenced by the relationship with noradrenaline. Norepinephrine 164-177 somatostatin Homo sapiens 21-33 1698509-1 1990 The neuropeptide galanin (GAL) has been found to elicit feeding after injection into the paraventricular hypothalamic nucleus (PVN), where it coexists with norepinephrine (NE), a neurotransmitter believed to be important in the control of natural feeding behavior. Norepinephrine 156-170 galanin and GMAP prepropeptide Homo sapiens 17-24 1698509-1 1990 The neuropeptide galanin (GAL) has been found to elicit feeding after injection into the paraventricular hypothalamic nucleus (PVN), where it coexists with norepinephrine (NE), a neurotransmitter believed to be important in the control of natural feeding behavior. Norepinephrine 156-170 galanin and GMAP prepropeptide Homo sapiens 26-29 2164246-0 1990 Effect of high dose norepinephrine versus epinephrine on cerebral and myocardial blood flow during CPR. Norepinephrine 20-34 cytochrome p450 oxidoreductase Sus scrofa 99-102 2164246-2 1990 The administration of norepinephrine (NE) in doses of 0.12 and 0.16 mg/kg demonstrated a trend toward improved CBF and MBF during CPR over that seen with E 0.20 mg/kg in the same animal model. Norepinephrine 22-36 cytochrome p450 oxidoreductase Sus scrofa 130-133 2252308-17 1990 In the rat saphenous vein, 5-HT1B receptors mediate inhibition of noradrenaline release. Norepinephrine 66-79 5-hydroxytryptamine receptor 1B Rattus norvegicus 27-33 2369799-0 1990 Effects of a protein kinase C inhibitor (H-7) on norepinephrine release from vascular adrenergic neurons in spontaneously hypertensive rats. Norepinephrine 49-63 solute carrier family 9 member A2 Rattus norvegicus 41-44 19073902-3 2009 We hypothesized that in this setting, renin secretion and renin-dependent sodium excretion are controlled by via the renal nerves and therefore are eliminated or reduced by blocking the action of norepinephrine on the juxtaglomerular cells with the beta1-receptor antagonist metoprolol. Norepinephrine 196-210 renin Canis lupus familiaris 38-43 19073902-3 2009 We hypothesized that in this setting, renin secretion and renin-dependent sodium excretion are controlled by via the renal nerves and therefore are eliminated or reduced by blocking the action of norepinephrine on the juxtaglomerular cells with the beta1-receptor antagonist metoprolol. Norepinephrine 196-210 renin Canis lupus familiaris 58-63 19073902-12 2009 In conclusion, PRC depended on dietary sodium and beta1-adrenergic control as expected; however, the acute sodium-driven decrease in PRC at constant MAP and GFR was unaffected by beta1-receptor blockade demonstrating that renin may be regulated without changes in MAP, GFR, or beta1-mediated effects of norepinephrine. Norepinephrine 303-317 renin Canis lupus familiaris 222-227 18854975-7 2009 Due to the noradrenaline infusion heart rate, end-systolic pressure as well as dp/dt (max) and dp/dt (max) were significantly higher and relaxation time significantly lower in the CLP-mice, again without difference between the genetic strains. Norepinephrine 11-24 hyaluronan and proteoglycan link protein 1 Mus musculus 180-183 19077688-7 2009 Similarly, renal vascular reactivity to angiotensin II, endothelin-1 and norepinephrine is attenuated by approximately 50% in mice lacking CD38, the main mammalian ADPR cyclase. Norepinephrine 73-87 CD38 antigen Mus musculus 139-143 2177712-0 1990 Role of adenylate cyclase in modulatory effect of neuropeptide Y on [3H]noradrenaline release in guinea-pig vas deferens. Norepinephrine 72-85 pro-neuropeptide Y Cavia porcellus 50-64 19092146-7 2009 As compared with control subjects, MC4R-deficient subjects had a lower increase in heart rate on waking (P=0.007), a lower heart rate during euglycemic hyperinsulinemia (P<0.001), and lower 24-hour urinary norepinephrine excretion (P=0.04). Norepinephrine 209-223 melanocortin 4 receptor Homo sapiens 35-39 19120138-3 2008 Forced swimming, systemic interleukin-1beta (IL-1beta), and cholecystokinin (CCK) all activate brain stem noradrenergic cell groups, stimulate noradrenaline release in the PVN, and activate the HPA axis in nonpregnant rats. Norepinephrine 143-156 cholecystokinin Rattus norvegicus 60-75 19120138-3 2008 Forced swimming, systemic interleukin-1beta (IL-1beta), and cholecystokinin (CCK) all activate brain stem noradrenergic cell groups, stimulate noradrenaline release in the PVN, and activate the HPA axis in nonpregnant rats. Norepinephrine 143-156 cholecystokinin Rattus norvegicus 77-80 19020050-5 2008 Conversely, the transfection of synthetic anti-miR oligonucleotides that inhibit miR-338 increases COXIV levels, and results in a significant increase in oxidative phosphorylation and also norepinephrine uptake in the axons. Norepinephrine 189-203 membrane associated ring-CH-type finger 8 Homo sapiens 47-50 1701203-5 1990 ET-1 also enhanced both components of the response to high frequency field stimulation (2 to 16 Hz) and contractions induced by submaximal concentrations of noradrenaline, ATP or KCl. Norepinephrine 157-170 DNA segment, Chr 9, MRC UK Mouse Genome Centre 40 expressed Mus musculus 0-4 2139164-1 1990 Recently, it has been reported that atrial natriuretic peptide (ANP) reverses or prevents acute renal failure induced by norepinephrine in rats. Norepinephrine 121-135 natriuretic peptide A Rattus norvegicus 36-62 1981283-14 1990 In addition, the time course of the norepinephrine-mediated slow EPSPs and IPSPs in SPN is consistent with a gain-setting function. Norepinephrine 36-50 DEAF1 transcription factor Homo sapiens 84-87 25887954-2 2015 We have recently demonstrated that beta1-adrenoceptor (AR) activation by endogenous norepinephrine contributes to cardiomyocyte apoptosis in endotoxemic mice. Norepinephrine 84-98 adrenergic receptor, beta 1 Mus musculus 35-53 25887954-2 2015 We have recently demonstrated that beta1-adrenoceptor (AR) activation by endogenous norepinephrine contributes to cardiomyocyte apoptosis in endotoxemic mice. Norepinephrine 84-98 adrenergic receptor, beta 1 Mus musculus 55-57 34957858-12 2022 These responses may be mediated by hypoxemia induced endocrine responses including increased norepinephrine and cortisol, which inhibit pancreatic insulin secretion resulting in lower insulin concentrations and decreased stimulation of glucose utilization. Norepinephrine 93-107 LOC105613195 Ovis aries 184-191 34767786-8 2021 SIGNIFICANCE The beta2-adrenergic receptor (beta2 AR), which belongs to the vast family of Guanine nucleotide-binding protein coupled receptors (GPCRs), is a transmembrane protein that is activated by the catecholamines norepinephrine (noradrenaline) and epinephrine (adrenaline). Norepinephrine 220-234 adrenoceptor beta 2 Homo sapiens 17-42 34767786-8 2021 SIGNIFICANCE The beta2-adrenergic receptor (beta2 AR), which belongs to the vast family of Guanine nucleotide-binding protein coupled receptors (GPCRs), is a transmembrane protein that is activated by the catecholamines norepinephrine (noradrenaline) and epinephrine (adrenaline). Norepinephrine 236-249 adrenoceptor beta 2 Homo sapiens 17-42 34880955-11 2021 These results suggest that elevation of solitary nitric oxide signaling derived from nNOS mediates stress-precipitated anxiety and norepinephrine release in the BNST during protracted EtOHW. Norepinephrine 131-145 nitric oxide synthase 1 Rattus norvegicus 85-89 18980978-11 2008 In vitro analyses showed that macrophage MMP-9 production could be directly enhanced (up to a 2-fold increase) by the stress hormones norepinephrine and cortisol. Norepinephrine 134-148 matrix metallopeptidase 9 Homo sapiens 41-46 34417358-9 2021 These data support our hypothesis that norepinephrine serves as a novelty signal to update HPC contextual representations via BAR activation-facilitated recruitment of new neurons. Norepinephrine 39-53 adrenoceptor beta 2 Homo sapiens 126-129 34358571-10 2021 These findings demonstrate statistically significant relationships among vocal impairment, anxiety, and brainstem norepinephrine in the Pink1-/- rat model of PD. Norepinephrine 114-128 PTEN induced kinase 1 Rattus norvegicus 136-141 34355529-8 2021 Adrenaline, noradrenaline, and phenylephrine were highly efficacious alpha1-agonists at all three receptor subtypes. Norepinephrine 12-25 immunoglobulin kappa variable 2D-30 Homo sapiens 69-75 18845978-1 2008 PURPOSE: To examine the influence of a selective noradrenaline reuptake inhibitor (SNRI) on the exercise-induced increase in circulating brain-derived neurotrophic factor (BDNF). Norepinephrine 49-62 brain derived neurotrophic factor Homo sapiens 137-170 18845978-1 2008 PURPOSE: To examine the influence of a selective noradrenaline reuptake inhibitor (SNRI) on the exercise-induced increase in circulating brain-derived neurotrophic factor (BDNF). Norepinephrine 49-62 brain derived neurotrophic factor Homo sapiens 172-176 18762182-5 2008 Opposite effects were also observed in the expression of the transcription factor CREB with norepinephrine upregulating phosphorylated CREB (pCREB) levels, while dexamethasone downregulated CREB mRNA and protein levels, as well as pCREB levels. Norepinephrine 92-106 cAMP responsive element binding protein 1 Homo sapiens 82-86 18762182-5 2008 Opposite effects were also observed in the expression of the transcription factor CREB with norepinephrine upregulating phosphorylated CREB (pCREB) levels, while dexamethasone downregulated CREB mRNA and protein levels, as well as pCREB levels. Norepinephrine 92-106 cAMP responsive element binding protein 1 Homo sapiens 135-139 18762182-5 2008 Opposite effects were also observed in the expression of the transcription factor CREB with norepinephrine upregulating phosphorylated CREB (pCREB) levels, while dexamethasone downregulated CREB mRNA and protein levels, as well as pCREB levels. Norepinephrine 92-106 cAMP responsive element binding protein 1 Homo sapiens 135-139 18594791-10 2008 Urinary epinephrine and norepinephrine excretion in Il1ra (-/-) mice was significantly increased compared with WT mice, suggesting that Il1ra (-/-) mice have increased sympathetic tone. Norepinephrine 24-38 interleukin 1 receptor antagonist Mus musculus 52-57 18668589-10 2008 Culture of CD4+CD25+ cells with norepinephrine (10(-5)M) for 24 hours before transfer worsened the arthritis. Norepinephrine 32-46 CD4 antigen Mus musculus 11-14 34275002-9 2021 The expression of Bmal1, Per1 and Per3 in control subjects was also influenced by incubation with 1 microM norepinephrine. Norepinephrine 107-121 aryl hydrocarbon receptor nuclear translocator like Homo sapiens 18-23 34083626-3 2021 We found that senior investors display higher gray matter volume and increased structural brain connectivity in dopamine-related pathways, as well as a set of genes functionally associated with adrenaline and noradrenaline biosynthesis (SLC6A3, TH and SLC18A2), which is seemingly involved in reward processing and bodily stress responses during financial trading. Norepinephrine 209-222 solute carrier family 6 member 3 Homo sapiens 237-243 34309518-8 2021 ADRA2 activation via brimonidine-induced vasoconstriction was greater in skin arterioles than in small skin arteries, and more potent than that with norepinephrine (NE). Norepinephrine 149-163 adrenoceptor alpha 2A Homo sapiens 0-5 34812056-8 2021 The in vitro experiments revealed that treatments with norepinephrine markedly increased mRNAs and proteins of ATF2 and CBP/p300 and reduced mRNA and proteins of HDAC2 and HDAC5 in MN9D cells. Norepinephrine 55-69 CREB binding protein Mus musculus 120-128 34812056-9 2021 A ChIP assay showed that norepinephrine significantly increased CBP/p300 binding or reduced HDAC2 and HDAC5 binding on the TH promoter. Norepinephrine 25-39 CREB binding protein Rattus norvegicus 64-68 35351968-8 2022 EBI2 activation in brown adipocytes significantly reduces norepinephrine-induced cAMP production, whereas pharmacological inhibition or genetic ablation of EBI2 results in an increased response. Norepinephrine 58-72 G protein-coupled receptor 183 Mus musculus 0-4 35351968-8 2022 EBI2 activation in brown adipocytes significantly reduces norepinephrine-induced cAMP production, whereas pharmacological inhibition or genetic ablation of EBI2 results in an increased response. Norepinephrine 58-72 G protein-coupled receptor 183 Mus musculus 156-160 35351968-9 2022 Importantly, EBI2 significantly inhibits norepinephrine-induced activation of human brown adipocytes. Norepinephrine 41-55 G protein-coupled receptor 183 Homo sapiens 13-17 34772856-8 2022 Furthermore, urinary excretion of adrenaline and noradrenaline by fld mice was significantly higher compared with that of control mice. Norepinephrine 49-62 lipin 1 Mus musculus 66-69 35051185-5 2022 During spontaneous atrial contraction, PKD2L1del-Tg atria showed enhanced sensitivity to isoproterenol, norepinephrine, and epinephrine. Norepinephrine 104-118 polycystic kidney disease 2-like 1 Mus musculus 39-45 2676489-4 1989 Labeling of consecutive sections with phenylethanolamine-N-methyltransferase or AVT antibodies showed that both noradrenaline- and adrenaline-storing cells contain AVT-like immunoreactivity. Norepinephrine 112-125 phenylethanolamine N-methyltransferase Canis lupus familiaris 38-76 2615846-0 1989 Neuropeptide Y differentiates between exocytotic and nonexocytotic noradrenaline release in guinea-pig heart. Norepinephrine 67-80 pro-neuropeptide Y Cavia porcellus 0-14 18550369-1 2008 The design, synthesis, and SAR of a series of ring-constrained norepinephrine reuptake inhibitors are described. Norepinephrine 63-77 sarcosine dehydrogenase Homo sapiens 27-30 18598300-0 2008 Geniposide enhances melanogenesis by stem cell factor/c-Kit signalling in norepinephrine-exposed normal human epidermal melanocyte. Norepinephrine 74-88 KIT ligand Homo sapiens 37-53 18598300-2 2008 Stem cell factor from keratinocyte recognizes and activates its receptor c-kit carried by melanocyte to potent enhance melanocytic melanogenesis that can be suppressed by norepinephrine. Norepinephrine 171-185 KIT ligand Homo sapiens 0-16 18598300-8 2008 In addition, spectrophotometry demonstrated the enhancement effect of geniposide on melanogenesis (tyrosinase activity and melanin production) in norepinephrine-exposed normal human epidermal melanocyte at the presence of stem cell factor, which was blocked by c-kit inhibitory antibody K44.2. Norepinephrine 146-160 KIT ligand Homo sapiens 222-238 18598300-9 2008 Data from this study suggest that geniposide can enhance melanogenesis by stem cell factor/c-kit signalling in which the expression of c-kit receptor is augmented in norepinephrine-exposed normal human epidermal melanocyte. Norepinephrine 166-180 KIT ligand Homo sapiens 74-90 18387943-10 2008 Finally, we show that 1,2-dioleoyl-sn-glycerol mimics the effect of PMA to drive PKCdelta to caveolae and increase PKCdelta-Tyr(311) phosphorylation, whereas G protein-coupled receptor agonists such as norepinephrine and endothelin-1 do not. Norepinephrine 202-216 protein kinase C, delta Mus musculus 81-89 18387943-11 2008 These results suggest that norepinephrine and endothelin-1 increase 1,2-dioleoyl-sn-glycerol accumulation and activate PKCdelta exclusively in non-caveolae membranes. Norepinephrine 27-41 protein kinase C, delta Mus musculus 119-127 2615846-10 1989 The results indicate that NPY is co-released with noradrenaline only during calcium-dependent exocytosis. Norepinephrine 50-63 pro-neuropeptide Y Cavia porcellus 26-29 2571509-1 1989 The effect of prolonged treatment with antidepressant drugs on the phenylephrine- and norepinephrine (NE)-evoked reaction in hippocampal slices was examined by extracellular recording of the spontaneous activity of CA1 layer neurons. Norepinephrine 86-100 carbonic anhydrase 1 Homo sapiens 215-218 18403121-10 2008 Interestingly, 5-LOX deficiency and MK-886 treatment have been shown to be capable of increasing the behavioral effects of a noradrenaline/dopamine-potentiating drug, cocaine. Norepinephrine 125-138 arachidonate 5-lipoxygenase Mus musculus 15-20 18177483-13 2008 We conclude that noradrenaline-induced increases in the expression of NHE-3, NBC-1, BSC-1 and aquaporin-2 are likely to play an important role in the regulation of salt and water transport by noradrenaline in the kidney and may explain, at least in part, the altered renal sodium and water handling associated with overactivation of the sympathetic system. Norepinephrine 192-205 solute carrier family 12 member 1 Rattus norvegicus 84-89 18187403-3 2008 We have studied the sites of cPLA(2) phosphorylation and their significance in arachidonic acid (AA) release in response to norepinephrine (NE) in vivo in rabbit vascular smooth muscle cells (VSMCs) using specific anti-phospho-S515- and -S505 cPLA(2) antibodies and by mutagenesis of S515 and S505 to alanine. Norepinephrine 124-138 cytosolic phospholipase A2 Oryctolagus cuniculus 29-35 17853072-11 2008 These results suggest that systemic epinephrine, perhaps by evoking central norepinephrine release, modulates the increase in forebrain GABAA receptor binding induced by both insulin and stress. Norepinephrine 76-90 gamma-aminobutyric acid type A receptor gamma3 subunit Gallus gallus 136-150 18083901-4 2008 We identified the expression of the paxillin homologue hydrogen peroxide-inducible clone-5 (Hic-5) and showed its activation by norepinephrine (NE) in a Src-dependent manner. Norepinephrine 128-142 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 153-156 19020660-11 2008 CONCLUSIONS: Our results show that the binding of apoB100-LDL to adipocytes via the LDL receptor inhibits intracellular noradrenaline-induced lipolysis in adipocytes. Norepinephrine 120-133 low density lipoprotein receptor Mus musculus 84-96 17974982-7 2007 Regarding the effects of STAT3 activation, exposure to norepinephrine resulted in an increase in invasion and matrix metalloproteinase (MMP-2 and MMP-9) production. Norepinephrine 55-69 matrix metallopeptidase 2 Mus musculus 136-141 2569455-5 1989 Propranolol had no significant effect on the response to nerve stimulation, whereas ICI 118551, a selective beta 2-adrenoceptor antagonist, enhanced responses to nerve stimulation and injected norepinephrine. Norepinephrine 193-207 adrenoceptor beta 2 Homo sapiens 108-127 2670151-0 1989 Direct evidence that an increase in aortic norepinephrine level in response to insulin-induced hypoglycemia is due to increased adrenal norepinephrine output. Norepinephrine 43-57 insulin Canis lupus familiaris 79-86 2670151-0 1989 Direct evidence that an increase in aortic norepinephrine level in response to insulin-induced hypoglycemia is due to increased adrenal norepinephrine output. Norepinephrine 136-150 insulin Canis lupus familiaris 79-86 2670151-1 1989 This study reports on the major source of circulating norepinephrine that is known to increase, progressively, during sustained hypoglycemia induced by intravenous insulin administration. Norepinephrine 54-68 insulin Canis lupus familiaris 164-171 2648843-3 1989 Fetal plasma norepinephrine and epinephrine concentrations increased significantly during insulin infusion. Norepinephrine 13-27 LOC105613195 Ovis aries 90-97 17569658-5 2007 In contrast, we show that PKCdelta-Thr(505) phosphorylation dynamically increases in cardiomyocytes treated with phorbol 12-myristate 13-acetate or the alpha(1)-adrenergic receptor agonist norepinephrine via a mechanism that requires novel PKC isoform activity and not phosphoinositide-dependent kinase-1. Norepinephrine 189-203 protein kinase C, delta Mus musculus 26-34 17569658-5 2007 In contrast, we show that PKCdelta-Thr(505) phosphorylation dynamically increases in cardiomyocytes treated with phorbol 12-myristate 13-acetate or the alpha(1)-adrenergic receptor agonist norepinephrine via a mechanism that requires novel PKC isoform activity and not phosphoinositide-dependent kinase-1. Norepinephrine 189-203 protein kinase C, delta Mus musculus 26-29 17620967-5 2007 The Rho kinase inhibitor Y-27,632 caused a significantly greater inhibition of the contractile response to various agents (phenylephrine, norepinephrine, U46,619 and K) in MA of Ang II-14d compared to SHAM. Norepinephrine 138-152 angiogenin Rattus norvegicus 178-181 16944358-1 2007 Endothelin (ET)-1 is an endogenous vasoconstrictor which modulates norepinephrine (NE) release in myocardial ischemia reperfusion. Norepinephrine 67-81 endothelin-1 Cavia porcellus 0-17 17350522-5 2007 There is a close association between salivary alpha-amylase and plasma norepinephrine under stressful physical conditions. Norepinephrine 71-85 amylase alpha 1A Homo sapiens 37-59 17287506-2 2007 We report that genetic depletion of serotonin, dopamine, and norepinephrine in mice lacking the vesicular monoamine transporter (VMAT2 KO mice) causes an increase in cell death in the superficial layers of the cingulate and retrosplenial cortices during early postnatal life (postnatal days 0-4). Norepinephrine 61-75 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 129-134 17331215-3 2007 In anaesthetized subjects, the concentration of extracellular noradrenaline in NK1R-/- mice was two-fourfold greater than in NK1R+/+ mice. Norepinephrine 62-75 tachykinin receptor 1 Mus musculus 79-83 17331215-3 2007 In anaesthetized subjects, the concentration of extracellular noradrenaline in NK1R-/- mice was two-fourfold greater than in NK1R+/+ mice. Norepinephrine 62-75 tachykinin receptor 1 Mus musculus 125-129 17331215-10 2007 It is concluded that the greater basal efflux of noradrenaline in NK1R-/- mice is explained by increased transmitter release, coupled with desensitization of somatodendritic alpha2a-adrenoceptors. Norepinephrine 49-62 tachykinin receptor 1 Mus musculus 66-70 17224717-3 2007 The current study measured SERT occupancy and modulation of DAT by the serotonin/norepinephrine reuptake inhibitor (SNRI) venlafaxine using [123I]2beta-carbomethoxy-3beta-(4-iodophenyl)-tropane SPECT. Norepinephrine 81-95 solute carrier family 6 member 3 Homo sapiens 60-63 17113043-3 2007 In an effort to elucidate whether cannabinoid (CB1) receptors are positioned to presynaptically modulate norepinephrine release in the frontal cortex, immunocytochemical detection of the CB1 receptor and the catecholamine-synthesizing enzyme dopamine-beta-hydroxylase (DbetaH) was performed using confocal immunofluorescence microscopy and immunoelectron microscopy in rat brain. Norepinephrine 105-119 cannabinoid receptor 1 Rattus norvegicus 47-50 17113043-7 2007 In conclusion, the present neuroanatomical data suggest that cortical norepinephrine release may be modulated, in part, by CB1 receptors that are presynaptically distributed on noradrenergic axon terminals. Norepinephrine 70-84 cannabinoid receptor 1 Rattus norvegicus 123-126 17205149-5 2006 Factors such as leptin inducible factors (for example, noradrenaline), that regulate the activity of profibrogenic cytokines, such as IL-10 and TGF-beta, dictate the extent of fibrosis that occurs during liver injury. Norepinephrine 55-68 interleukin 10 Homo sapiens 134-139 17027833-3 2006 This study examines the associations of beta2-adrenoceptor polymorphism with relationships between plasma norepinephrine (NE) and leptin to evaluate further the mechanisms of obesity. Norepinephrine 106-120 adrenoceptor beta 2 Homo sapiens 40-58 2648843-7 1989 Increases in fetal heart rate during both the noninfused and insulin-infused states correlated significantly with increases in norepinephrine concentration. Norepinephrine 127-141 LOC105613195 Ovis aries 61-68 2467979-0 1989 Characterization of bradykinin-stimulated release of noradrenaline from cultured bovine adrenal chromaffin cells. Norepinephrine 53-66 kininogen 1 Bos taurus 20-30 2467979-2 1989 On exposure to bradykinin they released noradrenaline. Norepinephrine 40-53 kininogen 1 Bos taurus 15-25 2467979-4 1989 Bradykinin released noradrenaline with an EC50 of about 2 nM, with maximum release (2-3 times control incubations) less than that elicited by high potassium or nicotine. Norepinephrine 20-33 kininogen 1 Bos taurus 0-10 3978237-3 1985 The present study reports that bovine PTH-(1-34) can relax isolated rat tail artery helical strips precontracted by either arginine vasopressin, depolarizing concentrations of potassium chloride, or norepinephrine. Norepinephrine 199-213 parathyroid hormone Bos taurus 38-41 2990773-1 1985 The natriuretic substances were purified from rat atrium (ANF, atrial natriuretic factor) and were shown to be identical with the inhibitor of norepinephrine-induced contraction of smooth muscle. Norepinephrine 143-157 natriuretic peptide A Rattus norvegicus 58-61 2990773-1 1985 The natriuretic substances were purified from rat atrium (ANF, atrial natriuretic factor) and were shown to be identical with the inhibitor of norepinephrine-induced contraction of smooth muscle. Norepinephrine 143-157 natriuretic peptide A Rattus norvegicus 63-88 6097220-6 1984 Stimulation of mucin release by isoproterenol (10 microM), noradrenaline (10 microM) or adrenaline (10 microM) was inhibited by propranolol (30 microM) but not by phentolamine (30 microM). Norepinephrine 59-72 solute carrier family 13 member 2 Rattus norvegicus 15-20 16906479-5 2006 Primary adipocytes isolated from PPARgamma agonist-treated rats were also more responsive to noradrenaline stimulation expressed per cell, ruling out a contribution of an altered number of mature adipocytes in explants. Norepinephrine 93-106 peroxisome proliferator-activated receptor gamma Rattus norvegicus 33-42 16388933-7 2006 Interestingly, exposure to a lower concentration (1 microM) of the antidepressants tended to increase T-cell-derived IL-10 production, with significant effects elicited by the noradrenaline reuptake inhibitors reboxetine and desipramine. Norepinephrine 176-189 interleukin 10 Homo sapiens 117-122 6242556-4 1984 A significantly smaller augmentation of the natriuretic response to ANF was produced by equipressor does of norepinephrine and epinephrine, suggesting that the potentiation by ANG II and AVP were not entirely due to increased mean arterial pressure (MAP). Norepinephrine 108-122 natriuretic peptide A Rattus norvegicus 68-71 6091272-1 1984 Norepinephrine, briefly superfused during high-frequency stimulation of the mossy fibers in the rat hippocampal slice in vitro, produced a reversible increase in the magnitude, duration, and probability of induction of long-term synaptic potentiation in the CA3 subfield. Norepinephrine 0-14 carbonic anhydrase 3 Rattus norvegicus 258-261 6548381-0 1984 Neurochemical properties of AHR-9377: a novel inhibitor of norepinephrine reuptake. Norepinephrine 59-73 aryl hydrocarbon receptor Rattus norvegicus 28-31 6548381-1 1984 A novel potential antidepressant, AHR-9377, was evaluated for its inhibition of norepinephrine (NE), serotonin (5-HT) and dopamine (DA) reuptake in hypothalmic, cortical, and striatal rat synaptosomal preparations. Norepinephrine 80-94 aryl hydrocarbon receptor Rattus norvegicus 34-37 6492007-3 1984 The distribution of intracellular Ca2+ was determined, with electron probe X-ray microanalysis, in cryosections of preparations frozen in the relaxed state and at the peak of noradrenaline-induced contractions. Norepinephrine 175-188 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 34-37 16699769-1 2006 PURPOSE: The purpose of this study was to investigate the monoamine transporter status of dopamine, serotonin and norepinephrine throughout the brain in spinocerebellar ataxia type 2 (SCA2). Norepinephrine 114-128 ataxin 2 Homo sapiens 153-182 16699769-1 2006 PURPOSE: The purpose of this study was to investigate the monoamine transporter status of dopamine, serotonin and norepinephrine throughout the brain in spinocerebellar ataxia type 2 (SCA2). Norepinephrine 114-128 ataxin 2 Homo sapiens 184-188 16449297-4 2006 Baseline epinephrine and glucagon were similar, and norepinephrine was elevated, in CRH KO vs. WT mice. Norepinephrine 52-66 corticotropin releasing hormone Mus musculus 84-87 16449297-10 2006 However, Prior Hypo CRH KO mice had significantly lower day 2 epinephrine and norepinephrine vs. Norepinephrine 78-92 corticotropin releasing hormone Mus musculus 20-23 16531560-5 2006 Data will be discussed from studies involving the stimulation of the beta2 adrenergic receptor expressed on CD4+ T cells and B cells by norepinephrine or selective agonists. Norepinephrine 136-150 adrenoceptor beta 2 Homo sapiens 69-94 16677282-8 2006 RESULTS: Norepinephrine stimulated the expression of S100A8/S100A9 mRNAs via beta-adrenergic receptors in U-937 cells and significantly increased calprotectin production to about 3.6-fold that of the control. Norepinephrine 9-23 S100 calcium binding protein A9 Homo sapiens 60-66 16580633-6 2006 Interestingly, the direction of the emission ratio change of beta(2)AR was opposite to that of the norepinephrine-responsive alpha(2A) adrenergic receptor reported recently. Norepinephrine 99-113 adrenoceptor beta 2 Homo sapiens 61-70 16154248-3 2006 In addition, all three proteins are required for l-norepinephrine-facilitated iron uptake from transferrin as judged by failure of a fepA iroN cir triple mutant to grow in serum-containing medium in the presence of l-norepinephrine. Norepinephrine 49-65 transferrin Mus musculus 95-106 16154248-3 2006 In addition, all three proteins are required for l-norepinephrine-facilitated iron uptake from transferrin as judged by failure of a fepA iroN cir triple mutant to grow in serum-containing medium in the presence of l-norepinephrine. Norepinephrine 215-231 transferrin Mus musculus 95-106 16210849-1 2006 Beta-adrenergic receptor (betaAR) activation has been shown to maintain heart rate during hypoxia and to rescue the fetus from the fetal lethality that occurs in the absence of norepinephrine. Norepinephrine 177-191 adrenergic receptor, beta 1 Mus musculus 26-32 16183708-0 2006 Induction of beta3-adrenergic receptor functional expression following chronic stimulation with noradrenaline in neonatal rat cardiomyocytes. Norepinephrine 96-109 adrenoceptor beta 3 Rattus norvegicus 13-38 16213535-1 2006 Nicotinic acetylcholine receptor (nAChR)-evoked release of norepinephrine (NE) has been demonstrated in a number of brain regions that receive sole noradrenergic innervation from the locus coeruleus (LC). Norepinephrine 59-73 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 0-32 16213535-1 2006 Nicotinic acetylcholine receptor (nAChR)-evoked release of norepinephrine (NE) has been demonstrated in a number of brain regions that receive sole noradrenergic innervation from the locus coeruleus (LC). Norepinephrine 59-73 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 34-39 6492007-7 1984 The amplitude of reproducible interrupted contractions in Ca2+-free, high-K+ solution was graded with noradrenaline concentration. Norepinephrine 102-115 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 58-61 6492007-14 1984 is the store from which noradrenaline and caffeine release Ca2+. Norepinephrine 24-37 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 59-62 6522106-6 1984 ADP associated with thrombin failed to trigger formation of microthrombi but initiated platelet-rich thrombi in the pulmonary vasculature when associated with norepinephrine. Norepinephrine 159-173 prothrombin Oryctolagus cuniculus 20-28 16099895-1 2005 Existing evidence suggests that neuropeptide Y (NPY) acts as a neurotransmitter in vascular smooth muscle and is coreleased with norepinephrine from sympathetic nerves. Norepinephrine 129-143 neuropeptide Y Canis lupus familiaris 32-46 16099895-1 2005 Existing evidence suggests that neuropeptide Y (NPY) acts as a neurotransmitter in vascular smooth muscle and is coreleased with norepinephrine from sympathetic nerves. Norepinephrine 129-143 neuropeptide Y Canis lupus familiaris 48-51 6522106-8 1984 Furthermore, the ability of norepinephrine to elicit glomerular thrombosis in thrombin injected rabbits may provide an explanation for requirement of alpha-adrenergic stimulation in the endotoxin-induced generalized Shwartzman reaction. Norepinephrine 28-42 prothrombin Oryctolagus cuniculus 78-86 6088536-8 1984 Pulse-label and pulse-chase studies indicate that the conversion rate of phosphocholine to CDP-choline, catalyzed by CTP:phosphocholine cytidylyltransferase, is diminished by norepinephrine. Norepinephrine 175-189 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 117-156 6541480-5 1984 The dose-response relationships determined for the four peptides in relaxing norepinephrine-induced contraction of rabbit thoracic aorta showed half-maximum relaxation at concentrations ranging from 1.5 X 10(-9) to 2.5 X 10(-9) M. Comparable dose-response relationships were observed in relaxation of carbacol-induced contraction of chick rectum strips as tested with ANF-II and ANF-IV. Norepinephrine 77-91 natriuretic peptide A Rattus norvegicus 368-371 16140489-10 2005 However, during early development, when the chromaffin cells are actively dividing and during aging, when the adrenal medullary cells are known to show hyperplastic lesions, ATP acting through P2Y2 receptors may be involved in other physiological activities, such as proliferation and/or differentiation of the chromaffin cells associated with their adrenaline or noradrenaline phenotype. Norepinephrine 364-377 purinergic receptor P2Y2 Rattus norvegicus 193-197 16083857-1 2005 The human sulfotransferase, SULT1A3, catalyzes specifically the sulfonation of monoamines such as dopamine, epinephrine, and norepinephrine. Norepinephrine 125-139 sulfotransferase family 1A member 3 Homo sapiens 28-35 6541480-5 1984 The dose-response relationships determined for the four peptides in relaxing norepinephrine-induced contraction of rabbit thoracic aorta showed half-maximum relaxation at concentrations ranging from 1.5 X 10(-9) to 2.5 X 10(-9) M. Comparable dose-response relationships were observed in relaxation of carbacol-induced contraction of chick rectum strips as tested with ANF-II and ANF-IV. Norepinephrine 77-91 natriuretic peptide A Rattus norvegicus 379-382 6146513-8 1984 In separate experiments, bilateral stimulation of the splanchnic nerves or pancreatic arterial infusion of norepinephrine to a final concentration of 60 microM decreased ISR and the somatostatin secretion rate (SSR). Norepinephrine 107-121 somatostatin Homo sapiens 182-194 6205029-8 1984 However, mucin release after treatment with SP followed by norepinephrine (NE) was 161% of that caused by NE alone (p less than 0.01) and may reflect an additive response to the independent stimulation of SP and NE receptors. Norepinephrine 59-73 solute carrier family 13 member 2 Rattus norvegicus 9-14 16125539-8 2005 During acute hypoglycemia, CRH KO mice maintained higher plasma glucose levels that correlated with higher plasma norepinephrine and greater glycogen mobilization. Norepinephrine 114-128 corticotropin releasing hormone Mus musculus 27-30 15939797-0 2005 Norepinephrine induces lipolysis in beta1/beta2/beta3-adrenoceptor knockout mice. Norepinephrine 0-14 hemoglobin, beta adult minor chain Mus musculus 42-47 15993437-1 2005 We have previously shown that dimethylphenylpiperazinium (DMPP) increases the release of noradrenaline (NA) from rat hippocampal slices via two distinct mechanisms: a nicotinic acetylcholine receptor (nAChR)-mediated exocytosis and a carrier-mediated release induced by the reversal of NA transporters. Norepinephrine 89-102 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 167-199 15993437-1 2005 We have previously shown that dimethylphenylpiperazinium (DMPP) increases the release of noradrenaline (NA) from rat hippocampal slices via two distinct mechanisms: a nicotinic acetylcholine receptor (nAChR)-mediated exocytosis and a carrier-mediated release induced by the reversal of NA transporters. Norepinephrine 89-102 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 201-206 6146262-3 1984 Likewise, several neuropeptides, e.g., bombesin, corticotropin-releasing factor, thyrotropin-releasing factor, and somatostatin-related peptides, act within the central nervous system to produce differential changes in the relative concentrations of epinephrine and norepinephrine in plasma. Norepinephrine 266-280 gastrin releasing peptide Homo sapiens 39-47 6092250-7 1984 Degradation of released adenosine by addition of adenosine deaminase significantly enhanced the noradrenaline action on glycerol release in both groups of sand rats. Norepinephrine 96-109 adenosine deaminase Rattus norvegicus 49-68 16087140-1 2005 We have documented a pre-junctional beta-2 adrenoceptor mediated reduction in cardiac norepinephrine spillover (CNES) in heart failure patients receiving chronic beta-blockade. Norepinephrine 86-100 adrenoceptor beta 2 Homo sapiens 36-55 15888529-0 2005 Inhibition of perforant path input to the CA1 region by serotonin and noradrenaline. Norepinephrine 70-83 carbonic anhydrase 1 Homo sapiens 42-45 15888529-1 2005 Bath-applied monoamines-dopamine (DA), serotonin (5-HT), and noradrenaline (NE)-strongly suppress the perforant path (PP) input to CA1 hippocampal region with very little effect on the Schaffer collaterals (SC) input. Norepinephrine 61-74 carbonic anhydrase 1 Homo sapiens 131-134 16217122-3 2005 This rhythm is centered around the transcriptional regulation of the AA-NAT by two norepinephrine-inducible transcription factors, the activator CREB (Ca2+/cAMP-response element binding protein) and the inhibitor ICER (inducible cAMP early repressor). Norepinephrine 83-97 aralkylamine N-acetyltransferase Homo sapiens 69-75 16217122-3 2005 This rhythm is centered around the transcriptional regulation of the AA-NAT by two norepinephrine-inducible transcription factors, the activator CREB (Ca2+/cAMP-response element binding protein) and the inhibitor ICER (inducible cAMP early repressor). Norepinephrine 83-97 cAMP responsive element binding protein 1 Homo sapiens 145-149 16217122-3 2005 This rhythm is centered around the transcriptional regulation of the AA-NAT by two norepinephrine-inducible transcription factors, the activator CREB (Ca2+/cAMP-response element binding protein) and the inhibitor ICER (inducible cAMP early repressor). Norepinephrine 83-97 cAMP responsive element binding protein 1 Homo sapiens 151-193 16217122-3 2005 This rhythm is centered around the transcriptional regulation of the AA-NAT by two norepinephrine-inducible transcription factors, the activator CREB (Ca2+/cAMP-response element binding protein) and the inhibitor ICER (inducible cAMP early repressor). Norepinephrine 83-97 cAMP responsive element modulator Homo sapiens 213-217 16217122-3 2005 This rhythm is centered around the transcriptional regulation of the AA-NAT by two norepinephrine-inducible transcription factors, the activator CREB (Ca2+/cAMP-response element binding protein) and the inhibitor ICER (inducible cAMP early repressor). Norepinephrine 83-97 cAMP responsive element modulator Homo sapiens 219-249 16036433-6 2005 The results of autonomic function tests were not different between patients treated with BDNF and placebo, but norepinephrine levels were higher in the BDNF group. Norepinephrine 111-125 brain derived neurotrophic factor Homo sapiens 152-156 16036433-8 2005 The elevation of norepinephrine levels might reflect a non-specific up-regulation, and its association with BDNF an autocrine effect. Norepinephrine 17-31 brain derived neurotrophic factor Homo sapiens 108-112 15944024-3 2005 It is possible that such a function may be revealed by examining the interaction of GAL with norepinephrine (NE), with which it is prominently co-localized. Norepinephrine 93-107 galanin and GMAP prepropeptide Homo sapiens 84-87 15665039-0 2005 Alpha1- and beta1-adrenoceptor signaling fully compensates for beta3-adrenoceptor deficiency in brown adipocyte norepinephrine-stimulated glucose uptake. Norepinephrine 112-126 adrenergic receptor, beta 1 Mus musculus 12-30 15926928-3 2005 Whereas c-Fos expression was increased in Orx neurons after SD, it was increased in MCH neurons after SR. We reasoned that Orx and MCH neurons could be differently modulated by noradrenaline (NA) and accordingly bear different adrenergic receptors (ARs). Norepinephrine 177-190 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 8-13 15741322-5 2005 Normally, this division projects noradrenergic efferents to the cortex that appear to be diminished in Ear2-/- since the cortical concentration of noradrenaline is four times lower in these mice. Norepinephrine 147-160 eosinophil-associated, ribonuclease A family, member 2 Mus musculus 103-107 15677423-5 2004 We show here that sAA activity is increased by acute psychosocial stress (Trier Social Stress Test) and that increases in sAA correlate with increases in norepinephrine. Norepinephrine 154-168 amylase alpha 1A Homo sapiens 18-21 15677423-5 2004 We show here that sAA activity is increased by acute psychosocial stress (Trier Social Stress Test) and that increases in sAA correlate with increases in norepinephrine. Norepinephrine 154-168 amylase alpha 1A Homo sapiens 122-125 6092250-8 1984 Even though the noradrenaline-stimulated lipolytic activity of adipose tissue from normo- and hyperglycemic animals was enhanced in the presence of adenosine deaminase, the hormone resistance of adipose tissue from hyperglycemic sand rats was nevertheless not abolished. Norepinephrine 16-29 adenosine deaminase Rattus norvegicus 148-167 6086876-2 1984 The magnitude and kinetics of the enhanced antibody response to norepinephrine alone, or to norepinephrine in the presence of phentolamine, were more closely mimicked with a beta-2 adrenoceptor agonist (terbutaline) than with a beta-1 adrenoceptor agonist (dobutamine). Norepinephrine 64-78 adrenergic receptor, beta 1 Mus musculus 228-247 6326156-4 1984 Intravenous infusion of ANF in the bilaterally nephrectomized, hexamethonium-treated rat produces only a small transient pressor response, probably due to potentiation of endogenous norepinephrine. Norepinephrine 182-196 natriuretic peptide A Rattus norvegicus 24-27 15548235-9 2004 In contrast, very high positive correlation was observed between noradrenaline level and L(max)-DBP (r = 0.59; P = 0.0005) or L(max)-SBP (r = 0.53; P < 0.002). Norepinephrine 65-78 D-box binding PAR bZIP transcription factor Rattus norvegicus 96-99 6326157-5 1984 By contrast, peripherally administered isoproterenol, norepinephrine or epinephrine, each increased plasma levels of alpha-MSH-LI together with beta-END-LI in a dose-dependent manner. Norepinephrine 54-68 proopiomelanocortin Rattus norvegicus 117-126 6145466-4 1984 alpha-Adrenoceptor agonists such as noradrenaline stimulated kallikrein-like esterase and tonin release in a dose-dependent manner, whereas the beta-adrenoceptor agonist isoprenaline and cholinoceptor agonist methacoline were both inactive. Norepinephrine 36-49 kallikrein 1-related peptidase C2 Rattus norvegicus 90-95 15344912-1 2004 In all mammalian species investigated, noradrenaline activates a beta-adrenoceptor/cAMP/protein kinase A-dependent mechanism to switch on arylalkylamine N-acetyltransferase and melatonin biosynthesis in the pineal gland. Norepinephrine 39-52 aralkylamine N-acetyltransferase Homo sapiens 138-172 15308313-0 2004 Soluble beta-amyloid (A beta) 40 causes attenuation or potentiation of noradrenaline-induced vasoconstriction in rats depending upon the concentration employed. Norepinephrine 71-84 amyloid beta precursor protein Rattus norvegicus 8-28 6145466-5 1984 Noradrenaline-induced release of kallikrein-like esterase and tonin were completely blocked by prior addition of the alpha-adrenoceptor antagonist, phenoxybenzamine. Norepinephrine 0-13 kallikrein 1-related peptidase C2 Rattus norvegicus 62-67 15100092-7 2004 Addition of the sympathetic agonists norepinephrine, isoprenaline, or BRL-37344 (beta(3)-agonist) led to falls in NGF gene expression and secretion by 3T3-L1 adipocytes, as did IL-6 and the PPARgamma agonist rosiglitazone. Norepinephrine 37-51 nerve growth factor Mus musculus 114-117 6144271-1 1984 Norepinephrine is generally regarded as an inhibitor of insulin release. Norepinephrine 0-14 insulin Canis lupus familiaris 56-63 6144271-2 1984 It has been shown, however, that under hyperglycemic circumstances, norepinephrine infused at a high dose may also stimulate insulin secretion. Norepinephrine 68-82 insulin Canis lupus familiaris 125-132 6144271-6 1984 Norepinephrine stimulated insulin, somatostatin, and glucagon secretion without significant changes in either blood glucose concentration or pancreaticoduodenal venous blood flow. Norepinephrine 0-14 insulin Canis lupus familiaris 26-33 6144271-8 1984 Because bilateral cervical vagotomy prevented stimulation of insulin secretion by norepinephrine, central neural pathways must have been involved in the stimulatory process. Norepinephrine 82-96 insulin Canis lupus familiaris 61-68 6539299-0 1984 Atrial natriuretic factor inhibits angiotensin-, norepinephrine-, and potassium-induced vascular contractility. Norepinephrine 49-63 natriuretic peptide A Rattus norvegicus 0-25 6089134-6 1984 These findings are consistent with a hyperactivity of norepinephrine pathways in spontaneously hypertensive rats, leading to a reduced number of cardiac post-junctional secretin/VIP receptors bound to adenylate cyclase. Norepinephrine 54-68 secretin Rattus norvegicus 169-177 6143680-2 1984 retarded the disappearance of noradrenaline induced by the dopamine-beta-hydroxylase (DBH) inhibitor FLA 63, in the hypothalamus, nucleus of the solitary tract (A-2/C-2 area), and lateral reticular nucleus (A-1/C-1 area) regions, while propranolol (20 mg/kg i.p.) Norepinephrine 30-43 UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus 207-214 6141513-3 1984 Acute pretreatment with the selective inhibitor of norepinephrine (NE) synthesis, DU-18288, or with a potent antagonist of presynaptic alpha 2-receptors, mianserin abolished the GH rise induced by CLON (4 /micrograms/Kg iv). Norepinephrine 51-65 somatotropin Canis lupus familiaris 178-180 6316932-1 1983 The rate of noradrenaline-stimulated lipolysis is lower in fat-cells from lactating than from pregnant rats; this difference is eliminated by the addition of adenosine deaminase [Aitchison, Clegg & Vernon (1982) Biochem. Norepinephrine 12-25 adenosine deaminase Rattus norvegicus 158-177 6137369-11 1983 Hypokalaemia and raised levels of noradrenaline are also known to occur under such stressful conditions as acute myocardial infarction, when circulating levels of the endogenous beta 2-adrenoceptor agonist adrenaline are high. Norepinephrine 34-47 adrenoceptor beta 2 Homo sapiens 178-197 6397510-6 1983 Mean plasma concentrations of renin, angiotensin II and aldosterone tended to be lower during prolonged infusion of noradrenaline, but only the fall of renin during the second week was significant in one group of dogs. Norepinephrine 116-129 renin Canis lupus familiaris 30-35 6397510-7 1983 Noradrenaline at higher rates significantly raised blood pressure and increased plasma concentrations of renin and angiotensin II. Norepinephrine 0-13 renin Canis lupus familiaris 105-129 6132592-5 1983 We also observed significant correlations between somatostatin and 5-hydroxyindoleacetic acid and norepinephrine in the CSF. Norepinephrine 98-112 somatostatin Homo sapiens 50-62 6841966-1 1983 Norepinephrine concentration of the whole brain was found to be statistically different between the HBP and LBP mouse stains that had been selectively bred for high and low systolic blood pressure, respectively. Norepinephrine 0-14 lipopolysaccharide binding protein Mus musculus 108-111 6298402-2 1983 Intrarenal infusions of norepinephrine and epinephrine at doses adjusted to reduce renal blood flow by 20 and 50% of baseline values elicited renin release that was not completely blocked by either alpha adrenoceptor blockade with phentolamine or beta adrenoceptor blockade with propranolol. Norepinephrine 24-38 renin Canis lupus familiaris 142-147 6298402-5 1983 These data are consistent with the hypothesis that norepinephrine and epinephrine stimulate renin release by activation of both the renal beta and renal alpha adrenoceptors. Norepinephrine 51-65 renin Canis lupus familiaris 92-97 6341134-0 1983 Differences between the effects of adrenaline and noradrenaline on insulin secretion in the dog. Norepinephrine 50-63 insulin Canis lupus familiaris 67-74 15210450-1 2004 There is evidence that neuropeptide Y (NPY) acts as a neurotransmitter in vascular smooth muscle and is released with norepinephrine from sympathetic nerves. Norepinephrine 118-132 neuropeptide Y Canis lupus familiaris 23-37 15210450-1 2004 There is evidence that neuropeptide Y (NPY) acts as a neurotransmitter in vascular smooth muscle and is released with norepinephrine from sympathetic nerves. Norepinephrine 118-132 neuropeptide Y Canis lupus familiaris 39-42 14751847-2 2004 Subcutaneous administration of adrenomedullin (1.5 microg.kg(-1).h(-1)) for 1 wk inhibited the ANG II-induced (33.3 microg.kg(-1).h(-1) sc) increase in mean arterial pressure by 67% (P < 0.001) but had no effect of norepinephrine-induced (300 microg.kg(-1).h(-1) sc) hypertension. Norepinephrine 218-232 adrenomedullin Rattus norvegicus 31-45 14751847-3 2004 Adrenomedullin enhanced the ANG II-induced improvement in systolic function, resulting in a further 9% increase (P < 0.01) in the left ventricular ejection fraction and 19% increase (P < 0.05) in the left ventricular fractional shortening measured by echocardiography, meanwhile norepinephrine-induced changes in systolic function were remained unaffected. Norepinephrine 285-299 adrenomedullin Rattus norvegicus 0-14 6341134-7 1983 In hyperglycaemic dogs, adrenaline (2 micrograms X kg-1 X min-1) reduced the insulin response and enhanced the hyperglycaemia; noradrenaline (2 micrograms X kg-1 X min-1) markedly increased the insulin response (+ 2250%) without any significant change in blood glucose. Norepinephrine 127-140 insulin Canis lupus familiaris 194-201 6341134-8 1983 Propranolol (0.3 mg/kg, IV) prevented the increase of insulin induced by noradrenaline. Norepinephrine 73-86 insulin Canis lupus familiaris 54-61 6341134-9 1983 These findings show that, in the normal dog, adrenaline and noradrenaline infusions can produce opposite effects on insulin response depending on the experimental conditions. Norepinephrine 60-73 insulin Canis lupus familiaris 116-123 15147203-1 2004 The agonist-induced dynamic regulation of the beta(2)-adrenergic receptor (beta(2)-AR) on living cells was examined by means of fluorescence correlation spectroscopy (FCS) using a fluorescence-labeled arterenol derivative (Alexa-NA) in hippocampal neurons and in alveolar epithelial type II cell line A549. Norepinephrine 201-210 adrenoceptor beta 2 Homo sapiens 75-85 15475682-11 2004 Since many of the alpha2A-AR+/non-cholinergic neurons we detected are likely to be GABAergic cells, our data support the hypothesis that noradrenaline may act via basal forebrain cholinergic and non-cholinergic neurons to influence cortical activity. Norepinephrine 137-150 adrenoceptor alpha 2A Homo sapiens 18-28 6847818-0 1983 Neurotensin-like immunoreactivity in a subpopulation of noradrenaline-containing cells of the cat adrenal gland. Norepinephrine 56-69 neurotensin Bos taurus 0-11 6847818-3 1983 Using immunocytochemical procedures at both light and ultrastructural levels, a neurotensin-like immunoreactive material was localized to a subpopulation of noradrenaline-containing cells quite distinct from the previously described enkephalin-immunoreactive chromaffin cells. Norepinephrine 157-170 neurotensin Bos taurus 80-91 6847818-5 1983 The finding of neurotensin-like immunoreactivity in noradrenaline-containing cells of the cat adrenal medulla provides further evidence in support of the postulated existence of heterogeneous subpopulations of noradrenaline-containing cells and suggests a possible functional interrelationship between neurotensin and catecholamine. Norepinephrine 52-65 neurotensin Bos taurus 15-26 6847818-5 1983 The finding of neurotensin-like immunoreactivity in noradrenaline-containing cells of the cat adrenal medulla provides further evidence in support of the postulated existence of heterogeneous subpopulations of noradrenaline-containing cells and suggests a possible functional interrelationship between neurotensin and catecholamine. Norepinephrine 210-223 neurotensin Bos taurus 15-26 6131439-4 1983 Norepinephrine (20 micrograms ICV) induced feeding was suppressed at the 20 microgram neurotensin dose but not at the 10 microgram or 1 microgram dose. Norepinephrine 0-14 neurotensin Rattus norvegicus 86-97 6131439-9 1983 We conclude that neurotensin may play a role in short-term appetite regulation by a complex interaction with monoamines and neuropeptides, particularly norepinephrine and the kappa opiate agonist, dynorphin. Norepinephrine 152-166 neurotensin Rattus norvegicus 17-28 6295549-0 1982 Effects of norepinephrine and serotonin upon spontaneous activity and responses to mossy fiber stimulation of CA3 neurons in hippocampal slices. Norepinephrine 11-25 carbonic anhydrase 3 Rattus norvegicus 110-113 7159481-6 1982 In contrast, the MAO-B in human platelets deaminated l-norepinephrine more readily than serotonin. Norepinephrine 53-69 monoamine oxidase B Homo sapiens 17-22 7159481-7 1982 Thus, l-norepinephrine, like dopamine, should be regarded as a substrate for both MAO-A and MAO-B in vitro. Norepinephrine 6-22 monoamine oxidase B Homo sapiens 92-97 7159481-8 1982 The prominent role of MAO-B in norepinephrine degradation in primates may need to be considered in interpreting laboratory and clinical studies of clorgyline and other selective MAO-inhibiting drugs. Norepinephrine 31-45 monoamine oxidase B Homo sapiens 22-27 6821292-6 1982 These results suggest that mechanism of the improvement of ataxic gait by TRH may not be sufficiently explained through only changing norepinephrine metabolism. Norepinephrine 134-148 thyrotropin releasing hormone Mus musculus 74-77 7175524-0 1982 Effects of Cd2+, Mn2+, and Al3+ on rat brain synaptosomal uptake of noradrenaline and serotonin. Norepinephrine 68-81 Cd2 molecule Rattus norvegicus 11-14 7175524-2 1982 In the absence of Ca2+, the rank order of inhibition of noradrenaline uptake was: Cd2+ (IC50 = 250 microM) greater than Al3+ (IC50 = 430 microM) greater than Mn2+ (IC50 = 1.50 mM), the IC50 being the concentration of metal ions that gave rise to 50% inhibition of uptake. Norepinephrine 56-69 Cd2 molecule Rattus norvegicus 82-85 7175524-5 1982 Ca2+, at 1 mM, definitely antagonized the inhibitory actions of Cd2+ on noradrenaline and serotonin uptake. Norepinephrine 72-85 Cd2 molecule Rattus norvegicus 64-67 14726440-4 2004 In endothelium-intact arteries, K(+), the thromboxane mimetic U46619, 5-hydroxytryptamine (5-HT), and endothelin-1 (ET-1) induced concentration-dependent contractions, whereas phenylephrine, norepinephrine, and ACTH were without effect. Norepinephrine 191-205 endothelin 1 Bos taurus 102-114 14726440-4 2004 In endothelium-intact arteries, K(+), the thromboxane mimetic U46619, 5-hydroxytryptamine (5-HT), and endothelin-1 (ET-1) induced concentration-dependent contractions, whereas phenylephrine, norepinephrine, and ACTH were without effect. Norepinephrine 191-205 endothelin 1 Bos taurus 116-120 7127680-7 1982 In the veins, arachidonic acid and thrombin caused endothelium-dependent increases in tension during contractions evoked by norepinephrine. Norepinephrine 124-138 coagulation factor II, thrombin Bos taurus 35-43 15164608-1 2004 Following exocytotic release of the biogenic amine neurotransmitters, norepinephrine and dopamine, are removed from the synaptic cleft by the respective transporter, norepinephrine transporter (NET) and dopamine transporter (DAT) located on the plasma membrane. Norepinephrine 70-84 solute carrier family 6 member 3 Homo sapiens 203-223 15164608-1 2004 Following exocytotic release of the biogenic amine neurotransmitters, norepinephrine and dopamine, are removed from the synaptic cleft by the respective transporter, norepinephrine transporter (NET) and dopamine transporter (DAT) located on the plasma membrane. Norepinephrine 70-84 solute carrier family 6 member 3 Homo sapiens 225-228 14981238-2 2004 To validate this structure, we use the HierDock first principles method to predict the ligand-binding sites for epinephrine and norepinephrine and for eight other ligands, including agonists and antagonists to beta 2 AR and ligands not observed to bind to beta 2 AR. Norepinephrine 128-142 adrenoceptor beta 2 Homo sapiens 256-265 6283915-2 1982 When given to slices maintained at 37 degrees C, the beta-agonists isoproterenol (ISP) and norepinephrine stimulated renin release from the slices. Norepinephrine 91-105 renin Canis lupus familiaris 117-122 6283920-6 1982 Norepinephrine reversed the suppressive effect of bombesin but not that of cholecystokinin. Norepinephrine 0-14 gastrin releasing peptide Homo sapiens 50-58 14736546-7 2004 NEFA and insulin concentrations increased early and progressively in DCM in association with increased norepinephrine concentrations and progressive hemodynamic impairment. Norepinephrine 103-117 insulin Canis lupus familiaris 9-16 7062033-3 1982 The release rates of noradrenaline and dopamine into artificial CSF perfusates were 38 +/- 6 and 46 +/- 6 pg/h (225 +/- 36 and 301 +/- 39 fmol/h), respectively; when 0.5 mM amphetamine was added to the CSF, the release rates of noradrenaline and dopamine increased to 176 +/- 50 and 1183 +/- 453 ph/h (1041 +/- 296 and 7732 +/- 2961 fmol/h), respectively. Norepinephrine 21-34 colony stimulating factor 2 Rattus norvegicus 64-67 14697247-6 2004 Increases in haptoglobin mRNA level were also induced by dexamethasone, noradrenaline, isoprenaline, and a beta3-adrenoceptor agonist. Norepinephrine 72-85 haptoglobin Mus musculus 13-24 7062033-3 1982 The release rates of noradrenaline and dopamine into artificial CSF perfusates were 38 +/- 6 and 46 +/- 6 pg/h (225 +/- 36 and 301 +/- 39 fmol/h), respectively; when 0.5 mM amphetamine was added to the CSF, the release rates of noradrenaline and dopamine increased to 176 +/- 50 and 1183 +/- 453 ph/h (1041 +/- 296 and 7732 +/- 2961 fmol/h), respectively. Norepinephrine 21-34 colony stimulating factor 2 Rattus norvegicus 202-205 6811784-1 1982 Rolling Mouse Nagoya (RMN), weaver and reeler mice were examined for the clinical effectiveness of drugs (thyrotropin releasing hormone (TRH), reserpine, L-dopa) that are reported to facilitate or alter the metabolic system of noradrenaline (NA). Norepinephrine 227-240 thyrotropin releasing hormone Mus musculus 106-135 6212052-9 1982 The effect of noradrenaline appeared to be exerted through a beta- rather than an alpha-type of adrenoceptor. Norepinephrine 14-27 amyloid beta precursor protein Rattus norvegicus 59-65 14678390-3 2004 The potency and intrinsic activity of amidephrine and Ro 115-1240 relative to noradrenaline were determined in native and cell-based assays using human recombinant alpha1-ARs; they acted as selective alpha1A/1L-AR full and partial agonists, respectively. Norepinephrine 78-91 calcium voltage-gated channel subunit alpha1 A Homo sapiens 200-207 7071077-4 1982 The putative satiety hormones, bombesin (10 micrograms/kg; subcutaneously) and cholecystokinin octapeptide (10 micrograms/kg; subcutaneously) also reduced norepinephrine induced eating, as did ICV administration of calcitonin (2 units). Norepinephrine 155-169 gastrin releasing peptide Homo sapiens 31-39 6282271-7 1982 The noradrenaline-stimulated lipolysis rate rose above the virgin rate during pregnancy and fell below it during lactation; inclusion of adenosine deaminase in incubations abolished these differences in response to noradrenaline. Norepinephrine 215-228 adenosine deaminase Rattus norvegicus 137-156 15554782-4 2004 One strategy for patients who have not responded to treatment with an SRI is to switch them to a serotonin-norepinephrine reuptake inhibitor, because some patients may respond better to agents that target multiple systems. Norepinephrine 107-121 sorcin Homo sapiens 70-73 15545008-9 2004 In the rat brain, the most prominent observation was the revelation of all catecholamine cells (dopamine, norepinephrine, epinephrine) by the flotillin-1 antibody (1:100 dilution). Norepinephrine 106-120 flotillin 1 Rattus norvegicus 142-153 7054638-0 1982 Neurotensin-induced release of endogenous noradrenaline from rat hypothalamic slices. Norepinephrine 42-55 neurotensin Rattus norvegicus 0-11 6175823-0 1982 Prolonged infusion of norepinephrine in the conscious dog: effects on blood pressure, heart rate, renin, angiotensin II, and aldosterone. Norepinephrine 22-36 renin Canis lupus familiaris 98-103 6127639-2 1982 The catecholamines dopamine (DA) and norepinephrine (NE) inhibited the release of alpha-MSH from pituitary glands incubated in vitro. Norepinephrine 37-51 proopiomelanocortin Rattus norvegicus 82-91 7040635-5 1981 Infusion noradrenaline by either route resulted in dose-related rises in plasma renin activity. Norepinephrine 9-22 renin Canis lupus familiaris 80-85 7028613-1 1981 Sodium depletion, a maneuver that is accompanied by a 14-fold elevation of plasma renin activity (PRA), alters the norepinephrine concentration of the canine area postrema (AP), a circumventricular organ of the 4th ventricle known to be sensitive to circulating angiotensin II. Norepinephrine 115-129 renin Canis lupus familiaris 82-87 6274461-0 1981 Insulin-induced enhancement of uptake of noradrenaline in atrial strips. Norepinephrine 41-54 insulin Cavia porcellus 0-7 6274461-3 1981 3 The response os isolated atria to noradrenaline was significantly reduced in the presence of insulin. Norepinephrine 36-49 insulin Cavia porcellus 95-102 6274461-7 1981 6 The ability of insulin to facilitate uptake of noradrenaline would be expected to cause a decrease in the amount of the amine reaching the receptors, thus leading to a diminished response to this amine. Norepinephrine 49-62 insulin Cavia porcellus 17-24 6274461-8 1981 This may explain, at least in part, insulin-induced subsensitivity to noradrenaline. Norepinephrine 70-83 insulin Cavia porcellus 36-43 7320735-1 1981 The circadian release of norepinephrine from nerve terminals in the pineal gland drives acetyl-CoA:serotonin N-acetyltransferase (NAT; EC 2.3.1.5) activity in the adult pineal from a daytime low to a nighttime high. Norepinephrine 25-39 aralkylamine N-acetyltransferase Homo sapiens 99-128 7320735-1 1981 The circadian release of norepinephrine from nerve terminals in the pineal gland drives acetyl-CoA:serotonin N-acetyltransferase (NAT; EC 2.3.1.5) activity in the adult pineal from a daytime low to a nighttime high. Norepinephrine 25-39 bromodomain containing 2 Homo sapiens 130-133 6271668-1 1981 The effect of continuous intrarenal infusion of norepinephrine, isoproterenol, and methoxamine on renin release was studied in the uninephrectomized conscious dog. Norepinephrine 48-62 renin Canis lupus familiaris 98-103 6271668-2 1981 Chronic intrarenal infusion of norepinephrine produced a biphasic curve of plasma renin activity (PRA) and a sustained 25 mm Hg increase in mean arterial pressure (MAP). Norepinephrine 31-45 renin Canis lupus familiaris 82-87 6271374-0 1981 Effects of tonin on the response to norepinephrine by the aortic strip of the hypertensive rat. Norepinephrine 36-50 kallikrein 1-related peptidase C2 Rattus norvegicus 11-16 7017342-4 1981 Acute replacement (8 units PZI) 12hr before the measurements resulted in resting and noradrenaline-stimulated values for VO2 that were similar to those of non-diabetic cafeteria rats. Norepinephrine 85-98 serpin family A member 10 Rattus norvegicus 27-30 6270688-1 1981 Studies of the adrenergic regulation of cyclic GMP in the pineal gland show that (-)-norepinephrine stimulates cyclic GMP primarily in pineal cells, rather than in nerve endings as previously thought. Norepinephrine 81-99 5'-nucleotidase, cytosolic II Homo sapiens 47-50 6270688-1 1981 Studies of the adrenergic regulation of cyclic GMP in the pineal gland show that (-)-norepinephrine stimulates cyclic GMP primarily in pineal cells, rather than in nerve endings as previously thought. Norepinephrine 81-99 5'-nucleotidase, cytosolic II Homo sapiens 118-121 6266953-2 1981 Tonin potentiates the effect of norepinephrine (NE) in the rat mesenteric artery preparation and in the aortic strips from normal and hypertensive rats. Norepinephrine 32-46 kallikrein 1-related peptidase C2 Rattus norvegicus 0-5 7011963-8 1981 The CSF norepinephrine was related inversely to the CSF sodium concentration and directly to plasma renin activity. Norepinephrine 8-22 renin Canis lupus familiaris 100-105 6109792-6 1981 Both carbachol- and norepinephrine-mediated gastrin release are modified by somatostatin and adenosine. Norepinephrine 20-34 gastrin Rattus norvegicus 44-51 14656380-7 2003 Agonist competition assays with [3H]DHA showed the following rank order of potency: isoproterenol>epinephrine> norepinephrine, consistent with beta2AR interaction. Norepinephrine 117-131 adrenoceptor beta 2 Homo sapiens 149-156 7253345-5 1981 C8-CCK (10(-9) g/ml) potentiated both contractile and relaxing responses to noradrenaline, in the gallbladder. Norepinephrine 76-89 cholecystokinin Cavia porcellus 3-6 12596890-2 2002 Three endogenous natriuretic peptide ligands (natriuretic peptide, ANP; brain natriuretic peptide, BNP; C-type natriuretic peptide, CNP) produced a concentration-dependent relaxation in de-endothelialized guinea-pig aorta pre-contracted by noradrenaline (NA), with a potency order of ANP > or = BNP >> CNP. Norepinephrine 240-253 2',3'-cyclic-nucleotide 3'-phosphodiesterase Cavia porcellus 132-135 7253345-9 1981 These results suggest that C8-CCK enhances the contractile and relaxing responses to noradrenaline, and that prostaglandins act in a similar way on the postsynaptic response and, in addition, inhibit presynaptically the release of noradrenaline in the gallbladder. Norepinephrine 85-98 cholecystokinin Cavia porcellus 30-33 12145319-5 2002 The amisyn coil domain prevents the SNAP-25 C-terminally mediated rescue of botulinum neurotoxin E inhibition of norepinephrine exocytosis in permeabilized PC12 cells to a greater extent than it prevents the regular exocytosis of these vesicles. Norepinephrine 113-127 synaptosome associated protein 25 Rattus norvegicus 36-43 33443233-2 2020 The fight-or-flight response induces the release of the stress response hormone norepinephrine to stimulate beta-adrenergic receptors, cAMP production, and protein kinase A activity to augment Ca2+ influx through Cav1.2 and, consequently, cardiomyocyte contractility. Norepinephrine 80-94 calcium voltage-gated channel subunit alpha1 C Homo sapiens 213-219 12170059-0 2002 Nicotinic acetylcholine receptor regulation of spinal norepinephrine release. Norepinephrine 54-68 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 0-32 12170059-3 2002 This study tested whether nAChR agonists stimulate spinal release of the neurotransmitter norepinephrine either by direct actions on noradrenergic terminals or indirectly by stimulating release of other neurotransmitters to induce norepinephrine release. Norepinephrine 90-104 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 26-31 11853869-5 2002 administration of NMU on mean arterial pressure (MAP), heart rate (HR), and plasma norepinephrine in conscious rats. Norepinephrine 83-97 neuromedin U Rattus norvegicus 18-21 11853869-7 2002 In contrast, plasma norepinephrine increased only with a high dose of neuromedin U. Norepinephrine 20-34 neuromedin U Rattus norvegicus 70-82 12020731-9 2002 Both sexes generally showed increased in hippocampal (CA3) norepinephrine levels in their respective stress groups. Norepinephrine 59-73 carbonic anhydrase 3 Rattus norvegicus 54-57 33291181-7 2021 A reaction kinetic model was developed that provided a quantitative description of norepinephrine-facilitated extracellular Hsp70 release, congruent with the experimental data. Norepinephrine 83-97 heat shock protein family A (Hsp70) member 4 Homo sapiens 124-129 11922898-11 2002 In parallel, norepinephrine caused a translocation of PKC-alpha and PKC-delta into the particular fractions and this effect of norepinephrine was also enhanced by co-presence of NPY. Norepinephrine 13-27 protein kinase C, alpha Rattus norvegicus 54-63 11922898-11 2002 In parallel, norepinephrine caused a translocation of PKC-alpha and PKC-delta into the particular fractions and this effect of norepinephrine was also enhanced by co-presence of NPY. Norepinephrine 127-141 protein kinase C, alpha Rattus norvegicus 54-63 11880481-0 2002 Activation by serotonin and noradrenaline of vasopressin and oxytocin expression in the mouse paraventricular and supraoptic nuclei. Norepinephrine 28-41 oxytocin Mus musculus 61-69 11880481-1 2002 Noradrenaline and serotonin are known to control arginine-vasopressin (AVP) and oxytocin (OT) secretion in the systemic circulation. Norepinephrine 0-13 oxytocin Mus musculus 80-88 11927164-10 2002 The time course of onset of presynaptic inhibition of norepinephrine release was much faster for the alpha(2A)-receptor than for the alpha(2C)-subtype. Norepinephrine 54-68 adrenergic receptor, alpha 2c Mus musculus 133-141 32948909-8 2020 Pharmacologic strategies include abrogating the beta2-adrenergic receptor signaling pathway to antagonize epinephrine and norepinephrine action on tumor and immune cells. Norepinephrine 122-136 adrenoceptor beta 2 Homo sapiens 48-73 11927164-11 2002 After prolonged stimulation with norepinephrine, presynaptic alpha(2C)-adrenergic receptors were desensitized. Norepinephrine 33-47 adrenergic receptor, alpha 2c Mus musculus 61-69 12127097-17 2002 Estradiol treatment increased norepinephrine levels in CA3 region of the hippocampus, mitigating stress-dependent changes. Norepinephrine 30-44 carbonic anhydrase 3 Rattus norvegicus 55-58 12127097-21 2002 In relation to interactions between stress and estradiol on cognition and anxiety, changes in the prefrontal cortex dopaminergic system, dentate gyrus serotonergic system, and norepinephrine levels in the CA3 region appear important. Norepinephrine 176-190 carbonic anhydrase 3 Rattus norvegicus 205-208 12448081-8 2002 The co-localization of GAL and dopamine beta-hydroxylase (D beta H--a key enzyme of the noradrenaline synthesis pathway) in perivascular nerve fibers could lead to considerable vasospasms in the pancreas, resulting in deeper hypoxia of the organ. Norepinephrine 88-101 galanin and GMAP prepropeptide Homo sapiens 23-26 11602687-8 2001 Prazosin, 5-methyl-urapidil, and 2-[2,6-dimethoxyphenoxyethyl]aminomethyl)-1,4-benzodioxane (WB 4101) shifted the potency of norepinephrine concentration dependently giving pA2 values of 9.4, 8.9, and 10.1, respectively, showing the presence of the alpha1A-subtype in these arteries. Norepinephrine 125-139 calcium voltage-gated channel subunit alpha1 A Homo sapiens 249-256 33437747-2 2020 Epinephrine and norepinephrine are stress hormones which affect many cells, including immune cells through interaction with adrenergic receptors, mainly beta2-adrenergic receptor. Norepinephrine 16-30 adrenoceptor beta 2 Homo sapiens 153-178 11479288-2 2001 Activation of CaM kinase II in norepinephrine-stimulated vascular smooth muscle cells leads to activation of cPLA(2) and arachidonic acid release. Norepinephrine 31-45 phospholipase A2 group IVA Homo sapiens 109-116 11479288-4 2001 Phosphopeptide mapping studies with cPLA(2) from norepinephrine-stimulated smooth muscle cells indicates that phosphorylation of cPLA(2) on Ser-515, but not on Ser-505 or Ser-727, occurs in vivo. Norepinephrine 49-63 phospholipase A2 group IVA Homo sapiens 36-43 32981364-10 2020 Collectively, our findings support the existence of a norepinephrine-activated alpha1-adrenoceptor gated pathway that relies on WNK/SPAK/OxSR1 signaling to regulate NCC activity in SSH. Norepinephrine 54-68 serine threonine kinase 39 Rattus norvegicus 132-136 11479288-4 2001 Phosphopeptide mapping studies with cPLA(2) from norepinephrine-stimulated smooth muscle cells indicates that phosphorylation of cPLA(2) on Ser-515, but not on Ser-505 or Ser-727, occurs in vivo. Norepinephrine 49-63 phospholipase A2 group IVA Homo sapiens 129-136 32914279-9 2020 Also, the silencing of dTRH in the TG mice normalized urine noradrenaline excretion, supporting the view that the cardiovascular effects of TRH involve the sympathetic system. Norepinephrine 60-73 thyrotropin releasing hormone Mus musculus 24-27 33117176-3 2020 They are related to two other adrenergic receptor families that also bind norepinephrine and epinephrine, the beta- and alpha2-, each with three subtypes (beta1, beta2, beta3, alpha2A, alpha2B, alpha2C). Norepinephrine 74-88 immunoglobulin kappa variable 2D-30 Homo sapiens 155-160 32544482-9 2020 These findings suggest that under conditions of increased sympathetic tone, such as those related to stress, noradrenaline may sensitize masticatory muscle nociceptors to increase pain and desensitize muscle proprioceptors to alter muscle tone, through activation of alpha1 receptors. Norepinephrine 109-122 immunoglobulin kappa variable 2D-30 Homo sapiens 267-273 32702980-11 2020 Structural analysis revealed that inhibitor 3 binds to hPNMT by filling the catalytic binding pockets for the cofactor (SAM) and the substrate (norepinephrine) binding sites. Norepinephrine 144-158 protein phosphatase 1 regulatory inhibitor subunit 11 Homo sapiens 34-45 32823962-0 2020 Simple and Cost-Effective Electrochemical Method for Norepinephrine Determination Based on Carbon Dots and Tyrosinase. Norepinephrine 53-67 tyrosinase Homo sapiens 107-117 32332112-7 2020 These effects may result from coordinated regulation of bladder afferent activity via M3 muscarinic inhibition and beta3 adrenoreceptor activation by norepinephrine elevation due to norepinephrine transporter inhibition. Norepinephrine 150-164 adrenoceptor beta 3 Rattus norvegicus 115-135 32319652-0 2020 The sympathetic transmitter norepinephrine inhibits VSMC proliferation induced by TGFbeta by suppressing the expression of the TGFbeta receptor ALK5 in aorta remodeling. Norepinephrine 28-42 transforming growth factor alpha Rattus norvegicus 82-89 32319652-0 2020 The sympathetic transmitter norepinephrine inhibits VSMC proliferation induced by TGFbeta by suppressing the expression of the TGFbeta receptor ALK5 in aorta remodeling. Norepinephrine 28-42 transforming growth factor alpha Rattus norvegicus 127-134 32319652-0 2020 The sympathetic transmitter norepinephrine inhibits VSMC proliferation induced by TGFbeta by suppressing the expression of the TGFbeta receptor ALK5 in aorta remodeling. Norepinephrine 28-42 transforming growth factor, beta receptor 1 Rattus norvegicus 144-148 32319652-2 2020 The present study aimed to explore the impact of the sympathetic neurotransmitter norepinephrine (NE) on transforming growth factor (TGF) beta signaling and the role of NE in aortic remodeling. Norepinephrine 82-96 transforming growth factor alpha Rattus norvegicus 105-142 32406234-6 2020 Arrays of HD-CNTf rods microelectrode were applied to detect neurotransmitters i.e. dopamine (DA), serotonin (5-HT), epinephrine (Epn) and nor-epinephrine (Nor-epn) using voltammetric techniques. Norepinephrine 139-154 ciliary neurotrophic factor Homo sapiens 13-17 32486305-0 2020 Norepinephrine Inhibits the Proliferation of Human Bone Marrow-Derived Mesenchymal Stem Cells via beta2-Adrenoceptor-Mediated ERK1/2 and PKA Phosphorylation. Norepinephrine 0-14 adrenoceptor beta 2 Homo sapiens 98-116 32152116-5 2020 Interestingly, CD300f-/- mice displayed several characteristic MDD traits such as augmented microglial numbers, increased interleukin 6 and interleukin 1 receptor antagonist messenger RNA, alterations in synaptic strength, and noradrenaline-dependent and persistent depressive-like and anhedonic behaviors in females. Norepinephrine 227-240 CD300 molecule like family member f Homo sapiens 15-21 31818916-7 2020 In rodent brain, the compound time- and dose-dependently bound to MAGL, indirectly led to CB1 occupancy by raising 2-AG levels, and raised norepinephrine levels in cortex. Norepinephrine 139-153 monoglyceride lipase Homo sapiens 66-70 31689515-9 2020 The in vitro investigations of the effects of noradrenaline on microglia showed that noradrenaline through beta-adrenoceptor may influence Nrf2 expression also via CX3CR1-independent route. Norepinephrine 85-98 C-X3-C motif chemokine receptor 1 Rattus norvegicus 164-170 32140623-3 2020 Inhibition of SGLT2 prevented weight gain, reduced blood pressure, significantly reduced elevations of tyrosine hydroxylase and norepinephrine, and protects against endothelial dysfunction. Norepinephrine 128-142 solute carrier family 5 (sodium/glucose cotransporter), member 2 Mus musculus 14-19 31811856-3 2020 Noradrenaline increased alpha1B-adrenergic receptor-Rab5 interaction, which was blocked by paroxetine and by expression of the dominant-negative GRK2 mutant. Norepinephrine 0-13 adrenoceptor alpha 1B Homo sapiens 24-51 11373287-2 2001 Botulinum neurotoxin E cleaves the C-terminal coil of SNAP-25, inhibiting exocytosis of norepinephrine from permeabilized PC12 cells. Norepinephrine 88-102 synaptosome associated protein 25 Rattus norvegicus 54-61 31910209-13 2020 Systemic 6-OHDA decreased adrenal medulla expression of catecholamine producing enzymes (TH and aromatic L-amino acid decarboxylase) and circulating levels of norepinephrine, which were attenuated by PPARgamma-activation. Norepinephrine 159-173 peroxisome proliferator activated receptor gamma Macaca mulatta 200-209 31152452-0 2019 Cx32 mediates norepinephrine-promoted EGFR-TKI resistance in a gap junction-independent manner in non-small-cell lung cancer. Norepinephrine 14-28 gap junction protein beta 1 Homo sapiens 0-4 31152452-5 2019 In the present study, we show that the stress hormone norepinephrine (NE) promotes Afatinib resistance by upregulating Cx32 expression. Norepinephrine 54-68 gap junction protein beta 1 Homo sapiens 119-123 31649525-0 2019 Alpha1-Adrenergic Receptor Mediated Long-Term Depression at CA3-CA1 Synapses Can Be Induced via Accumulation of Endogenous Norepinephrine and Is Preserved Following Noradrenergic Denervation. Norepinephrine 123-137 carbonic anhydrase 3 Rattus norvegicus 60-67 11429392-11 2001 These results show that contractile responses to noradrenaline in human skeletal muscle resistance arteries are predominantly mediated by the alpha(1A)-adrenoceptor subtype with a minor population of an unknown alpha(1)-adrenoceptor subtype. Norepinephrine 49-62 calcium voltage-gated channel subunit alpha1 A Homo sapiens 142-150 18239728-6 2001 The beta agonist isoproterenol mimicked the effect of norepinephrine on oscillation frequency and truncated the responses suggesting that a beta-adrenergic upregulation of H current modifies the internal structure (frequency) of thalamic oscillations. Norepinephrine 54-68 amyloid beta precursor protein Rattus norvegicus 138-144 11426840-3 2001 administered CRF and urocortin (0.5, 1.5 and 3.0 nmol/animal) effectively and dose-dependently elevated plasma levels of adrenaline and noradrenaline, and the effect of urocortin was almost the same as that of CRF. Norepinephrine 136-149 urocortin Rattus norvegicus 21-30 30930287-1 2019 Beta-adrenergic receptor (b-AR) activation by noradrenaline (NA) enhances memory formation and long-term potentiation (LTP), a form of synaptic plasticity characterized by an activity-dependent increase in synaptic strength. Norepinephrine 46-59 adrenoceptor beta 2 Homo sapiens 0-24 11306720-0 2001 Molecular mechanism for agonist-promoted alpha(2A)-adrenoceptor activation by norepinephrine and epinephrine. Norepinephrine 78-92 adrenoceptor alpha 2A Homo sapiens 41-63 11306460-6 2001 In summary, norepinephrine-induced locomotion of SW 480 cells is beta2-adrenoceptor mediated and distinct from spontaneous locomotion concerning the PTK involvement. Norepinephrine 12-26 adrenoceptor beta 2 Homo sapiens 65-83 30930287-1 2019 Beta-adrenergic receptor (b-AR) activation by noradrenaline (NA) enhances memory formation and long-term potentiation (LTP), a form of synaptic plasticity characterized by an activity-dependent increase in synaptic strength. Norepinephrine 46-59 adrenoceptor beta 2 Homo sapiens 26-30 30636447-8 2019 Increasing Pck2 was sufficient to promote hypertrophic growth similar to that caused by increasing Lin28a, whereas knocking down Pck2 attenuated norepinephrine-induced cardiac hypertrophy. Norepinephrine 145-159 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 129-133 11259564-5 2001 The antinociceptive potency of [Dmt1]DALDA far exceeded its affinity and potency at the mu-opioid receptor and may be explained by its ability to inhibit norepinephrine (NE) uptake in spinal cord synaptosomes. Norepinephrine 154-168 RoBo-1 Rattus norvegicus 32-36 30651375-1 2019 Beta-adrenergic receptor (beta-AR) activation by norepinephrine (NE) enhances memory and stabilizes long-term potentiation (LTP), a form of synaptic plasticity believed to underlie some forms of hippocampal memory. Norepinephrine 49-63 adrenergic receptor, beta 1 Mus musculus 0-24 11262584-5 2001 In clinical studies carbonic anhydrase I from erythrocytes increased by 87% after noradrenaline administration, by 71% after orciprenaline and by 82% after isoprenaline. Norepinephrine 82-95 carbonic anhydrase 1 Homo sapiens 20-40 11171092-0 2001 As the proliferation promoter noradrenaline induces expression of ICER (induced cAMP early repressor) in proliferative brown adipocytes, ICER may not be a universal tumour suppressor. Norepinephrine 30-43 cAMP responsive element modulator Homo sapiens 66-70 11171092-0 2001 As the proliferation promoter noradrenaline induces expression of ICER (induced cAMP early repressor) in proliferative brown adipocytes, ICER may not be a universal tumour suppressor. Norepinephrine 30-43 cAMP responsive element modulator Homo sapiens 72-100 11171092-0 2001 As the proliferation promoter noradrenaline induces expression of ICER (induced cAMP early repressor) in proliferative brown adipocytes, ICER may not be a universal tumour suppressor. Norepinephrine 30-43 cAMP responsive element modulator Homo sapiens 137-141 11171092-4 2001 In brown adipocytes in primary culture, ICER gene expression was induced by noradrenaline (norepinephrine) not only in the mature state (where noradrenaline potentiates differentiation), but also in the proliferative state of the cell cultures (where noradrenaline enhances cell proliferation). Norepinephrine 76-89 cAMP responsive element modulator Homo sapiens 40-44 11171092-4 2001 In brown adipocytes in primary culture, ICER gene expression was induced by noradrenaline (norepinephrine) not only in the mature state (where noradrenaline potentiates differentiation), but also in the proliferative state of the cell cultures (where noradrenaline enhances cell proliferation). Norepinephrine 91-105 cAMP responsive element modulator Homo sapiens 40-44 11171092-4 2001 In brown adipocytes in primary culture, ICER gene expression was induced by noradrenaline (norepinephrine) not only in the mature state (where noradrenaline potentiates differentiation), but also in the proliferative state of the cell cultures (where noradrenaline enhances cell proliferation). Norepinephrine 143-156 cAMP responsive element modulator Homo sapiens 40-44 11171092-4 2001 In brown adipocytes in primary culture, ICER gene expression was induced by noradrenaline (norepinephrine) not only in the mature state (where noradrenaline potentiates differentiation), but also in the proliferative state of the cell cultures (where noradrenaline enhances cell proliferation). Norepinephrine 143-156 cAMP responsive element modulator Homo sapiens 40-44 30651375-1 2019 Beta-adrenergic receptor (beta-AR) activation by norepinephrine (NE) enhances memory and stabilizes long-term potentiation (LTP), a form of synaptic plasticity believed to underlie some forms of hippocampal memory. Norepinephrine 49-63 adrenergic receptor, beta 1 Mus musculus 26-33 30325031-4 2019 The order of Kb values between drugs such as adrenaline hydrochloride, norepinephrine bitartrate, and propranolol hydrochloride with beta2 -AR is well consistent with that reported in the literature. Norepinephrine 71-96 adrenoceptor beta 2 Homo sapiens 133-142 11740147-8 2001 CONCLUSIONS: These results reveal that alcohol is able to induce hypertension and provide evidence that alcohol inhibits the transcriptions of both 11beta-HSD2 and CYP11B2 in the vasculature, leading to lower aldosterone and higher corticosterone production in vessels, and increased vasoconstrictor responses to norepinephrine. Norepinephrine 313-327 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 148-159 11740147-8 2001 CONCLUSIONS: These results reveal that alcohol is able to induce hypertension and provide evidence that alcohol inhibits the transcriptions of both 11beta-HSD2 and CYP11B2 in the vasculature, leading to lower aldosterone and higher corticosterone production in vessels, and increased vasoconstrictor responses to norepinephrine. Norepinephrine 313-327 cytochrome P450, family 11, subfamily b, polypeptide 2 Rattus norvegicus 164-171 11145760-10 2000 Immunoreactive G-protein coupled receptor kinase-2 level was increased in denervated rabbits receiving norepinephrine. Norepinephrine 103-117 beta-adrenergic receptor kinase 1 Oryctolagus cuniculus 15-50 11012844-4 2000 Intraperitoneal preadministration of a selective nonpeptidic CRFR1 antagonist, CRA1000, completely blocked the conditioned fear-induced release of noradrenaline. Norepinephrine 147-160 corticotropin releasing hormone receptor 1 Rattus norvegicus 61-66 11012844-5 2000 These results suggest that CRFR1 is involved in the release of noradrenaline in the hypothalamic PVN induced by conditioned fear. Norepinephrine 63-76 corticotropin releasing hormone receptor 1 Rattus norvegicus 27-32 11108138-3 2000 The addition of norepinephrine (NE), isoproterenol (a beta1/beta2-adrenergic receptor (AR) agonist) and iodoclonidine (an alpha2-AR agonist) stimulated the expression of the ANG-GH fusion gene in a dose-dependent manner, whereas the addition of epinephrine and phenylephrine (alpha1-AR agonist) had no effect. Norepinephrine 16-30 adrenoceptor beta 2 Homo sapiens 60-85 10910482-7 2000 Similarly, incubation of PBMCs (T1) with plasma obtained after CPB (T2) as well as addition of IL-10 or norepinephrine in concentrations present in plasma after CPB led to a reduced lipopolysaccharide-stimulated TNF-alpha and an increased IL-10 response. Norepinephrine 104-118 interleukin 10 Homo sapiens 239-244 10910482-11 2000 Although norepinephrine fails to induce a cytokine response in the absence of other stimuli, its administration seems to augment the antiinflammatory IL-10 response while attenuating the TNF-alpha response. Norepinephrine 9-23 interleukin 10 Homo sapiens 150-155 10854049-1 2000 Rab3B is a monomeric GTPase that modulates norepinephrine secretion when expressed in PC12 neuroendocrine cells. Norepinephrine 43-57 RAB3B, member RAS oncogene family Rattus norvegicus 0-5 10854049-4 2000 ZO-1 localization was not appreciably affected by the expression of a GTP binding mutant of rab3B (N135I) that stimulates norepinephrine secretion by PC12 cells. Norepinephrine 122-136 RAB3B, member RAS oncogene family Rattus norvegicus 92-97 10775486-2 2000 beta(1)-AR signaling, by the endogenous neurotransmitter norepinephrine, is central to the regulation of myocardial contractility. Norepinephrine 57-71 adrenergic receptor, beta 1 Mus musculus 0-10 10784001-7 2000 NPY and PYY, but not PP, SP, CCK or GIP, inhibited the increase in glucose release by glucagon and noradrenaline. Norepinephrine 99-112 peptide YY Rattus norvegicus 8-11 10784001-9 2000 Only portal NPY and PYY enhanced slightly the noradrenaline-dependent reduction of portal flow. Norepinephrine 46-59 peptide YY Rattus norvegicus 20-23 10784001-11 2000 NPY and PYY act as signal factors of the absorptive phase function as antagonists of the postabsorptive glucose regulatory hormones glucagon and noradrenaline. Norepinephrine 145-158 peptide YY Rattus norvegicus 8-11 10629458-8 2000 A small decrease in IFN-gamma production and an increase in IL-10, IL-4, and IL-5 production were also observed with norepinephrine. Norepinephrine 117-131 interleukin 10 Homo sapiens 60-65 10717436-9 2000 These results indicate that during acute thalamic hypoxia an increased release of noradrenaline, serotonin, histamine and nitric oxide is responsible for transforming I(h) into an instantaneously activating current via cyclic AMP- and cyclic GMP-mediated mechanisms. Norepinephrine 82-95 5'-nucleotidase, cytosolic II Homo sapiens 242-245 10651063-0 1999 Atrial natriuretic factor inhibits norepinephrine biosynthesis and turnover in the rat hypothalamus. Norepinephrine 35-49 natriuretic peptide A Rattus norvegicus 0-25 10651063-1 1999 We have previously reported that atrial natriuretic factor (ANF) increased neuronal norepinephrine (NE) uptake and reduced basal and evoked neuronal NE release. Norepinephrine 84-98 natriuretic peptide A Rattus norvegicus 33-58 11270969-4 1999 Norepinephrine-induced increase of [Ca2+]i was inhibited by the tyrosine kinase inhibitors quercetin and tyrphostin by 23.8% and 21.4%, respectively, but the accumulation of [3H]InsPs induced by norepinephrine was not. Norepinephrine 195-209 TXK tyrosine kinase Homo sapiens 64-79 11270969-5 1999 The activity of the plasma-associated tyrosine kinase was increased to (1.73 +/- 0.72)-fold over the control by norepinephrine 10 mumol.L-1. Norepinephrine 112-126 TXK tyrosine kinase Homo sapiens 38-53 10454495-8 1999 Contractile responses of the rabbit saphenous vein to both 5-HT(1A) receptor agonists were markedly inhibited by prazosin and dextrally shifted by WAY 100635, supporting the idea that the 5-HT(1A) receptor agonists were activating presynaptic 5-HT(1A) receptors to enhance norepinephrine release even in the absence of field stimulation. Norepinephrine 273-287 5-hydroxytryptamine receptor 1A Oryctolagus cuniculus 188-195 10454495-8 1999 Contractile responses of the rabbit saphenous vein to both 5-HT(1A) receptor agonists were markedly inhibited by prazosin and dextrally shifted by WAY 100635, supporting the idea that the 5-HT(1A) receptor agonists were activating presynaptic 5-HT(1A) receptors to enhance norepinephrine release even in the absence of field stimulation. Norepinephrine 273-287 5-hydroxytryptamine receptor 1A Oryctolagus cuniculus 188-195 10454495-10 1999 These observations suggested that serotonergic nerves or other cell types in the saphenous vein are activated by field stimulation to release serotonin, which in turn activates presynaptic 5-HT(1A) receptors on adrenergic neurons to effect norepinephrine release. Norepinephrine 240-254 5-hydroxytryptamine receptor 1A Oryctolagus cuniculus 189-196 30341172-4 2018 Dopamine is converted to norepinephrine by dopamine-beta-hydroxylase (DBH), which acquires its essential Cu cofactor from ATP7A. Norepinephrine 25-39 ATPase copper transporting alpha Homo sapiens 122-127 30619611-1 2019 alpha1A- and alpha1B-adrenoceptors (ARs) are G protein-coupled receptors (GPCRs) that are activated by adrenaline and noradrenaline to modulate smooth muscle contraction in the periphery, and neuronal outputs in the central nervous system (CNS). Norepinephrine 118-131 calcium voltage-gated channel subunit alpha1 A Homo sapiens 0-7 10423355-7 1999 Furthermore, since norepinephrine infusion also increased HO-1 transcript and protein levels, the HO-1 system probably was induced in RHF by the increased interstitial norepinephrine levels known to occur in failing myocardium. Norepinephrine 19-33 heme oxygenase 1 Canis lupus familiaris 58-62 10423355-7 1999 Furthermore, since norepinephrine infusion also increased HO-1 transcript and protein levels, the HO-1 system probably was induced in RHF by the increased interstitial norepinephrine levels known to occur in failing myocardium. Norepinephrine 19-33 heme oxygenase 1 Canis lupus familiaris 98-102 10423355-7 1999 Furthermore, since norepinephrine infusion also increased HO-1 transcript and protein levels, the HO-1 system probably was induced in RHF by the increased interstitial norepinephrine levels known to occur in failing myocardium. Norepinephrine 168-182 heme oxygenase 1 Canis lupus familiaris 98-102 10338466-1 1999 BACKGROUND: Elevated circulating norepinephrine (NE) has been implicated in causing the profound beta-adrenergic receptor (betaAR) downregulation and receptor uncoupling that are characteristic of end-stage human dilated cardiomyopathy, a process mediated in part by increased levels of beta-adrenergic receptor kinase (betaARK1). Norepinephrine 33-47 adrenergic receptor, beta 1 Mus musculus 123-129 10228005-0 1999 Suppression of antigen-specific Th2 cell-dependent IgM and IgG1 production following norepinephrine depletion in vivo. Norepinephrine 85-99 LOC105243590 Mus musculus 59-63 30341696-1 2018 In early 1920s, tyramine oxidase was discovered that metabolized tyramine and in 1933 Blaschko demonstrated that this enzyme also metabolized adrenaline, noradrenaline and dopamine. Norepinephrine 154-167 monoamine oxidase B Homo sapiens 16-32 10200422-2 1999 The release of [3H]-noradrenaline ([3H]-NA) in response to nicotinic acetylcholine receptor (nAChR) agonists was compared with agonist-induced currents in cultured rat superior cervical ganglion (SCG) neurones. Norepinephrine 20-33 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 59-91 30341278-8 2018 Fine-tuning of noradrenaline homeostasis by a MIR579 genetic variation modulated central and peripheral sympathetic noradrenergic activation during fear processing and anxiety. Norepinephrine 15-28 microRNA 579 Homo sapiens 46-52 10067839-9 1999 These findings suggest that histamine induces systemic and intranuclear OT release by stimulating the release of norepinephrine. Norepinephrine 113-127 oxytocin/neurophysin I prepropeptide Homo sapiens 72-74 29851347-6 2018 Here, we briefly discuss the effects of catecholamine receptor modulators on synaptic plasticity in the BNST due to the role of norepinephrine in LTD and dopamine on the short-term component of LTP as well as the role that signaling at these receptors plays in reinstatement of drug- and alcohol-seeking behaviors. Norepinephrine 128-142 adrenoceptor beta 2 Homo sapiens 40-62 29878130-9 2018 Similarly, UCP2 and UCP3 protein levels were increased in differentiated adipocytes upon acute norepinephrine stimulation. Norepinephrine 95-109 uncoupling protein 3 Homo sapiens 20-24 30106035-6 2018 In essence, the literature reviewed herein supports our hypothesis of a tripartite neuroprotective role for noradrenaline in combating PD-related neuropathology and motor dysfunction via (1) inhibiting nigral microglial activation & pro-inflammatory mediator production, (2) promoting the synthesis of neurotrophic factors from midbrain astrocytes and (3) downregulating alpha-synuclein gene expression and protein abundance in a beta2-AR-dependent manner. Norepinephrine 108-121 adrenoceptor beta 2 Homo sapiens 434-442 29496635-8 2018 There was a significant increase in norepinephrine concentration in the SN of Pink1 -/- animals. Norepinephrine 36-50 PTEN induced kinase 1 Rattus norvegicus 78-83 29524394-8 2018 Collectively, these findings provide useful information relevant to the differential metabolism of dopamine, epinephrine, norepinephrine and serotonin through sulfoconjugation in individuals having different SULT1A3/SULT1A4 genotypes. Norepinephrine 122-136 sulfotransferase family 1A member 3 Homo sapiens 208-215 29888233-4 2018 Fez1-knockout (KO) mice show reduced expression of tyrosine hydroxylase in the midbrain and the brain stem and have reduced levels of dopamine, norepinephrine, or their metabolites in both the nucleus accumbens and the prefrontal cortex. Norepinephrine 144-158 fasciculation and elongation protein zeta 1 (zygin I) Mus musculus 0-4 10022442-4 1999 In addition, circulating norepinephrine levels increased by 55 +/- 16% (P < 0.02) 1 h after intracerebroventricular leptin administration, but did not increase after artificial cerebrospinal fluid administration. Norepinephrine 25-39 leptin Macaca mulatta 119-125 9927621-2 1999 In PC12 cells stably transfected with the human alpha-1A AR, norepinephrine (NE) strongly activated both extracellular signal regulated kinases (ERKs) and c-jun-NH2-terminal kinases (JNK). Norepinephrine 61-75 calcium voltage-gated channel subunit alpha1 A Homo sapiens 48-56 10090125-8 1999 Norepinephrine-precontracted urethral rings of male guinea pigs exhibit a relaxation response at 10 Hz that is alpha1-adrenergic, non-cholinergic, non-purinergic, and independent of NPY. Norepinephrine 0-14 pro-neuropeptide Y Cavia porcellus 182-185 10052667-3 1998 The noradrenaline infusion increased the unstimulated, the interleukin-2 and interferon-alpha stimulated NK cell activity, and the percentage of CD16+ cells. Norepinephrine 4-17 Fc gamma receptor IIIa Homo sapiens 145-149 9862381-1 1998 Neuropeptide Y (NPY) is both co-stored and co-released with noradrenaline from sympathetic nerve terminals. Norepinephrine 60-73 neuropeptide Y Canis lupus familiaris 0-14 9862381-1 1998 Neuropeptide Y (NPY) is both co-stored and co-released with noradrenaline from sympathetic nerve terminals. Norepinephrine 60-73 neuropeptide Y Canis lupus familiaris 16-19 9760026-10 1998 Moreover, the results show that, besides its sympatho-inhibitory effect, losartan can exert a sympatho-excitatory action as shown by the increase in the plasma levels of both noradrenaline and its coneurotransmitter, neuropeptide Y. Norepinephrine 175-188 neuropeptide Y Canis lupus familiaris 217-231 9707197-7 1998 The plasma noradrenaline concentration during period 2 was higher in patients with hyponatremia than in those with normonatremia (P < 0.05), whereas the plasma concentrations of ADH and ANP during period 2 were not statistically different between the hyponatremic and normonatremic patients. Norepinephrine 11-24 period circadian regulator 2 Homo sapiens 46-54 28598954-6 2017 RESULTS: Noradrenaline treatment resulted in a pronounced increase in SGLT2 and interleukin (IL)-6 expression in HK2 cells and promoted translocation of SGLT2 to the cell surface. Norepinephrine 9-22 solute carrier family 5 (sodium/glucose cotransporter), member 2 Mus musculus 70-75 28598954-6 2017 RESULTS: Noradrenaline treatment resulted in a pronounced increase in SGLT2 and interleukin (IL)-6 expression in HK2 cells and promoted translocation of SGLT2 to the cell surface. Norepinephrine 9-22 solute carrier family 5 (sodium/glucose cotransporter), member 2 Mus musculus 153-158 28598954-8 2017 SGLT2 inhibition significantly reduced high-fat diet-induced elevations of tyrosine hydroxylase and noradrenaline in the kidney and heart. Norepinephrine 100-113 solute carrier family 5 (sodium/glucose cotransporter), member 2 Mus musculus 0-5 28439935-8 2017 The upregulation of locus ceruleus tyrosine hydroxylase, upregulates norepinephrine in the cerebrospinal fluid that acts on adrenergic receptors to enhance pCREB binding to the cAMP response element, which recruits histone acetylene transferase (HAT) to the BDNF gene to enhance its transcription resulting in aggravated visceromotor response to colorectal distension. Norepinephrine 69-83 brain derived neurotrophic factor Homo sapiens 258-262 28472693-8 2017 In the CRH group, the total increase of sAA activity significantly correlated with noradrenaline release, indicating that sAA activity reflects pharmacologically induced sympathetic activation. Norepinephrine 83-96 amylase alpha 1A Homo sapiens 122-125 28430139-5 2017 In addition, noradrenaline, the major neurotransmitter of the sympathetic nervous system, results in elevated Adam28 mRNA expression in human monocytes. Norepinephrine 13-26 ADAM metallopeptidase domain 28 Homo sapiens 110-116 28100476-10 2017 These findings indicate a functional islet defect in anemic fetuses, which likely involves direct effects of low oxygen and/or increased norepinephrine on insulin release. Norepinephrine 137-151 LOC105613195 Ovis aries 155-162 28232237-1 2017 It has been suggested that central norepinephrine (NE) activity may be inferred from increases in salivary alpha-amylase (SAA), but data in favor of this proposition are limited. Norepinephrine 35-49 amylase alpha 1A Homo sapiens 98-120 28232237-1 2017 It has been suggested that central norepinephrine (NE) activity may be inferred from increases in salivary alpha-amylase (SAA), but data in favor of this proposition are limited. Norepinephrine 35-49 amylase alpha 1A Homo sapiens 122-125 26549422-2 2017 Recent evidence suggests that the norepinephrine system and more specifically the alpha2A -adrenergic receptor (ADRA2A) are impacted by chronic cocaine use while also being potentially involved in the neural mechanisms underlying DD. Norepinephrine 34-48 adrenoceptor alpha 2A Homo sapiens 112-118 26549422-8 2017 As the relationship between DD and cocaine use was moderated by ADRA2A SNPs and by peripheral ADRA2A gene expression, we propose that the norepinephrine system is involved in DD deficits observed in cocaine using individuals. Norepinephrine 138-152 adrenoceptor alpha 2A Homo sapiens 64-70 26549422-8 2017 As the relationship between DD and cocaine use was moderated by ADRA2A SNPs and by peripheral ADRA2A gene expression, we propose that the norepinephrine system is involved in DD deficits observed in cocaine using individuals. Norepinephrine 138-152 adrenoceptor alpha 2A Homo sapiens 94-100 9861628-4 1998 The results indicate that: 1) CCK-33 enhances the influence of catecholamines: noradrenaline and isoprenaline, mainly on the function of isolated heart. Norepinephrine 79-92 cholecystokinin Rattus norvegicus 30-33 27761593-4 2017 We found that activation of CREB-dependent transcription reduced the calcium responses induced by ATP, noradrenaline, or endothelin-1. Norepinephrine 103-116 cAMP responsive element binding protein 1 Homo sapiens 28-32 9605572-5 1998 Adrenomedullin and alpha-CGRP caused a concentration-dependent relaxation in the rat aorta contracted with noradrenaline. Norepinephrine 107-120 adrenomedullin Rattus norvegicus 0-14 27860160-6 2017 CPAP treatment decreased norepinephrine levels while the 24-hour profiles of growth hormone and cortisol remained unchanged. Norepinephrine 25-39 centromere protein J Homo sapiens 0-4 27986860-1 2017 We have previously shown that ONO-2952, a novel 18-kDa translocator protein (TSPO) antagonist, inhibits stress-induced accumulation of neurosteroids and noradrenaline release in the rat brain and alleviates the subsequent symptomatic responses with a brain TSPO occupancy of 50% or more. Norepinephrine 153-166 translocator protein Rattus norvegicus 77-81 27923568-7 2017 Noradrenaline also increased CX3CL1 in its soluble form despite the inhibition of the activity and synthesis of ADAM10 and ADAM17, the main proteases known to cleave CX3CL1 from the neuronal membrane. Norepinephrine 0-13 ADAM metallopeptidase domain 17 Homo sapiens 123-129 27753095-16 2017 Noradrenaline also evoked TRPC1 channel activity and associations between TRPC1, STIM1, Galphaq and PLCbeta1, which were inhibited by STIM1 knockdown. Norepinephrine 0-13 transient receptor potential cation channel subfamily C member 1 Homo sapiens 26-31 9512271-11 1998 The functional role of GAL may be related to noradrenaline, possibly by a presynaptic action. Norepinephrine 45-58 galanin and GMAP prepropeptide Homo sapiens 23-26 27753095-16 2017 Noradrenaline also evoked TRPC1 channel activity and associations between TRPC1, STIM1, Galphaq and PLCbeta1, which were inhibited by STIM1 knockdown. Norepinephrine 0-13 transient receptor potential cation channel subfamily C member 1 Homo sapiens 74-79 27951473-6 2017 In anaesthetized 7-week-old male Sprague-Dawley rats, the OA (3.8 mg of intravenous injection)-induced increase in plasma noradrenaline secretion was suppressed by TRPA1 or TRPV1 antagonist and by a beta2- or beta3-adrenoceptor antagonist. Norepinephrine 122-135 adrenoceptor beta 3 Rattus norvegicus 209-227 28652540-5 2017 Then, we showed that noradrenaline treatment stimulated ghrelin secretion via beta1-adrenergic receptor, and fasting-induced ghrelin elevation was completely inhibited by the beta1-adrenergic receptor antagonist in mice. Norepinephrine 21-34 adrenergic receptor, beta 1 Mus musculus 78-103 9548392-12 1998 These data suggest that endogenous PAF contributes to the vascular hyporeactivity to noradrenaline induced by endotoxin and that NO plays a major role in the endotoxin-induced hyporeactivity. Norepinephrine 85-98 PCNA clamp associated factor Rattus norvegicus 35-38 28652540-5 2017 Then, we showed that noradrenaline treatment stimulated ghrelin secretion via beta1-adrenergic receptor, and fasting-induced ghrelin elevation was completely inhibited by the beta1-adrenergic receptor antagonist in mice. Norepinephrine 21-34 adrenergic receptor, beta 1 Mus musculus 175-200 27512975-7 2016 Similarly, mean plasma noradrenaline was significantly reduced for both light-intensity walking (-0.3 +- 0.1 nmol/l) and SRA (-0.6 +- 0.1 nmol/l) versus SIT, with SRA lower than light-intensity walking (P < 0.05). Norepinephrine 23-36 steroid receptor RNA activator 1 Homo sapiens 121-124 9474095-8 1998 After precontraction with norepinephrine, the maximal relaxation to acetylcholine (endothelium-dependent, receptor-mediated agonist) for control vein grafts was 0%, whereas for VEGF-treated vein grafts it was 25% +/- 9% (p < 0.05 vs control grafts). Norepinephrine 26-40 vascular endothelial growth factor A Oryctolagus cuniculus 177-181 9825471-2 1998 For the first time discovered universal action of diets with PUFA omega-3 vegetable and animal origin on parameters of humoral immunity: in case of primary excess of norm of the contents of natural antibodies to adrenaline, noradrenaline and dopamine as a result of treatment these parameters were reduced or did not change; and at is primary a low their level--parameters increased in most cases. Norepinephrine 224-237 pumilio RNA binding family member 3 Homo sapiens 61-65 27512975-7 2016 Similarly, mean plasma noradrenaline was significantly reduced for both light-intensity walking (-0.3 +- 0.1 nmol/l) and SRA (-0.6 +- 0.1 nmol/l) versus SIT, with SRA lower than light-intensity walking (P < 0.05). Norepinephrine 23-36 steroid receptor RNA activator 1 Homo sapiens 163-166 27512975-9 2016 CONCLUSION: Interrupting prolonged sitting with brief bouts of light-intensity walking or SRA reduces resting BP and plasma noradrenaline in adults with T2D, with SRA being more effective. Norepinephrine 124-137 steroid receptor RNA activator 1 Homo sapiens 90-93 27059884-8 2016 Norepinephrine (noradrenaline) released at the distal end of the splenic nerve links to the beta2 adrenergic receptor of splenic lymphocytes that release ACh. Norepinephrine 0-14 adrenoceptor beta 2 Homo sapiens 92-117 11938962-2 1998 The results indicate that NGF dose-dependently increased norepinephrine content in mouse submandibular gland and cell numbers of C7 (seventh cervical vertebra), T1 (first thoracic vertebra) dorsal root ganglion in rabbits, and also dramatically promoted the growth of neuronal projections in cultured DRG. Norepinephrine 57-71 nerve growth factor Mus musculus 26-29 9405459-8 1997 Since a subpressor dose of Ang II did not increase GRK5 mRNA levels and norepinephrine infusion also increased GRK5 mRNA expression, we conclude that Ang II-induced GRK5 up-regulation in rat aortas may be due to hypertension per se. Norepinephrine 72-86 G protein-coupled receptor kinase 5 Rattus norvegicus 111-115 9405459-8 1997 Since a subpressor dose of Ang II did not increase GRK5 mRNA levels and norepinephrine infusion also increased GRK5 mRNA expression, we conclude that Ang II-induced GRK5 up-regulation in rat aortas may be due to hypertension per se. Norepinephrine 72-86 G protein-coupled receptor kinase 5 Rattus norvegicus 111-115 27059884-8 2016 Norepinephrine (noradrenaline) released at the distal end of the splenic nerve links to the beta2 adrenergic receptor of splenic lymphocytes that release ACh. Norepinephrine 16-29 adrenoceptor beta 2 Homo sapiens 92-117 9395518-7 1997 The magnitude of Cig30 mRNA induction in the cold could be mimicked by chronic norepinephrine treatment in vivo. Norepinephrine 79-93 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 Mus musculus 17-22 9395518-8 1997 However, in primary cultures of brown adipocytes, a synergistic action of norepinephrine and dexamethasone was required for full expression of the gene, indicating that both catecholamines and glucocorticoids are required for the induction of Cig30. Norepinephrine 74-88 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 Mus musculus 243-248 27320040-4 2016 Using multiple hPSC reporter lines, we recapitulated human autonomic neuron development in vitro and successfully isolated PHOX2B::eGFP+ neurons that exhibit sympathetic marker expression and electrophysiological properties and norepinephrine secretion. Norepinephrine 228-242 paired like homeobox 2B Homo sapiens 123-129 9436100-5 1997 Elevated norepinephrine concentrations during the pretreatment period were associated with the inhibition of oxytocin responses. Norepinephrine 9-23 oxytocin/neurophysin I prepropeptide Homo sapiens 109-117 9436100-6 1997 When norepinephrine concentrations during the pretreatment period exceeded 300 pg/ml for Friescens, or were rising and exceeded 700 pg/ml at initiation of the experimental period for Lacaunes, oxytocin release was inhibited. Norepinephrine 5-19 oxytocin/neurophysin I prepropeptide Homo sapiens 193-201 9428976-8 1997 The inhibition of K+ (IC50 0.5 mumol/l)- and noradrenaline (IC50 1.3 mumol/l)-induced contractions of rabbit aorta rings was in the same concentration range as found for the calmodulin inhibitory activity. Norepinephrine 45-58 calmodulin Oryctolagus cuniculus 174-184 9449068-13 1997 Neurotrophin-3 (NT-3) specifically promotes high affinity uptake of norepinephrine by neural crest cells and is thus thought to play a critical role in the differentiation of sympathetic neuroblasts. Norepinephrine 68-82 neurotrophin 3 Homo sapiens 0-14 9428617-11 1997 Combination of norepinephrine with pre- and afterload elevation induced the c-fos mRNA signal to appear earlier, to be more pronounced, and to persist for a longer period of time. Norepinephrine 15-29 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 76-81 9387858-1 1997 The principal brain vesicular monoamine transporter (VMAT2) pumps monoamines including dopamine, norepinephrine, serotonin and histamine from neuronal cytoplasm into synaptic vesicles and is implicated in actions of certain psychostimulants and selective neurotoxins. Norepinephrine 97-111 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 53-58 9251973-3 1997 Noradrenaline, clonidine (an alpha2-adrenergic receptor agonist), or phenylephrine (an alpha1-adrenergic receptor agonist) injected into the MnPO of sham-lesioned rats reduced water ingestion induced by ANG II injected into the same area. Norepinephrine 0-13 angiogenin Rattus norvegicus 203-206 9432289-4 1997 The inhibition of MAO-A cause the rise of norepinephrine, dopamine and serotonin in the synaptic cleft, of MAO-B only of dopamine. Norepinephrine 42-56 monoamine oxidase B Homo sapiens 107-112 27106352-11 2016 CONCLUSIONS: The expression of the alpha2-AR subtypes is sensitive to 17beta-estradiol, which decreases the contractile response of (-)-noradrenaline via the alpha2B-AR subtype, and might cause changes in G-protein signaling pathway. Norepinephrine 132-149 adrenoceptor alpha 2B Rattus norvegicus 158-168 27305421-10 2016 In the probabilistic sensitivity analysis, it was verified that the cost of the treatment with noradrenaline could vary between Int$2,326.53 and Int$3,644.16, while costs related to the treatment using terlipressin are not variable. Norepinephrine 95-108 notch receptor 4 Homo sapiens 145-150 26843180-11 2016 The potency of norepinephrine for adrenergic alpha2A receptor was only about 20-fold higher compared with D3R and D4R across the three functional assays. Norepinephrine 15-29 adrenoceptor alpha 2A Homo sapiens 34-61 26741414-17 2016 Norepinephrine augments loss of neurons in CA1 and CA3 hippocampus of male piglets after fluid percussion injury in an extracellular signal-regulated kinase mitogen-activated protein kinase-dependent and interleukin-6-dependent manner but prevents loss of neurons in females after fluid percussion injury. Norepinephrine 0-14 carbonic anhydrase 1 Homo sapiens 43-46 27356717-2 2016 In BCa, several studies have linked beta2-adrenergic receptor activation with increased tumour growth and progression as related with Epinephrine-NorEpinephrine (E-NE) stimulation. Norepinephrine 146-160 adrenoceptor beta 2 Homo sapiens 36-61 9154329-13 1997 In cross-loading experiments, 5 mM Na(+)- or 0 Cl(-)-induced efflux was much lower from [3H]-noradrenaline-loaded DAT, than NAT cells and was sensitive to mazindol, but not to desipramine. Norepinephrine 93-106 solute carrier family 6 member 3 Homo sapiens 114-117 26277325-0 2015 Reduction in renal blood flow following administration of norepinephrine and phenylephrine in septic rats treated with Kir6.1 ATP-sensitive and KCa1.1 calcium-activated K+ channel blockers. Norepinephrine 58-72 potassium inwardly-rectifying channel, subfamily J, member 8 Rattus norvegicus 119-125 9039140-14 1997 The afferent arteriolar response to norepinephrine was enhanced in renal-denervated, Ang II-infused, and Ang II-infused+renal-denervated rats compared with sham controls. Norepinephrine 36-50 angiogenin Rattus norvegicus 85-88 25921770-13 2015 Thus, the CB1 receptor-mediated inhibition of noradrenaline release from the sympathetic nerve fibres innervating the resistance vessels might play a protective role in hypertension. Norepinephrine 46-59 cannabinoid receptor 1 Rattus norvegicus 10-13 26203906-0 2015 Norepinephrine-Induced Adrenergic Activation Strikingly Increased the Atrial Fibrillation Duration through beta1- and alpha1-Adrenergic Receptor-Mediated Signaling in Mice. Norepinephrine 0-14 adrenergic receptor, beta 1 Mus musculus 107-144 25818584-9 2015 Norepinephrine also decreased mRNA expression of osterix, collagen I, and osteocalcin by mesenchymal stem cells at 7 and 14 d of stimulation and increased the expression of RANKL and RANKL/OPG ratio by mesenchymal stem cells at 2 h. In conclusion, CIS and UAC synergistically promote condylar subchondral bone loss and cartilage degradation; such processes are partially regulated by norepinephrine within subchondral bone. Norepinephrine 0-14 Sp7 transcription factor 7 Mus musculus 49-56 25818584-9 2015 Norepinephrine also decreased mRNA expression of osterix, collagen I, and osteocalcin by mesenchymal stem cells at 7 and 14 d of stimulation and increased the expression of RANKL and RANKL/OPG ratio by mesenchymal stem cells at 2 h. In conclusion, CIS and UAC synergistically promote condylar subchondral bone loss and cartilage degradation; such processes are partially regulated by norepinephrine within subchondral bone. Norepinephrine 0-14 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 189-192 25653192-0 2015 Norepinephrine preferentially modulates memory CD8 T cell function inducing inflammatory cytokine production and reducing proliferation in response to activation. Norepinephrine 0-14 CD8a molecule Homo sapiens 47-50 9437706-1 1997 We have previously reported that atrial natriuretic factor (ANF) modulates adrenomedullar norepinephrine (NE) metabolism. Norepinephrine 90-104 natriuretic peptide A Rattus norvegicus 33-58 9437706-1 1997 We have previously reported that atrial natriuretic factor (ANF) modulates adrenomedullar norepinephrine (NE) metabolism. Norepinephrine 90-104 natriuretic peptide A Rattus norvegicus 60-63 25793511-10 2015 Central GLP-1R activation also increased NTS expression of dopamine-beta-hydroxylase, a key enzyme in noradrenaline synthesis, indicating a biological link between these two systems. Norepinephrine 102-115 glucagon-like peptide 1 receptor Rattus norvegicus 8-14 25561369-5 2015 RESULTS: Adrenaline(A), noradrenaline and the beta-AR agonist isoprenaline reduced N-formyl-Met-Leu-Phe (fMLP)-induced migration, CD11b/CD18 expression, and ROS production, without affecting IL-8. Norepinephrine 24-37 integrin subunit alpha M Homo sapiens 130-135 24647754-7 2015 Monoamine quantification and gene expression profiling demonstrated a specific enrichment of noradrenaline only in the superficial layers of the superior colliculus of Isl2-EphA3 knock-in mice, where the retinotopy is duplicated, whereas transcript levels of receptors, transporters and metabolic enzymes of the monoaminergic pathway were not affected. Norepinephrine 93-106 insulin related protein 2 (islet 2) Mus musculus 168-172 25359531-9 2015 Noradrenaline in the CeA was increased by CRD, further increased by CRH, and inhibited by CRH-R1 antagonist. Norepinephrine 0-13 corticotropin releasing hormone receptor 1 Rattus norvegicus 90-96 25402186-4 2014 In the present study, using immunodetection methods, we revealed the presence of several proteins important for the dopamine uptake and signalling in mammalian sperm, specifically monoamine transporters as dopamine (DAT), serotonin (SERT) and norepinephrine (NET) transporters in equine sperm. Norepinephrine 243-257 solute carrier family 6 member 3 Homo sapiens 216-219 8952593-8 1996 Atrial natriuretic factor, however, increased at 7 and 14 days of servo-controlled norepinephrine, and plasma renin activity increased on day 14 of norepinephrine infusion. Norepinephrine 148-162 renin Canis lupus familiaris 110-115 25179535-7 2014 Inhibitors of beta2-adrenergic receptor (beta2-AR), protein kinase A (PKA), and mTOR could reverse norepinephrine-induced Jagged 1 upregulation, indicating that the beta2-AR-PKA-mTOR pathway participates in this process. Norepinephrine 99-113 adrenoceptor beta 2 Homo sapiens 14-39 25179535-7 2014 Inhibitors of beta2-adrenergic receptor (beta2-AR), protein kinase A (PKA), and mTOR could reverse norepinephrine-induced Jagged 1 upregulation, indicating that the beta2-AR-PKA-mTOR pathway participates in this process. Norepinephrine 99-113 adrenoceptor beta 2 Homo sapiens 41-49 25179535-7 2014 Inhibitors of beta2-adrenergic receptor (beta2-AR), protein kinase A (PKA), and mTOR could reverse norepinephrine-induced Jagged 1 upregulation, indicating that the beta2-AR-PKA-mTOR pathway participates in this process. Norepinephrine 99-113 adrenoceptor beta 2 Homo sapiens 165-173 25179535-9 2014 These data demonstrate that tumor angiogenesis mediated by the Jagged 1/Notch intercellular signaling is governed by the norepinephrine-activated beta2-AR-PKA-mTOR pathway. Norepinephrine 121-135 adrenoceptor beta 2 Homo sapiens 146-154 25229819-8 2014 However, conditioned media from astrocytes exposed to norepinephrine or isoproterenol (a beta adrenergic agonist) significantly increased neurite outgrowth when applied to neuronal cultures. Norepinephrine 54-68 amyloid beta precursor protein Rattus norvegicus 87-93 25050919-7 2014 Importantly, pro-hypertrophic signalling pathways such as those driven by angiotensin II and norepinephrine also regulate miR-23a-miR-27a-miR-24-2 cluster proximal promoter activity. Norepinephrine 93-107 microRNA 23a Homo sapiens 122-129 24837703-11 2014 Consistently, in the presence of propranolol (10(-6)M), a beta-AR blocker, the arterenol (10(-8)M) effects on thymocytes were augmented. Norepinephrine 79-88 adrenoceptor beta 2 Homo sapiens 63-65 24796498-4 2014 Vasodilation induced by G-1 (selective GPER-agonist, 3 muM) from HRAs pre-contracted with norepinephrine amounted to 40+-5% in PMW, significantly larger than those obtained from M (20+-5%) or PGW (20+-5%). Norepinephrine 90-104 G protein-coupled estrogen receptor 1 Homo sapiens 39-43 24497580-5 2014 Analysis of germline VGF-knockout mouse adrenal medulla revealed decreased LDCV size in noradrenergic chromaffin cells, increased adrenal norepinephrine and epinephrine content and circulating plasma epinephrine, and decreased adrenal CgB. Norepinephrine 138-152 VGF nerve growth factor inducible Mus musculus 21-24 24431221-3 2014 The sympathetic neurotransmitter Norepinephrine (NE) induced complete and rapid mitochondrial fragmentation in BA, characterized by Drp1 phosphorylation and Opa1 cleavage. Norepinephrine 33-47 OPA1, mitochondrial dynamin like GTPase Mus musculus 157-161 24138638-2 2014 Activation of brain CB1 receptors inhibited the secretion of adrenal catecholamines (noradrenaline and adrenaline) induced by i.c.v. Norepinephrine 85-98 cannabinoid receptor 1 Rattus norvegicus 20-23 9035611-14 1996 Norepinephrine induced translocation of PKC-alpha, -beta I, -beta II, -gamma, -delta, and -epsilon isoforms but not -zeta and -eta from cytosol to membrane. Norepinephrine 0-14 protein kinase C, alpha Rattus norvegicus 40-49 8939965-0 1996 Calcium/calmodulin-dependent protein kinase IIalpha mediates activation of mitogen-activated protein kinase and cytosolic phospholipase A2 in norepinephrine-induced arachidonic acid release in rabbit aortic smooth muscle cells. Norepinephrine 142-156 cytosolic phospholipase A2 Oryctolagus cuniculus 112-138 8903325-8 1996 These data support the hypothesis that local ANP inhibits noradrenaline release in the AHA and thereby contributes to NaCl-sensitive hypertension in SHR. Norepinephrine 58-71 natriuretic peptide A Rattus norvegicus 45-48 8911658-4 1996 In ovariectomised oil-treated rats, a third ventricular infusion of noradrenaline (45 micrograms) resulted in a significant (P < 0.05) increase in the numbers of Fos-immunoreactive cell nuclei throughout the preoptic area, compared to vehicle controls. Norepinephrine 68-81 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 165-168 8911658-9 1996 These results show that noradrenaline-induced Fos expression in the preoptic area is dependent on estrogen status and suggest that the estrogenic regulation of reproductive functions may thus involve altered responses to noradrenaline in sub-populations of preoptic neurones. Norepinephrine 24-37 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 46-49 24297249-1 2014 We found previously that stimulation of natriuretic peptide receptor (NPR)-B by C-type natriuretic peptide (CNP) in failing rat ventricle potentiates beta1-adrenoceptor (beta1-AR)-mediated inotropic response to noradrenaline through cGMP-mediated inhibition of phosphodiesterase (PDE) 3, thereby enhancing cAMP-mediated signalling. Norepinephrine 211-224 natriuretic peptide C Rattus norvegicus 80-106 24297249-1 2014 We found previously that stimulation of natriuretic peptide receptor (NPR)-B by C-type natriuretic peptide (CNP) in failing rat ventricle potentiates beta1-adrenoceptor (beta1-AR)-mediated inotropic response to noradrenaline through cGMP-mediated inhibition of phosphodiesterase (PDE) 3, thereby enhancing cAMP-mediated signalling. Norepinephrine 211-224 natriuretic peptide C Rattus norvegicus 108-111 24297249-9 2014 We identified several small molecule NPR-B antagonists by high throughput screening and show in a functional heart preparation that blocking NPR-B stimulation with a small molecule compound can reduce the potentiating effect of CNP on the beta1-AR-mediated inotropic response to noradrenaline. Norepinephrine 279-292 natriuretic peptide C Rattus norvegicus 228-231 24025942-11 2014 The coordinate loss of dopamine and norepinephrine neurons in VMAT2 LO mice parallels the pattern of neurodegeneration that occurs in human PD, and demonstrates that insufficient catecholamine storage can cause spontaneous degeneration in susceptible neurons, underscoring cytosolic catecholamine catabolism as a determinant of neuronal susceptibility in PD. Norepinephrine 36-50 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 62-67 8902882-5 1996 Norepinephrine and epinephrine also suppressed IL-12 production in a dose-dependent fashion and at physiological concentrations; both catecholamines, however, dose-dependently increased the production of IL-10. Norepinephrine 0-14 interleukin 10 Homo sapiens 204-209 23810893-10 2013 Importantly, PDE2-overexpressing cardiomyocytes showed marked protection from norepinephrine-induced hypertrophic responses. Norepinephrine 78-92 phosphodiesterase 2A Rattus norvegicus 13-17 23489141-4 2013 The effects of (-)-noradrenaline, mediated through beta1 adrenoceptors (beta2 adrenoceptors blocked with ICI118551), and (-)-adrenaline, mediated through beta2 adrenoceptors (beta1 adrenoceptors blocked with CGP20712A), were assessed in the absence and presence of PDE inhibitors. Norepinephrine 15-32 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 175-180 23105094-8 2012 Interestingly, the Ser-364 allele (detected in ~15% subjects) was strongly associated with profound reduction (up to ~2.1-fold) in plasma norepinephrine/epinephrine levels consistent with the diminished nAChR desensitization-blocking effect of CST-Ser-364 as compared with CST-WT. Norepinephrine 138-152 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 203-208 23190744-10 2012 Patients with elevated cTnI more frequently required vasopressors-norepinephrine (73% vs 50%, P = 0.008). Norepinephrine 66-80 troponin I3, cardiac type Homo sapiens 23-27 22441984-3 2012 The present study tests the hypothesis that increased norepinephrine causes epigenetic repression of PKCepsilon gene in the heart via Nox1-dependent reactive oxygen species (ROS) production. Norepinephrine 54-68 NADPH oxidase 1 Rattus norvegicus 134-138 22890201-2 2012 Both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) regulate neurochemistry by degrading monoamine neurotransmitters (serotonin, dopamine, and norepinephrine). Norepinephrine 156-170 monoamine oxidase B Homo sapiens 37-56 22890201-2 2012 Both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) regulate neurochemistry by degrading monoamine neurotransmitters (serotonin, dopamine, and norepinephrine). Norepinephrine 156-170 monoamine oxidase B Homo sapiens 58-63 22579288-3 2012 BMP8B is induced by nutritional and thermogenic factors in mature BAT, increasing the response to noradrenaline through enhanced p38MAPK/CREB signaling and increased lipase activity. Norepinephrine 98-111 bone morphogenetic protein 8b Mus musculus 0-5 21702050-4 2012 Our data are as follows: (a) The calcineurin inhibitor cyclosporine A (CsA) blocked norepinephrine secretion induced by ligands of either CRF type 1 (CRF(1)) or 2 (CRF(2)) receptors on PC12 cells. Norepinephrine 84-98 corticotropin releasing hormone receptor 1 Rattus norvegicus 138-148 21702050-4 2012 Our data are as follows: (a) The calcineurin inhibitor cyclosporine A (CsA) blocked norepinephrine secretion induced by ligands of either CRF type 1 (CRF(1)) or 2 (CRF(2)) receptors on PC12 cells. Norepinephrine 84-98 corticotropin releasing hormone receptor 1 Rattus norvegicus 150-156 21702050-4 2012 Our data are as follows: (a) The calcineurin inhibitor cyclosporine A (CsA) blocked norepinephrine secretion induced by ligands of either CRF type 1 (CRF(1)) or 2 (CRF(2)) receptors on PC12 cells. Norepinephrine 84-98 corticotropin releasing hormone receptor 2 Rattus norvegicus 164-169 21702050-10 2012 (f) p38-MAPK and Tpl2 were crucial intermediates for both CRF(1) and CRF(2)-induced norepinephrine production, while AKT1 affected only CRF(2)-induced norepinephrine production. Norepinephrine 84-98 mitogen-activated protein kinase kinase kinase 8 Rattus norvegicus 17-21 21702050-10 2012 (f) p38-MAPK and Tpl2 were crucial intermediates for both CRF(1) and CRF(2)-induced norepinephrine production, while AKT1 affected only CRF(2)-induced norepinephrine production. Norepinephrine 84-98 corticotropin releasing hormone receptor 1 Rattus norvegicus 58-64 21702050-10 2012 (f) p38-MAPK and Tpl2 were crucial intermediates for both CRF(1) and CRF(2)-induced norepinephrine production, while AKT1 affected only CRF(2)-induced norepinephrine production. Norepinephrine 84-98 corticotropin releasing hormone receptor 2 Rattus norvegicus 69-74 21702050-10 2012 (f) p38-MAPK and Tpl2 were crucial intermediates for both CRF(1) and CRF(2)-induced norepinephrine production, while AKT1 affected only CRF(2)-induced norepinephrine production. Norepinephrine 151-165 corticotropin releasing hormone receptor 2 Rattus norvegicus 69-74 21702050-10 2012 (f) p38-MAPK and Tpl2 were crucial intermediates for both CRF(1) and CRF(2)-induced norepinephrine production, while AKT1 affected only CRF(2)-induced norepinephrine production. Norepinephrine 151-165 corticotropin releasing hormone receptor 2 Rattus norvegicus 136-141 22405824-0 2012 Desipramine selectively potentiates norepinephrine-elicited ERK1/2 activation through the alpha2A adrenergic receptor. Norepinephrine 36-50 adrenoceptor alpha 2A Homo sapiens 90-117 21855626-3 2012 We have also learned that engagement of the beta(2)AR on lymphocytes, by either norepinephrine or a selective pharmacologic ligand, regulates the level of lymphocyte activity differentially, depending on the time of receptor engagement in relation to the activation and differentiation state of the cell, the molecular signaling pathway activated, and the cytokine microenvironment. Norepinephrine 80-94 adrenoceptor beta 2 Homo sapiens 44-53 22916250-15 2012 CONCLUSIONS: Beta-adrenergic receptor-1 mediates liver norepinephrine modulation of the pro-inflammatory response in CCl(4)-treated mice with bacterial-DNA. Norepinephrine 55-69 chemokine (C-C motif) ligand 4 Mus musculus 117-123 21900458-5 2011 TAL NaCl reabsorption is subject to exquisite control by hormones like vasopressin, parathyroid, glucagon, and adrenergic agonists (epinephrine and norepinephrine) that stimulate NaCl reabsorption. Norepinephrine 148-162 transaldolase 1 Homo sapiens 0-3 21237150-2 2011 administered (+-)-epibatidine (a non-selective agonist of nicotinic acetylcholine receptors) elevates plasma noradrenaline and adrenaline through brain nicotinic acetylcholine receptor-mediated mechanisms in rats. Norepinephrine 109-122 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 58-90 21361697-3 2011 In order to study the lateral diffusion of beta(2)-adrenergic receptors (beta(2)AR) complexed with fluorescently labeled noradrenaline (Alexa-NA) in plasma membranes of A549 cells, trajectories of single receptor-ligand complexes were monitored using single-particle tracking. Norepinephrine 121-134 adrenoceptor beta 2 Homo sapiens 43-71 21361697-3 2011 In order to study the lateral diffusion of beta(2)-adrenergic receptors (beta(2)AR) complexed with fluorescently labeled noradrenaline (Alexa-NA) in plasma membranes of A549 cells, trajectories of single receptor-ligand complexes were monitored using single-particle tracking. Norepinephrine 121-134 adrenoceptor beta 2 Homo sapiens 73-82 22076148-6 2011 In vivo, chronic treatment with the non-selective antidepressant imipramine as well as the norepinephrine-selective reuptake inhibitor desipramine or the serotonin-selective reuptake inhibitor fluoxetine all decrease p21 expression, and this was associated with increased neurogenesis. Norepinephrine 91-105 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 217-220 20926777-0 2010 Identification and functional implication of a Rho kinase-dependent moesin-EBP50 interaction in noradrenaline-stimulated artery. Norepinephrine 96-109 moesin Rattus norvegicus 68-74 20679667-5 2010 Affected males in this family showed an inherited hemizygous deletion restricted to NDP and two immediately telomeric genes, monoamine oxidase-B (MAO-B) and monoamine oxidase-A (MAO-A), which encode closely related enzymes that metabolize biogenic amines including serotonin, dopamine, and norepinephrine. Norepinephrine 290-304 monoamine oxidase B Homo sapiens 125-144 20679667-5 2010 Affected males in this family showed an inherited hemizygous deletion restricted to NDP and two immediately telomeric genes, monoamine oxidase-B (MAO-B) and monoamine oxidase-A (MAO-A), which encode closely related enzymes that metabolize biogenic amines including serotonin, dopamine, and norepinephrine. Norepinephrine 290-304 monoamine oxidase B Homo sapiens 146-151 20728435-5 2010 A small number of HSD2 immunoreactive neurons was also labeled for dopamine-beta-hydroxylase (DBH), an enzyme involved in norepinephrine biosynthesis. Norepinephrine 122-136 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 18-22 20485326-1 2010 Monoamine oxidases (MAO-A and MAO-B) have a key role in the degradation of amine neurotransmitters, such as dopamine, norepinephrine and serotonin. Norepinephrine 118-132 monoamine oxidase B Homo sapiens 30-35 23051576-4 2010 I present a case report of PLP showing good response to Milnacipran - a novel antidepressant (SNRI) with dual mechanism of action through serotonin and norepinephrine reuptake inhibition similar to TCAs. Norepinephrine 152-166 proteolipid protein 1 Homo sapiens 27-30 20584925-4 2010 Since neurotransmitter deficiencies are thought to underlie depression, we examined neurotransmitter levels in Cplx2-/- mice and found a significant decrease in levels of noradrenaline and the serotonin metabolite 5-hydroxyindoleacetic acid in the hippocampus. Norepinephrine 171-184 complexin 2 Mus musculus 111-116 20810904-6 2010 Norepinephrine and isoproterenol upregulated the expression of Abeta receptor mFPR2, a mouse homolog of human formyl peptide receptor FPR2, through activation of beta(2)AR in microglia. Norepinephrine 0-14 formyl peptide receptor 2 Mus musculus 78-83 20810904-6 2010 Norepinephrine and isoproterenol upregulated the expression of Abeta receptor mFPR2, a mouse homolog of human formyl peptide receptor FPR2, through activation of beta(2)AR in microglia. Norepinephrine 0-14 adrenoceptor beta 2 Homo sapiens 162-171 20810904-7 2010 Norepinephrine also induced mFPR2 expression in mouse brain. Norepinephrine 0-14 formyl peptide receptor 2 Mus musculus 28-33 20808911-1 2010 BACKGROUND: Catechol-O-methyltransferase (COMT) is a key enzyme responsible for the degradation of dopamine and norepinephrine. Norepinephrine 112-126 catechol-O-methyltransferase Mus musculus 12-40 20808911-1 2010 BACKGROUND: Catechol-O-methyltransferase (COMT) is a key enzyme responsible for the degradation of dopamine and norepinephrine. Norepinephrine 112-126 catechol-O-methyltransferase Mus musculus 42-46 20554931-4 2010 In addition to a critical role in intranuclear oxytocin release during lactation, norepinephrine has also been shown to stimulate central oxytocin during gestation. Norepinephrine 82-96 oxytocin/neurophysin I prepropeptide Homo sapiens 138-146 20406628-0 2010 Combined treatment with MAO-A inhibitor and MAO-B inhibitor increases extracellular noradrenaline levels more than MAO-A inhibitor alone through increases in beta-phenylethylamine. Norepinephrine 84-97 monoamine oxidase B Rattus norvegicus 44-49 20406628-11 2010 Our results suggest that the combined treatment with a MAO-A inhibitor and a MAO-B inhibitor strengthens antidepressant effects because the combined treatment increases extracellular noradrenaline levels more than a MAO-A inhibitor alone through increases in beta-phenylethylamine. Norepinephrine 183-196 monoamine oxidase B Rattus norvegicus 77-82 20361987-0 2010 Noradrenaline acting at beta-adrenoceptors induces expression of IL-1beta and its negative regulators IL-1ra and IL-1RII, and drives an overall anti-inflammatory phenotype in rat cortex. Norepinephrine 0-13 interleukin 1 receptor antagonist Rattus norvegicus 102-108 20331606-1 2010 BACKGROUND AND PURPOSE: The present study tested the hypothesis that selective caspase-3 (C-3) knock-out would regulate the contractile actions of noradrenaline (NA) in the dysfunction of adult rat ventricular myocytes (ARVMs) induced by sepsis. Norepinephrine 147-160 complement C3 Rattus norvegicus 79-93 20147605-6 2010 The stimulation of chloride transport by norepinephrine was mediated entirely by its beta-adrenergic effect; however, both the beta- and alpha-adrenergic agonists isoproterenol and phenylephrine prevent the ANG II-mediated inhibition in chloride transport. Norepinephrine 41-55 angiogenin Rattus norvegicus 207-210 20094056-10 2010 AM and nicardipine similarly stimulated plasma noradrenaline and renin activity. Norepinephrine 47-60 adrenomedullin Homo sapiens 0-2 20061033-0 2010 Noradrenaline reuptake inhibitors inhibit expression of chemokines IP-10 and RANTES and cell adhesion molecules VCAM-1 and ICAM-1 in the CNS following a systemic inflammatory challenge. Norepinephrine 0-13 C-C motif chemokine ligand 5 Rattus norvegicus 77-83 20061033-0 2010 Noradrenaline reuptake inhibitors inhibit expression of chemokines IP-10 and RANTES and cell adhesion molecules VCAM-1 and ICAM-1 in the CNS following a systemic inflammatory challenge. Norepinephrine 0-13 intercellular adhesion molecule 1 Rattus norvegicus 123-129 20537159-4 2010 RESULTS: The changes in CIpc accurately tracked the changes in CItd induced by volume expansion (bias, -0.20 +/- 0.63 L/min/m2) as well as by norepinephrine (bias, -0.05 +/- 0.74 L/min/m2). Norepinephrine 142-156 CLOCK interacting pacemaker Homo sapiens 24-28 20537159-5 2010 The changes in CIpc accurately detected an increase in CItd >or= 15% induced by volume expansion and norepinephrine introduction/increase (area under ROC curves, 0.878 (0.736 to 0.960) and 0.924 (0.795 to 0.983), respectively; P < 0.05 versus 0.500 for both). Norepinephrine 104-118 CLOCK interacting pacemaker Homo sapiens 15-19 20537159-8 2010 CONCLUSIONS: The CIpc was reliable and accurate for assessing the CI changes induced by volume expansion and norepinephrine. Norepinephrine 109-123 CLOCK interacting pacemaker Homo sapiens 17-21 19502771-8 2009 Moreover, norepinephrine levels were inversely correlated (r=-0.591; p<0.001) with IFN-gamma expression, a typical Th1 cytokine. Norepinephrine 10-24 negative elongation factor complex member C/D Homo sapiens 118-121 19502644-6 2009 Consistent with increased fatty acid utilization, brown adipocytes cultured from Pctp(-/-) mice exhibited higher oxygen consumption rates in response to norepinephrine. Norepinephrine 153-167 phosphatidylcholine transfer protein Mus musculus 81-85 19643099-4 2009 NOX-1 induced a relaxation of vascular smooth muscles in both endothelium intact and denuded rat aortic rings precontracted with norepinephrine or phenylephrine or KCl. Norepinephrine 129-143 NADPH oxidase 1 Rattus norvegicus 0-5 19643099-5 2009 NOX-1 also significantly antagonized cumulative dose-response effect of norepinephrine, phenylephrine, KCl or calcium with reduction in submaximal contractions. Norepinephrine 72-86 NADPH oxidase 1 Rattus norvegicus 0-5 19695215-10 2009 These findings indicate that norepinephrine stimulates DNA synthesis via alpha1-adrenergic receptors and downstream Ca(2+)/PKC and ERK1/2 activation in rBMSCs. Norepinephrine 29-43 protein kinase C, gamma Rattus norvegicus 123-126 19596829-11 2009 However, rats in the AHF+PP36 group demonstrated a 60% decrease in cardiac endothelial nitric oxide synthase (eNOS) protein expression, and a 56% reduction of myocardial norepinephrine release, when compared with the AHF group"s animals. Norepinephrine 170-184 linker for activation of T cells Rattus norvegicus 25-29 19413597-0 2009 p38 mitogen-activated protein kinase (MAPK) is activated by noradrenaline and serves a cardioprotective role, whereas adrenaline induces p38 MAPK dephosphorylation. Norepinephrine 60-73 adapter molecule crk Gallus gallus 0-3 19413597-2 2009 The aim of the present study was to investigate the role of p38 mitogen-activated protein kinases (MAPK) in mediating the effect of noradrenaline (NA) on cardiomyocyte cell viability. Norepinephrine 132-145 adapter molecule crk Gallus gallus 60-63 19457096-4 2009 Interestingly, HIF-2alpha depleted MAH cells showed dramatically lower (5-12 times) levels of dopamine and noradrenaline compared with wild-type and scrambled controls, even in normoxia (21% O(2)). Norepinephrine 107-120 endothelial PAS domain protein 1 Rattus norvegicus 15-25 19393628-4 2009 In endothelium-intact rat aorta, pretreatment with visfatin (100 ng/ml, 30 min) inhibited noradrenaline (NA; 1 nM-1 microM)-induced contraction. Norepinephrine 90-103 nicotinamide phosphoribosyltransferase Rattus norvegicus 51-59 19463744-8 2009 In the mesenteric arterial segments pre-contracted with norepinephrine (0.001-10 microM), the maximal relaxation rate induced by acetylcholine (10 microM) in UCN-treated group (about 93.3%) was higher than that in SHR control group (about 40.0%) (n=6, P<0.01). Norepinephrine 56-70 urocortin Rattus norvegicus 158-161 19152834-10 2009 They further suggest that the inhibitory effect of noradrenaline on PS may be due to the A1/C1, A2 and to a lesser degree to A5 neurons but not from those of the LC as previously hypothesized. Norepinephrine 51-64 UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus 89-98 18923403-1 2009 The antidepressant desipramine inhibits the reuptake of norepinephrine (NE), leading to activation of both pre- and postsynaptic adrenergic receptors, including alpha-1, alpha-2, beta-1, and beta-2 subtypes. Norepinephrine 56-70 hemoglobin, beta adult minor chain Mus musculus 191-197 19059194-4 2009 Noradrenaline and the selective beta2-adrenoceptor agonists isoprenaline and salmeterol stimulated osteoclast formation and bone resorption in BM osteoblast co-cultures and increased expression of RANK-L by osteoblasts. Norepinephrine 0-13 TNF superfamily member 11 Homo sapiens 197-203 19022290-1 2009 Biogenic amine transporters for serotonin, norepinephrine and dopamine (SERT, NET and DAT respectively), are the key players terminating transmission of these amines in the central nervous system by their high-affinity uptake. Norepinephrine 43-57 solute carrier family 6 member 3 Homo sapiens 86-89 19262750-2 2009 We have previously shown that OAMB, a Drosophila G-protein-coupled receptor for octopamine (the insect counterpart of mammalian norepinephrine), is required for ovulation induced upon mating. Norepinephrine 128-142 Octopamine receptor in mushroom bodies Drosophila melanogaster 30-34 18781277-6 2008 The results suggest that BDNF gene variation participates in regulation of norepinephrine turnover rates in the central nervous system of human subjects. Norepinephrine 75-89 brain derived neurotrophic factor Homo sapiens 25-29 18338249-3 2008 GATA-3 robustly transactivates the promoter function of the noradrenaline (NA)-synthesizing DBH gene, via two specific upstream promoter domains; one at -62 to -32 bp and the other at -891 to -853 bp. Norepinephrine 60-73 GATA binding protein 3 Homo sapiens 0-6 18620029-2 2008 In the present work we have studied in detail the regional and cellular localization of the dopamine D(4) receptor immunoreactivity (IR) in the rat cerebral cortex and its relationship to the dopaminergic and noradrenergic nerve terminal networks, since both dopamine and noradrenaline have a high affinity for this receptor. Norepinephrine 272-285 dopamine receptor D4 Rattus norvegicus 92-114 18636164-6 2008 We also evaluated the ability of norepinephrine to induce interleukin-6 (IL-6), interleukin-10 (IL-10), and vascular endothelial growth factor (VEGF). Norepinephrine 33-47 interleukin 10 Homo sapiens 80-94 18636164-6 2008 We also evaluated the ability of norepinephrine to induce interleukin-6 (IL-6), interleukin-10 (IL-10), and vascular endothelial growth factor (VEGF). Norepinephrine 33-47 interleukin 10 Homo sapiens 96-101 18543980-3 2008 Here, we built structural models of human transporters of dopamine, norepinephrine, and serotonin using the LeuT structure. Norepinephrine 68-82 Leucine transport, high Homo sapiens 108-112 18424435-3 2008 Indeed, AP-2beta null mice expressed significantly reduced levels of both noradrenaline (NA) and NA-synthesizing dopamine beta-hydroxylase in the peripheral nervous system. Norepinephrine 74-87 transcription factor AP-2 beta Mus musculus 8-16 21499463-13 2008 Propranolol treatment alone produced depression, and antagonized the effects of alprazolam and imipramine, even producing depression in combined treatments.In conclusion, our results reveal that alprazolam may produce antidepressant effects through the release of noradrenaline, which stimulates beta2 receptors to produce an antidepressant action. Norepinephrine 264-277 hemoglobin, beta adult minor chain Mus musculus 296-301 18172756-0 2008 BDNF level in the rat prefrontal cortex increases following chronic but not acute treatment with duloxetine, a dual acting inhibitor of noradrenaline and serotonin re-uptake. Norepinephrine 136-149 brain-derived neurotrophic factor Rattus norvegicus 0-4 18172756-2 2008 The brain level of BDNF is changed by several mood stabilizers and antidepressant drugs acting on neurotransmitters such as noradrenaline and serotonin. Norepinephrine 124-137 brain-derived neurotrophic factor Rattus norvegicus 19-23 18300261-1 2008 The alpha(2A)-adrenoceptor (AR) subtype, a G protein-coupled receptor located both pre- and postsynaptically, mediates adrenaline/noradrenaline functions. Norepinephrine 130-143 adrenoceptor alpha 2A Danio rerio 4-26 18300261-1 2008 The alpha(2A)-adrenoceptor (AR) subtype, a G protein-coupled receptor located both pre- and postsynaptically, mediates adrenaline/noradrenaline functions. Norepinephrine 130-143 adrenoceptor alpha 2A Danio rerio 28-30 18310473-5 2008 We confirmed that TAAR1 was activated by dopamine, norepinephrine, and serotonin and demonstrated that TAAR1 signaling was attenuated by monoamine autoreceptors at exposure to dopamine, norepinephrine, and serotonin. Norepinephrine 51-65 trace amine associated receptor 1 Homo sapiens 18-23 18310473-5 2008 We confirmed that TAAR1 was activated by dopamine, norepinephrine, and serotonin and demonstrated that TAAR1 signaling was attenuated by monoamine autoreceptors at exposure to dopamine, norepinephrine, and serotonin. Norepinephrine 186-200 trace amine associated receptor 1 Homo sapiens 103-108 18310473-6 2008 In transfected cells, TAAR1 in response to dopamine, norepinephrine, and serotonin significantly inhibited uptake and promoted efflux of [3H]dopamine, [3H]norepinephrine, and [3H]serotonin, respectively, whereas the monoamine autoreceptors, D2s, alpha(2A), and 5-HT(1B) enhanced the uptake function under the same condition. Norepinephrine 53-67 trace amine associated receptor 1 Homo sapiens 22-27 18310473-6 2008 In transfected cells, TAAR1 in response to dopamine, norepinephrine, and serotonin significantly inhibited uptake and promoted efflux of [3H]dopamine, [3H]norepinephrine, and [3H]serotonin, respectively, whereas the monoamine autoreceptors, D2s, alpha(2A), and 5-HT(1B) enhanced the uptake function under the same condition. Norepinephrine 155-169 trace amine associated receptor 1 Homo sapiens 22-27 18387300-1 2008 SAR for dual serotonin & noradrenaline reuptake inhibition. Norepinephrine 29-42 sarcosine dehydrogenase Homo sapiens 0-3 18056263-0 2008 Norepinephrine- and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytes. Norepinephrine 0-14 adrenoceptor beta 2 Homo sapiens 49-67 17681645-1 2008 Brain-derived neurotrophic factor (BDNF) synthesis in astrocytes induced by noradrenaline (NA) is a receptor-mediated process utilizing two parallel adrenergic pathways: beta1/beta2-adrenergic/cAMP and the novel alpha1-adrenergic/PKC pathway. Norepinephrine 76-89 brain-derived neurotrophic factor Rattus norvegicus 0-33 17681645-1 2008 Brain-derived neurotrophic factor (BDNF) synthesis in astrocytes induced by noradrenaline (NA) is a receptor-mediated process utilizing two parallel adrenergic pathways: beta1/beta2-adrenergic/cAMP and the novel alpha1-adrenergic/PKC pathway. Norepinephrine 76-89 brain-derived neurotrophic factor Rattus norvegicus 35-39 17726147-0 2007 Norepinephrine and rosiglitazone synergistically induce Elovl3 expression in brown adipocytes. Norepinephrine 0-14 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 Mus musculus 56-62 17726147-4 2007 By using primary cultures of brown adipocytes, we show here that the induced Elovl3 gene expression is synergistically regulated by norepinephrine and the peroxisome proliferator-activated receptor (PPAR) gamma ligand rosiglitazone. Norepinephrine 132-146 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 Mus musculus 77-83 17628002-6 2007 In contrast, the effect of TSA on the norepinephrine induction of the c-fos mRNA was stimulatory. Norepinephrine 38-52 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 70-75 17915260-3 2007 In isolated hippocampal neurons, norepinephrine (NE) application also increases the immunoreactivity of BDNF and several pro-survival signaling molecules. Norepinephrine 33-47 brain derived neurotrophic factor Homo sapiens 104-108 17557926-4 2007 We report the case of a 15-year-old girl with hypertension and a norepinephrine-secreting abdominal paraganglioma who was found to harbour a novel nonsense SDHC mutation, demonstrating that the clinical presentation of PGL3 syndrome can be more diverse than expected. Norepinephrine 65-79 succinate dehydrogenase complex subunit C Homo sapiens 156-160 17557926-4 2007 We report the case of a 15-year-old girl with hypertension and a norepinephrine-secreting abdominal paraganglioma who was found to harbour a novel nonsense SDHC mutation, demonstrating that the clinical presentation of PGL3 syndrome can be more diverse than expected. Norepinephrine 65-79 succinate dehydrogenase complex subunit C Homo sapiens 219-223 17565006-2 2007 Blockade of ectonucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) potentiates norepinephrine exocytosis, whereas recombinant soluble CD39 (solCD39) in-hibits it. Norepinephrine 91-105 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 12-60 17565006-2 2007 Blockade of ectonucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) potentiates norepinephrine exocytosis, whereas recombinant soluble CD39 (solCD39) in-hibits it. Norepinephrine 91-105 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 73-77 17092970-2 2007 The purpose of the present study was to investigate whether the G196A polymorphism of the brain-derived neurotrophic factor (BDNF) gene is associated with the antidepressant effect of milnacipran, a serotonin norepinephrine reuptake inhibitor, and fluvoxamine, a selective serotonin reuptake inhibitor. Norepinephrine 209-223 brain derived neurotrophic factor Homo sapiens 90-123 17092970-2 2007 The purpose of the present study was to investigate whether the G196A polymorphism of the brain-derived neurotrophic factor (BDNF) gene is associated with the antidepressant effect of milnacipran, a serotonin norepinephrine reuptake inhibitor, and fluvoxamine, a selective serotonin reuptake inhibitor. Norepinephrine 209-223 brain derived neurotrophic factor Homo sapiens 125-129 17327373-8 2007 We found that norepinephrine-induced lipolysis was positively correlated with HSL protein levels (P < 0.0001) but not with ATGL protein. Norepinephrine 14-28 lipase E, hormone sensitive type Homo sapiens 78-81 17664853-0 2007 High plasma norepinephrine levels associated with beta2-adrenoceptor polymorphisms predict future renal damage in nonobese normotensive individuals. Norepinephrine 12-26 adrenoceptor beta 2 Homo sapiens 50-68 17515698-12 2007 After administration of the COX 1 inhibitor SC 560, the arachidonic acid-induced vasopressor responses were significantly attenuated while U46619, angiotensin II, and norepinephrine-induced vasopressor, and PGE1-induced vasodepressor responses were not significantly altered. Norepinephrine 167-181 cytochrome c oxidase subunit I Felis catus 28-33 17515698-13 2007 After administration of the COX 2 inhibitor nimesulide, both the PGE 1 vasodepressor responses and arachidonic acid-induced vasopressor responses were significantly decreased while the U46619, angiotensin II, and norepinephrine-induced vasopressor responses were not significantly attenuated. Norepinephrine 213-227 cytochrome c oxidase subunit II Felis catus 28-33 17428549-3 2007 In two experiments using CD-1 mice, we demonstrate that intraperitoneal administration of IFN-alpha dose dependently influences plasma corticosterone and sickness behaviors, and modestly influences norepinephrine turnover in brain. Norepinephrine 198-212 interferon alpha Mus musculus 90-99 17318500-0 2007 The effects of both noradrenaline and CGP12177, mediated through human beta1 -adrenoceptors, are reduced by PDE3 in human atrium but PDE4 in CHO cells. Norepinephrine 20-33 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 71-76 16876982-0 2007 Norepinephrine induces BDNF and activates the PI-3K and MAPK cascades in embryonic hippocampal neurons. Norepinephrine 0-14 brain derived neurotrophic factor Homo sapiens 23-27 17056037-6 2006 Neurotensin produced a marked increase in coronary effluent norepinephrine release, an effect abolished by SR 48692, a specific neurotensin receptor antagonist. Norepinephrine 60-74 neurotensin Rattus norvegicus 0-11 17056037-6 2006 Neurotensin produced a marked increase in coronary effluent norepinephrine release, an effect abolished by SR 48692, a specific neurotensin receptor antagonist. Norepinephrine 60-74 neurotensin Rattus norvegicus 128-139 17056037-9 2006 In conclusion, these data indicate that following chronic beta-adrenoceptor activation, neurotensin-induced effects on norepinephrine release and subsequent contractile changes are markedly down-regulated. Norepinephrine 119-133 neurotensin Rattus norvegicus 88-99 16973367-2 2006 Efforts to design selective norepinephrine reuptake inhibitors based on SAR from the aryloxypropanamine series of monoamine reuptake inhibitors have led to the identification of a potent new class of dual acting norepinephrine and serotonin reuptake inhibitors, namely the 3-(1H-indol-1-yl)-3-arylpropan-1-amines. Norepinephrine 28-42 sarcosine dehydrogenase Homo sapiens 72-75 16973367-2 2006 Efforts to design selective norepinephrine reuptake inhibitors based on SAR from the aryloxypropanamine series of monoamine reuptake inhibitors have led to the identification of a potent new class of dual acting norepinephrine and serotonin reuptake inhibitors, namely the 3-(1H-indol-1-yl)-3-arylpropan-1-amines. Norepinephrine 212-226 sarcosine dehydrogenase Homo sapiens 72-75 16788141-11 2006 We conclude that decreases in UT-A1, AQP2, and NKCC2/BSC1 proteins may contribute to the diuresis and natriuresis that occur following ANG II or norepinephrine-induced acute hypertension and do not appear to involve ANG II stimulation of aldosterone or thirst. Norepinephrine 145-159 solute carrier family 12 member 1 Rattus norvegicus 47-52 16788141-11 2006 We conclude that decreases in UT-A1, AQP2, and NKCC2/BSC1 proteins may contribute to the diuresis and natriuresis that occur following ANG II or norepinephrine-induced acute hypertension and do not appear to involve ANG II stimulation of aldosterone or thirst. Norepinephrine 145-159 solute carrier family 12 member 1 Rattus norvegicus 53-57 16672216-7 2006 These changes likely result from increased sympathetic nervous system activity rather than adipose cell-autonomous effects, as we found that XLalphas is not normally expressed in adult adipose tissue, and Gnasxl(m+/p-) mice had increased urinary norepinephrine levels but not increased metabolic responsiveness to a beta3-adrenergic agonist. Norepinephrine 246-260 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Mus musculus 205-211 16569708-2 2006 Although inactive in itself, the neuropeptide corticotropin releasing factor (CRF) strongly amplified the effect of BDNF, increasing the number of cells expressing TH and the active accumulation of noradrenaline by a factor of 2 to 3 via a mechanism that was nonmitogenic. Norepinephrine 198-211 brain derived neurotrophic factor Homo sapiens 116-120 16774125-2 2006 However, N-type Ca2+ channel alpha1B-deficient mice with a CBA/JN background show normal plasma norepinephrine and epinephrine levels, presumably owing to compensation by other gene(s). Norepinephrine 96-110 calcium channel, voltage-dependent, N type, alpha 1B subunit Mus musculus 29-36 16774125-5 2006 These results suggest that the compensatory mechanisms to maintain normal levels of epinephrine and norepinephrine in the adrenal gland of N-type Ca2+ channel alpha1B-deficient mice include increased expression of alpha1A and beta4 subunits and increased catecholamine biosynthetic activity. Norepinephrine 100-114 calcium channel, voltage-dependent, N type, alpha 1B subunit Mus musculus 159-166 17073682-3 2006 The fact that all three monoamine (dopamine, norepinephrine, and serotonin) transporters (DAT, NET and SERT) are involved in various neurological and psychiatric diseases further emphasizes the need to develop suitable NET ligands so that researchers will be able to probe the contributions of each monoamine transporter system to specific CNS disorders. Norepinephrine 45-59 solute carrier family 6 member 3 Homo sapiens 90-93 16722229-3 2006 Cotransport in norepinephrine (NET), epinephrine (EpiT), dopamine (DAT), and serotonin (SERT) transporters couples downhill Na+ flux to uphill transmitter flux. Norepinephrine 15-29 solute carrier family 6 member 3 Homo sapiens 67-70 16722235-11 2006 The TEs of OCT1 and OCT2 for dopamine, noradrenaline, adrenaline and 5-HT in general are rather low, in the range relative to MPP+ of 5%-15%. Norepinephrine 39-52 solute carrier family 22 member 1 Rattus norvegicus 11-15 16368196-5 2006 Furthermore the same dose of N-methyl-D-aspartic acid induced a significant increase in cyclic GMP for 30 min (P<0.05), as well as in acetylcholine (P<0.001) and norepinephrine for 15 min (P<0.001). Norepinephrine 168-182 5'-nucleotidase, cytosolic II Homo sapiens 95-98 16368196-8 2006 These results suggested that nitric oxide release in the LDT induced by activation of the N-methyl-D-aspartic acid receptor on the cholinergic neurons of the LDT, then through the cyclic GMP system, facilitates norepinephrine release from the terminals of noradrenergic neurons in the locus coeruleus. Norepinephrine 211-225 5'-nucleotidase, cytosolic II Homo sapiens 187-190 16359723-6 2005 Furthermore, as with selective serotonin reuptake inhibitors such as fluvoxamine and paroxetine, SIV was also reduced by the serotonin and noradrenaline reuptake inhibitor milnacipran and the metabotropic glutamate receptor 5 antagonist MPEP, while desipramine was without effect. Norepinephrine 139-152 glutamate metabotropic receptor 5 Rattus norvegicus 192-225 16237719-9 2005 In the medial prefrontal cortex of AQP4-knockout mice, the levels of serotonin and norepinephrine were increased, but no significant change in dopamine level was found. Norepinephrine 83-97 aquaporin 4 Mus musculus 35-39 16280290-0 2005 Rebound weight gain as associated with high plasma norepinephrine levels that are mediated through polymorphisms in the beta2-adrenoceptor. Norepinephrine 51-65 adrenoceptor beta 2 Homo sapiens 120-138 15855229-3 2005 In cultured brown adipocytes, a mixture of norepinephrine, dexamethasone, and the PPARalpha ligand Wy-14643, which rendered the adipocytes a high oxidative state, was required for substantial induction of Elovl3 expression, whereas the same treatment suppressed Elovl1 mRNA levels. Norepinephrine 43-57 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 Mus musculus 205-211 15855229-3 2005 In cultured brown adipocytes, a mixture of norepinephrine, dexamethasone, and the PPARalpha ligand Wy-14643, which rendered the adipocytes a high oxidative state, was required for substantial induction of Elovl3 expression, whereas the same treatment suppressed Elovl1 mRNA levels. Norepinephrine 43-57 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1 Mus musculus 262-268 15894570-3 2005 However, NGF also facilitates synaptic transmission and norepinephrine uptake, effects that would be expected to restrain such deleterious outcomes. Norepinephrine 56-70 nerve growth factor Mus musculus 9-12 15894570-10 2005 In conclusion, overexpression of NGF in heart leads to sympathetic hyperinnervation that is not associated with detrimental effects on LV performance and is likely due to concomitantly enhanced norepinephrine neuronal uptake. Norepinephrine 194-208 nerve growth factor Mus musculus 33-36 16159376-6 2005 The number of double-labelled tyrosine hydroxylase/Fos immunoreactive neurones in locus coeruleus was significantly higher at 14.00 h of oestrus, suggesting an increase in its activity preceding the prolactin surge that generally occurs at 15.00 h. Therefore, the increase in locus coeruleus activity on the afternoon of oestrus supports the data obtained with bilateral lesion of this nucleus, suggesting a stimulatory role of locus coeruleus norepinephrine in the genesis of the secondary surge of prolactin. Norepinephrine 444-458 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 51-54 16264397-6 2005 RESULTS: BAT strongly inhibited the non-stimulated and norepinephrine - stimulated melatonin secretion from the pig and rat pineal explants, with ED50 0.3 - 0.7 microM. Norepinephrine 55-69 bile acid CoA:amino acid N-acyltransferase Rattus norvegicus 9-12 16264397-9 2005 The half-time of BAT-induced decline in the non - stimulated and norepinephrine-stimulated melatonin secretion was ca. Norepinephrine 65-79 bile acid CoA:amino acid N-acyltransferase Rattus norvegicus 17-20 16154127-8 2005 In conclusion, neurotensin increases ventricular contractility through stimulation of myocardial norepinephrine release. Norepinephrine 97-111 neurotensin Rattus norvegicus 15-26 15894566-9 2005 Notably, rAdv.heNOS decreased plasma levels of norepinephrine and plasma renin activity in cold-exposed rats, which suggests that eNOS gene transfer may decrease the activities of the sympathetic nervous system and the renin-angiotensin system. Norepinephrine 47-61 nitric oxide synthase 3 Rattus norvegicus 15-19 15970488-10 2005 The sympathetic nervous system and gut-derived norepinephrine mediate the pro-inflammatory effects by activating alpha2A-adrenoceptor on Kupffer cells. Norepinephrine 47-61 adrenoceptor alpha 2A Homo sapiens 113-133 16141665-7 2005 Norepinephrine (NE, 10 microM) stimulated the redistribution of RhoA from the cytosolic to the membrane fraction in swine pulmonary artery smooth muscle. Norepinephrine 0-14 ras homolog family member A Sus scrofa 64-68 15845618-7 2005 These results indicate that TRalpha is necessary for T(3) to modulate the central control of T(C) and for an essential step in norepinephrine activation of BAT thermogenesis but not to sustain obligatory thermogenesis. Norepinephrine 127-141 guanine nucleotide binding protein, alpha transducing 1 Mus musculus 28-35 15950014-6 2005 In brain regions expressing both the DAT and the norepinephrine transporter (NET), the relative contributions of dopamine and norepinephrine to ADHD pathophysiology and therapeutic response are obfuscated by the capacity of the NET to clear dopamine as well as norepinephrine. Norepinephrine 126-140 solute carrier family 6 member 3 Homo sapiens 37-40 15911163-1 2005 The alpha2A and alpha2C adrenergic receptor (AR) subtypes mediate antinociception when activated by the endogenous ligand norepinephrine. Norepinephrine 122-136 adrenergic receptor, alpha 2c Mus musculus 16-43 15763132-1 2005 Pre-synaptic norepinephrine (NE) and dopamine (DA) transporters (NET and DAT) terminate catecholamine synaptic transmission through reuptake of released neurotransmitter. Norepinephrine 13-27 solute carrier family 6 member 3 Homo sapiens 73-76 15763138-3 2005 We investigated whether substrates (dopamine, norepinephrine) of the human dopamine (hDAT) and norepinephrine (hNET) transporters can directly induce c-Fos protein in HEK-293 (HEK) cells transfected with the hDAT and hNET and whether PKC modulators affect this process. Norepinephrine 46-60 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 150-155 15763138-4 2005 Dopamine and norepinephrine robustly induced c-Fos immunofluorescence in both hDAT and hNET cells, but not in untransfected HEK-293 cells, demonstrating that catecholamine-induced c-Fos induction was DAT- and NET-dependent. Norepinephrine 13-27 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 45-50 15763138-4 2005 Dopamine and norepinephrine robustly induced c-Fos immunofluorescence in both hDAT and hNET cells, but not in untransfected HEK-293 cells, demonstrating that catecholamine-induced c-Fos induction was DAT- and NET-dependent. Norepinephrine 13-27 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 180-185 15763138-4 2005 Dopamine and norepinephrine robustly induced c-Fos immunofluorescence in both hDAT and hNET cells, but not in untransfected HEK-293 cells, demonstrating that catecholamine-induced c-Fos induction was DAT- and NET-dependent. Norepinephrine 13-27 solute carrier family 6 member 3 Homo sapiens 79-82 15763138-7 2005 BIS pretreatment abolished norepinephrine-induced c-Fos expression hNET but not dopamine-induced c-Fos induction in hDAT cells. Norepinephrine 27-41 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 50-55 15763138-8 2005 In conclusion, induction of c-Fos by dopamine and norepinephrine requires the presence of hDAT and hNET but the contributions of hDAT and hNET to c-Fos induction is distinguishable on the basis of differing responses to a PKC inhibitor. Norepinephrine 50-64 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 28-33 15756641-4 2005 beta2AR activation by epinephrine, norepinephrine, and salbutamol suppressed the IgE receptor-dependent release of histamine, lipid mediators, and TNF-alpha, and inhibited SCF-dependent MC proliferation and migration. Norepinephrine 35-49 adrenoceptor beta 2 Homo sapiens 0-7 15756641-4 2005 beta2AR activation by epinephrine, norepinephrine, and salbutamol suppressed the IgE receptor-dependent release of histamine, lipid mediators, and TNF-alpha, and inhibited SCF-dependent MC proliferation and migration. Norepinephrine 35-49 KIT ligand Homo sapiens 172-175 15608072-9 2005 Entrapping the recombinant activated tyrosine kinase pp60(c-Src) strongly potentiated the release of norepinephrine elicited by NMDA/glycine in Mg2+-free medium but failed to permit NMDA receptor activation in presence of external Mg2+ ions. Norepinephrine 101-115 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 58-63 15615865-7 2005 In functional studies, coexpression with beta2-AR significantly enhanced the coupling of alpha1D-AR to norepinephrine-stimulated Ca2+ mobilization. Norepinephrine 103-117 adrenoceptor beta 2 Homo sapiens 41-49 15725340-7 2005 Therefore, corticosterone potentiates noradrenaline-induced melatonin and NAS production through GR inhibition of NFkappaB nuclear translocation. Norepinephrine 38-51 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 97-99 16097416-1 2005 OBJECTIVE: To examine if the decline in post-ischemic hyperemic flow after repeated brief periods of myocardial ischemia is accompanied by augmented cardiac release of the vasoconstrictors endothelin-1 (ET-1) and norepinephrine (NE). Norepinephrine 213-227 endothelin-1 Sus scrofa 203-207 15762558-0 2005 Dopamine-, L-DOPA-, adrenaline-, and noradrenaline-induced growth of Au nanoparticles: assays for the detection of neurotransmitters and of tyrosinase activity. Norepinephrine 37-50 tyrosinase Homo sapiens 140-150 15652511-3 2005 Here, we demonstrate stimulations with GPCR agonists (norepinephrine, angiotensin II, and endothelin 1) and phorbol ester activated and translocated protein kinase D1 (PKD1) to the Z-discs in neonatal rat cardiomyocytes in a protein kinase C (PKC)-dependent manner, whereas gp130 agonist did not. Norepinephrine 54-68 protein kinase D1 Rattus norvegicus 149-166 16027803-3 2005 Experiments with combined application of acetylcholine and norepinephrine against the background of ouabain showed that the nonspecific action of the test neurotransmitters is related to modulation of Na/K-ATPase activity. Norepinephrine 59-73 ATPase Na+/K+ transporting subunit alpha 1 Gallus gallus 201-212 15602689-4 2004 Norepinephrine release mediated by MDMA creates a double-edged sword of heat generation through activation of uncoupling protein (UCP3) along with alpha1- and beta3-adrenoreceptors and loss of heat dissipation through SNS-mediated vasoconstriction. Norepinephrine 0-14 uncoupling protein 3 Homo sapiens 130-134 15466664-8 2004 In vitro alpha(1)AR mesenteric microvascular contractile responses to endogenous norepinephrine (NE; elicited by electrical field stimulation 10 Hz) was markedly depressed in alpha(1B)AR KO mice compared with WT (12.4+/-1.7% versus 21.5+/-1.2%; P<0.001). Norepinephrine 81-95 calcium channel, voltage-dependent, N type, alpha 1B subunit Mus musculus 175-183 15126242-9 2004 The glucagon and norepinephrine responses to insulin-induced hypoglycemia are blunted in late pregnancy in the dog, impacting on the magnitude of the metabolic responses to the fall in glucose. Norepinephrine 17-31 insulin Canis lupus familiaris 45-52 15322265-1 2004 The neurotoxin 1-methyl-4-(2"-aminophenyl)-1,2,3,6-tetrahydropyridine (2"-NH(2)-MPTP) damages forebrain serotonin (5-HT) and norepinephrine (NE) nerve terminals while sparing striatal dopaminergic innervation. Norepinephrine 125-139 protein tyrosine phosphatase, non-receptor type 2 Mus musculus 80-84 15249992-7 2004 Moreover, Western blot analysis revealed a peak expression of c-fos in the right and left ventricles after naloxone-precipitated withdrawal in parallel with an increase in noradrenaline (NA) turnover. Norepinephrine 172-185 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 62-67 15145188-0 2004 Increased norepinephrine production associated with burn injuries results in CCL2 production and type 2 T cell generation. Norepinephrine 10-24 chemokine (C-C motif) ligand 2 Mus musculus 77-81 15145188-3 2004 In this study, influence of norepinephrine (NE) on CCL2 production in mice early after thermal injury (TI) was investigated. Norepinephrine 28-42 chemokine (C-C motif) ligand 2 Mus musculus 51-55 15145612-1 2004 Endogenous catecholamine, epinephrine and norepinephrine, and isoproterenol concentration-dependently induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, and inhibited that of IL-10 in human peripheral blood mononuclear cells (PBMC). Norepinephrine 42-56 interleukin 18 Homo sapiens 128-147 15145612-1 2004 Endogenous catecholamine, epinephrine and norepinephrine, and isoproterenol concentration-dependently induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, and inhibited that of IL-10 in human peripheral blood mononuclear cells (PBMC). Norepinephrine 42-56 interleukin 10 Homo sapiens 233-238 15145612-6 2004 Epinephrine/norepinephrine/isoproterenol/beta 2-AR agonists increased the production of IL-18 in monocytes, but had no effect on IL-12, TNF-alpha, IFN-gamma and IL-10 production. Norepinephrine 12-26 interleukin 18 Homo sapiens 88-93 15125834-1 2004 Norepinephrine released by the sympathetic nerve terminals regulates the immune system primarily via its stimulation of beta(2)-adrenergic receptor (beta(2)AR), but the underlying molecular mechanisms remain to be elicited. Norepinephrine 0-14 adrenoceptor beta 2 Homo sapiens 120-147 15125834-1 2004 Norepinephrine released by the sympathetic nerve terminals regulates the immune system primarily via its stimulation of beta(2)-adrenergic receptor (beta(2)AR), but the underlying molecular mechanisms remain to be elicited. Norepinephrine 0-14 adrenoceptor beta 2 Homo sapiens 149-158 15066288-5 2004 The role of norepinephrine in retrieval requires signaling through the beta(1)-adrenergic receptor in the hippocampus. Norepinephrine 12-26 adrenergic receptor, beta 1 Mus musculus 71-98 15009661-6 2004 We found that the levels of noradrenaline were significantly increased in the limbic forebrain of TTR-null mice. Norepinephrine 28-41 transthyretin Mus musculus 98-101 14744802-13 2004 Atenolol (beta(1)-adrenoceptor antagonist) blocked the noradrenaline-induced effects, but butoxamine (beta(2)-adrenoceptor antagonist) did not. Norepinephrine 55-68 adrenergic receptor, beta 1 Mus musculus 10-30 15017115-10 2004 CONCLUSION: These results reveal that glucose able to induce hypertension and provide evidence that glucose inhibits the transcriptions of both 11beta-HSD2 and CYP 11B2 in vasculature, leading to lower aldosterone and higher corticosterone production in vessels, and increased vasoconstrictor responses to norepinephrine. Norepinephrine 306-320 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 144-155 15017115-10 2004 CONCLUSION: These results reveal that glucose able to induce hypertension and provide evidence that glucose inhibits the transcriptions of both 11beta-HSD2 and CYP 11B2 in vasculature, leading to lower aldosterone and higher corticosterone production in vessels, and increased vasoconstrictor responses to norepinephrine. Norepinephrine 306-320 cytochrome P450, family 11, subfamily b, polypeptide 2 Rattus norvegicus 160-168 12866809-4 2002 In some tissues alpha1A- or alpha1D-adrenoceptors were "protected" from inactivation by incubation in the presence of the selective alpha1A- or 1D-adrenoceptor antagonists 5-methylurapidil and BMY 7378 before recording further responses to noradrenaline. Norepinephrine 240-253 calcium voltage-gated channel subunit alpha1 A Homo sapiens 16-23 12866809-4 2002 In some tissues alpha1A- or alpha1D-adrenoceptors were "protected" from inactivation by incubation in the presence of the selective alpha1A- or 1D-adrenoceptor antagonists 5-methylurapidil and BMY 7378 before recording further responses to noradrenaline. Norepinephrine 240-253 calcium voltage-gated channel subunit alpha1 A Homo sapiens 132-139 12239109-0 2002 Expression of estrogen receptor-alpha and cFos in norepinephrine and epinephrine neurons of young and middle-aged rats during the steroid-induced luteinizing hormone surge. Norepinephrine 50-64 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 42-46 12215478-7 2002 Preganglionic electrical stimulation (0.5 Hz) raised basal norepinephrine levels 11-fold and further enhanced the angiotensin-induced increase in norepinephrine (4.04 ng/mL at 1 microg/kg ANG). Norepinephrine 146-160 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 Mus musculus 170-177 12186683-9 2002 Stress decreased dopaminergic activity in the frontal cortex and amygdala of males but not females; whereas, in CA3 of the hippocampus, stress increased levels of 5-HT and norepinephrine in females, but not males, and increased GABA in males, but not females. Norepinephrine 172-186 carbonic anhydrase 3 Rattus norvegicus 112-115 12124378-3 2002 This tyrosine residue is conserved within the third transmembrane domain in members of the Na(+):neurotransmitter transporter family (SNF), where it plays a role in binding pharmacological ligands such as cocaine to the serotonin (SERT), dopamine (DAT) and norepinephrine (NET) transporters. Norepinephrine 257-271 small nuclear ribonucleoprotein polypeptide A S homeolog Xenopus laevis 134-137 12124378-3 2002 This tyrosine residue is conserved within the third transmembrane domain in members of the Na(+):neurotransmitter transporter family (SNF), where it plays a role in binding pharmacological ligands such as cocaine to the serotonin (SERT), dopamine (DAT) and norepinephrine (NET) transporters. Norepinephrine 257-271 solute carrier family 6 (neurotransmitter transporter), member 3 S homeolog Xenopus laevis 248-251 12170059-10 2002 CONCLUSION: These results suggest that one mechanism by which nAChR agonists act for analgesia is to stimulate spinal norepinephrine release. Norepinephrine 118-132 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 62-67 11916794-2 2002 To study the effects of tramadol on norepinephrine transporter (NET) function, we assayed the effect of tramadol on [3H]-norepinephrine ([3H]-NE) uptake and [3H]-desipramine binding to plasma membranes isolated from bovine adrenal medulla. Norepinephrine 36-50 solute carrier family 6 member 2 Bos taurus 64-67 11940765-16 2002 Noradrenaline increased intracellular Ca2+ concentration ([Ca2+]i) concentration-dependently, which was inhibited by ONOO-1 in alpha1a- and alpha1d-adrenoceptors. Norepinephrine 0-13 calcium voltage-gated channel subunit alpha1 A Homo sapiens 127-134 11940765-20 2002 Treatment with ONOO-1 attenuates noradrenaline-stimulated increase in [Ca2+]i in alpha1a- and alpha1d-adrenoceptors but not in alpha1b-adrenoceptor. Norepinephrine 33-46 calcium voltage-gated channel subunit alpha1 A Homo sapiens 81-88 11940765-21 2002 ONOO-1 also weakens noradrenaline-induced contractions in rat aorta that has alpha1a- and alpha1d-adrenoceptors. Norepinephrine 20-33 calcium voltage-gated channel subunit alpha1 A Homo sapiens 77-84 11985823-5 2002 Comparison of synaptosomal and slice preparations, as well as examination of the effects of tetrodotoxin, indicated that at least two nicotinic acetylcholine receptor populations regulated [(3)H]norepinephrine release from neonatal and adult hippocampus; one localized on noradrenergic terminals, the other on adjacent cells. Norepinephrine 195-209 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 134-166 11896172-7 2002 A postmortem examination in GluRepsilon4 mutant mice revealed that tissue contents of norepinephrine, dopamine, serotonin, and their metabolites were reduced in the hippocampus and that dopamine, as well as serotonin, metabolism was upregulated in the frontal cortex, striatum, hippocampus, and thalamus. Norepinephrine 86-100 glutamate receptor, ionotropic, NMDA2D (epsilon 4) Mus musculus 28-40 12361188-1 2002 OBJECTIVE: Since beta2-adrenergic receptors (beta2AR) can influence blood pressure not only by vasodilation, but also participate in noradrenaline release from sympathetic nerve endings, we have studied whether Arg16Gly polymorphism of the beta2AR gene is associated with predisposition to essential hypertension and increased plasma noradrenaline concentration in offspring from normotensive (SN) and hypertensive parents (SH). Norepinephrine 133-146 adrenoceptor beta 2 Homo sapiens 17-43 12361188-1 2002 OBJECTIVE: Since beta2-adrenergic receptors (beta2AR) can influence blood pressure not only by vasodilation, but also participate in noradrenaline release from sympathetic nerve endings, we have studied whether Arg16Gly polymorphism of the beta2AR gene is associated with predisposition to essential hypertension and increased plasma noradrenaline concentration in offspring from normotensive (SN) and hypertensive parents (SH). Norepinephrine 133-146 adrenoceptor beta 2 Homo sapiens 45-52 12361188-1 2002 OBJECTIVE: Since beta2-adrenergic receptors (beta2AR) can influence blood pressure not only by vasodilation, but also participate in noradrenaline release from sympathetic nerve endings, we have studied whether Arg16Gly polymorphism of the beta2AR gene is associated with predisposition to essential hypertension and increased plasma noradrenaline concentration in offspring from normotensive (SN) and hypertensive parents (SH). Norepinephrine 334-347 adrenoceptor beta 2 Homo sapiens 17-43 11799094-5 2002 The norepinephrine-induced increase in 8-epi-PGF(2alpha) levels could be completely normalized by 3 different classes of antihypertensive drugs: prazosin, an alpha-adrenergic receptor blocker; hydralazine, a nonspecific vasodilator; and losartan, a specific angiotensin type 1 (AT(1)) receptor antagonist. Norepinephrine 4-18 placental growth factor Rattus norvegicus 45-48 11799094-8 2002 In summary, continuous infusion of both Ang II and norepinephrine potently increases plasma levels of 8-epi-PGF(2alpha) and thus in vivo oxidative stress. Norepinephrine 51-65 placental growth factor Rattus norvegicus 108-111 11799094-9 2002 Ang II and norepinephrine seem to induce this increase in 8-epi-PGF(2alpha) via mechanisms with different pressor dependencies. Norepinephrine 11-25 placental growth factor Rattus norvegicus 64-67 11739254-10 2001 Locally administered gastrin-17 and sulfated cholecystokinin-8 mobilized histamine as did pituitary adenylate cyclase-activating peptide-27, vasoactive intestinal peptide, peptide YY, met-enkephalin, endothelin and noradrenaline, adrenaline and isoprenaline. Norepinephrine 215-228 gastrin Rattus norvegicus 21-28 11739254-12 2001 While gastrin, sulfated-cholecystokinin-8, met-enkephalin and isoprenaline induced a sustained elevation of the submucosal histamine concentration, endothelin, peptide YY, pituitary adenylate cyclase activating peptide, vasoactive intestinal peptide, noradrenaline and adrenaline induced a transient elevation. Norepinephrine 251-264 gastrin Rattus norvegicus 6-13 11710758-5 2001 Urinary epinephrine and norepinephrine excretion was significantly higher in the LPD high-sucrose group than in the NPD and LPD low-sucrose groups, and there was a significant positive correlation between urinary norepinephrine excretion and systolic blood pressure. Norepinephrine 24-38 acyl-CoA synthetase bubblegum family member 1 Rattus norvegicus 81-84 11710758-5 2001 Urinary epinephrine and norepinephrine excretion was significantly higher in the LPD high-sucrose group than in the NPD and LPD low-sucrose groups, and there was a significant positive correlation between urinary norepinephrine excretion and systolic blood pressure. Norepinephrine 213-227 acyl-CoA synthetase bubblegum family member 1 Rattus norvegicus 81-84 11585676-2 2001 The beta-AR signal system is one of the most powerful regulators of cardiac function, mediated by the effects of the sympathetic transmitters epinephrine and norepinephrine. Norepinephrine 158-172 adrenergic receptor, beta 1 Mus musculus 4-11 11429392-4 2001 5-Methyl-urapidil competitively antagonized responses to noradrenaline with a pK(B) value of 8.48 and a Schild slope of 0.99, consistent with the presence of alpha(1A)-adrenoceptors. Norepinephrine 57-70 calcium voltage-gated channel subunit alpha1 A Homo sapiens 158-166 11427501-0 2001 Antiproliferative action of dopamine and norepinephrine in neuroblastoma cells expressing the human dopamine transporter. Norepinephrine 41-55 solute carrier family 6 member 3 Homo sapiens 100-120 11408527-7 2001 Norepinephrine is known to activate alpha1-adrenoceptors and PKC. Norepinephrine 0-14 protein kinase C, gamma Rattus norvegicus 61-64 11459117-0 2001 Adrenomedullin inhibits the pressor effects and decrease in renal blood flow induced by norepinephrine or angiotensin II in anesthetized rats. Norepinephrine 88-102 adrenomedullin Rattus norvegicus 0-14 11390028-3 2001 We have found: ACP-1 inhibited both dopamine and norepinephrine release; ACP-2 inhibited dopamine release, without affecting norepinephrine release; ACP-3 was almost ineffective, except for a weak dopamine inhibiting effect only at a higher concentration. Norepinephrine 49-63 acid phosphatase 1 Rattus norvegicus 15-20 11278912-0 2001 Phospholipase D activation by norepinephrine is mediated by 12(s)-, 15(s)-, and 20-hydroxyeicosatetraenoic acids generated by stimulation of cytosolic phospholipase a2. Norepinephrine 30-44 cytosolic phospholipase A2 Oryctolagus cuniculus 141-167 11440275-7 2001 Adrenomedullin levels correlated with plasma noradrenaline (r = 0.516, p = 0.0124). Norepinephrine 45-58 adrenomedullin Homo sapiens 0-14 11440275-11 2001 CONCLUSIONS: This study demonstrates that circulating adrenomedullin is increased in pheochromocytoma, and is also correlated with plasma noradrenaline levels. Norepinephrine 138-151 adrenomedullin Homo sapiens 54-68 11306173-5 2001 When HB2 cells were stimulated by norepinephrine, the VEGF mRNA level increased without a change in that of VEGF-B, while the VEGF-C mRNA level decreased. Norepinephrine 34-48 vascular endothelial growth factor A Mus musculus 54-58 11171649-4 2001 We observed that ET-1 (8 x 10(-10) M) significantly amplified the concentration-dependent (10(-7)-10(-5) M) skin vasoconstrictor effect of norepinephrine. Norepinephrine 139-153 endothelin-1 Sus scrofa 17-21 11284440-11 2001 ), a reference PAF receptor antagonist, completely prevented the LPS-induced cardiovascular collapse and abolished the sharp reductions of the arterial blood pressure and CO responses to noradrenaline observed during endotoxaemia. Norepinephrine 187-200 PCNA clamp associated factor Rattus norvegicus 15-18 11226400-2 2001 Endothelin-1 (10(-10) M) potentiated the contractions induced by electrical stimulation and noradrenaline. Norepinephrine 92-105 endothelin-1 Oryctolagus cuniculus 0-12 11226400-6 2001 The results indicate that endothelin-1 potentiates the responses to electrical stimulation and noradrenaline by activating endothelin ET(B) receptors. Norepinephrine 95-108 endothelin-1 Oryctolagus cuniculus 26-38 11153756-12 2001 In the presence of norepinephrine, inhibition of beta1-adrenoceptors increased the amount of protein kinase C-alpha and -delta isoforms translocated into the particulate fraction. Norepinephrine 19-33 protein kinase C, alpha Rattus norvegicus 93-126 11179598-1 2001 Central administration of bombesin (BN) (into the ventricular system) increased circulating levels of ACTH, corticosterone, epinephrine, norepinephrine and glucose, indicating that this peptide activates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system. Norepinephrine 137-151 gastrin releasing peptide Homo sapiens 26-34 11179598-1 2001 Central administration of bombesin (BN) (into the ventricular system) increased circulating levels of ACTH, corticosterone, epinephrine, norepinephrine and glucose, indicating that this peptide activates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system. Norepinephrine 137-151 gastrin releasing peptide Homo sapiens 36-38 11150503-5 2000 Western blotting of cytosolic and nuclear protein extracts from cultured differentiated brown adipocytes showed that HO-1 and HO-2 are indeed localized in the cytosol and nuclei of brown adipocytes, and that noradrenaline stimulation significantly increased their amount in cytosol but not in the nuclear fraction. Norepinephrine 208-221 heme oxygenase 1 Rattus norvegicus 117-130 11269921-3 2000 The effect of exogenous NPY (10 nM) on EFS (8 Hz, 0.3 ms, 12 V, for 1 min)-evoked overflow of noradrenaline (NA) was also studied using an HPLC technique with electrochemical detection. Norepinephrine 94-107 pro-neuropeptide Y Cavia porcellus 24-27 11104823-3 2000 We have studied the effect of CART peptide-(55-102) and TRH on basal and depolarization (K+ 15 mM)-induced norepinephrine and dopamine release from rat hypothalamic neuronal endings (synaptosomes) in vitro. Norepinephrine 107-121 CART prepropeptide Rattus norvegicus 30-34 11046223-14 2000 The interaction of intravenous anesthetics with NET may modulate the neuronal transmission of norepinephrine during anesthesia. Norepinephrine 94-108 solute carrier family 6 member 2 Bos taurus 48-51 11032873-5 2000 Both sodium propionate and 5-(N,N-hexamethylene)amiloride (HMA), two treatments that abolished the effect of norepinephrine on cytoplasmic alkalization, also reduced norepinephrine-mediated increases in membrane-associated PKCalpha, delta, and epsilon. Norepinephrine 109-123 protein kinase C, alpha Rattus norvegicus 223-231 11032873-5 2000 Both sodium propionate and 5-(N,N-hexamethylene)amiloride (HMA), two treatments that abolished the effect of norepinephrine on cytoplasmic alkalization, also reduced norepinephrine-mediated increases in membrane-associated PKCalpha, delta, and epsilon. Norepinephrine 166-180 protein kinase C, alpha Rattus norvegicus 223-231 11003990-5 2000 The binding capacity of NK cells to a CD44 ligand, hyaluronate, was reduced by the stimulation with norepinephrine (P < 0.01). Norepinephrine 100-114 CD44 molecule (Indian blood group) Homo sapiens 38-42 11003990-6 2000 The intravenous injection of norepinephrine in mice decreased the expression of CD44 and CD18 on CD3(-)NK1.1(+) cells (P < 0.01) and increased the number of CD3(-)NK1.1(+) cells in PBMC (P < 0.01). Norepinephrine 29-43 CD44 antigen Mus musculus 80-84 10993216-5 2000 These results suggest that serotonin and noradrenaline are likely involved in the modulation of the expression of Fos-ir cells in response to the urine in the accessory olfactory bulb. Norepinephrine 41-54 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 114-117 10893647-10 2000 Functional affinity of each antagonist suggested that noradrenaline-induced contractions were mainly mediated by alpha 1L-AR in the human prostate and by alpha 1B-AR in the mesenteric artery. Norepinephrine 54-67 adrenoceptor alpha 1B Homo sapiens 154-165 10882842-6 2000 These results suggest that clozapine and olanzapine increase noradrenaline release by stimulating noradrenergic neuronal activity in the locus coeruleus and, consequently, increased noradrenaline induce Fos expression in the mPFC via beta-adrenergic receptors. Norepinephrine 182-195 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 203-206 10878345-0 2000 Activation of antigen-specific CD4+ Th2 cells and B cells in vivo increases norepinephrine release in the spleen and bone marrow. Norepinephrine 76-90 CD4 antigen Mus musculus 31-34 10820200-2 2000 In cells stably expressing alpha(1A)-adrenergic receptors, norepinephrine activated all five reporters [AP1 (activator protein-1), SRE (serum response element), CRE (cyclic AMP response element), NFkappaB) (nuclear factor-kappaB), and NFAT (nuclear factor of activated T cells)], whereas nerve growth factor (NGF) and epidermal growth factor activated only AP1 and SRE. Norepinephrine 59-73 calcium voltage-gated channel subunit alpha1 A Homo sapiens 27-35 10820200-7 2000 inhibition of Src eliminated SRE responses to norepinephrine and NGF, and reduced all responses except CRE. Norepinephrine 46-60 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 14-17 11021986-0 2000 Effect of corticotropin releasing factor receptor 1 antagonist on extracellular norepinephrine, dopamine and serotonin in hippocampus and prefrontal cortex of rats in vivo. Norepinephrine 80-94 corticotropin releasing hormone receptor 1 Rattus norvegicus 10-51 10959006-0 2000 Neuropeptide Y is a cotransmitter with norepinephrine in guinea pig inferior mesenteric vein. Norepinephrine 39-53 pro-neuropeptide Y Cavia porcellus 0-14 10959006-1 2000 Neuropeptide Y (NPY) is a cotransmitter with noradrenaline in guinea pig inferior mesenteric vein. Norepinephrine 45-58 pro-neuropeptide Y Cavia porcellus 0-14 10959006-1 2000 Neuropeptide Y (NPY) is a cotransmitter with noradrenaline in guinea pig inferior mesenteric vein. Norepinephrine 45-58 pro-neuropeptide Y Cavia porcellus 16-19 10959006-5 2000 Norepinephrine and NPY are involved in neuromuscular transmission in guinea pig mesenteric vein suggesting that the sympathetic nervous system requires the coordinated action of norepinephrine and NPY to serve capacitance. Norepinephrine 0-14 pro-neuropeptide Y Cavia porcellus 197-200 10959006-5 2000 Norepinephrine and NPY are involved in neuromuscular transmission in guinea pig mesenteric vein suggesting that the sympathetic nervous system requires the coordinated action of norepinephrine and NPY to serve capacitance. Norepinephrine 178-192 pro-neuropeptide Y Cavia porcellus 19-22 10827134-9 2000 Surprisingly, norepinephrine activates p38-MAPK via beta-ARs in mouse cardiomyocytes, but beta-AR activation of p38-MAPK alone is not sufficient to induce cardiomyocyte hypertrophy. Norepinephrine 14-28 adrenergic receptor, beta 1 Mus musculus 52-59 10737636-9 2000 These studies revealed that both CRLR and L1 were expressed only in cells that did not express PNMT, suggesting that adrenomedullin receptors are only found in noradrenaline-secreting cells. Norepinephrine 160-173 adrenomedullin Rattus norvegicus 117-131 10734146-6 2000 Both the alpha(2A)- and alpha(2C)-subtypes are important in the presynaptic inhibition of norepinephrine release and appear to have distinct regulatory roles. Norepinephrine 90-104 adrenergic receptor, alpha 2c Mus musculus 24-32 10729318-6 2000 In the presence of NPY concentration-response curves for acetylcholine and noradrenaline were significantly shifted to the right and left respectively. Norepinephrine 75-88 pro-neuropeptide Y Cavia porcellus 19-22 10729318-8 2000 The receptor reserve (K(A)/EC(50)) for acetylcholine was decreased and for noradrenaline was increased in the presence of NPY, although no changes in the dissociation constants of the neurotransmitter-receptor complexes were observed. Norepinephrine 75-88 pro-neuropeptide Y Cavia porcellus 122-125 10698191-5 2000 CRH KO mice had significantly lower plasma epinephrine and higher norepinephrine than WT mice at baseline, and delayed epinephrine secretion during restraint. Norepinephrine 66-80 corticotropin releasing hormone Mus musculus 0-3 10762326-2 2000 This rhythm involves the transcriptional regulation of the AANAT by two norepinephrine (NE)-inducible transcription factors, e.g. the activator pCREB (phosphorylated Ca2+/cAMP-response element binding protein) and the inhibitor ICER (inducible cAMP early repressor). Norepinephrine 72-86 cAMP responsive element modulator Mus musculus 228-232 10762326-2 2000 This rhythm involves the transcriptional regulation of the AANAT by two norepinephrine (NE)-inducible transcription factors, e.g. the activator pCREB (phosphorylated Ca2+/cAMP-response element binding protein) and the inhibitor ICER (inducible cAMP early repressor). Norepinephrine 72-86 cAMP responsive element modulator Mus musculus 234-264 10646533-0 2000 An investigation of noradrenaline uptake and release by the CATH.a cell line. Norepinephrine 20-33 cathepsin H Mus musculus 60-64 10652114-3 2000 NPY produced a concentration-dependent inhibition in fast ESP amplitude in the majority of neurones (17/21) with a calculated IC50 value of 7 nM; in some neurones this inhibition was mediated via the local release of noradrenaline. Norepinephrine 217-230 pro-neuropeptide Y Cavia porcellus 0-3 10773546-7 2000 Using LLC-PK(1) cells specifically expressing the individual transporter (i.e. dopamine [DAT], norepinephrine [NET], and SERT, respectively), ODAM showed a strong inhibition on SERT (K(i) = 0.12 +/- 0.02 nM). Norepinephrine 95-109 odontogenic, ameloblast associated Rattus norvegicus 142-146 10662890-0 2000 Protein kinase C-dependent inhibition of K+ currents in noradrenaline-induced depolarization of smooth muscle of guinea-pig vas deferens. Norepinephrine 56-69 Prkca Cavia porcellus 0-16 10714892-6 2000 In the functional study, concentration-response curves to noradrenaline pretreated with KMD-3213, an alpha1A/L-adrenoceptor selective antagonist, seemed to be biphasic in nature. Norepinephrine 58-71 calcium voltage-gated channel subunit alpha1 A Homo sapiens 101-108 11452226-5 2000 RESULTS: We found that 1) noradrenaline, 10-5 M, 10-6 M, and 10-7 M, significantly suppressed the production of IFNgamma and that noradrenaline, 10-5 M, significantly enhanced the production of IL-10. Norepinephrine 26-39 interleukin 10 Homo sapiens 194-199 11452226-5 2000 RESULTS: We found that 1) noradrenaline, 10-5 M, 10-6 M, and 10-7 M, significantly suppressed the production of IFNgamma and that noradrenaline, 10-5 M, significantly enhanced the production of IL-10. Norepinephrine 130-143 interleukin 10 Homo sapiens 194-199 11452226-7 2000 Noradrenaline, 10-5 M and 10-6 M, and clonidine, 10-5 M, significantly suppressed the IFNgamma/IL-10 production ratio. Norepinephrine 0-13 interleukin 10 Homo sapiens 95-100 10570042-3 1999 Recently, we demonstrated that platelet-derived growth factor (PDGF)-beta receptor stimulation, but not various other growth factors, inhibits transcription of alpha1D-, but not alpha1A- or alpha1B-ARs, resulting in reduced norepinephrine-mediated SMC growth. Norepinephrine 224-238 platelet derived growth factor subunit B Rattus norvegicus 63-73 10647009-6 1999 Both low- and high-frequency regulation seem to be physiologically important, as mice lacking both alpha2A- and alpha2C-receptor subtypes have elevated plasma noradrenaline concentrations and develop cardiac hypertrophy with decreased left ventricular contractility by four months of age. Norepinephrine 159-172 adrenergic receptor, alpha 2c Mus musculus 112-119 10543947-3 1999 SULT1A3 specifically sulfonates catecholamines such as dopamine, adrenaline and noradrenaline. Norepinephrine 80-93 sulfotransferase family 1A member 3 Homo sapiens 0-7 10385678-1 1999 The recently identified transport proteins organic cation transporter 1 (OCT1), OCT2, and extraneuronal monoamine transporter (EMT) accept dopamine, noradrenaline, adrenaline, and 5-hydroxytryptamine as substrates and hence qualify as non-neuronal monoamine transporters. Norepinephrine 149-162 POU class 2 homeobox 2 Homo sapiens 80-84 10385678-1 1999 The recently identified transport proteins organic cation transporter 1 (OCT1), OCT2, and extraneuronal monoamine transporter (EMT) accept dopamine, noradrenaline, adrenaline, and 5-hydroxytryptamine as substrates and hence qualify as non-neuronal monoamine transporters. Norepinephrine 149-162 solute carrier family 22 member 3 Homo sapiens 90-125 10385678-1 1999 The recently identified transport proteins organic cation transporter 1 (OCT1), OCT2, and extraneuronal monoamine transporter (EMT) accept dopamine, noradrenaline, adrenaline, and 5-hydroxytryptamine as substrates and hence qualify as non-neuronal monoamine transporters. Norepinephrine 149-162 solute carrier family 22 member 3 Homo sapiens 127-130 10336518-7 1999 Both norepinephrine and dopamine inhibited forskolin-stimulated cAMP accumulation in intact NRK-alpha2C cells. Norepinephrine 5-19 adrenergic receptor, alpha 2c Mus musculus 96-103 10336518-10 1999 The endogenous activator of the striatal alpha2C adrenoceptor may be dopamine, as well as norepinephrine. Norepinephrine 90-104 adrenergic receptor, alpha 2c Mus musculus 41-61 10431757-0 1999 Cannabinoid CB1 receptor-mediated inhibition of NMDA- and kainate-stimulated noradrenaline and dopamine release in the brain. Norepinephrine 77-90 cannabinoid receptor 1 Rattus norvegicus 12-15 10431757-9 1999 In conclusion, activation of CB1 receptors inhibits the NMDA- and kainate-stimulated noradrenaline release in guinea-pig hippocampus and the NMDA-stimulated dopamine release in rat striatum. Norepinephrine 85-98 cannabinoid receptor 1 Rattus norvegicus 29-32 10360575-5 1999 Mutant ganglionic anlagen also fail to switch on the genes that encode two enzymes needed for the biosynthesis of the neurotransmitter noradrenaline, dopamine-beta-hydroxylase and tyrosine hydroxylase, demonstrating that Phox2b regulates the noradrenergic phenotype in vertebrates. Norepinephrine 135-148 paired-like homeobox 2b Mus musculus 221-227 10318661-8 1999 CONCLUSIONS: Evidence that salbutamol increased norepinephrine release from cardiac sympathetic nerves was provided by the observations that atenolol suppressed the salbutamol inotropic response, demonstrating that this response was mediated in part by beta1-receptors and that salbutamol also resulted in an increase in cardiac norepinephrine spillover. Norepinephrine 48-62 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 253-258 10318661-8 1999 CONCLUSIONS: Evidence that salbutamol increased norepinephrine release from cardiac sympathetic nerves was provided by the observations that atenolol suppressed the salbutamol inotropic response, demonstrating that this response was mediated in part by beta1-receptors and that salbutamol also resulted in an increase in cardiac norepinephrine spillover. Norepinephrine 329-343 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 253-258 10411311-2 1999 In the present study, the PKC isozymes expressed in rat pinealocytes and their regulation by norepinephrine (NE) were investigated. Norepinephrine 93-107 protein kinase C, alpha Rattus norvegicus 26-29 10219238-2 1999 Botulinum neurotoxin E inhibition of norepinephrine release in permeabilized PC12 cells can be rescued by adding a 65 aa C-terminal fragment of SNAP-25 (S25-C). Norepinephrine 37-51 synaptosome associated protein 25 Rattus norvegicus 144-151 10081906-5 1999 The affinity profile of these antagonists suggested that the noradrenaline-induced contractions in the human prostate and the mesenteric artery were mediated by the alpha1L-AR and alpha1B-AR, respectively. Norepinephrine 61-74 adrenoceptor alpha 1B Homo sapiens 180-190 10076858-2 1999 This study examines the influence of selective 5-HT, as well as norepinephrine, receptor antagonists on the stress-induced down-regulation of BDNF mRNA. Norepinephrine 64-78 brain-derived neurotrophic factor Rattus norvegicus 142-146 9930739-4 1999 GFRP mRNA expression was abundant in serotonin neurons of the dorsal raphe nucleus but was undetectable in dopamine neurons of the midbrain or norepinephrine neurons of the locus coeruleus. Norepinephrine 143-157 GTP cyclohydrolase I feedback regulator Rattus norvegicus 0-4 9892008-3 1999 Norepinephrine activated PI 3-kinase in cells expressing human alpha1A and alpha1B via pertussis toxin-insensitive G proteins; alpha1D-receptors did not detectably activate this kinase. Norepinephrine 0-14 calcium voltage-gated channel subunit alpha1 A Homo sapiens 63-70 10477081-6 1999 PACAP increased tyrosine hydroxylase and dopamine beta-hydroxylase activities, but slightly lowered phenylethanolamine N-methyltransferase activity, resulting in a preferential rise in norepinephrine over epinephrine. Norepinephrine 185-199 adenylate cyclase activating polypeptide 1 Bos taurus 0-5 9928183-2 1998 It is hypothesized that increased activity of the locus coeruleus (LC) neurons, the principal norepinephrine (NE)-containing cells in the brain, causes release of galanin (GAL) in the ventral tegmentum (VTA) from LC axon terminals in which GAL is colocalized with NE. Norepinephrine 94-108 galanin and GMAP prepropeptide Homo sapiens 163-170 9928183-2 1998 It is hypothesized that increased activity of the locus coeruleus (LC) neurons, the principal norepinephrine (NE)-containing cells in the brain, causes release of galanin (GAL) in the ventral tegmentum (VTA) from LC axon terminals in which GAL is colocalized with NE. Norepinephrine 94-108 galanin and GMAP prepropeptide Homo sapiens 172-175 9763629-4 1998 Application of the adrenocorticotropin (ACTH) secretagogue noradrenaline (NA; norepinephrine), triggered [Ca2+]i oscillation in corticotrophs via alpha-adrenergic receptors and the guanosine trisphosphate (GTP) binding protein-coupled phosphoinositide pathway. Norepinephrine 59-72 RAS like proto-oncogene B Rattus norvegicus 181-226 9763629-4 1998 Application of the adrenocorticotropin (ACTH) secretagogue noradrenaline (NA; norepinephrine), triggered [Ca2+]i oscillation in corticotrophs via alpha-adrenergic receptors and the guanosine trisphosphate (GTP) binding protein-coupled phosphoinositide pathway. Norepinephrine 78-92 RAS like proto-oncogene B Rattus norvegicus 181-226 9769330-5 1998 The negative inotropic effects of a beta3-adrenoceptor agonist, BRL 37344, and also of norepinephrine in the presence of alpha- and beta1-2-blockade were inhibited both by a nonspecific blocker of NO, methylene blue, and two NO synthase (NOS) inhibitors, L-N-monomethyl-arginine and L-nitroarginine-methyl ester. Norepinephrine 87-101 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 132-139 9826063-0 1998 Nociceptin inhibits noradrenaline release in the mouse brain cortex via presynaptic ORL1 receptors. Norepinephrine 20-33 opioid receptor-like 1 Mus musculus 84-88 9774489-0 1998 Role of endothelial-derived reactive oxygen species and nitric oxide in norepinephrine-induced rat aortic ring contractions. Norepinephrine 72-86 mediator complex subunit 28 Rattus norvegicus 8-27 9774489-1 1998 In the present investigation involvement of endothelial-derived reactive oxygen species (ROS) and their interaction with nitric oxide (NO), during norepinephrine (NE)-induced contraction of rat aortic rings was studied. Norepinephrine 147-161 mediator complex subunit 28 Rattus norvegicus 44-63 9792233-1 1998 We have previously reported that atrial natriuretic factor (ANF) increases neuronal uptake and endogenous content of norepinephrine (NE) and diminishes neuronal release, synthesis and turn-over of NE in rat hypothalamus and adrenal medulla. Norepinephrine 117-131 natriuretic peptide A Rattus norvegicus 33-58 9792233-1 1998 We have previously reported that atrial natriuretic factor (ANF) increases neuronal uptake and endogenous content of norepinephrine (NE) and diminishes neuronal release, synthesis and turn-over of NE in rat hypothalamus and adrenal medulla. Norepinephrine 117-131 natriuretic peptide A Rattus norvegicus 60-63 9687576-3 1998 In Xenopus laevis oocytes expressing hOCT2, electrogenic transport of norepinephrine, histamine, dopamine, serotonin, and the antiparkinsonian drugs memantine and amantadine was demonstrated by tracer influx, tracer efflux, electrical measurements, or a combination. Norepinephrine 70-84 POU class 2 homeobox 2 Homo sapiens 37-42 9655843-8 1998 3-Isobutyl-1-methylxanthine in rates of 0.6 to 1.3 mumol/ min attenuated the CNP-induced positive inotropic responses, when it potentiated the positive inotropic response to norepinephrine. Norepinephrine 174-188 natriuretic peptide C Canis lupus familiaris 77-80 9650827-3 1998 A 0.1-ml bolus of 1 nmol human adrenomedullin is a potent inhibitor of the pressor response to exogenous norepinephrine infusion in an ex vivo canine tibia perfusion model for a duration of at least 70 min (P < 0.005). Norepinephrine 105-119 adrenomedullin Homo sapiens 31-45 9466976-0 1998 Nitric oxide, atrial natriuretic peptide, and cyclic GMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts. Norepinephrine 97-111 5'-nucleotidase, cytosolic II Homo sapiens 53-56 9507151-6 1998 These results suggest that microsphere embolism-induced changes in noradrenaline release from nerve terminals are due to a failure in the process following phosphorylation of synapsin I. Norepinephrine 67-80 synapsin I Rattus norvegicus 175-185 9505862-0 1998 Increased plasma levels of adrenomedullin in patients with hypertrophic cardiomyopathy: its relation to endothelin-I, natriuretic peptides and noradrenaline. Norepinephrine 143-156 adrenomedullin Homo sapiens 27-41 9505862-16 1998 Our results indicate that adrenomedullin may play an important role to maintain haemodynamics in patients with hypertrophic cardiomyopathy, and its action may be related to endothelin-1 but independent of atrial natriuretic peptide, brain natriuretic peptide and noradrenaline. Norepinephrine 263-276 adrenomedullin Homo sapiens 26-40 9421421-1 1998 c-Fos/c-Jun dimers (activating protein-1 transcription factor) are involved in the modulatory actions of angiotensin II (Ang II) on brain norepinephrine neurons, effects mediated via Ang II type 1 (AT1) receptors. Norepinephrine 138-152 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-5 9686497-7 1998 Plasma adrenomedullin was correlated strongly with endothelin-1,2, atrial natriuretic peptide, and noradrenaline, and relatively weakly with left ventricular ejection fraction. Norepinephrine 99-112 adrenomedullin Homo sapiens 7-21 9769705-13 1998 Both serotonin, acting through 5-HT2C receptors, and norepinephrine, acting through beta 2 and/or beta 3 receptors, reduce food intake. Norepinephrine 53-67 hemoglobin, beta adult minor chain Mus musculus 84-104 9421306-11 1997 NPY, PYY and PYY(3-36) inhibited [3H]-noradrenaline release from preparations of epididymis (pIC50 values 7.9+/-0.7, 9.6+/-0.8 and 10.0+/-0.9, respectively, all n=6). Norepinephrine 38-51 pro-neuropeptide Y Cavia porcellus 0-3 9396553-7 1997 Upon induction of acidosis, pHi fell rapidly in the artery precontracted by norepinephrine or high KCl, and the depression of pHi was similar in the two groups. Norepinephrine 76-90 glucose-6-phosphate isomerase Oryctolagus cuniculus 28-31 9325342-4 1997 Both [125I]AZIK and [125I]TBZ-AIPP photoaffinity labeling of purified rVMAT2 were protectable by 10 microM tetrabenazine (TBZ), 10 microM 7-aminoketanserin, and 1 mM concentrations of the transporter substrates dopamine, norepinephrine, and serotonin. Norepinephrine 221-235 solute carrier family 18 member A2 Rattus norvegicus 70-76 9323082-5 1997 Norepinephrine infusion (2.8 mg x kg(-1) x d(-1)) produced a degree of hypertension and degree of HO-1 mRNA upregulation similar to those of Ang II infusion, which was again blocked by treatment with hydralazine (382+/-18% and 150+/-30% of the control level, respectively). Norepinephrine 0-14 heme oxygenase 1 Rattus norvegicus 98-102 9313925-2 1997 In this study we have compared the abilities of the enantiomers of the structural isomers of the phenolamines, octopamine and synephrine, and the catecholamines, noradrenaline and adrenaline, to couple selectively a human cloned alpha 2A-adrenoceptor, stably expressed in a Chinese hamster ovary (CHO) cell line, to G-protein linked second messenger pathways mediating an increase and a decrease in cyclic AMP production. Norepinephrine 162-175 adrenoceptor alpha 2A Homo sapiens 229-250 9276148-1 1997 We have previously reported that neuropeptide Y (NPY) inhibits responses induced by various agonists (noradrenaline, vasoactive intestinal peptide, substance P,5-hydroxytryptamine) in isolated guinea pig trachea. Norepinephrine 102-115 pro-neuropeptide Y Cavia porcellus 33-47 9276148-1 1997 We have previously reported that neuropeptide Y (NPY) inhibits responses induced by various agonists (noradrenaline, vasoactive intestinal peptide, substance P,5-hydroxytryptamine) in isolated guinea pig trachea. Norepinephrine 102-115 pro-neuropeptide Y Cavia porcellus 49-52 9205950-6 1997 Furthermore, both beta 1 and beta 2-adrenoceptors can mediate experimental arrhythmias in human cardiac preparations elicited by noradrenaline and adrenaline. Norepinephrine 129-142 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 18-24 9076657-3 1997 The naloxone-induced rise in norepinephrine release was attenuated by concomitant administration of a protein kinase inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine hydrochloride (H-7) or an NMDA receptor antagonist, (+)-5-methyl-10, 11-dihydro-5H-dibenzo[a,d]-cyclohepten-5, 10-imine hydrogen maleate (dizocilpine, MK-801) with morphine. Norepinephrine 29-43 KIT proto-oncogene receptor tyrosine kinase Rattus norvegicus 102-116 9812844-2 1997 10(-6) mol/L ADM could also ameliorate alteration of the hemorheology induced by 10(-5) mol/L norepinephrine (NE) or 10(-7) mol/L endothelin (ET). Norepinephrine 94-108 adrenomedullin Rattus norvegicus 13-16 9038983-2 1997 Contractile response to five concentrations (10(-8)-10(-7) M) of the beta 1-AR agonist norepinephrine (NE) plus prazosin (10(-6) M) was measured after a 60-s rest, i.e., rested-state contraction (RSC), and during steady-state contraction (SSC) stimulation at 0.5 Hz (23 degrees C). Norepinephrine 87-101 adrenergic receptor, beta 1 Mus musculus 69-78 9066089-3 1997 Recent investigations have demonstrated the presence of several subtypes of alpha 1-adrenoceptors (alpha(1A), alpha(1B), and alpha(1D)) in the human corpus cavernosum and also that the noradrenaline-induced contraction in this tissue is probably mediated by two or, possibly, three receptor subtypes. Norepinephrine 185-198 calcium voltage-gated channel subunit alpha1 A Homo sapiens 99-107 8947470-2 1996 The basal level of inositol phosphate generation in cells expressing the CAM alpha 1B-adrenergic receptor was greater than for the wild-type receptor, The addition of maximally effective concentrations of phenylephrine or noradrenaline resulted in substantially greater levels of inositol phosphate generation by the CAM alpha 1B-adrenergic receptor, although this receptor was expressed at lower steady-state levels than the wild-type receptor. Norepinephrine 222-235 adrenoceptor alpha 1B Homo sapiens 77-105 8947470-2 1996 The basal level of inositol phosphate generation in cells expressing the CAM alpha 1B-adrenergic receptor was greater than for the wild-type receptor, The addition of maximally effective concentrations of phenylephrine or noradrenaline resulted in substantially greater levels of inositol phosphate generation by the CAM alpha 1B-adrenergic receptor, although this receptor was expressed at lower steady-state levels than the wild-type receptor. Norepinephrine 222-235 adrenoceptor alpha 1B Homo sapiens 321-349 8903325-0 1996 Atrial natriuretic peptide regulation of noradrenaline release in the anterior hypothalamic area of spontaneously hypertensive rats. Norepinephrine 41-54 natriuretic peptide A Rattus norvegicus 0-26 8903325-2 1996 Atrial natriuretic peptide (ANP) can inhibit the release of noradrenaline, and ANP concentration is elevated in the AHA of SHR. Norepinephrine 60-73 natriuretic peptide A Rattus norvegicus 0-26 8903325-2 1996 Atrial natriuretic peptide (ANP) can inhibit the release of noradrenaline, and ANP concentration is elevated in the AHA of SHR. Norepinephrine 60-73 natriuretic peptide A Rattus norvegicus 28-31 8903325-3 1996 The present study tests the hypothesis that in SHR, local ANP inhibits noradrenaline release from nerve terminals in AHA. Norepinephrine 71-84 natriuretic peptide A Rattus norvegicus 58-61 8903325-5 1996 In SHR on the basal diet, microperfusion of exogenous ANP into the AHA elicited a dose-related decrease in the concentration of the major noradrenaline metabolite 3-methoxy-4-hydroxy-phenylglycol (MOPEG) in the AHA; this effect was attenuated in the other two groups. Norepinephrine 138-151 natriuretic peptide A Rattus norvegicus 54-57 8982139-5 1996 A 0.1 ml bolus injection of 10(-5) M adrenomedullin decreased the baseline perfusion pressure in a dose-dependent manner for a duration of 20 minutes and also attenuated the pressor response to exogenous norepinephrine injection for at least 10 minutes compared with the control study (p < 0.05) in the absence of vascular endothelium. Norepinephrine 204-218 adrenomedullin Homo sapiens 37-51 8982139-7 1996 In addition, the attenuation effect of human adrenomedullin on pressor responses to exogenous norepinephrine injection is independent of vascular endothelium. Norepinephrine 94-108 adrenomedullin Homo sapiens 45-59 8896816-10 1996 Concomitant with the changes nNOS gene expression in central sites, the plasma concentration of norepinephrine was significantly elevated in rats with heart failure compared to sham-operated control rats. Norepinephrine 96-110 nitric oxide synthase 1 Rattus norvegicus 29-33 25594617-0 2015 Noradrenaline enhances angiotensin II responses via p38 MAPK activation after hypoxia/re-oxygenation in renal interlobar arteries. Norepinephrine 0-13 mitogen-activated protein kinase 14 Mus musculus 52-55 25758202-5 2015 Betaine does this most likely by supporting the methylation of norepinephrine to form epinephrine by phenylethanolamine N-methyltransferase. Norepinephrine 63-77 phenylethanolamine N-methyltransferase Homo sapiens 101-139 25912576-0 2015 Norepinephrine attenuates CXCR4 expression and the corresponding invasion of MDA-MB-231 breast cancer cells via beta2-adrenergic receptors. Norepinephrine 0-14 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 112-117 25912576-11 2015 Finally, we found the specific beta2-adrenergic antagonist, ICI 118,551, eliminated the impact of norepinephrine on CXCR4 expression. Norepinephrine 98-112 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 31-36 25691620-7 2015 Furthermore, norepinephrine caused an increase in G1 arrest in norepinephrine-treated T-lymphocytes, and this was accompanied by a decrease in pro-growth cyclin D3, E1, and E2 mRNA expression. Norepinephrine 13-27 cyclin D3 Mus musculus 154-163 25691620-7 2015 Furthermore, norepinephrine caused an increase in G1 arrest in norepinephrine-treated T-lymphocytes, and this was accompanied by a decrease in pro-growth cyclin D3, E1, and E2 mRNA expression. Norepinephrine 13-27 skull morphology 2 Mus musculus 165-175 26054146-7 2015 The general condition, open-field experimental result and gastric ulcer index were observed; the western blotting method was applied to measure the expression of vanilloid receptor subtype 1 (VR1) in hypothalamus and gastric antral mucosal, and ELISA method was applied to test the expression of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in hippocampus. Norepinephrine 327-341 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 192-195 25799564-9 2015 It was observed that when alpha1B-adrenergic receptors were stimulated with noradrenaline, the receptors interacted with proteins present in early endosomes, such as the early endosomes antigen 1, Rab 5, Rab 4, and Rab 11 but not with late endosome markers, such as Rab 9 and Rab 7. Norepinephrine 76-89 RAB11A, member RAS oncogene family Homo sapiens 215-221 25176177-7 2015 Loss of SLC10A4 in mice resulted in reduced striatal serotonin, noradrenaline, and dopamine concentrations and a significantly higher dopamine turnover ratio. Norepinephrine 64-77 solute carrier family 10 (sodium/bile acid cotransporter family), member 4 Mus musculus 8-15 25890242-8 2015 The effects on neuromodulator temporal dynamics were sensitive to the Monoamine oxidase-A (MAO-A) antagonist clorgyline (for norepinephrine and serotonin) and the ACh-E inhibitor donepezil (for acetylcholine). Norepinephrine 125-139 monoamine oxidase A Mus musculus 91-96 25562714-5 2015 Furthermore, to clarify the role of angiotensin II type 2 receptors (AT2) in norepinephrine (NE) release and the blood pressure of rat model of stress-induced hypertension, we intraperitoneally administered the AT2 receptor antagonist PD123319 (AT2 receptor antagonist, 0.3mg/kg, i.p.) Norepinephrine 77-91 angiotensin II receptor, type 2 Rattus norvegicus 69-72 25451930-4 2015 Despite its hyperfunctionality, we found the Arg-389 variant of ADRB1 to be hyperphosphorylated upon continuous stimulation with norepinephrine compared with the Gly-389 variant. Norepinephrine 129-143 adrenoceptor beta 1 Homo sapiens 64-69 25557223-5 2015 The visceral and noradrenaline, unlike dopamine, responses were blocked by a CRF1 antagonist injected into the CeA. Norepinephrine 17-30 corticotropin releasing hormone receptor 1 Homo sapiens 77-81 25543537-8 2014 In addition, we detected increased norepinephrine in the circulation, and observed that GHS-R knockdown in brown adipocytes directly stimulates thermogenic activity, suggesting that GHS-R regulates thermogenesis via both central and peripheral mechanisms.Collectively, our studies demonstrate that ghrelin signaling is an important thermogenic regulator in aging. Norepinephrine 35-49 growth hormone secretagogue receptor Homo sapiens 182-187 24803315-0 2014 The stress-related hormone norepinephrine induced upregulation of Nix, contributing to ECM protein expression. Norepinephrine 27-41 BCL2 interacting protein 3 like Homo sapiens 66-69 25056351-12 2014 Both FAK inhibitors PF-573228 and Y-11 significantly inhibited norepinephrine- and phenylephrine-induced contractions. Norepinephrine 63-77 protein tyrosine kinase 2 Homo sapiens 5-8 25131562-8 2014 Triple-labeling immunocytochemistry revealed that alpha2A-AR and CB1R were localised to processes that contained dopamine-beta-hydroxylase, a marker of norepinephrine. Norepinephrine 152-166 adrenoceptor alpha 2A Rattus norvegicus 50-60 24535841-0 2014 Neuropeptide y attenuates stress-induced bone loss through suppression of noradrenaline circuits. Norepinephrine 74-87 neuropeptide Y Mus musculus 0-14 24535841-9 2014 Importantly, specific reintroduction of NPY solely in noradrenergic neurons of otherwise Npy-null mice blocks the increase in circulating noradrenaline and the stress-induced bone loss. Norepinephrine 138-151 neuropeptide Y Mus musculus 40-43 25149991-7 2014 CONCLUSIONS: LKP lowered MAP in norepinephrine-induced hypertension, probably via activation of AT2R. Norepinephrine 32-46 angiotensin II receptor, type 2 Rattus norvegicus 96-100 25187989-2 2014 In the current study we demonstrate that the noradrenalin analogue octopamine and the cholecystokinin (CCK) homologue Drosulfakinin (Dsk) function downstream of TfAP-2 and Tiwaz (Twz) to control the number of meals in adult flies. Norepinephrine 45-57 tiwaz Drosophila melanogaster 179-182 24929186-0 2014 Quercetin-3-O-glucuronide inhibits noradrenaline-promoted invasion of MDA-MB-231 human breast cancer cells by blocking beta2-adrenergic signaling. Norepinephrine 35-48 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 119-124 25071172-7 2014 Central PREP regulation of insulin and glucagon secretion appears to be mediated by the autonomic nervous system because Prep(gt/gt) mice have elevated sympathetic outflow and norepinephrine levels in the pancreas, and propranolol treatment reversed glucose intolerance in these mice. Norepinephrine 176-190 prolyl endopeptidase Mus musculus 8-12 25071172-7 2014 Central PREP regulation of insulin and glucagon secretion appears to be mediated by the autonomic nervous system because Prep(gt/gt) mice have elevated sympathetic outflow and norepinephrine levels in the pancreas, and propranolol treatment reversed glucose intolerance in these mice. Norepinephrine 176-190 prolyl endopeptidase Mus musculus 121-125 25353000-4 2014 In both DIO and RYGB settings, these changes in ghrelin levels were associated with altered ghrelin cell responsiveness to two key physiological modulators of ghrelin secretion - glucose and norepinephrine. Norepinephrine 191-205 ghrelin Mus musculus 48-55 25353000-4 2014 In both DIO and RYGB settings, these changes in ghrelin levels were associated with altered ghrelin cell responsiveness to two key physiological modulators of ghrelin secretion - glucose and norepinephrine. Norepinephrine 191-205 ghrelin Mus musculus 92-99 25353000-4 2014 In both DIO and RYGB settings, these changes in ghrelin levels were associated with altered ghrelin cell responsiveness to two key physiological modulators of ghrelin secretion - glucose and norepinephrine. Norepinephrine 191-205 ghrelin Mus musculus 92-99 25024212-8 2014 Norepinephrine-evoked ICa,L responses were decreased by inhibition of Ca(2+)/calmodulin-dependent kinase II (CaMKII) in myocytes from patients with SR, but not in those from patients with AF. Norepinephrine 0-14 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 70-107 25024212-8 2014 Norepinephrine-evoked ICa,L responses were decreased by inhibition of Ca(2+)/calmodulin-dependent kinase II (CaMKII) in myocytes from patients with SR, but not in those from patients with AF. Norepinephrine 0-14 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 109-115 24777411-3 2014 The result showed that, under normoxic conditions, Cl(Ca) inhibitors (NFA and IAA-94) significantly relaxed second pulmonary artery contracted by norepinephrine (P < 0.01), but merely had effects on KCl-induced second pulmonary artery contractions. Norepinephrine 146-160 chloride channel accessory 5 Rattus norvegicus 51-57 24118769-7 2014 Exposure of primary cultures of proximal tubular cells to noradrenaline increased brush border NHE3 abundance and activity which was blocked by prior exposure to prazosin, indicating it as an alpha1 -adrenoceptor-mediated mechanism. Norepinephrine 58-71 solute carrier family 9 member A3 Rattus norvegicus 95-99 23963743-6 2014 Norepinephrine and CL 316,243-mediated induction of PGC-1alpha were decreased in cultured epididymal adipose tissue from AMPK beta1(-/-) relative to WT mice. Norepinephrine 0-14 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 52-62 23963743-8 2014 CONCLUSIONS: Norepinephrine- and CL 316,243-mediated induction of PGC-1alpha and mitochondrial protein expression is regulated by AMPK in epididymal, but not inguinal adipose tissue. Norepinephrine 13-27 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 66-76 24354565-2 2014 Methylation of the meta-hydroxyl is much more common than that of the para-hydroxyl in many COMT substrates, such as dopamine and norepinephrine. Norepinephrine 130-144 catechol-O-methyltransferase Homo sapiens 92-96 23581564-2 2014 MAO-A contributes to heart failure progression via enhanced norepinephrine catabolism and oxidative stress. Norepinephrine 60-74 monoamine oxidase A Mus musculus 0-5 24058188-3 2014 ATP acting on LC P2 receptors influences the release of noradrenaline. Norepinephrine 56-69 lymphocyte cytosolic protein 2 Rattus norvegicus 14-19 23985701-0 2014 Inhibition of farnesyl pyrophosphate synthase prevents norepinephrine-induced fibrotic responses in vascular smooth muscle cells from spontaneously hypertensive rats. Norepinephrine 55-69 farnesyl diphosphate synthase Rattus norvegicus 14-45 24018397-1 2013 Phenylethanolamine N-methyltransferase (PNMT) catalyzes the conversion of norepinephrine (noradrenaline) to epinephrine (adrenaline) while, concomitantly, S-adenosyl-L-methionine (AdoMet) is converted to S-adenosyl-L-homocysteine. Norepinephrine 74-88 phenylethanolamine N-methyltransferase Homo sapiens 0-38 24018397-1 2013 Phenylethanolamine N-methyltransferase (PNMT) catalyzes the conversion of norepinephrine (noradrenaline) to epinephrine (adrenaline) while, concomitantly, S-adenosyl-L-methionine (AdoMet) is converted to S-adenosyl-L-homocysteine. Norepinephrine 74-88 phenylethanolamine N-methyltransferase Homo sapiens 40-44 24018397-1 2013 Phenylethanolamine N-methyltransferase (PNMT) catalyzes the conversion of norepinephrine (noradrenaline) to epinephrine (adrenaline) while, concomitantly, S-adenosyl-L-methionine (AdoMet) is converted to S-adenosyl-L-homocysteine. Norepinephrine 90-103 phenylethanolamine N-methyltransferase Homo sapiens 0-38 24018397-1 2013 Phenylethanolamine N-methyltransferase (PNMT) catalyzes the conversion of norepinephrine (noradrenaline) to epinephrine (adrenaline) while, concomitantly, S-adenosyl-L-methionine (AdoMet) is converted to S-adenosyl-L-homocysteine. Norepinephrine 90-103 phenylethanolamine N-methyltransferase Homo sapiens 40-44 24018397-3 2013 At various times the kinetic mechanism of PNMT has been reported to operate by a random mechanism, an ordered mechanism in which norepinephrine binds first, and an ordered mechanism in which AdoMet binds first. Norepinephrine 129-143 phenylethanolamine N-methyltransferase Homo sapiens 42-46 23993195-8 2013 Electrophysiological analysis showed that Galphao-mediated inhibition of calcium currents by norepinephrine tended to be lower in three of the four Galphao mutants. Norepinephrine 93-107 G protein subunit alpha o1 Homo sapiens 42-49 23993195-8 2013 Electrophysiological analysis showed that Galphao-mediated inhibition of calcium currents by norepinephrine tended to be lower in three of the four Galphao mutants. Norepinephrine 93-107 G protein subunit alpha o1 Homo sapiens 148-155 23926250-1 2013 Monoamine oxidase A (MAO-A), the catabolic enzyme of norepinephrine and serotonin, plays a critical role in emotional and social behavior. Norepinephrine 53-67 monoamine oxidase A Mus musculus 0-19 23926250-1 2013 Monoamine oxidase A (MAO-A), the catabolic enzyme of norepinephrine and serotonin, plays a critical role in emotional and social behavior. Norepinephrine 53-67 monoamine oxidase A Mus musculus 21-26 23772221-14 2013 In conclusion, peripheral alpha2CAR-stimulation or AT1R-inhibition restored failing alpha2AAR-mediated auto-inhibition of norepinephrine and epinephrine release and control of TPR in SHR. Norepinephrine 122-136 adrenoceptor alpha 2C Rattus norvegicus 26-35 23772221-14 2013 In conclusion, peripheral alpha2CAR-stimulation or AT1R-inhibition restored failing alpha2AAR-mediated auto-inhibition of norepinephrine and epinephrine release and control of TPR in SHR. Norepinephrine 122-136 angiotensin II receptor, type 1a Rattus norvegicus 51-55 23772221-14 2013 In conclusion, peripheral alpha2CAR-stimulation or AT1R-inhibition restored failing alpha2AAR-mediated auto-inhibition of norepinephrine and epinephrine release and control of TPR in SHR. Norepinephrine 122-136 adrenoceptor alpha 2A Rattus norvegicus 84-93 22382522-0 2013 Berberine inhibits norepinephrine-induced apoptosis in neonatal rat cardiomyocytes via inhibiting ROS-TNF-alpha-caspase signaling pathway. Norepinephrine 19-33 caspase 2 Rattus norvegicus 112-119 23573890-4 2013 The data provided in the present study, demonstrate the novel ultrastructural immunolocalization of both CgA and VMAT2 in protein bodies, supporting their involvement in somatodendritic storage and release of noradrenaline in human LC. Norepinephrine 209-222 solute carrier family 18 member A2 Homo sapiens 113-118 23280413-1 2013 Catechol-O-methyltransferase (COMT) catalyzes the methylation of catecholamines, including neurotransmitters like dopamine, epinephrine and norepinephrine, leading to their degradation. Norepinephrine 140-154 catechol-O-methyltransferase Homo sapiens 0-28 23280413-1 2013 Catechol-O-methyltransferase (COMT) catalyzes the methylation of catecholamines, including neurotransmitters like dopamine, epinephrine and norepinephrine, leading to their degradation. Norepinephrine 140-154 catechol-O-methyltransferase Homo sapiens 30-34 22738191-7 2013 As expected, Tg mice showed a significant decrease in the cardiac amounts of the MAO-A substrates serotonin and norepinephrine. Norepinephrine 112-126 monoamine oxidase A Mus musculus 81-86 22971542-1 2012 Monoamine oxidase A (MAO-A) is the key enzyme for the degradation of brain serotonin (5-hydroxytryptamine, 5-HT), norepinephrine (NE) and dopamine (DA). Norepinephrine 114-128 monoamine oxidase A Mus musculus 0-19 22971542-1 2012 Monoamine oxidase A (MAO-A) is the key enzyme for the degradation of brain serotonin (5-hydroxytryptamine, 5-HT), norepinephrine (NE) and dopamine (DA). Norepinephrine 114-128 monoamine oxidase A Mus musculus 21-26 24900562-1 2013 Herein, we describe the discovery of inhibitors of norepinephrine (NET) and dopamine (DAT) transporters with reduced activity relative to serotonin transporters (SERT). Norepinephrine 51-65 solute carrier family 6 member 3 Rattus norvegicus 86-89 22858378-0 2012 Transglutaminase-mediated transamidation of serotonin, dopamine and noradrenaline to fibronectin: evidence for a general mechanism of monoaminylation. Norepinephrine 68-81 transglutaminase 1 Homo sapiens 0-16 22858378-4 2012 Here we show that the catecholamines dopamine (DA) and noradrenaline (NA) inhibit serotonylation of fibronectin and that DA and NA themselves can be selectively transamidated into fibronectin by TGase. Norepinephrine 55-68 transglutaminase 1 Homo sapiens 195-200 22866043-4 2012 Limited evidence exists for positive effects of HAI on: reduction of stress-related parameters such as epinephrine and norepinephrine; improvement of immune system functioning and pain management; increased trustworthiness of and trust toward other persons; reduced aggression; enhanced empathy and improved learning. Norepinephrine 119-133 serine peptidase inhibitor, Kunitz type 1 Homo sapiens 48-51 22582116-3 2012 In cells perfused with Ca(2+)-free Krebs Ringer bicarbonate solution (KRBS), brief exposures to caffeine (30 mM) and norepinephrine (300 muM), which activate SR ryanodine and inositol trisphosphate receptors (RyR, IP(3)R), respectively, or 4% O(2) caused rapid transient increases in [Ca(2+)](i), indicating intracellular Ca(2+) release. Norepinephrine 117-131 ryanodine receptor 2 Rattus norvegicus 209-212 22988760-0 2012 [Involvement of calmodulin in realization of vasoconstrictive effects of serotonin and norepinephrin]. Norepinephrine 87-100 calmodulin 1 Rattus norvegicus 16-26 22465165-5 2012 Twenty min after leptin treatment, there were higher plasma concentrations of noradrenaline, but not adrenaline, in comparison with the saline-treated control group. Norepinephrine 78-91 leptin Rattus norvegicus 17-23 21392097-2 2012 In the present study, we investigated whether calcitonin ameliorates diminished blood flow and enhanced arterial contraction in response to noradrenaline in chronic constriction injury (CCI) of the sciatic nerve in rats. Norepinephrine 140-153 calcitonin-related polypeptide alpha Rattus norvegicus 46-56 22371491-3 2012 By utilizing the G protein-coupled receptor (GPCR) heteromer identification technology on the live cell-based bioluminescence resonance energy transfer (BRET) assay platform, our studies in human embryonic kidney 293 cells have identified norepinephrine-dependent beta-arrestin recruitment that was in turn dependent upon co-expression of alpha(1A)AR with CXCR2. Norepinephrine 239-253 C-X-C motif chemokine receptor 2 Homo sapiens 356-361 22371491-5 2012 This norepinephrine-dependent beta-arrestin recruitment was inhibited not only by the alpha(1)AR antagonist Terazosin but also by the CXCR2-specific allosteric inverse agonist SB265610. Norepinephrine 5-19 C-X-C motif chemokine receptor 2 Homo sapiens 134-139 22233932-4 2012 Summit metabolism ( V O2summit) and norepinephrine-induced thermogenesis ( V O2NST) were significantly lower in UCP-dta mice relative to wild-type mice regardless of temperature treatment, but both were significantly higher in cold relative to warm acclimated mice. Norepinephrine 36-50 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 112-115 22253419-7 2012 The induction of RBP4 gene expression by norepinephrine required intact PPAR-dependent pathways, as evidenced by impaired response of the RBP4 gene expression to norepinephrine in PPARalpha-null brown adipocytes or in the presence of inhibitors of PPARgamma and PPARalpha. Norepinephrine 41-55 peroxisome proliferator activated receptor gamma Mus musculus 248-257 22253419-11 2012 The induction of the RBP4 gene expression by norepinephrine in brown adipocytes is protein synthesis dependent and requires PPARgamma-coactivator-1-alpha, which acts as a norepinephine-induced coactivator of PPAR on the RBP4 gene. Norepinephrine 45-59 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 124-153 22226998-8 2012 KCNMA1 gene silencing increased SM sensitivity to norepinephrine while Ach-induced relaxation had decreased. Norepinephrine 50-64 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 0-6 23227251-0 2012 Antidepressant acts on astrocytes leading to an increase in the expression of neurotrophic/growth factors: differential regulation of FGF-2 by noradrenaline. Norepinephrine 143-156 fibroblast growth factor 2 Rattus norvegicus 134-139 23227251-7 2012 Noradrenaline (NA) is known to induce FGF-2 expression in astrocyte cultures, as with antidepressants. Norepinephrine 0-13 fibroblast growth factor 2 Rattus norvegicus 38-43 21832987-1 2011 Monoamine oxidase (MAO)-A is a key enzyme for the degradation of brain serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE). Norepinephrine 113-127 monoamine oxidase A Mus musculus 0-25 22101429-3 2011 Acting via the beta(3)-adrenergic receptors, noradrenaline induces lipolysis in white adipocytes, whereas it stimulates the expression of thermogenic genes, such as PPAR-gamma coactivator 1a (Ppargc1a), uncoupling protein 1 (Ucp1) and acyl-CoA synthetase long-chain family member 1 (Acsl1), in brown adipocytes. Norepinephrine 45-58 acyl-CoA synthetase long chain family member 1 Homo sapiens 235-281 22101429-3 2011 Acting via the beta(3)-adrenergic receptors, noradrenaline induces lipolysis in white adipocytes, whereas it stimulates the expression of thermogenic genes, such as PPAR-gamma coactivator 1a (Ppargc1a), uncoupling protein 1 (Ucp1) and acyl-CoA synthetase long-chain family member 1 (Acsl1), in brown adipocytes. Norepinephrine 45-58 acyl-CoA synthetase long chain family member 1 Homo sapiens 283-288 21846718-1 2011 Catechol-O-methyltransferase (COMT) is a key enzyme for inactivation and metabolism of catechols, including dopamine, norepinephrine, caffeine, and estrogens. Norepinephrine 118-132 catechol-O-methyltransferase Homo sapiens 0-28 21846718-1 2011 Catechol-O-methyltransferase (COMT) is a key enzyme for inactivation and metabolism of catechols, including dopamine, norepinephrine, caffeine, and estrogens. Norepinephrine 118-132 catechol-O-methyltransferase Homo sapiens 30-34 21442465-7 2011 The administration of desipramine, a specific inhibitor of noradrenaline reuptake, prevented the increase in Nur77-like immunoreactivity and mRNA induced by stress in rats subjected to repeated exposure to immobilization stress. Norepinephrine 59-72 nuclear receptor subfamily 4, group A, member 1 Rattus norvegicus 109-114 21795689-8 2011 In functional secretion assays, nicotine-evoked [(3)H]norepinephrine release from cells overexpressing Plg-R(KT) was markedly decreased (by 51 +- 2%, p < 0.001) when compared with control transfected cells, and antibody blockade increased [(3)H]norepinephrine release from non-transfected PC12 cells. Norepinephrine 53-68 plasminogen receptor with a C-terminal lysine Rattus norvegicus 103-112 21795689-8 2011 In functional secretion assays, nicotine-evoked [(3)H]norepinephrine release from cells overexpressing Plg-R(KT) was markedly decreased (by 51 +- 2%, p < 0.001) when compared with control transfected cells, and antibody blockade increased [(3)H]norepinephrine release from non-transfected PC12 cells. Norepinephrine 54-68 plasminogen receptor with a C-terminal lysine Rattus norvegicus 103-112 21521766-5 2011 Presynaptic injection of NT or AID peptide into SCGN synapses inhibited synaptic transmission and also attenuated noradrenaline-induced G protein modulation. Norepinephrine 114-127 activation induced cytidine deaminase Homo sapiens 31-34 21521766-6 2011 In isolated SCGNs, NT and AID peptides reduced whole-cell Ca2+ current amplitude, modified voltage dependence of Ca2+ channel activation and attenuated noradrenaline-induced G protein modulation. Norepinephrine 152-165 activation induced cytidine deaminase Homo sapiens 26-29 21199648-7 2011 The salt-sensitive hypertension in rodents with impaired gamma-MSH signaling appears due to stimulation of noradrenergic activity, since plasma noradrenaline is increased and the hypertension is rapidly corrected with infusion of the alpha-adrenoceptor antagonist phentolamine. Norepinephrine 144-157 pro-opiomelanocortin-alpha Mus musculus 57-66 21344643-2 2011 COMT involves in the degradation of dopamine and norepinephrin. Norepinephrine 49-62 catechol-O-methyltransferase Homo sapiens 0-4 21394088-0 2011 Activation of central angiotensin type 2 receptors suppresses norepinephrine excretion and blood pressure in conscious rats. Norepinephrine 62-76 angiotensin II receptor, type 2 Rattus norvegicus 22-50 26610136-3 2011 PNMT catalyzes the conversion of norepinephrine into epinephrine (adrenaline), and inhibitors of PNMT are of potential therapeutic importance in Alzheimer"s and Parkinson"s disease. Norepinephrine 33-47 phenylethanolamine N-methyltransferase Homo sapiens 0-4 26610136-3 2011 PNMT catalyzes the conversion of norepinephrine into epinephrine (adrenaline), and inhibitors of PNMT are of potential therapeutic importance in Alzheimer"s and Parkinson"s disease. Norepinephrine 33-47 phenylethanolamine N-methyltransferase Homo sapiens 97-101 21317437-5 2011 Norepinephrine, acting via beta-adrenergic, cAMP-mediated, mechanisms and subsequent activation of protein kinase A and p38 MAPK, induces FGF21 gene transcription and also FGF21 release in brown adipocytes. Norepinephrine 0-14 fibroblast growth factor 21 Rattus norvegicus 172-177 21113058-8 2011 Overexpression of TFAM and TFB2M blocked hydrogen peroxide- and norepinephrine-induced decreases in Serca2a mRNA levels. Norepinephrine 64-78 transcription factor A, mitochondrial Rattus norvegicus 18-22 21113058-8 2011 Overexpression of TFAM and TFB2M blocked hydrogen peroxide- and norepinephrine-induced decreases in Serca2a mRNA levels. Norepinephrine 64-78 transcription factor B2, mitochondrial Rattus norvegicus 27-32 21302344-2 2011 Well-characterized common functional polymorphisms in the genes MAOA, COMT, and 5HTTLPR each have predictable effects on the availability of the monoamine neurotransmitters dopamine, noradrenaline, and serotonin. Norepinephrine 183-196 catechol-O-methyltransferase Homo sapiens 70-74 20637710-10 2010 We also found that ephA4 increased basal release of norepinephrine from nerve terminals of isolated tail arteries. Norepinephrine 52-66 Eph receptor A4 Rattus norvegicus 19-24 21164545-9 2010 The protein expression of tyrosine hydroxylase (TH) increased in the hippocampus by FSM administration and it is suggested that FSM may change norepinephrine or dopamine signaling in the brain. Norepinephrine 143-157 tyrosine hydroxylase Rattus norvegicus 26-46 21164545-9 2010 The protein expression of tyrosine hydroxylase (TH) increased in the hippocampus by FSM administration and it is suggested that FSM may change norepinephrine or dopamine signaling in the brain. Norepinephrine 143-157 tyrosine hydroxylase Rattus norvegicus 48-50 20641662-0 2004 (+)-2-Hydroxy-3-isobutyl-9-(3-[(18)F]fluoropropoxy)-10-methoxy-1,2,3,4,6,7-hexahydro-11bH-benzo[a]quinolizine Vesicular monoamine transporter (VMAT2) is present in brain monoaminergic neurons and is responsible for collecting neurotransmitters (dopamine, norepinephrine, and serotonin) from the cytoplasm and storing them in vesicles for synaptic release (1). Norepinephrine 255-269 solute carrier family 18 member A2 Homo sapiens 143-148 20642456-2 2010 PNMT (phenylethanolamine N-methyltransferase) catalyses the final step in the biosynthesis of adrenaline, the conversion of noradrenaline (norepinephrine) to adrenaline by methylation. Norepinephrine 124-137 phenylethanolamine N-methyltransferase Homo sapiens 0-4 20642456-2 2010 PNMT (phenylethanolamine N-methyltransferase) catalyses the final step in the biosynthesis of adrenaline, the conversion of noradrenaline (norepinephrine) to adrenaline by methylation. Norepinephrine 124-137 phenylethanolamine N-methyltransferase Homo sapiens 6-44 20642456-2 2010 PNMT (phenylethanolamine N-methyltransferase) catalyses the final step in the biosynthesis of adrenaline, the conversion of noradrenaline (norepinephrine) to adrenaline by methylation. Norepinephrine 139-153 phenylethanolamine N-methyltransferase Homo sapiens 0-4 20642456-2 2010 PNMT (phenylethanolamine N-methyltransferase) catalyses the final step in the biosynthesis of adrenaline, the conversion of noradrenaline (norepinephrine) to adrenaline by methylation. Norepinephrine 139-153 phenylethanolamine N-methyltransferase Homo sapiens 6-44 20642456-10 2010 We synthesized five elaborated benzimidazole compounds and characterized their binding to PNMT, showing for the first time how this class of inhibitors interact with the noradrenaline-binding site. Norepinephrine 170-183 phenylethanolamine N-methyltransferase Homo sapiens 90-94 20510373-1 2010 The functional Val158Met polymorphism in the gene coding for the catechol-O-methyltransferase (COMT), the major enzyme degrading the catecholaminergic neurotransmitters dopamine, norepinephrine, and epinephrine, has been associated with differential reactivity in limbic and prefrontal brain areas in response to aversive stimuli. Norepinephrine 179-193 catechol-O-methyltransferase Homo sapiens 65-93 20510373-1 2010 The functional Val158Met polymorphism in the gene coding for the catechol-O-methyltransferase (COMT), the major enzyme degrading the catecholaminergic neurotransmitters dopamine, norepinephrine, and epinephrine, has been associated with differential reactivity in limbic and prefrontal brain areas in response to aversive stimuli. Norepinephrine 179-193 catechol-O-methyltransferase Homo sapiens 95-99 20713709-5 2010 Addition of norepinephrine or epinephrine to the culture medium stimulated ghrelin secretion, and this effect was blocked by atenolol, a selective beta(1)-adrenergic antagonist. Norepinephrine 12-26 ghrelin Mus musculus 75-82 19894083-1 2010 One of the limitations of non-selective monoamine oxidase (MAO) inhibitors as anti-depressant or anti-Parkinson drugs is their ability to potentiate the cardiovascular effect of oral tyramine, resulting from inhibition of systemic MAO-A and release of noradrenaline. Norepinephrine 252-265 monoamine oxidase A Rattus norvegicus 40-57 19894083-1 2010 One of the limitations of non-selective monoamine oxidase (MAO) inhibitors as anti-depressant or anti-Parkinson drugs is their ability to potentiate the cardiovascular effect of oral tyramine, resulting from inhibition of systemic MAO-A and release of noradrenaline. Norepinephrine 252-265 monoamine oxidase A Rattus norvegicus 59-62 20389021-3 2010 In an orthotopic mouse model of human ovarian cancer, restraint stress and the associated increases in norepinephrine and epinephrine protected the tumor cells from anoikis and promoted their growth by activating focal adhesion kinase (FAK). Norepinephrine 103-117 protein tyrosine kinase 2 Homo sapiens 213-234 20389021-3 2010 In an orthotopic mouse model of human ovarian cancer, restraint stress and the associated increases in norepinephrine and epinephrine protected the tumor cells from anoikis and promoted their growth by activating focal adhesion kinase (FAK). Norepinephrine 103-117 protein tyrosine kinase 2 Homo sapiens 236-239 20389021-6 2010 These data suggest that FAK modulation by stress hormones, especially norepinephrine and epinephrine, can contribute to tumor progression in patients with ovarian cancer and may point to potential new therapeutic targets for cancer management. Norepinephrine 70-84 protein tyrosine kinase 2 Homo sapiens 24-27 19931319-5 2010 Ghrelin administered intravenously suppressed noradrenaline release in the BAT of WT rats, but not in Tg rats. Norepinephrine 46-59 ghrelin and obestatin prepropeptide Rattus norvegicus 0-7 19931319-7 2010 As our previous study showed that peripheral ghrelin-induced noradrenaline release suppression in BAT is blocked by vagotomy, the present findings also suggest that vagal afferents transmit the peripheral ghrelin signal to the sympathetic nervous system innervating BAT. Norepinephrine 61-74 ghrelin and obestatin prepropeptide Rattus norvegicus 45-52 19931319-7 2010 As our previous study showed that peripheral ghrelin-induced noradrenaline release suppression in BAT is blocked by vagotomy, the present findings also suggest that vagal afferents transmit the peripheral ghrelin signal to the sympathetic nervous system innervating BAT. Norepinephrine 61-74 ghrelin and obestatin prepropeptide Rattus norvegicus 205-212 19910579-4 2010 METHODS AND RESULTS: We report that MAO-A activity is triggered in isolated neonatal and adult myocytes on stimulation with norepinephrine, followed by increase in cell size, reactive oxygen species production, and signs of maladaptive hypertrophy. Norepinephrine 124-138 monoamine oxidase A Mus musculus 36-41 19910579-6 2010 In mice with left ventricular dilation and pump failure attributable to pressure overload, norepinephrine catabolism by MAO-A is increased accompanied by exacerbated oxidative stress. Norepinephrine 91-105 monoamine oxidase A Mus musculus 120-125 20064241-0 2010 Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia. Norepinephrine 0-14 cytochrome c oxidase II, mitochondrial Rattus norvegicus 54-59 20064241-5 2010 In the present study, we investigate the role of norepinephrine on cyclooxygenase- (COX-)2 expression/synthesis and prostaglandin (PG)E2 production in rat primary microglia. Norepinephrine 49-63 cytochrome c oxidase II, mitochondrial Rattus norvegicus 84-90 20064241-6 2010 RESULTS: Interestingly, norepinephrine increased COX-2 mRNA, but not protein expression. Norepinephrine 24-38 cytochrome c oxidase II, mitochondrial Rattus norvegicus 49-54 20064241-7 2010 Norepinephrine strongly enhanced COX-2 expression and PGE2 production induced by lipopolysaccharide (LPS). Norepinephrine 0-14 cytochrome c oxidase II, mitochondrial Rattus norvegicus 33-38 20064241-9 2010 Furthermore, beta-adrenoreceptor antagonists blocked the enhancement of COX-2 levels induced by norepinephrine and beta-adrenoreceptor agonists. Norepinephrine 96-110 cytochrome c oxidase II, mitochondrial Rattus norvegicus 72-77 19880803-0 2010 An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure. Norepinephrine 55-69 adrenoceptor alpha 2C Homo sapiens 3-30 19724290-8 2010 Incidence of ICH and levels of oxidative stress and MMP-9 were greater in mice with acute hypertension produced by AngII than by norepinephrine. Norepinephrine 129-143 matrix metallopeptidase 9 Mus musculus 52-57 20150881-0 2010 Norepinephrine modulates the effect of neuropeptides in coeliac ganglion on ovarian hormones release: its relationship with ovarian nitric oxide and nerve growth factor. Norepinephrine 0-14 nerve growth factor Rattus norvegicus 149-168 19783781-0 2009 Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits. Norepinephrine 22-36 cytochrome c oxidase subunit II Oryctolagus cuniculus 45-50 19783781-10 2009 These observations suggest that the local induction of COX-2 during atherosclerosis decreased the sensitivity to norepinephrine and that COX-2 inhibitors may increase vascular reactivity at sites of atherosclerotic lesions. Norepinephrine 113-127 cytochrome c oxidase subunit II Oryctolagus cuniculus 55-60 19573018-7 2009 Transfection of shRNAs specific to Phox2a or Phox2b genes significantly reduced mRNA and protein levels of NET and DBH after shutdown of endogenous Phox2, which was accompanied by a decreased [(3)H]norepinephrine uptake. Norepinephrine 198-212 paired like homeobox 2A Homo sapiens 35-41 19570037-0 2009 Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity. Norepinephrine 49-62 phenylethanolamine N-methyltransferase Homo sapiens 101-105 19570037-3 2009 Here we report the crystal structures of six human PNMT complexes, including the first structure of the enzyme in complex with its physiological ligand R-noradrenaline. Norepinephrine 152-167 phenylethanolamine N-methyltransferase Homo sapiens 51-55 19570037-6 2009 The crystal structures illustrate the adaptability of the PNMT substrate binding site in accepting multi-fused ring systems, such as substituted norbornene, as well as noradrenochrome, the oxidation product of noradrenaline. Norepinephrine 210-223 phenylethanolamine N-methyltransferase Homo sapiens 58-62 19359422-3 2009 We tested the hypothesis that heterotypic chronic stress (HeCS) elevates the release of norepinephrine from the adrenal medulla, which enhances transcription of the gene-regulating expression of Ca(v)1.2 (L-type) channels in colonic circular smooth muscle cells, resulting in enhanced colonic motor function. Norepinephrine 88-102 immunoglobulin lambda variable 2-8 Homo sapiens 195-203 19351665-0 2009 Ghrelin suppresses noradrenaline release in the brown adipose tissue of rats. Norepinephrine 19-32 ghrelin and obestatin prepropeptide Rattus norvegicus 0-7 19351665-1 2009 To clarify the role of ghrelin in the regulatory mechanism of energy metabolism, we analyzed the effects of centrally and peripherally administered ghrelin on noradrenaline release in the brown adipose tissue (BAT) of rats using a microdialysis system. Norepinephrine 159-172 ghrelin and obestatin prepropeptide Rattus norvegicus 148-155 19351665-3 2009 administration of ghrelin at a dose of 500 pmol suppressed noradrenaline release in BAT, and microinjection of ghrelin (50 pmol) into the paraventricular nucleus (PVN) or arcuate nucleus (ARC) of the hypothalamus also suppressed noradrenaline release in BAT. Norepinephrine 59-72 ghrelin and obestatin prepropeptide Rattus norvegicus 18-25 18983636-1 2009 The aim of this study was to investigate the effect of low-intensity resistance exercise with slow lifting and lowering (LSL) on plasma endothelin-1 (ET-1) and noradrenalin concentrations in young healthy adults. Norepinephrine 160-172 LEPQTL1 Homo sapiens 121-124 18947427-2 2008 Polymorphisms of this gene are known to alter receptor function or expression, as are polymorphisms of the alpha 2C-adrenergic receptor, which regulates norepinephrine release from cardiac presynaptic nerves. Norepinephrine 153-167 adrenoceptor alpha 2C Homo sapiens 107-135 18628210-11 2008 The plasma epinephrine and norepinephrine levels in the beta3-Tg mice were significantly increased in the basal state, indicating enhanced sympathetic tone. Norepinephrine 27-41 calcium channel, voltage-dependent, beta 3 subunit Mus musculus 56-61 18516067-5 2008 KEY RESULTS: The potency of the alpha1A-adrenoceptor selective agonist A61603 (pEC50=7.79+/-0.04) was 158-fold greater than that for noradrenaline (pEC50=5.59+/-0.02). Norepinephrine 133-146 adrenoceptor alpha 1A Sus scrofa 32-39 18516067-7 2008 The alpha1D-adrenoceptor selective antagonist BMY7378 caused rightward shifts of the concentration-response curves to phenylephrine and noradrenaline, yielding low affinity estimates of 6.59+/-0.15 and 6.33+/-0.13, respectively. Norepinephrine 136-149 alpha-1D adrenergic receptor Sus scrofa 4-24 18516067-8 2008 Relatively high affinity estimates were obtained for the alpha1A-adrenoceptor selective antagonists, RS100329 (9.01+/-0.14 and 9.06+/-0.22 with phenylephrine and noradrenaline, respectively) and 5-methylurapidil (8.51+/-0.10 and 8.31+/-0.10, respectively). Norepinephrine 162-175 adrenoceptor alpha 1A Sus scrofa 57-64 18840973-2 2008 They include transporters for norepinephrine, dopamine and serotonin, which are encoded by the SLC6A2, SLC6A3, and SLC6A4 genes, respectivily. Norepinephrine 30-44 solute carrier family 6 member 4 Canis lupus familiaris 115-121 18670361-0 2008 Angiotensin II type 2 receptor-mediated inhibition of norepinephrine release in isolated rat hearts. Norepinephrine 54-68 angiotensin II receptor, type 2 Rattus norvegicus 0-30 18585703-3 2008 Evidences have demonstrated that berberine possesses central nervous system activities, particularly the ability to inhibit monoamine oxidase-A, an enzyme involved in the degradation of norepinephrine and serotonin (5-HT). Norepinephrine 186-200 monoamine oxidase A Mus musculus 124-143 18485637-0 2008 Evidence that geniposide abrogates norepinephrine-induced hypopigmentation by the activation of GLP-1R-dependent c-kit receptor signaling in melanocyte. Norepinephrine 35-49 glucagon like peptide 1 receptor Homo sapiens 96-102 18329096-2 2008 NPY containing neurons have a broad central distribution and are often colocalized with norepinephrine (NE). Norepinephrine 88-102 neuropeptide Y Mus musculus 0-3 18177483-0 2008 Chronic noradrenaline increases renal expression of NHE-3, NBC-1, BSC-1 and aquaporin-2. Norepinephrine 8-21 solute carrier family 9 member A3 Rattus norvegicus 52-57 18177483-11 2008 Noradrenaline did significantly, but modestly (less than twofold), increase aquaporin-1 in the inner stripe of the outer medulla. Norepinephrine 0-13 aquaporin 1 Rattus norvegicus 76-87 18177483-13 2008 We conclude that noradrenaline-induced increases in the expression of NHE-3, NBC-1, BSC-1 and aquaporin-2 are likely to play an important role in the regulation of salt and water transport by noradrenaline in the kidney and may explain, at least in part, the altered renal sodium and water handling associated with overactivation of the sympathetic system. Norepinephrine 17-30 solute carrier family 9 member A3 Rattus norvegicus 70-75 18258664-6 2008 The KCl-induced increase in TH expression was partly reduced in the presence of the nicotinic receptor antagonist hexamethonium (100 microm), of noradrenaline (1 microm) and of the alpha(2)-adrenoreceptor agonist clonidine (1 microm). Norepinephrine 145-158 tyrosine hydroxylase Rattus norvegicus 28-30 18256599-5 2008 The cyclical release of HSCs and expression of Cxcl12 are regulated by core genes of the molecular clock through circadian noradrenaline secretion by the sympathetic nervous system. Norepinephrine 123-136 chemokine (C-X-C motif) ligand 12 Mus musculus 47-53 18364034-0 2008 Matrix metalloproteinases MMP2 and MMP9 are upregulated by noradrenaline in the mouse neuroendocrine hypothalamus. Norepinephrine 59-72 matrix metallopeptidase 9 Mus musculus 35-39 18364034-5 2008 We investigated the possible regulation of the two gelatinases, MMP2 and MMP9, by noradrenaline (NA) in the mouse neuroendocrine hypothalamus. Norepinephrine 82-95 matrix metallopeptidase 9 Mus musculus 73-77 18023073-2 2008 The purpose of the present study was to determine whether the tyrosine hydroxylase (TH) val81met and catechol-O-methyltransferase (COMT) val158met polymorphisms are associated with the antidepressant effect of milnacipran, a serotonin/noradrenaline reuptake inhibitor. Norepinephrine 235-248 catechol-O-methyltransferase Homo sapiens 131-135 18024547-9 2008 Importantly, a 2-wk administration of ghrelin dramatically suppressed the MI-induced increase in heart rate and plasma norepinephrine concentration to the similar levels as in sham-operated controls. Norepinephrine 119-133 ghrelin and obestatin prepropeptide Rattus norvegicus 38-45 17975121-3 2008 METHODS AND RESULTS: Norepinephrine and epinephrine, added to aortic smooth muscle cells (ASMCs) in vitro, altered Per1, E4bp4, and dbp expression and altered the observed oscillations in clock gene expression. Norepinephrine 21-35 nuclear factor, interleukin 3, regulated Mus musculus 121-126 18060386-7 2008 In the LC, 1 mg/kg of Wf-516 dampened the inhibitory effect of the preferential 5-HT(2A) agonist DOI on norepinephrine (NE) neurons, indicating that Wf-516 is also a 5-HT(2A) receptor antagonist. Norepinephrine 104-118 5-hydroxytryptamine receptor 2A Rattus norvegicus 80-87 17766642-1 2007 Monoamines, such as serotonin, dopamine, and norepinephrine, are sequestered into synaptic vesicles by specific transporters (vesicular monoamine transporter-2; VMAT2) using energy from an electrochemical proton gradient across the vesicle membranes. Norepinephrine 45-59 solute carrier family 18 member A2 Homo sapiens 126-159 17766642-1 2007 Monoamines, such as serotonin, dopamine, and norepinephrine, are sequestered into synaptic vesicles by specific transporters (vesicular monoamine transporter-2; VMAT2) using energy from an electrochemical proton gradient across the vesicle membranes. Norepinephrine 45-59 solute carrier family 18 member A2 Homo sapiens 161-166 19300629-1 2007 A functional polymorphism of the gene coding for Catechol-O-methyltrasferase (COMT), an enzyme responsible for the degradation of the catecholamine dopamine (DA), epinephrine, and norepinephrine, is associated with cognitive deficits. Norepinephrine 180-194 catechol-O-methyltransferase Homo sapiens 49-76 19300629-1 2007 A functional polymorphism of the gene coding for Catechol-O-methyltrasferase (COMT), an enzyme responsible for the degradation of the catecholamine dopamine (DA), epinephrine, and norepinephrine, is associated with cognitive deficits. Norepinephrine 180-194 catechol-O-methyltransferase Homo sapiens 78-82 17689499-0 2007 Upregulation of sodium-dependent vitamin C transporter 2 expression in adrenals increases norepinephrine production and aggravates hyperlipidemia in mice with streptozotocin-induced diabetes. Norepinephrine 90-104 solute carrier family 23 (nucleobase transporters), member 2 Mus musculus 16-56 17689499-6 2007 Furthermore, increased AA incorporation into the diabetic adrenals by SVCT-2 led to increased plasma norepinephrine, triglyceride and free fatty acid levels in mice with STZ-induced diabetes. Norepinephrine 101-115 solute carrier family 23 (nucleobase transporters), member 2 Mus musculus 70-76 17689499-7 2007 Therefore, oversupplementation with AA could be deleterious in diabetic patients, because overexpression of adrenal SVCT-2 in diabetes could lead to excessive AA uptake, thus enhancing norepinephrine production and exacerbating some diabetic complications. Norepinephrine 185-199 solute carrier family 23 member 2 Homo sapiens 116-122 17689499-9 2007 These results suggest SVCT-2-mediated increases in AA uptake by the adrenals followed by excessive production of plasma norepinephrine may play a pivotal role in the development of diabetic complications. Norepinephrine 120-134 solute carrier family 23 (nucleobase transporters), member 2 Mus musculus 22-28 17827867-0 2007 Characterization of noradrenaline-induced increases in intracellular Ca2+ levels in Chinese hamster ovary cells stably expressing human alpha1A-adrenoceptor. Norepinephrine 20-33 adrenoceptor alpha 1A Homo sapiens 136-156 17827867-1 2007 The mechanism for noradrenaline (NA)-induced increases in intracellular Ca(2+) concentration ([Ca(2+)](i)) and physiological significance of Na(+) influx through receptor-operated channels (ROCs) and store-operated channels (SOCs) were studied in Chinese hamster ovary (CHO) cells stably expressing human alpha(1A)-adrenoceptor (alpha(1A)-AR). Norepinephrine 18-31 adrenoceptor alpha 1A Homo sapiens 305-327 17581215-2 2007 The effects of adenosine and ATP receptor agonists on the release of endogenous noradrenaline from electrically stimulated (2 Hz, 0.1 msec) rat prostate were examined in order to clarify the pharmacological properties of prejunctional receptors for adenosine and ATP on the adrenergic nerve varicosities in the prostate. Norepinephrine 80-93 purinergic receptor P2X 6 Rattus norvegicus 29-41 17581215-5 2007 Both adenosine and ATP receptor agonists (1 micromol/L) inhibited noradrenaline release and the relative order of inhibitory effect was N(6)-cyclopentyl-adenosine (CPA) > 5"-N-ethylcarboxamidoadenosine > 2-chloroadenosine > adenosine > 2-methylthio-ATP (2mSATP) > AMP > ATP. Norepinephrine 66-79 purinergic receptor P2X 6 Rattus norvegicus 19-31 17581215-7 2007 The adenosine receptor agonist CPA (1 nmol/L-1 micromol/L) and the ATP receptor agonist 2mSATP (100 nmol/L-100 micromol/L) inhibited the stimulation-induced release of noradrenaline in a concentration-dependent manner. Norepinephrine 168-181 purinergic receptor P2X 6 Rattus norvegicus 67-79 17502491-5 2007 Interestingly, norepinephrine-dependent blood pressure elevations were conserved in NOX1-deficient mice, demonstrating that, different from angiotensin II, it acts through NOX1-independent hypertensive mechanisms. Norepinephrine 15-29 NADPH oxidase 1 Mus musculus 84-88 17592033-0 2007 Estrogen inhibition of norepinephrine responsiveness is initiated at the plasma membrane of GnRH-producing GT1-7 cells. Norepinephrine 23-37 myosin, light polypeptide 4 Mus musculus 107-110 17383824-1 2007 The effect of neuropeptide Y (NPY), a co-transmitter with noradrenaline in peripheral sympathetic nerve fibers, on the osteoclastogenesis in mouse bone marrow cell cultures treated with isoprenaline, a beta-adrenergic receptor (beta-AR) agonist, was examined. Norepinephrine 58-71 neuropeptide Y Mus musculus 30-33 17547583-4 2007 The catechol-O-methyl transferase (COMT) gene is located on chromosome 22q11 and is involved in the metabolism of dopamine and norepinephrine. Norepinephrine 127-141 catechol-O-methyltransferase Homo sapiens 4-33 17547583-4 2007 The catechol-O-methyl transferase (COMT) gene is located on chromosome 22q11 and is involved in the metabolism of dopamine and norepinephrine. Norepinephrine 127-141 catechol-O-methyltransferase Homo sapiens 35-39 17234900-4 2007 TAAR1 activation by monoamines and amphetamine-related compounds was greatly enhanced by coexpression of dopamine, norepinephrine, or serotonin transporters, and the activation enhancement was blocked by monoamine transporter inhibitors. Norepinephrine 115-129 trace amine associated receptor 1 Macaca mulatta 0-5 17405690-9 2007 Mercury, cadmium, and other heavy metals inactivate COMT, which increases serum and urinary epinephrine, norepinephrine, and dopamine. Norepinephrine 105-119 catechol-O-methyltransferase Homo sapiens 52-56 17242297-8 2007 Both also reduced (P<0.05) cyclooxygenase-2 mRNA and protein expression in PVN, cerebrospinal fluid prostaglandin E2, and plasma norepinephrine. Norepinephrine 132-146 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 30-46 16897602-1 2007 Catechol-O-methyltransferase (COMT) gene is one of the candidate genes for schizophrenia because it codes an enzyme that participates in the metabolic inactivation of dopamine and noradrenaline and a limiting factor of dopamine metabolism in the prefrontal cortex. Norepinephrine 180-193 catechol-O-methyltransferase Homo sapiens 0-28 16897602-1 2007 Catechol-O-methyltransferase (COMT) gene is one of the candidate genes for schizophrenia because it codes an enzyme that participates in the metabolic inactivation of dopamine and noradrenaline and a limiting factor of dopamine metabolism in the prefrontal cortex. Norepinephrine 180-193 catechol-O-methyltransferase Homo sapiens 30-34 17207896-4 2007 The aim of the present study was to determine the interaction between NPY and IL-1beta in catecholamine (norepinephrine, NE and epinephrine, EP) release from mouse chromaffin cells in culture. Norepinephrine 105-119 neuropeptide Y Mus musculus 70-73 16962210-0 2006 Involvement of G-protein betagamma subunits on the influence of inhibitory alpha2-autoreceptors on the angiotensin AT1-receptor modulation of noradrenaline release in the rat vas deferens. Norepinephrine 142-155 angiotensin II receptor, type 1a Rattus norvegicus 115-118 16962210-7 2006 The results indicate that activation of AT1-receptors coupled to the PLC-PKC pathway enhances noradrenaline release, an effect that is markedly favoured by an ongoing activation of alpha2-autoreceptors. Norepinephrine 94-107 angiotensin II receptor, type 1a Rattus norvegicus 40-43 16982607-7 2006 Importantly, activation of endogenous cAMP-coupled beta-adrenergic receptors with norepinephrine stimulated the phosphorylation of FRAT1 at Ser188. Norepinephrine 82-96 frequently rearranged in advanced T-cell lymphomas 1 S homeolog Xenopus laevis 131-136 17079456-0 2006 Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells. Norepinephrine 0-14 matrix metallopeptidase 2 Homo sapiens 82-114 17079456-2 2006 The purpose of this study is to determine if the stress hormone norepi can influence the expression of MMP-2, MMP-9, and VEGF in nasopharyngeal carcinoma (NPC) tumors by using three NPC tumor cell lines. Norepinephrine 64-70 matrix metallopeptidase 2 Homo sapiens 103-108 16751253-6 2006 Likewise, a reduction in pressor responses to noradrenaline was observed in hypertensive rats treated with IGF-IR antisense compared with full mismatch-treated rats (E(max) was reduced to 60 +/- 6 mm Hg compared with 108 +/- 5 mm Hg, p < 0.01). Norepinephrine 46-59 insulin-like growth factor 1 receptor Rattus norvegicus 107-113 16828079-6 2006 A metalloproteinase inhibitor, an anti-heparin-binding-EGF-selective antibody, and a selective EGF-receptor kinase inhibitor blocked the alpha1B-adrenoceptor phosphorylation induced by noradrenaline or endothelin-1. Norepinephrine 185-198 epidermal growth factor like 1 Rattus norvegicus 55-58 16828079-6 2006 A metalloproteinase inhibitor, an anti-heparin-binding-EGF-selective antibody, and a selective EGF-receptor kinase inhibitor blocked the alpha1B-adrenoceptor phosphorylation induced by noradrenaline or endothelin-1. Norepinephrine 185-198 epidermal growth factor like 1 Rattus norvegicus 95-98 16828079-6 2006 A metalloproteinase inhibitor, an anti-heparin-binding-EGF-selective antibody, and a selective EGF-receptor kinase inhibitor blocked the alpha1B-adrenoceptor phosphorylation induced by noradrenaline or endothelin-1. Norepinephrine 185-198 adrenoceptor alpha 1B Rattus norvegicus 137-157 17102092-1 2006 Pheochromocytomas in multiple endocrine neoplasia type 2 (MEN-2) express phenylethanolamine N-methyltransferase (PNMT), the enzyme that catalyzes conversion of norepinephrine to epinephrine, whereas those in von Hippel-Lindau (VHL) syndrome do not. Norepinephrine 160-174 phenylethanolamine N-methyltransferase Homo sapiens 73-111 17102092-1 2006 Pheochromocytomas in multiple endocrine neoplasia type 2 (MEN-2) express phenylethanolamine N-methyltransferase (PNMT), the enzyme that catalyzes conversion of norepinephrine to epinephrine, whereas those in von Hippel-Lindau (VHL) syndrome do not. Norepinephrine 160-174 phenylethanolamine N-methyltransferase Homo sapiens 113-117 16611835-1 2006 We reported elsewhere that orexin neurons are directly hyperpolarized by noradrenaline (NA) and dopamine. Norepinephrine 73-86 hypocretin Mus musculus 27-33 16309934-10 2006 In hypertrophied NNVM induced by norepinephrine, SNAP-mediated peroxynitrite-dependent inhibition of DNA synthesis, ERK1/2 and p38 phosphorylation were significantly attenuated. Norepinephrine 33-47 mitogen activated protein kinase 3 Rattus norvegicus 116-122 16309934-10 2006 In hypertrophied NNVM induced by norepinephrine, SNAP-mediated peroxynitrite-dependent inhibition of DNA synthesis, ERK1/2 and p38 phosphorylation were significantly attenuated. Norepinephrine 33-47 mitogen activated protein kinase 14 Rattus norvegicus 127-130 16139986-2 2006 Noradrenaline (NA)-producing cells of the brain stem are involved in regulating GnRH cells and project to the preoptic area (POA) and bed nucleus of stria terminalis (BnST). Norepinephrine 0-13 gonadotropin releasing hormone 1 Homo sapiens 80-84 16564429-5 2006 Noradrenaline, a neurotransmitter believed to play an immunosupressive role in neuroinflammatory disorders, is catabolized by catechol-O-methyl transferase (COMT). Norepinephrine 0-13 catechol-O-methyltransferase Homo sapiens 126-155 16564429-5 2006 Noradrenaline, a neurotransmitter believed to play an immunosupressive role in neuroinflammatory disorders, is catabolized by catechol-O-methyl transferase (COMT). Norepinephrine 0-13 catechol-O-methyltransferase Homo sapiens 157-161 16458982-1 2006 OBJECTIVE: We analysed the effect of aldosterone on calcitonin gene-related peptide (CGRP) mediated vasodilation in noradrenaline precontracted endothelium denuded mesenteric arteries segments from Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) and the effect of aldosterone on calcitonin receptor-like receptor (CL receptor) and receptor activity modifying protein 1 (RAMP1) expression in endothelium-denuded mesenteric arteries from SHR rats. Norepinephrine 116-129 calcitonin-related polypeptide alpha Rattus norvegicus 52-83 16458982-1 2006 OBJECTIVE: We analysed the effect of aldosterone on calcitonin gene-related peptide (CGRP) mediated vasodilation in noradrenaline precontracted endothelium denuded mesenteric arteries segments from Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) and the effect of aldosterone on calcitonin receptor-like receptor (CL receptor) and receptor activity modifying protein 1 (RAMP1) expression in endothelium-denuded mesenteric arteries from SHR rats. Norepinephrine 116-129 calcitonin-related polypeptide alpha Rattus norvegicus 85-89 16380518-7 2006 As compared with saline, nerve growth factor refilled depleted cardiac norepinephrine stores and improved cardiac [3H]-norepinephrine uptake into isolated perfused hearts of transverse aortic constricted rats. Norepinephrine 119-133 nerve growth factor Rattus norvegicus 25-44 16380518-11 2006 In conclusion, nerve growth factor attenuates local cardiac sympathetic overdrive of hypertrophic hearts by improving cardiac norepinephrine reuptake and might represent a novel therapeutic principle in the treatment of heart failure. Norepinephrine 126-140 nerve growth factor Rattus norvegicus 15-34 16648777-1 2006 OBJECTIVES: The catechol-O-methyltransferase (COMT) is an enzyme involved in the metabolism of dopamine, adrenaline and noradrenaline. Norepinephrine 120-133 catechol-O-methyltransferase Homo sapiens 16-44 16648777-1 2006 OBJECTIVES: The catechol-O-methyltransferase (COMT) is an enzyme involved in the metabolism of dopamine, adrenaline and noradrenaline. Norepinephrine 120-133 catechol-O-methyltransferase Homo sapiens 46-50 16428474-12 2006 Norepinephrine also increased tumor cell expression of MMP-2 (P = 0.02 for both SKOV3 and EG cells) and MMP-9 (P = 0.01 and 0.04, respectively), and pharmacologic blockade of MMPs abrogated the effects of norepinephrine on tumor cell invasive potential. Norepinephrine 0-14 matrix metallopeptidase 2 Homo sapiens 55-60 16428474-12 2006 Norepinephrine also increased tumor cell expression of MMP-2 (P = 0.02 for both SKOV3 and EG cells) and MMP-9 (P = 0.01 and 0.04, respectively), and pharmacologic blockade of MMPs abrogated the effects of norepinephrine on tumor cell invasive potential. Norepinephrine 0-14 matrix metallopeptidase 2 Homo sapiens 175-179 16225854-2 2006 METHODS: The positive inotropic effects of noradrenaline (in the presence of the beta2-selective antagonist ICI118551) and adrenaline (in the presence of the beta1-selective antagonist CGP20712), mediated through beta1- and beta2-adrenoceptors, respectively, were investigated in atrial and ventricular trabeculae. Norepinephrine 43-56 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 81-86 16225854-2 2006 METHODS: The positive inotropic effects of noradrenaline (in the presence of the beta2-selective antagonist ICI118551) and adrenaline (in the presence of the beta1-selective antagonist CGP20712), mediated through beta1- and beta2-adrenoceptors, respectively, were investigated in atrial and ventricular trabeculae. Norepinephrine 43-56 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 224-229 16543734-6 2006 However, the visceral depot of women showed a higher maximal stimulation by noradrenaline than that of men, in accordance with higher beta1- and beta3-AR protein levels. Norepinephrine 76-89 adrenoceptor beta 1 Homo sapiens 134-153 17201629-5 2006 Knowledge about thermogenesis-induced weight loss produced by green tea"s epigallocatechin gallate and its ability to inhibit catechol-O-methyltransferase is important for health benefits and for prolonging the action of norepinephrine in the synaptic cleft. Norepinephrine 221-235 catechol-O-methyltransferase Homo sapiens 126-154 16506409-4 2006 This they do by acting on naturally expressed prejunctional neuronal CB1 receptors to inhibit release of the contractile neurotransmitters, noradrenaline and ATP, that is provoked by the electrical stimulation. Norepinephrine 140-153 cannabinoid receptor 1 (brain) Mus musculus 69-72 16479149-2 2006 The accessory beta(3) subunits of Ca(2+) channels (Ca(V)beta(3)) are preferentially associated with the alpha(1B) subunit to form N-type Ca(2+) channels, and are therefore expected to play a functional role in the stimulation-evoked release of noradrenaline. Norepinephrine 244-257 calcium channel, voltage-dependent, beta 3 subunit Mus musculus 51-63 17008773-3 2006 The endotoxin-induced increase in the EC(50) value of norepinephrine was decreased by phenylene-1,3-bis[ethane-2-isothiourea] dihydrobromide (1,3-PBIT), a selective inducible NO synthase inhibitor, and U0126, a selective inhibitor of ERK1/2 phosphorylation by MAPK kinase. Norepinephrine 54-68 mitogen activated protein kinase 3 Rattus norvegicus 234-240 16878403-1 2006 Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. Norepinephrine 108-122 catechol-O-methyltransferase Homo sapiens 0-28 16878403-1 2006 Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. Norepinephrine 108-122 catechol-O-methyltransferase Homo sapiens 30-34 16148610-11 2005 A potential interaction consists in a reduction of vascular noradrenaline sensitivity, which can be considered as a class effect of AT1 antagonists at high dosage. Norepinephrine 60-73 angiotensin II receptor, type 1a Rattus norvegicus 132-135 16156742-1 2005 The homeodomain protein Arix/Phox2a plays a role in the development and maintenance of the noradrenergic cell type by regulating the transcription of genes involved in the biosynthesis and metabolism of noradrenaline. Norepinephrine 203-216 paired like homeobox 2A Homo sapiens 24-28 16156742-1 2005 The homeodomain protein Arix/Phox2a plays a role in the development and maintenance of the noradrenergic cell type by regulating the transcription of genes involved in the biosynthesis and metabolism of noradrenaline. Norepinephrine 203-216 paired like homeobox 2A Homo sapiens 29-35 16195872-0 2005 Cannabinoid CB1 receptor-mediated inhibition of noradrenaline release in guinea-pig vessels, but not in rat and mouse aorta. Norepinephrine 48-61 cannabinoid receptor 1 (brain) Mus musculus 12-15 15701815-0 2005 Calmodulin mediates norepinephrine-induced receptor-operated calcium entry in preglomerular resistance arteries. Norepinephrine 20-34 calmodulin 1 Rattus norvegicus 0-10 16004579-7 2005 Intravenous infusion of verapamil (VE; 200 microg/kg/min), and norepinephrine (NE; 20 microg/mL/min) to maintain normal blood pressure, increased rCBF by 141.5% at the primary injury site when compared to untreated, FPinjured animals. Norepinephrine 63-77 CCAAT/enhancer binding protein zeta Rattus norvegicus 146-150 15927391-1 2005 Catechol-O-methyltransferase (COMT) inactivates dopamine, epinephrine and norepinephrine in the nervous system. Norepinephrine 74-88 catechol-O-methyltransferase Homo sapiens 0-28 15927391-1 2005 Catechol-O-methyltransferase (COMT) inactivates dopamine, epinephrine and norepinephrine in the nervous system. Norepinephrine 74-88 catechol-O-methyltransferase Homo sapiens 30-34 15956122-11 2005 The subjects carrying the beta2-polymorphisms linked to weight gain and BP elevation also have higher plasma norepinephrine levels that are present at entry before weight gain and BP elevation. Norepinephrine 109-123 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 26-31 15900225-1 2005 OBJECTIVES: Catechol-O-methyltransferase plays a central role in the metabolism of biogenic amines such as norepinephrine, dopamine and serotonin. Norepinephrine 107-121 catechol-O-methyltransferase Homo sapiens 12-40 15834289-1 2005 OBJECTIVE: To test the hypothesis that the enhanced vascular responsiveness to norepinephrine that occurs during deoxycorticosterone acetate (DOCA)-salt induced hypertension is causally related to increased expression of cyclo-oxygenase (COX)-2 and oxidative stress, which diminishes the vasomodulatory influence of endothelium-derived nitric oxide. Norepinephrine 79-93 cytochrome c oxidase II, mitochondrial Rattus norvegicus 221-244 15834289-10 2005 CONCLUSIONS: COX-2 expression increases during DOCA-salt hypertension, and mediates production of factors that enhance rat aortic contractility in response to norepinephrine. Norepinephrine 159-173 cytochrome c oxidase II, mitochondrial Rattus norvegicus 13-18 15834289-11 2005 Our data also suggest a role for increased oxidative stress, which is at least in part dependent on enhanced COX-2 expression, in the mechanism(s) of enhanced aortic contractility in response to norepinephrine during DOCA-salt hypertension. Norepinephrine 195-209 cytochrome c oxidase II, mitochondrial Rattus norvegicus 109-114 14871027-5 2003 Cyclooxygenase-1 inhibitors (flurbiprofen, 10(-7) M) attenuated the noradrenaline-induced contraction and cyclooxygenase-2 (nimesulide, 10(-7) M) slightly attenuated the contraction. Norepinephrine 68-81 prostaglandin-endoperoxide synthase 1 Rattus norvegicus 0-16 14871027-7 2003 Based on these results, it was suggested that the contraction induced by noradrenaline in the rat coronary artery in the presence of L-NAME and arachidonic acid is endothelium-dependent, and that it involves reactive oxygen species and endothelial cyclooxygenase-1 metabolites of arachidonic acid. Norepinephrine 73-86 prostaglandin-endoperoxide synthase 1 Rattus norvegicus 248-264 15314382-10 2003 CONCLUSION: The SP-6 acupressure reduced the subjective perception of dysmenorrhea and the levels of norepinephrine. Norepinephrine 101-115 Sp6 transcription factor Homo sapiens 16-20 14581168-1 2003 The contaminants in deionized and distilled water (DDI water) boiled with polystyrene resin inhibited A-type monoamine oxidase (MAO, MAO-A preferentially deaminates serotonin and norepinephrine and regulates these amines concentration) activity in monkey brain mitochondria. Norepinephrine 179-193 monoamine oxidase A Rattus norvegicus 128-131 14581168-1 2003 The contaminants in deionized and distilled water (DDI water) boiled with polystyrene resin inhibited A-type monoamine oxidase (MAO, MAO-A preferentially deaminates serotonin and norepinephrine and regulates these amines concentration) activity in monkey brain mitochondria. Norepinephrine 179-193 monoamine oxidase A Rattus norvegicus 133-138 14581168-7 2003 These results indicate that zinc benzoate, which inhibits MAO-A activity, is easily incorporated in DDI water by boiling polystyrene and also may be a contaminating environmental chemical compound that alters the levels of serotonin and norepinephrine in the central nervous system. Norepinephrine 237-251 monoamine oxidase A Rattus norvegicus 58-63 12855600-7 2003 CGRP (10(-10)--10(-7) M) produced a concentration-dependent relaxation of norepinephrine-induced contractions in both NP-DE and Day 18 pregnant rat uterine arteries. Norepinephrine 74-88 calcitonin-related polypeptide alpha Rattus norvegicus 0-4 12972630-1 2003 In rabbit portal vein myocytes noradrenaline activates a non-selective cation current (Icat) which involves a transient receptor potential protein (TRPC6). Norepinephrine 31-44 short transient receptor potential channel 6 Oryctolagus cuniculus 148-153 14727518-0 2003 [Possible involvement of IGF-1 receptor and IGF-binding protein in insulin-induced enhancement of noradrenaline response in diabetic rat aorta]. Norepinephrine 98-111 insulin-like growth factor 1 receptor Rattus norvegicus 25-39 14512028-9 2003 Our data suggest that HAND2 regulates cell type-specific expression of norepinephrine in concert with Phox2a by a novel mechanism. Norepinephrine 71-85 paired like homeobox 2A Homo sapiens 102-108 14520117-2 2003 Catechol-O-methyltransferase and monoamine oxidase enzymes are important agents in the metabolic inactivation of these neurotransmitters (ie, dopamine, serotonin, and norepinephrine). Norepinephrine 167-181 catechol-O-methyltransferase Homo sapiens 0-28 14500754-7 2003 Receptor function measured with the [3H]norepinephrine release assay was measurable in both nicotine-treated and NGF-treated cells; however, cytisine-stimulated [3H]norepinephrine release indicated that nicotine treatment increased an nAChR containing beta2 subunits, whereas NGF increased a receptor containing beta4 subunits. Norepinephrine 40-54 nerve growth factor Rattus norvegicus 113-116 12768272-4 2003 METHODS: The extracellular noradrenaline level within the CeA during naloxone-precipitated morphine withdrawal was measured using an in vivo microdialysis experiment on unanesthetized and freely moving rats. Norepinephrine 27-40 carcinoembryonic antigen gene family 4 Rattus norvegicus 58-61 12768272-6 2003 RESULTS: The extracellular noradrenaline level within the CeA was transiently elevated during morphine withdrawal. Norepinephrine 27-40 carcinoembryonic antigen gene family 4 Rattus norvegicus 58-61 12736159-1 2003 Norepinephrine stimulates lipolysis and concurrently inhibits insulin-stimulated leptin secretion from white adipocytes. Norepinephrine 0-14 leptin Rattus norvegicus 81-87 12736159-3 2003 Palmitic acid (1 mM) mimicked the inhibitory effects of norepinephrine (1 microM) on insulin (10 nM)-stimulated leptin secretion, but only at low albumin concentrations. Norepinephrine 56-70 leptin Rattus norvegicus 112-118 12736159-8 2003 These results demonstrate that long-chain fatty acids mimic the effects of norepinephrine on leptin secretion and suggest that they may play a regulatory role as messengers between stimulation of lipolysis by norepinephrine and inhibition of leptin secretion. Norepinephrine 75-89 leptin Rattus norvegicus 93-99 12972688-9 2003 These results also indicate the possibility that Zn ions may regulate physiologically the level of serotonin and norepinephrine content in brain by inhibiting a MAO-A activity. Norepinephrine 113-127 monoamine oxidase A Rattus norvegicus 161-166 12970076-0 2003 Lack of CB1 receptors increases noradrenaline release in vas deferens without affecting atrial noradrenaline release or cortical acetylcholine release. Norepinephrine 32-45 cannabinoid receptor 1 (brain) Mus musculus 8-11 12970107-0 2003 Possible involvement of IGF-1 receptor and IGF-binding protein in insulin-induced enhancement of noradrenaline response in diabetic rat aorta. Norepinephrine 97-110 insulin-like growth factor 1 receptor Rattus norvegicus 24-38 12858360-0 2003 Norepinephrine activates P44 and P42 MAPK in human prostate stromal and smooth muscle cells but not in epithelial cells. Norepinephrine 0-14 interferon induced protein 44 Homo sapiens 25-28 12878372-2 2003 This has been attributed to blockade of AT1 receptors located presynaptically on sympathetic nerve endings normally facilitating norepinephrine release. Norepinephrine 129-143 angiotensin II receptor type 1 Homo sapiens 40-43 12865312-4 2003 Norepinephrine caused a parallel increase in phosphorylated p42/44 MAPK (p42/44(MAPK)) and p90RSK that was reduced by prazosin or propranolol, indicating involvement of both alpha(1)- and beta-adrenergic receptors. Norepinephrine 0-14 mitogen activated protein kinase 1 Rattus norvegicus 60-71 12887689-0 2003 Noradrenaline induces expression of peroxisome proliferator activated receptor gamma (PPARgamma) in murine primary astrocytes and neurons. Norepinephrine 0-13 peroxisome proliferator activated receptor gamma Mus musculus 36-84 12887689-0 2003 Noradrenaline induces expression of peroxisome proliferator activated receptor gamma (PPARgamma) in murine primary astrocytes and neurons. Norepinephrine 0-13 peroxisome proliferator activated receptor gamma Mus musculus 86-95 12724349-7 2003 Norepinephrine also activates several transcriptional reporters through alpha1A-adrenergic receptors in PC12 cells, including reporters for activator protein 1, serum response element, cAMP response element, nuclear factor-kappaB, nuclear factor of activated T cells, gamma-interferon-activated sequence, and signal transducer and activator of transcription. Norepinephrine 0-14 Jun proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 140-159 12890778-1 2003 Thealpha2C subclass of adrenergic receptor (alpha2C-AR) mediates some of the antinociceptive actions of norepinephrine in the spinal cord. Norepinephrine 104-118 adrenoceptor alpha 2C Rattus norvegicus 44-54 12890395-4 2003 RESULTS: Plasma norepinephrine (NE) levels were significantly higher in patients with severe PIH than those in control subjects (P < 0.05). Norepinephrine 16-30 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 93-96 12817189-0 2003 Effects of angiotensin-(1-7) and other bioactive components of the renin-angiotensin system on vascular resistance and noradrenaline release in rat kidney. Norepinephrine 119-132 renin Rattus norvegicus 67-72 12871570-8 2003 Inhibition of brain MAO-A and -B by TV3326 resulted in significant elevations of dopamine, noradrenaline and serotonin in the striatum and hippocampus. Norepinephrine 91-104 monoamine oxidase A Rattus norvegicus 20-25 12906036-0 2003 Norepinephrine-induced inositol 1,4,5-trisphosphate formation in atrial myocytes is regulated by extracellular calcium, protein kinase C, and calmodulin. Norepinephrine 0-14 calmodulin 1 Rattus norvegicus 142-152 12749888-1 2003 Predominance in the urethra and prostate of the alpha(1A)-adrenoceptor subtype, which is believed to be the receptor mediating noradrenaline induced smooth muscle contraction in these tissues, led to the preparation of alpha(1A)-selective antagonists to be tested as uroselective compounds for the treatment of benign prostatic hyperplasia. Norepinephrine 127-140 adrenoceptor alpha 1A Canis lupus familiaris 48-70 12749888-1 2003 Predominance in the urethra and prostate of the alpha(1A)-adrenoceptor subtype, which is believed to be the receptor mediating noradrenaline induced smooth muscle contraction in these tissues, led to the preparation of alpha(1A)-selective antagonists to be tested as uroselective compounds for the treatment of benign prostatic hyperplasia. Norepinephrine 127-140 adrenoceptor alpha 1A Canis lupus familiaris 48-56 12746308-4 2003 Elevated nocturnal levels of Aa-nat mRNA were strongly suppressed following light exposure or adrenergic antagonist administration, demonstrating the involvement of norepinephrine in the stimulation of melatonin synthesis. Norepinephrine 165-179 serotonin N-acetyltransferase Mesocricetus auratus 29-35 12654529-5 2003 The suppressive influence of muscimol in the MPOA on GnRH release might be considered a net result of its direct inhibitory effect on GnRH release, indirect inhibitory influence on GnRH release through activation of the beta-endorphinergic system, and facilitation of GnRH neurons by increasing noradrenaline release. Norepinephrine 295-308 gonadotropin releasing hormone 1 Homo sapiens 53-57 12729939-1 2003 Angiotensin-converting enzyme (ACE) modulates dopamine turnover in the brain and catechol-O-methyltransferase (COMT) enzyme is an important agent in the metabolic inactivation of dopamine and norepinephrine. Norepinephrine 192-206 catechol-O-methyltransferase Homo sapiens 81-109 12729939-1 2003 Angiotensin-converting enzyme (ACE) modulates dopamine turnover in the brain and catechol-O-methyltransferase (COMT) enzyme is an important agent in the metabolic inactivation of dopamine and norepinephrine. Norepinephrine 192-206 catechol-O-methyltransferase Homo sapiens 111-115 12606673-0 2003 Norepinephrine evoked by potassium depolarization increases interstitial adenosine concentration via activation of ecto-5"-nucleotidase in rat hearts. Norepinephrine 0-14 5' nucleotidase, ecto Rattus norvegicus 115-135 28853928-8 2003 The reduced locomotor activity of Gdnf +/- mice was accompanied by reductions in NE transporter activity in the cerebellum and brain stem as well as decreased norepinephrine tissue levels in the LC. Norepinephrine 159-173 glial cell line derived neurotrophic factor Mus musculus 34-38 12609750-2 2003 Ang II stimulates norepinephrine (NE), epinephrine (EP) and NPY release from perifused chromaffin cells by 3-, 2- and 12-fold, respectively. Norepinephrine 18-32 angiogenin Homo sapiens 0-3 12646175-5 2003 The neurotransmitters, which were implicated in sleep/wake regulation, affected the activity of orexin neurons; noradrenaline and serotonin hyperpolarized, while carbachol depolarized orexin neurons in either the presence or absence of tetrodotoxin. Norepinephrine 112-125 hypocretin Mus musculus 96-102 12605405-1 2003 We studied the effects of serotonin and noradrenaline on the expression of arginine-vasopressin (AVP) and vasoactive intestinal peptide (VIP) in the suprachiasmatic nucleus (SCN). Norepinephrine 40-53 arginine vasopressin Mus musculus 75-95 12605405-1 2003 We studied the effects of serotonin and noradrenaline on the expression of arginine-vasopressin (AVP) and vasoactive intestinal peptide (VIP) in the suprachiasmatic nucleus (SCN). Norepinephrine 40-53 arginine vasopressin Mus musculus 97-100 12605405-2 2003 We used transgenic Tg8 mice knockout for the MAO-A (monoamine oxidase A) gene, which are characterized by increased amounts of serotonin and noradrenaline in brain compared to wild-type mice (C3H). Norepinephrine 141-154 monoamine oxidase A Mus musculus 45-50 12605405-2 2003 We used transgenic Tg8 mice knockout for the MAO-A (monoamine oxidase A) gene, which are characterized by increased amounts of serotonin and noradrenaline in brain compared to wild-type mice (C3H). Norepinephrine 141-154 monoamine oxidase A Mus musculus 52-71 12605405-5 2003 Inhibiting serotonin or noradrenaline synthesis in Tg8 mice by the administration of parachlorophenylalanine or alpha-methylparatyrosine, respectively, the amounts of AVP, VIP and their mRNAs were decreased, but not the number of peptidergic neurons. Norepinephrine 24-37 arginine vasopressin Mus musculus 167-170 12605405-6 2003 This study indicates that serotonin and noradrenaline stimulate AVP and VIP expression, and could participate in the differentiation of the neurochemical phenotype in the mouse SCN. Norepinephrine 40-53 arginine vasopressin Mus musculus 64-67 12618232-9 2003 CONCLUSION: These findings suggest that norepinephrine-induced hypertrophy is linked closely with p38 MAP kinase activation, which can be endogenously modulated through estrogen-responsive regulation of MKP-1 expression. Norepinephrine 40-54 mitogen-activated protein kinase 14 Mus musculus 98-101 12644001-0 2003 Hypoxia, angiotensin-II, and norepinephrine mediated apoptosis is stimulus specific in canine failed cardiomyocytes: a role for p38 MAPK, Fas-L and cyclin D1. Norepinephrine 29-43 Fas ligand Canis lupus familiaris 138-143 12644001-3 2003 AIMS: We tested the hypothesis that hypoxia (HX), angiotensin-II (A-II) and norepinephrine (NEPI) can mediate apoptosis by activating p38 MAPK, and thus initiating stimulus specific changes in Fas-L and cyclin D(1) expression in failing cardiomyocytes. Norepinephrine 76-90 Fas ligand Canis lupus familiaris 193-198 12578963-9 2003 Only noradrenaline resulted in a dose- and time-dependent induction of NF-kappaB and NF-kappaB-dependent gene expression, which depended on pertussis-toxin-sensitive G protein-mediated phosphophatidylinositol 3-kinase, Ras/Raf, and mitogen-activated protein kinase activation. Norepinephrine 5-18 zinc fingers and homeoboxes 2 Homo sapiens 223-226 12464610-3 2003 One such protein is a biogenic amine-binding protein (ABP) that binds serotonin, epinephrine, and norepinephrine. Norepinephrine 98-112 amine oxidase, copper containing 1 Rattus norvegicus 31-52 12464610-3 2003 One such protein is a biogenic amine-binding protein (ABP) that binds serotonin, epinephrine, and norepinephrine. Norepinephrine 98-112 amine oxidase, copper containing 1 Rattus norvegicus 54-57 12690638-5 2003 Since the CVS-induced modulation of CRH levels are consistent with an alteration of tyrosine hydroxylase levels in the locus coeruleus, CRH-norepinephrine (NE) interaction in the terminal projection of forebrain NE systems, PVN, BNST and CeA where NE stimulates CRII release, might contribute to the bi-directional change in CRH. Norepinephrine 140-154 carcinoembryonic antigen gene family 4 Rattus norvegicus 238-241 12524145-0 2003 Prostanoid EP3 and TP receptors-mediated inhibition of noradrenaline release from the isolated rat stomach. Norepinephrine 55-68 prostaglandin E receptor 3 Rattus norvegicus 11-14 12724950-0 2003 Thyrotropin releasing hormone (TRH) potentiates the metabolic effect of norepinephrine (NE) in warm-acclimated lean and obese rats. Norepinephrine 72-86 thyrotropin releasing hormone Rattus norvegicus 0-29 12724950-0 2003 Thyrotropin releasing hormone (TRH) potentiates the metabolic effect of norepinephrine (NE) in warm-acclimated lean and obese rats. Norepinephrine 72-86 thyrotropin releasing hormone Rattus norvegicus 31-34 12668889-1 2003 Human BNP serves to compensate for deteriorating cardiac function causing preload and afterload reductions, natriuresis, diuresis, suppression of the renin-angiotensin-aldosterone system (RAAS) and endothelin-1, and lowering of norepinephrine. Norepinephrine 228-242 natriuretic peptide B Homo sapiens 6-9 12797383-8 2003 The reduced locomotor activity of Gdnf+/- mice was accompanied by reductions in NE transporter activity in the cerebellum and brain stem as well as decreased norepinephrine tissue levels in the LC. Norepinephrine 158-172 glial cell line derived neurotrophic factor Mus musculus 34-38 12648529-4 2003 To elucidate whether G(h) mediates norepinephrine-stimulated intracellular signal transductions leading to activation of extracellular signal-regulated kinases (ERKs) and neonatal rat cardiomyocyte hypertrophy, we examined the effects of G(h) on the activation of ERKs and inhibitory effects of CRT on alpha(1)-adrenoceptor/G(h) signaling. Norepinephrine 35-49 mitogen activated protein kinase 3 Rattus norvegicus 161-165 12648529-5 2003 In neonatal rat cardiomyocytes, norepinephrine-induced ERKs activation was inhibited by an alpha(1)-adrenoceptor blocker (prazosin), but not by an beta-adrenoceptor blocker (propranolol). Norepinephrine 32-46 mitogen activated protein kinase 3 Rattus norvegicus 55-59 12648529-6 2003 Overexpression of the G(h) protein stimulated norepinephrine-induced ERKs activation, which was inhibited by alpha-adrenoceptor blocker (prazosin). Norepinephrine 46-60 mitogen activated protein kinase 3 Rattus norvegicus 69-73 12648529-7 2003 Co-overexpression of G(h) and CRT abolished norepinephrine-induced ERKs activation. Norepinephrine 44-58 calreticulin Rattus norvegicus 30-33 12648529-7 2003 Co-overexpression of G(h) and CRT abolished norepinephrine-induced ERKs activation. Norepinephrine 44-58 mitogen activated protein kinase 3 Rattus norvegicus 67-71 12648529-8 2003 Taken together, norepinephrine induces hypertrophy in neonatal rat cardiomyocytes through alpha(1)-AR stimulation and G(h) is partly involved in norepinephrine-induced MEK1,2/ERKs activation. Norepinephrine 145-159 mitogen activated protein kinase kinase 1 Rattus norvegicus 168-174 12648529-8 2003 Taken together, norepinephrine induces hypertrophy in neonatal rat cardiomyocytes through alpha(1)-AR stimulation and G(h) is partly involved in norepinephrine-induced MEK1,2/ERKs activation. Norepinephrine 145-159 mitogen activated protein kinase 3 Rattus norvegicus 175-179 12616336-1 2003 Two forms of the activated beta1-adrenoceptor exist, one that is stabilized by (-)-noradrenaline and is sensitive to blockade by (-)-propranolol and another which is stabilized by partial agonists such as (-)-pindolol and (-)-CGP 12177 but is relatively insensitive to (-)-propranolol. Norepinephrine 79-96 adrenoceptor beta 1 Homo sapiens 27-45 12450575-2 2002 We have found that cannabidiol can also interact with cannabinoid CB(1) receptor agonists in the mouse vas deferens, a tissue in which prejunctional cannabinoid CB(1) receptors mediate inhibition of electrically evoked contractions by suppressing noradrenaline and/or ATP release. Norepinephrine 247-260 cannabinoid receptor 1 (brain) Mus musculus 66-71 12450575-2 2002 We have found that cannabidiol can also interact with cannabinoid CB(1) receptor agonists in the mouse vas deferens, a tissue in which prejunctional cannabinoid CB(1) receptors mediate inhibition of electrically evoked contractions by suppressing noradrenaline and/or ATP release. Norepinephrine 247-260 cannabinoid receptor 1 (brain) Mus musculus 161-166 12446017-5 2002 A positive association between plasma norepinephrine levels and MMP-2 protein levels, and a negative correlation between plasma cortisol levels and MMP-2 levels were found. Norepinephrine 38-52 matrix metallopeptidase 2 Homo sapiens 64-69 12504920-3 2002 We hypothesized that norepinephrine (NE), acting on alpha(1) receptors in CeA, may modulate stress-induced anxiety-like behavioral responses and HPA activation. Norepinephrine 21-35 carcinoembryonic antigen gene family 4 Rattus norvegicus 74-77 14567072-4 2002 Treatment of the aorta from both control and castrated rats with the alpha 1B/alpha 1D-adrenoceptor alkylating agent chloroethylclonidine resulted in approximately 1600-fold rightward shift in the concentration-response curves to noradrenaline. Norepinephrine 230-243 adrenoceptor alpha 1D Rattus norvegicus 78-99 12564841-0 2002 Assay of catechol-O-methyltransferase activity in human erythrocytes using norepinephrine as a natural substrate. Norepinephrine 75-89 catechol-O-methyltransferase Homo sapiens 9-37 12421355-5 2002 In the neurochemical study, noradrenaline and O-phosphoserine were decreased in the midbrain of the saline-treated histidine decarboxylase gene knockout mice. Norepinephrine 28-41 histidine decarboxylase Mus musculus 115-138 12490007-7 2002 In parallel to elevating MABP and CPP, rCBF was significantly increased by norepinephrine and dopamine, being mostly pronounced with norepinephrine (+44% vs. +29%). Norepinephrine 75-89 CCAAT/enhancer binding protein zeta Rattus norvegicus 39-43 12235258-4 2002 alpha(1a)-AR activation by norepinephrine increased the cytosolic Ca(2+) concentration and phosphorylated ERK1/2 in a time- and concentration-dependent manner. Norepinephrine 27-41 mitogen-activated protein kinase 3 Mus musculus 106-112 12235258-8 2002 Norepinephrine-induced ERK1/2 phosphorylation was inhibited by the adenylyl cyclase activator forskolin and was enhanced by the adenylyl cyclase inhibitor 9-(tetrahydro-2-furanyl)-9H-purine-6-amine (SQ 22536) and the protein kinase A inhibitor 4-cyano-3-methylisoquinoline. Norepinephrine 0-14 mitogen-activated protein kinase 3 Mus musculus 23-29 12205187-10 2002 These data demonstrate that the VR1 receptor appears to be located presynaptically on afferents to the LC, and that activation of VR1 may serve to potentiate the release of glutamate and adrenaline/noradrenaline in this brain region. Norepinephrine 198-211 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 32-35 12205187-10 2002 These data demonstrate that the VR1 receptor appears to be located presynaptically on afferents to the LC, and that activation of VR1 may serve to potentiate the release of glutamate and adrenaline/noradrenaline in this brain region. Norepinephrine 198-211 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 130-133 12135946-1 2002 BACKGROUND: Whether catechol-O-methyltransferase (COMT), the enzyme that metabolizes extraneuronal norepinephrine, contributes to blood pressure regulation in humans is unknown. Norepinephrine 99-113 catechol-O-methyltransferase Homo sapiens 20-48 12135946-1 2002 BACKGROUND: Whether catechol-O-methyltransferase (COMT), the enzyme that metabolizes extraneuronal norepinephrine, contributes to blood pressure regulation in humans is unknown. Norepinephrine 99-113 catechol-O-methyltransferase Homo sapiens 50-54 12023879-3 2002 The lipolytic effect of noradrenaline was lowered by ectopic UCP1 in white adipocytes of aP2-Ucp1 transgenic mice, overexpressing the UCP1 gene from the aP2 gene promoter, reflecting the magnitude of UCP1 expression, the impaired stimulation of cAMP levels by noradrenaline and the reduction of the ATP/ADP ratio in different fat depots. Norepinephrine 24-37 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 61-65 12023879-3 2002 The lipolytic effect of noradrenaline was lowered by ectopic UCP1 in white adipocytes of aP2-Ucp1 transgenic mice, overexpressing the UCP1 gene from the aP2 gene promoter, reflecting the magnitude of UCP1 expression, the impaired stimulation of cAMP levels by noradrenaline and the reduction of the ATP/ADP ratio in different fat depots. Norepinephrine 24-37 transcription factor AP-2, alpha Mus musculus 89-92 12023879-3 2002 The lipolytic effect of noradrenaline was lowered by ectopic UCP1 in white adipocytes of aP2-Ucp1 transgenic mice, overexpressing the UCP1 gene from the aP2 gene promoter, reflecting the magnitude of UCP1 expression, the impaired stimulation of cAMP levels by noradrenaline and the reduction of the ATP/ADP ratio in different fat depots. Norepinephrine 24-37 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 93-97 12023879-3 2002 The lipolytic effect of noradrenaline was lowered by ectopic UCP1 in white adipocytes of aP2-Ucp1 transgenic mice, overexpressing the UCP1 gene from the aP2 gene promoter, reflecting the magnitude of UCP1 expression, the impaired stimulation of cAMP levels by noradrenaline and the reduction of the ATP/ADP ratio in different fat depots. Norepinephrine 24-37 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 134-138 12023879-3 2002 The lipolytic effect of noradrenaline was lowered by ectopic UCP1 in white adipocytes of aP2-Ucp1 transgenic mice, overexpressing the UCP1 gene from the aP2 gene promoter, reflecting the magnitude of UCP1 expression, the impaired stimulation of cAMP levels by noradrenaline and the reduction of the ATP/ADP ratio in different fat depots. Norepinephrine 24-37 transcription factor AP-2, alpha Mus musculus 153-156 12023879-3 2002 The lipolytic effect of noradrenaline was lowered by ectopic UCP1 in white adipocytes of aP2-Ucp1 transgenic mice, overexpressing the UCP1 gene from the aP2 gene promoter, reflecting the magnitude of UCP1 expression, the impaired stimulation of cAMP levels by noradrenaline and the reduction of the ATP/ADP ratio in different fat depots. Norepinephrine 24-37 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 134-138 12023879-3 2002 The lipolytic effect of noradrenaline was lowered by ectopic UCP1 in white adipocytes of aP2-Ucp1 transgenic mice, overexpressing the UCP1 gene from the aP2 gene promoter, reflecting the magnitude of UCP1 expression, the impaired stimulation of cAMP levels by noradrenaline and the reduction of the ATP/ADP ratio in different fat depots. Norepinephrine 260-273 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 61-65 12184062-5 2002 Eprosartan acts not only at vascular AT1 receptors but also at presynaptic AT1 receptors, causing inhibition of sympathetically stimulated noradrenaline release. Norepinephrine 139-152 angiotensin II receptor type 1 Homo sapiens 75-78 11959640-1 2002 Heart rate (HR) dynamics were investigated in mice deficient in monoamine oxidase A and B, whose phenotype includes elevated tissue levels of norepinephrine, serotonin, dopamine, and phenylethylamine. Norepinephrine 142-156 monoamine oxidase A Mus musculus 64-89 12028362-1 2002 Monoamine oxidase-A knockout (MAO-A KO) mice have elevated brain serotonin (5-HT) and noradrenaline (NA) levels, and one would therefore anticipate increased monoamine release and compensatory changes in other aspects of presynaptic monoamine function. Norepinephrine 86-99 monoamine oxidase A Mus musculus 0-19 11958827-1 2002 Phenylethanolamine N-methyltransferase (PNMT), the terminal enzyme of the catecholamine biosynthesis pathway, catalyzes the conversion of norepinephrine (NE) to epinephrine (EPI). Norepinephrine 138-152 phenylethanolamine N-methyltransferase Homo sapiens 0-38 11958827-1 2002 Phenylethanolamine N-methyltransferase (PNMT), the terminal enzyme of the catecholamine biosynthesis pathway, catalyzes the conversion of norepinephrine (NE) to epinephrine (EPI). Norepinephrine 138-152 phenylethanolamine N-methyltransferase Homo sapiens 40-44 11953080-1 2002 OBJECTIVE: To study the distribution and levels of norepinephrine (NE) and dopamine (DA) in placenta tissues of normal pregnancy and pregnancy induced hypertension syndrome (PIH) and discuss the relationship of NE and DA with PIH. Norepinephrine 51-65 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 174-177 11882582-8 2002 The abrogating effects of quercetin and OR486 on the metabolism and antimitogenic effects of 2-hydroxyestradiol were mimicked by 20 micromol/L norepinephrine and isoproterenol, substrates for COMT. Norepinephrine 143-157 catechol-O-methyltransferase Homo sapiens 192-196 11914123-7 2002 The Src kinase inhibitors PP1 and PP2 partially diminished the ERK responses elicited by both norepinephrine and PGF2alpha. Norepinephrine 94-108 neuropeptide Y receptor Y6 (pseudogene) Homo sapiens 34-37 11682453-13 2001 In conclusion, the present functional data in the mouse suggest that (1) alpha(1D)-like adrenoceptors are present in the mesenteric artery, (2) there is the regional difference for the sensitivity for noradrenaline in the abdominal aorta and (3) noradrenaline evokes the contraction mediated through alpha(1D)-adrenoceptor in the upper abdominal aorta, whereas there is alpha(1A)-adrenoceptor-mediated contraction in the lower abdominal aorta. Norepinephrine 201-214 adrenergic receptor, alpha 1d Mus musculus 300-322 11682453-13 2001 In conclusion, the present functional data in the mouse suggest that (1) alpha(1D)-like adrenoceptors are present in the mesenteric artery, (2) there is the regional difference for the sensitivity for noradrenaline in the abdominal aorta and (3) noradrenaline evokes the contraction mediated through alpha(1D)-adrenoceptor in the upper abdominal aorta, whereas there is alpha(1A)-adrenoceptor-mediated contraction in the lower abdominal aorta. Norepinephrine 201-214 adrenergic receptor, alpha 1a Mus musculus 370-392 11684074-1 2001 OBJECTIVE: In this study we have tested the hypothesis that degradation of collagen by matrix metalloproteinase 2 (MMP-2) precedes the deposition of extracellular matrix (ECM) after long term norepinephrine (NE) treatment. Norepinephrine 192-206 matrix metallopeptidase 2 Rattus norvegicus 87-113 11684074-1 2001 OBJECTIVE: In this study we have tested the hypothesis that degradation of collagen by matrix metalloproteinase 2 (MMP-2) precedes the deposition of extracellular matrix (ECM) after long term norepinephrine (NE) treatment. Norepinephrine 192-206 matrix metallopeptidase 2 Rattus norvegicus 115-120 11606427-3 2001 Of several genes that were regulated, we focused on macrophage migration inhibitory factor (MIF), which has been associated with the modulation of norepinephrine metabolism. Norepinephrine 147-161 macrophage migration inhibitory factor Rattus norvegicus 52-90 11774707-4 2001 The half-maximum effective concentration (EC50) of NAd was 1.7 x 10(-7) M, and the response was mimicked by an alpha 1-adrenoceptor agonist cirazoline and was inhibited by WB-4101, an alpha 1A-adrenoceptor antagonist. Norepinephrine 51-54 adrenoceptor alpha 1A Rattus norvegicus 184-205 11774707-5 2001 Oxymetazoline, a partial agonist for an alpha 1A-adrenoceptor, also evoked the inward current with an EC50 of 3.5 x 10(-8) M. The maximum current induced by oxymetazoline (10(-6) M) was 44% of that induced by NAd. Norepinephrine 209-212 adrenoceptor alpha 1A Rattus norvegicus 40-61 11677361-7 2001 Inhibition of ETA receptors by darusentan reversed aortic alterations produced by infusion of norepinephrine. Norepinephrine 94-108 endothelin receptor type A Rattus norvegicus 14-17 11677361-9 2001 CONCLUSIONS: Antagonism of ETA receptors effectively and rapidly reversed norepinephrine-induced aortic structural and compositional changes, suggesting a central role of endothelin in mediating this response. Norepinephrine 74-88 endothelin receptor type A Rattus norvegicus 27-30 11680172-1 2001 Using a microphysiometer with synchronized valve switching, we investigated real-time acid extrusion from CHO cells, in which human alpha-1a adrenoceptor (AR) is stably expressed, in response to noradrenaline (NA). Norepinephrine 195-208 adrenoceptor alpha 1A Homo sapiens 132-153 11701195-3 2001 Central administration of norepinephrine (NE) suppressed food intake with narcolepsy as GLP-1 in chicks. Norepinephrine 26-40 glucagon Gallus gallus 88-93 11591352-8 2001 The structure of PNMT shows that the inhibitor interacts with the enzyme in a different mode from the (modeled) substrate noradrenaline. Norepinephrine 122-135 phenylethanolamine N-methyltransferase Homo sapiens 17-21 11525314-3 2001 The objective of this study was to: (1) pharmacologically elucidate the alpha1-adrenoceptor subtype mediating norepinephrine-induced contraction of human isolated corpus cavernosal tissue and (2) conduct a clinical proof-of-concept study with Ro70-0004 to test the hypothesis that selective alpha1A-adrenoceptor blockade would improve erectile function in patients with MED. Norepinephrine 110-124 adrenoceptor alpha 1A Homo sapiens 291-311 11525314-5 2001 Prazosin, cyclazosin, RS-100329 and Ro70-0004/003 antagonized norepinephrine-induced contractile responses with affinity estimates (pK(B) or pA2) of 8.4, 7.3, 9.2 and 8.8, respectively, consistent with the singular involvement of alpha1A-adrenoceptor subtype. Norepinephrine 62-76 adrenoceptor alpha 1A Homo sapiens 230-250 11331416-8 2001 These results indicate that P2Y6 receptors mediate UTP-evoked noradrenaline release from rat sympathetic neurons via activation of protein kinase C, but not inhibition of K(M) channels. Norepinephrine 62-75 pyrimidinergic receptor P2Y6 Rattus norvegicus 28-32 11264240-2 2001 This study was designed to assess the molecular and cellular events involved in the up-regulation (and receptor supersensitivity) of brain alpha(2)-adrenoceptors as a result of chronic depletion of noradrenaline (and other monoamines) by reserpine. Norepinephrine 198-211 adrenoceptor alpha 2A Rattus norvegicus 139-161 11245920-2 2001 In the present study, we tested the hypothesis that inhibition of catecholamine metabolism with the MAO-A inhibitor, clorgyline, might enhance cocaine-induced increases in extracellular dopamine and norepinephrine in rat nucleus accumbens. Norepinephrine 199-213 monoamine oxidase A Rattus norvegicus 100-105 11239487-5 2001 Norepinephrine-induced thermogenesis in brown-fat cells is absolutely dependent on UCP1, as is the uncoupled state and the recoupling by purine nucleotides in isolated brown-fat mitochondria. Norepinephrine 0-14 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 83-87 11169504-5 2001 Results from double staining with antibodies to these subunits and to tyrosine hydroxylase, the enzyme that catalyzes the rate-limiting step in the biosynthesis of the sympathetic neurotransmitter norepinephrine, demonstrated that most neurons in the SCG express both the alpha7 and beta4 subunits. Norepinephrine 197-211 tyrosine hydroxylase Rattus norvegicus 70-90 11164826-1 2001 3,4-Dihydroxyphenylglycolaldehyde is the monoamine oxidase-A metabolite of two catecholamine neurotransmitters, epinephrine and norepinephrine. Norepinephrine 128-142 monoamine oxidase A Rattus norvegicus 41-60 11171057-1 2001 In rat-1 fibroblasts stably expressing rat alpha(1d)-adrenoceptors, noradrenaline and PMA markedly decreased alpha(1d)-adrenoceptor function (noradrenaline-elicited increases in calcium in whole cells and [(35)S]guanosine 5"-[gamma-thio]triphosphate binding in membranes), suggesting homologous and heterologous desensitizations. Norepinephrine 68-81 adrenoceptor alpha 1D Rattus norvegicus 43-65 11171057-1 2001 In rat-1 fibroblasts stably expressing rat alpha(1d)-adrenoceptors, noradrenaline and PMA markedly decreased alpha(1d)-adrenoceptor function (noradrenaline-elicited increases in calcium in whole cells and [(35)S]guanosine 5"-[gamma-thio]triphosphate binding in membranes), suggesting homologous and heterologous desensitizations. Norepinephrine 142-155 adrenoceptor alpha 1D Rattus norvegicus 43-65 11165376-2 2001 Nerve growth factor (NGF) decreased [3H]-norepinephrine (NE) uptake in association with a decrease in NET mRNA levels. Norepinephrine 41-55 nerve growth factor Rattus norvegicus 0-19 11165376-2 2001 Nerve growth factor (NGF) decreased [3H]-norepinephrine (NE) uptake in association with a decrease in NET mRNA levels. Norepinephrine 41-55 nerve growth factor Rattus norvegicus 21-24 11228103-3 2001 The functional results showed: (1) prazosin, the selective alpha1-AR antagonist, phentolamine, the alpha1- and alpha2-ARs antagonist, WB 4101 and 5-MU, the selective alpha1A-AR subtype antagonists were potent, competitive antagonists of noradrenaline (NA)-induced contraction (pA2 values of 11.03, 8.06, 9.02 and 8.34, respectively). Norepinephrine 237-250 adrenoceptor alpha 1A Homo sapiens 166-176 11123223-0 2001 ANG II potentiates mitogenic effect of norepinephrine in vascular muscle cells: role of FGF-2. Norepinephrine 39-53 angiogenin Homo sapiens 0-3 11244495-1 2001 Catechol-O-methyltransferase (COMT) is a major component of the metabolic pathways of neurotransmitters such as dopamine, adrenaline, and noradrenaline. Norepinephrine 138-151 catechol-O-methyltransferase Homo sapiens 0-28 11244495-1 2001 Catechol-O-methyltransferase (COMT) is a major component of the metabolic pathways of neurotransmitters such as dopamine, adrenaline, and noradrenaline. Norepinephrine 138-151 catechol-O-methyltransferase Homo sapiens 30-34 11191837-1 2001 We have tested the role of various protein kinases in noradrenaline-induced, alpha1A-adrenoceptor-mediated constriction of mesenteric and intrarenal rat microvessels. Norepinephrine 54-67 adrenoceptor alpha 1A Rattus norvegicus 77-97 11108260-1 2000 Stimulation with the endogenous neurotransmitter, norepinephrine (NE; a mixed alpha- and beta-adrenergic agonist), concentration dependently increased the phosphorylation of both p44 and p42 isoforms of MAPK. Norepinephrine 50-64 mitogen activated protein kinase 3 Rattus norvegicus 179-182 11108260-1 2000 Stimulation with the endogenous neurotransmitter, norepinephrine (NE; a mixed alpha- and beta-adrenergic agonist), concentration dependently increased the phosphorylation of both p44 and p42 isoforms of MAPK. Norepinephrine 50-64 mitogen activated protein kinase 3 Rattus norvegicus 203-207 11152280-2 2000 Cleavage of syntaxin and SNAP-25 by BoNT/C1 decreased in a dose-dependent way the release of both noradrenaline and adrenaline, but noradrenaline release was more sensitive to BoNT/C1. Norepinephrine 98-111 synaptosome associated protein 25 Bos taurus 25-32 11152280-2 2000 Cleavage of syntaxin and SNAP-25 by BoNT/C1 decreased in a dose-dependent way the release of both noradrenaline and adrenaline, but noradrenaline release was more sensitive to BoNT/C1. Norepinephrine 132-145 synaptosome associated protein 25 Bos taurus 25-32 11152280-3 2000 Cleavage of SNAP-25 by BoNT/A also had a larger inhibitory effect on noradrenaline release than on adrenaline release. Norepinephrine 69-82 synaptosome associated protein 25 Bos taurus 12-19 11229360-1 2000 Mice deficient in monoamine oxidase A (MAO A) have increased brain levels of serotonin (5-HT) and norepinephrine and show enhanced aggression. Norepinephrine 98-112 monoamine oxidase A Mus musculus 18-37 11229360-1 2000 Mice deficient in monoamine oxidase A (MAO A) have increased brain levels of serotonin (5-HT) and norepinephrine and show enhanced aggression. Norepinephrine 98-112 monoamine oxidase A Mus musculus 39-44 11033316-0 2000 Spatial, cellular and temporal basis of vasopressin potentiation of norepinephrine-induced cAMP formation. Norepinephrine 68-82 thymus, brain and testes associated Homo sapiens 0-7 10825155-5 2000 Ucp1(-/-) cells were as potent as wild-type in norepinephrine-induced cAMP accumulation and lipolysis and had a similar mitochondrial respiratory complement. Norepinephrine 47-61 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 0-4 10860763-3 2000 Norepinephrine (NE) induces a rise in diacylglycerol levels which is sustained for 24 h and is associated with the translocation (at 5 min) and down-regulation (at 24 h) of PKC delta and PKC xi (but not PKC alpha). Norepinephrine 0-14 protein kinase C delta Homo sapiens 173-193 10860763-6 2000 WB-4101 (alpha(1A/c)- and alpha(1D)-receptor antagonist) and 5-methylurapidil (alpha(1A/c)-receptor antagonist) inhibit norepinephrine-dependent accumulation of inositol phosphate and diacylglycerol, down-regulation of PKC delta and PKC xi, and activation of ERK. Norepinephrine 120-134 protein kinase C delta Homo sapiens 219-228 10898900-2 2000 The enzyme catechol-O-methyltransferase (COMT) plays a key role in the degradation of catecholamines such as dopamine, L-DOPA, adrenaline, and noradrenaline and therefore could be considered as a candidate locus for ADHD susceptibility. Norepinephrine 143-156 catechol-O-methyltransferase Homo sapiens 11-39 10898900-2 2000 The enzyme catechol-O-methyltransferase (COMT) plays a key role in the degradation of catecholamines such as dopamine, L-DOPA, adrenaline, and noradrenaline and therefore could be considered as a candidate locus for ADHD susceptibility. Norepinephrine 143-156 catechol-O-methyltransferase Homo sapiens 41-45 10997600-2 2000 Both serotonin, acting through 5HT1B/2C receptors, and norepinephrine acting through beta2 and/or beta3 receptors reduce food intake and augment sympathetic activity. Norepinephrine 55-69 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 85-90 10835639-7 2000 We show that Th and Dbh deficiencies lead to reduced noradrenaline in the SNS, and that noradrenaline deficiency is a proximal cause of death in mutants by feeding catechol intermediates to pregnant dams, thereby partially averting Gata3 mutation-induced lethality. Norepinephrine 53-66 tyrosine hydroxylase Mus musculus 13-15 10801302-4 2000 Plasma catecholamine concentrations significantly increased at 60 min after intracerebroventricular injection of leptin (control vs. 60 min; epinephrine: 33 +/- 12 vs. 97 +/- 27 pg/ml, P < 0.05; norepinephrine: 298 +/- 39 vs. 503 +/- 86 pg/ml, P < 0.05). Norepinephrine 198-212 leptin Oryctolagus cuniculus 113-119 10843184-5 2000 Only nocturnal urinary norepinephrine excretion could explain a significant fraction of the variability in both UCP2 and UCP3 expression in muscle, but not adipose tissue. Norepinephrine 23-37 uncoupling protein 2 Homo sapiens 112-116 10767058-7 2000 These results indicate that synapsin I plays a role in regulating noradrenaline release. Norepinephrine 66-79 synapsin I Mus musculus 28-38 10719089-2 2000 We examined by immunohistochemistry the effects of monoamine oxidase (MAO) inhibition on the content of dopamine (DA) and noradrenaline (NA) in locus coeruleus (LC) neurons of the rat. Norepinephrine 122-135 monoamine oxidase A Rattus norvegicus 51-68 10719089-2 2000 We examined by immunohistochemistry the effects of monoamine oxidase (MAO) inhibition on the content of dopamine (DA) and noradrenaline (NA) in locus coeruleus (LC) neurons of the rat. Norepinephrine 122-135 monoamine oxidase A Rattus norvegicus 70-73 10688593-2 2000 Consequently, norepinephrine (NE) accumulates in the axoplasm, because it is no longer stored in synaptic vesicles, and intraneuronal Na(+) concentration increases, as the Na(+)/H(+) exchanger (NHE) is activated. Norepinephrine 14-28 solute carrier family 9 member C1 Homo sapiens 172-192 10688593-2 2000 Consequently, norepinephrine (NE) accumulates in the axoplasm, because it is no longer stored in synaptic vesicles, and intraneuronal Na(+) concentration increases, as the Na(+)/H(+) exchanger (NHE) is activated. Norepinephrine 14-28 solute carrier family 9 member C1 Homo sapiens 194-197 10789691-13 2000 The data strongly suggest that AT1 receptors are involved in this interaction, since selective AT1 receptor blockade with losartan significantly reduced the angiotensin II induced norepinephrine concentration. Norepinephrine 180-194 angiotensin II receptor, type 1a Rattus norvegicus 31-34 10789691-13 2000 The data strongly suggest that AT1 receptors are involved in this interaction, since selective AT1 receptor blockade with losartan significantly reduced the angiotensin II induced norepinephrine concentration. Norepinephrine 180-194 angiotensin II receptor, type 1a Rattus norvegicus 95-98 11268389-6 2000 The HPA-activating activity of IL-1 is associated with increases in the apparent release of brain noradrenaline (NA) and serotonin (5-HT), but not dopamine, as well as with increased brain tryptophan. Norepinephrine 98-111 interleukin 1 complex Mus musculus 31-35 10890507-3 2000 The majority of cells were noradrenergic neurons in which dopamine-beta-hydroxylase, the enzyme that catalyzes norepinephrine synthesis, and neuropeptide Y coexisted. Norepinephrine 111-125 dopamine beta-hydroxylase Equus caballus 58-83 10601817-1 2000 Endotoxin (lipopolysaccharide, LPS) and interleukin-1 (IL-1) are known to activate the hypothalamo-pituitary- adrenocortical (HPA) axis, as well as brain norepinephrine (NE) and indoleamine metabolism. Norepinephrine 154-168 interleukin 1 complex Mus musculus 40-53 10601817-1 2000 Endotoxin (lipopolysaccharide, LPS) and interleukin-1 (IL-1) are known to activate the hypothalamo-pituitary- adrenocortical (HPA) axis, as well as brain norepinephrine (NE) and indoleamine metabolism. Norepinephrine 154-168 interleukin 1 complex Mus musculus 55-59 11113335-1 2000 Mice deficient in monoamine oxidase A have previously been shown to demonstrate a chronic elevation of serotonin and norepinephrine in the brain. Norepinephrine 117-131 monoamine oxidase A Mus musculus 18-37 10581494-4 1999 The Catechol-O-Methyltransferase (COMT) gene is an interesting candidate for ADHD as it is involved in the breakdown of dopamine and norepinephrine, neurotransmitters strongly implicated in the etiology of ADHD. Norepinephrine 133-147 catechol-O-methyltransferase Homo sapiens 4-32 10581494-4 1999 The Catechol-O-Methyltransferase (COMT) gene is an interesting candidate for ADHD as it is involved in the breakdown of dopamine and norepinephrine, neurotransmitters strongly implicated in the etiology of ADHD. Norepinephrine 133-147 catechol-O-methyltransferase Homo sapiens 34-38 10564704-0 1999 Salivary secretion of highly concentrated chromogranin a in response to noradrenaline and acetylcholine in isolated and perfused rat submandibular glands. Norepinephrine 72-85 chromogranin A Rattus norvegicus 42-56 10490706-7 1999 It should be noted that the association between the high-enzyme activity COMT val allele that increases CNS dopamine (and norepinephrine) clearance is consistent with the use of methylphenidate, an agent that increases dopamine (and norepinephrine) turnover, in the treatment of this disorder. Norepinephrine 122-136 catechol-O-methyltransferase Homo sapiens 73-77 10490706-7 1999 It should be noted that the association between the high-enzyme activity COMT val allele that increases CNS dopamine (and norepinephrine) clearance is consistent with the use of methylphenidate, an agent that increases dopamine (and norepinephrine) turnover, in the treatment of this disorder. Norepinephrine 233-247 catechol-O-methyltransferase Homo sapiens 73-77 10499537-11 1999 These studies establish that norepinephrine is required for leptin to regulate its own expression in WAT and UCP1 expression in BAT and indicate that these effects are likely mediated through the centrally expressed long form of the leptin receptor. Norepinephrine 29-43 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 109-113 10555559-5 1999 Treatment of mouse brown adipocytes in primary culture with noradrenaline also triggered a dose-dependent increase of the levels of UCP1 mRNA and UCP2 mRNA. Norepinephrine 60-73 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 132-136 10448071-3 1999 We have investigated the ability of norepinephrine (NE), which rises rapidly in plasma after liver resection, to trigger elevated production of HGF in MRC-5 human embryonic lung fibroblasts. Norepinephrine 36-50 hepatocyte growth factor Homo sapiens 144-147 10432475-4 1999 The selective 5-HT1A receptor antagonist, WAY100,635, slightly attenuated the (-)-pindolol-induced increase in DA and NAD levels, while the selective 5-HT1B antagonist, SB224,289, was ineffective. Norepinephrine 118-121 5-hydroxytryptamine receptor 1A Rattus norvegicus 14-20 10423683-10 1999 In the adult, AChE activity was weakly seen in the clusters of several chromaffin cells showing noradrenaline fluorescence in the adrenal medulla. Norepinephrine 96-109 acetylcholinesterase Mus musculus 14-18 10423684-5 1999 AChE activity was strong in a few large ganglion cells and weak in chromaffin cells showing noradrenaline fluorescence, and was found in numerous nerve bundles and fibers of the medulla. Norepinephrine 92-105 acetylcholinesterase Mus musculus 0-4 10212292-2 1999 We show with an in vivo approach that the norepinephrine cAMP-dependent rhythmic hormone production in rat pineal gland is accompanied by a temporally regulated switch in the ratio of a transcriptional activator, phosphorylated cAMP-responsive element-binding protein (pCREB), and a transcriptional inhibitor, inducible cAMP early repressor (ICER). Norepinephrine 42-56 cAMP responsive element modulator Rattus norvegicus 310-340 10212292-2 1999 We show with an in vivo approach that the norepinephrine cAMP-dependent rhythmic hormone production in rat pineal gland is accompanied by a temporally regulated switch in the ratio of a transcriptional activator, phosphorylated cAMP-responsive element-binding protein (pCREB), and a transcriptional inhibitor, inducible cAMP early repressor (ICER). Norepinephrine 42-56 cAMP responsive element modulator Rattus norvegicus 342-346 10344349-1 1999 BACKGROUND: Pregnant rats with adriamycin nephropathy (ADRP rats) develop hypertension and have an increased vascular reactivity to noradrenaline in the isolated mesenteric bed in vitro. Norepinephrine 132-145 perilipin 2 Rattus norvegicus 55-59 10435003-7 1999 Noradrenaline (NA, 1 microM) was used to stimulate beta 1-AR and isoprenaline (ISO, 1 microM) in the presence of the beta 1-AR antagonist CGP 20712A (0.1 microM) to stimulate beta 2-AR. Norepinephrine 0-13 adrenoceptor beta 1 Homo sapiens 51-60 10435003-7 1999 Noradrenaline (NA, 1 microM) was used to stimulate beta 1-AR and isoprenaline (ISO, 1 microM) in the presence of the beta 1-AR antagonist CGP 20712A (0.1 microM) to stimulate beta 2-AR. Norepinephrine 0-13 adrenoceptor beta 1 Homo sapiens 117-126 10192100-5 1999 The Mgi of the lymphocytes treated in vitro with noradrenaline (NA) significantly decreased in comparison with the control (M +/- SD, basal: 244 +/- 26 mumol/l; NA: 198 +/- 25 mumol/l; p = 0.0001), whereas it did not change after incubation with NA and propranolol (P) (M +/- SD, basal: 238 +/- 32 mumol/l; NA + P: 239 +/- 30 mumol/l; NS). Norepinephrine 49-62 MSD Homo sapiens 124-132 10192100-5 1999 The Mgi of the lymphocytes treated in vitro with noradrenaline (NA) significantly decreased in comparison with the control (M +/- SD, basal: 244 +/- 26 mumol/l; NA: 198 +/- 25 mumol/l; p = 0.0001), whereas it did not change after incubation with NA and propranolol (P) (M +/- SD, basal: 238 +/- 32 mumol/l; NA + P: 239 +/- 30 mumol/l; NS). Norepinephrine 49-62 MSD Homo sapiens 270-278 9920865-3 1999 Here we show that MIF is able to catalyze the conversion of 3,4-dihydroxyphenylaminechrome and norepinephrinechrome, toxic quinone products of the neurotransmitter catecholamines 3,4-dihydroxyphenylamine and norepinephrine, to indoledihydroxy derivatives that may serve as precursors to neuromelanin. Norepinephrine 95-109 macrophage migration inhibitory factor Homo sapiens 18-21 10218872-1 1999 Recent studies indicate that 5-HT1A receptor agonists stimulate noradrenaline release in the brain. Norepinephrine 64-77 5-hydroxytryptamine receptor 1A Rattus norvegicus 29-35 10218872-2 1999 Here we investigate the mechanism underlying the increase in extracellular noradrenaline induced by (+/-)-MDL 73005EF, a weak 5-HT1A receptor agonist. Norepinephrine 75-88 5-hydroxytryptamine receptor 1A Rattus norvegicus 126-132 10218872-12 1999 In conclusion, our data suggest that (+/-)-MDL 73005EF increases noradrenaline release in rat hippocampus through activation of 5HT1A receptors that appear to be located postsynaptically. Norepinephrine 65-78 5-hydroxytryptamine receptor 1A Rattus norvegicus 128-133 9884381-10 1999 CONCLUSIONS: Norepinephrine and epinephrine hasten human ventricular relaxation and promote phosphorylation of implicated proteins through both beta1- and beta2-adrenergic receptors, thereby potentially improving diastolic function. Norepinephrine 13-27 adrenoceptor beta 1 Homo sapiens 144-181 9831823-2 1999 Adrenergic agonists and antagonists showed activation and inhibition constants consistent with the presence of beta2-receptors: Ka of isoproterenol < epinephrine < norepinephrine < phenylephrine; Ki of timolol < betaxolol < celiprolol < atenolol. Norepinephrine 170-184 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 111-116 9928772-7 1999 In preparations from animals treated 14 days previously with intrathecal NGF, 69% of neurons responded with depolarizing responses whilst 18% of neurons responded to bath applied noradrenaline in tissue prepared from naive animals. Norepinephrine 179-192 nerve growth factor Rattus norvegicus 73-76 10573779-3 1999 There is an ongoing thoracolumbar sympathetic outflow to the lower urinary tract during filling, and noradrenaline, released from adrenergic nerves and acting through stimulation of beta-adrenoceptors (beta 2 and beta 3), may relax the bladder, due to a relative dominance of beta- over alpha-adrenoceptors in the detrusor. Norepinephrine 101-114 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 202-219 9832123-6 1998 It is interesting that norepinephrine, which exhibited no effect on galanin mRNA expression, induced a down-regulation in the level of galanin or galanin-like product accumulated in the medium of cultured ODM-2 cells to levels even lower than those induced by beta2-adrenergic agonists. Norepinephrine 23-37 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 260-265 9879729-0 1998 ORL1 receptor-mediated inhibition by nociceptin of noradrenaline release from perivascular sympathetic nerve endings of the rat tail artery. Norepinephrine 51-64 opioid related nociceptin receptor 1 Rattus norvegicus 0-4 9799438-3 1998 In a previous study in the pancreas of newborn guinea pig we reported the colocalization of nicotinamide adenine dinucleotide hydrogen phosphate-diaphorase (NADPH-d), a marker for nitric oxide synthase (NOS) with various neuropeptides as well as dopamine-beta-hydroxylase (DbetaH), the enzyme responsible for converting dopamine to noradrenaline. Norepinephrine 332-345 nitric oxide synthase, inducible Cavia porcellus 180-201 9722148-0 1998 The human immunodeficiency virus-1 envelope protein gp120 binds through its V3 sequence to the glycine site of N-methyl-D-aspartate receptors mediating noradrenaline release in the hippocampus. Norepinephrine 152-165 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 52-57 9722148-1 1998 Recent results show that the HIV-1 protein gp120 can enhance N-methyl-D-aspartate receptor-mediated release of noradrenaline from CNS nerve endings. Norepinephrine 111-124 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 43-48 9712661-0 1998 Plasma membrane transporters of serotonin, dopamine, and norepinephrine mediate serotonin accumulation in atypical locations in the developing brain of monoamine oxidase A knock-outs. Norepinephrine 57-71 monoamine oxidase A Mus musculus 152-171 9712709-1 1998 Phenylethanolamine N-methyltransferase (PNMT) catalyzes the production of epinephrine from norepinephrine using S-adenosyl-L-methionine as a methyl donor. Norepinephrine 91-105 phenylethanolamine N-methyltransferase Homo sapiens 0-38 9712709-1 1998 Phenylethanolamine N-methyltransferase (PNMT) catalyzes the production of epinephrine from norepinephrine using S-adenosyl-L-methionine as a methyl donor. Norepinephrine 91-105 phenylethanolamine N-methyltransferase Homo sapiens 40-44 9702745-10 1998 Individuals with COMT LL would be expected to have higher levels of transynaptic catecholamines due to a reduced COMT degradation of norepinephrine and dopamine. Norepinephrine 133-147 catechol-O-methyltransferase Homo sapiens 17-21 9702745-10 1998 Individuals with COMT LL would be expected to have higher levels of transynaptic catecholamines due to a reduced COMT degradation of norepinephrine and dopamine. Norepinephrine 133-147 catechol-O-methyltransferase Homo sapiens 113-117 9754635-5 1998 Intraperitoneal injections of various doses (0.2-2 mg kg(-1)) of noradrenaline and adrenaline dose-dependently induced hepatic c-fos and c-jun mRNA levels. Norepinephrine 65-78 jun proto-oncogene Mus musculus 137-142 9754635-6 1998 The time-course study showed that there was an increase in c-fos and c-jun mRNA levels within 15 min, which reached a peak at 30 min, and returned to the basal levels 1-2 h after noradrenaline or adrenaline injection (2 mg kg(-1), i.p.). Norepinephrine 179-192 jun proto-oncogene Mus musculus 69-74 9754635-7 1998 A Western blot assay revealed that c-Jun protein levels were maximally increased at 30 min and 1-2 h in noradrenaline- and adrenaline-treated mice, respectively. Norepinephrine 104-117 jun proto-oncogene Mus musculus 35-40 9754635-23 1998 The results suggest that noradrenaline elicits the hepatic c-fos and c-jun mRNA responses by stimulating alpha1-adrenergic receptors, whereas in the case of adrenaline, this is elicited by stimulating both alpha1- and beta2-adrenergic receptors in mice. Norepinephrine 25-38 jun proto-oncogene Mus musculus 69-74 9573502-10 1998 Compared to placebo, hBNP decreased plasma norepinephrine and aldosterone. Norepinephrine 43-57 natriuretic peptide B Homo sapiens 21-25 9573502-14 1998 3) Plasma norepinephrine and aldosterone levels decreased during hBNP infusion. Norepinephrine 10-24 natriuretic peptide B Homo sapiens 65-69 9556076-4 1998 Neuronal AT1 receptors are involved in norepinephrine (NE) neuromodulation. Norepinephrine 39-53 angiotensin II receptor type 1 Homo sapiens 9-12 9461536-0 1998 Effects of noradrenaline on the cell-surface glucose transporters in cultured brown adipocytes: novel mechanism for selective activation of GLUT1 glucose transporters. Norepinephrine 11-24 solute carrier family 2 member 1 Rattus norvegicus 140-145 9461536-7 1998 However, noradrenaline induced an increase in photoaffinity labelling of cell-surface GLUT1 without an apparent increase in the immunoreactive GLUT1 protein in the plasma membrane. Norepinephrine 9-22 solute carrier family 2 member 1 Rattus norvegicus 86-91 9461536-10 1998 The increased photoaffinity labelling of GLUT1 and increased glucose transport caused by noradrenaline were inhibited by a cAMP antagonist, cAMP-S Rp-isomer. Norepinephrine 89-102 solute carrier family 2 member 1 Rattus norvegicus 41-46 9461536-11 1998 These results demonstrate that noradrenaline stimulates glucose transport in brown adipocytes by enhancing the functional activity of GLUT1 through a cAMP-dependent mechanism. Norepinephrine 31-44 solute carrier family 2 member 1 Rattus norvegicus 134-139 9833158-2 1998 Consequently, the inhibition of the converting enzyme by ACE inhibitors resulting in a lower concentration of angiotensin II or blockade of the specific AT1 receptors by AT1 receptor blocking agents should lead to a decrease in both noradrenaline and adrenaline release. Norepinephrine 233-246 angiotensin II receptor, type 1a Rattus norvegicus 153-156 9833158-2 1998 Consequently, the inhibition of the converting enzyme by ACE inhibitors resulting in a lower concentration of angiotensin II or blockade of the specific AT1 receptors by AT1 receptor blocking agents should lead to a decrease in both noradrenaline and adrenaline release. Norepinephrine 233-246 angiotensin II receptor, type 1a Rattus norvegicus 170-173 9833158-3 1998 It has been demonstrated that ACE inhibition did not influence the net catecholamine overflow during stimulation of the sympathetic nerves in contrast to AT1 antagonists which can specifically and dose dependently diminish noradrenaline and adrenaline release, an effect that could be explained by a compensating mechanism of bradykinin. Norepinephrine 223-236 angiotensin II receptor, type 1a Rattus norvegicus 154-157 9833158-6 1998 As could be demonstrated with losartan and HR 720, candesartan lowered AT1 receptor mediated angiotensin II-induced noradrenaline release in a dose-dependent manner. Norepinephrine 116-129 angiotensin II receptor, type 1a Rattus norvegicus 71-74 9661134-2 1998 In the present study, the relevance of AT1-mediated noradrenaline and adrenaline release in a whole-animal model, which reflects the peripherally sympathetic system (pithed rat), was investigated. Norepinephrine 52-65 angiotensin II receptor, type 1a Rattus norvegicus 39-42 9585117-4 1998 The alpha1B-adrenoceptor subtype may be located on a space more proximal to the sympathetic nerve endings than the alpha1A-adrenoceptor subtype, because the positive inotropic effect of endogenous norepinephrine was mediated entirely by the alpha1B-adrenoceptor subtype. Norepinephrine 197-211 adrenoceptor alpha 1A Homo sapiens 115-135 9389511-0 1997 Norepinephrine stimulates mitogen-activated protein kinase activity in GT1-1 gonadotropin-releasing hormone neuronal cell lines. Norepinephrine 0-14 retinoic acid induced 1 Mus musculus 71-76 9388051-11 1997 We conclude that angiotensin-(1-7) is a component of the renin-angiotensin system that acts to modulate the pressor effects of angiotensin II and noradrenaline. Norepinephrine 146-159 renin Rattus norvegicus 57-62 9652973-4 1997 Neuronal AT1 receptors are involved in norepinephrine (NE) neuromodulation. Norepinephrine 39-53 angiotensin II receptor type 1 Homo sapiens 9-12 9337215-8 1997 Plasma norepinephrine and endothelin increased by more than fivefold with chronic pacing and remained elevated with AT1 Ang II blockade. Norepinephrine 7-21 angiotensin II receptor type 1 Sus scrofa 116-119 9403317-4 1997 Norepinephrine and epinephrine operate through differential recruitment of alpha 2- and beta-AR subtypes on the basis of their relative affinity for the different subtypes (the relative order of affinity is alpha 2 > beta 1 > or = beta 2 > beta 3 for norepinephrine). Norepinephrine 0-14 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 237-243 9352569-1 1997 Catechol-O-methyltransferase catalyses the O-methylation of biologically active or toxic catechols and is a major component of the metabolism of drugs and neurotransmitters such as L-dopa, noradrenaline, adrenaline, and dopamine. Norepinephrine 189-202 catechol-O-methyltransferase Homo sapiens 0-28 9322222-4 1997 The hypothesized pathway is via norepinephrine-induced release of NO from NOergic neurons which activates LHRH release. Norepinephrine 32-46 gonadotropin releasing hormone 1 Homo sapiens 106-110 9159177-1 1997 Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex, hippocampus, and cerebellum, compared with normal wild-type mice. Norepinephrine 92-106 monoamine oxidase A Mus musculus 18-37 9159177-1 1997 Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex, hippocampus, and cerebellum, compared with normal wild-type mice. Norepinephrine 92-106 monoamine oxidase A Mus musculus 39-43 9159177-1 1997 Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex, hippocampus, and cerebellum, compared with normal wild-type mice. Norepinephrine 136-150 monoamine oxidase A Mus musculus 18-37 9159177-1 1997 Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex, hippocampus, and cerebellum, compared with normal wild-type mice. Norepinephrine 136-150 monoamine oxidase A Mus musculus 39-43 9054858-0 1997 Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both alpha 1- and beta-adrenoceptors. Norepinephrine 0-14 Raf-1 proto-oncogene, serine/threonine kinase Rattus norvegicus 27-32 9054858-2 1997 METHODS AND RESULTS: To elucidate the molecular mechanism of norepinephrine-induced hypertrophic responses, we examined the effects of protein kinase A and protein kinase C on the activities of raf-1 kinase and mitogen-activated protein (MAP) kinases and on protein synthesis rates using cultured cardiomyocytes of neonatal rats. Norepinephrine 61-75 Raf-1 proto-oncogene, serine/threonine kinase Rattus norvegicus 194-199 9054858-8 1997 CONCLUSIONS: Norepinephrine activates the raf-1 kinase/MAP kinase cascade through both alpha 1- and beta-adrenergic stimulation, and signaling pathways from the two receptors synergistically induce cardiomyocyte hypertrophy. Norepinephrine 13-27 Raf-1 proto-oncogene, serine/threonine kinase Rattus norvegicus 42-47 24394658-9 1997 Although the development of thromboxane-like constrictor response, after the inhibition of nitric oxide in hypertensive vessels, was unaffected by test diets, both TRF and GPO feeding prevented the amplification of this unwanted constriction by a threshold dose (7.2x10-10 M) of noradrenaline. Norepinephrine 279-292 interleukin 5 Rattus norvegicus 164-167 9138687-0 1997 Pharmacological characterization of an alpha 1A-adrenoceptor mediating contractile responses to noradrenaline in isolated caudal artery of rat. Norepinephrine 96-109 adrenoceptor alpha 1A Rattus norvegicus 39-60 9048762-7 1997 The present data demonstrate that combined blockade of 5-HT1A and 5-HT1B autoreceptors markedly and selectively potentiates the fluoxetine-induced increase in dialysate levels of 5-HT versus DA and NAD in the FCx of freely moving rats. Norepinephrine 198-201 5-hydroxytryptamine receptor 1A Rattus norvegicus 55-72 9121699-1 1997 Catechol-O-methyltransferase (COMT) is an enzyme that inactivates catecholamines such as adrenaline, noradrenaline, dopamine, and levodopa. Norepinephrine 101-114 catechol-O-methyltransferase Homo sapiens 0-28 9121699-1 1997 Catechol-O-methyltransferase (COMT) is an enzyme that inactivates catecholamines such as adrenaline, noradrenaline, dopamine, and levodopa. Norepinephrine 101-114 catechol-O-methyltransferase Homo sapiens 30-34 9393937-0 1997 Antagonism to noradrenaline-induced lethality in rats is related to affinity for the alpha1A-adrenoceptor subtype. Norepinephrine 14-27 adrenoceptor alpha 1A Rattus norvegicus 85-105 9393937-2 1997 The potency of the tested compounds as antagonists of noradrenaline-induced lethality was correlated with the affinity for the alpha1A- (and alpha1a-) adrenoceptor subtype, but not with the affinity for the other subtypes. Norepinephrine 54-67 adrenoceptor alpha 1A Rattus norvegicus 141-163 9414459-3 1997 This review documents recent progress in understanding the role of noradrenaline within the GnRH network and highlights and explains its "enabling" or permissive characteristics. Norepinephrine 67-80 gonadotropin releasing hormone 1 Homo sapiens 92-96 9414459-4 1997 Network behaviour analysis suggests that noradrenaline should be considered as a permissive agent promoting high output states of the GnRH network. Norepinephrine 41-54 gonadotropin releasing hormone 1 Homo sapiens 134-138 9414459-6 1997 In this manner, noradrenaline is likely to play a role in bringing about the increased GnRH messenger RNA expression and secretion necessary for ovulation. Norepinephrine 16-29 gonadotropin releasing hormone 1 Homo sapiens 87-91 8971795-4 1996 These results indicate that the effects of serotonergic antidepressant drugs (but not those of desipramine, which mainly blocks noradrenaline reuptake) can be potentiated by 5-HT1A autoreceptor blockade. Norepinephrine 128-141 5-hydroxytryptamine receptor 1A Rattus norvegicus 174-180 8900127-5 1996 Norepinephrine triggered GLUT4 translocation in cells expressing the Gq-coupled alpha1-adrenergic receptor, but prostaglandin E2 did not cause GLUT4 translocation in cells expressing the Gs-coupled EP4 receptor or the Gi-coupled EP3alpha receptor. Norepinephrine 0-14 solute carrier family 2 member 4 Homo sapiens 25-30 8853428-5 1996 Angiotensin II and norepinephrine reduced predominantly only CBF (-24 and -19%, respectively). Norepinephrine 19-33 CCAAT/enhancer binding protein zeta Rattus norvegicus 61-64 8710943-3 1996 During neonatal cardiomyocyte hypertrophy induced by norepinephrine or spontaneous contraction, changes in the expression of a ribosomal DNA transcription factor, UBF, correlated with increased rates of ribosome biogenesis. Norepinephrine 53-67 upstream binding transcription factor Homo sapiens 163-166 8796125-0 1996 Norepinephrine induces cardiac heat shock protein 70 and delayed cardioprotection in the rat through alpha 1 adrenoceptors. Norepinephrine 0-14 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 31-52 8817112-5 1996 Beta 3-adrenergic receptor function was investigated by measuring lipolysis in isolated visceral white fat cells incubated with noradrenaline (natural ligand) or (CGP) 12,177 (selective beta 3-agonist). Norepinephrine 128-141 adrenoceptor beta 3 Homo sapiens 0-26 8724036-10 1996 Finally, gp120 reversed (1 nM) and surmounted (10nM) the antagonism by 10 microM 7-chlorokynurenate of the NMDA-evoked [3H]-noradrenaline release. Norepinephrine 124-137 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 9-14 8911654-7 1996 For example, plasma NPY, a peptide co-localized with norepinephrine in the sympathetic nervous system, is low in patients with FM. Norepinephrine 53-67 neuropeptide Y Homo sapiens 20-23 9053060-1 1996 Corticotropin-releasing hormone administration into the neostriatum was shown to increase the level of corticosterone in the blood, as well as adrenaline and noradrenaline contents in the adrenal glands. Norepinephrine 158-171 corticotropin releasing hormone Homo sapiens 0-31 8755013-2 1996 The selective alpha-1 blockers reduce peripheral vascular resistance by blocking the alpha-1 receptors and preventing norepinephrine from reaching them. Norepinephrine 118-132 adrenoceptor alpha 1D Homo sapiens 14-21 8780011-0 1996 Noradrenaline increases the expression of the proenkephalin gene in cultured astroglial cells by acting on beta 1- and alpha 1-adrenoceptors. Norepinephrine 0-13 proenkephalin Rattus norvegicus 46-59 8780011-4 1996 In the present study, how noradrenaline affected the expression of the proenkephalin gene in both cell types was investigated. Norepinephrine 26-39 proenkephalin Rattus norvegicus 71-84 8848409-1 1996 Neuropeptide Y (NPY) has been recently characterized as a circulating vasoconstrictor peptide which is co-stored with noradrenaline in sympathetic neurons. Norepinephrine 118-131 neuropeptide Y Homo sapiens 0-20 8740147-8 1996 In lungs perfused with 1 nmol/l 3H-noradrenaline (COMT inhibited), 10, 30 and 300 nmol/l amezinium caused 58%, 76% and 74% inhibition of noradrenaline deamination, respectively, and 30, 300 and 3000 nmol/l debrisoquine caused 56%, 89% and 96% inhibition of noradrenaline deamination, respectively. Norepinephrine 35-48 catechol-O-methyltransferase Rattus norvegicus 50-54 8935709-3 1996 Monoamine oxidase was inhibited and, in experiments with noradrenaline, catechol-O-methyltransferase was also inhibited. Norepinephrine 57-70 catechol-O-methyltransferase Rattus norvegicus 72-100 9053798-1 1996 Norepinephrine-containing fibres in the medial prefrontal cortex derive from the locus coeruleus, a brainstem nucleus which also receives a dense innervation of enkephalin-immunoreactive axon terminals. Norepinephrine 0-14 proenkephalin Rattus norvegicus 161-171 8591854-0 1996 Norepinephrine reverses the effects of activin A on DNA synthesis and apoptosis in cultured rat hepatocytes. Norepinephrine 0-14 inhibin subunit beta A Rattus norvegicus 39-48 8917909-2 1996 Generally, in anestrous ewes beta-endorphin and/or corticoliberin significantly change extracellular concentrations of monoamine metabolites in the MBH-ME, but in estrous ewes both beta-endorphin and CRF alters also dopamine, noradrenaline and serotonin levels. Norepinephrine 226-239 corticotropin releasing hormone Homo sapiens 51-65 8722501-1 1996 Neuropeptide Y is a sympathetic co-neurotransmitter released with noradrenaline upon sympathetic nerve stimulation. Norepinephrine 66-79 neuropeptide Y Homo sapiens 0-14 8746761-2 1996 Sympathetic nerve fibres, with their origin in the superior cervical ganglia, contain neuropeptide Y colocalized with norepinephrine. Norepinephrine 118-132 neuropeptide Y Homo sapiens 86-100 8787934-3 1996 Clear inter-individual variations in the adipocyte lipolytic adrenoceptor sensitivity (pD2) for noradrenaline were observed in dose-response experiments (i.e., about 4 log units). Norepinephrine 96-109 PAF1 homolog, Paf1/RNA polymerase II complex component Homo sapiens 87-90 8787934-4 1996 An inverse and independent correlation was found between the 24-hour systolic blood pressure and pD2 for noradrenaline (r = -0.67, p < 0.01). Norepinephrine 105-118 PAF1 homolog, Paf1/RNA polymerase II complex component Homo sapiens 97-100 8821761-5 1995 All these results suggest that norepinephrine, through stimulation of both alpha 1- and alpha 2- (alpha 2A- and alpha 2B/2C-) adrenoceptor subtypes, is involved in producing fever in response to bacterial LPS. Norepinephrine 31-45 alpha-2A adrenergic receptor Oryctolagus cuniculus 98-138 9019375-7 1995 Noradrenaline and histamine evoked concentration dependent constrictions which were potentiated by neuropeptide Y (3 x 10(-7) M). Norepinephrine 0-13 neuropeptide Y Oryctolagus cuniculus 99-113 8529333-2 1995 Human neuropeptide Y is an endogenous vasoconstrictor peptide that is costored with norepinephrine in sympathetic nerve endings and coreleased with the catecholamine under various physiologic and pathologic conditions. Norepinephrine 84-98 neuropeptide Y Homo sapiens 6-20 9053735-5 1995 In the presence of indometacin and yohimbine, sulprostone (an agonist at EP1/EP3 receptors) and misoprostol (an agonist at EP2/EP3 receptors) reduced the noradrenaline overflow evoked by stimulation at 3 Hz maximally by about 80% (EC50: 6 nmol/l and 11 nmol/l, respectively). Norepinephrine 154-167 prostaglandin E receptor 2 Rattus norvegicus 123-140 7486151-11 1995 In contrast, affected limbs of NP2 rats had a reduced arteriovenous increment in norepinephrine concentrations, compared to that in the control side (P < 0.05). Norepinephrine 81-95 neuronal pentraxin 2 Rattus norvegicus 31-34 8697051-7 1995 The relative order of affinity of the various fat cell ARs for the physiological amines defined in binding studies and in vitro assays is alpha 2 > beta 1 > or = beta 2 > beta 3 for norepinephrine and alpha 2 > beta 2 > beta 1 > beta 3 for epinephrine. Norepinephrine 191-205 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 180-186 8748207-5 1995 Neuropeptide Y potentiated the mitogenic effect of noradrenaline, and together with adenosine 5"-triphosphate, the sympathetic cotransmitters reached a mitogenic effect of approximately 20% of fetal calf serum. Norepinephrine 51-64 neuropeptide Y Homo sapiens 0-14 7498294-3 1995 The alpha 1-adrenoceptor antagonist prazosin antagonized the contraction elicited by noradrenaline and phenylephrine. Norepinephrine 85-98 adrenoceptor alpha 1D Homo sapiens 4-11 7616202-2 1995 We previously generated transgenic mice expressing phenylethanolamine N-methyltransferase (PNMT) under the control of a human dopamine beta-hydroxylase gene promoter to switch catecholamine specificity from the norepinephrine phenotype to the epinephrine phenotype. Norepinephrine 211-225 dopamine beta-hydroxylase Homo sapiens 126-151 7616203-3 1995 In situ, the cDNA hybridizes specifically within norepinephrine-secreting cells, but in neither dopamine nor serotonin neurons, suggesting strongly it is a partial rat norepinephrine transporter cDNA. Norepinephrine 49-63 solute carrier family 6 member 2 Rattus norvegicus 168-194 7580872-3 1995 S-antigen immunoreactive pinealocytes were shown to respond to norepinephrine stimulation with an elevation of the intracellular free calcium concentration ([Ca2+]i). Norepinephrine 63-77 S-antigen visual arrestin Rattus norvegicus 0-9 7543257-4 1995 With norepinephrine, serotonin, prostaglandin F2 alpha, and K+, Cao from 0.025 to 0.8 mM induced a graded increase in Cai and active stress. Norepinephrine 5-19 carbonic anhydrase 1 Rattus norvegicus 118-121 7631894-4 1995 A net uptake of norepinephrine was found in resting legs at sea level (0.28 +/- 0.05 nmol/min) and with acute exposure (0.07 +/- 0.06 nmol/min); however, a significant switch to net leg norepinephrine release was observed with chronic altitude exposure (0.51 +/- 0.11 nmol/min). Norepinephrine 16-30 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 60-63 7631894-5 1995 With exercise, a net release of norepinephrine by the leg occurred across all conditions with chronic exposure, again eliciting the greatest values (5.3 +/- 0.6, 8.0 +/- 1.7, and 14.4 +/- 3.1 nmol/min for sea level, acute, and chronic exposure, respectively). Norepinephrine 32-46 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 205-208 7792602-1 1995 Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family. Norepinephrine 80-94 monoamine oxidase A Homo sapiens 14-33 7792602-1 1995 Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family. Norepinephrine 80-94 monoamine oxidase A Homo sapiens 35-39 7635178-5 1995 The delta-opioid receptor agonist, [D-Pen2,D-Pen5]enkephalin, had no effect on resting tension but potentiated the contractions induced by noradrenaline; these effects were abolished by naltrindol. Norepinephrine 139-152 proenkephalin Rattus norvegicus 50-60 7630431-0 1995 Evidence for saturation of catechol-O-methyltransferase by low concentrations of noradrenaline in perfused lungs of rats. Norepinephrine 81-94 catechol-O-methyltransferase Rattus norvegicus 27-55 7630431-1 1995 Previous studies on the pulmonary removal and metabolism of catecholamines in rat lungs have shown that, when the lungs are perfused with a low concentration (1 nmol/l) of noradrenaline, the amine is metabolized by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO), but is predominantly O-methylated, and the activities of COMT and MAO are 0.357 min-1 and 0.186 min-1, respectively. Norepinephrine 172-185 catechol-O-methyltransferase Rattus norvegicus 215-243 7630431-1 1995 Previous studies on the pulmonary removal and metabolism of catecholamines in rat lungs have shown that, when the lungs are perfused with a low concentration (1 nmol/l) of noradrenaline, the amine is metabolized by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO), but is predominantly O-methylated, and the activities of COMT and MAO are 0.357 min-1 and 0.186 min-1, respectively. Norepinephrine 172-185 catechol-O-methyltransferase Rattus norvegicus 245-249 7630431-1 1995 Previous studies on the pulmonary removal and metabolism of catecholamines in rat lungs have shown that, when the lungs are perfused with a low concentration (1 nmol/l) of noradrenaline, the amine is metabolized by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO), but is predominantly O-methylated, and the activities of COMT and MAO are 0.357 min-1 and 0.186 min-1, respectively. Norepinephrine 172-185 catechol-O-methyltransferase Rattus norvegicus 337-341 7648607-8 1995 There is a concomitant increase in excitatory inputs, mainly noradrenaline, excitatory amino acids, and NPY, which increase the synthesis and release of GnRH at the beginning of the juvenile period and participate in the coupling of GnRH neural activity to the ongoing rhythmic activity of a hypothalamic circadian oscillator. Norepinephrine 61-74 gonadotropin releasing hormone 1 Rattus norvegicus 153-157 7648607-8 1995 There is a concomitant increase in excitatory inputs, mainly noradrenaline, excitatory amino acids, and NPY, which increase the synthesis and release of GnRH at the beginning of the juvenile period and participate in the coupling of GnRH neural activity to the ongoing rhythmic activity of a hypothalamic circadian oscillator. Norepinephrine 61-74 gonadotropin releasing hormone 1 Rattus norvegicus 233-237 7542993-1 1995 Glutamic acid (GA) and norepinephrine (NE) stimulate luteinizing hormone-releasing hormone (LHRH) release via release of nitric oxide (NO) from NOergic neurons in the arcuate-median eminence region. Norepinephrine 23-37 gonadotropin releasing hormone 1 Rattus norvegicus 53-90 7542993-1 1995 Glutamic acid (GA) and norepinephrine (NE) stimulate luteinizing hormone-releasing hormone (LHRH) release via release of nitric oxide (NO) from NOergic neurons in the arcuate-median eminence region. Norepinephrine 23-37 gonadotropin releasing hormone 1 Rattus norvegicus 92-96 7775405-3 1995 Continuous administration of noradrenaline or isoproterenol (beta-agonist) for 10 days resulted in increased synthesis of the mitochondrial uncoupling protein and an isoform of glucose transporter (GLUT4), and tissue hyperplasia, in the same way as after cold exposure of the same duration. Norepinephrine 29-42 solute carrier family 2 member 4 Rattus norvegicus 198-203 8584674-1 1995 Monoamine oxidase (MAO) A (EC 1.4.3.4) oxidizes norepinephrine and serotonin and is expressed in a cell type-specific manner. Norepinephrine 48-62 monoamine oxidase A Homo sapiens 0-25 7695023-4 1994 In early withdrawal, there was a significant positive correlation between CSF norepinephrine (NE) and corticotropin releasing hormone (CRH) concentrations (r = 0.95, p < 0.001). Norepinephrine 78-92 corticotropin releasing hormone Homo sapiens 135-138 7844319-1 1994 3-Methoxy-4-hydroxyphenylglycol (MHPG) is formed by the sequential actions of monoamine oxidase (MAO) and catechol-O-methyltransferase on norepinephrine within extraneuronal tissues or by extraneuronal O-methylation of 3,4-dihydroxyphenylglycol (DHPG) produced intraneuronally from norepinephrine. Norepinephrine 138-152 catechol-O-methyltransferase Rattus norvegicus 106-134 7833428-4 1994 However, when the effects of CRH were followed over a longer period in a small subgroup, we found that CRH administration produced a two-fold rise in plasma HVA levels 20 hours later, without affecting plasma levels of 3-methoxy-4-hydroxyphenylglycol (MHPG), a major metabolite of norepinephrine. Norepinephrine 281-295 corticotropin releasing hormone Homo sapiens 103-106 7525897-1 1994 Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine, and is expressed specifically in neurons and neuroendocrine cells that release norepinephrine and epinephrine. Norepinephrine 72-86 dopamine beta-hydroxylase Rattus norvegicus 0-25 7800657-3 1994 Moreover, the inhibitor of dopamine-beta-hydroxylase, disulfiram, caused significant decrease in brain noradrenaline (NA) and significant increase in brain dopamine (DA) contents. Norepinephrine 103-116 dopamine beta-hydroxylase Homo sapiens 27-52 8076685-1 1994 The addition of corticotropin-releasing factor (CRF) to molluscan hemocytes induces the release of biogenic amines (norepinephrine, epinephrine, dopamine), a phenomenon we have considered as an ancestral type of stress response [(1992) Gen. Comp. Norepinephrine 116-130 corticotropin releasing hormone Homo sapiens 16-46 7915614-10 1994 beta 2-Adrenoceptor-mediated relaxation responses to isoprenaline of the pulmonary artery, constricted with noradrenaline (6 x 10(-8) M), showed no significant difference in maximum response or EC50 in tissue from isoprenaline- or dopexamine-infused rats compared with vehicle-infused controls. Norepinephrine 108-121 adrenoceptor beta 2 Rattus norvegicus 0-19 7969507-0 1994 Pre- and postganglionic stimulation-induced noradrenaline overflow is markedly facilitated by a prejunctional beta 2-adrenoceptor-mediated control mechanism in the pithed rat. Norepinephrine 44-57 adrenoceptor beta 2 Rattus norvegicus 110-129 8032617-17 1994 However, surgical denervation of the rat kidney, resulting in more than 90% reduction in renal noradrenaline content, selectively reduced the beta 2-adrenoceptor population by 80%, implying the presence of beta 2-adrenoceptors on renal sympathetic nerve terminals. Norepinephrine 95-108 adrenoceptor beta 2 Rattus norvegicus 142-161 7509126-4 1994 By including the interactions of paranoia subscale by CSF norepinephrine and anxiety by CSF norepinephrine, the model correctly identified 20 relapsers and 23 nonrelapsers with a sensitivity and specificity of 83% and 88%, respectively. Norepinephrine 92-106 colony stimulating factor 2 Homo sapiens 88-91 7509734-10 1994 Norepinephrine and epinephrine infusions increased IGFBP-1 levels significantly (2- to 5-fold) in fetal plasma within 8-12 h, and the time course pattern of elevation of plasma IGFBP-1 levels was similar to that observed in prolonged hypoxia. Norepinephrine 0-14 insulin-like growth factor-binding protein 1 Ovis aries 51-58 7509734-10 1994 Norepinephrine and epinephrine infusions increased IGFBP-1 levels significantly (2- to 5-fold) in fetal plasma within 8-12 h, and the time course pattern of elevation of plasma IGFBP-1 levels was similar to that observed in prolonged hypoxia. Norepinephrine 0-14 insulin-like growth factor-binding protein 1 Ovis aries 177-184 7509734-11 1994 After 24 h of either norepinephrine or epinephrine infusion, IGFBP-1 mRNA levels in the liver of fetuses were increased significantly (5- to 7-fold) compared to those of vehicle infused fetuses. Norepinephrine 21-35 insulin-like growth factor-binding protein 1 Ovis aries 61-68 8046992-0 1994 Lead (Pb) alters the norepinephrine-induced secretion of luteinizing hormone releasing hormone from the median eminence of adult male rats in vitro. Norepinephrine 21-35 gonadotropin releasing hormone 1 Rattus norvegicus 57-94 8245983-5 1993 The rank order for substrate inhibition of [3H]5-HT uptake for both the previously reported rat vMAT1 and the human transporter clone followed the order 5-HT > dopamine > epinephrine > norepinephrine > 1-methyl-4-phenylpyridinium > 2-phenylethylamine > histamine. Norepinephrine 194-208 solute carrier family 18 member A1 Rattus norvegicus 96-101 7902747-4 1993 Analysis of the individual metabolites of inositol phospholipid metabolism formed in response to noradrenaline in PKC-depleted astrocytes revealed potentiated accumulations of radiolabelled glycerophosphoinositol (GPI), inositol monophosphate (IP1) and inositol bisphosphate (IP2) but not inositol trisphosphate (IP3) when compared to controls. Norepinephrine 97-110 inhibitor of nuclear factor kappa B kinase regulatory subunit gamma Homo sapiens 244-247 8372797-8 1993 The increase in the ejection fraction by these drugs and the decrease of plasma norepinephrine levels by ACE inhibitors may contribute to improved long-term survival. Norepinephrine 80-94 angiotensin I converting enzyme Canis lupus familiaris 105-108 7688735-1 1993 Dopamine beta-hydroxylase (DBH), the enzyme catalyzing the conversion of dopamine to norepinephrine, is specifically expressed in adrenergic and noradrenergic neurons in the central nervous system. Norepinephrine 85-99 dopamine beta-hydroxylase Homo sapiens 0-25 7688735-1 1993 Dopamine beta-hydroxylase (DBH), the enzyme catalyzing the conversion of dopamine to norepinephrine, is specifically expressed in adrenergic and noradrenergic neurons in the central nervous system. Norepinephrine 85-99 dopamine beta-hydroxylase Homo sapiens 27-30 8513972-5 1993 In all three groups, subcutaneous insulin activated the sympathetic nervous system (approximately 30% increase in norepinephrine concentration). Norepinephrine 114-128 insulin Bos taurus 34-41 8224732-4 1993 In the periphery, NPY coexists with noradrenaline (NA) in perivascular sympathetic fibers. Norepinephrine 36-49 neuropeptide Y Homo sapiens 18-21 7687716-1 1993 Neuropeptide Y (NPY), a potent vasoconstrictor agent reported to be released, in addition to norepinephrine (NE), by sympathetic nerve endings during stress, may contribute to the pressor response to various stimuli. Norepinephrine 93-107 neuropeptide Y Homo sapiens 0-14 7687716-1 1993 Neuropeptide Y (NPY), a potent vasoconstrictor agent reported to be released, in addition to norepinephrine (NE), by sympathetic nerve endings during stress, may contribute to the pressor response to various stimuli. Norepinephrine 93-107 neuropeptide Y Homo sapiens 16-19 8382264-1 1993 Administration of carbachol, noradrenaline, and bradykinin induced Egr-1 mRNA expression within 1 h in mouse neuroblastoma x rat glioma hybrid NG108-15 cells. Norepinephrine 29-42 early growth response 1 Mus musculus 67-72 8382264-2 1993 With specific receptor antagonists, the Egr-1 inductions by carbachol and noradrenaline were shown to be mediated via cholinergic muscarinic and alpha 2-adrenergic receptors, respectively. Norepinephrine 74-87 early growth response 1 Mus musculus 40-45 8382264-5 1993 On the other hand, bradykinin consistently had an additive effect on Egr-1 induction, irrespective of the time of its addition, suggesting that the signal pathways for Egr-1 induction by carbachol or noradrenaline and by bradykinin are different. Norepinephrine 200-213 early growth response 1 Mus musculus 168-173 8382264-6 1993 Treatment of cells with pertussis toxin or cholera toxin strongly inhibited Egr-1 induction by carbachol or noradrenaline but only partially inhibited the induction by bradykinin. Norepinephrine 108-121 early growth response 1 Mus musculus 76-81 8464343-4 1993 Furthermore, only in SHR, 10 U/ml erythropoietin enhanced contraction induced by 10(-7) M norepinephrine (+145% vs +121%, p < 0.04) and reduced relaxation by 10(-7) M acetylcholine (-69% vs -96%, p < 0.05). Norepinephrine 90-104 erythropoietin Rattus norvegicus 34-48 1363791-5 1992 One possible explanation for this muscarinically mediated stimulation of GnRH release is that it results from cross-talk between the muscarinic and the alpha 1-adrenergic receptors, i.e., muscarinic agonists might inhibit the release induced by alpha 1-agonists, and muscarinic antagonists, by cancelling this inhibitory effect, might thus allow the endogenous alpha 1-agent, norepinephrine, to induce the release of GnRH. Norepinephrine 376-390 gonadotropin releasing hormone 1 Rattus norvegicus 73-77 1475406-3 1992 Neuropeptide Y (NPY) induces direct vasoconstriction and potentiates the action of noradrenaline. Norepinephrine 83-96 neuropeptide Y Homo sapiens 0-14 1475406-3 1992 Neuropeptide Y (NPY) induces direct vasoconstriction and potentiates the action of noradrenaline. Norepinephrine 83-96 neuropeptide Y Homo sapiens 16-19 1475406-5 1992 In order to determine if NPY could be involved in the enhanced vascular sensitivity to noradrenaline associated with adrenocortical hyperactivity, we measured plasma NPY in patients with Cushing"s syndrome (n = 26) and primary hyperaldosteronism (n = 15) and compared it with that of hypertensive patients with pheochromocytomas (n = 13) or essential hypertension (n = 51) and with normotensive controls (n = 47). Norepinephrine 87-100 neuropeptide Y Homo sapiens 25-28 1280593-0 1992 Atrial natriuretic peptide suppresses renal vasoconstriction induced by angiotensin II and norepinephrine in dogs. Norepinephrine 91-105 natriuretic peptide A Canis lupus familiaris 0-26 1280593-1 1992 Atrial natriuretic peptide (ANP, 10 and 50 ng/kg per min), infused into the renal artery, suppressed decreases in renal blood flow induced by intrarenal arterial injection of angiotensin II (Ang II, 25-100 ng) and norepinephrine (NE, 0.25-1 microgram) in anesthetized dogs. Norepinephrine 214-228 natriuretic peptide A Canis lupus familiaris 0-26 1280593-1 1992 Atrial natriuretic peptide (ANP, 10 and 50 ng/kg per min), infused into the renal artery, suppressed decreases in renal blood flow induced by intrarenal arterial injection of angiotensin II (Ang II, 25-100 ng) and norepinephrine (NE, 0.25-1 microgram) in anesthetized dogs. Norepinephrine 214-228 natriuretic peptide A Canis lupus familiaris 28-31 1385204-1 1992 Recent studies in this laboratory have demonstrated that intramuscular injection of the irreversible acetylcholinesterase (AChE) inhibitor, soman (pinacolylmethylphosphonofluoridate), produces a rapid (1-2 h) and profound depletion (70% of control) of norepinephrine (NE) in the olfactory bulb and forebrain. Norepinephrine 252-266 acetylcholinesterase Rattus norvegicus 101-121 1385204-1 1992 Recent studies in this laboratory have demonstrated that intramuscular injection of the irreversible acetylcholinesterase (AChE) inhibitor, soman (pinacolylmethylphosphonofluoridate), produces a rapid (1-2 h) and profound depletion (70% of control) of norepinephrine (NE) in the olfactory bulb and forebrain. Norepinephrine 252-266 acetylcholinesterase Rattus norvegicus 123-127 1382062-1 1992 Dopamine beta-hydroxylase, the enzyme which converts dopamine to norepinephrine, is expressed in a cell type-restricted pattern in neuroendocrine tissue. Norepinephrine 65-79 dopamine beta-hydroxylase Rattus norvegicus 0-25 1356432-6 1992 These studies indicate that, in addition to the dopamine system, the norepinephrine and serotonin systems also play prominent roles in the activation of zif268 and c-fos by cocaine and amphetamine. Norepinephrine 69-83 early growth response 1 Homo sapiens 153-159 1359604-7 1992 CRH content in the locus coeruleus is particularly increased by stress and may influence norepinephrine neurotransmitter function in this structure. Norepinephrine 89-103 corticotropin releasing hormone Homo sapiens 0-3 1508391-0 1992 Different functional pools of acetylcholinesterase induce changes in rat locus coeruleus noradrenaline metabolism. Norepinephrine 89-102 acetylcholinesterase Rattus norvegicus 30-50 1381830-8 1992 In the temporal artery, NPY did not induce contraction but potentiated the vasoconstrictor response to noradrenaline. Norepinephrine 103-116 neuropeptide Y Homo sapiens 24-27 1313447-3 1992 The rate of recovery of pHi was enhanced threefold by pretreatment (37.5 s) with isoproterenol (K1/2 = 21.5 nM) or norepinephrine (in the presence of phentolamine), and blocked by the beta 1-specific antagonist atenolol, indicating an upregulation of cotransport activity by beta 1-adrenergic stimulation. Norepinephrine 115-129 glucose-6-phosphate isomerase Rattus norvegicus 24-27 1380602-1 1992 Animal experimental evidence suggests that neuropeptide Y (NPY) is coreleased with norepinephrine (NE) from sympathetic nerve endings and is involved in nonadrenergic neurogenic vascular control of skeletal muscle. Norepinephrine 83-97 neuropeptide Y Homo sapiens 43-57 1380602-1 1992 Animal experimental evidence suggests that neuropeptide Y (NPY) is coreleased with norepinephrine (NE) from sympathetic nerve endings and is involved in nonadrenergic neurogenic vascular control of skeletal muscle. Norepinephrine 83-97 neuropeptide Y Homo sapiens 59-62 1582134-8 1992 Plasma noradrenaline fell by 20% (P less than 0.02) and arterial glucose by 3% (P less than 0.005) during the NPY infusion. Norepinephrine 7-20 neuropeptide Y Homo sapiens 110-113 1582134-10 1992 The results also suggest that elevated plasma NPY-levels may be associated with changes in the turnover of noradrenaline and glucose. Norepinephrine 107-120 neuropeptide Y Homo sapiens 46-49 1577991-1 1992 Phenylethanolamine N-methyltransferase (PNMT), the final enzyme in the catecholamine biosynthetic pathway that converts norepinephrine to epinephrine, has been detected in the retinas of various vertebrate species. Norepinephrine 120-134 phenylethanolamine-N-methyltransferase Rattus norvegicus 0-38 1577991-1 1992 Phenylethanolamine N-methyltransferase (PNMT), the final enzyme in the catecholamine biosynthetic pathway that converts norepinephrine to epinephrine, has been detected in the retinas of various vertebrate species. Norepinephrine 120-134 phenylethanolamine-N-methyltransferase Rattus norvegicus 40-44 1635895-3 1992 This reduced norepinephrine release may augment the fall in blood pressure induced by accumulated acetylcholine stimulating muscarinic receptors following cholinesterase inhibition. Norepinephrine 13-27 butyrylcholinesterase Homo sapiens 155-169 1596693-0 1992 Inhibition of neuropeptide Y-induced potentiation of noradrenaline-induced vasoconstriction by PP56 (D-myo-inositol 1,2,6-tris-phosphate). Norepinephrine 53-66 neuropeptide Y Oryctolagus cuniculus 14-28 1596693-4 1992 The potentiating effect of NPY on noradrenaline-induced contraction was present in endothelium-denuded femoral arteries. Norepinephrine 34-47 neuropeptide Y Oryctolagus cuniculus 27-30 1596693-6 1992 The potentiating effect of NPY on noradrenaline-induced contraction was antagonized by PP56 (D-myo-inositol 1,2,6-trisphosphate) in low concentrations (down to 0.1 nM). Norepinephrine 34-47 neuropeptide Y Oryctolagus cuniculus 27-30 1320891-1 1992 Neuropeptide Y, one of the most abundant polypeptides within the nervous system, is co-stored with catecholamines, especially norepinephrine (NE), thus suggesting its possible involvement in pathologies characterized by a noradrenergic impairment. Norepinephrine 126-140 neuropeptide Y Homo sapiens 0-14 15815433-1 1992 Neuropeptide Y (NPY) a potent vasoconstrictor peptide, is co-stored with the classic neurotransmitter noradrenaline (NA) in certain peripheral sympathetic neurons and has been suggested to be a co-transmitter in vascular control. Norepinephrine 102-115 neuropeptide Y Homo sapiens 0-14 15815433-1 1992 Neuropeptide Y (NPY) a potent vasoconstrictor peptide, is co-stored with the classic neurotransmitter noradrenaline (NA) in certain peripheral sympathetic neurons and has been suggested to be a co-transmitter in vascular control. Norepinephrine 102-115 neuropeptide Y Homo sapiens 16-19 1837318-8 1991 The early elevation of pANP correlated with plasma concentrations of both noradrenaline (r = 0.55, n = 27, p less than 0.01) and creatine phosphokinase (r = 0.54, n = 27, p less than 0.01). Norepinephrine 74-87 PILR alpha associated neural protein Homo sapiens 23-27 1786546-1 1991 Noradrenaline-containing nerve terminals within the cat spinal dorsal horn were studied by immunocytochemical localization of dopamine-beta-hydroxylase. Norepinephrine 0-13 dopamine beta-hydroxylase Homo sapiens 126-151 1880809-2 1991 Recently, NPY has also been reported to inhibit the relaxation to noradrenaline in isolated rabbit coronary arteries, but the composition of the Krebs solution described in this study indicated that it contained no magnesium. Norepinephrine 66-79 neuropeptide Y Oryctolagus cuniculus 10-13 2002450-1 1991 We have found that (R,S)-1-(phenylthio)-aminopropane (4a), a synthetic alternate substrate for the terminal enzyme of norepinephrine biosynthesis, dopamine beta-monooxygenase (DBM), is both an indirect sympathomimetic and a potent antihypertensive agent in spontaneously hypertensive rats. Norepinephrine 118-132 dopamine beta-hydroxylase Rattus norvegicus 147-174 1670626-3 1991 Neuropeptide Y (NPY), a 36-amino acid neuropeptide that is colocalized and released with norepinephrine from sympathetic nerves, has already been implicated in inflammatory reactions via modulation of histamine release from mast cells. Norepinephrine 89-103 neuropeptide Y Homo sapiens 0-14 1670626-3 1991 Neuropeptide Y (NPY), a 36-amino acid neuropeptide that is colocalized and released with norepinephrine from sympathetic nerves, has already been implicated in inflammatory reactions via modulation of histamine release from mast cells. Norepinephrine 89-103 neuropeptide Y Homo sapiens 16-19 34767786-6 2021 Similarly, lowest energy conformations of noradrenaline and dopamine generated by docking into flexible beta2 AR models had binding free energies lower than those of best poses in rigid receptor models. Norepinephrine 42-55 adenosine A2a receptor Homo sapiens 104-112 34767786-7 2021 Furthermore, our findings show that L-DOPA and Droxidopa molecules have binding affinities comparable to those predicted for adrenaline, noradrenaline, and dopamine, which are consistent with previous experimental and computational findings and supported by the MD simulations of beta2AR-ligand complexes performed here. Norepinephrine 137-150 adenosine A2a receptor Homo sapiens 280-287 34970413-5 2021 The norepinephrine (NE) triggered beta 2-AR to activate the FOXO1/NF-kappaB pathway, which induced endometrial inflammation. Norepinephrine 4-18 adenosine A2a receptor Homo sapiens 34-43 34938289-10 2021 Among critically ill patients, MCP-1 predicted the duration of mechanical ventilation, highest norepinephrine dose administered, and length of intensive care stay. Norepinephrine 95-109 C-C motif chemokine ligand 2 Homo sapiens 31-36 34772699-5 2021 We report that norepinephrine treatment dramatically altered moMF cytokine production, whereas DCs were unresponsive to norepinephrine and critically lack beta2-adrenergic receptor expression. Norepinephrine 15-29 adrenergic receptor, beta 2 Mus musculus 155-180 34713714-8 2021 The effects of norepinephrine on the expression of GLP-1R and neprilysin in kidney epithelial LLC-PK1 cells were also examined. Norepinephrine 15-29 glucagon like peptide 1 receptor Sus scrofa 51-57 34870059-13 2021 Histological findings in our case give a possible hypothesis that the mechanism underlying a dopamine-secreting pheochromocytoma is associated with immature catecholamine vesicles in which dopamine beta-hydroxylase is localized, thus resulting in inhibited conversion from dopamine to norepinephrine. Norepinephrine 285-299 dopamine beta-hydroxylase Homo sapiens 189-214 34074423-6 2021 The linearity was 0.25-500 ng mL-1 for norepinephrine, epinephrine, dopamine, normetanephrine 3-methoxytyramine, serotonin, histamine, and 0.1-500 ng mL-1 for metanephrine. Norepinephrine 39-53 L1 cell adhesion molecule Mus musculus 30-34 34425806-0 2021 Norepinephrine modulates IL-1beta-induced catabolic response of human chondrocytes. Norepinephrine 0-14 interleukin 1 alpha Homo sapiens 25-33 34485365-6 2021 In white adipocytes, green tea compounds decreased both basal and norepinephrine-induced UCP1 mRNA levels, and this was associated with the suppression of cell differentiation, indicated by reduced lipogenic gene expression and lipid accumulation. Norepinephrine 66-80 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 27-30 34099360-8 2021 Via its inhibitory and excitatory effects on neurons and microglia, noradrenaline sometimes prevents and sometimes accelerates the production and accumulation of amyloid-beta and tau in various brain regions. Norepinephrine 68-81 microtubule associated protein tau Homo sapiens 179-182 35045380-1 2022 Abnormally phosphorylated tau, an indicator of Alzheimer"s disease, accumulates in the first decades of life in the locus coeruleus (LC), the brain"s main noradrenaline supply. Norepinephrine 155-168 microtubule associated protein tau Homo sapiens 26-29 35327387-6 2022 UCP1 expression correlated only with norepinephrine levels and its metabolite. Norepinephrine 37-51 uncoupling protein 1 Homo sapiens 0-4 35327387-10 2022 CONCLUSION: We demonstrate signs of UCP1-dependent norepinephrine-induced thermogenesis connected with higher expression of DIO2, PPARGC1A, CEBPB and PRDM16 in retroperitoneal VAT of PPGL and its relations to circulating HDLc and triglycerides levels. Norepinephrine 51-65 uncoupling protein 1 Homo sapiens 36-40 35327387-10 2022 CONCLUSION: We demonstrate signs of UCP1-dependent norepinephrine-induced thermogenesis connected with higher expression of DIO2, PPARGC1A, CEBPB and PRDM16 in retroperitoneal VAT of PPGL and its relations to circulating HDLc and triglycerides levels. Norepinephrine 51-65 iodothyronine deiodinase 2 Homo sapiens 124-128 35210489-5 2022 Our ex vivo efflux experiments reveal that the NE transporter (NET) blocker desipramine elevates both norepinephrine (NE) and dopamine (DA), but not 5-HT levels, in PFC tissue slices from wild-type (WT) and DAT-KO, but not NET-KO mice. Norepinephrine 102-116 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 47-61 2603996-5 1989 Norepinephrine (10(-9)-3 x 10(-4) M) caused dose-dependent contraction that was blocked by phentolamine and by the inhibitors of cyclooxygenase but was not modified by endothelium removal. Norepinephrine 0-14 prostaglandin-endoperoxide synthase 1 Canis lupus familiaris 129-143 2607250-0 1989 Direct pituitary inhibition of prolactin secretion by dopamine and noradrenaline in sheep. Norepinephrine 67-80 prolactin Ovis aries 31-40 2607250-1 1989 The effects of dopamine, noradrenaline and 3,4-dihydroxyphenylacetic acid (DOPAC) on the release of prolactin were examined in ovariectomized ewes. Norepinephrine 25-38 prolactin Ovis aries 100-109 2607250-11 1989 We conclude that the secretion of prolactin from the pituitary gland is under dual inhibitory regulation by both dopamine and noradrenaline in the sheep. Norepinephrine 126-139 prolactin Ovis aries 34-43 2576431-1 1989 The effects of the beta 1-adrenoceptor blocking drug atenolol and the beta 2-adrenoceptor blocking drug ICI 118551 (ICI, Melbourne, Australia) on noradrenaline release and blood pressure were investigated using the pithed rat, which was subjected to continuous electrical stimulation of the spinal sympathetic outflow (pulses at 3 Hz). Norepinephrine 146-159 adrenoceptor beta 2 Rattus norvegicus 70-89 2553251-2 1989 Epinephrine (Epi) and norepinephrine (NE) activated AH130 adenylate cyclase about half as much as isoproterenol (IPN) but equaled IPN after treatment with the alpha-antagonist phentolamine or islet-activating protein (IAP). Norepinephrine 22-36 magnesium transporter 1 Rattus norvegicus 192-216 2553251-2 1989 Epinephrine (Epi) and norepinephrine (NE) activated AH130 adenylate cyclase about half as much as isoproterenol (IPN) but equaled IPN after treatment with the alpha-antagonist phentolamine or islet-activating protein (IAP). Norepinephrine 22-36 magnesium transporter 1 Rattus norvegicus 218-221 2574070-4 1989 However, there was a significantly stronger depression of glutamate-evoked activity of CA1 pyramidal neurons by noradrenaline in the clonidine-treated rats. Norepinephrine 112-125 carbonic anhydrase 1 Rattus norvegicus 87-90 2781292-5 1989 In addition, glucocorticoids attenuated the norepinephrine-induced blockade of action potential accommodation in CA1 neurons. Norepinephrine 44-58 carbonic anhydrase 1 Rattus norvegicus 113-116 2570461-3 1989 Exposure of eukaryotic cells transfected with this gene to adrenaline or noradrenaline promotes the accumulation of adenosine 3",5"-monophosphate; only 2 of 11 classical beta-AR blockers efficiently inhibited this effect, whereas two others behaved as beta 3-AR agonists. Norepinephrine 73-86 adrenoceptor beta 3 Homo sapiens 252-261 2583236-3 1989 Conditions that increase the biophase concentration of norepinephrine, longer stimulation trains or application of yohimbine, decreased the potentiation by NPY, although in the presence of cocaine potentiation by NPY was unchanged. Norepinephrine 55-69 neuropeptide Y Oryctolagus cuniculus 156-159 2764101-6 1989 NPY (10(-10) to 10(-6) M) exerted a direct vasoconstrictory effect on small arteries dissected from the cervix and an additive effect of NPY and norepinephrine responses was observed. Norepinephrine 145-159 neuropeptide Y Homo sapiens 0-3 2668503-0 1989 Effects of neuropeptide Y on the response of isolated blood vessels to norepinephrine and sympathetic field stimulation. Norepinephrine 71-85 neuropeptide Y Oryctolagus cuniculus 11-25 2668503-8 1989 NPY also produced an endothelium-dependent potentiation of the constrictor response to exogenous norepinephrine in superfused segments of both ear artery and saphenous vein. Norepinephrine 97-111 neuropeptide Y Oryctolagus cuniculus 0-3 2817346-1 1989 The monoamine oxidase A metabolite of noradrenaline, 3,4-dihydroxyphenylglycolaldehyde, is the precursor of 3,4-dihydroxymandelic acid, and 3,4-dihydroxyphenylglycol, metabolites of noradrenaline. Norepinephrine 38-51 monoamine oxidase A Homo sapiens 4-23 2817346-1 1989 The monoamine oxidase A metabolite of noradrenaline, 3,4-dihydroxyphenylglycolaldehyde, is the precursor of 3,4-dihydroxymandelic acid, and 3,4-dihydroxyphenylglycol, metabolites of noradrenaline. Norepinephrine 182-195 monoamine oxidase A Homo sapiens 4-23 2570849-0 1989 Inhibition of Na+,K+-ATPase activity by phospholipase A2 and several lysophospholipids: possible role of phospholipase A2 in noradrenaline release from cerebral cortical synaptosomes. Norepinephrine 125-138 phospholipase A2 group IB Rattus norvegicus 105-121 2472177-0 1989 CSF norepinephrine in schizophrenia is elevated prior to relapse after haloperidol withdrawal. Norepinephrine 4-18 colony stimulating factor 2 Homo sapiens 0-3 2472177-5 1989 CSF norepinephrine (NE), 3-methoxy-4-hydroxyphenylglycol (MHPG), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5 HIAA) concentrations were measured with high-pressure liquid chromatography (HPLC). Norepinephrine 4-18 colony stimulating factor 2 Homo sapiens 0-3 2743742-1 1989 The purpose of the present study was to evaluate whether neuropeptide Y, which coexists with noradrenaline in sympathetic nerves, may be released upon cigarette smoking. Norepinephrine 93-106 neuropeptide Y Homo sapiens 57-71 2743742-4 1989 Systemic plasma levels of noradrenaline and neuropeptide Y were significantly elevated after 3 and 5 min of smoking, respectively, and reached maximal values (neuropeptide Y from 32 +/- 4 to 49 +/- 7 pmol l-1, and noradrenaline from 0.72 +/- 0.16 to 1.8 +/- 0.44 nmol l-1) 2-5 min after the smoking period. Norepinephrine 26-39 neuropeptide Y Homo sapiens 159-173 2743742-4 1989 Systemic plasma levels of noradrenaline and neuropeptide Y were significantly elevated after 3 and 5 min of smoking, respectively, and reached maximal values (neuropeptide Y from 32 +/- 4 to 49 +/- 7 pmol l-1, and noradrenaline from 0.72 +/- 0.16 to 1.8 +/- 0.44 nmol l-1) 2-5 min after the smoking period. Norepinephrine 214-227 neuropeptide Y Homo sapiens 44-58 2702581-6 1989 This suggests a dopamine-norepinephrine pathway block, which supports previous reports of deficiency of dopamine beta-hydroxylase activity in some neuroblastomas. Norepinephrine 25-39 dopamine beta-hydroxylase Homo sapiens 104-129 2707360-1 1989 Noradrenergic input to the rat substantia innominata (SI) was analyzed in this study by immunocytochemical localization of dopamine beta-hydroxylase (DBH), the synthetic enzyme for noradrenaline. Norepinephrine 181-194 dopamine beta-hydroxylase Rattus norvegicus 123-148 2707360-1 1989 Noradrenergic input to the rat substantia innominata (SI) was analyzed in this study by immunocytochemical localization of dopamine beta-hydroxylase (DBH), the synthetic enzyme for noradrenaline. Norepinephrine 181-194 dopamine beta-hydroxylase Rattus norvegicus 150-153 2566715-7 1989 Noradrenaline excites supraoptic neurons and leads to phasic firing through an alpha-1 mechanism and decreased K+-conductance. Norepinephrine 0-13 adrenoceptor alpha 1D Homo sapiens 79-86 2705532-1 1989 Neuropeptide Y (NPY) is a potent vasoconstrictor peptide contained in sympathetic nerve terminals and is co-released with norepinephrine. Norepinephrine 122-136 neuropeptide Y Homo sapiens 0-14 2705532-1 1989 Neuropeptide Y (NPY) is a potent vasoconstrictor peptide contained in sympathetic nerve terminals and is co-released with norepinephrine. Norepinephrine 122-136 neuropeptide Y Homo sapiens 16-19 2708265-1 1989 It was the purpose of this investigation to examine any age-related changes in norepinephrine turnover (NEt) in four tissues at rest and during exercise. Norepinephrine 79-93 solute carrier family 6 member 2 Rattus norvegicus 104-107 2706916-1 1989 Neuropeptide Y (NPY) has recently been shown be co-released with noradrenaline (NA) from sympathetic nerves and to cause arterial vasoconstriction in experimental animals and man. Norepinephrine 65-78 neuropeptide Y Homo sapiens 16-19 2924106-3 1989 By light microscopy, varicose processes showing intense PNMT-like immunoreactivity (LI) were seen throughout the neuropil surrounding neuronal perikarya which in adjacent sections were shown to contain immunoreactivity for the noradrenaline synthesizing enzyme, dopamine-beta-hydroxylase. Norepinephrine 227-240 phenylethanolamine-N-methyltransferase Rattus norvegicus 56-60 2644003-0 1989 Limited responsiveness of LHRH neurons to norepinephrine may account for failure of locus coeruleus or medullary A1 electrical stimulation to increase plasma LH in estrogen-treated ovariectomized rats. Norepinephrine 42-56 gonadotropin releasing hormone 1 Rattus norvegicus 26-30 2563197-4 1989 Norepinephrine and acetylcholine increased immunoreactive corticotropin-releasing factor release into the culture medium in a dose-related manner. Norepinephrine 0-14 corticotropin releasing hormone Homo sapiens 58-88 2910096-3 1989 RESULTS: Under resting conditions, plasma NPY and norepinephrine levels were elevated in patients with CHF compared with control subjects (551 +/- 48 pg/ml versus 311 +/- 22 pg/ml, p less than or equal to 0.001 for NPY, and 306 +/- 73 pg/ml versus 124 +/- 22 pg/ml, p less than or equal to 0.02 for norepinephrine). Norepinephrine 299-313 neuropeptide Y Homo sapiens 42-45 2910096-4 1989 Plasma NPY correlated better with plasma norepinephrine than with epinephrine, indicating its origin from sympathetic nerve terminals. Norepinephrine 41-55 neuropeptide Y Homo sapiens 7-10 2743605-1 1989 Neuropeptide Y (NPY) coexists with noradrenaline in postganglionic sympathetic neurons and with noradrenaline and adrenaline in the central nervous system. Norepinephrine 35-48 neuropeptide Y Homo sapiens 0-14 2743605-1 1989 Neuropeptide Y (NPY) coexists with noradrenaline in postganglionic sympathetic neurons and with noradrenaline and adrenaline in the central nervous system. Norepinephrine 35-48 neuropeptide Y Homo sapiens 16-19 2743605-1 1989 Neuropeptide Y (NPY) coexists with noradrenaline in postganglionic sympathetic neurons and with noradrenaline and adrenaline in the central nervous system. Norepinephrine 96-109 neuropeptide Y Homo sapiens 0-14 2743605-1 1989 Neuropeptide Y (NPY) coexists with noradrenaline in postganglionic sympathetic neurons and with noradrenaline and adrenaline in the central nervous system. Norepinephrine 96-109 neuropeptide Y Homo sapiens 16-19 2565245-0 1989 Evidence for the occurrence of an enkephalin-like peptide in adrenaline and noradrenaline neurons of the rat medulla oblongata. Norepinephrine 76-89 proenkephalin Rattus norvegicus 34-44 2545512-2 1989 Neuropeptide Y (NPY) potentiated the contractile responses induced by electrical transmural stimulation, noradrenaline and KCl in the rabbit mesenteric artery. Norepinephrine 105-118 neuropeptide Y Oryctolagus cuniculus 0-14 2545512-2 1989 Neuropeptide Y (NPY) potentiated the contractile responses induced by electrical transmural stimulation, noradrenaline and KCl in the rabbit mesenteric artery. Norepinephrine 105-118 neuropeptide Y Oryctolagus cuniculus 16-19 2545512-4 1989 In preparations treated with noradrenaline or KCl in Ca2+ free medium, NPY also potentiated the contractile response induced by resupplementation of Ca2+. Norepinephrine 29-42 neuropeptide Y Oryctolagus cuniculus 71-74 2468936-3 1989 After exposure of cerebral arteries to 1.5 nM NPY, the potencies of norepinephrine (NE) and histamine in causing contraction were increased by approximately twofold, with no change in maximal contraction. Norepinephrine 68-82 neuropeptide Y Oryctolagus cuniculus 46-49 2566929-13 1989 These results are consistent with a beta 1-adrenoceptor-mediated relaxation caused by (-)-noradrenaline released from sympathetic nerve endings at low stimulation frequencies. Norepinephrine 86-103 adrenoceptor beta 1 Bos taurus 36-55 2905622-3 1988 The present electrophysiological study was undertaken to characterize the adrenoceptor mediating the suppressant effect of microiontophoretically applied norepinephrine (NE) on CA1 and CA3 dorsal hippocampus pyramidal neurons of the rat. Norepinephrine 154-168 carbonic anhydrase 1 Rattus norvegicus 177-180 3253235-5 1988 During cross-country skiing, the average noradrenaline elimination (1166 pmol.min-1) was about 150% higher and the average adrenaline elimination (243 pmol.min-1) about 30% lower than during ski-flying. Norepinephrine 41-54 SKI proto-oncogene Homo sapiens 21-24 3253235-6 1988 The noradrenaline-adrenaline ratio was about 4.8 in cross-country skiing and 1.3-1.5 in ski-flying. Norepinephrine 4-17 SKI proto-oncogene Homo sapiens 66-69 2853756-4 1988 Exogenous neuropeptide Y reduced nerve stimulation-evoked noradrenaline overflow, possibly through a prejunctional mechanism, and caused dose-dependent vasoconstriction. Norepinephrine 58-71 neuropeptide Y Homo sapiens 10-24 3241208-3 1988 The ability of neuropeptide Y to potentiate the constrictor response to noradrenaline in the ear artery was also dependent on the presence of an intact endothelium. Norepinephrine 72-85 neuropeptide Y Oryctolagus cuniculus 15-29 3240025-2 1988 In addition, we have shown in vitro that these compounds are facile substrates for dopamine beta-hydroxylase, the terminal enzyme of norepinephrine synthesis. Norepinephrine 133-147 dopamine beta-hydroxylase Rattus norvegicus 83-108 3196916-4 1988 The effects of porcine NPY on norepinephrine-induced contraction of rabbit cerebral arteries were also studied in vitro. Norepinephrine 30-44 neuropeptide Y Oryctolagus cuniculus 23-26 3196916-5 1988 NPY (1.2 nM) caused a 3-fold potentiation of norepinephrine-induced contraction of cerebral arteries. Norepinephrine 45-59 neuropeptide Y Oryctolagus cuniculus 0-3 3196916-10 1988 In addition, NPY in CSF can potentiate the vasoconstrictor effect of norepinephrine which may contribute to the development of cerebral vasospasm. Norepinephrine 69-83 neuropeptide Y Oryctolagus cuniculus 13-16 3146034-9 1988 In 39 and 20% of the 119 neurons tested, the norepinephrine responses were potentiated and attenuated, respectively, by luteinizing hormone-releasing hormone. Norepinephrine 45-59 gonadotropin releasing hormone 1 Rattus norvegicus 120-157 2843407-6 1988 (-)-Norepinephrine, the unspecific beta-adrenergic agonist (-)-isoproterenol, and the beta 2-specific agonist terbutaline mimicked the effect of epinephrine on LDL-receptor activity. Norepinephrine 0-18 low density lipoprotein receptor Homo sapiens 160-172 3421335-2 1988 GRP injected into the third cerebral ventricle significantly (P less than 0.01) increased plasma epinephrine but not norepinephrine concentrations. Norepinephrine 117-131 gastrin releasing peptide Canis lupus familiaris 0-3 2899914-6 1988 Norepinephrine (mixed alpha 1- and alpha 2-agonist) significantly increased intestinal absorption and vascular resistance. Norepinephrine 0-14 adrenoceptor alpha 1D Homo sapiens 22-42 3407677-8 1988 The vasoconstriction produced by noradrenaline was potentiated by subthreshold concentrations of NPY. Norepinephrine 33-46 neuropeptide Y Homo sapiens 97-100 3262452-4 1988 Incubation of rat aortas with human monocyte-derived interleukin 1 or recombinant human tumor necrosis factor resulted in diminished aortic contraction and sensitivity to norepinephrine, and gel filtration of medium conditioned by endotoxin-stimulated macrophages yielded suppressive activity at a molecular weight equivalent to interleukin 1 and tumor necrosis factor. Norepinephrine 171-185 interleukin 1 alpha Homo sapiens 53-66 2898856-0 1988 Blood levels, clearance rates and effects of epinephrine and norepinephrine on insulin and metabolites during alpha- and beta-adrenergic blockade in cattle in vivo, and in vitro degradation of dopamine in bovine blood. Norepinephrine 61-75 insulin Bos taurus 79-86 2898856-4 1988 alpha- and beta-adrenergic blockade markedly modified insulin, glucose and non-esterified fatty acid responses to epinephrine and norepinephrine. Norepinephrine 130-144 insulin Bos taurus 54-61 2899848-8 1988 Results of this study support the hypothesis that epinephrine and/or norepinephrine regulate the release of ACTH and vasopressin via alpha-1- and alpha-2-adrenergic receptors associated with CRF- and VP-containing somata within the PVN. Norepinephrine 69-83 adrenoceptor alpha 1D Homo sapiens 133-141 3285962-1 1988 The effect of age on norepinephrine (NE) stimulation of luteinizing hormone-releasing hormone (LH-RH) secretion from preoptic area-mediobasal hypothalamic (POA-MBH) explants was examined in the present study. Norepinephrine 21-35 gonadotropin releasing hormone 1 Rattus norvegicus 95-100 3358538-2 1988 It is postulated that since hypothalamic norepinephrine (NE) is known to inhibit corticotropin-releasing hormone (CRH), an increase in brain NE as measured by its metabolite 3-methoxy-4-hydroxy-phenylglycol (MHPG) could reflect the depression of the hypothalamic-pituitary-adrenal (HPA) axis as measured by urinary cortisol levels. Norepinephrine 41-55 corticotropin releasing hormone Homo sapiens 81-112 3358538-2 1988 It is postulated that since hypothalamic norepinephrine (NE) is known to inhibit corticotropin-releasing hormone (CRH), an increase in brain NE as measured by its metabolite 3-methoxy-4-hydroxy-phenylglycol (MHPG) could reflect the depression of the hypothalamic-pituitary-adrenal (HPA) axis as measured by urinary cortisol levels. Norepinephrine 41-55 corticotropin releasing hormone Homo sapiens 114-117 2843779-1 1988 Norepinephrine (NE) has been shown to have a biphasic effect on evoked potentials in the CA1 region of the hippocampus of the rat in vitro, with a beta receptor mediating an increase and an alpha receptor eliciting a decrease in the amplitude of the population spike. Norepinephrine 0-14 carbonic anhydrase 1 Rattus norvegicus 89-92 2834010-1 1988 The effects of norepinephrine (NE) on inhibitory synaptic potentials were studied on CA1 pyramidal neurons in the hippocampal slice in vitro. Norepinephrine 15-29 carbonic anhydrase 1 Rattus norvegicus 85-88 2834010-2 1988 Norepinephrine caused the appearance of multiple population spikes in the CA1 region of the hippocampal slice, reminiscent of the actions of gamma-aminobutyric acid (GABA) antagonists. Norepinephrine 0-14 carbonic anhydrase 1 Rattus norvegicus 74-77 2834003-1 1988 Prostaglandin E2 (PGE2) has been implicated as a mediator of norepinephrine-induced luteinizing hormone-releasing hormone (LHRH) release from the hypothalamus. Norepinephrine 61-75 gonadotropin releasing hormone 1 Rattus norvegicus 84-121 2834003-1 1988 Prostaglandin E2 (PGE2) has been implicated as a mediator of norepinephrine-induced luteinizing hormone-releasing hormone (LHRH) release from the hypothalamus. Norepinephrine 61-75 gonadotropin releasing hormone 1 Rattus norvegicus 123-127 3169195-4 1988 Bath application of noradrenaline, isoproterenol and histamine or a transient exposure to Mg++-free medium caused a long lasting increase in extracellularly recorded population spikes induced in CA1 by electrical stimulation of stratum radiatum. Norepinephrine 20-33 carbonic anhydrase 1 Mus musculus 195-198 20501291-3 1988 The role of this glutamate receptor site was investigated by studying the effects of select glutamate receptor agonists and antagonists and of ?-aminobutyric acid on the basal- and on the norepinephrine-stimulated activity of arylalkylamine N-acetyltransferase in rat pineal glands that were incubated in Dulbecco"s Modified Eagle Medium at 37 degrees C for 20 min in an atmosphere of 5% CO(2)/95% O(2). Norepinephrine 188-202 aralkylamine N-acetyltransferase Rattus norvegicus 226-260 3233105-2 1988 Because dopamine-beta-hydroxylase, an essential enzyme in norepinephrine biosynthesis, is copper-dependent, we studied norepinephrine metabolism in vivo in 5 affected children. Norepinephrine 58-72 dopamine beta-hydroxylase Homo sapiens 8-33 3233105-2 1988 Because dopamine-beta-hydroxylase, an essential enzyme in norepinephrine biosynthesis, is copper-dependent, we studied norepinephrine metabolism in vivo in 5 affected children. Norepinephrine 119-133 dopamine beta-hydroxylase Homo sapiens 8-33 3125948-0 1987 Noradrenaline neuron plasticity in developing rat brain: effects of neonatal 6-hydroxydopamine demonstrated by dopamine-beta-hydroxylase immunocytochemistry. Norepinephrine 0-13 dopamine beta-hydroxylase Rattus norvegicus 111-136 3509070-1 1987 Neuropeptide Y (a recently discovered brain peptide that is colocalized with norepinephrine within some adrenergic central nervous system neurons) was measured in the cerebrospinal fluid (CSF) from patients with major affective disorder, chronic schizophrenia, and in normal volunteers. Norepinephrine 77-91 neuropeptide Y Homo sapiens 0-14 2890806-0 1987 Endogenous restoration of noradrenaline by precursor therapy in dopamine-beta-hydroxylase deficiency. Norepinephrine 26-39 dopamine beta-hydroxylase Homo sapiens 64-89 2890807-0 1987 Effect of unnatural noradrenaline precursor on sympathetic control and orthostatic hypotension in dopamine-beta-hydroxylase deficiency. Norepinephrine 20-33 dopamine beta-hydroxylase Homo sapiens 98-123 2890807-1 1987 A patient with severe orthostatic hypotension due to dopamine-beta-hydroxylase deficiency was treated with the unnatural aminoacid D,L-threo-3,4-dihydroxyphenylserine (DOPS) in the hope that it would serve as a substrate of aromatic-L-aminoacid decarboxylase to produce (-)-noradrenaline. Norepinephrine 270-287 dopamine beta-hydroxylase Homo sapiens 53-78 3691657-3 1987 Turnover in the left ventricles, as estimated by the decrease of noradrenaline under dopamine beta-hydroxylase inhibition with bis-(4-methyl-1-homo-piperazinyl-thiocarbonyl)-disulfide (FLA-63), was unaffected by ligation whether in untreated, adrenalectomized, or hexamethonium-treated rats. Norepinephrine 65-78 dopamine beta-hydroxylase Rattus norvegicus 85-110 2894798-1 1987 Ornithine decarboxylase activity of rat lung was induced by s.c. injection of acetylcholine, norepinephrine, epinephrine, dopamine, serotonin, vasopressin, angiotensin II, and adrenocorticotropic hormone, but not by gonadotropin, aldosterone, corticosterone or hydrocortisone. Norepinephrine 93-107 ornithine decarboxylase 1 Rattus norvegicus 0-23 2960721-0 1987 CSF dopamine increased in depression: CSF dopamine, noradrenaline and their metabolites in depressed patients and in controls. Norepinephrine 52-65 colony stimulating factor 2 Homo sapiens 0-3 2890722-3 1987 Previous work has shown that norepinephrine administration inhibits melatonin biosynthesis, as measured by the activity of the enzyme serotonin N-acetyltransferase. Norepinephrine 29-43 aralkylamine N-acetyltransferase Gallus gallus 134-163 3441159-2 1987 The mean CSF concentrations of noradrenaline and dopamine were found to be 123 +/- 48 pg/ml and 10 +/- 6 pg/ml, respectively, in 14 drug-free subjects. Norepinephrine 31-44 colony stimulating factor 2 Homo sapiens 9-12 3441159-5 1987 As a preliminary investigation, signs of seasonal variation in the CSF concentration of noradrenaline and dopamine were registered in 4 female subjects. Norepinephrine 88-101 colony stimulating factor 2 Homo sapiens 67-70 3497798-0 1987 Facilitation of immunoreactive corticotropin-releasing factor secretion into the hypophysial-portal circulation after activation of catecholaminergic pathways or central norepinephrine injection. Norepinephrine 170-184 corticotropin releasing hormone Homo sapiens 31-61 3683592-6 1987 The kCOMT values for all four catecholamines, (-)-noradrenaline, dopamine, (-)-adrenaline and (+/-)-isoprenaline exhibit a range from 0.24 to 0.78 min-1; the metabolism of the catecholamines by the COMT differs: (-)-noradrenaline = dopamine less than (-)-adrenaline less than (+/-)-isoprenaline. Norepinephrine 46-63 catechol-O-methyltransferase Rattus norvegicus 5-9 2820553-4 1987 These results suggest that the effects of ascorbic acid on the in vitro release of LHRH are mediated by endogenous norepinephrine. Norepinephrine 115-129 gonadotropin releasing hormone 1 Rattus norvegicus 83-87 2442533-3 1987 Following exposure of coronary arteries to 30 nM NPY, the potencies of norepinephrine (in the presence of 3 microM timolol) and histamine in causing contraction were increased twofold, with no change in maximal contraction. Norepinephrine 71-85 neuropeptide Y Oryctolagus cuniculus 49-52 2442533-4 1987 After half-maximal contraction of coronary arteries with histamine and addition of 30 nM NPY, relaxation produced by norepinephrine (in the presence of 3 microM phentolamine), adenosine, and acetylcholine was inhibited. Norepinephrine 117-131 neuropeptide Y Oryctolagus cuniculus 89-92 2824105-4 1987 Under in vitro conditions activation of alpha 1-, alpha 2-, prostaglandin, adenosine, dopamine and serotonin receptors inhibits noradrenaline release from the kidney. Norepinephrine 128-141 adrenoceptor alpha 1D Homo sapiens 40-57 2824105-7 1987 Moreover, neuronally released noradrenaline inhibits its own release through activation of both prejunctional alpha 1- and alpha 2-adrenoceptors. Norepinephrine 30-43 adrenoceptor alpha 1D Homo sapiens 110-117 2824105-9 1987 Locally produced PGE2, which is formed and released via stimulation of postjunctional alpha 1-adrenoceptors, as well as adenosine, released from postjunctional sites by renal nerve stimulation (RNS), seems to inhibit noradrenaline release through their specific prejunctional receptor systems. Norepinephrine 217-230 adrenoceptor alpha 1D Homo sapiens 86-93 3100285-1 1987 Ca2+-dependent and TSH-, norepinephrine (NE)-, and A23187-induced iodide (I-) efflux from FRTL-5 rat thyroid cells is inhibited by quinacrine and trifluoroperazine, agents that inhibit phospholipase A2 activity. Norepinephrine 25-39 phospholipase A2 group IB Rattus norvegicus 185-201 3611599-1 1987 In agreement with the inhibition of dopamine-beta-hydroxylase by exposure to CS2, the extension of exposure time from 4 to 16 h increased dopamine concentrations in the hypothalmus and adrenals, and decreased noradrenaline concentration in the hypothalmus. Norepinephrine 209-222 dopamine beta-hydroxylase Rattus norvegicus 36-61 3304727-3 1987 An alternative approach to stimulating dopamine receptors, while at the same time blunting sympathetic nervous system activity, would be by inhibiting the enzyme dopamine beta-hydroxylase (D beta H), thus increasing the cardiovascular and renal ratio of dopamine to norepinephrine. Norepinephrine 266-280 dopamine beta-hydroxylase Rattus norvegicus 162-187 2884200-8 1987 In addition to vascular noradrenaline-containing fibers as described earlier the study shows parenchymal DBH-immunoreactive fibers in the neural lobe, suggesting a local role for noradrenaline in this lobe. Norepinephrine 179-192 dopamine beta-hydroxylase Rattus norvegicus 105-108 2455181-6 1987 Cardiac tissues were weighed and subsequently analyzed for activities of tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH), two enzymes catalyzing the biosynthesis of catecholamines (CAs), and of choline acetyltransferase (CAT), a marker of parasympathetic activity, as well as for norepinephrine (NE). Norepinephrine 294-308 dopamine beta-hydroxylase Cavia porcellus 130-133 2455193-2 1987 Neuropeptide Y is stored in large dense-cored vesicles and coreleased with noradrenaline (NA) from postganglionic, sympathetic nerves, and with adrenaline (ADR) from the adrenal medulla. Norepinephrine 75-88 neuropeptide Y Homo sapiens 0-14 2455195-4 1987 Examples include the interactions of neuropeptide Y (NPY) with noradrenaline (NA) and adenosine 5"-triphosphate (ATP) released from some sympathetic nerves; vasoactive intestinal polypeptide (VIP) with acetylcholine (ACh) released from some parasympathetic nerves; and NPY and 5-hydroxytryptamine (5-HT) released from intracardiac neurones supplying coronary vessels. Norepinephrine 63-76 neuropeptide Y Homo sapiens 37-51 2455195-4 1987 Examples include the interactions of neuropeptide Y (NPY) with noradrenaline (NA) and adenosine 5"-triphosphate (ATP) released from some sympathetic nerves; vasoactive intestinal polypeptide (VIP) with acetylcholine (ACh) released from some parasympathetic nerves; and NPY and 5-hydroxytryptamine (5-HT) released from intracardiac neurones supplying coronary vessels. Norepinephrine 63-76 neuropeptide Y Homo sapiens 53-56 3320555-3 1987 We have found that the diurnal pattern of norepinephrine turnover is altered in critical hypothalamic areas known to regulate the release of LHRH. Norepinephrine 42-56 gonadotropin releasing hormone 1 Rattus norvegicus 141-145 3099112-7 1986 It seems probable that ascorbate may enhance the activity of endogenous norepinephrine in the MBH and, thereby, lead to increased release of LHRH. Norepinephrine 72-86 gonadotropin releasing hormone 1 Rattus norvegicus 141-145 3492236-1 1986 Corticotropin-releasing factor (CRF) has been microinjected into different brain areas in an effort to characterize specific sites of action of this peptide to influence the concentrations of norepinephrine in plasma. Norepinephrine 192-206 corticotropin releasing hormone Homo sapiens 0-30 3777218-1 1986 Fetal lambs treated with sheep anti-mouse nerve growth factor antibodies (anti-NGF) at 80 days gestation subsequently showed a diminished cardiovascular response to intravenous infusion of tyramine (1 mg/min over 10 min) and no significant change in plasma norepinephrine concentrations as measured by reversed-phase high-pressure liquid chromatography and electrochemical detection. Norepinephrine 257-271 beta-nerve growth factor Ovis aries 79-82 2431650-2 1986 Pharmacological experiments on isolated temporal artery segments revealed that NPY potentiated the vasoconstrictor responses to noradrenaline, but had no vasoconstrictor ability or only a small vasoconstrictor ability per se. Norepinephrine 128-141 neuropeptide Y Homo sapiens 79-82 3783085-2 1986 Various inhibitors of phenylethanolamine N-methyltransferase (PNMT), the enzyme which catalyses the conversion of noradrenaline to adrenaline, were administered to freely moving ovariectomized rats bearing an atrial cannula. Norepinephrine 114-127 phenylethanolamine-N-methyltransferase Rattus norvegicus 22-60 3783085-2 1986 Various inhibitors of phenylethanolamine N-methyltransferase (PNMT), the enzyme which catalyses the conversion of noradrenaline to adrenaline, were administered to freely moving ovariectomized rats bearing an atrial cannula. Norepinephrine 114-127 phenylethanolamine-N-methyltransferase Rattus norvegicus 62-66 3024031-16 1986 Angiotensin II, synthesized in response to beta 2-adrenoceptor activation, probably stimulates angiotensin receptors on the noradrenergic nerves, leading to an increase in noradrenaline release. Norepinephrine 172-185 adrenoceptor beta 2 Rattus norvegicus 43-62 3755439-1 1986 Neuropeptide Y (NPY) has recently been reported to coexist with noradrenaline (NA) in central as well as peripheral noradrenergic nerves. Norepinephrine 64-77 neuropeptide Y Homo sapiens 0-14 3755439-1 1986 Neuropeptide Y (NPY) has recently been reported to coexist with noradrenaline (NA) in central as well as peripheral noradrenergic nerves. Norepinephrine 64-77 neuropeptide Y Homo sapiens 16-19 2426539-5 1986 Hypothalamic levels of norepinephrine were decreased during hypoxia [(inhibition of TH, MAO, and dopamine beta-hydroxylase (DBH)]. Norepinephrine 23-37 dopamine beta-hydroxylase Rattus norvegicus 97-122 2426539-5 1986 Hypothalamic levels of norepinephrine were decreased during hypoxia [(inhibition of TH, MAO, and dopamine beta-hydroxylase (DBH)]. Norepinephrine 23-37 dopamine beta-hydroxylase Rattus norvegicus 124-127 3755659-1 1986 Neuropeptide Y (NPY) is colocalised with noradrenaline in post-ganglionic sympathetic neurons. Norepinephrine 41-54 neuropeptide Y Homo sapiens 0-14 3755659-1 1986 Neuropeptide Y (NPY) is colocalised with noradrenaline in post-ganglionic sympathetic neurons. Norepinephrine 41-54 neuropeptide Y Homo sapiens 16-19 3755659-7 1986 The increase in NPY correlated with the increase in noradrenaline, suggesting that NPY may be released with noradrenaline when sympathetic noradrenergic nerves are activated. Norepinephrine 52-65 neuropeptide Y Homo sapiens 16-19 3755659-7 1986 The increase in NPY correlated with the increase in noradrenaline, suggesting that NPY may be released with noradrenaline when sympathetic noradrenergic nerves are activated. Norepinephrine 52-65 neuropeptide Y Homo sapiens 83-86 3755659-7 1986 The increase in NPY correlated with the increase in noradrenaline, suggesting that NPY may be released with noradrenaline when sympathetic noradrenergic nerves are activated. Norepinephrine 108-121 neuropeptide Y Homo sapiens 16-19 3755659-7 1986 The increase in NPY correlated with the increase in noradrenaline, suggesting that NPY may be released with noradrenaline when sympathetic noradrenergic nerves are activated. Norepinephrine 108-121 neuropeptide Y Homo sapiens 83-86 3007540-0 1986 Norepinephrine decreases EGF binding in primary rat hepatocyte cultures. Norepinephrine 0-14 epidermal growth factor Rattus norvegicus 25-28 3007540-1 1986 Norepinephrine (NE) produced a dose-dependent inhibition of 125I-epidermal growth factor (EGF) binding to adult rat hepatocytes in primary culture. Norepinephrine 0-14 epidermal growth factor Rattus norvegicus 60-88 3007540-1 1986 Norepinephrine (NE) produced a dose-dependent inhibition of 125I-epidermal growth factor (EGF) binding to adult rat hepatocytes in primary culture. Norepinephrine 0-14 epidermal growth factor Rattus norvegicus 90-93 2873241-0 1986 Actions of noradrenaline recorded intracellularly in rat hippocampal CA1 pyramidal neurones, in vitro. Norepinephrine 11-24 carbonic anhydrase 1 Rattus norvegicus 69-72 3517691-3 1986 The sensitivities of these responses to depression by phencyclidine was N-methyl-D-aspartic acid (IC50 0.4 microM) greater than noradrenaline (IC50 3.9 microM) greater than [D-Ala2,MePhe4,Gly-ol5]enkephalin (IC50 8.5 microM) greater than prolongation of the action potential (41% increase by 30 microM). Norepinephrine 128-141 proenkephalin Rattus norvegicus 196-206 3008207-7 1986 As both serotonin and norepinephrine are preferentially metabolized by MAO-A rather than MAO-B, an increased availability of serotonin (the precursor of melatonin) or enhanced noradrenergic function might mediate the melatonin changes observed to follow MAO-A but not MAO-B inhibition. Norepinephrine 22-36 monoamine oxidase A Homo sapiens 71-76 3008207-7 1986 As both serotonin and norepinephrine are preferentially metabolized by MAO-A rather than MAO-B, an increased availability of serotonin (the precursor of melatonin) or enhanced noradrenergic function might mediate the melatonin changes observed to follow MAO-A but not MAO-B inhibition. Norepinephrine 22-36 monoamine oxidase A Homo sapiens 254-259 3010387-9 1986 NPY and PYY potentiated the response to noradrenaline in the artery, as well as the response to histamine in the vein. Norepinephrine 40-53 neuropeptide Y Oryctolagus cuniculus 0-3 3721190-4 1986 Adrenaline and noradrenaline proved to be even more effective in increasing splenic ODC activity than isoproterenol. Norepinephrine 15-28 ornithine decarboxylase 1 Rattus norvegicus 84-87 3096916-3 1986 Fluorescence microscopy of adjacent sections demonstrated that the cells stained for t-PA contained noradrenaline. Norepinephrine 100-113 plasminogen activator, tissue type Rattus norvegicus 85-89 3018392-6 1986 Secondly, NPY has an indirect postjunctional effect in that it potentiates the response to various vasoconstrictors; this was studied on the rabbit femoral artery and vein, using noradrenaline and histamine, respectively, as vasoconstrictors. Norepinephrine 179-192 neuropeptide Y Oryctolagus cuniculus 10-13 3523279-6 1986 Furthermore, E2 enhanced the sensitivity and the responsiveness of LHRH terminals to norepinephrine (NE). Norepinephrine 85-99 gonadotropin releasing hormone 1 Rattus norvegicus 67-71 4079740-1 1985 Many experimental studies have utilized the activity of dopamine-beta-hydroxylase (DBH) as an index of sympathetic activity, since this enzyme is not submitted to uptake mechanisms or to enzymatic metabolism as are the circulating catecholamines norepinephrine (NE) and epinephrine (E). Norepinephrine 246-260 dopamine beta-hydroxylase Homo sapiens 56-81 4079740-1 1985 Many experimental studies have utilized the activity of dopamine-beta-hydroxylase (DBH) as an index of sympathetic activity, since this enzyme is not submitted to uptake mechanisms or to enzymatic metabolism as are the circulating catecholamines norepinephrine (NE) and epinephrine (E). Norepinephrine 246-260 dopamine beta-hydroxylase Homo sapiens 83-86 3840999-2 1985 The plasma levels of neuropeptide Y correlated better with the levels of noradrenaline than adrenaline, suggesting release of a neural origin. Norepinephrine 73-86 neuropeptide Y Homo sapiens 21-35 2418289-0 1985 Competitive inhibition of acetylcholinesterase by bretylium: possible mechanism for its induction of norepinephrine release. Norepinephrine 101-115 acetylcholinesterase Rattus norvegicus 26-46 2418289-4 1985 It is suggested that inhibition of acetylcholinesterase activity by bretylium induces norepinephrine release through the effect of accumulated acetylcholine on nicotinic receptors in adrenergic nerve terminals. Norepinephrine 86-100 acetylcholinesterase Rattus norvegicus 35-55 3914638-5 1985 It was also demonstrated, using correlative light microscopic immunostaining on serial sections and double electron microscopic immunocytochemistry, that C-PON and NPY immunoreactivities are co-localized in neuronal cell bodies of the brain cortex, sympathetic ganglion cells, norepinephrine-containing granules of the adrenal medulla and in human pheochromocytoma tumor cells. Norepinephrine 277-291 neuropeptide Y Homo sapiens 164-167 2864433-2 1985 Spontaneous and evoked release of epinephrine was markedly reduced, when rats were pretreated with 2,3-dichloro-alpha-methylbenzylamine, an inhibitor of phenylethanolamine N-methyltransferase, the enzyme catalyzing the formation of epinephrine from norepinephrine, 80 mg/kg i.p., before decapitation. Norepinephrine 249-263 phenylethanolamine-N-methyltransferase Rattus norvegicus 153-191 2864784-1 1985 The action of neuropeptide Y (NPY), which coexists with noradrenaline (NA) in perivascular sympathetic nerves, has been examined on feline cerebrovascular smooth muscle using a sensitive in vitro system. Norepinephrine 56-69 neuropeptide Y Homo sapiens 14-28 2864784-1 1985 The action of neuropeptide Y (NPY), which coexists with noradrenaline (NA) in perivascular sympathetic nerves, has been examined on feline cerebrovascular smooth muscle using a sensitive in vitro system. Norepinephrine 56-69 neuropeptide Y Homo sapiens 30-33 2993777-0 1985 Dopamine-beta-hydroxylase inhibition acutely stimulates rats hypothalamic noradrenaline and dopamine neuronal activity as assessed from metabolic ratios and circulating glucose and ACTH responses. Norepinephrine 74-87 dopamine beta-hydroxylase Rattus norvegicus 0-25 2993777-1 1985 Because central noradrenaline neuronal activity is tonically inhibited by noradrenaline (NA) itself via an action at prejunctional alpha 2-adrenoceptors, it was hypothesised that the blockade of central NA synthesis following acute dopamine-beta -hydroxylase (DBH) inhibition might primarily deplete prejunctional NA levels and result in an increase in central NA neuronal activity through reduced NA autoinhibition. Norepinephrine 74-87 dopamine beta-hydroxylase Rattus norvegicus 232-258 3896847-0 1985 The effect of insulin and noradrenaline on the uptake of 2-[1-14C]deoxyglucose in vivo by brown adipose tissue and other glucose-utilising tissues of the mouse. Norepinephrine 26-39 WD and tetratricopeptide repeats 1 Mus musculus 96-103 3896847-2 1985 When mice were treated with noradrenaline the rate of uptake of 2-[1-14C]deoxyglucose by brown adipose tissue was increased 6-fold with the only other change occurring in heart where a 5-fold increase was observed. Norepinephrine 28-41 WD and tetratricopeptide repeats 1 Mus musculus 95-102 3896847-4 1985 The amount of 2-[1-14C]deoxyglucose taken up by brown adipose tissue compared to other tissues and the changes in this uptake after administration of noradrenaline or insulin suggest that brown adipose tissue is capable of playing a quantitatively important role in glucose removal from the blood. Norepinephrine 150-163 WD and tetratricopeptide repeats 1 Mus musculus 54-61 3896847-4 1985 The amount of 2-[1-14C]deoxyglucose taken up by brown adipose tissue compared to other tissues and the changes in this uptake after administration of noradrenaline or insulin suggest that brown adipose tissue is capable of playing a quantitatively important role in glucose removal from the blood. Norepinephrine 150-163 WD and tetratricopeptide repeats 1 Mus musculus 194-201 3928874-0 1985 Neuropeptide Y potentiates noradrenaline-evoked vasoconstriction: mode of action. Norepinephrine 27-40 neuropeptide Y Oryctolagus cuniculus 0-14 3928874-1 1985 Neuropeptide Y (NPY), which co-exists with noradrenaline (NA) in postganglionic sympathetic nerves, was able to potentiate NA-evoked constriction in certain isolated rabbit blood vessels. Norepinephrine 43-56 neuropeptide Y Oryctolagus cuniculus 0-14 3928874-1 1985 Neuropeptide Y (NPY), which co-exists with noradrenaline (NA) in postganglionic sympathetic nerves, was able to potentiate NA-evoked constriction in certain isolated rabbit blood vessels. Norepinephrine 43-56 neuropeptide Y Oryctolagus cuniculus 16-19 2861818-2 1985 The influence has been studied of 11 phenothiazine drugs on the oxidation of the catecholamine neurotransmitters noradrenaline and dopamine, catalyzed by human ceruloplasmin. Norepinephrine 113-126 ceruloplasmin Homo sapiens 160-173 2862963-3 1985 Noradrenaline depletion in the cerebral cortex was obtained by peripheral injections of 6-hydroxydopamine (6-OHDA) at birth or N-2-chloroethyl-N-ethyl-2-bromobenzylamine (DSP4) at various postnatal ages and controlled by the absence of dopamine-beta-hydroxylase-labelled axons. Norepinephrine 0-13 dopamine beta-hydroxylase Rattus norvegicus 236-261 3987067-1 1985 Fusaric acid, an inhibitor of dopamine beta-hydroxylase, which converts dopamine to noradrenaline, lowered the blood pressure and induced a subjective improvement in patients with phaeochromocytoma. Norepinephrine 84-97 dopamine beta-hydroxylase Homo sapiens 30-55 3991764-0 1985 Dopamine-beta-hydroxylase inhibitors, feeding and locomotor activity: reinstatement of feeding following central norepinephrine. Norepinephrine 113-127 dopamine beta-hydroxylase Rattus norvegicus 0-25 2988261-1 1985 Noradrenaline (NA) exerts its physiological and pharmacological effects in the central nervous system by interacting with specific receptor sites which are divided into four subtypes, namely alpha-1, alpha-2, beta-1 and beta-2 adrenoceptors. Norepinephrine 0-13 hemoglobin, beta adult major chain Mus musculus 209-215 3973827-8 1985 Significant elevations of arterial plasma norepinephrine, epinephrine and dopamine occurred after T-2, with metabolic acidosis, hypocarbia and hyperoxemia in both conscious rats and guinea pigs. Norepinephrine 42-56 brachyury 2 Rattus norvegicus 98-101 3967057-3 1985 Lipase activity at pH 5.0 is completely inhibited by 0.2 M sodium fluoride and can be stimulated by norepinephrine (10 micrograms/ml). Norepinephrine 100-114 lipase G, endothelial type Rattus norvegicus 0-6 2408793-3 1985 Transplantable norepinephrine-rich tumors, which gave rise to significant blood pressure elevations, contained measurable immunoreactive enkephalins as determined by specific radioimmunoassays for leucine-enkephalin and methionine-enkephalin. Norepinephrine 15-29 proenkephalin Rattus norvegicus 137-147 3905724-1 1985 The aim of the present investigation was to study the distribution in the rat pineal gland of dopamine-beta-hydroxylase (DBH) which is essential for the formation of the melatonin synthesis-regulating substance noradrenaline (NA). Norepinephrine 211-224 dopamine beta-hydroxylase Rattus norvegicus 94-119 3905724-1 1985 The aim of the present investigation was to study the distribution in the rat pineal gland of dopamine-beta-hydroxylase (DBH) which is essential for the formation of the melatonin synthesis-regulating substance noradrenaline (NA). Norepinephrine 211-224 dopamine beta-hydroxylase Rattus norvegicus 121-124 2578061-1 1985 Significant amounts of acid-hydrolyzable conjugates of 3,4-dihydroxyphenylethylamine, norepinephrine, and 5-hydroxytryptamine were detected in lumbar CSF from 22 awake unpremedicated healthy individuals. Norepinephrine 86-100 colony stimulating factor 2 Homo sapiens 150-153 4078568-3 1985 The disappearances of dopamine and noradrenaline after alpha-methyltyrosine and the disappearance of noradrenaline after inhibition of the dopamine-beta-hydroxylase were not changed by decentralization or stimulation. Norepinephrine 101-114 dopamine beta-hydroxylase Rattus norvegicus 139-164 7202481-1 1980 After 7 day dosing with SK & F 64139, an inhibitor of adrenal and CNS PNMT, a stoichiometric relationship is observed between epinephrine decrease and norepinephrine increase in adrenal tissue. Norepinephrine 155-169 phenylethanolamine-N-methyltransferase Rattus norvegicus 74-78 7459080-1 1980 Dopamine-beta-Hydroxylase is the enzyme that catalyzes the conversion of dopamine to norepinephrine. Norepinephrine 85-99 dopamine beta-hydroxylase Homo sapiens 0-25 6244905-3 1980 Helical strips of rat tail artery relax in response to potassium after norepinephrine-induced contractions in physiological salt solution containing a low-potassium concentration. Norepinephrine 71-85 relaxin 1 Rattus norvegicus 34-39 6155770-0 1980 Effects of the histamine H2-receptor agonists dimaprit and 4-methylhistamine on the central noradrenaline and serotonin system. Norepinephrine 92-105 histamine receptor H 2 Rattus norvegicus 15-36 6766787-0 1980 Increased dopamine and norepinephrine concentrations in primate CSF following amphetamine and phenylethylamine administration. Norepinephrine 23-37 colony stimulating factor 2 Homo sapiens 64-67 6101988-3 1980 However, in the C-2-area, the epinephrine and norepinephrine stimulated cyclic AMP formation involved the activation of a single receptor type which was alpha-like in character. Norepinephrine 46-60 complement C2 Rattus norvegicus 16-19 6160707-1 1980 The paper deals with a modulatory function of Substance P (SP) (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2) with bearing on nociperception, behaviour, and norepinephrine uptake. Norepinephrine 159-173 tachykinin 1 Mus musculus 46-57 6160707-1 1980 The paper deals with a modulatory function of Substance P (SP) (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2) with bearing on nociperception, behaviour, and norepinephrine uptake. Norepinephrine 159-173 tachykinin 1 Mus musculus 59-61 6160707-5 1980 SP was found to inhibit or stimulate norepinephrine uptake of hypothalamus preparations depending on the experimental conditions. Norepinephrine 37-51 tachykinin 1 Mus musculus 0-2 6101345-3 1980 Adrenal dopamine-beta-hydroxylase was also inhibited by NLCAs [3"O-methylnorlaudanosolinecarboxylic acid (MNLCA) Kj = 1.2 x 10(-4) M] and NLCA is a competitive inhibitor of norepinephrine methylation by hepatic catechol-O-methyltransferase (NLCA Kj = 5.6 x 10(-5) M). Norepinephrine 173-187 dopamine beta-hydroxylase Rattus norvegicus 8-33 458440-2 1979 The present study represents an effort to evaluate and to place in proper perspective data based on the DbetaH activity found in the region of the light vesicle peak of noradrenaline (NA), which is used as a quantitative measure of a population of small terminal vesicles. Norepinephrine 169-182 dopamine beta-hydroxylase Rattus norvegicus 104-110 367530-1 1979 Dopamine-beta-hydroxylase (DBH), the enzyme that converts dopamine to norepinephrine, has been localized in light and electron microscopic preparations of rat brain by an immunocytochemical method using a peroxidase--anti-peroxidase Fab complex. Norepinephrine 70-84 dopamine beta-hydroxylase Rattus norvegicus 27-30 33344-2 1978 The high Km value for the brain PNMT has been assumed to be responsible for the low methylation ratio between norepinephrine and epinephrine in the CNS. Norepinephrine 110-124 phenylethanolamine-N-methyltransferase Rattus norvegicus 32-36 29697-5 1978 Immunohistochemical localization of antibodies to dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) demonstrated that types of SIF cell localize antibodies to DBH but not PNMT, providing strong evidence that norepinephrine is the neurotransmitter for all the SIF cells of the guinea pig SCG. Norepinephrine 240-254 phenylethanolamine N-methyltransferase Cavia porcellus 126-130 29697-5 1978 Immunohistochemical localization of antibodies to dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) demonstrated that types of SIF cell localize antibodies to DBH but not PNMT, providing strong evidence that norepinephrine is the neurotransmitter for all the SIF cells of the guinea pig SCG. Norepinephrine 240-254 dopamine beta-hydroxylase Cavia porcellus 191-194 730257-0 1978 CSF norepinephrine in cerebrovascular accidents. Norepinephrine 4-18 colony stimulating factor 2 Homo sapiens 0-3 29422-0 1978 Effect of norepinephrine synthesis inhibitors and a dopamine agonist on hypothalamic LH-RH serum gonadotrophin and prolactin levels in gonadal steroid treated rats. Norepinephrine 10-24 gonadotropin releasing hormone 1 Rattus norvegicus 85-90 683787-5 1978 These results are consistent with the hypothesis that biochemically primitive neuroblastomas deficient in dopamine beta-hydroxylase are move virulent than their mature analogues which produce epinephrine, norepinephrine, and their metabolites. Norepinephrine 205-219 dopamine beta-hydroxylase Homo sapiens 106-131 25469-9 1978 These data suggest that cAMP mediates the effect of norepinephrine, which has been shown to diminish the change in pHi accompanying respiratory acidosis. Norepinephrine 52-66 glucose-6-phosphate isomerase Rattus norvegicus 115-118 24033-5 1978 A32390A inhibits dopamine-beta-hydroxylase reduces heart and adrenal norepinephrine levels, lowers blood pressure in hypertensive rats, and possesses antibiotic activity vs. Gram-positive bacteria and fungi, including Candida albicans. Norepinephrine 69-83 dopamine beta-hydroxylase Rattus norvegicus 17-42 201940-0 1977 Possible role of dopamine-beta-hydroxylase in the regulation of norepinephrine biosynthesis in rat brain. Norepinephrine 64-78 dopamine beta-hydroxylase Rattus norvegicus 17-42 201940-1 1977 In Experiment 1, the dose-response effects of three dopamine-beta-hydroxylase (DBH) inhibitors (diethyldithiocarbamate, FLA-63 and U-14, 624) on the endogenous levels of norepinephrine and dopamine in pons-medulla of rat brain were determined. Norepinephrine 170-184 dopamine beta-hydroxylase Rattus norvegicus 52-77 201940-1 1977 In Experiment 1, the dose-response effects of three dopamine-beta-hydroxylase (DBH) inhibitors (diethyldithiocarbamate, FLA-63 and U-14, 624) on the endogenous levels of norepinephrine and dopamine in pons-medulla of rat brain were determined. Norepinephrine 170-184 dopamine beta-hydroxylase Rattus norvegicus 79-82 201940-5 1977 The results from the three experiments are consistent with the idea that DBH is involved in the regulation of norepinephrine biosynthesis. Norepinephrine 110-124 dopamine beta-hydroxylase Rattus norvegicus 73-76 891046-2 1977 Dopamine-beta-hydroxylase (D beta H) activity was measured in sera from ten healthy male students after 2 and 3 days fasting which is associated with increased circulating noradrenaline. Norepinephrine 172-185 dopamine beta-hydroxylase Homo sapiens 0-25 871531-4 1977 Contractions produced by exogenous norepinephrine or serotonin in a potassium-free bath were also made to relax by the addition of potassium. Norepinephrine 35-49 neurogenin 3 Rattus norvegicus 106-111 991816-7 1976 These results suggest that there is a causal relationship between the high levels of progesterone in the uterus and the reduced amount of norepinephrine transmitter in the adrenergic nerves in this organ, and that plasma progesterone concentration and the changing progesterone receptor levels regulate uterine progesterone concentration. Norepinephrine 138-152 progesterone receptor Oryctolagus cuniculus 265-286 1053066-1 1976 Study is presented of the effect of noradrenaline on thermic denaturation of DNA-total histone complexes within the range of protein concentrations which corresponds to c1/c2 0-1.7 in solutions of 10(-3) M Na+ ionic strength (c1 and c2 being the weight concentrations of protein and nucleic acid, respectively). Norepinephrine 36-49 heterogeneous nuclear ribonucleoprotein C Homo sapiens 169-180 782312-3 1976 Dopamine-beta-hydroxylase, the enzyme responsible for conversion of dopamine to norepinephrine, is released along with catecholamines from the adrenal medulla and from sympathetic nerve endings. Norepinephrine 80-94 dopamine beta-hydroxylase Homo sapiens 0-25 782312-12 1976 Inhibition of dopamine-beta-hydroxylase provides a useful pharmacologic approach to evaluating the role of norepinephrine in psychiatric disorders. Norepinephrine 107-121 dopamine beta-hydroxylase Homo sapiens 14-39 954850-0 1976 Enkephalin: a potential modulator of noradrenaline release in rat brain. Norepinephrine 37-50 proenkephalin Rattus norvegicus 0-10 966380-1 1976 Dopamine-beta-hydroxylase (DBH), the enzyme responsible for the biosynthesis of norepinephrine from dopamine was assayed in the blood serum of 23 normal adults, 16 patients with congestive heart failure, 19 patients with asymptomatic ischemic heart disease, 4 patients with angina pectoris at rest, 15 patients with essential hypertension, 8 patients with essential hypotension, 5 patients with neurocirculatory asthenia, and 9 normal adults before and after the exercise test. Norepinephrine 80-94 dopamine beta-hydroxylase Homo sapiens 0-25 966380-1 1976 Dopamine-beta-hydroxylase (DBH), the enzyme responsible for the biosynthesis of norepinephrine from dopamine was assayed in the blood serum of 23 normal adults, 16 patients with congestive heart failure, 19 patients with asymptomatic ischemic heart disease, 4 patients with angina pectoris at rest, 15 patients with essential hypertension, 8 patients with essential hypotension, 5 patients with neurocirculatory asthenia, and 9 normal adults before and after the exercise test. Norepinephrine 80-94 dopamine beta-hydroxylase Homo sapiens 27-30 6786-1 1976 SK&F 64139 is a potent, reversible inhibitor of phenylethanolamine N-methyltransferase; its IC50 concentration in our standard assay system was 1 X 10(-7) M. Kinetically, the compound is a competitive inhibitor with respect to norepinephrine but is uncompetitive when S-adenosylmethionine is the variable substrate. Norepinephrine 231-245 phenylethanolamine-N-methyltransferase Rattus norvegicus 52-90 1244775-2 1976 The dissociation between transmitter release and enzyme release in the presence of cyclopropane may be the result of either an increase in the affinity of norepinephrine for binding sites on the vesicular membrane produced by cyclopropane, or a direct effect of cyclopropane on a mechanism of release of norepinephrine that could be controlled independently of release of dopamine-beta-hydroxylase. Norepinephrine 155-169 dopamine beta-hydroxylase Cavia porcellus 372-397 133361-4 1976 The maintenance of a sufficient level of active norepinephrine on beta-receptors, either by displacement of norepinephrine in the nerve endings by dopamine, or by the inhibition of norepinephrine reuptake by imipramine, thus slows down or prevents the decrease in serotonin N-acetyltransferase activity after exposure to light during the night. Norepinephrine 48-62 aralkylamine N-acetyltransferase Rattus norvegicus 264-293 176694-17 1976 Further, a comparison of adenylate cyclase activities with norepinephrine binding yields a turnover number for the enzyme of the order of 10(-2) sec-1, assuming a 1:1 relationship between beta-adrenergic recptor and adenylate cyclase. Norepinephrine 59-73 secretory blood group 1 Rattus norvegicus 145-150 1064147-0 1976 Effect of epinephrine and norepinephrine on gastrin release and gastric secretion of acid in man. Norepinephrine 26-40 gastrin Homo sapiens 44-51 1064147-3 1976 Norepinephrine in the low dose (n=11) caused a very small increase in gastrin release and no change in acid secretion, whereas the high dose (n=11) inhibited acid secretion without any change in gastrin concentration. Norepinephrine 0-14 gastrin Homo sapiens 70-77 1064147-5 1976 It is concluded that epinephrine and norepinephrine both may be of importance in the physiological regulation of gastrin release and gastric acid secretion. Norepinephrine 37-51 gastrin Homo sapiens 113-120 1237420-2 1975 It has been recently reported that plasma dopamine-beta-hydroxylase (DBH) excreted through the mechanism of the exocytosis with noradrenaline from the sympathetic postganglionic nervous endings is a mirror of the function of the sympathetic nervous system. Norepinephrine 128-141 dopamine beta-hydroxylase Homo sapiens 42-67 1237420-2 1975 It has been recently reported that plasma dopamine-beta-hydroxylase (DBH) excreted through the mechanism of the exocytosis with noradrenaline from the sympathetic postganglionic nervous endings is a mirror of the function of the sympathetic nervous system. Norepinephrine 128-141 dopamine beta-hydroxylase Homo sapiens 69-72 1174970-11 1975 In contrast, and despite the fluorescence findings, the total norepinephrine content of weaver and staggerer cerebella is significantly reduced and concentrations are not significantly different from normal. Norepinephrine 62-76 RAR-related orphan receptor alpha Mus musculus 99-108 1111112-1 1975 Postmorten brain specimens from nine chronic schizophrenic patients and nine control were assayed for activity of dopamine beta-hydroxylase, the enzyme responsible for the conversion of dopamine to norepinephrine. Norepinephrine 198-212 dopamine beta-hydroxylase Homo sapiens 114-139 1150360-1 1975 Dopamine-beta-hydroxylase (DBH) the enzyme responsible for the biosynthesis of noradrenaline from dopamine, was assayed in the blood plasma of 19 cases with hypertension before and during beta-receptor blockade. Norepinephrine 79-92 dopamine beta-hydroxylase Homo sapiens 0-25 1150360-1 1975 Dopamine-beta-hydroxylase (DBH) the enzyme responsible for the biosynthesis of noradrenaline from dopamine, was assayed in the blood plasma of 19 cases with hypertension before and during beta-receptor blockade. Norepinephrine 79-92 dopamine beta-hydroxylase Homo sapiens 27-30 1145901-1 1975 Dopamine-beta-hydroxylase (DBH), the enzyme responsible for the biosynthesis of noradrenalin from dopamine, was assayed in the blood plasma of 20 men with primary hypertension. Norepinephrine 80-92 dopamine beta-hydroxylase Homo sapiens 0-25 1145901-1 1975 Dopamine-beta-hydroxylase (DBH), the enzyme responsible for the biosynthesis of noradrenalin from dopamine, was assayed in the blood plasma of 20 men with primary hypertension. Norepinephrine 80-92 dopamine beta-hydroxylase Homo sapiens 27-30 4155067-8 1974 All treatments appear to activate tyrosine hydroxylase by causing an increase in its affinity for substrate and pteridine cofactor and by decreasing its affinity for the end-product inhibitor, norepinephrine. Norepinephrine 193-207 tyrosine 3-monooxygenase Cavia porcellus 34-54 4155067-9 1974 These results provide direct evidence that the enhanced formation of norepinephrine seen during stimulation of sympathetically innervated tissues arises from an activation of tyrosine hydroxylase. Norepinephrine 69-83 tyrosine 3-monooxygenase Cavia porcellus 175-195 4805003-8 1973 However, addition of reduced ascorbic acid, the cosubstrate for dopamine beta-hydroxylase, markedly stimulated the conversion of dopamine (DA) to norepinephrine (NE). Norepinephrine 146-160 dopamine beta-hydroxylase Homo sapiens 64-89 4365377-1 1973 Depletion of neural norepinephrine by reserpine treatment or by denervation resulted in a greater induction of serotonin N-acetyltransferase (EC 2.3.1.5) and a higher elevation of cyclic AMP in postsynaptic pineal cell to small amount of isoproterenol. Norepinephrine 20-34 aralkylamine N-acetyltransferase Rattus norvegicus 111-140 4930475-0 1971 Fusaric (5-butylpicolinic) acid, an inhibitor of dopamine beta-hydroxylase, affects serotonin and noradrenaline. Norepinephrine 98-111 dopamine beta-hydroxylase Homo sapiens 49-74 5121935-0 1971 [Action of catechol-O-methyltransferase on norepinephrine effects in rats adaptated to various temperatures]. Norepinephrine 43-57 catechol-O-methyltransferase Rattus norvegicus 11-39 5472868-0 1970 Studies on central and peripheral noradrenaline neurons using a new dopamine-(beta)-hydroxylase inhibitor. Norepinephrine 34-47 dopamine beta-hydroxylase Homo sapiens 68-95 4913714-0 1970 Release of dopamine-beta-hydroxylase with norepinephrine during cat splenic nerve stimulation. Norepinephrine 42-56 dopamine beta-hydroxylase Homo sapiens 11-36 4390677-17 1969 The evidence indicates that the release of noradrenaline by DCS 30-40 mug/kg per min from nerve terminals supplying the juxtaglomerular apparatus may have caused the enhancement of renin secretion. Norepinephrine 43-56 renin Felis catus 181-186 5351985-0 1969 On the significance of central noradrenaline for motor activity: experiments with a new dopamine beta-hydroxylase inhibitor. Norepinephrine 31-44 dopamine beta-hydroxylase Homo sapiens 88-113 5762612-2 1969 Both drugs inhibit dopamine-beta-hydroxylase, the enzyme responsible for the final step in the biosynthesis of norepinephrine. Norepinephrine 111-125 dopamine beta-hydroxylase Rattus norvegicus 19-44 6026255-0 1967 Quantitative aspects of the replacement of norepinephrine by dopamine as a sympathetic transmitter after inhibition of dopamine-beta-hydroxylase by disulfiram. Norepinephrine 43-57 dopamine beta-hydroxylase Homo sapiens 119-144 33904806-1 2021 OBJECTIVE: To determine the in vitro effects of epinephrine, norepinephrine, and dobutamine on lipopolysaccharide (LPS)-stimulated production of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-10 (IL-10) in blood from healthy dogs. Norepinephrine 61-75 tumor necrosis factor Canis lupus familiaris 145-172 33093660-0 2021 Binding pathway determines norepinephrine selectivity for the human beta1AR over beta2AR. Norepinephrine 27-41 adenosine A2a receptor Homo sapiens 81-88 33995135-1 2021 Dopamine-beta-hydroxylase (DbetaH) is an enzyme converting dopamine to norepinephrine, a key neurotransmitter in mood disorders, such as major depressive disorder (MDD) and bipolar disorder (BD). Norepinephrine 71-85 dopamine beta-hydroxylase Homo sapiens 0-25 33895869-5 2021 The exclusion of norepinephrine (NE) from synaptic vesicles leads to its oxidation into the toxic metabolite 3,4-dihydroxyphenyl glycolaldehyde (DOPEGAL), which subsequently activates cleavage of Tau at N368 by asparagine endopeptidase (AEP) and triggers LC neurodegeneration. Norepinephrine 17-31 microtubule associated protein tau Homo sapiens 196-199 33722543-8 2021 Consistent with previous in vivo observations in mice, ErbB4 deficiency led to increases in extracellular dopamine and norepinephrine levels. Norepinephrine 119-133 erb-b2 receptor tyrosine kinase 4 Mus musculus 55-60 33845730-3 2022 Such persistent HSC activation could be mediated by norepinephrine (NE), a reaction product of dopamine beta-hydroxylase (DBH). Norepinephrine 52-66 dopamine beta-hydroxylase Homo sapiens 95-120 33845730-3 2022 Such persistent HSC activation could be mediated by norepinephrine (NE), a reaction product of dopamine beta-hydroxylase (DBH). Norepinephrine 52-66 dopamine beta-hydroxylase Homo sapiens 122-125 33855088-4 2021 Results: The norepinephrine levels were markedly high in gastric cancer tissue, while the norepinephrine-degrading enzymes MAOA and MAOB showed low expression. Norepinephrine 90-104 monoamine oxidase A Homo sapiens 123-127 33855088-8 2021 The norepinephrine-degrading enzymes MAOA and MAOB have significant expression differences in cancer and normal tissue, and their missing or low expression may predict immune therapy outcomes for gastric cancer patients. Norepinephrine 4-18 monoamine oxidase A Homo sapiens 37-41 33388353-4 2021 These results suggest that neonatal overfeeding in female rats promotes reproductive dysfunctions in adulthood, such as lower estradiol plasma levels associated with impairments in fertility and noradrenaline-kisspeptin-GnRH pathway during positive feedback. Norepinephrine 195-208 gonadotropin releasing hormone 1 Rattus norvegicus 220-224 33746717-7 2021 Immunolabeling for dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT), enzymes responsible for the synthesis of norepinephrine (NE) and epinephrine (E), respectively, were evaluated. Norepinephrine 143-157 dopamine beta-hydroxylase Rattus norvegicus 19-44 33746717-7 2021 Immunolabeling for dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT), enzymes responsible for the synthesis of norepinephrine (NE) and epinephrine (E), respectively, were evaluated. Norepinephrine 143-157 dopamine beta-hydroxylase Rattus norvegicus 46-49 33746717-7 2021 Immunolabeling for dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT), enzymes responsible for the synthesis of norepinephrine (NE) and epinephrine (E), respectively, were evaluated. Norepinephrine 143-157 phenylethanolamine-N-methyltransferase Rattus norvegicus 95-99 33481407-16 2021 CONCLUSIONS: Our findings demonstrate that treatment with epinephrine or norepinephrine strongly reduces endothelial permeability induced by agonists of multiple Toll-like receptors (Toll-like receptor-2, Toll-like receptor-3, Toll-like receptor-4) in vitro. Norepinephrine 73-87 toll like receptor 4 Homo sapiens 227-247 33434145-7 2021 Exposure of excess norepinephrine significantly restricted the induced expression of decidualized markers Dtprp, BMP2, WNT4, and Hand2 in mice. Norepinephrine 19-33 heart and neural crest derivatives expressed 2 Mus musculus 129-134 33434145-10 2021 The alpha1b-adrenergic receptor expression was upregulated by norepinephrine. Norepinephrine 62-76 adrenergic receptor, alpha 1b Mus musculus 4-31 33434145-11 2021 Interestingly, norepinephrine did not inhibit the expression of IGFBP1 in endometrial stromal cells after silencing alpha1b-adrenergic receptor, while significantly suppressed the induced decidualization with overexpression of alpha1b-adrenergic receptor. Norepinephrine 15-29 adrenergic receptor, alpha 1b Mus musculus 227-254 33434145-12 2021 When alpha1b-adrenergic receptor was activated, endometrial p-PKC was significantly increased under post-treatment with norepinephrine in vivo and in vitro. Norepinephrine 120-134 adrenergic receptor, alpha 1b Mus musculus 5-32 33434145-14 2021 Therefore, norepinephrine exposure inhibited endometrial decidualization through the activation of the PKC signaling pathway by upregulating alpha1b-adrenergic receptor. Norepinephrine 11-25 adrenergic receptor, alpha 1b Mus musculus 141-168 33484195-0 2021 Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation. Norepinephrine 0-14 adrenergic receptor, beta 2 Mus musculus 64-89 32954502-4 2021 These observations suggest that noradrenaline protects neurons from oxidative stress-induced death by increasing the supply of GSH from astrocytes to neurons via the stimulation of beta3 -adrenoceptor in astrocytes. Norepinephrine 32-45 adrenoceptor beta 3 Homo sapiens 181-200 32954502-7 2021 The neuroprotective effect of noradrenaline was inhibited by SR59230A, a selective beta3 -adrenoceptor antagonist, and CL316243, a selective beta3 -adrenoceptor agonist, mimicked the neuroprotective effect of noradrenaline. Norepinephrine 30-43 adrenoceptor beta 3 Homo sapiens 83-102 33352230-9 2021 Knockdown of Piezo2 in NG also attenuated the baroreflex and increased serum norepinephrine (NE) concentration in WKY rats. Norepinephrine 77-91 piezo-type mechanosensitive ion channel component 2 Rattus norvegicus 13-19 33183171-1 2021 RATIONALE: beta1-adrenoceptors (beta1ARs) exist at intracellular membranes and Organic Cation Transporter 3 (OCT3) mediates norepinephrine entry into cardiomyocytes. Norepinephrine 124-138 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 79-107 33183171-1 2021 RATIONALE: beta1-adrenoceptors (beta1ARs) exist at intracellular membranes and Organic Cation Transporter 3 (OCT3) mediates norepinephrine entry into cardiomyocytes. Norepinephrine 124-138 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 109-113 33183171-7 2021 The same was true at the PM for membrane-impermeant norepinephrine, but the SR response to norepinephrine was suppressed in OCT3KO myocytes. Norepinephrine 91-105 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 124-130 33183171-9 2021 Similarly, OCT3KO selectively suppressed calcium transients and contraction responses to norepinephrine, but not isoproterenol. Norepinephrine 89-103 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 11-17 33183171-11 2021 Moreover, pretreatment with sotatol in OCT3KO myocytes prevented norepinephrine induced PKA activation at both PM and the SR and contractility. Norepinephrine 65-79 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 39-45 33476175-4 2020 The aim of the present study was to experimentally examine the anti-nociceptive effects of tapentadol, an opioid agonist and a norepinephrine reuptake inhibitor (MOR/NRI), in our animal model of orofacial pain. Norepinephrine 127-141 opioid receptor mu 1 Homo sapiens 162-165 33171955-3 2020 )), a selective inhibitor of phenylethanolamine N-methyltransferase (PNMT) that converts noradrenaline (NA) into adrenaline (A), fully reverted mechanical allodynia in the injured hind paw without affecting mechanical sensitivity in the contralateral paw. Norepinephrine 89-102 phenylethanolamine-N-methyltransferase Rattus norvegicus 29-67 33171955-3 2020 )), a selective inhibitor of phenylethanolamine N-methyltransferase (PNMT) that converts noradrenaline (NA) into adrenaline (A), fully reverted mechanical allodynia in the injured hind paw without affecting mechanical sensitivity in the contralateral paw. Norepinephrine 89-102 phenylethanolamine-N-methyltransferase Rattus norvegicus 69-73 32607551-0 2020 Noradrenaline Release from Locus Coeruleus Terminals in the Hippocampus Enhances Excitation-Spike Coupling in CA1 Pyramidal Neurons Via beta-Adrenoceptors. Norepinephrine 0-13 carbonic anhydrase 1 Mus musculus 110-113 32607551-2 2020 Noradrenaline is therefore expected to enhance hippocampal responses to synaptic input; however, noradrenergic agonists have been found to have mixed and sometimes contradictory effects on Schaffer collateral synapses and the resulting CA1 output. Norepinephrine 0-13 carbonic anhydrase 1 Mus musculus 236-239 32607551-3 2020 Here, we examine the effects of endogenous, optogenetically driven noradrenaline release on synaptic transmission and spike output in mouse hippocampal CA1 pyramidal neurons. Norepinephrine 67-80 carbonic anhydrase 1 Mus musculus 152-155 32607551-4 2020 We show that endogenous noradrenaline release enhances the probability of CA1 pyramidal neuron spiking without altering feedforward excitatory or inhibitory synaptic inputs in the Schaffer collateral pathway. Norepinephrine 24-37 carbonic anhydrase 1 Mus musculus 74-77 32896003-2 2020 Dopamine beta-hydroxylase (DbetaH) plays a key role in the conversion of dopamine to norepinephrine, which is related to suicidal behavior and cognitive regulation. Norepinephrine 85-99 dopamine beta-hydroxylase Homo sapiens 0-25 32697958-4 2020 In vitro studies show that OCTs/PMAT are also capable of norepinephrine transport, raising the possibility that decynium-22 might enhance the antidepressant-like effects of norepinephrine transporter inhibitors. Norepinephrine 57-71 solute carrier family 29 member 4 Homo sapiens 32-36 32697958-4 2020 In vitro studies show that OCTs/PMAT are also capable of norepinephrine transport, raising the possibility that decynium-22 might enhance the antidepressant-like effects of norepinephrine transporter inhibitors. Norepinephrine 173-187 solute carrier family 29 member 4 Homo sapiens 32-36 31943210-6 2020 An in-vivo microdialysis study in EFhd2 knock out (KO) mice revealed that EFhd2 controls METH- and cocaine-induced changes in extracellular dopamine (DA), serotonin and noradrenaline levels through different mechanisms in the nucleus accumbens (NAc) and prefrontal cortex (PFC). Norepinephrine 169-182 EF hand domain containing 2 Mus musculus 74-79 32246947-10 2020 When knockdown or overexpression of CerK was performed, Ca2+-induced release of [3H] noradrenaline was reduced or enhanced, respectively, but neurite extension was not modified. Norepinephrine 85-98 ceramide kinase Rattus norvegicus 36-40 32246947-11 2020 There was a positive correlation between noradrenaline release and formation of C1P and/or CerK-HA levels in NGF- and clasto-lactacystin-treated cells. Norepinephrine 41-54 ceramide kinase Rattus norvegicus 91-95 32253104-1 2020 Endogenous noradrenaline (NA) has multiple bioactive functions and, in the central nervous system (CNS), has been implicated in modulating neuroinflammation via beta-adrenergic receptors (beta-ARs). Norepinephrine 11-24 alanyl-tRNA synthetase Mus musculus 188-196 32244188-16 2020 Injections of norepinephrine into the ArcPomc-/- female mice reduced circulating adiponectin levels, whereas injections of propranolol significantly increased adiponectin levels. Norepinephrine 14-28 adiponectin, C1Q and collagen domain containing Mus musculus 81-92 32332538-8 2020 RESULTS: Grafts treated by extracellular vesicles derived from adipose-derived stem cells showed enhanced beige adipose regeneration with increased neovascularization, M2 macrophage proportion, and norepinephrine secretion at postgraft week 4. Norepinephrine 198-212 WD and tetratricopeptide repeats 1 Mus musculus 63-70 32303180-0 2020 Comparison of two Norepinephrine rescue bolus for Management of Post-spinal Hypotension during Cesarean Delivery: a randomized controlled trial. Norepinephrine 18-32 solute carrier family 35 member G1 Homo sapiens 64-68 32188130-6 2020 We compared in vitro the efficacy of clonidine, dexmedetomidine, brimonidine, and norepinephrine with epinephrine to restore ADP- and PAR-1-AP-induced washed platelet aggregation inhibited by ticagrelor, as well as resulting platelet cAMP levels. Norepinephrine 82-96 Prader Willi/Angelman region RNA 1 Homo sapiens 134-139 32188130-8 2020 Compared with epinephrine, norepinephrine, and brimonidine partially restored ADP- and fully restored PAR-1-AP-induced aggregation inhibited by ticagrelor while clonidine and dexmedetomidine were ineffective. Norepinephrine 27-41 Prader Willi/Angelman region RNA 1 Homo sapiens 102-107 31822578-0 2020 Congenital absence of norepinephrine due to CYB561 mutations. Norepinephrine 22-36 cytochrome b561 Homo sapiens 44-50 31822578-1 2020 OBJECTIVE: Cytochrome b561 (CYB561) generates ascorbic acid, a cofactor in the enzymatic conversion of dopamine to norepinephrine by dopamine beta-hydroxylase. Norepinephrine 115-129 cytochrome b561 Homo sapiens 11-26 31822578-1 2020 OBJECTIVE: Cytochrome b561 (CYB561) generates ascorbic acid, a cofactor in the enzymatic conversion of dopamine to norepinephrine by dopamine beta-hydroxylase. Norepinephrine 115-129 cytochrome b561 Homo sapiens 28-34 31822578-1 2020 OBJECTIVE: Cytochrome b561 (CYB561) generates ascorbic acid, a cofactor in the enzymatic conversion of dopamine to norepinephrine by dopamine beta-hydroxylase. Norepinephrine 115-129 dopamine beta-hydroxylase Homo sapiens 133-158 31940997-7 2020 Matured hop bitter acids (MHBAs), oxidized components with beta-carbonyl moieties derived from aged hops, also enhance memory functions via norepinephrine neurotransmission-mediated mechanisms. Norepinephrine 140-154 HOP homeobox Homo sapiens 8-11 31468359-2 2020 In nasal mucosa, high concentrations of NPY are stored with noradrenaline in sympathetic nerve fibers. Norepinephrine 60-73 neuropeptide Y Homo sapiens 40-43 32342809-3 2020 MAO-A is a flavoenzyme, which binds to the outer mitochondrial membrane and catalyzes the oxidative transformations of neurotransmitters like serotonin, norepinephrine, and dopamine. Norepinephrine 153-167 monoamine oxidase A Homo sapiens 0-5 31613389-1 2020 Dopamine beta-hydroxylase (DbetaH) is an essential neurotransmitter-synthesizing enzyme that catalyzes the formation of norepinephrine (NE) from dopamine and has been extensively studied since its discovery in the 1950s. Norepinephrine 120-134 dopamine beta-hydroxylase Homo sapiens 0-25 31875545-3 2019 Norepinephrine activates alpha1 adrenoreceptors in hypothalamic corticotropin-releasing hormone (CRH) neurons to stimulate dendritic release, which triggers an astrocytic calcium response and release of ATP; ATP stimulates action potentials in upstream glutamate and GABA neurons to activate recurrent excitatory and inhibitory synaptic circuits to the CRH neurons. Norepinephrine 0-14 corticotropin releasing hormone Homo sapiens 64-95 31875545-3 2019 Norepinephrine activates alpha1 adrenoreceptors in hypothalamic corticotropin-releasing hormone (CRH) neurons to stimulate dendritic release, which triggers an astrocytic calcium response and release of ATP; ATP stimulates action potentials in upstream glutamate and GABA neurons to activate recurrent excitatory and inhibitory synaptic circuits to the CRH neurons. Norepinephrine 0-14 corticotropin releasing hormone Homo sapiens 97-100 31875545-3 2019 Norepinephrine activates alpha1 adrenoreceptors in hypothalamic corticotropin-releasing hormone (CRH) neurons to stimulate dendritic release, which triggers an astrocytic calcium response and release of ATP; ATP stimulates action potentials in upstream glutamate and GABA neurons to activate recurrent excitatory and inhibitory synaptic circuits to the CRH neurons. Norepinephrine 0-14 corticotropin releasing hormone Homo sapiens 353-356 31875545-4 2019 Thus, norepinephrine activates a retrograde signaling mechanism in CRH neurons that engages astrocytes in order to extend dendritic volume transmission to reach distal presynaptic glutamate and GABA neurons, thereby amplifying volume transmission mediated by dendritic release. Norepinephrine 6-20 corticotropin releasing hormone Homo sapiens 67-70 32186162-10 2019 Finally, we find that kidney invigoration method can change the concentrations of central neurotransmitters of norepinephrine and glutamate to regulate neuro-osteogenic network, and promote the recovery of ovarian function and have an estrogen-like effect by regulating the hypothalamus-pituitary-ovarian axis, which thus influences bone metabolism without clinically significant estrogen-like side effects, and regulate NPY, CGRP and SP involved in the bone metabolism. Norepinephrine 111-125 neuropeptide Y Homo sapiens 421-424 31831958-2 2019 Molecular dynamics simulation (MDS) and docking analysis of biogenic monoamines with ceruloplasmin explain the role of Asp1025, Glu935, Glu272, Glu232 and Glu230 together with the binding site water molecules (referred as conserved water molecules) in the stabilization of neurotransmitter (Serotonin, Norepinephrine and Epinephrine) molecules within the binding cavity of hCP. Norepinephrine 302-316 ceruloplasmin Homo sapiens 85-98 31631645-1 2019 The aim of present work is to assess the effects of bradykinin (Br) or noradrenaline (Nor) preconditioning to the levels of antioxidant enzymes: superoxide dismutase (SOD), copper, zinc superoxide dismutase (CuZn-SOD), manganese superoxide dismutase (Mn-SOD) and catalase in ischemia/reperfusion (I/R) model in the rabbit spinal cord white matter as well as effect on glial fibrillary acidic protein (GFAP) and ubiquitin immunoreaction in glial cells. Norepinephrine 71-84 SOD-2 Oryctolagus cuniculus 219-249 31631645-1 2019 The aim of present work is to assess the effects of bradykinin (Br) or noradrenaline (Nor) preconditioning to the levels of antioxidant enzymes: superoxide dismutase (SOD), copper, zinc superoxide dismutase (CuZn-SOD), manganese superoxide dismutase (Mn-SOD) and catalase in ischemia/reperfusion (I/R) model in the rabbit spinal cord white matter as well as effect on glial fibrillary acidic protein (GFAP) and ubiquitin immunoreaction in glial cells. Norepinephrine 71-84 SOD-2 Oryctolagus cuniculus 251-257 31631645-1 2019 The aim of present work is to assess the effects of bradykinin (Br) or noradrenaline (Nor) preconditioning to the levels of antioxidant enzymes: superoxide dismutase (SOD), copper, zinc superoxide dismutase (CuZn-SOD), manganese superoxide dismutase (Mn-SOD) and catalase in ischemia/reperfusion (I/R) model in the rabbit spinal cord white matter as well as effect on glial fibrillary acidic protein (GFAP) and ubiquitin immunoreaction in glial cells. Norepinephrine 86-89 SOD-2 Oryctolagus cuniculus 219-249 31631645-1 2019 The aim of present work is to assess the effects of bradykinin (Br) or noradrenaline (Nor) preconditioning to the levels of antioxidant enzymes: superoxide dismutase (SOD), copper, zinc superoxide dismutase (CuZn-SOD), manganese superoxide dismutase (Mn-SOD) and catalase in ischemia/reperfusion (I/R) model in the rabbit spinal cord white matter as well as effect on glial fibrillary acidic protein (GFAP) and ubiquitin immunoreaction in glial cells. Norepinephrine 86-89 SOD-2 Oryctolagus cuniculus 251-257 31339804-4 2019 In contrast, hypothalamic-specific ablation of Fgf13 recapitulated weight gain at 30 C. Norepinephrine turnover in brown fat was reduced at both housing temperatures. Norepinephrine 88-102 fibroblast growth factor 13 Mus musculus 47-52 31603552-12 2019 The low levels of ARG, homoarginine, and citrulline may be the consequence of high circulating levels of alpha1 -agonists, such as epinephrine and norepinephrine, and their biochemical interaction with endothelial trace amine-associated receptor 1 that induces activation of NO synthase, resulting in NO synthesis in the circulation, NO release, intense vasodilation, and as a result, the cluster attack. Norepinephrine 147-161 ABL proto-oncogene 2, non-receptor tyrosine kinase Homo sapiens 18-21 31411815-8 2019 Norepinephrine and cyclic adenosine monophosphate induced GDF15 expression and release by cells through protein kinase A-mediated mechanisms. Norepinephrine 0-14 growth differentiation factor 15 Mus musculus 58-63 31279527-7 2019 The down-regulation of NT5DC2 by siRNA increased the synthesis of catecholamines (dopamine, noradrenaline, and adrenaline) in PC12D cells. Norepinephrine 92-105 5'-nucleotidase domain containing 2 Rattus norvegicus 23-29 31484392-6 2019 In contrast, facilitation of spontaneous IPSCs (sIPSCs) by norepinephrine (NE) was significantly reduced in BDNF+/- mice. Norepinephrine 59-73 brain derived neurotrophic factor Mus musculus 108-112 30456877-1 2019 The monoamine oxidase A (MAOA) enzyme metabolizes monoamine neurotransmitters such as dopamine, serotonin and norepinephrine, and its genetic polymorphism (rs1137070) influences its activity level and is associated with smoking behaviors. Norepinephrine 110-124 monoamine oxidase A Homo sapiens 4-23 30456877-1 2019 The monoamine oxidase A (MAOA) enzyme metabolizes monoamine neurotransmitters such as dopamine, serotonin and norepinephrine, and its genetic polymorphism (rs1137070) influences its activity level and is associated with smoking behaviors. Norepinephrine 110-124 monoamine oxidase A Homo sapiens 25-29 30894696-7 2019 Urinary L-DOPA and noradrenaline levels were significantly increased in sik1-/- mice fed a high-salt diet as compared with sik1-/- mice on a control diet. Norepinephrine 19-32 salt inducible kinase 1 Mus musculus 72-76 30894696-8 2019 Similarly, the activity of dopamine beta-hydroxylase (DbetaH), the enzyme that converts dopamine to noradrenaline, was significantly increased in the adrenal glands of sik1-/- mice on a high-salt intake compared with sik1+/+ and sik1-/- mice on a control diet. Norepinephrine 100-113 salt inducible kinase 1 Mus musculus 168-172 31144035-7 2019 We found reduced secretagogin expression in locus coeruleus from subjects with Alzheimer"s disease, and this reduction paralleled the loss of tyrosine hydroxylase, the enzyme rate limiting noradrenaline synthesis. Norepinephrine 189-202 secretagogin, EF-hand calcium binding protein Homo sapiens 17-29 31528826-0 2019 Dipeptidyl Peptidase 4 Inhibition Increases Postprandial Norepinephrine via Substance P (NK1 Receptor) During RAAS Inhibition. Norepinephrine 57-71 dipeptidyl peptidase 4 Homo sapiens 0-22 31528826-0 2019 Dipeptidyl Peptidase 4 Inhibition Increases Postprandial Norepinephrine via Substance P (NK1 Receptor) During RAAS Inhibition. Norepinephrine 57-71 tachykinin receptor 1 Homo sapiens 89-101 31528826-12 2019 During treatment with an ACE inhibitor or angiotensin receptor blocker, DPP4 inhibition increased postprandial norepinephrine through a substance P receptor-dependent mechanism. Norepinephrine 111-125 dipeptidyl peptidase 4 Homo sapiens 72-76 31528826-12 2019 During treatment with an ACE inhibitor or angiotensin receptor blocker, DPP4 inhibition increased postprandial norepinephrine through a substance P receptor-dependent mechanism. Norepinephrine 111-125 tachykinin receptor 1 Homo sapiens 136-156 31242414-7 2019 Moreover, the sympathetic neurotransmitter norepinephrine could inhibit the LPS-elicited innate immunity cell-intrinsically via beta2-adrenergic receptor signaling. Norepinephrine 43-57 adrenergic receptor, beta 2 Mus musculus 128-153 31048375-8 2019 Treatment of brown adipocytes with MetAP2 inhibitors enhances norepinephrine-induced lipolysis and energy expenditure, and prolongs the activity of norepinephrine to increase ucp1 gene expression and energy expenditure in norepinephrine-desensitized brown adipocytes. Norepinephrine 62-76 methionine aminopeptidase 2 Mus musculus 35-41 31048375-8 2019 Treatment of brown adipocytes with MetAP2 inhibitors enhances norepinephrine-induced lipolysis and energy expenditure, and prolongs the activity of norepinephrine to increase ucp1 gene expression and energy expenditure in norepinephrine-desensitized brown adipocytes. Norepinephrine 148-162 methionine aminopeptidase 2 Mus musculus 35-41 31048375-8 2019 Treatment of brown adipocytes with MetAP2 inhibitors enhances norepinephrine-induced lipolysis and energy expenditure, and prolongs the activity of norepinephrine to increase ucp1 gene expression and energy expenditure in norepinephrine-desensitized brown adipocytes. Norepinephrine 148-162 methionine aminopeptidase 2 Mus musculus 35-41 31190968-3 2019 Tapentadol, a centrally acting analgesic, is the first agent of a new class of drugs (MOR-NRI), since it combines two mechanisms of action, namely micro-opioid receptor (MOR) agonism and noradrenaline reuptake inhibition. Norepinephrine 187-200 opioid receptor mu 1 Homo sapiens 86-89 30856610-4 2019 This results in the release of norepinephrine onto adipose tissue inducing a drop of leptin. Norepinephrine 31-45 leptin Homo sapiens 85-91 30759876-4 2019 This uncoupling protein 1 (UCP1)-mediated process requires input from sympathetic nerves releasing norepinephrine. Norepinephrine 99-113 uncoupling protein 1 Homo sapiens 5-25 30759876-4 2019 This uncoupling protein 1 (UCP1)-mediated process requires input from sympathetic nerves releasing norepinephrine. Norepinephrine 99-113 uncoupling protein 1 Homo sapiens 27-31 31304429-4 2019 The biogenic aldehydes produced from dopamine, norepinephrine and serotonin are known to be toxic, generate reactive oxygen species and/or cause aggregation of proteins such as alpha-synuclein. Norepinephrine 47-61 synuclein alpha Homo sapiens 177-192 29341465-7 2019 Moreover, loss of P2Y12 decreased the level of noradrenaline and the expression of noradrenergic alpha receptors, subtypes alpha2 (ARalpha2b) in mouse cerebellum and hippocampus. Norepinephrine 47-60 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 18-23 30510101-3 2019 In the study described here, the noradrenergic system was found to be suppressed with decreased levels of norepinephrine (NE) in brains of infected animals and in infected human and rat neural cells in vitro The mechanism responsible for the NE suppression was found to be downregulation of dopamine beta-hydroxylase (DBH) gene expression, encoding the enzyme that synthesizes norepinephrine from dopamine, with downregulation observed in vitro and in infected brain tissue, particularly in the dorsal locus coeruleus/pons region. Norepinephrine 106-120 dopamine beta-hydroxylase Rattus norvegicus 291-316 30510101-3 2019 In the study described here, the noradrenergic system was found to be suppressed with decreased levels of norepinephrine (NE) in brains of infected animals and in infected human and rat neural cells in vitro The mechanism responsible for the NE suppression was found to be downregulation of dopamine beta-hydroxylase (DBH) gene expression, encoding the enzyme that synthesizes norepinephrine from dopamine, with downregulation observed in vitro and in infected brain tissue, particularly in the dorsal locus coeruleus/pons region. Norepinephrine 106-120 dopamine beta-hydroxylase Rattus norvegicus 318-321 30429409-0 2019 Eukaryotic elongation factor 2 kinase inhibitor, A484954 inhibits noradrenaline-induced acute increase of blood pressure in rats. Norepinephrine 66-79 eukaryotic elongation factor-2 kinase Rattus norvegicus 0-37 30419287-1 2019 The human alpha1D-adrenergic receptor is a seven transmembrane-domain protein that mediates many of the physiological actions of adrenaline and noradrenaline and participates in the development of hypertension and benign prostatic hyperplasia. Norepinephrine 144-157 adrenoceptor alpha 1D Homo sapiens 10-37 31307617-2 2019 The pathology underlying this condition is thought to involve the deposition of alpha synuclein in the autonomic ganglia leading to diminished norepinephrine release and progressive autonomic dysfunction. Norepinephrine 143-157 synuclein alpha Homo sapiens 80-95 30209240-5 2018 Both CNTF and secretagogin ablation occlude stress-induced cortical norepinephrine synthesis, ensuing neuronal excitation and behavioral stereotypes. Norepinephrine 68-82 secretagogin, EF-hand calcium binding protein Homo sapiens 14-26 30192450-3 2018 The antidepressant duloxetine, acting as a serotonin-norepinephrine reuptake inhibitor, is mainly metabolized via CYP1A2. Norepinephrine 53-67 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 114-120 29751052-1 2018 This meta-analytical review examines whether a deletion variant in ADRA2B, a gene that encodes alpha2B adrenoceptor in the regulation of norepinephrine availability, influences cognitive processing of emotional information in human observers. Norepinephrine 137-151 adrenoceptor alpha 2B Homo sapiens 67-73 29935188-5 2018 Norepinephrine content and concentration were reduced depending on the treatment regimen, with a rank order of deficits of PN7-9 > PN1-3 > GD17-19. Norepinephrine 0-14 serpin family E member 2 Rattus norvegicus 134-139 29962965-10 2018 SBE 13 and cyclapolin 9 inhibited contractions by the alpha1-agonists methoxamine, phenylephrine, and noradrenaline. Norepinephrine 102-115 adrenoceptor alpha 1D Homo sapiens 54-60 29478144-7 2018 The MAOA gene encodes an enzyme which is involved in the catabolism of dopamine, norepinephrine, serotonin, and other monoaminergic neurotransmitters. Norepinephrine 81-95 monoamine oxidase A Homo sapiens 4-8 29424419-11 2018 PNMT and VGluT2 co-occur in some pre-synaptic terminals indicating the potential for co-transmission of glutamate and norepinephrine. Norepinephrine 118-132 phenylethanolamine-N-methyltransferase Rattus norvegicus 0-4 29424419-11 2018 PNMT and VGluT2 co-occur in some pre-synaptic terminals indicating the potential for co-transmission of glutamate and norepinephrine. Norepinephrine 118-132 solute carrier family 17 member 6 Rattus norvegicus 9-15 29186431-2 2018 Monoamine oxidase A is one of the key enzymes mediating the turnover of noradrenaline. Norepinephrine 72-85 monoamine oxidase A Homo sapiens 0-19 29615637-5 2018 BRL44408 increased cardiac norepinephrine (NE) concentration in CLP rats. Norepinephrine 27-41 coactosin-like F-actin binding protein 1 Rattus norvegicus 64-67 29166705-6 2018 The system allowed a limit of detection between 0.625 and 2.5 pg muL-1 for monoamine analytes and their metabolites, including dopamine, 3,4-dihydroxyphenylacetic acid, 3-methoxytyramine, homovanillic acid, norepinephrine, epinephrine, 3-methoxy-4-hydroxyphenylglycol, serotonin and 5-hydroxyindoleacetic acid. Norepinephrine 207-221 mitochondrial ubiquitin ligase activator of NFKB 1 Mus musculus 65-70 28760662-8 2018 Intriguingly, in vivo EtOH exposure (4g/kg IP) enhanced c-FOS colocalization with tyrosine hydroxylase via immunohistochemical methods, indicating that NTS norepinephrine neurons may be activated by acute EtOH exposure. Norepinephrine 156-170 FBJ osteosarcoma oncogene Mus musculus 56-61 29485127-0 2018 Norepinephrine Inhibits Th17 Cells via beta2-Adrenergic Receptor (beta2-AR) Signaling in a Mouse Model of Rheumatoid Arthritis. Norepinephrine 0-14 adrenergic receptor, beta 2 Mus musculus 39-64 29485127-0 2018 Norepinephrine Inhibits Th17 Cells via beta2-Adrenergic Receptor (beta2-AR) Signaling in a Mouse Model of Rheumatoid Arthritis. Norepinephrine 0-14 adrenergic receptor, beta 2 Mus musculus 66-74 28895001-3 2018 Norepinephrine (NE) signaling via alpha1 receptors is primarily excitatory, working either directly on CRH neurons or through presynaptic activation of glutamate release. Norepinephrine 0-14 corticotropin releasing hormone Homo sapiens 103-106 29433734-9 2018 FOXO1 knockout within the PNS results in a reduction of sympathetic tone and decreased levels of brain-derived norepinephrine and lower energy expenditure. Norepinephrine 111-125 forkhead box O1 Mus musculus 0-5 28983964-4 2018 We show that in cortical astrocytes BDNF exon IV and exon VI containing mRNAs are induced by dopamine and norepinephrine via CREB-dependent signaling and that this regulation is mediated by a mechanism that is distinct from activity-dependent CREB-mediated activation of BDNF transcription in neurons. Norepinephrine 106-120 cAMP responsive element binding protein 1 Rattus norvegicus 125-129 28983964-4 2018 We show that in cortical astrocytes BDNF exon IV and exon VI containing mRNAs are induced by dopamine and norepinephrine via CREB-dependent signaling and that this regulation is mediated by a mechanism that is distinct from activity-dependent CREB-mediated activation of BDNF transcription in neurons. Norepinephrine 106-120 cAMP responsive element binding protein 1 Rattus norvegicus 243-247 29267189-2 2017 Besides a variety of reports showing the involvement of norepinephrine and its receptor systems in cognition, amyloid beta (Abeta) metabolism, neuroinflammation, and neurogenesis, little is known about the contribution of the specific receptors to these actions. Norepinephrine 56-70 amyloid beta (A4) precursor protein Mus musculus 124-129 28888989-4 2017 alpha1A-Adrenergic receptor interaction with beta-arrestins (colocalization/coimmunoprecipitation) was induced by noradrenaline and oxymetazoline and, to a lesser extent, by phorbol myristate acetate. Norepinephrine 114-127 adrenoceptor alpha 1D Homo sapiens 0-27 28675448-9 2017 Interestingly, the mPGES-1 inhibitor significantly reduced (30-40%) noradrenaline-induced contractions in both vessels. Norepinephrine 68-81 prostaglandin E synthase Mus musculus 19-26 29046732-2 2017 For example, the beta-3 adrenergic receptor (ADRB3) responds to noradrenaline and mediates lipolysis in adipocytes. Norepinephrine 64-77 adrenoceptor beta 3 Homo sapiens 17-43 29046732-2 2017 For example, the beta-3 adrenergic receptor (ADRB3) responds to noradrenaline and mediates lipolysis in adipocytes. Norepinephrine 64-77 adrenoceptor beta 3 Homo sapiens 45-50 28953873-6 2017 Deletion of NLRP3 in ageing restored catecholamine-induced lipolysis by downregulating growth differentiation factor-3 (GDF3) and monoamine oxidase A (MAOA) that is known to degrade noradrenaline. Norepinephrine 182-195 NLR family, pyrin domain containing 3 Mus musculus 12-17 28979194-0 2017 The Locus Coeruleus-Norepinephrine System Mediates Empathy for Pain through Selective Up-Regulation of P2X3 Receptor in Dorsal Root Ganglia in Rats. Norepinephrine 20-34 purinergic receptor P2X 3 Rattus norvegicus 103-107 28423914-4 2017 Neuropeptide Y is co-localized with noradrenaline in central and sympathetic nervous systems. Norepinephrine 36-49 neuropeptide Y Homo sapiens 0-14 28707163-1 2017 Dopamine-beta-hydroxylase (DBH, EC 1.14.17.1), an oxido-reductase that catalyses the conversion of dopamine to norepinephrine, is largely expressed in sympathetic neurons and adrenal medulla. Norepinephrine 111-125 dopamine beta-hydroxylase Homo sapiens 0-25 28707163-1 2017 Dopamine-beta-hydroxylase (DBH, EC 1.14.17.1), an oxido-reductase that catalyses the conversion of dopamine to norepinephrine, is largely expressed in sympathetic neurons and adrenal medulla. Norepinephrine 111-125 dopamine beta-hydroxylase Homo sapiens 27-30 28392265-2 2017 Cocaine-primed reinstatement can also be attenuated by systemic administration of dopamine beta-hydroxylase (DBH) inhibitors, which prevent norepinephrine (NE) synthesis, or by alpha1-adrenergic receptor (alpha1AR) antagonists, indicating functional modulation by the noradrenergic system. Norepinephrine 140-154 dopamine beta-hydroxylase Rattus norvegicus 82-107 28392265-2 2017 Cocaine-primed reinstatement can also be attenuated by systemic administration of dopamine beta-hydroxylase (DBH) inhibitors, which prevent norepinephrine (NE) synthesis, or by alpha1-adrenergic receptor (alpha1AR) antagonists, indicating functional modulation by the noradrenergic system. Norepinephrine 140-154 dopamine beta-hydroxylase Rattus norvegicus 109-112 27776953-2 2017 Dopamine beta-hydroxylase (DBH) gene associated with dopamine and norepinephrine systems influences cognition. Norepinephrine 66-80 dopamine beta-hydroxylase Homo sapiens 0-25 27776953-2 2017 Dopamine beta-hydroxylase (DBH) gene associated with dopamine and norepinephrine systems influences cognition. Norepinephrine 66-80 dopamine beta-hydroxylase Homo sapiens 27-30 28282374-0 2017 Depletion of cardiac catecholamine stores impairs cardiac norepinephrine re-uptake by downregulation of the norepinephrine transporter. Norepinephrine 58-72 solute carrier family 6 member 2 Rattus norvegicus 108-134 28282374-1 2017 In heart failure (HF), a disturbed cardiac norepinephrine (NE) homeostasis is characterized by depleted cardiac NE stores, impairment of the cardiac NE re-uptake by the neuronal norepinephrine transporter (NET) and enhanced cardiac NE net release. Norepinephrine 43-57 solute carrier family 6 member 2 Rattus norvegicus 178-204 28282374-1 2017 In heart failure (HF), a disturbed cardiac norepinephrine (NE) homeostasis is characterized by depleted cardiac NE stores, impairment of the cardiac NE re-uptake by the neuronal norepinephrine transporter (NET) and enhanced cardiac NE net release. Norepinephrine 43-57 solute carrier family 6 member 2 Rattus norvegicus 206-209 28282374-1 2017 In heart failure (HF), a disturbed cardiac norepinephrine (NE) homeostasis is characterized by depleted cardiac NE stores, impairment of the cardiac NE re-uptake by the neuronal norepinephrine transporter (NET) and enhanced cardiac NE net release. Norepinephrine 43-57 solute carrier family 6 member 2 Rattus norvegicus 235-238 27778639-1 2017 Context: Dopamine beta-hydroxylase (DBH) deficiency is a rare genetic disorder characterized by failure to convert dopamine to norepinephrine. Norepinephrine 127-141 dopamine beta-hydroxylase Homo sapiens 9-34 27778639-1 2017 Context: Dopamine beta-hydroxylase (DBH) deficiency is a rare genetic disorder characterized by failure to convert dopamine to norepinephrine. Norepinephrine 127-141 dopamine beta-hydroxylase Homo sapiens 36-39 27959576-6 2016 We found modestly increased adrenal expression of Dbh in transgenic rats versus SHR non-transgenic controls that was associated with reduced adrenal levels of dopamine and increased plasma levels of norepinephrine and epinephrine. Norepinephrine 199-213 dopamine beta-hydroxylase Rattus norvegicus 50-53 26667034-1 2016 The dopamine beta-hydroxylase (DbetaH) enzyme transforms dopamine into noradrenaline. Norepinephrine 71-84 dopamine beta-hydroxylase Homo sapiens 4-29 27979701-0 2016 GPR40/FFAR1 deficient mice increase noradrenaline levels in the brain and exhibit abnormal behavior. Norepinephrine 36-49 free fatty acid receptor 1 Mus musculus 0-5 27979701-0 2016 GPR40/FFAR1 deficient mice increase noradrenaline levels in the brain and exhibit abnormal behavior. Norepinephrine 36-49 free fatty acid receptor 1 Mus musculus 6-11 27979701-11 2016 Therefore, these results suggest that brain GPR40/FFAR1 is associated with anxiety- and depression-related behavior regulated by the increment of noradrenaline in the brain. Norepinephrine 146-159 free fatty acid receptor 1 Mus musculus 44-49 27979701-11 2016 Therefore, these results suggest that brain GPR40/FFAR1 is associated with anxiety- and depression-related behavior regulated by the increment of noradrenaline in the brain. Norepinephrine 146-159 free fatty acid receptor 1 Mus musculus 50-55 27734680-0 2016 Empirical Valence Bond Simulations of the Hydride-Transfer Step in the Monoamine Oxidase A Catalyzed Metabolism of Noradrenaline. Norepinephrine 115-128 monoamine oxidase A Homo sapiens 71-90 27734680-1 2016 Monoamine oxidases (MAOs) A and B are flavoenzymes responsible for the metabolism of biogenic amines, such as dopamine, serotonin, and noradrenaline (NA), which is why they have been extensively implicated in the etiology and course of various neurodegenerative disorders and, accordingly, used as primary pharmacological targets to treat these debilitating cognitive diseases. Norepinephrine 135-148 monoamine oxidase A Homo sapiens 0-33 27734680-3 2016 In this work, we present atomistic empirical valence bond simulations of the rate-limiting step of the MAO-A-catalyzed NA (norepinephrine) degradation, involving hydride transfer from the substrate alpha-methylene group to the flavin moiety of the flavin adenine dinucleotide prosthetic group, employing the full dimensionality and thermal fluctuations of the hydrated enzyme, with extensive configurational sampling. Norepinephrine 123-137 monoamine oxidase A Homo sapiens 103-108 26227907-1 2016 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the metabolism of several biological amines such as dopamine, norepinephrine, and serotonin, which are important neurochemicals in the pathogenesis of major psychiatric illnesses. Norepinephrine 127-141 monoamine oxidase A Homo sapiens 0-19 26227907-1 2016 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the metabolism of several biological amines such as dopamine, norepinephrine, and serotonin, which are important neurochemicals in the pathogenesis of major psychiatric illnesses. Norepinephrine 127-141 monoamine oxidase A Homo sapiens 21-25 27224648-9 2016 A positive correlation was also found between urinary noradrenaline and adrenaline levels and LAT1 gene expression in PHEO. Norepinephrine 54-67 solute carrier family 7 member 5 Homo sapiens 94-98 26891013-3 2016 Dopamine beta-hydroxylase (DbetaH) is a key enzyme that converts dopamine to norepinephrine and for which activity and levels are under strong genetic control. Norepinephrine 77-91 dopamine beta-hydroxylase Homo sapiens 0-25 26891013-3 2016 Dopamine beta-hydroxylase (DbetaH) is a key enzyme that converts dopamine to norepinephrine and for which activity and levels are under strong genetic control. Norepinephrine 77-91 dopamine beta-hydroxylase Homo sapiens 27-33 26428673-0 2016 Resveratrol attenuates norepinephrine-induced ovarian cancer invasiveness through downregulating hTERT expression. Norepinephrine 23-37 telomerase reverse transcriptase Homo sapiens 97-102 26790973-9 2016 In contrast, early postoperative parameters revealed a higher correlation with the occurrence of mesenteric ischemia including the use of norepinephrine (OR 3.5 CI95% 1.6-7.8), epinephrine (OR 2.0, CI95% 1.1-3.7), and serum lactate levels >3 mmol/L (OR 2.9, CI95% 1.5-5.6). Norepinephrine 138-152 olfactory receptor family 5 subfamily H member 4 pseudogene Homo sapiens 154-160 25482049-3 2016 Recent studies show an important role of prefrontal cortical iPLA2 in hippocampo-prefrontal cortical LTP and antidepressant-like effect of the norepinephrine reuptake inhibitor (NRI) antidepressant, maprotiline. Norepinephrine 143-157 patatin like phospholipase domain containing 2 Homo sapiens 61-66 25482049-8 2016 Together, results indicate that stimulation of adrenoreceptors causes increased iPLA2 expression via MAP kinase/ERK 1/2 and SREBP, and suggest a possible mechanism for effect of CNS noradrenaline on neural plasticity and crosstalk between sterol and glycerophospholipid mediators, that may play a role in physiological or pathophysiological processes in the brain and other organs. Norepinephrine 182-195 patatin like phospholipase domain containing 2 Homo sapiens 80-85 26008896-2 2015 Neuropeptide Y (NPY) is a neurotransmitter that is co-released with norepinephrine and is up-regulated during increased sympathetic activity. Norepinephrine 68-82 neuropeptide Y Homo sapiens 0-14 26008896-2 2015 Neuropeptide Y (NPY) is a neurotransmitter that is co-released with norepinephrine and is up-regulated during increased sympathetic activity. Norepinephrine 68-82 neuropeptide Y Homo sapiens 16-19 26523867-2 2015 Here we found that the transcription factor Nr4a1 regulated the production of norepinephrine (NE) in macrophages and thereby limited experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. Norepinephrine 78-92 nuclear receptor subfamily 4, group A, member 1 Mus musculus 44-49 26459348-7 2015 Treatment of mice housed at 22 C with a beta2-adrenergic antagonist reverses the norepinephrine-driven suppression of GVHD and yields similar disease to mice housed at 30 C. Conversely, administering a beta2-adrenergic agonist decreases GVHD in mice housed at 30 C. In further mechanistic studies using beta2-adrenergic receptor-deficient (beta2-AR(-/-)) mice, we found that it is host cell beta2-AR signaling that is essential for decreasing GVHD. Norepinephrine 81-95 adrenergic receptor, beta 2 Mus musculus 303-328 26459348-7 2015 Treatment of mice housed at 22 C with a beta2-adrenergic antagonist reverses the norepinephrine-driven suppression of GVHD and yields similar disease to mice housed at 30 C. Conversely, administering a beta2-adrenergic agonist decreases GVHD in mice housed at 30 C. In further mechanistic studies using beta2-adrenergic receptor-deficient (beta2-AR(-/-)) mice, we found that it is host cell beta2-AR signaling that is essential for decreasing GVHD. Norepinephrine 81-95 adrenergic receptor, beta 2 Mus musculus 340-348 26459348-7 2015 Treatment of mice housed at 22 C with a beta2-adrenergic antagonist reverses the norepinephrine-driven suppression of GVHD and yields similar disease to mice housed at 30 C. Conversely, administering a beta2-adrenergic agonist decreases GVHD in mice housed at 30 C. In further mechanistic studies using beta2-adrenergic receptor-deficient (beta2-AR(-/-)) mice, we found that it is host cell beta2-AR signaling that is essential for decreasing GVHD. Norepinephrine 81-95 adrenergic receptor, beta 2 Mus musculus 391-399 26144997-0 2015 Noradrenaline modulates the presence of gonadotropin-releasing hormone in ovary. Norepinephrine 0-13 gonadotropin releasing hormone 1 Rattus norvegicus 40-70 26173457-7 2015 Within the adrenal medulla, pendrin localizes to both epinephrine- and norepinephrine-producing chromaffin cells. Norepinephrine 71-85 solute carrier family 26, member 4 Mus musculus 28-35 26173457-11 2015 With 20 min of immobilization stress, epinephrine and norepinephrine concentrations increased more in pendrin-null than in wild-type mice, although stress produced a similar increase in blood pressure in both groups. Norepinephrine 54-68 solute carrier family 26, member 4 Mus musculus 102-109 26004513-8 2015 P2X1 receptors mediate the vasocontractile actions of ATP released as a neurotransmitter with noradrenaline (NA) from sympathetic perivascular nerves, and are located on the vascular smooth muscle adjacent to the nerve varicosities, the sites of neurotransmitter release. Norepinephrine 94-107 purinergic receptor P2X 1 Homo sapiens 0-4 26002194-0 2015 Life-long norepinephrine transporter (NET) knock-out leads to the increase in the NET mRNA in brain regions rich in norepinephrine terminals. Norepinephrine 10-24 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 38-41 26002194-0 2015 Life-long norepinephrine transporter (NET) knock-out leads to the increase in the NET mRNA in brain regions rich in norepinephrine terminals. Norepinephrine 10-24 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 82-85 26002194-5 2015 Surprisingly, the studies have shown that the mRNA encoding NET accumulated in the brain regions rich in norepinephrine nerve endings in the NET-KO mice. Norepinephrine 105-119 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 60-63 26002194-5 2015 Surprisingly, the studies have shown that the mRNA encoding NET accumulated in the brain regions rich in norepinephrine nerve endings in the NET-KO mice. Norepinephrine 105-119 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 141-144 26058426-4 2015 Treatments with norepinephrine (beta2-adrenoreceptor agonist) in mice xenografted with human DU145 prostate cancer cells increased the metastatic potential of these cells. Norepinephrine 16-30 adrenergic receptor, beta 2 Mus musculus 32-52 25581910-8 2015 CPM induced the release of norepinephrine in the spinal cord and was partially blocked by intrathecal idazoxan or dopamine beta-hydroxylase-saporin. Norepinephrine 27-41 dopamine beta-hydroxylase Rattus norvegicus 114-139 25799564-9 2015 It was observed that when alpha1B-adrenergic receptors were stimulated with noradrenaline, the receptors interacted with proteins present in early endosomes, such as the early endosomes antigen 1, Rab 5, Rab 4, and Rab 11 but not with late endosome markers, such as Rab 9 and Rab 7. Norepinephrine 76-89 RAB5A, member RAS oncogene family Homo sapiens 197-202 25498793-6 2015 CCI also induced a norepinephrine-triggered nociception that was inhibited by an alpha-adrenoceptor antagonist, norepinephrine transporter block and monoamine oxidase inhibition. Norepinephrine 19-33 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 112-138 24809685-10 2015 However, the presently observed trend towards CpG-specific MAO-A gene hypomethylation-possibly via increased gene expression and consecutively decreased serotonin and/or norepinephrine availability-to potentially drive impaired antidepressant treatment response in female patients might be worthwhile to be followed up in larger pharmacoepigenetic studies. Norepinephrine 170-184 monoamine oxidase A Homo sapiens 59-64 25506603-9 2015 This review uses the major brain norepinephrine system as a model stress-response system to demonstrate how co-regulation by opposing pro-stress (corticotropin-releasing factor) and anti-stress (enkephalin) neuromodulators must be fine-tuned to produce an adaptive response to stress. Norepinephrine 33-47 corticotropin releasing hormone Homo sapiens 146-176 25584932-4 2015 Black and Hispanic populations are known to have a higher prevalence of cardiovascular risk factors and disease, and a substantial proportion of black and Hispanic individuals possess genotypes of the cytochrome P450 (CYP) 2C9 enzyme involved in the metabolism of many NSAIDs and the CYP2D6 enzyme involved in metabolism of the dual opioid agonist/norepinephrine-serotonin reuptake inhibitor tramadol. Norepinephrine 348-362 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 201-226 25326128-1 2014 RATIONALE: Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine in the central nervous system and peripherally. Norepinephrine 83-97 dopamine beta-hydroxylase Homo sapiens 11-36 25326128-1 2014 RATIONALE: Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine in the central nervous system and peripherally. Norepinephrine 83-97 dopamine beta-hydroxylase Homo sapiens 38-41 24803315-0 2014 The stress-related hormone norepinephrine induced upregulation of Nix, contributing to ECM protein expression. Norepinephrine 27-41 multimerin 1 Homo sapiens 87-90 25131562-8 2014 Triple-labeling immunocytochemistry revealed that alpha2A-AR and CB1R were localised to processes that contained dopamine-beta-hydroxylase, a marker of norepinephrine. Norepinephrine 152-166 dopamine beta-hydroxylase Rattus norvegicus 113-138 25009110-3 2014 The norepinephrine system originating mainly in the locus coeruleus (LC) is defective in Rett syndrome and Mecp2-null mice. Norepinephrine 4-18 methyl CpG binding protein 2 Mus musculus 107-112 25187989-2 2014 In the current study we demonstrate that the noradrenalin analogue octopamine and the cholecystokinin (CCK) homologue Drosulfakinin (Dsk) function downstream of TfAP-2 and Tiwaz (Twz) to control the number of meals in adult flies. Norepinephrine 45-57 Transcription factor AP-2 Drosophila melanogaster 161-167 24870806-2 2014 Norepinephrine (NE) released from these neurons is reported to augment antibody production in response to an immune challenge via an action at the beta2-adrenergic receptor (beta2AR). Norepinephrine 0-14 adrenergic receptor, beta 2 Mus musculus 147-172 24870806-2 2014 Norepinephrine (NE) released from these neurons is reported to augment antibody production in response to an immune challenge via an action at the beta2-adrenergic receptor (beta2AR). Norepinephrine 0-14 adrenergic receptor, beta 2 Mus musculus 174-181 24951589-4 2014 The contractile responses of arteries from knock-out mice to norepinephrine were inhibited by Rho-associated kinase (ROCK) and protein kinase C inhibitors and were associated with inhibition of phosphorylation of the myosin light chain phosphatase inhibitor CPI-17. Norepinephrine 61-75 protein phosphatase 1, regulatory inhibitor subunit 14A Mus musculus 258-264 24780611-4 2014 APN intracerebroventricular infusions decreased uncoupling protein 1 (UCP1) expression in brown adipose tissue, epinephrine and norepinephrine serum levels, and osteoclast numbers, whereas osteoblast osteogenic marker expression and trabecular bone mass increased in APN-KO and WT mice. Norepinephrine 128-142 adiponectin, C1Q and collagen domain containing Mus musculus 0-3 24168152-1 2014 AIMS: Etamicastat is a reversible dopamine-beta-hydroxylase inhibitor that decreases noradrenaline levels in sympathetically innervated tissues and slows down sympathetic nervous system drive. Norepinephrine 85-98 dopamine beta-hydroxylase Homo sapiens 34-59 24607627-7 2014 We then demonstrated that MAOA suppressed norepinephrine/epinephrine (NE/E)-induced HCC invasion and anoikis inhibition, and uncovered that the effects of NE/E on HCC behaviors were primarily mediated through alpha 1A (ADRA1A) and beta 2 adrenergic receptors (ADRB2). Norepinephrine 42-56 monoamine oxidase A Homo sapiens 26-30 25039112-0 2014 Effect of neuropeptide Y on norepinephrine-induced constriction in the rabbit facial artery after carotid artery occlusion. Norepinephrine 28-42 neuropeptide Y Oryctolagus cuniculus 10-24 24440144-0 2014 The sympathetic nervous system modulates CD4(+)Foxp3(+) regulatory T cells via noradrenaline-dependent apoptosis in a murine model of lymphoproliferative disease. Norepinephrine 79-92 forkhead box P3 Mus musculus 47-52 24510409-1 2014 Monoamine oxidase A (MAOA) catalyzes monoamine neurotransmitters including dopamine, 5-hydroxytryptamine (5-HT, serotonin), and norepinephrine. Norepinephrine 128-142 monoamine oxidase A Homo sapiens 21-25 24465756-4 2014 Since norepinephrine affects motility of EHEC O157:H7 through a qseBC-encoded two-component quorum sensing signaling, we also determined whether the hha-mediated regulation of motility is affected by norepinephrine and whether this effect is qseBC dependent. Norepinephrine 200-214 H-HA Escherichia coli 149-152 24328808-2 2014 In this paper, we review work from our laboratory and others focused on determining the neurobiological mechanisms that underlie and contribute to stress-induced relapse of cocaine use with an emphasis on the actions of corticotropin-releasing factor in the ventral tegmental area (VTA) and a key pathway from the bed nucleus of the stria terminalis to the VTA that is regulated by norepinephrine and beta adrenergic receptors. Norepinephrine 382-396 corticotropin releasing hormone Homo sapiens 220-250 24075956-1 2013 Uptake of norepinephrine via the neuronal norepinephrine transporter is reduced in the heart during deoxycorticosterone (DOCA)-salt hypertension. Norepinephrine 10-24 solute carrier family 6 member 2 Rattus norvegicus 42-68 24068832-1 2013 Inhibitors of dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine (DA) to norepinephrine (NE) in noradrenergic cells, have shown promise for the treatment of cocaine abuse disorders. Norepinephrine 89-103 dopamine beta-hydroxylase Rattus norvegicus 14-39 24068832-1 2013 Inhibitors of dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine (DA) to norepinephrine (NE) in noradrenergic cells, have shown promise for the treatment of cocaine abuse disorders. Norepinephrine 89-103 dopamine beta-hydroxylase Rattus norvegicus 41-44 23416088-2 2013 Dopamine beta-hydroxylase (DBH) as a catecholamine-synthesizing enzyme plays a central role in noradrenaline (NA) synthesis and turnover. Norepinephrine 95-108 dopamine beta-hydroxylase Homo sapiens 0-25 23416088-2 2013 Dopamine beta-hydroxylase (DBH) as a catecholamine-synthesizing enzyme plays a central role in noradrenaline (NA) synthesis and turnover. Norepinephrine 95-108 dopamine beta-hydroxylase Homo sapiens 27-30 23539726-12 2013 CONCLUSION: This case represents the first association of a somatic HIF2A gain-of-function mutation with PHEO and congenital polycythemia, and it alerts physicians to perform proper genetic screening in patients presenting with multiple norepinephrine-producing PHEOs and polycythemia. Norepinephrine 237-251 endothelial PAS domain protein 1 Homo sapiens 68-73 23510745-1 2013 By balancing the ratios of dopamine and norepinephrine, dopamine beta hydroxylase (DBH) plays an important role in brain reward circuit that is involved with behavioral effects of heroin addiction. Norepinephrine 40-54 dopamine beta-hydroxylase Homo sapiens 56-81 23510745-1 2013 By balancing the ratios of dopamine and norepinephrine, dopamine beta hydroxylase (DBH) plays an important role in brain reward circuit that is involved with behavioral effects of heroin addiction. Norepinephrine 40-54 dopamine beta-hydroxylase Homo sapiens 83-86 23571809-9 2013 A partial correlation network showed total tau most directly related to norepinephrine and purine pathways; amyloid-beta (Ab42) was related directly to an unidentified metabolite and indirectly to 5-HIAA and MET. Norepinephrine 72-86 microtubule associated protein tau Homo sapiens 43-46 23478410-6 2013 Moreover, HSPC motility was regulated by norepinephrine and insulin-like growth factor-1 (IGF-1), which increased or reduced, respectively, GSK3beta expression in BM HSPCs and their subsequent egress. Norepinephrine 41-55 glycogen synthase kinase 3 beta Mus musculus 140-148 25390808-0 2013 Acute macular neuroretinopathy associated with the use of norepinephrine reuptake inhibitors: a case series and OCT findings. Norepinephrine 58-72 plexin A2 Homo sapiens 112-115 23231070-5 2013 More recently, AI-3 and the host neuroendocrine (NE) hormones adrenaline and noradrenaline were reported to display cross-talk for the activation of the same signalling pathways. Norepinephrine 77-90 family with sequence similarity 83 member H Homo sapiens 15-19 23805714-1 2013 Peptides of the insulin superfamily (insulin, insulin-like growth factor, relaxin), epidermal.growth factor (ECF) and biogenic amines (isoproterenol, adrenalin, noradrenalin, serotonin) stimulate the adenylyl cyclase signaling system (ACSS). Norepinephrine 161-173 epidermal growth factor Homo sapiens 84-107 23469282-6 2013 Here, we examined the expression profile of the HDAC protein family from HDAC1 to HDAC11 in corticotropin-releasing hormone, oxytocin, vasopressin, agouti-related peptide (AgRP), pro-opiomelanocortin (POMC), orexin, histamine, dopamine, serotonin, and noradrenaline neurons. Norepinephrine 252-265 histone deacetylase 11 Homo sapiens 82-88 22923736-7 2012 Indeed, selective H(3) and H(4) receptor agonists each synergized with a PKG inhibitor and a PDE3 activator in attenuating BNP-induced norepinephrine release from cardiac sympathetic nerve endings. Norepinephrine 135-149 phosphodiesterase 4D, cAMP-specific-like 1 Rattus norvegicus 93-97 22837346-1 2012 Norepinephrine (NE) amplifies the mitogenic effect of EGF in a rat liver through the adrenergic receptor coupled with G protein, Ghalpha. Norepinephrine 0-14 epidermal growth factor Rattus norvegicus 54-57 22761303-6 2012 ALDH2 activation substantially reduced acetaldehyde- and hypoxia-induced norepinephrine release, an action prevented by inhibition of ALDH2 or protein kinase Cepsilon (PKCepsilon). Norepinephrine 73-87 aldehyde dehydrogenase 2 family member Rattus norvegicus 0-5 22761303-6 2012 ALDH2 activation substantially reduced acetaldehyde- and hypoxia-induced norepinephrine release, an action prevented by inhibition of ALDH2 or protein kinase Cepsilon (PKCepsilon). Norepinephrine 73-87 aldehyde dehydrogenase 2 family member Rattus norvegicus 134-139 22761303-12 2012 This pathway comprises the sequential activation of PKCepsilon and ALDH2, culminating in aldehyde detoxification and inhibition of hypoxic norepinephrine release. Norepinephrine 139-153 aldehyde dehydrogenase 2 family member Rattus norvegicus 67-72 22761303-13 2012 Thus, pharmacological activation of PKCepsilon and ALDH2 in cardiac sympathetic nerves may have significant protective effects by alleviating norepinephrine-induced life-threatening arrhythmias that characterize myocardial ischemia/reperfusion. Norepinephrine 142-156 aldehyde dehydrogenase 2 family member Rattus norvegicus 51-56 23675273-1 2012 Dopoamine-beta-hydroxylase (DBH) is a catecholamine-synthesizing enzyme which catalyzes the formation of norepinephrine from dopamine. Norepinephrine 105-119 dopamine beta-hydroxylase Rattus norvegicus 0-26 23675273-1 2012 Dopoamine-beta-hydroxylase (DBH) is a catecholamine-synthesizing enzyme which catalyzes the formation of norepinephrine from dopamine. Norepinephrine 105-119 dopamine beta-hydroxylase Rattus norvegicus 28-31 22739762-2 2012 Norepinephrine is routinely administered to maintain cerebral perfusion pressure and, thereby, cerebral blood flow, but norepinephrine reduces the scO2. Norepinephrine 120-134 synthesis of cytochrome C oxidase 2 Homo sapiens 147-151 22739762-3 2012 We hypothesized that norepinephrine-induced reduction in scO2 is influenced by cutaneous vasoconstriction. Norepinephrine 21-35 synthesis of cytochrome C oxidase 2 Homo sapiens 57-61 22698264-5 2012 Tapentadol"s MOR agonist activity is several-fold greater than tramadol"s, with prominent norepinephrine reuptake inhibition and minimal serotonin effect. Norepinephrine 90-104 opioid receptor mu 1 Homo sapiens 13-16 22426196-7 2012 Despite this unusual topography, AmAC2t-activity could be stimulated by norepinephrine and NKH477 with EC(50s) of 0.07 muM and 3 muM. Norepinephrine 72-86 adenylate cyclase type 2 Apis mellifera 33-38 22192161-1 2012 Tapentadol is a newly approved novel analgesic drug with a dual mode of action: a mu-opioid agonist and an inhibitor of norepinephrine reuptake (MOR-NRI). Norepinephrine 120-134 opioid receptor mu 1 Homo sapiens 145-148 22093159-10 2012 Up-regulation of the sympathetic repellent semaphorin 3F in the polyps possibly triggers sympathetic repulsion and polyp growth due to the loss of anti-proliferative noradrenaline and presence of SP from local SP+ cells. Norepinephrine 166-179 semaphorin 3F Homo sapiens 43-56 22172866-1 2011 INTRODUCTION: Renalase, an enzyme that breaks down catecholamines like adrenaline and noradrenaline in the blood circulation, was discovered in 2005. Norepinephrine 86-99 renalase, FAD dependent amine oxidase Homo sapiens 14-22 22101429-3 2011 Acting via the beta(3)-adrenergic receptors, noradrenaline induces lipolysis in white adipocytes, whereas it stimulates the expression of thermogenic genes, such as PPAR-gamma coactivator 1a (Ppargc1a), uncoupling protein 1 (Ucp1) and acyl-CoA synthetase long-chain family member 1 (Acsl1), in brown adipocytes. Norepinephrine 45-58 uncoupling protein 1 Homo sapiens 203-223 22101429-3 2011 Acting via the beta(3)-adrenergic receptors, noradrenaline induces lipolysis in white adipocytes, whereas it stimulates the expression of thermogenic genes, such as PPAR-gamma coactivator 1a (Ppargc1a), uncoupling protein 1 (Ucp1) and acyl-CoA synthetase long-chain family member 1 (Acsl1), in brown adipocytes. Norepinephrine 45-58 uncoupling protein 1 Homo sapiens 225-229 22015761-5 2011 Brainstem sections were immunohistochemically processed for dopamine-beta-hydroxylase, a marker for norepinephrine. Norepinephrine 100-114 dopamine beta-hydroxylase Rattus norvegicus 60-85 21943397-0 2011 CFTR mediates noradrenaline-induced ATP efflux from DRG neurons. Norepinephrine 14-27 CF transmembrane conductance regulator Rattus norvegicus 0-4 21943397-1 2011 In our earlier study, noradrenaline (NA) stimulated ATP release from dorsal root ganglion (DRG) neurons as mediated via beta(3) adrenoceptors linked to G(s) protein involving protein kinase A (PKA) activation, to cause allodynia. Norepinephrine 22-35 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 175-191 21943397-1 2011 In our earlier study, noradrenaline (NA) stimulated ATP release from dorsal root ganglion (DRG) neurons as mediated via beta(3) adrenoceptors linked to G(s) protein involving protein kinase A (PKA) activation, to cause allodynia. Norepinephrine 22-35 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 193-196 21521766-5 2011 Presynaptic injection of NT or AID peptide into SCGN synapses inhibited synaptic transmission and also attenuated noradrenaline-induced G protein modulation. Norepinephrine 114-127 secretagogin, EF-hand calcium binding protein Homo sapiens 48-52 21347840-7 2011 On the other hand, agents that mobilize Ca(2+) from endoplasmic reticulum such as noradrenaline or thapsigargin, induced Bax translocation, while mitochondrial Ca(2+) release evoked by carbonyl cyanide-p-(trifluoromethoxyphenyl) hydrazone was not able to cause Bax punctation. Norepinephrine 82-95 BCL2 associated X, apoptosis regulator Rattus norvegicus 121-124 21347840-7 2011 On the other hand, agents that mobilize Ca(2+) from endoplasmic reticulum such as noradrenaline or thapsigargin, induced Bax translocation, while mitochondrial Ca(2+) release evoked by carbonyl cyanide-p-(trifluoromethoxyphenyl) hydrazone was not able to cause Bax punctation. Norepinephrine 82-95 BCL2 associated X, apoptosis regulator Rattus norvegicus 261-264 20810002-1 2011 BACKGROUND: Monoamine oxidase A (MAOA) is an important enzyme that metabolizes monoamines such as serotonin, norepinephrine and dopamine in the brain. Norepinephrine 109-123 monoamine oxidase A Homo sapiens 12-31 20810002-1 2011 BACKGROUND: Monoamine oxidase A (MAOA) is an important enzyme that metabolizes monoamines such as serotonin, norepinephrine and dopamine in the brain. Norepinephrine 109-123 monoamine oxidase A Homo sapiens 33-37 21525270-6 2011 We conclude that Hcrt-r2 is a vital element in a feedback loop integrating Hcrt, acetylcholine, and norepinephrine function. Norepinephrine 100-114 hypocretin receptor 2 Canis lupus familiaris 17-24 21525270-6 2011 We conclude that Hcrt-r2 is a vital element in a feedback loop integrating Hcrt, acetylcholine, and norepinephrine function. Norepinephrine 100-114 hypocretin neuropeptide precursor Canis lupus familiaris 17-21 21572590-4 2011 More specifically, we demonstrate that noradrenaline used locally within V1 mediates the light-driven gene expression of egr-1, an immediate early gene implicated as a mediator of neuronal plasticity. Norepinephrine 39-52 early growth response 1 Mus musculus 121-126 21302344-2 2011 Well-characterized common functional polymorphisms in the genes MAOA, COMT, and 5HTTLPR each have predictable effects on the availability of the monoamine neurotransmitters dopamine, noradrenaline, and serotonin. Norepinephrine 183-196 monoamine oxidase A Homo sapiens 64-68 20890184-9 2011 MEASUREMENTS AND MAIN RESULTS: Compared with single norepinephrine therapy, the selective V1aR agonist Phe2-Orn8-Vasotocin reduced norepinephrine requirements (2-6 hrs: p < .05 each) and fluid accumulation (p = .043). Norepinephrine 131-145 vasopressin V1a receptor Ovis aries 90-94 20890184-14 2011 In addition, the selective V1aR agonist Phe2-Orn8-Vasotocin slightly prolonged survival when compared with arginine vasopressin (p = .01) and standard treatment with norepinephrine (p = .003). Norepinephrine 166-180 vasopressin V1a receptor Ovis aries 27-31 20858707-4 2010 hPMAT is highly selective toward serotonin (5-HT) and dopamine, with the rank order of transport efficiency (V(max)/K(m)) being: dopamine, 5-HT >> histamine, norepinephrine, epinephrine. Norepinephrine 164-178 solute carrier family 29 member 4 Homo sapiens 0-5 20800684-4 2010 In the first study, E and the ERalpha agonist increased norepinephrine in cortex and all three ER ligands increased it in the ventral hippocampus. Norepinephrine 56-70 estrogen receptor 1 Rattus norvegicus 30-37 20144675-5 2010 Likewise, norepinephrine-depletion increased neuroinflammation compared to transgenic controls as verified by macrophage inflammatory protein-1alpha and -1beta gene expression analysis. Norepinephrine 10-24 chemokine (C-C motif) ligand 3 Mus musculus 110-159 20728435-5 2010 A small number of HSD2 immunoreactive neurons was also labeled for dopamine-beta-hydroxylase (DBH), an enzyme involved in norepinephrine biosynthesis. Norepinephrine 122-136 dopamine beta-hydroxylase Rattus norvegicus 94-97 20729197-1 2010 alpha(2)-Adrenoceptors belong to the family of adrenergic receptors, which regulate the neuronal release of norepinephrine as part of a negative feedback loop. Norepinephrine 108-122 adrenergic receptor, alpha 2b Mus musculus 0-22 20600439-5 2010 In both cases, the effect on norepinephrine uptake was coupled to protein kinase A and C as well as nitric oxide pathways. Norepinephrine 29-43 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 66-82 20597975-8 2010 Of these, norepinephrine neurotransmission in the arcuate nucleus and prefrontal cortex was differentially altered in GHSR KO mice. Norepinephrine 10-24 growth hormone secretagogue receptor Mus musculus 118-122 20448147-1 2010 A neurotransmitter, norepinephrine (NE), amplifies the mitogenic effect of epidermal growth factor (EGF) in the liver by acting on the alpha(1)-adrenergic receptor coupled with G protein, Galpha(h). Norepinephrine 20-34 epidermal growth factor Homo sapiens 75-98 20448147-1 2010 A neurotransmitter, norepinephrine (NE), amplifies the mitogenic effect of epidermal growth factor (EGF) in the liver by acting on the alpha(1)-adrenergic receptor coupled with G protein, Galpha(h). Norepinephrine 20-34 succinate-CoA ligase GDP/ADP-forming subunit alpha Homo sapiens 188-194 20402963-6 2010 However, OCT3 was determined to be a high-capacity and low-affinity transporter for the neurotransmitters dopamine (DA), norepinephrine (NE), and serotonin (5-HT). Norepinephrine 121-135 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 9-13 20420875-5 2010 Lack of alpha-synuclein did not modify the relaxant responses to the endothelium-dependent (acetylcholine) and -independent (sodium nitroprusside) vasodilators, but resulted in a greater than normal norepinephrine-induced vasoconstriction along with a lowered response to dopamine, suggesting potential presynaptic changes in dopamine and norepinephrine releases in knockout mice. Norepinephrine 199-213 synuclein, alpha Mus musculus 8-23 20430042-6 2010 Homozygosity for the DBH T allele, which is associated with relatively increased dopamine and decreased noradrenaline levels, resulted in a significant increase in rightwards spatial bias relative to the C allele. Norepinephrine 104-117 dopamine beta-hydroxylase Homo sapiens 21-24 20388489-6 2010 Unlike the other members of the mitochondrial carrier superfamily, the eutherian uncoupling protein UCP1 has evolved to achieve its heat-generating capacity in the physiological context provided by the brown adipocyte and therefore it is activated by the low fatty acid concentrations generated by the noradrenaline-stimulated lipolysis. Norepinephrine 302-315 uncoupling protein 1 Homo sapiens 100-104 20215412-0 2010 Transmembrane segment five serines of the D4 dopamine receptor uniquely influence the interactions of dopamine, norepinephrine, and Ro10-4548. Norepinephrine 112-126 dopamine receptor D4 Homo sapiens 42-62 20193756-0 2010 Noradrenaline acting at central beta-adrenoceptors induces interleukin-10 and suppressor of cytokine signaling-3 expression in rat brain: implications for neurodegeneration. Norepinephrine 0-13 interleukin 10 Rattus norvegicus 59-112 20193756-3 2010 Administration of the noradrenaline reuptake inhibitor reboxetine (15mg/kg; ip) combined with the alpha(2)-adrenoceptor antagonist idazoxan (1mg/kg; ip) induced interleukin-10 (IL-10) expression in rat cortex and hippocampus. Norepinephrine 22-35 interleukin 10 Rattus norvegicus 161-175 20193756-3 2010 Administration of the noradrenaline reuptake inhibitor reboxetine (15mg/kg; ip) combined with the alpha(2)-adrenoceptor antagonist idazoxan (1mg/kg; ip) induced interleukin-10 (IL-10) expression in rat cortex and hippocampus. Norepinephrine 22-35 interleukin 10 Rattus norvegicus 177-182 20132473-0 2010 Regulation of MCP-1 production in brain by stress and noradrenaline-modulating drugs. Norepinephrine 54-67 C-C motif chemokine ligand 2 Rattus norvegicus 14-19 19961846-0 2010 Presynaptic BK type Ca(2+)-activated K(+) channels are involved in prostanoid TP receptor-mediated inhibition of noradrenaline release from the rat gastric sympathetic nerves. Norepinephrine 113-126 thromboxane A2 receptor Rattus norvegicus 67-89 19961846-1 2010 Previously, we reported that prostanoid TP receptor mediates the inhibition of electrically evoked noradrenaline release from gastric sympathetic nerves in rats. Norepinephrine 99-112 thromboxane A2 receptor Rattus norvegicus 29-51 19961846-6 2010 These results suggest that BK type Ca(2+)-activated K(+) channels are involved in prostanoid TP receptor-mediated inhibition of electrically evoked noradrenaline release from the gastric sympathetic nerve terminals in rats. Norepinephrine 148-161 thromboxane A2 receptor Rattus norvegicus 82-104 20042730-12 2010 These results indicate that there are several electrophysiological abnormalities in LC neurons of Mecp2(-/Y) mice, which may contribute to the dysfunction of the norepinephrine system in Rett syndrome. Norepinephrine 162-176 methyl CpG binding protein 2 Mus musculus 98-103 20036056-0 2010 Nociceptin/Orphanin FQ in PAG modulates the release of amino acids, serotonin and norepinephrine in the rostral ventromedial medulla and spinal cord in rats. Norepinephrine 82-96 prepronociceptin Rattus norvegicus 0-10 20036056-0 2010 Nociceptin/Orphanin FQ in PAG modulates the release of amino acids, serotonin and norepinephrine in the rostral ventromedial medulla and spinal cord in rats. Norepinephrine 82-96 prepronociceptin Rattus norvegicus 11-22 19909795-2 2010 This study explored whether hormone regulation/dysregulation of these systems could be related to gonadal steroid effects on catechol-O-methyltransferase and monoamine oxidase which are principal enzymatic controllers of forebrain dopamine, serotonin and norepinephrine levels. Norepinephrine 255-269 catechol-O-methyltransferase Rattus norvegicus 125-153 19854260-5 2010 Noradrenaline (1 microM), adrenaline (1 microM), and dopamine (100 microM) showed a maximal increase in NT-3 cellular content after 6h treatment causing a 1.9-, 1.8- and 2.7-fold elevation, respectively. Norepinephrine 0-13 neurotrophin 3 Rattus norvegicus 104-108 19854260-6 2010 Prior to the observed increase in NT-3 protein levels, the examined catecholamines increased NT-3 mRNA levels with maximal effects observed after 1h (noradrenaline) and 2h (adrenaline and dopamine) of incubation causing 2.4-, 2.6- and 3-fold elevation, respectively. Norepinephrine 150-163 neurotrophin 3 Rattus norvegicus 93-97 19914944-11 2010 UCN2 also induced a short-lived rise in plasma norepinephrine levels (P=0.006). Norepinephrine 47-61 urocortin-2 Ovis aries 0-4 21171669-2 2010 A strategy for directly modulating sympathetic nerve function is to reduce the biosynthesis of norepinephrine (noradrenaline) via inhibition of dopamine-beta-hydroxylase (DbetaH). Norepinephrine 95-109 dopamine beta-hydroxylase Homo sapiens 144-169 21171669-2 2010 A strategy for directly modulating sympathetic nerve function is to reduce the biosynthesis of norepinephrine (noradrenaline) via inhibition of dopamine-beta-hydroxylase (DbetaH). Norepinephrine 111-124 dopamine beta-hydroxylase Homo sapiens 144-169 19860854-3 2010 The initiation of Aanat transcription at night is controlled largely by the norepinephrine-stimulated phosphorylation of cAMP response element-binding protein by protein kinase A. Norepinephrine 76-90 aralkylamine N-acetyltransferase Rattus norvegicus 18-23 23675164-1 2009 Dopamine-beta-hydroxylase (DBH) is a neurotransmitter synthesizing enzyme which catalyzes the formation of norepinephrine from dopamine. Norepinephrine 107-121 dopamine beta-hydroxylase Homo sapiens 0-25 23675164-1 2009 Dopamine-beta-hydroxylase (DBH) is a neurotransmitter synthesizing enzyme which catalyzes the formation of norepinephrine from dopamine. Norepinephrine 107-121 dopamine beta-hydroxylase Homo sapiens 27-30 19693491-19 2009 Both PDE3 and PDE4 control atrial and ventricular positive inotropic effects of (-)-noradrenaline. Norepinephrine 80-97 phosphodiesterase 4D, cAMP-specific-like 1 Rattus norvegicus 5-9 19482560-1 2009 In this study we investigated the changes in norepinephrine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) gene expression in the stellate ganglia of naive controls and long-term socially isolated (12 weeks) adult rats and the response of these animals to additional immobilization stress. Norepinephrine 45-59 phenylethanolamine-N-methyltransferase Rattus norvegicus 144-182 19482560-1 2009 In this study we investigated the changes in norepinephrine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) gene expression in the stellate ganglia of naive controls and long-term socially isolated (12 weeks) adult rats and the response of these animals to additional immobilization stress. Norepinephrine 45-59 phenylethanolamine-N-methyltransferase Rattus norvegicus 184-188 19573018-7 2009 Transfection of shRNAs specific to Phox2a or Phox2b genes significantly reduced mRNA and protein levels of NET and DBH after shutdown of endogenous Phox2, which was accompanied by a decreased [(3)H]norepinephrine uptake. Norepinephrine 198-212 dopamine beta-hydroxylase Homo sapiens 115-118 19672024-5 2009 RESULTS: In pheochromocytoma tissue, AdpR1 mRNA expression was higher in adrenaline (A)-type tumors than in noradrenaline (NA)-type tumors. Norepinephrine 108-121 adiponectin receptor 1 Homo sapiens 37-42 19234788-2 2009 Menkes disease can be detected by relatively high concentrations of dopamine (DA) and its metabolites compared to norepinephrine (NE) and its metabolites, presumably because dopamine-beta-hydroxylase (DBH) requires copper as a co-factor. Norepinephrine 114-128 dopamine beta-hydroxylase Homo sapiens 201-204 19470879-3 2009 We found that the beta(2)-adrenoceptor antagonist ICI 118,551 (ICI) evoked a decrease of vascular tone in large pulmonary arteries and reduced the sensitivity of pulmonary arteries toward different contracting agents, eg, norepinephrine, serotonin, or endothelin. Norepinephrine 222-236 adrenergic receptor, beta 2 Mus musculus 18-38 19470879-5 2009 Pharmacological experiments proved that the right shift of the norepinephrine dose-response curve by ICI was mediated via a beta(2)-adrenoceptor/G(i/o) protein-dependent pathway enhancing NO production in the endothelium; these results were corroborated in beta-adrenoceptor and endothelial NO synthase knockout mice where ICI had no effect. Norepinephrine 63-77 adrenergic receptor, beta 2 Mus musculus 124-144 19506905-5 2009 Indeed, a series of recent studies, particularly concentrating on the serotonin and norepinephrine metabolising enzyme, monoamine oxidase A, has emphasised the necessity of examining gene by environmental interactions if the contributions of individual loci are to be understood. Norepinephrine 84-98 monoamine oxidase A Homo sapiens 120-139 19500370-10 2009 RESULTS: In the animals receiving the Sry1 plasmid there were significant increases after 21 days in resting plasma norepinephrine (NE, 27%) and renal tyrosine hydroxylase content (41%, p < .05) compared to controls. Norepinephrine 116-130 sex determining region Y Rattus norvegicus 38-42 19371348-0 2009 Neuropeptide S selectively inhibits the release of 5-HT and noradrenaline from mouse frontal cortex nerve endings. Norepinephrine 60-73 neuropeptide S Mus musculus 0-14 19217831-7 2009 The peak values of IL-6 and IL-8 also correlated positively with the peak values of noradrenaline (r=0.603 and r=0.681, respectively).These results suggest that a pronounced activation of the sympathetic nervous system and the inflammatory response occurs in acute stage of SAH. Norepinephrine 84-97 C-X-C motif chemokine ligand 8 Canis lupus familiaris 28-32 19293728-2 2009 Our previous study showed that the stimulatory effect of norepinephrine on VSMC proliferation is inhibited by D1-like receptors and the D3 dopamine receptor, a member of the D2-like receptor family. Norepinephrine 57-71 dopamine receptor D3 Homo sapiens 136-156 19244246-7 2009 Norepinephrine-mediated depression on neuronal excitability was mediated by activation of TREK-2, a type of two-pore domain K(+) channel, and mutation of the protein kinase A phosphorylation site on TREK-2 channels annulled the effects of norepinephrine. Norepinephrine 0-14 potassium two pore domain channel subfamily K member 10 Homo sapiens 90-96 19244246-7 2009 Norepinephrine-mediated depression on neuronal excitability was mediated by activation of TREK-2, a type of two-pore domain K(+) channel, and mutation of the protein kinase A phosphorylation site on TREK-2 channels annulled the effects of norepinephrine. Norepinephrine 0-14 potassium two pore domain channel subfamily K member 10 Homo sapiens 199-205 19244246-7 2009 Norepinephrine-mediated depression on neuronal excitability was mediated by activation of TREK-2, a type of two-pore domain K(+) channel, and mutation of the protein kinase A phosphorylation site on TREK-2 channels annulled the effects of norepinephrine. Norepinephrine 239-253 potassium two pore domain channel subfamily K member 10 Homo sapiens 90-96 19244246-7 2009 Norepinephrine-mediated depression on neuronal excitability was mediated by activation of TREK-2, a type of two-pore domain K(+) channel, and mutation of the protein kinase A phosphorylation site on TREK-2 channels annulled the effects of norepinephrine. Norepinephrine 239-253 potassium two pore domain channel subfamily K member 10 Homo sapiens 199-205 19244246-8 2009 Our results indicate a novel action mode in which norepinephrine depresses neuronal excitability in the entorhinal cortex by disinhibiting protein kinase A-mediated tonic inhibition of TREK-2 channels. Norepinephrine 50-64 potassium two pore domain channel subfamily K member 10 Homo sapiens 185-191 19178946-8 2009 DBH catalyses the hydroxylation of the important neurotransmitter dopamine into norepinephrine in the presence of both molecular oxygen and a reducing co-substrate. Norepinephrine 80-94 dopamine beta-hydroxylase Homo sapiens 0-3 19190523-3 2009 However, it was found that the widely used 5-HT receptor antagonists NAN-190 (5-HT1A) and SB 269970 (5-HT7) both blocked alpha2-adrenoceptors, and hence depressed inhibitory synaptic potentials and hyperpolarizations evoked by noradrenaline, in these neurons. Norepinephrine 227-240 5-hydroxytryptamine receptor 1A Cavia porcellus 78-84 18781376-2 2009 Here, we investigated the mechanism of hERG K(+) channel current (I(hERG)) blockade expressed in HEK-293 cells by sibutramine HCl, a serotonin-norepinephrine reuptake inhibitor. Norepinephrine 143-157 potassium voltage-gated channel subfamily H member 2 Homo sapiens 39-73 18930727-0 2008 Neurokinin-1 receptor antagonists modulate brain noradrenaline and serotonin interactions. Norepinephrine 49-62 tachykinin receptor 1 Rattus norvegicus 0-21 19120146-9 2008 Positive association was found between baseline concentrations of norepinephrine and PAI-1 (r= 0.418, P= 0.02). Norepinephrine 66-80 serpin family E member 1 Homo sapiens 85-90 18418364-4 2008 Reduced NET expression resulted in reduced norepinephrine uptake, measured in vitro, and increased noradrenergic neurotransmission, measured in vivo using microdialysis. Norepinephrine 43-57 solute carrier family 6 member 2 Rattus norvegicus 8-11 18981694-1 2008 Catecholamines, namely, dopamine, norepinephrine and epinephrine, play important roles in higher animals as neurotransmitters or hormones, and are metabolized by catechol-O-methyltransferase (COMT). Norepinephrine 34-48 catechol-O-methyltransferase Rattus norvegicus 162-190 18981694-1 2008 Catecholamines, namely, dopamine, norepinephrine and epinephrine, play important roles in higher animals as neurotransmitters or hormones, and are metabolized by catechol-O-methyltransferase (COMT). Norepinephrine 34-48 catechol-O-methyltransferase Rattus norvegicus 192-196 18840973-2 2008 They include transporters for norepinephrine, dopamine and serotonin, which are encoded by the SLC6A2, SLC6A3, and SLC6A4 genes, respectivily. Norepinephrine 30-44 solute carrier family 6 member 3 Canis lupus familiaris 103-109 18772255-0 2008 Intra-amygdala injections of CREB antisense impair inhibitory avoidance memory: role of norepinephrine and acetylcholine. Norepinephrine 88-102 cAMP responsive element binding protein 1 Rattus norvegicus 29-33 18772255-7 2008 In addition, CREB antisense infusions dampened the training-related release of norepinephrine, and to a lesser extent of acetylcholine, in the amygdala. Norepinephrine 79-93 cAMP responsive element binding protein 1 Rattus norvegicus 13-17 18772255-9 2008 These findings suggest that intra-amygdala treatment with CREB antisense may affect processes involved in modulation of memory in part through interference with norepinephrine and acetylcholine neurotransmission in the amygdala. Norepinephrine 161-175 cAMP responsive element binding protein 1 Rattus norvegicus 58-62 18480676-3 2008 Among these are several genes associated with the catecholaminergic system including the dopamine receptor genes (DRD4 and DRD5), the dopamine transporter gene, and the gene for dopamine beta-hydroxylase, which catalyzes conversion of dopamine to norepinephrine. Norepinephrine 247-261 dopamine receptor D4 Homo sapiens 114-118 18480676-3 2008 Among these are several genes associated with the catecholaminergic system including the dopamine receptor genes (DRD4 and DRD5), the dopamine transporter gene, and the gene for dopamine beta-hydroxylase, which catalyzes conversion of dopamine to norepinephrine. Norepinephrine 247-261 dopamine beta-hydroxylase Homo sapiens 178-203 18463263-1 2008 The genetic deletion of monoamine oxidase A (MAO A), an enzyme that breaks down the monoamine neurotransmitters norepinephrine, serotonin, and dopamine, produces aggressive phenotypes across species. Norepinephrine 112-126 monoamine oxidase A Homo sapiens 24-43 18463263-1 2008 The genetic deletion of monoamine oxidase A (MAO A), an enzyme that breaks down the monoamine neurotransmitters norepinephrine, serotonin, and dopamine, produces aggressive phenotypes across species. Norepinephrine 112-126 monoamine oxidase A Homo sapiens 45-50 18177483-0 2008 Chronic noradrenaline increases renal expression of NHE-3, NBC-1, BSC-1 and aquaporin-2. Norepinephrine 8-21 aquaporin 2 Rattus norvegicus 76-87 18177483-13 2008 We conclude that noradrenaline-induced increases in the expression of NHE-3, NBC-1, BSC-1 and aquaporin-2 are likely to play an important role in the regulation of salt and water transport by noradrenaline in the kidney and may explain, at least in part, the altered renal sodium and water handling associated with overactivation of the sympathetic system. Norepinephrine 17-30 aquaporin 2 Rattus norvegicus 94-105 18194185-9 2008 In CC strips precontracted with norepinephrine, histamine, and endothelin-1, both ClC blockers significantly reversed the tone. Norepinephrine 32-46 cystic fibrosis transmembrane conductance regulator Oryctolagus cuniculus 82-85 18388730-1 2008 Monoamine oxidase A (MAOA) enzymatically degrades biogenic amines such as norepinephrine, dopamine, and serotonin, and plays a key role in the regulation of their neurotransmission. Norepinephrine 74-88 monoamine oxidase A Homo sapiens 0-19 18388730-1 2008 Monoamine oxidase A (MAOA) enzymatically degrades biogenic amines such as norepinephrine, dopamine, and serotonin, and plays a key role in the regulation of their neurotransmission. Norepinephrine 74-88 monoamine oxidase A Homo sapiens 21-25 18193048-1 2008 Morphine, a powerful analgesic, and norepinephrine, the principal neurotransmitter of sympathetic nerves, exert major inhibitory effects on both peripheral and brain neurons by activating distinct cell-surface G protein-coupled receptors-the mu-opioid receptor (MOR) and alpha2A-adrenergic receptor (alpha2A-AR), respectively. Norepinephrine 36-50 opioid receptor mu 1 Homo sapiens 242-260 18193048-1 2008 Morphine, a powerful analgesic, and norepinephrine, the principal neurotransmitter of sympathetic nerves, exert major inhibitory effects on both peripheral and brain neurons by activating distinct cell-surface G protein-coupled receptors-the mu-opioid receptor (MOR) and alpha2A-adrenergic receptor (alpha2A-AR), respectively. Norepinephrine 36-50 opioid receptor mu 1 Homo sapiens 262-265 18193048-4 2008 We discovered that morphine binding to the MOR triggers a conformational change in the norepinephrine-occupied alpha2A-AR that inhibits its signaling to G(i) and the downstream MAP kinase cascade. Norepinephrine 87-101 opioid receptor mu 1 Homo sapiens 43-46 18063000-9 2008 In conclusion, inhibitory P2Y and facilitatory P2X1-like receptors, involved in the regulation of glutamate (P2Y13 and/or P2Y1) and noradrenaline (P2Y13 and/or P2Y1, P2Y12) release have been identified, which provide novel target sites for analgesics acting at the spinal cord level. Norepinephrine 132-145 purinergic receptor P2Y12 Rattus norvegicus 166-171 18312831-1 2008 INTRODUCTION: The norepinephrine transporter (NET) is located presynaptically on noradrenergic nerve terminals and plays a critical role in the regulation of the synaptic norepinephrine (NE) concentration via the reuptake of NE. Norepinephrine 18-32 solute carrier family 6 member 2 Rattus norvegicus 46-49 18673168-2 2008 As such, modulation of the histamine H(3) receptor is expected to affect wake via control of the release of histamine and to affect cognition via regulation of several other neurotransmitters including acetylcholine and norepinephrine. Norepinephrine 220-234 histamine receptor H3 Homo sapiens 27-50 17884271-5 2008 The present results suggest that high-activity MAO-A genotypes possibly by consecutively decreased serotonin and/or norepinephrine availability negatively influence antidepressant treatment response during the first six weeks of pharmacological treatment in female patients with Major Depression. Norepinephrine 116-130 monoamine oxidase A Homo sapiens 47-52 17951539-1 2007 To examine whether norepinephrine, through activation of alpha1b-adrenergic receptor, regulates male fertility and testicular functions, we used alpha1b-adrenergic receptor knockout (alpha1b-AR-KO) mice. Norepinephrine 19-33 adrenergic receptor, alpha 1b Mus musculus 57-84 17531968-6 2007 To determine whether Hand2 regulates noradrenergic differentiation, the levels of the norepinephrine biosynthetic enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) was examined. Norepinephrine 86-100 heart and neural crest derivatives expressed 2 Mus musculus 21-26 17429057-9 2007 Indeed, K(+)-induced norepinephrine exocytosis from cardiac synaptosomes was potentiated in PAI-1(-/-), attenuated in t-PA(-/-) and not different from WT in u-PA(-/-) and plgn(-/-) mice. Norepinephrine 21-35 serine (or cysteine) peptidase inhibitor, clade E, member 1 Mus musculus 92-97 17417058-1 2007 OBJECTIVE: Monoamine oxidase A is a mitochondrial enzyme involved in the degradation of certain neurotransmitter amines: serotonin and norepinephrine. Norepinephrine 135-149 monoamine oxidase A Homo sapiens 11-30 17725036-2 2007 An immunocytochemical study has been performed of development of neurons producing gonadotropin-releasing hormone (GnRH) under conditions of excess of serotonin and noradrenaline in the mice in embryogenesis. Norepinephrine 165-178 gonadotropin releasing hormone 1 Mus musculus 83-113 17725036-2 2007 An immunocytochemical study has been performed of development of neurons producing gonadotropin-releasing hormone (GnRH) under conditions of excess of serotonin and noradrenaline in the mice in embryogenesis. Norepinephrine 165-178 gonadotropin releasing hormone 1 Mus musculus 115-119 17725036-5 2007 The percent of the GnRH-neurons in the Tg8 mouse embryos in caudal parts of the migration trajectory was lower than in rostral parts, the opposite distribution of the neurons being observed in the C3H line mouse embryos; at the excess of serotonin and noradrenaline in the Tg8 line mouse embryos, the total amount of GnRH-neurons in the brain was lower than in the C3H mice. Norepinephrine 252-265 gonadotropin releasing hormone 1 Mus musculus 19-23 17725036-6 2007 In males of the Tg8 line mice under conditions of excess of serotonin and noradrenaline the optical density of neurons, which correlated with the GnRH concentration in the cell, was higher than in control mice. Norepinephrine 74-87 gonadotropin releasing hormone 1 Mus musculus 146-150 17725036-7 2007 Thus, in the Tg8 mice under conditions of the serotonin and noradrenaline excess, migration of the GnRH-neurons to their final anlage in hypothalamus is accelerated as well as the total number of the GnRH-neurons decreases, which indicates a decrease of proliferation of cells-precursors and the earlier differentiation of neurons. Norepinephrine 60-73 gonadotropin releasing hormone 1 Mus musculus 99-103 17725036-7 2007 Thus, in the Tg8 mice under conditions of the serotonin and noradrenaline excess, migration of the GnRH-neurons to their final anlage in hypothalamus is accelerated as well as the total number of the GnRH-neurons decreases, which indicates a decrease of proliferation of cells-precursors and the earlier differentiation of neurons. Norepinephrine 60-73 gonadotropin releasing hormone 1 Mus musculus 200-204 17287146-1 2007 Limiting dopamine beta-monooxygenase results in lower norepinephrine (NE) and higher dopamine (DA) concentrations in copper-deficient Cu- tissues compared to copper-adequate Cu+ tissues. Norepinephrine 54-68 dopamine beta-hydroxylase Rattus norvegicus 9-36 20409839-7 2007 In vitro studies indicate that renalase is a novel amine oxidase that specifically metabolizes circulating catecholamines including epinephrine and norepinephrine. Norepinephrine 148-162 renalase, FAD dependent amine oxidase Homo sapiens 31-39 17133078-4 2007 These systems allow bacteria to communicate across species boundaries, and the AI-3/epinephrine/norepinephrine system is involved in interkingdom signaling. Norepinephrine 96-110 family with sequence similarity 83 member H Homo sapiens 79-83 16959848-4 2006 The endogenous adrenergic neurotransmitter norepinephrine induced a potent increase in GLUT1 mRNA and a decrease of GLUT4 mRNA in mature brown adipocytes. Norepinephrine 43-57 solute carrier family 2 (facilitated glucose transporter), member 1 Mus musculus 87-92 16959848-8 2006 Norepinephrine treatment led to a large increase of GLUT1 protein amount in brown adipocytes as visualized with immunocytochemical staining and subcellular fractionation. Norepinephrine 0-14 solute carrier family 2 (facilitated glucose transporter), member 1 Mus musculus 52-57 17356229-1 2006 Phenylethanolamine N-methyltransferase (PNMT) is a final enzyme in catecholamine synthesizing cascade that converts noradrenaline to adrenaline. Norepinephrine 116-129 phenylethanolamine-N-methyltransferase Rattus norvegicus 0-38 17356229-1 2006 Phenylethanolamine N-methyltransferase (PNMT) is a final enzyme in catecholamine synthesizing cascade that converts noradrenaline to adrenaline. Norepinephrine 116-129 phenylethanolamine-N-methyltransferase Rattus norvegicus 40-44 17175506-1 2006 Phenylethanolamine N-methyltransferase (PNMT) is the final enzyme in the catecholamine synthesizing cascade that converts noradrenaline (NA) to adrenaline (Adr). Norepinephrine 122-135 phenylethanolamine-N-methyltransferase Rattus norvegicus 0-38 17175506-1 2006 Phenylethanolamine N-methyltransferase (PNMT) is the final enzyme in the catecholamine synthesizing cascade that converts noradrenaline (NA) to adrenaline (Adr). Norepinephrine 122-135 phenylethanolamine-N-methyltransferase Rattus norvegicus 40-44 16893531-2 2006 Because norepinephrine is an important regulator of spontaneous locomotor activity, we speculated that norepinephrine transporter blockade contributes to the effects of some antidepressants on spontaneous locomotor activity. Norepinephrine 8-22 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 103-129 16904088-4 2006 Treatment with EPO significantly reduced apoptosis induced by norepinephrine (NE) in the wild-type cardiomyocytes. Norepinephrine 62-76 erythropoietin Mus musculus 15-18 16814247-1 2006 Noradrenaline signals the initiation of brown fat thermogenesis and the fatty acids liberated by the hormone-stimulated lipolysis act as second messengers to activate the uncoupling protein UCP1. Norepinephrine 0-13 uncoupling protein 1 Homo sapiens 190-194 16735605-1 2006 Nicotine"s modulation of hippocampal noradrenergic neurotransmission may contribute to its mnemonic properties, but the nicotinic acetylcholine receptor (nAChR) subtypes that modulate terminal release of norepinephrine are unknown. Norepinephrine 204-218 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 120-152 16728402-1 2006 Monoamine oxidase (MAO) A is a key enzyme for the degradation of neurotransmitters serotonin, norepinephrine, and dopamine. Norepinephrine 94-108 monoamine oxidase A Homo sapiens 0-25 16762425-2 2006 This review focuses on the molecular function of two major classes of neurotransmitter transporter that are present in the cell membrane of neurons and/or glial cells: the solute carrier (SLC)1 transporter family, which includes the transporters that mediate the Na(+)-dependent uptake of glutamate, and the SLC6 transporter family, which includes the transporters that mediate the Na(+)-dependent uptake of dopamine, 5-HT, norepinephrine, glycine and GABA. Norepinephrine 424-438 melanin concentrating hormone receptor 1 Homo sapiens 172-193 16730340-10 2006 They also suggest that the PDE4D subtype may be of particular importance as an antidepressant target in that it is regulated by repeated treatment with both norepinephrine and serotonin reuptake inhibitors as well as by the PDE4 inhibitor rolipram, drugs that produce antidepressant effects via different neuropharmacological mechanisms. Norepinephrine 157-171 phosphodiesterase 4D, cAMP specific Mus musculus 27-32 16696852-1 2006 Phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28) is the terminal enzyme of the catecholaminergic pathway converting noradrenaline to adrenaline. Norepinephrine 126-139 phenylethanolamine-N-methyltransferase Rattus norvegicus 0-38 16696852-1 2006 Phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28) is the terminal enzyme of the catecholaminergic pathway converting noradrenaline to adrenaline. Norepinephrine 126-139 phenylethanolamine-N-methyltransferase Rattus norvegicus 40-44 16648270-8 2006 The stimulation of I(Ca,L) in response to beta(2)-AR activation was eliminated by disruption of caveolae with 10 mM methyl beta-cyclodextrin or by small interfering RNA directed against caveolin-3, whereas beta(1)-AR stimulation (norepinephrine plus prazosin) of I(Ca,L) was not altered. Norepinephrine 230-244 adrenergic receptor, beta 2 Mus musculus 42-52 16612252-9 2006 By contrast, NPY acted less specifically, blocking norepinephrine release triggered by either nicotine or membrane depolarization. Norepinephrine 51-65 neuropeptide Y Homo sapiens 13-16 16580377-14 2006 CONCLUSION(S): This study demonstrated that ATP is a co-transmitter with noradrenaline in the contraction of the human vas deferens predominantly acting through the P2X1 receptor. Norepinephrine 73-86 purinergic receptor P2X 1 Homo sapiens 165-178 16513451-2 2006 ET-1, angiotensin II, and norepinephrine act via G protein-coupled receptors with a possible involvement of the G-protein beta3 subunit (GNB3) C825T polymorphism. Norepinephrine 26-40 G protein subunit beta 3 Homo sapiens 112-127 16513451-2 2006 ET-1, angiotensin II, and norepinephrine act via G protein-coupled receptors with a possible involvement of the G-protein beta3 subunit (GNB3) C825T polymorphism. Norepinephrine 26-40 G protein subunit beta 3 Homo sapiens 137-141 16687308-3 2006 At the beginning of the night, norepinephrine (NE) elicits a rapid and sustained phosphorylation of CREB into pCREB and a transient synthesis of the immediate early gene products c-FOS and c-JUN that peak 3 h after dark onset. Norepinephrine 31-45 cAMP responsive element binding protein 1 Rattus norvegicus 100-104 16687309-2 2006 Studies with proteasome inhibitors, MG132 and clasto-lactacystin beta-lactone (c-lact), show two opposite effects of proteasomal inhibition on norepinephrine (NE)-induction of Aanat. Norepinephrine 143-157 aralkylamine N-acetyltransferase Rattus norvegicus 176-181 17017570-1 2006 In the 1950s it was found that an artificial aminoacid, 3,4-threo-dihydroxyphenylserine (DOPS), was converted to norepinephrine (NE) in a single step by the enzyme L-aromatic amino acid decarboxylase (AADC), bypassing the need for the rate limiting enzyme dopamine beta hydroxylase. Norepinephrine 113-127 dopamine beta-hydroxylase Homo sapiens 256-281 17447416-1 2006 Monoamine oxidases A and B (MAO A and MAO B) are the major enzymes that catalyze the oxidative deamination of monoamine neurotaransmitters such as dopamine (DA), noradrenaline, and serotonin in the central and peripheral nervous systems. Norepinephrine 162-175 monoamine oxidase A Homo sapiens 0-26 17447416-1 2006 Monoamine oxidases A and B (MAO A and MAO B) are the major enzymes that catalyze the oxidative deamination of monoamine neurotaransmitters such as dopamine (DA), noradrenaline, and serotonin in the central and peripheral nervous systems. Norepinephrine 162-175 monoamine oxidase A Homo sapiens 28-43 16354910-0 2005 Mecp2 deficiency disrupts norepinephrine and respiratory systems in mice. Norepinephrine 26-40 methyl CpG binding protein 2 Mus musculus 0-5 16166080-2 2005 Norepinephrine binds to the beta-adrenergic receptor and stimulates an increase in intracellular cAMP levels, leading to the transcriptional activation of serotonin N-acetyltransferase, which in turn promotes melatonin production. Norepinephrine 0-14 aralkylamine N-acetyltransferase Rattus norvegicus 155-184 16171784-0 2005 Norepinephrine but not hypoxia stimulates HIF-1alpha gene expression in brown adipocytes. Norepinephrine 0-14 hypoxia inducible factor 1, alpha subunit Mus musculus 42-52 16171784-2 2005 In the present study, the sympathetically controlled brown adipose tissue was used to investigate the effect of norepinephrine on HIF-1alpha gene expression. Norepinephrine 112-126 hypoxia inducible factor 1, alpha subunit Mus musculus 130-140 16171784-3 2005 Norepinephrine increased HIF-1alpha mRNA levels in cultured brown adipocytes, whereas the hypoxia-mimic cobalt was without effect. Norepinephrine 0-14 hypoxia inducible factor 1, alpha subunit Mus musculus 25-35 16171784-6 2005 These results demonstrate that cold-induced HIF-1alpha gene expression is independent of thermogenic oxygen consumption leading to hypoxia, but is consistent with a norepinephrine regulation of HIF-1alpha gene expression. Norepinephrine 165-179 hypoxia inducible factor 1, alpha subunit Mus musculus 194-204 16171784-7 2005 Thus, by elevating HIF-1alpha gene expression, norepinephrine may mediate an increased potential to respond to hypoxia in brown adipose tissue and possibly in other tissues. Norepinephrine 47-61 hypoxia inducible factor 1, alpha subunit Mus musculus 19-29 15975715-2 2005 After 14 postnatal days, concentrations of biogenic amines were smaller in mecp2-null mice than those in control mice and at 42 postnatal days, norepinephrine, dopamine and serotonin concentrations in mecp2-null mice were significantly smaller by 25, 24 and 16%, respectively. Norepinephrine 144-158 methyl CpG binding protein 2 Mus musculus 201-206 15850450-1 2005 BACKGROUND INFORMATION: NPY (neuropeptide Y) may have an effect on the properties of vascular endothelial cells such as pro-angiogenic effects and potentiation of noradrenaline-induced vasoconstriction. Norepinephrine 163-176 neuropeptide Y Homo sapiens 24-27 15850450-1 2005 BACKGROUND INFORMATION: NPY (neuropeptide Y) may have an effect on the properties of vascular endothelial cells such as pro-angiogenic effects and potentiation of noradrenaline-induced vasoconstriction. Norepinephrine 163-176 neuropeptide Y Homo sapiens 29-43 15661972-7 2005 Urinary norepinephrine excretion was higher in RGS2-/-than in RGS2+/+mice. Norepinephrine 8-22 regulator of G-protein signaling 2 Mus musculus 47-51 15661972-7 2005 Urinary norepinephrine excretion was higher in RGS2-/-than in RGS2+/+mice. Norepinephrine 8-22 regulator of G-protein signaling 2 Mus musculus 62-66 15841207-5 2005 Here we report the identification of a novel flavin adenine dinucleotide-dependent amine oxidase (renalase) that is secreted into the blood by the kidney and metabolizes catecholamines in vitro (renalase metabolizes dopamine most efficiently, followed by epinephrine, and then norepinephrine). Norepinephrine 277-291 renalase, FAD dependent amine oxidase Homo sapiens 98-106 15841207-5 2005 Here we report the identification of a novel flavin adenine dinucleotide-dependent amine oxidase (renalase) that is secreted into the blood by the kidney and metabolizes catecholamines in vitro (renalase metabolizes dopamine most efficiently, followed by epinephrine, and then norepinephrine). Norepinephrine 277-291 renalase, FAD dependent amine oxidase Homo sapiens 195-203 15647328-0 2005 Ectonucleoside triphosphate diphosphohydrolase 1/CD39, localized in neurons of human and porcine heart, modulates ATP-induced norepinephrine exocytosis. Norepinephrine 126-140 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 0-48 15647328-0 2005 Ectonucleoside triphosphate diphosphohydrolase 1/CD39, localized in neurons of human and porcine heart, modulates ATP-induced norepinephrine exocytosis. Norepinephrine 126-140 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 49-53 15647328-1 2005 Using a guinea pig heart synaptosomal preparation, we previously observed that norepinephrine (NE) exocytosis was attenuated by a blockade of P2X purinoceptors, potentiated by inhibition of ectonucleoside triphosphate diphosphohydrolase-1 (E-NTPDase1)/CD39, and reduced by soluble CD39, a recombinant form of human E-NTPDase1/CD39. Norepinephrine 79-93 ectonucleoside triphosphate diphosphohydrolase 1 Cavia porcellus 190-238 15647328-1 2005 Using a guinea pig heart synaptosomal preparation, we previously observed that norepinephrine (NE) exocytosis was attenuated by a blockade of P2X purinoceptors, potentiated by inhibition of ectonucleoside triphosphate diphosphohydrolase-1 (E-NTPDase1)/CD39, and reduced by soluble CD39, a recombinant form of human E-NTPDase1/CD39. Norepinephrine 79-93 ectonucleoside triphosphate diphosphohydrolase 1 Cavia porcellus 240-250 15647328-1 2005 Using a guinea pig heart synaptosomal preparation, we previously observed that norepinephrine (NE) exocytosis was attenuated by a blockade of P2X purinoceptors, potentiated by inhibition of ectonucleoside triphosphate diphosphohydrolase-1 (E-NTPDase1)/CD39, and reduced by soluble CD39, a recombinant form of human E-NTPDase1/CD39. Norepinephrine 79-93 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 252-256 15671203-4 2005 MAO-A activity was estimated by measuring concentrations of 3,4-dihydroxyphenylglycol (DHPG), a stable metabolite of norepinephrine. Norepinephrine 117-131 monoamine oxidase A Homo sapiens 0-5 15930502-5 2005 In mice lacking norepinephrine and epinephrine, many of these regions exhibited significantly reduced activation (e.g., hippocampal CA1), while other regions did not (e.g., hippocampal CA3). Norepinephrine 16-30 carbonic anhydrase 1 Mus musculus 132-135 14598308-0 2003 Centrally administered norepinephrine modifies the behavior induced by corticotropin-releasing factor in neonatal chicks. Norepinephrine 23-37 corticotropin releasing hormone Homo sapiens 71-101 14598308-1 2003 We previously reported that glucagon-like peptide-1 decreased corticotropin-releasing factor (CRF)-induced behaviors in neonatal chicks, and such an effect is hypothesized to act through norepinephrine (NE). Norepinephrine 187-201 corticotropin releasing hormone Homo sapiens 62-92 14678242-17 2003 Lipoxygenase products may blunt noradrenaline-induced vasoconstriction, but our observations may, instead, reflect LOX-independent effects of esculetin. Norepinephrine 32-45 polyunsaturated fatty acid lipoxygenase ALOX15 Oryctolagus cuniculus 0-12 12900412-9 2003 The cDNAs tomTHT1-3, tomTHT7-1, and tomTHT7-8 encoded proteins with a high degree of amino acid sequence homology, although the recombinant proteins had different preferences for octopamine and noradrenaline. Norepinephrine 194-207 N-hydroxycinnamoyl-CoA:tyramine N-hydroxycinnamoyl transferase THT7-1 Solanum lycopersicum 21-30 12842874-4 2003 DBH catalyzes norepinephrine synthesis, and several studies have suggested a role for norepinephrine in ethanol-mediated behaviors. Norepinephrine 14-28 dopamine beta-hydroxylase Homo sapiens 0-3 14512028-2 2003 Dopamine-beta-hydroxylase (DBH) is the penultimate enzyme required for synthesis of norepinephrine and is thus a noradrenergic cell type-specific marker. Norepinephrine 84-98 dopamine beta-hydroxylase Homo sapiens 0-25 14512028-2 2003 Dopamine-beta-hydroxylase (DBH) is the penultimate enzyme required for synthesis of norepinephrine and is thus a noradrenergic cell type-specific marker. Norepinephrine 84-98 dopamine beta-hydroxylase Homo sapiens 27-30 14514739-4 2003 Univariate analysis revealed that plasma NPY was directly related to plasma norepinephrine (r = 0.37, P < 0.001) and epinephrine (r = 0.17, P = 0.005), exceeding the upper limit of the normal range in the majority of patients with end-stage renal disease (170 of 277, 61%). Norepinephrine 76-90 neuropeptide Y Homo sapiens 41-44 14514739-7 2003 Plasma NPY maintained its predictive power for CV events in statistical model including plasma norepinephrine. Norepinephrine 95-109 neuropeptide Y Homo sapiens 7-10 12969236-1 2003 This study evaluated the influence of monoamines, serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline, on differentiating gonadotropin-releasing hormone (GnRH)-producing neurones in foetal mice. Norepinephrine 92-105 gonadotropin releasing hormone 1 Mus musculus 158-162 12969236-7 2003 These data suggest that an excess of 5-HT and noradrenaline served to accelerate the GnRH neurone migration in Tg8 mice. Norepinephrine 46-59 gonadotropin releasing hormone 1 Mus musculus 85-89 12969236-8 2003 Moreover, an excess of 5-HT and noradrenaline provided a minor effect on the area and optical density of GnRH neurones (i.e. on GnRH neurone differentiation). Norepinephrine 32-45 gonadotropin releasing hormone 1 Mus musculus 105-109 12969236-8 2003 Moreover, an excess of 5-HT and noradrenaline provided a minor effect on the area and optical density of GnRH neurones (i.e. on GnRH neurone differentiation). Norepinephrine 32-45 gonadotropin releasing hormone 1 Mus musculus 128-132 12969236-9 2003 Thus, an excess of 5-HT and noradrenaline appears to inhibit the proliferation of the precursor cells of GnRH neurones and stimulates the GnRH neurone migration to the place of their final location in the septo-preoptic region. Norepinephrine 28-41 gonadotropin releasing hormone 1 Mus musculus 105-109 12969236-9 2003 Thus, an excess of 5-HT and noradrenaline appears to inhibit the proliferation of the precursor cells of GnRH neurones and stimulates the GnRH neurone migration to the place of their final location in the septo-preoptic region. Norepinephrine 28-41 gonadotropin releasing hormone 1 Mus musculus 138-142 12967948-11 2003 (6) These data suggested (1) a role for the 5-lipoxygenase pathway in the regulation of blood pressure in l-NAME-treated rats and (2) the involvement of endothelial CysLTs in noradrenaline-induced contraction in aorta from l-NAME-treated rats. Norepinephrine 175-188 arachidonate 5-lipoxygenase Rattus norvegicus 44-58 12871653-2 2003 The memory enhancing action of noradrenaline injected into the basal ganglia (lobus parolfactorius-LPO) was reduced in the presence of the alpha(2)-adrenoceptor antagonist yohimbine, but when noradrenaline was injected into the multi-modal association area (intermediate medial hyperstriatum ventrale-IMHV), yohimbine failed to prevent memory enhancement. Norepinephrine 31-44 lactoperoxidase Gallus gallus 99-102 12871653-2 2003 The memory enhancing action of noradrenaline injected into the basal ganglia (lobus parolfactorius-LPO) was reduced in the presence of the alpha(2)-adrenoceptor antagonist yohimbine, but when noradrenaline was injected into the multi-modal association area (intermediate medial hyperstriatum ventrale-IMHV), yohimbine failed to prevent memory enhancement. Norepinephrine 192-205 lactoperoxidase Gallus gallus 99-102 12960750-2 2003 Dopamine beta-hydroxylase catalyses the conversion of dopamine to norepinephrine in noradrenergic cells. Norepinephrine 66-80 dopamine beta-hydroxylase Homo sapiens 0-25 12904944-1 2003 A method to measure catechol- O-methyltransferase (COMT) activity using high performance liquid chromatography-fluorescence detection with norepinephrine (NE) as a natural substrate was optimized for both soluble (S-) and membrane-bound (MB-) COMT activities in rat brain areas, cerebral cortex, cerebellum, hippocampus, brain stem, hypophysis, and hypothalamus. Norepinephrine 139-153 catechol-O-methyltransferase Rattus norvegicus 20-49 12904944-1 2003 A method to measure catechol- O-methyltransferase (COMT) activity using high performance liquid chromatography-fluorescence detection with norepinephrine (NE) as a natural substrate was optimized for both soluble (S-) and membrane-bound (MB-) COMT activities in rat brain areas, cerebral cortex, cerebellum, hippocampus, brain stem, hypophysis, and hypothalamus. Norepinephrine 139-153 catechol-O-methyltransferase Rattus norvegicus 51-55 12847066-1 2003 BACKGROUND: This study tested the hypothesis that beta1-adrenoreceptor blockade modulates the angiotensin II (Ang II)-evoked neural release of norepinephrine (NE) and epinephrine (Epi) into the cardiac interstitial fluid (ISF) space in experimentally induced mitral regurgitation (MR) in the dog. Norepinephrine 143-157 adrenoceptor beta 1 Canis lupus familiaris 50-70 12847066-1 2003 BACKGROUND: This study tested the hypothesis that beta1-adrenoreceptor blockade modulates the angiotensin II (Ang II)-evoked neural release of norepinephrine (NE) and epinephrine (Epi) into the cardiac interstitial fluid (ISF) space in experimentally induced mitral regurgitation (MR) in the dog. Norepinephrine 143-157 ANG Canis lupus familiaris 110-113 12810089-1 2003 We had previously reported that activation of histamine H(3)-receptors (H(3)R) on cardiac adrenergic nerve terminals decreases norepinephrine (NE) overflow from ischemic hearts and alleviates reperfusion arrhythmias. Norepinephrine 127-141 histamine receptor H3 Mus musculus 72-77 12771046-7 2003 In the kidney, the catechol-O-methyltransferase inhibitor quercetin and norepinephrine (10 micromol/L) reduced methylation of 2-hydroxyestradiol by approximately 90% and 41%, respectively. Norepinephrine 72-86 catechol-O-methyltransferase Rattus norvegicus 19-47 12865408-6 2003 VDU1, but not VDU2, is markedly increased in brown adipocytes by norepinephrine or cold exposure, further amplifying the increase in D2 activity that results from catecholamine-stimulated de novo synthesis. Norepinephrine 65-79 ubiquitin specific peptidase 33 Homo sapiens 0-4 12818698-2 2003 In the current study, we examined the role of protein kinase A, protein kinase C and Ca(2+) entry through L-type Ca(2+) channels in naloxone-precipitated increase turnover of noradrenaline in the right and left ventricle. Norepinephrine 175-188 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 46-62 12818698-6 2003 Taken together, these data might indicate that protein kinase A activity is necessary for the enhancement of noradrenaline turnover during morphine withdrawal and that an up-regulated Ca(2+) system might contribute to the increase of noradrenaline turnover. Norepinephrine 109-122 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 47-63 12774312-1 2003 Previously we reported that the synthesis of catecholamines, dopamine, and noradrenaline was enhanced by overexpression of V-1 protein, a neuronal protein active in the initial stage of development of the rat cerebellum, in the neuronal cell line PC12D, a model of dopamine cells (Yamakuni et al. Norepinephrine 75-88 myotrophin Rattus norvegicus 123-134 12736183-1 2003 The effect of cold exposure (4 degrees C) or prolonged norepinephrine infusion on the activity and mRNA levels of glycerokinase (GyK) was investigated in rat interscapular brown adipose tissue (BAT). Norepinephrine 55-69 glycerol kinase Rattus norvegicus 114-127 12736183-1 2003 The effect of cold exposure (4 degrees C) or prolonged norepinephrine infusion on the activity and mRNA levels of glycerokinase (GyK) was investigated in rat interscapular brown adipose tissue (BAT). Norepinephrine 55-69 glycerol kinase Rattus norvegicus 129-132 12802890-4 2003 Correlations among dopamine-beta-hydroxylase measures and behavior reinforced these tonic norepinephrine/behavior associations. Norepinephrine 90-104 dopamine beta-hydroxylase Rattus norvegicus 19-44 12754374-4 2003 Acute administration of adrenaline or noradrenaline increased mPer1 but not mPer2 expression in the liver of mice in vivo and in hepatic slices in vitro. Norepinephrine 38-51 period circadian clock 1 Mus musculus 62-67 12729908-3 2003 We found that noradrenaline transiently induced the expression of mPer1, mPer2, and mE4bp4 1-2 h after alpha(1)-receptor activation. Norepinephrine 14-27 period circadian clock 1 Mus musculus 66-71 12609984-4 2003 We used sympathetic neurons and SK-N-BE(2)M17 neuroblastoma cells to investigate CDF down-regulation of the norepinephrine synthetic enzyme dopamine-beta-hydroxylase (DBH). Norepinephrine 108-122 dopamine beta-hydroxylase Homo sapiens 140-165 12609984-4 2003 We used sympathetic neurons and SK-N-BE(2)M17 neuroblastoma cells to investigate CDF down-regulation of the norepinephrine synthetic enzyme dopamine-beta-hydroxylase (DBH). Norepinephrine 108-122 dopamine beta-hydroxylase Homo sapiens 167-170 12668587-4 2003 Renal norepinephrine spillover was correlated with plasma leptin (r=0.628, P<0.01), but other measures of sympathoadrenal function did not. Norepinephrine 6-20 leptin Homo sapiens 58-64 12694379-14 2003 Our laboratory and others have previously reported that NO increased hypothalamic noradrenaline levels, while conversely noradrenaline up-regulated levels of NO synthase, the enzyme responsible for NO formation; and that injection of corticotropin-releasing factor into the brain ventricles releases catecholamines and stimulates NO formation. Norepinephrine 82-95 corticotropin releasing hormone Homo sapiens 234-264 12694379-14 2003 Our laboratory and others have previously reported that NO increased hypothalamic noradrenaline levels, while conversely noradrenaline up-regulated levels of NO synthase, the enzyme responsible for NO formation; and that injection of corticotropin-releasing factor into the brain ventricles releases catecholamines and stimulates NO formation. Norepinephrine 121-134 corticotropin releasing hormone Homo sapiens 234-264 12651915-3 2003 In endothelium-intact strips, the AT1R-blocker olmesartan (1 microM) and the ACE-inhibitor temocaprilat (1 microM) each enhanced the ACh (0.03 microM)-induced relaxation during the contraction induced by noradrenaline (NA, 10 microM). Norepinephrine 204-217 angiotensin-converting enzyme Oryctolagus cuniculus 77-80 12679149-4 2003 In vessels from NOS-3 knockout mice, noradrenaline contractions consisted of an early steeply rising phase with a later shallow rising phase to a maximum (10.21+/-0.84 mN), which was significantly greater than in wild-type and NOS-2 knockout mice, and resembled the contraction to phenylephrine (10 microM) in wild-type. Norepinephrine 37-50 nitric oxide synthase 3, endothelial cell Mus musculus 16-21 12679149-8 2003 Contractions to noradrenaline in mouse aorta are modulated by NOS-3 and part of the effect involves activation of alpha(2A/D)-adrenoceptors. Norepinephrine 16-29 nitric oxide synthase 3, endothelial cell Mus musculus 62-67 12641739-1 2003 The rat pineal gland is a suitable model to investigate neurotransmitter-controlled gene expression, because it is well established that the stimulation of melatonin biosynthesis by norepinephrine (NE) depends on the activation of the gene that encodes arylalkylamine N-acetyltransferase (AANAT), the melatonin rhythm enzyme. Norepinephrine 182-196 aralkylamine N-acetyltransferase Rattus norvegicus 253-287 12641739-1 2003 The rat pineal gland is a suitable model to investigate neurotransmitter-controlled gene expression, because it is well established that the stimulation of melatonin biosynthesis by norepinephrine (NE) depends on the activation of the gene that encodes arylalkylamine N-acetyltransferase (AANAT), the melatonin rhythm enzyme. Norepinephrine 182-196 aralkylamine N-acetyltransferase Rattus norvegicus 289-294 12660805-7 2003 These findings reveal that CRH-IR levels are specifically increased in norepinephrine- and serotonin-containing pontine nuclei of depressed suicide men, and thus they are consistent with the hypothesis that CRH neurotransmission is elevated in extra-hypothalamic brain regions of depressed subjects. Norepinephrine 71-85 corticotropin releasing hormone Homo sapiens 27-30 12660805-7 2003 These findings reveal that CRH-IR levels are specifically increased in norepinephrine- and serotonin-containing pontine nuclei of depressed suicide men, and thus they are consistent with the hypothesis that CRH neurotransmission is elevated in extra-hypothalamic brain regions of depressed subjects. Norepinephrine 71-85 corticotropin releasing hormone Homo sapiens 207-210 12388442-0 2003 Role of nitric oxide and cyclooxygenase-2 in regulating the renal hemodynamic response to norepinephrine. Norepinephrine 90-104 prostaglandin-endoperoxide synthase 2 Canis lupus familiaris 25-41 12388442-1 2003 We have reported that the renal hemodynamic effects of norepinephrine (NE) are modulated by cyclooxygenase-2 (COX-2)-derived metabolites. Norepinephrine 55-69 prostaglandin-endoperoxide synthase 2 Canis lupus familiaris 92-108 12388442-1 2003 We have reported that the renal hemodynamic effects of norepinephrine (NE) are modulated by cyclooxygenase-2 (COX-2)-derived metabolites. Norepinephrine 55-69 prostaglandin-endoperoxide synthase 2 Canis lupus familiaris 110-115 12615050-1 2003 The beta-2-adrenergic receptor (beta(2)AR) is expressed by most lymphocyte populations and binds the sympathetic neurotransmitter norepinephrine (NE). Norepinephrine 130-144 adrenergic receptor, beta 2 Mus musculus 4-30 12615050-1 2003 The beta-2-adrenergic receptor (beta(2)AR) is expressed by most lymphocyte populations and binds the sympathetic neurotransmitter norepinephrine (NE). Norepinephrine 130-144 adrenergic receptor, beta 2 Mus musculus 32-41 12606256-3 2003 In reserpine-treated rats (97% decrease in endogenous norepinephrine content of the heart), the amplitude of the transient outward current was decreased by 48% and Kv4.2 and Kv4.3 mRNA levels were decreased by 57% and 34%, respectively. Norepinephrine 54-68 potassium voltage-gated channel subfamily D member 2 Rattus norvegicus 164-169 15166499-0 2003 Norepinephrine upregulates vascular endothelial growth factor in rat cardiac myocytes by a paracrine mechanism. Norepinephrine 0-14 vascular endothelial growth factor A Rattus norvegicus 27-61 15166499-2 2003 The present study in cultured neonatal rat cardiac myocytes tested the hypothesis that norepinephrine also stimulates expression of vascular endothelial growth factor (VEGF), an important angiogenic factor. Norepinephrine 87-101 vascular endothelial growth factor A Rattus norvegicus 132-166 15166499-2 2003 The present study in cultured neonatal rat cardiac myocytes tested the hypothesis that norepinephrine also stimulates expression of vascular endothelial growth factor (VEGF), an important angiogenic factor. Norepinephrine 87-101 vascular endothelial growth factor A Rattus norvegicus 168-172 15166499-4 2003 When cardiac myocytes were stimulated with 1 micro M norepinephrine for 24 h in the presence or absence of the specific alpha - and beta -adrenoceptor antagonists prazosin and propranolol, respectively, VEGF mRNA levels and splice variant pattern did not change, whereas atrial natriuretic peptide mRNA levels increased 3 to 4-fold. Norepinephrine 53-67 vascular endothelial growth factor A Rattus norvegicus 203-207 15166499-6 2003 When cardiac myocytes were cultured with conditioned medium from non-myocytes that had been stimulated with norepinephrine for 24 h VEGF mRNA increased 2-fold. Norepinephrine 108-122 vascular endothelial growth factor A Rattus norvegicus 132-136 12522077-0 2003 Pharmacological profiles of presynaptic nociceptin/orphanin FQ receptors modulating 5-hydroxytryptamine and noradrenaline release in the rat neocortex. Norepinephrine 108-121 prepronociceptin Rattus norvegicus 40-50 12522077-0 2003 Pharmacological profiles of presynaptic nociceptin/orphanin FQ receptors modulating 5-hydroxytryptamine and noradrenaline release in the rat neocortex. Norepinephrine 108-121 prepronociceptin Rattus norvegicus 51-62 12522077-1 2003 1 The pharmacological profiles of presynaptic nociceptin/orphanin FQ (N/OFQ) peptide receptors (NOP) modulating 5-hydroxytryptamine (5-HT) and noradrenaline (NE) release in the rat neocortex were characterized in a preparation of superfused synaptosomes challenged with 10 mM KCl. Norepinephrine 143-156 prepronociceptin Rattus norvegicus 46-56 12522077-1 2003 1 The pharmacological profiles of presynaptic nociceptin/orphanin FQ (N/OFQ) peptide receptors (NOP) modulating 5-hydroxytryptamine (5-HT) and noradrenaline (NE) release in the rat neocortex were characterized in a preparation of superfused synaptosomes challenged with 10 mM KCl. Norepinephrine 143-156 prepronociceptin Rattus norvegicus 57-68 12488332-0 2003 Immunolesion of norepinephrine and epinephrine afferents to medial hypothalamus alters basal and 2-deoxy-D-glucose-induced neuropeptide Y and agouti gene-related protein messenger ribonucleic acid expression in the arcuate nucleus. Norepinephrine 16-30 neuropeptide Y Homo sapiens 123-137 12535931-11 2003 Taken together, the data indicate that GTP cyclohydrolase I plays a crucial role in regulating norepinephrine biosynthesis by a pathway the activity of which is triggered by lipopolysaccharide i.p. Norepinephrine 95-109 GTP cyclohydrolase 1 Mus musculus 39-59 12488060-2 2002 Dopamine-beta-hydroxylase (DbetaH) converts dopamine to norepinephrine. Norepinephrine 56-70 dopamine beta-hydroxylase Homo sapiens 0-25 12488060-2 2002 Dopamine-beta-hydroxylase (DbetaH) converts dopamine to norepinephrine. Norepinephrine 56-70 dopamine beta-hydroxylase Homo sapiens 27-33 12474218-1 2002 We have previously reported a highly sensitive method for the measurement of catechol-O-methyltransferase (COMT) activities in rat erythrocytes with norepinephrine (NE), an endogenous native substrate, using high-performance liquid chromatography (HPLC)-fluorescence or peroxyoxalate chemiluminescence reaction detection. Norepinephrine 149-163 catechol-O-methyltransferase Rattus norvegicus 77-105 12474218-1 2002 We have previously reported a highly sensitive method for the measurement of catechol-O-methyltransferase (COMT) activities in rat erythrocytes with norepinephrine (NE), an endogenous native substrate, using high-performance liquid chromatography (HPLC)-fluorescence or peroxyoxalate chemiluminescence reaction detection. Norepinephrine 149-163 catechol-O-methyltransferase Rattus norvegicus 107-111 12457232-1 2002 The rat pineal organ is an established model to study signal transduction cascades that are activated by norepinephrine (NE) and cause increases in cAMP levels and stimulation of protein kinase A (PKA). Norepinephrine 105-119 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 197-200 12444905-1 2002 Neuropeptide Y (NPY) is co-released with noradrenaline from sympathetic nerves, has a strong vasoconstrictive action, and causes an attenuation of parasympathetic action in animal experiments. Norepinephrine 41-54 neuropeptide Y Homo sapiens 0-14 12444905-1 2002 Neuropeptide Y (NPY) is co-released with noradrenaline from sympathetic nerves, has a strong vasoconstrictive action, and causes an attenuation of parasympathetic action in animal experiments. Norepinephrine 41-54 neuropeptide Y Homo sapiens 16-19 12502025-0 2002 Interleukin 1alpha alters hippocampal serotonin and norepinephrine release during open-field behavior in Sprague-Dawley animals: differences from the Fawn-Hooded animal model of depression. Norepinephrine 52-66 interleukin 1 alpha Homo sapiens 0-18 12882365-8 2002 The most prominent neurochemical alterations in the forebrains of aged eNOS-/- mice were: (a) increased acetylcholine levels in the neostriatum; (b) decreased noradrenaline concentrations in the ventral striatum; and (c) lower serotonin levels in the frontal cortex and ventral striatum. Norepinephrine 159-172 nitric oxide synthase 3, endothelial cell Mus musculus 71-75 12375271-4 2002 It has recently been demonstrated that the beta(3)-adrenergic receptor is the functionally relevant adrenergic receptor subtype in brown adipocytes and that its stimulation by noradrenaline (NA) modulates the expression of genes, such as uncoupling protein (UCP)-1 and inducible nitric oxide synthase (iNOS), involved in fat cell proliferation and differentiation. Norepinephrine 176-189 adrenoceptor beta 3 Homo sapiens 43-70 12375271-4 2002 It has recently been demonstrated that the beta(3)-adrenergic receptor is the functionally relevant adrenergic receptor subtype in brown adipocytes and that its stimulation by noradrenaline (NA) modulates the expression of genes, such as uncoupling protein (UCP)-1 and inducible nitric oxide synthase (iNOS), involved in fat cell proliferation and differentiation. Norepinephrine 176-189 uncoupling protein 1 Homo sapiens 238-264 12438093-1 2002 Phenylethanolamine N-methyltransferase (PNMT) methylates norepinephrine (NE) to form epinephrine (E). Norepinephrine 57-71 phenylethanolamine-N-methyltransferase Rattus norvegicus 0-38 12438093-1 2002 Phenylethanolamine N-methyltransferase (PNMT) methylates norepinephrine (NE) to form epinephrine (E). Norepinephrine 57-71 phenylethanolamine-N-methyltransferase Rattus norvegicus 40-44 12242714-1 2002 There are three subtypes of alpha2 adrenoceptor, i.e., alpha2A, alpha2B, and alpha2C, mediating the specific effect of epinephrine and norepinephrine in various tissues by means of G protein-coupled signal transduction pathways. Norepinephrine 135-149 adrenergic receptor, alpha 2b Mus musculus 64-71 12163351-0 2002 Direct and indirect inhibition by nociceptin/orphanin FQ on noradrenaline release from rodent cerebral cortex in vitro. Norepinephrine 60-73 prepronociceptin Rattus norvegicus 34-44 12163351-0 2002 Direct and indirect inhibition by nociceptin/orphanin FQ on noradrenaline release from rodent cerebral cortex in vitro. Norepinephrine 60-73 prepronociceptin Rattus norvegicus 45-56 12163351-1 2002 1 The modulation exerted by nociceptin/orphanin FQ (NC) on noradrenaline (NE) release in rodent cerebral cortex slices and synaptosomes was studied. Norepinephrine 59-72 prepronociceptin Rattus norvegicus 28-38 12163351-1 2002 1 The modulation exerted by nociceptin/orphanin FQ (NC) on noradrenaline (NE) release in rodent cerebral cortex slices and synaptosomes was studied. Norepinephrine 59-72 prepronociceptin Rattus norvegicus 39-50 12091475-1 2002 The antidepressant desipramine (DMI) is a selective inhibitor of norepinephrine (NE) transport that down-regulates the norepinephrine transporter (NET) protein in a concentration- and time-dependent manner in vitro. Norepinephrine 65-79 solute carrier family 6 member 2 Rattus norvegicus 119-145 12091475-1 2002 The antidepressant desipramine (DMI) is a selective inhibitor of norepinephrine (NE) transport that down-regulates the norepinephrine transporter (NET) protein in a concentration- and time-dependent manner in vitro. Norepinephrine 65-79 solute carrier family 6 member 2 Rattus norvegicus 147-150 12106798-3 2002 The possible actions of neuropeptide Y, that is co-localized and released with noradrenaline, as a sympathetic co-transmitter has attracted much attention during the last decade. Norepinephrine 79-92 neuropeptide Y Homo sapiens 24-38 12575297-1 2002 OBJECTIVE: To explore the interaction of low-dosage aspirin combined with angiotensin-converting enzyme (ACE) inhibitors by prostacyclin (PGI2), thromboxone A2 (TXA2) and norepinephrine (NE)) levels in rabbits" blood. Norepinephrine 171-185 angiotensin-converting enzyme Oryctolagus cuniculus 105-108 12010762-6 2002 Hence, on the one hand, trans-10, cis-12 inhibited uncoupling protein (UCP) 1 induction by norepinephrine (NE) and produced a decrease in leptin mRNA levels. Norepinephrine 91-105 uncoupling protein 1 Homo sapiens 51-77 12056558-5 2002 Substance P and NK1 receptors are also intimately associated with ascending 5-HT and norepinephrine projections to the forebrain, and alterations in the function of these systems are also likely to be related to the antidepressant efficacy of SPAs. Norepinephrine 85-99 tachykinin 1 Mus musculus 0-11 12056558-5 2002 Substance P and NK1 receptors are also intimately associated with ascending 5-HT and norepinephrine projections to the forebrain, and alterations in the function of these systems are also likely to be related to the antidepressant efficacy of SPAs. Norepinephrine 85-99 tachykinin 1 Mus musculus 16-19 11956964-5 2002 The homozygous Ala280Val variation in the third intracellular loop of the histamine H(3) receptor of a patient with Shy-Drager syndrome may be related to the etiology of the illness due to altered norepinephrine release. Norepinephrine 197-211 histamine receptor H3 Homo sapiens 74-97 11867178-5 2002 NPY levels correlated inversely with renal plasma flow and glomerular filtration rate and directly with norepinephrine. Norepinephrine 104-118 neuropeptide Y Homo sapiens 0-3 11882635-1 2002 We have reported that norepinephrine (NE) and angiotensin II (Ang II) increase CaM kinase II activity, which, in turn, activates cytosolic phospholipase A(2) (PLA(2)) and releases arachidonic acid. Norepinephrine 22-36 phospholipase A2 group IB Rattus norvegicus 139-157 11882635-1 2002 We have reported that norepinephrine (NE) and angiotensin II (Ang II) increase CaM kinase II activity, which, in turn, activates cytosolic phospholipase A(2) (PLA(2)) and releases arachidonic acid. Norepinephrine 22-36 phospholipase A2 group IB Rattus norvegicus 159-165 11805341-1 2002 Noradrenaline (NA), a key neurotransmitter of the endogenous pain inhibitory system, acutely inhibits nociceptive transmission (including that mediated by substance P), potentiates opioid analgesia, and underlies part of the antinociceptive effects of the widely prescribed tricyclic antidepressants. Norepinephrine 0-13 tachykinin 1 Mus musculus 155-166 12140786-1 2002 Monoamine oxidase A (MAO A) is located on the X chromosome and metabolizes biogenic amines including dopamine, norepinephrine and serotonin. Norepinephrine 111-125 monoamine oxidase A Homo sapiens 0-19 12140786-1 2002 Monoamine oxidase A (MAO A) is located on the X chromosome and metabolizes biogenic amines including dopamine, norepinephrine and serotonin. Norepinephrine 111-125 monoamine oxidase A Homo sapiens 21-26 11739311-4 2001 METHODS AND RESULTS: In primary cardiac myocytes from neonatal rats, immunohistochemical analyses using a specific monoclonal antibody against LOX-1 demonstrated that LOX-1 expression was markedly induced by stimulation with norepinephrine and endothelin-1. Norepinephrine 225-239 oxidized low density lipoprotein receptor 1 Rattus norvegicus 143-148 11739311-4 2001 METHODS AND RESULTS: In primary cardiac myocytes from neonatal rats, immunohistochemical analyses using a specific monoclonal antibody against LOX-1 demonstrated that LOX-1 expression was markedly induced by stimulation with norepinephrine and endothelin-1. Norepinephrine 225-239 oxidized low density lipoprotein receptor 1 Rattus norvegicus 167-172 11514309-1 2001 Phenylethanolamine N-methyltransferase (PNMT) is the enzyme that synthesizes epinephrine from norepinephrine. Norepinephrine 94-108 phenylethanolamine-N-methyltransferase Rattus norvegicus 0-38 11514309-1 2001 Phenylethanolamine N-methyltransferase (PNMT) is the enzyme that synthesizes epinephrine from norepinephrine. Norepinephrine 94-108 phenylethanolamine-N-methyltransferase Rattus norvegicus 40-44 11532892-3 2001 Noradrenaline dose-dependently stimulates phosphoinositide (PI) breakdown in both immature and mature cultures through the activation of alpha1 receptors. Norepinephrine 0-13 adrenoceptor alpha 1D Homo sapiens 137-143 11504801-0 2001 Alpha(1) and beta(2) adrenoreceptor agonists inhibit pentylenetetrazole-induced seizures in mice lacking norepinephrine. Norepinephrine 105-119 adrenergic receptor, beta 2 Mus musculus 13-35 11677796-2 2001 The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3). Norepinephrine 45-58 adrenergic receptor, alpha 2b Mus musculus 246-254 11677796-2 2001 The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3). Norepinephrine 45-58 hemoglobin, beta adult major chain Mus musculus 292-298 11532994-5 2001 These include, as Fe(II), facilitating the production of dopamine from phenylalanine by tyrosine hydroxylase, and as heme, assisting the recycling of ascorbate by cytochrome b-561 required for the generation of norepinephrine from dopamine by dopamine beta-hydroxylase. Norepinephrine 211-225 cytochrome b-561 Rattus norvegicus 163-179 11465644-1 2001 We performed this study to investigate whether changes in plasma glucose, insulin, and norepinephrine concentrations during an oral glucose tolerance test (OGTT) are associated with changes in plasma leptin levels in normotensive and hypertensive obese women. Norepinephrine 87-101 leptin Homo sapiens 200-206 11465644-4 2001 Area under curve (AUC) for plasma leptin showed a direct correlation with norepinephrine AUC in both NT-Ob (r = 0.73, P = .001) and HT-Ob (r = 0.74, P = .001) group, which was still detectable in multivariate analysis (P = .014 and P = .017, respectively). Norepinephrine 74-88 leptin Homo sapiens 34-40 11465644-5 2001 Our study confirms that glucose loading increases circulating leptin concentrations in obese women, and demonstrates the existance of an association between leptin and norepinephrine changes during OGTT in both normotensive and hypertensive obese women. Norepinephrine 168-182 leptin Homo sapiens 157-163 11239919-0 2001 Inhibition by L-3,4-dihydroxyphenylalanine of hippocampal CA1 neurons with facilitation of noradrenaline and gamma-aminobutyric acid release. Norepinephrine 91-104 carbonic anhydrase 1 Rattus norvegicus 58-61 11310603-2 2001 Metaraminol ((1R,2S)-2-amino-1-(3-hydroxyphenyl)-1-propanol) is a metabolically stable structural analogue of norepinephrine and possesses high affinity towards the norepinephrine transporter and the vesicular monoamine transporter. Norepinephrine 110-124 solute carrier family 6 member 2 Rattus norvegicus 165-191 11285376-10 2001 The CSF metabolite of norepinephrine (MHPG) was lower (P:=0.003) in PFS patients (8.33+/-0.33 ng/ml) than in matched controls (9.89+/-0.31 ng/ml) and 5-HIAA was lower (P=0.042) in PFS female patients (22.34+/-1.78 ng/ml) than in matched controls (25.75+/-1.75 ng/ml). Norepinephrine 22-36 colony stimulating factor 2 Homo sapiens 4-7 11154836-2 2001 These cells express the mRNA encoding estrogen receptor alpha (ERalpha) and respond to physiological concentrations of 17beta-estradiol (E2) by reducing the accumulation of cyclic adenosine monophosphate induced by norepinephrine, but not that induced by direct activation of adenylate cyclase. Norepinephrine 215-229 estrogen receptor 1 (alpha) Mus musculus 38-61 11154836-2 2001 These cells express the mRNA encoding estrogen receptor alpha (ERalpha) and respond to physiological concentrations of 17beta-estradiol (E2) by reducing the accumulation of cyclic adenosine monophosphate induced by norepinephrine, but not that induced by direct activation of adenylate cyclase. Norepinephrine 215-229 estrogen receptor 1 (alpha) Mus musculus 63-70 11258636-3 2001 At the point of exhaustion significantly higher values for norepinephrine and epinephrine were observed in ST2 than in ST1. Norepinephrine 59-73 syndecan binding protein Homo sapiens 119-122 11133901-7 2001 At sea level, plasma norepinephrine levels during exercise were 48% greater when subjects were alpha-blocked compared with their placebo trial. Norepinephrine 21-35 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 3-6 11173978-2 2001 The ADH1 enzymes, the classical liver forms, are involved in several metabolic pathways beside the oxidation of ethanol, e.g. norepinephrine, dopamine, serotonin and bile acid metabolism. Norepinephrine 126-140 alcohol dehydrogenase 1A (class I), alpha polypeptide Homo sapiens 4-8 11179598-3 2001 Blockade of CRH receptors with alphah-CRF (10 microg) attenuated or blocked the BN-induced rise in plasma ACTH, epinephrine, norepinephrine, glucose and corticosterone levels. Norepinephrine 125-139 corticotropin releasing hormone Homo sapiens 12-15 11100982-2 2000 We previously demonstrated that atrial natriuretic factor and B- and C-type natriuretic peptides (ANF, BNP, and CNP, respectively) modified catecholamine metabolism by increasing the neuronal uptake and decreasing the neuronal release of norepinephrine in the rat hypothalamus. Norepinephrine 238-252 2',3'-cyclic nucleotide 3' phosphodiesterase Rattus norvegicus 112-115 11100982-3 2000 The aim of the present work was to study the effects of natriuretic peptides BNP and CNP on norepinephrine uptake as an index of the amine metabolism in discrete areas and nuclei of the central nervous system (CNS) of the rat. Norepinephrine 92-106 2',3'-cyclic nucleotide 3' phosphodiesterase Rattus norvegicus 85-88 11100982-6 2000 Results showed that 100 nM BNP and 1 nM CNP increased norepinephrine (NE) uptake in all brain areas and nuclei studied. Norepinephrine 54-68 2',3'-cyclic nucleotide 3' phosphodiesterase Rattus norvegicus 40-43 11084220-4 2000 The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA. Norepinephrine 22-35 interleukin 1 receptor antagonist Homo sapiens 175-181 11084220-4 2000 The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA. Norepinephrine 22-35 interleukin 1 receptor antagonist Homo sapiens 351-357 11084220-4 2000 The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA. Norepinephrine 96-109 interleukin 1 receptor antagonist Homo sapiens 175-181 11084220-4 2000 The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA. Norepinephrine 96-109 interleukin 1 receptor antagonist Homo sapiens 351-357 11033344-5 2000 Naloxone and opioid agents, such as morphine, beta-endorphin and [Met(5)]-enkephalin, significantly enhanced and attenuated the stress-induced increase in noradrenaline release in these regions and the stress-induced emotional change, respectively. Norepinephrine 155-168 proenkephalin Rattus norvegicus 74-84 11028916-10 2000 Since PHM is homologous in sequence and mechanism to dopamine beta-monooxygenase (DBM; EC 1.14.17.1), the enzyme that converts dopamine to norepinephrine during catecholamine biosynthesis, these structural and mechanistic insights are extended to DBM. Norepinephrine 139-153 dopamine beta-hydroxylase Rattus norvegicus 53-80 10900181-0 2000 Interactions of dynorphin A-(1-13) and nociceptin with cardiac D2 binding sites: inhibition of ischemia-evoked release of noradrenaline from synaptosomal-mitochondrial fractions. Norepinephrine 122-135 prepronociceptin Rattus norvegicus 39-49 10997600-2 2000 Both serotonin, acting through 5HT1B/2C receptors, and norepinephrine acting through beta2 and/or beta3 receptors reduce food intake and augment sympathetic activity. Norepinephrine 55-69 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 98-103 10997617-5 2000 Activity and expression of the three UCP"s are stimulated by several neuromediators and hormones such as noradrenaline, tri-iodothyronine and leptin. Norepinephrine 105-118 uncoupling protein 1 Homo sapiens 37-40 10835639-0 2000 Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system. Norepinephrine 47-60 GATA binding protein 3 Mus musculus 0-5 10788502-0 2000 Norepinephrine induces vascular endothelial growth factor gene expression in brown adipocytes through a beta -adrenoreceptor/cAMP/protein kinase A pathway involving Src but independently of Erk1/2. Norepinephrine 0-14 Rous sarcoma oncogene Mus musculus 165-168 10769386-1 2000 The action of norepinephrine (NE) is terminated, in part, by its uptake into presynaptic noradrenergic neurons by the plasma-membrane NE transporter (NET), which is a target for antidepressants and psychostimulants. Norepinephrine 14-28 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 134-148 10769386-1 2000 The action of norepinephrine (NE) is terminated, in part, by its uptake into presynaptic noradrenergic neurons by the plasma-membrane NE transporter (NET), which is a target for antidepressants and psychostimulants. Norepinephrine 14-28 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 150-153 10718926-0 2000 Adrenoceptor subtype involvement in suppression of prolactin secretion by noradrenaline. Norepinephrine 74-87 prolactin Ovis aries 51-60 10718926-1 2000 In sheep, injection of noradrenaline suppresses prolactin secretion by a direct effect at the pituitary gland. Norepinephrine 23-36 prolactin Ovis aries 48-57 10718926-2 2000 The aims of this study were to use primary cultures of ovine pituitary cells to examine the receptor subtypes that mediate the inhibitory effect of noradrenaline on prolactin secretion and, by using receptor antagonists in vivo, determine whether noradrenaline acts as a prolactin release-inhibiting factor (PIF). Norepinephrine 148-161 prolactin Ovis aries 165-174 10718926-3 2000 Noradrenaline and dopamine suppressed prolactin secretion from ovine pituitary cells with ED50s of 60.9+/-46.6 and 1.5+/-1.0x10-9 mol/l, respectively (P<0.05). Norepinephrine 0-13 prolactin Ovis aries 38-47 10718926-4 2000 The in-vitro prolactin release-inhibiting effect of noradrenaline (10-7 mol/l) was not blocked by the dopamine antagonists pimozide (D2) or SCH23390 (D1) but was blocked by each of the adrenoceptor antagonists (alpha1-adrenoceptor antagonists prazosin and WB4101, the alpha2-adrenoceptor antagonist yohimbine and the beta-adrenoceptor antagonist propranolol). Norepinephrine 52-65 prolactin Ovis aries 13-22 10715359-2 2000 In turn, neuropeptide Y (NPY) has been shown to inhibit the release of norepinephrine from sympathetic noradrenergic neurons. Norepinephrine 71-85 neuropeptide Y Homo sapiens 9-23 10715359-2 2000 In turn, neuropeptide Y (NPY) has been shown to inhibit the release of norepinephrine from sympathetic noradrenergic neurons. Norepinephrine 71-85 neuropeptide Y Homo sapiens 25-28 10845761-4 2000 All neurogenic constrictor responses are related to the release of norepinephrine from adrenergic nerves that act on post-junctional alpha-1 and pre-junctional and post-junctional alpha-2 receptor subtypes. Norepinephrine 67-81 adrenoceptor alpha 1D Homo sapiens 133-140 10723850-12 2000 Disulfiram inhibits dopamine beta-hydroxylase resulting in an excess of dopamine and decreased synthesis of norepinephrine. Norepinephrine 108-122 dopamine beta-hydroxylase Homo sapiens 20-45 10679505-8 2000 In all cases, the alpha(2)-AR-deficient groups tended to have higher norepinephrine levels than their wild-type counterparts. Norepinephrine 69-83 adrenergic receptor, alpha 2b Mus musculus 18-29 10679505-9 2000 Surprisingly, this difference was significant only in the alpha(2B)-AR-deficient mice, which, despite the elevated norepinephrine, were unable to raise their BP. Norepinephrine 115-129 adrenergic receptor, alpha 2b Mus musculus 58-70 10629750-2 1999 Upon binding of L-glutamate to the class II metabotropic glutamate receptor, norepinephrine (NE)-dependent formation of cAMP was inhibited, resulting in decreased serotonin-N-acetyltransferase (NAT) activity and melatonin output. Norepinephrine 77-91 aralkylamine N-acetyltransferase Rattus norvegicus 163-192 10629750-2 1999 Upon binding of L-glutamate to the class II metabotropic glutamate receptor, norepinephrine (NE)-dependent formation of cAMP was inhibited, resulting in decreased serotonin-N-acetyltransferase (NAT) activity and melatonin output. Norepinephrine 77-91 aralkylamine N-acetyltransferase Rattus norvegicus 194-197 10619567-10 1999 These results show that homozygous BDNF mutations produce severe depletions within the nigrostriatal dopaminergic system and substantial reductions of norepinephrine within the hypothalamus and olfactory bulb. Norepinephrine 151-165 brain derived neurotrophic factor Mus musculus 35-39 10513987-3 1999 The stimulation of PLA2/lysophospholipase activity by noradrenaline (NA) was prevented either by the alpha1-adrenergic antagonist prazosin or arachidonyl trifluoromethyl ketone, a selective inhibitor of the 85-110 kDa, sn-2-arachidonyl-specific cytosolic PLA2. Norepinephrine 54-67 phospholipase A2 group IB Rattus norvegicus 19-23 10513987-3 1999 The stimulation of PLA2/lysophospholipase activity by noradrenaline (NA) was prevented either by the alpha1-adrenergic antagonist prazosin or arachidonyl trifluoromethyl ketone, a selective inhibitor of the 85-110 kDa, sn-2-arachidonyl-specific cytosolic PLA2. Norepinephrine 54-67 phospholipase A2 group IB Rattus norvegicus 255-259 10560019-0 1999 Genetic approaches to studying norepinephrine function: knockout of the mouse norepinephrine transporter gene. Norepinephrine 31-45 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 78-104 10560019-6 1999 For the norepinephrine transporter knockout mice, this altered state of the norepinephrine system should simulate the therapeutic effects of norepinephrine selective antidepressants and some of the effects of psychostimulants. Norepinephrine 76-90 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 8-34 10499537-0 1999 Norepinephrine is required for leptin effects on gene expression in brown and white adipose tissue. Norepinephrine 0-14 leptin Mus musculus 31-37 10499537-11 1999 These studies establish that norepinephrine is required for leptin to regulate its own expression in WAT and UCP1 expression in BAT and indicate that these effects are likely mediated through the centrally expressed long form of the leptin receptor. Norepinephrine 29-43 leptin Mus musculus 60-66 10499537-11 1999 These studies establish that norepinephrine is required for leptin to regulate its own expression in WAT and UCP1 expression in BAT and indicate that these effects are likely mediated through the centrally expressed long form of the leptin receptor. Norepinephrine 29-43 leptin receptor Mus musculus 233-248 10502659-2 1999 Noradrenaline and potassium chloride induced concentration-dependent vasoconstrictions in both vessel types but the basal tension, maximum tension, and the -log concentration producing half-maximal response (pEC50) were altered in the presence of 0.1 or 20 U ml-1 EPO. Norepinephrine 0-13 erythropoietin Rattus norvegicus 264-267 10409268-2 1999 In this study, primary brown adipocyte cultures were used to determine the role of beta-AR subtypes in mediating lipolysis and uncoupling protein-1 (UCP1) gene expression, elicited by the physiological neurohormone norepinephrine (NE). Norepinephrine 215-229 uncoupling protein 1 Homo sapiens 127-153 10375675-1 1999 In the rat pineal gland, norepinephrine activates alpha1- and beta-adrenergic receptors and triggers melatonin production through an increase in the intracellular calcium concentration ([Ca2+]i) and stimulation of the cAMP/cAMP responsive element-binding protein (CREB) cascade. Norepinephrine 25-39 cAMP responsive element binding protein 1 Rattus norvegicus 218-262 10375675-1 1999 In the rat pineal gland, norepinephrine activates alpha1- and beta-adrenergic receptors and triggers melatonin production through an increase in the intracellular calcium concentration ([Ca2+]i) and stimulation of the cAMP/cAMP responsive element-binding protein (CREB) cascade. Norepinephrine 25-39 cAMP responsive element binding protein 1 Rattus norvegicus 264-268 10375675-5 1999 Norepinephrine-regulated calcium signaling and phosphorylation of CREB are already fully developed at birth, i.e., prior to ingrowth of the sympathetic innervation into the pineal parenchyma, and appear to develop in an innervation-independent manner. Norepinephrine 0-14 cAMP responsive element binding protein 1 Rattus norvegicus 66-70 10375680-2 1999 LHRH secretion is probably controlled by prior pulsatile norepinephrine (NE) release. Norepinephrine 57-71 gonadotropin releasing hormone 1 Rattus norvegicus 0-4 10037744-2 1999 NET is expressed only in neuronal tissues that synthesize and secrete norepinephrine and in most cases is co-expressed with the norepinephrine-synthetic enzyme dopamine beta-hydroxylase (DBH). Norepinephrine 128-142 dopamine beta-hydroxylase Homo sapiens 187-190 10205006-0 1999 Adenosine 5"-triphosphate and neuropeptide Y are co-transmitters in conjunction with noradrenaline in the human saphenous vein. Norepinephrine 85-98 neuropeptide Y Homo sapiens 30-44 10535688-6 1999 In contrast, the beta2-adrenoceptor-mediated relaxations of the noradrenaline-constricted pulmonary artery and aorta did not display a significant loss of sensitivity. Norepinephrine 64-77 adrenoceptor beta 2 Rattus norvegicus 17-35 10700334-1 1999 Neuropeptide Y(NPY) co-exists with norepinephrine in the sympathetic nervous system, and NPY may represent the sympathetic-neuronal output. Norepinephrine 35-49 neuropeptide Y Homo sapiens 0-19 10050962-5 1999 When available, plasma samples were evaluated first for levels of 3-methoxy, 4-hydroxyphenolglycol (MHPG), a metabolite of norepinephrine which serves as the most sensitive index of MAO-A activity in humans. Norepinephrine 123-137 monoamine oxidase A Homo sapiens 182-187 10094138-1 1999 The effect of the cholinesterase inhibitor neostigmine on hippocampal noradrenaline (NA) release was studied using in vivo microdialysis. Norepinephrine 70-83 butyrylcholinesterase Homo sapiens 18-32 9928995-4 1999 It is concluded that sympathetic control of VEGF expression via noradrenaline acting on beta3-adrenoceptors plays a major role in developmental and adaptive angiogenesis, and defects in this contribute to the reduced thermogenic capacity of BAT in genetic obesity. Norepinephrine 64-77 vascular endothelial growth factor A Rattus norvegicus 44-48 10027098-0 1999 Histamine H3 receptor-mediated inhibition of noradrenaline release in the human brain. Norepinephrine 45-58 histamine receptor H3 Homo sapiens 0-21 9889075-3 1999 Here we find that 8-Br-cAMP, norepinephrine, or SKF38393 given 3 h posttraining into rat CA1 reverses the amnestic effect of KN-62 given into the amygdala 0 h after training, but not that of KN-62 given into CA1 0 h posttraining. Norepinephrine 29-43 carbonic anhydrase 1 Rattus norvegicus 89-92 9889075-3 1999 Here we find that 8-Br-cAMP, norepinephrine, or SKF38393 given 3 h posttraining into rat CA1 reverses the amnestic effect of KN-62 given into the amygdala 0 h after training, but not that of KN-62 given into CA1 0 h posttraining. Norepinephrine 29-43 carbonic anhydrase 1 Rattus norvegicus 208-211 10465445-5 1999 Local infusion of the acetylcholinesterase inhibitor soman (0.4 mM) into the olfactory bulb increased basal norepinephrine levels by 134% of control, suggesting that endogenously released acetylcholine modulates norepinephrine release. Norepinephrine 108-122 acetylcholinesterase Rattus norvegicus 22-42 10465445-5 1999 Local infusion of the acetylcholinesterase inhibitor soman (0.4 mM) into the olfactory bulb increased basal norepinephrine levels by 134% of control, suggesting that endogenously released acetylcholine modulates norepinephrine release. Norepinephrine 212-226 acetylcholinesterase Rattus norvegicus 22-42 10473248-3 1999 Norepinephrine axons, labeled with dopamine-beta-hydroxylase antibodies, formed a bed of fine varicose axons that co-distributed with the cholinergic cells. Norepinephrine 0-14 dopamine beta-hydroxylase Homo sapiens 35-60 10189964-2 1999 In particular, hormones such as angiotensin II, endothelin 1, norepinephrine and prostaglandin F2 alpha which bind to and activate cardiomyocyte membrane receptors coupled to the Gq class of GTP binding proteins have been implicated in the development and ultimate decompensation of cardiac hypertrophy. Norepinephrine 62-76 endothelin 1 Mus musculus 48-60 9879729-0 1998 ORL1 receptor-mediated inhibition by nociceptin of noradrenaline release from perivascular sympathetic nerve endings of the rat tail artery. Norepinephrine 51-64 prepronociceptin Rattus norvegicus 37-47 9771557-6 1998 T-2 treatment increased 5-hydroxy-3-indoleacetic acid and serotonin throughout the brain, and produced a transient increase in norepinephrine in the nucleus raphe magnus and a temporary decrease in the substantia nigra. Norepinephrine 127-141 brachyury 2 Rattus norvegicus 0-3 9722148-12 1998 Considering the importance of N-methyl-D-aspartate receptor activation and of noradrenaline in cognitive processes, the effects of gp120 and V3 described here may be relevant to the pathology of AIDS dementia. Norepinephrine 78-91 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 131-143 9763470-1 1998 Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline and is selectively expressed in noradrenergic and adrenergic neurons and neuroendocrine cells. Norepinephrine 72-85 dopamine beta-hydroxylase Homo sapiens 0-25 9763470-1 1998 Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline and is selectively expressed in noradrenergic and adrenergic neurons and neuroendocrine cells. Norepinephrine 72-85 dopamine beta-hydroxylase Homo sapiens 27-30 9763638-16 1998 Forskolin, an activator of endogenous adenylate cyclase, and 3-isobutyl-1-methylxanthine, a phosphodiesterase inhibitor, mimicked the ability of noradrenaline to increase both steady-state pHi and rates of pHi recovery from imposed acid loads, as did Sp-cAMPS, a selective activator of cAMP-dependent protein kinase. Norepinephrine 145-158 glucose-6-phosphate isomerase Rattus norvegicus 189-192 9763638-16 1998 Forskolin, an activator of endogenous adenylate cyclase, and 3-isobutyl-1-methylxanthine, a phosphodiesterase inhibitor, mimicked the ability of noradrenaline to increase both steady-state pHi and rates of pHi recovery from imposed acid loads, as did Sp-cAMPS, a selective activator of cAMP-dependent protein kinase. Norepinephrine 145-158 glucose-6-phosphate isomerase Rattus norvegicus 206-209 9763638-19 1998 Noradrenaline also increased steady-state pHi and rates of pHi recovery from imposed acid loads in cultured postnatal rat hippocampal neurones. Norepinephrine 0-13 glucose-6-phosphate isomerase Rattus norvegicus 42-45 9763638-19 1998 Noradrenaline also increased steady-state pHi and rates of pHi recovery from imposed acid loads in cultured postnatal rat hippocampal neurones. Norepinephrine 0-13 glucose-6-phosphate isomerase Rattus norvegicus 59-62 9763638-22 1998 We conclude that noradrenaline increases the activity of the Na+-H+ exchanger in rat hippocampal neurones, probably by inducing an alkaline shift in the pHi dependence of the antiport, thereby raising steady-state pHi. Norepinephrine 17-30 glucose-6-phosphate isomerase Rattus norvegicus 153-156 9763638-22 1998 We conclude that noradrenaline increases the activity of the Na+-H+ exchanger in rat hippocampal neurones, probably by inducing an alkaline shift in the pHi dependence of the antiport, thereby raising steady-state pHi. Norepinephrine 17-30 glucose-6-phosphate isomerase Rattus norvegicus 214-217 9641484-1 1998 Nepicastat (RS-25560-197) is a novel, selective, and potent inhibitor of dopamine beta-hydroxylase, which modulates catecholamine levels (reduces norepinephrine and elevates dopamine) in cardiovascular tissues. Norepinephrine 146-160 dopamine beta-hydroxylase Rattus norvegicus 73-98 9754635-5 1998 Intraperitoneal injections of various doses (0.2-2 mg kg(-1)) of noradrenaline and adrenaline dose-dependently induced hepatic c-fos and c-jun mRNA levels. Norepinephrine 65-78 FBJ osteosarcoma oncogene Mus musculus 127-132 9754635-6 1998 The time-course study showed that there was an increase in c-fos and c-jun mRNA levels within 15 min, which reached a peak at 30 min, and returned to the basal levels 1-2 h after noradrenaline or adrenaline injection (2 mg kg(-1), i.p.). Norepinephrine 179-192 FBJ osteosarcoma oncogene Mus musculus 59-64 9754635-23 1998 The results suggest that noradrenaline elicits the hepatic c-fos and c-jun mRNA responses by stimulating alpha1-adrenergic receptors, whereas in the case of adrenaline, this is elicited by stimulating both alpha1- and beta2-adrenergic receptors in mice. Norepinephrine 25-38 FBJ osteosarcoma oncogene Mus musculus 59-64 9754639-6 1998 TPA+ (0.3-3 microM) potentiated the contractile responses induced by noradrenaline and ATP, whilst, TPA+ (10 microM) concentration-dependently reduced the agonist-induced contractions. Norepinephrine 69-82 plasminogen activator, tissue type Rattus norvegicus 0-3 9590190-10 1998 In stepwise multiple regression analysis, NPY alone explained blood pressure elevation when analyzed with fluid overload and angiotensin II, renin, noradrenaline, and adrenaline levels. Norepinephrine 148-161 neuropeptide Y Homo sapiens 42-45 9730267-0 1998 The role of MAO-A and MAO-B in the metabolic degradation of noradrenaline in human arteries. Norepinephrine 60-73 monoamine oxidase A Homo sapiens 12-17 9730267-12 1998 In conclusion, three major differences distinguish the metabolism of noradrenaline by human arteries from that observed in other species: (1) the large predominance of deamination over O-methylation; (2) the extremely high formation of DOMA; and (3) the relative lack of selectivity of clorgyline and selegiline for MAO-A and B, respectively. Norepinephrine 69-82 monoamine oxidase A Homo sapiens 316-327 9483533-6 1998 The norepinephrine-induced calcium current inhibition was mediated by alpha 2-adrenergic receptors; it was mimicked by UK 14304, an alpha 2-adrenergic receptor agonist and blocked by idazoxan, an alpha 2-adrenergic receptor antagonist, but not affected by prazosin or propanolol (alpha 1 and beta adrenergic antagonists, respectively). Norepinephrine 4-18 adrenoceptor alpha 1D Homo sapiens 280-296 9462871-0 1997 Activation of fos in mouse amygdala by local infusion of norepinephrine or atipamezole. Norepinephrine 57-71 FBJ osteosarcoma oncogene Mus musculus 14-17 9364061-1 1997 Prostaglandin E2 (PGE2) mediates the stimulatory effect of norepinephrine (NE) on the secretion of luteinizing hormone-releasing hormone (LHRH), the neuropeptide controlling reproductive function. Norepinephrine 59-73 gonadotropin releasing hormone 1 Mus musculus 99-136 9364061-1 1997 Prostaglandin E2 (PGE2) mediates the stimulatory effect of norepinephrine (NE) on the secretion of luteinizing hormone-releasing hormone (LHRH), the neuropeptide controlling reproductive function. Norepinephrine 59-73 gonadotropin releasing hormone 1 Mus musculus 138-142 9359850-4 1997 The cold-induced increase in VEGF mRNA was abolished by surgical sympathetic denervation, but mimicked by administration of noradrenaline or a beta3-adrenoceptor agonist CL316,243, indicating the critical role of the beta-adrenergic pathway in VEGF expression in BAT. Norepinephrine 124-137 vascular endothelial growth factor A Rattus norvegicus 29-33 9337215-8 1997 Plasma norepinephrine and endothelin increased by more than fivefold with chronic pacing and remained elevated with AT1 Ang II blockade. Norepinephrine 7-21 angiogenin Sus scrofa 120-123 9403317-4 1997 Norepinephrine and epinephrine operate through differential recruitment of alpha 2- and beta-AR subtypes on the basis of their relative affinity for the different subtypes (the relative order of affinity is alpha 2 > beta 1 > or = beta 2 > beta 3 for norepinephrine). Norepinephrine 0-14 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 249-255 9288945-6 1997 However, maximal cAMP accumulation was significantly reduced in response to various beta3-adrenergic agonists, including endogenous catecholamines, (-)-epinephrine and (-)-norepinephrine, the non-selective agonist (-)-isoproterenol, and the beta3-adrenergic selective agonist CGP 12177A. Norepinephrine 168-186 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 84-89 9288945-6 1997 However, maximal cAMP accumulation was significantly reduced in response to various beta3-adrenergic agonists, including endogenous catecholamines, (-)-epinephrine and (-)-norepinephrine, the non-selective agonist (-)-isoproterenol, and the beta3-adrenergic selective agonist CGP 12177A. Norepinephrine 168-186 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 241-246 9253353-0 1997 Influence of circulating epinephrine and norepinephrine on insulin-like growth factor binding protein-1 in humans. Norepinephrine 41-55 insulin like growth factor binding protein 1 Homo sapiens 59-103 9253353-1 1997 The aim of the present study was to investigate the influence of circulating epinephrine (Epi) and norepinephrine (Norepi) on serum insulin-like growth factor binding protein-1 (IGFBP-1) concentrations. Norepinephrine 99-113 insulin like growth factor binding protein 1 Homo sapiens 132-176 9253353-1 1997 The aim of the present study was to investigate the influence of circulating epinephrine (Epi) and norepinephrine (Norepi) on serum insulin-like growth factor binding protein-1 (IGFBP-1) concentrations. Norepinephrine 99-113 insulin like growth factor binding protein 1 Homo sapiens 178-185 9253353-1 1997 The aim of the present study was to investigate the influence of circulating epinephrine (Epi) and norepinephrine (Norepi) on serum insulin-like growth factor binding protein-1 (IGFBP-1) concentrations. Norepinephrine 115-121 insulin like growth factor binding protein 1 Homo sapiens 132-176 9253353-1 1997 The aim of the present study was to investigate the influence of circulating epinephrine (Epi) and norepinephrine (Norepi) on serum insulin-like growth factor binding protein-1 (IGFBP-1) concentrations. Norepinephrine 115-121 insulin like growth factor binding protein 1 Homo sapiens 178-185 9253353-7 1997 Norepi resulted in a slight increase in circulating IGFBP-1 (43 +/- 6 to 54 +/- 8 nmol/L, NS). Norepinephrine 0-6 insulin like growth factor binding protein 1 Homo sapiens 52-59 9247147-1 1997 Mouse brown adipocytes in primary culture were shown to contain high levels of mRNA for interleukin-1alpha (IL-1alpha) which could be further stimulated up to 9-fold by norepinephrine (NE). Norepinephrine 169-183 interleukin 1 alpha Mus musculus 88-106 9247147-1 1997 Mouse brown adipocytes in primary culture were shown to contain high levels of mRNA for interleukin-1alpha (IL-1alpha) which could be further stimulated up to 9-fold by norepinephrine (NE). Norepinephrine 169-183 interleukin 1 alpha Mus musculus 108-117 9214397-1 1997 Neuropeptide Y (NPY) is a peptide hormone that is expressed, stored, and released in sympathetic neurones together with noradrenaline. Norepinephrine 120-133 neuropeptide Y Homo sapiens 0-14 9214397-1 1997 Neuropeptide Y (NPY) is a peptide hormone that is expressed, stored, and released in sympathetic neurones together with noradrenaline. Norepinephrine 120-133 neuropeptide Y Homo sapiens 16-19 9160936-12 1997 Adrenomedullin, a novel peptide with known vasodilator properties, relaxed vascular smooth muscle in all three groups and also attenuated the pressor response to norepinephrine. Norepinephrine 162-176 adrenomedullin Canis lupus familiaris 0-14 9213209-4 1997 The effects of subtype-selective NPY analogs on the stimulation-induced noradrenaline release were studied. Norepinephrine 72-85 neuropeptide Y Homo sapiens 33-36 9145932-6 1997 Altogether, MGL mice showed a more restless behavior, a higher rectal temperature, and much higher brain (+17%) and urine (+200%) noradrenaline levels than the MGH animals. Norepinephrine 130-143 C-type lectin domain family 10, member A Mus musculus 12-15 9226400-3 1997 NPY (10(-7) M) did not affect either basal tone or spontaneous rhythmic contractions of the isolated intravesical ureter, but significantly enhanced the increases in both tone and frequency of phasic activity elicited by noradrenaline (10(-6) and 10(-5) M). Norepinephrine 221-234 neuropeptide Y Equus caballus 0-3 9226400-6 1997 Submaximal concentrations of NPY (10(-8) M) significantly increased the sensitivity of ureteral arteries to noradrenaline. Norepinephrine 108-121 neuropeptide Y Equus caballus 29-32 9226400-9 1997 Thus, NPY potentiates the phasic contractions and tone elicited by noradrenaline through Y2-receptors, whereas it both contracts and potentiates noradrenaline vasoconstriction in ureteral arteries via Y1-receptors. Norepinephrine 67-80 neuropeptide Y Equus caballus 6-9 9054858-1 1997 BACKGROUND: Although norepinephrine induces cardiac hypertrophy by activating protein kinase A and C through beta- and alpha 1-adrenoceptors, respectively, protein kinase A has been reported to inhibit cell growth in many other cell types. Norepinephrine 21-35 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 78-154 9054858-1 1997 BACKGROUND: Although norepinephrine induces cardiac hypertrophy by activating protein kinase A and C through beta- and alpha 1-adrenoceptors, respectively, protein kinase A has been reported to inhibit cell growth in many other cell types. Norepinephrine 21-35 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 78-94 9152617-1 1997 Noradrenaline (NA) is one of the most important neurotransmitters involved in the regulation of gonadotropin-releasing hormone (GnRH) secretion. Norepinephrine 0-13 gonadotropin releasing hormone 1 Mus musculus 96-126 9152617-1 1997 Noradrenaline (NA) is one of the most important neurotransmitters involved in the regulation of gonadotropin-releasing hormone (GnRH) secretion. Norepinephrine 0-13 gonadotropin releasing hormone 1 Mus musculus 128-132 9120070-7 1997 We show here that amnesiac, a neurological mutation, and Dihydroxyphenylalanine decarboxylasetemperature sensitive, a mutation that interferes with synthesis of dopamine, norepinephrine, and serotonin, result in slower heart rate and reduced regularity across a normal range of temperatures for these flies. Norepinephrine 171-185 amnesiac Drosophila melanogaster 18-26 9039093-1 1997 Neuropeptide Y coexists with norepinephrine in sympathetic nerves and is coreleased into the circulation on sympathetic activation. Norepinephrine 29-43 neuropeptide Y Homo sapiens 0-14 9023776-0 1997 Protein kinase A-mediated enhancement of miniature IPSC frequency by noradrenaline in rat cerebellar stellate cells. Norepinephrine 69-82 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 0-16 8982508-13 1996 This effect was antagonized by the selective protein kinase A (PKA) antagonist, Rp-8-chloroadenosine 3",5"-cyclic monophosphorothioate (RClcAMPS, 300 microM), suggesting that PKA activation enhances basal noradrenaline biosynthesis in sympathetic nerve terminals. Norepinephrine 205-218 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 45-61 8982508-13 1996 This effect was antagonized by the selective protein kinase A (PKA) antagonist, Rp-8-chloroadenosine 3",5"-cyclic monophosphorothioate (RClcAMPS, 300 microM), suggesting that PKA activation enhances basal noradrenaline biosynthesis in sympathetic nerve terminals. Norepinephrine 205-218 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 63-66 8982508-13 1996 This effect was antagonized by the selective protein kinase A (PKA) antagonist, Rp-8-chloroadenosine 3",5"-cyclic monophosphorothioate (RClcAMPS, 300 microM), suggesting that PKA activation enhances basal noradrenaline biosynthesis in sympathetic nerve terminals. Norepinephrine 205-218 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 175-178 8952593-8 1996 Atrial natriuretic factor, however, increased at 7 and 14 days of servo-controlled norepinephrine, and plasma renin activity increased on day 14 of norepinephrine infusion. Norepinephrine 83-97 natriuretic peptide A Canis lupus familiaris 0-25 8987112-0 1996 Different classes of PAF-antagonists block norepinephrine-induced vascular escape and tachyphylaxis in the isolated rabbit kidney. Norepinephrine 43-57 PCNA clamp associated factor Homo sapiens 21-24 8790370-4 1996 Thus, connexin32-containing gap junctions are essential in mouse liver for maximal intercellular propagation of the noradrenaline signal from the periportal (upstream) area, where it is received from sympathetic nerve endings, to perivenous (downstream) hepatocytes. Norepinephrine 116-129 gap junction protein, beta 1 Mus musculus 6-16 8878061-9 1996 It is concluded that ethanol predominantly inhibits NMDA receptors containing a high proportion of the NMDAR2B subunit (as reflected by high sensitivity to ifenprodil), i.e. the NMDA receptors involved in stimulation of noradrenaline, 5-hydroxytryptamine and GABA release. Norepinephrine 220-233 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 103-110 8666149-5 1996 Insulin-induced hypoglycemia (plasma glucose = 1.9 +/- 0.1 mmol/l) activated parasympathetic nerves to the pancreas as assessed by increased plasma pancreatic polypeptide (PP) levels (delta = 135.0 +/- 36.8 pmol/l, P < 0.01), produced sympathoadrenal activation as assessed by elevations of plasma epinephrine (EPI) (delta = 22.3 +/- 2.95 nmol/l, P < 0.0005) and norepinephrine (NE) (delta = 3.72 +/- 0.77 mmol/l, P < 0.0025) and increased plasma immunoreactive glucagon (IRG) (delta = 920 +/- 294 ng/l, P < 0.025). Norepinephrine 369-383 insulin Canis lupus familiaris 0-7 8661508-2 1996 CATH.a cells express several differentiated neuronal characteristics including medium and light chain neurofilament proteins, synaptophysin, tyrosine hydroxylase, and dopamine beta-hydroxylase; they synthesize dopamine and norepinephrine. Norepinephrine 223-237 cathepsin H Mus musculus 0-4 8667208-3 1996 In dopamine transporter expressing cells, the maximal transport rate (Vmax) of MPP+, dopamine and noradrenaline was the same, but in noradrenaline transporter expressing cells the Vmax of MPP+ and dopamine was only one-half of the Vmax of noradrenaline. Norepinephrine 98-111 solute carrier family 6 member 3 Homo sapiens 3-23 8627519-10 1996 Thus, only antidepressant drugs that affect norepinephrine uptake (i.e., imipramine, desipramine and nisoxetine) antagonized swim stress-induced Fos-LI. Norepinephrine 44-58 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 145-148 8792338-6 1996 The overall distribution of neurons expressing GTP cyclohydrolase I mRNA was observed to correspond exactly to the known distribution of the dopamine, norepinephrine/epinephrine and serotonin-containing cell groups. Norepinephrine 151-165 GTP cyclohydrolase 1 Rattus norvegicus 47-67 8795072-3 1996 Adrenomedullin-like immunoreactivity occurred in noradrenaline- and adrenaline-producing cells in the adrenal gland. Norepinephrine 49-62 adrenomedullin Rattus norvegicus 0-14 8626551-5 1996 In human heart, AUF1 mRNA and protein was significantly increased in individuals with myocardial failure, a condition associated with increases in the beta-adrenergic receptor agonist norepinephrine. Norepinephrine 184-198 heterogeneous nuclear ribonucleoprotein D Homo sapiens 16-20 8740147-9 1996 When MAO-B was also inhibited, 10 nmol/l amezinium caused 84% inhibition of the deamination of noradrenaline by MAO-A in the lungs. Norepinephrine 95-108 monoamine oxidase B Rattus norvegicus 5-10 8846821-14 1996 Tyr-W-MIF-1 is mediated through spinal mu2-receptors, and is modulated by norepinephrine and alpha 2-adrenoceptors. Norepinephrine 74-88 predicted gene 4924 Mus musculus 6-11 8692281-0 1996 Inhibition of noradrenaline release via presynaptic 5-HT1D alpha receptors in human atrium. Norepinephrine 14-27 5-hydroxytryptamine receptor 1D Homo sapiens 52-64 8788483-10 1996 In strips of atrial appendages, 5-HT receptor agonists (e.g. 5-HT, 5-CT and sumatriptan) inhibited noradrenaline release at potencies which are correlated with their ki values at 5-HT1D alpha and 5-HT1D beta receptors. Norepinephrine 99-112 5-hydroxytryptamine receptor 1D Homo sapiens 179-191 8548058-3 1995 Human GAL administration significantly reduced both the release of basal norepinephrine and the response to insulin-induced hypoglycemia, whereas it attenuated the epinephrine response by 26%, with the hGAL-induced decrease in epinephrine release failing to achieve statistical significance. Norepinephrine 73-87 galanin and GMAP prepropeptide Homo sapiens 6-9 8548058-3 1995 Human GAL administration significantly reduced both the release of basal norepinephrine and the response to insulin-induced hypoglycemia, whereas it attenuated the epinephrine response by 26%, with the hGAL-induced decrease in epinephrine release failing to achieve statistical significance. Norepinephrine 73-87 galanin and GMAP prepropeptide Homo sapiens 202-206 8548058-5 1995 We conclude that GAL receptor stimulation exerts an inhibitory effect on basal and insulin-induced hypoglycemia-stimulated release of norepinephrine. Norepinephrine 134-148 galanin and GMAP prepropeptide Homo sapiens 17-20 7503321-4 1995 Intravenous administration of human adrenomedullin (10, 100, 1,000, and 3,000 pmol/kg, n = 6) caused a dose-dependent reduction in mean arterial pressure (0 +/- 2, -1 +/- 2, -19 +/- 2, and -29 +/- 4 mmHg, respectively) concomitant with increases in heart rate, renal sympathetic nerve activity, plasma renin activity, and plasma norepinephrine. Norepinephrine 329-343 adrenomedullin Homo sapiens 36-50 7487925-3 1995 In contrast to white fat, the level of lipoprotein lipase mRNA in brown adipose tissue was increased by noradrenaline and isoprenaline. Norepinephrine 104-117 lipoprotein lipase Mus musculus 39-57 7562554-1 1995 In previous investigations, we have demonstrated that cholinesterase inhibitors such as physostigmine (PHY) and heptylphysostigmine (HEP) elicit a significant and simultaneous increase in acetylcholine (ACh) and norepinephrine (NE) levels in the rat cortex. Norepinephrine 212-226 butyrylcholinesterase Rattus norvegicus 54-68 7666200-10 1995 In the CNS, dopamine, norepinephrine, epinephrine, 5-HT, and histamine cell groups all express VMAT2. Norepinephrine 22-36 solute carrier family 18 member A2 Rattus norvegicus 95-100 8545048-0 1995 Atrial natriuretic factor enhances norepinephrine uptake in circumventricular organs, locus coeruleus and nucleus tractus solitarii of the rat. Norepinephrine 35-49 natriuretic peptide A Rattus norvegicus 0-25 7498270-1 1995 The role of nitric oxide and cyclo-oxygenase products in the platelet-activating factor (PAF)-induced hyporesponsiveness to noradrenaline was investigated in pithed rats. Norepinephrine 124-137 PCNA clamp associated factor Rattus norvegicus 61-87 7498270-1 1995 The role of nitric oxide and cyclo-oxygenase products in the platelet-activating factor (PAF)-induced hyporesponsiveness to noradrenaline was investigated in pithed rats. Norepinephrine 124-137 PCNA clamp associated factor Rattus norvegicus 89-92 7498270-2 1995 Infusion of PAF (30 ng/kg/min) for 60 min reduced the mean arterial blood pressure and impaired the pressor responses to noradrenaline (10 ng/kg, 100 ng/kg, 1 microgram/kg). Norepinephrine 121-134 PCNA clamp associated factor Rattus norvegicus 12-15 7498270-7 1995 These results suggest that nitric oxide contributes to the PAF-induced hyporesponsiveness to noradrenaline and that cyclo-oxygenase products do not play a major role in this hyporesponsiveness. Norepinephrine 93-106 PCNA clamp associated factor Rattus norvegicus 59-62 7653623-0 1995 Effects of PKC downregulation on norepinephrine- and prostaglandin F2 alpha-induced contraction in rat aorta. Norepinephrine 33-47 protein kinase C, gamma Rattus norvegicus 11-14 7651358-4 1995 KMD-3213 inhibited norepinephrine-induced increases in intracellular Ca2+ concentrations in alpha 1a-AR-expressing Chinese hamster ovary cells with an IC50 of 0.32 nM but had a much weaker inhibitory effect on the alpha 1b- and alpha 1d-ARs. Norepinephrine 19-33 calcium voltage-gated channel subunit alpha1 A Homo sapiens 92-100 8548177-0 1995 Noradrenaline contractions of human prostate mediated by alpha 1A-(alpha 1c-) adrenoceptor subtype. Norepinephrine 0-13 calcium voltage-gated channel subunit alpha1 A Homo sapiens 57-90 7612155-4 1995 In addition, c-fos induction in response to acute restraint stress was down-regulated by chronic, but not acute, administration of tranylcypromine or imipramine, two drugs that nonselectively increase synaptic levels of norepinephrine and serotonin by inhibition of monoamine oxidase or neurotransmitter reuptake, respectively. Norepinephrine 220-234 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 13-18 7612155-5 1995 Moreover, chronic administration of desipramine or sertraline, selective re-uptake inhibitors of norepinephrine, or serotonin, respectively, also significantly down-regulated the induction of c-fos mRNA in response to restraint stress. Norepinephrine 97-111 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 192-197 7727409-2 1995 The resonance Raman spectra of hTH1 complexed with dopamine, noradrenaline, tyramine, and catechol have been studied and compared to those obtained for TH isolated from bovine adrenal glands or rat phaeochromocytoma tissue. Norepinephrine 61-74 negative elongation factor complex member C/D Homo sapiens 31-35 7601207-8 1995 Neuropeptide Y inhibits acetylcholine release due to the noradrenaline release mediated by stimulation of a receptor distinct from neuropeptide Y Y1 and Y2 receptors, located on adrenergic neurons. Norepinephrine 57-70 pro-neuropeptide Y Cavia porcellus 0-14 7655416-5 1995 NPY also augmented the contractile responses to prostaglandin F2 alpha, norepinephrine, and histamine, but not to serotonin. Norepinephrine 72-86 neuropeptide Y Canis lupus familiaris 0-3 7605896-13 1995 In the isolated perfused working rat heart, norepinephrine (3 x 10(-8) M) increased the expression of the proto-oncogenes c-fos and c-myc after 30 and 60 minutes, respectively. Norepinephrine 44-58 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 122-127 7891145-1 1995 We investigated whether interleukin-1 (IL-1) activity in the rat hypothalamus was increased by immobilization stress (IS), and whether pretreatment with an interleukin-1 receptor antagonist (IL-1Ra) is capable of inhibiting IS-induced elevations of hypothalamic norepinephrine (NE), dopamine (DA), and serotonin (5-HT) and the levels of their metabolites as well as of plasma adrenocorticotropic hormone (ACTH). Norepinephrine 262-276 interleukin 1 receptor antagonist Rattus norvegicus 156-189 7891145-1 1995 We investigated whether interleukin-1 (IL-1) activity in the rat hypothalamus was increased by immobilization stress (IS), and whether pretreatment with an interleukin-1 receptor antagonist (IL-1Ra) is capable of inhibiting IS-induced elevations of hypothalamic norepinephrine (NE), dopamine (DA), and serotonin (5-HT) and the levels of their metabolites as well as of plasma adrenocorticotropic hormone (ACTH). Norepinephrine 262-276 interleukin 1 receptor antagonist Rattus norvegicus 191-197 7753398-8 1995 Replacing Ca2+ with Mg2+ or adding 0.8 mM of Cd2+ reversibly blocked the norepinephrine effects. Norepinephrine 73-87 Cd2 molecule Rattus norvegicus 45-48 7628838-1 1995 Catecholamines (adrenaline and noradrenaline) stimulate adipocyte lipolysis via three beta-adrenoceptor subtypes beta 1, beta 2 and beta 3. Norepinephrine 31-44 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 113-119 7730990-19 1995 These observations indicate that morphine acts near or within the supraoptic nucleus to block CCK-evoked noradrenaline release presynaptically. Norepinephrine 105-118 cholecystokinin Rattus norvegicus 94-97 7995014-2 1994 Although not all features of its antiParkinson action are known, studies that used brains obtained at autopsy from patients who took l-deprenyl show that the selective inhibition of MAO-B with a concomitant increase of phenylethylamine and dopamine, but not of serotonin or noradrenaline, in the basal ganglia may be responsible for its mode of action. Norepinephrine 274-287 monoamine oxidase B Homo sapiens 182-187 7721026-7 1994 MAO-B inhibitors can selectively and dramatically increase the level of beta-phenylethylamine, which has been shown to potentiate dopamine and noradrenaline function in the central nervous system. Norepinephrine 143-156 monoamine oxidase B Homo sapiens 0-5 7962564-6 1994 Moreover, adrenomedullin showed intimate correlations with norepinephrine, atrial natriuretic peptide, and cAMP in plasma (r = 0.625, P < 0.001; r = 0.656, P < 0.001; and r = 0.462, P < 0.001; respectively). Norepinephrine 59-73 adrenomedullin Homo sapiens 10-24 8069683-0 1994 Atrial natriuretic factor effects on norepinephrine uptake in discrete telencephalic and diencephalic nuclei of the rat. Norepinephrine 37-51 natriuretic peptide A Rattus norvegicus 0-25 8069683-1 1994 Atrial natriuretic factor (ANF) effects on norepinephrine (NE) uptake in olfactory bulb, preoptic, periventricular, supraoptic, paraventricular and arcuate nuclei and median eminence of the rat were studied. Norepinephrine 43-57 natriuretic peptide A Rattus norvegicus 0-25 8069683-1 1994 Atrial natriuretic factor (ANF) effects on norepinephrine (NE) uptake in olfactory bulb, preoptic, periventricular, supraoptic, paraventricular and arcuate nuclei and median eminence of the rat were studied. Norepinephrine 43-57 natriuretic peptide A Rattus norvegicus 27-30 7910371-10 1994 Overall, the rank order of efficacy of these agonists to elicit stimulation of adenylyl cyclase activity by alpha 2C10 was epinephrine = norepinephrine = UK-14304 > BHT-933 > BHT-920 > oxymetazoline. Norepinephrine 137-151 adrenoceptor alpha 2A Homo sapiens 108-118 8294418-0 1994 Phorbol esters and norepinephrine destabilize alpha 1B-adrenergic receptor mRNA in vascular smooth muscle cells. Norepinephrine 19-33 alpha-1B adrenergic receptor Oryctolagus cuniculus 46-74 8294418-1 1994 The mechanism by which norepinephrine (NE) down-regulates alpha 1B-adrenergic receptor (alpha-AR) mRNA was studied in rabbit aortic smooth muscle cells. Norepinephrine 23-37 alpha-1B adrenergic receptor Oryctolagus cuniculus 58-86 8294418-1 1994 The mechanism by which norepinephrine (NE) down-regulates alpha 1B-adrenergic receptor (alpha-AR) mRNA was studied in rabbit aortic smooth muscle cells. Norepinephrine 23-37 alpha-1B adrenergic receptor Oryctolagus cuniculus 88-96 8201228-6 1994 Atrial natriuretic peptide-induced changes in plasma norepinephrine concentrations were significantly higher in normal than in cirrhotic rats (1827 +/- 834 vs. 59 +/- 46 pg/ml, mean +/- S.E., respectively). Norepinephrine 53-67 natriuretic peptide A Rattus norvegicus 0-26 8138103-8 1993 Norepinephrine which might leak from varicosities of chromatic nerve fibers by virtue of the action of prolactin molecules may be responsible for melanosome aggregation. Norepinephrine 0-14 prolactin Oreochromis niloticus 103-112 8274274-2 1993 Here, we show that the modulation of this current by norepinephrine, serotonin, and histamine is mediated by protein kinase A in hippocampal CA1 neurons. Norepinephrine 53-67 carbonic anhydrase 1 Homo sapiens 141-144 7904926-0 1993 Atrial natriuretic factor inhibits noradrenaline release in the presence of angiotensin II and III in the rat hypothalamus. Norepinephrine 35-48 natriuretic peptide A Rattus norvegicus 0-25 8277975-6 1993 Adenosine deaminase at the concentration of 0.5 mu.ml-1 decreased but at that of 2.0 mu.ml-1 increased noradrenaline overflow. Norepinephrine 103-116 adenosine deaminase Rattus norvegicus 0-19 8227954-0 1993 Neuropeptide Y potentiates noradrenaline-evoked vasoconstriction by an intracellular calcium-dependent mechanism. Norepinephrine 27-40 pro-neuropeptide Y Cavia porcellus 0-14 8227954-1 1993 The potentiating effect of neuropeptide Y (NPY) was examined by testing the influence of putative inhibitors of calcium entry on the NPY-enhanced contractile response to noradrenaline in the guinea pig uterine artery. Norepinephrine 170-183 pro-neuropeptide Y Cavia porcellus 133-136 8227954-3 1993 NPY (100-300 nM) enhanced noradrenaline-evoked vasoconstriction. Norepinephrine 26-39 pro-neuropeptide Y Cavia porcellus 0-3 8227954-4 1993 The potentiation by NPY was most prominent in low noradrenaline concentrations (30-300 nM) and the pD10 (-log molar concentration of agonist eliciting 10% of maximum contraction) value was increased from 6.43 +/- 0.07 to 6.97 +/- 0.11 (P < 0.001, n = 6). Norepinephrine 50-63 pro-neuropeptide Y Cavia porcellus 20-23 8227954-6 1993 The intracellular calcium chelator quin-2 AM selectively abolished the NPY-induced enhancement of the contractile response to noradrenaline. Norepinephrine 126-139 pro-neuropeptide Y Cavia porcellus 71-74 8336141-6 1993 Histamine-stimulated catecholamine secretion was also greater in epinephrine cells than in norepinephrine cells, whereas high K+, bradykinin, phorbol 12,13-dibutyrate, and angiotensin II all caused greater secretion from norepinephrine cells than from epinephrine cells. Norepinephrine 221-235 kininogen 1 Bos taurus 130-140 8343229-0 1993 Effects of neurotensin on norepinephrine release in blood vessels of spontaneously hypertensive rats. Norepinephrine 26-40 neurotensin Rattus norvegicus 11-22 8343229-3 1993 In studies with male standard Wistar rats, endogenous norepinephrine release during periarterial nerve stimulation was inhibited by neurotensin in a dose-dependent manner. Norepinephrine 54-68 neurotensin Rattus norvegicus 132-143 8343229-7 1993 These results show that neurotensin could have a modulatory effect on noradrenergic activity and cause a decrease in stimulation-evoked norepinephrine release from vascular adrenergic neurons. Norepinephrine 136-150 neurotensin Rattus norvegicus 24-35 8343229-8 1993 The lesser reduction of pressor responses and norepinephrine release by neurotensin in SHR might suggest an insufficient regulation of vascular adrenergic transmission by the peptide hormone in hypertension. Norepinephrine 46-60 neurotensin Rattus norvegicus 72-83 8232769-10 1993 This embryonic GR may modulate the development of inter alia neuro-endocrine areas such as the paraventricular and arcuate nuclei and arousal-related areas such as the central 5-hydroxytryptamine and noradrenaline neuronal systems. Norepinephrine 200-213 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 15-17 8514914-0 1993 Noradrenaline in the brain of the South African clawed frog Xenopus laevis: a study with antibodies against noradrenaline and dopamine-beta-hydroxylase. Norepinephrine 0-13 dopamine beta-hydroxylase (dopamine beta-monooxygenase) L homeolog Xenopus laevis 126-151 8484505-9 1993 However, up to a dose of 30 micrograms/kg (A30), a dose-dependent decrease in the maximum percent changes of both epinephrine and norepinephrine occurred in response to INT. Norepinephrine 130-144 immunoglobulin kappa variable 1-17 Homo sapiens 43-46 19912907-10 1993 AVP had significant inhibitory effects on noradrenaline-provoked melatonin secretion in vitro. Norepinephrine 42-55 arginine vasopressin Bos taurus 0-3 8383262-4 1993 The effect of norepinephrine on calcium concentrations was less affected by thyrotropin in PC C13 transformed by the adenovirus E1A oncogene. Norepinephrine 14-28 branched chain keto acid dehydrogenase E1 subunit alpha Rattus norvegicus 128-131 1473014-4 1992 Administration of IRAP largely prevented the effects of IL-1 alpha or IL-1 beta on the elevation of plasma corticosterone and the concomitant increase in hypothalamic norepinephrine metabolism, but failed to alter the responses to LPS. Norepinephrine 167-181 interleukin 1 receptor antagonist Mus musculus 18-22 1429734-7 1992 The addition of PKC enhanced phosphorylation of p145 under conditions of fully reconstituted Ca(2+)-activated norepinephrine secretion. Norepinephrine 110-124 POM121 transmembrane nucleoporin Rattus norvegicus 48-52 1362158-8 1992 As TFMPP exhibits a close similarity to 5-HT in these experiments, the 5-HT receptor subtype being activated to induce noradrenaline release may either be a 5-HT1C or a 5-HT1S subtype. Norepinephrine 119-132 5-hydroxytryptamine receptor 2C Rattus norvegicus 157-163 1358654-2 1992 Seven days after the intracerebroventricular administration of 0.25 and 0.5 mumol 2,4,5-trihydroxyamphetamine, hippocampal tryptophan hydroxylase (TPH) activity was reduced to 5 and 1% of control, respectively, while norepinephrine (NE) concentration was depressed to 10 and 18% of control. Norepinephrine 217-231 tryptophan hydroxylase 1 Rattus norvegicus 147-150 1333978-2 1992 The effectiveness of electrical stimulation of the locus coeruleus and of microiontophoretic application of norepinephrine (NE) in suppressing the firing activity of CA3 pyramidal neurons was studied in the dorsal hippocampus. Norepinephrine 108-122 carbonic anhydrase 3 Rattus norvegicus 166-169 1415729-0 1992 ANF inhibits norepinephrine-stimulated fluid absorption in rat proximal straight tubules. Norepinephrine 13-27 natriuretic peptide A Rattus norvegicus 0-3 1356432-6 1992 These studies indicate that, in addition to the dopamine system, the norepinephrine and serotonin systems also play prominent roles in the activation of zif268 and c-fos by cocaine and amphetamine. Norepinephrine 69-83 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 164-169 1392057-6 1992 injection of increasing doses of endothelin-1 (ET) (0.01-0.3 microgram) caused a weak but long-lasting and dose-dependent vasoconstriction of the thoracic aorta; its effect was less potent than that of angiotensin II or norepinephrine when their peak responses were compared. Norepinephrine 220-234 endothelin-1 Oryctolagus cuniculus 33-45 1392057-6 1992 injection of increasing doses of endothelin-1 (ET) (0.01-0.3 microgram) caused a weak but long-lasting and dose-dependent vasoconstriction of the thoracic aorta; its effect was less potent than that of angiotensin II or norepinephrine when their peak responses were compared. Norepinephrine 220-234 endothelin-1 Oryctolagus cuniculus 47-49 1385164-4 1992 In addition to its contractile activity, NPY greatly reduced the maximal response to vasoactive intestinal peptide (VIP), noradrenaline (NA), substance P (SP) and 5-hydroxytryptamine (5-HT), without affecting their pD2 values. Norepinephrine 122-135 pro-neuropeptide Y Cavia porcellus 41-44 1629106-6 1992 The catecholamine- (epinephrine plus norepinephrine) to-insulin molar ratio was correlated with Ra during the early period (r = 0.52, P less than 0.01) and over the entire period of exercise (r = 0.66, P less than 0.0001). Norepinephrine 37-51 insulin Canis lupus familiaris 56-63 1348566-2 1992 Out of the established endocrine cell types only insulin (B-) cells contained immunoreactivity for serotonin and noradrenaline. Norepinephrine 113-126 insulin Cavia porcellus 49-56 2000991-0 1991 Adenosine deaminase and adenosine attenuate ventricular arrhythmias caused by norepinephrine. Norepinephrine 78-92 adenosine deaminase Canis lupus familiaris 0-19 2000991-3 1991 Ventricular tachycardia caused by 200 ng.kg-1.min-1 norepinephrine was reduced from 1.2 +/- 0.3 to 0.1 +/- 0.1 bouts/10 cardiac cycles (P less than 0.05) by adenosine deaminase. Norepinephrine 52-66 adenosine deaminase Canis lupus familiaris 157-176 2000991-6 1991 We conclude that both adenosine and adenosine deaminase significantly attenuate norepinephrine-induced ventricular arrhythmias. Norepinephrine 80-94 adenosine deaminase Canis lupus familiaris 36-55 1908674-2 1991 A single injection of norepinephrine (2.5 micrograms/kg to 2.5 mg/kg) led to transient increases in the levels of both c-fos and c-myc mRNA. Norepinephrine 22-36 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 119-124 1671204-6 1991 Tissue culture in the presence of insulin increased the basal rate of lipolysis and increased the ratio of the rate of noradrenaline-stimulated/isoprenaline-stimulated lipolysis, indicating a decrease in the 2-adrenergic effect of noradrenaline. Norepinephrine 119-132 LOC105613195 Ovis aries 34-41 1671204-6 1991 Tissue culture in the presence of insulin increased the basal rate of lipolysis and increased the ratio of the rate of noradrenaline-stimulated/isoprenaline-stimulated lipolysis, indicating a decrease in the 2-adrenergic effect of noradrenaline. Norepinephrine 231-244 LOC105613195 Ovis aries 34-41 34968668-8 2022 The TGF-alpha siRNA-treated HF rats also exhibited lower plasma norepinephrine levels and improved peripheral manifestations of HF. Norepinephrine 64-78 transforming growth factor alpha Rattus norvegicus 4-13 34862463-10 2021 Finally, MEK1/2 inhibition suppressed reserpine, norepinephrine, and mTOR-induced antimicrobial responses. Norepinephrine 49-63 mitogen-activated protein kinase kinase 2 Gallus gallus 9-15 34713714-14 2021 Finally, exposure of the renal epithelial cells to norepinephrine in vitro led to downregulation of GLP-1R expression but upregulation of neprilysin expression and activity. Norepinephrine 51-65 glucagon-like peptide 1 receptor Rattus norvegicus 100-106 34713714-14 2021 Finally, exposure of the renal epithelial cells to norepinephrine in vitro led to downregulation of GLP-1R expression but upregulation of neprilysin expression and activity. Norepinephrine 51-65 membrane metallo-endopeptidase Rattus norvegicus 138-148 34392133-7 2021 Not the selective norepinephrine reuptake inhibitor reboxetine but the selective serotonin reuptake inhibitors fluvoxamine and sertraline upregulated the PGD2-induced osteoprotegerin release, which was further amplified by morphine. Norepinephrine 18-32 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 167-182 34425806-5 2021 The activity of beta-ARs was modulated by an agonist, norepinephrine (NE), and antagonists, including propranolol, atenolol, nebivolol, and nadolol. Norepinephrine 54-68 alanyl-tRNA synthetase 1 Homo sapiens 16-24 34445205-8 2021 The reduced expression of NT-3, TrkC, and NET, and the lack of molecular complexes in T cells of patients with schizophrenia may lead to a peripheral dysregulation of intracellular signaling pathways and an abnormal reuptake of norepinephrine (NE) by NET. Norepinephrine 228-242 neurotrophic receptor tyrosine kinase 3 Homo sapiens 32-36 34104992-3 2021 One such mechanism involves the direct inhibition by corticosteroid hormones of monoamine transport mediated by the "uptake2" transporter, organic cation transporter 3 (OCT3), a high-capacity, low-affinity transporter for norepinephrine, epinephrine, dopamine, serotonin, and histamine. Norepinephrine 222-236 OCTN3 Homo sapiens 139-167 35597283-8 2022 Consistent with this model, we show that CatE is an FeII-dependent 2,3-catechol dioxygenase with broad substrate specificity, YwnB is a NAD(P)H-dependent quinone reductase capable of reducing the oxidized and cyclized norepinephrine, adrenochrome, and YhdA is capable of reducing a number of FeIII-complexes, including PiuA-binding transport substrates. Norepinephrine 218-232 cathepsin E Homo sapiens 41-45 35568869-7 2022 GSK3 inactivation also prevents B2AR agonist norepinephrine or MOR agonist DAMGO from affecting MDA-MB-231 and MDA-MB-468 cell proliferation. Norepinephrine 45-59 adrenoceptor beta 2 Homo sapiens 32-36 35174415-3 2022 Aims of the study were to monitor the effect of a single session of dTMS on body temperature in subjects with obesity, and to correlate the dTMS-induced changes in body temperature with activation of the SNS (epinephrine and norepinephrine release). Norepinephrine 225-239 tms Drosophila melanogaster 140-144 35245122-1 2022 The alpha2A adrenergic receptor (alpha2AAR) is a G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor that mediates important physiological functions in response to the endogenous neurotransmitters norepinephrine and epinephrine, as well as numerous chemically distinct drugs. Norepinephrine 224-238 adrenoceptor alpha 2A Homo sapiens 4-31 35245122-1 2022 The alpha2A adrenergic receptor (alpha2AAR) is a G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor that mediates important physiological functions in response to the endogenous neurotransmitters norepinephrine and epinephrine, as well as numerous chemically distinct drugs. Norepinephrine 224-238 adrenoceptor alpha 2A Homo sapiens 33-42 35245122-3 2022 Here, we report the cryo-electron microscopy structures of the human alpha2AAR-GoA complex bound to norepinephrine and three imidazoline derivatives (brimonidine, dexmedetomidine, and oxymetazoline). Norepinephrine 100-114 adrenoceptor alpha 2A Homo sapiens 69-78 35245122-5 2022 Further structural analyses uncover different molecular determinants between alpha2AAR and betaARs for recognition of norepinephrine and key regions that determine the G protein coupling selectivity. Norepinephrine 118-132 adrenoceptor alpha 2A Homo sapiens 77-86 2763865-3 1989 Norepinephrine levels were elevated in the dorsal amygdala of rats injected with 10 micrograms of CCK as well as in the septum of rats injected with 1 and 10 micrograms of CCK. Norepinephrine 0-14 cholecystokinin Rattus norvegicus 98-101 2763865-3 1989 Norepinephrine levels were elevated in the dorsal amygdala of rats injected with 10 micrograms of CCK as well as in the septum of rats injected with 1 and 10 micrograms of CCK. Norepinephrine 0-14 cholecystokinin Rattus norvegicus 172-175 2544113-6 1989 Norepinephrine-precontracted vascular strips from ADR rats were more sensitive to ANF (ED50: 1.7 x 10(-8) M) than those from sham-operated animals (ED50: 1.5 x 10(-7) M). Norepinephrine 0-14 natriuretic peptide A Rattus norvegicus 82-85 2714445-4 1989 3-Hydroxytyramine (DA) and norepinephrine (NE) also increased the cellular NGF mRNA content. Norepinephrine 27-41 nerve growth factor Mus musculus 75-78 2471016-9 1989 In norepinephrine-treated animals, adipose tissue lipoprotein lipase activity was enhanced (+30%) by doxazosin. Norepinephrine 3-17 lipoprotein lipase Mesocricetus auratus 50-68 2761120-1 1989 Repetitive intermittent cold exposure (5 degrees C, 6 h/day, 4 weeks) (ICE) resulted in the same cold adaptability as assessed by an enhanced cold tolerance (less drop of colonic temperature at -5 degrees C) and nonshivering thermogenesis (NST) (greater noradrenaline-induced heat production) as that elicited by continuous cold exposure (5 degrees C, 4 weeks) (CA) in rats. Norepinephrine 254-267 caspase 1 Rattus norvegicus 71-74 2657281-4 1989 ZAC reduces acid and peptic secretion, increases mucus secretion, protects mucosa from disruption by aspirin and reverses the reduction of blood flow caused by noradrenaline. Norepinephrine 160-173 PLAG1 like zinc finger 1 Homo sapiens 0-3 2566928-1 1989 The relationship between noradrenaline and neuropeptide Y (NPY) release was investigated in the in situ perfused guinea pig heart with intact sympathetic innervation. Norepinephrine 25-38 pro-neuropeptide Y Cavia porcellus 59-62 2566928-4 1989 When two subsequent stimulations (12 Hz; each for 1 min) were performed in the same heart, addition of noradrenaline (10 microM) 5 min prior to the second stimulation reduced NPY overflow by 43 +/- 10%. Norepinephrine 103-116 pro-neuropeptide Y Cavia porcellus 175-178 2566928-7 1989 Exogenous NPY (100 nM) attenuated the stimulated overflow of noradrenaline by 30 +/- 6%. Norepinephrine 61-74 pro-neuropeptide Y Cavia porcellus 10-13 2789414-8 1989 These data suggest that the increased responsiveness to L-5-HTP caused by T3 involves an indirect (norepinephrine-mediated) rather than a direct effect on serotonergic processes. Norepinephrine 99-113 kinocilin Mus musculus 56-59 2735135-3 1989 Cortical noradrenaline levels in mice with Rb (8, 17) 1IEM were the lowest and brain stem levels the highest among the three groups investigated. Norepinephrine 9-22 Robertsonian translocation, Chr 8 and 17, Inst of Experimental Medicine Leningrad 1 Mus musculus 43-58 2905622-3 1988 The present electrophysiological study was undertaken to characterize the adrenoceptor mediating the suppressant effect of microiontophoretically applied norepinephrine (NE) on CA1 and CA3 dorsal hippocampus pyramidal neurons of the rat. Norepinephrine 154-168 carbonic anhydrase 3 Rattus norvegicus 185-188 2467974-3 1988 Stimulation-evoked noradrenaline release and pressor responses were inhibited by substance P and neurotensin. Norepinephrine 19-32 neurotensin Rattus norvegicus 97-108 2467974-6 1988 These results showed that substance P and neurotensin could affect the presynaptic site of the blood vessels and cause a decrease in electrically stimulated noradrenaline release from the vascular adrenergic neurons. Norepinephrine 157-170 neurotensin Rattus norvegicus 42-53 3247254-1 1988 This investigation was undertaken in the unrestrained rat to determine the localized effect of neurotensin (NT) on the profile of release and turnover of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) within the hypothalamus. Norepinephrine 154-168 neurotensin Rattus norvegicus 95-106 3247254-1 1988 This investigation was undertaken in the unrestrained rat to determine the localized effect of neurotensin (NT) on the profile of release and turnover of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) within the hypothalamus. Norepinephrine 154-168 neurotensin Rattus norvegicus 108-110 3401255-6 1988 Adenosine deaminase (0.5 U/ml) increased basal as well as theophylline- and norepinephrine-induced lipolysis. Norepinephrine 76-90 adenosine deaminase Rattus norvegicus 0-19 3071444-4 1988 In the case of noradrenaline not only a normalization but also an explicit overcompensation could be observed by insulin treatment. Norepinephrine 15-28 insulin Canis lupus familiaris 113-120 2848203-9 1988 Furthermore, the beta 2-adrenoceptor-induced facilitation of noradrenaline release may in part be mediated by local stimulation of angiotensin II synthesis, which may occur by increased formation or activation of renin and/or increased availability of angiotensinogen. Norepinephrine 61-74 adrenoceptor beta 2 Homo sapiens 17-36 2841837-6 1988 These results led to the following conclusions: Dopexamine hydrochloride stimulates the heart by 2 mechanisms--(1) baroreceptor-mediated release of norepinephrine resulting from hypotension produced by beta 2 adrenoceptor and DA1 dopamine receptor-mediated vasodilatation, and (2) potentiation of the released norepinephrine due to prevention of norepinephrine uptake by sympathetic nerves. Norepinephrine 148-162 tropomyosin 2 Homo sapiens 226-229 2969977-3 1988 In the present study, we utilized an in vitro perfused hydronephrotic rat kidney model to assess directly the actions of ANP on renal microvessels during norepinephrine (NE)-induced renal vasoconstriction. Norepinephrine 154-168 natriuretic peptide A Rattus norvegicus 121-124 3224030-5 1988 The release of norepinephrine from the postganglionic fiber of the superior cervical ganglia controls the production of melatonin in the pineal by regulating the activity of serotonin-N-acetyltransferase. Norepinephrine 15-29 aralkylamine N-acetyltransferase Homo sapiens 174-203 2969821-0 1988 Atrial natriuretic factor inhibits norepinephrine release in an adrenergic clonal cell line (PC12). Norepinephrine 35-49 natriuretic peptide A Rattus norvegicus 0-25 2454064-3 1988 Every preparation treated with somatostatin, and one tissue treated with NPY, showed an enhanced noradrenaline-induced contraction. Norepinephrine 97-110 neuropeptide Y Canis lupus familiaris 73-76 3420006-2 1988 Results of these studies indicate that norepinephrine and carbachol evoke pharmacologically and temporally distinctive patterns of antral gastrin release. Norepinephrine 39-53 gastrin Rattus norvegicus 138-145 3420006-3 1988 Dose-response experiments indicate that norepinephrine is approximately 10,000 times more potent on a molar basis than carbachol in stimulating antral gastrin release. Norepinephrine 40-54 gastrin Rattus norvegicus 151-158 3420006-4 1988 Adrenergic (norepinephrine, isoproterenol) stimulation of antral gastrin release was prevented by propranolol, and cholinergic- (carbachol) mediated peptide release was blocked by both atropine and pirenzepine. Norepinephrine 12-26 gastrin Rattus norvegicus 65-72 2839012-6 1988 Catecholamines (epinephrine, norepinephrine and isoproterenol) reduced the basal secretion of ANP, whereas acetylcholine stimulated the release of ANP. Norepinephrine 29-43 natriuretic peptide A Rattus norvegicus 94-97 2836013-11 1988 Bretylium tosylate incubation to prevent noradrenaline release produced a small but significant enhancement of the inhibitory effect of NPY on EFS at high frequencies. Norepinephrine 41-54 pro-neuropeptide Y Cavia porcellus 136-139 2840274-5 1988 The DHEA-S concentration in the medium was significantly increased by angiotensin-II (10(-7)M), noradrenalin (3 X 10(-5) M), adrenalin (3 X 10(-5) M) or alpha-melanocyte-stimulating hormone (alpha-MSH, 10(-7) M), none of which was associated with cAMP production. Norepinephrine 96-108 sulfotransferase family 2A member 1 Homo sapiens 4-10 3171572-7 1988 In general, noradrenaline-containing neuronal cell body areas showed monoamine oxidase A, and 5-hydroxytryptamine-rich areas monoamine oxidase B. Norepinephrine 12-25 monoamine oxidase B Rattus norvegicus 125-144 3143879-3 1988 A 1-hr pretreatment, but not a 24-hr pretreatment, with the monoamine oxidase B inhibitor, L-deprenyl (10 mg/kg ip), prevented the depletion of norepinephrine by xylamine. Norepinephrine 144-158 monoamine oxidase B Rattus norvegicus 60-79 2890660-5 1987 Superfusion with 10 muM norepinephrine produced a biphasic rise in ANP secretion with a peak response 2.5-fold above baseline secretion. Norepinephrine 24-38 natriuretic peptide A Rattus norvegicus 67-70 3440821-4 1987 It is suggested that NPY is released from cardiac sympathetic neurons with noradrenaline following activation of the sympathetic nerve and inhibits cardiac vagal action. Norepinephrine 75-88 neuropeptide Y Canis lupus familiaris 21-24 2890079-6 1987 The intravenous injection of ovine GH (100 micrograms/kg) or equimolar amounts of SRIF (7.5 micrograms/kg) produced in the hepatic portal circulation a transient but statistically significant rise of serotonin and a concomitant reduction in the concentration of dopamine, norepinephrine, and epinephrine. Norepinephrine 272-286 somatotropin Canis lupus familiaris 35-37 3436374-7 1987 The MPi was well correlated with the direct measurement of mean arterial pressure before (r = 0.918, p less than 0.001) and during (r = 0.903, p less than 0.001) elevation of arterial pressure via norepinephrine infusion. Norepinephrine 197-211 mannose phosphate isomerase Rattus norvegicus 4-7 2889453-3 1987 Conversely, EN, DA, and norepinephrine (NE) decreased the NGF content in growing cells. Norepinephrine 24-38 nerve growth factor Mus musculus 58-61 2442626-2 1987 Noradrenaline (NA) released from sympathetic nerves acts on alpha 1-adrenoceptors to increase cytosolic Ca2+ and promote smooth muscle contraction. Norepinephrine 0-13 carbonic anhydrase 2 Homo sapiens 104-107 2890184-3 1987 Somatostatin potentiates the venoconstrictive activity of noradrenaline, adrenaline and dopamine, but not that of 5-hydroxytryptamine and tyramine. Norepinephrine 58-71 somatostatin Homo sapiens 0-12 3313435-5 1987 In cells treated with adenosine deaminase (0.5 U/ml) or with theophylline (0.5 mM), PGI2 (40 nM) inhibited the lipolytic effect of norepinephrine (5 microM) and nicotinic acid acted synergistically with PGI2 at this level. Norepinephrine 131-145 adenosine deaminase Rattus norvegicus 22-41 2882402-2 1987 Norepinephrine had a potent inhibitory effect on I-CRF release in a dose-dependent manner at 0.1 nM-1 microM concentrations, but dopamine did not. Norepinephrine 0-14 regenerating family member 1 alpha Rattus norvegicus 49-54 2882402-6 1987 These results suggest that norepinephrine inhibits I-CRF release mainly through the beta-adrenergic receptor and partially through the alpha 1-receptor. Norepinephrine 27-41 regenerating family member 1 alpha Rattus norvegicus 51-56 3595711-0 1987 Increases in CSF norepinephrine associated with the onset of digoxin-induced arrhythmias. Norepinephrine 17-31 colony stimulating factor 2 Canis lupus familiaris 13-16 3595711-2 1987 A continuous peripheral digoxin infusion produced significant increases in CSF norepinephrine just prior to arrhythmogenesis in anesthetized dogs. Norepinephrine 79-93 colony stimulating factor 2 Canis lupus familiaris 75-78 3611599-1 1987 In agreement with the inhibition of dopamine-beta-hydroxylase by exposure to CS2, the extension of exposure time from 4 to 16 h increased dopamine concentrations in the hypothalmus and adrenals, and decreased noradrenaline concentration in the hypothalmus. Norepinephrine 209-222 calsyntenin 2 Rattus norvegicus 77-80 2880980-4 1987 However, the digoxin-induce increase in CSF noradrenaline was decreased significantly in apomorphine-pretreated animals. Norepinephrine 44-57 colony stimulating factor 2 Canis lupus familiaris 40-43 2880980-6 1987 As with apomorphine, pimozide-pretreated animals accumulated significantly less noradrenaline in CSF compared with control dogs. Norepinephrine 80-93 colony stimulating factor 2 Canis lupus familiaris 97-100 3466164-7 1986 These features and the presence of pi ADH in human liver imply a physiological role for pi ADH in the degradation of circulating epinephrine and norepinephrine. Norepinephrine 145-159 aldo-keto reductase family 1 member A1 Homo sapiens 38-41 3466164-7 1986 These features and the presence of pi ADH in human liver imply a physiological role for pi ADH in the degradation of circulating epinephrine and norepinephrine. Norepinephrine 145-159 aldo-keto reductase family 1 member A1 Homo sapiens 91-94 2876643-6 1986 Injection of neostigmine (5 X 10(-8) mol), an inhibitor of cholinesterase, into the ventricle resulted in the increase of not only glucose, but also glucagon, epinephrine, and norepinephrine in the hepatic venous plasma. Norepinephrine 176-190 butyrylcholinesterase Rattus norvegicus 59-73 3536002-0 1986 CCK and other peptides modulate hypothalamic norepinephrine release in the rat: dependence on hunger or satiety. Norepinephrine 45-59 cholecystokinin Rattus norvegicus 0-3 3019887-2 1986 Norepinephrine, epinephrine, and phenylephrine stimulated tonin release, an effect that was inhibited by phentolamine but not by propranolol, whereas isoproterenol, carbachol, histamine, and serotonin did not stimulate tonin release. Norepinephrine 0-14 kallikrein 1-related peptidase C2 Rattus norvegicus 58-63 3019887-2 1986 Norepinephrine, epinephrine, and phenylephrine stimulated tonin release, an effect that was inhibited by phentolamine but not by propranolol, whereas isoproterenol, carbachol, histamine, and serotonin did not stimulate tonin release. Norepinephrine 0-14 kallikrein 1-related peptidase C2 Rattus norvegicus 195-200 3019887-6 1986 The apparent molecular size of immunoreactive tonin released into the medium under basal and norepinephrine-stimulated conditions was similar to that of standard tonin by gel exclusion chromatography. Norepinephrine 93-107 kallikrein 1-related peptidase C2 Rattus norvegicus 46-51 3021940-8 1986 Angiotensin II secreted from the vascular bed by the beta 2-adrenoceptor stimulation acts locally to facilitate norepinephrine release. Norepinephrine 112-126 adrenoceptor beta 2 Homo sapiens 53-72 3016179-1 1986 Pineal cyclic AMP and cyclic GMP are regulated by norepinephrine (NE) acting through alpha 1- and beta-adrenoceptors. Norepinephrine 50-64 5'-nucleotidase, cytosolic II Homo sapiens 29-32 2871469-9 1986 Catecholamine had different effects on TRH levels in RMN and the controls; this might be due to the excess accumulation of noradrenaline in the RMN brain. Norepinephrine 123-136 thyrotropin releasing hormone Mus musculus 39-42 3085873-0 1986 Stimulation by gastrin-releasing peptide, neurotensin and DN1417, a novel TRH analog, of dopamine and norepinephrine release from perifused rat hypothalamic fragments in vitro. Norepinephrine 102-116 gastrin releasing peptide Rattus norvegicus 15-40 3742254-0 1986 Effects of neurotensin on regional concentrations of norepinephrine in rat brain. Norepinephrine 53-67 neurotensin Rattus norvegicus 11-22 3742254-1 1986 The effects of intraventricular administration of either 7.5 or 30 micrograms neurotensin on norepinephrine concentrations were examined in several brain regions at 5 or 30 min post-injection. Norepinephrine 93-107 neurotensin Rattus norvegicus 78-89 2941312-0 1986 Atrial natriuretic factor inhibits norepinephrine release evoked by sympathetic nerve stimulation in isolated perfused rat mesenteric arteries. Norepinephrine 35-49 natriuretic peptide A Rattus norvegicus 0-25 2420199-1 1986 We investigated the role of calcium and calmodulin as intracellular mediators of kallikrein and tonin release induced by norepinephrine (NE). Norepinephrine 121-135 kallikrein 1-related peptidase C2 Rattus norvegicus 96-101 3005829-8 1986 In competition studies, alpha-adrenergic antagonists and agonists inhibited the binding of 125I-rau-pAPC with a potency order consistent with an interaction at alpha 2-adrenergic receptors (rauwolscine greater than phentolamine greater than prazosin; clonidine greater than (-)-epinephrine greater than (-)-norepinephrine greater than dopamine greater than (+)-epinephrine). Norepinephrine 303-321 protocadherin 8 Homo sapiens 100-104 3754217-3 1986 Neuropeptide Y, on a molar basis, was 7 and 120 times less potent than noradrenaline and angiotensin, respectively, in producing a 50 mm Hg rise in mean arterial blood pressure. Norepinephrine 71-84 neuropeptide Y Felis catus 0-14 3754217-5 1986 Neuropeptide Y had a similar potency to noradrenaline in causing these resistance changes. Norepinephrine 40-53 neuropeptide Y Felis catus 0-14 2935881-5 1986 Furthermore, ANF suppressed the compensatory increase of norepinephrine excretion secondary to adrenalectomy. Norepinephrine 57-71 natriuretic peptide A Rattus norvegicus 13-16 3008207-7 1986 As both serotonin and norepinephrine are preferentially metabolized by MAO-A rather than MAO-B, an increased availability of serotonin (the precursor of melatonin) or enhanced noradrenergic function might mediate the melatonin changes observed to follow MAO-A but not MAO-B inhibition. Norepinephrine 22-36 monoamine oxidase B Homo sapiens 89-94 3008207-7 1986 As both serotonin and norepinephrine are preferentially metabolized by MAO-A rather than MAO-B, an increased availability of serotonin (the precursor of melatonin) or enhanced noradrenergic function might mediate the melatonin changes observed to follow MAO-A but not MAO-B inhibition. Norepinephrine 22-36 monoamine oxidase B Homo sapiens 268-273 3010387-6 1986 Thirdly, NPY and PYY act prejunctionally in that they suppress the release of noradrenaline from sympathetic nerve endings upon stimulation; this was studied in the rat vas deferens. Norepinephrine 78-91 peptide YY Rattus norvegicus 17-20 3010387-10 1986 The NPY- and PYY-induced suppression of noradrenaline release from the prostatic portion of the rat vas deferens was reproduced by PYY 13-36 but not by the shorter fragments nor by desamido-NPY. Norepinephrine 40-53 peptide YY Rattus norvegicus 13-16 3010387-10 1986 The NPY- and PYY-induced suppression of noradrenaline release from the prostatic portion of the rat vas deferens was reproduced by PYY 13-36 but not by the shorter fragments nor by desamido-NPY. Norepinephrine 40-53 peptide YY Rattus norvegicus 131-134 2946967-0 1986 Norepinephrine-induced acute renal failure: beneficial effects of atrial natriuretic factor. Norepinephrine 0-14 natriuretic peptide A Rattus norvegicus 66-91 2946967-1 1986 The effect of the atrial natriuretic factor (ANF) on early norepinephrine-induced acute renal failure (ARF) was investigated. Norepinephrine 59-73 natriuretic peptide A Rattus norvegicus 18-43 2946967-1 1986 The effect of the atrial natriuretic factor (ANF) on early norepinephrine-induced acute renal failure (ARF) was investigated. Norepinephrine 59-73 natriuretic peptide A Rattus norvegicus 45-48 2856724-2 1985 Synthetic ANF caused a relaxation of the renal vessels when these were submaximally activated with noradrenaline or serotonin, but had no effect on the responses of the other vessels to these agonists. Norepinephrine 99-112 natriuretic peptide A Rattus norvegicus 10-13 2932194-3 1985 Synthetic ANF was found to cause relaxation of the renal vessels when these were sub-maximally activated with K+, noradrenaline or 5-hydroxytryptamine, but had no effect on the responses of the other vessels to these agonists. Norepinephrine 114-127 natriuretic peptide A Rattus norvegicus 10-13 2995061-2 1985 A first series of experiments served to assess the responsiveness of CA3 hippocampal pyramidal neurons to microiontophoretically applied serotonin (5-HT) and norepinephrine (NE). Norepinephrine 158-172 carbonic anhydrase 3 Rattus norvegicus 69-72 4041988-2 1985 An injection of ovine GH (6 or 100 micrograms/kg) into a cephalic vein produced in the hepatic portal circulation a transient, statistically significant rise of serotonin and a concomitant significant reduction in the concentration of dopamine, norepinephrine, and epinephrine. Norepinephrine 245-259 somatotropin Canis lupus familiaris 22-24 3872460-2 1985 N-Methyl-4-phenylpyridine (MPP+), a metabolite of MPTP formed by monoamine oxidase B, is accumulated into striatal and cerebral cortical synaptosomes by the dopamine and norepinephrine uptake systems, respectively, whereas MPTP itself is not accumulated. Norepinephrine 170-184 monoamine oxidase B Rattus norvegicus 65-84 2988261-1 1985 Noradrenaline (NA) exerts its physiological and pharmacological effects in the central nervous system by interacting with specific receptor sites which are divided into four subtypes, namely alpha-1, alpha-2, beta-1 and beta-2 adrenoceptors. Norepinephrine 0-13 hemoglobin, beta adult minor chain Mus musculus 220-226 2863929-6 1985 The "rules" for coexistence are not clear, since somatostatin coexist in some instances with norepinephrine, in other cases with GABA, and probably with other classical transmitters as well. Norepinephrine 93-107 somatostatin Homo sapiens 49-61 7218373-3 1981 Depressant responses of cortical neurones to noradrenaline were also markedly potentiated by weak background application of p-TA. Norepinephrine 45-58 pre T-cell antigen receptor alpha Rattus norvegicus 124-128 6256117-8 1980 Tonin potentiated the contraction induced by noradrenaline in aortic strips from hypertensive and normotensive rats. Norepinephrine 45-58 kallikrein 1-related peptidase C2 Rattus norvegicus 0-5 6256117-10 1980 In the aortic and mesenteric strips from normal rabbits, tonin produced not only potentiation to noradrenaline but direct contraction. Norepinephrine 97-110 kallikrein 1-related peptidase C2 Rattus norvegicus 57-62 6256117-12 1980 The potentiation to noradrenaline and the direct effect of tonin were not affected by a variety of antagonists but were blocked by a calcium ion antagonist, verapamil, suggesting that tonin may act directly on vascular smooth muscle through mechanisms which might be mediated by calcium ions. Norepinephrine 20-33 kallikrein 1-related peptidase C2 Rattus norvegicus 184-189 6968237-1 1980 The responsiveness of hippocampal CA3 pyramidal neurons to microiontophoretic applications of serotonin (5-HT), norepinephrine (NE), gamma-aminobutyric acid (GABA) and isoproterenol (ISO) was assessed in rats following 5,7-dihydroxy-tryptamine (5,7-DHT) and 6-hydroxydopamine (6-OHDA) pretreatments and bilateral locus coeruleus lesions. Norepinephrine 112-126 carbonic anhydrase 3 Rattus norvegicus 34-37 6252494-0 1980 The kinetics of norepinephrine-induced stimulation of serotonin N-acetyltransferase in bovine pineal gland. Norepinephrine 16-30 serotonin N-acetyltransferase Bos taurus 54-83 6993660-3 1980 In response to stimulation by norepinephrine and serotonin, aortic strips from 2 to 28 day AHR developed the same tension as controls, whereas aortas of 6 and 14 day AHR had reduced maximal responses. Norepinephrine 30-44 aryl hydrocarbon receptor Rattus norvegicus 91-94 6993660-3 1980 In response to stimulation by norepinephrine and serotonin, aortic strips from 2 to 28 day AHR developed the same tension as controls, whereas aortas of 6 and 14 day AHR had reduced maximal responses. Norepinephrine 30-44 aryl hydrocarbon receptor Rattus norvegicus 166-169 6105122-1 1980 In vitro incubation studies with bovine parathyroid gland slices compared the relative responsiveness of parathyroid hormone (PTH) secretion to isoprotherenol, epinephrine or norepinephrine. Norepinephrine 175-189 parathyroid hormone Bos taurus 105-124 6167608-4 1980 The "apparent affinity" for neurotensin (pD2 = 7.5 +/- 0.3, S.D., n = 10) was about 10 times less than for angiotensin II while higher than for both the other peptides and for norepinephrine. Norepinephrine 176-190 neurotensin Rattus norvegicus 28-39 7353588-1 1980 After in vivo ligation for 24 of the cat hypogastric nerve, large amounts of noradrenaline (NA) and dopamine beta-hydroxylase (DBH) accumulated in the nerve segment immediately proximal to the ligature (P 1). Norepinephrine 77-90 crystallin gamma F, pseudogene Homo sapiens 203-206 43064-2 1979 The leakage of 125IHSA (human serum albumin) into the brains from rats given adrenaline was significantly larger than in the brains from rats given noradrenaline or angiotensin. Norepinephrine 148-161 albumin Rattus norvegicus 30-43 217278-5 1979 The potentiation of exogenous norepinephrine by AII, AIII, and [des-Asp1-Arg2]AII was inhibited by [Sar1-Ile8]AII (110%, 113%, and 108%, respectively) and by [Ile7]AIII (50%, 64%, 91%, respectively). Norepinephrine 30-44 arginase 2 Rattus norvegicus 73-77 217278-6 1979 We conclude that AII possesses the capacity both to increase norpinephrine release during sympathetic nerve stimulation and to decrease norepinephrine reuptake, whereas AIII and [des-Asp1-Arg2]AII decrease norepinephrine release and reuptake. Norepinephrine 206-220 arginase 2 Rattus norvegicus 188-192 232613-0 1979 Effect on renal function and renin secretion of noradrenaline infused into the renal artery. Norepinephrine 48-61 renin Canis lupus familiaris 29-34 232613-3 1979 Noradrenaline infusion resulted in a significant elevation of renin secretion associated with marked vasoconstriction. Norepinephrine 0-13 renin Canis lupus familiaris 62-67 232613-6 1979 The simultaneous infusion of noradrenaline enhanced renin release without affecting renal haemodynamics or reducing Na-excretion. Norepinephrine 29-42 renin Canis lupus familiaris 52-57 220287-1 1979 C-6 glial tumor cells treated with norepinephrine and sodium azide accumulated cyclic GMP to concentrations approximately 10-fold greater than the sum of the separate responses. Norepinephrine 35-49 5'-nucleotidase, cytosolic II Homo sapiens 86-89 375113-4 1979 Renal kallikrein is released by high arterial pressure, vasodilators, low doses of noradrenaline, angiotensin II, mineralocorticoids and rapid volume expansion. Norepinephrine 83-96 kallikrein related peptidase 4 Homo sapiens 6-16 106542-1 1979 Effects of biogenic amines--noradrenaline and serotonin--on phosphorylase, acid alpha-glucosidase (gamma-amilase), glycogen synthetase as well as on content of glycogen in rat liver tissue, heart and skeletal muscles were studied in vivo. Norepinephrine 28-41 alpha glucosidase Rattus norvegicus 75-97 106542-3 1979 Noradrenaline, administered into rats, caused a decrease in activity of acid alpha-glucosidase in heart and liver tissues and did not affect the enzymatic activity in skeletal muscles. Norepinephrine 0-13 alpha glucosidase Rattus norvegicus 72-94 740049-8 1978 Both neurotensin and [Gln4]-neurotensin also accelerated the disappearance of dopamine, noradrenaline and 5-hydroxytryptamine after inhibition of monoamine synthesis. Norepinephrine 88-101 neurotensin Rattus norvegicus 5-16 740049-8 1978 Both neurotensin and [Gln4]-neurotensin also accelerated the disappearance of dopamine, noradrenaline and 5-hydroxytryptamine after inhibition of monoamine synthesis. Norepinephrine 88-101 neurotensin Rattus norvegicus 28-39 570404-1 1978 The effect of PLP on the noradrenaline-induced relaxation of coronary arteries was studied in vitro, after known inhibitor of COMT, Pyrogallol. Norepinephrine 25-38 proteolipid protein 1 Homo sapiens 14-17 570404-2 1978 Relaxation of response to noradrenaline were increased by PLP. Norepinephrine 26-39 proteolipid protein 1 Homo sapiens 58-61 570404-4 1978 It is concluded that PLP enhances the response of coronary smooth muscle to noradrenaline by inhibiting a enzymatic pathway for the inactivation of catecolamines. Norepinephrine 76-89 proteolipid protein 1 Homo sapiens 21-24 206750-5 1978 Met- and leu-enkephalin (10(-7)-10(-5) M) decreased the high potassium induced [3H]-norepinephrine release from vas deferens, while substance P (10(-6) M) significantly increased it. Norepinephrine 84-98 prodynorphin Mus musculus 9-23 668387-0 1978 Plasma renin activity in acute renal failure induced by norepinephrine infusion in unilaterally nephrectomized dogs. Norepinephrine 56-70 renin Canis lupus familiaris 7-12 578406-3 1977 Daily exposure to 4.0 mg/l CS2 (first exposure 24 h after the first phenobarbitone injection) for 4 h prevented the decline in susceptibility on the 3rd and 4th days after phenobarbitone, when the reaction of unexposed rats to noradrenaline returned to normal. Norepinephrine 227-240 calsyntenin 2 Rattus norvegicus 27-30 11370235-10 1976 The data indicate that in pentobarbital anesthetized dogs, the increase in growth hormone secretion produced by L-dopa is mediated by norepinephrine, rather than dopamine, that the site of action of the norepinephrine is central, above the median eminence and inside the "blood-brain barrier", and that the norepinephrine acts via alpha-adrenergic receptors. Norepinephrine 134-148 somatotropin Canis lupus familiaris 75-89 11370235-10 1976 The data indicate that in pentobarbital anesthetized dogs, the increase in growth hormone secretion produced by L-dopa is mediated by norepinephrine, rather than dopamine, that the site of action of the norepinephrine is central, above the median eminence and inside the "blood-brain barrier", and that the norepinephrine acts via alpha-adrenergic receptors. Norepinephrine 203-217 somatotropin Canis lupus familiaris 75-89 11370235-10 1976 The data indicate that in pentobarbital anesthetized dogs, the increase in growth hormone secretion produced by L-dopa is mediated by norepinephrine, rather than dopamine, that the site of action of the norepinephrine is central, above the median eminence and inside the "blood-brain barrier", and that the norepinephrine acts via alpha-adrenergic receptors. Norepinephrine 203-217 somatotropin Canis lupus familiaris 75-89 185109-0 1976 Additive effects of norepinephrine and cyclic AMP on the activation of the protein kinase from adipose tissue. Norepinephrine 20-34 KIT proto-oncogene receptor tyrosine kinase Rattus norvegicus 75-89 185109-4 1976 Wtih intact tissue, norepinephrine not only stimulates the protein kinase activity measured without exogenous cyclic AMP but also the total activity measured in the presence of cyclic AMP (5 X 10(-6) M); thus the effect of norepinephrine, obtained during incubation of the tissue, and that of cyclic AMP, added to the soluble fraction after incubation, were additive. Norepinephrine 20-34 KIT proto-oncogene receptor tyrosine kinase Rattus norvegicus 59-73 185109-9 1976 These results suggest that the effects of norepinephrine on the protein kinase of the fat pads cannot be completely explained by the model of Brostrom and colleagues. Norepinephrine 42-56 KIT proto-oncogene receptor tyrosine kinase Rattus norvegicus 64-78 1276544-12 1976 8 A large dose of insulin, 10 iu, transiently reduced HAVR and caused a weak and very transient inhibition of the effect of test doses of noradrenaline. Norepinephrine 138-151 insulin Canis lupus familiaris 18-25 24271344-3 1976 We found that PDEA can be released from brain particulate fraction by 1 muM norepinephrine, dopamine, adenosine, and histamine in the presence of ATP and a purified cAMP-dependent protein kinase; in similar conditions, serotonin is ineffective in concentrations up to 0.1 mM. Norepinephrine 76-90 phosphodiesterase 6A Homo sapiens 14-18 24271344-4 1976 Norepinephrine and dopamine activate the adenylate cyclase activity of those preparations from which they release the PDEA. Norepinephrine 0-14 phosphodiesterase 6A Homo sapiens 118-122 24271344-5 1976 Norepinephrine is more potent than dopamine in releasing PDEA from the particulate fraction of cerebellum, whereas dopamine is more active than norepinephrine in releasing PDEA from the particulate fraction of striatum. Norepinephrine 0-14 phosphodiesterase 6A Homo sapiens 57-61 24271344-5 1976 Norepinephrine is more potent than dopamine in releasing PDEA from the particulate fraction of cerebellum, whereas dopamine is more active than norepinephrine in releasing PDEA from the particulate fraction of striatum. Norepinephrine 144-158 phosphodiesterase 6A Homo sapiens 172-176 933208-1 1976 The effect of the chronic administration of alpha-MSH on the incorporation of tritiated tyrosine into noradrenalin and dopamine and of tritiated tryptophan into serotonin was studied in different regions of the rat brain. Norepinephrine 102-114 proopiomelanocortin Rattus norvegicus 44-53 1265094-3 1976 In the present study driven atrial strips removed from stressed male CSF rats were found to exhibit an enhanced sensitivity to both norepinephrine and epinephrine. Norepinephrine 132-146 colony stimulating factor 2 Rattus norvegicus 69-72 1186497-1 1975 The effect of somatostatin, on the secretion of noradrenaline and adrenaline was studied in eight normal subjects during exercise and in insulin induced hypoglycemia. Norepinephrine 48-61 somatostatin Homo sapiens 14-26 1186497-3 1975 Plasma noradrenaline during exercise tended to be lower during the infusion of somatostatin but the difference was not significant. Norepinephrine 7-20 somatostatin Homo sapiens 79-91 805673-5 1975 Endogenous prostaglandin E-2 production contributes to the regulation of blood pressure by (1) opposing the vasoconstrictor and antidiuretic actions of circulating pressor hormones; (2) braking the release of norepinephrine from vasoconstrictor nerves; and (3) participating in the control extracellular fluid volume through its renal hemodynamic actions. Norepinephrine 209-223 cystatin 12, pseudogene Homo sapiens 25-28 165982-5 1975 On the one hand, insulin action (glucose transport) is inhibited by compounds (cholera toxin, ACTH, glucagon and L-norepinephrine) that stimulate adenylate cyclase; conversely, insulin both inhibits the lipolytic action of these compounds, and raises cellular levels of cyclic GMP. Norepinephrine 113-129 5'-nucleotidase, cytosolic II Homo sapiens 277-280 237167-0 1975 Inhibitory action of norepinephrine on the induction of tryptophan-2,3-dioxygenase by cortisol: mediation by the alpha-receptor. Norepinephrine 21-35 tryptophan 2,3-dioxygenase Homo sapiens 56-82 164437-2 1975 Adenosine deaminase markedly potentiated cyclic AMP accumulation due to norepinephrine. Norepinephrine 72-86 adenosine deaminase Rattus norvegicus 0-19 164437-14 1975 However, the addition of adenosine deaminase to fat cells incubated with 1.5 muM norepinephrine abolished the antilipolytic action of insulin and markedly reduced the increase in glucose oxidation due to insulin. Norepinephrine 81-95 adenosine deaminase Rattus norvegicus 25-44 1096294-0 1975 Effect of circulating norepinephrine on the renin release from the denervated kidney. Norepinephrine 22-36 renin Canis lupus familiaris 44-49 1096294-1 1975 The effect of renal denervation on the reactivity of the renin release mechanism to circulating norepinephrine was studied in six dogs with renal autografts. Norepinephrine 96-110 renin Canis lupus familiaris 57-62 1096294-3 1975 Both kidneys showed an increased release of renin when norepinephrine was given. Norepinephrine 55-69 renin Canis lupus familiaris 44-49 1096294-5 1975 Propranolol blocked the release of renin induced by norepinephrine without affecting either the reduced blood flow thorugh the autograft or the elevated blood pressure. Norepinephrine 52-66 renin Canis lupus familiaris 35-40 1096294-7 1975 The findings indicate that the renin release induced by circulating norepinephrine is independent of the intrarenal adrenergic nerves, and rather suggest that it is the result of an action of norepinephrine directly on the renin-producing juxtaglomerular cells. Norepinephrine 68-82 renin Canis lupus familiaris 31-36 1096294-7 1975 The findings indicate that the renin release induced by circulating norepinephrine is independent of the intrarenal adrenergic nerves, and rather suggest that it is the result of an action of norepinephrine directly on the renin-producing juxtaglomerular cells. Norepinephrine 192-206 renin Canis lupus familiaris 31-36 1096294-7 1975 The findings indicate that the renin release induced by circulating norepinephrine is independent of the intrarenal adrenergic nerves, and rather suggest that it is the result of an action of norepinephrine directly on the renin-producing juxtaglomerular cells. Norepinephrine 192-206 renin Canis lupus familiaris 223-228 4371328-0 1974 An ontogenic study on the effect of catecholamine receptor-stimulating agents on the turnover of noradrenaline and dopamine in the brain. Norepinephrine 97-110 adrenoceptor beta 2 Homo sapiens 36-58 4727451-5 1973 Release of insulin was strongly inhibited after epinephrine and norepinephrine, and strongly stimulated after isoproterenol. Norepinephrine 64-78 insulin Canis lupus familiaris 11-18 4727451-7 1973 Secretion of insulin remained unchanged after epinephrine and norepinephrine, but was stimulated by isoproterenol. Norepinephrine 62-76 insulin Canis lupus familiaris 13-20 4746448-0 1973 Influence of orphenadrine HC1 and its N-demethylated derivatives on the in vitro uptake of noradrenaline and 5-hydroxytryptamine by rat brain slices. Norepinephrine 91-104 Hypercalciuria QTL 1 Rattus norvegicus 26-29 5262991-0 1969 Brain norepinephrine: evidence that neuronal release is essential for sham rage behavior following brainstem transection in cat. Norepinephrine 6-20 long intergenic non-protein coding RNA 914 Homo sapiens 75-79 5262991-1 1969 There is a direct relationship between the magnitude of sham rage produced by brainstem transection in cat and the decrease of brainstem norepinephrine. Norepinephrine 137-151 long intergenic non-protein coding RNA 914 Homo sapiens 61-65 5262991-2 1969 The attacks of rage are augmented by protriptyline and inhibited by haloperidol, drugs respectively facilitating or depressing the action of norepinephrine centrally. Norepinephrine 141-155 long intergenic non-protein coding RNA 914 Homo sapiens 15-19 5256232-0 1969 Stimulation of C14-melatonin synthesis from C14-tryptophan by noradrenaline in rat pineal in organ culture. Norepinephrine 62-75 anti-Mullerian hormone receptor type 2 Rattus norvegicus 15-18 5256232-0 1969 Stimulation of C14-melatonin synthesis from C14-tryptophan by noradrenaline in rat pineal in organ culture. Norepinephrine 62-75 anti-Mullerian hormone receptor type 2 Rattus norvegicus 44-47 5642626-0 1968 [Analysis of the "biologic response" relationship for the action of oxytocin and noradrenaline on the skin and bladder of the frog]. Norepinephrine 81-94 oxytocin/neurophysin I prepropeptide Homo sapiens 68-76 17772081-1 1963 Infusion of angiotensin or renin in small quantities affects the sympathetic nervous system so that responses are increased to either drugs or reflexes that cause release of norepinephrine at nerve endings. Norepinephrine 174-188 renin Canis lupus familiaris 27-32 13030793-0 1953 Effect of tyrosinase upon the fluorimetric determination of epinephrine and arterenol. Norepinephrine 76-85 tyrosinase Homo sapiens 10-20 34053940-5 2021 A docking simulation using a triple reuptake inhibitor 8k and a serotonin/norepinephrine reuptake inhibitor 7j showed that the regions spanning transmembrane domain (TM)1, TM3, and TM6 form the ligand binding pocket. Norepinephrine 74-88 tropomyosin 3 Homo sapiens 172-175 33911125-2 2021 In this study, acute administration of the glucagon-like peptide-1 receptor agonist (GLP-1RA) liraglutide to mice increased the cecal levels of caseinolytic protease B, a component of Escherichia coli, and of norepinephrine. Norepinephrine 209-223 glucagon-like peptide 1 receptor Mus musculus 43-75 33915109-4 2021 Intravital two-photon imaging after injection of noradrenaline revealed transient inhibition of CD8+ and CD4+ T cell locomotion in tissues. Norepinephrine 49-62 CD8a molecule Homo sapiens 96-99 33871822-7 2021 We further showed that the catecholaminergic neurotransmitter norepinephrine exerted a pro-inflammatory function by enhancing the expression of IL-17 cytokines. Norepinephrine 62-76 interleukin 17A Homo sapiens 144-149 33917814-5 2021 Results showed increased hippocampal ROS and NOX2 levels, serotonin turnover, kynurenine, and noradrenaline contents in Abeta-treated rats. Norepinephrine 94-107 amyloid beta precursor protein Rattus norvegicus 120-125 33402011-7 2021 Remarkably, endogenous beta2-adrenergic receptor/ADRB2 dynamic mass redistribution functional responses to norepinephrine were significantly decreased following CHX treatment, with a time course equivalent to that observed with the SNAP-ADRB2 degradation assay. Norepinephrine 107-121 adrenoceptor beta 2 Homo sapiens 23-48 33402011-7 2021 Remarkably, endogenous beta2-adrenergic receptor/ADRB2 dynamic mass redistribution functional responses to norepinephrine were significantly decreased following CHX treatment, with a time course equivalent to that observed with the SNAP-ADRB2 degradation assay. Norepinephrine 107-121 adrenoceptor beta 2 Homo sapiens 49-54 33402011-7 2021 Remarkably, endogenous beta2-adrenergic receptor/ADRB2 dynamic mass redistribution functional responses to norepinephrine were significantly decreased following CHX treatment, with a time course equivalent to that observed with the SNAP-ADRB2 degradation assay. Norepinephrine 107-121 adrenoceptor beta 2 Homo sapiens 237-242 33855088-4 2021 Results: The norepinephrine levels were markedly high in gastric cancer tissue, while the norepinephrine-degrading enzymes MAOA and MAOB showed low expression. Norepinephrine 90-104 monoamine oxidase B Homo sapiens 132-136 33855088-8 2021 The norepinephrine-degrading enzymes MAOA and MAOB have significant expression differences in cancer and normal tissue, and their missing or low expression may predict immune therapy outcomes for gastric cancer patients. Norepinephrine 4-18 monoamine oxidase B Homo sapiens 46-50 33665818-0 2021 Downregulation of connexin43 potentiates noradrenaline-induced expression of brain-derived neurotrophic factor in primary cultured cortical astrocytes. Norepinephrine 41-54 brain derived neurotrophic factor Homo sapiens 77-110 33665818-8 2021 Knockdown of Cx43 potentiated noradrenaline (NA)-induced expression of BDNF mRNA in cultured astrocytes. Norepinephrine 30-43 brain derived neurotrophic factor Homo sapiens 71-75 33434145-8 2021 In vitro, 10 microM norepinephrine markedly downregulated the expressions of prolactin, IGFBP1, and PLZF, which are the specifical markers of decidual stromal cells during decidualization. Norepinephrine 20-34 prolactin Mus musculus 77-86 33451866-9 2021 The proportions of postoperative norepinephrine demand of patients carrying the AA genotype of ADRB2 rs1042713 (P = 0.016) and the AG genotype of COMT rs4680 (P = 0.018) were low. Norepinephrine 33-47 adrenoceptor beta 2 Homo sapiens 95-100 33551812-2 2020 Many of these are inhibitors of the presynaptic noradrenaline, dopamine, and serotonin transporters (NET, DAT, and SERT). Norepinephrine 48-61 solute carrier family 6 member 3 Homo sapiens 106-109 33430014-10 2021 Furthermore, Ang-(1-7) applied centrally restored mean arterial blood pressure (MABP) without affecting heart rate (HR) and prevented vascular hyporesponsiveness to norepinephrine (NE) and AVP in animals that received LPS. Norepinephrine 165-179 angiogenin Rattus norvegicus 13-21 33165197-8 2020 Our results suggest that norepinephrine activation of beta-adrenoceptors in the hippocampal dentate gyrus is involved in spatial learning and memory enhancement induced by CRS in aged rats, in part via modulations of synaptic efficiency and CREB-BDNF signaling pathway. Norepinephrine 25-39 brain-derived neurotrophic factor Rattus norvegicus 246-250 33075480-1 2020 The selective norepinephrine (NE) alpha2A-adrenoceptor (alpha2A-AR) agonist, guanfacine (Intuniv ), is FDA-approved for treating Attention Deficit Hyperactivity Disorder (ADHD) based on research in animals, a translational success story. Norepinephrine 14-28 adrenoceptor alpha 2A Homo sapiens 34-54 33075480-1 2020 The selective norepinephrine (NE) alpha2A-adrenoceptor (alpha2A-AR) agonist, guanfacine (Intuniv ), is FDA-approved for treating Attention Deficit Hyperactivity Disorder (ADHD) based on research in animals, a translational success story. Norepinephrine 14-28 adrenoceptor alpha 2A Homo sapiens 56-66 32668300-3 2020 We previously identified an essential role of the molecular scaffold 14-3-3zeta in adipogenesis, but one of the earliest, identified functions of 14-3-3zeta is its regulatory effects on the activity of tyrosine hydroxylase, the rate-limiting enzyme in the synthesis of norepinephrine. Norepinephrine 269-283 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide Mus musculus 146-156 32518084-0 2020 Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma. Norepinephrine 15-29 chemokine (C-C motif) ligand 2 Mus musculus 44-48 32232832-7 2020 Exendin-4 significantly relaxed the capillaries pre-contracted by noradrenaline, which was abolished by denuding endothelium with CHAPS and inhibited by GLP-1R antagonist exendin-9-39, endothelium nitric oxide synthase (eNOS) inhibitor L-NAME, and the guanylate cyclase blocker ODQ, but not by cyclooxygenase inhibitor indomethacin. Norepinephrine 66-79 glucagon-like peptide 1 receptor Rattus norvegicus 153-159 32232832-7 2020 Exendin-4 significantly relaxed the capillaries pre-contracted by noradrenaline, which was abolished by denuding endothelium with CHAPS and inhibited by GLP-1R antagonist exendin-9-39, endothelium nitric oxide synthase (eNOS) inhibitor L-NAME, and the guanylate cyclase blocker ODQ, but not by cyclooxygenase inhibitor indomethacin. Norepinephrine 66-79 nitric oxide synthase 3 Rattus norvegicus 185-218 32232832-7 2020 Exendin-4 significantly relaxed the capillaries pre-contracted by noradrenaline, which was abolished by denuding endothelium with CHAPS and inhibited by GLP-1R antagonist exendin-9-39, endothelium nitric oxide synthase (eNOS) inhibitor L-NAME, and the guanylate cyclase blocker ODQ, but not by cyclooxygenase inhibitor indomethacin. Norepinephrine 66-79 nitric oxide synthase 3 Rattus norvegicus 220-224 32335195-6 2020 Ang-(1-7) (0.3 nmol in 2 microL) promoted the release of splenic norepinephrine and attenuated tumor necrosis factor (TNF) and nitric oxide (NO), but increased interleukin-10 (IL-10), levels in the serum, spleen, and liver in endotoxemic rats. Norepinephrine 65-79 angiogenin Rattus norvegicus 0-8 32335195-11 2020 Together, our results indicate that Ang-(1-7) regulates systemic inflammation and vascular hyporesponsiveness in endotoxemia via activation of a central Mas receptors/sympathetic circuits/norepinephrine axis and provide novel mechanistic insights into the anti-inflammatory Ang-(1-7) properties. Norepinephrine 188-202 angiogenin Rattus norvegicus 36-44 32684737-19 2020 CONCLUSION: The inhibition of SGLT2 reduces the intermediate metabolite succinate, increases SCFA butyric acid levels and reduces norepinephrine content in mouse models of T1D. Norepinephrine 130-144 solute carrier family 5 (sodium/glucose cotransporter), member 2 Mus musculus 30-35 32084491-2 2020 VMAT2 is present in the membrane of secretory vesicles and transports dopamine (DA), norepinephrine (NE), serotonin (5-HT), histamine, glutamate (Glu), and GABA into vesicles for presynaptic release. Norepinephrine 85-99 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 0-5 31812551-4 2020 We found that Mdga1-KO mice exhibited statistically significant impairment of PPI, and had higher levels of homovanillic acid (HVA) in all three brain regions studied compared with Mdga1-HT and WT mice (P < 0.05), while levels of norepinephrine, DA and its metabolites 3,4-dihydroxyphenylacetic acid and 3-methoxytyramine remained unchanged. Norepinephrine 233-247 MAM domain containing glycosylphosphatidylinositol anchor 1 Mus musculus 14-19 31813250-8 2020 Suggesting a critical role of IL-17A in Paneth cell-mediated release of norepinephrine, recombinant IL-17A induces norepinephrine release in small intestine of mice. Norepinephrine 72-86 interleukin 17A Mus musculus 30-36 31813250-8 2020 Suggesting a critical role of IL-17A in Paneth cell-mediated release of norepinephrine, recombinant IL-17A induces norepinephrine release in small intestine of mice. Norepinephrine 72-86 interleukin 17A Mus musculus 100-106 31813250-8 2020 Suggesting a critical role of IL-17A in Paneth cell-mediated release of norepinephrine, recombinant IL-17A induces norepinephrine release in small intestine of mice. Norepinephrine 115-129 interleukin 17A Mus musculus 100-106 31297718-3 2019 The analysis of noradrenaline effects on brain cells demonstrates that it also regulates the production of the chemokine CCL2. Norepinephrine 16-29 chemokine (C-C motif) ligand 2 Mus musculus 121-125 31325464-0 2019 Sites phosphorylated in human alpha1B-adrenoceptors in response to noradrenaline and phorbol myristate acetate. Norepinephrine 67-80 alpha-1-B glycoprotein Homo sapiens 30-37 31356684-2 2019 The nuclear translocation of nuclear factor kappa-B (NFkappaB) homodimers, lacking transactivation domains, once induced by lipopolysaccharide (LPS) or tumor necrosis factor (TNF), inhibits the expression of Aanat gene and the synthesis of noradrenaline (NA)-induced melatonin. Norepinephrine 240-253 aralkylamine N-acetyltransferase Homo sapiens 208-213 31572182-6 2019 Here we report that, in vitro, activation of beta2-AR by norepinephrine and beta2-AR agonists promotes the formation of NPC-derived mature neurons, without affecting NPC survival or differentiation toward glial lineages. Norepinephrine 57-71 adrenoceptor beta 2 Homo sapiens 45-53 31151791-2 2019 We recently reported on a covalently binding noradrenaline analog (FAUC37) facilitating crystallization of the beta2-adrenergic receptor (beta2ARH2.64C) in an active state. Norepinephrine 45-58 adrenoceptor beta 2 Homo sapiens 111-136 31021732-2 2019 We have previously shown that the mandated housing temperature for laboratory mice (~22 C) induces mild, but chronic, cold stress resulting in increased circulating norepinephrine, which binds to, and triggers activation of, beta-adrenergic receptors (beta-AR) on tumor and immune cells. Norepinephrine 165-179 adrenergic receptor, beta 1 Mus musculus 225-250 31021732-2 2019 We have previously shown that the mandated housing temperature for laboratory mice (~22 C) induces mild, but chronic, cold stress resulting in increased circulating norepinephrine, which binds to, and triggers activation of, beta-adrenergic receptors (beta-AR) on tumor and immune cells. Norepinephrine 165-179 adrenergic receptor, beta 1 Mus musculus 252-259 30660754-12 2019 The effect of chronic MPH to increase levels of DAT, NET and VMAT2 suggests that the drug might long-term loose some of its acute action to increase extracellular levels of dopamine and noradrenaline. Norepinephrine 186-199 solute carrier family 18 member A2 Rattus norvegicus 61-66 30055194-4 2019 In contrast to NET, DAT and SERT, OCT3 has higher capacity and lower affinity for substrates, is sodium-independent, and is multi-specific, with the capacity to transport norepinephrine, dopamine, serotonin and histamine. Norepinephrine 171-185 solute carrier family 6 member 3 Homo sapiens 20-23 30055194-4 2019 In contrast to NET, DAT and SERT, OCT3 has higher capacity and lower affinity for substrates, is sodium-independent, and is multi-specific, with the capacity to transport norepinephrine, dopamine, serotonin and histamine. Norepinephrine 171-185 OCTN3 Homo sapiens 34-38 31503242-2 2019 On smooth muscle cells of pulmonary vessels there are postsynaptic alpha1A-, alpha1B-, alpha1D- and alpha2A-, alpha2B-, alpha2C-adrenoreceptors whose activation by norepinephrine induces vasoconstriction. Norepinephrine 164-178 calcium voltage-gated channel subunit alpha1 A Homo sapiens 67-74 31061315-0 2019 Noradrenaline-Induced Relaxation of Urinary Bladder Smooth Muscle Is Primarily Triggered through the beta3-Adrenoceptor in Rats. Norepinephrine 0-13 adrenoceptor beta 3 Rattus norvegicus 101-119 31061315-9 2019 In the presence of propranolol (10-6 M), noradrenaline-induced relaxation was competitively inhibited by bupranolol (3 x 10-7-3 x 10-6 M) or SR59230A (10-7-10-6 M; selective beta3-adrenoceptor antagonist), with their pA2 values calculated to be 6.64 and 7.27, respectively. Norepinephrine 41-54 adrenoceptor beta 3 Rattus norvegicus 174-192 30571558-3 2019 Application of norepinephrine increased the basolateral 40 pS K+ channel (Kir4.1/Kir5.1 heterotetramer) in the DCT. Norepinephrine 15-29 potassium inwardly-rectifying channel, subfamily J, member 16 Mus musculus 81-87 30253326-4 2019 beta2-adrenergic receptors are much more sensitive to epinephrine than to norepinephrine. Norepinephrine 74-88 hemoglobin, beta adult minor chain Mus musculus 0-5 29476941-0 2018 Postoperative serum levels of Endocan are associated with the duration of norepinephrine support after coronary artery bypass surgery. Norepinephrine 74-88 endothelial cell specific molecule 1 Homo sapiens 30-37 29476941-12 2018 The norepinephrine support increases the risk of Endocan release, suggesting a relationship between the kinetic of Endocan and the vasoplegic syndrome. Norepinephrine 4-18 endothelial cell specific molecule 1 Homo sapiens 49-56 29476941-12 2018 The norepinephrine support increases the risk of Endocan release, suggesting a relationship between the kinetic of Endocan and the vasoplegic syndrome. Norepinephrine 4-18 endothelial cell specific molecule 1 Homo sapiens 115-122 29501506-9 2018 In this article, we review the effects of G-protein coupled receptors (GPCR) and neuromodulators, including acetylcholine, noradrenalin, serotonin and dopamine, on working memory and TRPC channels. Norepinephrine 123-135 vomeronasal 1 receptor 17 pseudogene Homo sapiens 42-69 30209240-5 2018 Both CNTF and secretagogin ablation occlude stress-induced cortical norepinephrine synthesis, ensuing neuronal excitation and behavioral stereotypes. Norepinephrine 68-82 ciliary neurotrophic factor Homo sapiens 5-9 30007012-1 2018 BACKGROUND AND PURPOSE: We have demonstrated that i.c.v.-administered (+-)-epibatidine, a nicotinic ACh receptor (nAChR) agonist, induced secretion of noradrenaline and adrenaline (catecholamines) from the rat adrenal medulla with dihydro-beta-erythroidin (an alpha4beta2 nAChR antagonist)-sensitive brain mechanisms. Norepinephrine 151-164 cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus 90-112 30007012-1 2018 BACKGROUND AND PURPOSE: We have demonstrated that i.c.v.-administered (+-)-epibatidine, a nicotinic ACh receptor (nAChR) agonist, induced secretion of noradrenaline and adrenaline (catecholamines) from the rat adrenal medulla with dihydro-beta-erythroidin (an alpha4beta2 nAChR antagonist)-sensitive brain mechanisms. Norepinephrine 151-164 cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus 114-119 30007012-1 2018 BACKGROUND AND PURPOSE: We have demonstrated that i.c.v.-administered (+-)-epibatidine, a nicotinic ACh receptor (nAChR) agonist, induced secretion of noradrenaline and adrenaline (catecholamines) from the rat adrenal medulla with dihydro-beta-erythroidin (an alpha4beta2 nAChR antagonist)-sensitive brain mechanisms. Norepinephrine 151-164 cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus 272-277 30037827-8 2018 The spatial structure of both fluctuation patterns resembled the spatial distribution of the expression of catecholamine receptor genes: alpha1 norepinephrine receptors (for the fluctuation pattern: placebo > atomoxetine), D2-like dopamine receptors (pattern: atomoxetine > placebo), and beta norepinephrine receptors (for both patterns, with correlations of opposite sign). Norepinephrine 144-158 adrenoceptor beta 2 Homo sapiens 107-129 30037827-8 2018 The spatial structure of both fluctuation patterns resembled the spatial distribution of the expression of catecholamine receptor genes: alpha1 norepinephrine receptors (for the fluctuation pattern: placebo > atomoxetine), D2-like dopamine receptors (pattern: atomoxetine > placebo), and beta norepinephrine receptors (for both patterns, with correlations of opposite sign). Norepinephrine 293-307 adrenoceptor beta 2 Homo sapiens 107-129 30139713-5 2018 The alpha1A- and alpha1D-adrenoceptor antagonist tamsulosin antagonized noradrenaline responses with high affinity (pKD = 9.7 +- 0.3), whilst BMY7378 (100 nM) (alpha1D-adrenoceptor antagonist) failed to antagonize responses. Norepinephrine 72-85 calcium voltage-gated channel subunit alpha1 A Homo sapiens 4-11 29377263-0 2018 The alpha1-adrenergic receptor is involved in hepcidin upregulation induced by adrenaline and norepinephrine via the STAT3 pathway. Norepinephrine 94-108 hepcidin antimicrobial peptide Mus musculus 46-54 29555480-7 2018 Moreover, we also found that CORT levels in serum were significantly increased, along with the decrease of brain-derived neurotrophic factor (BDNF) mRNA, BDNF protein, 5-hydroxytryptamine (5-HT) and norepinephrine (NE) levels in the hippocampus. Norepinephrine 199-213 cortistatin Mus musculus 29-33 29720569-2 2018 We tested whether phosphodiesterase 2A (PDE2A), which regulates the action of BNP-activated cyclic guanosine monophosphate (cGMP), was directly involved in modulating Ca2+ handling from stellate ganglia (SG) neurons and cardiac norepinephrine (NE) release in rats and humans with an enhanced sympathetic phenotype. Norepinephrine 228-242 phosphodiesterase 2A Rattus norvegicus 18-38 29720569-2 2018 We tested whether phosphodiesterase 2A (PDE2A), which regulates the action of BNP-activated cyclic guanosine monophosphate (cGMP), was directly involved in modulating Ca2+ handling from stellate ganglia (SG) neurons and cardiac norepinephrine (NE) release in rats and humans with an enhanced sympathetic phenotype. Norepinephrine 228-242 phosphodiesterase 2A Rattus norvegicus 40-45 29552556-1 2018 Monoamine oxidase B (MAO-B) catalyzes deamination of monoamines such as neurotransmitters dopamine and norepinephrine. Norepinephrine 103-117 monoamine oxidase B Homo sapiens 0-19 29552556-1 2018 Monoamine oxidase B (MAO-B) catalyzes deamination of monoamines such as neurotransmitters dopamine and norepinephrine. Norepinephrine 103-117 monoamine oxidase B Homo sapiens 21-26 28549109-7 2018 Indeed, a positive correlation was observed between the serum levels of norepinephrine and IL-18 in patients with chest pain. Norepinephrine 72-86 interleukin 18 Homo sapiens 91-96 28983964-1 2018 Expression of brain-derived neurotrophic factor (BDNF) is induced in cultured rat cortical astrocytes by catecholamines norepinephrine and dopamine as well as selective alpha1 and beta adrenergic agonists. Norepinephrine 120-134 brain-derived neurotrophic factor Rattus norvegicus 14-47 28983964-1 2018 Expression of brain-derived neurotrophic factor (BDNF) is induced in cultured rat cortical astrocytes by catecholamines norepinephrine and dopamine as well as selective alpha1 and beta adrenergic agonists. Norepinephrine 120-134 brain-derived neurotrophic factor Rattus norvegicus 49-53 28983964-4 2018 We show that in cortical astrocytes BDNF exon IV and exon VI containing mRNAs are induced by dopamine and norepinephrine via CREB-dependent signaling and that this regulation is mediated by a mechanism that is distinct from activity-dependent CREB-mediated activation of BDNF transcription in neurons. Norepinephrine 106-120 brain-derived neurotrophic factor Rattus norvegicus 36-40 28983964-4 2018 We show that in cortical astrocytes BDNF exon IV and exon VI containing mRNAs are induced by dopamine and norepinephrine via CREB-dependent signaling and that this regulation is mediated by a mechanism that is distinct from activity-dependent CREB-mediated activation of BDNF transcription in neurons. Norepinephrine 106-120 brain-derived neurotrophic factor Rattus norvegicus 271-275 29318546-3 2018 We here describe detailed methodology for the detection of pro- and active- forms of both MMP-2 (gelatinase A) and MMP-9 (gelatinase B) in cells using norepinephrine-stimulated H9c2 cardiomyoblasts as model. Norepinephrine 151-165 matrix metallopeptidase 9 Homo sapiens 115-120 29247240-3 2017 Using genetic and RNA interference approaches, we show that the activity of the Oamb gene, which encodes a receptor for octopamine (OA, the invertebrate homologue of norepinephrine), plays a major role in controlled sugar consumption. Norepinephrine 166-180 Octopamine receptor in mushroom bodies Drosophila melanogaster 80-84 28888989-0 2017 Noradrenaline, oxymetazoline and phorbol myristate acetate induce distinct functional actions and phosphorylation patterns of alpha1A-adrenergic receptors. Norepinephrine 0-13 calcium voltage-gated channel subunit alpha1 A Homo sapiens 126-133 29472953-1 2017 Objective: Several studies have shown that some polymorphisms of genes encoding catechol-O-methyltransferase (COMT), the key enzyme in degrading dopamine, and norepinephrine and the human brain-derived neurotropic factor (BDNF), a nerve growth factor, are strong candidates for risk of schizophrenia (SCZ). Norepinephrine 159-173 brain derived neurotrophic factor Homo sapiens 222-226 27836486-1 2017 Vesicular monoamine transporter 2 (VMAT2, SLC18A2) is a transmembrane transporter protein that packages dopamine, serotonin, norepinephrine, and histamine into vesicles in preparation for neurotransmitter release from the presynaptic neuron. Norepinephrine 125-139 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 35-40 27836486-1 2017 Vesicular monoamine transporter 2 (VMAT2, SLC18A2) is a transmembrane transporter protein that packages dopamine, serotonin, norepinephrine, and histamine into vesicles in preparation for neurotransmitter release from the presynaptic neuron. Norepinephrine 125-139 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 42-49 28835457-5 2017 Noradrenaline and adrenaline dose-dependently suppressed the release of IL-27p28 in LPS/TLR4-activated macrophages, which was independent of alpha1 adrenoceptors. Norepinephrine 0-13 interleukin 27 Mus musculus 72-80 28663279-1 2017 The alpha-like octopamine receptors (OctR) are believed to be the evolutionary precursor to the vertebrate alpha2-adrenergic receptors (alpha2-ARs) based upon sequence similarity and the ability to interact with norepinephrine and a number of compounds that bind with high affinity to alpha2-ARs. Norepinephrine 212-226 nicotinic Acetylcholine Receptor alpha1 Drosophila melanogaster 4-14 28855875-4 2017 Both alpha2C- and alpha2A-AR share autoreceptor functions to exert negative feedback control on noradrenaline (NA) release, with alpha2C-AR heteroreceptors regulating non-noradrenergic transmission (e.g., serotonin, dopamine). Norepinephrine 96-109 adrenoceptor alpha 2A Homo sapiens 18-28 28458039-1 2017 Dexamethaone (DEX, glucocorticoid receptor agonist) and RU486 (glucocorticoid receptor inhibitor) may affect the behavior of attention deficit hyperactivity disorder (ADHD) rats, by changing the level of dopamine and noradrenaline and dopamine transporter in different regions of their brain. Norepinephrine 217-230 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 19-42 28458039-1 2017 Dexamethaone (DEX, glucocorticoid receptor agonist) and RU486 (glucocorticoid receptor inhibitor) may affect the behavior of attention deficit hyperactivity disorder (ADHD) rats, by changing the level of dopamine and noradrenaline and dopamine transporter in different regions of their brain. Norepinephrine 217-230 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 63-86 28473352-0 2017 miR-21 is involved in norepinephrine-mediated rat granulosa cell apoptosis by targeting SMAD7. Norepinephrine 22-36 microRNA 21 Rattus norvegicus 0-6 28865224-3 2017 The aim of this study was to investigate adrenal medulla activity in vitro depending, on a dose of CRH, AVP and OXY on adrenaline and noradrenaline release. Norepinephrine 134-147 corticoliberin Ovis aries 99-102 28865224-3 2017 The aim of this study was to investigate adrenal medulla activity in vitro depending, on a dose of CRH, AVP and OXY on adrenaline and noradrenaline release. Norepinephrine 134-147 vasopressin-neurophysin 2-copeptin Ovis aries 104-107 28865224-5 2017 The results showed that CRH stimulates adrenaline and noradrenaline release from the adrenal medulla tissue. Norepinephrine 54-67 corticoliberin Ovis aries 24-27 28865224-6 2017 The stimulating influence of AVP on adrenaline release was visible after the application of the two lower doses of this neuropeptide; however, AVP reduced noradrenaline release from the adrenal medulla tissue. Norepinephrine 155-168 vasopressin-neurophysin 2-copeptin Ovis aries 143-146 28848192-9 2017 In vitro activation of splenocytes isolated from immunized mice with agonists targeting TLR2 and NOD2 together with beta2-adrenergic activation (induced by epinephrine, norepinephrine, or salbutamol) resulted in decreased IFN-gamma but increased IL-17 immune responses. Norepinephrine 169-183 hemoglobin, beta adult minor chain Mus musculus 116-121 28848192-10 2017 The beta2-adrenergic antagonist propranolol could restore IFN-gamma production, whereas only the norepinephrine-induced increase in IL-17 production was abrogated. Norepinephrine 97-111 interleukin 17A Mus musculus 132-137 27647372-5 2016 The provided SAR data and potent biological activity can offer useful guidelines for designing dual norepinephrine and dopamine reuptake inhibitors as effective therapeutic agents for treatment of several central nervous system diseases. Norepinephrine 100-114 sarcosine dehydrogenase Homo sapiens 13-16 27325446-2 2016 Here, we describe our medicinal chemistry approach to discover a novel series of highly potent, peripheral-selective, and orally available noradrenaline reuptake inhibitors with a low multidrug resistance protein 1 (MDR1) efflux ratio by cyclization of an amide moiety and introduction of an acidic group. Norepinephrine 139-152 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 184-214 27325446-2 2016 Here, we describe our medicinal chemistry approach to discover a novel series of highly potent, peripheral-selective, and orally available noradrenaline reuptake inhibitors with a low multidrug resistance protein 1 (MDR1) efflux ratio by cyclization of an amide moiety and introduction of an acidic group. Norepinephrine 139-152 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 216-220 27372867-5 2016 Changes in microcirculatory flow, by altering the flow mediated effect of plasma noradrenaline, are mainly responsible for altering the noradrenergic balance in the peripheral tissues; changes in CSF flow are speculated to be mainly responsible for doing the same in the brain, by altering the balance between synaptic noradrenaline in the brain and nonsynaptic noradrenaline in the subarachnoid CSF. Norepinephrine 319-332 colony stimulating factor 2 Canis lupus familiaris 196-199 27372867-5 2016 Changes in microcirculatory flow, by altering the flow mediated effect of plasma noradrenaline, are mainly responsible for altering the noradrenergic balance in the peripheral tissues; changes in CSF flow are speculated to be mainly responsible for doing the same in the brain, by altering the balance between synaptic noradrenaline in the brain and nonsynaptic noradrenaline in the subarachnoid CSF. Norepinephrine 319-332 colony stimulating factor 2 Canis lupus familiaris 196-199 27376152-5 2016 ADRA2A is the main presynaptic inhibitory feedback G protein-coupled receptor regulating norepinephrine release. Norepinephrine 89-103 adrenoceptor alpha 2A Homo sapiens 0-6 27378937-11 2016 Melanocortin 4 receptor mRNA levels were increased in the brains of both uDNX and UniNX compared to Sham and may contribute to increased tissue noradrenaline levels. Norepinephrine 144-157 melanocortin 4 receptor Rattus norvegicus 0-23 27190169-6 2016 Inasmuch as they increase synaptic dopamine levels, dopamine transporter (DAT) inhibitors, whether they are selective or have actions on noradrenaline or serotonin transporters, theoretically represent an attractive way to alleviate parkinsonism per se and potentially enhance l-DOPA antiparkinsonian action (provided that sufficient dopamine terminals remain within the striatum). Norepinephrine 137-150 solute carrier family 6 member 3 Homo sapiens 52-72 27190169-6 2016 Inasmuch as they increase synaptic dopamine levels, dopamine transporter (DAT) inhibitors, whether they are selective or have actions on noradrenaline or serotonin transporters, theoretically represent an attractive way to alleviate parkinsonism per se and potentially enhance l-DOPA antiparkinsonian action (provided that sufficient dopamine terminals remain within the striatum). Norepinephrine 137-150 solute carrier family 6 member 3 Homo sapiens 74-77 26801076-5 2016 In addition, a negative P2XR/nAChR cross-talk was observed in the control of the evoked release of noradrenaline from rat hippocampal synaptosomes, characterized by a less-than-additive facilitatory effect upon co-activation of both receptors. Norepinephrine 99-112 cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus 29-34 26257064-4 2016 Increased metabolites, PTGS2 and PTGES protein levels were found in Skov3-ip1 and HeyA8 cells treated with norepinephrine (NE), and these changes were shown to be mediated by ADRB2 receptor signaling. Norepinephrine 107-121 prostaglandin E synthase Homo sapiens 33-38 26257064-4 2016 Increased metabolites, PTGS2 and PTGES protein levels were found in Skov3-ip1 and HeyA8 cells treated with norepinephrine (NE), and these changes were shown to be mediated by ADRB2 receptor signaling. Norepinephrine 107-121 adrenoceptor beta 2 Homo sapiens 175-180 26572541-1 2016 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of catecholamines and TH immunoreactivity is indicative of cells synthesising either adrenaline/noradrenaline or dopamine. Norepinephrine 167-180 tyrosine hydroxylase Danio rerio 0-20 26572541-1 2016 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of catecholamines and TH immunoreactivity is indicative of cells synthesising either adrenaline/noradrenaline or dopamine. Norepinephrine 167-180 tyrosine hydroxylase Danio rerio 93-95 26572539-4 2016 Adrenomedullary content of the secreted adrenal catecholamines norepinephrine (NE) and epinephrine (EPI) was decreased 30-40 % in Chga-KO mice. Norepinephrine 63-77 chromogranin A Mus musculus 130-134 26604136-8 2016 beta-adrenergic stress induced with 10 microm norepinephrine demonstrated increased susceptibility to sarcomeric disorganization (RBM20: 86 +- 10.5% versus control: 40 +- 7%; P < 0.001). Norepinephrine 46-60 RNA binding motif protein 20 Homo sapiens 130-135 26393369-1 2015 The isozymes of monoamine oxidase (MAO-A and MAO-B) are important enzymes involved in the metabolism of numerous biogenic amines, including the neurotransmitters serotonin, dopamine, and norepinephrine. Norepinephrine 187-201 monoamine oxidase B Rattus norvegicus 45-50 26189762-5 2015 The inhibitory effect of ONO-2952 on stress-induced noradrenaline release was attenuated by co-treatment with the TSPO agonist CB34 in a dose-dependent manner. Norepinephrine 52-65 translocator protein Rattus norvegicus 114-118 26321956-4 2015 In human neutrophils, adrenaline and noradrenaline inhibit migration, CD11b/CD18 expression, and oxidative metabolism, possibly through beta-AR, although the role of alpha1- and alpha2-AR requires further investigation. Norepinephrine 37-50 integrin subunit alpha M Homo sapiens 70-75 26321956-4 2015 In human neutrophils, adrenaline and noradrenaline inhibit migration, CD11b/CD18 expression, and oxidative metabolism, possibly through beta-AR, although the role of alpha1- and alpha2-AR requires further investigation. Norepinephrine 37-50 adrenergic receptor, beta 1 Mus musculus 136-143 26058426-6 2015 Mice treated with norepinephrine, displayed an increased number of metastatic foci of DU145 cells in inguinal lymph nodes and also showed an increased expression of MMP2 and MMP9 in tumor samples compared to controls. Norepinephrine 18-32 matrix metallopeptidase 9 Homo sapiens 174-178 25728347-10 2015 Propranolol inhibited norepinephrine-induced cell invasion by reducing the expression of MMP-9, VEGF, and p-cofilin. Norepinephrine 22-36 matrix metallopeptidase 9 Homo sapiens 89-94 25728347-11 2015 NO and VEGF release induced by norepinephrine was decreased by propranolol pretreatment, coincident with alterations in the phosphorylation of Akt, eNOS, and VEGFR-2. Norepinephrine 31-45 kinase insert domain receptor Homo sapiens 158-165 25916729-9 2015 In addition, Ad.PRSx8-mCherry/CAPON also reduced (3)H-norepinephrine release from spontaneously hypertensive rat atria (n=7). Norepinephrine 54-68 nitric oxide synthase 1 adaptor protein Rattus norvegicus 30-35 25912576-0 2015 Norepinephrine attenuates CXCR4 expression and the corresponding invasion of MDA-MB-231 breast cancer cells via beta2-adrenergic receptors. Norepinephrine 0-14 C-X-C motif chemokine receptor 4 Homo sapiens 26-31 25912576-6 2015 The CXCR4 gene demonstrated the greatest response to norepinephrine treatment, with a reduction of transcription of 95.7%, and was the focus of subsequent investigations. Norepinephrine 53-67 C-X-C motif chemokine receptor 4 Homo sapiens 4-9 25912576-7 2015 Real-time reverse transcription-PCR was used to determine the level of CXCR4 transcription after treatment with norepinephrine at various concentrations and for different durations. Norepinephrine 112-126 C-X-C motif chemokine receptor 4 Homo sapiens 71-76 25912576-8 2015 RESULTS: The results revealed that norepinephrine reduced CXCR4 transcription in a dose-dependent manner. Norepinephrine 35-49 C-X-C motif chemokine receptor 4 Homo sapiens 58-63 25912576-9 2015 Norepinephrine was also found to exert a negative effect on CXCR4 translational expression, as evidenced by a 44 +- 1.7% reduction in expression after a 12-h treatment with 10 microM norepinephrine. Norepinephrine 0-14 C-X-C motif chemokine receptor 4 Homo sapiens 60-65 25912576-9 2015 Norepinephrine was also found to exert a negative effect on CXCR4 translational expression, as evidenced by a 44 +- 1.7% reduction in expression after a 12-h treatment with 10 microM norepinephrine. Norepinephrine 183-197 C-X-C motif chemokine receptor 4 Homo sapiens 60-65 25912576-11 2015 Finally, we found the specific beta2-adrenergic antagonist, ICI 118,551, eliminated the impact of norepinephrine on CXCR4 expression. Norepinephrine 98-112 C-X-C motif chemokine receptor 4 Homo sapiens 116-121 25912576-12 2015 CONCLUSIONS: Norepinephrine attenuates CXCR4 expression and the corresponding invasion of MDA-MB-231 tumor cells via the beta2-adrenergic receptor. Norepinephrine 13-27 C-X-C motif chemokine receptor 4 Homo sapiens 39-44 25912576-12 2015 CONCLUSIONS: Norepinephrine attenuates CXCR4 expression and the corresponding invasion of MDA-MB-231 tumor cells via the beta2-adrenergic receptor. Norepinephrine 13-27 adrenoceptor beta 2 Homo sapiens 121-146 25799564-9 2015 It was observed that when alpha1B-adrenergic receptors were stimulated with noradrenaline, the receptors interacted with proteins present in early endosomes, such as the early endosomes antigen 1, Rab 5, Rab 4, and Rab 11 but not with late endosome markers, such as Rab 9 and Rab 7. Norepinephrine 76-89 RAB9A, member RAS oncogene family Homo sapiens 266-271 25824473-2 2015 In contrast, ADRB-2 expression and function in nonhuman primate and human ovary were not fully known but innervation and significant levels of norepinephrine (NE), which is a ligand at the ADRB-2, were reported in the ovary. Norepinephrine 143-157 adrenoceptor beta 2 Homo sapiens 189-195 25448824-1 2015 5-HT2c G-protein coupled receptors located in the central nervous system bind the endogenous neurotransmitters serotonin and couple to G protein to mediate excitatory neurotransmission, which inhibits dopamine and norepinephrine release in the brain. Norepinephrine 214-228 5-hydroxytryptamine receptor 2C Rattus norvegicus 0-6 25569089-3 2015 Blockade of 5-HT2c receptors causes release of both noradrenaline and dopamine at the fronto-cortical dopaminergic and noradrenergic pathways. Norepinephrine 52-65 5-hydroxytryptamine receptor 2C Homo sapiens 12-18 25433327-2 2015 Peptidomic analysis of host-defense peptides in norepinephrine-stimulated skin secretions from frogs from the Cape Peninsula range resulted in the identification of two magainins, two peptide glycine-leucine-amide (PGLa) peptides, two xenopsin-precursor fragment (XPF) peptides, nine caerulein-precursor fragment (CPF) peptides, and a peptide related to peptide glycine-glutamine (PGQ) previously found in an extract of Xenopus laevis stomach. Norepinephrine 48-62 prepro-PGLa S homeolog Xenopus laevis 215-219 25566095-6 2014 beta3-adrenoceptor agonist (BRL37344) reduced baseline vascular resistance, the tyramine-stimulated norepinephrine overflow and the positive inotropic response to tyramine in hypertensive but not normotensive rats. Norepinephrine 100-114 adrenoceptor beta 3 Rattus norvegicus 0-18 25566095-7 2014 beta3-adrenoceptor antagonist (SR59230A) reduced tyramine-stimulated norepinephrine release in both strains and the secretion of epinephrine in hypertensive rats. Norepinephrine 69-83 adrenoceptor beta 3 Rattus norvegicus 0-18 25549103-5 2014 After the memory reactivation we administer an oral dose of 40 mg of propranolol HCl, a beta-adrenergic receptor antagonist that indirectly targets the protein synthesis required for reconsolidation by inhibiting the noradrenaline-stimulated CREB phosphorylation. Norepinephrine 217-230 cAMP responsive element binding protein 1 Homo sapiens 242-246 25218306-0 2014 VEGF-induced antidepressant effects involve modulation of norepinephrine and serotonin systems. Norepinephrine 58-72 vascular endothelial growth factor A Mus musculus 0-4 25218306-7 2014 However, we found imbalances in brain monoamine contents, in which the levels of norepinephrine and serotonin, but not dopamine, were decreased exclusively in the regions where VEGF was expressed. Norepinephrine 81-95 vascular endothelial growth factor A Mus musculus 177-181 25218306-12 2014 These data suggest that VEGF-induced antidepressant-like effects involve modulation of norepinephrine and serotonin systems. Norepinephrine 87-101 vascular endothelial growth factor A Mus musculus 24-28 25132576-2 2014 However, previous findings on the association between aggregated sAA and other sympathetic markers, namely norepinephrine and epinephrine, were mixed. Norepinephrine 107-121 amylase alpha 1A Homo sapiens 65-68 25087915-9 2014 Targeting of brain MC4R is a promising strategy to protect HPA axis, LC-NE (locus coeruleus-norepinephrine) systems and hippocampus from overstimulation. Norepinephrine 92-106 melanocortin 4 receptor Rattus norvegicus 19-23 25355210-9 2014 Collectively, these results indicate that chronic restraint stress impairs the alpha1-AR LTD by reducing the function of presynaptic CB1 receptors and reveal a novel mechanism by which noradrenaline controls synaptic strength and plasticity in the DRn. Norepinephrine 185-198 cannabinoid receptor 1 Rattus norvegicus 133-136 25131562-2 2014 Previous studies have shown that, in the rat medial prefrontal cortex (mPFC), CB1R agonists increase norepinephrine release, an effect that may be attributed, in part, to CB1Rs localised to noradrenergic axon terminals. Norepinephrine 101-115 cannabinoid receptor 1 Rattus norvegicus 78-81 24995933-12 2014 Chronic infusion of apelin-13 into the PVN in normotensive rats induced hypertension, increased plasma noradrenaline and AVP levels and promoted myocardial atrial natriuretic peptide and beta-myosin heavy chain mRNA expressions, two indicative markers of cardiac hypertrophy. Norepinephrine 103-116 apelin Rattus norvegicus 20-26 24553734-2 2014 We found that microinfusion of norepinephrine (NE) into the CA1 area of the dorsal hippocampus during the early phase (0 h) after extinction enhanced extinction LTM at 2 and 14 days after extinction. Norepinephrine 31-45 carbonic anhydrase 1 Homo sapiens 60-63 24440144-0 2014 The sympathetic nervous system modulates CD4(+)Foxp3(+) regulatory T cells via noradrenaline-dependent apoptosis in a murine model of lymphoproliferative disease. Norepinephrine 79-92 CD4 antigen Mus musculus 41-44 24748481-2 2014 To explore this possibility, we assessed the treatment effects of desipramine and citalopram, which inhibit the reuptake of norepinephrine and serotonin into the presynaptic terminals, respectively, on changes in levels of CART-IR before and after the test swim in mouse brain. Norepinephrine 124-138 CART prepropeptide Mus musculus 223-227 24554716-7 2014 Clinical research also shows that serum GDF-15 levels in hypertensive patients were significant higher than in healthy volunteers and were positively correlated with the thickness of the posterior wall of the left ventricle, interventricular septum, and left ventricular mass, as well as the serum level of norepinephrine. Norepinephrine 307-321 growth differentiation factor 15 Homo sapiens 40-46 24362581-7 2014 Tumors arising in patients with mutations of the SDHB gene have at least a 30 % chance of metastasizing and typically produce norepinephrine and/or dopamine. Norepinephrine 126-140 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 49-53 24231511-9 2014 Brain Ang (1-7) administration profoundly modified responses to stress, indicated by altered levels of several stress hormones, including Ang II, glucocorticoid, norepinephrine, serotonin, and dopamine, in blood or stress-related brain regions. Norepinephrine 162-176 angiogenin Rattus norvegicus 6-9 24295263-7 2013 The contraction induced by norepinephrine was reversed by the drugs with the following rank order of efficacy: sodium nitroprusside > delquamine > sildenafil > C-type natriuretic peptide > forskolin > acetylcholine. Norepinephrine 27-41 natriuretic peptide C Homo sapiens 169-195 24072708-9 2013 Indicative of a direct regulatory role for Them2 in heat production, cultured primary brown adipocytes from Them2(-/-) mice exhibited increased norepinephrine-mediated triglyceride hydrolysis and increased rates of O2 consumption, together with elevated expression of thermogenic genes. Norepinephrine 144-158 acyl-CoA thioesterase 13 Mus musculus 108-113 23333670-0 2013 c-Fos activity mapping reveals differential effects of noradrenaline and serotonin depletion on the regulation of ocular dominance plasticity in rats. Norepinephrine 55-68 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-5 23333670-3 2013 Applying this new method, here we studied the unique modification of the degree of c-Fos expression induced in the visual cortex, in that endogenous noradrenaline (NA) and serotonin (5HT) in the cortex were significantly reduced, respectively by specific pharmacological agents. Norepinephrine 149-162 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 83-88 23364786-0 2013 Differential phosphorylation, desensitization, and internalization of alpha1A-adrenoceptors activated by norepinephrine and oxymetazoline. Norepinephrine 105-119 calcium voltage-gated channel subunit alpha1 A Homo sapiens 70-77 23364786-3 2013 It is well established that alpha1A-ARs are less phosphorylated, desensitized, and internalized on exposure to the phenethylamines norepinephrine (NE), epinephrine, or phenylephrine (PE) than are the alpha1B and alpha1D subtypes. Norepinephrine 131-145 calcium voltage-gated channel subunit alpha1 A Homo sapiens 28-35 23421681-4 2013 The 6-position of serotonin and the para-hydroxyl groups of dopamine and norepinephrine were found to face Ala173 in hSERT, Gly153 in hDAT, and Gly149 in hNET. Norepinephrine 73-87 solute carrier family 6 member 3 Homo sapiens 134-138 23421681-7 2013 Uptake experiments support that the 5-hydroxyl group of serotonin and the meta-hydroxyl group norepinephrine and dopamine are placed in the hydrophilic pocket around Ala173, Ser438, and Thr439 in hSERT corresponding to Gly149, Ser419, Ser420 in hNET and Gly153 Ser422 and Ala423 in hDAT. Norepinephrine 94-108 solute carrier family 6 member 3 Homo sapiens 282-286 23469282-8 2013 HDAC10 expression was found in AgRP neurons, POMC neurons, dopamine neurons and noradrenaline neurons but not in other neuronal groups. Norepinephrine 80-93 histone deacetylase 10 Homo sapiens 0-6 21898033-6 2012 The present study aims to examine the association between three common BDNF single-nucleotid polymorphisms (SNPs; rs7103411, rs7124442, and rs6265) and depressive symptoms in a community-based elderly population taking into account the serum levels of four neurotransmitters, serotonin, dopamine, adrenalin, and noradrenalin, as potential mediating factors. Norepinephrine 312-324 brain derived neurotrophic factor Homo sapiens 71-75 22954623-0 2012 Acute stress responses in salivary alpha-amylase predict increases of plasma norepinephrine. Norepinephrine 77-91 amylase alpha 1A Homo sapiens 26-48 22834682-3 2012 Furthermore, [Dmt(1) ]DALDA inhibits norepinephrine re-uptake and is a mitochondria-targeted antioxidant. Norepinephrine 37-51 RoBo-1 Rattus norvegicus 14-20 22865387-12 2012 Interestingly, the heart of P2Y(4)-null mice displayed a reduced sympathetic innervation associated with a decreased norepinephrine level. Norepinephrine 117-131 pyrimidinergic receptor P2Y, G-protein coupled, 4 Mus musculus 28-34 22454242-3 2012 We hypothesized that DAOA polymorphisms are associated with dopamine, serotonin and noradrenaline turnover in the human brain. Norepinephrine 84-97 D-amino acid oxidase activator Homo sapiens 21-25 22582116-3 2012 In cells perfused with Ca(2+)-free Krebs Ringer bicarbonate solution (KRBS), brief exposures to caffeine (30 mM) and norepinephrine (300 muM), which activate SR ryanodine and inositol trisphosphate receptors (RyR, IP(3)R), respectively, or 4% O(2) caused rapid transient increases in [Ca(2+)](i), indicating intracellular Ca(2+) release. Norepinephrine 117-131 inositol 1,4,5-trisphosphate receptor, type 1 Rattus norvegicus 214-220 22582116-6 2012 The IP(3)R antagonist xestospongin C (XeC, 0.1 muM) blocked Ca(2+) release to norepinephrine and hypoxia but not caffeine. Norepinephrine 78-92 inositol 1,4,5-trisphosphate receptor, type 1 Rattus norvegicus 4-10 22626578-0 2012 Adrenomedullin inhibits norepinephrine-induced contraction of rat seminal vesicle. Norepinephrine 24-38 adrenomedullin Rattus norvegicus 0-14 22372951-2 2012 Cytokines that act through gp130, such as ciliary neurotrophic factor (CNTF) decrease norepinephrine production in sympathetic neurons by suppressing TH mRNA and stimulating degradation of TH protein, leading to the loss of enzyme. Norepinephrine 86-100 Neutrophil migration (granulocyte glycoprotein) Homo sapiens 27-32 22372951-2 2012 Cytokines that act through gp130, such as ciliary neurotrophic factor (CNTF) decrease norepinephrine production in sympathetic neurons by suppressing TH mRNA and stimulating degradation of TH protein, leading to the loss of enzyme. Norepinephrine 86-100 ciliary neurotrophic factor Homo sapiens 42-69 22372951-2 2012 Cytokines that act through gp130, such as ciliary neurotrophic factor (CNTF) decrease norepinephrine production in sympathetic neurons by suppressing TH mRNA and stimulating degradation of TH protein, leading to the loss of enzyme. Norepinephrine 86-100 ciliary neurotrophic factor Homo sapiens 71-75 22322975-6 2012 Functionally, ANG II-induced downregulation of RhoA-GEFs is associated with decreased Rho kinase activation in response to endothelin-1, norepinephrine, and U-46619. Norepinephrine 137-151 ras homolog family member A Rattus norvegicus 47-51 22371491-3 2012 By utilizing the G protein-coupled receptor (GPCR) heteromer identification technology on the live cell-based bioluminescence resonance energy transfer (BRET) assay platform, our studies in human embryonic kidney 293 cells have identified norepinephrine-dependent beta-arrestin recruitment that was in turn dependent upon co-expression of alpha(1A)AR with CXCR2. Norepinephrine 239-253 calcium voltage-gated channel subunit alpha1 A Homo sapiens 339-347 22260985-4 2012 In the presence of endothelium, neurogenic and exogenous noradrenaline vasoconstrictions were enhanced by L-NOArg (n=7, P<0.05 and P<0.01 respectively) and ODQ (n=7, both P<0.05); in denuded arteries, nNOS inhibition with N(omega)-propyl-L-arginine increased neurogenic contraction (n=7, P<0.05). Norepinephrine 57-70 nitric oxide synthase 1 Sus scrofa 210-214 22253419-6 2012 In brown adipocytes in culture, norepinephrine, cAMP, and activators of PPARgamma and PPARalpha induced RBP4 gene expression and RBP4 protein release. Norepinephrine 32-46 retinol binding protein 4, plasma Mus musculus 104-108 22253419-6 2012 In brown adipocytes in culture, norepinephrine, cAMP, and activators of PPARgamma and PPARalpha induced RBP4 gene expression and RBP4 protein release. Norepinephrine 32-46 retinol binding protein 4, plasma Mus musculus 129-133 22253419-7 2012 The induction of RBP4 gene expression by norepinephrine required intact PPAR-dependent pathways, as evidenced by impaired response of the RBP4 gene expression to norepinephrine in PPARalpha-null brown adipocytes or in the presence of inhibitors of PPARgamma and PPARalpha. Norepinephrine 41-55 retinol binding protein 4, plasma Mus musculus 17-21 22253419-7 2012 The induction of RBP4 gene expression by norepinephrine required intact PPAR-dependent pathways, as evidenced by impaired response of the RBP4 gene expression to norepinephrine in PPARalpha-null brown adipocytes or in the presence of inhibitors of PPARgamma and PPARalpha. Norepinephrine 41-55 retinol binding protein 4, plasma Mus musculus 138-142 22253419-7 2012 The induction of RBP4 gene expression by norepinephrine required intact PPAR-dependent pathways, as evidenced by impaired response of the RBP4 gene expression to norepinephrine in PPARalpha-null brown adipocytes or in the presence of inhibitors of PPARgamma and PPARalpha. Norepinephrine 162-176 retinol binding protein 4, plasma Mus musculus 17-21 22253419-8 2012 PPARgamma and norepinephrine can also induce the RBP4 gene in white adipocytes, and overexpression of PPARalpha confers regulation by this PPAR subtype to white adipocytes. Norepinephrine 14-28 retinol binding protein 4, plasma Mus musculus 49-53 22253419-11 2012 The induction of the RBP4 gene expression by norepinephrine in brown adipocytes is protein synthesis dependent and requires PPARgamma-coactivator-1-alpha, which acts as a norepinephine-induced coactivator of PPAR on the RBP4 gene. Norepinephrine 45-59 retinol binding protein 4, plasma Mus musculus 21-25 22253419-11 2012 The induction of the RBP4 gene expression by norepinephrine in brown adipocytes is protein synthesis dependent and requires PPARgamma-coactivator-1-alpha, which acts as a norepinephine-induced coactivator of PPAR on the RBP4 gene. Norepinephrine 45-59 retinol binding protein 4, plasma Mus musculus 220-224 22914593-4 2012 Exercise significantly elevated endogenous norepinephrine (measured via the biomarker, salivary alpha-amylase) in both aMCI patients and controls. Norepinephrine 43-57 amylase alpha 1A Homo sapiens 87-109 23226423-8 2012 Noradrenaline- (NA-) and phenylephrine- (PE-) induced phosphorylation of Elk1 was assessed by Western blot analysis using a phospho-specific antibody. Norepinephrine 0-13 ETS transcription factor ELK1 Homo sapiens 73-77 23226423-16 2012 CONCLUSIONS: Silodosin blocks the activation of the two transcription factors, Elk1 and SRF, which is induced by noradrenaline in the human prostate. Norepinephrine 113-126 ETS transcription factor ELK1 Homo sapiens 79-83 23226423-16 2012 CONCLUSIONS: Silodosin blocks the activation of the two transcription factors, Elk1 and SRF, which is induced by noradrenaline in the human prostate. Norepinephrine 113-126 serum response factor Homo sapiens 88-91 22060292-4 2011 KEY FINDINGS: Curcumin at a concentration of 8 microm was found to suppress the increase in cell size, protein content and enhanced marker gene expression (ANF) caused by noradrenaline. Norepinephrine 171-184 natriuretic peptide A Rattus norvegicus 156-159 21885739-1 2011 The norepinephrine transporter (NET) transports norepinephrine from the synapse into presynaptic neurons, where norepinephrine regulates signaling pathways associated with cardiovascular effects and behavioral traits via binding to various receptors (e.g., beta2-adrenergic receptor). Norepinephrine 4-18 adrenoceptor beta 2 Homo sapiens 257-282 21885739-1 2011 The norepinephrine transporter (NET) transports norepinephrine from the synapse into presynaptic neurons, where norepinephrine regulates signaling pathways associated with cardiovascular effects and behavioral traits via binding to various receptors (e.g., beta2-adrenergic receptor). Norepinephrine 48-62 adrenoceptor beta 2 Homo sapiens 257-282 21738056-8 2011 Furthermore, the inhibition of ErbB2 expression in the RVLM by RNA interference significantly increased arterial pressure, HR, and urinary norepinephrine excretion in conscious WKY rats (P < 0.01). Norepinephrine 139-153 erb-b2 receptor tyrosine kinase 2 Rattus norvegicus 31-36 21726532-5 2011 Employing a novel anti-phospho-Ser-412-specific antibody, we demonstrate that this site in PKD is rapidly phosphorylated in primary cardiac myocytes exposed to hypertrophic agonists, including norepinephrine (NE) and endothelin-1 (ET-1). Norepinephrine 193-207 protein kinase D1 Homo sapiens 91-94 21613371-6 2011 In functional studies, phenylephrine and noradrenaline produced dose-dependent constriction of ophthalmic arteries that was similar in wild-type, alpha(1B)-AR(-/-), and alpha(1D)-AR(-/-) mice. Norepinephrine 41-54 calcium channel, voltage-dependent, N type, alpha 1B subunit Mus musculus 146-154 21035322-1 2011 Rapid oxidation of dopamine (DA) or L-noradrenaline (NA) by K(3)Fe(CN)(6) yields poly(DA) (PDA(C)) or poly(NA) (PNA(C)) with glucose oxidase (GOx) effectively entrapped, and such an enzyme-entrapped catecholamine polymer is cast on an Au electrode followed by chitosan (CS) strengthening for biosensing and fabrication of a biofuel cell (BFC). Norepinephrine 36-51 hydroxyacid oxidase 1 Homo sapiens 125-140 21035322-1 2011 Rapid oxidation of dopamine (DA) or L-noradrenaline (NA) by K(3)Fe(CN)(6) yields poly(DA) (PDA(C)) or poly(NA) (PNA(C)) with glucose oxidase (GOx) effectively entrapped, and such an enzyme-entrapped catecholamine polymer is cast on an Au electrode followed by chitosan (CS) strengthening for biosensing and fabrication of a biofuel cell (BFC). Norepinephrine 36-51 hydroxyacid oxidase 1 Homo sapiens 142-145 21253359-1 2011 The pancreatic beta cell harbors alpha2-adrenergic and glucagon-like peptide-1 (GLP-1) receptors on its plasma membrane to sense the corresponding ligands adrenaline/noradrenaline and GLP-1 to govern glucose-stimulated insulin secretion. Norepinephrine 166-179 glucagon Rattus norvegicus 80-85 21087442-8 2010 To evaluate the role of monoamine transporters in the psychostimulant-induced expression of FosB/DeltaFosB, we tested the antidepressant drugs reboxetine, nortriptyline, fluoxetine and venlafaxine (which target the noradrenaline and/or the 5-hydroxytryptamine transporters), the 5-hydroxytryptamine releasing agent dexfenfluramine, and the dopamine transporter inhibitor GBR12909. Norepinephrine 215-228 FosB proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 92-96 20858707-6 2010 In contrast, hOCT3 is less selective than hPMAT toward the monoamines, and the V(max)/K(m) rank order for hOCT3 is: histamine > norepinephrine, epinephrine > dopamine >5-HT. Norepinephrine 131-145 solute carrier family 22 member 3 Homo sapiens 13-18 20858707-6 2010 In contrast, hOCT3 is less selective than hPMAT toward the monoamines, and the V(max)/K(m) rank order for hOCT3 is: histamine > norepinephrine, epinephrine > dopamine >5-HT. Norepinephrine 131-145 solute carrier family 22 member 3 Homo sapiens 106-111 20858707-9 2010 Our results suggest that hOCT3 represents a major uptake(2) transporter for histamine, epinephrine, and norepinephrine. Norepinephrine 104-118 solute carrier family 22 member 3 Homo sapiens 25-30 20837485-4 2010 In this beta(2)AR sensor, norepinephrine caused signals that amounted to only 50% of those induced by epinephrine and the standard "full" agonist isoproterenol. Norepinephrine 26-40 adrenoceptor beta 2 Homo sapiens 8-17 20837485-5 2010 Furthermore, norepinephrine-induced changes in the beta(2)AR FRET sensor were slower than those induced by epinephrine (rate constants, 47 versus 128 ms). Norepinephrine 13-27 adrenoceptor beta 2 Homo sapiens 51-60 20837485-9 2010 We conclude that partial agonism of norepinephrine at the beta(2)AR is related to the induction of a different active conformation and that this conformation is efficient in signaling to G(s) and less efficient in signaling to beta-arrestin2. Norepinephrine 36-50 adrenoceptor beta 2 Homo sapiens 58-67 20599923-8 2010 Norepinephrine responses in veins from alpha(2C)-adrenoceptor knock-out (KO) mice were not different from wild type veins. Norepinephrine 0-14 adrenergic receptor, alpha 2c Mus musculus 39-47 20599923-9 2010 Yohimbine inhibited norepinephrine constrictions in alpha(2C)-adrenoceptor KO veins suggesting that there is upregulation of other alpha(2)-adrenoceptors in alpha(2C)-KO mice. Norepinephrine 20-34 adrenergic receptor, alpha 2c Mus musculus 52-60 20363235-5 2010 In addition, amitriptyline, nortriptyline and imipramine were substantially more potent in the inhibition of noradrenaline-induced intracellular Ca(2+) increases in HEK-293 cells expressing alpha(1A)- or a truncated version of alpha(1D)-adrenoceptors which traffics more efficiently towards the cell membrane than in cells expressing alpha(1B)-adrenoceptors. Norepinephrine 109-122 calcium voltage-gated channel subunit alpha1 A Homo sapiens 190-198 20363235-7 2010 The differential affinities for these receptors indicate that the alpha(1)-adrenoceptor subtype which activation is most increased by the augmented noradrenaline availability resultant from the blockade of neuronal reuptake is the alpha(1B)-adrenoceptor. Norepinephrine 148-161 adrenoceptor alpha 1B Homo sapiens 231-253 20464574-3 2010 This hypothesis derived from the results of the biochemical studies, mainly generated from our laboratory, on the possible metabolic shifts of tyrosine toward an activation of decarboxylase enzyme activity with an increased synthesis of traces amines, i.e. tyr, oct and syn, and an unphysiological synthesis of noradrenalin and dopamine. Norepinephrine 311-323 synemin Homo sapiens 224-227 20086155-0 2010 Neutrophil gelatinase-associated lipocalin expresses antimicrobial activity by interfering with L-norepinephrine-mediated bacterial iron acquisition. Norepinephrine 96-112 lipocalin 2 Homo sapiens 0-42 20056676-2 2010 Here, we show that animals with a Col4a1 missense mutation (Col4a1(+/Raw)) display focal detachment of the endothelium from the media and age-dependent defects in vascular function including a reduced response to nor-epinephrine. Norepinephrine 213-228 collagen, type IV, alpha 1 Mus musculus 34-40 20056676-2 2010 Here, we show that animals with a Col4a1 missense mutation (Col4a1(+/Raw)) display focal detachment of the endothelium from the media and age-dependent defects in vascular function including a reduced response to nor-epinephrine. Norepinephrine 213-228 collagen, type IV, alpha 1 Mus musculus 60-66 19883655-3 2010 Calcineurin-mAKAPbeta complex formation is increased in the presence of Ca(2+)/calmodulin and in norepinephrine-stimulated primary cardiac myocytes. Norepinephrine 97-111 A kinase (PRKA) anchor protein 6 Mus musculus 12-21 19883655-4 2010 This binding is of functional significance because myocytes exhibit diminished norepinephrine-stimulated hypertrophy when expressing a mAKAPbeta mutant incapable of binding calcineurin. Norepinephrine 79-93 A kinase (PRKA) anchor protein 6 Mus musculus 135-144 19818755-0 2010 Noradrenaline induces IL-1ra and IL-1 type II receptor expression in primary glial cells and protects against IL-1beta-induced neurotoxicity. Norepinephrine 0-13 interleukin 1 receptor antagonist Rattus norvegicus 22-28 19818755-6 2010 Here we report that noradrenaline induces production of IL-1ra and IL-1RII from primary rat mixed glial cells. Norepinephrine 20-33 interleukin 1 receptor antagonist Rattus norvegicus 56-62 19818755-8 2010 Our results demonstrate that the ability of noradrenaline to induce IL-1ra and IL-1RII is mediated via beta-adrenoceptor activation and downstream activation of protein kinase A and extracellular signal-regulated kinase (ERK). Norepinephrine 44-57 interleukin 1 receptor antagonist Rattus norvegicus 68-74 21299064-5 2010 These effects of GAL in promoting overconsumption may involve various neurotransmitters, with GAL facilitating intake by stimulating norepinephrine and dopamine and reducing satiety by decreasing serotonin and acetylcholine. Norepinephrine 133-147 galanin and GMAP prepropeptide Homo sapiens 94-97 19968887-6 2009 In contrast, activated CD8+ T lymphocytes showed a reduced migratory activity in the presence of norepinephrine and substance P. Norepinephrine 97-111 CD8a molecule Homo sapiens 23-26 19968887-7 2009 With regard to extravasation we found norepinephrine to induce adhesion of activated CD8+ T cells: norepinephrine increased the interleukin-8 release from endothelium, which in turn had effect on the activated CXCR1+ CD8+ T cells. Norepinephrine 38-52 CD8a molecule Homo sapiens 85-88 19968887-7 2009 With regard to extravasation we found norepinephrine to induce adhesion of activated CD8+ T cells: norepinephrine increased the interleukin-8 release from endothelium, which in turn had effect on the activated CXCR1+ CD8+ T cells. Norepinephrine 38-52 C-X-C motif chemokine receptor 1 Homo sapiens 210-215 19968887-7 2009 With regard to extravasation we found norepinephrine to induce adhesion of activated CD8+ T cells: norepinephrine increased the interleukin-8 release from endothelium, which in turn had effect on the activated CXCR1+ CD8+ T cells. Norepinephrine 38-52 CD8a molecule Homo sapiens 217-220 19968887-7 2009 With regard to extravasation we found norepinephrine to induce adhesion of activated CD8+ T cells: norepinephrine increased the interleukin-8 release from endothelium, which in turn had effect on the activated CXCR1+ CD8+ T cells. Norepinephrine 99-113 CD8a molecule Homo sapiens 85-88 19968887-7 2009 With regard to extravasation we found norepinephrine to induce adhesion of activated CD8+ T cells: norepinephrine increased the interleukin-8 release from endothelium, which in turn had effect on the activated CXCR1+ CD8+ T cells. Norepinephrine 99-113 C-X-C motif chemokine receptor 1 Homo sapiens 210-215 19968887-7 2009 With regard to extravasation we found norepinephrine to induce adhesion of activated CD8+ T cells: norepinephrine increased the interleukin-8 release from endothelium, which in turn had effect on the activated CXCR1+ CD8+ T cells. Norepinephrine 99-113 CD8a molecule Homo sapiens 217-220 19295473-0 2009 Central cannabinoid 1 receptor antagonist administration prevents endotoxic hypotension affecting norepinephrine release in the preoptic anterior hypothalamic area. Norepinephrine 98-112 cannabinoid receptor 1 Rattus norvegicus 8-21 19693491-16 2009 The PDE2-selective inhibitor erythro-9-[2-hydroxy-3-nonyl]adenine caused marginal bradycardia at 30 microM and tended to reduce the chronotropic potency of (-)-noradrenaline. Norepinephrine 156-173 phosphodiesterase 2A Rattus norvegicus 4-8 19464349-3 2009 We hypothesized that the 5-HT and norepinephrine reuptake inhibitor, venlafaxine, would stimulate BDNF expression and alter LTP more effectively than the selective 5-HT reuptake inhibitor, citalopram. Norepinephrine 34-48 brain-derived neurotrophic factor Rattus norvegicus 98-102 19632110-2 2009 Synthesis of the two diastereomeric isomers of the molecule followed by chiral resolution of each enantiomer revealed the (2R,3S)-isomer to be a potent norepinephrine reuptake inhibitor (IC(50)=28 nM) with excellent selectivity over the dopamine transporter and 13-fold selectivity over the serotonin transporter. Norepinephrine 152-166 solute carrier family 6 member 3 Homo sapiens 237-257 19573018-7 2009 Transfection of shRNAs specific to Phox2a or Phox2b genes significantly reduced mRNA and protein levels of NET and DBH after shutdown of endogenous Phox2, which was accompanied by a decreased [(3)H]norepinephrine uptake. Norepinephrine 198-212 paired like homeobox 2B Homo sapiens 45-51 19500686-4 2009 We show that norepinephrine affects the production and release of Dr fimbriae in Afa/Dr DAEC WT-IH11128 bacteria. Norepinephrine 13-27 AFA Homo sapiens 81-84 19403649-0 2009 Mice lacking the ADP ribosyl cyclase CD38 exhibit attenuated renal vasoconstriction to angiotensin II, endothelin-1, and norepinephrine. Norepinephrine 121-135 CD38 antigen Mus musculus 37-41 19553450-5 2009 We hypothesized that since these animals exhibit deficits in other monoamine systems (norepinephrine and serotonin), which are known to regulate some of these behaviors, the VMAT2-deficient mice may display some of the nonmotor symptoms associated with PD. Norepinephrine 86-100 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 174-179 19217831-7 2009 The peak values of IL-6 and IL-8 also correlated positively with the peak values of noradrenaline (r=0.603 and r=0.681, respectively).These results suggest that a pronounced activation of the sympathetic nervous system and the inflammatory response occurs in acute stage of SAH. Norepinephrine 84-97 interleukin 6 Canis lupus familiaris 19-23 19179649-7 2009 At 7 mo, alpha(2A)/alpha(2C)ARKO mice displayed exercise intolerance and increased muscular norepinephrine, muscular atrophy, capillary rarefaction, and increased oxidative stress. Norepinephrine 92-106 adrenergic receptor, alpha 2c Mus musculus 19-27 19452616-7 2009 Further, the results for choline acetyltransferase indicate that early depletion of norepinephrine compromises development of acetylcholine systems, consistent with a trophic role for this neurotransmitter. Norepinephrine 84-98 choline O-acetyltransferase Rattus norvegicus 25-50 19120138-5 2008 HPA axis responses to IL-1beta and CCK can be reinstated in pregnant rats by systemic administration of the opioid receptor antagonist naloxone, and when infused directly into the PVN, naloxone restores noradrenaline release in the PVN following IL-1beta treatment. Norepinephrine 203-216 cholecystokinin Rattus norvegicus 35-38 18772317-1 2008 Fluorescence studies with purified human beta(2)-adrenoceptor (beta(2)AR) revealed that the endogenous catecholamines, (-)-epinephrine (EPI), (-)-norepinephrine (NE), and dopamine (DOP), stabilize distinct active receptor conformations. Norepinephrine 142-160 adrenoceptor beta 2 Homo sapiens 41-61 18772317-1 2008 Fluorescence studies with purified human beta(2)-adrenoceptor (beta(2)AR) revealed that the endogenous catecholamines, (-)-epinephrine (EPI), (-)-norepinephrine (NE), and dopamine (DOP), stabilize distinct active receptor conformations. Norepinephrine 142-160 adrenoceptor beta 2 Homo sapiens 63-72 18554250-1 2008 In the mammalian pineal gland, the rhythm in melatonin biosynthesis depends on the norepinephrine (NE)-driven regulation of arylalkylamine N-acetyltransferase (AANAT), the penultimate enzyme of melatonin biosynthesis. Norepinephrine 83-97 aralkylamine N-acetyltransferase Homo sapiens 124-158 18554250-1 2008 In the mammalian pineal gland, the rhythm in melatonin biosynthesis depends on the norepinephrine (NE)-driven regulation of arylalkylamine N-acetyltransferase (AANAT), the penultimate enzyme of melatonin biosynthesis. Norepinephrine 83-97 aralkylamine N-acetyltransferase Homo sapiens 160-165 19067837-7 2008 Expression of TLR-9 and TLR-11 in cells exposed to norepinephrine (NE) and parasites was significantly decreased when compared to cells exposed to parasites only. Norepinephrine 51-65 toll-like receptor 9 Mus musculus 14-19 18775326-2 2008 In lymphoid organs, the neurotransmitter norepinephrine stimulates beta(2)-adrenergic receptors on B lymphocytes to promote CREB-dependent expression of genes like the B cell Oct 2 coactivator (OCA-B). Norepinephrine 41-55 POU domain, class 2, associating factor 1 Mus musculus 194-199 18840973-2 2008 They include transporters for norepinephrine, dopamine and serotonin, which are encoded by the SLC6A2, SLC6A3, and SLC6A4 genes, respectivily. Norepinephrine 30-44 solute carrier family 6 member 2 Canis lupus familiaris 95-101 18505450-8 2008 At 0.3, 1.0 and 3.0 nmol/animal, GLP-1 dose-dependently elevated plasma levels of noradrenaline and adrenaline and the 1.0 nmol GLP-1-induced response was dose-dependently reduced by 5 and 10 nmol/animal exendin (5-39), a selective GLP-1 receptor antagonist. Norepinephrine 82-95 glucagon Rattus norvegicus 33-38 18505450-14 2008 These results suggest that, in rats, centrally administered GLP-1 induces the secretion of adrenaline from the adrenal medulla by brain thromboxane A(2)-mediated mechanisms, whereas the peptide evokes the release of noradrenaline from sympathetic nerves by brain prostanoids via mechanisms other than those mediated by thromboxane A(2). Norepinephrine 216-229 glucagon Rattus norvegicus 60-65 18644202-2 2008 Noradrenaline-induced relaxations of the muscularis mucosae in each region were unaffected by atenolol, butoxamine or propranolol, but they were attenuated by the selective beta3-adrenoceptor antagonist cyanopindolol. Norepinephrine 0-13 adrenoceptor beta 3 Rattus norvegicus 173-191 18644202-8 2008 Distal colonic muscularis mucosae lacked excitatory adrenoceptors and only responded to noradrenaline with beta3-adrenoceptor-mediated relaxations. Norepinephrine 88-101 adrenoceptor beta 3 Rattus norvegicus 107-125 18474603-5 2008 Furthermore, the C-terminal pro-TRH-derived peptides were more efficiently released in response to KCl and norepinephrine, a natural secretagogue of TRH. Norepinephrine 107-121 thyrotropin releasing hormone Mus musculus 28-35 18474603-5 2008 Furthermore, the C-terminal pro-TRH-derived peptides were more efficiently released in response to KCl and norepinephrine, a natural secretagogue of TRH. Norepinephrine 107-121 thyrotropin releasing hormone Mus musculus 32-35 18577832-7 2008 The treatment of anti-HMGB1 mAb significantly increased the plasma troponin-T and norepinephrine (NE) content in the heart in comparison with the control (p<0.05). Norepinephrine 82-96 high mobility group box 1 Rattus norvegicus 22-27 18485637-2 2008 Interaction of c-kit receptor with its ligand-SCF potent enhances the melanocytic melanogenesis, which can be repressed by norepinephrine (NE). Norepinephrine 123-137 KIT ligand Homo sapiens 46-49 18423439-4 2008 In addition, the corticotropin-releasing factor-induced elevation of noradrenaline release in the hypothalamic paraventricular nucleus and plasma corticosterone were abolished by hexamethonium, a non-selective nicotinic acetylcholine receptor antagonist, at 1.8 micromol/animal, intracerebroventricularly, and alpha-conotoxin MII, a potent alpha(3)beta(2) nicotinic acetylcholine receptor antagonist, at 30 nmol/animal, i.c.v. Norepinephrine 69-82 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 210-242 18423439-4 2008 In addition, the corticotropin-releasing factor-induced elevation of noradrenaline release in the hypothalamic paraventricular nucleus and plasma corticosterone were abolished by hexamethonium, a non-selective nicotinic acetylcholine receptor antagonist, at 1.8 micromol/animal, intracerebroventricularly, and alpha-conotoxin MII, a potent alpha(3)beta(2) nicotinic acetylcholine receptor antagonist, at 30 nmol/animal, i.c.v. Norepinephrine 69-82 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 356-388 18480676-3 2008 Among these are several genes associated with the catecholaminergic system including the dopamine receptor genes (DRD4 and DRD5), the dopamine transporter gene, and the gene for dopamine beta-hydroxylase, which catalyzes conversion of dopamine to norepinephrine. Norepinephrine 247-261 solute carrier family 6 member 3 Homo sapiens 134-154 18177483-0 2008 Chronic noradrenaline increases renal expression of NHE-3, NBC-1, BSC-1 and aquaporin-2. Norepinephrine 8-21 solute carrier family 12 member 1 Rattus norvegicus 66-71 18177483-13 2008 We conclude that noradrenaline-induced increases in the expression of NHE-3, NBC-1, BSC-1 and aquaporin-2 are likely to play an important role in the regulation of salt and water transport by noradrenaline in the kidney and may explain, at least in part, the altered renal sodium and water handling associated with overactivation of the sympathetic system. Norepinephrine 17-30 solute carrier family 12 member 1 Rattus norvegicus 84-89 18065472-10 2008 Norepinephrine and dopamine occupy the same binding region, between TM3, TM5, and TM6, whereas the binding site of salbutamol is shifted toward TM4. Norepinephrine 0-14 tropomyosin 3 Homo sapiens 68-71 18065472-10 2008 Norepinephrine and dopamine occupy the same binding region, between TM3, TM5, and TM6, whereas the binding site of salbutamol is shifted toward TM4. Norepinephrine 0-14 tropomyosin 3 Homo sapiens 73-76 18364034-0 2008 Matrix metalloproteinases MMP2 and MMP9 are upregulated by noradrenaline in the mouse neuroendocrine hypothalamus. Norepinephrine 59-72 matrix metallopeptidase 2 Mus musculus 26-30 18364034-5 2008 We investigated the possible regulation of the two gelatinases, MMP2 and MMP9, by noradrenaline (NA) in the mouse neuroendocrine hypothalamus. Norepinephrine 82-95 matrix metallopeptidase 2 Mus musculus 64-68 18219438-1 2008 Our aim was to study fracture risk in users of various antidepressants (tricyclic antidepressants, selective serotonin reuptake inhibitors, and the group of other antidepressants including monoamine oxidase B inhibitors and drugs with effect on the norepinephrine system) and its relationship with effects on inhibition of the cholinergic and serotonin transporter system. Norepinephrine 249-263 monoamine oxidase B Homo sapiens 189-208 18193048-1 2008 Morphine, a powerful analgesic, and norepinephrine, the principal neurotransmitter of sympathetic nerves, exert major inhibitory effects on both peripheral and brain neurons by activating distinct cell-surface G protein-coupled receptors-the mu-opioid receptor (MOR) and alpha2A-adrenergic receptor (alpha2A-AR), respectively. Norepinephrine 36-50 adrenoceptor alpha 2A Homo sapiens 271-298 18193048-1 2008 Morphine, a powerful analgesic, and norepinephrine, the principal neurotransmitter of sympathetic nerves, exert major inhibitory effects on both peripheral and brain neurons by activating distinct cell-surface G protein-coupled receptors-the mu-opioid receptor (MOR) and alpha2A-adrenergic receptor (alpha2A-AR), respectively. Norepinephrine 36-50 adrenoceptor alpha 2A Homo sapiens 300-310 18193048-4 2008 We discovered that morphine binding to the MOR triggers a conformational change in the norepinephrine-occupied alpha2A-AR that inhibits its signaling to G(i) and the downstream MAP kinase cascade. Norepinephrine 87-101 adrenoceptor alpha 2A Homo sapiens 111-121 18055114-3 2008 The distribution of CB1 receptors on noradrenergic fibers in the frontal cortex suggests this may be one potential site for the regulation of norepinephrine release. Norepinephrine 142-156 cannabinoid receptor 1 Rattus norvegicus 20-23 18240382-0 2008 1-(2-Phenoxyphenyl)methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity. Norepinephrine 56-69 sarcosine dehydrogenase Homo sapiens 33-36 18157476-7 2007 The results suggest that noradrenaline release secondary to the activation of kappa-bungarotoxin-sensitive nAChRs participates in LTP-like response induced by nicotine in the hippocampal CA1 region. Norepinephrine 25-38 carbonic anhydrase 1 Homo sapiens 187-190 17171299-6 2007 Using our well, established three-dimensional collagen-based cell migration assay, we show that engagement of N-cadherin results in a significant decrease of the spontaneous and the norepinephrine-induced migration of MDA-MB-468 breast carcinoma cells, which was due to an increase in the average break length. Norepinephrine 182-196 cadherin 2 Homo sapiens 110-120 17951539-1 2007 To examine whether norepinephrine, through activation of alpha1b-adrenergic receptor, regulates male fertility and testicular functions, we used alpha1b-adrenergic receptor knockout (alpha1b-AR-KO) mice. Norepinephrine 19-33 calcium channel, voltage-dependent, N type, alpha 1B subunit Mus musculus 57-64 17612521-6 2007 Compared to group D, group Din was characterized by diminished blood glucose concentration ( approximately 1.6 fold), reduced systolic and diastolic blood pressure ( approximately 1.3 fold) and heart rate ( approximately 1.6 fold), as well as by increased contractile response of the renal artery to noradrenaline ( approximately 1.84 fold) and of the impeded vasodilator response to acetylcholine ( approximately 1.81 fold) and sodium nitroprusside ( approximately 1.42 fold). Norepinephrine 300-313 RIKEN cDNA 4930453N24 gene Mus musculus 27-30 17565006-4 2007 However, we found that the neurogenic contractile response of vasa deferentia from Entpd1-null (CD39(-/-)) mice was attenuated and accompanied by reduced activity of pre- and postsynaptic P2XR, whereas contractile responses to K(+) or norepinephrine remained intact. Norepinephrine 235-249 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 83-89 17565006-5 2007 In addition, the magnitude of ATP and norepinephrine exocytosis from cardiac synaptosomes was decreased in CD39(-/-) mice. Norepinephrine 38-52 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 107-111 17565006-12 2007 Our findings emphasize the cardioprotective role of neuronal CD39: by reducing presynaptic facilitatory effects of neurotransmitter ATP, CD39 attenuates norepinephrine release and its dysfunctional consequences. Norepinephrine 153-167 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 61-65 17565006-12 2007 Our findings emphasize the cardioprotective role of neuronal CD39: by reducing presynaptic facilitatory effects of neurotransmitter ATP, CD39 attenuates norepinephrine release and its dysfunctional consequences. Norepinephrine 153-167 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 137-141 17827867-1 2007 The mechanism for noradrenaline (NA)-induced increases in intracellular Ca(2+) concentration ([Ca(2+)](i)) and physiological significance of Na(+) influx through receptor-operated channels (ROCs) and store-operated channels (SOCs) were studied in Chinese hamster ovary (CHO) cells stably expressing human alpha(1A)-adrenoceptor (alpha(1A)-AR). Norepinephrine 18-31 calcium voltage-gated channel subunit alpha1 A Homo sapiens 305-313 17597580-1 2007 Monoamine oxidase B (MAO-B) functions in the deamination of monoamines, including dopamine and norepinephrine. Norepinephrine 95-109 monoamine oxidase B Homo sapiens 0-19 17597580-1 2007 Monoamine oxidase B (MAO-B) functions in the deamination of monoamines, including dopamine and norepinephrine. Norepinephrine 95-109 monoamine oxidase B Homo sapiens 21-26 17507162-9 2007 In addition, Ca(2+) currents were inhibited in a voltage-dependent manner following exposure to oxotremorine-M (Oxo-M), norepinephrine and ATP via muscarinic acetylcholine receptor 2 (M(2) AChR) subtype, adrenergic and P2Y purinergic receptors, respectively. Norepinephrine 120-134 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 189-193 17320309-5 2007 Recent findings indicate that diazepam exerts an inhibitory activity on different isoforms of the enzyme cyclic nucleotide phosphodiesterase, which can be found in the heart muscle and also show that diazepam potentate the positive inotropic effect of both noradrenaline and adrenaline, which subsequently leads to increase in myocardial contractility. Norepinephrine 257-270 phosphodiesterase 3B Homo sapiens 105-140 17079456-0 2006 Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells. Norepinephrine 0-14 matrix metallopeptidase 9 Homo sapiens 120-125 17079456-2 2006 The purpose of this study is to determine if the stress hormone norepi can influence the expression of MMP-2, MMP-9, and VEGF in nasopharyngeal carcinoma (NPC) tumors by using three NPC tumor cell lines. Norepinephrine 64-70 matrix metallopeptidase 9 Homo sapiens 110-115 16531006-9 2006 Furthermore, cotransfection of alpha2A-adrenergic receptor and APLP1 into HEK293 cells significantly increased norepinephrine mediated inhibition of adenylate cyclase activity. Norepinephrine 111-125 adrenoceptor alpha 2A Homo sapiens 31-58 16531006-9 2006 Furthermore, cotransfection of alpha2A-adrenergic receptor and APLP1 into HEK293 cells significantly increased norepinephrine mediated inhibition of adenylate cyclase activity. Norepinephrine 111-125 amyloid beta precursor like protein 1 Homo sapiens 63-68 16556729-8 2006 However, the excretion of epinephrine, norepinephrine, and dopamine was significantly elevated in the Chga null mutants. Norepinephrine 39-53 chromogranin A Mus musculus 102-106 16822586-1 2006 CART is expressed abundantly in the hypothalamic paraventricular nucleus and locus coeruleus, major corticotropin releasing factor (CRF) and noradrenaline sources, respectively. Norepinephrine 141-154 CART prepropeptide Rattus norvegicus 0-4 16551834-2 2006 Adrenomedullin (1 nM-0.3 microM) produced concentration-dependent relaxation of endothelium-denuded mesenteric artery rings precontracted with norepinephrine at a concentration required to produce 70% of maximal response (ED70). Norepinephrine 143-157 adrenomedullin Rattus norvegicus 0-14 16583235-2 2006 PPI is also disrupted by the norepinephrine alpha-1 agonist, cirazoline, and the PPI-disruptive effects of the indirect dopamine agonist amphetamine are opposed by the norepinephrine reuptake inhibitor, desipramine. Norepinephrine 29-43 UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus 44-51 16585966-0 2006 Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion. Norepinephrine 70-84 renin Cavia porcellus 26-31 16585966-4 2006 Local generation of cardiac Ang II from mast cell-derived renin also elicited norepinephrine release from isolated sympathetic nerve terminals. Norepinephrine 78-92 renin Cavia porcellus 58-63 16585966-11 2006 Thus, mast cell-derived renin is pivotal for activating a cardiac renin-angiotensin system leading to excessive norepinephrine release in ischemia/reperfusion. Norepinephrine 112-126 renin Cavia porcellus 24-29 16585966-11 2006 Thus, mast cell-derived renin is pivotal for activating a cardiac renin-angiotensin system leading to excessive norepinephrine release in ischemia/reperfusion. Norepinephrine 112-126 renin Cavia porcellus 66-71 16336212-1 2006 We demonstrated previously that membrane depolarization and excitatory receptor agonists such as noradrenaline induce Ca2+-dependent Rho activation in VSM (vascular smooth muscle), resulting in MP (myosin phosphatase) inhibition through the mechanisms involving Rho kinase-mediated phosphorylation of its regulatory subunit MYPT1. Norepinephrine 97-110 protein phosphatase 1, regulatory subunit 12A Rattus norvegicus 324-329 16515684-2 2006 The transporters for the monoamines dopamine, norepinephrine, and serotonin (DAT, NET, and SERT) are targets for several popular psychostimulant drugs of abuse. Norepinephrine 46-60 solute carrier family 6 member 3 Homo sapiens 77-80 16495759-2 2006 In this study we explored whether neurotensin, a neuropeptide found in heart tissue, could modify myocardial norepinephrine release in spontaneously hypertensive rats (SHR). Norepinephrine 109-123 neurotensin Rattus norvegicus 34-45 16495759-4 2006 Neurotensin increased coronary effluent norepinephrine concentrations and induced positive inotropic responses, effects that were enhanced in spontaneously hypertensive rats compared with Wistar Kyoto rats. Norepinephrine 40-54 neurotensin Rattus norvegicus 0-11 16495759-8 2006 In summary, in the hypertensive heart there is an increased sensitivity to neurotensin"s actions on myocardial norepinephrine release and subsequent contractile changes. Norepinephrine 111-125 neurotensin Rattus norvegicus 75-86 16428474-12 2006 Norepinephrine also increased tumor cell expression of MMP-2 (P = 0.02 for both SKOV3 and EG cells) and MMP-9 (P = 0.01 and 0.04, respectively), and pharmacologic blockade of MMPs abrogated the effects of norepinephrine on tumor cell invasive potential. Norepinephrine 0-14 matrix metallopeptidase 9 Homo sapiens 104-109 16687308-3 2006 At the beginning of the night, norepinephrine (NE) elicits a rapid and sustained phosphorylation of CREB into pCREB and a transient synthesis of the immediate early gene products c-FOS and c-JUN that peak 3 h after dark onset. Norepinephrine 31-45 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 179-184 16102757-6 2006 The affinity of the beta2-adrenoceptor for isoprenaline and adrenaline (beta2-values of 8.3 and 7.9) was clearly higher than for noradrenaline (beta2-value of 6.5). Norepinephrine 129-142 beta-2 adrenergic receptor Oncorhynchus mykiss 20-38 16479149-2 2006 The accessory beta(3) subunits of Ca(2+) channels (Ca(V)beta(3)) are preferentially associated with the alpha(1B) subunit to form N-type Ca(2+) channels, and are therefore expected to play a functional role in the stimulation-evoked release of noradrenaline. Norepinephrine 244-257 calcium channel, voltage-dependent, N type, alpha 1B subunit Mus musculus 104-112 16328376-5 2006 METHODS: CB(1) receptor occupancy was measured using [(3)H] SR141716A, and these occupancies were related to potencies to mediate increases in dopamine (DA) and norepinephrine (NE) release measured with microdialysis and decreases in consumption of a highly palatable diet (HP). Norepinephrine 161-175 cannabinoid receptor 1 Rattus norvegicus 9-14 16285953-2 2005 We tested the hypothesis that pretreatment with JTC-017, a specific corticotropin-releasing hormone receptor 1 antagonist, blocks colorectal distention-induced hippocampal noradrenaline release and visceral perception in rats. Norepinephrine 172-185 corticotropin releasing hormone receptor 1 Rattus norvegicus 68-110 16285953-12 2005 CONCLUSIONS: Our results suggest that JTC-017, a specific corticotropin-releasing hormone receptor 1 antagonist, attenuates hippocampal noradrenaline release, visceral perception, adrenocorticotropic hormone release, and anxiety after acute colorectal distention in rats. Norepinephrine 136-149 corticotropin releasing hormone receptor 1 Rattus norvegicus 58-100 16869081-0 2005 [Effects of endogenous endothelin 1 on norepinephrine release and arrhythmia in cardiac ischemia and reperfusion--a study by Langendorff perfusion system using the heart excised from a guinea pig]. Norepinephrine 39-53 endothelin-1 Cavia porcellus 23-35 16140489-0 2005 Changes in P2Y2 receptor localization on adrenaline- and noradrenaline-containing chromaffin cells in the rat adrenal gland during development and aging. Norepinephrine 57-70 purinergic receptor P2Y2 Rattus norvegicus 11-15 16140489-4 2005 However, immunoreactivity for adrenaline-containing cells in the P2Y2 receptor-labeled chromaffin cells increased with increasing age and at 1 week post-natal almost all chromaffin cells were positive for both P2Y2 and phenyl ethanolamine-N-methyltransferase, while noradrenaline-containing cells were minimal. Norepinephrine 266-279 purinergic receptor P2Y2 Rattus norvegicus 65-69 16140489-6 2005 In the aging rat adrenals, P2Y2 receptor-immunoreactivity was localized in subpopulations of both adrenaline and noradrenaline-producing cells. Norepinephrine 113-126 purinergic receptor P2Y2 Rattus norvegicus 27-31 16039007-1 2005 Alpha1-adrenoreceptors (AR), of which three subtypes exist (alpha1A-, alpha1B- and alpha1D-AR) are G-protein-coupled receptors that mediate the actions of norepinephrine and epinephrine both peripherally and centrally. Norepinephrine 155-169 calcium voltage-gated channel subunit alpha1 A Homo sapiens 60-67 16113694-5 2005 However, the CRC maximum responses to NAd in alpha(1D)- and alpha(1BD)-KO mice were significantly lower than those in WT and alpha(1B)-KO mice. Norepinephrine 38-41 calcium channel, voltage-dependent, N type, alpha 1B subunit Mus musculus 60-68 16254819-7 2005 A close relationship was found between affinities obtained for cloned alpha (1A)-AR and inhibitory potencies on noradrenaline-induced contraction or inositol phosphate accumulation in tail artery, confirming that there is a homogeneous functional population of alpha(1A)-AR in this vessel. Norepinephrine 112-125 calcium voltage-gated channel subunit alpha1 A Homo sapiens 70-79 16154127-2 2005 Exogenous neurotensin evoked contractile responses in isolated ventricular preparations, which were equivalent in magnitude to those of norepinephrine and histamine, but greater than those for serotonin and angiotensin II. Norepinephrine 136-150 neurotensin Rattus norvegicus 10-21 16154127-6 2005 Neurotensin elicited an increase in coronary effluent norepinephrine concentrations, and a strong relationship between the magnitude of neurotensin-induced contractile effects and increments in myocardial norepinephrine release were noted. Norepinephrine 54-68 neurotensin Rattus norvegicus 0-11 16154127-6 2005 Neurotensin elicited an increase in coronary effluent norepinephrine concentrations, and a strong relationship between the magnitude of neurotensin-induced contractile effects and increments in myocardial norepinephrine release were noted. Norepinephrine 54-68 neurotensin Rattus norvegicus 136-147 16154127-6 2005 Neurotensin elicited an increase in coronary effluent norepinephrine concentrations, and a strong relationship between the magnitude of neurotensin-induced contractile effects and increments in myocardial norepinephrine release were noted. Norepinephrine 205-219 neurotensin Rattus norvegicus 0-11 16154127-6 2005 Neurotensin elicited an increase in coronary effluent norepinephrine concentrations, and a strong relationship between the magnitude of neurotensin-induced contractile effects and increments in myocardial norepinephrine release were noted. Norepinephrine 205-219 neurotensin Rattus norvegicus 136-147 16026859-5 2005 Norepinephrine and dopamine increased lymphocyte activation accompanied by augmented Th1 and Th2 type cytokine production. Norepinephrine 0-14 negative elongation factor complex member C/D Homo sapiens 85-88 16292510-0 2005 Muller Cells as a source of brain-derived neurotrophic factor in the retina: noradrenaline upregulates brain-derived neurotrophic factor levels in cultured rat Muller cells. Norepinephrine 77-90 brain-derived neurotrophic factor Rattus norvegicus 28-61 16292510-0 2005 Muller Cells as a source of brain-derived neurotrophic factor in the retina: noradrenaline upregulates brain-derived neurotrophic factor levels in cultured rat Muller cells. Norepinephrine 77-90 brain-derived neurotrophic factor Rattus norvegicus 103-136 16292510-6 2005 Noradrenaline administration caused an upregulation of BDNF mRNA and protein expression by cultured Muller cells. Norepinephrine 0-13 brain-derived neurotrophic factor Rattus norvegicus 55-59 16282996-3 2005 Our results suggest that trophic function of acetylcholine and norepinephrine is associated with regulation of Na,K-ATPase activity as a signal transducer. Norepinephrine 63-77 ATPase Na+/K+ transporting subunit alpha 1 Gallus gallus 111-122 16003188-0 2005 Angiotensin I-converting enzyme-dependent and neutral endopeptidase-dependent generation and degradation of angiotensin II contrarily modulate noradrenaline release: implications for vasopeptidase-inhibitor therapy? Norepinephrine 143-156 membrane metallo-endopeptidase Rattus norvegicus 46-67 15705737-1 2005 Cytosolic phospholipase A(2) (cPLA(2)) is activated and translocated to the nuclear envelope by various vasoactive agents, including norepinephrine (NE), and releases arachidonic acid (AA) from tissue phospholipids. Norepinephrine 133-147 cytosolic phospholipase A2 Oryctolagus cuniculus 0-37 14642444-13 2003 Phosphorylation of MARCKS has been reported to play an important role in the release of neurotransmitters, such as noradrenaline and serotonin. Norepinephrine 115-128 myristoylated alanine rich protein kinase C substrate Rattus norvegicus 19-25 14654758-10 2003 At baseline, 24-h urinary excretion of levodopa (L-DOPA), dopamine and noradrenaline was increased by 145, 85 and 74%, respectively, in COMT (-/-) mice compared with wild-type controls. Norepinephrine 71-84 catechol-O-methyltransferase Mus musculus 136-140 14709821-5 2003 In the aortae isolated from both CD38(+/+) and CD38(-/-) mice, KCl, phenylephrine and norepinephrine induced concentration-dependent contraction. Norepinephrine 86-100 CD38 antigen Mus musculus 33-37 14709821-5 2003 In the aortae isolated from both CD38(+/+) and CD38(-/-) mice, KCl, phenylephrine and norepinephrine induced concentration-dependent contraction. Norepinephrine 86-100 CD38 antigen Mus musculus 47-51 14709821-8 2003 Phenylephrine- and norepinephrine-induced contractions were, however, significantly smaller in the aortae from CD38(-/-) mice than in those from CD38(+/+) mice. Norepinephrine 19-33 CD38 antigen Mus musculus 111-115 14709821-8 2003 Phenylephrine- and norepinephrine-induced contractions were, however, significantly smaller in the aortae from CD38(-/-) mice than in those from CD38(+/+) mice. Norepinephrine 19-33 CD38 antigen Mus musculus 145-149 12959998-3 2003 Therefore, the effect of testosterone, 17 beta-estradiol, progesterone, and norepinephrine (NE) on adrenergic receptor (AR) gene expression (alpha 2A-, beta 1-, -, and beta 3-AR) and lipolytic activity was investigated in differentiated brown adipocytes in culture. Norepinephrine 76-90 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 141-177 12820982-0 2003 Implication of ionotropic glutamate receptors in the release of noradrenaline in hippocampal CA1 and CA3 subregions under oxygen and glucose deprivation. Norepinephrine 64-77 carbonic anhydrase 1 Homo sapiens 93-96 12820982-5 2003 Maximum effect on noradrenaline release was observed in CA1 region. Norepinephrine 18-31 carbonic anhydrase 1 Homo sapiens 56-59 12820982-9 2003 The AMPA receptor antagonist GYKI-53784 had no effect in CA3, but partly reduced noradrenaline release in CA1. Norepinephrine 81-94 carbonic anhydrase 1 Homo sapiens 106-109 12820982-10 2003 Our results suggest that ionotropic glutamate receptors seem to be implicated in the massive cytoplasmic release of noradrenaline in CA1 what may contribute to its selective vulnerability. Norepinephrine 116-129 carbonic anhydrase 1 Homo sapiens 133-136 14561937-3 2003 Neuromedin U administration facilitated noradrenaline release in the supraoptic nucleus. Norepinephrine 40-53 neuromedin U Rattus norvegicus 0-12 12837768-4 2003 Of 18 mutations where hNET amino acid residues were exchanged with those of the human dopamine transporter, MrIA had increased potency for inhibition of [3H]norepinephrine uptake for three mutations (in predicted extracellular loops 3 and 4 and transmembrane domain (TMD) 8) and decreased potency for one mutation (in TMD6 and intracellular loop (IL) 3). Norepinephrine 157-171 solute carrier family 6 member 3 Homo sapiens 86-106 12807698-0 2003 Norepinephrine transport by the extraneuronal monoamine transporter in human bronchial arterial smooth muscle cells. Norepinephrine 0-14 solute carrier family 22 member 3 Homo sapiens 32-67 14512028-9 2003 Our data suggest that HAND2 regulates cell type-specific expression of norepinephrine in concert with Phox2a by a novel mechanism. Norepinephrine 71-85 heart and neural crest derivatives expressed 2 Homo sapiens 22-27 12824451-5 2003 CPT tended to cause a larger increase in mean arterial blood pressure in older men (older (O): 16 +/- 3 mmHg; younger (Y): 10 +/- 2 mmHg) during exercise, but increases in arterial noradrenaline were similar (O: 2.56 +/- 0.96 nM; Y: 1.98 +/- 0.40 nM). Norepinephrine 181-194 choline phosphotransferase 1 Homo sapiens 0-3 12904082-3 2003 Derivatives 6 and 7 were able to relax the prostatic portion of rat vas deferens contracted by (-)-noradrenaline because of both their alpha(1A)-antagonist and their NO-donor properties. Norepinephrine 95-112 calcium voltage-gated channel subunit alpha1 A Homo sapiens 135-143 12871047-9 2003 Physiological substrates for EMT include the monoamines serotonin, dopamine, noradrenaline, adrenaline and histamine. Norepinephrine 77-90 solute carrier family 22 member 3 Homo sapiens 29-32 14612195-3 2003 We have found that neuraminidase completely abolish the inhibitory effect of ACP-1 on dopamine release, while the inhibitory activity of ACP-1 on norepinephrine release is partially lost. Norepinephrine 146-160 acid phosphatase 1 Rattus norvegicus 137-142 12761825-5 2003 LYAAT-1-IR (immunoreactivity) levels varied among different neuroanatomical structures but were present in neurons independently of the neurotransmitter used (glutamate, GABA, acetylcholine, noradrenaline, serotonin, or glycine). Norepinephrine 191-204 solute carrier family 36 member 1 Rattus norvegicus 0-7 12620813-4 2003 2-APB and heparin abolished norepinephrine (10 microM; 0 Ca2+)-evoked Ca2+ transients but increased caffeine (10 mM; 0 Ca2+) transients in fura 2-loaded myocytes. Norepinephrine 28-42 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 57-60 12620813-4 2003 2-APB and heparin abolished norepinephrine (10 microM; 0 Ca2+)-evoked Ca2+ transients but increased caffeine (10 mM; 0 Ca2+) transients in fura 2-loaded myocytes. Norepinephrine 28-42 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 70-73 12620813-4 2003 2-APB and heparin abolished norepinephrine (10 microM; 0 Ca2+)-evoked Ca2+ transients but increased caffeine (10 mM; 0 Ca2+) transients in fura 2-loaded myocytes. Norepinephrine 28-42 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 70-73 12620813-6 2003 Ca2+ sparks and transients evoked by norepinephrine and caffeine were abolished by thimerosal (100 microM), which sensitizes the IP3R to IP3. Norepinephrine 37-51 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 0-3 12889599-4 2003 Our results show that met-enkephalin, substance P, bombesin, dopamine, and norepinephrine have a stimulatory effect on the migration of the breast cancer cells; moreover, these cells show positive chemotaxis towards norepinephrine as was analyzed by the directionality and persistence on a single-cell basis. Norepinephrine 216-230 gastrin releasing peptide Homo sapiens 51-59 14499136-0 2003 Phenylephrine and norepinephrine increase dopamine transporter ligand binding in striatum. Norepinephrine 18-32 solute carrier family 6 member 3 Homo sapiens 42-62 12736175-3 2003 In the present study, we tested the hypothesis that norepinephrine (NE) is necessary for satiety induced by peripheral CCK-8 by using mice lacking dopamine beta-hydroxylase (Dbh(-/-)), the enzyme responsible for synthesizing NE and epinephrine from dopamine. Norepinephrine 52-66 cholecystokinin Mus musculus 119-122 12802495-11 2003 Obesity and a polymorphism in the perilipin gene associate with decreased protein content of perilipin and increased basal (unstrained) and noradrenaline-induced lipolysis. Norepinephrine 140-153 perilipin 1 Homo sapiens 34-43 12718440-0 2003 A mutation in the ATP7B copper transporter causes reduced dopamine beta-hydroxylase and norepinephrine in mouse adrenal. Norepinephrine 88-102 ATPase, Cu++ transporting, beta polypeptide Mus musculus 18-23 12727985-4 2003 Adipocytes of PCOS women were about 25% larger than in the controls (P < 0.05) and had 40% reduced noradrenaline-induced lipolysis (P < 0.05), which could be attributed to a 10-fold decreased beta(2)-adrenoceptor sensitivity (P < 0.05) and low ability of cAMP to activate the protein kinase A (PKA)/hormone-sensitive lipase (HSL) complex (P < 0.05). Norepinephrine 102-115 lipase E, hormone sensitive type Homo sapiens 334-337 12618215-1 2003 Noradrenaline-stimulated phosphoinositide breakdown in cultured glia was found to be mediated by alpha(1A)-adrenoceptors. Norepinephrine 0-13 calcium voltage-gated channel subunit alpha1 A Homo sapiens 97-105 12618215-2 2003 The alpha(1A)-selective agonist A61603 was as effective as noradrenaline in eliciting 3H-inositol phosphate (IP) accumulation but was approximately 50-fold more potent. Norepinephrine 59-72 calcium voltage-gated channel subunit alpha1 A Homo sapiens 4-12 12618215-3 2003 In addition, the use of selective antagonists revealed a clear rank order of potency in the ability of these drugs to reverse the effect of noradrenaline on phosphoinositide breakdown: RS17053 (alpha(1A)-selective) >>AH11110A (alpha(1B)-selective)>BMY7378 (alpha(1D)-selective). Norepinephrine 140-153 calcium voltage-gated channel subunit alpha1 A Homo sapiens 194-202 12651937-5 2003 The norepinephrine effect was blocked by the selective beta(2)-adrenoceptor antagonist, ICI 118,551, but not by pre-treatment with the selective beta(1)-adrenoceptor antagonist, atenolol. Norepinephrine 4-18 adrenoceptor beta 2 Bos taurus 55-75 12690430-13 2003 In additional experiments, designed to study the native murine beta(1)-adrenoceptor function, we used the physiological beta(1)-adrenoceptor agonist (-)-noradrenaline. Norepinephrine 149-166 adrenergic receptor, beta 1 Mus musculus 120-140 12609747-0 2003 Angiotensin II-induced release of oxytocin: interaction with norepinephrine and role in lactation. Norepinephrine 61-75 oxytocin/neurophysin I prepropeptide Homo sapiens 34-42 12609747-8 2003 These data demonstrate that Ang II evoked OT release is mediated through activation of both AT1 and AT2 receptors and suggest that a component of Ang II-induced OT stimulation is due to norepinephrine release. Norepinephrine 186-200 oxytocin/neurophysin I prepropeptide Homo sapiens 161-163 12618232-9 2003 CONCLUSION: These findings suggest that norepinephrine-induced hypertrophy is linked closely with p38 MAP kinase activation, which can be endogenously modulated through estrogen-responsive regulation of MKP-1 expression. Norepinephrine 40-54 dual specificity phosphatase 1 Mus musculus 203-208 12623961-2 2003 Furthermore, local release of atrial natriuretic peptide inhibits norepinephrine release in this nucleus, blocking local activation of alpha2-adrenergic receptors, and thereby contributes to NaCl-sensitive hypertension in spontaneously hypertensive rats. Norepinephrine 66-80 natriuretic peptide A Rattus norvegicus 30-56 12603820-2 2003 nAChR activation regulates release of various neurotransmitters, including norepinephrine (NA). Norepinephrine 75-89 cholinergic receptor nicotinic beta 1 subunit Rattus norvegicus 0-5 12591155-7 2003 Furthermore, evidence was obtained that (i) adrenaline and noradrenaline share the same binding site, and that this site would correspond to a repeated sequence present in the SCO-spondin, the major protein component of RF; and (ii) serotonin has its own binding site in RF. Norepinephrine 59-72 SCO-spondin Bos taurus 176-187 12578875-6 2003 Baseline ST2 levels were correlated with baseline B-type natriuretic peptide (BNP) levels (r=0.36, P<0.0001), baseline proatrial natriuretic peptide (ProANP) levels (r=0.36, P<0.0001), and baseline norepinephrine levels (r=0.39, P<0.0001). Norepinephrine 204-218 ST2 Homo sapiens 9-12 12538816-3 2003 In the present study, we found that norepinephrine, epinephrine, or isoproterenol down-regulated IL-18 (100 ng/ml)-induced intercellular adhesion molecule (ICAM)-1 expression on monocytes in a dose-dependent manner (10(-8)-10(-4) M), but did not effect B7.1 and B7.2 expression after 24-h incubation. Norepinephrine 36-50 interleukin 18 Homo sapiens 97-102 12538816-3 2003 In the present study, we found that norepinephrine, epinephrine, or isoproterenol down-regulated IL-18 (100 ng/ml)-induced intercellular adhesion molecule (ICAM)-1 expression on monocytes in a dose-dependent manner (10(-8)-10(-4) M), but did not effect B7.1 and B7.2 expression after 24-h incubation. Norepinephrine 36-50 intercellular adhesion molecule 1 Homo sapiens 137-163 12538816-6 2003 In the same manner, salbutanol and terbutaline as well as norepinephrine, epinephrine, and isoproterenol regulated the IL-18-induced cytokine production, including IL-12, tumor necrosis factor-alpha or interferon-gamma through the stimulation of beta 2-AR. Norepinephrine 58-72 interleukin 18 Homo sapiens 119-124 12538816-6 2003 In the same manner, salbutanol and terbutaline as well as norepinephrine, epinephrine, and isoproterenol regulated the IL-18-induced cytokine production, including IL-12, tumor necrosis factor-alpha or interferon-gamma through the stimulation of beta 2-AR. Norepinephrine 58-72 adrenoceptor beta 2 Homo sapiens 246-255 12538832-0 2003 Norepinephrine-induced stimulation of p38 mitogen-activated protein kinase is mediated by arachidonic acid metabolites generated by activation of cytosolic phospholipase A(2) in vascular smooth muscle cells. Norepinephrine 0-14 cytosolic phospholipase A2 Oryctolagus cuniculus 146-173 12482921-0 2003 CaM kinase IIalpha mediates norepinephrine-induced translocation of cytosolic phospholipase A2 to the nuclear envelope. Norepinephrine 28-42 cytosolic phospholipase A2 Oryctolagus cuniculus 68-94 12482921-1 2003 Several growth factors, hormones and neurotransmitters, including norepinephrine, increase cellular calcium levels, promoting the translocation of cytosolic phospholipase A(2) to the nuclear envelope. Norepinephrine 66-80 cytosolic phospholipase A2 Oryctolagus cuniculus 147-174 12482921-2 2003 This study was conducted to investigate the contributions of the calcium-binding protein calmodulin and of calcium-calmodulin-dependent protein kinase II to cytosolic phospholipase A(2) translocation to the nuclear envelope elicited by norepinephrine in rabbit aortic smooth-muscle cells. Norepinephrine 236-250 calmodulin Oryctolagus cuniculus 115-125 12482921-2 2003 This study was conducted to investigate the contributions of the calcium-binding protein calmodulin and of calcium-calmodulin-dependent protein kinase II to cytosolic phospholipase A(2) translocation to the nuclear envelope elicited by norepinephrine in rabbit aortic smooth-muscle cells. Norepinephrine 236-250 cytosolic phospholipase A2 Oryctolagus cuniculus 157-184 12482921-3 2003 Norepinephrine caused cytosolic phospholipase A(2) accumulation around the nuclear envelope as determined from its immunofluorescence; cytosolic phospholipase A(2) translocation was blocked by inhibitors of calmodulin and calcium-calmodulin-dependent protein kinase II or calcium-calmodulin-dependent protein kinase IIalpha antisense oligonucleotide. Norepinephrine 0-14 cytosolic phospholipase A2 Oryctolagus cuniculus 22-49 12482921-3 2003 Norepinephrine caused cytosolic phospholipase A(2) accumulation around the nuclear envelope as determined from its immunofluorescence; cytosolic phospholipase A(2) translocation was blocked by inhibitors of calmodulin and calcium-calmodulin-dependent protein kinase II or calcium-calmodulin-dependent protein kinase IIalpha antisense oligonucleotide. Norepinephrine 0-14 calmodulin Oryctolagus cuniculus 207-217 12482921-3 2003 Norepinephrine caused cytosolic phospholipase A(2) accumulation around the nuclear envelope as determined from its immunofluorescence; cytosolic phospholipase A(2) translocation was blocked by inhibitors of calmodulin and calcium-calmodulin-dependent protein kinase II or calcium-calmodulin-dependent protein kinase IIalpha antisense oligonucleotide. Norepinephrine 0-14 calmodulin Oryctolagus cuniculus 230-240 12482921-3 2003 Norepinephrine caused cytosolic phospholipase A(2) accumulation around the nuclear envelope as determined from its immunofluorescence; cytosolic phospholipase A(2) translocation was blocked by inhibitors of calmodulin and calcium-calmodulin-dependent protein kinase II or calcium-calmodulin-dependent protein kinase IIalpha antisense oligonucleotide. Norepinephrine 0-14 calmodulin Oryctolagus cuniculus 230-240 12482921-4 2003 Calmodulin and calcium-calmodulin-dependent protein kinase II inhibitors did not prevent cytosolic calcium increase but attenuated cytosolic phospholipase A(2) phosphorylation caused by norepinephrine or ionomycin. Norepinephrine 186-200 calmodulin Oryctolagus cuniculus 0-10 12482921-4 2003 Calmodulin and calcium-calmodulin-dependent protein kinase II inhibitors did not prevent cytosolic calcium increase but attenuated cytosolic phospholipase A(2) phosphorylation caused by norepinephrine or ionomycin. Norepinephrine 186-200 cytosolic phospholipase A2 Oryctolagus cuniculus 131-158 12482921-7 2003 These data suggest that norepinephrine-induced translocation of cytosolic phospholipase A(2) to the nuclear envelope is mediated by its phosphorylation by calcium-calmodulin-dependent protein kinase II and that calcium alone is insufficient for cytosolic phospholipase A(2) translocation to the nuclear envelope in rabbit vascular smooth-muscle cells. Norepinephrine 24-38 cytosolic phospholipase A2 Oryctolagus cuniculus 64-91 12482921-7 2003 These data suggest that norepinephrine-induced translocation of cytosolic phospholipase A(2) to the nuclear envelope is mediated by its phosphorylation by calcium-calmodulin-dependent protein kinase II and that calcium alone is insufficient for cytosolic phospholipase A(2) translocation to the nuclear envelope in rabbit vascular smooth-muscle cells. Norepinephrine 24-38 calmodulin Oryctolagus cuniculus 163-173 12482921-7 2003 These data suggest that norepinephrine-induced translocation of cytosolic phospholipase A(2) to the nuclear envelope is mediated by its phosphorylation by calcium-calmodulin-dependent protein kinase II and that calcium alone is insufficient for cytosolic phospholipase A(2) translocation to the nuclear envelope in rabbit vascular smooth-muscle cells. Norepinephrine 24-38 cytosolic phospholipase A2 Oryctolagus cuniculus 245-272 12488332-0 2003 Immunolesion of norepinephrine and epinephrine afferents to medial hypothalamus alters basal and 2-deoxy-D-glucose-induced neuropeptide Y and agouti gene-related protein messenger ribonucleic acid expression in the arcuate nucleus. Norepinephrine 16-30 agouti related neuropeptide Homo sapiens 142-169 12688395-4 2003 Meanwhile, activation of the alpha1b-adrenoceptor through increased interstitial noradrenaline by ischemic preconditioning is also associated with the ischemic preconditioning effect. Norepinephrine 81-94 alpha-1B adrenergic receptor Oryctolagus cuniculus 29-49 12478197-11 2003 Norepinephrine depolarized the membrane and elicited oscillatory potentials with an associated elevation in [Ca2+]. Norepinephrine 0-14 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 109-112 12478197-16 2003 Neurally released norepinephrine and ATP are increased [Ca2+] by the influx of Ca2+ through L-type Ca2+ channels and also by the release of Ca2+ from internal stores. Norepinephrine 18-32 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 56-59 12478197-16 2003 Neurally released norepinephrine and ATP are increased [Ca2+] by the influx of Ca2+ through L-type Ca2+ channels and also by the release of Ca2+ from internal stores. Norepinephrine 18-32 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 79-82 12478197-16 2003 Neurally released norepinephrine and ATP are increased [Ca2+] by the influx of Ca2+ through L-type Ca2+ channels and also by the release of Ca2+ from internal stores. Norepinephrine 18-32 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 79-82 12478197-16 2003 Neurally released norepinephrine and ATP are increased [Ca2+] by the influx of Ca2+ through L-type Ca2+ channels and also by the release of Ca2+ from internal stores. Norepinephrine 18-32 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 79-82 12585694-2 2002 We have previously reported that atrial natriuretic factor (ANF) decreases neuronal norepinephrine (NE) release. Norepinephrine 84-98 natriuretic peptide A Rattus norvegicus 33-58 12585694-2 2002 We have previously reported that atrial natriuretic factor (ANF) decreases neuronal norepinephrine (NE) release. Norepinephrine 84-98 natriuretic peptide A Rattus norvegicus 60-63 12502025-1 2002 Detection of two biogenic amine neurotransmitters, serotonin (5-HT) and norepinephrine (NE) within the CA1 region of the hippocampus (HPC) of behaving male laboratory animals (Rattus norvegicus), was performed with miniature carbon sensors (BRODERICK PROBES) and in vivo semidifferential microvoltammetry after acute administration of the soluble immune factor, human recombinant, interleukin (IL) 1alpha (10 and 100 ng/kg i.p.). Norepinephrine 72-86 carbonic anhydrase 1 Homo sapiens 103-106 12242714-1 2002 There are three subtypes of alpha2 adrenoceptor, i.e., alpha2A, alpha2B, and alpha2C, mediating the specific effect of epinephrine and norepinephrine in various tissues by means of G protein-coupled signal transduction pathways. Norepinephrine 135-149 adrenergic receptor, alpha 2c Mus musculus 77-84 12090750-9 2002 A significant correlation between protein and neurohumoral levels was exclusively found for the Na+-Ca2+ exchanger with norepinephrine (r=0.64; P=0.01). Norepinephrine 120-134 nascent polypeptide associated complex subunit alpha 2 Homo sapiens 96-103 12056750-11 2002 Neuropeptide Y is the dominating peptidergic transmitter in the testicular nerves and colocalized with noradrenaline in the same axons. Norepinephrine 103-116 pro-neuropeptide Y Camelus dromedarius 0-14 12065661-2 2002 5-HT is present in organelles distinct from l-glutamate-containing synaptic-like microvesicles as well as in the cytoplasm of pinealocytes, and is secreted upon stimulation by norepinephrine (NE) to enhance serotonin N-acetyltransferase activity via the 5-HT2 receptor. Norepinephrine 176-190 aralkylamine N-acetyltransferase Homo sapiens 207-236 11805341-0 2002 The NK1 receptor mediates both the hyperalgesia and the resistance to morphine in mice lacking noradrenaline. Norepinephrine 95-108 tachykinin receptor 1 Mus musculus 4-16 12196911-1 2002 The norepinephrine, dopamine and serotonin transporters (NET, DAT and SERT, respectively), limit cellular signaling by recapturing released neurotransmitter, and serve as targets for antidepressants and drugs of abuse, emphasizing the integral role these molecules play in neurotransmission and pathology. Norepinephrine 4-18 solute carrier family 6 member 3 Homo sapiens 62-65 11591725-8 2001 This observation correlated with a higher affinity of norepinephrine at the murine alpha(2C)- than at the alpha(2A)-receptor subtype and may explain why alpha(2C)-adrenergic receptors are especially suited to control sympathetic neurotransmission at low action potential frequencies in contrast to the alpha(2A)-receptor subtype. Norepinephrine 54-68 adrenergic receptor, alpha 2c Mus musculus 83-91 11591725-8 2001 This observation correlated with a higher affinity of norepinephrine at the murine alpha(2C)- than at the alpha(2A)-receptor subtype and may explain why alpha(2C)-adrenergic receptors are especially suited to control sympathetic neurotransmission at low action potential frequencies in contrast to the alpha(2A)-receptor subtype. Norepinephrine 54-68 adrenergic receptor, alpha 2c Mus musculus 153-161 11742865-2 2001 To investigate the signaling pathways involved in contraction, we studied the activation and regulation of p38 mitogen-activated protein kinases (p38MAPKs) and heat shock protein (HSP) kinase by endothelin and noradrenaline in rat mesenteric arteries. Norepinephrine 210-223 mitogen-activated protein kinase 11 Rattus norvegicus 146-154 11711043-8 2001 These results suggest that the activation of CRF(1) receptor may play an important role in the elevation of noradrenaline transmission, but not in 5-hydroxytriptamine transmission, in the cerebral cortex, which projects from the locus coeruleus during morphine withdrawal. Norepinephrine 108-121 corticotropin releasing hormone receptor 1 Mus musculus 45-60 11677361-5 2001 RESULTS: Increases in medial cell number and accumulation of collagen and elastin characterized norepinephrine-induced aortic remodeling. Norepinephrine 96-110 elastin Rattus norvegicus 74-81 12030814-6 2001 In the striatum, CART(62-76) decreased the levels of noradrenaline and 5-HT. Norepinephrine 53-66 CART prepropeptide Rattus norvegicus 17-21 11504796-4 2001 Clozapine (10 microM), a dopamine D(4) receptor antagonist with significant activity at adrenergic receptors, partially attenuated both dopamine and norepinephrine-induced decreases in AVP-stimulated Pf. Norepinephrine 149-163 dopamine receptor D4 Rattus norvegicus 25-47 11676206-4 2001 The present results suggest that the two endocannabinoids may oppositely participate in the CB1-receptor-mediated modulation of sympathetic norepinephrine release. Norepinephrine 140-154 cannabinoid receptor 1 Rattus norvegicus 92-95 11677796-2 2001 The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3). Norepinephrine 45-58 calcium channel, voltage-dependent, N type, alpha 1B subunit Mus musculus 190-198 11677796-2 2001 The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3). Norepinephrine 45-58 adrenergic receptor, alpha 2c Mus musculus 256-264 11677796-2 2001 The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3). Norepinephrine 45-58 hemoglobin, beta adult minor chain Mus musculus 300-314 11677796-8 2001 The release of noradrenaline from sympathetic nerves is controlled by presynaptic alpha 2A- and alpha 2C-receptors. Norepinephrine 15-28 adrenergic receptor, alpha 2c Mus musculus 96-104 11413241-1 2001 It has previously been shown that nicotine-evoked dopamine release from rat striatal synaptosomes and nicotine-evoked norepinephrine release from hippocampal synaptosomes are mediated by distinct nicotinic acetylcholine receptor (nAChR) subtypes. Norepinephrine 118-132 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 196-228 11413241-1 2001 It has previously been shown that nicotine-evoked dopamine release from rat striatal synaptosomes and nicotine-evoked norepinephrine release from hippocampal synaptosomes are mediated by distinct nicotinic acetylcholine receptor (nAChR) subtypes. Norepinephrine 118-132 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 230-235 11092898-1 2001 The norepinephrine (NET) and dopamine (DAT) transporters are highly homologous proteins, displaying many pharmacological similarities. Norepinephrine 4-18 solute carrier family 6 member 3 Homo sapiens 39-42 11258636-3 2001 At the point of exhaustion significantly higher values for norepinephrine and epinephrine were observed in ST2 than in ST1. Norepinephrine 59-73 ST2 Homo sapiens 107-110 11123297-0 2001 IFN-gamma production by Th1 cells generated from naive CD4+ T cells exposed to norepinephrine. Norepinephrine 79-93 CD4 antigen Mus musculus 55-58 11123297-1 2001 During activation in vivo, naive CD4(+) T cells are exposed to various endogenous ligands, such as cytokines and the neurotransmitter norepinephrine (NE). Norepinephrine 134-148 CD4 antigen Mus musculus 33-36 11179598-3 2001 Blockade of CRH receptors with alphah-CRF (10 microg) attenuated or blocked the BN-induced rise in plasma ACTH, epinephrine, norepinephrine, glucose and corticosterone levels. Norepinephrine 125-139 gastrin releasing peptide Homo sapiens 80-82 11100982-2 2000 We previously demonstrated that atrial natriuretic factor and B- and C-type natriuretic peptides (ANF, BNP, and CNP, respectively) modified catecholamine metabolism by increasing the neuronal uptake and decreasing the neuronal release of norepinephrine in the rat hypothalamus. Norepinephrine 238-252 natriuretic peptide A Rattus norvegicus 32-57 11100982-2 2000 We previously demonstrated that atrial natriuretic factor and B- and C-type natriuretic peptides (ANF, BNP, and CNP, respectively) modified catecholamine metabolism by increasing the neuronal uptake and decreasing the neuronal release of norepinephrine in the rat hypothalamus. Norepinephrine 238-252 natriuretic peptide A Rattus norvegicus 98-101 11196449-2 2000 Noradrenaline, octopamine and Compound A inhibited the type I DOC induced difference spectrum of P450c11 and elicited a type II difference spectrum when added alone. Norepinephrine 0-13 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 97-104 10940784-1 2000 Human adrenomedullin (AM) and human calcitonin gene-related peptide (CGRP) produced a concentration-dependent relaxation in mouse aorta, precontracted with noradrenaline. Norepinephrine 156-169 adrenomedullin Homo sapiens 6-25 10860769-0 2000 Isolation and characterization of the murine cardiotrophin-1 gene: expression and norepinephrine-induced transcriptional activation. Norepinephrine 82-96 cardiotrophin 1 Mus musculus 45-60 10860769-3 2000 In this study, we isolated and characterized the mouse CT-1 gene and studied the expression of CT-1 mRNA under norepinephrine (NE) stimulation. Norepinephrine 111-125 cardiotrophin 1 Mus musculus 95-99 10911894-0 2000 Dopamine, serotonin, and noradrenaline strongly inhibit the direct perforant path-CA1 synaptic input, but have little effect on the Schaffer collateral input. Norepinephrine 25-38 carbonic anhydrase 1 Homo sapiens 82-85 10788502-0 2000 Norepinephrine induces vascular endothelial growth factor gene expression in brown adipocytes through a beta -adrenoreceptor/cAMP/protein kinase A pathway involving Src but independently of Erk1/2. Norepinephrine 0-14 vascular endothelial growth factor A Mus musculus 23-57 10788502-2 2000 The endogenous adrenergic neurotransmitter norepinephrine (NE) induced VEGF expression 3-fold, in a dose- and time-dependent manner (EC(50) approximately 90 nm). Norepinephrine 43-57 vascular endothelial growth factor A Mus musculus 71-75 10843184-5 2000 Only nocturnal urinary norepinephrine excretion could explain a significant fraction of the variability in both UCP2 and UCP3 expression in muscle, but not adipose tissue. Norepinephrine 23-37 uncoupling protein 3 Homo sapiens 121-125 11263248-7 2000 Treatment with norepinephrine (NE) in the presence of propranolol for 24 h increased DNA synthesis in HEK293/alpha 1A- or HEK293/alpha 1B-AR cells concentration-dependently, with EC50 values of 48.8 nmol.L-1 (95% confidence limits 9.7-246 nmol.L-1) and 8.4 nmol.L-1 (95% confidence limits 2.1-32.9 nmol.L-1), respectively. Norepinephrine 15-29 calcium voltage-gated channel subunit alpha1 A Homo sapiens 109-117 11263248-7 2000 Treatment with norepinephrine (NE) in the presence of propranolol for 24 h increased DNA synthesis in HEK293/alpha 1A- or HEK293/alpha 1B-AR cells concentration-dependently, with EC50 values of 48.8 nmol.L-1 (95% confidence limits 9.7-246 nmol.L-1) and 8.4 nmol.L-1 (95% confidence limits 2.1-32.9 nmol.L-1), respectively. Norepinephrine 15-29 adrenoceptor alpha 1B Homo sapiens 129-140 10714892-8 2000 These data suggest that the alpha1A/L-adrenoceptor mediates primarily those responses to noradrenaline in this artery. Norepinephrine 89-102 calcium voltage-gated channel subunit alpha1 A Homo sapiens 28-35 11452226-9 2000 CONCLUSIONS: 1) noradrenaline has significant negative immunoregulatory effects in humans through enhancing the production of IL-10 and suppressing that of IFNgamma; and 2) the suppression of the production of IFNgamma is in part related to alpha2-adrenoceptor activation. Norepinephrine 16-29 interleukin 10 Homo sapiens 126-131 10607885-1 1999 Human alpha(1b)-adrenoceptors stably expressed (B(max) approximately 800 fmol/mg membrane protein) in mouse fibroblasts were able to increase intracellular Ca(2+) and inositol phosphate production in response to noradrenaline. Norepinephrine 212-225 calcium channel, voltage-dependent, N type, alpha 1B subunit Mus musculus 6-14 11270969-4 1999 Norepinephrine-induced increase of [Ca2+]i was inhibited by the tyrosine kinase inhibitors quercetin and tyrphostin by 23.8% and 21.4%, respectively, but the accumulation of [3H]InsPs induced by norepinephrine was not. Norepinephrine 0-14 TXK tyrosine kinase Homo sapiens 64-79 10555559-1 1999 Noradrenaline-dependent brown adipose tissue (BAT) thermogenesis is activated by the cold and excess energy intake, largely depends on the activity of the uncoupling protein 1 (UCP1), and is mediated mainly through the beta3-adrenoceptor (beta3-AR). Norepinephrine 0-13 adrenoceptor beta 3 Rattus norvegicus 219-237 10555559-1 1999 Noradrenaline-dependent brown adipose tissue (BAT) thermogenesis is activated by the cold and excess energy intake, largely depends on the activity of the uncoupling protein 1 (UCP1), and is mediated mainly through the beta3-adrenoceptor (beta3-AR). Norepinephrine 0-13 adrenoceptor beta 3 Rattus norvegicus 239-247 10494451-2 1999 We evaluated if a functional Cys23Ser polymorphism in the 5-HT2C receptor gene, the principal serotonin receptor in the brain, contributes to variation in serotonin, norepinephrine and dopamine activity, as indexed by their major metabolite concentrations in cerebrospinal fluid (CSF). Norepinephrine 166-180 5-hydroxytryptamine receptor 2C Homo sapiens 58-64 10494451-10 1999 This finding suggests that 5-HT2C receptors are involved in the regulation of norepinephrine turnover in humans; however, HTR2C Cys23Ser does not appear to contribute to the risk of alcoholism, or its contribution to this complex and heterogenous disorder is too small to be detected by a sample of this size and structure. Norepinephrine 78-92 5-hydroxytryptamine receptor 2C Homo sapiens 27-33 10559681-1 1999 We tested the hypothesis that an elevated potassium-42 ((42)K(+)) efflux (highly dependent on Ca(2+)) and an increase in the sensitivity of contraction and (42)K(+) efflux to norepinephrine (NE) in conduit arteries of aldosterone-salt hypertensive rats (AHR) extended to smaller, distributing arteries. Norepinephrine 175-189 aryl hydrocarbon receptor Rattus norvegicus 254-257 10369486-0 1999 Further characterization of the ORL1 receptor-mediated inhibition of noradrenaline release in the mouse brain in vitro. Norepinephrine 69-82 opioid receptor-like 1 Mus musculus 32-36 10369486-9 1999 In conclusion, nociceptin inhibits noradrenaline release in the mouse cortex via ORL1 receptors, which interact with presynaptic alpha2-autoreceptors on noradrenergic neurones. Norepinephrine 35-48 opioid receptor-like 1 Mus musculus 81-85 10233122-5 1999 The Tc/Tsk contribution ratio was relatively lower for thermal comfort (1:1) than for vasomotor changes (3:1; P = 0.008), metabolic heat production (3.6:1; P = 0.001), norepinephrine (1.8:1; P = 0.03), and epinephrine (3:1; P = 0.006) responses. Norepinephrine 168-182 tsukushi, small leucine rich proteoglycan Homo sapiens 7-10 10376271-5 1999 Norepinephrine also elevated [Ca2+]i in a concentration-dependent manner (202 +/- 24% over basal level at 10(-4) mol/L). Norepinephrine 0-14 carbonic anhydrase 2 Homo sapiens 30-33 10376271-7 1999 The Ca(2+)-channel antagonist nifedipine caused decrease in the [Ca2+]i response to 10(-5) mol/L of norepinephrine by 84%, whereas the [Ca2+]i rise to 10(-5) mol/L cocaine was not significantly changed. Norepinephrine 100-114 carbonic anhydrase 2 Homo sapiens 65-68 11798659-14 1999 There is evidence that it inhibits the enzymes of both 11beta-HSD2 and CYP11B2 in vasculature and leads to higher corticosterone and lower aldosterone production in vessels as well as an increase in vascular responses to norepinephrine. Norepinephrine 221-235 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 55-66 11798659-14 1999 There is evidence that it inhibits the enzymes of both 11beta-HSD2 and CYP11B2 in vasculature and leads to higher corticosterone and lower aldosterone production in vessels as well as an increase in vascular responses to norepinephrine. Norepinephrine 221-235 cytochrome P450, family 11, subfamily b, polypeptide 2 Rattus norvegicus 71-78 10435003-7 1999 Noradrenaline (NA, 1 microM) was used to stimulate beta 1-AR and isoprenaline (ISO, 1 microM) in the presence of the beta 1-AR antagonist CGP 20712A (0.1 microM) to stimulate beta 2-AR. Norepinephrine 0-13 adrenoceptor beta 2 Homo sapiens 175-184 10399886-11 1999 These results reveal that cholic acid is able to induce hypertension and provide evidence that cholic acid inhibits the transcription of both 11beta-HSD2 and CYP11B2 in vasculature, leading to lower aldosterone and higher corticosterone production in vessels and increased vasoconstrictor responses to norepinephrine. Norepinephrine 302-316 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 142-153 10399886-11 1999 These results reveal that cholic acid is able to induce hypertension and provide evidence that cholic acid inhibits the transcription of both 11beta-HSD2 and CYP11B2 in vasculature, leading to lower aldosterone and higher corticosterone production in vessels and increased vasoconstrictor responses to norepinephrine. Norepinephrine 302-316 cytochrome P450, family 11, subfamily b, polypeptide 2 Rattus norvegicus 158-165 10079004-7 1999 The results suggest that contractions evoked by noradrenaline in both muscle types of human vas deferens is mediated via activation of alpha1-adrenoceptors with pharmacological profile of the alpha1A-subtype. Norepinephrine 48-61 calcium voltage-gated channel subunit alpha1 A Homo sapiens 192-199 10437163-7 1999 CONCLUSION: Only alpha 1A-adrenoceptors mediate the norepinephrine-induced vasopressor response in perfused rat mesenteric vascular bed. Norepinephrine 52-66 calcium voltage-gated channel subunit alpha1 A Homo sapiens 17-25 10474021-10 1999 These results confirm that glycyrrhizin is able to induce hypertension, and provide evidence that it inhibits the transcriptions of both 11beta-HSD2 and CYP11B2 in the vasculature, leading to lower aldosterone and higher corticosterone production in vessels, and increased vasoconstrictor responses to norepinephrine. Norepinephrine 302-316 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 137-148 10474021-10 1999 These results confirm that glycyrrhizin is able to induce hypertension, and provide evidence that it inhibits the transcriptions of both 11beta-HSD2 and CYP11B2 in the vasculature, leading to lower aldosterone and higher corticosterone production in vessels, and increased vasoconstrictor responses to norepinephrine. Norepinephrine 302-316 cytochrome P450, family 11, subfamily b, polypeptide 2 Rattus norvegicus 153-160 10634350-7 1999 Medications with dual effects--blocking reuptake of both serotonin and norepinephrine (e.g., clomipramine and venlafaxine XR)--have superior benefits in achieving remission in major depression and GAD. Norepinephrine 71-85 glutamate decarboxylase 1 Homo sapiens 197-200 10193907-3 1999 In NAT-cells amphetamine stimulated [3H]noradrenaline efflux concentration-dependently when added to the superfusion buffer at 0.01, 0.1 and 1 microM. Norepinephrine 40-53 bromodomain containing 2 Homo sapiens 3-6 10465447-5 1999 Herein, using in situ hybridization histochemistry, we show that Nurr1 is expressed only in subset of catecholamine producing neurons (A2 partly, A8-A10 and A11 catecholaminergic cell groups), and is excluded from the norepinephrine producing neurons (A1, A2, A5-A6 catecholaminergic cell groups). Norepinephrine 218-232 nuclear receptor subfamily 4 group A member 2 Homo sapiens 65-70 9949305-11 1999 The activation of SNAT may be due to a stimulation of the sympathetic nervous system (urinary noradrenaline; NA: +243%, p < 0.005) when the cellular immune system responded towards tumor growth (urinary biopterin, +214%, p < 0.005). Norepinephrine 94-107 aralkylamine N-acetyltransferase Homo sapiens 18-22 9856972-9 1998 We conclude that there is differential regulation of PKC isoform expression by D1-like agonists that inhibits membranous PKC-delta and PKC-zeta in WKY but stimulates them in SHR; this effect in SHR is similar to the stimulatory effect of norepinephrine and angiotensin II and may be a mechanism for their differential effects on sodium transport. Norepinephrine 238-252 protein kinase C, alpha Rattus norvegicus 53-56 9792725-3 1998 Using Rat1 cells stably transfected with each of the three cloned human alpha1 adrenergic receptor subtypes, norepinephrine strongly stimulated CREB phosphorylation in alpha1A and alpha1B but more weakly in alpha1D-transfected cells. Norepinephrine 109-123 cAMP responsive element binding protein 1 Homo sapiens 144-148 9792725-3 1998 Using Rat1 cells stably transfected with each of the three cloned human alpha1 adrenergic receptor subtypes, norepinephrine strongly stimulated CREB phosphorylation in alpha1A and alpha1B but more weakly in alpha1D-transfected cells. Norepinephrine 109-123 calcium voltage-gated channel subunit alpha1 A Homo sapiens 168-175 9792725-7 1998 In addition, alpha1 adrenergic receptor-induced CREB phosphorylation was not mediated via the mitogen-activated protein kinase pathway because norepinephrine did not stimulate mitogen-activated protein kinase activity in these cells. Norepinephrine 143-157 cAMP responsive element binding protein 1 Homo sapiens 48-52 9770549-1 1998 Norepinephrine (NE) and angiotensin II (Ang II), by promoting extracellular Ca2+ influx, increase Ca2+/calmodulin-dependent kinase II (CaMKII) activity, leading to activation of mitogen-activated protein kinase (MAPK) and cytosolic phospholipase A2 (cPLA2), resulting in release of arachidonic acid (AA) for prostacyclin synthesis in rabbit vascular smooth muscle cells. Norepinephrine 0-14 cytosolic phospholipase A2 Oryctolagus cuniculus 222-248 9770549-1 1998 Norepinephrine (NE) and angiotensin II (Ang II), by promoting extracellular Ca2+ influx, increase Ca2+/calmodulin-dependent kinase II (CaMKII) activity, leading to activation of mitogen-activated protein kinase (MAPK) and cytosolic phospholipase A2 (cPLA2), resulting in release of arachidonic acid (AA) for prostacyclin synthesis in rabbit vascular smooth muscle cells. Norepinephrine 0-14 cytosolic phospholipase A2 Oryctolagus cuniculus 250-255 9756528-3 1998 Plasma epinephrine (Epi) and norepinephrine (NE) increased markedly in a dose-dependent manner for up to 120 min after intracerebroventricular or intravenous administration of aFGF (6-667 fmol/rat). Norepinephrine 29-43 fibroblast growth factor 1 Rattus norvegicus 176-180 9565624-4 1998 In HuH-7.MCAT-1 cells, L-arginine uptake was significantly up-regulated by norepinephrine and dexamethasone, and hepatocyte growth factor also increased L-arginine uptake along with cellular DNA synthesis. Norepinephrine 75-89 MIR7-3 host gene Homo sapiens 3-8 9730267-0 1998 The role of MAO-A and MAO-B in the metabolic degradation of noradrenaline in human arteries. Norepinephrine 60-73 monoamine oxidase B Homo sapiens 22-27 9523560-7 1998 The effect of IFN-alpha on [3H]noradrenaline uptake was diminished in protein kinase C-down-regulated cells. Norepinephrine 31-44 interferon alpha-A Bos taurus 14-23 9659456-1 1998 OBJECTIVES: The aims of this study were to determine (1) whether neonatal rat cardiac fibroblasts (CAFB) express P2Y receptors; (2) whether CAFB respond to extracellular ATP by inducing expression of c-fos mRNA; and (3) whether extracellular ATP modulates norepinephrine (NE)-stimulated cell growth in CAFB. Norepinephrine 256-270 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 200-205 9548402-1 1998 Role of protein kinase C. Noradrenaline increased the mRNA levels of c-fos and c-jun in rat-1 fibroblast lines stably expressing the cloned alpha1-adrenoceptor subtypes. Norepinephrine 26-39 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 69-74 9666280-0 1998 The role of norepinephrine and beta-2-adrenergic receptor stimulation in the modulation of Th1, Th2, and B lymphocyte function. Norepinephrine 12-26 negative elongation factor complex member C/D Homo sapiens 91-94 9585117-4 1998 The alpha1B-adrenoceptor subtype may be located on a space more proximal to the sympathetic nerve endings than the alpha1A-adrenoceptor subtype, because the positive inotropic effect of endogenous norepinephrine was mediated entirely by the alpha1B-adrenoceptor subtype. Norepinephrine 197-211 adrenoceptor alpha 1B Homo sapiens 4-24 9585117-4 1998 The alpha1B-adrenoceptor subtype may be located on a space more proximal to the sympathetic nerve endings than the alpha1A-adrenoceptor subtype, because the positive inotropic effect of endogenous norepinephrine was mediated entirely by the alpha1B-adrenoceptor subtype. Norepinephrine 197-211 adrenoceptor alpha 1B Homo sapiens 241-261 9403317-4 1997 Norepinephrine and epinephrine operate through differential recruitment of alpha 2- and beta-AR subtypes on the basis of their relative affinity for the different subtypes (the relative order of affinity is alpha 2 > beta 1 > or = beta 2 > beta 3 for norepinephrine). Norepinephrine 0-14 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 220-226 9299509-0 1997 Atrial natriuretic factor modifies the biosynthesis and turnover of norepinephrine in the rat adrenal medulla. Norepinephrine 68-82 natriuretic peptide A Rattus norvegicus 0-25 9299509-1 1997 In the present work we investigate atrial natriuretic factor (ANF) effects on the endogenous content, utilization and turn over of norepinephrine (NE), on tyrosine hydroxilase (TH) activity, on cAMP and cGMP levels, and on phosphatidylinositol hydrolysis in rat adrenal medulla in order to assess the possible mechanisms underlying ANF effects on NE metabolism. Norepinephrine 131-145 natriuretic peptide A Rattus norvegicus 35-60 9299509-1 1997 In the present work we investigate atrial natriuretic factor (ANF) effects on the endogenous content, utilization and turn over of norepinephrine (NE), on tyrosine hydroxilase (TH) activity, on cAMP and cGMP levels, and on phosphatidylinositol hydrolysis in rat adrenal medulla in order to assess the possible mechanisms underlying ANF effects on NE metabolism. Norepinephrine 131-145 natriuretic peptide A Rattus norvegicus 62-65 9277558-10 1997 Norepinephrine-induced constrictions were potentiated in the ET-1-injected group. Norepinephrine 0-14 endothelin-1 Sus scrofa 61-65 9487014-2 1997 Enzymes in this biosynthetic pathway, as well as those involved in the synthesis of the essential co-factor (6R)L-erythro-5,6,7,8-tetrahydrobiopterin (6-BH4) are expressed in keratinocytes producing the important hormones norepinephrine and epinephrine, which control a high beta 2-adrenoceptor density on undifferentiated/proliferating keratinocytes and the expression of alpha 1-adrenoceptors on melanocytes. Norepinephrine 222-236 adrenoceptor beta 2 Homo sapiens 275-294 9239760-5 1997 No evidence shows UTP as a synaptic transmitter; sympathetic neurons may, however, carry P2UR allowing UTP-stimulation of norepinephrine release. Norepinephrine 122-136 purinergic receptor P2Y2 Homo sapiens 89-93 9226409-6 1997 These data suggest that after extensive blockade of beta-adrenoceptors the positive inotropic effects of phenylephrine and exogenous noradrenaline result from stimulation of the alpha1A- and alpha1B-adrenoceptor subtypes, whereas that of endogenous noradrenaline is mediated via the alpha1B-adrenoceptor subtype. Norepinephrine 133-146 alpha-1B adrenergic receptor Oryctolagus cuniculus 191-211 9226409-6 1997 These data suggest that after extensive blockade of beta-adrenoceptors the positive inotropic effects of phenylephrine and exogenous noradrenaline result from stimulation of the alpha1A- and alpha1B-adrenoceptor subtypes, whereas that of endogenous noradrenaline is mediated via the alpha1B-adrenoceptor subtype. Norepinephrine 133-146 alpha-1B adrenergic receptor Oryctolagus cuniculus 283-303 9218684-6 1997 The results suggest that only alpha1A-adrenoceptors mediate the noradrenaline-induced vasopressor response in perfused rat hind limb. Norepinephrine 64-77 calcium voltage-gated channel subunit alpha1 A Homo sapiens 30-37 9166734-6 1997 The glial norepinephrine response was blocked by phentolamine but not by the removal of external Ca2+, indicating a direct activation of alpha1-adrenergic receptors that mediated release of Ca2+ from intracellular stores. Norepinephrine 10-24 carbonic anhydrase 2 Homo sapiens 190-193 9146881-0 1997 Simulatory effect of porcine insulin on noradrenaline secretion in guinea-pig ileum myenteric nerve terminals. Norepinephrine 40-53 insulin Cavia porcellus 29-36 9146881-2 1997 The effect of insulin on the release of noradrenaline (NA) from nerve terminals was investigated in isolated ileal synaptosomes of guinea-pig. Norepinephrine 40-53 insulin Cavia porcellus 14-21 9137239-13 1997 CONCLUSIONS: During sympathetic nerve stimulation, the vasoconstrictive actions of NPY are masked by norepinephrine under intact alpha-adrenoceptor conditions, manifest during alpha-blockade and modulated by KATP channel activity. Norepinephrine 101-115 neuropeptide Y Canis lupus familiaris 83-86 9092590-1 1997 Chemical signaling by dopamine (DA) and L-norepinephrine (L-NE) at synapses is terminated by uptake via specialized presynaptic transport proteins encoded by the DA transporter (DAT) and L-NE transporter (NET) genes, respectively. Norepinephrine 40-56 solute carrier family 6 member 3 Homo sapiens 178-181 9092590-1 1997 Chemical signaling by dopamine (DA) and L-norepinephrine (L-NE) at synapses is terminated by uptake via specialized presynaptic transport proteins encoded by the DA transporter (DAT) and L-NE transporter (NET) genes, respectively. Norepinephrine 58-62 solute carrier family 6 member 3 Homo sapiens 178-181 9131288-2 1997 Neuropeptide Y (NPY; 3-100 nmol/L) caused a concentration-dependent potentiation of constriction in response to noradrenaline or the thromboxane mimetic U46619 in arterioles from the submucosa of the guinea-pig small intestine. Norepinephrine 112-125 pro-neuropeptide Y Cavia porcellus 0-14 9131288-2 1997 Neuropeptide Y (NPY; 3-100 nmol/L) caused a concentration-dependent potentiation of constriction in response to noradrenaline or the thromboxane mimetic U46619 in arterioles from the submucosa of the guinea-pig small intestine. Norepinephrine 112-125 pro-neuropeptide Y Cavia porcellus 16-19 9054470-2 1997 GAL is colocalized with corticotropin (ACTH) in the human pituitary and with epinephrine (E) and norepinephrine (NE) in chromaffin cells of the adrenal medulla. Norepinephrine 97-111 galanin and GMAP prepropeptide Homo sapiens 0-3 9044380-8 1997 The results, based on these pharmacological profiles, suggest the possible involvement of alpha 3 and beta 2 nicotinic acetylcholine receptor subunits in the control of [3H]noradrenaline release from hippocampal slices. Norepinephrine 173-186 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 109-141 9034904-14 1997 The rapid induction of Fos in the piriform cortex and the locus coeruleus, taken together with previous anatomical, eletrophysiological and neurochemical studies, suggests that prolonged, excessive exposure to synaptically released acetylcholine and norepinephrine triggers the production of soman-induced seizures initially in the piriform cortex and subsequently in other cortical and subcortical structures. Norepinephrine 250-264 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 23-26 9057895-6 1997 Norepinephrine (NE)-induced pressor response was inhibited by the ChE inhibitors with the same order and magnitude as the depressor response. Norepinephrine 0-14 cholinesterase Oryctolagus cuniculus 66-69 9046014-1 1997 In vivo effects of single and repeated interferon-alpha administrations on the dynamics of noradrenaline, dopamine and 5-hydroxytryptamine were investigated in the mouse brain. Norepinephrine 91-104 interferon alpha Mus musculus 39-55 9076657-6 1997 These results suggest that NMDA receptor antagonists inhibit the increase in protein kinase activity produced by chronic morphine treatment, thus suppressing the naloxone-induced rise in norepinephrine release. Norepinephrine 187-201 KIT proto-oncogene receptor tyrosine kinase Rattus norvegicus 77-91 9039106-0 1997 Afferent and efferent arteriolar vasoconstriction to angiotensin II and norepinephrine involves release of Ca2+ from intracellular stores. Norepinephrine 72-86 carbonic anhydrase 2 Homo sapiens 107-110 8987147-3 1997 Here we present evidence that noradrenaline is released by exocytosis exclusively from the large dense cored vesicles, in which it is stored together with neuropeptide Y. Norepinephrine 30-43 neuropeptide Y Canis lupus familiaris 155-169 11243211-6 1997 This suggests that the inhibitory effects of Ber on norepinephrine, K(+)-, and H2O2-induced [Ca2+]i elevation may be one of the mechanisms against cerebral ischemia. Norepinephrine 52-66 carbonic anhydrase 2 Homo sapiens 93-96 8921799-12 1996 Norepinephrine plasmatic levels increased in both groups during CPT and exercise. Norepinephrine 0-14 choline phosphotransferase 1 Homo sapiens 64-67 8930844-5 1996 morphine infusion) alters the responsiveness of oxytocin neurones to systemic cholecystokinin (CCK), a stimulus which activates oxytocin neurones via the release of noradrenaline. Norepinephrine 165-178 cholecystokinin Rattus norvegicus 78-93 8930844-5 1996 morphine infusion) alters the responsiveness of oxytocin neurones to systemic cholecystokinin (CCK), a stimulus which activates oxytocin neurones via the release of noradrenaline. Norepinephrine 165-178 cholecystokinin Rattus norvegicus 95-98 8930940-0 1996 Acute administration of human galanin in normal subjects reduces the potentiating effect of pyridostigmine-induced cholinergic enhancement on release of norepinephrine and pancreatic polypeptide. Norepinephrine 153-167 galanin and GMAP prepropeptide Homo sapiens 30-37 8930940-2 1996 Recently we have reported that human GAL (hGAL) in man depresses the release of norepinephrine (NE) and the responses to both assumption of upright posture and insulin-induced hypoglycemia. Norepinephrine 80-94 galanin and GMAP prepropeptide Homo sapiens 37-40 8930940-2 1996 Recently we have reported that human GAL (hGAL) in man depresses the release of norepinephrine (NE) and the responses to both assumption of upright posture and insulin-induced hypoglycemia. Norepinephrine 80-94 galanin and GMAP prepropeptide Homo sapiens 42-46 8898084-2 1996 In voltage-clamp experiments with rOCT1-expressing Xenopus oocytes, superfusion with dopamine, serotonin, noradrenaline, histamine and the permanent cation acetylcholine induced saturable inwardly directed currents with apparent Km values ranging from 20 to 100 microM. Norepinephrine 106-119 solute carrier family 22 member 1 Rattus norvegicus 34-39 8905332-6 1996 Neuropeptide Y (up to 10(-4) M) did not contract any vessel; however, at 3 x 10(-7) M it shifted the frequency-response and concentration-response curves to noradrenaline in the arteries only. Norepinephrine 157-170 neuropeptide Y Canis lupus familiaris 0-14 8888009-0 1996 Inhibition of neuronal nitric oxide synthase potentiates the dimethylphenylpiperazinium-evoked carrier-mediated release of noradrenaline from rat hippocampal slices. Norepinephrine 123-136 nitric oxide synthase 1 Rattus norvegicus 14-44