PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
30238915-2	2018	Ketamine modulates several neurotransmitter systems, including norepinephrine via the norepinephrine transporter (NET), both peripherally and centrally.	Norepinephrine	63-77	solute carrier family 6 member 2	Homo sapiens	86-112
30041171-1	2018	The alpha2A-adrenoceptors (alpha2A-ARs) are Gi-coupled receptors, which prejunctionally inhibit the release of norepinephrine (NE) and epinephrine (Epi), and postjunctionally inhibit insulin secretion and lipolysis.	Norepinephrine	111-125	adrenergic receptor, alpha 2a	Mus musculus	4-11
30238915-2	2018	Ketamine modulates several neurotransmitter systems, including norepinephrine via the norepinephrine transporter (NET), both peripherally and centrally.	Norepinephrine	63-77	solute carrier family 6 member 2	Homo sapiens	114-117
30041171-1	2018	The alpha2A-adrenoceptors (alpha2A-ARs) are Gi-coupled receptors, which prejunctionally inhibit the release of norepinephrine (NE) and epinephrine (Epi), and postjunctionally inhibit insulin secretion and lipolysis.	Norepinephrine	111-125	adrenergic receptor, alpha 2a	Mus musculus	27-34
28991825-8	2017	Total concomitant vasopressor requirements, based on norepinephrine equivalents excluding vasopressin, were significantly lower at 24 hours in the renin-angiotensin-aldosterone system inhibitor group versus the non-renin-angiotensin-aldosterone system inhibitor group (10.7 vs 18.1 microg/min, respectively; p = 0.007), but no significant differences were seen at the other time points assessed.	Norepinephrine	53-67	renin	Homo sapiens	147-152
29308764-3	2018	The hypothalamus-pituitary-adrenal cortical (HPA) axis and sympathetic-adrenal medulla axis were activated and participated the initiation and progression of the stress response through the production of adrenocorticotropic hormone (ACTH), glucocorticoid (GC), epinephrine and norepinephrine (NE).	Norepinephrine	277-291	proopiomelanocortin	Homo sapiens	204-231
29308764-3	2018	The hypothalamus-pituitary-adrenal cortical (HPA) axis and sympathetic-adrenal medulla axis were activated and participated the initiation and progression of the stress response through the production of adrenocorticotropic hormone (ACTH), glucocorticoid (GC), epinephrine and norepinephrine (NE).	Norepinephrine	277-291	proopiomelanocortin	Homo sapiens	233-237
29202780-15	2017	Within the CFS group, all isoforms of TGF-beta were associated with plasma cortisol, urine norepinephrine and urine epinephrine, and this association pattern was related to fatigue score.	Norepinephrine	91-105	transforming growth factor beta 1	Homo sapiens	38-46
28888989-5	2017	Oxymetazoline was more potent and effective than noradrenaline in inducing ERK 1/2 phosphorylation.	Norepinephrine	49-62	mitogen-activated protein kinase 3	Homo sapiens	75-82
29319721-0	2017	Microcirculation improvement after short-term infusion of vasopressin in septic shock is dependent on noradrenaline.	Norepinephrine	102-115	arginine vasopressin	Homo sapiens	58-69
29319721-8	2017	The noradrenaline dose was significantly reduced after vasopressin (p=0.001) and was higher both at baseline and during vasopressin infusion in the responders than in the non-responders.	Norepinephrine	4-17	arginine vasopressin	Homo sapiens	55-66
29319721-8	2017	The noradrenaline dose was significantly reduced after vasopressin (p=0.001) and was higher both at baseline and during vasopressin infusion in the responders than in the non-responders.	Norepinephrine	4-17	arginine vasopressin	Homo sapiens	120-131
29319721-10	2017	For patients using a noradrenaline dose higher than 0.38 mcg/kg/min, the probability that microcirculatory perfusion would be improved with vasopressin was 53% (sensitivity 78%, specificity 77%).	Norepinephrine	21-34	arginine vasopressin	Homo sapiens	140-151
28675448-8	2017	COX-2 and NOS inhibitors increased noradrenaline induced vascular contractions in IMA under inflammatory conditions while no effect was observed in SV.	Norepinephrine	35-48	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-5
29319721-11	2017	CONCLUSIONS: In patients with septic shock for no longer than 48 h, administration of vasopressin is likely to result in an improvement in microcirculation when the baseline noradrenaline dose is higher than 0.38 mcg/kg/min.	Norepinephrine	174-187	arginine vasopressin	Homo sapiens	86-97
29209170-6	2017	The effect of noradrenaline depended on beta1- and not alpha1- or alpha2-adrenergic receptor stimulation.	Norepinephrine	14-27	adrenoceptor beta 1	Rattus norvegicus	40-92
28641333-4	2017	Recent findings implicate brain RAS, especially Angiotensin II (Ang II), in neural pathophysiology of mental disorders through neuroendocrine modulation and effects on neurotransmitter release, mostly noradrenaline, acetylcholine and dopamine.	Norepinephrine	201-214	angiotensinogen	Homo sapiens	64-70
28451739-2	2017	Transport of the peroxisomal enzyme D-amino acid oxidase (DAAO) appears dysregulated by specific pharmaceuticals, e.g., the anti-overactive bladder drug propiverine or a norepinephrine/serotonin reuptake inhibitor (NSRI), resulting in massive cytosolic and nuclear accumulations in rat kidney.	Norepinephrine	170-184	D-amino-acid oxidase	Rattus norvegicus	58-62
28811134-2	2017	Several neurotransmitters (e.g. serotonin, norepinephrine) are low-affinity substrates for these transporters, but possess higher affinity for other transporters (e.g. the serotonin or norepinephrine transporters; SERT and NET, respectively).	Norepinephrine	43-57	solute carrier family 6 member 4	Homo sapiens	214-218
28598954-6	2017	RESULTS: Noradrenaline treatment resulted in a pronounced increase in SGLT2 and interleukin (IL)-6 expression in HK2 cells and promoted translocation of SGLT2 to the cell surface.	Norepinephrine	9-22	interleukin 6	Mus musculus	80-98
28787643-10	2017	At 3year follow-up, elevated cTnT was related to attenuated urine norepinephrine:creatinine ratio in Blacks [OR 1.46 (95% CI 1.01-2.10); P=0.04].	Norepinephrine	66-80	troponin T2, cardiac type	Homo sapiens	29-33
28645101-0	2017	Co-localization of endogenous Arf6 and its activator EFA6D in the granular convoluted tubule cells of mouse submandibular glands under normal conditions and when stimulated by isoproterenol, noradrenaline and carbachol.	Norepinephrine	191-204	ADP-ribosylation factor 6	Mus musculus	30-34
28835457-5	2017	Noradrenaline and adrenaline dose-dependently suppressed the release of IL-27p28 in LPS/TLR4-activated macrophages, which was independent of alpha1 adrenoceptors.	Norepinephrine	0-13	toll-like receptor 4	Mus musculus	88-92
28509668-5	2017	When hypotension is refractory to norepinephrine, it is recommended adding vasopressin, which is relatively deficient during sepsis and acts on other vascular receptors than alpha1-adernergic receptors.	Norepinephrine	34-48	arginine vasopressin	Homo sapiens	75-86
28509668-9	2017	Adding vasopressin is recommended in case of shock refractory to norepinephrine.	Norepinephrine	65-79	arginine vasopressin	Homo sapiens	7-18
28319594-5	2017	During the follow-up, the reduction of anti-nAChR antibodies produced by immunoadsorption was associated with a diminished orthostatic hypotension, a restored capability to increase LF/HF, LFSAP and norepinephrine in upright position, a decline in the intensity of autonomic symptoms and an improvement of life quality.	Norepinephrine	199-213	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	44-49
28444738-7	2017	KEY RESULTS: Noradrenaline, phenylephrine, methoxamine and A61603 increased Ca2+ mobilization, cAMP accumulation and ERK1/2 phosphorylation.	Norepinephrine	13-26	mitogen-activated protein kinase 3	Homo sapiens	117-123
28630892-7	2017	Moreover, deletion of the zip-code diminished the axonal levels of dopamine (DA) and norepinephrine (NE).	Norepinephrine	85-99	sequestosome 1	Rattus norvegicus	26-29
28630432-6	2017	Norepinephrine contraction was enhanced in the corpus cavernosum of KCa2.3 T/T(+Dox) versus KCa2.3 T/T(-Dox) mice, while acetylcholine relaxation was only reduced at 0.3 microM and relaxations in response to the nitric oxide donor sodium nitroprusside were unaltered.	Norepinephrine	0-14	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	Mus musculus	68-74
28630432-6	2017	Norepinephrine contraction was enhanced in the corpus cavernosum of KCa2.3 T/T(+Dox) versus KCa2.3 T/T(-Dox) mice, while acetylcholine relaxation was only reduced at 0.3 microM and relaxations in response to the nitric oxide donor sodium nitroprusside were unaltered.	Norepinephrine	0-14	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	Mus musculus	92-98
28364364-10	2017	Based on the evidence summarized, trauma can lead to DNA methylation, as well as BNGF/NGF level increase, which in turn starts a cascade of sympathetic sprouting, leading to increased brain norepinephrine, and finally symptomatic PTSD.	Norepinephrine	190-204	nerve growth factor	Homo sapiens	81-85
27959497-0	2017	Inhibition of the Serotonin Transporter Is Altered by Metabolites of Selective Serotonin and Norepinephrine Reuptake Inhibitors and Represents a Caution to Acute or Chronic Treatment Paradigms.	Norepinephrine	93-107	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	18-39
28494751-7	2017	Droxidopa was effective in patients using inhibitors of dopa decarboxylase (DDCI; the enzyme that converts droxidopa to norepinephrine), but its efficacy was numerically greater in non-DDCI users.	Norepinephrine	120-134	dopa decarboxylase	Homo sapiens	56-74
28473352-0	2017	miR-21 is involved in norepinephrine-mediated rat granulosa cell apoptosis by targeting SMAD7.	Norepinephrine	22-36	SMAD family member 7	Rattus norvegicus	88-93
28373136-1	2017	Cyclooxygenase-2 (COX-2) induction in human internal mammary arteries (IMA) under inflammatory conditions has been associated with attenuated norepinephrine (NE)-induced vasoconstriction.	Norepinephrine	142-156	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-16
28373136-1	2017	Cyclooxygenase-2 (COX-2) induction in human internal mammary arteries (IMA) under inflammatory conditions has been associated with attenuated norepinephrine (NE)-induced vasoconstriction.	Norepinephrine	142-156	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-23
28507335-4	2017	Furthermore, this increased BNIP3L expression was confirmed in cultured neonatal rat CFs undergoing proliferation and extracellular matrix (ECM) protein over-expression that was induced by norepinephrine (NE).	Norepinephrine	189-203	BCL2 interacting protein 3 like	Rattus norvegicus	28-34
28116771-12	2017	If endothelin-1 was applied after U46619, resulting tension (172 +- 43% of KCl) significantly exceeded noradrenaline-induced contraction.	Norepinephrine	103-116	endothelin 1	Homo sapiens	3-15
28116771-16	2017	Endothelin-1 is sufficient to induce a smooth muscle tone resembling that of noradrenaline.	Norepinephrine	77-90	endothelin 1	Homo sapiens	0-12
28353077-6	2017	Moreover, upregulation of orexin signaling, in combination with elevation of epinephrine and norepinephrine circulating levels, occurs in rats exposed to chronic stress, in models of spontaneous hypertension (SHR and BPH/2J Schlager mice) and in obese mice (ob/ob or mice fed with high fat diet).	Norepinephrine	93-107	hypocretin neuropeptide precursor	Rattus norvegicus	26-32
28011264-7	2017	This inhibitory response in TNF production by exercise was mirrored by beta-AR agonists in an agonist-specific and dose-dependent manner in vitro: similar isoproterenol (EC50=2.1-4.7x10-10M) and epinephrine (EC50=4.4-10x10-10M) potency and higher norepinephrine concentrations (EC50=2.6-4.3x10-8M) needed for the effects.	Norepinephrine	247-261	tumor necrosis factor	Homo sapiens	28-31
28346464-6	2017	Following agonist stimulation and glucose infusion, endogenous insulin release inhibited lipolysis in the presence of norepinephrine, which was more rapid and pronounced in healthy obese controls than in T2D subjects (p = 0.024 obese vs T2D subjects).	Norepinephrine	118-132	insulin	Homo sapiens	63-70
28346464-13	2017	In conclusion, a difference in insulin-induced inhibition of lipolysis was observed in obese T2D subjects compared to obese healthy controls following modulation of sympathetic nervous system activity and is assumed to be due to ss1-adrenoceptor mediated stimulation by norepinephrine.	Norepinephrine	270-284	insulin	Homo sapiens	31-38
27743246-7	2017	However, the immunostaining of CgA in the tumor cells showed peculiar dot-like staining located corresponding to Golgi complex in the perinuclear area, rather than the diffuse cytoplasmic staining usually observed in epinephrine- or norepinephrine-producing functional pheochromocytomas and paragangliomas.	Norepinephrine	233-247	chromogranin A	Homo sapiens	31-34
28215131-5	2017	Calculation of a norepinephrine-equivalent vasopressor dose is critical to determining patient eligibility, as ANGII will supplement ongoing vasopressor therapy.	Norepinephrine	17-31	angiotensinogen	Homo sapiens	111-116
28137984-2	2017	Therefore, we hypothesized that TNAP regulates renovascular responsiveness to norepinephrine.	Norepinephrine	78-92	alkaline phosphatase, biomineralization associated	Rattus norvegicus	32-36
28137984-3	2017	In isolated, perfused rat kidneys, the TNAP inhibitor l-p-bromotetramisole (0.1 mmol/L) decreased renal venous levels of 5"-AMP (adenosine precursor) and adenosine by 61% (P<0.0384) and 62% (P=0.0013), respectively, at 1 hour into treatment and caused a 10-fold rightward shift of the concentration-response relationship to exogenous norepinephrine (P<0.0001).	Norepinephrine	337-351	alkaline phosphatase, biomineralization associated	Rattus norvegicus	39-43
28137984-5	2017	The ability of TNAP inhibition to blunt renovascular responses to norepinephrine was mostly prevented or reversed by restoring A1-adenosinergic tone with the A1-receptor agonist 2-chloro-N6-cyclopentyladenosine (100 nmol/L).	Norepinephrine	66-80	alkaline phosphatase, biomineralization associated	Rattus norvegicus	15-19
28137984-6	2017	All 3 TNAP inhibitors also attenuated renovascular responses to renal sympathetic nerve stimulation, suggesting that TNAP inhibition attenuates renovascular responses to endogenous norepinephrine.	Norepinephrine	181-195	alkaline phosphatase, biomineralization associated	Rattus norvegicus	117-121
28137984-8	2017	TNAP inhibitors attenuate renovascular and blood pressure responses to norepinephrine, suggesting that TNAP participates in the regulation of renal function and blood pressure.	Norepinephrine	71-85	alkaline phosphatase, biomineralization associated	Rattus norvegicus	0-4
28137984-8	2017	TNAP inhibitors attenuate renovascular and blood pressure responses to norepinephrine, suggesting that TNAP participates in the regulation of renal function and blood pressure.	Norepinephrine	71-85	alkaline phosphatase, biomineralization associated	Rattus norvegicus	103-107
27345145-4	2017	Plasma norepinephrine (NE) is often elevated in patients with POTS, resulting in consideration of dysfunction of the norepinephrine transporter (NET) encoded by SLC6A2 gene.	Norepinephrine	7-21	solute carrier family 6 member 2	Homo sapiens	117-143
27345145-4	2017	Plasma norepinephrine (NE) is often elevated in patients with POTS, resulting in consideration of dysfunction of the norepinephrine transporter (NET) encoded by SLC6A2 gene.	Norepinephrine	7-21	solute carrier family 6 member 2	Homo sapiens	161-167
28069584-0	2017	Role of norepinephrine in Abeta-related neurotoxicity: dual interactions with Tyr10 and SNK(26-28) of Abeta.	Norepinephrine	8-22	amyloid beta precursor protein	Homo sapiens	26-31
27753095-16	2017	Noradrenaline also evoked TRPC1 channel activity and associations between TRPC1, STIM1, Galphaq and PLCbeta1, which were inhibited by STIM1 knockdown.	Norepinephrine	0-13	stromal interaction molecule 1	Homo sapiens	81-86
27753095-16	2017	Noradrenaline also evoked TRPC1 channel activity and associations between TRPC1, STIM1, Galphaq and PLCbeta1, which were inhibited by STIM1 knockdown.	Norepinephrine	0-13	stromal interaction molecule 1	Homo sapiens	134-139
27923568-0	2017	Noradrenaline induces CX3CL1 production and release by neurons.	Norepinephrine	0-13	C-X3-C motif chemokine ligand 1	Homo sapiens	22-28
27923568-6	2017	In primary cortical neurons, noradrenaline induced the accumulation of CX3CL1 protein and mRNA.	Norepinephrine	29-42	C-X3-C motif chemokine ligand 1	Homo sapiens	71-77
27923568-7	2017	Noradrenaline also increased CX3CL1 in its soluble form despite the inhibition of the activity and synthesis of ADAM10 and ADAM17, the main proteases known to cleave CX3CL1 from the neuronal membrane.	Norepinephrine	0-13	C-X3-C motif chemokine ligand 1	Homo sapiens	29-35
27923568-7	2017	Noradrenaline also increased CX3CL1 in its soluble form despite the inhibition of the activity and synthesis of ADAM10 and ADAM17, the main proteases known to cleave CX3CL1 from the neuronal membrane.	Norepinephrine	0-13	C-X3-C motif chemokine ligand 1	Homo sapiens	166-172
27923568-8	2017	Noradrenaline-treated neurons displayed a higher degree of dendritic arborization and a characteristic accumulation of CX3CL1 in the dendritic bifurcation zones.	Norepinephrine	0-13	C-X3-C motif chemokine ligand 1	Homo sapiens	119-125
27923568-9	2017	The soluble CX3CL1 produced by neurons after noradrenaline treatment, reduced the accumulation of nitrites in microglia.	Norepinephrine	45-58	C-X3-C motif chemokine ligand 1	Homo sapiens	12-18
27923568-11	2017	In addition, CX3CL1 seems to be involved in the development of neuronal processes stimulated by noradrenaline.	Norepinephrine	96-109	C-X3-C motif chemokine ligand 1	Homo sapiens	13-19
28069584-0	2017	Role of norepinephrine in Abeta-related neurotoxicity: dual interactions with Tyr10 and SNK(26-28) of Abeta.	Norepinephrine	8-22	amyloid beta precursor protein	Homo sapiens	102-107
28084430-1	2017	In the present study, channelrhodopsin 2 (ChR2) was specifically introduced into murine cells expressing the Phenylethanolamine n-methyltransferase (Pnmt) gene, which encodes for the enzyme responsible for conversion of noradrenaline to adrenaline.	Norepinephrine	220-233	phenylethanolamine-N-methyltransferase	Mus musculus	109-147
27677282-7	2017	METHODS AND RESULTS: Confocal Ca2+ imaging studies on small mesenteric arteries (SMAs) from rat demonstrated that norepinephrine-induced SMC Ca2+  oscillations were inhibited by blocking IP3 receptors with xestospongin-C and by interfering with hemichannel function, most notably by the specific Cx43 hemichannel blocking peptide TAT-L2 and by TAT-CT9 that promotes Cx43 hemichannel opening.	Norepinephrine	114-128	gap junction protein, alpha 1	Rattus norvegicus	296-300
27677282-7	2017	METHODS AND RESULTS: Confocal Ca2+ imaging studies on small mesenteric arteries (SMAs) from rat demonstrated that norepinephrine-induced SMC Ca2+  oscillations were inhibited by blocking IP3 receptors with xestospongin-C and by interfering with hemichannel function, most notably by the specific Cx43 hemichannel blocking peptide TAT-L2 and by TAT-CT9 that promotes Cx43 hemichannel opening.	Norepinephrine	114-128	gap junction protein, alpha 1	Rattus norvegicus	366-370
27951473-6	2017	In anaesthetized 7-week-old male Sprague-Dawley rats, the OA (3.8 mg of intravenous injection)-induced increase in plasma noradrenaline secretion was suppressed by TRPA1 or TRPV1 antagonist and by a beta2- or beta3-adrenoceptor antagonist.	Norepinephrine	122-135	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	164-169
27951473-9	2017	These findings suggest that OA is the agonist of both TRPA1 and TRPV1 and that OA enhances UCP1 expression in IBAT with a concomitant decrease in the visceral fat mass of HF-diet-induced obese rats through enhanced noradrenaline secretion via beta-adrenergic action following TRPA1 and TRPV1 activation.	Norepinephrine	215-228	uncoupling protein 1	Rattus norvegicus	91-95
27847128-3	2017	Depending on the neuron in which they are expressed they mediate inhibition of release of NPY and of the neuron"s classical transmitter GABA, glutamate or noradrenaline, respectively.	Norepinephrine	155-168	neuropeptide Y	Rattus norvegicus	90-93
27789386-0	2017	Role of prefrontal cortical calcium-independent phospholipase A2 in antinociceptive effect of the norepinephrine reuptake inhibitor antidepresssant maprotiline.	Norepinephrine	98-112	phospholipase A2, group VI	Mus musculus	28-64
27789386-3	2017	In this study, we investigated a possible role of prefrontal cortical calcium-independent phospholipase A2 (iPLA2) in antinociception induced by the norepinephrine reuptake inhibitor (NRI) and tetracyclic (tricyclic) antidepressant, maprotiline.	Norepinephrine	149-163	phospholipase A2, group VI	Mus musculus	70-106
27789386-3	2017	In this study, we investigated a possible role of prefrontal cortical calcium-independent phospholipase A2 (iPLA2) in antinociception induced by the norepinephrine reuptake inhibitor (NRI) and tetracyclic (tricyclic) antidepressant, maprotiline.	Norepinephrine	149-163	phospholipase A2, group VI	Mus musculus	108-113
28100251-1	2017	Aromatic L-amino acid decarboxylase deficiency (AADCD) is a rare, autosomal recessive neurometabolic disorder that leads to a severe combined deficiency of serotonin, dopamine, norepinephrine and epinephrine.	Norepinephrine	177-191	dopa decarboxylase	Homo sapiens	0-35
28084430-1	2017	In the present study, channelrhodopsin 2 (ChR2) was specifically introduced into murine cells expressing the Phenylethanolamine n-methyltransferase (Pnmt) gene, which encodes for the enzyme responsible for conversion of noradrenaline to adrenaline.	Norepinephrine	220-233	phenylethanolamine-N-methyltransferase	Mus musculus	149-153
27755221-1	2016	To assess the primary metabolite of norepinephrine, 3,4-dihydroxyphenylglycol (DHPG), as a sensitive biomarker for norepinephrine transporter (NET) function and the relationship of DHPG measured peripherally and centrally, NET was antagonized with 80 mg/d atomoxetine for 18 days.	Norepinephrine	36-50	solute carrier family 6 member 2	Homo sapiens	115-141
27046647-1	2017	Norepinephrine released from sympathetic nerves is removed from the neuroeffector junction via the action of the norepinephrine transporter (NET).	Norepinephrine	0-14	solute carrier family 6 member 2	Homo sapiens	113-139
27630192-1	2017	BACKGROUND: In septic shock, the dose of norepinephrine (NE) at which vasopressin (AVP) should be added is unknown.	Norepinephrine	41-55	arginine vasopressin	Homo sapiens	70-81
27537378-9	2017	Multivariate analysis revealed that the norepinephrine level at 24-hour collected urine (24 h U-NE) and the serum creatinine level were independent determinants of %NBPF (adjusted R2 = 0.20; 24 h U-NE, p = 0.0001; serum creatinine, p = 0.04).	Norepinephrine	40-54	NBPF member 1	Homo sapiens	165-169
27237101-0	2017	Beta-adrenoceptor Activation by Norepinephrine Enhances Lipopolysaccharide-induced Matrix Metalloproteinase-9 Expression Through the ERK/JNK-c-Fos Pathway in Human THP-1 Cells.	Norepinephrine	32-46	mitogen-activated protein kinase 1	Homo sapiens	133-136
27237101-0	2017	Beta-adrenoceptor Activation by Norepinephrine Enhances Lipopolysaccharide-induced Matrix Metalloproteinase-9 Expression Through the ERK/JNK-c-Fos Pathway in Human THP-1 Cells.	Norepinephrine	32-46	mitogen-activated protein kinase 8	Homo sapiens	137-140
28508370-5	2017	Tyrosine hydroxylase, dopamine beta hydroxylase are the key enzymes for the synthesis of norepinephrine; and neuropeptide Y (NPY) is the peptide that is co-stored and co-released with norepinephrine.	Norepinephrine	89-103	tyrosine hydroxylase	Homo sapiens	0-20
28508370-5	2017	Tyrosine hydroxylase, dopamine beta hydroxylase are the key enzymes for the synthesis of norepinephrine; and neuropeptide Y (NPY) is the peptide that is co-stored and co-released with norepinephrine.	Norepinephrine	184-198	tyrosine hydroxylase	Homo sapiens	0-20
28326936-5	2017	In the formalin footpad model, systemic treatment with GCPII inhibitors reduces both phases of the inflammatory pain response and increases release of spinal noradrenaline.	Norepinephrine	158-171	folate hydrolase 1	Homo sapiens	55-60
27287619-6	2016	Spleen contraction in response to exogenous norepinephrine (NE) was found to be significantly lower in Cnr1 -/- /Cnr2 -/- mouse spleens, likely due to decreased expression of capsular alpha1AR.	Norepinephrine	44-58	cannabinoid receptor 2 (macrophage)	Mus musculus	113-117
26597684-0	2016	Norepinephrine Protects Cerebral Autoregulation and Reduces Hippocampal Necrosis after Traumatic Brain Injury via Blockade of ERK MAPK and IL-6 in Juvenile Pigs.	Norepinephrine	0-14	interleukin-6	Sus scrofa	139-143
28195064-4	2016	Using calcium microfluorimetry, the effects were evaluated by exposure to 1 muM epinephrine or 10 muM norepinephrine, alone or in the presence of adrenergic receptor inhibitors (phentolamine, prazosin and propranolol) before a 4th capsaicin application in a series of 5 consecutive capsaicin applications.	Norepinephrine	102-116	latexin	Homo sapiens	98-101
27596073-1	2016	The human dopamine, norepinephrine, and serotonin transporters (hDAT, hNET, and hSERT) are carriers of neurotransmitters and targets for many drugs.	Norepinephrine	20-34	solute carrier family 6 member 4	Homo sapiens	80-85
27651310-6	2016	Notably, clinically approved antihypertensive drugs that block L-type VDCC prevented the effects of chronic stress or norepinephrine on the IGF2/IGF-1R signaling cascade, along with transformation of lung epithelial cells and lung tumor formation.	Norepinephrine	118-132	insulin-like growth factor I receptor	Mus musculus	145-151
27491309-1	2016	Tyrosine hydroxylase (TH), which was discovered at the National Institutes of Health (NIH) in 1964, is a tetrahydrobiopterin (BH4)-requiring monooxygenase that catalyzes the first and rate-limiting step in the biosynthesis of catecholamines (CAs), such as dopamine, noradrenaline, and adrenaline.	Norepinephrine	266-279	tyrosine hydroxylase	Homo sapiens	0-20
27491309-1	2016	Tyrosine hydroxylase (TH), which was discovered at the National Institutes of Health (NIH) in 1964, is a tetrahydrobiopterin (BH4)-requiring monooxygenase that catalyzes the first and rate-limiting step in the biosynthesis of catecholamines (CAs), such as dopamine, noradrenaline, and adrenaline.	Norepinephrine	266-279	tyrosine hydroxylase	Homo sapiens	22-24
27847559-7	2016	Norepinephrine"s effect on TNFalpha production was reduced in HF (-41% +- 17% HF vs -57% +- 9% healthy, P = 0.01), and proportionately with NYHA FC.	Norepinephrine	0-14	tumor necrosis factor	Homo sapiens	27-35
27340145-1	2016	BACKGROUND: Fixed-dose vasopressin is an adjunctive therapy to norepinephrine (NE) to raise mean arterial pressure (MAP) and decrease NE requirements in patients with septic shock.	Norepinephrine	63-77	arginine vasopressin	Homo sapiens	23-34
27297082-10	2016	In conclusion, despite decreases in EF early after MI, overexpression of CuZnSOD in the MnPO was related to an improvement in left ventricular function and concomitant decreased plasma noradrenaline levels 4 weeks post MI.	Norepinephrine	185-198	superoxide dismutase 1	Rattus norvegicus	73-80
27821918-4	2016	[Results] Significant differences in norepinephrine, cortisol and blood pressure (SBP & DBP) were found in terms of interaction by time interval and between groups.	Norepinephrine	37-51	D-box binding PAR bZIP transcription factor	Homo sapiens	92-95
27146292-6	2016	Noradrenaline-induced ERK phosphorylation in Rat-1 fibroblasts expressing amino termini-truncated alpha1D-adrenoceptors.	Norepinephrine	0-13	Eph receptor B1	Rattus norvegicus	22-25
27666018-0	2016	Effect of naftopidil on brain noradrenaline-induced decrease in arginine-vasopressin secretion in rats.	Norepinephrine	30-43	arginine vasopressin	Rattus norvegicus	64-84
27391165-1	2016	BACKGROUND AND PURPOSE: 4-Methyl-N-methylcathinone (mephedrone) is a synthetic stimulant that acts as a substrate-type releaser at transporters for dopamine (DAT), noradrenaline (NET) and 5-HT (SERT).	Norepinephrine	164-177	solute carrier family 6 member 4	Rattus norvegicus	194-198
27315512-6	2016	In rats 8 weeks after SNL, increasing GLT-1 expression by histone deacetylase inhibitor valproate restored the antihypersensitivity effect of gabapentin, associated with restored gabapentin-induced noradrenergic neuronal activity in the LC and subsequent spinal noradrenaline release.	Norepinephrine	262-275	solute carrier family 1 member 2	Rattus norvegicus	38-43
26924680-1	2016	The synthesis of multiple amine neurotransmitters, such as dopamine, norepinephrine, serotonin, and trace amines, relies in part on DOPA decarboxylase (DDC, AADC), an enzyme that is required for normative neural operations.	Norepinephrine	69-83	dopa decarboxylase	Homo sapiens	132-150
26924680-1	2016	The synthesis of multiple amine neurotransmitters, such as dopamine, norepinephrine, serotonin, and trace amines, relies in part on DOPA decarboxylase (DDC, AADC), an enzyme that is required for normative neural operations.	Norepinephrine	69-83	dopa decarboxylase	Homo sapiens	152-155
26924680-1	2016	The synthesis of multiple amine neurotransmitters, such as dopamine, norepinephrine, serotonin, and trace amines, relies in part on DOPA decarboxylase (DDC, AADC), an enzyme that is required for normative neural operations.	Norepinephrine	69-83	dopa decarboxylase	Homo sapiens	157-161
27255177-2	2016	Herein, we describe our medicinal chemistry approach to discover peripheral-selective noradrenaline reuptake inhibitors to avert the risk of P-gp-mediated DDI at the blood-brain barrier.	Norepinephrine	86-99	phosphoglycolate phosphatase	Rattus norvegicus	141-145
27037808-7	2016	Both norepinephrine and dobutamine significantly reduced TNF-alpha and IL-6 production after ex vivo LPS stimulation of whole blood in a dose-dependent manner, and this effect was partially reversed by the presence of metoprolol.	Norepinephrine	5-19	tumor necrosis factor	Homo sapiens	57-66
26728293-6	2016	In contrast, intravenous noradrenaline administration mimicked CL-induced modifications of the diameter and density of pores and the elevation of portal vein IL-6 concentration.	Norepinephrine	25-38	interleukin 6	Rattus norvegicus	158-162
27271267-0	2016	Forced rather than voluntary exercise entrains peripheral clocks via a corticosterone/noradrenaline increase in PER2::LUC mice.	Norepinephrine	86-99	period circadian clock 2	Mus musculus	112-116
27207905-11	2016	Angiotensin II is known to facilitate the effects of norepinephrine, which contributes to methamphetamine"s subjective effects.	Norepinephrine	53-67	angiotensinogen	Homo sapiens	0-14
27037808-7	2016	Both norepinephrine and dobutamine significantly reduced TNF-alpha and IL-6 production after ex vivo LPS stimulation of whole blood in a dose-dependent manner, and this effect was partially reversed by the presence of metoprolol.	Norepinephrine	5-19	interleukin 6	Homo sapiens	71-75
27188854-3	2016	METHODS: In the present study, the inhibitory potential of the selective serotonin reuptake inhibitor (SSRI) and serotonin norepinephrine reuptake inhibitor (SNRI) classes of antidepressants for CYP 2D6-mediated primaquine metabolism was assessed using in vitro drug metabolism and in vivo pharmacological assays.	Norepinephrine	123-137	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	195-202
27312548-10	2016	In a conclusion, there is a relationship between the elevated expression of P2X3 receptor and P2X7 receptor in peripheral blood leukocytes and high serum epinephrine and norepinephrine levels in hyperthyroidism patients.	Norepinephrine	170-184	purinergic receptor P2X 7	Homo sapiens	94-107
26887036-7	2016	Thus, activation of CB1 receptors on sympathetic nerve terminals in bone, presumably from endocannabinoids released from apposing osteoblasts, reduces the inhibition of bone formation of sympathetic norepinephrine.	Norepinephrine	199-213	cannabinoid receptor 1	Homo sapiens	20-23
26257064-4	2016	Increased metabolites, PTGS2 and PTGES protein levels were found in Skov3-ip1 and HeyA8 cells treated with norepinephrine (NE), and these changes were shown to be mediated by ADRB2 receptor signaling.	Norepinephrine	107-121	prostaglandin-endoperoxide synthase 2	Homo sapiens	23-28
27022631-2	2016	Hcrt inputs to the locus coeruleus norepinephrine (LC NE) system and the posterior hypothalamic histaminergic tuberomammillary nuclei (TMN HA) are important efferent pathways for Hcrt-induced wakefulness.	Norepinephrine	35-49	hypocretin neuropeptide precursor	Rattus norvegicus	0-4
27556306-9	2016	Recipients who required moderate/high levels of noradrenaline for weaning off cardiopulmonary bypass were associated with lower donor concentrations of sTNFR2 (P =0.028) and IL-6 (P =0.001).	Norepinephrine	48-61	interleukin 6	Homo sapiens	174-178
26493042-8	2016	Insulin sensitivity was estimated by the Matsuda index and sympathetic nervous system activity from urinary noradrenaline excretion.	Norepinephrine	108-121	insulin	Homo sapiens	0-7
26581245-3	2016	EXPERIMENTAL DESIGN: Increased DUSP1 production by sympathetic nervous system mediators (e.g., norepinephrine) was analyzed by real-time quantitative RT-PCR and by Western blotting.	Norepinephrine	95-109	dual specificity phosphatase 1	Homo sapiens	31-36
26581245-7	2016	Genomic analyses of cells treated with norepinephrine identified DUSP1 as a potential mediator.	Norepinephrine	39-53	dual specificity phosphatase 1	Homo sapiens	65-70
26581245-10	2016	In vitro analyses indicated that norepinephrine-induced DUSP1 gene expression was mediated through ADRB2 activation of cAMP-PLC-PKC-CREB signaling, which inhibits JNK-mediated phosphorylation of c-Jun and protects ovarian cancer cells from apoptosis.	Norepinephrine	33-47	dual specificity phosphatase 1	Homo sapiens	56-61
26581245-10	2016	In vitro analyses indicated that norepinephrine-induced DUSP1 gene expression was mediated through ADRB2 activation of cAMP-PLC-PKC-CREB signaling, which inhibits JNK-mediated phosphorylation of c-Jun and protects ovarian cancer cells from apoptosis.	Norepinephrine	33-47	mitogen-activated protein kinase 8	Homo sapiens	163-166
27752611-7	2016	In the maintenance phase, the norepinephrine dose was 0.37+-0.57 and 0.26+-0.91 microg kg-1 min-1 in the 33 C and 36 C TTM groups, respectively (P<0.01).	Norepinephrine	30-44	CD59 molecule (CD59 blood group)	Homo sapiens	92-97
27752611-8	2016	During the rewarming phase, the norepinephrine and dopamine doses were 0.49+-0.60 and 9.67+-9.60 mcg kg-1 min-1 in the 33 C TTM group and 0.14+-0.46 and 3.13+-7.19 mcg kg-1 min-1 in the 36 C TTM group, respectively (P<0.01).	Norepinephrine	32-46	CD59 molecule (CD59 blood group)	Homo sapiens	106-111
26747370-1	2016	The fatty acid amide hydrolase (FAAH) inhibitor URB597 increases anandamide, resulting in antidepressant/anxiolytic-like activity, likely via CB1 receptor-mediated modulation of serotonin (5-HT) and norepinephrine (NE) neurotransmission.	Norepinephrine	199-213	fatty acid amide hydrolase	Homo sapiens	32-36
26747370-1	2016	The fatty acid amide hydrolase (FAAH) inhibitor URB597 increases anandamide, resulting in antidepressant/anxiolytic-like activity, likely via CB1 receptor-mediated modulation of serotonin (5-HT) and norepinephrine (NE) neurotransmission.	Norepinephrine	199-213	cannabinoid receptor 1	Homo sapiens	142-145
26741414-16	2016	Norepinephrine aggravated interleukin-6 upregulation in males in an extracellular signal-regulated kinase mitogen-activated protein kinase-dependent mechanism but blocked interleukin-6 up-regulation in females after fluid percussion injury.	Norepinephrine	0-14	interleukin 6	Homo sapiens	26-39
26741414-16	2016	Norepinephrine aggravated interleukin-6 upregulation in males in an extracellular signal-regulated kinase mitogen-activated protein kinase-dependent mechanism but blocked interleukin-6 up-regulation in females after fluid percussion injury.	Norepinephrine	0-14	interleukin 6	Homo sapiens	171-184
26741414-17	2016	Norepinephrine augments loss of neurons in CA1 and CA3 hippocampus of male piglets after fluid percussion injury in an extracellular signal-regulated kinase mitogen-activated protein kinase-dependent and interleukin-6-dependent manner but prevents loss of neurons in females after fluid percussion injury.	Norepinephrine	0-14	carbonic anhydrase 3	Homo sapiens	51-54
26741414-17	2016	Norepinephrine augments loss of neurons in CA1 and CA3 hippocampus of male piglets after fluid percussion injury in an extracellular signal-regulated kinase mitogen-activated protein kinase-dependent and interleukin-6-dependent manner but prevents loss of neurons in females after fluid percussion injury.	Norepinephrine	0-14	interleukin 6	Homo sapiens	204-217
26741414-18	2016	CONCLUSION: Norepinephrine protects autoregulation and limits hippocampal neuronal cell necrosis via modulation of extracellular signal-regulated kinase mitogen-activated protein kinase and interleukin-6 after fluid percussion injury in a sex-dependent manner.	Norepinephrine	12-26	interleukin 6	Homo sapiens	190-203
26661654-4	2016	We confirmed that addition of 10(-8) M ANG II to the lumen inhibited mTAL chloride transport (220 +- 19 to 165 +- 25 pmol mm(-1) min(-1), P < 0.01) and examined whether an interaction with basolateral norepinephrine existed to simulate the in vivo condition of an innervated tubule.	Norepinephrine	204-218	angiotensinogen	Rattus norvegicus	39-45
26661654-5	2016	We found that in the presence of a 10(-6) M norepinephrine bath, luminal ANG II stimulated mTAL chloride transport from 298 +- 18 to 364 +- 42 pmol mm(-1) min(-1) (P < 0.05).	Norepinephrine	44-58	angiotensinogen	Rattus norvegicus	73-79
26661654-0	2016	Luminal angiotensin II stimulates rat medullary thick ascending limb chloride transport in the presence of basolateral norepinephrine.	Norepinephrine	119-133	angiotensinogen	Rattus norvegicus	8-22
26661654-9	2016	Thus luminal ANG II increases chloride transport with basolateral norepinephrine; an effect likely mediated by stimulation of cAMP.	Norepinephrine	66-80	angiotensinogen	Rattus norvegicus	13-19
26628404-0	2016	Role of estradiol in intrinsic hindbrain AMPK regulation of hypothalamic AMPK, metabolic neuropeptide, and norepinephrine activity and food intake in the female rat.	Norepinephrine	107-121	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	41-45
26628404-1	2016	This study addressed the hypothesis that dorsomedial hindbrain adenosine 5"-monophosphate-activated protein kinase (AMPK) imposes inherent estradiol-dependent control of hypothalamic AMPK, neuropeptide, and norepinephrine (NE) activity and feeding in the female rat.	Norepinephrine	207-221	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	63-114
26628404-1	2016	This study addressed the hypothesis that dorsomedial hindbrain adenosine 5"-monophosphate-activated protein kinase (AMPK) imposes inherent estradiol-dependent control of hypothalamic AMPK, neuropeptide, and norepinephrine (NE) activity and feeding in the female rat.	Norepinephrine	207-221	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	116-120
26674707-0	2016	Polymorphism of rs3813034 in Serotonin Transporter Gene SLC6A4 Is Associated With the Selective Serotonin and Serotonin-Norepinephrine Reuptake Inhibitor Response in Depressive Disorder: Sequencing Analysis of SLC6A4.	Norepinephrine	120-134	solute carrier family 6 member 4	Homo sapiens	29-50
26674707-0	2016	Polymorphism of rs3813034 in Serotonin Transporter Gene SLC6A4 Is Associated With the Selective Serotonin and Serotonin-Norepinephrine Reuptake Inhibitor Response in Depressive Disorder: Sequencing Analysis of SLC6A4.	Norepinephrine	120-134	solute carrier family 6 member 4	Homo sapiens	56-62
26674707-0	2016	Polymorphism of rs3813034 in Serotonin Transporter Gene SLC6A4 Is Associated With the Selective Serotonin and Serotonin-Norepinephrine Reuptake Inhibitor Response in Depressive Disorder: Sequencing Analysis of SLC6A4.	Norepinephrine	120-134	solute carrier family 6 member 4	Homo sapiens	210-216
26834578-7	2015	We also immunostained for dopamine beta-hydroxylase (DBH), an enzyme critical for the conversion of dopamine to norepinephrine, to differentiate between dopaminergic and noradrenergic inputs.	Norepinephrine	112-126	dopamine beta hydroxylase	Mus musculus	26-51
26819196-7	2016	A direct effect of USF1 on BAT activation was demonstrated by an amplified adrenergic response in brown adipocytes after Usf1 silencing, and by augmented norepinephrine-induced thermogenesis in mice lacking Usf1.	Norepinephrine	154-168	upstream transcription factor 1	Mus musculus	19-23
26834578-7	2015	We also immunostained for dopamine beta-hydroxylase (DBH), an enzyme critical for the conversion of dopamine to norepinephrine, to differentiate between dopaminergic and noradrenergic inputs.	Norepinephrine	112-126	dopamine beta hydroxylase	Mus musculus	53-56
26508020-1	2016	BACKGROUND: This is a pilot study assessing the impact of polymorphisms of serotonin transporter (5-HTT; 5-HTTLPR (S/L)) and norepinephrine transporter (NET; rs2242446 (T/C)) genes on selective serotonin reuptake inhibitors (SSRIs) and serotonin/norepinephrine reuptake inhibitors (SNRIs) response in Korean panic disorder (PD) patients.	Norepinephrine	125-139	solute carrier family 6 member 2	Homo sapiens	153-156
26677330-11	2015	CONCLUSION: These results demonstrate that serum levels of interleukin-6, interleukin-8, and macrophage inflammatory protein-1beta as potential blood biomarkers could be utilized to identify the responsiveness of patients to serotonin and norepinephrine reuptake inhibitor like milnacipran, or to identify those patients who may experience AEs strong enough to warrant discontinuation of treatment.	Norepinephrine	239-253	interleukin 6	Homo sapiens	59-72
26503837-1	2015	The actions of the neurotransmitters serotonin, dopamine, and norepinephrine are partly terminated by diffusion and in part by their uptake into neurons via the selective, high-affinity transporters for serotonin (SERT), dopamine (DAT), and norepinephrine (NET), respectively.	Norepinephrine	62-76	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	231-234
27006858-1	2016	Freezing of gait (FOG) is a common disorder in Parkinson"s disease (PD) and could be attributed to a reduction in brain noradrenaline.	Norepinephrine	120-133	zinc finger protein, FOG family member 1	Homo sapiens	18-21
26546820-2	2015	Insulin secretion is controlled by metabolic stimuli (glucose, fatty acids), but also by monoamine neurotransmitters, like dopamine, serotonin, and norepinephrine.	Norepinephrine	148-162	insulin	Homo sapiens	0-7
26450532-4	2015	LC-injected GLT-1 siRNA reduced expression of GLT-1 in the LC (P=0.02), increased basal activity of LC neurons (P<0.01), and increased basal extracellular concentrations of LC glutamate (P<0.01) and spinal noradrenaline (P<0.01), but did not affect mechanical withdrawal thresholds in the hindpaw (P=0.83), compared to non-targeting siRNA.	Norepinephrine	212-225	solute carrier family 1 member 2	Rattus norvegicus	12-17
26690796-8	2015	Noradrenaline is the vasopressor of choice for preventing SAKI.	Norepinephrine	0-13	NOP2/Sun RNA methyltransferase 2	Homo sapiens	58-62
26635724-4	2015	We tested the impact of RH on amygdala function using an elevated plus-maze test of anxiety together with in vivo amygdala microdialysis for norepinephrine (NEp), a widely used marker of basolateral amygdala cognitive processes.	Norepinephrine	141-155	membrane metalloendopeptidase	Homo sapiens	157-160
26594145-5	2015	In the present study, we evaluated the effect of acute Abeta injection on norepinephrine (NE) content before and after pharmacological manipulations of nitrergic system in above mentioned areas.	Norepinephrine	74-88	amyloid beta precursor protein	Homo sapiens	55-60
26523008-8	2015	CONCLUSION: The addition of vasopressin administered concomitantly with a first-line agent (often norepinephrine) may represent the point at which the risk for pressure ulcers escalates and may be an early warning to heighten strategies to prevent pressure ulcers.	Norepinephrine	98-112	arginine vasopressin	Homo sapiens	28-39
26254859-9	2015	Depletion of descending adrenergic terminals with 6-OHDA resulted in a significant decrease in morphine efficacy in WT but not in alpha2A-KO mice, suggesting that endogenous norepinephrine acts through the alpha2A-AR to facilitate morphine antinociception.	Norepinephrine	174-188	adrenergic receptor, alpha 2a	Mus musculus	206-216
26612352-3	2015	Vasopressin can also be administered to raise mean arterial pressure or decrease the norepinephrine dose.	Norepinephrine	85-99	arginine vasopressin	Homo sapiens	0-11
26450532-5	2015	LC-injected GLT-1 siRNA impaired capsaicin-evoked release of LC glutamate and spinal noradrenaline, capsaicin-evoked LC neuronal activation, and NSIA.	Norepinephrine	85-98	solute carrier family 1 member 2	Rattus norvegicus	12-17
26398936-8	2015	Alk1(+/-) mice showed a greater hypotensive response to the beta-adrenergic antagonist atenolol and higher concentrations of epinephrine and norepinephrine in plasma than Alk1(+/+) mice.	Norepinephrine	141-155	activin A receptor, type II-like 1	Mus musculus	0-4
26374996-5	2015	Norepinephrine-mediated myocardial blood flow (MBF) was significantly enhanced in SOD2-tg mice.	Norepinephrine	0-14	superoxide dismutase 2, mitochondrial	Mus musculus	82-86
26181106-6	2015	2) Among the neurotransmitter receptors, adrenergic receptors alpha1a, alpha2a, alpha2b, and beta1 were all highly expressed, with norepinephrine and isoproterenol acting as positive regulators.	Norepinephrine	131-145	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	62-69
26181106-6	2015	2) Among the neurotransmitter receptors, adrenergic receptors alpha1a, alpha2a, alpha2b, and beta1 were all highly expressed, with norepinephrine and isoproterenol acting as positive regulators.	Norepinephrine	131-145	adrenergic receptor, alpha 2a	Mus musculus	71-78
26412054-2	2015	The drug has a high affinity for serotonin 5-HT1A and 5-HT2A receptors (5-HT1A agonist/5-HT2A antagonist) and is believed to treat HSDD by increasing levels of dopamine and noradrenaline and lowering levels of serotonin in the brain.	Norepinephrine	173-186	5-hydroxytryptamine receptor 2A	Homo sapiens	54-60
26259827-0	2015	Tph2 gene deletion enhances amphetamine-induced hypermotility: effect of 5-HT restoration and role of striatal noradrenaline release.	Norepinephrine	111-124	tryptophan hydroxylase 2	Mus musculus	0-4
26259827-3	2015	Using the in vivo microdialysis technique we found that the ability of amphetamine to stimulate noradrenaline (NA) release in the striatum was reduced by about 50% in Tph2(-/-) mice while the release of dopamine (DA) was not affected.	Norepinephrine	96-109	tryptophan hydroxylase 2	Mus musculus	167-171
26444903-7	2015	Increases in hnRNP R additionally improved AANAT production in rat pinealocytes under norepinephrine (NE) treatment.	Norepinephrine	86-100	heterogeneous nuclear ribonucleoprotein R	Rattus norvegicus	13-20
26514659-5	2015	We also studied colocalization of neuropeptide Y (NPY) in norepinephrine and epinephrine-containing neurons as NPY is a common cotransmitter with central and peripheral catecholamines.	Norepinephrine	58-72	neuropeptide Y	Rattus norvegicus	34-48
26514659-5	2015	We also studied colocalization of neuropeptide Y (NPY) in norepinephrine and epinephrine-containing neurons as NPY is a common cotransmitter with central and peripheral catecholamines.	Norepinephrine	58-72	neuropeptide Y	Rattus norvegicus	50-53
26514659-6	2015	We found significantly increased expression and coexpression of NPY in norepinephrine and epinephrine-positive neurons of locus coeruleus in SHR compared with Wistar rats.	Norepinephrine	71-85	neuropeptide Y	Rattus norvegicus	64-67
26220976-5	2015	Transmitter levels of serotonin, dopamine and norepinephrine (NE) were dysregulated from Postnatal day 7 (P7) to P21 in En2-KO, though NE exhibited the greatest abnormalities.	Norepinephrine	46-60	engrailed 2	Mus musculus	120-123
26038579-4	2015	The current study demonstrates that Ugcgf/f//CamKCreERT2 mice with genetic GCS deletion in forebrain neurons, dominantly targeting mediobasal hypothalamus (MBH), display impaired fasting-induced lipolysis accompanied by a decreased norepinephrine content in white adipose tissue (WAT).	Norepinephrine	232-246	UDP-glucose ceramide glucosyltransferase	Mus musculus	75-78
26588618-2	2015	Although activation of 5-HT-1B/1D receptors diminishes the secretion of noradrenaline from cardiac sympathetic nerves, some studies report that they may cause chest discomfort, myocardial infarction and arrhythmias due to coronary vasospasm.	Norepinephrine	72-85	5-hydroxytryptamine receptor 1B	Homo sapiens	23-30
26412054-2	2015	The drug has a high affinity for serotonin 5-HT1A and 5-HT2A receptors (5-HT1A agonist/5-HT2A antagonist) and is believed to treat HSDD by increasing levels of dopamine and noradrenaline and lowering levels of serotonin in the brain.	Norepinephrine	173-186	5-hydroxytryptamine receptor 2A	Homo sapiens	87-93
25724763-3	2015	This review summarizes the body of research focused on N/OFQ and its specific receptor, the nociceptin receptor (NOP receptor), in learning and memory, and its potential mechanisms of action, in which acetylcholine, NMDA receptor, and noradrenaline may be critical.	Norepinephrine	235-248	prepronociceptin	Homo sapiens	55-60
26136480-7	2015	In WT mice, the TRPV1 antagonist, AMG9810, caused significant hyperthermia, associated with increased noradrenaline concentrations in brown adipose tissue.	Norepinephrine	102-115	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	16-21
25628417-7	2015	Overexpression of CBS in the RVLM caused significant increases in BP, heart rate, and urinary norepinephrine excretion in SHR but not in WKY.	Norepinephrine	94-108	cystathionine beta synthase	Rattus norvegicus	18-21
26343051-3	2015	Peripheral norepinephrine release from sympathetic terminals is controlled by cannabinoid receptor type 1 (CB1), which is activated by two major endocannabinoids (ECs), arachidonylethanolamine (anandamide) and 2-arachidonylglycerol.	Norepinephrine	11-25	cannabinoid receptor 1	Homo sapiens	107-110
26116781-0	2015	In vitro ACE-inhibitory peptide KGYGGVSLPEW facilitates noradrenaline release from sympathetic nerve terminals: Relationship with the lack of antihypertensive effect on spontaneous hypertensive rats.	Norepinephrine	56-69	angiotensin I converting enzyme	Rattus norvegicus	9-12
25934568-4	2015	In addition, in situ amperometry was used to assess effects of Ang II on noradrenaline release.	Norepinephrine	73-86	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	63-69
26321956-4	2015	In human neutrophils, adrenaline and noradrenaline inhibit migration, CD11b/CD18 expression, and oxidative metabolism, possibly through beta-AR, although the role of alpha1- and alpha2-AR requires further investigation.	Norepinephrine	37-50	integrin subunit beta 2	Homo sapiens	76-80
25882827-2	2015	administered (+-)-epibatidine (1, 5 or 10 nmol/animal), a nicotinic acetylcholine receptor agonist, dose-dependently induced secretion of noradrenaline and adrenaline (catecholamines) from the rat adrenal medulla by brain diacylglycerol lipase- (DGL), monoacylglycerol lipase- (MGL) and cyclooxygenase-mediated mechanisms.	Norepinephrine	138-151	monoglyceride lipase	Rattus norvegicus	252-275
26055447-8	2015	Norepinephrine markedly increased p53 expression in endothelial cells and macrophages.	Norepinephrine	0-14	tumor protein p53	Homo sapiens	34-37
25728347-10	2015	Propranolol inhibited norepinephrine-induced cell invasion by reducing the expression of MMP-9, VEGF, and p-cofilin.	Norepinephrine	22-36	vascular endothelial growth factor A	Homo sapiens	96-100
25728347-11	2015	NO and VEGF release induced by norepinephrine was decreased by propranolol pretreatment, coincident with alterations in the phosphorylation of Akt, eNOS, and VEGFR-2.	Norepinephrine	31-45	vascular endothelial growth factor A	Homo sapiens	7-11
26290529-5	2015	In comparison with the control, angiotensin II infusion increased 24 hours urinary norepinephrine excretion, and systolic blood pressure.	Norepinephrine	83-97	angiotensinogen	Rattus norvegicus	32-46
26092866-6	2015	Supplementation with recombinant human FGF21 to alcohol-exposed FGF21 KO mice resulted in an increase in fat loss in parallel with an increase of circulating norepinephrine concentration.	Norepinephrine	158-172	fibroblast growth factor 21	Homo sapiens	39-44
26002543-3	2015	En2 knockout mice (En2-/-) display subtle cerebellar neuropathological changes and reduced levels of tyrosine hydroxylase, noradrenaline and serotonin in the hippocampus and cerebral cortex similar to those ones which have been observed in the ASD brain.	Norepinephrine	123-136	engrailed 2	Mus musculus	0-3
25882827-2	2015	administered (+-)-epibatidine (1, 5 or 10 nmol/animal), a nicotinic acetylcholine receptor agonist, dose-dependently induced secretion of noradrenaline and adrenaline (catecholamines) from the rat adrenal medulla by brain diacylglycerol lipase- (DGL), monoacylglycerol lipase- (MGL) and cyclooxygenase-mediated mechanisms.	Norepinephrine	138-151	monoglyceride lipase	Rattus norvegicus	278-281
25916722-5	2015	BNP decreased norepinephrine release from atrial preparations in response to field stimulation and also significantly reduced the heart rate responses to sympathetic nerve stimulation in vitro.	Norepinephrine	14-28	natriuretic peptide B	Rattus norvegicus	0-3
25827058-2	2015	OBJECTIVE: This study was conducted to examine the effects of pharmacological insulin sensitization on whole-body norepinephrine kinetics during a standard 75-g oral glucose tolerance test (OGTT) in obese, insulin resistant subjects with metabolic syndrome.	Norepinephrine	114-128	insulin	Homo sapiens	78-85
26207133-1	2015	OBJECTIVE: Norepinephrine is an important chemical messenger that is involved in mood and stress in humans, and is reabsorbed by the norepinephrine transporter (NET).	Norepinephrine	11-25	solute carrier family 6 member 2	Homo sapiens	133-159
26207133-1	2015	OBJECTIVE: Norepinephrine is an important chemical messenger that is involved in mood and stress in humans, and is reabsorbed by the norepinephrine transporter (NET).	Norepinephrine	11-25	solute carrier family 6 member 2	Homo sapiens	161-164
25878061-8	2015	Interestingly, in ADRA2A/TAAR1 hetero-oligomers, application of NorEpi resulted in uncoupling of the Gi/o signaling pathway, but it did not affect MAPK activation.	Norepinephrine	64-70	adrenergic receptor, alpha 2a	Mus musculus	18-24
25841321-6	2015	The ATX-induced increases in extracellular noradrenaline and dopamine levels were significantly higher in the prefrontal cortex of PACAP(-/-) mice compared to wild-type mice with C57BL/6J and 129S6/SvEvTac hybrid background.	Norepinephrine	43-56	adenylate cyclase activating polypeptide 1	Mus musculus	131-136
25878061-8	2015	Interestingly, in ADRA2A/TAAR1 hetero-oligomers, application of NorEpi resulted in uncoupling of the Gi/o signaling pathway, but it did not affect MAPK activation.	Norepinephrine	64-70	trace amine-associated receptor 1	Mus musculus	25-30
25878061-11	2015	Moreover, in ADRA2A/TAAR1 hetero-oligomers, the capacity of NorEpi to stimulate Gi/o signaling is reduced by co-stimulation with 3-T1AM.	Norepinephrine	60-66	adrenergic receptor, alpha 2a	Mus musculus	13-19
25878061-11	2015	Moreover, in ADRA2A/TAAR1 hetero-oligomers, the capacity of NorEpi to stimulate Gi/o signaling is reduced by co-stimulation with 3-T1AM.	Norepinephrine	60-66	trace amine-associated receptor 1	Mus musculus	20-25
25843793-3	2015	Although Norepinephrine (NE) can stimulate the vascular cells to produce IL-6, it is unknown whether NE induces IL-6 expression in macrophages.	Norepinephrine	9-23	interleukin 6	Homo sapiens	73-77
25820336-8	2015	The treatment with recombinant S100A8/A9 inhibited norepinephrine-induced myocyte hypertrophy and reduced the expression of calcineurin and NFATc3, but the silencing of S100A8/A9 prevented such changes.	Norepinephrine	51-65	S100 calcium binding protein A8	Rattus norvegicus	31-37
25791606-9	2015	In contrast, RT alignment of the P600 would associate it with the well-established VAN/Locus Coeruleus - Noradrenaline - Network subserving cortical reorientation.	Norepinephrine	105-118	interleukin 13	Homo sapiens	33-37
25565647-15	2015	Critically ill patients receiving more than 0.48 gamma kg min of epinephrine and/or norepinephrine at ICU admission have high I-FABP concentrations.	Norepinephrine	84-98	fatty acid binding protein 2	Homo sapiens	126-132
25972794-6	2015	Most importantly, this memory-enhancing dose of norepinephrine induced a global reduction in the acetylation levels of histone H3 at lysine 14, H2B and H4 in the IC 1 h later, whereas it had no effect on the phosphorylation of histone H3 at serine 10 or tri-methylation of histone H3 at lysine 27.	Norepinephrine	48-62	histone cluster 1, H2bg	Rattus norvegicus	144-147
25912576-3	2015	Recently, norepinephrine was reported to have a significant effect on macrophage migration by altering the expression of the chemokine receptor CCR2.	Norepinephrine	10-24	C-C motif chemokine receptor 2	Homo sapiens	144-148
25691620-5	2015	Splenic T-lymphocytes from norepinephrine-infused mice demonstrated decreased proliferation accompanied by a reduction in interferon gamma and tumor necrosis factor-alpha production as compared with T-lymphocytes from saline-infused mice.	Norepinephrine	27-41	interferon gamma	Mus musculus	122-170
25590214-0	2015	Arterial norepinephrine concentration is inversely and independently associated with insulin clearance in obese individuals with metabolic syndrome.	Norepinephrine	9-23	insulin	Homo sapiens	85-92
25590214-6	2015	In age and gender adjusted stepwise regression analyses, arterial norepinephrine concentration alone explained 19% of the variance in insulin clearance.	Norepinephrine	66-80	insulin	Homo sapiens	134-141
25590214-7	2015	When all significant variables were entered into the regression model, arterial norepinephrine, AI, gender, and M were independent predictors of insulin clearance, together explaining 41% of the variance.	Norepinephrine	80-94	insulin	Homo sapiens	145-152
25590214-8	2015	CONCLUSIONS: Arterial norepinephrine concentration is inversely and independently associated with whole-body insulin clearance rate in obese individuals with metabolic syndrome.	Norepinephrine	22-36	insulin	Homo sapiens	109-116
25903953-6	2015	There was a positive relationship between the increased adrenal mRNA expression of TH and DBH, and the high levels of circulating adrenaline and noradrenaline (all P<0.05).	Norepinephrine	145-158	TH	Sus scrofa	83-85
25617821-2	2015	In a previous study, we showed that noradrenaline (NA) microinjected into the dPAG caused a vasopressin-mediated pressor response, involving a relay in the hypothalamic paraventricular nucleus (PVN).	Norepinephrine	36-49	arginine vasopressin	Rattus norvegicus	92-103
25572399-5	2015	Here we show that epinephrine/norepinephrine regulates iron homeostasis components such as transferrin receptor-1 and ferritin-H in hepatic and skeletal muscle cells by promoting the binding of iron regulatory proteins to iron-responsive elements present in the UTRs of transferrin receptor-1 and ferritin-H transcripts.	Norepinephrine	30-44	ferritin mitochondrial	Mus musculus	118-128
25572399-5	2015	Here we show that epinephrine/norepinephrine regulates iron homeostasis components such as transferrin receptor-1 and ferritin-H in hepatic and skeletal muscle cells by promoting the binding of iron regulatory proteins to iron-responsive elements present in the UTRs of transferrin receptor-1 and ferritin-H transcripts.	Norepinephrine	30-44	ferritin mitochondrial	Mus musculus	297-307
25572399-6	2015	Increased transferrin receptor-1, decreased ferritin-H, and increased iron-responsive element-iron regulatory protein interaction are also observed in liver and muscle tissues of epinephrine/norepinephrine-injected mice.	Norepinephrine	191-205	ferritin mitochondrial	Mus musculus	44-54
25498891-9	2015	Anti-TLR4 treatment also abolished the increased vascular reactivity to noradrenaline observed in IgG-treated SHR, as described before, and inhibition of NFkappaB decreased noradrenaline responses only in IgG-treated SHR.	Norepinephrine	72-85	toll-like receptor 4	Rattus norvegicus	5-9
25637782-8	2015	A 5-day-injection of noradrenaline into the lateral ventricles produced opposite effects on the CYP isoforms.	Norepinephrine	21-34	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	96-99
25638817-8	2015	The circadian physiological variation in the spontaneous firing activity of high-firing neuronal subpopulations of both norepinephrine neurons and dorsal raphe serotonin neurons are abolished in MT1 knockout mice.	Norepinephrine	120-134	metallothionein 1	Mus musculus	195-198
25799564-9	2015	It was observed that when alpha1B-adrenergic receptors were stimulated with noradrenaline, the receptors interacted with proteins present in early endosomes, such as the early endosomes antigen 1, Rab 5, Rab 4, and Rab 11 but not with late endosome markers, such as Rab 9 and Rab 7.	Norepinephrine	76-89	RAB4A, member RAS oncogene family	Homo sapiens	204-209
25617795-10	2015	These results indicate that the selective antagonism of alpha1A- and alpha1D-adrenoceptors results in antidepressant-like effects and that the alpha1B-subtype is the main target for the increased levels of noradrenaline caused by imipramine.	Norepinephrine	206-219	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	56-63
25561369-5	2015	RESULTS: Adrenaline(A), noradrenaline and the beta-AR agonist isoprenaline reduced N-formyl-Met-Leu-Phe (fMLP)-induced migration, CD11b/CD18 expression, and ROS production, without affecting IL-8.	Norepinephrine	24-37	formyl peptide receptor 1	Homo sapiens	83-103
25561369-5	2015	RESULTS: Adrenaline(A), noradrenaline and the beta-AR agonist isoprenaline reduced N-formyl-Met-Leu-Phe (fMLP)-induced migration, CD11b/CD18 expression, and ROS production, without affecting IL-8.	Norepinephrine	24-37	formyl peptide receptor 1	Homo sapiens	105-109
25561369-5	2015	RESULTS: Adrenaline(A), noradrenaline and the beta-AR agonist isoprenaline reduced N-formyl-Met-Leu-Phe (fMLP)-induced migration, CD11b/CD18 expression, and ROS production, without affecting IL-8.	Norepinephrine	24-37	integrin subunit beta 2	Homo sapiens	136-140
25561369-5	2015	RESULTS: Adrenaline(A), noradrenaline and the beta-AR agonist isoprenaline reduced N-formyl-Met-Leu-Phe (fMLP)-induced migration, CD11b/CD18 expression, and ROS production, without affecting IL-8.	Norepinephrine	24-37	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
24810634-2	2015	At the same time noradrenaline stimulation of beta3-AR receptors increases glucose uptake solely in astrocytes.	Norepinephrine	17-30	T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3	Gallus gallus	46-51
25498891-9	2015	Anti-TLR4 treatment also abolished the increased vascular reactivity to noradrenaline observed in IgG-treated SHR, as described before, and inhibition of NFkappaB decreased noradrenaline responses only in IgG-treated SHR.	Norepinephrine	173-186	toll-like receptor 4	Rattus norvegicus	5-9
26092297-3	2015	Droxidopa, an orally active synthetic amino acid that is converted to norepinephrine by the enzyme aromatic L-amino acid decarboxylase (dopa-decarboxylase), was recently approved by the FDA for the short-term treatment of nOH.	Norepinephrine	70-84	dopa decarboxylase	Homo sapiens	99-134
24647754-7	2015	Monoamine quantification and gene expression profiling demonstrated a specific enrichment of noradrenaline only in the superficial layers of the superior colliculus of Isl2-EphA3 knock-in mice, where the retinotopy is duplicated, whereas transcript levels of receptors, transporters and metabolic enzymes of the monoaminergic pathway were not affected.	Norepinephrine	93-106	Eph receptor A3	Mus musculus	173-178
26630956-4	2015	Several FAAH or MAGL inhibitors are reported to have no cannabimimetic side effects and, therefore, are new potential therapeutic options for patients with MDD who are resistant to first-line antidepressants (selective serotonin and serotonin-norepinephrine reuptake inhibitors).	Norepinephrine	243-257	fatty acid amide hydrolase	Homo sapiens	8-12
26092297-3	2015	Droxidopa, an orally active synthetic amino acid that is converted to norepinephrine by the enzyme aromatic L-amino acid decarboxylase (dopa-decarboxylase), was recently approved by the FDA for the short-term treatment of nOH.	Norepinephrine	70-84	dopa decarboxylase	Homo sapiens	136-154
25359531-0	2015	Injection of corticotropin-releasing hormone into the amygdala aggravates visceral nociception and induces noradrenaline release in rats.	Norepinephrine	107-120	corticotropin releasing hormone	Rattus norvegicus	13-44
25655726-6	2015	Low-dose vasopressin can be added to norepinephrine to either increase the arterial blood pressure to the target goal value or decrease the norepinephrine dose, but should not be used as the initial vasopressor.	Norepinephrine	140-154	arginine vasopressin	Homo sapiens	9-20
25547633-7	2015	Reduced brain noradrenaline from LC damage is linked to amyloid-beta deposition, and tau(HYP) in the LC may seed neurofibrillary tangles in other neurons.	Norepinephrine	14-27	amyloid beta precursor protein	Homo sapiens	56-68
25175627-1	2015	Neuroblastoma is unique amongst common pediatric cancers for its expression of the norepinephrine transporter (NET), enabling tumor-selective imaging and therapy with radioactive analogues of norepinephrine.	Norepinephrine	83-97	solute carrier family 6 member 2	Homo sapiens	111-114
25359531-3	2015	Here, we verified the hypothesis that CRH in the CeA sensitizes visceral nociception via CRH-R1 with release of noradrenaline, dopamine, and serotonin (5-HT) in the CeA.	Norepinephrine	112-125	corticotropin releasing hormone	Rattus norvegicus	38-41
25359531-9	2015	Noradrenaline in the CeA was increased by CRD, further increased by CRH, and inhibited by CRH-R1 antagonist.	Norepinephrine	0-13	corticotropin releasing hormone	Rattus norvegicus	68-71
25359531-12	2015	CONCLUSIONS & INFERENCES: These results suggest that CRH in the CeA sensitizes visceral nociception via CRH-R1 with release of noradrenaline.	Norepinephrine	131-144	corticotropin releasing hormone	Rattus norvegicus	57-60
25584932-4	2015	Black and Hispanic populations are known to have a higher prevalence of cardiovascular risk factors and disease, and a substantial proportion of black and Hispanic individuals possess genotypes of the cytochrome P450 (CYP) 2C9 enzyme involved in the metabolism of many NSAIDs and the CYP2D6 enzyme involved in metabolism of the dual opioid agonist/norepinephrine-serotonin reuptake inhibitor tramadol.	Norepinephrine	348-362	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	284-290
25017001-2	2014	The authors tested the hypothesis that C-reactive protein (CRP), a commonly available marker of systemic inflammation, predicts differential response to escitalopram (a serotonin reuptake inhibitor) and nortriptyline (a norepinephrine reuptake inhibitor).	Norepinephrine	220-234	C-reactive protein	Homo sapiens	39-57
25928910-0	2015	Neuropeptide Y as a presynaptic modulator of norepinephrine release from the sympathetic nerve fibers in the pig pineal gland.	Norepinephrine	45-59	neuropeptide Y	Sus scrofa	0-14
25002345-1	2014	This research is aimed to discover the influence and underling mechanism of combined infusion of arginine vasopressin with levosimendan on acute lung injury in rat septic shock with norepinephrine supplemented.	Norepinephrine	182-196	arginine vasopressin	Rattus norvegicus	106-117
25002345-3	2014	It is observed that the combined infusion supplemented with norepinephrine brought about a lower mean pulmonary artery pressure; lower high-mobility group box 1 levels, pulmonary levels of interleukin-6, and arterial total nitrate/nitrite; lower apoptotic cells scores and total histological scores; but higher pulmonary gas exchange when compared with the separate infusion group and norepinephrine group.	Norepinephrine	60-74	interleukin 6	Rattus norvegicus	189-202
25017001-2	2014	The authors tested the hypothesis that C-reactive protein (CRP), a commonly available marker of systemic inflammation, predicts differential response to escitalopram (a serotonin reuptake inhibitor) and nortriptyline (a norepinephrine reuptake inhibitor).	Norepinephrine	220-234	C-reactive protein	Homo sapiens	59-62
25402186-4	2014	In the present study, using immunodetection methods, we revealed the presence of several proteins important for the dopamine uptake and signalling in mammalian sperm, specifically monoamine transporters as dopamine (DAT), serotonin (SERT) and norepinephrine (NET) transporters in equine sperm.	Norepinephrine	243-257	solute carrier family 6 member 4	Homo sapiens	222-231
25286297-4	2014	Cases refractory to first-line vasopressors (norepinephrine) will require second-line vasopressors (epinephrine or vasopressin) and low-dose steroid therapy.	Norepinephrine	45-59	arginine vasopressin	Homo sapiens	115-126
25239924-7	2014	The AT1AR catecholaminergic knockout mice had decreased renal fluid and electrolyte retention and urinary noradrenaline excretion.	Norepinephrine	106-119	angiotensin II receptor, type 1a	Mus musculus	4-9
25225185-5	2014	In the locus coeruleus, brexpiprazole reversed the inhibitory effect of the preferential 5-HT2A receptor agonist DOI (2,5-dimethoxy-4-iodoamphetamine) on norepinephrine neuronal firing (ED50 = 110 mug/kg), demonstrating 5-HT2A antagonistic action.	Norepinephrine	154-168	5-hydroxytryptamine receptor 2A	Homo sapiens	89-104
25225185-5	2014	In the locus coeruleus, brexpiprazole reversed the inhibitory effect of the preferential 5-HT2A receptor agonist DOI (2,5-dimethoxy-4-iodoamphetamine) on norepinephrine neuronal firing (ED50 = 110 mug/kg), demonstrating 5-HT2A antagonistic action.	Norepinephrine	154-168	5-hydroxytryptamine receptor 2A	Homo sapiens	89-95
25402186-4	2014	In the present study, using immunodetection methods, we revealed the presence of several proteins important for the dopamine uptake and signalling in mammalian sperm, specifically monoamine transporters as dopamine (DAT), serotonin (SERT) and norepinephrine (NET) transporters in equine sperm.	Norepinephrine	243-257	solute carrier family 6 member 4	Homo sapiens	233-237
25161169-2	2014	The aim of this study was to characterize beta-adrenoceptor-mediated relaxation and facilitation of norepinephrine release in the aorta of phenylethanolamine-N-methyltransferase-knockout (Pnmt-KO) mice.	Norepinephrine	100-114	phenylethanolamine-N-methyltransferase	Mus musculus	139-177
25376904-4	2014	RESULTS: In the present study we investigated insulin-dependent mitochondrial Ca(2+) signaling in normal and norepinephrine or insulin like growth factor-1-induced hypertrophic cardiomyocytes.	Norepinephrine	109-123	insulin	Homo sapiens	46-53
25376904-9	2014	Blocking mitochondrial Ca(2+) uptake was sufficient to mimic the effect of norepinephrine-induced cardiomyocyte hypertrophy on insulin signaling.	Norepinephrine	75-89	insulin	Homo sapiens	127-134
25378171-10	2014	Knockdown of endogenous BLA-miR-19b levels resulted in opposite behavioral and noradrenergic profile with higher freezing time and increase 3-methoxy-4-hydroxyphenylglycol/noradrenaline ratio.	Norepinephrine	172-185	microRNA 19b-2	Mus musculus	28-35
25303896-10	2014	Droxidopa is a synthetic amino acid that is converted to norepinephrine by dopa-decarboxylase, the same enzyme that converts levodopa into dopamine in the treatment of Parkinson disease.	Norepinephrine	57-71	dopa decarboxylase	Homo sapiens	75-93
25100382-8	2014	CONCLUSION: We conclude that selective serotonin-norepinephrine reuptake inhibitors (SNRIs) can cause symptoms suggestive of serotonin-secreting neuroendocrine neoplasms, as well as elevated CA levels leading to unnecessary and expensive diagnostic workups.	Norepinephrine	49-63	chromogranin A	Homo sapiens	191-193
25049229-6	2014	The bioluminescence resonance energy transfer signal exhibited a biphasic response to norepinephrine concentration, suggesting that GRK2 is recruited to Gbetagamma and alpha(2A)AR with EC50 values of 15 nM and 8 muM, respectively.	Norepinephrine	86-100	G protein-coupled receptor kinase 2	Homo sapiens	132-136
25295552-4	2014	Response to venlafaxine was assessed after 4 weeks of treatment and correlated to serum concentration and functional variants in genes encoding the norepinephrine (SLC6A2; rs28386840) and the serotonin transporter (SLC6A4; [5-HTTLPR], rs25531).	Norepinephrine	148-162	solute carrier family 6 member 2	Homo sapiens	164-170
24965872-0	2014	Cardiac-targeting magnetic lipoplex delivery of SH-IGF1R plasmid attenuate norepinephrine-induced cardiac hypertrophy in murine heart.	Norepinephrine	75-89	insulin-like growth factor I receptor	Mus musculus	51-56
24965872-8	2014	These results suggested that liposomal magnetofection-mediated IGF1R-specific-shRNA may be a promising method, and suppression the IGF1R expression inhibited norepinephrine-induced cardiac hypertrophic process via inhibiting PI3K (phosphoinositide 3-kinase)/AKT pathway.	Norepinephrine	158-172	insulin-like growth factor I receptor	Mus musculus	131-136
24965872-8	2014	These results suggested that liposomal magnetofection-mediated IGF1R-specific-shRNA may be a promising method, and suppression the IGF1R expression inhibited norepinephrine-induced cardiac hypertrophic process via inhibiting PI3K (phosphoinositide 3-kinase)/AKT pathway.	Norepinephrine	158-172	thymoma viral proto-oncogene 1	Mus musculus	258-261
25205295-0	2014	Inhibition of a TREK-like K+ channel current by noradrenaline requires both beta1- and beta2-adrenoceptors in rat atrial myocytes.	Norepinephrine	48-61	adrenoceptor beta 1	Rattus norvegicus	76-106
25179535-3	2014	In this study, we showed that the neurotransmitter norepinephrine upregulated VEGF (VEGFA) expression in breast cancer cells and that the culture supernatant from norepinephrine-treated breast cancer cells promoted the formation of the capillary-like network of endothelial cells.	Norepinephrine	51-65	vascular endothelial growth factor A	Homo sapiens	78-82
25179535-3	2014	In this study, we showed that the neurotransmitter norepinephrine upregulated VEGF (VEGFA) expression in breast cancer cells and that the culture supernatant from norepinephrine-treated breast cancer cells promoted the formation of the capillary-like network of endothelial cells.	Norepinephrine	51-65	vascular endothelial growth factor A	Homo sapiens	84-89
25179535-3	2014	In this study, we showed that the neurotransmitter norepinephrine upregulated VEGF (VEGFA) expression in breast cancer cells and that the culture supernatant from norepinephrine-treated breast cancer cells promoted the formation of the capillary-like network of endothelial cells.	Norepinephrine	163-177	vascular endothelial growth factor A	Homo sapiens	78-82
25179535-3	2014	In this study, we showed that the neurotransmitter norepinephrine upregulated VEGF (VEGFA) expression in breast cancer cells and that the culture supernatant from norepinephrine-treated breast cancer cells promoted the formation of the capillary-like network of endothelial cells.	Norepinephrine	163-177	vascular endothelial growth factor A	Homo sapiens	84-89
25179535-7	2014	Inhibitors of beta2-adrenergic receptor (beta2-AR), protein kinase A (PKA), and mTOR could reverse norepinephrine-induced Jagged 1 upregulation, indicating that the beta2-AR-PKA-mTOR pathway participates in this process.	Norepinephrine	99-113	mechanistic target of rapamycin kinase	Homo sapiens	80-84
25179535-7	2014	Inhibitors of beta2-adrenergic receptor (beta2-AR), protein kinase A (PKA), and mTOR could reverse norepinephrine-induced Jagged 1 upregulation, indicating that the beta2-AR-PKA-mTOR pathway participates in this process.	Norepinephrine	99-113	mechanistic target of rapamycin kinase	Homo sapiens	178-182
25179535-9	2014	These data demonstrate that tumor angiogenesis mediated by the Jagged 1/Notch intercellular signaling is governed by the norepinephrine-activated beta2-AR-PKA-mTOR pathway.	Norepinephrine	121-135	mechanistic target of rapamycin kinase	Homo sapiens	159-163
24886880-7	2014	Moreover, the leftward shift of the noradrenaline curves promoted by uptake blockers (cocaine and corticosterone) and beta-adrenoceptor antagonist (propranolol) was reduced in the vas deferens of treated group.	Norepinephrine	36-49	arginine vasopressin	Rattus norvegicus	180-183
25018040-6	2014	Further, we found that norepinephrine increased the frequency of spontaneous excitatory postsynaptic currents (sEPSCs) on RLi dopamine neurons.	Norepinephrine	23-37	ATP-binding cassette, sub-family E (OABP), member 1	Mus musculus	122-125
24937541-2	2014	OBJECTIVE: The objective of the study was to test the hypotheses that pharmacological improvement in insulin sensitivity would (1) attenuate sympathetic neural drive and (2) enhance neuronal norepinephrine uptake.	Norepinephrine	191-205	insulin	Homo sapiens	101-108
24658683-13	2014	Furthermore, norepinephrine uptake of myocardium may be ameliorated by suppressing aldosterone production after standard treatment containing intravenous ANP.	Norepinephrine	13-27	natriuretic peptide A	Homo sapiens	154-157
24799612-8	2014	Because the 2 protein kinases, STE20p-related proline- and alanine-rich kinase (encoded by STK39) and oxidative stress-response kinase 1, phosphorylate and activate NCC, we examined their roles in norepinephrine effects.	Norepinephrine	197-211	serine/threonine kinase 24	Mus musculus	31-37
24737484-2	2014	The present study sought to further investigate the functional effects of histamine on the neuronal and exogenous noradrenaline-induced contraction of the testicular capsule and rat vas deferens as well as to evaluate the contractile properties of this drug.	Norepinephrine	114-127	arginine vasopressin	Rattus norvegicus	182-185
24737484-6	2014	Histamine was able to decrease the tonic response for noradrenaline-induced contractions with participation of H1 receptors (testicular capsule) and H3 receptors (vas deferens) followed by nitric oxide generation.	Norepinephrine	54-67	arginine vasopressin	Rattus norvegicus	163-166
24858852-11	2014	EPC exposure to epinephrine or norepinephrine showed negative dose-response relationships on cell adhesion to fibronectin and collagen; both catecholamines stimulated early EPC growth, but epinephrine inhibited late EPC growth.	Norepinephrine	31-45	fibronectin 1	Homo sapiens	110-121
25075188-3	2014	Its combined action on SERT and four subtypes of serotoninergic receptors increases the extracellular concentration of serotonin, dopamine, and noradrenaline.	Norepinephrine	144-157	solute carrier family 6 member 4	Homo sapiens	23-27
24469435-2	2014	Carvedilol is known to block pre-junctional beta2-adrenoceptor responsible for norepinephrine release.	Norepinephrine	79-93	beta-2 adrenergic receptor	Canis lupus familiaris	44-62
25221588-3	2014	In turn, noradrenaline may act on up-regulated alpha1-adrenoceptors to increase the production of the pro-inflammatory cytokine interleukin-6.	Norepinephrine	9-22	interleukin 6	Homo sapiens	128-141
24641259-7	2014	The up-regulation of Cx43 was not monoamine-related since noradrenaline, 5-HT and dopamine did not induce Cx43 expression and pretreatment with alpha- and beta-adrenoceptor antagonists had no effect.	Norepinephrine	58-71	gap junction protein, alpha 1	Rattus norvegicus	21-25
24657150-1	2014	We recently reported that intracerebroventricularly administered 2-arachidonoylglycerol elevated plasma noradrenaline and adrenaline by brain monoacylglycerol lipase- (MGL) and cyclooxygenase-mediated mechanisms in the rat.	Norepinephrine	104-117	monoglyceride lipase	Rattus norvegicus	142-165
24657150-1	2014	We recently reported that intracerebroventricularly administered 2-arachidonoylglycerol elevated plasma noradrenaline and adrenaline by brain monoacylglycerol lipase- (MGL) and cyclooxygenase-mediated mechanisms in the rat.	Norepinephrine	104-117	monoglyceride lipase	Rattus norvegicus	168-171
24657150-2	2014	These results suggest that 2-arachidonoylglycerol is hydrolyzed by MGL to free arachidonic acid, which is further metabolized to prostaglandins (PGs) by cyclooxygenase in the brain, thereby elevating plasma noradrenaline and adrenaline.	Norepinephrine	207-220	monoglyceride lipase	Rattus norvegicus	67-70
24657150-7	2014	The PGE2-G-induced elevation of plasma noradrenaline was attenuated by JZL184 (MGL inhibitor).	Norepinephrine	39-52	monoglyceride lipase	Rattus norvegicus	79-82
24838480-5	2014	Based on the published study results vasopressin appears to be of potential benefit in adult patients with moderate septic shock (norepinephrine requirements < 15 mug/min) and lacking signs of systemic hypoperfusion (e.g. normal arterial lactate levels).	Norepinephrine	130-144	arginine vasopressin	Homo sapiens	37-48
24162233-5	2014	Noradrenaline-induced contraction and Ca(2+) signal were significantly depressed in MLCK-siRNA compared to scramble-siRNA-transfected RMA.	Norepinephrine	0-13	myosin light chain kinase	Rattus norvegicus	84-88
24495399-8	2014	Selective blockade by the dihydrokainic acid or knock-down of GLT-1 by the small interfering RNA abolished the gabapentin-induced glutamate increase in the LC, whereas blockade of GABA-B receptors by the CGP-35348 and depletion of noradrenalin by the dopamine-beta-hydroxylase antibody conjugated to saporin did not.	Norepinephrine	231-243	solute carrier family 1 member 2	Rattus norvegicus	62-67
24697908-6	2014	RESULTS: ET-1 (10(-10)  M) enhanced EFS-induced vasoconstriction, and treatment with the adrenergic neurotoxin guanethidine reduced the contractions induced by ET-1 in penile arteries from both LZRs and OZRs, thus supporting the hypothesis that ET-1 releases noradrenaline from adrenergic nerves.	Norepinephrine	259-272	endothelin 1	Rattus norvegicus	160-164
24697908-6	2014	RESULTS: ET-1 (10(-10)  M) enhanced EFS-induced vasoconstriction, and treatment with the adrenergic neurotoxin guanethidine reduced the contractions induced by ET-1 in penile arteries from both LZRs and OZRs, thus supporting the hypothesis that ET-1 releases noradrenaline from adrenergic nerves.	Norepinephrine	259-272	endothelin 1	Rattus norvegicus	160-164
24796498-4	2014	Vasodilation induced by G-1 (selective GPER-agonist, 3 muM) from HRAs pre-contracted with norepinephrine amounted to 40+-5% in PMW, significantly larger than those obtained from M (20+-5%) or PGW (20+-5%).	Norepinephrine	90-104	latexin	Homo sapiens	55-58
24155262-3	2014	Epinephrine is synthesized from norepinephrine by the enzyme phenylethanolamine N-methyltransferase (PNMT) and works as an endogenous adrenoceptor ligand secreted peripherally by the adrenal medulla.	Norepinephrine	32-46	phenylethanolamine-N-methyltransferase	Mus musculus	61-99
24417771-2	2014	Tyrosine hydroxylase (TH) is the rate-limiting enzyme for the biosynthesis of catecholamine, including dopamine and noradrenaline.	Norepinephrine	116-129	tyrosine hydroxylase	Homo sapiens	0-20
24417771-2	2014	Tyrosine hydroxylase (TH) is the rate-limiting enzyme for the biosynthesis of catecholamine, including dopamine and noradrenaline.	Norepinephrine	116-129	tyrosine hydroxylase	Homo sapiens	22-24
24852170-2	2014	Here we demonstrate that the pheromonal signals detected by Gr32a-expressing chemosensory neurons to enhance male aggression are filtered through octopamine (OA, invertebrate equivalent of norepinephrine) neurons.	Norepinephrine	189-203	Gustatory receptor 32a	Drosophila melanogaster	60-65
24440144-4	2014	Furthermore, noradrenaline (NA), the main sympathetic neurotransmitter, induced apoptosis in B6- and lpr/lpr-derived Tregs.	Norepinephrine	13-26	Fas (TNF receptor superfamily member 6)	Mus musculus	93-104
24440144-4	2014	Furthermore, noradrenaline (NA), the main sympathetic neurotransmitter, induced apoptosis in B6- and lpr/lpr-derived Tregs.	Norepinephrine	13-26	Fas (TNF receptor superfamily member 6)	Mus musculus	101-104
24155262-3	2014	Epinephrine is synthesized from norepinephrine by the enzyme phenylethanolamine N-methyltransferase (PNMT) and works as an endogenous adrenoceptor ligand secreted peripherally by the adrenal medulla.	Norepinephrine	32-46	phenylethanolamine-N-methyltransferase	Mus musculus	101-105
24554716-0	2014	Growth differentiation factor (GDF)-15 blocks norepinephrine-induced myocardial hypertrophy via a novel pathway involving inhibition of epidermal growth factor receptor transactivation.	Norepinephrine	46-60	epidermal growth factor receptor	Homo sapiens	136-168
24516103-9	2014	The vasodilator response to substance P was unaffected by sitagliptin and enalaprilat; however, substance P increased heart rate and vascular release of norepinephrine during combined ACE and dipeptidyl peptidase-4 inhibition.	Norepinephrine	153-167	tachykinin precursor 1	Homo sapiens	96-107
24516103-9	2014	The vasodilator response to substance P was unaffected by sitagliptin and enalaprilat; however, substance P increased heart rate and vascular release of norepinephrine during combined ACE and dipeptidyl peptidase-4 inhibition.	Norepinephrine	153-167	angiotensin I converting enzyme	Homo sapiens	184-187
24554716-3	2014	In this present study, we demonstrate that GDF-15 blocks norepinephrine (NE)-induced myocardial hypertrophy through a novel pathway involving inhibition of EGFR transactivation.	Norepinephrine	57-71	epidermal growth factor receptor	Homo sapiens	156-160
24452243-11	2014	As Agtrap and Agtr1b not only participate in the "uptake of norepinephrine" and "blood pressure", but also in the "behavior" of SHRSP at 6 weeks of age, our data demonstrate a close association between hypertension and ADHD.	Norepinephrine	60-74	angiotensin II receptor, type 1b	Rattus norvegicus	14-20
24374096-4	2014	Moreover, noradrenaline increased REDD1 mRNA expression at doses higher than the effective doses of adrenaline.	Norepinephrine	10-23	DNA-damage-inducible transcript 4	Mus musculus	34-39
24263237-14	2014	CONCLUSIONS: The unique molecular pharmacological profile of dezocine as a partial mu-receptor agonist, a kappa-receptor antagonist, and a norepinephrine and serotonin reuptake inhibitor (via norepinephrine transporter and serotonin transporter) was revealed.	Norepinephrine	139-153	solute carrier family 6 member 2	Homo sapiens	192-218
24573553-2	2014	Although the norepinephrine analog, meta-iodobenzylguanidine (MIBG), is an established substrate for NET, (123)I/(131)I-MIBG has several clinical limitations for diagnostic imaging.	Norepinephrine	13-27	solute carrier family 6 member 2	Homo sapiens	101-104
23225134-8	2014	In peripheral regions, angiotensin II elevates both norepinephrine release and synthesis and inhibits norepinephrine uptake at nerve endings, which may contribute to the increase in sympathetic nerve activity seen in chronic heart failure.	Norepinephrine	52-66	angiotensinogen	Homo sapiens	23-37
23225134-8	2014	In peripheral regions, angiotensin II elevates both norepinephrine release and synthesis and inhibits norepinephrine uptake at nerve endings, which may contribute to the increase in sympathetic nerve activity seen in chronic heart failure.	Norepinephrine	102-116	angiotensinogen	Homo sapiens	23-37
24251585-1	2014	BACKGROUND AND PURPOSE: Amphetamines bind to the plasmalemmal transporters for the monoamines dopamine (DAT), noradrenaline (NET) and 5-HT (SERT); influx of amphetamine leads to efflux of substrates.	Norepinephrine	110-123	solute carrier family 6 member 4	Homo sapiens	140-144
24583830-6	2014	Our results suggest that cold air exposure increases blood pressure in cardiovascular disease patients and healthy subjects via the sympathetic nervous system (SNS) that is activated first and which augments ANG-II levels accelerating the release of the norepinephrine and stimulates the renin-angiotensin system (RAS).	Norepinephrine	254-268	angiotensinogen	Homo sapiens	208-214
24374096-1	2014	In the present study, we examined the effect of stress-related catecholamines adrenaline and noradrenaline on macrophage expression of a new host defense factor REDD1 using murine macrophage cell line RAW264.7 and murine peritoneal macrophages.	Norepinephrine	93-106	DNA-damage-inducible transcript 4	Mus musculus	161-166
24499533-8	2014	Patients received vasoactive support with (mean +- standard deviation, SD) 0.57 +- 0.49 mug   kg-1   min-1 norepinephrine resulting in a mean arterial pressure of 103 +- 13 mmHg and a systemic vascular resistance of 943 +- 248 dyn   s   cm-5.	Norepinephrine	107-121	CD59 molecule (CD59 blood group)	Homo sapiens	101-106
23736373-12	2014	During BA differentiation, FGF21 gene expression and secretion were increased, and were augmented following norepinephrine exposure (a cold mimic in vitro).	Norepinephrine	108-122	fibroblast growth factor 21	Homo sapiens	27-32
24519125-0	2014	Stress-related hormone norepinephrine induces interleukin-6 expression in GES-1 cells.	Norepinephrine	23-37	interleukin 6	Homo sapiens	46-59
24519125-3	2014	However, the precise mechanism of IL-6 induction by the stress-related hormone norepinephrine (NE) is not clear, and, furthermore, there are no reports about the effect of NE on IL-6 expression in gastric epithelial cells.	Norepinephrine	79-93	interleukin 6	Homo sapiens	34-38
24519125-8	2014	The results suggest that chronic stress may increase IL-6 secretion of human gastric epithelial cells, at least in part, by the stress-associated hormone norepinephrine, and provides basic data on stress and gastric cancer progression.	Norepinephrine	154-168	interleukin 6	Homo sapiens	53-57
23736373-14	2014	Treatment of WA with FGF21-induced UCP1 expression and increased oxygen consumption, respiratory uncoupling, norepinephrine-mediated thermogenesis, fatty acid oxidation and heat production, thus recapitulating the association between cold-induced FGF21 secretion and cold-induced thermogenesis in vivo.	Norepinephrine	109-123	fibroblast growth factor 21	Homo sapiens	21-26
23085509-5	2014	The pro-inflammatory cytokine interferon-gamma stimulates the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4), which is a co-factor for several aromatic amino acid mono-oxygenases and is rate-limiting for the biosynthesis of the neurotransmitter serotonin and the catecholamines dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline).	Norepinephrine	320-334	interferon gamma	Homo sapiens	30-46
24304472-0	2014	alpha1 adrenoceptor activation by norepinephrine inhibits LPS-induced cardiomyocyte TNF-alpha production via modulating ERK1/2 and NF-kappaB pathway.	Norepinephrine	34-48	tumor necrosis factor	Rattus norvegicus	84-93
24304472-2	2014	This study was designed to observe the effect of norepinephrine (NE) on lipopolysaccharide (LPS)-induced cardiomyocyte TNF-alpha expression and to further investigate the underlying mechanisms in neonatal rat cardiomyocytes and endotoxaemic mice.	Norepinephrine	49-63	tumor necrosis factor	Rattus norvegicus	119-128
24121204-2	2014	The norepinephrine transporter (NET) regulates the synaptic availability of norepinephrine.	Norepinephrine	4-18	solute carrier family 6 member 2	Homo sapiens	32-35
24465756-2	2014	In addition to the importance of hha in positive regulation of motility, a two-component quorum sensing pathway encoded by the qseBC genes has been shown to activate bacterial motility in response to mammalian stress hormones epinephrine and norepinephrine as well as bacterially produced autoinducer-3.	Norepinephrine	242-256	anosmin 1	Homo sapiens	33-36
23085509-5	2014	The pro-inflammatory cytokine interferon-gamma stimulates the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4), which is a co-factor for several aromatic amino acid mono-oxygenases and is rate-limiting for the biosynthesis of the neurotransmitter serotonin and the catecholamines dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline).	Norepinephrine	336-349	interferon gamma	Homo sapiens	30-46
24762451-9	2014	Two studies have showed that FFA3 activation by SCFAs increases firing and norepinephrine (NE) release from sympathetic neurons.	Norepinephrine	75-89	free fatty acid receptor 3	Homo sapiens	29-33
23688012-3	2014	EGFR is activated not only by its multiple peptide ligands but also by many other factors including angiotensin II, endothelin-1, norepinephrine, thrombin and prorenin; the phenomenon referred to as "transactivation".	Norepinephrine	130-144	epidermal growth factor receptor	Homo sapiens	0-4
25230230-4	2014	This reaction is considered as rate-limiting step in the biosynthesis of catecholamines, dopamine, norepinephrine and epinephrine, which has made TH an important target for drug development.	Norepinephrine	99-113	tyrosine hydroxylase	Homo sapiens	146-148
25366910-3	2014	We have found that noxious mechanical and thermal stimuli to the skin increase the release of substance P and somatostatin, respectively, from the dorsal horn in situ, and that noradrenaline inhibits the release of substance P and glutamate from primary afferents.	Norepinephrine	177-190	tachykinin precursor 1	Homo sapiens	215-226
24297249-1	2014	We found previously that stimulation of natriuretic peptide receptor (NPR)-B by C-type natriuretic peptide (CNP) in failing rat ventricle potentiates beta1-adrenoceptor (beta1-AR)-mediated inotropic response to noradrenaline through cGMP-mediated inhibition of phosphodiesterase (PDE) 3, thereby enhancing cAMP-mediated signalling.	Norepinephrine	211-224	adrenoceptor beta 1	Rattus norvegicus	150-168
24297249-1	2014	We found previously that stimulation of natriuretic peptide receptor (NPR)-B by C-type natriuretic peptide (CNP) in failing rat ventricle potentiates beta1-adrenoceptor (beta1-AR)-mediated inotropic response to noradrenaline through cGMP-mediated inhibition of phosphodiesterase (PDE) 3, thereby enhancing cAMP-mediated signalling.	Norepinephrine	211-224	adrenoceptor beta 1	Rattus norvegicus	170-178
24297249-9	2014	We identified several small molecule NPR-B antagonists by high throughput screening and show in a functional heart preparation that blocking NPR-B stimulation with a small molecule compound can reduce the potentiating effect of CNP on the beta1-AR-mediated inotropic response to noradrenaline.	Norepinephrine	279-292	adrenoceptor beta 1	Rattus norvegicus	239-247
24642449-5	2014	However, the copresence of LPS and either epinephrine or norepinephrine resulted in a strong M2 phenotype including high levels of arginase-1 and interleukin-10, and a reduced expression of M1 markers.	Norepinephrine	57-71	interleukin 10	Mus musculus	146-160
24366986-1	2014	OBJECTIVE: Vitamin B12 is involved in the production of adrenaline from noradrenaline.	Norepinephrine	72-85	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	19-22
24391727-8	2013	RESULTS: Norepinephrine secretion rose across eGFR tertiles while eGFR fell (p<0.0001).	Norepinephrine	9-23	epidermal growth factor receptor	Homo sapiens	46-50
24027106-8	2013	In astroglial cultures, ADPbetaS and UDP increased norepinephrine uptake mainly by activation of P2Y1 and P2Y6 receptors, respectively.	Norepinephrine	51-65	purinergic receptor P2Y1	Rattus norvegicus	97-101
24391727-10	2013	Since dopamine beta-hydroxylase (DBH) catalyzes conversion of dopamine to norepinephrine, we studied functional variation at DBH; DBH promoter haplotypes predicted transcriptional activity (p<0.001), plasma DBH (p<0.0001) and norepinephrine (p = 0.0297) secretion; transcriptional activity was inversely (p<0.0001) associated with basal eGFR.	Norepinephrine	74-88	epidermal growth factor receptor	Homo sapiens	346-350
24157129-3	2013	Upon showing that prepubertal orchidectomy augmented the efficacy of thymopoiesis through increasing the thymocyte surface density of Thy-1, whose expression is negatively regulated by beta2-AR-mediated signaling, we examined the effects of orchidectomy and 14-day-long propranolol (PROP) treatment in orchidectomized (ORX) and sham-ORX rats on thymic norepinephrine (NE) concentration and metabolism and beta2-AR expression.	Norepinephrine	352-366	Thy-1 cell surface antigen	Rattus norvegicus	134-139
24479719-3	2013	Norepinephrine and other adrenoceptor agonists are known to provoke activation of proinflammatory cytokines such as interleukin (IL)-1 and IL-6.	Norepinephrine	0-14	interleukin 6	Homo sapiens	139-143
24295263-6	2013	RESULTS: Endothelin 1, oxytocin, prostaglandin F2alpha, norepinephrine, and phenylephrine induced dose-dependent contraction of the isolated urethral tissue, whereas acetylcholine, carbachol, and angiotensin II had no or only minor contractile effects.	Norepinephrine	56-70	angiotensinogen	Homo sapiens	196-210
24051022-0	2013	Spinal-supraspinal and intrinsic mu-opioid receptor agonist-norepinephrine reuptake inhibitor (MOR-NRI) synergy of tapentadol in diabetic heat hyperalgesia in mice.	Norepinephrine	60-74	opioid receptor, mu 1	Mus musculus	95-98
24026137-0	2013	Norepinephrine and adenosine-5"-triphosphate synergize in inducing IL-6 production by human dermal microvascular endothelial cells.	Norepinephrine	0-14	interleukin 6	Homo sapiens	67-71
24194850-0	2013	Ang II enhances noradrenaline release from sympathetic nerve endings thus contributing to the up-regulation of metalloprotease-2 in aortic dissection patients" aorta wall.	Norepinephrine	16-29	angiotensinogen	Homo sapiens	0-6
23740369-8	2013	Stress hormones such as norepinephrine have been shown to cause upregulation of cytokines such as Interleukin 6 and 8, which are proangiogenic and support tumour progression.	Norepinephrine	24-38	interleukin 6	Homo sapiens	98-117
23871390-8	2013	CONCLUSIONS: The opposite trends in VEGF levels, increasing in ER and decreasing in ENR, might reflect differential Norepinephrine/Serotonin effects of duloxetine on differential neurobiological backgrounds of depressive syndromes.	Norepinephrine	116-130	vascular endothelial growth factor A	Homo sapiens	36-40
24194850-1	2013	OBJECT: To test the hypothesis that angiotensin II (Ang II) could enhance noradrenaline (NA) release from sympathetic nerve endings of the aorta thus contributing to the up-regulation of matrix metalloproteinase 2 (MMP-2) during the formation of aortic dissection (AD).	Norepinephrine	74-87	angiotensinogen	Homo sapiens	36-50
24194850-1	2013	OBJECT: To test the hypothesis that angiotensin II (Ang II) could enhance noradrenaline (NA) release from sympathetic nerve endings of the aorta thus contributing to the up-regulation of matrix metalloproteinase 2 (MMP-2) during the formation of aortic dissection (AD).	Norepinephrine	74-87	angiotensinogen	Homo sapiens	52-58
23718987-12	2013	These data suggest that in CRPS, norepinephrine released from sympathetic nerve terminals stimulates beta2-ARs expressed on epidermal keratinocytes, resulting in local IL-6 production, and ultimately, pain sensitization.	Norepinephrine	33-47	interleukin 6	Rattus norvegicus	168-172
23948306-2	2013	The norepinephrine effects are mediated through G-protein-coupled receptors; further mediation of such stimulation to e.g. Erk1/2 activation is in cell biology in general accepted to occur through transactivation of the EGF receptor (by external or internal pathways).	Norepinephrine	4-18	mitogen-activated protein kinase 3	Homo sapiens	123-129
23948306-8	2013	AG1478 action on EGF-stimulated Erk1/2 phosphorylation showed a sharp concentration-response relationship (IC50 0.3microM); a minor apparent effect of AG1478 on norepinephrine-stimulated Erk1/2 phosphorylation showed nonspecific kinetics, implying caution in interpretation of partial effects of AG1478 as reported in other systems.	Norepinephrine	161-175	mitogen-activated protein kinase 3	Homo sapiens	187-193
24099434-2	2013	Lower heart rates, higher arterial pressures, and fewer norepinephrine doses during vasopressin therapy were hypothesized to protect the heart from myocardial ischemia.	Norepinephrine	56-70	arginine vasopressin	Homo sapiens	84-95
23797785-7	2013	We investigated TGM-2 crosslinking of several biogenic amines (serotonin, histamine, dopamine and noradrenaline) to fibrinogen.	Norepinephrine	98-111	transglutaminase 2	Homo sapiens	16-21
23797785-7	2013	We investigated TGM-2 crosslinking of several biogenic amines (serotonin, histamine, dopamine and noradrenaline) to fibrinogen.	Norepinephrine	98-111	fibrinogen beta chain	Homo sapiens	116-126
24108336-4	2013	Several purines and peptides have been postulated as neurotransmitters of this system, and some of them coexist with the acetylcholine or norepinephrine; for example, vasoactive intestinal peptide (VIP) on cholinergic nerves and neuropeptide Y in the adrenergic nerves.	Norepinephrine	138-152	vasoactive intestinal peptide	Homo sapiens	167-196
24108336-4	2013	Several purines and peptides have been postulated as neurotransmitters of this system, and some of them coexist with the acetylcholine or norepinephrine; for example, vasoactive intestinal peptide (VIP) on cholinergic nerves and neuropeptide Y in the adrenergic nerves.	Norepinephrine	138-152	vasoactive intestinal peptide	Homo sapiens	198-201
23921203-10	2013	Multiple endocrine neoplasia type 2- and NF1-related PCC samples exhibited both adrenaline and noradrenaline secretion.	Norepinephrine	95-108	neurofibromin 1	Homo sapiens	41-44
23976952-7	2013	GNTI enhanced calcium mobilization by noradrenaline at the alpha(1A)-adrenoceptor (EC50 = 41 nM), but did not activate the receptor, displace radioligands, or enhance PI hydrolysis.	Norepinephrine	38-51	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	0-4
23714242-10	2013	Current study suggests that norepinephrine inhibits synthesis of Bcl-2 and increases Bax and apoptosis of cardiomyocytes.	Norepinephrine	28-42	BCL2, apoptosis regulator	Rattus norvegicus	65-70
24358443-0	2013	Elevated plasma norepinephrine inhibits insulin secretion, but adrenergic blockade reveals enhanced beta-cell responsiveness in an ovine model of placental insufficiency at 0.7 of gestation.	Norepinephrine	16-30	insulin	Homo sapiens	40-47
23808809-2	2013	The aim of the present investigation was to evaluate the effect of noradrenaline (NA) on the release of IL-1beta, IL-6 and TNFalpha by macrophages from ObZ, as well as the effect of habitual exercise (running, 5days/week for 35 min at 35cm/s for 14week); all of them using lean Zucker rats (Fa/fa) (LZ) as reference values.	Norepinephrine	67-80	interleukin 1 beta	Rattus norvegicus	104-112
23808809-2	2013	The aim of the present investigation was to evaluate the effect of noradrenaline (NA) on the release of IL-1beta, IL-6 and TNFalpha by macrophages from ObZ, as well as the effect of habitual exercise (running, 5days/week for 35 min at 35cm/s for 14week); all of them using lean Zucker rats (Fa/fa) (LZ) as reference values.	Norepinephrine	67-80	tumor necrosis factor	Rattus norvegicus	123-131
23716582-6	2013	In normoxic animals, both SKCa channel opener NS309 and a large-conductance (BKCa) channel opener NS1619 relaxed norepinephrine-contracted uterine arteries in pregnant but not nonpregnant sheep.	Norepinephrine	113-127	Calcium-activated potassium channel subunit alpha-1	Ovis aries	77-81
23371827-6	2013	Minute ventilation, oxygen consumption and levels of plasma lactate and norepinephrine were significantly higher (P<0.05) in RAIN than in CON.	Norepinephrine	72-86	Ras interacting protein 1	Homo sapiens	128-132
23718987-3	2013	We hypothesized that norepinephrine acting through specific adrenergic receptors expressed on keratinocytes stimulates the production of IL-6 and leads to nociceptive sensitization in a rat tibial fracture/cast model of CRPS.	Norepinephrine	21-35	interleukin 6	Rattus norvegicus	137-141
23844252-0	2013	Norepinephrine inhibits macrophage migration by decreasing CCR2 expression.	Norepinephrine	0-14	C-C motif chemokine receptor 2	Homo sapiens	59-63
23639786-8	2013	In addition, activation of phospholipase C gamma and the downstream protein kinase C alpha were shown to be already activated in pancreatic cancer cells and cannot be further activated by norepinephrine.	Norepinephrine	188-202	protein kinase C alpha	Homo sapiens	68-90
23874864-7	2013	Lung weight, urinary norepinephrine excretion, and LV end-diastolic pressure were significantly lower and LV dimension was significantly smaller in MI-induced heart failure treated with TLR4-SiRNA than in that treated with hGAPDH-SiRNA for 2 weeks.	Norepinephrine	21-35	toll-like receptor 4	Rattus norvegicus	186-190
24224084-1	2013	Angiotensin II (AngII) facilitates sympathetic neurotransmission by regulating norepinephrine (NE) synthesis, release and uptake.	Norepinephrine	79-93	angiotensinogen	Rattus norvegicus	0-14
24224084-1	2013	Angiotensin II (AngII) facilitates sympathetic neurotransmission by regulating norepinephrine (NE) synthesis, release and uptake.	Norepinephrine	79-93	angiotensinogen	Rattus norvegicus	16-21
23643838-1	2013	Hemodynamic stress via hypotensive challenge has been shown previously to cause a corticotropin-releasing factor (CRF)-mediated increase in tonic locus coeruleus (LC) activity and consequent release of norepinephrine (NE) in noradrenergic terminal fields.	Norepinephrine	202-216	corticotropin releasing hormone	Rattus norvegicus	82-112
23583454-4	2013	3,4-Methylenedioxypyrovalerone and naphyrone had high affinity for radioligand binding sites on recombinant human dopamine (hDAT), serotonin (hSERT) and norepinephrine (hNET) transporters, potently inhibited [3H]neurotransmitter uptake, and, like cocaine, did not induce transporter-mediated release.	Norepinephrine	153-167	solute carrier family 6 member 2	Homo sapiens	169-173
23040084-9	2013	Noradrenaline and serotonin basal levels were altered in the dorsal raphe nucleus from GIRK2 heterozygous and homozygous mice, respectively.	Norepinephrine	0-13	potassium inwardly-rectifying channel, subfamily J, member 6	Mus musculus	87-92
22382522-0	2013	Berberine inhibits norepinephrine-induced apoptosis in neonatal rat cardiomyocytes via inhibiting ROS-TNF-alpha-caspase signaling pathway.	Norepinephrine	19-33	tumor necrosis factor	Rattus norvegicus	102-111
23946762-4	2013	TH promoter haplotype 2 (TGGG) showed pleiotropy, increasing both norepinephrine excretion and blood pressure during stress.	Norepinephrine	66-80	tyrosine hydroxylase	Homo sapiens	0-2
23276884-1	2013	DOPA decarboxylase (DDC) is involved in the synthesis of dopamine, norepinephrine and serotonin.	Norepinephrine	67-81	dopa decarboxylase	Homo sapiens	0-18
23276884-1	2013	DOPA decarboxylase (DDC) is involved in the synthesis of dopamine, norepinephrine and serotonin.	Norepinephrine	67-81	dopa decarboxylase	Homo sapiens	20-23
22706789-3	2013	Specifically, we generated a reporter mouse strain in which a nuclear-localized enhanced green fluorescent protein gene (nEGFP) was inserted into exon 1 of the gene encoding Phenylethanolamine n-methyltransferase (Pnmt), the enzyme responsible for production of adrenaline from noradrenaline.	Norepinephrine	278-291	phenylethanolamine-N-methyltransferase	Mus musculus	174-212
22706789-3	2013	Specifically, we generated a reporter mouse strain in which a nuclear-localized enhanced green fluorescent protein gene (nEGFP) was inserted into exon 1 of the gene encoding Phenylethanolamine n-methyltransferase (Pnmt), the enzyme responsible for production of adrenaline from noradrenaline.	Norepinephrine	278-291	phenylethanolamine-N-methyltransferase	Mus musculus	214-218
23443926-3	2013	In the present study, we evaluated this possibility and found that injecting rats with clenbuterol or norepinephrine induced large increases in PGC-1alpha and mitochondrial proteins in brown adipose tissue but had no effect on PGC-1alpha expression or mitochondrial biogenesis in skeletal muscle.	Norepinephrine	102-116	PPARG coactivator 1 alpha	Rattus norvegicus	144-154
24900709-1	2013	The objective of the described research effort was to identify a novel serotonin and norepinephrine reuptake inhibitor (SNRI) with improved norepinephrine transporter activity and acceptable metabolic stability and exhibiting minimal drug-drug interaction.	Norepinephrine	85-99	solute carrier family 6 member 2	Homo sapiens	140-166
23460120-0	2013	Noradrenaline induces binding of Clathrin light chain A to alpha1-adrenoceptors in the human prostate.	Norepinephrine	0-13	clathrin light chain A	Homo sapiens	33-55
23460120-11	2013	Stimulation of prostate tissues with noradrenaline (30 microM) in vitro induced binding of clathrin LCA to alpha1A-adrenoceptors.	Norepinephrine	37-50	clathrin light chain A	Homo sapiens	100-103
23708099-3	2013	In mammals, nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) blocks noradrenaline-induced melatonin synthesis in pinealocytes, which induces melatonin synthesis in macrophages.	Norepinephrine	119-132	nuclear factor kappa B subunit 1	Homo sapiens	101-110
23630294-5	2013	Behavioral studies of mice lacking Rgs4, including specific knockdowns in NAc, demonstrate that Rgs4 in this brain region acts as a positive modulator of the antidepressant-like and antiallodynic-like actions of several monoamine-directed antidepressant drugs, including tricyclic antidepressants, selective serotonin reuptake inhibitors, and norepinephrine reuptake inhibitors.	Norepinephrine	343-357	regulator of G-protein signaling 4	Mus musculus	96-100
23543756-9	2013	First, sympathetic nerve-derived norepinephrine directly restrains MCP-1 production by peritoneal macrophages during infection.	Norepinephrine	33-47	mast cell protease 1	Mus musculus	67-72
23276607-6	2013	PFC tissue from ACTH pre-treated animals contained significantly higher serotonin, noradrenaline and adrenaline concentrations relative to saline pre-treated controls.	Norepinephrine	83-96	proopiomelanocortin	Homo sapiens	16-20
23517603-12	2013	Corticosterone and noradrenaline, at pathophysiological levels, increased expression and secretion of IL-6 in B16-F10 cells in vitro.	Norepinephrine	19-32	interleukin 6	Mus musculus	102-106
23517603-13	2013	Corticosterone- and noradrenaline-induced transcriptional up-regulation of IL-6 gene involves changes in the DNA binding activity of nuclear factor-kappaB, cAMP response element-binding protein, activator protein-1, and nuclear factor for IL-6.	Norepinephrine	20-33	interleukin 6	Mus musculus	75-79
23517603-13	2013	Corticosterone- and noradrenaline-induced transcriptional up-regulation of IL-6 gene involves changes in the DNA binding activity of nuclear factor-kappaB, cAMP response element-binding protein, activator protein-1, and nuclear factor for IL-6.	Norepinephrine	20-33	interleukin 6	Mus musculus	239-243
23283360-10	2013	Correlates of insulin resistance in SS were mean arterial pressure, epinephrine, and norepinephrine, all remaining as significant predictors in multivariate modeling.	Norepinephrine	85-99	insulin	Homo sapiens	14-21
23573890-4	2013	The data provided in the present study, demonstrate the novel ultrastructural immunolocalization of both CgA and VMAT2 in protein bodies, supporting their involvement in somatodendritic storage and release of noradrenaline in human LC.	Norepinephrine	209-222	chromogranin A	Homo sapiens	105-108
22971929-5	2013	ANG II infusion resulted in higher levels of glutamate, norepinephrine (NE), AT1-R and pro-inflammatory cytokines (PIC), and lower level of gamma-aminobutyric acid (GABA) in the PVN.	Norepinephrine	56-70	angiotensinogen	Rattus norvegicus	0-6
22290536-8	2013	In addition, enhanced IL-6 promoter activity can be similarly induced by ET-1 and catecholamines (epinephrine and norepinephrine).	Norepinephrine	114-128	interleukin 6	Mus musculus	22-26
23224983-2	2013	Among its multiple cellular tasks, ATP7A transfers copper to dopamine beta hydroxylase (DBH) within the lumen of the Golgi network or secretory granules, catalyzing the conversion of dopamine to norepinephrine.	Norepinephrine	195-209	ATPase, Cu++ transporting, alpha polypeptide	Mus musculus	35-40
23224983-2	2013	Among its multiple cellular tasks, ATP7A transfers copper to dopamine beta hydroxylase (DBH) within the lumen of the Golgi network or secretory granules, catalyzing the conversion of dopamine to norepinephrine.	Norepinephrine	195-209	dopamine beta hydroxylase	Mus musculus	61-86
23224983-2	2013	Among its multiple cellular tasks, ATP7A transfers copper to dopamine beta hydroxylase (DBH) within the lumen of the Golgi network or secretory granules, catalyzing the conversion of dopamine to norepinephrine.	Norepinephrine	195-209	dopamine beta hydroxylase	Mus musculus	88-91
23288844-3	2013	The closely related transporters for noradrenaline and dopamine depend on SEC24D.	Norepinephrine	37-50	SEC24 homolog D, COPII coat complex component	Homo sapiens	74-80
23421681-4	2013	The 6-position of serotonin and the para-hydroxyl groups of dopamine and norepinephrine were found to face Ala173 in hSERT, Gly153 in hDAT, and Gly149 in hNET.	Norepinephrine	73-87	solute carrier family 6 member 4	Homo sapiens	117-122
23421681-4	2013	The 6-position of serotonin and the para-hydroxyl groups of dopamine and norepinephrine were found to face Ala173 in hSERT, Gly153 in hDAT, and Gly149 in hNET.	Norepinephrine	73-87	solute carrier family 6 member 2	Homo sapiens	154-158
23421681-7	2013	Uptake experiments support that the 5-hydroxyl group of serotonin and the meta-hydroxyl group norepinephrine and dopamine are placed in the hydrophilic pocket around Ala173, Ser438, and Thr439 in hSERT corresponding to Gly149, Ser419, Ser420 in hNET and Gly153 Ser422 and Ala423 in hDAT.	Norepinephrine	94-108	solute carrier family 6 member 4	Homo sapiens	196-201
23421681-7	2013	Uptake experiments support that the 5-hydroxyl group of serotonin and the meta-hydroxyl group norepinephrine and dopamine are placed in the hydrophilic pocket around Ala173, Ser438, and Thr439 in hSERT corresponding to Gly149, Ser419, Ser420 in hNET and Gly153 Ser422 and Ala423 in hDAT.	Norepinephrine	94-108	solute carrier family 6 member 2	Homo sapiens	245-249
23114721-9	2013	The blood pressure response to ganglionic blockade, cardiac sympathetic nerve activity, and cardiac sympathetic afferent reflex (CSAR) were enhanced, and the plasma norepinephrine level was increased in SHR, which were prevented by SOD1 gene transfer in the PVN.	Norepinephrine	165-179	superoxide dismutase 1	Rattus norvegicus	232-236
23264683-4	2013	Norepinephrine and CGRP act through the alpha(2)-adrenergic receptor and CGRP receptor, respectively, because blocking these receptors prevented fibrosis, the inflammatory response, and tubular cell death.	Norepinephrine	0-14	calcitonin related polypeptide alpha	Homo sapiens	73-77
23107618-8	2013	Our results are consistent with a recent theoretical account that links changes in ERP amplitude in the P300 time range with phasic activity of the locus coeruleus-norepinephrine system and decisions to engage in exploratory behavior.	Norepinephrine	164-178	ETS transcription factor ELK3	Homo sapiens	83-86
23065569-1	2013	The aim of this study was to investigate the expression of vascular endothelial growth factor type C (VEGF-C) in oral squamous cell carcinoma (OSCC) cell lines through norepinephrine-induced activation of beta-adrenergic receptors.	Norepinephrine	168-182	vascular endothelial growth factor C	Homo sapiens	59-100
23065569-1	2013	The aim of this study was to investigate the expression of vascular endothelial growth factor type C (VEGF-C) in oral squamous cell carcinoma (OSCC) cell lines through norepinephrine-induced activation of beta-adrenergic receptors.	Norepinephrine	168-182	vascular endothelial growth factor C	Homo sapiens	102-108
23065569-4	2013	VEGF-C protein levels produced by oral malignant cell lines after stimulation with different norepinephrine concentrations or blocking with propranolol was statistically similar (p > 0.05) to those of the control group (nonstimulated OSCC cell lines).	Norepinephrine	93-107	vascular endothelial growth factor C	Homo sapiens	0-6
23290933-10	2013	These results suggest that systemic epinephrine, perhaps by evoking central norepinephrine release, modulated the increase in the forebrain GABA(A) receptor recruitment induced by both insulin and stress in different ways depending on the subpopulation fearfulness.	Norepinephrine	76-90	insulin	Homo sapiens	185-192
24054138-1	2013	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline, and adrenaline.	Norepinephrine	106-119	tyrosine hydroxylase	Homo sapiens	0-20
24054138-1	2013	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline, and adrenaline.	Norepinephrine	106-119	tyrosine hydroxylase	Homo sapiens	22-24
24054142-1	2013	Work from our laboratory has established that angiotensin II (Ang II) produces a greater enhancement of the nerve stimulation (NS)-induced release (overflow) of both norepinephrine (NE) and neuropeptide Y (NPY) and a greater increase in perfusion pressure of the mesenteric arterial bed obtained from the spontaneously hypertensive rat (SHR) compared to age-matched Wistar-Kyoto (WKY) or Sprague-Dawley rats.	Norepinephrine	166-180	angiotensinogen	Rattus norvegicus	46-60
24054142-1	2013	Work from our laboratory has established that angiotensin II (Ang II) produces a greater enhancement of the nerve stimulation (NS)-induced release (overflow) of both norepinephrine (NE) and neuropeptide Y (NPY) and a greater increase in perfusion pressure of the mesenteric arterial bed obtained from the spontaneously hypertensive rat (SHR) compared to age-matched Wistar-Kyoto (WKY) or Sprague-Dawley rats.	Norepinephrine	166-180	angiotensinogen	Rattus norvegicus	62-68
24642842-4	2013	The mRNA and protein expression of ADAMTS-1, -4, and -7 and MMP-9 were determined using real-time PCR, Western blot, and immunohistochemistry 3 days after Ang II or norepinephrine administration.	Norepinephrine	165-179	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1	Mus musculus	35-55
24454513-7	2013	Moreover, levels of hypothalamic dopamine (DA) and norepinephrine (NE) rallied significantly after RRF treatment.	Norepinephrine	51-65	mitochondrial ribosome recycling factor	Rattus norvegicus	99-102
24251033-3	2013	Central administration of salusin- beta increases blood pressure via release of norepinephrine and arginine-vasopressin.	Norepinephrine	80-94	torsin family 2 member A	Homo sapiens	26-39
23010362-1	2013	The interaction of the selective norepinephrine reuptake inhibitor (-)-reboxetine with the human alpha4beta2 nicotinic acetylcholine receptor (nAChR) in different conformational states was studied by several functional and structural approaches.	Norepinephrine	33-47	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	143-148
23086945-1	2012	The serotonin transporter (SERT) and the norepinephrine transporter (NET) are sodium-dependent neurotransmitter transporters responsible for reuptake of released serotonin and norepinephrine, respectively, into nerve terminals in the brain.	Norepinephrine	41-55	solute carrier family 6 member 4	Homo sapiens	4-25
23555928-10	2013	Finally, adult Pmch-deficient rats had lower norepinephrine turnover (an index of sympathetic adipose drive) in WAT and iBAT than wild-type rats.	Norepinephrine	45-59	pro-melanin-concentrating hormone	Rattus norvegicus	15-19
23086945-1	2012	The serotonin transporter (SERT) and the norepinephrine transporter (NET) are sodium-dependent neurotransmitter transporters responsible for reuptake of released serotonin and norepinephrine, respectively, into nerve terminals in the brain.	Norepinephrine	41-55	solute carrier family 6 member 4	Homo sapiens	27-31
23086945-1	2012	The serotonin transporter (SERT) and the norepinephrine transporter (NET) are sodium-dependent neurotransmitter transporters responsible for reuptake of released serotonin and norepinephrine, respectively, into nerve terminals in the brain.	Norepinephrine	41-55	solute carrier family 6 member 2	Homo sapiens	69-72
22763617-4	2012	Taar1 transgenic mice did not show overt behavioral abnormalities under baseline conditions, despite augmented extracellular levels of dopamine and noradrenaline in the accumbens nucleus (Acb) and of serotonin in the medial prefrontal cortex.	Norepinephrine	148-161	trace amine-associated receptor 1	Mus musculus	0-5
23023867-1	2012	Approximately 80-90% of the norepinephrine released in the brain or in peripheral tissues is taken up again through the neuronal norepinephrine transporter (NET).	Norepinephrine	28-42	solute carrier family 6 member 2	Homo sapiens	129-155
23023867-1	2012	Approximately 80-90% of the norepinephrine released in the brain or in peripheral tissues is taken up again through the neuronal norepinephrine transporter (NET).	Norepinephrine	28-42	solute carrier family 6 member 2	Homo sapiens	157-160
22833121-7	2012	In addition, treatment with the LXR agonist improved the vasomotor function of atherosclerotic arteries, as assessed by KCl/norepinephrine-induced vasoconstrictive and acetylcholine-induced vasorelaxation functional assays.	Norepinephrine	124-138	nuclear receptor subfamily 1, group H, member 3	Mus musculus	32-35
22923736-1	2012	We reported previously that natriuretic peptides, including brain natriuretic peptide (BNP), promote norepinephrine release from cardiac sympathetic nerves and dopamine release from differentiated pheochromocytoma PC12 cells.	Norepinephrine	101-115	natriuretic peptide B	Rattus norvegicus	60-85
22923736-1	2012	We reported previously that natriuretic peptides, including brain natriuretic peptide (BNP), promote norepinephrine release from cardiac sympathetic nerves and dopamine release from differentiated pheochromocytoma PC12 cells.	Norepinephrine	101-115	natriuretic peptide B	Rattus norvegicus	87-90
22923736-7	2012	Indeed, selective H(3) and H(4) receptor agonists each synergized with a PKG inhibitor and a PDE3 activator in attenuating BNP-induced norepinephrine release from cardiac sympathetic nerve endings.	Norepinephrine	135-149	natriuretic peptide B	Rattus norvegicus	123-126
24900562-1	2013	Herein, we describe the discovery of inhibitors of norepinephrine (NET) and dopamine (DAT) transporters with reduced activity relative to serotonin transporters (SERT).	Norepinephrine	51-65	solute carrier family 6 member 4	Rattus norvegicus	138-160
22964465-0	2012	Involvement of presynaptic voltage-dependent Kv3 channel in endothelin-1-induced inhibition of noradrenaline release from rat gastric sympathetic nerves.	Norepinephrine	95-108	endothelin 1	Rattus norvegicus	60-72
23000030-0	2012	Interleukin-1 beta simultaneously affects the stress and reproductive axes by modulating norepinephrine levels in different brain areas.	Norepinephrine	89-103	interleukin 1 beta	Rattus norvegicus	0-18
22874414-0	2012	A second extracellular site is required for norepinephrine transport by the human norepinephrine transporter.	Norepinephrine	44-58	solute carrier family 6 member 2	Homo sapiens	82-108
22911456-3	2012	To perform this study, we used a mouse model with targeted disruption of the Dopamine beta-hydroxylase (Dbh) gene, whose product is responsible for enzymatic conversion of dopamine into norepinephrine.	Norepinephrine	186-200	dopamine beta hydroxylase	Mus musculus	77-102
22911456-3	2012	To perform this study, we used a mouse model with targeted disruption of the Dopamine beta-hydroxylase (Dbh) gene, whose product is responsible for enzymatic conversion of dopamine into norepinephrine.	Norepinephrine	186-200	dopamine beta hydroxylase	Mus musculus	104-107
22805235-1	2012	We have previously reported that noradrenaline (NA) microinjected into the lateral septal area (LSA) caused pressor and bradicardic responses that were mediated by vasopressin release into the circulation through the paraventricular nucleus of hypothalamus (PVN).	Norepinephrine	33-46	arginine vasopressin	Rattus norvegicus	164-175
22664956-7	2012	The M/I value independently predicted whole-body norepinephrine spillover (r = -0.47; P = 0.008), whereas fasting insulin level related to neuronal norepinephrine reuptake (r = -0.35, P = 0.047).	Norepinephrine	148-162	insulin	Homo sapiens	114-121
22901823-5	2012	Using the organ bath technique, the effects of the phosphodiesterase type (PDE)4 inhibitors Ro 20-1724, rolipram, and RP 73401 on the tension induced by norepinephrine of isolated prostatic tissue were investigated and compared with the PDE5 inhibitor sildenafil and BAY 13-1197, a nitric oxide-independent activator of the soluble guanylyl cyclase.	Norepinephrine	153-167	phosphodiesterase 4A	Homo sapiens	51-80
22761303-6	2012	ALDH2 activation substantially reduced acetaldehyde- and hypoxia-induced norepinephrine release, an action prevented by inhibition of ALDH2 or protein kinase Cepsilon (PKCepsilon).	Norepinephrine	73-87	protein kinase C, epsilon	Rattus norvegicus	143-166
22761303-6	2012	ALDH2 activation substantially reduced acetaldehyde- and hypoxia-induced norepinephrine release, an action prevented by inhibition of ALDH2 or protein kinase Cepsilon (PKCepsilon).	Norepinephrine	73-87	protein kinase C, epsilon	Rattus norvegicus	168-178
22761303-12	2012	This pathway comprises the sequential activation of PKCepsilon and ALDH2, culminating in aldehyde detoxification and inhibition of hypoxic norepinephrine release.	Norepinephrine	139-153	protein kinase C, epsilon	Rattus norvegicus	52-62
22761303-13	2012	Thus, pharmacological activation of PKCepsilon and ALDH2 in cardiac sympathetic nerves may have significant protective effects by alleviating norepinephrine-induced life-threatening arrhythmias that characterize myocardial ischemia/reperfusion.	Norepinephrine	142-156	protein kinase C, epsilon	Rattus norvegicus	36-46
22761303-0	2012	Aldehyde dehydrogenase type 2 activation by adenosine and histamine inhibits ischemic norepinephrine release in cardiac sympathetic neurons: mediation by protein kinase Cepsilon.	Norepinephrine	86-100	protein kinase C, epsilon	Rattus norvegicus	154-177
22617505-10	2012	CRP positively correlated with the doses of the epinephrine and norepinephrine and the monocyte counts, and negatively correlated with the lymphocyte count.	Norepinephrine	64-78	C-reactive protein	Homo sapiens	0-3
22483786-7	2012	Our studies have shown that I(1)-receptor is expressed in cardiac fibroblasts and myocytes and that in vitro I(1)-receptor activation inhibits norepinephrine-induced cardiomyocyte apoptosis and fibroblast proliferation, through differential effects on mitogen-activated protein kinases and Akt.	Norepinephrine	143-157	AKT serine/threonine kinase 1	Homo sapiens	290-293
22855557-6	2012	beta1-response to norepinephrine was assessed using the chronotropic responsiveness index: DeltaHR/Deltalog norepinephrine.	Norepinephrine	18-32	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	0-5
22855557-6	2012	beta1-response to norepinephrine was assessed using the chronotropic responsiveness index: DeltaHR/Deltalog norepinephrine.	Norepinephrine	108-122	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	0-5
22858378-0	2012	Transglutaminase-mediated transamidation of serotonin, dopamine and noradrenaline to fibronectin: evidence for a general mechanism of monoaminylation.	Norepinephrine	68-81	fibronectin 1	Homo sapiens	85-96
22858378-4	2012	Here we show that the catecholamines dopamine (DA) and noradrenaline (NA) inhibit serotonylation of fibronectin and that DA and NA themselves can be selectively transamidated into fibronectin by TGase.	Norepinephrine	55-68	fibronectin 1	Homo sapiens	100-111
22858378-4	2012	Here we show that the catecholamines dopamine (DA) and noradrenaline (NA) inhibit serotonylation of fibronectin and that DA and NA themselves can be selectively transamidated into fibronectin by TGase.	Norepinephrine	55-68	fibronectin 1	Homo sapiens	180-191
22652222-2	2012	We previously reported that microinjection of noradrenaline (NA) into the MeA of unanesthetized rats caused pressor and bradycardiac responses, which were mediated by acute vasopressin release into the systemic circulation.	Norepinephrine	46-59	arginine vasopressin	Rattus norvegicus	173-184
22518026-5	2012	RESULTS: Equal BPs were maintained in both treatment groups, with a significant reduction in norepinephrine requirements in the patients treated with vasopressin.	Norepinephrine	93-107	arginine vasopressin	Homo sapiens	150-161
22441984-5	2012	Norepinephrine-induced ROS resulted in an increase in PKCepsilon promoter methylation at Egr-1 and Sp-1 binding sites, leading to PKCepsilon gene repression.	Norepinephrine	0-14	early growth response 1	Rattus norvegicus	89-94
21835087-4	2012	This study was conducted to elucidate a possible role of PFC activity of an enzyme involved in the release of docosahexaenoic acid (DHA), i.e. calcium-independent phospholipase A2 (iPLA2), in the effects of the norepinephrine reuptake inhibitor (NRI) antidepressant, maprotiline, in mice.	Norepinephrine	211-225	phospholipase A2, group VI	Mus musculus	143-179
21835087-4	2012	This study was conducted to elucidate a possible role of PFC activity of an enzyme involved in the release of docosahexaenoic acid (DHA), i.e. calcium-independent phospholipase A2 (iPLA2), in the effects of the norepinephrine reuptake inhibitor (NRI) antidepressant, maprotiline, in mice.	Norepinephrine	211-225	phospholipase A2, group VI	Mus musculus	181-186
22609930-0	2012	Titration of synaptotagmin I expression differentially regulates release of norepinephrine and neuropeptide Y.	Norepinephrine	76-90	synaptotagmin 1	Rattus norvegicus	13-28
22609331-0	2012	Norepinephrine differentially modulates the innate inflammatory response provoked by amyloid-beta peptide via action at beta-adrenoceptors and activation of cAMP/PKA pathway in human THP-1 macrophages.	Norepinephrine	0-14	GLI family zinc finger 2	Homo sapiens	183-188
22609930-4	2012	We determined the functional effects of titrated syt I expression on transmitter release from the two vesicle types, and showed that the transmitters, norepinephrine (NE) and neuropeptide Y (NPY), each have a threshold level of syt I expression required for their release that is different for the two transmitter types.	Norepinephrine	151-165	synaptotagmin 1	Rattus norvegicus	228-233
22889256-9	2012	A meta-analysis using a fixed-effect model showed a reduction in norepinephrine requirement among patients receiving terlipressin or vasopressin infusion compared with control (standardized mean difference, -1.58 (95% confidence interval, -1.73 to -1.44); P < 0.0001).	Norepinephrine	65-79	arginine vasopressin	Homo sapiens	133-144
22510725-2	2012	The neuropeptide, corticotropin-releasing factor (CRF), coordinates the physiological and behavioral responses to stress, in part, by activating the locus coeruleus-norepinephrine (LC-NE) projection system.	Norepinephrine	165-179	corticotropin releasing hormone	Rattus norvegicus	18-48
22492651-0	2012	Evolving insights regarding mechanisms for the inhibition of insulin release by norepinephrine and heterotrimeric G proteins.	Norepinephrine	80-94	insulin	Homo sapiens	61-68
22364229-6	2012	JNK activation by noradrenaline (30 microM) and phenylephrine (10 microM), and the effects of JNK inhibitors of c-Jun phosphorylation were assessed by Western blot analyses with phospho-specific antibodies.	Norepinephrine	18-31	mitogen-activated protein kinase 8	Homo sapiens	0-3
22364229-8	2012	KEY RESULTS The JNK inhibitors SP600125 and BI-78D3 reduced phenylephrine- and noradrenaline-induced contractions of human prostate strips.	Norepinephrine	79-92	mitogen-activated protein kinase 8	Homo sapiens	16-19
22364229-10	2012	Stimulation of prostate tissue with noradrenaline or phenylephrine in vitro resulted in activation of JNK.	Norepinephrine	36-49	mitogen-activated protein kinase 8	Homo sapiens	102-105
22492651-1	2012	Norepinephrine has for many years been known to have three major effects on the pancreatic beta-cell which lead to the inhibition of insulin release.	Norepinephrine	0-14	insulin	Homo sapiens	133-140
22233532-9	2012	Mesenteric resistance arteries from anti-TLR4-treated SHR exhibited decreased maximal contractile response to NA (noradrenaline) compared with IgG-treated SHR.	Norepinephrine	114-127	toll-like receptor 4	Rattus norvegicus	41-45
22483310-3	2012	Tyrosine hydroxylase (TH) is an important neuronal enzyme that, in the presence of tetrahydrobiopterin, catalyzes the initial and rate-limiting step in the biosynthesis of the catecholamine neurotransmitters dopamine (DA) and norepinephrine, and is frequently used as a marker of DAergic neuronal loss in animal models of PD.	Norepinephrine	226-240	tyrosine hydroxylase	Homo sapiens	0-20
22483310-3	2012	Tyrosine hydroxylase (TH) is an important neuronal enzyme that, in the presence of tetrahydrobiopterin, catalyzes the initial and rate-limiting step in the biosynthesis of the catecholamine neurotransmitters dopamine (DA) and norepinephrine, and is frequently used as a marker of DAergic neuronal loss in animal models of PD.	Norepinephrine	226-240	tyrosine hydroxylase	Homo sapiens	22-24
21932058-2	2012	The study was tested in a fecal peritonitis-induced septic shock model, we observed that levosimendan combined with arginine vasopressin supplemented with norepinephrine therapy resulted in lower mean pulmonary artery pressure, lactate concentrations, arterial total nitrate/nitrite, and high-mobility group box 1 levels; decreased lung wet/dry ratio, and pulmonary levels of interleukin-6, total histological scores, and improved pulmonary gas exchange when compared with norepinephrine group.	Norepinephrine	473-487	arginine vasopressin	Homo sapiens	125-136
22480387-8	2012	CONCLUSIONS: Our findings further support the hypothesis that the synergistic effect of olanzapine and fluoxetine on prefrontal cortical levels of norepinephrine and dopamine might be an underlying mechanism for the efficacy of olanzapine-fluoxetine combination in the treatment of treatment-resistant depression and, if replicated, may form a basis on which response to olanzapine-fluoxetine combination versus continued fluoxetine can be predicted based on variants in SLC6A2.	Norepinephrine	147-161	solute carrier family 6 member 2	Homo sapiens	471-477
21932058-2	2012	The study was tested in a fecal peritonitis-induced septic shock model, we observed that levosimendan combined with arginine vasopressin supplemented with norepinephrine therapy resulted in lower mean pulmonary artery pressure, lactate concentrations, arterial total nitrate/nitrite, and high-mobility group box 1 levels; decreased lung wet/dry ratio, and pulmonary levels of interleukin-6, total histological scores, and improved pulmonary gas exchange when compared with norepinephrine group.	Norepinephrine	155-169	interleukin 6	Homo sapiens	376-389
22579288-3	2012	BMP8B is induced by nutritional and thermogenic factors in mature BAT, increasing the response to noradrenaline through enhanced p38MAPK/CREB signaling and increased lipase activity.	Norepinephrine	98-111	cAMP responsive element binding protein 1	Mus musculus	137-141
22664332-9	2012	The ratios of noradrenaline and adrenaline to dopamine in the brain were also increased by the treatment, suggesting that dopamine beta-hydroxylase activity was improved by the combination therapy.	Norepinephrine	14-27	dopamine beta hydroxylase	Mus musculus	122-147
22318196-8	2012	In cultured hippocampal neurons, application of serotonin or norepinephrine (10-50 muM) induced increase in synaptic transmission and targeting of BDNF mRNA in dendrites.	Norepinephrine	61-75	latexin	Homo sapiens	83-86
22438289-11	2012	Also, exposure to elevated levels of norepinephrine triggers release of vascular endothelial growth factor, which facilitates tumor growth.	Norepinephrine	37-51	vascular endothelial growth factor A	Homo sapiens	72-106
22660994-6	2012	Plasma levels of chromogranin A, calcitonin, parathormone, basal renin and most prominently VIP were increased in line with a increased 24 hour urinary secretion of noradrenaline, dopamine, normetanephrine and vanillymandelic acid.	Norepinephrine	165-178	vasoactive intestinal peptide	Homo sapiens	92-95
22351634-10	2012	Without CO(2)/HCO(3)(-), effects of NO synthase and rho kinase inhibition on noradrenaline-induced contractions were smaller in arteries from NHE1 knockout than wild-type mice whereas the EC Ca(2+) response to acetylcholine, VSMC Ca(2+) response to noradrenaline and vasorelaxation to S-nitroso-N-acetylpenicillamine were unaffected.	Norepinephrine	77-90	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	52-62
22322975-6	2012	Functionally, ANG II-induced downregulation of RhoA-GEFs is associated with decreased Rho kinase activation in response to endothelin-1, norepinephrine, and U-46619.	Norepinephrine	137-151	angiotensinogen	Rattus norvegicus	14-20
22566195-1	2012	Tumor-specific uptake of the radiolabeled nor-epinephrine analogue meta-iodobenzylguanidine via norepinephrine transporter or radiolabeled somatostatin analogues octreotide/octreotate via somatostatin receptors offers possibilities to diagnose and treat metastatic pheochromocytoma/paraganglioma.	Norepinephrine	42-57	solute carrier family 6 member 2	Homo sapiens	96-122
21702050-10	2012	(f) p38-MAPK and Tpl2 were crucial intermediates for both CRF(1) and CRF(2)-induced norepinephrine production, while AKT1 affected only CRF(2)-induced norepinephrine production.	Norepinephrine	151-165	AKT serine/threonine kinase 1	Rattus norvegicus	117-121
22020907-0	2012	Norepinephrine stimulates pancreatic cancer cell proliferation, migration and invasion via beta-adrenergic receptor-dependent activation of P38/MAPK pathway.	Norepinephrine	0-14	mitogen-activated protein kinase 14	Homo sapiens	140-143
22351634-10	2012	Without CO(2)/HCO(3)(-), effects of NO synthase and rho kinase inhibition on noradrenaline-induced contractions were smaller in arteries from NHE1 knockout than wild-type mice whereas the EC Ca(2+) response to acetylcholine, VSMC Ca(2+) response to noradrenaline and vasorelaxation to S-nitroso-N-acetylpenicillamine were unaffected.	Norepinephrine	77-90	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	142-146
22398028-0	2012	Norepinephrine suppresses IFN-gamma and TNF-alpha production by murine intestinal intraepithelial lymphocytes via the beta1 adrenoceptor.	Norepinephrine	0-14	interferon gamma	Mus musculus	26-35
21590324-1	2012	The aim of this study was to investigate whether norepinephrine (NE) could regulate macrophage production of tumor necrosis factor alpha (TNF-alpha) by influencing the phosphorylation of mitogen-activated protein kinases (MAPKs).	Norepinephrine	49-63	tumor necrosis factor	Mus musculus	109-136
21590324-1	2012	The aim of this study was to investigate whether norepinephrine (NE) could regulate macrophage production of tumor necrosis factor alpha (TNF-alpha) by influencing the phosphorylation of mitogen-activated protein kinases (MAPKs).	Norepinephrine	49-63	tumor necrosis factor	Mus musculus	138-147
22398028-0	2012	Norepinephrine suppresses IFN-gamma and TNF-alpha production by murine intestinal intraepithelial lymphocytes via the beta1 adrenoceptor.	Norepinephrine	0-14	tumor necrosis factor	Mus musculus	40-49
22317959-1	2012	Activity of locus coeruleus (LC) neurons and release of the peptide galanin (GAL), which is colocalized with norepinephrine (NE) in LC neurons, has been implicated in depression and, conversely, in antidepressant action.	Norepinephrine	109-123	galanin and GMAP prepropeptide	Rattus norvegicus	68-75
22414636-6	2012	To enhance its therapeutic potential, we have engineered HSV1716 to convey the noradrenaline transporter (NAT) gene (HSV1716/NAT), whose expression endows infected cells with the capacity to accumulate the noradrenaline analog metaiodobenzylguanidine (MIBG).	Norepinephrine	79-92	solute carrier family 6 member 2	Homo sapiens	106-109
22414636-6	2012	To enhance its therapeutic potential, we have engineered HSV1716 to convey the noradrenaline transporter (NAT) gene (HSV1716/NAT), whose expression endows infected cells with the capacity to accumulate the noradrenaline analog metaiodobenzylguanidine (MIBG).	Norepinephrine	79-92	solute carrier family 6 member 2	Homo sapiens	125-128
22317959-1	2012	Activity of locus coeruleus (LC) neurons and release of the peptide galanin (GAL), which is colocalized with norepinephrine (NE) in LC neurons, has been implicated in depression and, conversely, in antidepressant action.	Norepinephrine	109-123	galanin and GMAP prepropeptide	Rattus norvegicus	77-80
22311903-2	2012	Norepinephrine transporter blockade with atomoxetine raises blood pressure in autonomic failure by increasing synaptic norepinephrine concentrations in postganglionic sympathetic neurons.	Norepinephrine	119-133	solute carrier family 6 member 2	Homo sapiens	0-26
22405824-0	2012	Desipramine selectively potentiates norepinephrine-elicited ERK1/2 activation through the alpha2A adrenergic receptor.	Norepinephrine	36-50	mitogen-activated protein kinase 3	Homo sapiens	60-66
22280833-8	2012	Akt activation by noradrenaline (30 muM) and phenylephrine (10 muM) was assessed by Western blot analyses with a phospho-specific antibody.	Norepinephrine	18-31	AKT serine/threonine kinase 1	Homo sapiens	0-3
22280833-13	2012	Stimulation of prostate tissues with noradrenaline (30 muM, n=8 patients) or phenylephrine (10 muM, n=7 patients) caused significant Akt phosphorylation at serine-473, indicating activation of Akt.	Norepinephrine	37-50	AKT serine/threonine kinase 1	Homo sapiens	133-136
22280833-13	2012	Stimulation of prostate tissues with noradrenaline (30 muM, n=8 patients) or phenylephrine (10 muM, n=7 patients) caused significant Akt phosphorylation at serine-473, indicating activation of Akt.	Norepinephrine	37-50	AKT serine/threonine kinase 1	Homo sapiens	193-196
22311903-11	2012	In conclusion, the combination of yohimbine and atomoxetine had a synergistic effect on blood pressure and orthostatic tolerance in peripheral autonomic failure, which may be explained by an increased release of norepinephrine in peripheral sympathetic neurons by alpha-2 antagonism combined with a reduced norepinephrine clearance by norepinephrine transporter blockade.	Norepinephrine	212-226	solute carrier family 6 member 2	Homo sapiens	335-361
21953335-6	2012	This anti-inflammatory action of B cells from SNS-intact mice correlated with increased IL-10 produced by B cells, which was mediated by norepinephrine (NE), in a beta(2)AR, PKA-dependent manner.	Norepinephrine	137-151	interleukin 10	Mus musculus	88-93
22210331-0	2012	Predator stress engages corticotropin-releasing factor and opioid systems to alter the operating mode of locus coeruleus norepinephrine neurons.	Norepinephrine	121-135	corticotropin releasing hormone	Rattus norvegicus	24-54
22253419-7	2012	The induction of RBP4 gene expression by norepinephrine required intact PPAR-dependent pathways, as evidenced by impaired response of the RBP4 gene expression to norepinephrine in PPARalpha-null brown adipocytes or in the presence of inhibitors of PPARgamma and PPARalpha.	Norepinephrine	41-55	peroxisome proliferator activated receptor alpha	Mus musculus	72-76
22253419-7	2012	The induction of RBP4 gene expression by norepinephrine required intact PPAR-dependent pathways, as evidenced by impaired response of the RBP4 gene expression to norepinephrine in PPARalpha-null brown adipocytes or in the presence of inhibitors of PPARgamma and PPARalpha.	Norepinephrine	41-55	peroxisome proliferator activated receptor alpha	Mus musculus	180-189
22253419-7	2012	The induction of RBP4 gene expression by norepinephrine required intact PPAR-dependent pathways, as evidenced by impaired response of the RBP4 gene expression to norepinephrine in PPARalpha-null brown adipocytes or in the presence of inhibitors of PPARgamma and PPARalpha.	Norepinephrine	41-55	peroxisome proliferator activated receptor alpha	Mus musculus	262-271
22253419-11	2012	The induction of the RBP4 gene expression by norepinephrine in brown adipocytes is protein synthesis dependent and requires PPARgamma-coactivator-1-alpha, which acts as a norepinephine-induced coactivator of PPAR on the RBP4 gene.	Norepinephrine	45-59	peroxisome proliferator activated receptor alpha	Mus musculus	124-128
22155208-7	2012	Similar to amphetamine, amantadine was inactive at alpha(2A)-adrenergic receptors and induced reverse noradrenaline transport by NAT albeit with smaller effect size.	Norepinephrine	102-115	solute carrier family 6 member 2	Homo sapiens	129-132
22155207-7	2012	In addition, fluoxetine at 0.03 muM and 3 muM significantly enhanced and blocked, respectively, nicotine-induced norepinephrine (NE) release from cerebral perivascular sympathetic nerves.	Norepinephrine	113-127	latexin	Homo sapiens	42-45
22210331-1	2012	The norepinephrine nucleus, locus coeruleus (LC), has been implicated in cognitive aspects of the stress response, in part through its regulation by the stress-related neuropeptide, corticotropin-releasing factor (CRF).	Norepinephrine	4-18	corticotropin releasing hormone	Rattus norvegicus	182-212
22241475-5	2012	The second group comprised adrenaline and noradrenaline which displayed higher intrinsic activity for the ERK phosphorylation than for the cAMP response.	Norepinephrine	42-55	mitogen-activated protein kinase 1	Homo sapiens	106-109
22197205-11	2012	Stimulation of prostate tissue with noradrenaline (30 muM, n = 6 patients) or the alpha1-adrenergic agonist phenylephrine (10 muM, n = 6 patients) resulted in progressive phosphorylation of caldesmon at serine-789.	Norepinephrine	36-49	caldesmon 1	Homo sapiens	190-199
22197205-12	2012	Noradrenaline-induced caldesmon phosphorylation was 1.5 +- 0.2-fold after 5 minutes (P<.04 vs basal phosphorylation), and 1.6 +- 0.2-fold after 10 minutes (P<.04).	Norepinephrine	0-13	caldesmon 1	Homo sapiens	22-31
22166852-7	2012	Multiple-regression analyses showed that baseline IL-2, plasma noradrenaline, and state anxiety predicted nearly 60% of the variance in the conditioned IL-2 response.	Norepinephrine	63-76	interleukin 2	Homo sapiens	152-156
22170706-8	2012	Subjects with an exercise-induced rise in beta-endorphin levels to above 25 pg/ml (n = 7) exhibited markedly reduced levels of plasma epinephrine and norepinephrine compared with control (2495 +- 306 vs. 4810 +- 617 pmol/liter and 1.9 +- 0.3 vs. 2.9 +- 0.4 nmol/liter, respectively, P < 0.01 for both).	Norepinephrine	150-164	proopiomelanocortin	Homo sapiens	42-56
21347606-9	2012	Dopamine doses were positively associated with IL-6, and norepinephrine was inversely associated with IL-8 and TNF-alpha levels.	Norepinephrine	57-71	C-X-C motif chemokine ligand 8	Homo sapiens	102-106
21347606-9	2012	Dopamine doses were positively associated with IL-6, and norepinephrine was inversely associated with IL-8 and TNF-alpha levels.	Norepinephrine	57-71	tumor necrosis factor	Homo sapiens	111-120
22036618-3	2012	Since norepinephrine (NE) is involved in these effects, we hypothesized that IL-1beta acts on brainstem noradrenergic nuclei to affect gene transcription of NE synthesizing enzymes, cytokines and associated transcription factors.	Norepinephrine	6-20	interleukin 1 beta	Rattus norvegicus	77-85
22094068-5	2012	The group treated with amphetamine showed a potentiation of the vas deferens contractions evoked by noradrenaline and barium (about 20%), as well as time-response contractions of calcium (about 20%).	Norepinephrine	100-113	arginine vasopressin	Rattus norvegicus	64-67
22094068-7	2012	The group treated with ethanol showed a decrease in vas deferens contractility to noradrenaline, phenylephrine, and barium, by less than 20%.	Norepinephrine	82-95	arginine vasopressin	Rattus norvegicus	52-55
22916250-0	2012	Beta-adrenergic receptor 1 selective antagonism inhibits norepinephrine-mediated TNF-alpha downregulation in experimental liver cirrhosis.	Norepinephrine	57-71	tumor necrosis factor	Mus musculus	81-90
22127480-9	2012	Metaregression analysis showed negative correlation between vasopressin dose and norepinephrine dose (P = 0.03).	Norepinephrine	81-95	arginine vasopressin	Homo sapiens	60-71
22127480-11	2012	Physicians may value the sparing effects of vasopressin/terlipressin on norepinephrine requirement given its apparent safe profile.	Norepinephrine	72-86	arginine vasopressin	Homo sapiens	44-55
22536490-8	2012	MLP males exhibited greater membrane expression of beta(2)-AR following reperfusion and urinary excretion of noradrenaline and dopamine was lower in MLP and CON female rats versus CON males.	Norepinephrine	109-122	cysteine and glycine rich protein 3	Rattus norvegicus	149-152
22536490-9	2012	In conclusion, the improved cardiac recovery in MLP male offspring following IR was attributed to greater membrane expression of beta(2)-AR and reduced noradrenaline and dopamine levels.	Norepinephrine	152-165	cysteine and glycine rich protein 3	Rattus norvegicus	48-51
20934716-6	2012	The vasorelaxation potency of VEGF(165) (pD(2) = 12.02 +- 0.25; n = 7) was higher (P < 0.05) than that of acetylcholine (pD(2) = 6.76 +- 0.06; n = 5) in human skin flaps preconstricted with 8 x 10(-7)M of norepinephrine.	Norepinephrine	208-222	vascular endothelial growth factor A	Homo sapiens	30-34
23209785-2	2012	Disulfiram inhibits dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine (DA) to norepinephrine (NE) in noradrenergic neurons.	Norepinephrine	95-109	dopamine beta hydroxylase	Mus musculus	20-45
23209785-2	2012	Disulfiram inhibits dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine (DA) to norepinephrine (NE) in noradrenergic neurons.	Norepinephrine	95-109	dopamine beta hydroxylase	Mus musculus	47-50
23209788-8	2012	Preincubation with either the COX-1/2 (indomethacin) or COX-2 inhibitor (NS-398) decreased noradrenaline contraction only in 6- and 12-month-old O-DR, while it remained unmodified by COX-1 inhibitor SC-560.	Norepinephrine	91-104	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	30-37
23209788-8	2012	Preincubation with either the COX-1/2 (indomethacin) or COX-2 inhibitor (NS-398) decreased noradrenaline contraction only in 6- and 12-month-old O-DR, while it remained unmodified by COX-1 inhibitor SC-560.	Norepinephrine	91-104	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	30-35
22011436-2	2012	Conversely, angiotensin II, formed locally by mast cell-derived renin, stimulates NHE via angiotensin II type 1 (AT1) receptors, facilitating norepinephrine release and arrhythmias.	Norepinephrine	142-156	angiotensinogen	Rattus norvegicus	12-26
22011436-2	2012	Conversely, angiotensin II, formed locally by mast cell-derived renin, stimulates NHE via angiotensin II type 1 (AT1) receptors, facilitating norepinephrine release and arrhythmias.	Norepinephrine	142-156	angiotensinogen	Rattus norvegicus	90-104
21993205-0	2012	Corticotropin-releasing factor in the norepinephrine nucleus, locus coeruleus, facilitates behavioral flexibility.	Norepinephrine	38-52	corticotropin releasing hormone	Rattus norvegicus	0-30
21993205-1	2012	Corticotropin-releasing factor (CRF), the stress-related neuropeptide, acts as a neurotransmitter in the brain norepinephrine nucleus, locus coeruleus (LC), to activate this system during stress.	Norepinephrine	111-125	corticotropin releasing hormone	Rattus norvegicus	0-30
23155428-9	2012	More importantly, ACE2 over expression significantly reduced the Ang-II-mediated increase in urine norepinephrine levels in SA compared to NT mice.	Norepinephrine	99-113	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	Mus musculus	18-22
23155428-9	2012	More importantly, ACE2 over expression significantly reduced the Ang-II-mediated increase in urine norepinephrine levels in SA compared to NT mice.	Norepinephrine	99-113	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	65-71
21907406-4	2011	The vasopressin level substantially increased after epinephrine, norepinephrine, serotonin, histamine, dopamine or K(+) treatment.	Norepinephrine	65-79	arginine vasopressin	Rattus norvegicus	4-15
22606238-7	2012	Exposure of cardiomyocytes to angiotensin II and norepinephrine led to ROS generation and M-CK carbonylation with loss of its enzymatic activity.	Norepinephrine	49-63	creatine kinase, M-type	Homo sapiens	90-94
21862727-9	2011	AICAR combined with norepinephrine yielded an additive effect on the PGC-1alpha-b expression only.	Norepinephrine	20-34	PPARG coactivator 1 alpha	Homo sapiens	69-79
21234673-7	2011	The beta(2)-AR-selective agonist terbutaline and the endogenous neurotransmitter norepinephrine decreased VEGF production by MB-231, but increased VEGF production by MB-231BR.	Norepinephrine	81-95	vascular endothelial growth factor A	Homo sapiens	106-110
21234673-7	2011	The beta(2)-AR-selective agonist terbutaline and the endogenous neurotransmitter norepinephrine decreased VEGF production by MB-231, but increased VEGF production by MB-231BR.	Norepinephrine	81-95	vascular endothelial growth factor A	Homo sapiens	147-151
22060292-3	2011	The effect of this safe dose in preventing noradrenaline-induced cardiac hypertrophy was assessed by biochemical analysis (estimating total protein content), molecular analysis (using RT-PCR to study the expression of fetal genes like ANF), immunological analysis (by determining the nuclear localization of GATA-4) and electrophoretic mobility shift assay (EMSA; to study DNA binding activity of GATA-4).	Norepinephrine	43-56	GATA binding protein 4	Rattus norvegicus	308-314
22060292-3	2011	The effect of this safe dose in preventing noradrenaline-induced cardiac hypertrophy was assessed by biochemical analysis (estimating total protein content), molecular analysis (using RT-PCR to study the expression of fetal genes like ANF), immunological analysis (by determining the nuclear localization of GATA-4) and electrophoretic mobility shift assay (EMSA; to study DNA binding activity of GATA-4).	Norepinephrine	43-56	GATA binding protein 4	Rattus norvegicus	397-403
22234076-8	2011	Although there was no retching or vomiting, 80% of patients presented with nausea and exhibited a significant increase in plasma levels of VP, adrenaline and noradrenaline after administration of VP analogue.	Norepinephrine	158-171	arginine vasopressin	Homo sapiens	196-198
22101429-3	2011	Acting via the beta(3)-adrenergic receptors, noradrenaline induces lipolysis in white adipocytes, whereas it stimulates the expression of thermogenic genes, such as PPAR-gamma coactivator 1a (Ppargc1a), uncoupling protein 1 (Ucp1) and acyl-CoA synthetase long-chain family member 1 (Acsl1), in brown adipocytes.	Norepinephrine	45-58	PPARG coactivator 1 alpha	Homo sapiens	165-190
22101429-3	2011	Acting via the beta(3)-adrenergic receptors, noradrenaline induces lipolysis in white adipocytes, whereas it stimulates the expression of thermogenic genes, such as PPAR-gamma coactivator 1a (Ppargc1a), uncoupling protein 1 (Ucp1) and acyl-CoA synthetase long-chain family member 1 (Acsl1), in brown adipocytes.	Norepinephrine	45-58	PPARG coactivator 1 alpha	Homo sapiens	192-200
21756942-0	2011	PTH-receptors regulate norepinephrine release in human heart and kidney.	Norepinephrine	23-37	parathyroid hormone	Homo sapiens	0-3
21538777-0	2011	Reduction in insulin sensitivity following administration of the clinically used low-dose pressor, norepinephrine.	Norepinephrine	99-113	insulin	Homo sapiens	13-20
21983350-3	2011	Because serotonin and norepinephrine systems have been shown to be structurally and functionally highly interrelated, we also examined a novel polymorphism in the promoter region of the norepinephrine transporter gene (NET -3081) in anticipation of epistatic effects.	Norepinephrine	22-36	solute carrier family 6 member 2	Homo sapiens	186-212
21756902-0	2011	Resveratrol prevents norepinephrine induced hypertrophy in adult rat cardiomyocytes, by activating NO-AMPK pathway.	Norepinephrine	21-35	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	102-106
21646052-0	2011	Altered norepinephrine content and ventricular function in p75NTR-/- mice after myocardial infarction.	Norepinephrine	8-22	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	59-65
21646052-7	2011	Norepinephrine content was elevated in the base of the p75NTR-/- ventricle compared to wildtype, but levels were identical below the site of occlusion.	Norepinephrine	0-14	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	55-61
21947296-4	2011	Using myography, arteries from NBCn1 knockout mice showed reduced acetylcholine-induced NO-mediated relaxations and lower rho-kinase-dependent norepinephrine-stimulated smooth muscle Ca2+ sensitivity.	Norepinephrine	143-157	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	122-132
21844155-9	2011	Subnormal norepinephrine spillover in low blood pressure phenotype was linked to low tyrosine hydroxylase (43.7% normal, P=0.001), rate-limiting in norepinephrine synthesis, and in normal blood pressure to increased levels of the norepinephrine transporter (135% normal, P=0.019), augmenting transmitter reuptake.	Norepinephrine	10-24	solute carrier family 6 member 2	Homo sapiens	230-256
21885739-1	2011	The norepinephrine transporter (NET) transports norepinephrine from the synapse into presynaptic neurons, where norepinephrine regulates signaling pathways associated with cardiovascular effects and behavioral traits via binding to various receptors (e.g., beta2-adrenergic receptor).	Norepinephrine	4-18	solute carrier family 6 member 2	Homo sapiens	32-35
21885739-1	2011	The norepinephrine transporter (NET) transports norepinephrine from the synapse into presynaptic neurons, where norepinephrine regulates signaling pathways associated with cardiovascular effects and behavioral traits via binding to various receptors (e.g., beta2-adrenergic receptor).	Norepinephrine	48-62	solute carrier family 6 member 2	Homo sapiens	4-30
21885739-1	2011	The norepinephrine transporter (NET) transports norepinephrine from the synapse into presynaptic neurons, where norepinephrine regulates signaling pathways associated with cardiovascular effects and behavioral traits via binding to various receptors (e.g., beta2-adrenergic receptor).	Norepinephrine	48-62	solute carrier family 6 member 2	Homo sapiens	32-35
21538777-5	2011	We tested the hypothesis that norepinephrine, a plausible exogenous, iatrogenic cause of hyperglycaemia, causes resistance to insulin action with the hyperinsulinaemic-euglycaemic clamp method.	Norepinephrine	30-44	insulin	Homo sapiens	126-133
21538777-10	2011	CONCLUSIONS: Infusion of pressor doses of norepinephrine causes resistance to insulin action in humans.	Norepinephrine	42-56	insulin	Homo sapiens	78-85
21508845-8	2011	The ratio of catestatin to norepinephrine was significantly lower in patients with essential hypertension than in normal controls (P<0.01).	Norepinephrine	27-41	chromogranin A	Homo sapiens	13-23
21508845-13	2011	The ratio of catestatin to norepinephrine was lower in patients with left ventricular hypertrophy.	Norepinephrine	27-41	chromogranin A	Homo sapiens	13-23
21691803-9	2011	Because of the inhibition of norepinephrine reuptake, excessive blood epinephrine levels in this CYP2D6R UM patient following excessive tramadol ingestion could explain the observed strong myocardial stunning.	Norepinephrine	29-43	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	97-103
21892977-4	2011	Rationales for use of vasopressin in septic shock are as follows: first, a deficiency of vasopressin in septic shock; second, low-dose vasopressin infusion improves blood pressure, decreases requirements for norepinephrine and improves renal function; and third, a recent randomized, controlled, concealed trial of vasopressin versus norepinephrine (VASST) suggests low-dose vasopressin may decrease mortality of less severe septic shock.	Norepinephrine	208-222	arginine vasopressin	Homo sapiens	22-33
21892977-4	2011	Rationales for use of vasopressin in septic shock are as follows: first, a deficiency of vasopressin in septic shock; second, low-dose vasopressin infusion improves blood pressure, decreases requirements for norepinephrine and improves renal function; and third, a recent randomized, controlled, concealed trial of vasopressin versus norepinephrine (VASST) suggests low-dose vasopressin may decrease mortality of less severe septic shock.	Norepinephrine	334-348	arginine vasopressin	Homo sapiens	22-33
21892977-7	2011	There was potential benefit in the prospectively defined stratum of patients with less severe septic shock (5 to 14 mug/minute norepinephrine at randomization): vasopressin may have lowered mortality compared with norepinephrine (26% versus 36%, respectively, P = 0.04 within stratum).	Norepinephrine	127-141	arginine vasopressin	Homo sapiens	161-172
21892977-15	2011	In conclusion, low-dose vasopressin may be effective in patients who have less severe septic shock already receiving norepinephrine (such as patients with modest norepinephrine infusion (5 to 15 mug/minute) or low serum lactate levels).	Norepinephrine	117-131	arginine vasopressin	Homo sapiens	24-35
21892977-15	2011	In conclusion, low-dose vasopressin may be effective in patients who have less severe septic shock already receiving norepinephrine (such as patients with modest norepinephrine infusion (5 to 15 mug/minute) or low serum lactate levels).	Norepinephrine	162-176	arginine vasopressin	Homo sapiens	24-35
21575687-1	2011	The supraoptic nuclei (SON), the hypothalamic release site of vasopressin and oxytocin, receive a non-glutamatergic, excitatory input from the caudal medulla that uses noradrenaline and ATP as neurotransmitters.	Norepinephrine	168-181	arginine vasopressin	Rattus norvegicus	62-73
21936631-0	2011	Norepinephrine inhibits intercellular coupling in rat cardiomyocytes by ubiquitination of connexin43 gap junctions.	Norepinephrine	0-14	gap junction protein, alpha 1	Rattus norvegicus	90-100
21936631-2	2011	Here we show that uncoupling in rat cardiomyocytes after stimulation of alpha-adrenergic Galphaq-coupled receptors with norepinephrine is prevented by proteasomal and lysosomal inhibitors, suggesting that internalization and possibly degradation of connexin43 (Cx43) is involved.	Norepinephrine	120-134	gap junction protein, alpha 1	Rattus norvegicus	249-259
21936631-2	2011	Here we show that uncoupling in rat cardiomyocytes after stimulation of alpha-adrenergic Galphaq-coupled receptors with norepinephrine is prevented by proteasomal and lysosomal inhibitors, suggesting that internalization and possibly degradation of connexin43 (Cx43) is involved.	Norepinephrine	120-134	gap junction protein, alpha 1	Rattus norvegicus	261-265
21936631-6	2011	CONCLUSIONS: Norepinephrine increases ubiquitination of Cx43 in cardiomyocytes, possibly via Nedd4.	Norepinephrine	13-27	gap junction protein, alpha 1	Rattus norvegicus	56-60
21668450-7	2011	Deprivation of glucose or stimulation with adenosine or noradrenaline leads to an increased phosphorylation of PP1-R3F bound GS at Ser640 and Ser644 curtailing glycogen synthesis and facilitating glycogen degradation to provide glucose in astrocytoma cells.	Norepinephrine	56-69	neuropeptide Y receptor Y4	Homo sapiens	111-114
21317421-2	2011	Neuropeptide Y (NPY), a sympathetic co-transmitter of norepinephrine, improves contractility in mesenteric arteries of pre-hepatic portal hypertensive rats.	Norepinephrine	54-68	neuropeptide Y	Rattus norvegicus	0-14
21317421-2	2011	Neuropeptide Y (NPY), a sympathetic co-transmitter of norepinephrine, improves contractility in mesenteric arteries of pre-hepatic portal hypertensive rats.	Norepinephrine	54-68	neuropeptide Y	Rattus norvegicus	16-19
21668450-7	2011	Deprivation of glucose or stimulation with adenosine or noradrenaline leads to an increased phosphorylation of PP1-R3F bound GS at Ser640 and Ser644 curtailing glycogen synthesis and facilitating glycogen degradation to provide glucose in astrocytoma cells.	Norepinephrine	56-69	protein phosphatase 1 regulatory subunit 3F	Homo sapiens	115-118
21444155-4	2011	It appears that increased amounts of dopamine and noradrenaline have the ability to inhibit the secretion of growth hormone and growth-related hormones such as prolactin, thyroid hormones, sex hormones and insulin.	Norepinephrine	50-63	growth hormone 1	Homo sapiens	109-123
21419145-7	2011	The levels of basal and serotonin- or norepinephrine-stimulated AVP and OXT secretion in pituicyte cultures prepared from the posterior lobe of the pituitaries were also measured.	Norepinephrine	38-52	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	72-75
21613371-7	2011	Strikingly, responses to phenylephrine and noradrenaline were almost completely abolished in alpha(1A)-AR(-/-) mice.	Norepinephrine	43-56	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	93-101
21444155-5	2011	Therefore, it would be reasonable to suggest that the increases in dopamine and noradrenaline caused by stimulant usage can disrupt the homeostasis of both growth hormone and growth-related hormones, generating the potential for the suppression of growth.	Norepinephrine	80-93	growth hormone 1	Homo sapiens	156-170
21416264-4	2011	The SLC6A2 gene is located on chromosome 16q12.2 and encodes the norepinephrine transporter (NET), responsible for the reuptake of norepinephrine into presynaptic nerve terminals.	Norepinephrine	65-79	solute carrier family 6 member 2	Homo sapiens	4-10
21519229-2	2011	METHODS: Vasopressin was administered at a dose of 0.04 IU   kg-1   h-1 over 4 h in 12 patients with severe sepsis who were receiving norepinephrine.	Norepinephrine	134-148	arginine vasopressin	Homo sapiens	9-20
21545240-4	2011	In a subgroup of 20 patients admitted within 4 h after onset, circulating catestatin correlated inversely with norepinephrine.	Norepinephrine	111-125	chromogranin A	Homo sapiens	74-84
21613676-5	2011	CCl4-intoxication resulted in the injury of vasoactivity which was demonstrated by the inhibition of acetylcholine-induced relaxation as well as noradrenaline-induced contraction.	Norepinephrine	145-158	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
21416264-4	2011	The SLC6A2 gene is located on chromosome 16q12.2 and encodes the norepinephrine transporter (NET), responsible for the reuptake of norepinephrine into presynaptic nerve terminals.	Norepinephrine	65-79	solute carrier family 6 member 2	Homo sapiens	93-96
21362438-2	2011	We previously demonstrated that the major brain norepinephrine (NE)-containing nucleus, locus coeruleus (LC) is more sensitive to stressors and to the stress-related neuropeptide, corticotropin-releasing factor (CRF) in female compared to male rats.	Norepinephrine	48-62	corticotropin releasing hormone	Rattus norvegicus	180-210
21542899-8	2011	However, depletion of norepinephrine was significant after MPTP treatment only in P2X7 knockout mice.	Norepinephrine	22-36	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	82-86
20715173-0	2011	Norepinephrine induces VEGF expression and angiogenesis by a hypoxia-inducible factor-1alpha protein-dependent mechanism.	Norepinephrine	0-14	vascular endothelial growth factor A	Homo sapiens	23-27
20715173-0	2011	Norepinephrine induces VEGF expression and angiogenesis by a hypoxia-inducible factor-1alpha protein-dependent mechanism.	Norepinephrine	0-14	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-92
20715173-5	2011	Treatment of the cells with norepinephrine (NE) or isoproterenol induced VEGF expression and HIF-1alpha protein amount in a dose-dependent manner.	Norepinephrine	28-42	vascular endothelial growth factor A	Homo sapiens	73-77
20715173-5	2011	Treatment of the cells with norepinephrine (NE) or isoproterenol induced VEGF expression and HIF-1alpha protein amount in a dose-dependent manner.	Norepinephrine	28-42	hypoxia inducible factor 1 subunit alpha	Homo sapiens	93-103
21454670-1	2011	The transporters for serotonin (SERT), dopamine, and noradrenaline have a conserved hydrophobic core but divergent N and C termini.	Norepinephrine	53-66	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	21-30
21326108-1	2011	We have recently shown that an appropriate amount of exogenous big endothelin-1 (ET-1) has beneficial effects on ischemia-/reperfusion-induced norepinephrine overflow and cardiac dysfunction in rat hearts and that these effects occur through a conversion to ET-1 by endothelin-converting enzyme and following stimulation of ETB receptor.	Norepinephrine	143-157	endothelin 1	Rattus norvegicus	67-79
21244368-3	2011	Also, the influence of this receptor subtype on angiotensin II (Ang II)-mediated noradrenaline release was evaluated.	Norepinephrine	81-94	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	48-62
21244368-3	2011	Also, the influence of this receptor subtype on angiotensin II (Ang II)-mediated noradrenaline release was evaluated.	Norepinephrine	81-94	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	64-70
21244368-12	2011	Ang II facilitated RNS-induced noradrenaline release in SHAM-WT but not in SHAM-KO and SNx-WT.	Norepinephrine	31-44	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-6
21244368-14	2011	Presynaptic inhibition of noradrenaline release was diminished and the facilitatory effect of presynaptic angiotensin AT1 receptors on noradrenaline release was markedly decreased in renal failure and depended on functioning alpha(2A)-adrenoceptors.	Norepinephrine	135-148	angiotensin II receptor, type 1a	Mus musculus	118-121
21244368-14	2011	Presynaptic inhibition of noradrenaline release was diminished and the facilitatory effect of presynaptic angiotensin AT1 receptors on noradrenaline release was markedly decreased in renal failure and depended on functioning alpha(2A)-adrenoceptors.	Norepinephrine	135-148	adrenergic receptor, alpha 2a	Mus musculus	225-233
21326108-1	2011	We have recently shown that an appropriate amount of exogenous big endothelin-1 (ET-1) has beneficial effects on ischemia-/reperfusion-induced norepinephrine overflow and cardiac dysfunction in rat hearts and that these effects occur through a conversion to ET-1 by endothelin-converting enzyme and following stimulation of ETB receptor.	Norepinephrine	143-157	endothelin 1	Rattus norvegicus	81-85
21326108-6	2011	In addition, N-nitro-l-arginine blunted big ET-1-induced suppression of norepinephrine overflow and improvement of cardiac dysfunction after ischemia/reperfusion.	Norepinephrine	72-86	endothelin 1	Rattus norvegicus	44-48
21330041-7	2011	Noradrenaline plasma concentrations were 23684 +- 5036 pg ml(-1) with adrenaline, 11455 +- 2450 pg ml(-1) with 0.2 U kg(-1) vasopressin, and 12119 +- 2921 pg ml(-1) with 0.8 U kg(-1) vasopressin at 90 s after administration of vasopressors (p < .05 for both doses of vasopressin vs adrenaline).	Norepinephrine	0-13	vasopressin	Sus scrofa	183-194
21344477-0	2011	Differential involvement of noradrenaline and nitric oxide in the regulation of vasopressin and oxytocin expression in rat supraoptic nucleus.	Norepinephrine	28-41	arginine vasopressin	Rattus norvegicus	80-91
21330041-7	2011	Noradrenaline plasma concentrations were 23684 +- 5036 pg ml(-1) with adrenaline, 11455 +- 2450 pg ml(-1) with 0.2 U kg(-1) vasopressin, and 12119 +- 2921 pg ml(-1) with 0.8 U kg(-1) vasopressin at 90 s after administration of vasopressors (p < .05 for both doses of vasopressin vs adrenaline).	Norepinephrine	0-13	vasopressin	Sus scrofa	183-194
21330041-9	2011	CONCLUSIONS: Vasopressin enhances adrenal gland perfusion, but decreases noradrenaline plasma concentration when compared to adrenaline during CPR.	Norepinephrine	73-86	vasopressin	Sus scrofa	13-24
21412203-1	2011	BACKGROUND: The presynaptic norepinephrine transporter (NET) mediates synaptic clearance and recycling of norepinephrine.	Norepinephrine	28-42	solute carrier family 6 member 2	Homo sapiens	56-59
21503156-5	2011	Although the changes observed are less robust than those reported in mice with impaired dopamine, noradrenaline, and serotonin plasma membrane transporters, they suggest that in GABAergic terminals GAT-1 impacts on presynaptic GABA homeostasis, and may contribute to the activity-dependent regulation of inhibitory efficacy.	Norepinephrine	98-111	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	Mus musculus	198-203
21542970-12	2011	The level of norepinephrine in BALF was increased at each time interval in the LPS + yohimbine group, and so did the levels of TNF-alpha, IL-1beta and IL-6 at 6 and 48 hours after LPS administration respectively.	Norepinephrine	13-27	interleukin 1 beta	Rattus norvegicus	138-146
21542970-12	2011	The level of norepinephrine in BALF was increased at each time interval in the LPS + yohimbine group, and so did the levels of TNF-alpha, IL-1beta and IL-6 at 6 and 48 hours after LPS administration respectively.	Norepinephrine	13-27	interleukin 6	Rattus norvegicus	151-155
21470423-7	2011	CONCLUSIONS: Critically ill surgical patients are at an increased risk for fluctuating blood glucose concentrations ranging < 80 mg/dl or >= 150 mg/dl in particular if they are of advanced age and require administration of insulin, noradrenaline, and/or steroids.	Norepinephrine	238-251	insulin	Homo sapiens	229-236
21463021-4	2011	Following strongly reinforced training, retention loss induced by a RyR inhibitor was prevented by a NO donor or noradrenaline (NA).	Norepinephrine	113-126	ryanodine receptor 1	Homo sapiens	68-71
21256578-4	2011	DA-8031 exhibits high affinity and selectivity to the serotonin transporter (Ki value 1.94 nM for 5-hydroxytryptamine transporter, 22 020 nM for norepinephrine transporter, and 77 679 nM for dopamine transporter) and potency to inhibit serotonin reuptake into the rat brain synaptosome in vitro (half maximal inhibitory concentration 6.52 nM for 5-hydroxytryptamine, 30.2 muM for norepinephrine, and 136.9 muM for dopamine).	Norepinephrine	145-159	solute carrier family 6 member 4	Rattus norvegicus	54-75
21262224-8	2011	Preincubation with either the COX-1/2 or COX-2 inhibitor (indomethacin and NS-398, respectively) decreased the noradrenaline contraction in aldosterone-treated animals, while this response was not modified by COX-1 inhibitor SC-560.	Norepinephrine	111-124	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	30-37
21262224-8	2011	Preincubation with either the COX-1/2 or COX-2 inhibitor (indomethacin and NS-398, respectively) decreased the noradrenaline contraction in aldosterone-treated animals, while this response was not modified by COX-1 inhibitor SC-560.	Norepinephrine	111-124	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	30-35
21129745-3	2011	Concomitant treatment with PDGF-BB (10-300 nM) and ET-1 (30 nM-1 muM) dose-dependently suppressed contractile responses to high K(+) and norepinephrine.	Norepinephrine	137-151	endothelin 1	Rattus norvegicus	51-55
21059985-9	2011	Reduction in nAChR antibody titer resulted in a decrease in orthostatic hypotension, an increased concentration of upright plasma norepinephrine, improvement in some sweat function, and improvement in symptoms.	Norepinephrine	130-144	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	13-18
21156805-4	2011	The alpha(1)-adrenergic receptor agonist norepinephrine selectively activates PKD1, thrombin and PDGF selectively activate PKD2, and endothelin-1 and PMA activate both PKD1 and PKD2.	Norepinephrine	41-55	coagulation factor II, thrombin	Homo sapiens	84-92
21156805-4	2011	The alpha(1)-adrenergic receptor agonist norepinephrine selectively activates PKD1, thrombin and PDGF selectively activate PKD2, and endothelin-1 and PMA activate both PKD1 and PKD2.	Norepinephrine	41-55	polycystin 2, transient receptor potential cation channel	Homo sapiens	123-127
21156805-4	2011	The alpha(1)-adrenergic receptor agonist norepinephrine selectively activates PKD1, thrombin and PDGF selectively activate PKD2, and endothelin-1 and PMA activate both PKD1 and PKD2.	Norepinephrine	41-55	endothelin 1	Homo sapiens	133-145
21156805-4	2011	The alpha(1)-adrenergic receptor agonist norepinephrine selectively activates PKD1, thrombin and PDGF selectively activate PKD2, and endothelin-1 and PMA activate both PKD1 and PKD2.	Norepinephrine	41-55	polycystin 2, transient receptor potential cation channel	Homo sapiens	177-181
21129446-1	2011	Norepinephrine and serotonin involvement in nociceptive functions is supported by observations of analgesic effects of norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitors such as amitriptyline.	Norepinephrine	0-14	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	156-177
21129446-1	2011	Norepinephrine and serotonin involvement in nociceptive functions is supported by observations of analgesic effects of norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitors such as amitriptyline.	Norepinephrine	0-14	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	179-183
21145919-10	2011	The distinct colocalization of neuronal Ang II with DbetaH in the heart may indicate that Ang II participates together with norepinephrine in the regulation of cardiac functions: produced as a cardiac neurotransmitter Ang II may have inotropic, chronotropic or dromotropic effects in atria and ventricles and contributes to blood pressure regulation.	Norepinephrine	124-138	angiotensinogen	Homo sapiens	40-46
21146475-10	2011	The bradycardiac response to noradrenaline microinjection into the IC was abolished by pretreatment with either pentolinium or the V(1)-vasopressin receptor antagonist, indicating its reflex origin.	Norepinephrine	29-42	arginine vasopressin	Rattus norvegicus	136-147
21146475-11	2011	In conclusion, our results suggest that pressor response evoked by microinjection of noradrenaline into the IC involve the activation of IC alpha(1)-adrenoceptors to cause the release of vasopressin into the circulation.	Norepinephrine	85-98	arginine vasopressin	Rattus norvegicus	187-198
21114976-3	2011	Angiotensin II and bradykinin enhanced noradrenaline release evoked by 100 pulses at 2Hz, in a concentration-dependent manner, in both vessels.	Norepinephrine	39-52	angiotensinogen	Rattus norvegicus	0-14
20974189-6	2011	Strikingly, only heterozygous serotonin transporter knockout pups experiencing high maternal care showed increased hippocampal levels of serotonin and norepinephrine and decreased serotonin turnover compared to wild-type littermates.	Norepinephrine	151-165	solute carrier family 6 member 4	Homo sapiens	30-51
21048781-1	2011	Endothelin-1 (ET-1) is involved in norepinephrine (NE) overflow and cardiac dysfunction after myocardial ischemia/reperfusion via the activation of ET(A) receptors.	Norepinephrine	35-49	endothelin 1	Rattus norvegicus	0-12
21044118-10	2011	Increased plasma CgA levels were positively correlated with urinary excretion rates of noradrenaline (r = 0 68, P = 0 005) and normetanephrine (r = 0 68, P = 0 005).	Norepinephrine	87-100	chromogranin A	Homo sapiens	17-20
21401511-6	2011	Recent preliminary studies with selective noradrenaline or serotonin neurotoxins suggest also involvement of the brain noradrenergic and serotonergic systems in the regulation of liver CYP.	Norepinephrine	42-55	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	185-188
21401511-7	2011	Moreover, the influence of the peripheral nervous system involving several neurotransmitters (acetylcholine, noradrenaline, adrenaline, dopamine, serotonin) on liver function may also be important for the physiological regulation of hepatic CYP activity.	Norepinephrine	109-122	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	241-244
21347440-1	2011	We recently demonstrated, in rat brain slices, that the usual excitation by noradrenaline (NA) of hypocretin/orexin (hcrt/orx) neurons was changed to an inhibition following sleep deprivation (SD).	Norepinephrine	76-89	hypocretin neuropeptide precursor	Rattus norvegicus	98-115
21048781-1	2011	Endothelin-1 (ET-1) is involved in norepinephrine (NE) overflow and cardiac dysfunction after myocardial ischemia/reperfusion via the activation of ET(A) receptors.	Norepinephrine	35-49	endothelin 1	Rattus norvegicus	14-18
19760428-8	2011	Correlations between serum levels of CgA and catecholamines (adrenaline, noradrenaline and dopamine) were evident for hyperthermia (R = 0.632-0.757, p < 0.05 to <0.01), but there was no significant correlation between CgA and catecholamine levels in CSF.	Norepinephrine	73-86	chromogranin A	Homo sapiens	37-40
20868698-8	2011	In addition, NPY induced a stepped increase of norepinephrine (NE) outflow in the NAc area.	Norepinephrine	47-61	neuropeptide Y	Rattus norvegicus	13-16
21051529-5	2011	We found that norepinephrine activates the PI3K/Akt/GSK-3beta pathway to concurrently enhance alpha(1C)-protein translation and block its polyubiquitination and proteasomal degradation.	Norepinephrine	14-28	AKT serine/threonine kinase 1	Rattus norvegicus	48-51
21051529-9	2011	The antagonism of two upstream kinases, PI3K and Akt, inhibits the induction of alpha(1C)-protein by norepinephrine.	Norepinephrine	101-115	AKT serine/threonine kinase 1	Rattus norvegicus	49-52
20733009-10	2011	5-Aza-2"-deoxycytidine inhibited the norepinephrine-induced increase in methylation of the Egr-1 binding site and restored Egr-1 binding and PKCepsilon gene expression to the control levels.	Norepinephrine	37-51	early growth response 1	Rattus norvegicus	91-96
20733009-10	2011	5-Aza-2"-deoxycytidine inhibited the norepinephrine-induced increase in methylation of the Egr-1 binding site and restored Egr-1 binding and PKCepsilon gene expression to the control levels.	Norepinephrine	37-51	early growth response 1	Rattus norvegicus	123-128
20733009-10	2011	5-Aza-2"-deoxycytidine inhibited the norepinephrine-induced increase in methylation of the Egr-1 binding site and restored Egr-1 binding and PKCepsilon gene expression to the control levels.	Norepinephrine	37-51	protein kinase C, epsilon	Rattus norvegicus	141-151
22178948-2	2011	We describe differences in the regulation of UCP-1 mRNA expression between rat and mouse brown adipocytes in culture, using norepinephrine (NE), triiodothyronine (T3), insulin and retinoic acid (RA).	Norepinephrine	124-138	uncoupling protein 1	Rattus norvegicus	45-50
20637865-8	2011	Both, isoproterenol and norepinephrine (non-selective b-AR agonists), as well as salbutamol (selective b(2)-AR agonist) increased autophagic flux, and these effects were blocked by propanolol (b-AR antagonist), ICI-118,551 (selective b(2)-AR antagonist), 3-methyladenine but not by atenolol (selective b(1)-AR antagonist).	Norepinephrine	24-38	adrenoceptor beta 1	Rattus norvegicus	302-309
21113619-2	2011	VP secretion is under a noradrenaline control, whereas the regulation of TH expression remains uncertain.	Norepinephrine	24-37	arginine vasopressin	Rattus norvegicus	0-2
21113619-8	2011	OS combined with prazosin administration resulted in an increased level of VP mRNA on P3 and P13, but not on E21 suggesting the onset of the noradrenaline inhibitory control after birth.	Norepinephrine	141-154	arginine vasopressin	Rattus norvegicus	75-77
21113619-10	2011	Thus, VP neurons begin to react to OS by an increased VP synthesis at the end of fetal life and by the onset of TH expression shortly after birth; the expression of both substances appears to be under the inhibitory control of noradrenaline.	Norepinephrine	227-240	arginine vasopressin	Rattus norvegicus	6-8
21441617-0	2011	Noradrenaline release in rodent tissues is inhibited by interleukin-1beta but is not affected by urotensin II, MCH, NPW and NPFF.	Norepinephrine	0-13	interleukin 1 beta	Mus musculus	56-73
21474921-6	2011	Since adrenergic agonists and dibutyryl-cAMP induce PDE10A mRNA, the in vitro clock-dependent control of Pde10a appears to be mediated via a norepinephrine   beta-adrenoceptor   cAMP/protein kinase A signaling pathway.	Norepinephrine	141-155	phosphodiesterase 10A	Rattus norvegicus	105-111
21441617-3	2011	In mouse brain cortex, interleukin-1beta at 0.3 nM and the prostaglandin E2 analogue sulprostone at 3 nM inhibited noradrenaline release by about 40% the effect of interleukin-1beta developed gradually, whereas the effect of sulprostone occurred promptly.	Norepinephrine	115-128	interleukin 1 beta	Mus musculus	23-40
22216270-13	2011	Pretreatment with pH 5.0 QX-314, and not pH 7.4 QX-314, alleviated pain behavior, inhibited the increased spinal Fos protein and p-ERK expression induced by pH 5.0 PBS or norepinephrine, blocked sodium currents and abolished the production of action potentials evoked by current injection.	Norepinephrine	171-185	mitogen-activated protein kinase 1	Mus musculus	131-134
21051559-7	2011	Large increases of plasma dopamine and its metabolites additionally characterised patients with PPGLs due to the latter mutations, whereas patients with NF1 were characterised by large increases in plasma dihydroxyphenylglycol and dihydroxyphenylacetic acid, the deaminated metabolites of noradrenaline and dopamine.	Norepinephrine	289-302	neurofibromin 1	Homo sapiens	153-156
20666638-4	2011	Suppressed responsiveness of parvocellular paraventricular nucleus (pPVN) corticotropin-releasing hormone neurons, and hence the HPA axis, following IL-1beta in late pregnancy is evidently explained by presynaptic inhibition of noradrenaline release in the pPVN, owing to increased endogenous opioid peptide enkephalin production in brainstem nucleus tractus solitarii neurons.	Norepinephrine	228-241	corticotropin releasing hormone	Rattus norvegicus	74-105
20666638-4	2011	Suppressed responsiveness of parvocellular paraventricular nucleus (pPVN) corticotropin-releasing hormone neurons, and hence the HPA axis, following IL-1beta in late pregnancy is evidently explained by presynaptic inhibition of noradrenaline release in the pPVN, owing to increased endogenous opioid peptide enkephalin production in brainstem nucleus tractus solitarii neurons.	Norepinephrine	228-241	interleukin 1 beta	Rattus norvegicus	149-157
21293101-8	2011	RESULTS: Stimulation of human prostate tissue with noradrenaline (30 muM) or phenylephrine (10 muM) resulted in ERK activation.	Norepinephrine	51-64	mitogen-activated protein kinase 1	Homo sapiens	112-115
20826776-4	2010	Norepinephrine (NE) treatment of ovarian cancer cells resulted in a 250-300% increase in IL8 protein and 240-320% increase in its mRNA levels.	Norepinephrine	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	89-92
20954794-1	2010	The alpha(1)-adrenergic receptor (AR) subtypes (alpha(1a), alpha(1b), and alpha(1d)) mediate several physiological effects of epinephrine and norepinephrine.	Norepinephrine	142-156	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	48-56
20837485-9	2010	We conclude that partial agonism of norepinephrine at the beta(2)AR is related to the induction of a different active conformation and that this conformation is efficient in signaling to G(s) and less efficient in signaling to beta-arrestin2.	Norepinephrine	36-50	arrestin beta 2	Homo sapiens	227-241
21042571-1	2010	Neuropeptide Y (NPY), colocalized with norepinephrine neuron, is known to modulate sympathetic activity and feeding behavior.	Norepinephrine	39-53	neuropeptide Y	Rattus norvegicus	0-14
20602110-8	2010	The R-848-induced TNF-alpha production in RAW264 cells was significantly inhibited by epinephrine and norepinephrine pre-treatment, although IFN-alpha was not detected.	Norepinephrine	102-116	tumor necrosis factor	Mus musculus	18-27
21099335-5	2010	RESULTS: Arginine stimulated both glucagon and SST release from control mouse islets whereas the sympathetic neurotransmitter noradrenaline (NA) increased glucagon secretion but inhibited SST release in the presence of 2 mmol/l glucose or 20 mmol/l arginine.	Norepinephrine	126-139	somatostatin	Mus musculus	188-191
21042571-1	2010	Neuropeptide Y (NPY), colocalized with norepinephrine neuron, is known to modulate sympathetic activity and feeding behavior.	Norepinephrine	39-53	neuropeptide Y	Rattus norvegicus	16-19
20493668-3	2010	The principal aim of this study was to re-examine the status of platelet membrane GRK2 protein in patients with MDD, along with GRK3 (a close kinase homolog) and GRK5 (a kinase with different properties), before and after treatment with serotonin-selective reuptake inhibitor (SSRI) or serotonin noradrenaline reuptake inhibitor (SNRI) antidepressants.	Norepinephrine	296-309	G protein-coupled receptor kinase 2	Homo sapiens	82-86
20503062-2	2010	To assess the functional role of adrenergic signaling in the auditory periphery, we studied mice with targeted deletion of the gene for dopamine beta-hydroxylase (DBH), which catalyzes the conversion of dopamine to noradrenaline; thus, these mutant mice have no measurable adrenaline or noradrenaline.	Norepinephrine	215-228	dopamine beta hydroxylase	Mus musculus	136-161
20874043-7	2010	However, results of the a priori subgroup and post hoc analyses of this trial suggest that patients may benefit if arginine vasopressin is used in patients with less severe shock, defined as those receiving a relatively low norepinephrine-equivalent dose of 5-14 mug/minute, or in those at risk for renal failure.	Norepinephrine	224-238	arginine vasopressin	Homo sapiens	124-135
20874043-8	2010	Current guidelines from the Surviving Sepsis Campaign recommend arginine vasopressin 0.03 unit/minute may be added to norepinephrine with the anticipation of an effect equal to higher doses of norepinephrine alone.	Norepinephrine	193-207	arginine vasopressin	Homo sapiens	73-84
20412850-2	2010	In murine thymocytes, Thy-1 is downregulated in response to norepinephrine (NE) through posttranscriptional destabilization of its mRNA mediated by betaAR/AC/cAMP/PKA signaling.	Norepinephrine	60-74	thymus cell antigen 1, theta	Mus musculus	22-27
20600439-3	2010	In the present work we sought to define the endothelin receptors and intracellular mechanisms involved in the down-regulation of neuronal norepinephrine uptake induced by endothelin-1 and -3 in the rat posterior hypothalamic region.	Norepinephrine	138-152	endothelin 1	Rattus norvegicus	44-54
20600439-3	2010	In the present work we sought to define the endothelin receptors and intracellular mechanisms involved in the down-regulation of neuronal norepinephrine uptake induced by endothelin-1 and -3 in the rat posterior hypothalamic region.	Norepinephrine	138-152	endothelin 1	Rattus norvegicus	171-190
20600439-4	2010	Results showed that endothelin-1 reduced norepinephrine uptake through ET(B) receptors, whereas endothelin-3 through a non-conventional or atypical endothelin receptor.	Norepinephrine	41-55	endothelin 1	Rattus norvegicus	20-32
20511415-10	2010	Acetylcholine and bradykinin relaxed norepinephrine preconstrictions by approximately 20% and approximately 40%, respectively.	Norepinephrine	37-51	kininogen 1	Homo sapiens	18-28
20605057-0	2010	Dexamethasone enhances the norepinephrine-induced ERK/MAPK intracellular pathway possibly via dysregulation of the alpha2-adrenergic receptor: implications for antidepressant drug mechanism of action.	Norepinephrine	27-41	mitogen-activated protein kinase 1	Homo sapiens	50-53
20519139-2	2010	administered corticotropin-releasing factor (CRF) (0.5-3.0 nmol/animal) dose-dependently elevates plasma noradrenaline and adrenaline through brain phospholipase C-, diacylglycerol lipase- and prostanoids-mediated mechanisms in rats.	Norepinephrine	105-118	corticotropin releasing hormone	Rattus norvegicus	13-43
20503062-2	2010	To assess the functional role of adrenergic signaling in the auditory periphery, we studied mice with targeted deletion of the gene for dopamine beta-hydroxylase (DBH), which catalyzes the conversion of dopamine to noradrenaline; thus, these mutant mice have no measurable adrenaline or noradrenaline.	Norepinephrine	215-228	dopamine beta hydroxylase	Mus musculus	163-166
20503062-2	2010	To assess the functional role of adrenergic signaling in the auditory periphery, we studied mice with targeted deletion of the gene for dopamine beta-hydroxylase (DBH), which catalyzes the conversion of dopamine to noradrenaline; thus, these mutant mice have no measurable adrenaline or noradrenaline.	Norepinephrine	287-300	dopamine beta hydroxylase	Mus musculus	163-166
20212497-3	2010	We hypothesized that consumption of an HF diet activates HPA axis by increasing norepinephrine (NE) in the paraventricular nucleus (PVN) of the hypothalamus, leading to elevation in corticotrophin-releasing hormone (CRH) concentration in the median eminence (ME) resulting in elevated serum corticosterone (CORT).	Norepinephrine	80-94	corticotropin releasing hormone	Rattus norvegicus	182-214
20810904-0	2010	Norepinephrine promotes microglia to uptake and degrade amyloid beta peptide through upregulation of mouse formyl peptide receptor 2 and induction of insulin-degrading enzyme.	Norepinephrine	0-14	insulin degrading enzyme	Mus musculus	150-174
20434498-0	2010	Interactions between orexin-immunoreactive fibers and adrenaline or noradrenaline-expressing neurons of the lower brainstem in rats and mice.	Norepinephrine	68-81	hypocretin neuropeptide precursor	Rattus norvegicus	21-27
20529667-8	2010	Therefore, ischemia-reperfusion may increase the cerebrovascular responsiveness to noradrenaline, through upregulation of alpha-adrenoceptors and increased COX-2-derived PGI(2) exerting a vasoconstrictor action.	Norepinephrine	83-96	cytochrome c oxidase subunit II	Capra hircus	156-161
20739551-0	2010	Insulin reveals Akt signaling as a novel regulator of norepinephrine transporter trafficking and norepinephrine homeostasis.	Norepinephrine	54-68	thymoma viral proto-oncogene 1	Mus musculus	16-19
20547972-4	2010	Intracerebroventricular infusion of minocycline, an anti-inflammatory antibiotic, caused a significant attenuation of mean arterial pressure, cardiac hypertrophy, and plasma norepinephrine induced by chronic angiotensin II infusion.	Norepinephrine	174-188	angiotensinogen	Rattus norvegicus	208-222
20231847-7	2010	RESULTS: NPFF counteracted noradrenaline-induced lipolysis, which was more marked after 48 h than after 4 h exposure and was solely attributed to inhibition of beta-adrenoceptor signalling.	Norepinephrine	27-40	neuropeptide FF-amide peptide precursor	Homo sapiens	9-13
20406625-12	2010	PDE4, but not PDE3, controls the atrial inotropic and cAMP beta(1)-adrenoceptor-mediated responses to (-)-noradrenaline.	Norepinephrine	102-119	phosphodiesterase 4A	Homo sapiens	0-4
20190098-10	2010	The lack of p75(NTR) also resulted in increased tyrosine hydroxylase content in cardiac sympathetic neurons and elevated norepinephrine in the right ventricle, where innervation density was normal.	Norepinephrine	121-135	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	12-15
20361987-0	2010	Noradrenaline acting at beta-adrenoceptors induces expression of IL-1beta and its negative regulators IL-1ra and IL-1RII, and drives an overall anti-inflammatory phenotype in rat cortex.	Norepinephrine	0-13	interleukin 1 beta	Rattus norvegicus	65-73
20190098-10	2010	The lack of p75(NTR) also resulted in increased tyrosine hydroxylase content in cardiac sympathetic neurons and elevated norepinephrine in the right ventricle, where innervation density was normal.	Norepinephrine	121-135	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	16-19
20100531-1	2010	In vitro and in vivo studies demonstrated that nociceptin/orphanin FQ inhibits norepinephrine release, while the effects of norepinephrine on nociceptin/orphanin FQ release remain unknown.	Norepinephrine	79-93	prepronociceptin	Homo sapiens	47-57
20083574-1	2010	AIMS: alpha(2)-Adrenoceptors modulate cardiovascular function by vasoconstriction or dilatation, by central inhibition of sympathetic activity, or by feedback inhibition of norepinephrine release from sympathetic neurons.	Norepinephrine	173-187	adrenergic receptor, alpha 2a	Mus musculus	6-28
20083574-10	2010	In primary sympathetic neurons from Dbh-alpha(2A) transgenic mice, norepinephrine and medetomidine induced endocytosis of alpha(2A)-adrenoceptors into neurite processes.	Norepinephrine	67-81	dopamine beta hydroxylase	Mus musculus	36-39
20083574-10	2010	In primary sympathetic neurons from Dbh-alpha(2A) transgenic mice, norepinephrine and medetomidine induced endocytosis of alpha(2A)-adrenoceptors into neurite processes.	Norepinephrine	67-81	adrenergic receptor, alpha 2a	Mus musculus	40-48
20083574-10	2010	In primary sympathetic neurons from Dbh-alpha(2A) transgenic mice, norepinephrine and medetomidine induced endocytosis of alpha(2A)-adrenoceptors into neurite processes.	Norepinephrine	67-81	adrenergic receptor, alpha 2a	Mus musculus	122-130
20083574-11	2010	CONCLUSION: alpha(2A)-Adrenoceptors expressed in adrenergic cells are essential feedback inhibitors of sympathetic norepinephrine release to prevent cardiac hypertrophy and fibrosis at baseline.	Norepinephrine	115-129	adrenergic receptor, alpha 2a	Mus musculus	12-20
19936638-11	2010	Sympathectomy induced a significant increase in dura mater NO levels and VIP decreased NO to control levels and increased the norepinephrine vessel-contraction responses of sympathectomized rats.	Norepinephrine	126-140	vasoactive intestinal peptide	Rattus norvegicus	73-76
19155075-8	2010	Concentrations of uric acid, epinephrine, and norepinephrine also correlated with ANP and BNP.	Norepinephrine	46-60	natriuretic peptide A	Homo sapiens	82-85
20228120-5	2010	The hypertensive response to Ang II was greatest in rats on the high-salt diet (Ang II-salt hypertension), which was associated with increased "whole body" sympathetic activity as measured by noradrenaline spillover and ganglionic blockade.	Norepinephrine	192-205	angiotensinogen	Rattus norvegicus	29-35
20193660-2	2010	In RTT patients and Mecp2-null (Mecp2(-/Y)) mice, norepinephrine (NE) content drops significantly, which may play a role in breathing arrhythmia, sleep disorders and sudden death.	Norepinephrine	50-64	methyl-CpG binding protein 2	Homo sapiens	20-25
20193660-2	2010	In RTT patients and Mecp2-null (Mecp2(-/Y)) mice, norepinephrine (NE) content drops significantly, which may play a role in breathing arrhythmia, sleep disorders and sudden death.	Norepinephrine	50-64	methyl-CpG binding protein 2	Homo sapiens	32-37
20147605-5	2010	Bath norepinephrine stimulated chloride transport (from a basal transport rate of 298.1 +/- 31.7 to 425.2 +/- 45.8 pmol.mm(-1).min(-1); P < 0.05) and completely prevented the inhibition in chloride transport by ANG II.	Norepinephrine	5-19	angiotensinogen	Rattus norvegicus	214-220
20147605-7	2010	In the presence of 10(-5) M propranolol, the effect of norepinephrine to prevent the inhibition of chloride transport by ANG II was still present.	Norepinephrine	55-69	angiotensinogen	Rattus norvegicus	121-127
20491280-3	2010	The purpose of this study was to determine whether norepinephrine transporter (NET) gene and serotonin transporter (5-HTT) gene polymorphisms are associated with the antidepressant response to milnacipran, a serotonin and norepinephrine reuptake inhibitor.	Norepinephrine	51-65	solute carrier family 6 member 2	Homo sapiens	79-82
19538471-1	2010	By employing a pharmacological approach, we have shown that phospholipase C (PLC) activity is involved in the regulation of gene expression of transcription factors such as c-Fos and c-Jun in cardiomyocytes in response to norepinephrine (NE).	Norepinephrine	222-236	PYD and CARD domain containing	Homo sapiens	170-174
20170659-8	2010	The promoter assay with overexpression of sXBP1 or norepinephrine showed that the proximal AP1/CRE-like element in the promoter region of BNP was critical for transcriptional regulation of BNP by sXBP1.	Norepinephrine	51-65	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	91-94
20351116-7	2010	At 4 weeks post-MI, plasma levels of both norepinephrine and epinephrine were reduced in PNMT-driven GRK2 KO, compared with control mice, suggesting markedly reduced post-MI sympathetic activation.	Norepinephrine	42-56	phenylethanolamine-N-methyltransferase	Mus musculus	89-93
20122921-2	2010	Recently, chronic psychosocial stress as animal model of depression has been shown to stimulate CREB transcriptional activity in the brain; this stimulation was prevented by treatment with the antidepressant imipramine, which inhibits both noradrenaline and serotonin reuptake.	Norepinephrine	240-253	cAMP responsive element binding protein 1	Mus musculus	96-100
20188818-0	2010	Noradrenaline increases the expression and release of Hsp72 by human neutrophils.	Norepinephrine	0-13	heat shock protein family A (Hsp70) member 1A	Homo sapiens	54-59
20188818-3	2010	The aim of the present study was to evaluate the role of noradrenaline (NA) as a stress signal on the expression and release of Hsp72 by circulating neutrophils (as a source), all within a context of the immunophysiological regulation during exercise-induced stress in sedentary and healthy young (21-26years) women.	Norepinephrine	57-70	heat shock protein family A (Hsp70) member 1A	Homo sapiens	128-133
20100531-1	2010	In vitro and in vivo studies demonstrated that nociceptin/orphanin FQ inhibits norepinephrine release, while the effects of norepinephrine on nociceptin/orphanin FQ release remain unknown.	Norepinephrine	79-93	prepronociceptin	Homo sapiens	58-69
20100531-6	2010	Norepinephrine changes in response to hyperventilation in groups 1 and 3 were directly (P<0.01) correlated with those of nociceptin/orphanin FQ.	Norepinephrine	0-14	prepronociceptin	Homo sapiens	124-134
20100531-6	2010	Norepinephrine changes in response to hyperventilation in groups 1 and 3 were directly (P<0.01) correlated with those of nociceptin/orphanin FQ.	Norepinephrine	0-14	prepronociceptin	Homo sapiens	135-146
20028987-2	2010	Examining precursors from the purest white adipose tissue depot (epididymal), we report here that chronic treatment with the peroxisome proliferator-activated receptor gamma agonist rosiglitazone promotes not only the expression of PGC-1alpha and mitochondriogenesis in these cells but also a norepinephrine-augmentable UCP1 gene expression in a significant subset of the cells, providing these cells with a genuine thermogenic capacity.	Norepinephrine	293-307	peroxisome proliferator activated receptor gamma	Homo sapiens	125-173
19958792-3	2010	Tyrosine hydroxylase (TH) is the initial and rate-limiting enzyme in the biosynthesis of catecholamines such as dopamine and norepinephrine, which are deeply involved in human mental functions and behaviors.	Norepinephrine	125-139	tyrosine hydroxylase	Homo sapiens	0-20
19958792-3	2010	Tyrosine hydroxylase (TH) is the initial and rate-limiting enzyme in the biosynthesis of catecholamines such as dopamine and norepinephrine, which are deeply involved in human mental functions and behaviors.	Norepinephrine	125-139	tyrosine hydroxylase	Homo sapiens	22-24
20010111-1	2010	BACKGROUND: We previously found a severe impairment of cardiac uptake of I-metaiodobenzylguanidine (MIBG), an analogue of norepinephrine, on myocardial scintigraphy in a small group of patients with cardiac syndrome X (CSX), suggesting a dysfunction of cardiac adrenergic nerve fibres.	Norepinephrine	122-136	NK2 homeobox 5	Homo sapiens	219-222
20203201-10	2010	Importantly, treatment of Gsn(-/-) synaptosomes with mycotoxin cytochalasin D, which, like gelsolin, produces actin disassembly, decreased enhanced Ca(2+) influx and subsequent exocytotic norepinephrine release to wild-type levels.	Norepinephrine	188-202	gelsolin	Mus musculus	26-29
19933420-1	2010	Neuropeptide Y (NPY) is a cotransmitter with norepinephrine (NE) and ATP in sympathetic nerves.	Norepinephrine	45-59	neuropeptide Y	Rattus norvegicus	0-14
20004705-2	2010	It has been suggested that endogenous interleukin-1beta (IL-1beta) is involved in norepinephrine (NE)-induced release of corticotropin-releasing hormone (CRH) from the paraventricular nucleus of the hypothalamus (PVN).	Norepinephrine	82-96	interleukin 1 beta	Rattus norvegicus	38-55
20004705-2	2010	It has been suggested that endogenous interleukin-1beta (IL-1beta) is involved in norepinephrine (NE)-induced release of corticotropin-releasing hormone (CRH) from the paraventricular nucleus of the hypothalamus (PVN).	Norepinephrine	82-96	interleukin 1 beta	Rattus norvegicus	57-65
20004705-2	2010	It has been suggested that endogenous interleukin-1beta (IL-1beta) is involved in norepinephrine (NE)-induced release of corticotropin-releasing hormone (CRH) from the paraventricular nucleus of the hypothalamus (PVN).	Norepinephrine	82-96	corticotropin releasing hormone	Rattus norvegicus	121-152
20004705-2	2010	It has been suggested that endogenous interleukin-1beta (IL-1beta) is involved in norepinephrine (NE)-induced release of corticotropin-releasing hormone (CRH) from the paraventricular nucleus of the hypothalamus (PVN).	Norepinephrine	82-96	corticotropin releasing hormone	Rattus norvegicus	154-157
19944679-4	2010	The results indicated that AVP improved the reactivity of superior mesenteric artery and VSMC to norepinephrine and calcium following hemorrhagic shock and hypoxia.	Norepinephrine	97-111	arginine vasopressin	Rattus norvegicus	27-30
19933420-1	2010	Neuropeptide Y (NPY) is a cotransmitter with norepinephrine (NE) and ATP in sympathetic nerves.	Norepinephrine	45-59	neuropeptide Y	Rattus norvegicus	16-19
20606409-14	2010	Many small clinical studies of vasopressin infusion in septic shock have shown that vasopressin infusion increases blood pressure, decreases requirements for norepinephrine and improves renal function.	Norepinephrine	158-172	arginine vasopressin	Homo sapiens	31-42
19880537-9	2010	Noradrenaline uptake into cardiac nerves was significantly lower in gp130 knockout mice, contributing to the lack of neuronal NA stores.	Norepinephrine	0-13	interleukin 6 signal transducer	Mus musculus	68-73
18794888-6	2010	Neurochemical analysis revealed that Slitrk1-knockout mice had increased levels of norepinephrine and its metabolite 3-methoxy-4-hydroxyphenylglycol.	Norepinephrine	83-97	SLIT and NTRK-like family, member 1	Mus musculus	37-44
19800336-10	2010	CONCLUSIONS: The peripheral stress mediator norepinephrine induces visceral hypersensitivity to colorectal distension in response to HeCS by increasing the expression of NGF in the colon wall, which sensitizes primary afferents in the absence of an inflammatory response.	Norepinephrine	44-58	nerve growth factor	Homo sapiens	170-173
19503019-2	2010	Adrenal glucocorticoid stimulates phenylethanolamine N-methyltransferase (PNMT) to convert norepinephrine to epinephrine in the adrenal medulla.	Norepinephrine	91-105	phenylethanolamine-N-methyltransferase	Mus musculus	34-72
19503019-2	2010	Adrenal glucocorticoid stimulates phenylethanolamine N-methyltransferase (PNMT) to convert norepinephrine to epinephrine in the adrenal medulla.	Norepinephrine	91-105	phenylethanolamine-N-methyltransferase	Mus musculus	74-78
19818755-0	2010	Noradrenaline induces IL-1ra and IL-1 type II receptor expression in primary glial cells and protects against IL-1beta-induced neurotoxicity.	Norepinephrine	0-13	interleukin 1 receptor type 2	Rattus norvegicus	33-54
19818755-0	2010	Noradrenaline induces IL-1ra and IL-1 type II receptor expression in primary glial cells and protects against IL-1beta-induced neurotoxicity.	Norepinephrine	0-13	interleukin 1 beta	Rattus norvegicus	110-118
19818755-8	2010	Our results demonstrate that the ability of noradrenaline to induce IL-1ra and IL-1RII is mediated via beta-adrenoceptor activation and downstream activation of protein kinase A and extracellular signal-regulated kinase (ERK).	Norepinephrine	44-57	Eph receptor B1	Rattus norvegicus	182-219
19818755-8	2010	Our results demonstrate that the ability of noradrenaline to induce IL-1ra and IL-1RII is mediated via beta-adrenoceptor activation and downstream activation of protein kinase A and extracellular signal-regulated kinase (ERK).	Norepinephrine	44-57	Eph receptor B1	Rattus norvegicus	221-224
19818755-9	2010	In parallel with its ability to increase IL-1ra and IL-1RII, noradrenaline prevented neurotoxicity in cortical primary neurons induced by conditioned medium from IL-1beta treated mixed glial cells.	Norepinephrine	61-74	interleukin 1 beta	Rattus norvegicus	162-170
19717492-4	2010	Angiotensin II increases whole-body noradrenaline (NA) spillover and depressor responses to ganglionic blockade in rats consuming a high-salt diet, but not in rats on a normal-salt diet.	Norepinephrine	36-49	angiotensinogen	Rattus norvegicus	0-14
20606409-14	2010	Many small clinical studies of vasopressin infusion in septic shock have shown that vasopressin infusion increases blood pressure, decreases requirements for norepinephrine and improves renal function.	Norepinephrine	158-172	arginine vasopressin	Homo sapiens	84-95
20595783-0	2010	Noradrenaline induces clock gene Per1 mRNA expression in C6 glioma cells through beta(2)-adrenergic receptor coupled with protein kinase A - cAMP response element binding protein (PKA-CREB) and Src-tyrosine kinase - glycogen synthase kinase-3beta (Src-GSK-3beta).	Norepinephrine	0-13	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	194-197
20595783-0	2010	Noradrenaline induces clock gene Per1 mRNA expression in C6 glioma cells through beta(2)-adrenergic receptor coupled with protein kinase A - cAMP response element binding protein (PKA-CREB) and Src-tyrosine kinase - glycogen synthase kinase-3beta (Src-GSK-3beta).	Norepinephrine	0-13	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	248-251
20150881-2	2010	In this work we investigate whether norepinephrine (NE) modifies the vasoactive intestinal peptide (VIP) or neuropeptide Y (NPY) actions in coeliac ganglion (CG) on the ovarian hormone release, and evaluate the participation of nitric oxide (NO), measured as nitrite, and of inducible nitric oxide synthetase (iNOS) protein, nerve growth factor (NGF) and its trkA receptor gene expression in the ovarian response.	Norepinephrine	36-50	vasoactive intestinal peptide	Rattus norvegicus	100-103
19564136-2	2009	In a previous study, we reported that noradrenaline (NA) microinjection into the dPAG of rats caused pressor response that was mediated by vasopressin release.	Norepinephrine	38-51	arginine vasopressin	Rattus norvegicus	139-150
19968887-4	2009	RESULTS: The activation of naive CD8+ T lymphocytes by CD3/CD28 cross-linking was inhibited by norepinephrine and dopamine, which was caused by a downregulation of interleukin (IL)-2 expression via Erk1/2 and NF-kappaB inhibition.	Norepinephrine	95-109	interleukin 2	Homo sapiens	164-182
19968887-4	2009	RESULTS: The activation of naive CD8+ T lymphocytes by CD3/CD28 cross-linking was inhibited by norepinephrine and dopamine, which was caused by a downregulation of interleukin (IL)-2 expression via Erk1/2 and NF-kappaB inhibition.	Norepinephrine	95-109	mitogen-activated protein kinase 3	Homo sapiens	198-204
19968887-7	2009	With regard to extravasation we found norepinephrine to induce adhesion of activated CD8+ T cells: norepinephrine increased the interleukin-8 release from endothelium, which in turn had effect on the activated CXCR1+ CD8+ T cells.	Norepinephrine	38-52	C-X-C motif chemokine ligand 8	Homo sapiens	128-141
19968887-7	2009	With regard to extravasation we found norepinephrine to induce adhesion of activated CD8+ T cells: norepinephrine increased the interleukin-8 release from endothelium, which in turn had effect on the activated CXCR1+ CD8+ T cells.	Norepinephrine	99-113	C-X-C motif chemokine ligand 8	Homo sapiens	128-141
19447154-7	2009	The agonist of P2Y(1) and P2Y(12) receptors, 2-methylthioADP, caused an inhibition of noradrenaline release that was not prevented by inhibition of phospholipase C or protein kinase C but was abolished by pertussis toxin.	Norepinephrine	86-99	purinergic receptor P2Y1	Rattus norvegicus	15-21
19502771-4	2009	Norepinephrine and cortisol significantly increased (p<0.01) at HA1 and HA2 compared to SL1, while epinephrine did not change.	Norepinephrine	0-14	Rho GTPase activating protein 45	Homo sapiens	67-70
19502771-4	2009	Norepinephrine and cortisol significantly increased (p<0.01) at HA1 and HA2 compared to SL1, while epinephrine did not change.	Norepinephrine	0-14	keratin 32	Homo sapiens	75-78
19502771-8	2009	Moreover, norepinephrine levels were inversely correlated (r=-0.591; p<0.001) with IFN-gamma expression, a typical Th1 cytokine.	Norepinephrine	10-24	interferon gamma	Homo sapiens	86-95
19447154-8	2009	2-methylthioADP and the adenosine A(1) receptor agonist N(6)-cyclopentyladenosine were less potent at inhibiting noradrenaline release under marked influence of alpha(2)-autoinhibition.	Norepinephrine	113-126	adenosine A1 receptor	Rattus norvegicus	24-47
19447154-9	2009	In both tissues, nucleotides modulate noradrenaline release by activation of inhibitory P2Y(1) receptors but in the epididymal portion P2Y(12) receptors also participate.	Norepinephrine	38-51	purinergic receptor P2Y1	Rattus norvegicus	88-94
19447154-10	2009	P2Y(1) and P2Y(12) receptors are coupled to G(i/o)-proteins and operate as autoreceptors in the vas deferens where they interact with alpha(2)-adrenoceptors on the modulation of noradrenaline release.	Norepinephrine	178-191	purinergic receptor P2Y1	Rattus norvegicus	0-6
19829312-3	2009	Their study demonstrates a calcium-independent enhanced contractile response to angiotensin II following norepinephrine administration.	Norepinephrine	105-119	angiotensinogen	Homo sapiens	80-94
19740668-2	2009	Balanced serotonin/norepinephrine reuptake inhibitors (SNRIs) (i.e., (R)- and (S)-norduloxetine) were chemically linked to a PDE4 inhibitor via a five carbon bridge.	Norepinephrine	19-33	phosphodiesterase 4A	Homo sapiens	125-129
19396395-1	2009	Tyrosine hydroxylase (TH) catalyzes the conversion of L: -tyrosine to L: -dopa, which is the initial and rate-limiting step in the biosynthesis of catecholamines [CA; dopamine (DA), noradrenaline, and adrenaline], and plays a central role in the neurotransmission and hormonal actions of CA.	Norepinephrine	182-195	tyrosine hydroxylase	Homo sapiens	0-20
19396395-1	2009	Tyrosine hydroxylase (TH) catalyzes the conversion of L: -tyrosine to L: -dopa, which is the initial and rate-limiting step in the biosynthesis of catecholamines [CA; dopamine (DA), noradrenaline, and adrenaline], and plays a central role in the neurotransmission and hormonal actions of CA.	Norepinephrine	182-195	tyrosine hydroxylase	Homo sapiens	22-24
20081258-0	2009	Effect of peptide and nonpeptide antagonists of angiotensin II receptors on noradrenaline release in hypothalamus of rats with angiotensin II-induced increase of water intake.	Norepinephrine	76-89	angiotensinogen	Rattus norvegicus	48-62
20081258-0	2009	Effect of peptide and nonpeptide antagonists of angiotensin II receptors on noradrenaline release in hypothalamus of rats with angiotensin II-induced increase of water intake.	Norepinephrine	76-89	angiotensinogen	Rattus norvegicus	127-141
19740668-3	2009	The new dual SNRI/PDE4 inhibitors (i.e., (R)-15 and (S)-15) showed moderately potent serotonin reuptake inhibition (IC(50) values of 442 and 404 nM, respectively) but low reuptake inhibition of norepinephrine (IC(50) values of 2097 and 2190 nM, respectively) in vitro.	Norepinephrine	194-208	phosphodiesterase 4A	Homo sapiens	18-22
19545608-0	2009	The modulatory effect of substance P on rat pineal norepinephrine release and melatonin secretion.	Norepinephrine	51-65	tachykinin precursor 1	Homo sapiens	25-36
19094067-10	2009	GLP-1 infusion increased norepinephrine and cortisol levels during OGTT.	Norepinephrine	25-39	glucagon	Homo sapiens	0-5
19703475-11	2009	SIGNIFICANCE: The present results indicate that training can increase norepinephrine response of vas deferens in intact rats, while nandrolone decanoate can partially restore the responsiveness to norepinephrine in castrated rats.	Norepinephrine	70-84	arginine vasopressin	Rattus norvegicus	97-100
19500686-0	2009	Norepinephrine-dependently released Dr fimbriae of diffusely adhering Escherichia coli strain IH11128 promotes a mitogen-activated protein kinase ERK1/2-dependent production of pro-inflammatory cytokine, IL-8 in human intestinal Caco-2/TC7 cells.	Norepinephrine	0-14	mitogen-activated protein kinase 3	Homo sapiens	146-152
19703475-0	2009	Effects of swimming and nandrolone decanoate treatment on vas deferens response to norepinephrine.	Norepinephrine	83-97	arginine vasopressin	Rattus norvegicus	58-61
19703475-1	2009	AIMS: To investigate the response to norepinephrine of vas deferens isolated from intact and castrated rats submitted to swimming and/or treated with nandrolone decanoate.	Norepinephrine	37-51	arginine vasopressin	Rattus norvegicus	55-58
19703475-4	2009	Vas deferens was isolated and set up for analysis of its contractile capacity in response to norepinephrine.	Norepinephrine	93-107	arginine vasopressin	Rattus norvegicus	0-3
19703475-9	2009	An increased sensitivity (P<0.05) to norepinephrine was observed in vas deferens isolated from intact trained rats, treated or not with nandrolone decanoate, while nandrolone did not alter norepinephrine response in organs from untrained animals.	Norepinephrine	40-54	arginine vasopressin	Rattus norvegicus	71-74
19632110-2	2009	Synthesis of the two diastereomeric isomers of the molecule followed by chiral resolution of each enantiomer revealed the (2R,3S)-isomer to be a potent norepinephrine reuptake inhibitor (IC(50)=28 nM) with excellent selectivity over the dopamine transporter and 13-fold selectivity over the serotonin transporter.	Norepinephrine	152-166	solute carrier family 6 member 4	Homo sapiens	291-312
19573018-7	2009	Transfection of shRNAs specific to Phox2a or Phox2b genes significantly reduced mRNA and protein levels of NET and DBH after shutdown of endogenous Phox2, which was accompanied by a decreased [(3)H]norepinephrine uptake.	Norepinephrine	198-212	solute carrier family 6 member 2	Homo sapiens	107-110
19500686-0	2009	Norepinephrine-dependently released Dr fimbriae of diffusely adhering Escherichia coli strain IH11128 promotes a mitogen-activated protein kinase ERK1/2-dependent production of pro-inflammatory cytokine, IL-8 in human intestinal Caco-2/TC7 cells.	Norepinephrine	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	204-208
19564048-1	2009	The norepinephrine transporter (NET), which is involved in the neurotransmission of norepinephrine (NE), may play an important role in the development of major depressive disorder (MDD).	Norepinephrine	4-18	solute carrier family 6 member 2	Homo sapiens	32-35
19690620-1	2009	BACKGROUND: Candidate genes of psychological importance include 5HT2A, 5HT2C, and COMT, implicated in the serotonin, noradrenaline and dopamine pathways, which also may be involved in regulation of energy balance.	Norepinephrine	117-130	5-hydroxytryptamine receptor 2A	Homo sapiens	64-69
19468717-2	2009	We aimed to determine the potential correlations of 5-HTT/NET gene polymorphisms with the susceptibility to depression and the antidepressant response to selective serotonin reuptake inhibitors (SSRIs) or dual selective serotonin/norepinephrine reuptake inhibitors (SNRIs).	Norepinephrine	230-244	solute carrier family 6 member 2	Homo sapiens	58-61
19439521-4	2009	We tested the hypothesis that a Ca(2+) signaling pathway involving NAADP receptors participates in afferent arteriolar [Ca(2+)](i) responses to the G protein-coupled receptor agonists endothelin-1 (ET-1) and norepinephrine (NE).	Norepinephrine	208-222	endothelin 1	Rattus norvegicus	198-202
19457070-4	2009	TNF-alpha shed in response to PrP(C) acts as a second message signal, eliciting serotonin (5-HT) or norepinephrine (NE) degradation in 1C11(5-HT) or 1C11(NE) cells, respectively.	Norepinephrine	100-114	tumor necrosis factor	Mus musculus	0-9
18958498-3	2009	Because cyclic adenosine 3",5"-monophosphate stimulates the dopamine beta hydroxylase gene, an activating mutation of the Gsalpha protein may cause the hyperproduction of norepinephrine via dopamine.	Norepinephrine	171-185	GNAS complex locus	Homo sapiens	122-129
19573913-0	2009	Norepinephrine regulates arginine vasopressin secretion in hypothalamic paraventricular nucleus relating with pain modulation.	Norepinephrine	0-14	arginine vasopressin	Rattus norvegicus	34-45
19487588-10	2009	GRK2 mRNA expression directly correlated with systolic blood pressure and norepinephrine levels.	Norepinephrine	74-88	G protein-coupled receptor kinase 2	Homo sapiens	0-4
19246475-5	2009	ANG II infusion resulted in increased mean arterial pressure, renal sympathetic nerve activity, plasma proinflammatory cytokines (PIC), norepinephrine, and aldosterone.	Norepinephrine	136-150	angiotensinogen	Rattus norvegicus	0-6
19286648-4	2009	Although serum levels of leptin, IGF-1, and noradrenaline were altered in Sox8-deficient mice, these changes could not explain the observed phenotype.	Norepinephrine	44-57	SRY (sex determining region Y)-box 8	Mus musculus	74-78
19545450-1	2009	BACKGROUND: Reuptake of synaptic norepinephrine (NE) via the antidepressant-sensitive NE transporter (NET) supports efficient noradrenergic signaling and presynaptic NE homeostasis.	Norepinephrine	33-47	solute carrier family 6 member 2	Homo sapiens	86-100
19545450-1	2009	BACKGROUND: Reuptake of synaptic norepinephrine (NE) via the antidepressant-sensitive NE transporter (NET) supports efficient noradrenergic signaling and presynaptic NE homeostasis.	Norepinephrine	33-47	solute carrier family 6 member 2	Homo sapiens	102-105
19046481-9	2009	In contrast, in vitro exposure of cultured glial cells to noradrenaline suppressed IL-1beta, TNF-alpha, iNOS and CD40 expression.	Norepinephrine	58-71	interleukin 1 beta	Rattus norvegicus	83-91
19351633-8	2009	A relationship was found between baseline apelin and norepinephrine (r = 0.26, P = 0.008).	Norepinephrine	53-67	apelin	Homo sapiens	42-48
19384212-7	2009	The mean (sd) norepinephrine dose increased from 0.18 (0.18) microg x kg(-1) x min(-1) at 60 mm Hg to 0.41 (0.26) microg x kg(-1) x min(-1) at 90 mm Hg (p < 0.0001).	Norepinephrine	14-28	CD59 molecule (CD59 blood group)	Homo sapiens	79-85
19384212-7	2009	The mean (sd) norepinephrine dose increased from 0.18 (0.18) microg x kg(-1) x min(-1) at 60 mm Hg to 0.41 (0.26) microg x kg(-1) x min(-1) at 90 mm Hg (p < 0.0001).	Norepinephrine	14-28	CD59 molecule (CD59 blood group)	Homo sapiens	132-138
19715517-11	2009	Significantly greater up-regulation of CXC motif chemokine ligand and interleukin-1beta occurred in the livers of rats that received norepinephrine and vasopressin than in those that received no resuscitation.	Norepinephrine	133-147	interleukin 1 beta	Rattus norvegicus	70-87
19046481-9	2009	In contrast, in vitro exposure of cultured glial cells to noradrenaline suppressed IL-1beta, TNF-alpha, iNOS and CD40 expression.	Norepinephrine	58-71	tumor necrosis factor	Rattus norvegicus	93-102
19046481-9	2009	In contrast, in vitro exposure of cultured glial cells to noradrenaline suppressed IL-1beta, TNF-alpha, iNOS and CD40 expression.	Norepinephrine	58-71	nitric oxide synthase 2	Rattus norvegicus	104-108
19403604-6	2009	Total body noradrenaline spillover was 605.8 ng min(-1) +/- 34.4 ng min(-1).	Norepinephrine	11-24	CD59 molecule (CD59 blood group)	Homo sapiens	48-54
19403604-6	2009	Total body noradrenaline spillover was 605.8 ng min(-1) +/- 34.4 ng min(-1).	Norepinephrine	11-24	CD59 molecule (CD59 blood group)	Homo sapiens	68-74
19179649-5	2009	At 3 mo, alpha(2A)/alpha(2C)ARKO mice showed no signs of HF and preserved exercise tolerance and muscular norepinephrine with no changes in soleus morphology.	Norepinephrine	106-120	adrenergic receptor, alpha 2a	Mus musculus	9-17
19430461-8	2009	Conversely, when the only nonconserved HBP residue in both norepinephrine and dopamine transporters is mutated into that found in SERT, their affinities for all the three SSRIs increase uniformly.	Norepinephrine	59-73	solute carrier family 6 member 4	Homo sapiens	130-134
19237252-5	2009	We believe that the commonality between the CRPS, HF and PTSD is the trigger of increased nerve growth factor (NGF) leading to the increase in brain norepinephrine (NR), which in turn is affected by the SGB leading to a prolonged reduction of NGF and eventually a decrease in NR.	Norepinephrine	149-163	nerve growth factor	Homo sapiens	90-109
19237252-5	2009	We believe that the commonality between the CRPS, HF and PTSD is the trigger of increased nerve growth factor (NGF) leading to the increase in brain norepinephrine (NR), which in turn is affected by the SGB leading to a prolonged reduction of NGF and eventually a decrease in NR.	Norepinephrine	149-163	nerve growth factor	Homo sapiens	111-114
19237252-5	2009	We believe that the commonality between the CRPS, HF and PTSD is the trigger of increased nerve growth factor (NGF) leading to the increase in brain norepinephrine (NR), which in turn is affected by the SGB leading to a prolonged reduction of NGF and eventually a decrease in NR.	Norepinephrine	149-163	nerve growth factor	Homo sapiens	243-246
19458216-4	2009	In late pregnancy, HPA axis responses to stressors, including IL-1beta, are attenuated by a central opioid mechanism that auto-inhibits noradrenaline release in the PVN.	Norepinephrine	136-149	interleukin 1 beta	Rattus norvegicus	62-70
19239407-9	2009	CONCLUSIONS: Infusion of low to moderate doses of vasopressin in patients with norepinephrine-dependent vasodilatory shock after cardiac surgery induces an intestinal and gastric mucosal vasoconstriction.	Norepinephrine	79-93	arginine vasopressin	Homo sapiens	50-61
19179649-7	2009	At 7 mo, alpha(2A)/alpha(2C)ARKO mice displayed exercise intolerance and increased muscular norepinephrine, muscular atrophy, capillary rarefaction, and increased oxidative stress.	Norepinephrine	92-106	adrenergic receptor, alpha 2a	Mus musculus	9-17
19223317-7	2009	Cardiac norepinephrine increased seven-fold, possibly due to the rise in angiotensin II.	Norepinephrine	8-22	angiotensinogen	Homo sapiens	73-87
19309436-4	2009	We observed that IL-1beta increases the release of NPY, norepinephrine (NE), and epinephrine (EP) from human chromaffin cells.	Norepinephrine	56-70	interleukin 1 beta	Homo sapiens	17-25
19251826-5	2009	We were surprised to find that only a few functions previously ascribed to alpha(2)-adrenoceptors were mediated by receptors on adrenergic neurons, including feedback inhibition of norepinephrine release from sympathetic nerves and spontaneous locomotor activity.	Norepinephrine	181-195	adrenergic receptor, alpha 2a	Mus musculus	75-97
18850267-3	2009	In the present work we studied the effect of endothelin-1 and -3 on neuronal norepinephrine release and the short-term regulation of tyrosine hydroxylase in the olfactory bulb.	Norepinephrine	77-91	endothelin 1	Rattus norvegicus	45-64
19299782-0	2009	The effects of benzodiazepines on urotensin II-stimulated norepinephrine release from rat cerebrocortical slices.	Norepinephrine	58-72	urotensin 2	Rattus norvegicus	34-46
19299782-1	2009	BACKGROUND: Urotensin II (UII) and its receptor (UT) are implicated in mood disorders, such as stress and anxiety, and this may result, at least in part, from increased norepinephrine release from the cerebral cortex.	Norepinephrine	169-183	urotensin 2	Rattus norvegicus	12-24
19299782-1	2009	BACKGROUND: Urotensin II (UII) and its receptor (UT) are implicated in mood disorders, such as stress and anxiety, and this may result, at least in part, from increased norepinephrine release from the cerebral cortex.	Norepinephrine	169-183	urotensin 2	Rattus norvegicus	26-29
19299782-4	2009	METHODS: In the present study, we have examined the effects of benzodiazepines on UII-increased norepinephrine release from rat cerebrocortical slices and intracellular Ca(2+) concentrations ([Ca(2+)]i) in HEK293 cells expressing rat UT receptor (HEK293-rUT cells).	Norepinephrine	96-110	urotensin 2	Rattus norvegicus	82-85
19299782-5	2009	RESULTS: Midazolam, diazepam and flunitrazepam concentration-dependently inhibited UII-evoked norepinephrine release but did not affect [Ca(2+)]i.	Norepinephrine	94-108	urotensin 2	Rattus norvegicus	83-86
19299782-6	2009	The IC(50) of midazolam for inhibition of UII-evoked norepinephrine release (0.32 microM, P < 0.01) was significantly lower than that of diazepam (187 microM) or flunitrazepam (40 microM).	Norepinephrine	53-67	urotensin 2	Rattus norvegicus	42-45
19299782-7	2009	The inhibitory effects of midazolam on UII-evoked norepinephrine release were significantly attenuated by flumazenil, a benzodiazepine site antagonist.	Norepinephrine	50-64	urotensin 2	Rattus norvegicus	39-42
19299782-8	2009	CONCLUSION: The present study suggests that midazolam, at clinically relevant concentration, significantly inhibited UII-evoked norepinephrine release.	Norepinephrine	128-142	urotensin 2	Rattus norvegicus	117-120
19036879-3	2009	In the present study, we have analyzed the role of GC-dependent signaling in the postnatal development of adrenal chromaffin cells by conditional inactivation of the GR gene in cells expressing dopamine-beta-hydroxylase, an enzyme required for the synthesis of noradrenaline and adrenaline.	Norepinephrine	261-274	dopamine beta hydroxylase	Mus musculus	194-219
19429033-3	2009	Combined depletion of both serotonin and norepinephrine with para-chlorophenylalanine (PCPA) resulted in a significant decrease in Smo and Ptc mRNA within the dentate gyrus subfield of the hippocampus.	Norepinephrine	41-55	smoothened, frizzled class receptor	Rattus norvegicus	131-134
19691565-9	2009	CONCLUSION: Vasopressin (0.01-0.04 U/min, IV) should be considered in small animal veterinary patients with vasodilatory shock that is unresponsive to fluid resuscitation and catecholamine (dobutamine, dopamine, and norepinephrine) administration.	Norepinephrine	216-230	arginine vasopressin	Homo sapiens	12-23
19338744-1	2009	The serotonin transporter is a member of the monoamine transporter family that also includes transporters of dopamine and norepinephrine.	Norepinephrine	122-136	solute carrier family 6 member 4	Rattus norvegicus	4-25
19323834-1	2009	BACKGROUND: In astrocytes, the inflammatory induction of Nitric Oxide Synthase type 2 (NOS2) is inhibited by noradrenaline (NA) at the transcriptional level however its effects on specific transcription factors are not fully known.	Norepinephrine	109-122	nitric oxide synthase 2	Homo sapiens	57-85
19323834-1	2009	BACKGROUND: In astrocytes, the inflammatory induction of Nitric Oxide Synthase type 2 (NOS2) is inhibited by noradrenaline (NA) at the transcriptional level however its effects on specific transcription factors are not fully known.	Norepinephrine	109-122	nitric oxide synthase 2	Homo sapiens	87-91
19212675-2	2009	By microarray expression analysis (Affymetrix HU133A) important players in the noradrenalin biosynthesis pathway (DBH, DDC, GATA2, GATA3, PHOX2A, PHOX2B, SLC6A2 SLC18A1 and TH) were found to be among the top ranked genes in showing lower expression in unfavorable NB tumor types as compared to favorable ones.	Norepinephrine	79-91	dopa decarboxylase	Homo sapiens	119-122
19159673-6	2009	Consistent with a role for sympathetic nervous system (SNS) activation in stress-induced immune regulation, the sympathetic neurotransmitter noradrenaline increased LPS-induced IL-10 and IL-19 expression in splenocytes and dendritic cells, and the ability of noradrenaline to induce expression of these cytokines was blocked by pre-treatment with the beta-adrenoceptor antagonist propranolol.	Norepinephrine	141-154	interleukin 10	Mus musculus	177-182
19159673-6	2009	Consistent with a role for sympathetic nervous system (SNS) activation in stress-induced immune regulation, the sympathetic neurotransmitter noradrenaline increased LPS-induced IL-10 and IL-19 expression in splenocytes and dendritic cells, and the ability of noradrenaline to induce expression of these cytokines was blocked by pre-treatment with the beta-adrenoceptor antagonist propranolol.	Norepinephrine	141-154	interleukin 19	Mus musculus	187-192
19054775-1	2009	BACKGROUND: The cytokine, interleukin-1 beta (IL-1 beta), increases during immune stress and is known to suppress the preovulatory luteinizing hormone (LH) surge in female rats by decreasing hypothalamic norepinephrine (NE).	Norepinephrine	204-218	interleukin 1 beta	Rattus norvegicus	26-44
19054775-1	2009	BACKGROUND: The cytokine, interleukin-1 beta (IL-1 beta), increases during immune stress and is known to suppress the preovulatory luteinizing hormone (LH) surge in female rats by decreasing hypothalamic norepinephrine (NE).	Norepinephrine	204-218	interleukin 1 beta	Rattus norvegicus	46-55
19302815-2	2009	Previously, we reported that noradrenaline (NA) microinjection into the dPAG caused a pressor response that was mediated by vasopressin release into the circulation.	Norepinephrine	29-42	arginine vasopressin	Rattus norvegicus	124-135
19237882-1	2009	OBJECTIVE: Vasopressin and corticosteroids are often added to support cardiovascular dysfunction in patients who have septic shock that is nonresponsive to fluid resuscitation and norepinephrine infusion.	Norepinephrine	180-194	arginine vasopressin	Homo sapiens	11-22
19237882-16	2009	The combination of low-dose vasopressin and corticosteroids was associated with decreased mortality and organ dysfunction compared with norepinephrine and corticosteroids.	Norepinephrine	136-150	arginine vasopressin	Homo sapiens	28-39
19212675-2	2009	By microarray expression analysis (Affymetrix HU133A) important players in the noradrenalin biosynthesis pathway (DBH, DDC, GATA2, GATA3, PHOX2A, PHOX2B, SLC6A2 SLC18A1 and TH) were found to be among the top ranked genes in showing lower expression in unfavorable NB tumor types as compared to favorable ones.	Norepinephrine	79-91	solute carrier family 6 member 2	Homo sapiens	154-160
19439816-6	2009	Adrenalin, noradrenalin or dopamine also inhibited the iNOS protein expression and the nitrite accumulation.	Norepinephrine	11-23	nitric oxide synthase 2, inducible	Mus musculus	55-59
18952694-0	2009	Selective cyclooxygenase-2 inhibition directly increases human vascular reactivity to norepinephrine during acute inflammation.	Norepinephrine	86-100	prostaglandin-endoperoxide synthase 2	Homo sapiens	10-26
18923160-5	2009	Insulin in vitro increased the basal release of norepinephrine from the ovaries of control rats but not from those of stressed rats, suggesting a local neural resistance to insulin in stressed rats.	Norepinephrine	48-62	insulin	Homo sapiens	0-7
18996182-0	2009	Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: implications for stress-related enhancement of tumor progression.	Norepinephrine	0-14	vascular endothelial growth factor A	Homo sapiens	27-31
18996182-0	2009	Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: implications for stress-related enhancement of tumor progression.	Norepinephrine	0-14	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
18996182-0	2009	Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: implications for stress-related enhancement of tumor progression.	Norepinephrine	0-14	interleukin 6	Homo sapiens	43-47
18818287-9	2009	This suppression appears to be mediated by cAMP, a second messenger of norepinephrine in the pineal gland, based on the observation that treatment with a cAMP mimic reduces pineal Pax4 mRNA levels.	Norepinephrine	71-85	cathelicidin antimicrobial peptide	Homo sapiens	43-47
18818287-9	2009	This suppression appears to be mediated by cAMP, a second messenger of norepinephrine in the pineal gland, based on the observation that treatment with a cAMP mimic reduces pineal Pax4 mRNA levels.	Norepinephrine	71-85	cathelicidin antimicrobial peptide	Homo sapiens	154-158
19023134-8	2009	Finally, we demonstrate that 5-HT(2B) receptors are overexpressed in hearts from patients with congestive heart failure, this overexpression being positively correlated with cytokine and norepinephrine plasma levels.	Norepinephrine	187-201	5-hydroxytryptamine receptor 2B	Homo sapiens	29-36
19022248-9	2009	However, the response to noradrenaline was greater in the transplant than in the control vas deferens.	Norepinephrine	25-38	arginine vasopressin	Rattus norvegicus	89-92
18854975-1	2009	PURPOSE: To test the hypothesis whether genetic over-expression of the Cu/Zn-superoxide dismutase (SOD-1) prevents the sepsis-related impairment of myocardial function and norepinephrine responsiveness in a resuscitated murine model of septic shock.	Norepinephrine	172-186	superoxide dismutase 1, soluble	Mus musculus	99-104
18984669-9	2009	Insulin-stimulated peripheral glucose uptake was higher in both clamps after LPS compared to the control setting (P = 0.006 and 0.010), despite a significant increase in the plasma concentrations of norepinephrine and cytokines in the LPS group during both clamps.	Norepinephrine	199-213	insulin	Homo sapiens	0-7
18835437-7	2009	In the vaccine/stress group, participants with larger IL-6 responses had heightened systolic blood pressure responses to tasks and elevated post-stress salivary levels of the noradrenaline metabolite 3-methoxy-phenyl glycol (MHPG) and cortisol.	Norepinephrine	175-188	interleukin 6	Homo sapiens	54-58
19234363-1	2009	Endothelin-1 (ET-1) modulates cardiac contractility by cross-talk with norepinephrine (NE) in canine ventricular myocardium.	Norepinephrine	71-85	endothelin 1	Canis lupus familiaris	0-12
19038969-6	2009	Combined activation of insulin-like growth factor 1 and epidermal growth factor receptors was particularly notable for antagonistic interactions at some levels of signal transduction and norepinephrine production, but potentiation at other levels of signaling and cytoprotection.	Norepinephrine	187-201	insulin like growth factor 1	Homo sapiens	23-51
19471100-0	2009	Crucial role of interleukin-6 in the development of norepinephrine-induced left ventricular remodeling in mice.	Norepinephrine	52-66	interleukin 6	Mus musculus	16-29
19753521-0	2009	Correlation between CD34+ and exercise capacity, functional class, quality of life and norepinephrine in heart failure patients.	Norepinephrine	87-101	CD34 molecule	Homo sapiens	20-24
19753521-2	2009	The aim of this study was to correlate CD34(+) levels to exercise capacity, functional class, quality of life and norepinephrine in heart failure patients.	Norepinephrine	114-128	CD34 molecule	Homo sapiens	39-43
19014915-0	2009	Interaction between GABA and norepinephrine in interleukin-1beta-induced suppression of the luteinizing hormone surge.	Norepinephrine	29-43	interleukin 1 beta	Rattus norvegicus	47-64
19664253-3	2009	The aim of the present prospective, randomized, controlled pilot trial study was, therefore, to compare the impact of continuous infusions of either vasopressin or terlipressin, when given as first-line therapy in septic shock patients, on open-label norepinephrine requirements.	Norepinephrine	251-265	arginine vasopressin	Homo sapiens	149-160
19302552-3	2009	It was observed that at nanomolar concentrations the MEK inhibitors, PD98059 (2"-amino-3"-methoxyflavone) and UO126 [1,4-(diamino-2,3-dicyano/1,4-bis-(2-aminophenylthio)-butadiene], increased alpha(1B)-adrenoceptor phosphorylation and diminished the functional response of this receptor to noradrenaline.	Norepinephrine	290-303	mitogen-activated protein kinase kinase 7	Homo sapiens	53-56
18986337-6	2009	Angiotensin II (10-300 nmol) induced vasodilation in noradrenaline (NA)-preconstricted MAB that was greater in vessels from young compared with adult rats in both the control and SHR groups.	Norepinephrine	53-66	angiotensinogen	Rattus norvegicus	0-14
18805863-2	2009	Contraction, overflow and electrophysiology experiments all show that both ATP and noradrenaline are released following field stimulation (although the ratio might vary) from autonomic nerves in tissues including the vas deferens, rat tail artery and mesenteric artery.	Norepinephrine	83-96	arginine vasopressin	Rattus norvegicus	217-220
19439970-5	2009	RESULTS: A significant correlation between norepinephrine support and IL-6 plasma concentrations was shown at the separation from CPB (k = 0.742) and 12 h after it (k = 0.801) as well as between norepinephrine support and IL-8 concentrations 12 h after the separation from CPB.	Norepinephrine	43-57	interleukin 6	Homo sapiens	70-74
19439970-5	2009	RESULTS: A significant correlation between norepinephrine support and IL-6 plasma concentrations was shown at the separation from CPB (k = 0.742) and 12 h after it (k = 0.801) as well as between norepinephrine support and IL-8 concentrations 12 h after the separation from CPB.	Norepinephrine	43-57	C-X-C motif chemokine ligand 8	Homo sapiens	222-226
19120100-2	2008	Acute peripheral LPS administration activated norepinephrine (NE) metabolism in the locus ceruleus (LC).	Norepinephrine	46-60	toll-like receptor 4	Mus musculus	17-20
19212441-1	2009	Following our recent report that phagocytic cells (neutrophils, PMNs, and macrophages) are newly discovered sources of catecholamines, we now show that both epinephrine and norepinephrine directly activate NFkappaB in macrophages, causing enhanced release of proinflammatory cytokines (TNFalpha, IL-1beta, IL-6).	Norepinephrine	173-187	tumor necrosis factor	Rattus norvegicus	286-294
19212441-1	2009	Following our recent report that phagocytic cells (neutrophils, PMNs, and macrophages) are newly discovered sources of catecholamines, we now show that both epinephrine and norepinephrine directly activate NFkappaB in macrophages, causing enhanced release of proinflammatory cytokines (TNFalpha, IL-1beta, IL-6).	Norepinephrine	173-187	interleukin 1 beta	Rattus norvegicus	296-304
19212441-1	2009	Following our recent report that phagocytic cells (neutrophils, PMNs, and macrophages) are newly discovered sources of catecholamines, we now show that both epinephrine and norepinephrine directly activate NFkappaB in macrophages, causing enhanced release of proinflammatory cytokines (TNFalpha, IL-1beta, IL-6).	Norepinephrine	173-187	interleukin 6	Rattus norvegicus	306-310
19022290-1	2009	Biogenic amine transporters for serotonin, norepinephrine and dopamine (SERT, NET and DAT respectively), are the key players terminating transmission of these amines in the central nervous system by their high-affinity uptake.	Norepinephrine	43-57	solute carrier family 6 member 4	Homo sapiens	72-76
19120127-13	2008	We have demonstrated that the reduced neuronal noradrenaline reuptake present in both disorders does have an epigenetic mechanism, with demonstrable reduction in the abundance of the transporter protein, the NET gene silencing being associated with DNA binding by the methylation-related inhibitory transcription factor MeCP2.	Norepinephrine	47-60	solute carrier family 6 member 2	Homo sapiens	208-211
19120118-1	2008	Norepinephrine-deficient mice harbor a disruption of the gene for dopamine-beta-hydroxylase (DBH-KO).	Norepinephrine	0-14	dopamine beta hydroxylase	Mus musculus	66-91
19120127-13	2008	We have demonstrated that the reduced neuronal noradrenaline reuptake present in both disorders does have an epigenetic mechanism, with demonstrable reduction in the abundance of the transporter protein, the NET gene silencing being associated with DNA binding by the methylation-related inhibitory transcription factor MeCP2.	Norepinephrine	47-60	methyl-CpG binding protein 2	Homo sapiens	320-325
19120138-5	2008	HPA axis responses to IL-1beta and CCK can be reinstated in pregnant rats by systemic administration of the opioid receptor antagonist naloxone, and when infused directly into the PVN, naloxone restores noradrenaline release in the PVN following IL-1beta treatment.	Norepinephrine	203-216	interleukin 1 beta	Rattus norvegicus	22-30
19120138-3	2008	Forced swimming, systemic interleukin-1beta (IL-1beta), and cholecystokinin (CCK) all activate brain stem noradrenergic cell groups, stimulate noradrenaline release in the PVN, and activate the HPA axis in nonpregnant rats.	Norepinephrine	143-156	interleukin 1 beta	Rattus norvegicus	26-43
19120138-3	2008	Forced swimming, systemic interleukin-1beta (IL-1beta), and cholecystokinin (CCK) all activate brain stem noradrenergic cell groups, stimulate noradrenaline release in the PVN, and activate the HPA axis in nonpregnant rats.	Norepinephrine	143-156	interleukin 1 beta	Rattus norvegicus	45-53
19120118-1	2008	Norepinephrine-deficient mice harbor a disruption of the gene for dopamine-beta-hydroxylase (DBH-KO).	Norepinephrine	0-14	dopamine beta hydroxylase	Mus musculus	93-96
18682267-1	2008	We previously reported that endothelin-1 and endothelin-3 modulate norepinephrine neuronal release and tyrosine hydroxylase activity and expression in the hypothalamus.	Norepinephrine	67-81	endothelin 1	Rattus norvegicus	28-40
18682267-2	2008	In the present study we sought to establish the role of endothelin-1 and -3 in the regulation of norepinephrine uptake in the anterior and posterior hypothalamus.	Norepinephrine	97-111	endothelin 1	Rattus norvegicus	56-75
18682267-12	2008	Present results permit us to conclude that both endothelins play an important role in the regulation of norepinephrine neurotransmission at the presynaptic nerve endings in the hypothalamus.	Norepinephrine	104-118	endothelin 1	Rattus norvegicus	48-59
18835922-9	2008	In contrast, ANG II greatly enhanced norepinephrine overflow in the presence of PD-123319.	Norepinephrine	37-51	angiotensinogen	Rattus norvegicus	13-19
19090328-11	2008	After we adjusted for adiposity, adiponectin levels remained negatively correlated with AHI (P = 0.037), arousal index (P = 0.022), HOMA-IR/fasting insulin (P < 0.001), and urinary norepinephrine and normetanephrine (P < 0.008).	Norepinephrine	184-198	adiponectin, C1Q and collagen domain containing	Homo sapiens	33-44
19090328-12	2008	In a multiple stepwise regression model, the independent determinants of adiponectin after adjustment for adiposity were HOMA-IR (P < 0.001) and urinary norepinephrine and normetanephrine (P = 0.037).	Norepinephrine	156-170	adiponectin, C1Q and collagen domain containing	Homo sapiens	73-84
18815045-1	2008	Norepinephrine transporter (NET) and serotonin transporter (SERT) proteins regulate norepinephrine (NE) and serotonin via their reuptake function and are targets of antidepressants action.	Norepinephrine	84-98	solute carrier family 6 member 4	Homo sapiens	37-58
18975332-10	2008	In addition, splenic IFNgamma secretion was stimulated by norepinephrine, via beta-adrenergic receptors, and adenosine, via A1 adenosine receptors.	Norepinephrine	58-72	interferon gamma	Mus musculus	21-29
18815045-1	2008	Norepinephrine transporter (NET) and serotonin transporter (SERT) proteins regulate norepinephrine (NE) and serotonin via their reuptake function and are targets of antidepressants action.	Norepinephrine	84-98	solute carrier family 6 member 4	Homo sapiens	60-64
19067837-7	2008	Expression of TLR-9 and TLR-11 in cells exposed to norepinephrine (NE) and parasites was significantly decreased when compared to cells exposed to parasites only.	Norepinephrine	51-65	toll-like receptor 11	Mus musculus	24-30
18644394-4	2008	Contractile responses mediated by 5-HT(1B) receptors may be increased in blood vessels with damaged endothelium, but may also be augmented in the presence of low concentrations of other vasoconstrictors such as thromboxane A(2), endothelin-1, prostaglandin F(2alpha), angiotensin II, histamine, noradrenaline, phenylephrine or KCl.	Norepinephrine	295-308	5-hydroxytryptamine receptor 1B	Homo sapiens	34-41
18317403-2	2008	Therefore, we tested the hypothesis that genetic overexpression of the Cu/Zn-superoxide dismutase (SOD-1) may restore the sepsis-related lack of the norepinephrine-induced increase in hepatic gluconeogenesis and whole-body glucose oxidation.	Norepinephrine	149-163	superoxide dismutase 1, soluble	Mus musculus	99-104
18625224-5	2008	DSP-4 treatment reduced hippocampal noradrenaline (NA) by more than 90% (vs. controls), whereas dopamine and 5-HT levels were unaffected.	Norepinephrine	36-49	dual specificity phosphatase 26	Homo sapiens	0-5
18821705-8	2008	The positive correlation between hypothalamic IL-1beta expression and noradrenaline content in control groups was not observed in rats in which arthritis developed.	Norepinephrine	70-83	interleukin 1 beta	Rattus norvegicus	46-54
19489307-4	2008	Brain norepinephrine had an inhibitory effect on proliferative activity and differentiation of erythroid precursors that were associated with the erythropoietin and peripheral alpha-adrenergic structures.	Norepinephrine	6-20	erythropoietin	Homo sapiens	146-160
18552869-8	2008	Increasing concentrations of exogenously administered noradrenaline (10 nM-1 mM) produced mean concentration-response curves in prostates from alpha1A +/+ and alpha1A +/- mice, which were not different.	Norepinephrine	54-67	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	143-150
19001767-4	2008	The content of uncoupling protein 1 (UCP1) in IBAT and urinary noradrenaline and adrenaline excretions were significantly higher in rats fed the 0.1 or 0.2% oleuropein diet, as compared with those of rats fed with the control diet, although there were no significant differences in rats fed the 0.4% oleuropein diet.	Norepinephrine	63-76	uncoupling protein 1	Rattus norvegicus	15-35
19001767-4	2008	The content of uncoupling protein 1 (UCP1) in IBAT and urinary noradrenaline and adrenaline excretions were significantly higher in rats fed the 0.1 or 0.2% oleuropein diet, as compared with those of rats fed with the control diet, although there were no significant differences in rats fed the 0.4% oleuropein diet.	Norepinephrine	63-76	uncoupling protein 1	Rattus norvegicus	37-41
18586023-11	2008	These findings indicate that cardiac endothelin-1 production is enhanced by ischemia/reperfusion, and this endogenously increased endothelin-1 is involved in post-ischemic norepinephrine overflow and cardiac dysfunction via the activation of endothelin ET(A) receptors.	Norepinephrine	172-186	endothelin 1	Rattus norvegicus	37-49
18586023-11	2008	These findings indicate that cardiac endothelin-1 production is enhanced by ischemia/reperfusion, and this endogenously increased endothelin-1 is involved in post-ischemic norepinephrine overflow and cardiac dysfunction via the activation of endothelin ET(A) receptors.	Norepinephrine	172-186	endothelin 1	Rattus norvegicus	130-142
18781914-4	2008	The pro-inflammatory cytokine interferon-gamma stimulates the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4), which is cofactor for several aromatic amino acid monooxygenases and thus is strongly involved in the biosynthesis of the neurotransmitter serotonin and the catecholamines dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline).	Norepinephrine	324-338	interferon gamma	Homo sapiens	30-46
18781914-4	2008	The pro-inflammatory cytokine interferon-gamma stimulates the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4), which is cofactor for several aromatic amino acid monooxygenases and thus is strongly involved in the biosynthesis of the neurotransmitter serotonin and the catecholamines dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline).	Norepinephrine	340-353	interferon gamma	Homo sapiens	30-46
18775326-2	2008	In lymphoid organs, the neurotransmitter norepinephrine stimulates beta(2)-adrenergic receptors on B lymphocytes to promote CREB-dependent expression of genes like the B cell Oct 2 coactivator (OCA-B).	Norepinephrine	41-55	cAMP responsive element binding protein 1	Mus musculus	124-128
18687199-4	2008	However, patients with less severe septic shock (ie, < 15 microg/min of norepinephrine) at arginine vasopressin initiation had a lower 28-day mortality rate compared with norepinephrine-only infusion (26.5% vs 35.7%; P = 0.05).	Norepinephrine	75-89	arginine vasopressin	Homo sapiens	103-114
18552869-8	2008	Increasing concentrations of exogenously administered noradrenaline (10 nM-1 mM) produced mean concentration-response curves in prostates from alpha1A +/+ and alpha1A +/- mice, which were not different.	Norepinephrine	54-67	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	159-166
18552869-9	2008	Maximum responses to noradrenaline were decreased by approximately 80% in prostates from alpha1A -/- mice compared with alpha1A +/+ mice.	Norepinephrine	21-34	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	89-96
18552869-9	2008	Maximum responses to noradrenaline were decreased by approximately 80% in prostates from alpha1A -/- mice compared with alpha1A +/+ mice.	Norepinephrine	21-34	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	120-127
18572318-3	2008	To test this hypothesis, we have examined the effects of UII on norepinephrine release from rat cerebrocortical slices.	Norepinephrine	64-78	urotensin 2	Rattus norvegicus	57-60
18598693-13	2008	These results suggest that the brain neuronal NOS/COX-1 and inducible NOS/COX-1 are respectively involved in the bombesin-induced secretion of noradrenaline and adrenaline from the adrenal medulla in rats.	Norepinephrine	143-156	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	50-55
18598693-13	2008	These results suggest that the brain neuronal NOS/COX-1 and inducible NOS/COX-1 are respectively involved in the bombesin-induced secretion of noradrenaline and adrenaline from the adrenal medulla in rats.	Norepinephrine	143-156	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	74-79
18665439-4	2008	An inverse relationship exists between liver tryptophan-2,3-dioxygenase activity and brain serotonin levels and there is an interdependency between serotonin and norepinephrine levels.	Norepinephrine	162-176	tryptophan 2,3-dioxygenase	Rattus norvegicus	45-71
18572318-7	2008	UII produced a time- (peaking at approximately 10 min following stimulation with 10nM) and concentration-dependent increase in norepinephrine release with pEC(50) and E(max) (% of basal) values of 8.78+/-0.17 (1.65 nM) and 138+/-2%, respectively.	Norepinephrine	127-141	urotensin 2	Rattus norvegicus	0-3
18572318-11	2008	The UT antagonist UFP-803 reversed both UII-increased norepinephrine release from the cerebrocortical slices (pK(B)=8.98) and [Ca(2+)](i) (pK(B)=8.87) in HEK293-rUT cells.	Norepinephrine	54-68	urotensin 2	Rattus norvegicus	40-43
18572318-12	2008	Collectively these data suggest that UII evokes the release of norepinephrine via UT receptor activation and produces similar effects on other wakefulness-promoting neurotransmitters: these neurochemical actions of UII may be important for the control of the sleep-wake cycle.	Norepinephrine	63-77	urotensin 2	Rattus norvegicus	37-40
18572318-12	2008	Collectively these data suggest that UII evokes the release of norepinephrine via UT receptor activation and produces similar effects on other wakefulness-promoting neurotransmitters: these neurochemical actions of UII may be important for the control of the sleep-wake cycle.	Norepinephrine	63-77	urotensin 2	Rattus norvegicus	215-218
18636164-0	2008	Stress-associated hormone, norepinephrine, increases proliferation and IL-6 levels of human pancreatic duct epithelial cells and can be inhibited by the dietary agent, sulforaphane.	Norepinephrine	27-41	interleukin 6	Homo sapiens	71-75
18670361-1	2008	We investigated whether endogenous and exogenous angiotensin II (Ang II) regulates norepinephrine (NE) release from cardiac sympathetic nerves via both Ang II type 2 receptors (AT2Rs) and Ang II type 1 receptors (AT1Rs).	Norepinephrine	83-97	angiotensinogen	Rattus norvegicus	49-63
18670361-1	2008	We investigated whether endogenous and exogenous angiotensin II (Ang II) regulates norepinephrine (NE) release from cardiac sympathetic nerves via both Ang II type 2 receptors (AT2Rs) and Ang II type 1 receptors (AT1Rs).	Norepinephrine	83-97	angiotensinogen	Rattus norvegicus	65-71
18621528-0	2008	Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modulation of H-bond acceptor capacity.	Norepinephrine	75-88	phosphoglycolate phosphatase	Rattus norvegicus	119-123
18513370-1	2008	Tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline and adrenaline, is regulated acutely by feedback inhibition by the catecholamines and relief of this inhibition by phosphorylation of serine 40 (Ser40).	Norepinephrine	104-117	tyrosine hydroxylase	Homo sapiens	0-20
18513370-1	2008	Tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline and adrenaline, is regulated acutely by feedback inhibition by the catecholamines and relief of this inhibition by phosphorylation of serine 40 (Ser40).	Norepinephrine	104-117	tyrosine hydroxylase	Homo sapiens	22-24
18777604-1	2008	Systemic administration of tumour necrosis factor (TNF)-alpha induces the release of norepinephrine in the paraventricular nucleus (PVN) of hypothalamus and an increase in expression of corticotrophin-releasing factor (CRF) and CRF type 1 receptors.	Norepinephrine	85-99	tumor necrosis factor	Rattus norvegicus	27-61
18777604-2	2008	We explored the hypothesis that CRF and norepinephrine in PVN mediate the cardiovascular and sympathetic responses to acute systemic administration of TNF-alpha.	Norepinephrine	40-54	tumor necrosis factor	Rattus norvegicus	151-160
18777604-7	2008	These results are consistent with the hypothesis that norepinephrine and CRF in the PVN mediate the cardiovascular and sympathetic responses to acute systemic administration of TNF-alpha.	Norepinephrine	54-68	tumor necrosis factor	Rattus norvegicus	177-186
18636164-6	2008	We also evaluated the ability of norepinephrine to induce interleukin-6 (IL-6), interleukin-10 (IL-10), and vascular endothelial growth factor (VEGF).	Norepinephrine	33-47	interleukin 6	Homo sapiens	58-71
18636164-6	2008	We also evaluated the ability of norepinephrine to induce interleukin-6 (IL-6), interleukin-10 (IL-10), and vascular endothelial growth factor (VEGF).	Norepinephrine	33-47	interleukin 6	Homo sapiens	73-77
18636164-6	2008	We also evaluated the ability of norepinephrine to induce interleukin-6 (IL-6), interleukin-10 (IL-10), and vascular endothelial growth factor (VEGF).	Norepinephrine	33-47	vascular endothelial growth factor A	Homo sapiens	108-142
18636164-6	2008	We also evaluated the ability of norepinephrine to induce interleukin-6 (IL-6), interleukin-10 (IL-10), and vascular endothelial growth factor (VEGF).	Norepinephrine	33-47	vascular endothelial growth factor A	Homo sapiens	144-148
18636164-8	2008	We found that norepinephrine can increase the IL-6 and VEGF but not IL-10 levels secreted by human pancreatic duct epithelial cells.	Norepinephrine	14-28	interleukin 6	Homo sapiens	46-50
18636164-8	2008	We found that norepinephrine can increase the IL-6 and VEGF but not IL-10 levels secreted by human pancreatic duct epithelial cells.	Norepinephrine	14-28	vascular endothelial growth factor A	Homo sapiens	55-59
18636164-11	2008	Furthermore, sulforaphane also inhibits norepinephrine-mediated increase of the IL-6 levels but not VEGF levels.	Norepinephrine	40-54	interleukin 6	Homo sapiens	80-84
18636164-12	2008	Our study is the first to demonstrate that stress-associated hormone, norepinephrine, can increase the cell proliferation and IL-6 levels of human pancreatic duct epithelial cells, which can be inhibited by sulforaphane, a chemopreventive agent and a natural compound from the Cruciferous vegetables.	Norepinephrine	70-84	interleukin 6	Homo sapiens	126-130
18514187-2	2008	During neuropathic pain development in the chronic constriction injury model, elevated TNF levels in the brain occur in association with enhanced alpha 2-adrenoceptor inhibition of norepinephrine release.	Norepinephrine	181-195	tumor necrosis factor	Rattus norvegicus	87-90
18491079-7	2008	Despite the diminution of the behavioral and neuroendocrine effects of the cytokine after treatment 7 days, subchronic IL-1beta infusion altered prefrontal cortical and hippocampal serotonin and norepinephrine utilization, and within these regions, the messenger RNA (mRNA) expression of IL-1beta, IL-6, TNF-alpha, and their receptors, as well as that of 5-HT(2C), 5-HT(1B) receptors, and p11, was increased.	Norepinephrine	195-209	interleukin 1 beta	Mus musculus	119-127
18445123-3	2008	The catecholaminergic afferents of CRH and TRH neurones originate from both noradrenaline- and adrenaline-synthesising cell groups located in the brainstem, and collectively represent one of the most well studied neural inputs of these neurones.	Norepinephrine	76-89	corticotropin releasing hormone	Rattus norvegicus	35-38
18552697-11	2008	Erythropoietin reduced the noradrenaline requirements to achieve the hemodynamic targets and may improve kidney function despite similar organ blood flow, histology, and TUNEL staining.	Norepinephrine	27-40	erythropoietin	Homo sapiens	0-14
18321934-11	2008	Sympathetic activation and elevation of the plasma noradrenaline concentration in obstructive sleep apnoea syndrome may be one of the factors involved in disorders of Period1 mRNA expression.	Norepinephrine	51-64	period circadian regulator 1	Homo sapiens	167-174
18598300-0	2008	Geniposide enhances melanogenesis by stem cell factor/c-Kit signalling in norepinephrine-exposed normal human epidermal melanocyte.	Norepinephrine	74-88	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	54-59
18598300-2	2008	Stem cell factor from keratinocyte recognizes and activates its receptor c-kit carried by melanocyte to potent enhance melanocytic melanogenesis that can be suppressed by norepinephrine.	Norepinephrine	171-185	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	73-78
18598300-4	2008	Flow cytometry results from this study exhibited the augmentation effect of geniposide on production of c-kit receptor by norepinephrine-exposed normal human epidermal melanocyte.	Norepinephrine	122-136	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	104-109
18598300-6	2008	ELISA indicated that at the presence of stem cell factor, geniposide was capable of elevating the level of extracellular signal-regulated kinase 1/2 phosphorylation within norepinephrine-exposed normal human epidermal melanocyte, which is known to be involved in stem cell factor/c-kit downstream signalling.	Norepinephrine	172-186	mitogen-activated protein kinase 3	Homo sapiens	107-146
18598300-9	2008	Data from this study suggest that geniposide can enhance melanogenesis by stem cell factor/c-kit signalling in which the expression of c-kit receptor is augmented in norepinephrine-exposed normal human epidermal melanocyte.	Norepinephrine	166-180	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	91-96
18598300-9	2008	Data from this study suggest that geniposide can enhance melanogenesis by stem cell factor/c-kit signalling in which the expression of c-kit receptor is augmented in norepinephrine-exposed normal human epidermal melanocyte.	Norepinephrine	166-180	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	135-140
18485637-0	2008	Evidence that geniposide abrogates norepinephrine-induced hypopigmentation by the activation of GLP-1R-dependent c-kit receptor signaling in melanocyte.	Norepinephrine	35-49	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	113-118
18607738-1	2008	Salt loading in adult mammals leads to increased vasopressin secretion by vasopressinergic neurons in the supraoptic nucleus, which is mediated by the actions of a number of hormones and neurotransmitters, including noradrenaline.	Norepinephrine	216-229	arginine vasopressin	Rattus norvegicus	49-60
18495360-5	2008	This difference in exploratory behavior correlated with genotype specific changes in REM and deregulated release of norepinephrine in the cortex and basal amygdala of the Rim1 alpha KO mice.	Norepinephrine	116-130	regulating synaptic membrane exocytosis 1	Mus musculus	171-181
18495360-7	2008	As norepinephrine plays an important role in regulating arousal and REM sleep, our data suggest that noradrenergic deficiency in Rim1 alpha KO animals impacts exploratory behavior and sleep regulation and contributes to impairments in learning.	Norepinephrine	3-17	regulating synaptic membrane exocytosis 1	Mus musculus	129-139
18485637-2	2008	Interaction of c-kit receptor with its ligand-SCF potent enhances the melanocytic melanogenesis, which can be repressed by norepinephrine (NE).	Norepinephrine	123-137	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	15-20
18440707-3	2008	To analyze further the involvement of ACTH in regulation of gene expression of norepinephrine (NE) biosynthetic enzymes, we examined the effect of bilateral adrenalectomy (ADX) of Sprague-Dawley male rats.	Norepinephrine	79-93	proopiomelanocortin	Homo sapiens	38-42
18423439-2	2008	When corticotropin-releasing factor was given at 0.5, 1.5, and 3.0 nmol/animal intracerebroventricularly, it dose-dependently increased noradrenaline release but not adrenaline release in the hypothalamic paraventricular nucleus.	Norepinephrine	136-149	corticotropin releasing hormone	Rattus norvegicus	5-35
18423439-4	2008	In addition, the corticotropin-releasing factor-induced elevation of noradrenaline release in the hypothalamic paraventricular nucleus and plasma corticosterone were abolished by hexamethonium, a non-selective nicotinic acetylcholine receptor antagonist, at 1.8 micromol/animal, intracerebroventricularly, and alpha-conotoxin MII, a potent alpha(3)beta(2) nicotinic acetylcholine receptor antagonist, at 30 nmol/animal, i.c.v.	Norepinephrine	69-82	corticotropin releasing hormone	Rattus norvegicus	17-47
18441198-0	2008	Inhibitory effect of D1-like and D3 dopamine receptors on norepinephrine-induced proliferation in vascular smooth muscle cells.	Norepinephrine	58-72	dopamine receptor D3	Rattus norvegicus	21-54
18414394-11	2008	The 5-HT transporter substrate, (+)-fenfluramine, released endogenous 5-HT from peripheral arteries, which potentiated noradrenaline-induced arterial contraction.	Norepinephrine	119-132	solute carrier family 6 member 4	Rattus norvegicus	4-20
18329701-1	2008	The antialcoholism drug disulfiram has shown recent promise as a pharmacotherapy for treating cocaine dependence, probably via inhibition of dopamine beta-hydroxylase (DBH), the enzyme that catalyzes the conversion of dopamine (DA) to norepinephrine (NE).	Norepinephrine	235-249	dopamine beta hydroxylase	Mus musculus	141-166
18430612-10	2008	Norepinephrine was elevated in p75-/- atria, but stimulating norepinephrine release with tyramine produced less tachycardia in p75-/- mice than wild type mice.	Norepinephrine	0-14	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	31-34
18430612-10	2008	Norepinephrine was elevated in p75-/- atria, but stimulating norepinephrine release with tyramine produced less tachycardia in p75-/- mice than wild type mice.	Norepinephrine	61-75	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	127-130
18480676-3	2008	Among these are several genes associated with the catecholaminergic system including the dopamine receptor genes (DRD4 and DRD5), the dopamine transporter gene, and the gene for dopamine beta-hydroxylase, which catalyzes conversion of dopamine to norepinephrine.	Norepinephrine	247-261	dopamine receptor D5	Homo sapiens	123-127
18329701-1	2008	The antialcoholism drug disulfiram has shown recent promise as a pharmacotherapy for treating cocaine dependence, probably via inhibition of dopamine beta-hydroxylase (DBH), the enzyme that catalyzes the conversion of dopamine (DA) to norepinephrine (NE).	Norepinephrine	235-249	dopamine beta hydroxylase	Mus musculus	168-171
18177483-0	2008	Chronic noradrenaline increases renal expression of NHE-3, NBC-1, BSC-1 and aquaporin-2.	Norepinephrine	8-21	solute carrier family 4 member 4	Rattus norvegicus	59-64
18177483-13	2008	We conclude that noradrenaline-induced increases in the expression of NHE-3, NBC-1, BSC-1 and aquaporin-2 are likely to play an important role in the regulation of salt and water transport by noradrenaline in the kidney and may explain, at least in part, the altered renal sodium and water handling associated with overactivation of the sympathetic system.	Norepinephrine	17-30	solute carrier family 4 member 4	Rattus norvegicus	77-82
18177483-13	2008	We conclude that noradrenaline-induced increases in the expression of NHE-3, NBC-1, BSC-1 and aquaporin-2 are likely to play an important role in the regulation of salt and water transport by noradrenaline in the kidney and may explain, at least in part, the altered renal sodium and water handling associated with overactivation of the sympathetic system.	Norepinephrine	192-205	solute carrier family 4 member 4	Rattus norvegicus	77-82
18182557-4	2008	We confirmed that TAAR1 was activated by trace amines and demonstrated that TAAR1 activation by beta-PEA significantly inhibited uptake and induced efflux of [3H]dopamine, [3H]norepinephrine, and [3H]serotonin in transfected cells.	Norepinephrine	176-190	trace amine-associated receptor 1	Mus musculus	18-23
18280616-0	2008	Effects of chlordiazepoxide on footshock- and corticotropin-releasing factor-induced increases in cortical and hypothalamic norepinephrine secretion in rats.	Norepinephrine	124-138	corticotropin releasing hormone	Rattus norvegicus	31-76
18182557-4	2008	We confirmed that TAAR1 was activated by trace amines and demonstrated that TAAR1 activation by beta-PEA significantly inhibited uptake and induced efflux of [3H]dopamine, [3H]norepinephrine, and [3H]serotonin in transfected cells.	Norepinephrine	176-190	trace amine-associated receptor 1	Mus musculus	76-81
18310473-8	2008	By comparing the effects of dopamine, norepinephrine, and serotonin in monkey and wild-type mouse synaptosomes to their effects in TAAR1 knockout mouse synaptosomes, we deduced that TAAR1 activity inhibited uptake and promoted efflux by monoamine transporters and that monoamine autoreceptors exerted opposite effects.	Norepinephrine	38-52	trace amine-associated receptor 1	Mus musculus	182-187
18234185-5	2008	In the present experiment, therefore, we examined (1) a role of the brain 2-arachidonoyl-sn-glycerol as a precursor of arachidonic acid in the centrally administered vasopressin-induced elevation of plasma noradrenaline and adrenaline, and (2) a regulatory role of the brain 2-arachidonoyl-sn-glycerol as an endocannabinoid on the vasopressin-induced response, using urethane-anesthetized rats.	Norepinephrine	206-219	arginine vasopressin	Rattus norvegicus	166-177
18598289-7	2008	3 In vas deferens from alpha(1D)-KO mice, the contractile response to low concentrations of noradrenaline and the contractile response to a single stimulus were significantly reduced as compared to wild type (WT).	Norepinephrine	92-105	arginine vasopressin	Rattus norvegicus	5-8
17481661-8	2008	In addition, we have examined tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of norepinephrine.	Norepinephrine	102-116	tyrosine hydroxylase	Homo sapiens	30-50
17481661-8	2008	In addition, we have examined tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of norepinephrine.	Norepinephrine	102-116	tyrosine hydroxylase	Homo sapiens	52-54
17481661-11	2008	Lower levels of NR1 subunit of the NMDA receptor in the LC implicates altered glutamate-norepinephrine interactions in alcoholism.	Norepinephrine	88-102	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	16-19
18234185-2	2008	administered arginine-vasopressin evokes the secretion of noradrenaline and adrenaline from adrenal medulla through the brain phospholipase C- and diacylglycerol-mediated and cyclooxygenase-mediated mechanisms in rats.	Norepinephrine	58-71	arginine vasopressin	Rattus norvegicus	22-33
18256139-0	2008	Whole body norepinephrine kinetics in ANG II-salt hypertension in the rat.	Norepinephrine	11-25	angiotensinogen	Rattus norvegicus	38-44
17664042-0	2008	Neurotensin-produced antinociception in the rostral ventromedial medulla is partially mediated by spinal cord norepinephrine.	Norepinephrine	110-124	neurotensin	Homo sapiens	0-11
17981009-2	2008	Recent work from our laboratory and others have shown that the catecholamine hormone, norepinephrine (NE), may influence tumor progression of some solid epithelial tumors including nasopharyngeal carcinoma (NPC) and ovarian cancer by modulating the expression of proangiogenic and pro-metastatic factors, such as vascular endothelial growth factor (VEGF).	Norepinephrine	86-100	vascular endothelial growth factor A	Homo sapiens	313-347
18328837-7	2008	Increased norepinephrine responses were related to larger CRP and IL-6 increases to mental challenge tasks (p values <0.05).	Norepinephrine	10-24	C-reactive protein	Homo sapiens	58-61
18328837-7	2008	Increased norepinephrine responses were related to larger CRP and IL-6 increases to mental challenge tasks (p values <0.05).	Norepinephrine	10-24	interleukin 6	Homo sapiens	66-70
18368304-8	2008	It can be administered orally, unlike noradrenaline, and after absorption is converted by the enzyme dopa decarboxylase into noradrenaline thus increasing levels of the neurotransmitter which is identical to endogenous noradrenaline.	Norepinephrine	125-138	dopa decarboxylase	Homo sapiens	101-119
18368304-8	2008	It can be administered orally, unlike noradrenaline, and after absorption is converted by the enzyme dopa decarboxylase into noradrenaline thus increasing levels of the neurotransmitter which is identical to endogenous noradrenaline.	Norepinephrine	125-138	dopa decarboxylase	Homo sapiens	101-119
17981009-0	2008	VEGF is differentially regulated in multiple myeloma-derived cell lines by norepinephrine.	Norepinephrine	75-89	vascular endothelial growth factor A	Homo sapiens	0-4
17981009-2	2008	Recent work from our laboratory and others have shown that the catecholamine hormone, norepinephrine (NE), may influence tumor progression of some solid epithelial tumors including nasopharyngeal carcinoma (NPC) and ovarian cancer by modulating the expression of proangiogenic and pro-metastatic factors, such as vascular endothelial growth factor (VEGF).	Norepinephrine	86-100	vascular endothelial growth factor A	Homo sapiens	349-353
17991694-7	2008	Suppressed responsiveness of the CRH neurones, and hence the HPA axis, following IL-1beta in late pregnancy is explained by presynaptic inhibition of noradrenaline release in the pPVN, due to increased endogenous enkephalin and mu-opioid receptor production in brainstem NTS neurones.	Norepinephrine	150-163	corticotropin releasing hormone	Rattus norvegicus	33-36
18023073-2	2008	The purpose of the present study was to determine whether the tyrosine hydroxylase (TH) val81met and catechol-O-methyltransferase (COMT) val158met polymorphisms are associated with the antidepressant effect of milnacipran, a serotonin/noradrenaline reuptake inhibitor.	Norepinephrine	235-248	tyrosine hydroxylase	Homo sapiens	62-82
18023073-2	2008	The purpose of the present study was to determine whether the tyrosine hydroxylase (TH) val81met and catechol-O-methyltransferase (COMT) val158met polymorphisms are associated with the antidepressant effect of milnacipran, a serotonin/noradrenaline reuptake inhibitor.	Norepinephrine	235-248	tyrosine hydroxylase	Homo sapiens	84-86
18235090-1	2008	Chromogranin A is released together with epinephrine and norepinephrine from catecholaminergic cells.	Norepinephrine	57-71	chromogranin A	Homo sapiens	0-14
18328125-2	2008	METHODS: The superior mesenteric artery (SMA) obtained from rats in hemorrhagic shock for different time duration (immediately, 0.5 hour, 1 hour, 2 hours and 4 hours after shock) were adopted to determine the mRNA expression of PKC epsilon using reverse transcription-polymerase chain reaction (RT-PCR) technique, and the first branch of SMA were adopted to assay the vascular reactivity and calcium sensitivity by observing the contraction initiated by norepinephrine (NE) and Ca2+ with isolated organ perfusion system.	Norepinephrine	454-468	protein kinase C, epsilon	Rattus norvegicus	228-239
17896794-2	2008	The rate-limiting step in the biosynthesis of dopamine, noradrenalin, and adrenalin is catalyzed by tyrosine 3-monooxygenase (=tyrosine hydroxylase), which catalyzes the formation of L-DOPA.	Norepinephrine	56-68	tyrosine hydroxylase	Homo sapiens	100-124
18083901-4	2008	We identified the expression of the paxillin homologue hydrogen peroxide-inducible clone-5 (Hic-5) and showed its activation by norepinephrine (NE) in a Src-dependent manner.	Norepinephrine	128-142	transforming growth factor beta 1 induced transcript 1	Rattus norvegicus	92-97
18308800-11	2008	Reversal of impaired executive function by a NET inhibitor implicates the NET and norepinephrine in MDMA-induced cognitive impairment and may be relevant to therapeutic strategies.	Norepinephrine	82-96	solute carrier family 6 member 2	Homo sapiens	45-48
17853072-11	2008	These results suggest that systemic epinephrine, perhaps by evoking central norepinephrine release, modulates the increase in forebrain GABAA receptor binding induced by both insulin and stress.	Norepinephrine	76-90	insulin	Gallus gallus	175-182
18056263-0	2008	Norepinephrine- and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytes.	Norepinephrine	0-14	G protein-coupled receptor kinase 2	Homo sapiens	93-97
17991694-7	2008	Suppressed responsiveness of the CRH neurones, and hence the HPA axis, following IL-1beta in late pregnancy is explained by presynaptic inhibition of noradrenaline release in the pPVN, due to increased endogenous enkephalin and mu-opioid receptor production in brainstem NTS neurones.	Norepinephrine	150-163	interleukin 1 beta	Rattus norvegicus	81-89
21188136-4	2008	With comparable contraction responses in PA, endothelin-1 (100 nM) and norepinephrine (1 muM) induced a 2-fold increase of P-CF/CF, while angiotensin II (1 muM) induced none.	Norepinephrine	71-85	latexin	Homo sapiens	89-92
17942572-6	2008	In ApoE-KO mouse kidneys, compared with C57BL6, a specific decrease in norepinephrine response and no modification in dilator responses were observed.	Norepinephrine	71-85	apolipoprotein E	Mus musculus	3-7
17975121-3	2008	METHODS AND RESULTS: Norepinephrine and epinephrine, added to aortic smooth muscle cells (ASMCs) in vitro, altered Per1, E4bp4, and dbp expression and altered the observed oscillations in clock gene expression.	Norepinephrine	21-35	D site albumin promoter binding protein	Mus musculus	132-135
17915215-5	2008	IGF-I had no significant effect by itself on these parameters but markedly reduced the effects of noradrenaline.	Norepinephrine	98-111	insulin like growth factor 1	Homo sapiens	0-5
18608197-0	2008	Effects on plasma noradrenaline may explain some of the improved insulin sensitivity seen by AT-1 receptor blockade.	Norepinephrine	18-31	insulin	Homo sapiens	65-72
18257749-2	2008	2 Inhibitors of this kinase (PP2 and Src Inhibitor II) decreased ( approximately 50-75%) noradrenaline- (NA) and phorbol myristate acetate-mediated receptor phosphorylation.	Norepinephrine	89-102	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	37-40
18032527-12	2008	NPY and TH in vascular sympathetic nerves are likely to modulate NPY and/or norepinephrine release from these nerves and are thus likely to affect blood flow and blood pressure.	Norepinephrine	76-90	neuropeptide Y	Rattus norvegicus	0-3
18608197-8	2008	CONCLUSION: The results may suggest that improvement of insulin sensitivity by ARB is related to decreased plasma noradrenaline and potential sympatholytic effects.	Norepinephrine	114-127	insulin	Homo sapiens	56-63
18064421-4	2008	Presynaptic receptors for ACTH (MC(2) receptors) have so far been identified almost exclusively in cardiovascular tissues from rabbits, where they facilitate noradrenaline release; they are coupled to G(s) protein and act via stimulation of adenylyl cyclase.	Norepinephrine	158-171	proopiomelanocortin	Homo sapiens	26-30
19012528-1	2008	BACKGROUND: Biogenic amine, adrenaline, noradrenaline, dopamine and 5-hydroxy-tryptamine (5-HT) levels are related to interleukin-6 (IL-6) plasma concentrations and endurance exercise.	Norepinephrine	40-53	interleukin 6	Homo sapiens	118-131
19012528-1	2008	BACKGROUND: Biogenic amine, adrenaline, noradrenaline, dopamine and 5-hydroxy-tryptamine (5-HT) levels are related to interleukin-6 (IL-6) plasma concentrations and endurance exercise.	Norepinephrine	40-53	interleukin 6	Homo sapiens	133-137
18087164-2	2008	Ischemia/reperfusion releases this renin leading to local angiotensin formation and norepinephrine release.	Norepinephrine	84-98	renin	Homo sapiens	35-40
18061980-6	2008	RESULTS: In healthy subjects, systemic CHGA levels correlated positively with age and plasma norepinephrine, indicating the sympathetic origin (p < 0.01).	Norepinephrine	93-107	chromogranin A	Homo sapiens	39-43
17804485-1	2007	Neuropeptide Y (NPY) is coreleased with norepinephrine and stimulates vasoconstriction, vascular and cardiomyocyte hypertrophy via Y1 receptors (R) and angiogenesis via Y2R.	Norepinephrine	40-54	neuropeptide Y	Rattus norvegicus	0-14
17804485-1	2007	Neuropeptide Y (NPY) is coreleased with norepinephrine and stimulates vasoconstriction, vascular and cardiomyocyte hypertrophy via Y1 receptors (R) and angiogenesis via Y2R.	Norepinephrine	40-54	neuropeptide Y	Rattus norvegicus	16-19
17898122-11	2007	However, phosphorylation of p38 MAPK induced by norepinephrine or endothelin-1 was reduced in vessels treated with Ado, whereas 20-kDa myosin light chain was unchanged.	Norepinephrine	48-62	mitogen-activated protein kinase 14	Homo sapiens	28-31
18006623-1	2007	UNLABELLED: The activation of the renin-angiotensin-aldosterone system prevents the uptake of norepinephrine in the myocardium.	Norepinephrine	94-108	renin	Homo sapiens	34-39
17712549-7	2007	SERT -/- mice also exhibit altered behavioral responses to cocaine and ethanol, related to abnormal serotonin, and possibly dopamine and norepinephrine, homeostasis.	Norepinephrine	137-151	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	0-4
17974982-10	2007	These studies show IL-6-independent activation of STAT3 by norepinephrine and epinephrine, proceeding through the beta1/beta2-adrenergic receptors and protein kinase A, resulting in increased matrix metalloproteinase production, invasion, and in vivo tumor growth, which can be ameliorated by the down-regulation of STAT3.	Norepinephrine	59-73	signal transducer and activator of transcription 3	Mus musculus	50-55
17974982-10	2007	These studies show IL-6-independent activation of STAT3 by norepinephrine and epinephrine, proceeding through the beta1/beta2-adrenergic receptors and protein kinase A, resulting in increased matrix metalloproteinase production, invasion, and in vivo tumor growth, which can be ameliorated by the down-regulation of STAT3.	Norepinephrine	59-73	signal transducer and activator of transcription 3	Mus musculus	316-321
18093411-3	2007	Angiotensin II also stimulates noradrenaline release modulated by presynaptic receptors on sympathetic nerves.	Norepinephrine	31-44	angiotensinogen	Homo sapiens	0-14
17673606-1	2007	Desvenlafaxine succinate (DVS) is a recently introduced antagonist of the human norepinephrine and serotonin transporters (hNET and hSERT, respectively), currently in clinical development for use in the treatment of major depressive disorder and vasomotor symptoms associated with menopause.	Norepinephrine	80-94	solute carrier family 6 member 2	Homo sapiens	123-127
17673199-6	2007	The selective norepinephrine transporter blocker (20 mg/kg nisoxetine) caused hyperthermia in DAT/SERT double KO mice, suggesting that the norepinephrine system is not responsible for methamphetamine-induced paradoxical hypothermia in the double KO mice.	Norepinephrine	14-28	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	94-97
17673199-6	2007	The selective norepinephrine transporter blocker (20 mg/kg nisoxetine) caused hyperthermia in DAT/SERT double KO mice, suggesting that the norepinephrine system is not responsible for methamphetamine-induced paradoxical hypothermia in the double KO mice.	Norepinephrine	14-28	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	98-102
17890005-2	2007	The injection of norepinephrine (NE) into the prelimbic (PL) area of the MPFC of unanesthetized rats evokes a pressor response which is mediated by acute vasopressin release.	Norepinephrine	17-31	arginine vasopressin	Rattus norvegicus	154-165
17584982-4	2007	In this work, we studied the role of changes in norepinephrine (NE) level on the lipopolysaccharide (LPS) evoked tumor necrosis factor (TNF)-alpha and interleukin (IL)-10 response both in the plasma and in the hippocampus of mice.	Norepinephrine	48-62	toll-like receptor 4	Mus musculus	101-104
17584982-4	2007	In this work, we studied the role of changes in norepinephrine (NE) level on the lipopolysaccharide (LPS) evoked tumor necrosis factor (TNF)-alpha and interleukin (IL)-10 response both in the plasma and in the hippocampus of mice.	Norepinephrine	48-62	tumor necrosis factor	Mus musculus	113-146
17584982-4	2007	In this work, we studied the role of changes in norepinephrine (NE) level on the lipopolysaccharide (LPS) evoked tumor necrosis factor (TNF)-alpha and interleukin (IL)-10 response both in the plasma and in the hippocampus of mice.	Norepinephrine	48-62	interleukin 10	Mus musculus	151-170
17684049-1	2007	CONTEXT: Older studies have shown that high doses of norepinephrine infused into human subjects can inhibit insulin secretion.	Norepinephrine	53-67	insulin	Homo sapiens	108-115
17664025-1	2007	Alpha2-adrenoceptors belong to the group of nine adrenoceptors which mediate the biological actions of the endogenous catecholamines adrenaline and noradrenaline.	Norepinephrine	148-161	adrenergic receptor, alpha 2a	Mus musculus	0-20
17206434-6	2007	For condition after CPR we found an adrenaline/noradrenaline quotient of 2.81 +/- 5.8.	Norepinephrine	47-60	cytochrome p450 oxidoreductase	Homo sapiens	20-23
17727392-8	2007	Plasma noradrenaline and dihydroxyphenylglycol concentrations were higher for yohimbine vs placebo and for GLP-1 and yohimbine vs GLP-1.	Norepinephrine	7-20	glucagon	Homo sapiens	107-112
17727392-8	2007	Plasma noradrenaline and dihydroxyphenylglycol concentrations were higher for yohimbine vs placebo and for GLP-1 and yohimbine vs GLP-1.	Norepinephrine	7-20	glucagon	Homo sapiens	130-135
17698732-12	2007	TH promoter haplotype 2 (TGGG) showed pleiotropy, increasing both norepinephrine excretion and blood pressure during stress.	Norepinephrine	66-80	tyrosine hydroxylase	Homo sapiens	0-2
17425514-6	2007	We observed the expected increases in renin concentration and aldosterone activity in subjects on the low-salt diet, and also observed a significantly less increase in plasma noradrenaline concentration during euglycaemic insulin infusion following the high-salt compared with the low-salt diet.	Norepinephrine	175-188	insulin	Homo sapiens	222-229
17425514-7	2007	We propose that the 4-5-fold increase in serum aldosterone and the greater increase in plasma noradrenaline concentration following the low-salt intervention compared with the high-salt period may have contributed to the differences in insulin sensitivity following the adjustment in dietary sodium intake.	Norepinephrine	94-107	insulin	Homo sapiens	236-243
17599007-3	2007	The vasoactive properties of vasopressin have been more applicable clinically because of the discovery by Landry and colleagues that there is a deficiency of vasopressin in septic shock and that infusion of relatively low doses of vasopressin improves responsiveness to infused catecholamines (such as norepinephrine).	Norepinephrine	302-316	arginine vasopressin	Homo sapiens	29-40
17599007-5	2007	The majority of studies found that vasopressin infusion increased blood pressure and urine output, and decreased the dose requirement of norepinephrine.	Norepinephrine	137-151	arginine vasopressin	Homo sapiens	35-46
17294189-2	2007	Chronic beta-adrenergic stimulation has been implicated in insulin resistance in cultured cardiomyocytes in vitro, where sustained noradrenaline stimulation inhibited insulin-modulated glucose uptake.	Norepinephrine	131-144	insulin	Homo sapiens	59-66
17294189-2	2007	Chronic beta-adrenergic stimulation has been implicated in insulin resistance in cultured cardiomyocytes in vitro, where sustained noradrenaline stimulation inhibited insulin-modulated glucose uptake.	Norepinephrine	131-144	insulin	Homo sapiens	167-174
17926913-8	2007	These data show that noradrenalin provides an inhibitory control of vasopressin expression at least since P3.	Norepinephrine	21-33	arginine vasopressin	Rattus norvegicus	68-79
17926913-10	2007	Thus, life by the increased expression of vasopressin that is postnatally under the inhibitory control by noradrenalin.	Norepinephrine	106-118	arginine vasopressin	Rattus norvegicus	42-53
17449311-8	2007	This is the first report of a cloned AANAT that acetylated norepinephrine.	Norepinephrine	59-73	arylalkylamine N-acetyltransferase	Bombyx mori	37-42
17531968-6	2007	To determine whether Hand2 regulates noradrenergic differentiation, the levels of the norepinephrine biosynthetic enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) was examined.	Norepinephrine	86-100	dopamine beta hydroxylase	Mus musculus	180-183
17508087-1	2007	A novel photochemical technique combined with mass spectrometry and resonant infrared multiphoton dissociation spectroscopy (R-IRMPD) has been used to record infrared vibrational spectra of the free protonated noradrenaline analogue, 2-amino-1-phenylethanol (APE-H(+)), the amino acid, lysine (Lys-H(+)), and the dipeptide, alanyl alanine (Ala-Ala-H(+)) in the gas phase.	Norepinephrine	210-223	acylaminoacyl-peptide hydrolase	Homo sapiens	259-268
17456983-6	2007	Patients with high cTnT had abnormally high blood concentrations of BNP (p<0.0001), ICTP (p<0.0001), PIIIP (p=0.0006), NOREPI (p=0.0119), CRP (p=0.0003), uric acid (p=0.0026) and HbA1c (p=0.0361).	Norepinephrine	125-131	troponin T2, cardiac type	Homo sapiens	19-23
17478765-13	2007	ET-1 may be indirectly play a role in SAM by cross-talking and potentiating the activities of other vasoconstrictors such as norepinephrine and by orchestrating its reparative phase.	Norepinephrine	125-139	endothelin 1	Homo sapiens	0-4
17432967-5	2007	Chronic PRL treatment exerted an anxiolytic effect on the elevated plus-maze, and attenuated the acute restraint-induced rise in plasma adrenocorticotropin, corticosterone and noradrenaline.	Norepinephrine	176-189	prolactin	Rattus norvegicus	8-11
17947354-1	2008	Corticotropin-releasing factor (CRF) activates locus coeruleus (LC)-norepinephrine neurons during stress.	Norepinephrine	68-82	corticotropin releasing hormone	Rattus norvegicus	0-30
17975126-9	2008	At 5 mo, when cardiac dysfunction is associated with lung edema and increased plasma norepinephrine levels, alpha(2A)/alpha(2C)ARKO mice presented reduced FS paralleled by decreased SERCA2 (26%) and NCX (34%).	Norepinephrine	85-99	adrenergic receptor, alpha 2a	Mus musculus	108-116
17975126-11	2008	ET in alpha(2A)/alpha(2C)ARKO mice prevented exercise intolerance, ventricular dysfunction, and decreased plasma norepinephrine.	Norepinephrine	113-127	adrenergic receptor, alpha 2a	Mus musculus	6-14
18451634-1	2008	The effect of insulin on the vasoconstriction induced by norepinephrine is at present controversial.	Norepinephrine	57-71	insulin	Homo sapiens	14-21
18451634-2	2008	We have previously demonstrated that high-concentration insulin may induce an increased reactivity to norepinephrine in mesenteric small resistance arteries of spontaneously hypertensive rats.	Norepinephrine	102-116	insulin	Homo sapiens	56-63
18451634-3	2008	The aim of the present study was to evaluate the effects of low- and high-concentration insulin on the concentration-response curves to norepinephrine and acetylcholine in subcutaneous small resistance arteries of hypertensive and diabetic patients.	Norepinephrine	136-150	insulin	Homo sapiens	88-95
18451634-7	2008	A significant reduction in the contractile response to norepinephrine was observed in NT after preincubation of the vessels with both low- and high-concentration insulin.	Norepinephrine	55-69	insulin	Homo sapiens	162-169
18451634-9	2008	Moreover, a significant difference in reduction in contractile response at maximal concentration of norepinephrine in the presence of low-concentration insulin was observed in NT compared to EH (p = 0.03), NIDDM (p = 0.02), and EH + NIDDM (p = 0.05), whereas no difference was observed with high-concentration insulin.	Norepinephrine	100-114	insulin	Homo sapiens	152-159
18451634-9	2008	Moreover, a significant difference in reduction in contractile response at maximal concentration of norepinephrine in the presence of low-concentration insulin was observed in NT compared to EH (p = 0.03), NIDDM (p = 0.02), and EH + NIDDM (p = 0.05), whereas no difference was observed with high-concentration insulin.	Norepinephrine	100-114	insulin	Homo sapiens	310-317
18451634-11	2008	In conclusion, insulin at low (physiological) concentrations seems to induce a decreased reactivity to norepinephrine in subcutaneous small resistance arteries of NT, but this effect was lost in EH, NIDDM and EH + NIDDM.	Norepinephrine	103-117	insulin	Homo sapiens	15-22
17853069-3	2008	Also, in the adrenal glands basal levels of tyrosine hydroxylase protein, the rate-limiting enzyme for catecholamine biosynthesis, and of phenylethanolamine N-methyltransferase, which converts norepinephrine to epinephrine, were significantly reduced in nNOS KO mice.	Norepinephrine	193-207	phenylethanolamine-N-methyltransferase	Mus musculus	138-176
18053221-13	2007	ESR1 rs532010 was associated with lipolytic sensitivity to noradrenaline (nominal P value 0.012), and ESR1 rs1884051 with responsiveness to the non-selective beta-adrenoceptor agonist isoprenaline (nominal P value 0.05).	Norepinephrine	59-72	estrogen receptor 1	Homo sapiens	0-4
17823252-8	2007	These results suggest that morphine withdrawal increases noradrenaline turnover in the PVN, at least in part, via ERK(1/2)-dependent phosphorylation of TH at Ser31.	Norepinephrine	57-70	mitogen-activated protein kinase 3	Homo sapiens	114-121
17854349-0	2007	Neuroprotective actions of noradrenaline: effects on glutathione synthesis and activation of peroxisome proliferator activated receptor delta.	Norepinephrine	27-40	peroxisome proliferator-activated receptor delta	Rattus norvegicus	93-141
17959316-7	2007	Increased TH expression was accompanied by a slight increase in noradrenaline content.	Norepinephrine	64-77	tyrosine hydroxylase	Homo sapiens	10-12
17974982-2	2007	We examined the effects of two mediators of stress, norepinephrine and epinephrine, on the activation of signal transducer and activator of transcription-3 (STAT3), a transcription factor that contributes to many promalignant pathways.	Norepinephrine	52-66	signal transducer and activator of transcription 3	Mus musculus	105-155
17974982-2	2007	We examined the effects of two mediators of stress, norepinephrine and epinephrine, on the activation of signal transducer and activator of transcription-3 (STAT3), a transcription factor that contributes to many promalignant pathways.	Norepinephrine	52-66	signal transducer and activator of transcription 3	Mus musculus	157-162
17974982-3	2007	Exposure of ovarian cancer cell lines to increasing concentrations of norepinephrine or epinephrine showed that both independently increased levels of phosphorylated STAT3 in a dose-dependent fashion.	Norepinephrine	70-84	signal transducer and activator of transcription 3	Mus musculus	166-171
17974982-4	2007	Immunolocalization and ELISA of nuclear extracts confirmed increased nuclear STAT3 in response to norepinephrine.	Norepinephrine	98-112	signal transducer and activator of transcription 3	Mus musculus	77-82
17974982-7	2007	Regarding the effects of STAT3 activation, exposure to norepinephrine resulted in an increase in invasion and matrix metalloproteinase (MMP-2 and MMP-9) production.	Norepinephrine	55-69	signal transducer and activator of transcription 3	Mus musculus	25-30
17974982-10	2007	These studies show IL-6-independent activation of STAT3 by norepinephrine and epinephrine, proceeding through the beta1/beta2-adrenergic receptors and protein kinase A, resulting in increased matrix metalloproteinase production, invasion, and in vivo tumor growth, which can be ameliorated by the down-regulation of STAT3.	Norepinephrine	59-73	interleukin 6	Mus musculus	19-23
17950110-5	2007	C-reactive protein infusion induced an inflammatory response, which was followed by increased plasma concentrations of norepinephrine (3 hours) and cortisol (4 hours).	Norepinephrine	119-133	C-reactive protein	Homo sapiens	0-18
17950110-8	2007	In conclusion, CRP infusion induces an inflammatory response followed by increased norepinephrine and cortisol levels, which results in increased gluconeogenesis.	Norepinephrine	83-97	C-reactive protein	Homo sapiens	15-18
17716980-3	2007	Here we show that stress hormones such as norepinephrine lead to increased expression of IL-6 mRNA and protein levels in ovarian carcinoma cells.	Norepinephrine	42-56	interleukin 6	Homo sapiens	89-93
17716980-4	2007	Furthermore, we demonstrate that norepinephrine stimulation activates Src tyrosine kinase and this activation is required for increased IL-6 expression.	Norepinephrine	33-47	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	70-73
17716980-4	2007	Furthermore, we demonstrate that norepinephrine stimulation activates Src tyrosine kinase and this activation is required for increased IL-6 expression.	Norepinephrine	33-47	interleukin 6	Homo sapiens	136-140
17603545-8	2007	Contractile tension of the vas deferens in response to noradrenaline was markedly decreased in alpha(1A)-adrenoceptor KO mice, and this contraction was completely abolished in alpha(1)-adrenoceptor triple-KO mice.	Norepinephrine	55-68	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	95-103
17879086-0	2007	Stress-induced release of substance P in the locus coeruleus modulates cortical noradrenaline release.	Norepinephrine	80-93	tachykinin precursor 1	Homo sapiens	26-37
17632098-6	2007	In norepinephrine-precontracted rabbit aortic rings, NCX 6560-induced vasodilation (EC(50)=53.5+/-8.3 microM) and in PC12 cells it stimulated cGMP formation (EC(50)=1.8+/-0.7 microM), while atorvastatin was inactive.	Norepinephrine	3-17	solute carrier family 8 member A1	Rattus norvegicus	53-56
17728423-0	2007	Association of a serotonin transporter polymorphism (5-HTTLPR) with depression, perceived stress, and norepinephrine in patients with coronary disease: the Heart and Soul Study.	Norepinephrine	102-116	solute carrier family 6 member 4	Homo sapiens	17-38
17728423-0	2007	Association of a serotonin transporter polymorphism (5-HTTLPR) with depression, perceived stress, and norepinephrine in patients with coronary disease: the Heart and Soul Study.	Norepinephrine	102-116	solute carrier family 6 member 4	Homo sapiens	53-61
17728423-8	2007	CONCLUSIONS: Among patients with chronic illness, carriers of the s allele of 5-HTTLPR are more vulnerable to depression, perceived stress, and high norepinephrine secretion.	Norepinephrine	149-163	solute carrier family 6 member 4	Homo sapiens	78-86
30736127-6	2007	Specifically, in brown adipocytes, PPARgamma promotes the transcription of genes involved in thermogenesis, such as mitochondrial uncoupling protein (UCP) 1, resulting in enhanced noradrenaline-dependent thermogenesis.	Norepinephrine	180-193	peroxisome proliferator activated receptor gamma	Homo sapiens	35-44
17363078-2	2007	We have previously reported that endothelin-1 and -3 (ET-1 and ET-3) modulate norepinephrine release in the anterior and posterior hypothalamus.	Norepinephrine	78-92	endothelin 1	Rattus norvegicus	33-52
17363078-2	2007	We have previously reported that endothelin-1 and -3 (ET-1 and ET-3) modulate norepinephrine release in the anterior and posterior hypothalamus.	Norepinephrine	78-92	endothelin 1	Rattus norvegicus	54-67
17602602-3	2007	In general, the compounds showed higher dopamine transporter (DAT) affinity relative to the serotonin and norepinephrine transporters (SERT and NET, respectively) and greater [3H]dopamine uptake inhibition potency relative to [3H]serotonin and [3H]norepinephrine uptake inhibition.	Norepinephrine	106-120	solute carrier family 6 member 4	Rattus norvegicus	135-139
17481608-5	2007	Pretreatment with the selective serotonin reuptake inhibitor fluvoxamine, the relatively selective noradrenaline reuptake inhibitor reboxetine, or the non-selective monoaminergic reuptake inhibitor imipramine, significantly inhibited IL-6 and NO production in a dose-dependent manner.	Norepinephrine	99-112	interleukin 6	Mus musculus	234-238
17394554-0	2007	Noradrenaline enhances the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of PI3K/Akt and the mTOR/S6K pathway.	Norepinephrine	0-13	AKT serine/threonine kinase 1	Homo sapiens	139-142
17394554-0	2007	Noradrenaline enhances the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of PI3K/Akt and the mTOR/S6K pathway.	Norepinephrine	0-13	mechanistic target of rapamycin kinase	Homo sapiens	151-155
17429342-8	2007	Norepinephrine increased PAI-1 expression in WT heart and aorta, and in AT(1a)-/- heart, kidney, and liver with no effect of losartan.	Norepinephrine	0-14	angiotensin II receptor, type 1a	Mus musculus	72-77
17429342-11	2007	Further, norepinephrine induces PAI-1 expression in vivo with AT(1a) receptor deficiency modulating the effect.	Norepinephrine	9-23	angiotensin II receptor, type 1a	Mus musculus	62-67
17350615-0	2007	Adrenal adrenaline- and noradrenaline-containing cells and celiac sympathetic ganglia are differentially controlled by centrally administered corticotropin-releasing factor and arginine-vasopressin in rats.	Norepinephrine	24-37	corticotropin releasing hormone	Rattus norvegicus	142-172
17379416-9	2007	When VP was added to an existing infusion of norepinephrine (NE), there was a significant NE sparing effect.	Norepinephrine	45-59	arginine vasopressin	Homo sapiens	5-7
17514581-0	2007	Effect of peripherally administered lipopolysaccharide (LPS) on GTP cyclohydrolase I, tetrahydrobiopterin and norepinephrine in the locus coeruleus in mice.	Norepinephrine	110-124	toll-like receptor 4	Mus musculus	56-59
17514581-3	2007	Furthermore, we observed that gene expression of GCH in the locus coeruleus (LC) in mice was enhanced by peripheral administration of LPS, resulting in increased concentrations of BH4, and norepinephrine, and its metabolite 4-hydroxy-3-methoxyphenylglycol (MHPG).	Norepinephrine	189-203	toll-like receptor 4	Mus musculus	134-137
17514581-5	2007	LPS in blood may act as a stressor to increase norepinephrine biosynthesis in the mouse LC.	Norepinephrine	47-61	toll-like receptor 4	Mus musculus	0-3
17485013-1	2007	BACKGROUND: The aim of the present study was to evaluate the intervention of COX-1- and COX-2-derived prostaglandins in the responses of human gastroepiploic artery to sympathetic stimulation and norepinephrine.	Norepinephrine	196-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
17425612-0	2007	Noradrenaline release in the medial preoptic area during the rat oestrous cycle: temporal relationship with plasma secretory surges of prolactin and luteinising hormone.	Norepinephrine	0-13	prolactin	Rattus norvegicus	135-144
17425612-6	2007	Correlating with noradrenaline release in the MPOA, plasma prolactin surges occurred during the afternoons of both pro-oestrous and oestrous.	Norepinephrine	17-30	prolactin	Rattus norvegicus	59-68
17425612-8	2007	A temporal association between noradrenaline release and prolactin secretion suggests that noradrenergic neurotransmission in the MPOA regulates prolactin surges in female rats.	Norepinephrine	31-44	prolactin	Rattus norvegicus	57-66
17425612-8	2007	A temporal association between noradrenaline release and prolactin secretion suggests that noradrenergic neurotransmission in the MPOA regulates prolactin surges in female rats.	Norepinephrine	31-44	prolactin	Rattus norvegicus	145-154
17379857-1	2007	The noradrenaline transporter (NET) is a Na(+)/Cl(-) dependent monoamine transporter that mediates rapid clearance of noradrenaline from the synaptic cleft, thereby terminating neuronal signaling.	Norepinephrine	4-17	solute carrier family 6 member 2	Homo sapiens	31-34
17318500-0	2007	The effects of both noradrenaline and CGP12177, mediated through human beta1 -adrenoceptors, are reduced by PDE3 in human atrium but PDE4 in CHO cells.	Norepinephrine	20-33	phosphodiesterase 4A	Homo sapiens	133-137
17318500-2	2007	The positive inotropic effects of (-)-noradrenaline are blunted by phosphodiesterase4 (PDE4) but not PDE3, while both PDE isoenzymes, acting in concert, prevent the effects of (-)-CGP12177 through beta(1)-adrenoceptors in rat ventricle.	Norepinephrine	34-51	phosphodiesterase 4A	Homo sapiens	87-91
17318500-10	2007	However, in CHO cells, PDE4 blunts the cAMP signals of both (-)-noradrenaline and (-)-CGP12177.	Norepinephrine	60-77	phosphodiesterase 4A	Homo sapiens	23-27
17280595-1	2007	Noradrenaline or serotonin (5-HT) reuptake-inhibiting antidepressants such as reboxetine or citalopram acutely stimulate cortisol and adrenocorticotrophic hormone (ACTH) secretion in healthy volunteers, whereas mirtazapine acutely inhibits the ACTH and cortisol release, probably due to its antagonism at central 5-HT(2) and/or H(1) receptors.	Norepinephrine	0-13	proopiomelanocortin	Homo sapiens	164-168
17280595-1	2007	Noradrenaline or serotonin (5-HT) reuptake-inhibiting antidepressants such as reboxetine or citalopram acutely stimulate cortisol and adrenocorticotrophic hormone (ACTH) secretion in healthy volunteers, whereas mirtazapine acutely inhibits the ACTH and cortisol release, probably due to its antagonism at central 5-HT(2) and/or H(1) receptors.	Norepinephrine	0-13	proopiomelanocortin	Homo sapiens	244-248
18087164-7	2008	Renin inhibition with BILA2157 did not affect mast cell degranulation, but attenuated norepinephrine release.	Norepinephrine	86-100	renin	Homo sapiens	0-5
18087164-8	2008	CONCLUSIONS: Our findings disclose that immediate-type hypersensitivity elicits renin release from mast cells, activating a local renin-angiotensin system, thereby promoting norepinephrine release.	Norepinephrine	174-188	renin	Homo sapiens	80-85
18087164-8	2008	CONCLUSIONS: Our findings disclose that immediate-type hypersensitivity elicits renin release from mast cells, activating a local renin-angiotensin system, thereby promoting norepinephrine release.	Norepinephrine	174-188	renin	Homo sapiens	130-135
17295024-1	2007	Activation of either coexisting beta1- or beta2 -adrenoceptors with noradrenaline or adrenaline, respectively, causes maximum increases of contractility of human atrial myocardium.	Norepinephrine	68-81	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	32-37
17179444-10	2007	The receptor agonist noradrenaline, which induced a rapid increase in the [Ca2+]i and Ca2+-dependent contraction, stimulated phosphorylation of MYPT1 and MLC, which was also dependent on Ca2+, PI3K-C2alpha, and Rho-kinase.	Norepinephrine	21-34	modulator of VRAC current 1	Homo sapiens	154-157
17295024-7	2007	For comparison, beta1 -adrenoceptor-mediated effects of (-)-noradrenaline were investigated in the presence of ICI 118,551 (50 nM to block beta2 -adrenoceptors).	Norepinephrine	56-73	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	16-21
17230457-2	2007	We report clinical and polysomnographic accounts of a patient developing RLS augmentation after long-term treatment with tramadol, an opioid agonist with selectivity for mu-receptor and added norepinephrine and serotonin reuptake inhibition properties.	Norepinephrine	192-206	RLS1	Homo sapiens	73-76
17194545-1	2007	Previous studies have shown that corticotropin-releasing factor (CRF), an integral mediator of the stress response, and opioids regulate the activity of the locus-coeruleus-norepinephrine (LC-NE) system during stress in a reciprocal manner.	Norepinephrine	173-187	corticotropin releasing hormone	Rattus norvegicus	33-63
17242628-1	2007	BACKGROUND: Atomoxetine, a selective norepinephrine reuptake inhibitor effective in the treatment of attention-deficit/hyperactivity disorder (ADHD), is metabolized through the cytochrome P-450 2D6 (CYP2D6) enzyme pathway, which is genetically polymorphic in humans.	Norepinephrine	37-51	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	177-197
17242628-1	2007	BACKGROUND: Atomoxetine, a selective norepinephrine reuptake inhibitor effective in the treatment of attention-deficit/hyperactivity disorder (ADHD), is metabolized through the cytochrome P-450 2D6 (CYP2D6) enzyme pathway, which is genetically polymorphic in humans.	Norepinephrine	37-51	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	199-205
17207896-4	2007	The aim of the present study was to determine the interaction between NPY and IL-1beta in catecholamine (norepinephrine, NE and epinephrine, EP) release from mouse chromaffin cells in culture.	Norepinephrine	105-119	interleukin 1 beta	Mus musculus	78-86
17224717-3	2007	The current study measured SERT occupancy and modulation of DAT by the serotonin/norepinephrine reuptake inhibitor (SNRI) venlafaxine using [123I]2beta-carbomethoxy-3beta-(4-iodophenyl)-tropane SPECT.	Norepinephrine	81-95	solute carrier family 6 member 4	Homo sapiens	27-31
17211240-9	2007	In established hypertension, elevated CRP was associated with increased BP, BMI, insulin, HOMA (index of insulin resistance), leptin, triglycerides and norepinephrine.	Norepinephrine	152-166	C-reactive protein	Homo sapiens	38-41
17211247-4	2007	METHODS AND RESULTS: Angiotensin II infused intracisternally for 7 days in Wistar-Kyoto rats (WKY) increased systolic blood pressure (SBP) and urinary norepinephrine excretion.	Norepinephrine	151-165	angiotensinogen	Rattus norvegicus	21-35
17074321-8	2007	Decreased expression of DBH with age in the retina could lead to reduced production of norepinephrine, potentially resulting in an increase of beta1-adrenergic receptor expression due to denervation supersensitivity.	Norepinephrine	87-101	adrenoceptor beta 1	Rattus norvegicus	143-168
17196760-8	2007	Finally, preliminary results suggest that CART directly controls the expression of major neurotransmitters such as serotonin, noradrenaline, and dopamine.	Norepinephrine	126-139	CART prepropeptide	Homo sapiens	42-46
17256449-1	2007	OBJECTIVES: The noradrenaline-selective antidepressant reboxetine in vitro is a weak inhibitor of both cytochrome P450 (CYP) 2D6 and CYP3A4.	Norepinephrine	16-29	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	103-128
17256449-1	2007	OBJECTIVES: The noradrenaline-selective antidepressant reboxetine in vitro is a weak inhibitor of both cytochrome P450 (CYP) 2D6 and CYP3A4.	Norepinephrine	16-29	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	133-139
18265860-2	2007	In this study we evaluated the association of AVP with organ failure and mortality in cardiac surgical patients suffering from vasodilatory shock refractory to norepinephrine (NE) treatment.	Norepinephrine	160-174	arginine vasopressin	Homo sapiens	46-49
17765726-10	2007	Norepinephrine also promotes frequency-induced potentiation of granule cell output at the mossy fiber to CA3 connection.	Norepinephrine	0-14	carbonic anhydrase 3	Homo sapiens	105-108
17054915-1	2006	Tyrosine hydroxylase (tyrosine 3-monooxygenase, EC 1.14.16.2, TH) is the rate-limiting enzyme in the biosynthesis of catecholamine neurotransmitters, dopamine (DA), noradrenaline (NE), and adrenaline, in the neurons.	Norepinephrine	165-178	tyrosine hydroxylase	Homo sapiens	0-20
17070516-10	2006	Norepinephrine-induced RhoA attenuation, through cAMP/protein kinase A (PKA) activation coupled with beta-adrenoceptors, may lead to eNOS activation in acute conditions.	Norepinephrine	0-14	ras homolog family member A	Homo sapiens	23-27
17070516-11	2006	Norepinephrine stimulates the production of VEGF mRNA through cAMP/PKA activation coupled with beta-adrenoceptors.	Norepinephrine	0-14	vascular endothelial growth factor A	Homo sapiens	44-48
17070516-12	2006	Norepinephrine stimulates a mitogenic effect through ERK activation coupled with the alpha(1)-adrenoceptor.	Norepinephrine	0-14	mitogen-activated protein kinase 1	Homo sapiens	53-56
17070516-13	2006	In conclusion, norepinephrine stimulates eNOS activity via RhoA attenuation, VEGF mRNA synthesis and mitogenic activity in endothelial cells.	Norepinephrine	15-29	ras homolog family member A	Homo sapiens	59-63
17070516-13	2006	In conclusion, norepinephrine stimulates eNOS activity via RhoA attenuation, VEGF mRNA synthesis and mitogenic activity in endothelial cells.	Norepinephrine	15-29	vascular endothelial growth factor A	Homo sapiens	77-81
17070516-8	2006	Thus, it is reasonable to speculate that norepinephrine may stimulate the level of VEGF mRNA.	Norepinephrine	41-55	vascular endothelial growth factor A	Homo sapiens	83-87
17054915-1	2006	Tyrosine hydroxylase (tyrosine 3-monooxygenase, EC 1.14.16.2, TH) is the rate-limiting enzyme in the biosynthesis of catecholamine neurotransmitters, dopamine (DA), noradrenaline (NE), and adrenaline, in the neurons.	Norepinephrine	165-178	tyrosine hydroxylase	Homo sapiens	22-46
16949803-9	2006	The maximal contraction generated by the alpha-agonists phenylephrine or noradrenaline (10 microM) was significantly enhanced in JNK2+3 knockout arteries compared with arteries from the remaining strains.	Norepinephrine	73-86	mitogen-activated protein kinase 9	Mus musculus	129-133
16959848-4	2006	The endogenous adrenergic neurotransmitter norepinephrine induced a potent increase in GLUT1 mRNA and a decrease of GLUT4 mRNA in mature brown adipocytes.	Norepinephrine	43-57	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	116-121
16949803-10	2006	Inhibition of NOS by Nw-nitro-l-arginine did not change the pattern of vasoconstriction, but vasoconstriction by noradrenaline following NOS inhibition was significantly enhanced in the arteries from JNK2+3 double knockout mice.	Norepinephrine	113-126	mitogen-activated protein kinase 9	Mus musculus	200-204
17378376-12	2006	The over-expression of MT in H9c2 cells inhibited norepinephrine-induced apoptosis, suggesting that MT may act as an anti-apoptotic molecule in cardiac hypertrophy.	Norepinephrine	50-64	metallothionein 1	Rattus norvegicus	23-25
17205149-5	2006	Factors such as leptin inducible factors (for example, noradrenaline), that regulate the activity of profibrogenic cytokines, such as IL-10 and TGF-beta, dictate the extent of fibrosis that occurs during liver injury.	Norepinephrine	55-68	transforming growth factor beta 1	Homo sapiens	144-152
16959848-11	2006	Norepinephrine treatment shifted GLUT4 from the PM to an intracellular vesicular compartment.	Norepinephrine	0-14	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	33-38
16835395-4	2006	Epididymal tissue from wild-type mice responded in vitro to noradrenaline and isoprenaline with increased glycerol release, reduced IL-6 release, and increased cAMP accumulation.	Norepinephrine	60-73	interleukin 6	Mus musculus	132-136
17082723-5	2006	Resting norepinephrine predicted fibrinogen (beta = 0.42, P < 0.01) and D-dimer (beta = 0.37, P < 0.03), both independent of MBP.	Norepinephrine	8-22	fibrinogen beta chain	Homo sapiens	33-43
16941481-6	2006	The concomitant administration of desipramine (DMI), a specific noradrenaline uptake inhibitor, fully prevented the RIS-induced increase in CRH expression.	Norepinephrine	64-77	corticotropin releasing hormone	Rattus norvegicus	140-143
16798826-9	2006	Norepinephrine-induced growth in hypoxic PA was dose dependent, had efficacy greater than or equal to endothelin-1, required the presence of wall tension, and was inhibited by alpha(1A)-AR antagonist.	Norepinephrine	0-14	endothelin 1	Rattus norvegicus	102-114
17041759-1	2006	Our previous study demonstrated that norepinephrine (NE) induces endothelial apoptosis mainly through down-regulation of Bcl-2 protein and activation of the beta-adrenergic and caspase-2 pathways.	Norepinephrine	37-51	BCL2, apoptosis regulator	Rattus norvegicus	121-126
17079456-0	2006	Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells.	Norepinephrine	0-14	vascular endothelial growth factor A	Homo sapiens	46-80
17079456-1	2006	Recent studies using ovarian cancer cells have shown that the catecholamine hormones norepinephrine (norepi) and epinephrine (epi) may influence cancer progression by modulating the expression of matrix metalloproteinases (MMP) and vascular endothelial growth factor (VEGF).	Norepinephrine	85-99	vascular endothelial growth factor A	Homo sapiens	232-266
17079456-1	2006	Recent studies using ovarian cancer cells have shown that the catecholamine hormones norepinephrine (norepi) and epinephrine (epi) may influence cancer progression by modulating the expression of matrix metalloproteinases (MMP) and vascular endothelial growth factor (VEGF).	Norepinephrine	85-99	vascular endothelial growth factor A	Homo sapiens	268-272
17079456-1	2006	Recent studies using ovarian cancer cells have shown that the catecholamine hormones norepinephrine (norepi) and epinephrine (epi) may influence cancer progression by modulating the expression of matrix metalloproteinases (MMP) and vascular endothelial growth factor (VEGF).	Norepinephrine	85-91	vascular endothelial growth factor A	Homo sapiens	232-266
17079456-1	2006	Recent studies using ovarian cancer cells have shown that the catecholamine hormones norepinephrine (norepi) and epinephrine (epi) may influence cancer progression by modulating the expression of matrix metalloproteinases (MMP) and vascular endothelial growth factor (VEGF).	Norepinephrine	85-91	vascular endothelial growth factor A	Homo sapiens	268-272
17079456-2	2006	The purpose of this study is to determine if the stress hormone norepi can influence the expression of MMP-2, MMP-9, and VEGF in nasopharyngeal carcinoma (NPC) tumors by using three NPC tumor cell lines.	Norepinephrine	64-70	vascular endothelial growth factor A	Homo sapiens	121-125
17100837-0	2006	Corticotropin-releasing factor promotes growth of brain norepinephrine neuronal processes through Rho GTPase regulators of the actin cytoskeleton in rat.	Norepinephrine	56-70	corticotropin releasing hormone	Rattus norvegicus	0-30
17100837-1	2006	Cognitive aspects of the acute stress response are partly mediated through activation of the locus coeruleus (LC)-norepinephrine (NE) system via corticotropin-releasing factor (CRF).	Norepinephrine	114-128	corticotropin releasing hormone	Rattus norvegicus	145-175
17130675-11	2006	Our results indicated that endothelin-1 plays a key role in the FK506-induced change in vascular reactivity to noradrenaline in renal vascular beds and drug-induced hypertension in the rats.	Norepinephrine	111-124	endothelin 1	Rattus norvegicus	27-39
16962210-1	2006	The influence of alpha2-autoreceptors on the facilitation of [3H]-noradrenaline release mediated by angiotensin II was studied in prostatic portions of rat vas deferens preincubated with [3H]-noradrenaline.	Norepinephrine	66-79	angiotensinogen	Rattus norvegicus	100-114
16788141-11	2006	We conclude that decreases in UT-A1, AQP2, and NKCC2/BSC1 proteins may contribute to the diuresis and natriuresis that occur following ANG II or norepinephrine-induced acute hypertension and do not appear to involve ANG II stimulation of aldosterone or thirst.	Norepinephrine	145-159	angiotensinogen	Rattus norvegicus	216-222
17151983-4	2006	In such advanced, catecholamine-resistant shock states, arginine-vasopressin (AVP) has repeatedly caused an increase in mean arterial blood pressure, a decrease in toxic norepinephrine-dosages, as well as further beneficial hemodynamic, endocrinologic and renal effects.	Norepinephrine	170-184	arginine vasopressin	Homo sapiens	65-76
17090215-8	2006	The thermogenic role of PGC-1beta was identified in thermoneutral and cold-adapted conditions by inadequate responses to norepinephrine injection.	Norepinephrine	121-135	peroxisome proliferative activated receptor, gamma, coactivator 1 beta	Mus musculus	24-33
17053072-1	2006	During the fight-or-flight response, epinephrine and norepinephrine released by the sympathetic nervous system increase L-type calcium currents conducted by Ca(V)1.2a channels in the heart, which contributes to enhanced cardiac performance.	Norepinephrine	53-67	caveolin 1	Rattus norvegicus	157-163
17012525-0	2006	Hostility and urine norepinephrine interact to predict insulin resistance: the VA Normative Aging Study.	Norepinephrine	20-34	insulin	Homo sapiens	55-62
16741674-16	2006	All three treatments resulted in significant increase of SOD activity, but norepinephrine was the most effective.	Norepinephrine	75-89	superoxide dismutase 1	Rattus norvegicus	57-60
16741674-20	2006	As in the case of SOD, the highest levels of CAT activity were induced by norepinephrine, while lower but significant increase in CAT activity was induced by 3-nitropropionic acid.5.	Norepinephrine	74-88	superoxide dismutase 1	Rattus norvegicus	18-21
16741674-20	2006	As in the case of SOD, the highest levels of CAT activity were induced by norepinephrine, while lower but significant increase in CAT activity was induced by 3-nitropropionic acid.5.	Norepinephrine	74-88	catalase	Rattus norvegicus	45-48
16838359-2	2006	Dopamine-beta-hydroxylase (DBH) is the key enzyme in the conversion of dopamine to norepinephrine and the alleles of several polymorphisms of the DBH gene are correlated with individual variation in serum levels of the enzyme.	Norepinephrine	83-97	dopamine beta-hydroxylase	Meleagris gallopavo	0-25
16838359-2	2006	Dopamine-beta-hydroxylase (DBH) is the key enzyme in the conversion of dopamine to norepinephrine and the alleles of several polymorphisms of the DBH gene are correlated with individual variation in serum levels of the enzyme.	Norepinephrine	83-97	dopamine beta-hydroxylase	Meleagris gallopavo	27-30
16838359-2	2006	Dopamine-beta-hydroxylase (DBH) is the key enzyme in the conversion of dopamine to norepinephrine and the alleles of several polymorphisms of the DBH gene are correlated with individual variation in serum levels of the enzyme.	Norepinephrine	83-97	dopamine beta-hydroxylase	Meleagris gallopavo	146-149
16854392-1	2006	The biosynthesis of norepinephrine occurs through a multi-enzymatic pathway that includes the enzyme dopamine-beta-hydroxylase (DBH).	Norepinephrine	20-34	dopamine beta hydroxylase	Mus musculus	101-126
16854392-1	2006	The biosynthesis of norepinephrine occurs through a multi-enzymatic pathway that includes the enzyme dopamine-beta-hydroxylase (DBH).	Norepinephrine	20-34	dopamine beta hydroxylase	Mus musculus	128-131
16854392-2	2006	Mice with a homozygous deletion of DBH (Dbh-/-) have a selective and complete absence of norepinephrine.	Norepinephrine	89-103	dopamine beta hydroxylase	Mus musculus	35-38
16854392-2	2006	Mice with a homozygous deletion of DBH (Dbh-/-) have a selective and complete absence of norepinephrine.	Norepinephrine	89-103	dopamine beta hydroxylase	Mus musculus	40-47
17012525-3	2006	We hypothesized that hostility may interact with circulating norepinephrine (NEPI) levels, indexed by 24-hour urine concentrations, to affect insulin resistance.	Norepinephrine	61-75	insulin	Homo sapiens	142-149
17012525-3	2006	We hypothesized that hostility may interact with circulating norepinephrine (NEPI) levels, indexed by 24-hour urine concentrations, to affect insulin resistance.	Norepinephrine	77-81	insulin	Homo sapiens	142-149
16643958-2	2006	Phenylethanolamine-N-methyltransferase, the enzyme catalyzing the conversion of norepinephrine into epinephrine, was not detected in either Mk -/- and WT (+/+) mouse aorta.	Norepinephrine	80-94	phenylethanolamine-N-methyltransferase	Mus musculus	0-38
16820514-4	2006	Additional studies using serum-free media suggested that transferrin plays a role in norepinephrine-induced growth.	Norepinephrine	85-99	transferrin	Homo sapiens	57-68
17111027-1	2006	Increased vasoconstrictor response to norepinephrine (NE) and endothelin (ET)-1 in arteries from diabetic animals is ameliorated by chronic endothelin receptor blockade with bosentan and was absent in endothelium-denuded arteries, suggesting the involvement of ET-1 and an endothelium-derived contracting factor such as thromboxane A2 (TxA2).	Norepinephrine	38-52	endothelin 1	Rattus norvegicus	261-265
16842616-11	2006	Contractile activity induced by norepinephrin after tamsulosin incubation in rat prostatic vas deferens strips is similar to the contractile activity evoked by norepinephrin in human strips.	Norepinephrine	32-45	arginine vasopressin	Rattus norvegicus	91-94
16287213-2	2006	The vasoconstrictor response induced by norepinephrine (NE), endothelin-1 (ET-1) or angiotensin II (Ang II) was significantly increased whereas vasodilator response to carbachol, histamine or sodium nitroprusside (SNP) was not altered in the renal artery segments of the streptozotocin (STZ)-diabetic rats.	Norepinephrine	40-54	angiotensinogen	Rattus norvegicus	100-106
16650497-9	2006	The results show that TH and AGT mRNA expression changes during the different phases of experimental hypertension, suggesting that the noradrenaline (NOR) and angiotensin II (Ang II) might participate in the modulation/maintenance of coarctation hypertension.	Norepinephrine	135-148	angiotensinogen	Rattus norvegicus	29-32
16636898-8	2006	Radioligand binding to the dopamine (DAT), norepinephrine (NET), and serotonin (SERT) transporters is inhibited with k (i) values of 222, 1030, and 740 nM, respectively.	Norepinephrine	43-57	solute carrier family 6 member 4	Rattus norvegicus	80-84
16810071-1	2006	The effect of neuropeptide Y (NPY) on the basal and nerve stimulation-induced increase in norepinephrine synthesis was studied in the isolated and perfused mesenteric arterial bed of the rat.	Norepinephrine	90-104	neuropeptide Y	Rattus norvegicus	14-28
16786106-1	2006	Neuropeptide Y (NPY) co-exists with norepinephrine (NE) in sympathetic terminals, and is the most abundant neuropeptide in myocardium.	Norepinephrine	36-50	neuropeptide Y	Rattus norvegicus	0-14
16786106-1	2006	Neuropeptide Y (NPY) co-exists with norepinephrine (NE) in sympathetic terminals, and is the most abundant neuropeptide in myocardium.	Norepinephrine	36-50	neuropeptide Y	Rattus norvegicus	16-19
16644734-1	2006	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline, and adrenaline.	Norepinephrine	106-119	tyrosine hydroxylase	Homo sapiens	0-20
16644734-1	2006	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline, and adrenaline.	Norepinephrine	106-119	tyrosine hydroxylase	Homo sapiens	22-24
16819988-1	2006	Corticotropin-releasing factor (CRF) acts within the locus coeruleus (LC), to modulate activity of the LC-norepinephrine (NE) system.	Norepinephrine	106-120	corticotropin releasing hormone	Rattus norvegicus	0-30
16810071-1	2006	The effect of neuropeptide Y (NPY) on the basal and nerve stimulation-induced increase in norepinephrine synthesis was studied in the isolated and perfused mesenteric arterial bed of the rat.	Norepinephrine	90-104	neuropeptide Y	Rattus norvegicus	30-33
16764338-3	2006	At baseline, the norepinephrine level was significantly decreased (P =0.003) in the long-term IFN MS patients compared with the controls.	Norepinephrine	17-31	interferon alpha 1	Homo sapiens	94-97
16677282-10	2006	Norepinephrine elevated C/EBPalpha DNA binding activity, but cortisol did not increase the activity.	Norepinephrine	0-14	CCAAT enhancer binding protein alpha	Homo sapiens	24-34
16764338-6	2006	The lower norepinephrine level at baseline in the long-term IFN MS group suggests an immunologically stable phase, in line with our previous findings.	Norepinephrine	10-24	interferon alpha 1	Homo sapiens	60-63
16612252-8	2006	We also stimulated norepinephrine secretion by other chromaffin cell agonists: catestatin blocked norepinephrine release induced by nicotine, but not by other agents (such as membrane depolarization) acting at later stages in the secretory pathway, nor by agents acting on other receptor classes.	Norepinephrine	19-33	chromogranin A	Homo sapiens	79-89
16771677-1	2006	The neurotransmitter noradrenaline (NA) exerts important antiinflammatory effects on glial cells including suppression of the inducible form of nitric oxide synthase (NOS2).	Norepinephrine	21-34	nitric oxide synthase 2	Rattus norvegicus	167-171
16771678-0	2006	Effects of noradrenaline on neuronal NOS2 expression and viability.	Norepinephrine	11-24	nitric oxide synthase 2, inducible	Mus musculus	37-41
16771678-2	2006	Here they examined the ability of noradrenaline (NA) to reduce neuronal NOS2 or cell death.	Norepinephrine	34-47	nitric oxide synthase 2, inducible	Mus musculus	72-76
16718754-9	2006	Other neurotransmitters such as serotonin and noradrenaline may be implicated with CCK in the coordination of GI activity.	Norepinephrine	46-59	cholecystokinin	Homo sapiens	83-86
16715917-7	2006	Blood pressure finally returned towards baseline after infusion of norepinephrine 0.2 microg x kg(-1) x min(-1) and epinephrine 0.1 microg x kg(-1) x min(-1).	Norepinephrine	67-81	CD59 molecule (CD59 blood group)	Homo sapiens	104-110
16612252-8	2006	We also stimulated norepinephrine secretion by other chromaffin cell agonists: catestatin blocked norepinephrine release induced by nicotine, but not by other agents (such as membrane depolarization) acting at later stages in the secretory pathway, nor by agents acting on other receptor classes.	Norepinephrine	98-112	chromogranin A	Homo sapiens	79-89
16532389-6	2006	Here, we report that mice deficient in the Spr gene (Spr(-/-)) display disturbed pterin profiles and greatly diminished levels of dopamine, norepinephrine, and serotonin, indicating that SPR is essential for homeostasis of BH(4) and for the normal functions of BH(4)-dependent enzymes.	Norepinephrine	140-154	sepiapterin reductase	Mus musculus	43-46
16284232-1	2006	It has long been proposed that the renin-angiotensin system exerts a stimulatory influence on the sympathetic nervous system, including augmentation of central sympathetic outflow and presynaptic facilitation of norepinephrine release from sympathetic nerves.	Norepinephrine	212-226	renin	Homo sapiens	35-40
16507050-6	2006	The actions of several factors beside noradrenaline (e.g. endothelin-1, angiotensin II), possibly involved in the increased smooth muscle activity found in both LUTS/BPH and sexual dysfunction, are dependent on Rho-kinase activity.	Norepinephrine	38-51	endothelin 1	Homo sapiens	58-70
16507050-6	2006	The actions of several factors beside noradrenaline (e.g. endothelin-1, angiotensin II), possibly involved in the increased smooth muscle activity found in both LUTS/BPH and sexual dysfunction, are dependent on Rho-kinase activity.	Norepinephrine	38-51	angiotensinogen	Homo sapiens	72-86
16609702-9	2006	Finally, norepinephrine, isoproterenol, CL316243, and palmitate inhibited the effects of insulin, L-leucine, and L-glutamate on leptin synthesis.	Norepinephrine	9-23	insulin	Homo sapiens	89-96
16611095-1	2006	Galanin is a neuropeptide synthesized in many neuronal types including brainstem norepinephrine-producing cells of the locus coeruleus and the serotonin-producing neurons of the dorsal raphe nucleus.	Norepinephrine	81-95	galanin and GMAP prepropeptide	Mus musculus	0-7
16611095-2	2006	Galanin inhibits the firing of rodent norepinephrine, serotonin and dopamine neurons and reduces release of these neurotransmitters in forebrain target regions.	Norepinephrine	38-52	galanin and GMAP prepropeptide	Mus musculus	0-7
16539676-1	2006	For many years, the norepinephrine transporter (NET) was considered a "static" protein that contributed to the termination of the action of norepinephrine in the synapse of noradrenergic neurons.	Norepinephrine	20-34	solute carrier family 6 member 2	Homo sapiens	48-51
16386803-0	2006	The involvement of norepinephrine and microglia in hypothalamic and splenic IL-1beta responses to stress.	Norepinephrine	19-33	interleukin 1 beta	Rattus norvegicus	76-84
16386803-3	2006	One goal of the following studies was to assess the role of norepinephrine in stress-elicited increases in IL-1beta.	Norepinephrine	60-74	interleukin 1 beta	Rattus norvegicus	107-115
16484914-10	2006	Low-dose vasopressin significantly increased the responsiveness to norepinephrine (EC50 = 0.5 microM) just as a low-dose norepinephrine significantly enhanced the vasopressin response (EC(50) = 2.3 nM).	Norepinephrine	67-81	arginine vasopressin	Homo sapiens	9-20
16484914-10	2006	Low-dose vasopressin significantly increased the responsiveness to norepinephrine (EC50 = 0.5 microM) just as a low-dose norepinephrine significantly enhanced the vasopressin response (EC(50) = 2.3 nM).	Norepinephrine	121-135	arginine vasopressin	Homo sapiens	163-174
16503921-1	2006	ATP and norepinephrine are neurotransmitters carrying cardiovascular information to vasopressin (AVP) neurones.	Norepinephrine	8-22	arginine vasopressin	Homo sapiens	84-95
16515684-2	2006	The transporters for the monoamines dopamine, norepinephrine, and serotonin (DAT, NET, and SERT) are targets for several popular psychostimulant drugs of abuse.	Norepinephrine	46-60	solute carrier family 6 member 2	Homo sapiens	82-85
16510160-3	2006	The sympathetic fibers were visualized by the immunofluorescent labeling of the noradrenaline synthesizing enzymes tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH).	Norepinephrine	80-93	dopamine beta-hydroxylase	Oryctolagus cuniculus	172-175
16570552-5	2006	Vasopressin should be considered if hypotension persists or if the situation requires escalating doses of norepinephrine.	Norepinephrine	106-120	arginine vasopressin	Homo sapiens	0-11
16188498-2	2006	The function of the beta1- and the alpha2C-adrenergic receptors is influenced by gene polymorphisms: the beta1Arg389 variant is associated with increased beta1-receptor sensitivity and the alpha2C-receptor Del322-325 variant is associated with decreased alpha2C receptor function and increased norepinephrine release.	Norepinephrine	294-308	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	20-25
16188498-2	2006	The function of the beta1- and the alpha2C-adrenergic receptors is influenced by gene polymorphisms: the beta1Arg389 variant is associated with increased beta1-receptor sensitivity and the alpha2C-receptor Del322-325 variant is associated with decreased alpha2C receptor function and increased norepinephrine release.	Norepinephrine	294-308	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	105-110
16352648-4	2006	Cultured neonatal rat cardiomyocytes were exposed for 24 h to increasing concentrations of noradrenaline (1-10000 nM) (physiological agonist at alpha and beta-adrenoceptors), resulting in significantly increased Cx43-expression, while Cx40 was unaffected.	Norepinephrine	91-104	gap junction protein, alpha 1	Rattus norvegicus	212-216
16123744-0	2006	Sexually dimorphic responses of the brain norepinephrine system to stress and corticotropin-releasing factor.	Norepinephrine	42-56	corticotropin releasing hormone	Rattus norvegicus	78-108
16412264-6	2006	However, relative to the normal saline group, in the norepinephrine-treated hearts, heart function, and myocardial ultrastructure deteriorated significantly, apoptosis and amount of Bax product increased significantly, and the ATP, phosphocreatine, and glycogen content decreased significantly, as did the amount of Bcl-2 product.	Norepinephrine	53-67	BCL2, apoptosis regulator	Rattus norvegicus	316-321
16424707-12	2006	Norepinephrine doses required to achieve the hemodynamic targets were lower in GW274150 (p < .001 vs. controls) and even further reduced in iNOS-/- mice (p < .001 vs. controls, p < .001 vs. GW274150).	Norepinephrine	0-14	nitric oxide synthase 2, inducible	Mus musculus	143-147
16424707-16	2006	Genetic iNOS deletion and pharmacologic iNOS blockade enhanced cardiac norepinephrine responsiveness due to improved systolic function.	Norepinephrine	71-85	nitric oxide synthase 2, inducible	Mus musculus	8-12
16424707-16	2006	Genetic iNOS deletion and pharmacologic iNOS blockade enhanced cardiac norepinephrine responsiveness due to improved systolic function.	Norepinephrine	71-85	nitric oxide synthase 2, inducible	Mus musculus	40-44
16513451-3	2006	We studied the influence of this polymorphism on the responses to angiotensin II antagonism in the presence of ET-1, norepinephrine, and angiotensin II.	Norepinephrine	117-131	angiotensinogen	Homo sapiens	66-80
16352648-4	2006	Cultured neonatal rat cardiomyocytes were exposed for 24 h to increasing concentrations of noradrenaline (1-10000 nM) (physiological agonist at alpha and beta-adrenoceptors), resulting in significantly increased Cx43-expression, while Cx40 was unaffected.	Norepinephrine	91-104	gap junction protein, alpha 5	Rattus norvegicus	235-239
16234247-6	2006	Established inhibitors of NAPDH production via the pentose pathway (dehydroandrostenedione or norepinephrine) inhibited 11 beta-HSD1 oxo-reductase while decreasing cellular NADPH content.	Norepinephrine	94-108	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	120-132
16303838-8	2006	RESULTS: Plasma epinephrine increased 10-fold and plasma norepinephrine 2-fold in response to insulin-induced hypoglycemia.	Norepinephrine	57-71	insulin	Homo sapiens	94-101
16417582-1	2006	The norepinephrine transporter (NET) is responsible for the rapid removal of norepinephrine released from sympathetic neurons; this release is controlled by inhibitory alpha(2)-adrenergic receptors (alpha(2)ARs).	Norepinephrine	4-18	adrenergic receptor, alpha 2a	Mus musculus	199-210
16489848-7	2006	Use of vasopressin in vasodilatory shock should be guided by strict hemodynamic indications, such as hypotension despite norepinephrine (noradrenaline) dosages >0.5 mug/kg/min.	Norepinephrine	121-135	arginine vasopressin	Homo sapiens	7-18
16489848-7	2006	Use of vasopressin in vasodilatory shock should be guided by strict hemodynamic indications, such as hypotension despite norepinephrine (noradrenaline) dosages >0.5 mug/kg/min.	Norepinephrine	137-150	arginine vasopressin	Homo sapiens	7-18
16489848-10	2006	When norepinephrine dosages decrease to 0.2 microg/kg/min, vasopressin is withdrawn in small steps according to the response in mean arterial pressure.	Norepinephrine	5-19	arginine vasopressin	Homo sapiens	59-70
16331293-9	2006	When (-)-noradrenaline interacts with the beta(1)-adrenoceptor, the generated cyclic AMP is hydrolysed only by PDE4, thereby reducing cardiostimulation.	Norepinephrine	5-22	adrenoceptor beta 1	Rattus norvegicus	42-62
16225854-2	2006	METHODS: The positive inotropic effects of noradrenaline (in the presence of the beta2-selective antagonist ICI118551) and adrenaline (in the presence of the beta1-selective antagonist CGP20712), mediated through beta1- and beta2-adrenoceptors, respectively, were investigated in atrial and ventricular trabeculae.	Norepinephrine	43-56	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	213-218
17073682-3	2006	The fact that all three monoamine (dopamine, norepinephrine, and serotonin) transporters (DAT, NET and SERT) are involved in various neurological and psychiatric diseases further emphasizes the need to develop suitable NET ligands so that researchers will be able to probe the contributions of each monoamine transporter system to specific CNS disorders.	Norepinephrine	45-59	solute carrier family 6 member 2	Homo sapiens	219-222
16989291-3	2006	For the majority of antidepressants, these changes are the result of their ability to block serotonin and/or norepinephrine activity at their "presynaptic uptake sites" (i.e., at the serotonin transporter [SERT] or the norepinephrine transporter [NET]).	Norepinephrine	109-123	solute carrier family 6 member 4	Homo sapiens	183-204
16989291-3	2006	For the majority of antidepressants, these changes are the result of their ability to block serotonin and/or norepinephrine activity at their "presynaptic uptake sites" (i.e., at the serotonin transporter [SERT] or the norepinephrine transporter [NET]).	Norepinephrine	109-123	solute carrier family 6 member 4	Homo sapiens	206-210
16989291-3	2006	For the majority of antidepressants, these changes are the result of their ability to block serotonin and/or norepinephrine activity at their "presynaptic uptake sites" (i.e., at the serotonin transporter [SERT] or the norepinephrine transporter [NET]).	Norepinephrine	109-123	solute carrier family 6 member 2	Homo sapiens	219-245
16722229-3	2006	Cotransport in norepinephrine (NET), epinephrine (EpiT), dopamine (DAT), and serotonin (SERT) transporters couples downhill Na+ flux to uphill transmitter flux.	Norepinephrine	15-29	solute carrier family 6 member 4	Homo sapiens	77-86
16722229-3	2006	Cotransport in norepinephrine (NET), epinephrine (EpiT), dopamine (DAT), and serotonin (SERT) transporters couples downhill Na+ flux to uphill transmitter flux.	Norepinephrine	15-29	solute carrier family 6 member 4	Homo sapiens	88-92
16722235-11	2006	The TEs of OCT1 and OCT2 for dopamine, noradrenaline, adrenaline and 5-HT in general are rather low, in the range relative to MPP+ of 5%-15%.	Norepinephrine	39-52	POU class 2 homeobox 2	Rattus norvegicus	20-24
16722247-1	2006	The norepinephrine transporter (NET) terminates noradrenergic signalling by rapid re-uptake of neuronally released norepinephrine (NE) into presynaptic terminals.	Norepinephrine	4-18	solute carrier family 6 member 2	Homo sapiens	32-35
17017570-1	2006	In the 1950s it was found that an artificial aminoacid, 3,4-threo-dihydroxyphenylserine (DOPS), was converted to norepinephrine (NE) in a single step by the enzyme L-aromatic amino acid decarboxylase (AADC), bypassing the need for the rate limiting enzyme dopamine beta hydroxylase.	Norepinephrine	113-127	dopa decarboxylase	Homo sapiens	201-205
16863269-8	2006	In this context, galanin is of particular interest, since it is co-localised with serotonin in the dorsal raphe nucleus and with noradrenaline in the locus coeruleus, nuclei known to play a major role in affective disorders and in the action of antidepressant drugs.	Norepinephrine	129-142	galanin and GMAP prepropeptide	Mus musculus	17-24
17124432-1	2006	BACKGROUND: Norepinephrine transporter (NET) is involved in the regulation of norepinephrine (NE) turnover and metabolism.	Norepinephrine	78-92	solute carrier family 6 member 2	Homo sapiens	12-38
17124432-1	2006	BACKGROUND: Norepinephrine transporter (NET) is involved in the regulation of norepinephrine (NE) turnover and metabolism.	Norepinephrine	78-92	solute carrier family 6 member 2	Homo sapiens	40-43
16449406-8	2006	Noradrenaline and adrenaline plasma clearance and plasma tritiated noradrenaline and adrenaline extraction in transit through the heart, all dependent on the noradrenaline transporter (NET), were reduced in PD.	Norepinephrine	0-13	solute carrier family 6 member 2	Homo sapiens	158-183
16298239-0	2006	Insulin effects on CSF norepinephrine and cognition in Alzheimer"s disease.	Norepinephrine	23-37	insulin	Homo sapiens	0-7
17167239-11	2006	According to this, the excessive release of noradrenaline from these nerves should provoke an enhancement of glucagon secretion which will result in overexcitation of insulin secretion from B cells.	Norepinephrine	44-57	insulin	Homo sapiens	167-174
16449406-8	2006	Noradrenaline and adrenaline plasma clearance and plasma tritiated noradrenaline and adrenaline extraction in transit through the heart, all dependent on the noradrenaline transporter (NET), were reduced in PD.	Norepinephrine	0-13	solute carrier family 6 member 2	Homo sapiens	185-188
16307583-3	2005	Here we investigated the role of the Ret gene, which encodes a transmembrane tyrosine kinase receptor, in the maturation of norepinephrine and respiratory systems.	Norepinephrine	124-138	ret proto-oncogene	Mus musculus	37-40
16219387-1	2005	Multiple intracellular and extracellular regulatory factors affect transcription of the tyrosine hydroxylase (TH) gene encoding the rate-limiting enzyme in the biosynthesis of the neurotransmitters dopamine, norepinephrine and epinephrine.	Norepinephrine	208-222	tyrosine hydroxylase	Homo sapiens	88-108
16219387-1	2005	Multiple intracellular and extracellular regulatory factors affect transcription of the tyrosine hydroxylase (TH) gene encoding the rate-limiting enzyme in the biosynthesis of the neurotransmitters dopamine, norepinephrine and epinephrine.	Norepinephrine	208-222	tyrosine hydroxylase	Homo sapiens	110-112
16183639-5	2005	Added singly, dopamine gives slight, and norepinephrine a more significant, activation of ERK and S6K; both catecholeamines, however, enhance glutamatergic activation of S6K but not ERK.	Norepinephrine	41-55	mitogen-activated protein kinase 1	Mus musculus	90-93
16307583-6	2005	Second, in Ret-/- fetuses, high-pressure liquid chromatography showed significantly reduced norepinephrine contents in the pons but not the medulla.	Norepinephrine	92-106	ret proto-oncogene	Mus musculus	11-14
16307583-8	2005	Finally, electrophysiological and pharmacological experiments performed on brainstem "en bloc" preparations demonstrated impaired resting respiratory activity and abnormal responses to central hypoxia and norepinephrine application in Ret-/- fetuses.	Norepinephrine	205-219	ret proto-oncogene	Mus musculus	235-238
16408644-0	2005	[Influence of carbachol on the kinetic parameters of the contractile response to noradrenaline in the rat vas deferens].	Norepinephrine	81-94	arginine vasopressin	Rattus norvegicus	106-109
16268952-12	2005	Insulin injection increased plasma catecholamines on the average by 21.5% and 53.4% for adrenaline and noradrenaline respectively.	Norepinephrine	103-116	insulin	Gallus gallus	0-7
16163519-1	2005	RATIONALE: Dopamine beta-hydroxylase (DBH) converts dopamine (DA) to norepinephrine (NE), thus playing a critical role in catecholamine metabolism.	Norepinephrine	69-83	dopamine beta hydroxylase	Mus musculus	11-36
16163519-1	2005	RATIONALE: Dopamine beta-hydroxylase (DBH) converts dopamine (DA) to norepinephrine (NE), thus playing a critical role in catecholamine metabolism.	Norepinephrine	69-83	dopamine beta hydroxylase	Mus musculus	38-41
16408644-1	2005	Graphic and mathematical analysis of kinetics of the rat vas deferens contractile response to noradrenaline showed that alpha1-adrenoceptors mediating the contraction were in different functional states.	Norepinephrine	94-107	arginine vasopressin	Rattus norvegicus	57-60
15914506-10	2005	Both epinephrine and norepinephrine reduced insulin-stimulated GLUT4 translocation to the plasma membrane.	Norepinephrine	21-35	insulin	Homo sapiens	44-51
16085362-6	2005	SB-334867 concentration-dependently inhibited orexin A-evoked norepinephrine release with pIC50 (Imax) of 6.05+/-0.14 (86.4+/-5.4%); clonidine (alpha2-agonist) was ineffective.	Norepinephrine	62-76	hypocretin neuropeptide precursor	Rattus norvegicus	46-54
16182977-0	2005	Low plasma vasopressin/norepinephrine ratio predicts septic shock.	Norepinephrine	23-37	arginine vasopressin	Homo sapiens	11-22
16182977-5	2005	The plasma vasopressin level at baseline was significantly lower for those who finally developed septic shock (septic shock group, 3.6 +/- 2.5 pg/mL; 95% confidence interval [CI], 3.0-4.2 pg/mL; severe sepsis group, 21.8 +/- 4.1 pg/mL, 95% CI, 20.7-22.9 pg/mL; sepsis group, 10.6 +/- 6.5 pg/mL, 95% CI, 8.8-12.4 pg/mL, P < .001), whereas the norepinephrine level was highest for the same group (septic shock group, 3650 +/- 980 pg/mL, 95% CI, 3420-3880 pg/mL; severe sepsis group, 3600 +/- 1000 pg/mL, 95% CI, 3330-3870 pg/mL; sepsis group, 1720 +/- 320 pg/mL, 95% CI, 1630-1810 pg/mL).	Norepinephrine	345-359	arginine vasopressin	Homo sapiens	11-22
16182977-6	2005	The vasopressin/norepinephrine ratio was significantly lower for the patients with final diagnosis of septic shock (P < .001).	Norepinephrine	16-30	arginine vasopressin	Homo sapiens	4-15
16182977-8	2005	Receiver operating characteristic analysis revealed that the vasopressin/norepinephrine ratio 1 x 10(-3) had a sensitivity of 97% (95% CI, 90%-99%) and a specificity of 85% (95% CI, 78%-91%) for detecting impending septic shock.	Norepinephrine	73-87	arginine vasopressin	Homo sapiens	61-72
16182977-9	2005	Low serum vasopressin/norepinephrine ratio can predict impending septic shock.	Norepinephrine	22-36	arginine vasopressin	Homo sapiens	10-21
16216936-13	2005	Increased inflammation was modulated by insulin-induced changes in CSF levels of norepinephrine and apolipoprotein E (both P<.05).	Norepinephrine	81-95	insulin	Homo sapiens	40-47
16148610-1	2005	BACKGROUND: Angiotensin II causes hypertension not only by direct constriction of vascular smooth muscle, but also by facilitating the release of noradrenaline from sympathetic terminals and by enhancing vascular noradrenaline sensitivity.	Norepinephrine	146-159	angiotensinogen	Rattus norvegicus	12-26
16148610-1	2005	BACKGROUND: Angiotensin II causes hypertension not only by direct constriction of vascular smooth muscle, but also by facilitating the release of noradrenaline from sympathetic terminals and by enhancing vascular noradrenaline sensitivity.	Norepinephrine	213-226	angiotensinogen	Rattus norvegicus	12-26
16116043-2	2005	We have previously shown that infusion of Ang II in the lateral cerebral ventricle raises blood pressure (BP), renal sympathetic nervous system activity (RSNA), and norepinephrine (NE) secretion from the posterior hypothalamic nuclei (PH), and reduces the abundance of interleukin-1beta (IL-1beta) and neuronal NO synthase (nNOS) mRNA in the PH.	Norepinephrine	165-179	angiotensinogen	Homo sapiens	42-48
16159376-0	2005	Locus coeruleus norepinephrine regulates the surge of prolactin during oestrus.	Norepinephrine	16-30	prolactin	Rattus norvegicus	54-63
19468644-3	2005	METHODS: Norepinephrine concentration-effect curves in the absence or presence of ropivacaine were plotted on isolated preparations of vas deferens of rats.	Norepinephrine	9-23	arginine vasopressin	Rattus norvegicus	135-138
16023617-1	2005	The ability of endothelins 1 and 3 (ET-1 and ET-3) to reduce neuronal norepinephrine release through ETB receptor activation involving nitric oxide (NO) pathways in the rat anterior hypothalamus region (AHR) was previously reported.	Norepinephrine	70-84	endothelin 1	Rattus norvegicus	15-34
15956086-6	2005	In controls, beta-endorphin reduced blood pressure (P < 0.01) and circulating norepinephrine (P < 0.02) and increased plasma atrial natriuretic factor (P < 0.003) and GH (P < 0.0001).	Norepinephrine	81-95	proopiomelanocortin	Homo sapiens	13-27
15956086-7	2005	In hypertensive patients, beta-endorphin decreased systemic vascular resistance (P < 0.0001), blood pressure (P < 0.0001), and plasma norepinephrine (P < 0.0001) and endothelin-1 (P < 0.0001) and raised circulating atrial natriuretic factor (P < 0.0001), GH (P < 0.0001), and IGF-I (P < 0.0001).	Norepinephrine	140-154	proopiomelanocortin	Homo sapiens	26-40
16210796-1	2005	Dopamine and noradrenaline are catecholamine neurotransmitters that are produced by biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine beta -hydroxylase (DBH).	Norepinephrine	13-26	dopamine beta-hydroxylase	Canis lupus familiaris	143-169
16210796-1	2005	Dopamine and noradrenaline are catecholamine neurotransmitters that are produced by biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine beta -hydroxylase (DBH).	Norepinephrine	13-26	dopamine beta-hydroxylase	Canis lupus familiaris	171-174
16005303-1	2005	OBJECTIVE: Endothelin-1 (ET-1) potentiates norepinephrine (NE)-induced contractile responses.	Norepinephrine	43-57	endothelin 1	Rattus norvegicus	11-23
15955417-0	2005	The role of norepinephrine and nitric oxide in activities of rat arginine vasopressin neurons in response to immune challenge.	Norepinephrine	12-26	arginine vasopressin	Rattus norvegicus	74-85
15953595-1	2005	Numerous studies have shown that angiotensin II causes vasoconstriction both by a direct action on smooth muscle cells (postjunctional effect) and indirectly through the facilitation of noradrenaline release from postganglionic sympathetic neurons (prejunctional effect).	Norepinephrine	186-199	angiotensinogen	Homo sapiens	33-47
15963537-2	2005	Microinjection of norepinephrine (NE) into the Cg3 area of the CC caused vasopressin release and pressor responses in unanesthetized rats.	Norepinephrine	18-32	arginine vasopressin	Rattus norvegicus	73-84
16005303-1	2005	OBJECTIVE: Endothelin-1 (ET-1) potentiates norepinephrine (NE)-induced contractile responses.	Norepinephrine	43-57	endothelin 1	Rattus norvegicus	25-29
16138261-10	2005	These results demonstrate that IN administration of ACTH(1-24) not only stimulates adrenocortical steroids, but also epinephrine and norepinephrine.	Norepinephrine	133-147	proopiomelanocortin	Homo sapiens	52-56
15890973-4	2005	Norepinephrine-mediated contractions were dependent on both GLUT4 and non-GLUT4 transporters, serotonin (5-HT)-mediated contractions were mainly GLUT4-dependent, and prostaglandin (PG) F(2alpha)-mediated contractions were dependent on non-GLUT4 transporters, whereas indinavir had no effect in GLUT4 knockout vessels.	Norepinephrine	0-14	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	60-65
15890973-4	2005	Norepinephrine-mediated contractions were dependent on both GLUT4 and non-GLUT4 transporters, serotonin (5-HT)-mediated contractions were mainly GLUT4-dependent, and prostaglandin (PG) F(2alpha)-mediated contractions were dependent on non-GLUT4 transporters, whereas indinavir had no effect in GLUT4 knockout vessels.	Norepinephrine	0-14	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	74-79
16138261-7	2005	Thirty minutes after IN or IV administration of ACTH(1-24), plasma norepinephrine levels increased by 55.9 +/- 13.4 % and 73.7 +/- 15.0 %, respectively, peaking 30 min after ACTH(1-24) administration, and decreasing to basal levels within 60 min.	Norepinephrine	67-81	proopiomelanocortin	Homo sapiens	48-52
16195034-5	2005	In the exercised group, the urinary noradrenaline/adrenaline ratio correlated positively with the training-induced changes in CD4+ T-lymphocytes and negatively with changes in the neutrophil/lymphocyte ratio.	Norepinephrine	36-49	CD4 molecule	Homo sapiens	126-129
15878998-9	2005	This suggests that norepinephrine activates endothelial alpha(2)-adrenoceptors.	Norepinephrine	19-33	adrenergic receptor, alpha 2a	Mus musculus	56-78
15878998-10	2005	In conclusion, the endothelium of mouse aorta has an alpha(2A)-adrenoceptor that responds to norepinephrine; promotes the release of nitric oxide, causing smooth muscle relaxation; and that can be directly visualized.	Norepinephrine	93-107	adrenergic receptor, alpha 2a	Mus musculus	53-75
15890973-4	2005	Norepinephrine-mediated contractions were dependent on both GLUT4 and non-GLUT4 transporters, serotonin (5-HT)-mediated contractions were mainly GLUT4-dependent, and prostaglandin (PG) F(2alpha)-mediated contractions were dependent on non-GLUT4 transporters, whereas indinavir had no effect in GLUT4 knockout vessels.	Norepinephrine	0-14	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	74-79
15890973-4	2005	Norepinephrine-mediated contractions were dependent on both GLUT4 and non-GLUT4 transporters, serotonin (5-HT)-mediated contractions were mainly GLUT4-dependent, and prostaglandin (PG) F(2alpha)-mediated contractions were dependent on non-GLUT4 transporters, whereas indinavir had no effect in GLUT4 knockout vessels.	Norepinephrine	0-14	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	74-79
15890973-4	2005	Norepinephrine-mediated contractions were dependent on both GLUT4 and non-GLUT4 transporters, serotonin (5-HT)-mediated contractions were mainly GLUT4-dependent, and prostaglandin (PG) F(2alpha)-mediated contractions were dependent on non-GLUT4 transporters, whereas indinavir had no effect in GLUT4 knockout vessels.	Norepinephrine	0-14	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	74-79
16049992-1	2005	OBJECTIVES: Tyrosine hydroxylase (TH) is a key enzyme in the biosynthesis of dopamine, epinephrine and norepinephrine.	Norepinephrine	103-117	tyrosine hydroxylase	Homo sapiens	12-32
16003188-0	2005	Angiotensin I-converting enzyme-dependent and neutral endopeptidase-dependent generation and degradation of angiotensin II contrarily modulate noradrenaline release: implications for vasopeptidase-inhibitor therapy?	Norepinephrine	143-156	angiotensin I converting enzyme	Rattus norvegicus	0-31
16003188-0	2005	Angiotensin I-converting enzyme-dependent and neutral endopeptidase-dependent generation and degradation of angiotensin II contrarily modulate noradrenaline release: implications for vasopeptidase-inhibitor therapy?	Norepinephrine	143-156	angiotensinogen	Rattus norvegicus	108-122
16003188-2	2005	Since angiotensin (ANG) II availability is decreased by ACE inhibition but is increased by NEP inhibition, we evaluated the influence of the vasopeptidase inhibitor omapatrilat on ANG II-dependent noradrenaline (NA) release.	Norepinephrine	197-210	angiotensinogen	Rattus norvegicus	180-186
16211406-1	2005	The non-neuronal monoamine transporters OCT1, OCT2 and EMT (human gene symbols SLC22A1-A3) efficiently transport a number of positively-charged monoamines and some small organic cations across the plasma membrane, and thus are implicated in the inactivation of released monoamine transmitters (e.g. noradrenaline, histamine, agmatine) in vivo.	Norepinephrine	299-312	solute carrier family 22 member 1	Homo sapiens	40-44
16211406-1	2005	The non-neuronal monoamine transporters OCT1, OCT2 and EMT (human gene symbols SLC22A1-A3) efficiently transport a number of positively-charged monoamines and some small organic cations across the plasma membrane, and thus are implicated in the inactivation of released monoamine transmitters (e.g. noradrenaline, histamine, agmatine) in vivo.	Norepinephrine	299-312	solute carrier family 22 member 1	Homo sapiens	79-86
16049992-1	2005	OBJECTIVES: Tyrosine hydroxylase (TH) is a key enzyme in the biosynthesis of dopamine, epinephrine and norepinephrine.	Norepinephrine	103-117	tyrosine hydroxylase	Homo sapiens	34-36
15951548-11	2005	CONCLUSIONS: These results suggest that norepinephrine released from the hepatic sympathetic nerve plays a critical role in protecting the liver from Fas mediated fulminant hepatitis, possibly via mechanisms including antiapoptotic proteins and interleukin 6.	Norepinephrine	40-54	interleukin 6	Mus musculus	245-258
16253158-0	2005	[Effects of angiotensin converting enzyme inhibitor with different doses on plasma brain natriuretic peptide and norepinephrine in patients with chronic heart failure].	Norepinephrine	113-127	angiotensin I converting enzyme	Homo sapiens	12-41
16253158-1	2005	OBJECTIVE: To investigate the effects of angiotensin converting enzyme inhibitor (ACEI) with different doses on the plasma brain natriuretic peptide and norepinephrine (NE) of patients with chronic heart failure and the feasibility and safety of high dose ACEI treatment.	Norepinephrine	153-167	angiotensin I converting enzyme	Homo sapiens	41-70
15797951-0	2005	The Leu7Pro polymorphism of preproNPY is associated with decreased insulin secretion, delayed ghrelin suppression, and increased cardiovascular responsiveness to norepinephrine during oral glucose tolerance test.	Norepinephrine	162-176	beta-1,3-glucuronyltransferase 1	Homo sapiens	4-8
15879433-1	2005	DOPA decarboxylase (DDC; also known as L-amino acid decarboxylase; AADC) is involved in the synthesis of dopamine, norepinephrine and serotonin.	Norepinephrine	115-129	dopa decarboxylase	Homo sapiens	0-18
15879433-1	2005	DOPA decarboxylase (DDC; also known as L-amino acid decarboxylase; AADC) is involved in the synthesis of dopamine, norepinephrine and serotonin.	Norepinephrine	115-129	dopa decarboxylase	Homo sapiens	20-23
15879433-1	2005	DOPA decarboxylase (DDC; also known as L-amino acid decarboxylase; AADC) is involved in the synthesis of dopamine, norepinephrine and serotonin.	Norepinephrine	115-129	dopa decarboxylase	Homo sapiens	67-71
15949713-0	2005	Gut-derived norepinephrine plays an important role in up-regulating IL-1beta and IL-10.	Norepinephrine	12-26	interleukin 1 beta	Rattus norvegicus	68-76
15950014-6	2005	In brain regions expressing both the DAT and the norepinephrine transporter (NET), the relative contributions of dopamine and norepinephrine to ADHD pathophysiology and therapeutic response are obfuscated by the capacity of the NET to clear dopamine as well as norepinephrine.	Norepinephrine	49-63	solute carrier family 6 member 2	Homo sapiens	77-80
15950014-6	2005	In brain regions expressing both the DAT and the norepinephrine transporter (NET), the relative contributions of dopamine and norepinephrine to ADHD pathophysiology and therapeutic response are obfuscated by the capacity of the NET to clear dopamine as well as norepinephrine.	Norepinephrine	49-63	solute carrier family 6 member 2	Homo sapiens	228-231
15950014-6	2005	In brain regions expressing both the DAT and the norepinephrine transporter (NET), the relative contributions of dopamine and norepinephrine to ADHD pathophysiology and therapeutic response are obfuscated by the capacity of the NET to clear dopamine as well as norepinephrine.	Norepinephrine	126-140	solute carrier family 6 member 2	Homo sapiens	77-80
15995358-5	2005	They had functional adrenergic receptors, like cardiomyocytes, and exposure to norepinephrine led to phosphorylation of ERK1/2.	Norepinephrine	79-93	mitogen-activated protein kinase 3	Homo sapiens	120-126
15797951-6	2005	RESULTS: The subjects with Leu7/Pro7 genotype had decreased plasma NPY, norepinephrine (NE), and insulin concentrations and insulin to glucose ratios.	Norepinephrine	72-86	beta-1,3-glucuronyltransferase 1	Homo sapiens	27-31
15911163-1	2005	The alpha2A and alpha2C adrenergic receptor (AR) subtypes mediate antinociception when activated by the endogenous ligand norepinephrine.	Norepinephrine	122-136	adrenergic receptor, alpha 2a	Mus musculus	4-11
15917452-12	2005	IL-1beta increased noradrenaline release in the PVN of virgin, but not pregnant, rats.	Norepinephrine	19-32	interleukin 1 beta	Rattus norvegicus	0-8
15916971-5	2005	RESULTS: Significant improvement by application of FGF-2/chitosan hydrogels was found in systolic pressure at the left ventricle, +dp/dt maximum, and -dp/dt maximum during noradrenalin challenge at a dose of 1 microg/kg/min.	Norepinephrine	172-184	fibroblast growth factor 2	Oryctolagus cuniculus	51-56
15949696-4	2005	The effect of norepinephrine on PPARgamma gene expression, at least in-vitro, is negative, PPARgamma-ablated brown adipose tissue can express UCP1, and PGC-1alpha coactivates other transcription factors (including PPARalpha); thus, the significance of PPARgamma for the physiological control of UCP1 gene expression is not settled.	Norepinephrine	14-28	peroxisome proliferator activated receptor gamma	Homo sapiens	32-41
15917452-13	2005	However, naloxone infused directly into the PVN increased noradrenaline release after IL-1beta in pregnant rats.	Norepinephrine	58-71	interleukin 1 beta	Rattus norvegicus	86-94
15833600-0	2005	Systemic Interleukin-1beta stimulates the simultaneous release of norepinephrine in the paraventricular nucleus and the median eminence.	Norepinephrine	66-80	interleukin 1 beta	Rattus norvegicus	9-26
15833600-4	2005	Although the catecholamines, norepinephrine (NE) and dopamine (DA) are believed to be crucial factors in the stimulation of CRH neurons, it is not clear if they affect the cell bodies or terminals of these neurons to cause HPA activation.	Norepinephrine	29-43	corticotropin releasing hormone	Rattus norvegicus	124-127
15897923-4	2005	Chronic treatment with angiotensin II (0.7 mg/kg daily for 10 d) significantly raised arterial blood pressure in male but not female Sprague-Dawley rats; it upregulated the NAD(P)H oxidase gp67 phox subunit in the aorta of male but not female rats; and it exaggerated the vasoconstrictor responses to norepinephrine and serotonin in the mesenteric vascular bed (MVB) of male but not female rats.	Norepinephrine	301-315	angiotensinogen	Rattus norvegicus	23-37
15741261-4	2005	Higher sustained interstitial glycerol and norepinephrine levels were found after 7 and 12 d of Ang II infusion.	Norepinephrine	43-57	angiotensinogen	Rattus norvegicus	96-102
15926928-3	2005	Whereas c-Fos expression was increased in Orx neurons after SD, it was increased in MCH neurons after SR. We reasoned that Orx and MCH neurons could be differently modulated by noradrenaline (NA) and accordingly bear different adrenergic receptors (ARs).	Norepinephrine	177-190	hypocretin neuropeptide precursor	Rattus norvegicus	123-126
15820203-2	2005	Neuropeptide Y (NPY) and ATP are cotransmitters of norepinephrine (NE) and regulate renovascular resistance.	Norepinephrine	51-65	neuropeptide Y	Rattus norvegicus	0-14
15820203-2	2005	Neuropeptide Y (NPY) and ATP are cotransmitters of norepinephrine (NE) and regulate renovascular resistance.	Norepinephrine	51-65	neuropeptide Y	Rattus norvegicus	16-19
15741261-8	2005	Nonselective-beta-adrenergic and Ang II-receptor1 blockade markedly attenuated the rise of norepinephrine, preventing catabolic effects.	Norepinephrine	91-105	angiotensinogen	Rattus norvegicus	33-39
15763139-1	2005	The norepinephrine transporter (NET) is a membrane protein responsible for transporting extracellular norepinephrine.	Norepinephrine	4-18	solute carrier family 6 member 2	Homo sapiens	32-35
15930502-5	2005	In mice lacking norepinephrine and epinephrine, many of these regions exhibited significantly reduced activation (e.g., hippocampal CA1), while other regions did not (e.g., hippocampal CA3).	Norepinephrine	16-30	carbonic anhydrase 3	Mus musculus	185-188
15866053-10	2005	While, however, noradrenaline attenuated the LPS-induced release of TNF-alpha and IL-6, dopamine was ineffective in modulating this response.	Norepinephrine	16-29	tumor necrosis factor	Rattus norvegicus	68-77
15866053-10	2005	While, however, noradrenaline attenuated the LPS-induced release of TNF-alpha and IL-6, dopamine was ineffective in modulating this response.	Norepinephrine	16-29	interleukin 6	Rattus norvegicus	82-86
15763139-3	2005	The regional distribution of the NET has been defined by synaptosomal uptake of norepinephrine and by autoradiographic approaches in rodent and primate brain.	Norepinephrine	80-94	solute carrier family 6 member 2	Homo sapiens	33-36
15763140-1	2005	Binding assays for the norepinephrine (NE) transporter (NET) with [3H]nisoxetine have generally yielded weak potencies for compounds related to cocaine and 1-(2-(di(4-fluorophenyl)-methoxy)-ethyl)-4-(3-phenylpropyl)piperazine (GBR 12909), as compared with their functional activity in inhibiting NE uptake.	Norepinephrine	23-37	solute carrier family 6 member 2	Homo sapiens	56-59
15781025-0	2005	Effect of noradrenaline and isoproterenol on lipopolysaccharide-induced tumor necrosis factor-alpha production in whole blood from patients with chronic heart failure and the role of beta-adrenergic receptors.	Norepinephrine	10-23	tumor necrosis factor	Homo sapiens	72-99
15781025-2	2005	This study demonstrated that noradrenaline and isoproterenol inhibit TNF-alpha production in patients with CHF in ex vivo whole blood in a dose-dependent fashion.	Norepinephrine	29-42	tumor necrosis factor	Homo sapiens	69-78
15831358-8	2005	RESULTS: During contraction in response to norepinephrine, Ang II induced concentration-dependent relaxation only in aortas isolated from SHR chronically treated with losartan (8 weeks; 30 mg/kg/day in drinking water).	Norepinephrine	43-57	angiotensinogen	Rattus norvegicus	59-65
15753325-8	2005	Vascular maladaptation with increased vasomotor tone, endothelial dysfunction, and increased sensitivity to angiotensin II and norepinephrine in manifest preeclampsia may be explained on the basis of angiotensin II-mediated mechanisms.	Norepinephrine	127-141	angiotensinogen	Homo sapiens	200-214
16181110-3	2005	In the presence of antigens or microbial products, such as agonists for Toll-like receptors 2 and 4, norepinephrine inhibits dendritic cell migration, antigen presentation and T-helper cells type 1 priming.	Norepinephrine	101-115	toll like receptor 2	Homo sapiens	72-99
15672410-0	2005	Effect of tumor necrosis factor-alpha on the reciprocal G-protein-induced regulation of norepinephrine release by the alpha2-adrenergic receptor.	Norepinephrine	88-102	tumor necrosis factor	Rattus norvegicus	10-37
15756641-4	2005	beta2AR activation by epinephrine, norepinephrine, and salbutamol suppressed the IgE receptor-dependent release of histamine, lipid mediators, and TNF-alpha, and inhibited SCF-dependent MC proliferation and migration.	Norepinephrine	35-49	tumor necrosis factor	Homo sapiens	147-156
15632189-1	2005	We previously identified DGK as one of nine mammalian DGK isoforms and reported on its regulation by interaction with RhoA and by translocation to the plasma membrane in response to noradrenaline.	Norepinephrine	182-195	diacylglycerol kinase beta	Homo sapiens	25-28
15774061-3	2005	As a supplementary vasopressor, arginine vasopressin can reverse hemodynamic failure and significantly decrease norepinephrine dosages.	Norepinephrine	112-126	arginine vasopressin	Homo sapiens	41-52
15715653-6	2005	However, 100 microm Fe(III)-dopamine in the presence of 100 microm dicoumarol, an inhibitor of DT-diaphorase, induced toxicity (44% cell death; p < 0.001), which was inhibited by 2 microm nomifensine, 30 microm reboxetine and 2 mm norepinephrine.	Norepinephrine	234-248	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	95-108
15824970-1	2005	PNMT (phenylethanolamine-N-methyl-transferase) is the enzyme that catalyzes the formation of epinephrine from norepinephrine.	Norepinephrine	110-124	phenylethanolamine-N-methyltransferase	Mus musculus	0-4
15824970-1	2005	PNMT (phenylethanolamine-N-methyl-transferase) is the enzyme that catalyzes the formation of epinephrine from norepinephrine.	Norepinephrine	110-124	phenylethanolamine-N-methyltransferase	Mus musculus	6-45
15710461-1	2005	Previous studies indicate that norepinephrine and epinephrine modulate production of interleukin-1(beta) (IL-1(beta)) by activated macrophages, but it is not known if macrophage-derived catecholamines affect IL-1(beta).	Norepinephrine	31-45	interleukin 1 beta	Mus musculus	85-104
15710461-1	2005	Previous studies indicate that norepinephrine and epinephrine modulate production of interleukin-1(beta) (IL-1(beta)) by activated macrophages, but it is not known if macrophage-derived catecholamines affect IL-1(beta).	Norepinephrine	31-45	interleukin 1 beta	Mus musculus	106-116
15752405-6	2005	The reference point for the control group was the time point at which doses of norepinephrine exceeded 0.3 microg kg(-1) min(-1).	Norepinephrine	79-93	CD59 molecule (CD59 blood group)	Homo sapiens	121-127
15715653-7	2005	The neuroprotective action of norepinephrine can be explained by (1) its ability to form complexes with Fe3+, (2) the uptake of Fe-norepinephrine complex via the norepinephrine transporter and (3) lack of toxicity of the Fe-norepinephrine complex even when DT-diaphorase is inhibited.	Norepinephrine	30-44	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	257-270
15721177-2	2005	In brain neurons, tumor necrosis factor-alpha (TNF) levels intensify and TNF-inhibition of norepinephrine (NE) release, dependent upon alpha(2)-adrenergic activation, amplifies during neuropathic pain onset.	Norepinephrine	91-105	tumor necrosis factor	Rattus norvegicus	73-76
15764840-0	2005	Receptor subtypes mediating the inotropic effects and Ca(2+) signaling induced by endothelin-1 through crosstalk with norepinephrine in canine ventricular myocardium.	Norepinephrine	118-132	endothelin 1	Canis lupus familiaris	82-94
15795476-19	2005	Moreover we believe, that the fasting-induced significant increase in plasma IL-6 concentration at rest, accompanied by higher plasma norepinephrine concentration and lower RQ, belongs to the physiological responses, maintaining energy homeostasis in the fasting state.	Norepinephrine	134-148	interleukin 6	Homo sapiens	77-81
16019595-2	2005	Several contributing factors have been proposed for this phenomenon in lactation, including the suckling stimulus from the pups, hormones (oxytocin and prolactin) and opioids, a decrease in the ability of noradrenaline to potentiate hypothalamic responses and changes in pituitary responsiveness to ACTH secretagogues (AVP and CRF).	Norepinephrine	205-218	proopiomelanocortin	Homo sapiens	299-303
15764840-2	2005	However, ET-1 induced a marked sustained positive inotropic effect (PIE) subsequent to a transient NIE in the presence of norepinephrine (NE) at low concentrations (0.1 - 1 nM) and elicited a pronounced sustained NIE in the presence of NE at high concentrations (around 100 nM).	Norepinephrine	122-136	endothelin 1	Canis lupus familiaris	9-13
15504733-6	2005	MAT2A mRNA and MAT II protein were increased in organ culture by treatment with norepinephrine (NE), the sympathetic neurotransmitter that stimulates the pineal gland at night.	Norepinephrine	80-94	methionine adenosyltransferase 2A	Homo sapiens	0-5
15630045-0	2005	Angiotensin-(1-7) and bradykinin in norepinephrine release in the central nervous system of hypertension.	Norepinephrine	36-50	kininogen 1	Homo sapiens	22-32
15770879-8	2005	Variables associated with higher concentrations of TNFalpha were; lower ejection fraction (P=0.04), worse functional class (P=0.007), coronary artery disease (P=0.05), chronic renal failure (P=0.02), arterial hypertension (P=0.05), higher concentrations of epinephrine (P=0.03) and norepinephrine (P=0.05).	Norepinephrine	282-296	tumor necrosis factor	Homo sapiens	51-59
15383007-1	2005	ANG II (angiotensin II) facilitates catecholamine release from the adrenal medulla and neuronal NE (noradrenaline) release.	Norepinephrine	100-113	angiotensinogen	Homo sapiens	8-22
15470085-3	2005	Tamsulosin competitively antagonized the contractions induced by noradrenaline in vitro in the epididymal portion of the vas deferens with a potency pA(2) value of 9.2 +/- 0.8.	Norepinephrine	65-78	arginine vasopressin	Rattus norvegicus	121-124
15504733-6	2005	MAT2A mRNA and MAT II protein were increased in organ culture by treatment with norepinephrine (NE), the sympathetic neurotransmitter that stimulates the pineal gland at night.	Norepinephrine	80-94	methionine adenosyltransferase 2A	Homo sapiens	15-21
16435190-9	2005	The ratios of brain noradrenaline to dopamine and of adrenaline to dopamine were also increased by the treatment, suggesting that the activity of dopamine beta-hydroxylase, a copper-dependent enzyme, was improved by the treatment.	Norepinephrine	20-33	dopamine beta hydroxylase	Mus musculus	146-171
15813642-5	2005	In addition, the SP/NK1R system shows significant spatial overlap with neurotransmitters such as serotonin and noradrenaline (norepinephrine), which are known to be involved in the regulation of stress, mood and anxiety.	Norepinephrine	111-124	tachykinin precursor 1	Homo sapiens	17-19
15813642-5	2005	In addition, the SP/NK1R system shows significant spatial overlap with neurotransmitters such as serotonin and noradrenaline (norepinephrine), which are known to be involved in the regulation of stress, mood and anxiety.	Norepinephrine	126-140	tachykinin precursor 1	Homo sapiens	17-19
15518901-9	2004	Pretreatment with 6-hydroxydopamine (6-OHDA) which destroys noradrenaline neuron of descending pain inhibitory systems in the spinal cord markedly abridged the latency and augmented the duration of PACAP-induced aversive responses.	Norepinephrine	60-73	adenylate cyclase activating polypeptide 1	Mus musculus	198-203
16336034-3	2005	In contrast, blocking 5-HT2A receptors in the presence of serotonin reuptake inhibition using the experimental compound YM992 enhances both serotonin and norepinephrine release.	Norepinephrine	154-168	5-hydroxytryptamine receptor 2A	Homo sapiens	22-28
15694697-4	2005	In contrast, in genetically predisposed subjects, prone to the development of essential hypertension, the insulin-induced vasodilatation is compensated by an increased heart rate and cardiac output (to avoid hypotension), mediated by an abnormal sympathetic overactivity, (characterised by high norepinephrine spillover rates and (frequently) a hyperdynamic circulation), while the PVR remains low during the early phase of developing EH.	Norepinephrine	295-309	insulin	Homo sapiens	106-113
15719846-7	2005	They show that vasopressin potentiates norepinephrine effects, increases blood pressure significantly in patients with vasodilatory shock and may improve renal function.	Norepinephrine	39-53	arginine vasopressin	Homo sapiens	15-26
15589045-0	2005	Norepinephrine in mice inhibits secretion of splenic IL-6 during the dark period but stimulates its secretion in the light period--possible role of the corticosterone tone.	Norepinephrine	0-14	interleukin 6	Mus musculus	53-57
15675318-6	2005	Also, norepinephrine increases sodium reabsorption in proximal tubules, and in part augments renin-aldosterone system that increases sodium reabsorption in distal nephron.	Norepinephrine	6-20	renin	Homo sapiens	93-98
15319202-1	2004	We reported previously that endothelium-intact superior mesenteric arteries (SMA) from N(omega)-nitro-L-arginine (L-NNA)-treated hypertensive rats (LHR) contract more to norepinephrine (NE) than SMA from control rats.	Norepinephrine	170-184	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	148-151
15597398-1	2004	Dopamine beta-monooxygenase (DBM, EC 1.14.17.1) catalyzes the oxidation of dopamine into (R)-noradrenaline.	Norepinephrine	89-106	dopamine beta-hydroxylase	Bos taurus	0-27
15567974-4	2004	RESULTS: In D1 ovaries, NPY, VIP or SP, both alone and with norepinephrine, generally decreased the release of Po.	Norepinephrine	60-74	neuropeptide Y	Rattus norvegicus	24-27
16871320-1	2004	The norepinephrine transporter (NET) is located in the plasma membrane of noradrenergic neurons, where it functions to take up synaptically released norepinephrine (NE).	Norepinephrine	4-18	solute carrier family 6 member 2	Homo sapiens	32-35
15597766-2	2004	For this purpose, the authors made an immunohistochemical determination of the sympathetic fibers by using an antibody against norepinephrine-synthetic enzyme, tyrosine hydroxylase (TH).	Norepinephrine	127-141	tyrosine hydroxylase	Homo sapiens	160-180
15567974-4	2004	RESULTS: In D1 ovaries, NPY, VIP or SP, both alone and with norepinephrine, generally decreased the release of Po.	Norepinephrine	60-74	vasoactive intestinal peptide	Rattus norvegicus	29-32
15567974-6	2004	In D2, NPY, VIP or SP, both alone and with norepinephrine, increased Po release.	Norepinephrine	43-57	neuropeptide Y	Rattus norvegicus	7-10
15567974-6	2004	In D2, NPY, VIP or SP, both alone and with norepinephrine, increased Po release.	Norepinephrine	43-57	vasoactive intestinal peptide	Rattus norvegicus	12-15
15567974-7	2004	The effect of NPY and SP was modified by norepinephrine.	Norepinephrine	41-55	neuropeptide Y	Rattus norvegicus	14-17
15502056-5	2004	Therefore, we examined the effects of various adrenergic drugs (dobutamine, xamoterol, clenbuterol, epinephrine, norepinephrine, and phenylephrine) on the activation of NF-kappaB, on the NF-kappaB-driven reporter gene activity, and on the expression of the NF-kappaB target gene interleukin (IL)-8.	Norepinephrine	113-127	nuclear factor kappa B subunit 1	Homo sapiens	169-178
15531715-1	2004	The prolactin pulse down-regulates mammary type I deiodinase responsiveness to norepinephrine.	Norepinephrine	79-93	prolactin	Homo sapiens	4-13
15485689-0	2004	Inhibition of iNOS augments cardiovascular action of noradrenaline in streptozotocin-induced diabetes.	Norepinephrine	53-66	nitric oxide synthase 2	Rattus norvegicus	14-18
15496310-2	2004	Responses to exogenous noradrenaline were inhibited with high affinity by prazosin (pKB, 9.3) and 5-methyl-urapidil (pKB, 9.2) and with low affinity by 8-[2-[4-(2-methoxyphenyl)-1 piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione (BMY 7378) (pA(2), 6.7).	Norepinephrine	23-36	thymoma viral proto-oncogene 1	Mus musculus	84-87
15496310-2	2004	Responses to exogenous noradrenaline were inhibited with high affinity by prazosin (pKB, 9.3) and 5-methyl-urapidil (pKB, 9.2) and with low affinity by 8-[2-[4-(2-methoxyphenyl)-1 piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione (BMY 7378) (pA(2), 6.7).	Norepinephrine	23-36	thymoma viral proto-oncogene 1	Mus musculus	117-120
15369781-3	2004	In contrast, transcripts of phenylethanolamine-N-methyltransferase, the enzyme catalyzing the conversion of norepinephrine into epinephrine, were not detected in aortae in either mouse strain.	Norepinephrine	108-122	phenylethanolamine-N-methyltransferase	Mus musculus	28-66
15364620-1	2004	OBJECTIVE: Catechol O-methyltransferase (COMT) is believed to exert degradative action at high norepinephrine (NE) levels.	Norepinephrine	95-109	catechol O-methyltransferase	Oryctolagus cuniculus	11-39
15364025-0	2004	Amitriptyline administration transforms tumor necrosis factor-alpha regulation of norepinephrine release in the brain.	Norepinephrine	82-96	tumor necrosis factor	Rattus norvegicus	40-67
15364025-1	2004	The present study demonstrates that the mixed action antidepressant drug amitriptyline enhances norepinephrine (NE) release by transforming the nature of the response of neurons to both tumor necrosis factor-alpha (TNF) as well as to an alpha(2)-adrenergic agonist in an area of the central nervous system (CNS) rich in adrenergic neurons.	Norepinephrine	96-110	tumor necrosis factor	Rattus norvegicus	186-213
15364025-4	2004	Exposure to TNF, as well as activation of the alpha(2)-adrenergic autoreceptor inhibits stimulation-evoked norepinephrine (NE) release from adrenergic neurons of the CNS from naive rats.	Norepinephrine	107-121	tumor necrosis factor	Rattus norvegicus	12-15
15205164-4	2004	From the fact that norepinephrine acts on prejunctional alpha(2)-adrenoceptors to inhibit the evoked release of sympathetic cotransmitters, we carried out experiments in the presence of the alpha(2)-adrenergic receptor antagonist yohimbine to investigate the possibility that the decrease in NPY observed in the presence of l-NAME was due to the increase in bioactive norepinephrine acting on its autoreceptor.	Norepinephrine	19-33	neuropeptide Y	Rattus norvegicus	292-295
15364620-1	2004	OBJECTIVE: Catechol O-methyltransferase (COMT) is believed to exert degradative action at high norepinephrine (NE) levels.	Norepinephrine	95-109	catechol O-methyltransferase	Oryctolagus cuniculus	41-45
15190089-4	2004	To more specifically address the role of adrenergic signaling in sleep/wake regulation, we performed electroencephalographic and electromyographic recordings in mice with a targeted disruption of the gene for dopamine beta-hydroxylase, the enzyme that converts dopamine to norepinephrine.	Norepinephrine	273-287	dopamine beta hydroxylase	Mus musculus	209-234
15361762-0	2004	Endothelin-B-receptor-selective antagonist inhibits endothelin-1 induced potentiation on the vasoconstriction to noradrenaline and angiotensin II.	Norepinephrine	113-126	endothelin receptor type B	Homo sapiens	0-21
15361762-0	2004	Endothelin-B-receptor-selective antagonist inhibits endothelin-1 induced potentiation on the vasoconstriction to noradrenaline and angiotensin II.	Norepinephrine	113-126	endothelin 1	Homo sapiens	52-64
15361762-2	2004	Whether functional constrictive endothelin-B-receptors play a role in the endothelin-1-mediated potentiation of vasoconstriction to angiotensin II and noradrenaline is thus far unknown.	Norepinephrine	151-164	endothelin 1	Homo sapiens	74-86
15361762-6	2004	RESULTS: Endothelin-1 potentiated the effects of angiotensin II and noradrenaline (-944 +/- 139 perfusion units (PU), P < 0.01; -926 +/- 117 PU, P < 0.05, respectively).	Norepinephrine	68-81	endothelin 1	Homo sapiens	9-21
15379886-1	2004	The present study investigated the role of alpha2A-adrenoceptor (alpha2A-AR) subtype in the regulation of noradrenaline (NA) and dopamine (DA) release in the nucleus accumbens (NAc).	Norepinephrine	106-119	adrenergic receptor, alpha 2a	Mus musculus	43-63
15379886-1	2004	The present study investigated the role of alpha2A-adrenoceptor (alpha2A-AR) subtype in the regulation of noradrenaline (NA) and dopamine (DA) release in the nucleus accumbens (NAc).	Norepinephrine	106-119	adrenergic receptor, alpha 2a	Mus musculus	65-75
15326086-2	2004	To better understand the role of different isoforms of TGF-beta in the cardiac remodeling process induced by norepinephrine (NE), the expression of TGF-beta1, TGF-beta2, and TGF-beta3 was studied and compared with the expression of collagen.	Norepinephrine	109-123	transforming growth factor, beta 1	Rattus norvegicus	55-63
15326090-0	2004	Gender dependency in the pathogenesis of cardiac hypertrophy: effect of norepinephrine on transforming growth factor-beta release in female heart.	Norepinephrine	72-86	transforming growth factor beta 1	Homo sapiens	90-121
15361762-9	2004	CONCLUSIONS: These data suggest that functional vasoconstrictive endothelin-B receptors on vascular smooth muscle cells may contribute to the potentiating effects of high local concentrations of endothelin-1 on the vasoconstriction to noradrenaline and angiotensin II in human microcirculation.	Norepinephrine	235-248	endothelin 1	Homo sapiens	195-207
15361762-9	2004	CONCLUSIONS: These data suggest that functional vasoconstrictive endothelin-B receptors on vascular smooth muscle cells may contribute to the potentiating effects of high local concentrations of endothelin-1 on the vasoconstriction to noradrenaline and angiotensin II in human microcirculation.	Norepinephrine	235-248	angiotensinogen	Homo sapiens	253-267
15385601-0	2004	Chronic morphine sensitizes the brain norepinephrine system to corticotropin-releasing factor and stress.	Norepinephrine	38-52	corticotropin releasing hormone	Rattus norvegicus	63-93
15385601-4	2004	Chronic morphine selectively sensitized locus ceruleus (LC)-norepinephrine (NE) neurons to corticotropin-releasing factor (CRF), an integral mediator of the stress response.	Norepinephrine	60-74	corticotropin releasing hormone	Rattus norvegicus	91-121
15621715-4	2004	Furthermore, catecholamines such as 3,4-dihydroxyphenylalanine (DOPA), dopamine or norepinephrine were more effective than caffeic acid or pyrocatechol in promoting Cu(2+)-mediated inactivation of PON1, suggesting the importance of dihydroxybenzene group as well as amino group.	Norepinephrine	83-97	paraoxonase 1	Homo sapiens	197-201
15337646-2	2004	The purpose of the present study was to determine whether norepinephrine transporter gene (NET) and serotonin transporter gene (5-HTT) polymorphisms are associated with the antidepressant response to milnacipran, a dual serotonin/norepinephrine reuptake inhibitor.	Norepinephrine	58-72	solute carrier family 6 member 2	Homo sapiens	91-94
15363956-0	2004	Brain phospholipase C-diacylglycerol lipase pathway is involved in vasopressin-induced release of noradrenaline and adrenaline from adrenal medulla in rats.	Norepinephrine	98-111	arginine vasopressin	Rattus norvegicus	67-78
15363956-2	2004	administered arginine-vasopressin evokes the release of noradrenaline and adrenaline from adrenal medulla by brain thromboxane A2-mediated mechanisms in rats.	Norepinephrine	56-69	arginine vasopressin	Rattus norvegicus	22-33
15363956-13	2004	These results suggest that vasopressin evokes the release of noradrenaline and adrenaline from adrenal medulla by the brain PLC- and diacylglycerol lipase-dependent mechanisms in rats.	Norepinephrine	61-74	arginine vasopressin	Rattus norvegicus	27-38
15349104-7	2004	RESULTS: Recombinant TAT-HSP20 inhibited norepinephrine-induced contraction of rabbit aortic and HSV segments.	Norepinephrine	41-55	heat shock protein family B (small) member 6	Homo sapiens	25-30
15318031-2	2004	DOPA decarboxylase (DDC) is an enzyme involved directly in the synthesis of dopamine and serotonin, and indirectly in the synthesis of noradrenaline.	Norepinephrine	135-148	dopa decarboxylase	Homo sapiens	0-18
15318031-2	2004	DOPA decarboxylase (DDC) is an enzyme involved directly in the synthesis of dopamine and serotonin, and indirectly in the synthesis of noradrenaline.	Norepinephrine	135-148	dopa decarboxylase	Homo sapiens	20-23
15193150-0	2004	Noradrenaline represses PPAR (peroxisome-proliferator-activated receptor) gamma2 gene expression in brown adipocytes: intracellular signalling and effects on PPARgamma2 and PPARgamma1 protein levels.	Norepinephrine	0-13	peroxisome proliferator activated receptor gamma	Homo sapiens	30-80
15193150-3	2004	The aim of the present study was thus to investigate the influence of noradrenaline on PPARgamma gene expression in brown adipocytes.	Norepinephrine	70-83	peroxisome proliferator activated receptor gamma	Homo sapiens	87-96
15082752-2	2004	To establish this role, field stimulation and superfusion of rat hippocampal slices was employed to investigate the regulation of norepinephrine (NE) release by TNF.	Norepinephrine	130-144	tumor necrosis factor	Rattus norvegicus	161-164
15349104-8	2004	Similarly, TAT-HSP20 induced smooth muscle relaxation in HSV segments precontracted with norepinephrine.	Norepinephrine	89-103	heat shock protein family B (small) member 6	Homo sapiens	15-20
15177927-0	2004	NPY and NPY Y1 receptor effects on noradrenaline overflow from the rat brain in vitro.	Norepinephrine	35-48	neuropeptide Y	Rattus norvegicus	8-11
15100092-7	2004	Addition of the sympathetic agonists norepinephrine, isoprenaline, or BRL-37344 (beta(3)-agonist) led to falls in NGF gene expression and secretion by 3T3-L1 adipocytes, as did IL-6 and the PPARgamma agonist rosiglitazone.	Norepinephrine	37-51	interleukin 6	Mus musculus	177-181
15329388-0	2004	Orexin-A infusion in the locus ceruleus triggers norepinephrine (NE) release and NE-induced long-term potentiation in the dentate gyrus.	Norepinephrine	49-63	hypocretin neuropeptide precursor	Rattus norvegicus	0-8
15177927-2	2004	The aim of this study was to investigate whether a functional interaction occurs among neuropeptide Y (NPY) at NPY Y1 receptors and noradrenaline overflow, as this may contribute to the regulation of appetite.	Norepinephrine	132-145	neuropeptide Y	Rattus norvegicus	87-101
15177927-2	2004	The aim of this study was to investigate whether a functional interaction occurs among neuropeptide Y (NPY) at NPY Y1 receptors and noradrenaline overflow, as this may contribute to the regulation of appetite.	Norepinephrine	132-145	neuropeptide Y	Rattus norvegicus	103-106
15177927-5	2004	Perfusion with NPY and [Leu31,Pro34]NPY significantly reduced noradrenaline overflow from the hypothalamus and medulla.	Norepinephrine	62-75	neuropeptide Y	Rattus norvegicus	15-18
15177927-5	2004	Perfusion with NPY and [Leu31,Pro34]NPY significantly reduced noradrenaline overflow from the hypothalamus and medulla.	Norepinephrine	62-75	neuropeptide Y	Rattus norvegicus	36-39
15177927-7	2004	Results from this study provide evidence of NPY Y1 receptor-mediated inhibition of noradrenaline release in the hypothalamus and medulla, further illustrating a complex interaction between neurotransmitters and neuropeptides within the rat brain.	Norepinephrine	83-96	neuropeptide Y	Rattus norvegicus	44-47
15292328-4	2004	Norepinephrine, epinephrine, isoproterenol, and OR486 (COMT inhibitor) abrogated the inhibitory effects of estradiol on SMC growth and ERK1/2 phosphorylation.	Norepinephrine	0-14	mitogen-activated protein kinase 3	Homo sapiens	135-141
15305046-5	2004	The intracerebroventricular injection of CRH significantly augmented the content of norepinephrine (NE) in locus coeruleus (LC) of rats, which was significantly suppressed by the intracerebroventricular injection of TMCA.	Norepinephrine	84-98	corticotropin releasing hormone	Rattus norvegicus	41-44
15034673-5	2004	Using the specific agonist docosatetraenoylethanolamide (DEA), we have observed that the norepinephrine-induced migration of colon carcinoma cells is inhibited by the CB1-R.	Norepinephrine	89-103	cannabinoid receptor 1	Homo sapiens	167-172
15213629-3	2004	In the present study the influence of norepinephrine on the developmental hierarchy of bone marrow cells after thermal injury and sepsis was determined by assessing the clonogenic potential and LPS-stimulated cytokine responses of mature macrophages derived from CD117 and ER-MP12 bone marrow progenitor cells.	Norepinephrine	38-52	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	263-268
15213629-10	2004	TNF-alpha and IL-6 cytokine responses to LPS were markedly influenced by the specific progenitor cells involved as well as the injury conditions and the status of norepinephrine prior to injury.	Norepinephrine	163-177	tumor necrosis factor	Homo sapiens	0-9
15213629-10	2004	TNF-alpha and IL-6 cytokine responses to LPS were markedly influenced by the specific progenitor cells involved as well as the injury conditions and the status of norepinephrine prior to injury.	Norepinephrine	163-177	interleukin 6	Homo sapiens	14-18
15213629-11	2004	In burn sepsis the depletion of norepinephrine resulted in a dramatic decrease in both IL-6 and TNF-alpha production by both progenitor-derived macrophages.	Norepinephrine	32-46	interleukin 6	Homo sapiens	87-91
15213629-11	2004	In burn sepsis the depletion of norepinephrine resulted in a dramatic decrease in both IL-6 and TNF-alpha production by both progenitor-derived macrophages.	Norepinephrine	32-46	tumor necrosis factor	Homo sapiens	96-105
15226636-0	2004	Altered effects of angiotensin ii type 1 and type 2 receptor blockers on cardiac norepinephrine release and inotropic responses during cardiac sympathetic nerve stimulation in aorto-caval shunt rats.	Norepinephrine	81-95	angiotensin II receptor, type 1b	Rattus norvegicus	19-60
15120484-0	2004	Regulation of hypoxia-induced release of corticotropin-releasing factor in the rat hypothalamus by norepinephrine.	Norepinephrine	99-113	corticotropin releasing hormone	Rattus norvegicus	41-71
15245872-1	2004	We have previously reported that endothelin 1 and 3 (ET-1, ET-3) through the ETB receptor decrease norepinephrine release in the anterior hypothalamus and activate the nitric oxide (NO) pathway.	Norepinephrine	99-113	endothelin 1	Rattus norvegicus	33-51
15027894-7	2004	Fibrinogen was higher in men with high adrenaline (F(7,631)=5.68, P=0.018; where the subscripted value represents the degrees of freedom) and high noradrenaline (F(7,631)=4.19, P=0.041) compared with men with low excretion of the respective hormones.	Norepinephrine	147-160	fibrinogen beta chain	Homo sapiens	0-10
14751847-2	2004	Subcutaneous administration of adrenomedullin (1.5 microg.kg(-1).h(-1)) for 1 wk inhibited the ANG II-induced (33.3 microg.kg(-1).h(-1) sc) increase in mean arterial pressure by 67% (P < 0.001) but had no effect of norepinephrine-induced (300 microg.kg(-1).h(-1) sc) hypertension.	Norepinephrine	218-232	angiotensinogen	Rattus norvegicus	95-101
15285793-0	2004	Inhibition of microglial inflammatory responses by norepinephrine: effects on nitric oxide and interleukin-1beta production.	Norepinephrine	51-65	interleukin 1 beta	Rattus norvegicus	95-112
14751845-4	2004	In norepinephrine-constricted vessels, incubation with N(G)-nitro-L-arginine methyl ester (L-NAME) resulted in a significant reduction in relaxation to BK.	Norepinephrine	3-17	kininogen 1	Homo sapiens	152-154
14751847-3	2004	Adrenomedullin enhanced the ANG II-induced improvement in systolic function, resulting in a further 9% increase (P < 0.01) in the left ventricular ejection fraction and 19% increase (P < 0.05) in the left ventricular fractional shortening measured by echocardiography, meanwhile norepinephrine-induced changes in systolic function were remained unaffected.	Norepinephrine	285-299	angiotensinogen	Rattus norvegicus	28-34
15145612-1	2004	Endogenous catecholamine, epinephrine and norepinephrine, and isoproterenol concentration-dependently induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, and inhibited that of IL-10 in human peripheral blood mononuclear cells (PBMC).	Norepinephrine	42-56	tumor necrosis factor	Homo sapiens	149-182
15212408-5	2004	Both norepinephrine and dopamine were able to suppress the production of tumor necrosis factor (TNF) in a dose-dependent fashion.	Norepinephrine	5-19	tumor necrosis factor	Homo sapiens	96-99
15212408-6	2004	Over the range of doses, norepinephrine is a more potent inhibitor of TNF production than dopamine.	Norepinephrine	25-39	tumor necrosis factor	Homo sapiens	70-73
15212408-9	2004	Norepinephrine is a more potent inhibitor of TNF than dopamine.	Norepinephrine	0-14	tumor necrosis factor	Homo sapiens	45-48
15167453-6	2004	Both NPP and bradykinin increased systolic (SBP) and diastolic (DBP) blood pressures, heart rate and plasma adrenaline and noradrenaline concentrations.	Norepinephrine	123-136	kininogen 1	Homo sapiens	13-23
15212408-0	2004	Norepinephrine is a more potent inhibitor of tumor necrosis factor over a range of doses than dopamine.	Norepinephrine	0-14	tumor necrosis factor	Homo sapiens	45-66
15212408-5	2004	Both norepinephrine and dopamine were able to suppress the production of tumor necrosis factor (TNF) in a dose-dependent fashion.	Norepinephrine	5-19	tumor necrosis factor	Homo sapiens	73-94
15158148-0	2004	Norepinephrine induces apoptosis in neonatal rat cardiomyocytes through a reactive oxygen species-TNF alpha-caspase signaling pathway.	Norepinephrine	0-14	tumor necrosis factor	Rattus norvegicus	98-101
15145612-1	2004	Endogenous catecholamine, epinephrine and norepinephrine, and isoproterenol concentration-dependently induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, and inhibited that of IL-10 in human peripheral blood mononuclear cells (PBMC).	Norepinephrine	42-56	interferon gamma	Homo sapiens	187-209
14726430-1	2004	Norepinephrine transporter (NET) function has a central role in the regulation of synaptic norepinephrine concentrations.	Norepinephrine	91-105	solute carrier family 6 member 2	Homo sapiens	0-26
14726430-1	2004	Norepinephrine transporter (NET) function has a central role in the regulation of synaptic norepinephrine concentrations.	Norepinephrine	91-105	solute carrier family 6 member 2	Homo sapiens	28-31
14726430-10	2004	In contrast, NET inhibition resulted in a similar suppression in the cold pressor and handgrip response, low-frequency blood pressure oscillations, and venous norepinephrine in the supine position.	Norepinephrine	159-173	solute carrier family 6 member 2	Homo sapiens	13-16
14726430-13	2004	Our observations suggest that the NET contribution to cardiac norepinephrine turnover may be decreased in women.	Norepinephrine	62-76	solute carrier family 6 member 2	Homo sapiens	34-37
15164608-1	2004	Following exocytotic release of the biogenic amine neurotransmitters, norepinephrine and dopamine, are removed from the synaptic cleft by the respective transporter, norepinephrine transporter (NET) and dopamine transporter (DAT) located on the plasma membrane.	Norepinephrine	70-84	solute carrier family 6 member 2	Homo sapiens	166-192
15020229-5	2004	Glutamate was a potent activator of PLD in neurons but not in astrocytes, whereas noradrenaline and carbachol increased PLD activity only in astrocytes.	Norepinephrine	82-95	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	120-123
15030373-16	2004	After haemorrhage, endothelin-1 seems to facilitate adrenaline release and to blunt noradrenaline release.	Norepinephrine	84-97	endothelin 1	Canis lupus familiaris	19-31
15036951-7	2004	Norepinephrine-induced Ca(2+) release and force generation were also markedly enhanced in PASMCs from FKBP12.6 null mice.	Norepinephrine	0-14	FK506 binding protein 1b	Mus musculus	102-110
14759556-0	2004	Angiotensin-(1-7) inhibits the angiotensin II-enhanced norepinephrine release in coarcted hypertensive rats.	Norepinephrine	55-69	angiotensinogen	Rattus norvegicus	31-45
14759557-0	2004	Modulatory effect of endothelin-1 and -3 on neuronal norepinephrine release in the rat posterior hypothalamus.	Norepinephrine	53-67	endothelin 1	Rattus norvegicus	21-40
15036951-0	2004	Role of FKBP12.6 in hypoxia- and norepinephrine-induced Ca2+ release and contraction in pulmonary artery myocytes.	Norepinephrine	33-47	FK506 binding protein 1b	Mus musculus	8-16
15090041-4	2004	The hindbrain NPY innervation of the hypothalamus is derived from cell bodies that coexpress norepinephrine or epinephrine.	Norepinephrine	93-107	neuropeptide Y	Rattus norvegicus	14-17
15126926-2	2004	Both noradrenaline and angiotensin II stimulate preproendothelin-1 gene expression, yet the effects of high doses of dihydropyridines on preproendothelin-1 expression in vivo remain unknown.	Norepinephrine	5-18	endothelin 1	Rattus norvegicus	48-66
14644765-3	2004	We observed that VEGF(165) (5 x 10(-16)-5 x 10(-11) M) elicited a concentration-dependent decrease in perfusion pressure (i.e., vasorelaxation) in skin flaps preconstricted with a submaximal concentration of norepinephrine (NE), endothelin-1, or U-46619.	Norepinephrine	208-222	vascular endothelial growth factor A	Homo sapiens	17-21
14757704-6	2004	However, in vessels precontracted with norepinephrine, Ang II induces vasodilation followed by vasoconstriction.	Norepinephrine	39-53	angiotensinogen	Rattus norvegicus	55-61
14732211-0	2004	Norepinephrine induces apoptosis in neonatal rat endothelial cells via down-regulation of Bcl-2 and activation of beta-adrenergic and caspase-2 pathways.	Norepinephrine	0-14	BCL2, apoptosis regulator	Rattus norvegicus	90-95
14744612-0	2004	Increased vasoconstriction to noradrenaline by 1400W, inhibitor of iNOS, in rats with streptozotocin-induced diabetes.	Norepinephrine	30-43	nitric oxide synthase 2	Rattus norvegicus	67-71
14744612-2	2004	We examined if selective inhibition of iNOS by 1400W (N-3-aminomethyl-benzyl-acetamidine) increases vascular response to noradrenaline in rats with streptozotocin (60 mg/kg i.v.	Norepinephrine	121-134	nitric oxide synthase 2	Rattus norvegicus	39-43
14744612-7	2004	Thus, selective inhibition of iNOS by 1400W increases arterial and venous constriction to noradrenaline in conscious rats with streptozotocin-induced diabetes.	Norepinephrine	90-103	nitric oxide synthase 2	Rattus norvegicus	30-34
14716224-9	2004	Ang I and II enhanced the stimulation-induced noradrenaline release significantly more potent in tissues of patients pretreated with ACE inhibitors than without.	Norepinephrine	46-59	angiotensin I converting enzyme	Homo sapiens	133-136
14701907-0	2004	Enhanced hippocampal noradrenaline and serotonin release in galanin-overexpressing mice after repeated forced swimming test.	Norepinephrine	21-34	galanin and GMAP prepropeptide	Mus musculus	60-67
14665508-9	2003	CONCLUSIONS: In norepinephrine-dependent patients in septic shock, continuous infusion of low-dose vasopressin results in a significant increase of the P(g-a)CO(2) gap compatible with GI hypoperfusion.	Norepinephrine	16-30	arginine vasopressin	Homo sapiens	99-110
15183527-3	2004	alpha2A- and alpha2C-ARs function as both autoreceptors (presynaptic) on noradrenergic neurons, where they regulate norepinephrine (NE) release, and as postsynaptic receptors on neurons that receive noradrenergic innervation, where they regulate the release of other neurotransmitters (heteroreceptor).	Norepinephrine	116-130	adrenergic receptor, alpha 2a	Mus musculus	0-7
14675848-9	2003	Aging itself is associated with elevated myocardial and serum norepinephrine levels, which is associated with down-regulation of beta-1 receptors.	Norepinephrine	62-76	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	129-135
14871027-0	2003	Noradrenaline-induced contraction mediated by endothelial COX-1 metabolites in the rat coronary artery.	Norepinephrine	0-13	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	58-63
14644033-1	2003	Using a spleen slice microsuperfusion technique in mice, we have previously characterized the role of norepinephrine (NE) and other neurotransmitters for sympathetic modulation of IL-6 and TNF secretion of splenic macrophages.	Norepinephrine	102-116	interleukin 6	Mus musculus	180-184
14642608-0	2003	NCX-1000, a nitric oxide-releasing derivative of ursodeoxycholic acid, ameliorates portal hypertension and lowers norepinephrine-induced intrahepatic resistance in the isolated and perfused rat liver.	Norepinephrine	114-128	solute carrier family 8 member A1	Rattus norvegicus	0-3
14642608-1	2003	BACKGROUND/AIMS: We studied whether acute administration of NCX-1000, a nitric oxide (NO)-releasing derivative of ursodeoxycholic acid (UDCA), to animals with established liver cirrhosis decreases intrahepatic resistance and modulates hepatic vascular hypereactivity to norepinephrine (NE).	Norepinephrine	270-284	solute carrier family 8 member A1	Rattus norvegicus	60-63
14644033-1	2003	Using a spleen slice microsuperfusion technique in mice, we have previously characterized the role of norepinephrine (NE) and other neurotransmitters for sympathetic modulation of IL-6 and TNF secretion of splenic macrophages.	Norepinephrine	102-116	tumor necrosis factor	Mus musculus	189-192
12900412-9	2003	The cDNAs tomTHT1-3, tomTHT7-1, and tomTHT7-8 encoded proteins with a high degree of amino acid sequence homology, although the recombinant proteins had different preferences for octopamine and noradrenaline.	Norepinephrine	194-207	N-hydroxycinnamoyl-CoA:tyramine N-hydroxycinnamoyl transferase THT1-3	Solanum lycopersicum	10-19
14566941-1	2003	Recent evidence suggests that certain stressors release both endogenous opioids and corticotropin-releasing factor (CRF) to modulate activity of the locus coeruleus (LC)-norepinephrine (NE) system.	Norepinephrine	170-184	corticotropin releasing hormone	Rattus norvegicus	84-114
14597102-1	2003	We showed that norepinephrine (NE) hampers IL-12 and stimulates IL-10 production via adrenoceptors (ARs) in bone marrow-derived dendritic cells (BMDC) influencing their Th priming ability.	Norepinephrine	15-29	interleukin 10	Mus musculus	64-69
14647975-9	2003	Protein kinase C is involved in the enhancement by angiotensin II and bradykinin of electrically-evoked release of noradrenaline from the nerve terminals.	Norepinephrine	115-128	angiotensinogen	Rattus norvegicus	51-65
14625484-5	2003	Animals, receiving epinephrine therapy, showed a significantly prolonged upregulation of IL-6 mRNA expression at 4 h after LPS application in liver (P = 0.0014), spleen (P < 0.0001), and mesenteric lymph nodes (P = 0.0078) as compared with animals treated with norepinephrine or fluid resuscitation.	Norepinephrine	264-278	interleukin 6	Homo sapiens	89-93
14598308-1	2003	We previously reported that glucagon-like peptide-1 decreased corticotropin-releasing factor (CRF)-induced behaviors in neonatal chicks, and such an effect is hypothesized to act through norepinephrine (NE).	Norepinephrine	187-201	glucagon	Homo sapiens	28-51
14646609-9	2003	Indeed, the action of alpha-2 adrenoreceptor antagonists may involve the blockade of the action of noradrenaline synthesized from LD.	Norepinephrine	99-112	glycoprotein hormone subunit alpha 2	Homo sapiens	22-29
12900412-9	2003	The cDNAs tomTHT1-3, tomTHT7-1, and tomTHT7-8 encoded proteins with a high degree of amino acid sequence homology, although the recombinant proteins had different preferences for octopamine and noradrenaline.	Norepinephrine	194-207	N-hydroxycinnamoyl-CoA:tyramine N-hydroxycinnamoyl transferase THT7-8	Solanum lycopersicum	36-45
14612149-1	2003	The biogenic amine transporters belong to the class of Na+/Cl--coupled solute carriers and include the transporters for dopamine (DAT), norepinephrine (NET), and serotonin (SERT).	Norepinephrine	136-150	solute carrier family 6 member 4	Homo sapiens	173-177
14573772-4	2003	The aim of this study was to establish whether the allosteric potentiation of nAChR currents is transduced in downstream cellular responses to nAChR activation, namely increases in intracellular Ca2+ and [3H]noradrenaline release.	Norepinephrine	208-221	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	78-83
14573772-4	2003	The aim of this study was to establish whether the allosteric potentiation of nAChR currents is transduced in downstream cellular responses to nAChR activation, namely increases in intracellular Ca2+ and [3H]noradrenaline release.	Norepinephrine	208-221	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	143-148
14573772-9	2003	nAChR-mediated [3H]noradrenaline release from hippocampal slices was also potentiated by galantamine, with an additional component attributable to acetylcholinesterase inhibition and subsequent increase in acetylcholine.	Norepinephrine	19-32	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	0-5
12902204-2	2003	Some contractile agents, potassium chloride (KCl), adenosine 5"-triphosphate (ATP), noradrenaline (NA), and electrical field stimulation (EFS) caused contractions both in epididymal and prostatic portions of vas deferens.	Norepinephrine	84-97	arginine vasopressin	Rattus norvegicus	208-211
12837768-4	2003	Of 18 mutations where hNET amino acid residues were exchanged with those of the human dopamine transporter, MrIA had increased potency for inhibition of [3H]norepinephrine uptake for three mutations (in predicted extracellular loops 3 and 4 and transmembrane domain (TMD) 8) and decreased potency for one mutation (in TMD6 and intracellular loop (IL) 3).	Norepinephrine	157-171	solute carrier family 6 member 2	Homo sapiens	22-26
12837768-7	2003	A comparison of the results with previous data for desipramine and cocaine inhibition of norepinephrine uptake by the mutant hNETs reveals that MrIA binding to hNET occurs at a site that is distinct from but overlaps with the binding sites for tricyclic antidepressants and cocaine.	Norepinephrine	89-103	solute carrier family 6 member 2	Homo sapiens	125-129
12897061-1	2003	Ascorbic acid (vitamin C) is a cofactor required in catecholamine synthesis for conversion of dopamine to norepinephrine by dopamine beta-hydroxylase.	Norepinephrine	106-120	dopamine beta hydroxylase	Mus musculus	124-149
12965240-4	2003	We speculated that the increased freezing response of the alpha2A AR KO and D79N mice in the discrete cue setting was due to increased release of norepinephrine evoked by the unconditioned footshock stimulus.	Norepinephrine	146-160	adrenergic receptor, alpha 2a	Mus musculus	58-68
14577597-1	2003	The norepinephrine (NE)-induced hypertrophy of the left ventricle (LV) in the rat is preceded by increased interleukin (IL)-6 expression and associated with LV fibrosis.	Norepinephrine	4-18	interleukin 6	Rattus norvegicus	107-125
14512099-5	2003	These vessels, prepared from SHR or WKY rats treated orally with NCX 4016 (10, 30 and 100 micromol/kg for 7 consecutive days), revealed a dose-dependent decrease in vasoconstriction in response to transmural nerve stimulation and norepinephrine, whereas aspirin was ineffective.	Norepinephrine	230-244	solute carrier family 8 member A1	Rattus norvegicus	65-68
14629744-6	2003	In the perfusion fluid of preparations incubated with phenylephrine, a concentration-dependent increase of noradrenaline was observed which was reversed by L-NMMA and restored when SIN-1 was added together with the nitric oxide synthase inhibitor.	Norepinephrine	107-120	MAPK associated protein 1	Homo sapiens	181-186
12925902-8	2003	The norepinephrine dosage used in the ICU correlated with plasma IL-8 levels 2 hours after arriving in the ICU (r = 0.56, p = 0.031).	Norepinephrine	4-18	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
12900383-9	2003	In addition, treatment of calvaria with isoprenaline or norepinephrine increased IL-6 synthesis in the organ culture system.	Norepinephrine	56-70	interleukin 6	Mus musculus	81-85
14523327-0	2003	Norepinephrine infusion increases interleukin-6 in plasma and cerebrospinal fluid of brain-injured rats.	Norepinephrine	0-14	interleukin 6	Rattus norvegicus	34-47
14523327-10	2003	Norepinephrine infusion significantly increased plasma IL-6 at 7 and 27 hours after TBI; IL-6 was significantly elevated in CSF only at 7 hours (p<0.05).	Norepinephrine	0-14	interleukin 6	Rattus norvegicus	55-59
14523327-12	2003	CONCLUSIONS: The norepinephrine-induced increase in plasma and CSF IL-6 suggests that concomitant norepinephrine administration needs to be considered when interpreting systemic and local changes in IL-6 levels in TBI patients.	Norepinephrine	17-31	interleukin 6	Homo sapiens	67-71
14523327-12	2003	CONCLUSIONS: The norepinephrine-induced increase in plasma and CSF IL-6 suggests that concomitant norepinephrine administration needs to be considered when interpreting systemic and local changes in IL-6 levels in TBI patients.	Norepinephrine	17-31	interleukin 6	Homo sapiens	199-203
14523327-12	2003	CONCLUSIONS: The norepinephrine-induced increase in plasma and CSF IL-6 suggests that concomitant norepinephrine administration needs to be considered when interpreting systemic and local changes in IL-6 levels in TBI patients.	Norepinephrine	98-112	interleukin 6	Homo sapiens	67-71
14519412-7	2003	administered CRH increased plasma noradrenaline and adrenaline in a dose-dependent manner (0.5, 1.5, and 3.0 nmol/animal).	Norepinephrine	34-47	corticotropin releasing hormone	Rattus norvegicus	13-16
12889599-4	2003	Our results show that met-enkephalin, substance P, bombesin, dopamine, and norepinephrine have a stimulatory effect on the migration of the breast cancer cells; moreover, these cells show positive chemotaxis towards norepinephrine as was analyzed by the directionality and persistence on a single-cell basis.	Norepinephrine	216-230	proopiomelanocortin	Homo sapiens	22-36
12886028-1	2003	Pineal gland G-protein coupled P2Y(1) receptors potentiate noradrenaline-induced N"-acetylserotonin production, a long term response which occurs after 5 h incubation.	Norepinephrine	59-72	purinergic receptor P2Y1	Rattus norvegicus	31-37
12887693-1	2003	Re-uptake of the neurotransmitters serotonin and noradrenaline out of the synaptic cleft is mediated by selective transporter proteins, the serotonin transporter and the noradrenaline transporter respectively.	Norepinephrine	49-62	solute carrier family 6 member 4	Homo sapiens	140-161
12764077-1	2003	In the adrenergic system, release of the neurotransmitter norepinephrine from sympathetic nerves is regulated by presynaptic inhibitory alpha2-adrenoceptors, but it is unknown whether release of epinephrine from the adrenal gland is controlled by a similar short feedback loop.	Norepinephrine	58-72	adrenergic receptor, alpha 2a	Mus musculus	136-156
12950455-0	2003	Noradrenaline enhances monocarboxylate transporter 2 expression in cultured mouse cortical neurons via a translational regulation.	Norepinephrine	0-13	solute carrier family 16 (monocarboxylic acid transporters), member 7	Mus musculus	23-52
12950455-3	2003	Treatment of cultured cortical neurons with 100 microm noradrenaline (NA) led, after a few hours, to a striking enhancement in fluorescence intensity associated with MCT2 IR in the cell soma as well as in dendrites.	Norepinephrine	55-68	solute carrier family 16 (monocarboxylic acid transporters), member 7	Mus musculus	166-170
12858360-0	2003	Norepinephrine activates P44 and P42 MAPK in human prostate stromal and smooth muscle cells but not in epithelial cells.	Norepinephrine	0-14	mitogen-activated protein kinase 1	Homo sapiens	33-41
12851603-6	2003	Vasopressin also appears to adversely effect hemodynamics and cardiac remodeling, while potentiating the effects of norepinephrine and angiotensin II.	Norepinephrine	116-130	arginine vasopressin	Homo sapiens	0-11
12889599-4	2003	Our results show that met-enkephalin, substance P, bombesin, dopamine, and norepinephrine have a stimulatory effect on the migration of the breast cancer cells; moreover, these cells show positive chemotaxis towards norepinephrine as was analyzed by the directionality and persistence on a single-cell basis.	Norepinephrine	216-230	tachykinin precursor 1	Homo sapiens	38-49
12845422-2	2003	Denervated vas deferens was approximately 22 times more sensitive to noradrenaline (pD(2)=7.35+/-0.04) than control vas (pD(2)=6.01+/-0.03).	Norepinephrine	69-82	arginine vasopressin	Rattus norvegicus	11-14
12829196-3	2003	We hypothesized that in normal veins, vasodilator prostaglandins contribute significantly to ACE inhibitor dilation of norepinephrine-induced venoconstriction, and this would be blocked by cyclooxygenase inhibition.	Norepinephrine	119-133	angiotensin I converting enzyme	Homo sapiens	93-96
12817186-0	2003	Regional norepinephrine spillover in response to angiotensin-converting enzyme inhibition in healthy subjects.	Norepinephrine	9-23	angiotensin I converting enzyme	Homo sapiens	49-78
12817189-3	2003	METHODS AND RESULTS: In rat isolated kidney Ang I, Ang II, Ang III, Ang IV and des-Asp-Ang I induced pressor responses and enhanced noradrenaline release to renal nerve stimulation (RNS) in an concentration-dependent manner, with the following rank order of potency (EC(50)): Ang II >or= Ang III > Ang I = des-Asp-Ang I > Ang IV.	Norepinephrine	132-145	angiotensinogen	Rattus norvegicus	51-57
12817189-3	2003	METHODS AND RESULTS: In rat isolated kidney Ang I, Ang II, Ang III, Ang IV and des-Asp-Ang I induced pressor responses and enhanced noradrenaline release to renal nerve stimulation (RNS) in an concentration-dependent manner, with the following rank order of potency (EC(50)): Ang II >or= Ang III > Ang I = des-Asp-Ang I > Ang IV.	Norepinephrine	132-145	angiotensinogen	Rattus norvegicus	59-65
12817189-9	2003	CONCLUSION: Ang I, Ang II, Ang III, Ang IV and des-Asp-Ang I regulate renal vascular resistance and noradrenaline release by activation of AT(1) receptors.	Norepinephrine	100-113	angiotensinogen	Rattus norvegicus	19-25
12845422-3	2003	This difference in noradrenaline potency was eliminated when cocaine (6 microM) was added to control vas (pD(2)=7.22+/-0.04).	Norepinephrine	19-32	arginine vasopressin	Rattus norvegicus	101-104
14552557-4	2003	Corticoliberin increased dopamine and noradrenaline levels in the hypothalamus of both rat lines, with significant decreases in the striatum.	Norepinephrine	38-51	corticotropin releasing hormone	Rattus norvegicus	0-14
12845422-4	2003	The noradrenaline-induced contractions of control and denervated vas deferens were insensitive to the alpha(1B)/alpha(1D)-adrenoceptor alkylating agent chloroethylclonidine (100 microM, 45 min).	Norepinephrine	4-17	arginine vasopressin	Rattus norvegicus	65-68
12845422-7	2003	We conclude that noradrenaline-induced contractions in control and denervated rat vas deferens are mediated by alpha(1A)-adrenoceptors and that surgical denervation of the rat vas deferens is not able to change the alpha(1)-adrenoceptor subtypes involved in the contractions to noradrenaline.	Norepinephrine	17-30	arginine vasopressin	Rattus norvegicus	82-85
12833238-5	2003	From a biochemical point of view, glutamate and substance P receptors, as well as the main systems involved in the transmission of pain, serotonin and noradrenaline, seem to play a fundamental role.	Norepinephrine	151-164	tachykinin precursor 1	Homo sapiens	48-59
12733076-2	2003	infusion of norepinephrine in rats has been shown to induce early interleukin (IL)-6 mRNA expression in the left ventricle (LV) which was followed by hypertrophy and fibrosis.	Norepinephrine	12-26	interleukin 6	Rattus norvegicus	66-84
12700679-1	2003	The neuropeptide galanin coexists with norepinephrine and serotonin in neural systems mediating emotion.	Norepinephrine	39-53	galanin and GMAP prepropeptide	Mus musculus	17-24
12766641-12	2003	CONCLUSIONS: In patients who received long-term treatment with renin-angiotensin system inhibitors, intraoperative refractory arterial hypotension was corrected with both terlipressin and norepinephrine.	Norepinephrine	188-202	renin	Homo sapiens	63-68
12791828-7	2003	RESULTS: hNET-expressing hepatoma cell lines accumulated up to 36 times more norepinephrine than did wild-type cells and 8 times more than did hNET-expressing neuroblastoma cell line SK-N-SH.	Norepinephrine	77-91	solute carrier family 6 member 2	Homo sapiens	9-13
12791828-12	2003	CONCLUSION: Transduction of the hNET gene enables Morris hepatoma cells to accumulate norepinephrine and MIBG.	Norepinephrine	86-100	solute carrier family 6 member 2	Homo sapiens	32-36
12805287-1	2003	The norepinephrine transporter (NET) mediates reuptake of norepinephrine released from neurons, and, as such, it is an important regulator of noradrenergic neurotransmission.	Norepinephrine	4-18	solute carrier family 6 member 2	Homo sapiens	32-35
12859859-6	2003	Additionally, circulating IL-6 was also significantly correlated with plasma norepinephrine (r = 0.86, p < 0.001) and right atrial pressure (r = 0.57, p < 0.01).	Norepinephrine	77-91	interleukin 6	Homo sapiens	26-30
12787829-0	2003	Nantenine blocks muscle contraction and Ca2+ transient induced by noradrenaline and K+ in rat vas deferens.	Norepinephrine	66-79	arginine vasopressin	Rattus norvegicus	94-97
12718440-3	2003	One cuproprotein, dopamine beta-hydroxylase (DBH) functions in the biosynthesis of norepinephrine and epinephrine, neurohormones in endocrine and nervous tissue.	Norepinephrine	83-97	dopamine beta hydroxylase	Mus musculus	18-43
12718440-3	2003	One cuproprotein, dopamine beta-hydroxylase (DBH) functions in the biosynthesis of norepinephrine and epinephrine, neurohormones in endocrine and nervous tissue.	Norepinephrine	83-97	dopamine beta hydroxylase	Mus musculus	45-48
12718440-6	2003	In addition to the lower level of enzyme, the products of DBH catalytic activity, norepinephrine and epinephrine, are also decreased.	Norepinephrine	82-96	dopamine beta hydroxylase	Mus musculus	58-61
12726820-1	2003	alpha(2)-ARs regulate brain monoaminergic function by inhibiting neuronal firing and release of monoamine neurotransmitters, noradrenaline (NA), serotonin (5-HT) and dopamine (DA).	Norepinephrine	125-138	adrenergic receptor, alpha 2a	Mus musculus	0-12
12729908-3	2003	We found that noradrenaline transiently induced the expression of mPer1, mPer2, and mE4bp4 1-2 h after alpha(1)-receptor activation.	Norepinephrine	14-27	period circadian clock 2	Mus musculus	73-78
12794055-5	2003	We show that 18-week-old female C57Bl/6J lpr/lpr mice, which do not show overt symptoms of the disease but already have increased IgM and IgG2a levels in the blood, have decreased noradrenaline (NA) concentration and content in the spleen, but not in the kidney, as compared to normal C57Bl/6J littermates.	Norepinephrine	180-193	Fas (TNF receptor superfamily member 6)	Mus musculus	41-44
12794055-5	2003	We show that 18-week-old female C57Bl/6J lpr/lpr mice, which do not show overt symptoms of the disease but already have increased IgM and IgG2a levels in the blood, have decreased noradrenaline (NA) concentration and content in the spleen, but not in the kidney, as compared to normal C57Bl/6J littermates.	Norepinephrine	180-193	Fas (TNF receptor superfamily member 6)	Mus musculus	45-48
12770950-4	2003	4 In arteries constricted with noradrenaline, the endothelium-dependent relaxation induced by ACh (0.01-1 micro M) was enhanced by SOD (200 U ml(-1)) (P<0.01).	Norepinephrine	31-44	superoxide dismutase 1	Homo sapiens	131-134
12697718-0	2003	Angiotensin II AT(1) and AT(2) receptors contribute to maintain basal adrenomedullary norepinephrine synthesis and tyrosine hydroxylase transcription.	Norepinephrine	86-100	angiotensinogen	Rattus norvegicus	0-14
12729939-1	2003	Angiotensin-converting enzyme (ACE) modulates dopamine turnover in the brain and catechol-O-methyltransferase (COMT) enzyme is an important agent in the metabolic inactivation of dopamine and norepinephrine.	Norepinephrine	192-206	angiotensin I converting enzyme	Homo sapiens	0-29
12729939-1	2003	Angiotensin-converting enzyme (ACE) modulates dopamine turnover in the brain and catechol-O-methyltransferase (COMT) enzyme is an important agent in the metabolic inactivation of dopamine and norepinephrine.	Norepinephrine	192-206	angiotensin I converting enzyme	Homo sapiens	31-34
12767723-1	2003	In addition to their physiological roles in the cardiovascular system (CVS), G-protein-coupled receptor (GPCR) agonists such as noradrenaline, endothelin-1 and angiotensin II (Ang II) are known to be involved in the development of cardiac hypertrophy.	Norepinephrine	128-141	angiotensinogen	Homo sapiens	176-182
12770950-8	2003	6 In endothelium-denuded strips constricted with noradrenaline, SOD enhanced the relaxation induced by the NO donor 1-hydroxy-2-oxo-3-(N-methyl-3-aminopropyl)-3-methyl-1-triazene (NOC-7) (P<0.05).	Norepinephrine	49-62	superoxide dismutase 1	Homo sapiens	64-67
12906374-5	2003	The interleukin-6 (IL-6) over-production can either be ascribed directly to the tumor (as confirmed by immunohistochemistry) or indirectly accounted for by tumoral production, as a consequence of the high levels of circulating norepinephrine.	Norepinephrine	227-241	interleukin 6	Homo sapiens	4-17
12906374-5	2003	The interleukin-6 (IL-6) over-production can either be ascribed directly to the tumor (as confirmed by immunohistochemistry) or indirectly accounted for by tumoral production, as a consequence of the high levels of circulating norepinephrine.	Norepinephrine	227-241	interleukin 6	Homo sapiens	19-23
12706465-4	2003	Intracerebroventricularly administered indomethacin [1.2 micromol (500 microg)/animal] (an inhibitor of cyclooxygenase) abolished the elevations of both noradrenaline and adrenaline induced by vasopressin and CRH.	Norepinephrine	153-166	arginine vasopressin	Rattus norvegicus	193-204
12742193-5	2003	The concentration and localization of dopamine beta-hydroxylase in noradrenaline-containing neurons was immunohistochemically assessed (semiquantitatively as 0, 1 and 2) with anti-dopamine beta-hydroxylase, at precisely defined sites of the hypothalamus and brain stem of the same rabbit.	Norepinephrine	67-80	dopamine beta-hydroxylase	Oryctolagus cuniculus	38-63
12706465-5	2003	Intracerebroventricularly administered furegrelate [1.8 micromol (500 microg)/animal] (an inhibitor of thromboxane A(2) synthase) abolished the elevations of both noradrenaline and adrenaline induced by vasopressin, while the reagent only attenuated the elevation of plasma adrenaline evoked by CRH.	Norepinephrine	163-176	arginine vasopressin	Rattus norvegicus	203-214
12706465-2	2003	The present study was designed to characterize the source of plasma noradrenaline induced by centrally administered vasopressin and corticotropin-releasing hormone (CRH) in urethane-anesthetized rats.	Norepinephrine	68-81	arginine vasopressin	Rattus norvegicus	116-127
12706465-2	2003	The present study was designed to characterize the source of plasma noradrenaline induced by centrally administered vasopressin and corticotropin-releasing hormone (CRH) in urethane-anesthetized rats.	Norepinephrine	68-81	corticotropin releasing hormone	Rattus norvegicus	132-163
12706465-6	2003	Acute bilateral adrenalectomy abolished the elevation of both noradrenaline and adrenaline induced by vasopressin, while the procedure reduced only the elevation of adrenaline induced by CRH.	Norepinephrine	62-75	arginine vasopressin	Rattus norvegicus	102-113
12706465-2	2003	The present study was designed to characterize the source of plasma noradrenaline induced by centrally administered vasopressin and corticotropin-releasing hormone (CRH) in urethane-anesthetized rats.	Norepinephrine	68-81	corticotropin releasing hormone	Rattus norvegicus	165-168
12706465-3	2003	Intracerebroventricularly administered vasopressin (0.2 nmol/animal) and CRH (1.5 nmol/animal) elevated plasma levels of noradrenaline and adrenaline.	Norepinephrine	121-134	arginine vasopressin	Rattus norvegicus	39-50
12706465-8	2003	The vasopressin-induced noradrenaline release from adrenal medulla is mediated by brain thromboxane A(2)-mediated mechanisms, while the CRH-induced noradrenaline release from sympathetic nerves is mediated by brain prostanoid (other than thromboxane A(2))-mediated mechanisms.	Norepinephrine	24-37	arginine vasopressin	Rattus norvegicus	4-15
12706465-3	2003	Intracerebroventricularly administered vasopressin (0.2 nmol/animal) and CRH (1.5 nmol/animal) elevated plasma levels of noradrenaline and adrenaline.	Norepinephrine	121-134	corticotropin releasing hormone	Rattus norvegicus	73-76
12706465-8	2003	The vasopressin-induced noradrenaline release from adrenal medulla is mediated by brain thromboxane A(2)-mediated mechanisms, while the CRH-induced noradrenaline release from sympathetic nerves is mediated by brain prostanoid (other than thromboxane A(2))-mediated mechanisms.	Norepinephrine	148-161	corticotropin releasing hormone	Rattus norvegicus	136-139
12679149-4	2003	In vessels from NOS-3 knockout mice, noradrenaline contractions consisted of an early steeply rising phase with a later shallow rising phase to a maximum (10.21+/-0.84 mN), which was significantly greater than in wild-type and NOS-2 knockout mice, and resembled the contraction to phenylephrine (10 microM) in wild-type.	Norepinephrine	37-50	nitric oxide synthase 2, inducible	Mus musculus	227-232
12648160-3	2003	The importance of COX-2 in the regulation of renal haemodynamics seems to be dependent on the endogenous production of other vasoactive products such as nitric oxide (NO) or noradrenaline.	Norepinephrine	174-187	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-23
12714206-9	2003	Plasma norepinephrine and interleukin-6 levels were increased in patients with higher CRP levels, suggesting a possible role of sympathetic activation and enhanced immune response in the development of LV remodeling after AMI.	Norepinephrine	7-21	C-reactive protein	Homo sapiens	86-89
12644277-0	2003	Drinking attenuates the noradrenaline release in the lateral hypothalamic area induced by angiotensin II activation of the subfornical organ in rats.	Norepinephrine	24-37	angiotensinogen	Rattus norvegicus	90-104
12746566-3	2003	The expression of phenylethanolamine-N-methyltransferase (PNMT), the enzyme responsible for production of epinephrine from norepinephrine, is common to both mouse and human pheochromocytomas.	Norepinephrine	123-137	phenylethanolamine-N-methyltransferase	Mus musculus	18-56
12746566-3	2003	The expression of phenylethanolamine-N-methyltransferase (PNMT), the enzyme responsible for production of epinephrine from norepinephrine, is common to both mouse and human pheochromocytomas.	Norepinephrine	123-137	phenylethanolamine-N-methyltransferase	Mus musculus	58-62
12642362-5	2003	However, in the latter, the specific COX-2 inhibitor N-(2-cyclohexyloxy-4-nitrophenyl) methanesulfonamide significantly attenuated norepinephrine-induced vasoconstriction.	Norepinephrine	131-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
12628868-6	2003	RESULTS: There was a significant inverse linear correlation between increased circulating levels of TNF, TNF receptors, and norepinephrine for time-domain and frequency-domain indexes of heart rate variability among patients with heart failure and control subjects.	Norepinephrine	124-138	tumor necrosis factor	Homo sapiens	100-103
12605405-6	2003	This study indicates that serotonin and noradrenaline stimulate AVP and VIP expression, and could participate in the differentiation of the neurochemical phenotype in the mouse SCN.	Norepinephrine	40-53	vasoactive intestinal polypeptide	Mus musculus	72-75
12645718-6	2003	After CPB, the vasopressin group had a lower peak norepinephrine dose than the placebo group (4.6 +/- 2.5 versus 7.3 +/- 3.5 microg/min, p = 0.03), a shorter period on catecholamines (5 +/- 6 versus 11 +/- 7 hours, p = 0.03), fewer hypotensive episodes (1 +/- 1 versus 4 +/- 2, p < 0.01), and a shorter intensive care unit length of stay (1.2 +/- 0.4 versus 2.1 +/- 1.4 days, p = 0.03).	Norepinephrine	50-64	arginine vasopressin	Homo sapiens	15-26
12644001-3	2003	AIMS: We tested the hypothesis that hypoxia (HX), angiotensin-II (A-II) and norepinephrine (NEPI) can mediate apoptosis by activating p38 MAPK, and thus initiating stimulus specific changes in Fas-L and cyclin D(1) expression in failing cardiomyocytes.	Norepinephrine	76-90	cyclin D1	Canis lupus familiaris	203-214
12609747-0	2003	Angiotensin II-induced release of oxytocin: interaction with norepinephrine and role in lactation.	Norepinephrine	61-75	angiotensinogen	Homo sapiens	0-14
12609747-8	2003	These data demonstrate that Ang II evoked OT release is mediated through activation of both AT1 and AT2 receptors and suggest that a component of Ang II-induced OT stimulation is due to norepinephrine release.	Norepinephrine	186-200	angiotensinogen	Homo sapiens	146-152
12605405-1	2003	We studied the effects of serotonin and noradrenaline on the expression of arginine-vasopressin (AVP) and vasoactive intestinal peptide (VIP) in the suprachiasmatic nucleus (SCN).	Norepinephrine	40-53	vasoactive intestinal polypeptide	Mus musculus	137-140
12620376-9	2003	The enhancing effect of iNOS synthesis by epinephrine and norepinephrine on LPS-induced macrophages was down regulated by beta-adrenoceptor antagonist, propranolol, and dexamethasone.	Norepinephrine	58-72	nitric oxide synthase 2, inducible	Mus musculus	24-28
14565536-7	2003	The postsynaptic effect of AVP on the sympathetic nervous system was investigated by exposing the vessels to exogenous noradrenaline.	Norepinephrine	119-132	arginine vasopressin	Rattus norvegicus	27-30
12708746-1	2003	The norepinephrine (NE)-induced hypertrophy of the left ventricle (LV) in the rat is associated with increased interleukin (IL)-6 and IL-1beta expression.	Norepinephrine	4-18	interleukin 1 beta	Rattus norvegicus	134-142
12578963-9	2003	Only noradrenaline resulted in a dose- and time-dependent induction of NF-kappaB and NF-kappaB-dependent gene expression, which depended on pertussis-toxin-sensitive G protein-mediated phosphophatidylinositol 3-kinase, Ras/Raf, and mitogen-activated protein kinase activation.	Norepinephrine	5-18	nuclear factor kappa B subunit 1	Homo sapiens	71-80
12578963-9	2003	Only noradrenaline resulted in a dose- and time-dependent induction of NF-kappaB and NF-kappaB-dependent gene expression, which depended on pertussis-toxin-sensitive G protein-mediated phosphophatidylinositol 3-kinase, Ras/Raf, and mitogen-activated protein kinase activation.	Norepinephrine	5-18	nuclear factor kappa B subunit 1	Homo sapiens	85-94
12578963-11	2003	Thus, noradrenaline-dependent adrenergic stimulation results in activation of NF-kappaB in vitro and in vivo.	Norepinephrine	6-19	nuclear factor kappa B subunit 1	Homo sapiens	78-87
14565536-16	2003	Vasoconstriction induced by exogenous noradrenaline could be facilitated by a sub-pressor concentration of AVP and this selective postsynaptic effect could be antagonized by V1-receptor blockade.	Norepinephrine	38-51	arginine vasopressin	Rattus norvegicus	107-110
12594587-10	2003	In FHF, the specific COX-2 inhibitor, N-(2-cyclohexyloxy-4-nitrophenyl) methanesulfonamide (1 micro m/l), but not L-NAME, significantly enhanced the maximal effect ( p<0.01) and the sensitivity ( p<0.01) to norepinephrine.	Norepinephrine	213-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
12581166-1	2003	Galanin and galanin receptors are widely expressed by neurons in rat brain that either synthesize/release and/or are responsive to, classical transmitters such as gamma-aminobutyric acid, acetylcholine, noradrenaline, histamine, dopamine and serotonin (5-hydroxytryptamine, 5-HT).	Norepinephrine	203-216	galanin and GMAP prepropeptide	Mus musculus	0-7
12581166-1	2003	Galanin and galanin receptors are widely expressed by neurons in rat brain that either synthesize/release and/or are responsive to, classical transmitters such as gamma-aminobutyric acid, acetylcholine, noradrenaline, histamine, dopamine and serotonin (5-hydroxytryptamine, 5-HT).	Norepinephrine	203-216	galanin and GMAP prepropeptide	Mus musculus	12-19
12606256-3	2003	In reserpine-treated rats (97% decrease in endogenous norepinephrine content of the heart), the amplitude of the transient outward current was decreased by 48% and Kv4.2 and Kv4.3 mRNA levels were decreased by 57% and 34%, respectively.	Norepinephrine	54-68	potassium voltage-gated channel subfamily D member 3	Rattus norvegicus	174-179
12690638-5	2003	Since the CVS-induced modulation of CRH levels are consistent with an alteration of tyrosine hydroxylase levels in the locus coeruleus, CRH-norepinephrine (NE) interaction in the terminal projection of forebrain NE systems, PVN, BNST and CeA where NE stimulates CRII release, might contribute to the bi-directional change in CRH.	Norepinephrine	140-154	corticotropin releasing hormone	Rattus norvegicus	136-139
12690638-5	2003	Since the CVS-induced modulation of CRH levels are consistent with an alteration of tyrosine hydroxylase levels in the locus coeruleus, CRH-norepinephrine (NE) interaction in the terminal projection of forebrain NE systems, PVN, BNST and CeA where NE stimulates CRII release, might contribute to the bi-directional change in CRH.	Norepinephrine	140-154	corticotropin releasing hormone	Rattus norvegicus	136-139
12538816-6	2003	In the same manner, salbutanol and terbutaline as well as norepinephrine, epinephrine, and isoproterenol regulated the IL-18-induced cytokine production, including IL-12, tumor necrosis factor-alpha or interferon-gamma through the stimulation of beta 2-AR.	Norepinephrine	58-72	interferon gamma	Homo sapiens	202-218
12559381-2	2003	In both portions, noradrenaline-elicited contractions were enhanced by the adenosine A(1) receptor agonist N(6)-cyclopentyladenosine (CPA), and inhibited by the non-selective adenosine receptor agonist 5"-N-ethylcarboxamidoadenosine (NECA) in the presence of the adenosine A(1) receptor antagonist 1,3-dipropyl-8-cyclopentyl-l,3-dipropylxanthine (DPCPX).	Norepinephrine	18-31	adenosine A1 receptor	Rattus norvegicus	75-98
12559381-2	2003	In both portions, noradrenaline-elicited contractions were enhanced by the adenosine A(1) receptor agonist N(6)-cyclopentyladenosine (CPA), and inhibited by the non-selective adenosine receptor agonist 5"-N-ethylcarboxamidoadenosine (NECA) in the presence of the adenosine A(1) receptor antagonist 1,3-dipropyl-8-cyclopentyl-l,3-dipropylxanthine (DPCPX).	Norepinephrine	18-31	adenosine A1 receptor	Rattus norvegicus	263-286
12891655-1	2003	Tyrosine hydroxylase (TH) is the key enzyme in the biosynthesis of the catecholamines dopamine, epinephrine, and norepinephrine.	Norepinephrine	113-127	tyrosine hydroxylase	Homo sapiens	0-20
14570150-0	2003	The effects of peptide and nonpeptide antagonists of angiotensin II receptors on the noradrenaline uptake of different brain structures in rats with angiotensin II-induced increase of water intake.	Norepinephrine	85-98	angiotensinogen	Rattus norvegicus	53-67
14570150-0	2003	The effects of peptide and nonpeptide antagonists of angiotensin II receptors on the noradrenaline uptake of different brain structures in rats with angiotensin II-induced increase of water intake.	Norepinephrine	85-98	angiotensinogen	Rattus norvegicus	149-163
14570150-1	2003	Angiotensin II (ANG II) significantly increased noradrenaline (NA) uptake by cortical, hypothalamic and hippocampal synaptosomes thus activating noradrenergic neurotransmission.	Norepinephrine	48-61	angiotensinogen	Rattus norvegicus	0-14
14570150-1	2003	Angiotensin II (ANG II) significantly increased noradrenaline (NA) uptake by cortical, hypothalamic and hippocampal synaptosomes thus activating noradrenergic neurotransmission.	Norepinephrine	48-61	angiotensinogen	Rattus norvegicus	16-22
15166499-8	2003	These data suggest that norepinephrine stimulates myocardial angiogenesis by a paracrine mechanism that involves cardiac non-myocytes and TGF beta.	Norepinephrine	24-38	transforming growth factor, beta 1	Rattus norvegicus	138-146
12891655-1	2003	Tyrosine hydroxylase (TH) is the key enzyme in the biosynthesis of the catecholamines dopamine, epinephrine, and norepinephrine.	Norepinephrine	113-127	tyrosine hydroxylase	Homo sapiens	22-24
12688404-3	2003	In the presence of 100 nM norepinephrine, endothelin-1 (10 nM) and carbachol (30 nM) decreased the norepinephrine-induced positive inotropic effect to about 40% of the norepinephrine-induced maximal response.	Norepinephrine	99-113	endothelin 1	Canis lupus familiaris	42-54
14677757-4	2003	As a sympathetic co-transmitter NPY causes vasoconstriction, stimulates vascular growth and potentiates the contractile activity of noradrenaline (NA), and as a parasympathetic neurotransmitter it is involved in the regulation of vasodilatation within e.g. the uterine artery.	Norepinephrine	132-145	neuropeptide Y	Sus scrofa	32-35
12688404-3	2003	In the presence of 100 nM norepinephrine, endothelin-1 (10 nM) and carbachol (30 nM) decreased the norepinephrine-induced positive inotropic effect to about 40% of the norepinephrine-induced maximal response.	Norepinephrine	26-40	endothelin 1	Canis lupus familiaris	42-54
12688404-3	2003	In the presence of 100 nM norepinephrine, endothelin-1 (10 nM) and carbachol (30 nM) decreased the norepinephrine-induced positive inotropic effect to about 40% of the norepinephrine-induced maximal response.	Norepinephrine	99-113	endothelin 1	Canis lupus familiaris	42-54
12686728-3	2003	The inhibitory effect of endothelin-1 (3 x 10(-)(9) M) on noradrenaline release was abolished by BQ-123 (a selective antagonist of endothelin ET(A) receptors) in a dose-dependent manner (10(-)(7) and 10(-)(6) M), but not influenced by BQ-788 (a selective antagonist of endothelin ET(B) receptors) (10(-)(7) and 10(-)(6) M).	Norepinephrine	58-71	endothelin 1	Rattus norvegicus	25-37
12686728-4	2003	The endothelin-1-induced inhibition of noradrenaline release was attenuated by pretreatment with pertussis toxin (10 micro g/animal, i.v., 4 days before experiments), but not influenced by indomethacin (3 x 10(-)(6) M).	Norepinephrine	39-52	endothelin 1	Rattus norvegicus	4-16
12444301-1	2003	Chronic surgical denervation of the rat vas deferens leads to an enhanced contractile response of the tissue to norepinephrine in vitro.	Norepinephrine	112-126	arginine vasopressin	Rattus norvegicus	40-43
12617949-3	2003	The present study examines whether corticotropin-releasing hormone contributes to stress-evoked increases in extracellular norepinephrine and dopamine in rat medial prefrontal cortex, as monitored by in vivo microdialysis.	Norepinephrine	123-137	corticotropin releasing hormone	Rattus norvegicus	35-66
12617949-6	2003	Intraventricular administration of 3 microg of D-Phe-corticotropin-releasing hormone attenuated the increase in extracellular norepinephrine induced by co-administration of 3 microg of corticotropin-releasing hormone, confirming the efficacy of this compound.	Norepinephrine	126-140	corticotropin releasing hormone	Rattus norvegicus	53-84
12617949-6	2003	Intraventricular administration of 3 microg of D-Phe-corticotropin-releasing hormone attenuated the increase in extracellular norepinephrine induced by co-administration of 3 microg of corticotropin-releasing hormone, confirming the efficacy of this compound.	Norepinephrine	126-140	corticotropin releasing hormone	Rattus norvegicus	185-216
12619890-0	2003	Regulation of norepinephrine-induced proliferation in cardiac fibroblasts by interleukin-6 and p42/p44 mitogen activated protein kinase.	Norepinephrine	14-28	interleukin 6	Rattus norvegicus	77-90
12460640-3	2002	administered vasopressin (0.1, 0.2 and 0.5 nmol/animal) dose-dependently elevated plasma levels of adrenaline and noradrenaline (adrenaline>noradrenaline).	Norepinephrine	114-127	arginine vasopressin	Rattus norvegicus	13-24
14568031-3	2003	Tumor necrosis factor-alpha was infused into the basal forebrain of young mice pretreated with a norepinephrine neuronal toxin, N-(2-chloroethyl)-N-ethyl-2 bromobenzylamine (DSP4), with the expectation that the loss of noradrenergic input would enhance the loss of cholinergic neurons.	Norepinephrine	97-111	tumor necrosis factor	Mus musculus	0-27
12460640-3	2002	administered vasopressin (0.1, 0.2 and 0.5 nmol/animal) dose-dependently elevated plasma levels of adrenaline and noradrenaline (adrenaline>noradrenaline).	Norepinephrine	143-156	arginine vasopressin	Rattus norvegicus	13-24
12480495-5	2002	Central nervous system norepinephrine may also induce the APR perhaps by macrophage activation and cytokine release.	Norepinephrine	23-37	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	58-61
12375271-4	2002	It has recently been demonstrated that the beta(3)-adrenergic receptor is the functionally relevant adrenergic receptor subtype in brown adipocytes and that its stimulation by noradrenaline (NA) modulates the expression of genes, such as uncoupling protein (UCP)-1 and inducible nitric oxide synthase (iNOS), involved in fat cell proliferation and differentiation.	Norepinephrine	176-189	nitric oxide synthase 2	Homo sapiens	269-300
12447527-1	2002	OBJECTIVE: To test whether norepinephrine (NE) infusion at 0.4 microg kg(-1) min(-1) adversely affects regional blood flow in the normal mammalian circulation.	Norepinephrine	27-41	CD59 molecule (CD59 blood group)	Homo sapiens	77-83
12401556-2	2002	At the cellular level, functional noradrenergic neurotransmission depends on synaptic reuptake of norepinephrine as mediated by the norepinephrine transporter (NET).	Norepinephrine	98-112	solute carrier family 6 member 2	Homo sapiens	132-158
12401556-2	2002	At the cellular level, functional noradrenergic neurotransmission depends on synaptic reuptake of norepinephrine as mediated by the norepinephrine transporter (NET).	Norepinephrine	98-112	solute carrier family 6 member 2	Homo sapiens	160-163
12489810-0	2002	Activation of a renin-angiotensin system in ischemic cardiac sympathetic nerve endings and its association with norepinephrine release.	Norepinephrine	112-126	renin	Homo sapiens	16-21
12464448-11	2002	In contrast, 5-HTT-/- mice retained sensitivity to the anti-immobility effects of the norepinephrine reuptake inhibitor, desipramine (20 mg/kg), and the mixed serotonin/norepinephrine reuptake inhibitor, imipramine (25 mg/kg).	Norepinephrine	86-100	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	13-18
12464448-11	2002	In contrast, 5-HTT-/- mice retained sensitivity to the anti-immobility effects of the norepinephrine reuptake inhibitor, desipramine (20 mg/kg), and the mixed serotonin/norepinephrine reuptake inhibitor, imipramine (25 mg/kg).	Norepinephrine	169-183	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	13-18
12433597-9	2002	administered interleukin-1beta (100 ng/animal) elevated plasma levels of noradrenaline but not adrenaline.	Norepinephrine	73-86	interleukin 1 beta	Rattus norvegicus	13-30
12463096-9	2002	Multivariate analysis suggested that NKA-Abs was an independent risk factor for the occurrence of paroxysmal atrial fibrillation (p < 0.01), although there were no differences in other clinical factors: age, sex, New York Heart Association functional class, concomitant medication, left ventricular ejection fraction, left atrial diameter, severity of mitral regurgitation, serum potassium, plasma norepinephrine, and atrial natriuretic peptide concentration.	Norepinephrine	401-415	tachykinin precursor 1	Homo sapiens	37-40
12375271-4	2002	It has recently been demonstrated that the beta(3)-adrenergic receptor is the functionally relevant adrenergic receptor subtype in brown adipocytes and that its stimulation by noradrenaline (NA) modulates the expression of genes, such as uncoupling protein (UCP)-1 and inducible nitric oxide synthase (iNOS), involved in fat cell proliferation and differentiation.	Norepinephrine	176-189	nitric oxide synthase 2	Homo sapiens	302-306
12491807-1	2002	Following exocytotic release, the biogenic amine neurotransmitters, norepinephrine, dopamine, and serotonin are removed from the synaptic cleft by the respective transporter, NET, DAT, and SERT, located on the plasma membrane and then re-stored into synaptic vesicles by vesicular monoamine transporter, VMAT.	Norepinephrine	68-82	solute carrier family 6 member 4	Homo sapiens	189-193
12512959-5	2002	High concentrations of MT1 reversibly blocked responses of vas deferens to noradrenaline.	Norepinephrine	75-88	metallothionein 1	Rattus norvegicus	23-26
12391266-0	2002	Activation of the mitogen-activated protein kinase (ERK(1/2)) signaling pathway by cyclic AMP potentiates the neuroprotective effect of the neurotransmitter noradrenaline on dopaminergic neurons.	Norepinephrine	157-170	mitogen-activated protein kinase 3	Homo sapiens	52-59
12391266-1	2002	We have shown previously that low concentrations of noradrenaline (NA) confer long-term but partial protection to tyrosine hydroxylase (TH(+)) dopaminergic neurons by reducing spontaneously occurring oxidative stress.	Norepinephrine	52-65	tyrosine hydroxylase	Homo sapiens	114-134
12423672-6	2002	Norepinephrine, an alpha1 agonist phenylephrine, a beta1 agonist dobutamine and terbutaline suppressed the expressions of mRNAs encoding pro-inflammatory cytokines, interleukin-6 and tumor necrosis factor alpha.	Norepinephrine	0-14	interleukin 6	Rattus norvegicus	165-210
12423672-7	2002	Release of tumor necrosis factor alpha and nitric oxide was suppressed by norepinephrine, phenylephrine, dobutamine and terbutaline.	Norepinephrine	74-88	tumor necrosis factor	Rattus norvegicus	11-38
12423245-2	2002	The present study examined the effect of isolation rearing on the 5-HT1A receptor-mediated modulation of dopamine (DA), 5-HT and noradrenaline (NA) release in the frontal cortex of mice.	Norepinephrine	129-142	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	66-81
12234805-1	2002	The effect of three endothelin (ET) agonists [ET-1, ET-3, and sarafotoxin (STX6C)] on the nerve stimulation-induced release of norepinephrine (NE) and neuropeptide Y-immunoreactive compounds (NPY-ir) from the perfused mesenteric arterial bed of the rat as well as the effect on perfusion pressure were examined.	Norepinephrine	127-141	endothelin 1	Rattus norvegicus	46-50
12271472-3	2002	Stimulation of beta-ARs on microglia by norepinephrine (NE) resulted in an increase in the level of intracellular cAMP and the subsequent expression of interleukin-1beta mRNA.	Norepinephrine	40-54	interleukin 1 beta	Rattus norvegicus	152-169
12242714-1	2002	There are three subtypes of alpha2 adrenoceptor, i.e., alpha2A, alpha2B, and alpha2C, mediating the specific effect of epinephrine and norepinephrine in various tissues by means of G protein-coupled signal transduction pathways.	Norepinephrine	135-149	adrenergic receptor, alpha 2a	Mus musculus	55-62
12239106-9	2002	In contrast, norepinephrine and its precursor dopamine extracted from brown adipose tissue are present at significantly lower levels in the PACAP null mice compared with controls.	Norepinephrine	13-27	adenylate cyclase activating polypeptide 1	Mus musculus	140-145
12239106-10	2002	Also, PACAP null mice showed a greater loss of core body temperature compared with wild-type controls at 21 C. We conclude that under prolonged but mild cold stress, lack of PACAP results in inadequate heat production due to insufficient norepinephrine stimulation of brown adipose tissue.	Norepinephrine	238-252	adenylate cyclase activating polypeptide 1	Mus musculus	6-11
12352328-1	2002	ACE-inhibitors and AT -receptor antagonists may exert part of their pharmacological actions by interference with angiotensin-and/or bradykinin-mediated prejunctional stimulation of cardiac norepinephrine release.	Norepinephrine	189-203	angiotensin I converting enzyme	Rattus norvegicus	0-3
12352328-6	2002	Under nonischemic conditions, the ACE-inhibitor slightly reduced norepinephrine release at the highest concentration, while the AT -receptor antagonist did not influence norepinephrine release in normoxia.	Norepinephrine	65-79	angiotensin I converting enzyme	Rattus norvegicus	34-37
12352328-9	2002	The ACE-inhibitor ramiprilat and AT -receptor antagonist candesartan enhance cardiac norepinephrine release selectively in ischemia by stimulating presynaptic bradykinin B -receptors.	Norepinephrine	85-99	angiotensin I converting enzyme	Rattus norvegicus	4-7
12084707-7	2002	Additionally, Western blot analysis for phospho-CREB/ATF1 shows an increase in phosphorylation of CREB/ATF1 in HIB-1B cells after norepinephrine treatment.	Norepinephrine	130-144	cAMP responsive element binding protein 1	Mus musculus	98-102
12235258-4	2002	alpha(1a)-AR activation by norepinephrine increased the cytosolic Ca(2+) concentration and phosphorylated ERK1/2 in a time- and concentration-dependent manner.	Norepinephrine	27-41	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	0-8
12235258-7	2002	Norepinephrine also stimulated cAMP accumulation in transfected CHO-K1 cells in a concentration-dependent manner via alpha(1a)-ARs, which was blocked by the Ca(2+) chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid.	Norepinephrine	0-14	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	117-125
12084707-7	2002	Additionally, Western blot analysis for phospho-CREB/ATF1 shows an increase in phosphorylation of CREB/ATF1 in HIB-1B cells after norepinephrine treatment.	Norepinephrine	130-144	cAMP responsive element binding protein 1	Mus musculus	48-52
12389021-10	2002	We noted a significant inverse correlation between endothelin-1 and norepinephrine.	Norepinephrine	68-82	endothelin 1	Homo sapiens	51-63
12183018-5	2002	Norepinephrine release in the MPA of control rats increased significantly at 1530, 1600, and 1630 h paralelling an increase in LH at 1600 h. In contrast, IL-1beta treatment blocked the LH surge and the rise in norepinephrine release in the MPA.	Norepinephrine	0-14	interleukin 1 beta	Rattus norvegicus	154-162
12183018-5	2002	Norepinephrine release in the MPA of control rats increased significantly at 1530, 1600, and 1630 h paralelling an increase in LH at 1600 h. In contrast, IL-1beta treatment blocked the LH surge and the rise in norepinephrine release in the MPA.	Norepinephrine	210-224	interleukin 1 beta	Rattus norvegicus	154-162
12154105-0	2002	Norepinephrine enhances fibrosis mediated by TGF-beta in cardiac fibroblasts.	Norepinephrine	0-14	transforming growth factor, beta 1	Rattus norvegicus	45-53
12110505-7	2002	Norepinephrine, dopamine, and prostaglandin E2 can inhibit the antinatriuretic effects of VP, and changes in the actions of these autocrine and paracrine regulators may also be involved in abnormal regulation of Na+ reabsorption.	Norepinephrine	0-14	arginine vasopressin	Homo sapiens	90-92
12154105-2	2002	This study was conducted to investigate whether norepinephrine (NE) potentiates transforming growth factor-beta (TGF-beta)-induced cardiac fibrosis.	Norepinephrine	48-62	transforming growth factor, beta 1	Rattus norvegicus	113-121
12153469-1	2002	Hypotensive stress engages corticotropin-releasing factor (CRF) release within the rat locus coeruleus (LC), which activates LC neurones, initiating norepinephrine release in forebrain and activation of forebrain electroencephalographic activity.	Norepinephrine	149-163	corticotropin releasing hormone	Rattus norvegicus	27-57
12130713-1	2002	We recently reported that in the ischemic human heart, locally formed angiotensin II activates angiotensin II type 1 (AT(1)) receptors on sympathetic nerve terminals, promoting reversal of the norepinephrine transporter in an outward direction (i.e., carrier-mediated norepinephrine release).	Norepinephrine	193-207	angiotensinogen	Homo sapiens	70-84
12130713-7	2002	Thus, renin is rapidly activated during ischemia in cardiac sympathetic nerve terminals, and this process eventually culminates in angiotensin II formation, stimulation of AT(1) receptors, and carrier-mediated norepinephrine release.	Norepinephrine	210-224	renin	Homo sapiens	6-11
12130713-8	2002	Our findings uncover a novel autocrine/paracrine mechanism whereby angiotensin II, formed at adrenergic nerve endings in myocardial ischemia, elicits carrier-mediated norepinephrine release by activating adjacent AT(1) receptors.	Norepinephrine	167-181	angiotensinogen	Homo sapiens	67-81
12116187-2	2002	DOPA decarboxylase (DDC), also known as aromatic L-amino acid decarboxylase, is an enzyme involved directly in the synthesis of dopamine and serotonin and indirectly in the synthesis of noradrenaline.	Norepinephrine	186-199	dopa decarboxylase	Homo sapiens	0-18
12130668-1	2002	The cAMP-dependent protein kinase (PKA) transduces signals in the heart initiated by beta(1)-adrenergic, G-protein-coupled receptors after norepinephrine, sympathetic stimulation.	Norepinephrine	139-153	cathelicidin antimicrobial peptide	Homo sapiens	4-8
12116187-2	2002	DOPA decarboxylase (DDC), also known as aromatic L-amino acid decarboxylase, is an enzyme involved directly in the synthesis of dopamine and serotonin and indirectly in the synthesis of noradrenaline.	Norepinephrine	186-199	dopa decarboxylase	Homo sapiens	20-23
12116187-2	2002	DOPA decarboxylase (DDC), also known as aromatic L-amino acid decarboxylase, is an enzyme involved directly in the synthesis of dopamine and serotonin and indirectly in the synthesis of noradrenaline.	Norepinephrine	186-199	dopa decarboxylase	Homo sapiens	40-75
12131534-0	2002	Increased contraction to noradrenaline by vasopressin in human renal arteries.	Norepinephrine	25-38	arginine vasopressin	Homo sapiens	42-53
12131534-5	2002	RESULTS: AVP (10(-10) mol/l) and the vasopressin V1 receptor agonist [Phe2, Orn8]-vasotocin (10(-10) mol/l) produced a leftward shift of the concentration-response curve to noradrenaline (half-maximal effective concentration decreased from 1.1 x 10(-6) mol/l to 3.1 x 10(-7) mol/l).	Norepinephrine	173-186	arginine vasopressin	Homo sapiens	9-12
12131534-5	2002	RESULTS: AVP (10(-10) mol/l) and the vasopressin V1 receptor agonist [Phe2, Orn8]-vasotocin (10(-10) mol/l) produced a leftward shift of the concentration-response curve to noradrenaline (half-maximal effective concentration decreased from 1.1 x 10(-6) mol/l to 3.1 x 10(-7) mol/l).	Norepinephrine	173-186	arginine vasopressin	Homo sapiens	37-48
12131534-6	2002	The enhancement of noradrenaline-induced contractions was inhibited by the vasopressin V1 receptor antagonist d(CH2)5Tyr(Me)AVP (10-8 mol/l) and unaffected by endothelium removal or pretreatment with the inhibitor of nitric oxide (NO) synthase NG-monomethyl-l-arginine (l-NMMA).	Norepinephrine	19-32	arginine vasopressin	Homo sapiens	75-86
12131534-6	2002	The enhancement of noradrenaline-induced contractions was inhibited by the vasopressin V1 receptor antagonist d(CH2)5Tyr(Me)AVP (10-8 mol/l) and unaffected by endothelium removal or pretreatment with the inhibitor of nitric oxide (NO) synthase NG-monomethyl-l-arginine (l-NMMA).	Norepinephrine	19-32	arginine vasopressin	Homo sapiens	124-127
12131534-9	2002	CONCLUSIONS: The results demonstrate that subpressor concentrations of vasopressin potentiate the contractile effects of noradrenaline without intervention of the NO system.	Norepinephrine	121-134	arginine vasopressin	Homo sapiens	71-82
12208121-0	2002	Acute swimming stress induces changes in noradrenergic mechanisms in order to maintain the response pattern of the rat vas deferens to norepinephrine.	Norepinephrine	135-149	arginine vasopressin	Rattus norvegicus	119-122
12037376-3	2002	administered IL-1beta (100 ng/animal) effectively elevated plasma noradrenaline rather than plasma adrenaline.	Norepinephrine	66-79	interleukin 1 beta	Rattus norvegicus	13-21
12168505-8	2002	Ang II-receptor antagonists exerted mosaic effects on noradrenaline and 5-HT (serotonin) levels depending on both--the type of biogenic monoamine and the brain structure.	Norepinephrine	54-67	angiotensinogen	Rattus norvegicus	0-6
12020848-7	2002	The same doses of SIN-1 also increased the release of noradrenaline in the hypothalamic paraventricular nucleus (PVN) measuring microdialysis technique, and this increase was abolished by tetrodotoxin (1 microM) administered into the perfusion solution of the PVN.	Norepinephrine	54-67	MAPK associated protein 1	Homo sapiens	18-23
12020848-9	2002	), a cyclooxygenase inhibitor, abolished the SIN-1-induced elevations of both noradrenaline in the PVN and plasma corticosterone.	Norepinephrine	78-91	MAPK associated protein 1	Homo sapiens	45-50
12081658-1	2002	The present study investigated the role of alpha2A-adrenoceptor subtype in the regulation of noradrenaline and dopamine release in the medial prefrontal cortex.	Norepinephrine	93-106	adrenergic receptor, alpha 2a	Mus musculus	43-63
12081658-6	2002	However, the effect of dexmedetomidine on noradrenaline release was attenuated in the alpha2A-adrenoceptor knockout mice, whereas the effect on dopamine release did not differ between the genotypes.	Norepinephrine	42-55	adrenergic receptor, alpha 2a	Mus musculus	86-106
12081658-8	2002	However, in alpha2A-adrenoceptor knockout mice the noradrenaline and dopamine levels remained elevated in the samples following the first handling whilst, in the control mice, transmitter levels returned to baseline levels.	Norepinephrine	51-64	adrenergic receptor, alpha 2a	Mus musculus	12-32
12006357-4	2002	Infusion of glucose and insulin significantly amplified and/or prolonged the cardiovascular, plasma interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and counterregulatory hormone responses to LPS, whereas the effects on fever, plasma norepinephrine concentrations, and oxygen consumption were unaffected.	Norepinephrine	248-262	insulin	Homo sapiens	24-31
12184059-7	2002	In reality, renin-angiotensin actions on the sympathetic nervous system are probably much more circumscribed than this, with the case perhaps being strongest for a presynaptic action of angiotensin on sympathetic nerves, to augment noradrenaline release.	Norepinephrine	232-245	renin	Homo sapiens	12-17
12065078-8	2002	Pretreatment with the beta(1)-adrenoceptor antagonist atenolol in intact aortic rings abolished the difference in response to norepinephrine between the control and ethanol groups, which implies the involvement of a weakened beta(1)-adrenoceptor component in vessels from the ethanol-fed rats.	Norepinephrine	126-140	adrenoceptor beta 1	Rattus norvegicus	22-42
11988078-2	2002	We found that noradrenaline ("norepinephrine") stimulated CREB phosphorylation rapidly (maximum effect in < or =5 min with slow decay) and efficiently (EC(50), 6 nM).	Norepinephrine	14-27	cAMP responsive element binding protein 1	Mus musculus	58-62
11988078-2	2002	We found that noradrenaline ("norepinephrine") stimulated CREB phosphorylation rapidly (maximum effect in < or =5 min with slow decay) and efficiently (EC(50), 6 nM).	Norepinephrine	30-44	cAMP responsive element binding protein 1	Mus musculus	58-62
11959689-9	2002	Intravenous norepinephrine increased catalase activity in the heart, brain, and liver.	Norepinephrine	12-26	catalase	Oryctolagus cuniculus	37-45
12200739-2	2002	Lack of AADC leads to a combined deficiency of the catecholamines DA, norepinephrine (NE), epinephrine (E) as well as of serotonin.	Norepinephrine	70-84	dopa decarboxylase	Homo sapiens	8-12
12065078-8	2002	Pretreatment with the beta(1)-adrenoceptor antagonist atenolol in intact aortic rings abolished the difference in response to norepinephrine between the control and ethanol groups, which implies the involvement of a weakened beta(1)-adrenoceptor component in vessels from the ethanol-fed rats.	Norepinephrine	126-140	adrenoceptor beta 1	Rattus norvegicus	225-245
12009349-8	2002	RESULT(S): Low baseline levels of DA, serotonin, and beta-endorphin increased significantly (P<.001) from 181.9 +/- 47.8 pg/mL to 202.9 +/- 32.8 pg/mL (mean +/- SD); from 206.4 +/- 94.2 ng/mL to 279.2 +/- 67.9 ng/mL; from 11.2 +/- 1.8 pmol/L to 13.8 +/- 2.4 pmol/L, respectively, after conjugated equine E. In parallel, augmented baseline noradrenaline levels diminished significantly (P<.05) from 30.2 +/- 4.7 ng/mL to 24.0 +/- 4.7 ng/mL.	Norepinephrine	342-355	proopiomelanocortin	Homo sapiens	53-67
12065661-2	2002	5-HT is present in organelles distinct from l-glutamate-containing synaptic-like microvesicles as well as in the cytoplasm of pinealocytes, and is secreted upon stimulation by norepinephrine (NE) to enhance serotonin N-acetyltransferase activity via the 5-HT2 receptor.	Norepinephrine	176-190	5-hydroxytryptamine receptor 2A	Homo sapiens	254-268
11960941-4	2002	In conclusion, chronic hypobaric hypoxemia 1) elevates the set point of plasma osmolality-to-plasma vasopressin relationship, possibly because of concurrent hypertension, thereby causing hypovolemia and hyperosmolality, and 2) blunts the natriuretic response to hypertonic volume expansion, possibly because of elevated circulating levels of norepinephrine and endothelin, reduced urodilatin synthesis, or attenuated inhibition of the renin system.	Norepinephrine	342-356	arginine vasopressin	Homo sapiens	100-111
11956122-10	2002	At the highest dose (1.5 mg BID), the trough reduction in norepinephrine was 52%.	Norepinephrine	58-72	BH3 interacting domain death agonist	Homo sapiens	28-31
11978831-6	2002	Concentrations of serotonin and its metabolite, 5-hydroxyindolacetic acid, and norepinephrine were decreased markedly in the anterior and posterior cerebrum but increased in the brainstem of GAP43-/- mice.	Norepinephrine	79-93	growth associated protein 43	Mus musculus	191-196
12007924-3	2002	In diabetic but not in control aorta, the noradrenaline-induced contraction was significantly enhanced by catalase and significantly inhibited by polyethylene-glycolated superoxide dismutase.	Norepinephrine	42-55	catalase	Rattus norvegicus	106-114
12007924-5	2002	In the presence of N(G)-nitro-L-arginine, the noradrenaline-induced contraction of aorta from diabetic rats, but not from controls, was inhibited by catalase treatment.	Norepinephrine	46-59	catalase	Rattus norvegicus	149-157
11961038-5	2002	Removal of the biosynthetic enzymes tyrosine hydroxylase and dopamine-beta-hydroxylase yield animals deficient in norepinephrine and have been used to further examine the role of NE in diverse physiologic roles.	Norepinephrine	114-128	dopamine beta hydroxylase	Mus musculus	61-86
11911992-5	2002	NPY inhibited both the spontaneous activity and the excitatory effect of norepinephrine in injured DRG A-neurons.	Norepinephrine	73-87	neuropeptide Y	Rattus norvegicus	0-3
11748228-1	2002	Previously we observed that rab3 GTPases modulate both the secretion of catecholamines from PC12 neuroendocrine cells and the steady-state accumulation of exogenous norepinephrine (NE) into these cells (Weber, E., Jilling, T., and Kirk, K. L. (1996) J. Biol.	Norepinephrine	165-179	RAB3A, member RAS oncogene family	Rattus norvegicus	28-32
11955542-1	2002	Norepinephrine-resistant hypotension when associated with septic shock has a high rate of mortality, which might possibly be reduced by infusion of low-dose vasopressin.	Norepinephrine	0-14	arginine vasopressin	Homo sapiens	157-168
11996210-17	2002	PYC antagonizes the vasoconstriction caused by epinephrine and norepinephrine by increasing the activity of endothelial nitric oxide synthase.	Norepinephrine	63-77	nitric oxide synthase 3	Homo sapiens	108-141
11923423-1	2002	Expression of the norepinephrine transporter (NET), which mediates the reuptake of norepinephrine into presynaptic nerve terminals, is restricted to noradrenergic (NA) neurons.	Norepinephrine	18-32	solute carrier family 6 member 2	Homo sapiens	46-49
11919656-5	2002	The K(m) of noradrenaline was lower for hNET, rK7D, rE62K and rK375N than for rNET or rR612Q.	Norepinephrine	12-25	solute carrier family 6 member 2	Homo sapiens	40-44
11958479-0	2002	Aldose reductase: an aldehyde scavenging enzyme in the intraneuronal metabolism of norepinephrine in human sympathetic ganglia.	Norepinephrine	83-97	aldo-keto reductase family 1 member B	Homo sapiens	0-16
11958479-3	2002	DHPG is formed when norepinephrine is incubated with aldose reductase in the presence of monoamine oxidase.	Norepinephrine	20-34	aldo-keto reductase family 1 member B	Homo sapiens	53-69
11958479-8	2002	These results suggest that aldose reductase may be important in metabolizing the potentially toxic aldehyde intermediate formed from norepinephrine in human sympathetic ganglia.	Norepinephrine	133-147	aldo-keto reductase family 1 member B	Homo sapiens	27-43
11830287-7	2002	Orexin-A (1000 nM) significantly increased the release of both epinephrine (E) and norepinephrine (NE) from porcine adrenal medullary cells.	Norepinephrine	83-97	hypocretin neuropeptide precursor	Rattus norvegicus	0-8
11900481-0	2002	Norepinephrine specifically stimulates ribonucleotide reductase subunit R2 gene expression in proliferating brown adipocytes: mediation via a cAMP/PKA pathway involving Src and Erk1/2 kinases.	Norepinephrine	0-14	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	169-172
11900481-0	2002	Norepinephrine specifically stimulates ribonucleotide reductase subunit R2 gene expression in proliferating brown adipocytes: mediation via a cAMP/PKA pathway involving Src and Erk1/2 kinases.	Norepinephrine	0-14	mitogen-activated protein kinase 3	Homo sapiens	177-183
11959387-4	2002	The purpose of this study was to examine in patients with CHF and in comparison to healthy controls subjects whether norepinephrine, TNFalpha or leptin relate to insulin sensitivity.	Norepinephrine	117-131	insulin	Homo sapiens	162-169
11943139-4	2002	Sympathetic stimulation in vivo (i.e. cold exposure or beta(3)-adrenergic agonist treatment) and in vitro (i.e. noradrenaline treatment of cultured cells) significantly increased both cytosolic and nuclear eNOS and iNOS expression and activities.	Norepinephrine	112-125	nitric oxide synthase 2	Rattus norvegicus	215-219
11922898-0	2002	Neuropeptide Y modifies the hypertrophic response of adult ventricular cardiomyocytes to norepinephrine.	Norepinephrine	89-103	neuropeptide Y	Rattus norvegicus	0-14
11855829-3	2002	In the present study on cultured rat hepatocytes we show that although the comitogenic GPCR agonists prostaglandin F(2alpha), vasopressin, angiotensin II, and norepinephrine all activated ERK, blocking of the ERK pathway with the MEK inhibitor PD 98059 did not abolish their comitogenic effects.	Norepinephrine	159-173	Eph receptor B1	Rattus norvegicus	188-191
11855829-3	2002	In the present study on cultured rat hepatocytes we show that although the comitogenic GPCR agonists prostaglandin F(2alpha), vasopressin, angiotensin II, and norepinephrine all activated ERK, blocking of the ERK pathway with the MEK inhibitor PD 98059 did not abolish their comitogenic effects.	Norepinephrine	159-173	Eph receptor B1	Rattus norvegicus	209-212
11922898-2	2002	On the other hand, neuropeptide Y (NPY), known to be co-secreted with norepinephrine from intramural nerve endings of the heart, exerts an anti-beta-adrenergic effect.	Norepinephrine	70-84	neuropeptide Y	Rattus norvegicus	19-33
11922898-2	2002	On the other hand, neuropeptide Y (NPY), known to be co-secreted with norepinephrine from intramural nerve endings of the heart, exerts an anti-beta-adrenergic effect.	Norepinephrine	70-84	neuropeptide Y	Rattus norvegicus	35-38
11922898-3	2002	Therefore, it should be expected that NPY enhances the hypertrophic response to norepinephrine.	Norepinephrine	80-94	neuropeptide Y	Rattus norvegicus	38-41
11922898-9	2002	In co-presence of NPY (100 nmol/l), however, norepinephrine increased protein synthesis by 44% and RNA synthesis by 18%.	Norepinephrine	45-59	neuropeptide Y	Rattus norvegicus	18-21
11922898-10	2002	Under the same conditions, NPY enhanced the effect of norepinephrine on cell volume from +6.4 to +18.2%, its effect on cross-sectional area from +16 to +23%, and increased the protein/DNA ratio from 32.5 to 35.6 mg/mg.	Norepinephrine	54-68	neuropeptide Y	Rattus norvegicus	27-30
11922898-11	2002	In parallel, norepinephrine caused a translocation of PKC-alpha and PKC-delta into the particular fractions and this effect of norepinephrine was also enhanced by co-presence of NPY.	Norepinephrine	13-27	neuropeptide Y	Rattus norvegicus	178-181
11869170-6	2002	Addition of the iNOS inhibitor aminoguanidine resulted in full recovery of the responses to noradrenaline in superior mesenteric, renal and hepatic arteries.	Norepinephrine	92-105	nitric oxide synthase 2	Rattus norvegicus	16-20
11922898-11	2002	In parallel, norepinephrine caused a translocation of PKC-alpha and PKC-delta into the particular fractions and this effect of norepinephrine was also enhanced by co-presence of NPY.	Norepinephrine	127-141	neuropeptide Y	Rattus norvegicus	178-181
11922898-13	2002	CONCLUSION: Our study indicates the anti-beta-adrenergic effect of NPY is sufficient to modulate the hypertrophic response of adult ventricular cardiomyocytes to norepinephrine.	Norepinephrine	162-176	neuropeptide Y	Rattus norvegicus	67-70
11922898-14	2002	The results suggest that the hypertrophic effect of norepinephrine via alpha-adrenoceptor stimulation can be modulated by co-release of NPY from intramural nerve endings.	Norepinephrine	52-66	neuropeptide Y	Rattus norvegicus	136-139
11931349-4	2002	Combination of PACAP38, PACAP27 (each at 0.1 microM) and VIP (1 microM) with adrenaline or noradrenaline resulted in most cases in additive effects, with some supraadditive (PACAP27 plus adrenaline) or subadditive (PACAP38 or VIP plus noradrenaline) fluctuations.	Norepinephrine	91-104	vasoactive intestinal peptide	Rattus norvegicus	226-229
22033776-2	2002	Substance P is widely distributed throughout the central nervous system, where if is often colocalized with serotonin, norepinephrine, and dopamine.	Norepinephrine	119-133	tachykinin precursor 1	Homo sapiens	0-11
11918665-10	2002	mTNF-alpha increased norepinephrine (NE), 5-HT and dopamine (DA) activity within the PVN and median eminence/arcuate nucleus complex (ME/ARC), and NE utilization within the central amygdala.	Norepinephrine	21-35	tumor necrosis factor	Mus musculus	0-10
11875370-6	2002	Compared with the wild-type hNET, the maximum rate (V(max)) of norepinephrine uptake by the Ala(457)Pro variant was slightly reduced, whereas the turnover number (calculated from V(max)/B(max)) was approximately two-fold higher.	Norepinephrine	63-77	solute carrier family 6 member 2	Homo sapiens	28-32
11875370-7	2002	However, the Ala(457)Pro variant exhibited a 50-fold higher K(m) (i.e. lower apparent affinity) for norepinephrine than the wild-type hNET.	Norepinephrine	100-114	solute carrier family 6 member 2	Homo sapiens	134-138
11836295-2	2002	To address this question, we investigated the counterregulatory response to acute insulin-induced hypoglycemia of glucagon, epinephrine, and norepinephrine in eight patients who had undergone transcranial surgery for a craniopharyngioma extending to the hypothalamic region.	Norepinephrine	141-155	insulin	Homo sapiens	82-89
11931346-2	2002	A role for galanin in mediating anxiety-related behavior is suggested by the pattern of distribution in the CNS and the coexistence of galanin with norepinephrine in the locus coeruleus.	Norepinephrine	148-162	galanin and GMAP prepropeptide	Mus musculus	11-18
11880162-0	2002	Human lymphocyte growth hormone stimulates interferon gamma production and is inhibited by cortisol and norepinephrine.	Norepinephrine	104-118	growth hormone 1	Homo sapiens	17-31
11826168-3	2002	In the proximal parts of the long neuromuscular synapse, stimulation-evoked EPCs with long release latencies were eliminated when the intracellular cAMP was increased by beta1 activation by noradrenaline, by the permeable analogue db-cAMP, by activation of adenylyl cyclase or by inhibition of cAMP hydrolysis.	Norepinephrine	190-203	cathelicidin antimicrobial peptide	Homo sapiens	148-152
11826168-3	2002	In the proximal parts of the long neuromuscular synapse, stimulation-evoked EPCs with long release latencies were eliminated when the intracellular cAMP was increased by beta1 activation by noradrenaline, by the permeable analogue db-cAMP, by activation of adenylyl cyclase or by inhibition of cAMP hydrolysis.	Norepinephrine	190-203	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	170-175
11931349-4	2002	Combination of PACAP38, PACAP27 (each at 0.1 microM) and VIP (1 microM) with adrenaline or noradrenaline resulted in most cases in additive effects, with some supraadditive (PACAP27 plus adrenaline) or subadditive (PACAP38 or VIP plus noradrenaline) fluctuations.	Norepinephrine	235-248	vasoactive intestinal peptide	Rattus norvegicus	57-60
11938651-4	2002	The CRH administration led to increased dopamine and noradrenaline levels in hypothalamus and decreased those in striatum in rats of both strains, but in KLA the decrease was more evident.	Norepinephrine	53-66	corticotropin releasing hormone	Rattus norvegicus	4-7
11819028-9	2002	It is concluded that the renal sympathetic nerves in the pig possess NPY Y(2) receptors, which upon activation inhibit transmitter (noradrenaline and NPY) release.	Norepinephrine	132-145	neuropeptide Y	Sus scrofa	69-72
11914123-0	2002	Ca2+-mediated activation of ERK in hepatocytes by norepinephrine and prostaglandin F2 alpha: role of calmodulin and Src kinases.	Norepinephrine	50-64	mitogen-activated protein kinase 1	Homo sapiens	28-31
11804991-1	2002	BACKGROUND: Observations in patients with functional mutations of the norepinephrine transporter (NET) gene suggest that impaired norepinephrine uptake may contribute to idiopathic orthostatic intolerance.	Norepinephrine	70-84	solute carrier family 6 member 2	Homo sapiens	98-101
11914123-3	2002	In the present study we have explored the role of Ca2+ and Ca2+-dependent steps leading to ERK1/2 activation induced by norepinephrine and prostaglandin (PG)F2alpha.	Norepinephrine	120-134	mitogen-activated protein kinase 3	Homo sapiens	91-97
11914123-7	2002	The Src kinase inhibitors PP1 and PP2 partially diminished the ERK responses elicited by both norepinephrine and PGF2alpha.	Norepinephrine	94-108	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	4-7
11914123-7	2002	The Src kinase inhibitors PP1 and PP2 partially diminished the ERK responses elicited by both norepinephrine and PGF2alpha.	Norepinephrine	94-108	inorganic pyrophosphatase 1	Homo sapiens	26-29
11914123-7	2002	The Src kinase inhibitors PP1 and PP2 partially diminished the ERK responses elicited by both norepinephrine and PGF2alpha.	Norepinephrine	94-108	mitogen-activated protein kinase 1	Homo sapiens	63-66
12061021-2	2002	AIM: This study was aimed to evaluate the effect of drugs inhibiting both cyclooxygenase (COX) isoforms COX-1 and COX-2 on vasoconstrictor responses to noradrenaline in the rabbit renal artery and to compare these responses with femoral artery as a systemic vessel.	Norepinephrine	152-165	cytochrome c oxidase subunit I	Oryctolagus cuniculus	104-109
11818034-2	2002	We hypothesized that with ID 1) intravenous norepinephrine would alter heart rate (HR) and contractility, 2) abdominal aorta would be larger and more distensible, and 3) the beta-blocker propanolol would reduce hypertrophy.	Norepinephrine	44-58	inhibitor of DNA binding 1, HLH protein	Rattus norvegicus	26-30
11844932-0	2002	Noradrenaline-induced paxillin phosphorylation, ERK activation and MEK-regulated contraction in intact rat mesenteric arteries.	Norepinephrine	0-13	Eph receptor B1	Rattus norvegicus	48-51
11952086-5	2002	However, the response of the individual pinealocyte neuron to the norepinephrine signal depends on whether the GCAP1-linked (results in hyperpolarization) or S100beta-linked (results in depolarization) pathway is operational in the pinealocyte.	Norepinephrine	66-80	guanylate cyclase activator 1A	Homo sapiens	111-116
11952086-5	2002	However, the response of the individual pinealocyte neuron to the norepinephrine signal depends on whether the GCAP1-linked (results in hyperpolarization) or S100beta-linked (results in depolarization) pathway is operational in the pinealocyte.	Norepinephrine	66-80	S100 calcium binding protein B	Homo sapiens	158-166
12127086-9	2002	In addition, neurochemical analysis of monoamine neurotransmitters revealed a considerable increase in brain norepinephrine turnover in mice lacking alpha(2A)-AR.	Norepinephrine	109-123	adrenergic receptor, alpha 2a	Mus musculus	149-157
11927164-8	2002	In alpha(2A)-receptor-deficient mice, the inhibitory effect of the alpha(2)-receptor agonist on norepinephrine and dopamine release was significantly reduced but not abolished.	Norepinephrine	96-110	adrenergic receptor, alpha 2a	Mus musculus	3-11
11927164-10	2002	The time course of onset of presynaptic inhibition of norepinephrine release was much faster for the alpha(2A)-receptor than for the alpha(2C)-subtype.	Norepinephrine	54-68	adrenergic receptor, alpha 2a	Mus musculus	101-109
12196911-1	2002	The norepinephrine, dopamine and serotonin transporters (NET, DAT and SERT, respectively), limit cellular signaling by recapturing released neurotransmitter, and serve as targets for antidepressants and drugs of abuse, emphasizing the integral role these molecules play in neurotransmission and pathology.	Norepinephrine	4-18	solute carrier family 6 member 4	Homo sapiens	70-74
11739311-4	2001	METHODS AND RESULTS: In primary cardiac myocytes from neonatal rats, immunohistochemical analyses using a specific monoclonal antibody against LOX-1 demonstrated that LOX-1 expression was markedly induced by stimulation with norepinephrine and endothelin-1.	Norepinephrine	225-239	endothelin 1	Rattus norvegicus	244-256
11591725-8	2001	This observation correlated with a higher affinity of norepinephrine at the murine alpha(2C)- than at the alpha(2A)-receptor subtype and may explain why alpha(2C)-adrenergic receptors are especially suited to control sympathetic neurotransmission at low action potential frequencies in contrast to the alpha(2A)-receptor subtype.	Norepinephrine	54-68	adrenergic receptor, alpha 2a	Mus musculus	106-114
11591725-8	2001	This observation correlated with a higher affinity of norepinephrine at the murine alpha(2C)- than at the alpha(2A)-receptor subtype and may explain why alpha(2C)-adrenergic receptors are especially suited to control sympathetic neurotransmission at low action potential frequencies in contrast to the alpha(2A)-receptor subtype.	Norepinephrine	54-68	adrenergic receptor, alpha 2a	Mus musculus	302-310
11750790-1	2001	The availability of mutant mice that lack either MAO A or MAO B has created unique profiles in the central and peripheral availability of serotonin, norepinephrine, dopamine, and phenylethylamine.	Norepinephrine	149-163	monoamine oxidase B	Mus musculus	58-63
11551920-0	2001	Smad7 is induced by norepinephrine and protects rat hepatocytes from activin A-induced growth inhibition.	Norepinephrine	20-34	SMAD family member 7	Rattus norvegicus	0-5
11705774-0	2001	Comparative actions of adrenomedullin and nitroprusside: interactions with ANG II and norepinephrine.	Norepinephrine	86-100	pro-adrenomedullin	Ovis aries	23-37
11742865-2	2001	To investigate the signaling pathways involved in contraction, we studied the activation and regulation of p38 mitogen-activated protein kinases (p38MAPKs) and heat shock protein (HSP) kinase by endothelin and noradrenaline in rat mesenteric arteries.	Norepinephrine	210-223	selenoprotein K	Rattus norvegicus	160-178
11742865-2	2001	To investigate the signaling pathways involved in contraction, we studied the activation and regulation of p38 mitogen-activated protein kinases (p38MAPKs) and heat shock protein (HSP) kinase by endothelin and noradrenaline in rat mesenteric arteries.	Norepinephrine	210-223	selenoprotein K	Rattus norvegicus	180-183
11724752-0	2001	Orexin A and B evoke noradrenaline release from rat cerebrocortical slices.	Norepinephrine	21-34	hypocretin neuropeptide precursor	Rattus norvegicus	0-8
11724752-17	2001	We conclude that the neuropeptides orexin A and B evoke noradrenaline release from rat cerebrocortical slices.	Norepinephrine	56-69	hypocretin neuropeptide precursor	Rattus norvegicus	35-43
11733701-0	2001	Vasopressin differentially modulates noradrenaline release in the rat supraoptic nucleus.	Norepinephrine	37-50	arginine vasopressin	Rattus norvegicus	0-11
11733701-2	2001	In order to investigate presynaptic roles of dendritically released vasopressin, we examined effects of local application of vasopressin upon noradrenaline release within the supraoptic nucleus by a microdialysis method.	Norepinephrine	142-155	arginine vasopressin	Rattus norvegicus	125-136
11734616-0	2001	Norepinephrine and beta 2-adrenergic receptor stimulation regulate CD4+ T and B lymphocyte function in vitro and in vivo.	Norepinephrine	0-14	CD4 molecule	Homo sapiens	67-70
11684043-6	2001	Noradrenaline stimulated melatonin release was attenuated by AVP.	Norepinephrine	0-13	arginine vasopressin	Rattus norvegicus	61-64
11733701-4	2001	Vasopressin augmented noradrenaline increase after high K+ but reduced it after an NMDA receptor antagonist, AP-5.	Norepinephrine	22-35	arginine vasopressin	Rattus norvegicus	0-11
11733701-5	2001	The results suggest that dendritically released vasopressin modulates noradrenaline release within the supraoptic nucleus in a bimodal fashion.	Norepinephrine	70-83	arginine vasopressin	Rattus norvegicus	48-59
11641355-12	2001	A significant correlation (P = 0.004) between resting IL-6 and urinary norepinephrine excretion rates was found over the course of time while at altitude.	Norepinephrine	71-85	interleukin 6	Homo sapiens	54-58
11602816-7	2001	Attenuation of norepinephrine release during exercise by valsartan suggests that angiotensin II facilitates the release of norepinephrine from sympathetic postganglionic neurons.	Norepinephrine	15-29	angiotensinogen	Homo sapiens	81-95
11602816-7	2001	Attenuation of norepinephrine release during exercise by valsartan suggests that angiotensin II facilitates the release of norepinephrine from sympathetic postganglionic neurons.	Norepinephrine	123-137	angiotensinogen	Homo sapiens	81-95
11602816-8	2001	Angiotensin II, therefore, contributes to the pressor response to exercise by inducing peripheral vasoconstriction and facilitation of norepinephrine release from postganglionic sympathetic nerve endings that are unrelated to central activation of the autonomic nervous system.	Norepinephrine	135-149	angiotensinogen	Homo sapiens	0-14
11602680-0	2001	Trafficking-dependent and -independent pathways of neurotransmitter transporter regulation differentially involving p38 mitogen-activated protein kinase revealed in studies of insulin modulation of norepinephrine transport in SK-N-SH cells.	Norepinephrine	198-212	mitogen-activated protein kinase 14	Homo sapiens	116-152
11602680-0	2001	Trafficking-dependent and -independent pathways of neurotransmitter transporter regulation differentially involving p38 mitogen-activated protein kinase revealed in studies of insulin modulation of norepinephrine transport in SK-N-SH cells.	Norepinephrine	198-212	insulin	Homo sapiens	176-183
11606427-2	2001	To link Ang II to the regulation of norepinephrine metabolism in neurons cultured from newborn rat hypothalamus and brainstem we have used cDNA arrays for high throughput gene expression profiling.	Norepinephrine	36-50	angiotensinogen	Rattus norvegicus	8-14
11606427-3	2001	Of several genes that were regulated, we focused on macrophage migration inhibitory factor (MIF), which has been associated with the modulation of norepinephrine metabolism.	Norepinephrine	147-161	macrophage migration inhibitory factor	Rattus norvegicus	92-95
11606427-7	2001	Taken together with our observation that MIF is expressed in the terminal fields of noradrenergic neurons (hypothalamus) and that Ang II increases the expression of MIF in this region in vivo, our data may suggest a novel role of Ang II in norepinephrine metabolism.	Norepinephrine	240-254	macrophage migration inhibitory factor	Rattus norvegicus	41-44
11606427-7	2001	Taken together with our observation that MIF is expressed in the terminal fields of noradrenergic neurons (hypothalamus) and that Ang II increases the expression of MIF in this region in vivo, our data may suggest a novel role of Ang II in norepinephrine metabolism.	Norepinephrine	240-254	angiotensinogen	Rattus norvegicus	130-136
11606427-7	2001	Taken together with our observation that MIF is expressed in the terminal fields of noradrenergic neurons (hypothalamus) and that Ang II increases the expression of MIF in this region in vivo, our data may suggest a novel role of Ang II in norepinephrine metabolism.	Norepinephrine	240-254	macrophage migration inhibitory factor	Rattus norvegicus	165-168
11606427-7	2001	Taken together with our observation that MIF is expressed in the terminal fields of noradrenergic neurons (hypothalamus) and that Ang II increases the expression of MIF in this region in vivo, our data may suggest a novel role of Ang II in norepinephrine metabolism.	Norepinephrine	240-254	angiotensinogen	Rattus norvegicus	230-236
11697740-0	2001	Bradykinin facilitates noradrenaline spillover during contraction in the canine gracilis muscle.	Norepinephrine	23-36	kininogen 1	Canis lupus familiaris	0-10
11605943-7	2001	The isoflurane-induced enhancement of norepinephrine response was still observed after inhibitions of the nitric oxide, endothelium-derived hyperpolarizing factor, cyclooxygenase and lipoxygenase pathways, or after blockade of endothelin-1, angiotensin-II, and serotonin receptors; however, it was prevented by superoxide dismutase.	Norepinephrine	38-52	endothelin 1	Rattus norvegicus	227-239
11605943-7	2001	The isoflurane-induced enhancement of norepinephrine response was still observed after inhibitions of the nitric oxide, endothelium-derived hyperpolarizing factor, cyclooxygenase and lipoxygenase pathways, or after blockade of endothelin-1, angiotensin-II, and serotonin receptors; however, it was prevented by superoxide dismutase.	Norepinephrine	38-52	angiotensinogen	Rattus norvegicus	241-255
11702842-4	2001	Insulin-mediated attenuation of the vasoconstriction response to noradrenaline, before and after nitric oxide synthase inhibition, was studied in isolated arteries using wire myography.	Norepinephrine	65-78	insulin	Homo sapiens	0-7
11702842-5	2001	Vessel responses to noradrenaline following incubation with insulin were also tested after endothelial denudation.	Norepinephrine	20-33	insulin	Homo sapiens	60-67
11702842-9	2001	Following inhibition of nitric oxide synthase with L-NAME, addition of the insulin was still able to produce a significant attenuation in maximum vasoconstriction to noradrenaline in pregnant women (P < 0.01).	Norepinephrine	166-179	insulin	Homo sapiens	75-82
11697740-4	2001	Because the B2 bradykinin receptor facilitates noradrenaline spillover, it may be involved in the increase associated with contraction.	Norepinephrine	47-60	bradykinin receptor B2	Canis lupus familiaris	12-34
11697740-5	2001	In this experiment, we studied the effect of bradykinin on noradrenaline spillover in the in situ canine gracilis muscle, using the specific B2 antagonist HOE 140.	Norepinephrine	59-72	kininogen 1	Canis lupus familiaris	45-55
11697740-9	2001	In light of our results, it seems that bradykinin formation during muscle contraction may play an important part in the observed increase in noradrenaline spillover but does not affect fractional extraction.	Norepinephrine	141-154	kininogen 1	Canis lupus familiaris	39-49
11573972-4	2001	The A1 pathway transmits hemodynamic information to the vasopressin neurons by releasing several neuroactive agents including ATP, norepinephrine, neuropeptide Y, and substance P.	Norepinephrine	131-145	arginine vasopressin	Homo sapiens	56-67
11673761-1	2001	OBJECTIVE: To elucidate the effects and molecular mechanism(s) by means of which noradrenaline (NA) protects against the tumor necrosis factor (TNF)-alpha-induced apoptosis of brown adipocytes.	Norepinephrine	81-94	tumor necrosis factor	Rattus norvegicus	121-154
11600565-8	2001	We suggest that a cortisol-, norepinephrine-, and 1,25-dihydroxyvitamin-induced inhibition and subsequent rebound of IL-12 and TNF-alpha production may represent a major mechanism by which pregnancy and postpartum alter the course of or susceptibility to various autoimmune disorders.	Norepinephrine	29-43	tumor necrosis factor	Homo sapiens	127-136
11642733-0	2001	TGF-beta1 and IL-6 expression in rat pineal gland is regulated by norepinephrine and interleukin-1beta.	Norepinephrine	66-80	transforming growth factor, beta 1	Rattus norvegicus	0-9
11642733-0	2001	TGF-beta1 and IL-6 expression in rat pineal gland is regulated by norepinephrine and interleukin-1beta.	Norepinephrine	66-80	interleukin 6	Rattus norvegicus	14-18
11642733-7	2001	The sympathetic neurotransmitter norepinephrine (NE) increased transcript levels for both TGF-beta1 and IL-6 in adult pineal organ cultures.	Norepinephrine	33-47	transforming growth factor, beta 1	Rattus norvegicus	90-99
11642733-7	2001	The sympathetic neurotransmitter norepinephrine (NE) increased transcript levels for both TGF-beta1 and IL-6 in adult pineal organ cultures.	Norepinephrine	33-47	interleukin 6	Rattus norvegicus	104-108
12123471-1	2001	1 The effects of stress in rats were evaluated by measuring changes in body weight and in responsiveness to noradrenaline (NA) in the isolated vas deferens and atria after the animals had been exposed to restraint or restraint and isolation.	Norepinephrine	108-121	arginine vasopressin	Rattus norvegicus	143-146
11572794-0	2001	Angiotensin II enhances noradrenaline release from sympathetic nerves of the rat prostate via a novel angiotensin receptor: implications for the pathophysiology of benign prostatic hyperplasia.	Norepinephrine	24-37	angiotensinogen	Rattus norvegicus	0-14
11593103-0	2001	Angiotensin converting enzyme inhibition improves cardiac neuronal uptake of noradrenaline in spontaneously hypertensive rats.	Norepinephrine	77-90	angiotensin I converting enzyme	Rattus norvegicus	0-29
11435416-2	2001	Whereas norepinephrine (NE) is a potent inducer of ET-1 expression in cardiac myocytes, the signaling pathways that link NE to inducible cardiac ET-1 expression are unknown.	Norepinephrine	8-22	endothelin 1	Rattus norvegicus	51-55
11838318-1	2001	Endotoxin (lipopolysaccharide, LPS) is known to activate the hypothalamo-pituitary adrenocortical axis, as well as norepinephrine and indolamine metabolism.	Norepinephrine	115-129	toll-like receptor 4	Mus musculus	31-34
11494078-10	2001	These results support our hypothesis that NO acts to directly stimulate relaxation of cavernous smooth muscle and to inhibit the vasoconstrictor actions of agents like ET-1 and alpha-adrenergic agonists including norepinephrine.	Norepinephrine	213-227	endothelin 1	Rattus norvegicus	168-182
11594790-3	2001	Our results indicate that thymic stimulation (performed by means of interleukin 1beta) induces substantial changes in the fresh weight of the whole thymus, as well as in the thymic microenvironment, thymic nerve fibres, CNF, neuropeptide Y (NPY)-like positive nerve fibres and total amount of both proteins and norepinephrine in rat thymic tissue homogenates.	Norepinephrine	311-325	interleukin 1 beta	Rattus norvegicus	68-85
11517018-1	2001	OBJECTIVE: Stress-induced release of noradrenaline (NA) from locus coeruleus (LC) neurons is mainly regulated by corticotropin-releasing hormone (CRH).	Norepinephrine	37-50	corticotropin releasing hormone	Rattus norvegicus	113-144
11517018-1	2001	OBJECTIVE: Stress-induced release of noradrenaline (NA) from locus coeruleus (LC) neurons is mainly regulated by corticotropin-releasing hormone (CRH).	Norepinephrine	37-50	corticotropin releasing hormone	Rattus norvegicus	146-149
11677796-2	2001	The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3).	Norepinephrine	45-58	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	180-188
11677796-2	2001	The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3).	Norepinephrine	45-58	adrenergic receptor, alpha 2a	Mus musculus	236-244
11677796-8	2001	The release of noradrenaline from sympathetic nerves is controlled by presynaptic alpha 2A- and alpha 2C-receptors.	Norepinephrine	15-28	adrenergic receptor, alpha 2a	Mus musculus	82-90
11418608-4	2001	VPA also increased the expression of genes regulated by the ERK pathway, including growth cone-associated protein 43 and Bcl-2, promoted neurite growth and cell survival, and enhanced norepinephrine uptake and release.	Norepinephrine	184-198	mitogen-activated protein kinase 1	Homo sapiens	60-63
11580884-3	2001	These include central sites (eg, rostral ventrolateral medulla), at the level of baroreflex control, and at the sympathetic prejunctional angiotensin II receptor 1 (AT(1)) receptor, which is facilitatory for norepinephrine release from the sympathetic nerve terminal.	Norepinephrine	208-222	angiotensinogen	Rattus norvegicus	138-152
11504796-1	2001	We compared the effects of dopamine and norepinephrine on vasopressin (AVP)-stimulated increases in osmotic water permeability (Pf) and cAMP accumulation in the rat inner medullary collecting duct (IMCD).	Norepinephrine	40-54	arginine vasopressin	Rattus norvegicus	58-69
11448843-5	2001	Arterial pressure increases, in response to norepinephrine injection, were greater in the NPY-tg rats.	Norepinephrine	44-58	neuropeptide Y	Rattus norvegicus	90-93
11448843-7	2001	These results indicate that NPY, when expressed in increased amounts, potentiates the pressor effects of norepinephrine and contributes to maintaining blood pressure during hemorrhage, but it does not alter resting blood pressure.	Norepinephrine	105-119	neuropeptide Y	Rattus norvegicus	28-31
11448843-8	2001	These transgenic rats will facilitate studies of the role of NPY signaling in cardiovascular regulation, particularly regarding its functional cooperation with norepinephrine.	Norepinephrine	160-174	neuropeptide Y	Rattus norvegicus	61-64
11534851-16	2001	The main presynaptic alpha2-autoreceptors are alpha2A/D, both as sites of action of exogenous agonists and as sites of action of previously released noradrenaline.	Norepinephrine	149-162	adrenergic receptor, alpha 2a	Mus musculus	46-55
11952872-2	2001	This study investigates the effect of acute in vivo and in vitro ethanol administration on the contractions evoked electrically and by exogenous noradrenaline and alpha,beta-methylene-ATP in the rat bisected vas deferens.	Norepinephrine	145-158	arginine vasopressin	Rattus norvegicus	208-211
11952872-10	2001	selectively impaired the response to noradrenaline only in the prostatic portion of rat vas deferens while it was devoid of any action on alpha,beta-methylene-ATP contractions.	Norepinephrine	37-50	arginine vasopressin	Rattus norvegicus	88-91
11406463-6	2001	However, a 50-fold increase of IL--6 mRNA was found after stimulation with norepinephrine (NE).	Norepinephrine	75-89	interleukin 6	Rattus norvegicus	31-36
11333263-1	2001	The norepinephrine transporter (NET) is responsible for the rapid NaCl-dependent uptake of norepinephrine into presynaptic noradrenergic nerve endings.	Norepinephrine	4-18	solute carrier family 6 member 2	Homo sapiens	32-35
11476962-0	2001	The role of Kupffer cell alpha(2)-adrenoceptors in norepinephrine-induced TNF-alpha production.	Norepinephrine	51-65	tumor necrosis factor	Rattus norvegicus	74-83
11422221-0	2001	Mechanisms of endothelin-1-induced potentiation of noradrenaline response in rat mesenteric artery.	Norepinephrine	51-64	endothelin 1	Rattus norvegicus	14-26
11429329-7	2001	Norepinephrine requirements could be reduced by 72% within 72 h. During AVP infusion, a significant increase in liver enzymes and total bilirubin concentration and a significant decrease in platelet count occurred.	Norepinephrine	0-14	arginine vasopressin	Homo sapiens	72-75
11422221-2	2001	Subthreshold concentrations of endothelin (ET)-1 enhance the contractile responses to noradrenaline (NA).	Norepinephrine	86-99	endothelin 1	Rattus norvegicus	31-48
11373471-7	2001	MEASUREMENTS AND MAIN RESULTS: Epinephrine and norepinephrine increased the production of IL-6 but not of IL-1alpha in normal abdominal skin, and these increases were reversed by a beta-blocker (propranolol hydrochloride) but not an alpha-blocker (phentolamine mesylate).	Norepinephrine	47-61	interleukin 6	Mus musculus	90-94
11425914-2	2001	The alpha(2)-adrenergic receptors (alpha(2)-ARs) modulate norepinephrine release, as well as the release of serotonin and other neurotransmitters, and are therefore potential targets for antidepressant and anxiolytic drug development.	Norepinephrine	58-72	adrenergic receptor, alpha 2a	Mus musculus	35-47
11525314-5	2001	Prazosin, cyclazosin, RS-100329 and Ro70-0004/003 antagonized norepinephrine-induced contractile responses with affinity estimates (pK(B) or pA2) of 8.4, 7.3, 9.2 and 8.8, respectively, consistent with the singular involvement of alpha1A-adrenoceptor subtype.	Norepinephrine	62-76	AKT serine/threonine kinase 1	Homo sapiens	132-137
11371937-2	2001	MATERIALS AND METHODS: The contractile responses of 17 circular smooth muscle strips of human vas deferens to 10-4 M. norepinephrine were observed in the absence and presence of clomipramine, and the selective serotonin re-uptake inhibitors fluoxetine, sertraline and paroxetine.	Norepinephrine	118-132	arginine vasopressin	Rattus norvegicus	94-97
11316770-2	2001	Stress activates A1/A2 noradrenergic neurons, and then noradrenaline (NA) stimulates ACTH secretion through hypothalamic CRH.	Norepinephrine	55-68	proopiomelanocortin	Homo sapiens	85-89
11334870-2	2001	The renal vasoconstrictor response to neuropeptide Y in anaesthetized rats was dose-dependently antagonized by H 394/84 (ID(50) value=41+/-4 nmol/kg/min), whereas the renal vascular responses to noradrenaline and angiotensin II were only slightly affected by H 394/84 (500 nmol/kg/min).	Norepinephrine	195-208	neuropeptide Y	Rattus norvegicus	38-52
11339685-2	2001	ANGII increased MABP as well as the contractile response to noradrenaline in vessels from ANGII-treated animals.	Norepinephrine	60-73	angiotensinogen	Rattus norvegicus	0-5
11339685-2	2001	ANGII increased MABP as well as the contractile response to noradrenaline in vessels from ANGII-treated animals.	Norepinephrine	60-73	angiotensinogen	Rattus norvegicus	90-95
11432980-1	2001	The expression of inducible nitric oxide synthase (NOS2) in glial cells is inhibited by neurotransmitters such as norepinephrine (NE) which elevate cAMP levels.	Norepinephrine	114-128	nitric oxide synthase 2	Rattus norvegicus	18-49
11432980-1	2001	The expression of inducible nitric oxide synthase (NOS2) in glial cells is inhibited by neurotransmitters such as norepinephrine (NE) which elevate cAMP levels.	Norepinephrine	114-128	nitric oxide synthase 2	Rattus norvegicus	51-55
11344198-1	2001	This study examined the mechanisms linking different biochemical and clinical phenotypes of pheochromocytoma in multiple endocrine neoplasia type 2 (MEN 2) and von Hippel-Lindau (VHL) syndrome to underlying differences in the expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, and of phenylethanolamine N-methyltransferase (PNMT), the enzyme that converts norepinephrine to epinephrine.	Norepinephrine	399-413	tyrosine hydroxylase	Homo sapiens	240-260
11303058-1	2001	The pleiotropic cytokine tumor necrosis factor-alpha (TNF) and alpha(2)-adrenergic receptor activation regulate norepinephrine (NE) release from neurons in the central nervous system.	Norepinephrine	112-126	tumor necrosis factor	Rattus norvegicus	25-52
11303058-1	2001	The pleiotropic cytokine tumor necrosis factor-alpha (TNF) and alpha(2)-adrenergic receptor activation regulate norepinephrine (NE) release from neurons in the central nervous system.	Norepinephrine	112-126	tumor necrosis factor	Rattus norvegicus	54-57
11403997-2	2001	In the present study we compared the effect of angiotensin II and angiotensin 1-7 on the concentration of dopamine, serotonin, epinephrine, and norepinephrine and some of their metabolites in the rat hypothalamus, where the levels of angiotensins are particularly high.	Norepinephrine	144-158	angiotensinogen	Rattus norvegicus	47-81
11403997-3	2001	Intracerebroventricular injection of angiotensin II, but not angiotensin 1-7, time-dependently elevated the levels of both epinephrine (p < 0.05) and norepinephrine (p < 0.05) in the hypothalamus and both effects could be prevented by intracerebroventricular injection of either AT(1) (candesartan), AT(2) (PD123319) or AT(1-7) (A-779) receptor antagonist.	Norepinephrine	153-167	angiotensinogen	Rattus norvegicus	37-51
11300659-8	2001	These findings suggest that bradykinin suppresses the RNS-induced norepinephrine overflow and renal actions via nitric oxide production mediated by activation of B2 receptor.	Norepinephrine	66-80	kininogen 1	Canis lupus familiaris	28-38
11306173-5	2001	When HB2 cells were stimulated by norepinephrine, the VEGF mRNA level increased without a change in that of VEGF-B, while the VEGF-C mRNA level decreased.	Norepinephrine	34-48	vascular endothelial growth factor C	Mus musculus	126-132
11266507-3	2001	Here, we show that epinephrine and norepinephrine potentiate ligand-dependent GR transactivation in a hippocampal cell line (HT22) via beta(2)-adrenergic receptors.	Norepinephrine	35-49	nuclear receptor subfamily 3 group C member 1	Homo sapiens	78-80
11295232-0	2001	Norepinephrine-induced CRH and AVP gene transcription within the hypothalamus: differential regulation by corticosterone.	Norepinephrine	0-14	corticotropin releasing hormone	Rattus norvegicus	23-26
11295232-0	2001	Norepinephrine-induced CRH and AVP gene transcription within the hypothalamus: differential regulation by corticosterone.	Norepinephrine	0-14	arginine vasopressin	Rattus norvegicus	31-34
11295232-1	2001	We have previously demonstrated that microinjection of norepinephrine (NE) into the paraventricular nucleus of the hypothalamus (PVN) of conscious rats elicits a marked increase in CRH gene transcription, indicated by CRH hnRNA levels, without changing AVP hnRNA levels.	Norepinephrine	55-69	corticotropin releasing hormone	Rattus norvegicus	181-184
11295232-1	2001	We have previously demonstrated that microinjection of norepinephrine (NE) into the paraventricular nucleus of the hypothalamus (PVN) of conscious rats elicits a marked increase in CRH gene transcription, indicated by CRH hnRNA levels, without changing AVP hnRNA levels.	Norepinephrine	55-69	corticotropin releasing hormone	Rattus norvegicus	218-221
11295232-1	2001	We have previously demonstrated that microinjection of norepinephrine (NE) into the paraventricular nucleus of the hypothalamus (PVN) of conscious rats elicits a marked increase in CRH gene transcription, indicated by CRH hnRNA levels, without changing AVP hnRNA levels.	Norepinephrine	55-69	arginine vasopressin	Rattus norvegicus	253-256
11181554-5	2001	In rat prostate, Ang II (0.01-1 microM) produced a concentration-dependent increase in [(3)H]-noradrenaline release from sympathetic nerves.	Norepinephrine	94-107	angiotensinogen	Rattus norvegicus	17-23
11245639-4	2001	Subcutaneous resistance arteries constricted in response to norepinephrine (maximum tension, 2.84+/-0.38 mN/mm; the concentration required to produce 50% of the maximum response [EC(50)], 0.52+/-0.07 micromol/L) and endothelin-1 (maximum tension, 4.19+/-0.93 mN/mm; EC(50), 1.6+/-0.1 nmol/L).	Norepinephrine	60-74	endothelin 1	Rattus norvegicus	216-228
11245851-3	2001	Norepinephrine-induced vasoconstriction was significantly enhanced by subpressor dose of endothelin-1 (0.3 nM), both in SHRSPs and WKYs.	Norepinephrine	0-14	endothelin 1	Rattus norvegicus	89-101
11245851-4	2001	In SHRSPs, endothelin-1-induced enhancement was abolished by FR139317, in contrast to the case with WKYs, in which BQ788 markedly suppressed endothelin-1-induced augmentation of norepinephrine responses.	Norepinephrine	178-192	endothelin 1	Rattus norvegicus	11-23
11245851-4	2001	In SHRSPs, endothelin-1-induced enhancement was abolished by FR139317, in contrast to the case with WKYs, in which BQ788 markedly suppressed endothelin-1-induced augmentation of norepinephrine responses.	Norepinephrine	178-192	endothelin 1	Rattus norvegicus	141-153
11245851-5	2001	Our results indicate that exogenous endothelin-1 enhances contractile responses to norepinephrine in mesenteric arteries of WKYs and SHRSPs, through activation of different receptor subtypes.	Norepinephrine	83-97	endothelin 1	Rattus norvegicus	36-48
11229419-0	2001	Urinary epinephrine and norepinephrine interrelations with obesity, insulin, and the metabolic syndrome in Hong Kong Chinese.	Norepinephrine	24-38	insulin	Homo sapiens	68-75
11766830-7	2001	Severity of heart failure as determined by cardiac index, LV end-diastolic diameter, and plasma noradrenaline concentrations correlated markedly with baseline serum insulin-like growth factor-1 (IGF-1) levels.	Norepinephrine	96-109	insulin like growth factor 1	Homo sapiens	165-193
11766830-7	2001	Severity of heart failure as determined by cardiac index, LV end-diastolic diameter, and plasma noradrenaline concentrations correlated markedly with baseline serum insulin-like growth factor-1 (IGF-1) levels.	Norepinephrine	96-109	insulin like growth factor 1	Homo sapiens	195-200
11239021-1	2001	BACKGROUND: It has been reported that human recombinant erythropoietin (rHuEpo) modulates the sensitivity of the cardiovascular system to angiotensin II (Ang II) or noradrenaline (NA).	Norepinephrine	165-178	erythropoietin	Homo sapiens	56-70
11239906-2	2001	Furthermore, the increase in norepinephrine release in response to the stress-related peptide corticotropin-releasing hormone (CRH) is potentiated by prior chronic stress exposure.	Norepinephrine	29-43	corticotropin releasing hormone	Rattus norvegicus	94-125
11239906-2	2001	Furthermore, the increase in norepinephrine release in response to the stress-related peptide corticotropin-releasing hormone (CRH) is potentiated by prior chronic stress exposure.	Norepinephrine	29-43	corticotropin releasing hormone	Rattus norvegicus	127-130
11230293-4	2001	To investigate this, we studied the effects of subthreshold concentrations of insulin (100 mU/L) on norepinephrine-induced contraction in rat aortas following short-term and long-term endothelin blockade.	Norepinephrine	100-114	insulin	Homo sapiens	78-85
11227667-13	2001	In vitro, the amount of hepatocellular apoptosis induced by transforming growth factor-beta1 was significantly decreased by incubation with norepinephrine.	Norepinephrine	140-154	transforming growth factor, beta 1	Rattus norvegicus	60-92
11238717-2	2001	We recently reported that central administration of lipopolysaccharide induces peripheral interleukin-6 responses via both the central and peripheral norepinephrine system.	Norepinephrine	150-164	interleukin 6	Mus musculus	90-103
11238717-11	2001	Either central or peripheral norepinephrine depletion effectively inhibited the Abeta(1-42)-induced peripheral interleukin-6 response.	Norepinephrine	29-43	interleukin 6	Mus musculus	111-124
11238717-13	2001	These results demonstrate that centrally administered Abeta(1-42) effectively induces the systemic interleukin-6 response which is mediated, in part, by central Abeta(1-42)-induced activation of the central and the peripheral norepinephrine systems.	Norepinephrine	226-240	interleukin 6	Mus musculus	99-112
11123297-0	2001	IFN-gamma production by Th1 cells generated from naive CD4+ T cells exposed to norepinephrine.	Norepinephrine	79-93	interferon gamma	Mus musculus	0-9
11164766-0	2001	NPY Y1 receptors exert opposite effects on corticotropin releasing factor and noradrenaline overflow from the rat hypothalamus in vitro.	Norepinephrine	78-91	neuropeptide Y	Rattus norvegicus	0-3
11164766-2	2001	NPY is co-localised with noradrenaline in the central nervous system and has been observed to modulate noradrenaline release.	Norepinephrine	25-38	neuropeptide Y	Rattus norvegicus	0-3
11164766-2	2001	NPY is co-localised with noradrenaline in the central nervous system and has been observed to modulate noradrenaline release.	Norepinephrine	103-116	neuropeptide Y	Rattus norvegicus	0-3
11164766-4	2001	Earlier in vivo studies in our laboratory showed a potentiation of K(+)-stimulated noradrenaline release following NPY administration, possibly due to an NPY Y1 receptor mechanism.	Norepinephrine	83-96	neuropeptide Y	Rattus norvegicus	115-118
11164766-4	2001	Earlier in vivo studies in our laboratory showed a potentiation of K(+)-stimulated noradrenaline release following NPY administration, possibly due to an NPY Y1 receptor mechanism.	Norepinephrine	83-96	neuropeptide Y	Rattus norvegicus	154-157
11164766-6	2001	Administration of 0.10 microM NPY significantly increased CRF overflow to 395% basal levels and reduced hypothalamic noradrenaline overflow to 61% of basal levels.	Norepinephrine	117-130	neuropeptide Y	Rattus norvegicus	30-33
11164766-8	2001	Thus, this study suggests that NPY, working through a Y1 receptor, has dual and opposing effects on CRF and noradrenaline overflow in vitro.	Norepinephrine	108-121	neuropeptide Y	Rattus norvegicus	31-34
11121793-15	2001	In this regard, endogenously released or exogenous VIP can significantly increase the heart rate and has a more potent effect on heart rate than does norepinephrine.	Norepinephrine	150-164	vasoactive intestinal peptide	Homo sapiens	51-54
11121814-7	2001	Prazosin reduced the maximum responses to brimonidine, shifted the concentration response curves of noradrenaline and phenylephrine rightwards giving pK(B) values of 9.86 and 9.33, respectively.	Norepinephrine	100-113	AKT serine/threonine kinase 1	Homo sapiens	150-154
11153756-9	2001	Conversely, propranolol (1 micromol/liter) and the beta1-adrenoceptor selective antagonists CPG 20712A (300 nmol/liter) or atenolol (1 micromol/liter) augmented increases in phenylalanine incorporation caused by norepinephrine.	Norepinephrine	212-226	adrenoceptor beta 1	Rattus norvegicus	51-69
11589129-14	2001	In situ hybrization histochemistry for the most recent candidate, prolactin-releasing peptide, suggests that this may involve brain stem neurons that co-localize noradrenaline.	Norepinephrine	162-175	prolactin releasing hormone	Homo sapiens	66-93
11211741-3	2001	alpha 2A adrenergic receptor knockout mouse (alpha 2A-KO) showed an increase in sympathetic activity with resting tachycardia, depletion of cardiac tissue norepinephrine concentration.	Norepinephrine	155-169	adrenergic receptor, alpha 2a	Mus musculus	0-28
11211741-3	2001	alpha 2A adrenergic receptor knockout mouse (alpha 2A-KO) showed an increase in sympathetic activity with resting tachycardia, depletion of cardiac tissue norepinephrine concentration.	Norepinephrine	155-169	adrenergic receptor, alpha 2a	Mus musculus	0-8
11475015-1	2001	Tyrosine hydroxylase (TH) is the rate limiting enzyme in the synthesis of dopamine and norepinephrine.	Norepinephrine	87-101	tyrosine hydroxylase	Homo sapiens	0-20
11475015-1	2001	Tyrosine hydroxylase (TH) is the rate limiting enzyme in the synthesis of dopamine and norepinephrine.	Norepinephrine	87-101	tyrosine hydroxylase	Homo sapiens	22-24
11164180-9	2001	RESULTS: In vitro, BK, forskolin, and sodium nitroprusside elicited dose-dependent relaxation of norepinephrine-induced tension of isolated HCC, and AN II evoked dose-dependent contraction of the HCC strips.	Norepinephrine	97-111	angiotensinogen	Homo sapiens	149-154
11145177-1	2000	Experiments were carried out to examine whether endogenous angiotensin II (A-II) is involved in the regulation of release of norepinephrine (NE) elicited by the stimulation of spinal sympathetic nerves in pithed rats.	Norepinephrine	125-139	angiotensinogen	Rattus norvegicus	59-73
11164180-9	2001	RESULTS: In vitro, BK, forskolin, and sodium nitroprusside elicited dose-dependent relaxation of norepinephrine-induced tension of isolated HCC, and AN II evoked dose-dependent contraction of the HCC strips.	Norepinephrine	97-111	kininogen 1	Homo sapiens	19-21
11530971-7	2001	Norepinephrine decreased the venous diameter at any distending pressure by increasing the P50 without significantly changing the midpoint slope.	Norepinephrine	0-14	nuclear factor kappa B subunit 1	Homo sapiens	90-93
11087233-4	2000	To this end, we first found that administration of IL-1beta in the lateral ventricle of control and CRF rats decreased blood pressure and norepinephrine (NE) secretion from the posterior hypothalamus (PH) and increased NOS mRNA expression.	Norepinephrine	138-152	interleukin 1 beta	Rattus norvegicus	51-59
11145177-1	2000	Experiments were carried out to examine whether endogenous angiotensin II (A-II) is involved in the regulation of release of norepinephrine (NE) elicited by the stimulation of spinal sympathetic nerves in pithed rats.	Norepinephrine	125-139	angiotensinogen	Rattus norvegicus	75-79
11151754-2	2000	Single photon emission computerized tomography or photon emission tomography with radioactive labeled analogues of norepinephrine have shown that cardiac sympathetic dysfunction and incompetence are early and also late abnormalities in patients with Type I (insulin-dependent) and Type II (non-insulin-dependent) diabetes mellitus.	Norepinephrine	115-129	insulin	Homo sapiens	258-265
11100982-2	2000	We previously demonstrated that atrial natriuretic factor and B- and C-type natriuretic peptides (ANF, BNP, and CNP, respectively) modified catecholamine metabolism by increasing the neuronal uptake and decreasing the neuronal release of norepinephrine in the rat hypothalamus.	Norepinephrine	238-252	natriuretic peptide B	Rattus norvegicus	103-106
11100982-3	2000	The aim of the present work was to study the effects of natriuretic peptides BNP and CNP on norepinephrine uptake as an index of the amine metabolism in discrete areas and nuclei of the central nervous system (CNS) of the rat.	Norepinephrine	92-106	natriuretic peptide B	Rattus norvegicus	77-80
11100982-6	2000	Results showed that 100 nM BNP and 1 nM CNP increased norepinephrine (NE) uptake in all brain areas and nuclei studied.	Norepinephrine	54-68	natriuretic peptide B	Rattus norvegicus	27-30
11052916-6	2000	During sodium nitroprusside infusion, forearm noradrenaline spillover increased from 1.1+/-0.3 to 2.2+/-1.0 pmol x min(-1) x 100 ml(-1) (P<0.05), whereas the forearm noradrenaline appearance rate was unchanged.	Norepinephrine	46-59	CD59 molecule (CD59 blood group)	Homo sapiens	115-121
11197783-2	2000	Insulin causes sympatho-excitation via the modification of baroreflex, norepinephrine release, or central sympathetic outflow.	Norepinephrine	71-85	insulin	Homo sapiens	0-7
11056002-1	2000	It has been well established that the key role of noradrenaline is the induction of uncoupling-protein-1 (UCP-1) expression, the unique marker of brown adipocytes.	Norepinephrine	50-63	uncoupling protein 1	Rattus norvegicus	84-104
11056002-1	2000	It has been well established that the key role of noradrenaline is the induction of uncoupling-protein-1 (UCP-1) expression, the unique marker of brown adipocytes.	Norepinephrine	50-63	uncoupling protein 1	Rattus norvegicus	106-111
11056002-3	2000	By using rat fetal brown adipocytes as a model, we show that, although noradrenaline activates extracellular regulated kinases (ERKs) through beta-, alpha1-, and alpha2-receptors, only beta-receptors mediate cell growth by a mechanism that requires ERKs activation but is independent of cyclic-adenosine-monophosphate/protein kinase A (cAMP/PKA).	Norepinephrine	71-84	cathelicidin antimicrobial peptide	Rattus norvegicus	336-340
11056002-4	2000	Conversely, the cAMP/PKA cascade mediates noradrenaline-induced UCP-1 expression, whereas ERKs pathway attenuates thermogenic differentiation.	Norepinephrine	42-55	cathelicidin antimicrobial peptide	Rattus norvegicus	16-20
11056002-4	2000	Conversely, the cAMP/PKA cascade mediates noradrenaline-induced UCP-1 expression, whereas ERKs pathway attenuates thermogenic differentiation.	Norepinephrine	42-55	uncoupling protein 1	Rattus norvegicus	64-69
11082428-9	2000	[(3)H]Nisoxetine binding to NET and NET protein levels were also reduced by exposure of cells to high concentrations of norepinephrine, although norepinephrine exposures were accompanied by changes indicative of cellular toxicity.	Norepinephrine	120-134	solute carrier family 6 member 2	Homo sapiens	28-31
11082428-9	2000	[(3)H]Nisoxetine binding to NET and NET protein levels were also reduced by exposure of cells to high concentrations of norepinephrine, although norepinephrine exposures were accompanied by changes indicative of cellular toxicity.	Norepinephrine	120-134	solute carrier family 6 member 2	Homo sapiens	36-39
11084220-4	2000	The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA.	Norepinephrine	22-35	interleukin 6	Homo sapiens	90-94
11084220-4	2000	The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA.	Norepinephrine	22-35	tumor necrosis factor	Homo sapiens	186-195
11084220-4	2000	The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA.	Norepinephrine	22-35	tumor necrosis factor	Homo sapiens	261-270
11084220-4	2000	The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA.	Norepinephrine	96-109	interleukin 6	Homo sapiens	90-94
11084220-4	2000	The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA.	Norepinephrine	96-109	tumor necrosis factor	Homo sapiens	186-195
11084220-4	2000	The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA.	Norepinephrine	96-109	tumor necrosis factor	Homo sapiens	261-270
11084220-5	2000	It is concluded that (1) noradrenaline has significant negative immunoregulatory effects in humans through suppression of the production of (monocytic) proinflammatory cytokines, e.g. IL-6 and TNF alpha, and (2) the suppression of the production of TNF alpha may be related to alpha(2)-adrenoceptor-related mechanisms.	Norepinephrine	25-38	interleukin 6	Homo sapiens	184-188
11084220-5	2000	It is concluded that (1) noradrenaline has significant negative immunoregulatory effects in humans through suppression of the production of (monocytic) proinflammatory cytokines, e.g. IL-6 and TNF alpha, and (2) the suppression of the production of TNF alpha may be related to alpha(2)-adrenoceptor-related mechanisms.	Norepinephrine	25-38	tumor necrosis factor	Homo sapiens	193-202
11084220-5	2000	It is concluded that (1) noradrenaline has significant negative immunoregulatory effects in humans through suppression of the production of (monocytic) proinflammatory cytokines, e.g. IL-6 and TNF alpha, and (2) the suppression of the production of TNF alpha may be related to alpha(2)-adrenoceptor-related mechanisms.	Norepinephrine	25-38	tumor necrosis factor	Homo sapiens	249-258
11120594-1	2000	We recently showed that clones of Th1 cells, but not Th2 cells, expressed a functional beta-2-adrenergic receptor (beta2AR) and that either norepinephrine or the beta2AR agonist terbutaline stimulated this receptor to modulate the level of Th1 cytokines produced.	Norepinephrine	140-154	negative elongation factor complex member C/D, Th1l	Mus musculus	34-37
11120594-1	2000	We recently showed that clones of Th1 cells, but not Th2 cells, expressed a functional beta-2-adrenergic receptor (beta2AR) and that either norepinephrine or the beta2AR agonist terbutaline stimulated this receptor to modulate the level of Th1 cytokines produced.	Norepinephrine	140-154	negative elongation factor complex member C/D, Th1l	Mus musculus	240-243
11082428-1	2000	Certain antidepressant and psychostimulant drugs block the uptake of norepinephrine from the synaptic cleft by inhibiting norepinephrine transporter (NET) function.	Norepinephrine	69-83	solute carrier family 6 member 2	Homo sapiens	122-148
11082428-1	2000	Certain antidepressant and psychostimulant drugs block the uptake of norepinephrine from the synaptic cleft by inhibiting norepinephrine transporter (NET) function.	Norepinephrine	69-83	solute carrier family 6 member 2	Homo sapiens	150-153
11191622-0	2000	Chronic losartan treatment decreases angiotensin II-mediated facilitation of noradrenaline release in the caudal artery of spontaneously hypertensive rats.	Norepinephrine	77-90	angiotensinogen	Rattus norvegicus	37-51
11052916-7	2000	Lower-body negative pressure did not affect the forearm noradrenaline spillover rate, but increased the forearm noradrenaline appearance rate from 3.4+/-0.4 pmol x min(-1) x 100 ml(-1) at baseline to 5.0+/-0.9 pmol x min(-1) x 100 ml(-1) (P<0.05).	Norepinephrine	112-125	CD59 molecule (CD59 blood group)	Homo sapiens	164-170
11078356-8	2000	In noradrenaline-precontracted tail arteries, 50 nM ET-1 elicited further constriction without any vasodilator effects.	Norepinephrine	3-16	endothelin 1	Rattus norvegicus	52-56
11082132-2	2000	This study was designed to evaluate the effects of aminoguanidine, a selective inhibitor of the inducible isoform of nitric oxide synthase (iNOS), on the reactivity and intracellular calcium ([Ca(2+)](i)) mobilization induced by noradrenaline in the perfused tail artery from aged WAG/Rij rats.	Norepinephrine	229-242	nitric oxide synthase 2	Rattus norvegicus	140-144
11193277-10	2000	The median norepinephrine dose at the start of the study was 0.29 microg x kg(-1) x min(-1) (range 0.07-0.48 microg x kg(-1) x min(-1)).	Norepinephrine	11-25	CD59 molecule (CD59 blood group)	Homo sapiens	84-90
11082132-22	2000	These results suggest that an inflammatory process develops in the media of the rat tail artery with age and that the subsequent increase in non-endothelial iNOS activity attenuates noradrenaline-induced vasoconstriction.	Norepinephrine	182-195	nitric oxide synthase 2	Rattus norvegicus	157-161
11029429-0	2000	The mammalian neuroendocrine hormone norepinephrine supplies iron for bacterial growth in the presence of transferrin or lactoferrin.	Norepinephrine	37-51	transferrin	Homo sapiens	106-117
11029429-2	2000	Addition of size-fractionated serum components to SAPI medium indicated that transferrin was required for norepinephrine stimulation of growth of Escherichia coli.	Norepinephrine	106-120	transferrin	Homo sapiens	77-88
11029429-3	2000	Since bacteriostasis by serum is primarily due to the iron-withholding capacity of transferrin, we considered the possibility that norepinephrine can overcome this effect by supplying transferrin-bound iron for growth.	Norepinephrine	131-145	transferrin	Homo sapiens	83-94
11029429-3	2000	Since bacteriostasis by serum is primarily due to the iron-withholding capacity of transferrin, we considered the possibility that norepinephrine can overcome this effect by supplying transferrin-bound iron for growth.	Norepinephrine	131-145	transferrin	Homo sapiens	184-195
11029429-4	2000	Incubation with concentrations of norepinephrine that stimulated bacterial growth in serum-SAPI medium resulted in loss of bound iron from iron-saturated transferrin, as indicated by the appearance of monoferric and apo- isoforms upon electrophoresis in denaturing gels.	Norepinephrine	34-48	transferrin	Homo sapiens	154-165
11029429-7	2000	Norepinephrine formed stable complexes with transferrin, lactoferrin, and serum albumin.	Norepinephrine	0-14	transferrin	Homo sapiens	44-55
11029429-8	2000	Norepinephrine-transferrin and norepinephrine-lactoferrin complexes, but not norepinephrine-apotransferrin or norepinephrine-albumin complexes, stimulated bacterial growth in serum-SAPI medium in the absence of additional norepinephrine.	Norepinephrine	0-14	transferrin	Homo sapiens	15-26
11029429-9	2000	Norepinephrine-stimulated growth in medium containing (55)Fe complexed with transferrin or lactoferrin resulted in uptake of radioactivity by bacterial cells.	Norepinephrine	0-14	transferrin	Homo sapiens	76-87
11069122-0	2000	Corticotropin-releasing hormone and arginine vasopressin: mRNA and secretion are differentially regulated according to the pattern of exposure to noradrenaline in rat hypothalamic neurones.	Norepinephrine	146-159	corticotropin releasing hormone	Rattus norvegicus	0-31
11054234-2	2000	The vasoactive peptide neuropeptide Y (NPY) is co-released with and potentiates the pressor effects of norepinephrine through the Y-1 receptor.	Norepinephrine	103-117	neuropeptide Y	Rattus norvegicus	23-37
11054234-2	2000	The vasoactive peptide neuropeptide Y (NPY) is co-released with and potentiates the pressor effects of norepinephrine through the Y-1 receptor.	Norepinephrine	103-117	neuropeptide Y	Rattus norvegicus	39-42
11069122-0	2000	Corticotropin-releasing hormone and arginine vasopressin: mRNA and secretion are differentially regulated according to the pattern of exposure to noradrenaline in rat hypothalamic neurones.	Norepinephrine	146-159	arginine vasopressin	Rattus norvegicus	45-56
11069122-1	2000	Hypothalamic corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) are secreted from the median eminence in a pulsatile manner and regulated by noradrenaline during stress.	Norepinephrine	159-172	corticotropin releasing hormone	Rattus norvegicus	13-44
11069122-1	2000	Hypothalamic corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) are secreted from the median eminence in a pulsatile manner and regulated by noradrenaline during stress.	Norepinephrine	159-172	corticotropin releasing hormone	Rattus norvegicus	46-49
11069122-1	2000	Hypothalamic corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) are secreted from the median eminence in a pulsatile manner and regulated by noradrenaline during stress.	Norepinephrine	159-172	arginine vasopressin	Rattus norvegicus	64-75
11069122-1	2000	Hypothalamic corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) are secreted from the median eminence in a pulsatile manner and regulated by noradrenaline during stress.	Norepinephrine	159-172	arginine vasopressin	Rattus norvegicus	77-80
11034950-1	2000	BACKGROUND: Inhibition of dopamine beta-hydroxylase (DBH) results in a decrease in norepinephrine synthesis.	Norepinephrine	83-97	dopamine beta-hydroxylase	Canis lupus familiaris	26-51
11027216-2	2000	Recent studies reveal that dopamine (DA), norepinephrine (NE), and serotonin (5-HT) transporters (DAT, NET, and SERT, respectively) are rapidly regulated by direct or receptor-mediated activation of cellular kinases, particularly protein kinase C (PKC).	Norepinephrine	42-56	solute carrier family 6 member 4	Homo sapiens	112-116
11034950-1	2000	BACKGROUND: Inhibition of dopamine beta-hydroxylase (DBH) results in a decrease in norepinephrine synthesis.	Norepinephrine	83-97	dopamine beta-hydroxylase	Canis lupus familiaris	53-56
11372422-4	2000	Angiotensin II (AII), endothelin-1 (ET-1) and norepinephrine(NE) can inhibit NOS activity and NO production, and induce hypertrophic response in cultured neonatal rat cardiomyocytes; these effects of AII, ET-1 and NE are mediated respectively by AII receptor, ETA receptor and alpha 1-adrenergic receptor; these effects of AII and ET-1 are mediated by PTX-sensitive G protein, while the effects of NE are mediated by PTX-insensitive G protein.	Norepinephrine	46-60	angiotensinogen	Rattus norvegicus	200-203
11003990-6	2000	The intravenous injection of norepinephrine in mice decreased the expression of CD44 and CD18 on CD3(-)NK1.1(+) cells (P < 0.01) and increased the number of CD3(-)NK1.1(+) cells in PBMC (P < 0.01).	Norepinephrine	29-43	integrin beta 2	Mus musculus	89-93
11040243-1	2000	We reported that norepinephrine and angiotensin II (Ang II) activate the Ras/mitogen-activated protein (MAP) kinase pathway primarily through the generation of cytochrome P450 (CYP450) metabolites.	Norepinephrine	17-31	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	160-175
11040243-1	2000	We reported that norepinephrine and angiotensin II (Ang II) activate the Ras/mitogen-activated protein (MAP) kinase pathway primarily through the generation of cytochrome P450 (CYP450) metabolites.	Norepinephrine	17-31	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	177-183
11113623-3	2000	selectively impaired the response to noradrenaline in the prostatic portion of rat vas deferens, leaving unaffected the epididymal portion.	Norepinephrine	37-50	arginine vasopressin	Rattus norvegicus	83-86
11372422-4	2000	Angiotensin II (AII), endothelin-1 (ET-1) and norepinephrine(NE) can inhibit NOS activity and NO production, and induce hypertrophic response in cultured neonatal rat cardiomyocytes; these effects of AII, ET-1 and NE are mediated respectively by AII receptor, ETA receptor and alpha 1-adrenergic receptor; these effects of AII and ET-1 are mediated by PTX-sensitive G protein, while the effects of NE are mediated by PTX-insensitive G protein.	Norepinephrine	46-60	endothelin 1	Rattus norvegicus	205-209
11372422-4	2000	Angiotensin II (AII), endothelin-1 (ET-1) and norepinephrine(NE) can inhibit NOS activity and NO production, and induce hypertrophic response in cultured neonatal rat cardiomyocytes; these effects of AII, ET-1 and NE are mediated respectively by AII receptor, ETA receptor and alpha 1-adrenergic receptor; these effects of AII and ET-1 are mediated by PTX-sensitive G protein, while the effects of NE are mediated by PTX-insensitive G protein.	Norepinephrine	46-60	angiotensinogen	Rattus norvegicus	200-203
11372422-4	2000	Angiotensin II (AII), endothelin-1 (ET-1) and norepinephrine(NE) can inhibit NOS activity and NO production, and induce hypertrophic response in cultured neonatal rat cardiomyocytes; these effects of AII, ET-1 and NE are mediated respectively by AII receptor, ETA receptor and alpha 1-adrenergic receptor; these effects of AII and ET-1 are mediated by PTX-sensitive G protein, while the effects of NE are mediated by PTX-insensitive G protein.	Norepinephrine	46-60	angiotensinogen	Rattus norvegicus	200-203
11372422-4	2000	Angiotensin II (AII), endothelin-1 (ET-1) and norepinephrine(NE) can inhibit NOS activity and NO production, and induce hypertrophic response in cultured neonatal rat cardiomyocytes; these effects of AII, ET-1 and NE are mediated respectively by AII receptor, ETA receptor and alpha 1-adrenergic receptor; these effects of AII and ET-1 are mediated by PTX-sensitive G protein, while the effects of NE are mediated by PTX-insensitive G protein.	Norepinephrine	46-60	endothelin 1	Rattus norvegicus	205-209
10991910-2	2000	Experiments were designed to investigate the effects of the inducible nitric oxide synthase (iNOS) stimulator, lipopolysaccharide (LPS), on noradrenaline (NA) responses and on NOS activity and its expression in intact mesenteric resistance arteries (MRAs) from Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats.	Norepinephrine	140-153	nitric oxide synthase 2	Rattus norvegicus	60-91
11033316-0	2000	Spatial, cellular and temporal basis of vasopressin potentiation of norepinephrine-induced cAMP formation.	Norepinephrine	68-82	arginine vasopressin	Homo sapiens	40-51
11033316-6	2000	Analysis of the temporal constraints of vasopressin-induced potentiation revealed that pre-activation of the vasopressin V(1) receptor for 1 min yielded greater potentiation than simultaneous exposure to vasopressin and norepinephrine.	Norepinephrine	220-234	arginine vasopressin	Homo sapiens	40-51
10991910-2	2000	Experiments were designed to investigate the effects of the inducible nitric oxide synthase (iNOS) stimulator, lipopolysaccharide (LPS), on noradrenaline (NA) responses and on NOS activity and its expression in intact mesenteric resistance arteries (MRAs) from Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats.	Norepinephrine	140-153	nitric oxide synthase 2	Rattus norvegicus	93-97
10910482-7	2000	Similarly, incubation of PBMCs (T1) with plasma obtained after CPB (T2) as well as addition of IL-10 or norepinephrine in concentrations present in plasma after CPB led to a reduced lipopolysaccharide-stimulated TNF-alpha and an increased IL-10 response.	Norepinephrine	104-118	tumor necrosis factor	Homo sapiens	212-221
11001836-7	2000	Increased myocardial TGF-beta(1) and ECM protein mRNA are found in myocardial fibrosis induced by angiotensin II infusion, by noradrenaline treatment, by isoprenaline infusion, and by long-term blockade of NO synthesis.	Norepinephrine	126-139	transforming growth factor, beta 1	Rattus norvegicus	21-32
11108138-3	2000	The addition of norepinephrine (NE), isoproterenol (a beta1/beta2-adrenergic receptor (AR) agonist) and iodoclonidine (an alpha2-AR agonist) stimulated the expression of the ANG-GH fusion gene in a dose-dependent manner, whereas the addition of epinephrine and phenylephrine (alpha1-AR agonist) had no effect.	Norepinephrine	16-30	angiotensinogen	Homo sapiens	174-177
10913031-0	2000	Evidence of UCP1-independent regulation of norepinephrine-induced thermogenesis in brown fat.	Norepinephrine	43-57	uncoupling protein 1	Rattus norvegicus	12-16
10910482-11	2000	Although norepinephrine fails to induce a cytokine response in the absence of other stimuli, its administration seems to augment the antiinflammatory IL-10 response while attenuating the TNF-alpha response.	Norepinephrine	9-23	tumor necrosis factor	Homo sapiens	187-196
10900341-0	2000	Noradrenaline induces phosphorylation of ERK-2 in human peripheral blood mononuclear cells after induction of alpha(1)-adrenergic receptors.	Norepinephrine	0-13	mitogen-activated protein kinase 1	Homo sapiens	41-46
10900341-3	2000	Moreover, incubation of these activated PBMCs with noradrenaline (NA) results in enhanced phosphorylation of ERK-2, a kinase involved in the activation of many immune functions.	Norepinephrine	51-64	mitogen-activated protein kinase 1	Homo sapiens	109-114
10860763-2	2000	This study examines the molecular forms of the alpha(1)-receptor and PKC that mediate norepinephrine"s actions in cardiomyocytes; distinct approaches (activation-dependent down-regulation of PKC isoforms) and novel reagents (A61603, an alpha(1A/c)-receptor agonist) are used to resolve this issue which has been the focus of dispute in previous studies.	Norepinephrine	86-100	protein kinase C alpha	Homo sapiens	69-72
10940784-1	2000	Human adrenomedullin (AM) and human calcitonin gene-related peptide (CGRP) produced a concentration-dependent relaxation in mouse aorta, precontracted with noradrenaline.	Norepinephrine	156-169	calcitonin related polypeptide alpha	Homo sapiens	36-67
10940784-1	2000	Human adrenomedullin (AM) and human calcitonin gene-related peptide (CGRP) produced a concentration-dependent relaxation in mouse aorta, precontracted with noradrenaline.	Norepinephrine	156-169	calcitonin related polypeptide alpha	Homo sapiens	69-73
10770951-3	2000	Norepinephrine activated Erk1/2 via both beta(3) receptors and alpha(1) receptors but not via alpha(2) receptors.	Norepinephrine	0-14	mitogen-activated protein kinase 3	Homo sapiens	25-31
10931081-10	2000	RESULTS: The severity of heart failure as determined by stroke volume, left ventricular end diastolic diameter and plasma noradrenaline concentrations correlated significantly to baseline serum insulin-like growth factor-1 levels (each P < 0.05).	Norepinephrine	122-135	insulin like growth factor 1	Homo sapiens	194-222
10860763-3	2000	Norepinephrine (NE) induces a rise in diacylglycerol levels which is sustained for 24 h and is associated with the translocation (at 5 min) and down-regulation (at 24 h) of PKC delta and PKC xi (but not PKC alpha).	Norepinephrine	0-14	protein kinase C alpha	Homo sapiens	203-212
10860763-6	2000	WB-4101 (alpha(1A/c)- and alpha(1D)-receptor antagonist) and 5-methylurapidil (alpha(1A/c)-receptor antagonist) inhibit norepinephrine-dependent accumulation of inositol phosphate and diacylglycerol, down-regulation of PKC delta and PKC xi, and activation of ERK.	Norepinephrine	120-134	protein kinase C alpha	Homo sapiens	219-222
10860763-6	2000	WB-4101 (alpha(1A/c)- and alpha(1D)-receptor antagonist) and 5-methylurapidil (alpha(1A/c)-receptor antagonist) inhibit norepinephrine-dependent accumulation of inositol phosphate and diacylglycerol, down-regulation of PKC delta and PKC xi, and activation of ERK.	Norepinephrine	120-134	mitogen-activated protein kinase 1	Homo sapiens	259-262
10871293-3	2000	Norepinephrine-induced contraction was enhanced by NPY (0.1 microM).	Norepinephrine	0-14	neuropeptide Y	Rattus norvegicus	51-54
10898109-5	2000	However, COS-7 cells expressing the hNET variant Gly478Ser displayed an approximately four-fold increase in the Km for norepinephrine, while the Vmax was unaffected.	Norepinephrine	119-133	solute carrier family 6 member 2	Homo sapiens	36-40
10871310-8	2000	Thus, valsartan is a potent inhibitor of the prejunctional facilitatory effect of angiotensin II on the release of norepinephrine from peripheral sympathetic nerves.	Norepinephrine	115-129	angiotensinogen	Rattus norvegicus	82-96
10871319-1	2000	Angiotensin II (Ang II) promotes norepinephrine (NE) release from cardiac sympathetic nerve endings.	Norepinephrine	33-47	angiotensinogen	Homo sapiens	0-22
10898109-6	2000	The increase in the Km, which is equivalent to a four-fold reduction in the affinity of the variant hNET for its natural substrate norepinephrine, indicates that the glycine in position 478 is part of a substrate recognition domain.	Norepinephrine	131-145	solute carrier family 6 member 2	Homo sapiens	100-104
10848707-7	2000	In the cell model, acetylcholine (10 micromol/L), noradrenaline (1 and 10 micromol/L) and ATP (1 micromol/L) caused a significant increase in net NGF production; acetylcholine at 1 micromol/L had no effect.	Norepinephrine	50-63	nerve growth factor	Homo sapiens	146-149
10895752-5	2000	Hydroxyethylstarch was infused in two stages while maintaining mean arterial pressure, allowing a reduction in norepinephrine dose from 0.54 to 0.33 to 0.21 microgram kg-1 min-1.	Norepinephrine	111-125	CD59 molecule (CD59 blood group)	Homo sapiens	172-177
10942111-1	2000	Non-neuronal monoamine transporters OCT1, OCT2, and EMT, which are all members of the amphiphilic solute facilitator family, control signal transmission by removing released transmitters, such as dopamine, noradrenaline, adrenaline, 5-hydroxytryptamine, and histamine, from the extracellular space.	Norepinephrine	206-219	solute carrier family 22 member 1	Homo sapiens	36-40
10834930-3	2000	We now demonstrate that epinephrine as well as norepinephrine can induce IL-6 in an endothelial cell line (HMEC-1).	Norepinephrine	47-61	interleukin 6	Homo sapiens	73-77
10898549-4	2000	Spinal release of norepinephrine (NE) represented by 3-methoxy-4-hydroxyphenylglycol (MHPG)/NE ratio was enhanced by IGF-1.	Norepinephrine	18-32	insulin like growth factor 1	Homo sapiens	117-122
10797618-0	2000	Protein targeting to glycogen mRNA expression is stimulated by noradrenaline in mouse cortical astrocytes.	Norepinephrine	63-76	protein phosphatase 1, regulatory subunit 3C	Mus musculus	0-29
10816333-8	2000	These data suggest that ANG II causes an increase of noradrenaline sensitivity in the isolated portal vein of rat.	Norepinephrine	53-66	angiotensinogen	Rattus norvegicus	24-30
10844574-0	2000	Vasopressin regulation of noradrenaline release within the supraoptic nucleus.	Norepinephrine	26-39	arginine vasopressin	Homo sapiens	0-11
10844574-1	2000	The effect of electrically evoked dendritic vasopressin release on noradrenaline release into the hypothalamic supraoptic nucleus was assessed by in vivo microdialysis in conjunction with high pressure liquid chromatography and electrochemical detection.	Norepinephrine	67-80	arginine vasopressin	Homo sapiens	44-55
10844574-4	2000	These data suggest that dendritically released vasopressin facilitates noradrenaline release into the hypothalamic nucleus.	Norepinephrine	71-84	arginine vasopressin	Homo sapiens	47-58
10888263-4	2000	In parallel, BMS-191563 pretreatment inhibited norepinephrine-mediated 3H-leucine uptake (80 +/- 10% decrease: n = 6; P<0.01), whereas a significant but less pronounced effect on the endothelin-1 response (46 +/- 6% decrease: n = 6; P<0.05) was observed.	Norepinephrine	47-61	endothelin 1	Rattus norvegicus	186-198
10816333-0	2000	Short treatments of normotensive and hypertensive rats by angiotensin II and nitric oxide inhibitor induce an increase of noradrenaline sensitivity in isolated vena portae preparations.	Norepinephrine	122-135	angiotensinogen	Rattus norvegicus	58-72
10816333-5	2000	While ANG II enhanced the contractile response to noradrenaline, neither in combination with l -NAME, HOE 140 nor minoxidil prevented such an increase in the response to noradrenaline.	Norepinephrine	50-63	angiotensinogen	Rattus norvegicus	6-12
10816333-6	2000	In the presence of ergotamine, the contractile response to noradrenaline was completely blocked not only in control animals, but also in animals treated with ANG II alone or in combination with minoxidil.	Norepinephrine	59-72	angiotensinogen	Rattus norvegicus	158-164
10821718-10	2000	Its p-methoxy analogue 5c is a mixed inhibitor of norepinephrine and serotonin reuptake (K(i) = 187 nM at the NET and 56 nM at the SERT).	Norepinephrine	50-64	solute carrier family 6 member 4	Rattus norvegicus	131-135
10790163-2	2000	Intracellular dialysis with 5 microM MLCK(11-19)amide, a substrate-specific peptide inhibitor of MLCK, markedly reduced the amplitude and rate of activation of noradrenaline-evoked Icat.	Norepinephrine	160-173	myosin light chain kinase, smooth muscle	Oryctolagus cuniculus	37-41
10802036-0	2000	Systemic angiotensin II and volume expansion release norepinephrine in the preoptic recess.	Norepinephrine	53-67	angiotensinogen	Rattus norvegicus	9-23
10802036-4	2000	infusion of ang II and volume expansion increase norepinephrine release in the AV3V area using in vivo microdialysis.	Norepinephrine	49-63	angiotensinogen	Rattus norvegicus	12-18
10802036-10	2000	infusion of ang II and isotonic volume expansion significantly increased dialysate norepinephrine concentration, while infusion of phenylephrine did not alter norepinephrine release in AV3V tissue.	Norepinephrine	83-97	angiotensinogen	Rattus norvegicus	12-18
10802036-11	2000	These data demonstrate that peripheral ang II and volume expansion selectively increase norepinephrine release in the AV3V region, and are consistent with the conclusion that activation of noradrenergic systems in the AV3V region contribute to cardiovascular and drinking responses evoked by peripheral ang II and to natriuresis following volume expansion.	Norepinephrine	88-102	angiotensinogen	Rattus norvegicus	39-45
10790163-0	2000	Evidence for myosin light chain kinase mediating noradrenaline-evoked cation current in rabbit portal vein myocytes.	Norepinephrine	49-62	myosin light chain kinase, smooth muscle	Oryctolagus cuniculus	13-38
10780931-4	2000	Norepinephrine (NE) increases UCP mRNA during differentiation, not during proliferation.	Norepinephrine	0-14	uncoupling protein 1	Rattus norvegicus	30-33
10781290-4	2000	Sevoflurane still enhanced the norepinephrine response after inhibitions of the nitric oxide, endothelium-derived hyperpolarizing factor, cyclooxygenase and lipoxygenase pathways, or after blockade of either endothelin-1 ET-1), angiotensin-II, or sevotonin receptors.	Norepinephrine	31-45	endothelin 1	Rattus norvegicus	208-220
10781290-4	2000	Sevoflurane still enhanced the norepinephrine response after inhibitions of the nitric oxide, endothelium-derived hyperpolarizing factor, cyclooxygenase and lipoxygenase pathways, or after blockade of either endothelin-1 ET-1), angiotensin-II, or sevotonin receptors.	Norepinephrine	31-45	angiotensinogen	Rattus norvegicus	228-242
10790163-1	2000	The role of myosin light chain kinase (MLCK) in the activation of the noradrenaline-evoked non-selective cation current (Icat) was examined with the whole-cell recording technique in single rabbit portal vein smooth muscle cells.	Norepinephrine	70-83	myosin light chain kinase, smooth muscle	Oryctolagus cuniculus	12-37
10790163-1	2000	The role of myosin light chain kinase (MLCK) in the activation of the noradrenaline-evoked non-selective cation current (Icat) was examined with the whole-cell recording technique in single rabbit portal vein smooth muscle cells.	Norepinephrine	70-83	myosin light chain kinase, smooth muscle	Oryctolagus cuniculus	39-43
10790163-2	2000	Intracellular dialysis with 5 microM MLCK(11-19)amide, a substrate-specific peptide inhibitor of MLCK, markedly reduced the amplitude and rate of activation of noradrenaline-evoked Icat.	Norepinephrine	160-173	myosin light chain kinase, smooth muscle	Oryctolagus cuniculus	97-101
10790163-4	2000	Inhibitors of binding of ATP to MLCK, wortmannin and synthetic naphthalenesulphonyl derivatives (ML-7 and ML-9), at micromolar concentrations, also reduced the amplitude of noradrenaline-evoked Icat.	Norepinephrine	173-186	myosin light chain kinase, smooth muscle	Oryctolagus cuniculus	32-36
10790163-10	2000	The results indicate that MLCK mediates noradrenaline-activated Icat in rabbit portal vein smooth muscle cells.	Norepinephrine	40-53	myosin light chain kinase, smooth muscle	Oryctolagus cuniculus	26-30
10766931-5	2000	Prenatal hypoxia decreased the dopamine content in the carotid bodies at all ages, and decreased the utilisation rate of noradrenaline in the caudal part of the A2 (A2c), A1 and A5 noradrenergic brainstem cell groups at 3 weeks after birth.	Norepinephrine	121-134	UDP glucuronosyltransferase 1 family, polypeptide A7C	Rattus norvegicus	161-163
10764411-7	2000	Norepinephrine-induced vasoconstriction was decreased in WT septic mice (EC(50) 200+/-56 nmol/L) compared with WT and iNOS-deficient shams (16+/-4 and 13+/-6 nmol/L), and vasoconstriction was significantly improved in septic iNOS-deficient mice (35+/-13 nmol/L, P<0.01).	Norepinephrine	0-14	nitric oxide synthase 2, inducible	Mus musculus	118-122
10771134-14	2000	Soluble melanins formed from dopa, or dopamine, or norepinephrine in weak alkaline solution have been shown to be toxic to human CD4+ lymphoblastic cells (MT-2) at higher than 10 microg/ml concentrations.	Norepinephrine	51-65	CD4 molecule	Homo sapiens	129-132
10766931-5	2000	Prenatal hypoxia decreased the dopamine content in the carotid bodies at all ages, and decreased the utilisation rate of noradrenaline in the caudal part of the A2 (A2c), A1 and A5 noradrenergic brainstem cell groups at 3 weeks after birth.	Norepinephrine	121-134	UDP glucuronosyltransferase 1 family, polypeptide A7C	Rattus norvegicus	165-168
10809289-9	2000	Mean +/- SEM norepinephrine plasma concentrations in the vasopressin animals in comparison with placebo were at 1.5 and 5 mins after drug administration significantly lower (41729+/-13918 vs. 82756+/-9904 pg/mL [p = .01] and 10642+/-3193 vs. 62170+/-8797 pg/mL [p < .01]).	Norepinephrine	13-27	vasopressin	Sus scrofa	57-68
10797820-10	2000	DISCUSSION: We reported a refractory shock to fluid challenges and norepinephrine after the first dose of ACE inhibitor during acute myocardial infarction.	Norepinephrine	67-81	angiotensin I converting enzyme	Homo sapiens	106-109
10780975-1	2000	Simultaneous measurements of intracellular calcium concentration ([Ca(2+)](i)) and tension were performed to clarify whether the mechanisms which cause the neuropeptide Y (NPY)-elicited contraction and potentiation of noradrenaline contractions, and the NPY inhibition of forskolin responses are linked to a single or different NPY receptor(s) in rat mesenteric small arteries.	Norepinephrine	218-231	neuropeptide Y	Rattus norvegicus	156-170
10780975-1	2000	Simultaneous measurements of intracellular calcium concentration ([Ca(2+)](i)) and tension were performed to clarify whether the mechanisms which cause the neuropeptide Y (NPY)-elicited contraction and potentiation of noradrenaline contractions, and the NPY inhibition of forskolin responses are linked to a single or different NPY receptor(s) in rat mesenteric small arteries.	Norepinephrine	218-231	neuropeptide Y	Rattus norvegicus	172-175
10780975-4	2000	NPY (0.1 microM) caused a near 3 fold increase in sensitivity to noradrenaline but did not significantly modify the tension-[Ca(2+)](i) relationship for this agonist.	Norepinephrine	65-78	neuropeptide Y	Rattus norvegicus	0-3
10780975-5	2000	BIBP 3226 competitively antagonized the contractile response to NPY in arteries submaximally preconstricted with noradrenaline (pA(2) 7.87+/-0.20).	Norepinephrine	113-126	neuropeptide Y	Rattus norvegicus	64-67
10784001-0	2000	Neuropeptide Y and peptide YY, but not pancreatic polypeptide, substance P, cholecystokinin and gastric inhibitory polypeptide, inhibit the glucagon- and noradrenaline-dependent increase in glucose output in rat liver.	Norepinephrine	154-167	neuropeptide Y	Rattus norvegicus	0-29
10784001-7	2000	NPY and PYY, but not PP, SP, CCK or GIP, inhibited the increase in glucose release by glucagon and noradrenaline.	Norepinephrine	99-112	neuropeptide Y	Rattus norvegicus	0-3
10784001-9	2000	Only portal NPY and PYY enhanced slightly the noradrenaline-dependent reduction of portal flow.	Norepinephrine	46-59	neuropeptide Y	Rattus norvegicus	12-15
10784001-11	2000	NPY and PYY act as signal factors of the absorptive phase function as antagonists of the postabsorptive glucose regulatory hormones glucagon and noradrenaline.	Norepinephrine	145-158	neuropeptide Y	Rattus norvegicus	0-3
10752952-1	2000	PURPOSE: To determine the cholinergic (carbachol, CCH) and adrenergic (norepinephrine, NE) modulation of Ca2+ response to endothelin-1 in human ciliary smooth muscle (HCSM) cells.	Norepinephrine	71-85	endothelin 1	Homo sapiens	122-134
10742288-8	2000	The selective alpha(2)-adrenoceptor ligand rauwolscine antagonized acidification rate changes with an affinity independent of the agonist used; the affinity (mean pK(B)) against noradrenaline was 8.43.	Norepinephrine	178-191	AKT serine/threonine kinase 1	Homo sapiens	163-168
10752952-6	2000	Norepinephrine pretreatment also decreased ET-1-induced [Ca2+]i (10 microM NE + ET-1; 619 +/- 64 nM) compared with ET-1 alone, and NE"s effect could be reversed by propranolol (beta-adrenergic antagonist) treatment.	Norepinephrine	0-14	endothelin 1	Homo sapiens	43-47
10752952-6	2000	Norepinephrine pretreatment also decreased ET-1-induced [Ca2+]i (10 microM NE + ET-1; 619 +/- 64 nM) compared with ET-1 alone, and NE"s effect could be reversed by propranolol (beta-adrenergic antagonist) treatment.	Norepinephrine	0-14	endothelin 1	Homo sapiens	80-84
10752952-6	2000	Norepinephrine pretreatment also decreased ET-1-induced [Ca2+]i (10 microM NE + ET-1; 619 +/- 64 nM) compared with ET-1 alone, and NE"s effect could be reversed by propranolol (beta-adrenergic antagonist) treatment.	Norepinephrine	0-14	endothelin 1	Homo sapiens	80-84
10734146-6	2000	Both the alpha(2A)- and alpha(2C)-subtypes are important in the presynaptic inhibition of norepinephrine release and appear to have distinct regulatory roles.	Norepinephrine	90-104	adrenergic receptor, alpha 2a	Mus musculus	9-17
10704276-0	2000	Somatostatin inhibits the release of noradrenaline induced by electrical stimulation of the rat mesenteric artery.	Norepinephrine	37-50	somatostatin	Rattus norvegicus	0-12
10704276-1	2000	Somatostatin, a peptide with antisecretory and antiproliferative effects, coexists with noradrenaline in sympathetic neurons.	Norepinephrine	88-101	somatostatin	Rattus norvegicus	0-12
10704276-7	2000	The maximal effects produced by octreotide and somatostatin were a 56 and 70% inhibition of noradrenaline release, respectively.	Norepinephrine	92-105	somatostatin	Rattus norvegicus	47-59
10870213-0	2000	[Intracellular cAMP involvement in the synchronized activity of noradrenaline in response to evoked release of the transmitter quanta in the frog synapses].	Norepinephrine	64-77	cathelicidin antimicrobial peptide	Canis lupus familiaris	15-19
10753283-9	2000	Arteries in the presence of superoxide dismutase and catalase had similarly impaired reactivity to norepinephrine as did homocysteine arteries (EC(50), 0.58 +/- 0.15 micromol/L; P >.05 vs HC, P <.01 vs control).	Norepinephrine	99-113	catalase	Homo sapiens	53-61
10870213-3	2000	Action of noradrenaline on the time course of the secretion seems to be realised through activation of presynaptic beta-adrenoreceptors, augmentation of the adenylyl cyclase activity, and the rise of the intracellular cAMP.	Norepinephrine	10-23	cathelicidin antimicrobial peptide	Canis lupus familiaris	218-222
10704782-0	2000	Hippocampal norepinephrine-like voltammetric responses following infusion of corticotropin-releasing factor into the locus coeruleus.	Norepinephrine	12-26	corticotropin releasing hormone	Rattus norvegicus	77-107
10700658-3	2000	This effect involves sympathetic nervous system (SNS) activation, since CRH-treatment resulted in a marked increase in plasma norepinephrine (NE) and epinephrine (E), and sympathetic blockade by subcutaneously injected atenolol (1 mg/kg), a beta1-selective adrenergic antagonist, completely prevented the CRH-induced tachycardia.	Norepinephrine	126-140	corticotropin releasing hormone	Rattus norvegicus	72-75
10720601-15	2000	min(-1) per 1.73 m(2) during the first norepinephrine infusion, without subsequent change.	Norepinephrine	39-53	CD59 molecule (CD59 blood group)	Homo sapiens	0-6
10731686-0	2000	Norepinephrine stimulates interleukin-6 mRNA expression in primary cultured rat hepatocytes.	Norepinephrine	0-14	interleukin 6	Rattus norvegicus	26-39
10823386-3	2000	MAIN RESULTS: Catecholamines (epinephrine, norepinephrine, isoproterenol, and dopamine) in general inhibit tumor necrosis factor-alpha (TNF) production and may enhance interleukin-6 (IL-6) and IL-10 production.	Norepinephrine	43-57	tumor necrosis factor	Homo sapiens	107-134
10823386-3	2000	MAIN RESULTS: Catecholamines (epinephrine, norepinephrine, isoproterenol, and dopamine) in general inhibit tumor necrosis factor-alpha (TNF) production and may enhance interleukin-6 (IL-6) and IL-10 production.	Norepinephrine	43-57	tumor necrosis factor	Homo sapiens	136-139
10823386-3	2000	MAIN RESULTS: Catecholamines (epinephrine, norepinephrine, isoproterenol, and dopamine) in general inhibit tumor necrosis factor-alpha (TNF) production and may enhance interleukin-6 (IL-6) and IL-10 production.	Norepinephrine	43-57	interleukin 6	Homo sapiens	168-181
10686300-7	2000	pre-treatment of rats with alpha-helical CRH significantly reduced the conditioned-fear-induced tachycardiac and ACTH response, and enhanced the increase in PQ interval, without affecting the noradrenaline and adrenaline response.	Norepinephrine	192-205	corticotropin releasing hormone	Rattus norvegicus	41-44
10974417-10	2000	Norepinephrine bolus during concurrent alpha(1) and alpha(2)-AR blockade produced significant (p < 0.001) hypotensive responses in all subgroups, presumably attributable to unopposed stimulation of beta(2)-vascular wall ARs.	Norepinephrine	0-14	adrenergic receptor, alpha 2a	Mus musculus	52-63
10702208-4	2000	RESULTS: In all groups, ANG II and norepinephrine caused dose-dependent reductions in FBF (P < 0.001); responses to norepinephrine were similar across the 3 groups but those to ANG II were less in both cirrhotic groups than in controls (P < 0.01).	Norepinephrine	35-49	angiotensinogen	Homo sapiens	180-186
10675734-4	2000	Somatostatin (10(-8)-10(-4) M) produced a concentration-dependent inhibition of the contractile responses induced by high K(+) (80 mM) or noradrenaline (10(-6) M in aorta or 10(-4) M in mesenteric arteries) in both arteries studied.	Norepinephrine	138-151	somatostatin	Oryctolagus cuniculus	0-12
10675734-5	2000	The inhibitory effect of somatostatin was greater in mesenteric resistance vessels (IC(50) 3.1+/-2.3x10(-5) M, and 5.2+/-4.8x10(-8) M with KCl and noradrenaline, respectively).	Norepinephrine	147-160	somatostatin	Oryctolagus cuniculus	25-37
10675734-7	2000	Furthermore, somatostatin decreased noradrenaline-induced contraction attributed to intracellular Ca(2+) release in aorta, and inhibited 45Ca(2+) uptake stimulated by high K(+) or by noradrenaline.	Norepinephrine	36-49	somatostatin	Oryctolagus cuniculus	13-25
10675734-7	2000	Furthermore, somatostatin decreased noradrenaline-induced contraction attributed to intracellular Ca(2+) release in aorta, and inhibited 45Ca(2+) uptake stimulated by high K(+) or by noradrenaline.	Norepinephrine	183-196	somatostatin	Oryctolagus cuniculus	13-25
10731686-6	2000	In the present study, using rat primary cultured hepatocytes and non-parenchymal liver cells, the effect of norepinephrine (NE) on IL-6 mRNA expression was determined.	Norepinephrine	108-122	interleukin 6	Rattus norvegicus	131-135
10888271-5	2000	We now demonstrate that, in addition to histamine, melatonin and the biogenic amines dopamine, serotonin and noradrenaline bind to P450 isozymes and to cytochrome C.	Norepinephrine	109-122	cytochrome c, somatic	Homo sapiens	152-164
10674987-2	2000	We found that reduction of the sympathetic outflow by reserpine dramatically increased the lipopolysaccharide (LPS)-induced TNF-alpha production, demonstrating that the release of endogenous noradrenaline (NA), controlled by presynaptic alpha2-adrenoceptors, was a determinant factor in this model.	Norepinephrine	191-204	tumor necrosis factor	Mus musculus	124-133
10685879-7	2000	Procaine also inhibited uptake of norepinephrine (NE) and serotonin (5-HT) by the norepinephrine transporter (NET) or serotonin transporter (SERT) expressed in COS cells.	Norepinephrine	34-48	solute carrier family 6 member 4	Rattus norvegicus	118-139
10685879-7	2000	Procaine also inhibited uptake of norepinephrine (NE) and serotonin (5-HT) by the norepinephrine transporter (NET) or serotonin transporter (SERT) expressed in COS cells.	Norepinephrine	34-48	solute carrier family 6 member 4	Rattus norvegicus	141-145
10691803-5	2000	The antinatriuretic effects of noradrenaline, acting on alpha-adrenoceptors and angiotensin II are opposed by dopamine as well as by atrial natriuretic peptide (ANP).	Norepinephrine	31-44	angiotensinogen	Homo sapiens	80-94
10728367-7	2000	Noradrenaline (10(-8)-10(-4) M) contraction was not modified by endothelin-1 (3 x 10(-9) M) or vasopressin (3 x 10(-11) M), and contraction to endothelin-1 (10(-9)-10(-7) M) and vasopressin (10(-10)-10(-7) M) was lower in arteries from SHR than from WKY rats.	Norepinephrine	0-13	arginine vasopressin	Rattus norvegicus	178-189
10728367-8	2000	CONCLUSIONS: (1) The potentiation by endothelin-1 and vasopressin of the sympathetic vasoconstriction, probably due to increased release of noradrenaline, is impaired during hypertension, and (2) this potentiation is mediated mainly by endothelin ETA receptors, and by vasopressin V1 receptors, in both WKY and SHR, and for both peptides it is mediated by L-type calcium channels in arteries from normotensive but not in those from hypertensive animals.	Norepinephrine	140-153	endothelin 1	Rattus norvegicus	37-49
10728367-8	2000	CONCLUSIONS: (1) The potentiation by endothelin-1 and vasopressin of the sympathetic vasoconstriction, probably due to increased release of noradrenaline, is impaired during hypertension, and (2) this potentiation is mediated mainly by endothelin ETA receptors, and by vasopressin V1 receptors, in both WKY and SHR, and for both peptides it is mediated by L-type calcium channels in arteries from normotensive but not in those from hypertensive animals.	Norepinephrine	140-153	arginine vasopressin	Rattus norvegicus	54-65
10789691-4	2000	Therefore, the present study employs microdialysis to study the local effects of exogenous angiotensin II on the interstitial norepinephrine concentration of the normally innervated left ventricle of the anaesthetised rat.	Norepinephrine	126-140	angiotensinogen	Rattus norvegicus	91-105
10789691-5	2000	The present study investigates the effect of increasing dosages of exogenous angiotensin II on local interstitial norepinephrine.	Norepinephrine	114-128	angiotensinogen	Rattus norvegicus	77-91
10789691-10	2000	Angiotensin II induced a dose dependent increase in norepinephrine that was significantly reduced by losartan.	Norepinephrine	52-66	angiotensinogen	Rattus norvegicus	0-14
10789691-13	2000	The data strongly suggest that AT1 receptors are involved in this interaction, since selective AT1 receptor blockade with losartan significantly reduced the angiotensin II induced norepinephrine concentration.	Norepinephrine	180-194	angiotensinogen	Rattus norvegicus	157-171
10691803-5	2000	The antinatriuretic effects of noradrenaline, acting on alpha-adrenoceptors and angiotensin II are opposed by dopamine as well as by atrial natriuretic peptide (ANP).	Norepinephrine	31-44	natriuretic peptide A	Homo sapiens	133-159
10691803-5	2000	The antinatriuretic effects of noradrenaline, acting on alpha-adrenoceptors and angiotensin II are opposed by dopamine as well as by atrial natriuretic peptide (ANP).	Norepinephrine	31-44	natriuretic peptide A	Homo sapiens	161-164
11268388-6	2000	LPC 18:0 synergistically increases IL-6 release in the presence of norepinephrine, and IL-1 beta transiently increases LPC 18:0 formation in C6 cells.	Norepinephrine	67-81	interleukin 6	Homo sapiens	35-39
10970992-4	2000	TNF concentrations were significantly correlated with the 24-hour excretion of epinephrine and norepinephrine (r = 0.64 and 0.69; each p < 0.01).	Norepinephrine	95-109	tumor necrosis factor	Homo sapiens	0-3
11268424-3	2000	Recent evidence indicates that glucocorticoids, norepinephrine, epinephrine, histamine, and adenosine inhibit the production of human IL-12 and TNF-alpha, whereas they do not affect or even stimulate the production of IL-10.	Norepinephrine	48-62	tumor necrosis factor	Homo sapiens	144-153
10654495-6	2000	The administration of vasopressin (0.09+/-0.05 U/min) increased mean arterial pressure (58+/-13 to 75+/-14 mm Hg; p<0.001) while reducing norepinephrine administration (11.7+/-13 to 7.9+/-6.0 mcg/min; p = 0.023).	Norepinephrine	141-155	arginine vasopressin	Homo sapiens	22-33
11193127-1	2000	OBJECTIVE: We have studied possible association between predisposition to essential hypertension, plasma noradrenaline level and two polymorphisms of the gene for tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine biosynthesis.	Norepinephrine	105-118	tyrosine hydroxylase	Homo sapiens	163-183
11193127-1	2000	OBJECTIVE: We have studied possible association between predisposition to essential hypertension, plasma noradrenaline level and two polymorphisms of the gene for tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine biosynthesis.	Norepinephrine	105-118	tyrosine hydroxylase	Homo sapiens	185-187
11193127-10	2000	Nevertheless, some genotypes of TH might be related to disturbance of plasma noradrenaline concentration.	Norepinephrine	77-90	tyrosine hydroxylase	Homo sapiens	32-34
11149624-9	2000	Norepinephrine levels increased from 1.25+/-0.09 to 1.58+/-0.12 nmol/l during insulin infusion and remained unchanged during placebo infusion (1.24+/-0.09 vs. 1.29+/-0.11 pmol/l; p<0.001).	Norepinephrine	0-14	insulin	Homo sapiens	78-85
10741758-3	2000	In rats, norepinephrine (NE) induced elevations in arterial glucose content were inhibited by NO synthase antagonism (N(omega)-nitro-L-arginine methyl ester (L-NAME), 10 mg/kg, intraportal) but potentiated by NO donor administration (3-morpholinosydnonimine (SIN-1), 0.2 mg/kg, intraportal).	Norepinephrine	9-23	MAPK associated protein 1	Homo sapiens	259-264
10610744-10	2000	04) and norepinephrine (P=0.04) were univariately associated with increased angiotensin II.	Norepinephrine	8-22	angiotensinogen	Homo sapiens	76-90
10610744-11	2000	Multivariate regression analysis identified the plasma renin activity (0.0004), norepinephrine (0.02) and interleukin-6 (0.03) as independent predictors of plasma angiotensin II.	Norepinephrine	80-94	angiotensinogen	Homo sapiens	163-177
10642341-1	2000	We recently reported that norepinephrine and angiotensin II activate the Ras/mitogen-activated protein (MAP) kinase pathway through generation of a cytochrome P450 (CYP450) and lipoxygenase metabolites.	Norepinephrine	26-40	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	148-163
10629458-8	2000	A small decrease in IFN-gamma production and an increase in IL-10, IL-4, and IL-5 production were also observed with norepinephrine.	Norepinephrine	117-131	interferon gamma	Homo sapiens	20-29
10629458-8	2000	A small decrease in IFN-gamma production and an increase in IL-10, IL-4, and IL-5 production were also observed with norepinephrine.	Norepinephrine	117-131	interleukin 4	Homo sapiens	67-71
11206730-0	2000	Biphasic inotropic response to endothelin-1 in the presence of various concentrations of norepinephrine in dog ventricular myocardium.	Norepinephrine	89-103	endothelin 1	Canis lupus familiaris	31-43
10642341-1	2000	We recently reported that norepinephrine and angiotensin II activate the Ras/mitogen-activated protein (MAP) kinase pathway through generation of a cytochrome P450 (CYP450) and lipoxygenase metabolites.	Norepinephrine	26-40	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	165-171
10965233-4	2000	Acute, systemic IL-2 (0.55-17.6 x 10(3) IU) did not influence plasma adrenocorticotropic hormone or corticosterone levels, but increased the utilization of norepinephrine (NE) within the paraventricular nucleus of the hypothalamus.	Norepinephrine	156-170	interleukin 2	Homo sapiens	16-20
10658614-0	2000	Impaired recovery of noradrenaline levels in apolipoprotein E-deficient mice after N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine lesion.	Norepinephrine	21-34	apolipoprotein E	Mus musculus	45-61
11452226-5	2000	RESULTS: We found that 1) noradrenaline, 10-5 M, 10-6 M, and 10-7 M, significantly suppressed the production of IFNgamma and that noradrenaline, 10-5 M, significantly enhanced the production of IL-10.	Norepinephrine	26-39	interferon gamma	Homo sapiens	112-120
11452226-7	2000	Noradrenaline, 10-5 M and 10-6 M, and clonidine, 10-5 M, significantly suppressed the IFNgamma/IL-10 production ratio.	Norepinephrine	0-13	interferon gamma	Homo sapiens	86-94
10670458-6	2000	At higher doses of noradrenaline, there was alpha1-adrenoceptor-mediated inhibition of memory consolidation.	Norepinephrine	19-32	asparagine-linked glycosylation 12, alpha-1,6-mannosyltransferase homolog (S. cerevisiae)	Gallus gallus	44-50
11452226-9	2000	CONCLUSIONS: 1) noradrenaline has significant negative immunoregulatory effects in humans through enhancing the production of IL-10 and suppressing that of IFNgamma; and 2) the suppression of the production of IFNgamma is in part related to alpha2-adrenoceptor activation.	Norepinephrine	16-29	interferon gamma	Homo sapiens	156-171
11452226-9	2000	CONCLUSIONS: 1) noradrenaline has significant negative immunoregulatory effects in humans through enhancing the production of IL-10 and suppressing that of IFNgamma; and 2) the suppression of the production of IFNgamma is in part related to alpha2-adrenoceptor activation.	Norepinephrine	16-29	interferon gamma	Homo sapiens	156-164
10658614-2	2000	Apolipoprotein E-deficient mice had lower hippocampal noradrenaline levels than control mice.	Norepinephrine	54-67	apolipoprotein E	Mus musculus	0-16
10642831-1	1999	We aimed at characterizing the receptor subtype and the signaling pathway involved in the inhibitory effect of neuropeptide Y on the release of endogenous noradrenaline from rat hypothalamus.	Norepinephrine	155-168	neuropeptide Y	Rattus norvegicus	111-125
10642831-4	1999	Neuropeptide Y inhibited concentration dependently the stimulated noradrenaline release.	Norepinephrine	66-79	neuropeptide Y	Rattus norvegicus	0-14
10642831-0	1999	Neuropeptide Y induced inhibition of noradrenaline release in rat hypothalamus: role of receptor subtype and nitric oxide.	Norepinephrine	37-50	neuropeptide Y	Rattus norvegicus	0-14
10642831-5	1999	Similarly, agonists for neuropeptide Y Y1, Y2 and Y5 receptors inhibited noradrenaline release, albeit with a potency lower than neuropeptide Y.	Norepinephrine	73-86	neuropeptide Y	Rattus norvegicus	24-38
10642831-9	1999	NG-monomethyl-L-arginine, an inhibitor of nitric oxide synthase, abolished NO release and blocked the inhibitory effect of neuropeptide Y on noradrenaline release.	Norepinephrine	141-154	neuropeptide Y	Rattus norvegicus	123-137
10585891-4	1999	The noradrenaline- and KCl-induced vasoconstrictions of human renal interlobular arteries were unaffected by the presence of L-NAME, but were attenuated by EPO (20 units.ml(-1)) by some 33% (P<0.01); this effect was enhanced by the co-administration of L-NAME.	Norepinephrine	4-17	erythropoietin	Homo sapiens	156-159
10585338-1	1999	BACKGROUND: Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of the catecholamines dopamine, norepinephrine, and epinephrine.	Norepinephrine	123-137	tyrosine hydroxylase	Homo sapiens	12-32
10585338-1	1999	BACKGROUND: Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of the catecholamines dopamine, norepinephrine, and epinephrine.	Norepinephrine	123-137	tyrosine hydroxylase	Homo sapiens	34-36
10657739-0	1999	Chronic ventromedial hypothalamic infusion of norepinephrine and serotonin promotes insulin resistance and glucose intolerance.	Norepinephrine	46-60	insulin	Homo sapiens	84-91
10585891-3	1999	In human subcutaneous arteries from uraemic subjects, noradrenaline- and KCl-induced vasoconstrictions were enhanced when nitric oxide (NO) production was blocked with N(G)-nitro-L-arginine methyl ester (L-NAME), but were unaffected by EPO, while acetylcholine- and bradykinin-induced concentration-dependent relaxations were markedly attenuated by L-NAME, but not by EPO.	Norepinephrine	54-67	erythropoietin	Homo sapiens	236-239
10585891-3	1999	In human subcutaneous arteries from uraemic subjects, noradrenaline- and KCl-induced vasoconstrictions were enhanced when nitric oxide (NO) production was blocked with N(G)-nitro-L-arginine methyl ester (L-NAME), but were unaffected by EPO, while acetylcholine- and bradykinin-induced concentration-dependent relaxations were markedly attenuated by L-NAME, but not by EPO.	Norepinephrine	54-67	kininogen 1	Homo sapiens	266-276
10585891-3	1999	In human subcutaneous arteries from uraemic subjects, noradrenaline- and KCl-induced vasoconstrictions were enhanced when nitric oxide (NO) production was blocked with N(G)-nitro-L-arginine methyl ester (L-NAME), but were unaffected by EPO, while acetylcholine- and bradykinin-induced concentration-dependent relaxations were markedly attenuated by L-NAME, but not by EPO.	Norepinephrine	54-67	erythropoietin	Homo sapiens	368-371
10961737-8	1999	The facilitated noradrenaline release by angiotensin II and bradykinin was blocked by the angiotensin receptor antagonist saralasin to the same extent.	Norepinephrine	16-29	angiotensinogen	Rattus norvegicus	41-55
10600926-8	1999	In other conscious rats, a high dose of orexin-A and -B increased plasma norepinephrine.	Norepinephrine	73-87	hypocretin neuropeptide precursor	Rattus norvegicus	40-55
10657739-2	1999	We and others have shown that activities, or extracellular metabolites of norepinephrine (NE) and serotonin (5-HT) are elevated in the VMH of both genetically and seasonally insulin-resistant and glucose-intolerant animals.	Norepinephrine	74-88	insulin	Homo sapiens	174-181
10597901-10	1999	Adrenaline and noradrenaline did not significantly prevent the inactivation of ADH and very slightly inhibited GAPDH.	Norepinephrine	15-28	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	111-116
10612703-8	1999	The recent findings that insulin alters the expression and function of neural transporters for dopamine and norepinephrine indicate that adiposity signals may influence food intake by acting on non-peptide neurotransmitter systems.	Norepinephrine	108-122	insulin	Homo sapiens	25-32
10612709-6	1999	However, the effects of GAL on acetylcholine release and on spatial learning, which are due to activation of GAL-receptors, appear to be indirectly mediated possibly via noradrenaline transmission.	Norepinephrine	170-183	galanin and GMAP prepropeptide	Rattus norvegicus	24-27
10578236-1	1999	DOPA decarboxylase (DDC), also known as aromatic L-amino acid decarboxylase (AADC), is an enzyme involved in the synthesis of the important neurotransmitters dopamine, norepinephrine, and serotonin.	Norepinephrine	168-182	dopa decarboxylase	Homo sapiens	0-18
10553693-3	1999	In the second section, we focus on E2 and P regulation of norepinephrine (NE) neurotransmission in the HYP.	Norepinephrine	58-72	dihydrolipoamide S-succinyltransferase	Rattus norvegicus	35-43
10560022-0	1999	The role of corticotropin-releasing factor--norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress.	Norepinephrine	44-58	corticotropin releasing hormone	Rattus norvegicus	12-42
10560033-1	1999	BACKGROUND: Levels of tyrosine hydroxylase (TH) are regulated in the noradrenergic locus coeruleus (LC) in response to changes in the activity of LC neurons and in response to changes in brain levels of norepinephrine.	Norepinephrine	203-217	tyrosine hydroxylase	Homo sapiens	22-42
10560033-1	1999	BACKGROUND: Levels of tyrosine hydroxylase (TH) are regulated in the noradrenergic locus coeruleus (LC) in response to changes in the activity of LC neurons and in response to changes in brain levels of norepinephrine.	Norepinephrine	203-217	tyrosine hydroxylase	Homo sapiens	44-46
10560033-8	1999	CONCLUSIONS: Elevated expression of TH in the LC in major depression implies a premortem overactivity of these neurons, or a deficiency of the cognate transmitter, norepinephrine.	Norepinephrine	164-178	tyrosine hydroxylase	Homo sapiens	36-38
10531431-3	1999	Expression of hCB1 cannabinoid receptors abolished the Ca(2+) current inhibition by endogenous pertussis toxin-sensitive G(i/o)-coupled receptors for norepinephrine (NE) and somatostatin (SOM) but not by endogenous pertussis toxin-insensitive G(s)-coupled receptors for vasoactive intestinal polypeptide.	Norepinephrine	150-164	cannabinoid receptor 1	Homo sapiens	14-18
10647009-6	1999	Both low- and high-frequency regulation seem to be physiologically important, as mice lacking both alpha2A- and alpha2C-receptor subtypes have elevated plasma noradrenaline concentrations and develop cardiac hypertrophy with decreased left ventricular contractility by four months of age.	Norepinephrine	159-172	adrenergic receptor, alpha 2a	Mus musculus	99-106
10513987-3	1999	The stimulation of PLA2/lysophospholipase activity by noradrenaline (NA) was prevented either by the alpha1-adrenergic antagonist prazosin or arachidonyl trifluoromethyl ketone, a selective inhibitor of the 85-110 kDa, sn-2-arachidonyl-specific cytosolic PLA2.	Norepinephrine	54-67	asparaginase	Rattus norvegicus	24-41
10578136-10	1999	4 ET-1 (1-3 nM) enhanced responses to noradrenaline (NA) (4 fold) but not to thromboxane A2-mimetic, whilst K+ (10-20 mM) sensitized vasa to both types of constrictor.	Norepinephrine	38-51	endothelin 1	Homo sapiens	2-6
10517903-5	1999	Somatostatin (10(-8) M) stimulated IgA secretion in the luminal effluent from 46.6 (14.3) to 79.3 (19.0) microg/5 min and increased the venous output to 148.3 (23.0)% (n=6) of basal output, whereas noradrenaline (10(-6) M) inhibited the secretion (to 49.2 (6.5)% of basal output, n=6).	Norepinephrine	198-211	CD79a molecule	Homo sapiens	35-38
10524943-8	1999	These contractions to noradrenaline and acetylcholine were competitively inhibited by prazosin (pK(B): 8.38 +/- 0.10) and atropine (pK(B): 8.52 +/- 0.43), respectively.	Norepinephrine	22-35	AKT serine/threonine kinase 1	Homo sapiens	96-100
10524943-8	1999	These contractions to noradrenaline and acetylcholine were competitively inhibited by prazosin (pK(B): 8.38 +/- 0.10) and atropine (pK(B): 8.52 +/- 0.43), respectively.	Norepinephrine	22-35	AKT serine/threonine kinase 1	Homo sapiens	132-136
10578236-1	1999	DOPA decarboxylase (DDC), also known as aromatic L-amino acid decarboxylase (AADC), is an enzyme involved in the synthesis of the important neurotransmitters dopamine, norepinephrine, and serotonin.	Norepinephrine	168-182	dopa decarboxylase	Homo sapiens	20-23
10578236-1	1999	DOPA decarboxylase (DDC), also known as aromatic L-amino acid decarboxylase (AADC), is an enzyme involved in the synthesis of the important neurotransmitters dopamine, norepinephrine, and serotonin.	Norepinephrine	168-182	dopa decarboxylase	Homo sapiens	40-75
10578236-1	1999	DOPA decarboxylase (DDC), also known as aromatic L-amino acid decarboxylase (AADC), is an enzyme involved in the synthesis of the important neurotransmitters dopamine, norepinephrine, and serotonin.	Norepinephrine	168-182	dopa decarboxylase	Homo sapiens	77-81
10549404-13	1999	Chronic ACE inhibition by 12 week oral imidapril administration (5-10 mg/day) significantly (P < 0.05) decreased baseline values of MSNA, which were accompanied by a significant (P < 0.05) increase in the reflex inhibition of MSNA, while plasma concentrations of noradrenaline were unaffected.	Norepinephrine	269-282	angiotensin I converting enzyme	Homo sapiens	8-11
10516637-14	1999	Western blot analysis showed an increase of inducible NO synthase (iNOS) in aortic rings exposed to noradrenaline or PGF2alpha.	Norepinephrine	100-113	nitric oxide synthase 2	Rattus norvegicus	44-65
10615401-0	1999	Angiotensin II modulates conducted vasoconstriction to norepinephrine and local electrical stimulation in rat mesenteric arterioles.	Norepinephrine	55-69	angiotensinogen	Rattus norvegicus	0-14
11270969-6	1999	The norepinephrine-activated PTK was inhibited by calphostin C and depletion of intra- and extra-cellular Ca2+.	Norepinephrine	4-18	EPH receptor A8	Homo sapiens	29-32
10522874-2	1999	BACKGROUND: AADC is a required enzyme in dopamine, norepinephrine, epinephrine, and serotonin biosynthesis.	Norepinephrine	51-65	dopa decarboxylase	Homo sapiens	12-16
10527641-3	1999	Acute stress was shown to induce a significant subsensitivity to norepinephrine only in vas deferens from adult rats with normal levels of androgens.	Norepinephrine	65-79	arginine vasopressin	Rattus norvegicus	88-91
10555559-1	1999	Noradrenaline-dependent brown adipose tissue (BAT) thermogenesis is activated by the cold and excess energy intake, largely depends on the activity of the uncoupling protein 1 (UCP1), and is mediated mainly through the beta3-adrenoceptor (beta3-AR).	Norepinephrine	0-13	uncoupling protein 1	Rattus norvegicus	177-181
10555559-5	1999	Treatment of mouse brown adipocytes in primary culture with noradrenaline also triggered a dose-dependent increase of the levels of UCP1 mRNA and UCP2 mRNA.	Norepinephrine	60-73	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	146-150
10499537-4	1999	Mice lacking dopamine beta-hydroxylase (Dbh-/-), the enzyme responsible for synthesizing norepinephrine and epinephrine from dopamine, were treated with leptin (20 microg/g body weight/day) for 3 days before they were euthanized.	Norepinephrine	89-103	dopamine beta hydroxylase	Mus musculus	40-47
10541052-9	1999	Our results suggest that: (1) total innervation of the thymus increases with age; (2) ANF do not change with age; (3) the content of noradrenaline in the thymus increases with age; and (4) NPY-like immunoreactive structures in the thymus decrease with age.	Norepinephrine	133-146	neuropeptide Y	Rattus norvegicus	189-192
10555559-1	1999	Noradrenaline-dependent brown adipose tissue (BAT) thermogenesis is activated by the cold and excess energy intake, largely depends on the activity of the uncoupling protein 1 (UCP1), and is mediated mainly through the beta3-adrenoceptor (beta3-AR).	Norepinephrine	0-13	uncoupling protein 1	Rattus norvegicus	155-175
10509627-3	1999	To evaluate the mechanism of vasodilation in sepsis, we used in vivo videomicroscopy to measure microvascular vasoconstrictive responses to topical suffusion of norepinephrine in mice made septic by cecal ligation and puncture, and contrasted the effects of topical superfusion of the nonselective NOS inhibitor N(G)-methyl-L-arginine (L-NMMA) and the selective inducible NOS (iNOS) inhibitor S-methyl-isothiourea (SMT).	Norepinephrine	161-175	nitric oxide synthase 2, inducible	Mus musculus	362-375
10509627-3	1999	To evaluate the mechanism of vasodilation in sepsis, we used in vivo videomicroscopy to measure microvascular vasoconstrictive responses to topical suffusion of norepinephrine in mice made septic by cecal ligation and puncture, and contrasted the effects of topical superfusion of the nonselective NOS inhibitor N(G)-methyl-L-arginine (L-NMMA) and the selective inducible NOS (iNOS) inhibitor S-methyl-isothiourea (SMT).	Norepinephrine	161-175	nitric oxide synthase 2, inducible	Mus musculus	377-381
10421711-0	1999	Discrete local application of corticotropin-releasing factor increases locus coeruleus discharge and extracellular norepinephrine in rat hippocampus.	Norepinephrine	115-129	corticotropin releasing hormone	Rattus norvegicus	30-60
10452985-0	1999	Norepinephrine-mediated inhibition of antitumor cytotoxic T lymphocyte generation involves a beta-adrenergic receptor mechanism and decreased TNF-alpha gene expression.	Norepinephrine	0-14	tumor necrosis factor	Mus musculus	142-151
10519972-3	1999	While agonists such as acetylcholine, noradrenaline, and KCl almost invariably give rise to conducted vasomotor responses others, such as sodium nitroprusside or vasopressin, do not.	Norepinephrine	38-51	arginine vasopressin	Homo sapiens	162-173
10484544-3	1999	METHODS AND RESULTS: Rats infused with norepinephrine or Ang II for 6 days developed similar hypertensive responses, but only Ang II-treated rats exhibited significant increases in aortic VCAM-1 protein and mRNA expression.	Norepinephrine	39-53	angiotensinogen	Rattus norvegicus	126-132
10559680-9	1999	The increased responsiveness to norepinephrine disappeared after preincubation of the vessels with a selective inhibitor of endothelin-1 type A receptors.	Norepinephrine	32-46	endothelin 1	Rattus norvegicus	124-136
10559680-11	1999	In conclusion, insulin at high, nonphysiological doses seems to induce an increase in the reactivity to norepinephrine in mesenteric small arteries of SHR, possibly mediated by a local production of endothelin-1.	Norepinephrine	104-118	endothelin 1	Rattus norvegicus	199-211
10580367-3	1999	administered interleukin-1beta (IL-1beta) (100 ng/animal) slightly, but significantly, elevated the plasma level of noradrenaline (NA), but not the level of adrenaline (Ad).	Norepinephrine	116-129	interleukin 1 beta	Rattus norvegicus	13-30
10468737-8	1999	CONCLUSION: Intra-abdominal placement of the testes with vas deferens ligation decreased the contractile response to noradrenaline in the ipsilateral vas deferens without altering the contractile response to EFS and high K+.	Norepinephrine	117-130	arginine vasopressin	Rattus norvegicus	57-60
10580367-3	1999	administered interleukin-1beta (IL-1beta) (100 ng/animal) slightly, but significantly, elevated the plasma level of noradrenaline (NA), but not the level of adrenaline (Ad).	Norepinephrine	116-129	interleukin 1 beta	Rattus norvegicus	32-40
10474050-0	1999	Mouse tumor necrosis factor-alpha increases brain tryptophan concentrations and norepinephrine metabolism while activating the HPA axis in mice.	Norepinephrine	80-94	tumor necrosis factor	Mus musculus	6-33
10469461-18	1999	These results together with the available literature show that NPY is a sympathetic transmitter, and its actions in the pineal gland are, therefore, associated with the well-documented roles of noradrenaline.	Norepinephrine	194-207	neuropeptide Y	Rattus norvegicus	63-66
10543432-2	1999	The aim of this study was to find out: (1) whether noradrenaline (NA) and the thromboxane A2 (TXA2)-mimetic U 46619-induced increases in the rate of protein synthesis may be also partly PTX-sensitive and/or mediated by ET-1, and (2) whether the growth-promoting effects of NA and U 46619 as well as ET-1 might involve activation of the same set of protein kinase C (PKC) isozymes.	Norepinephrine	51-64	endothelin 1	Rattus norvegicus	219-223
10543432-2	1999	The aim of this study was to find out: (1) whether noradrenaline (NA) and the thromboxane A2 (TXA2)-mimetic U 46619-induced increases in the rate of protein synthesis may be also partly PTX-sensitive and/or mediated by ET-1, and (2) whether the growth-promoting effects of NA and U 46619 as well as ET-1 might involve activation of the same set of protein kinase C (PKC) isozymes.	Norepinephrine	51-64	endothelin 1	Rattus norvegicus	299-303
10468737-8	1999	CONCLUSION: Intra-abdominal placement of the testes with vas deferens ligation decreased the contractile response to noradrenaline in the ipsilateral vas deferens without altering the contractile response to EFS and high K+.	Norepinephrine	117-130	arginine vasopressin	Rattus norvegicus	150-153
10427161-0	1999	Norepinephrine, tri-iodothyronine and insulin upregulate glyceraldehyde-3-phosphate dehydrogenase mRNA during Brown adipocyte differentiation.	Norepinephrine	0-14	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	57-97
10427161-3	1999	Insulin, tri-iodothyronine (T(3)) and norepinephrine, the main regulators of brown adipose tissue function, upregulated GAPDH mRNA levels, whereas retinoic acid inhibited them.	Norepinephrine	38-52	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	120-125
10427161-8	1999	Co-operation was elucidated between norepinephrine- and insulin-mediated induction of GAPDH mRNA levels.	Norepinephrine	36-50	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	86-91
10475560-2	1999	The study focused on the autonomic messengers neuropeptide Y (NPY), tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of noradrenaline (NA), and vasoactive intestinal polypeptide (VIP).	Norepinephrine	140-153	tyrosine hydroxylase	Homo sapiens	90-92
10512533-3	1999	In this cohort, AVP infusion (0.1 U/min) significantly increased mean arterial pressure and decreased norepinephrine requirements, allowing rapid discontinuation of norepinephrine infusions in 7 patients.	Norepinephrine	102-116	arginine vasopressin	Homo sapiens	16-19
10512533-3	1999	In this cohort, AVP infusion (0.1 U/min) significantly increased mean arterial pressure and decreased norepinephrine requirements, allowing rapid discontinuation of norepinephrine infusions in 7 patients.	Norepinephrine	165-179	arginine vasopressin	Homo sapiens	16-19
10451023-3	1999	IL-1beta was up-regulated in pineal cultures, after treatment with either norepinephrine (NE) or interferon (IFN)/lipopolysaccharide (LPS).	Norepinephrine	74-88	interleukin 1 beta	Rattus norvegicus	0-8
10494885-2	1999	The cannabinoid CB1 receptor agonists CP55,940, HU210 and anandamide inhibited evoked [3H]noradrenaline release.	Norepinephrine	90-103	cannabinoid receptor 1	Homo sapiens	16-19
10462192-8	1999	Mice in which cerebral norepinephrine was depleted with DSP-4 or 6-hydroxydopamine also displayed the usual hypophagia in response to mIL-1beta and LPS.	Norepinephrine	23-37	interleukin 1 beta	Mus musculus	134-143
10455273-7	1999	In conclusion, in mouse atria and spleen, angiotensin II and angiotensin III facilitate the action potential induced release of noradrenaline via a prejunctional AT1 receptor.	Norepinephrine	128-141	angiotensin II receptor, type 1a	Mus musculus	162-165
10478564-7	1999	In conclusion, it can be assumed that the powerful vasoconstrictions induced by 8-iso-prostaglandin E2 and 8-iso-prostaglandin F2alpha and their potentiating effects on vasoconstrictions induced by noradrenaline or angiotensin II might be of pathophysiological relevance in cardiovascular diseases.	Norepinephrine	198-211	angiotensinogen	Homo sapiens	215-229
10821639-4	1999	AADC neurons in the human ACC might transform L-DOPA to dopamine, droxidopa to noradrenaline, and/or 5-hydroxytryptophan to serotonin.	Norepinephrine	79-92	dopa decarboxylase	Homo sapiens	0-4
10424848-2	1999	The present study investigates the effects of BCAA on release of norepinephrine (NE) from isolated hippocampal brain slices.	Norepinephrine	65-79	AT-rich interaction domain 4B	Homo sapiens	46-50
10643604-0	1999	[Effect of cocaine on the contractile response to noradrenaline in the epididymal and prostatic regions of the vas deferens].	Norepinephrine	50-63	arginine vasopressin	Rattus norvegicus	111-114
10643604-1	1999	In the prostatic half of the rat vas deferens, the response to noradrenaline under the cocaine effect revealed a phasic and a tonic components, whereas in the epididymal portion of the vas deferens there only occurred the tonic component.	Norepinephrine	63-76	arginine vasopressin	Rattus norvegicus	33-36
10385678-1	1999	The recently identified transport proteins organic cation transporter 1 (OCT1), OCT2, and extraneuronal monoamine transporter (EMT) accept dopamine, noradrenaline, adrenaline, and 5-hydroxytryptamine as substrates and hence qualify as non-neuronal monoamine transporters.	Norepinephrine	149-162	solute carrier family 22 member 1	Homo sapiens	43-71
10381756-4	1999	Norepinephrine stimulated time- and concentration-dependent tyrosine phosphorylation of multiple proteins, including p52-, 75-, 85-, 120-, and 145-kDa proteins.	Norepinephrine	0-14	nuclear factor kappa B subunit 2	Homo sapiens	117-120
10385616-10	1999	Depletion of peripheral norepinephrine with 6-hydroxydopamine [100 mg/kg, intraperitoneal (i. p.)] inhibited the nicotine-induced plasma IL-6 levels by 57%, whereas central norepinephrine depletion with 6-hydroxydopamine (50 microgram/mouse, i.c.v.)	Norepinephrine	24-38	interleukin 6	Mus musculus	137-141
10385616-18	1999	increased IL-6 mRNA expression only in the liver and spleen, which was inhibited by peripheral norepinephrine depletion.	Norepinephrine	95-109	interleukin 6	Mus musculus	10-14
10377355-0	1999	Differential regulation of corticotropin-releasing hormone and vasopressin gene transcription in the hypothalamus by norepinephrine.	Norepinephrine	117-131	corticotropin releasing hormone	Rattus norvegicus	27-58
10377355-0	1999	Differential regulation of corticotropin-releasing hormone and vasopressin gene transcription in the hypothalamus by norepinephrine.	Norepinephrine	117-131	arginine vasopressin	Rattus norvegicus	63-74
10377355-5	1999	Norepinephrine (NE) is a well known neurotransmitter that regulates CRH neurons in the PVN.	Norepinephrine	0-14	corticotropin releasing hormone	Rattus norvegicus	68-71
10377371-1	1999	Consistent with the proposition that cytokines act as immunotransmitters between the immune system and the brain, systemic administration of the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha; 1.0-4.0 microg) induced mild illness in CD-1 mice, increased plasma corticosterone concentrations, and altered central norepinephrine, dopamine, and serotonin turnover.	Norepinephrine	329-343	tumor necrosis factor	Mus musculus	170-197
10385696-5	1999	Deletion of the alpha2A subtype led to an increase in sympathetic activity with resting tachycardia (knockout, 581 +/- 21 min-1; WT, 395 +/- 21 min-1), depletion of cardiac tissue norepinephrine concentration (knockout, 676 +/- 31 pg/mg protein; WT, 1178 +/- 98 pg/mg protein), and down-regulation of cardiac beta-ARs (Bmax: knockout, 23 +/- 1 fmol/mg protein; WT, 31 +/- 2 fmol/mg protein).	Norepinephrine	180-194	adrenergic receptor, alpha 2a	Mus musculus	16-23
10385696-11	1999	The results indicate that the alpha2A-AR is a major presynaptic receptor subtype regulating norepinephrine release from sympathetic nerves; however, the residual alpha2-mediated effect in the alpha2A-AR knockout mice suggests that a second alpha2 subtype (alpha2B or alpha2C) also functions as a presynaptic autoreceptor to inhibit transmitter release.	Norepinephrine	92-106	adrenergic receptor, alpha 2a	Mus musculus	30-40
10385678-1	1999	The recently identified transport proteins organic cation transporter 1 (OCT1), OCT2, and extraneuronal monoamine transporter (EMT) accept dopamine, noradrenaline, adrenaline, and 5-hydroxytryptamine as substrates and hence qualify as non-neuronal monoamine transporters.	Norepinephrine	149-162	solute carrier family 22 member 1	Homo sapiens	73-77
10361855-1	1999	Neuropeptide Y (NPY) and ATP are cotransmitters of norepinephrine (NE).	Norepinephrine	51-65	neuropeptide Y	Rattus norvegicus	0-14
10375645-3	1999	GAL has been shown to antagonize the postsynaptic actions of other cosecreted neurotransmitters including acetylcholine and norepinephrine; however, the ability of GAL to modulate the postsynaptic actions of VP has not been assessed.	Norepinephrine	124-138	galanin peptides	Mesocricetus auratus	0-3
10373426-2	1999	ASP and insulin inhibited basal and norepinephrine-induced FFA release by stimulating fractional FFA re-esterification (both to the same extent) and by inhibiting FFA produced during lipolysis (ASP to a lesser extent than insulin).	Norepinephrine	36-50	insulin	Homo sapiens	8-15
10373426-2	1999	ASP and insulin inhibited basal and norepinephrine-induced FFA release by stimulating fractional FFA re-esterification (both to the same extent) and by inhibiting FFA produced during lipolysis (ASP to a lesser extent than insulin).	Norepinephrine	36-50	insulin	Homo sapiens	222-229
10353260-1	1999	Since neurotensin is often co-stored with catecholamines and since it can excite the release of dopamine and norepinephrine, responses to this peptide might depend upon the activity of catecholaminergic systems.	Norepinephrine	109-123	neurotensin	Homo sapiens	6-17
10361855-1	1999	Neuropeptide Y (NPY) and ATP are cotransmitters of norepinephrine (NE).	Norepinephrine	51-65	neuropeptide Y	Rattus norvegicus	16-19
10323378-9	1999	During the stepwise hypoglycemic clamp, the counterregulatory increases in ACTH, cortisol, and norepinephrine were significantly blunted after the low insulin-ante-hypo (P < 0.01, P < 0.05, and P < 0.05, respectively) but not after the high insulin-ante-hypo (P = 0.12, P = 0.92, and P = 0.19, respectively) compared to that in the control group.	Norepinephrine	95-109	insulin	Homo sapiens	151-158
10336518-8	1999	In NRK-alpha2A cells, norepinephrine facilitated forskolin-stimulated cAMP accumulation, an effect not observed for dopamine.	Norepinephrine	22-36	adrenergic receptor, alpha 2a	Mus musculus	7-14
10336522-1	1999	Although abundant literature supports the notion that neuropeptide Y (NPY) synergizes in vivo and in vitro, the vasomotor activity elicited by norepinephrine (NE), the converse interaction (i.e., the adrenergic modulation of the NPY vasomotor response) has been less characterized.	Norepinephrine	143-157	neuropeptide Y	Rattus norvegicus	70-73
10338465-12	1999	This increase is mediated primarily by cardiac angiotensin II via AT1-subtype receptor and may be involved in post-MI ventricular fibrosis and in control of tissue norepinephrine concentration.	Norepinephrine	164-178	angiotensinogen	Rattus norvegicus	47-61
10338466-1	1999	BACKGROUND: Elevated circulating norepinephrine (NE) has been implicated in causing the profound beta-adrenergic receptor (betaAR) downregulation and receptor uncoupling that are characteristic of end-stage human dilated cardiomyopathy, a process mediated in part by increased levels of beta-adrenergic receptor kinase (betaARK1).	Norepinephrine	33-47	G protein-coupled receptor kinase 2	Homo sapiens	320-328
10235092-9	1999	In conclusion, our study demonstrates that insulin resistance is a common feature of CHF most likely due to elevated plasma norepinephrine and tumor necrosis factor-alpha concentrations, and that IMGU is an independent prognostic factor in CHF.	Norepinephrine	124-138	insulin	Homo sapiens	43-50
10215671-4	1999	alpha-Methylnoradrenaline dose-dependently increased heart rate, systolic blood pressure, cardiac output, blood glucose, serum insulin, free fatty acids, and gastrin, shortened the duration of heart rate-corrected electromechanical systole, and decreased diastolic blood pressure, total peripheral resistance, and plasma noradrenaline.	Norepinephrine	12-25	insulin	Homo sapiens	127-134
10215671-9	1999	administered alpha-methylnoradrenaline primarily acts on beta-adrenoceptors in the human cardiovascular and metabolic system, but an alpha2-adrenergic component of the response is detectable for changes of plasma noradrenaline, blood glucose, and serum insulin.	Norepinephrine	25-38	insulin	Homo sapiens	253-260
10466944-2	1999	Venlafaxine hydrochloride increased the response of rat vas deferens to noradrenaline but not to dopamine.	Norepinephrine	72-85	arginine vasopressin	Rattus norvegicus	56-59
10395064-0	1999	Induction of Egr-1 mRNA and protein by endothelin 1, angiotensin II and norepinephrine in neonatal cardiac myocytes.	Norepinephrine	72-86	early growth response 1	Rattus norvegicus	13-18
10395064-7	1999	Norepinephrine (NE, 2 microM), angiotensin II (AII, 0.1 microM), and endothelin 1 (E1, 0.1 microM) each induced the Egr-1 mRNA 6-8 fold and the Egr-1 protein 3-5 fold (n = 3, p < 0.01).	Norepinephrine	0-14	early growth response 1	Rattus norvegicus	116-130
10395064-7	1999	Norepinephrine (NE, 2 microM), angiotensin II (AII, 0.1 microM), and endothelin 1 (E1, 0.1 microM) each induced the Egr-1 mRNA 6-8 fold and the Egr-1 protein 3-5 fold (n = 3, p < 0.01).	Norepinephrine	0-14	early growth response 1	Rattus norvegicus	116-121
10361980-1	1999	Previous studies have shown that while vasopressin and angiotensin II are markedly more effective than norepinephrine and prostaglandin F2alpha in eliciting an acute elevation of inositol 1,4,5-trisphosphate (IP3), norepinephrine and prostaglandin F2alpha produce larger enhancement of DNA synthesis.	Norepinephrine	215-229	arginine vasopressin	Homo sapiens	39-50
10361980-1	1999	Previous studies have shown that while vasopressin and angiotensin II are markedly more effective than norepinephrine and prostaglandin F2alpha in eliciting an acute elevation of inositol 1,4,5-trisphosphate (IP3), norepinephrine and prostaglandin F2alpha produce larger enhancement of DNA synthesis.	Norepinephrine	215-229	angiotensinogen	Homo sapiens	55-69
10361980-4	1999	which remain elevated for at least 60 min., while norepinephrine and prostaglandin F2alpha elevate IP3 levels slightly and transiently For vasopressin the dose-effect curves for IP3 accumulation and stimulation of DNA synthesis were closely parallel, while this was not the case for angiotensin II, norepinephrine, or prostaglandin F2alpha.	Norepinephrine	50-64	arginine vasopressin	Homo sapiens	139-150
10361980-4	1999	which remain elevated for at least 60 min., while norepinephrine and prostaglandin F2alpha elevate IP3 levels slightly and transiently For vasopressin the dose-effect curves for IP3 accumulation and stimulation of DNA synthesis were closely parallel, while this was not the case for angiotensin II, norepinephrine, or prostaglandin F2alpha.	Norepinephrine	50-64	angiotensinogen	Homo sapiens	283-297
10361980-4	1999	which remain elevated for at least 60 min., while norepinephrine and prostaglandin F2alpha elevate IP3 levels slightly and transiently For vasopressin the dose-effect curves for IP3 accumulation and stimulation of DNA synthesis were closely parallel, while this was not the case for angiotensin II, norepinephrine, or prostaglandin F2alpha.	Norepinephrine	299-313	arginine vasopressin	Homo sapiens	139-150
10206236-2	1999	Involvement of central norepinephrine mechanisms is suggested by central norepinephrinic hyperactivity in patients with TS and by the therapeutic effects of the presynaptic alpha2-adrenergic agonist clonidine.	Norepinephrine	23-37	glycoprotein hormone subunit alpha 2	Homo sapiens	173-179
10192808-11	1999	The neurogenic relaxation is associated solely with activation of beta1 adrenoceptors by norepinephrine but is not mediated by NO or VIP.	Norepinephrine	89-103	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	66-71
10087056-0	1999	Role of phosphatidylinositol 3-kinase in angiotensin II regulation of norepinephrine neuromodulation in brain neurons of the spontaneously hypertensive rat.	Norepinephrine	70-84	angiotensinogen	Rattus norvegicus	41-55
10098870-0	1999	Differential involvement of central and peripheral norepinephrine in the central lipopolysaccharide-induced interleukin-6 responses in mice.	Norepinephrine	51-65	interleukin 6	Mus musculus	108-121
10098870-2	1999	Recently, it was reported that intraperitoneal administration of alpha-adrenoceptor antagonists inhibits centrally injected LPS-induced increases in plasma IL-6 levels, suggesting the involvement of the norepinephrine (NE) system in the central LPS-induced IL-6 response.	Norepinephrine	203-217	interleukin 6	Mus musculus	156-160
10098870-2	1999	Recently, it was reported that intraperitoneal administration of alpha-adrenoceptor antagonists inhibits centrally injected LPS-induced increases in plasma IL-6 levels, suggesting the involvement of the norepinephrine (NE) system in the central LPS-induced IL-6 response.	Norepinephrine	203-217	interleukin 6	Mus musculus	257-261
10194528-3	1999	Using intact capsular tissue it was found that VIP caused a dose-dependent increase in aldosterone secretion, with a concomitant increase in both adrenaline and noradrenaline release.	Norepinephrine	161-174	vasoactive intestinal peptide	Rattus norvegicus	47-50
10087056-1	1999	Chronic stimulation of norepinephrine (NE) neuromodulation by angiotensin II (Ang II) involves activation of the Ras-Raf-MAP kinase signal transduction pathway in Wistar Kyoto (WKY) rat brain neurons.	Norepinephrine	23-37	angiotensinogen	Rattus norvegicus	62-76
10087056-1	1999	Chronic stimulation of norepinephrine (NE) neuromodulation by angiotensin II (Ang II) involves activation of the Ras-Raf-MAP kinase signal transduction pathway in Wistar Kyoto (WKY) rat brain neurons.	Norepinephrine	23-37	angiotensinogen	Rattus norvegicus	78-84
10435048-5	1999	RESULTS: IL-1 beta increased basal NO-induced dilatation in the study vein, and this was sufficient to attenuate the constrictor response to exogenous noradrenaline or sympathetic stimulation.	Norepinephrine	151-164	interleukin 1 beta	Homo sapiens	9-18
10037744-1	1999	The synaptic action of norepinephrine is terminated by NaCl-dependent uptake into presynaptic noradrenergic nerve endings, mediated by the norepinephrine transporter (NET).	Norepinephrine	23-37	solute carrier family 6 member 2	Homo sapiens	139-165
10037744-1	1999	The synaptic action of norepinephrine is terminated by NaCl-dependent uptake into presynaptic noradrenergic nerve endings, mediated by the norepinephrine transporter (NET).	Norepinephrine	23-37	solute carrier family 6 member 2	Homo sapiens	167-170
10037744-2	1999	NET is expressed only in neuronal tissues that synthesize and secrete norepinephrine and in most cases is co-expressed with the norepinephrine-synthetic enzyme dopamine beta-hydroxylase (DBH).	Norepinephrine	70-84	solute carrier family 6 member 2	Homo sapiens	0-3
10037744-2	1999	NET is expressed only in neuronal tissues that synthesize and secrete norepinephrine and in most cases is co-expressed with the norepinephrine-synthetic enzyme dopamine beta-hydroxylase (DBH).	Norepinephrine	128-142	solute carrier family 6 member 2	Homo sapiens	0-3
10072003-3	1999	Vasopressin also potentiated the contraction elicited by 1.0 micromol/L norepinephrine (NE) in both the presence and absence of endothelium.	Norepinephrine	72-86	arginine vasopressin	Homo sapiens	0-11
10072003-8	1999	IMPLICATIONS: The results of our study suggest that, in addition to its direct vasoconstrictor effect, vasopressin strongly enhances the responses to norepinephrine through V1-receptor stimulation and that vasopressin could find a role in the management of endotoxin-induced vasodilation.	Norepinephrine	150-164	arginine vasopressin	Homo sapiens	103-114
10072003-8	1999	IMPLICATIONS: The results of our study suggest that, in addition to its direct vasoconstrictor effect, vasopressin strongly enhances the responses to norepinephrine through V1-receptor stimulation and that vasopressin could find a role in the management of endotoxin-induced vasodilation.	Norepinephrine	150-164	arginine vasopressin	Homo sapiens	206-217
10027827-0	1999	Bradykinin promotes ischemic norepinephrine release in guinea pig and human hearts.	Norepinephrine	29-43	kininogen 1	Homo sapiens	0-10
10027827-1	1999	We previously reported that bradykinin (BK; 1-1000 nM) facilitates norepinephrine (NE) release from cardiac sympathetic nerves.	Norepinephrine	67-81	kininogen 1	Homo sapiens	28-38
10027827-1	1999	We previously reported that bradykinin (BK; 1-1000 nM) facilitates norepinephrine (NE) release from cardiac sympathetic nerves.	Norepinephrine	67-81	kininogen 1	Homo sapiens	40-42
10344632-2	1999	In the low micromolar range, orphenadrine enhanced electrically-evoked and exogenous noradrenaline contractile responses in the epididymal portion of rat vas deferens.	Norepinephrine	85-98	arginine vasopressin	Rattus norvegicus	154-157
10050974-1	1999	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of dopamine and noradrenaline.	Norepinephrine	87-100	tyrosine hydroxylase	Homo sapiens	0-20
9989970-7	1999	In parallel studies, endothelin-1 suppressed the development of reperfusion arrhythmias initiated by either thrombin (ventricular fibrillation, 75% to 39%, n=16 to 18) or norepinephrine (83% to 8%, n=12 to 22) (P<0.01 in both cases).	Norepinephrine	171-185	endothelin 1	Rattus norvegicus	21-33
9927320-8	1999	Because catecholamines increase intracellular cAMP levels, we investigated the effects of dopamine, epinephrine, and norepinephrine on IL-6 release.	Norepinephrine	117-131	interleukin 6	Rattus norvegicus	135-139
10079965-2	1999	Catecholamine (dopamine, norepinephrine, and epinephrine) biosynthesis is regulated by tyrosine hydroxylase (TH).	Norepinephrine	25-39	tyrosine hydroxylase	Homo sapiens	87-107
10079965-2	1999	Catecholamine (dopamine, norepinephrine, and epinephrine) biosynthesis is regulated by tyrosine hydroxylase (TH).	Norepinephrine	25-39	tyrosine hydroxylase	Homo sapiens	109-111
9927621-2	1999	In PC12 cells stably transfected with the human alpha-1A AR, norepinephrine (NE) strongly activated both extracellular signal regulated kinases (ERKs) and c-jun-NH2-terminal kinases (JNK).	Norepinephrine	61-75	mitogen-activated protein kinase 8	Homo sapiens	155-181
9927320-14	1999	The coincubation of LPC with norepinephrine provoked a synergistic release in IL-6 comparable with that obtained with IL-1beta and norepinephrine.	Norepinephrine	29-43	interleukin 6	Rattus norvegicus	78-82
10068164-4	1999	In sympathetic neurons, NPY is colocalized and coreleased with norepinephrine (NE) at peripheral sites of action.	Norepinephrine	63-77	neuropeptide Y	Rattus norvegicus	24-27
9927621-2	1999	In PC12 cells stably transfected with the human alpha-1A AR, norepinephrine (NE) strongly activated both extracellular signal regulated kinases (ERKs) and c-jun-NH2-terminal kinases (JNK).	Norepinephrine	61-75	mitogen-activated protein kinase 8	Homo sapiens	183-186
10226765-5	1999	On day 20 ex vivo aortic ring relaxation was produced by ET-1 in vessels previously precontracted with norepinephrine only when endothelium was present.	Norepinephrine	103-117	endothelin 1	Rattus norvegicus	57-61
9917358-0	1999	The neurotransmitter noradrenaline drives noggin-expressing ectoderm cells to activate N-tubulin and become neurons.	Norepinephrine	21-34	noggin S homeolog	Xenopus laevis	42-48
9917358-6	1999	By contrast, 10(-8) M noradrenaline activated N-tubulin in ectoderm caps expressing the neural inducing molecule noggin by the time intact siblings had become mid-neurulae.	Norepinephrine	22-35	noggin S homeolog	Xenopus laevis	113-119
9917358-13	1999	We propose that noradrenaline is an important endogenous modulator of neuronal fate, driving noggin-expressing cells to become neurons by binding to alpha-adrenergic receptors and activating a cascade that culminates in the expression of the neuronal markers N-tubulin and 3A10.	Norepinephrine	16-29	noggin S homeolog	Xenopus laevis	93-99
9915270-9	1999	In addition, sequential measurements of neurohormonal mediator levels in patients receiving calcitriol showed that plasma renin (18.5 +/- 12.7 v 12.3 +/- 11.0 pg/mL; P = 0.007), angiotensin II (AT II; 79.7 +/- 48.6 v 47.2 +/- 45.7 pg/mL; P = 0.001), and atrial natriuretic peptide (ANP; 16.6 +/- 9.7 v 12.2 +/- 4.4 pg/mL; P = 0.03) levels significantly decreased, whereas antidiuretic hormone (ADH), epinephrine, and norepinephrine levels did not change significantly.	Norepinephrine	417-431	renin	Homo sapiens	122-127
10810506-1	1999	NPY is considered to play an important role in pineal function, because it is co-stored with the dominant pineal transmitter noradrenaline.	Norepinephrine	125-138	neuropeptide Y	Rattus norvegicus	0-3
10810506-8	1999	These results together with the available literature imply that NPY under certain conditions is co-released with noradrenaline and exerts its actions either presynaptically or on the pinealocyte through a Y1 receptor.	Norepinephrine	113-126	neuropeptide Y	Rattus norvegicus	64-67
10810506-9	1999	The available data indicate that NPY has no effect alone, but acts in concert with noradrenaline.	Norepinephrine	83-96	neuropeptide Y	Rattus norvegicus	33-36
9886965-12	1999	In these T3-treated animals, the interscapular BAT thermal response to norepinephrine infusion also correlated positively with T3 dose and UCP content.	Norepinephrine	71-85	uncoupling protein 1	Rattus norvegicus	139-142
10374901-1	1999	The high level transection of the spinal cord (C-7) provokes a sustained increase of rat liver catecholamines: biphasic increase in norepinephrine level 1 hour and 24 hour after the operation and 7-fold increase of dopamine content 4 hour after the chordotomy.	Norepinephrine	132-146	complement C7	Rattus norvegicus	47-50
10392347-6	1999	We found similar responses of growth hormone, cortisol, epinephrine, norepinephrine and dopamine to both porcine insulin- and human insulin- induced hypoglycemia.	Norepinephrine	69-83	insulin	Homo sapiens	113-120
10366021-11	1999	Expression of alpha1D messenger RNA in distinct subsets of cells synthesizing corticotropin-releasing hormone may also help to clarify contradictory and inconsistent observations in the literature regarding the role of norepinephrine in the stress response, and may account for a presumed stressor-specific role for norepinephrine in activation of the hypothalamic-pituitary-adrenal axis.	Norepinephrine	219-233	corticotropin releasing hormone	Rattus norvegicus	78-109
10622284-0	1999	Participation of cAMP in the facilitatory action of beta,gamma-methylene ATP on the noradrenaline release from rabbit ear artery.	Norepinephrine	84-97	solute carrier family 45, member 2	Mus musculus	73-76
10622284-1	1999	beta, gamma-Methylene ATP (betagamma-mATP) significantly facilitated the electrically (4 Hz) evoked release of noradrenaline (NA) from the rabbit ear artery by activation of prejunctional purinoceptors on the sympathetic nerve terminals.	Norepinephrine	111-124	solute carrier family 45, member 2	Mus musculus	22-25
10622284-1	1999	beta, gamma-Methylene ATP (betagamma-mATP) significantly facilitated the electrically (4 Hz) evoked release of noradrenaline (NA) from the rabbit ear artery by activation of prejunctional purinoceptors on the sympathetic nerve terminals.	Norepinephrine	111-124	solute carrier family 45, member 2	Mus musculus	37-41
9876234-3	1999	Noradrenaline and ATP stimulated IL-6 production in the culture supernatants 14- and 23-fold over basal values after 24 h. Co-stimulation with noradrenaline and ATP yielded an additive effect.	Norepinephrine	0-13	interleukin 6	Rattus norvegicus	33-37
9876234-3	1999	Noradrenaline and ATP stimulated IL-6 production in the culture supernatants 14- and 23-fold over basal values after 24 h. Co-stimulation with noradrenaline and ATP yielded an additive effect.	Norepinephrine	143-156	interleukin 6	Rattus norvegicus	33-37
10591051-3	1999	Selegiline pretreatment prevented the depletion of noradrenaline (NA) induced by DSP-4 in the rat hippocampus.	Norepinephrine	51-64	dual specificity phosphatase 26	Homo sapiens	81-86
10366021-11	1999	Expression of alpha1D messenger RNA in distinct subsets of cells synthesizing corticotropin-releasing hormone may also help to clarify contradictory and inconsistent observations in the literature regarding the role of norepinephrine in the stress response, and may account for a presumed stressor-specific role for norepinephrine in activation of the hypothalamic-pituitary-adrenal axis.	Norepinephrine	316-330	corticotropin releasing hormone	Rattus norvegicus	78-109
10069701-1	1998	This study was designed to determine the role of endogenous nitric oxide (NO) in the corticotropin-releasing hormone (CRH)-induced ACTH and corticosterone secretion, as well as possible involvement of hypothalamic dopamine and noradrenaline in that secretion in conscious rats.	Norepinephrine	227-240	corticotropin releasing hormone	Rattus norvegicus	118-121
9824716-5	1998	Following coinjection of either GIRK1-2 or GIRK1-4 cDNA, application of noradrenaline (NA) produced large inwardly rectifying K+ currents.	Norepinephrine	72-85	potassium inwardly-rectifying channel, subfamily J, member 3	Rattus norvegicus	32-39
9824716-5	1998	Following coinjection of either GIRK1-2 or GIRK1-4 cDNA, application of noradrenaline (NA) produced large inwardly rectifying K+ currents.	Norepinephrine	72-85	potassium inwardly-rectifying channel, subfamily J, member 3	Rattus norvegicus	32-37
9928073-1	1998	(1) A beta peptides potentiate vasoconstriction, caused by norepinephrine, and possibly other endogenous vasoconstrictors.	Norepinephrine	59-73	amyloid beta precursor protein	Homo sapiens	4-10
10052665-9	1998	Plasma noradrenaline sulphate (NA-S) increased with exercise intensity showing higher mean increments after the first set of HLX compared to LHX [1.83 (SEM 0.42) v.s.	Norepinephrine	31-35	H2.0 like homeobox	Homo sapiens	125-128
10052667-3	1998	The noradrenaline infusion increased the unstimulated, the interleukin-2 and interferon-alpha stimulated NK cell activity, and the percentage of CD16+ cells.	Norepinephrine	4-17	interleukin 2	Homo sapiens	59-72
9822156-2	1998	Introduction of the TH transgene directed by the dopamine beta-hydroxylase gene promoter into TH knockout mice restored noradrenaline and adrenaline synthesis, preventing perinatal lethality and cardiac dysfunction in the knockout mice.	Norepinephrine	120-133	dopamine beta hydroxylase	Mus musculus	49-74
9832689-12	1998	Retrospective analysis found 40 patients with postbypass vasodilatory shock who received low-dose arginine vasopressin infusions, resulting in increased mean arterial pressure and decreased norepinephrine requirements.	Norepinephrine	190-204	arginine vasopressin	Homo sapiens	107-118
9804770-1	1998	Erk1/2 promotes norepinephrine-dependent cell survival.	Norepinephrine	16-30	mitogen-activated protein kinase 3	Homo sapiens	0-6
9804770-5	1998	In primary cultures of brown adipose tissue, norepinephrine (NE) stimulated both the phosphorylation and the activity of Erk1/2 via the Erk kinase MEK, and protected the cells form apoptosis.	Norepinephrine	45-59	mitogen-activated protein kinase 3	Homo sapiens	121-127
9804770-5	1998	In primary cultures of brown adipose tissue, norepinephrine (NE) stimulated both the phosphorylation and the activity of Erk1/2 via the Erk kinase MEK, and protected the cells form apoptosis.	Norepinephrine	45-59	mitogen-activated protein kinase kinase 7	Homo sapiens	147-150
9794415-3	1998	Incubation of murine thymocytes or S49 mouse thymoma cells with dibutyryl-cAMP, 8-bromo-cAMP, cholera toxin, norepinephrine, or isoproterenol caused time- and concentration-dependent decreases in levels of Thy-1 mRNA assayed by Northern hybridization or T2 nuclease protection.	Norepinephrine	109-123	thymus cell antigen 1, theta	Mus musculus	206-211
9795140-2	1998	Specific transporters have been cloned for both dopamine (DAT) and noradrenaline (NAT) in the rat.	Norepinephrine	67-80	N-acetyltransferase 1	Rattus norvegicus	82-85
9794415-5	1998	Norepinephrine-mediated decreases in Thy-1 mRNA levels were prevented by the beta-adrenergic receptor antagonist propranolol (10 microM).	Norepinephrine	0-14	thymus cell antigen 1, theta	Mus musculus	37-42
9794415-6	1998	Dibutyryl-cAMP and norepinephrine decreased the apparent half-life of S49 cell Thy-1 mRNA from >>6 h to 2 to 3 h, whereas nuclear run-on assays showed no cAMP or norepinephrine effect on de novo transcription of the Thy-1 gene.	Norepinephrine	19-33	thymus cell antigen 1, theta	Mus musculus	79-84
9798905-2	1998	In noradrenergic neurons, dopamine beta-hydroxylase (DBH) is a hallmark protein and catalyzes the conversion of dopamine to noradrenaline.	Norepinephrine	124-137	dopamine beta hydroxylase	Mus musculus	26-51
9794415-6	1998	Dibutyryl-cAMP and norepinephrine decreased the apparent half-life of S49 cell Thy-1 mRNA from >>6 h to 2 to 3 h, whereas nuclear run-on assays showed no cAMP or norepinephrine effect on de novo transcription of the Thy-1 gene.	Norepinephrine	19-33	thymus cell antigen 1, theta	Mus musculus	222-227
9794415-6	1998	Dibutyryl-cAMP and norepinephrine decreased the apparent half-life of S49 cell Thy-1 mRNA from >>6 h to 2 to 3 h, whereas nuclear run-on assays showed no cAMP or norepinephrine effect on de novo transcription of the Thy-1 gene.	Norepinephrine	168-182	thymus cell antigen 1, theta	Mus musculus	79-84
9794415-8	1998	These observations show that exogenous cAMP and norepinephrine can induce decreases in steady state Thy-1 mRNA levels in T-lineage cells through posttranscriptional destabilization of Thy-1 mRNA, associated with protein kinase A-mediated protein phosphorylation.	Norepinephrine	48-62	thymus cell antigen 1, theta	Mus musculus	100-105
9794415-8	1998	These observations show that exogenous cAMP and norepinephrine can induce decreases in steady state Thy-1 mRNA levels in T-lineage cells through posttranscriptional destabilization of Thy-1 mRNA, associated with protein kinase A-mediated protein phosphorylation.	Norepinephrine	48-62	thymus cell antigen 1, theta	Mus musculus	184-189
9798905-2	1998	In noradrenergic neurons, dopamine beta-hydroxylase (DBH) is a hallmark protein and catalyzes the conversion of dopamine to noradrenaline.	Norepinephrine	124-137	dopamine beta hydroxylase	Mus musculus	53-56
9763638-16	1998	Forskolin, an activator of endogenous adenylate cyclase, and 3-isobutyl-1-methylxanthine, a phosphodiesterase inhibitor, mimicked the ability of noradrenaline to increase both steady-state pHi and rates of pHi recovery from imposed acid loads, as did Sp-cAMPS, a selective activator of cAMP-dependent protein kinase.	Norepinephrine	145-158	calmodulin 2, pseudogene 1	Rattus norvegicus	254-259
10214982-0	1998	Olfactory bulb norepinephrine depletion abolishes vasopressin and oxytocin preservation of social recognition responses in rats.	Norepinephrine	15-29	arginine vasopressin	Rattus norvegicus	50-61
9763638-14	1998	However, the effects of noradrenaline were blocked by pre-treatment with the adenylate cyclase inhibitor 2",5"-dideoxyadenosine and the cAMP-dependent protein kinase inhibitors Rp-adenosine-3",5"-cyclic monophosphorothioate (sodium salt; Rp-cAMPS) and N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulphonamide (H-89).	Norepinephrine	24-37	calmodulin 2, pseudogene 1	Rattus norvegicus	241-246
10214982-0	1998	Olfactory bulb norepinephrine depletion abolishes vasopressin and oxytocin preservation of social recognition responses in rats.	Norepinephrine	15-29	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	66-74
9865861-2	1998	infusions of corticotropin-releasing factor (CRF) activate locus coeruleus (LC) noradrenergic neurons and increase the metabolism and extracellular concentrations of norepinephrine (NE) in several brain regions, suggesting increased release.	Norepinephrine	166-180	corticotropin releasing hormone	Rattus norvegicus	13-43
9817439-0	1998	Effect of IL-1alpha on the release of norepinephrine in rat hypothalamus.	Norepinephrine	38-52	interleukin 1 alpha	Rattus norvegicus	10-19
9789694-1	1998	BACKGROUND AND HYPOTHESIS: In vitro studies have shown that atrial natriuretic peptide (ANP) causes relaxation of preconstricted blood vessel strips and inhibits the contraction of isolated vessels in response to norepinephrine and angiotensin II.	Norepinephrine	213-227	natriuretic peptide A	Homo sapiens	60-86
9789694-1	1998	BACKGROUND AND HYPOTHESIS: In vitro studies have shown that atrial natriuretic peptide (ANP) causes relaxation of preconstricted blood vessel strips and inhibits the contraction of isolated vessels in response to norepinephrine and angiotensin II.	Norepinephrine	213-227	natriuretic peptide A	Homo sapiens	88-91
9831230-0	1998	Effect of calcium antagonists on the response to noradrenaline in the whole and bisected rat vas deferens.	Norepinephrine	49-62	arginine vasopressin	Rattus norvegicus	93-96
9831230-2	1998	The present study was carried out to look at the effect of different calcium antagonists on the response to noradrenaline in the whole and bisected rat vas deferens considering that the response consisted of three components (I) the phasic response (II) the tonic response and (III) the spikes (rhythmic contractions).	Norepinephrine	108-121	arginine vasopressin	Rattus norvegicus	152-155
9769330-5	1998	The negative inotropic effects of a beta3-adrenoceptor agonist, BRL 37344, and also of norepinephrine in the presence of alpha- and beta1-2-blockade were inhibited both by a nonspecific blocker of NO, methylene blue, and two NO synthase (NOS) inhibitors, L-N-monomethyl-arginine and L-nitroarginine-methyl ester.	Norepinephrine	87-101	nitric oxide synthase 2	Homo sapiens	225-236
9802414-2	1998	In rat aortic A10 cell line, NPY"s potency was greater than that of norepinephrine, and efficacy similar to that of platelet-derived growth factor, but less than that of the full serum, in stimulating cell proliferation; this effect was optimal in cell 60-80% cell density.	Norepinephrine	68-82	neuropeptide Y	Rattus norvegicus	29-32
9848093-4	1998	We now report that catecholamines (norepinephrine, epinephrine, and dopamine) increase the vulnerability of cultured hippocampal neurons to A beta toxicity.	Norepinephrine	35-49	amyloid beta precursor protein	Homo sapiens	140-146
9716701-3	1998	In vitro experiments showed that steroid hormones, beta-estradiol, estrone and progesterone, can reduce norepinephrine-induced UCP1 synthesis in brown adipocytes differentiated in primary culture.	Norepinephrine	104-118	uncoupling protein 1	Rattus norvegicus	127-131
9752889-7	1998	These results indicate that dietary sodium restriction leads to a deterioration of insulin sensitivity when plasma norepinephrine levels increase, and suggest that moderate dietary sodium reduction may lower blood pressure without a distinct adverse effect on glucose metabolism in subjects with primary hypertension.	Norepinephrine	115-129	insulin	Homo sapiens	83-90
9740613-1	1998	Angiotensin II (Ang II), via its interaction with the angiotensin type 1 (AT1) receptor subtype, causes enhanced stimulation of norepinephrine (NE) neuromodulation.	Norepinephrine	128-142	angiotensinogen	Rattus norvegicus	0-22
9724316-3	1998	We hypothesize that in vivo pretreatment with AS oligonucleotide targeted to iNOS mRNA can prevent LPS-induced hyporeactivity to norepinephrine (NE).	Norepinephrine	129-143	nitric oxide synthase 2	Rattus norvegicus	77-81
9728078-0	1998	IL-1beta increases norepinephrine level in rat frontal cortex: involvement of prostanoids, NO, and glutamate.	Norepinephrine	19-33	interleukin 1 beta	Rattus norvegicus	0-8
9728078-2	1998	A local injection of IL-1beta (3 and 10 ng) induced an elevation of norepinephrine (NE) concentration in the medial prefrontal cortex (mPFC).	Norepinephrine	68-82	interleukin 1 beta	Rattus norvegicus	21-29
9724817-3	1998	We now show that the primate ovary expresses both the genes encoding TH and dopamine beta-hydroxylase (DBH), the key enzymes in norepinephrine (NE) biosynthesis.	Norepinephrine	128-142	tyrosine hydroxylase	Homo sapiens	69-71
9745422-9	1998	Urinary levels of norepinephrine decreased significantly (P < 0.05) during IGF-I infusion.	Norepinephrine	18-32	insulin like growth factor 1	Homo sapiens	78-83
12016870-2	1998	Vasodilative activity screening in vitro has shown that most of the compounds possess various activities, among which compound H1, H11, H17, E1, E3 demonstrated a superior pharmacological profile to the lead compound when inhibiting effect on the noradrenaline (10(-7) mol.L-1) induced contraction of rat aortic strip was chosen as the evaluation criterion, while H7,15, E7 exerted significant inhibiting action toward 85.7 mmol.L-1 KCl induced contraction of rat aortic strip.	Norepinephrine	247-260	carboxylesterase 1C	Rattus norvegicus	127-147
9732394-4	1998	Vasopressin (10(-11) and 3 x 10(-11) M) caused concentration-dependent potentiation of the contractions elicited by electrical stimulation (15 V, 0.5-2 Hz, 0.2 msec duration for 15 sec) and produced leftward shifts of the concentration-response curve for norepinephrine.	Norepinephrine	255-269	arginine vasopressin	Homo sapiens	0-11
9732394-8	1998	In addition, vasopressin strongly potentiates the contractions to norepinephrine and stimulation of perivascular adrenergic nerves.	Norepinephrine	66-80	arginine vasopressin	Homo sapiens	13-24
9619301-4	1998	We present here the first direct evidence that noradrenaline elicits long-lasting NO production in C6 cells pretreated with lipopolysaccharide and interferon-gamma, an effect blocked by NG-monomethyl-L-arginine, a NO synthase inhibitor.	Norepinephrine	47-60	interferon gamma	Homo sapiens	147-163
9715790-8	1998	Intranasal ANG II also counteracted the decrease in norepinephrine levels observed after intravenous administration of ANG II.	Norepinephrine	52-66	angiotensinogen	Homo sapiens	11-17
9715790-8	1998	Intranasal ANG II also counteracted the decrease in norepinephrine levels observed after intravenous administration of ANG II.	Norepinephrine	52-66	angiotensinogen	Homo sapiens	119-125
9754937-2	1998	Vasopressin (3 x 10(-9)-3 x 10(-8) M) enhanced the phasic contractions elicited by electrical field stimulation and noradrenaline.	Norepinephrine	116-129	arginine vasopressin	Homo sapiens	0-11
9688715-1	1998	Endothelin-1 (ET-1) is a potent vasoconstrictor peptide, which also potentiates contractions to norepinephrine in human internal mammary and coronary vessels.	Norepinephrine	96-110	endothelin 1	Homo sapiens	0-12
9688715-1	1998	Endothelin-1 (ET-1) is a potent vasoconstrictor peptide, which also potentiates contractions to norepinephrine in human internal mammary and coronary vessels.	Norepinephrine	96-110	endothelin 1	Homo sapiens	14-18
9688715-8	1998	Therefore, the present study provides a possibility that the exercise-induced increase in production of ET-1 in the kidneys causes vasoconstriction and hence decreases blood flow in the kidneys through its direct vasoconstrictive action and/or its indirect effect of enhancing vasoconstrictions to norepinephrine.	Norepinephrine	298-312	endothelin 1	Rattus norvegicus	104-108
9711055-5	1998	Heart failure results in activation of the renin-angiotensin system as a compensatory mechanism with elevation of circulating angiotensin II, norepinephrine and vasopressin.	Norepinephrine	142-156	renin	Homo sapiens	43-48
9798735-8	1998	VIP has an additive effect at a lower (100 nM) concentration combined with norepinephrine (NE).	Norepinephrine	75-89	vasoactive intestinal peptide	Rattus norvegicus	0-3
9794720-1	1998	OBJECTIVE: To test the hypothesis that insulin differently modifies vasoconstriction and recovery from vasoconstriction induced by endogenously released versus circulating norepinephrine, and to investigate the time-dependency of its effect METHODS: Healthy male subjects were studied.	Norepinephrine	172-186	insulin	Homo sapiens	39-46
9794720-2	1998	Norepinephrine was infused for 10 min into the brachial artery with 40 min pauses in between, three times with vehicle and three times during concurrent intra-arterial infusion of 0.1 mU/kg per min insulin, inducing locally high, above physiologic, concentrations of insulin.	Norepinephrine	0-14	insulin	Homo sapiens	198-205
9794720-2	1998	Norepinephrine was infused for 10 min into the brachial artery with 40 min pauses in between, three times with vehicle and three times during concurrent intra-arterial infusion of 0.1 mU/kg per min insulin, inducing locally high, above physiologic, concentrations of insulin.	Norepinephrine	0-14	insulin	Homo sapiens	267-274
9794720-7	1998	Administration of norepinephrine decreased the FBFi: FBFc ratio by 29+/-7% (mean +/- SEM) before and 45+/-4% during infusion of insulin (P < 0.01).	Norepinephrine	18-32	insulin	Homo sapiens	128-135
9794720-8	1998	After cessation of the norepinephrine infusions blood flow rapidly recovered, which even resulted in an overshoot vasodilatation during infusion of insulin.	Norepinephrine	23-37	insulin	Homo sapiens	148-155
9794720-12	1998	Infusion of insulin significantly reduced the apparent concentrations of norepinephrine and tyramine at which half maximal effect occurs (EC50).	Norepinephrine	73-87	insulin	Homo sapiens	12-19
9794720-14	1998	CONCLUSIONS: Vasoconstriction induced by exogenous or endogenous norepinephrine is augmented by a high concentration of insulin.	Norepinephrine	65-79	insulin	Homo sapiens	120-127
9718981-0	1998	Acute effects of interleukin-1 beta on noradrenaline release from the human neuroblastoma cell line SH-SY5Y.	Norepinephrine	39-52	interleukin 1 beta	Homo sapiens	17-35
9667295-7	1998	A second series of measurements were performed after norepinephrine or phenylephrine had increased mean arterial blood pressure by about 20% (test 1).	Norepinephrine	53-67	serine protease 21	Homo sapiens	142-148
9697858-4	1998	Specific CAPS antibodies inhibit Ca2+-activated norepinephrine release from lysed synaptosomes that contain membrane-associated CAPS, indicating that membrane-bound CAPS is essential for neural DCV exocytosis.	Norepinephrine	48-62	calcyphosine	Homo sapiens	9-13
9645680-7	1998	Finally, the central injection of the beta-adrenergic agonist isoproterenol, as well as that of norepinephrine, mimicked the ability of icv IL-1beta to blunt testicular secretory activity and produced a marked (P < 0.01) decrease in the response to hCG within 5 min of their administration.	Norepinephrine	96-110	interleukin 1 beta	Homo sapiens	140-148
9658406-0	1998	Dominant negative regulation by c-Jun of transcription of the uncoupling protein-1 gene through a proximal cAMP-regulatory element: a mechanism for repressing basal and norepinephrine-induced expression of the gene before brown adipocyte differentiation.	Norepinephrine	169-183	uncoupling protein 1	Rattus norvegicus	62-82
9658406-1	1998	The brown fat uncoupling protein-1 (ucp-1) gene is regulated by the sympathetic nervous system, and its transcription is stimulated by norepinephrine, mainly through cAMP-mediated pathways.	Norepinephrine	135-149	uncoupling protein 1	Rattus norvegicus	14-41
9697858-4	1998	Specific CAPS antibodies inhibit Ca2+-activated norepinephrine release from lysed synaptosomes that contain membrane-associated CAPS, indicating that membrane-bound CAPS is essential for neural DCV exocytosis.	Norepinephrine	48-62	calcyphosine	Homo sapiens	128-132
9697858-4	1998	Specific CAPS antibodies inhibit Ca2+-activated norepinephrine release from lysed synaptosomes that contain membrane-associated CAPS, indicating that membrane-bound CAPS is essential for neural DCV exocytosis.	Norepinephrine	48-62	calcyphosine	Homo sapiens	128-132
9721022-2	1998	The functional activity of these ligands on the histamine H3 receptor-mediated inhibition of neurogenic contraction of the guinea-pig jejunum and histamine H3 receptor-mediated inhibition of norepinephrine release from guinea-pig heart synaptosomes were investigated.	Norepinephrine	191-205	histamine H3 receptor	Cavia porcellus	146-167
9721022-4	1998	In addition, GT-2227 and GT-2331 antagonized the inhibition of norepinephrine release in cardiac synaptosomes by GT-2203 ((1R,2R)-trans-2-(1H-imidazol-4-yl)cyclopropylamine), a histamine H3 receptor agonist.	Norepinephrine	63-77	histamine H3 receptor	Cavia porcellus	177-198
9632371-8	1998	Hydroxylation of 8 at the 2"-position gave 14 which enhanced not only the binding potency at the DAT by another 2-fold but also the selectivity at the DAT over the norepinephrine and serotonin transporters.	Norepinephrine	164-178	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	97-100
9676821-7	1998	The results suggest that SERT and NET genotypes may participate differentially in the regulation of the norepinephrine turnover rate under presumed steady-state conditions in the central nervous system.	Norepinephrine	104-118	solute carrier family 6 member 4	Homo sapiens	25-29
9696062-2	1998	Neuropeptide Y (NPY) is found in cell bodies of neurons in the brain and co-localized with noradrenaline (NA) in sympathetic nerves as well as with NA and adrenaline (A) in the adrenal chromaffin cells.	Norepinephrine	91-104	neuropeptide Y	Rattus norvegicus	0-14
9696062-2	1998	Neuropeptide Y (NPY) is found in cell bodies of neurons in the brain and co-localized with noradrenaline (NA) in sympathetic nerves as well as with NA and adrenaline (A) in the adrenal chromaffin cells.	Norepinephrine	91-104	neuropeptide Y	Rattus norvegicus	16-19
9663564-5	1998	However, co-stimulation with adrenaline, noradrenaline, or the beta-adrenoceptor agonist isoproterenol (isoprenaline) had an additive (TNF-alpha) or synergistic (LPS) effect on IL-6 release.	Norepinephrine	41-54	tumor necrosis factor	Rattus norvegicus	135-144
9663564-5	1998	However, co-stimulation with adrenaline, noradrenaline, or the beta-adrenoceptor agonist isoproterenol (isoprenaline) had an additive (TNF-alpha) or synergistic (LPS) effect on IL-6 release.	Norepinephrine	41-54	interleukin 6	Rattus norvegicus	177-181
9669316-7	1998	Cross-correlation between norepinephrine-evoked Ca2+ wave amplitude and calreticulin distribution indicated a close spatial relationship between this Ca2+-binding protein and sites of regenerative wave amplification.	Norepinephrine	26-40	calreticulin	Homo sapiens	72-84
9676821-7	1998	The results suggest that SERT and NET genotypes may participate differentially in the regulation of the norepinephrine turnover rate under presumed steady-state conditions in the central nervous system.	Norepinephrine	104-118	solute carrier family 6 member 2	Homo sapiens	34-37
9696413-0	1998	Changes in electrophysiological properties and noradrenaline response in vas deferens of diabetic rats.	Norepinephrine	47-60	arginine vasopressin	Rattus norvegicus	73-76
9696413-5	1998	The dose-response curve for the contractile response of the vas deferens to noradrenaline was significantly shifted to the right and the apparent affinity (pD2 value) was significantly decreased in streptozotocin-induced diabetic rats.	Norepinephrine	76-89	arginine vasopressin	Rattus norvegicus	60-63
9637651-0	1998	Effect of propofol on norepinephrine-induced increases in [Ca2+]i and force in smooth muscle of the rabbit mesenteric resistance artery.	Norepinephrine	22-36	carbonic anhydrase 2	Oryctolagus cuniculus	59-62
9637651-4	1998	The effects of propofol on the [Ca2+]i mobilization induced by norepinephrine and high K+ were studied by simultaneous measurement of [Ca2+]i using Fura 2 and isometric force in ryanodine-treated strips.	Norepinephrine	63-77	carbonic anhydrase 2	Oryctolagus cuniculus	32-35
9637651-6	1998	In Ca2+-free solution, norepinephrine produced a transient contraction resulting from the release of Ca2+ from storage sites that propofol attenuated.	Norepinephrine	23-37	carbonic anhydrase 2	Oryctolagus cuniculus	3-6
9637651-6	1998	In Ca2+-free solution, norepinephrine produced a transient contraction resulting from the release of Ca2+ from storage sites that propofol attenuated.	Norepinephrine	23-37	carbonic anhydrase 2	Oryctolagus cuniculus	101-104
9637651-7	1998	In ryanodine-treated strips, propofol increased the resting [Ca2+]i but attenuated the increases in [Ca2+]i and force induced by both high K+ and norepinephrine.	Norepinephrine	146-160	carbonic anhydrase 2	Oryctolagus cuniculus	101-104
9637651-9	1998	CONCLUSIONS: In smooth muscle of the rabbit mesenteric resistance artery, propofol attenuates norepinephrine-induced contractions due to an inhibition both of Ca2+ release and of Ca2+ influx through L-type Ca2+ channels.	Norepinephrine	94-108	carbonic anhydrase 2	Oryctolagus cuniculus	159-162
9632371-8	1998	Hydroxylation of 8 at the 2"-position gave 14 which enhanced not only the binding potency at the DAT by another 2-fold but also the selectivity at the DAT over the norepinephrine and serotonin transporters.	Norepinephrine	164-178	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	151-154
9622140-1	1998	Recently we have reported that insulin attenuates norepinephrine (NE)-induced vasoconstriction via a cyclic GMP-NO synthase pathway.	Norepinephrine	50-64	insulin	Homo sapiens	31-38
9670229-2	1998	The release of growth hormone (GH) from the anterior pituitary is regulated by hypothalamic peptides especially GH-releasing hormone (GHRH) and somatostatin, which in turn are controlled by classic neurotransmitters such as noradrenaline, dopamine, and acetylcholine, as well as negative feedback from GH and insulin-like growth factor-1.	Norepinephrine	224-237	growth hormone 1	Homo sapiens	15-29
9603211-0	1998	Restoration of norepinephrine and reversal of phenotypes in mice lacking dopamine beta-hydroxylase.	Norepinephrine	15-29	dopamine beta hydroxylase	Mus musculus	73-98
9603211-1	1998	Mice with a targeted disruption of the dopamine beta-hydroxylase (DBH) gene are unable to synthesize norepinephrine (NE) and epinephrine.	Norepinephrine	101-115	dopamine beta hydroxylase	Mus musculus	66-69
9676895-7	1998	In particular, IL-1beta increased the utilization of norepinephrine (NE) within the paraventricular nucleus, arcuate nucleus/median eminence, locus coeruleus, and prefrontal cortex, while the turnover of dopamine (DA) was evident in the arcuate nucleus/median eminence.	Norepinephrine	53-67	interleukin 1 beta	Mus musculus	15-23
9670229-2	1998	The release of growth hormone (GH) from the anterior pituitary is regulated by hypothalamic peptides especially GH-releasing hormone (GHRH) and somatostatin, which in turn are controlled by classic neurotransmitters such as noradrenaline, dopamine, and acetylcholine, as well as negative feedback from GH and insulin-like growth factor-1.	Norepinephrine	224-237	growth hormone 1	Homo sapiens	31-33
9670229-2	1998	The release of growth hormone (GH) from the anterior pituitary is regulated by hypothalamic peptides especially GH-releasing hormone (GHRH) and somatostatin, which in turn are controlled by classic neurotransmitters such as noradrenaline, dopamine, and acetylcholine, as well as negative feedback from GH and insulin-like growth factor-1.	Norepinephrine	224-237	growth hormone releasing hormone	Homo sapiens	112-132
9670229-2	1998	The release of growth hormone (GH) from the anterior pituitary is regulated by hypothalamic peptides especially GH-releasing hormone (GHRH) and somatostatin, which in turn are controlled by classic neurotransmitters such as noradrenaline, dopamine, and acetylcholine, as well as negative feedback from GH and insulin-like growth factor-1.	Norepinephrine	224-237	growth hormone releasing hormone	Homo sapiens	134-138
9670229-2	1998	The release of growth hormone (GH) from the anterior pituitary is regulated by hypothalamic peptides especially GH-releasing hormone (GHRH) and somatostatin, which in turn are controlled by classic neurotransmitters such as noradrenaline, dopamine, and acetylcholine, as well as negative feedback from GH and insulin-like growth factor-1.	Norepinephrine	224-237	growth hormone 1	Homo sapiens	112-114
9670229-2	1998	The release of growth hormone (GH) from the anterior pituitary is regulated by hypothalamic peptides especially GH-releasing hormone (GHRH) and somatostatin, which in turn are controlled by classic neurotransmitters such as noradrenaline, dopamine, and acetylcholine, as well as negative feedback from GH and insulin-like growth factor-1.	Norepinephrine	224-237	insulin like growth factor 1	Homo sapiens	309-337
9797193-13	1998	Angiotensin II potentiated the norepinephrine-stimulated contraction of arteries from rats in the control and P groups, but not that of arteries from rats in the groups treated with L-158,809.	Norepinephrine	31-45	angiotensinogen	Rattus norvegicus	0-14
9581734-7	1998	Multivariate analysis demonstrated that only a family history of hypertension (chi-square=7.59, p=0.0059) and ET-1 changes during HG (chi-square=4.23, p=0.0398) were predictive of blood pressure response to HG and that epinephrine and norepinephrine were not.	Norepinephrine	235-249	endothelin 1	Homo sapiens	110-114
9575962-2	1998	This study extends observations that demonstrated neuronal modulation of spontaneous interleukin-6 (IL-6) secretion in the spleen by norepinephrine (NE) and beta-endorphin.	Norepinephrine	133-147	interleukin 6	Mus musculus	85-98
9575962-2	1998	This study extends observations that demonstrated neuronal modulation of spontaneous interleukin-6 (IL-6) secretion in the spleen by norepinephrine (NE) and beta-endorphin.	Norepinephrine	133-147	interleukin 6	Mus musculus	100-104
9575962-5	1998	In the presence of 10(-7) M cortisol, addition of norepinephrine (NE; 10(-5) M) and isoproterenol (10(-6) and 10(-5) M) significantly increased spontaneous IL-6 secretion (+20%; P = 0.0280, P = 0.0005, and P = 0.0050, respectively).	Norepinephrine	50-64	interleukin 6	Mus musculus	156-160
9683925-6	1998	Noradrenaline, angiotensin II and L-NG-monomethyl arginine caused significant vasoconstriction (p < 0.001) in both patients and controls although angiotensin II caused significantly less vasoconstriction in patients (p = 0.01).	Norepinephrine	0-13	angiotensinogen	Homo sapiens	149-163
9523565-0	1998	Suppression of astroglial nitric oxide synthase expression by norepinephrine results from decreased NOS-2 promoter activity.	Norepinephrine	62-76	nitric oxide synthase 2	Rattus norvegicus	100-105
9612217-9	1998	Angiotensin-converting enzyme inhibitor therapy is associated with enhanced vasoconstriction to norepinephrine and angiotensin II, which may reflect upregulation of receptor-mediated events.	Norepinephrine	96-110	angiotensin I converting enzyme	Homo sapiens	0-29
9629257-4	1998	IL-1 beta activates afferent vagal fibers that terminate in the nucleus tractus solitarius, and communication via the vagus is responsible for much of the hyperalgesia, fever, anorexia, taste aversions, increased levels of plasma corticosteroid, and brain norepinephrine changes produced by intraperitoneal injections of IL-1 beta and LPS.	Norepinephrine	256-270	interleukin 1 beta	Homo sapiens	0-9
9629269-9	1998	IL-1 beta increased the concentration of norepinephrine in the KAT45 culture medium from 24.2 +/- 3.5 micrograms/mg protein (n = 6 controls, at 24 hours), to 33.2 +/- 3.5 (IL-1 beta 10 mg/ml) or to 42.9 +/- 8 (IL-1 beta 30 mg/ml).	Norepinephrine	41-55	interleukin 1 beta	Homo sapiens	0-9
9597412-8	1998	RESULTS: Growth hormone induced a significant fall in myocardial norepinephrine release in response to physical exercise (from 180 +/- 64 to 99 +/- 34 ng.min-1; P < 0.05).	Norepinephrine	65-79	growth hormone 1	Homo sapiens	9-23
9523565-1	1998	We previously demonstrated that norepinephrine (NE) inhibits induction of the calcium-independent isoform of nitric oxide synthase (NOS-2) in primary rat astrocyte cultures.	Norepinephrine	32-46	nitric oxide synthase 2	Rattus norvegicus	132-137
9535030-6	1998	Control rat preparations showed greatest sensitivity for ET-1 when put under low tension (pEC50: 8.1 +/- 0.1) compared with at the higher tension (pEC50: 7.7 +/- 0.1) and there were significant increases in maximum contractile responses to S6c (approximately 80%) and noradrenaline (approximately 60%) when put under high tension.	Norepinephrine	268-281	endothelin 1	Rattus norvegicus	57-61
9613850-1	1998	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of dopamine and norepinephrine.	Norepinephrine	87-101	tyrosine hydroxylase	Homo sapiens	0-20
9613850-1	1998	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of dopamine and norepinephrine.	Norepinephrine	87-101	tyrosine hydroxylase	Homo sapiens	22-24
9578133-0	1998	Opposing effects of intracerebroventricularly injected norepinephrine on oxytocin and vasopressin neurons in the paraventricular nucleus of the rat.	Norepinephrine	55-69	arginine vasopressin	Rattus norvegicus	86-97
9580082-5	1998	AVP (3x10[-9] mol/L) enhanced the contractions elicited by electrical field stimulation at 1, 2, and 4 Hz (by 80%, 70%, and 60%, respectively) and produced a leftward shift of the concentration-response curve to norepinephrine (half-maximal effective concentration decreased from 6.87x10[-7] to 1.04x10[-7] mol/L; P<.05).	Norepinephrine	212-226	arginine vasopressin	Homo sapiens	0-3
9580082-10	1998	CONCLUSIONS: The results suggest that low concentrations of AVP facilitate sympathetic neurotransmission and potentiate constrictor effects of norepinephrine in human saphenous veins.	Norepinephrine	143-157	arginine vasopressin	Homo sapiens	60-63
9482787-0	1998	A point mutation (D79N) of the alpha2A adrenergic receptor abolishes the antiepileptogenic action of endogenous norepinephrine.	Norepinephrine	112-126	adrenergic receptor, alpha 2a	Mus musculus	31-58
9570713-7	1998	These findings suggest that noradrenaline, released from the axon terminals originating from the caudal ventrolateral medulla, may participate in the regulation of gene transcription of arginine-vasopressin in response to physiological stimuli.	Norepinephrine	28-41	arginine vasopressin	Rattus norvegicus	195-206
9550640-1	1998	BACKGROUND: In non-diabetic subjects, an attenuated systemic norepinephrine (NE) responsiveness may contribute to the mechanisms of action of angiotensin-converting enzyme (ACE) inhibitor treatment.	Norepinephrine	61-75	angiotensin I converting enzyme	Homo sapiens	173-176
9519739-7	1998	The response, which developed slowly and had a time course similar to that of second-phase insulin release, was abolished by the physiological inhibitor norepinephrine.	Norepinephrine	153-167	insulin	Homo sapiens	91-98
9515031-1	1998	We previously reported that transforming growth factor-beta1 (TGF-beta1) potentiated alpha1-adrenergic and stretch-induced c-fos mRNA expression and norepinephrine (NE)-induced amino acid incorporation in rat cultured myocardial cells (MCs).	Norepinephrine	149-163	transforming growth factor, beta 1	Rattus norvegicus	28-60
9515031-1	1998	We previously reported that transforming growth factor-beta1 (TGF-beta1) potentiated alpha1-adrenergic and stretch-induced c-fos mRNA expression and norepinephrine (NE)-induced amino acid incorporation in rat cultured myocardial cells (MCs).	Norepinephrine	149-163	transforming growth factor, beta 1	Rattus norvegicus	62-71
9550640-1	1998	BACKGROUND: In non-diabetic subjects, an attenuated systemic norepinephrine (NE) responsiveness may contribute to the mechanisms of action of angiotensin-converting enzyme (ACE) inhibitor treatment.	Norepinephrine	61-75	angiotensin I converting enzyme	Homo sapiens	142-171
9570448-0	1998	Effects of endothelin-1 on norepinephrine-induced vasoconstriction in deoxycorticosterone acetate-salt hypertensive rats.	Norepinephrine	27-41	endothelin 1	Rattus norvegicus	11-23
9454842-1	1998	Chronic stimulation of brain neurons by angiotensin II (Ang II) results in a increase in norepinephrine (NE) uptake.	Norepinephrine	89-103	angiotensinogen	Homo sapiens	40-54
9454842-1	1998	Chronic stimulation of brain neurons by angiotensin II (Ang II) results in a increase in norepinephrine (NE) uptake.	Norepinephrine	89-103	angiotensinogen	Homo sapiens	56-62
9570448-7	1998	These results suggest that endothelin-1 enhances contractile responses to norepinephrine through endothelin ETB receptor.	Norepinephrine	74-88	endothelin 1	Rattus norvegicus	27-39
9551713-2	1998	In the present study, we determined the phosphorylation of the 20-kDa myosin light chain and examined the effects of inhibitors of calmodulin and myosin light chain kinase on the Mn2+-dependent norepinephrine-induced contraction in order to evaluate the contribution of phosphorylation to this contraction.	Norepinephrine	194-208	myosin light chain kinase, smooth muscle	Cavia porcellus	146-171
9504388-12	1998	Co-application of a number of drugs with actions on second messenger systems, in association with the second AMPA stimulus, revealed significant potentiation of the AMPA-induced release of [3H]-noradrenaline: forskolin (10 microM, +78%), Rp-cAMPS (100 microM, +65%), Ro 31-8220 (10 microM, +163%) and thapsigargin (100 pM, + 161%).	Norepinephrine	193-207	calmodulin 2, pseudogene 1	Rattus norvegicus	241-246
9551713-6	1998	These results suggest that the activation of myosin light chain kinase is essential for the development of Mn2+-dependent norepinephrine-induced contractions and that the phosphorylation of myosin light chain may act as a trigger for these contractions.	Norepinephrine	122-136	myosin light chain kinase, smooth muscle	Cavia porcellus	45-70
9625457-0	1998	Interleukin-1beta administered intracerebroventricularly stimulates the release of noradrenaline in the hypothalamic paraventricular nucleus via prostaglandin in the rat.	Norepinephrine	83-96	interleukin 1 beta	Rattus norvegicus	0-17
9625457-2	1998	administration of interleukin (IL)-1beta on the rectal temperature and the release of noradrenaline (NA) in the hypothalamic paraventricular nucleus (PVN) of the rat.	Norepinephrine	86-99	interleukin 1 beta	Rattus norvegicus	18-40
9462584-8	1998	Among the hemodynamic variables and the various neurohumoral factors, the plasma norepinephrine (NE) level showed an independent and significant positive relation with the plasma IL-6 level in patients with CHF.	Norepinephrine	81-95	interleukin 6	Homo sapiens	179-183
9426292-0	1998	Noradrenaline and ATP decrease the secretion of triglyceride and apoprotein B from perfused rat liver.	Norepinephrine	0-13	apolipoprotein B	Rattus norvegicus	65-77
9549646-6	1998	Dosage and venous diameter were fit to a Hill-type pharmacodynamic model in which norepinephrine acts as a vasoconstrictor and insulin counteracts varying fractions of norepinephrine constriction.	Norepinephrine	168-182	insulin	Homo sapiens	127-134
11995034-12	1998	Alternatively TNF alpha production may represent the result of the neuroendocrine response such as cortisol and norepinephrine, to the surgical/anaesthetic trauma which could be blocked by subarachnoid anaesthesia.	Norepinephrine	112-126	tumor necrosis factor	Homo sapiens	14-23
9426292-6	1998	The secretion of ApoB from the perfused liver was also inhibited by noradrenaline or ATP to about 70% of control.	Norepinephrine	68-81	apolipoprotein B	Rattus norvegicus	17-21
9426292-8	1998	Since ApoB is the major apoprotein in VLDL, these results suggest that the sympathetic neurotransmitters noradrenaline and ATP suppress the secretion of ApoB-containing lipoprotein including VLDL from the liver, probably acting on post-transcriptional processes.	Norepinephrine	105-118	apolipoprotein B	Rattus norvegicus	6-10
9426292-8	1998	Since ApoB is the major apoprotein in VLDL, these results suggest that the sympathetic neurotransmitters noradrenaline and ATP suppress the secretion of ApoB-containing lipoprotein including VLDL from the liver, probably acting on post-transcriptional processes.	Norepinephrine	105-118	apolipoprotein B	Rattus norvegicus	153-157
9489621-2	1998	2 Contractions to noradrenaline in the rat isolated prostatic vas deferens were antagonized by prazosin (9.4, 1.04+/-0.19, pA2 and Schild plot slope), 5-methyl urapidil (8.9, 1.10+/-0.13), BMY 7378 (6.4, 1.53+/-0.07) and RS 17053 (8.3, 1.13+/-0.18).	Norepinephrine	18-31	arginine vasopressin	Rattus norvegicus	62-65
9833158-1	1998	Angiotensin II is able to modulate both the presynaptic sympathetic system and the adrenal medulla resulting in an enhanced release of noradrenaline and adrenaline.	Norepinephrine	135-148	angiotensinogen	Rattus norvegicus	0-14
9833158-2	1998	Consequently, the inhibition of the converting enzyme by ACE inhibitors resulting in a lower concentration of angiotensin II or blockade of the specific AT1 receptors by AT1 receptor blocking agents should lead to a decrease in both noradrenaline and adrenaline release.	Norepinephrine	233-246	angiotensin I converting enzyme	Rattus norvegicus	57-60
9833158-2	1998	Consequently, the inhibition of the converting enzyme by ACE inhibitors resulting in a lower concentration of angiotensin II or blockade of the specific AT1 receptors by AT1 receptor blocking agents should lead to a decrease in both noradrenaline and adrenaline release.	Norepinephrine	233-246	angiotensinogen	Rattus norvegicus	110-124
9833158-6	1998	As could be demonstrated with losartan and HR 720, candesartan lowered AT1 receptor mediated angiotensin II-induced noradrenaline release in a dose-dependent manner.	Norepinephrine	116-129	angiotensinogen	Rattus norvegicus	93-107
9510417-1	1998	The intracortical organization of the noradrenaline (NA) and vasoactive intestinal polypeptide (VIP) systems provides ample opportunity for functional convergence, and accumulated evidence indicates that NA and VIP share certain cellular actions upon both neuronal and nonneuronal cortical elements.	Norepinephrine	38-51	vasoactive intestinal peptide	Rattus norvegicus	211-214
9453310-0	1998	Cytochrome P-450 metabolites mediate norepinephrine-induced mitogenic signaling.	Norepinephrine	37-51	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
9453310-1	1998	Norepinephrine (NE) stimulates release of arachidonic acid (AA) from tissue lipids in blood vessels, which is metabolized via cyclooxygenase, lipoxygenase (LO), and cytochrome P-450 (CYP-450) pathways to biologically active products.	Norepinephrine	0-14	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	165-181
9453310-1	1998	Norepinephrine (NE) stimulates release of arachidonic acid (AA) from tissue lipids in blood vessels, which is metabolized via cyclooxygenase, lipoxygenase (LO), and cytochrome P-450 (CYP-450) pathways to biologically active products.	Norepinephrine	0-14	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	183-190
9595417-0	1998	Endothelin-1 enhances pressor responses to norepinephrine: involvement of endothelin-B receptor.	Norepinephrine	43-57	endothelin 1	Rattus norvegicus	0-12
9595417-1	1998	We investigated the effects of endothelin-1 (ET-1) on pressor responses to norepinephrine (NE) in perfused rat mesenteric arteries.	Norepinephrine	75-89	endothelin 1	Rattus norvegicus	45-49
9786171-8	1998	Blockade experiments showed that the vasomotor responses to norepinephrine were blocked by prazosin, to NPY by BIBP 3226, acetylcholine by atropin, substance P by RP 67580, and the human alpha-CGRP response by human alpha-CGRP(8-37).	Norepinephrine	60-74	tachykinin precursor 1	Homo sapiens	148-159
9786171-8	1998	Blockade experiments showed that the vasomotor responses to norepinephrine were blocked by prazosin, to NPY by BIBP 3226, acetylcholine by atropin, substance P by RP 67580, and the human alpha-CGRP response by human alpha-CGRP(8-37).	Norepinephrine	60-74	calcitonin related polypeptide alpha	Homo sapiens	193-197
9786171-8	1998	Blockade experiments showed that the vasomotor responses to norepinephrine were blocked by prazosin, to NPY by BIBP 3226, acetylcholine by atropin, substance P by RP 67580, and the human alpha-CGRP response by human alpha-CGRP(8-37).	Norepinephrine	60-74	calcitonin related polypeptide alpha	Homo sapiens	222-226
16465289-3	1997	Moreover, noradrenaline, which has been described as having trophic effects on brown fat and accelerating the differentiation of brown adipocytes, is capable of dose-dependently preventing the TNF-alpha-induced apoptosis of brown fat cells.	Norepinephrine	10-23	tumor necrosis factor	Rattus norvegicus	193-202
9415717-1	1997	alpha 2-Adrenergic receptors (alpha 2-ARs) respond to norepinephrine and epinephrine to mediate diverse physiological effects.	Norepinephrine	54-68	adrenergic receptor, alpha 2a	Mus musculus	30-41
9359846-1	1997	Neuropeptide Y (NPY) significantly potentiates the constrictor actions of noradrenaline and ATP on blood vessels via a pertussis toxin (PTX)-sensitive mechanism involving Gi/o (alpha beta gamma) protein subunits (Gi/o, GTP-binding proteins sensitive to PTX).	Norepinephrine	74-87	pro-neuropeptide Y	Cricetulus griseus	0-14
9359846-1	1997	Neuropeptide Y (NPY) significantly potentiates the constrictor actions of noradrenaline and ATP on blood vessels via a pertussis toxin (PTX)-sensitive mechanism involving Gi/o (alpha beta gamma) protein subunits (Gi/o, GTP-binding proteins sensitive to PTX).	Norepinephrine	74-87	pro-neuropeptide Y	Cricetulus griseus	16-19
9374743-3	1997	The Y1 agonist [Leu31,Pro34]NPY caused a dose-dependent constriction of iris arterioles (50% effective concentration of 10(-8) M), but, at low concentrations (10(-9) and 10(-10) M), it failed to potentiate either submaximal responses to norepinephrine (10(-6) M) or submaximal, noradrenergic responses to nerve stimulation.	Norepinephrine	237-251	neuropeptide Y	Rattus norvegicus	28-31
9374743-4	1997	In contrast, 10(-7) M [Leu31,Pro34]NPY potentiated submaximal, noradrenergic responses to nerve stimulation (10 Hz, < or = 1 s) and to a concentration of norepinephrine (10(-7) M) which produced only small contractions.	Norepinephrine	157-171	neuropeptide Y	Rattus norvegicus	35-38
9374743-9	1997	Results suggest that NPY, released from sympathetic nerves during long-duration, high-frequency stimulation, activates Y1 receptors on iris arterioles to produce vasoconstriction and to potentiate responses to low concentrations of norepinephrine.	Norepinephrine	232-246	neuropeptide Y	Rattus norvegicus	21-24
9351450-0	1997	Bradykinin B2-receptor activation augments norepinephrine exocytosis from cardiac sympathetic nerve endings.	Norepinephrine	43-57	B2 bradykinin receptor	Cavia porcellus	0-22
9383175-11	1997	CONCLUSION: These data suggest that bradykinin facilitates the release of noradrenaline in human and rat atrium by activation of bradykinin receptors of the B2-subtype and subsequent release of facilitatory prostaglandins.	Norepinephrine	74-87	kininogen 1	Homo sapiens	36-46
9383175-11	1997	CONCLUSION: These data suggest that bradykinin facilitates the release of noradrenaline in human and rat atrium by activation of bradykinin receptors of the B2-subtype and subsequent release of facilitatory prostaglandins.	Norepinephrine	74-87	kininogen 1	Homo sapiens	129-139
9334417-1	1997	The norepinephrine transporter (NET) is a membrane protein responsible for termination of the action of synaptic norepinephrine and is a site of action of many drugs used to treat major depression.	Norepinephrine	4-18	solute carrier family 6 member 2	Homo sapiens	32-35
9402037-0	1997	Cannabinoid CB1 receptor-mediated inhibition of noradrenaline release in the human and guinea-pig hippocampus.	Norepinephrine	48-61	cannabinoid receptor 1	Homo sapiens	12-15
9341183-11	1997	The effect of norepinephrine was abolished in membranes obtained from cells pretreated with endothelin-1.	Norepinephrine	14-28	endothelin 1	Rattus norvegicus	92-104
9322934-3	1997	The physiological activator of brown adipose tissue, norepinephrine, has a low mitogenic effect per se, but increases DNA synthesis stimulation exerted by serum, epidermal growth factor, basic fibroblast growth factor, and the neuropeptide vasopressin.	Norepinephrine	53-67	arginine vasopressin	Rattus norvegicus	240-251
9350584-0	1997	Role of endothelium in the endothelin-1-mediated potentiation of the norepinephrine response in the aorta of hypertensive rats.	Norepinephrine	69-83	endothelin 1	Rattus norvegicus	27-39
9350584-5	1997	In some experiments we examined the contractile responses to norepinephrine in aortas pretreated either with angiotensin II (AII) or with U46619, an agonist of prostaglandin H2-thromboxane A2 receptors.	Norepinephrine	61-75	angiotensinogen	Rattus norvegicus	109-123
9350584-5	1997	In some experiments we examined the contractile responses to norepinephrine in aortas pretreated either with angiotensin II (AII) or with U46619, an agonist of prostaglandin H2-thromboxane A2 receptors.	Norepinephrine	61-75	angiotensinogen	Rattus norvegicus	125-128
9350584-6	1997	Finally, we examined the effect of the combination of calcium-entry blockade by administration of nifedipine and treatment with either endothelin-1 or U46619 on the norepinephrine reactivity.	Norepinephrine	165-179	endothelin 1	Rattus norvegicus	135-147
9350584-7	1997	RESULTS: Administration of 3 x 10(-10) mol/l endothelin-1 potentiated the contractile response to norepinephrine in SHR aortas with endothelium, irrespective of whether they had been treated with NLA.	Norepinephrine	98-112	endothelin 1	Rattus norvegicus	45-57
9350584-10	1997	The amplification by endothelin-1 of the response to (1-100) x 10(-9) mol/l norepinephrine was abolished by blockade of the cyclooxygenase pathway with piroxicam or SO29548.	Norepinephrine	76-90	endothelin 1	Rattus norvegicus	21-33
9350584-12	1997	Administration of 3 x 10(-6) mol/l BQ-123 abolished the increase in reactivity to norepinephrine evoked by endothelin-1 in intact SHR aorta, whereas 3 x 10(-6) mol/l BQ-788 failed to modify this potentiating effect.	Norepinephrine	82-96	endothelin 1	Rattus norvegicus	107-119
9350584-13	1997	Administration of 10(-8) mol/l nifedipine inhibited the potentiation of the norepinephrine-induced contractions evoked both by endothelin-1 in SHR aortic rings with endothelium and by U46619 in SHR denuded rings.	Norepinephrine	76-90	endothelin 1	Rattus norvegicus	127-139
9350584-14	1997	CONCLUSION: Our results show that a low concentration of endothelin-1 induced potentiation of the contractile response to norepinephrine in SHR aortas but not in WKY rat aortas.	Norepinephrine	122-136	endothelin 1	Rattus norvegicus	57-69
9350584-17	1997	We propose that endothelin-1 stimulates the production of endothelium- and cyclooxygenase-generated vasoconstrictor factors, which in turn may serve directly as priming stimuli at the vascular smooth muscle level, to activate the Ca(2+)-signal pathway and consequently to increase locally the vascular sensitivity to norepinephrine.	Norepinephrine	317-331	endothelin 1	Rattus norvegicus	16-28
9321856-4	1997	As expected, the positive inotropic effect induced by an adenylyl cyclase activator, forskolin (2 x 10(-7) M), or a beta 1-AR agonist, norepinephrine (5 x 10(-8) M) plus prazosin (10(-6) M), was completely blocked by Rp-CPT-cAMPS.	Norepinephrine	135-149	calmodulin 2, pseudogene 1	Rattus norvegicus	224-229
9378233-6	1997	Presynaptic 5-HT 1B/D receptors take part in the control of the release not only of 5-HT itself, but also of other neurotransmitters-for example, acetylcholine, glutamate, dopamine, noradrenaline and gamma-aminobutyric acid.	Norepinephrine	182-195	5-hydroxytryptamine receptor 1B	Homo sapiens	12-19
9300319-1	1997	Calcitonin gene-related peptide (CGRP), carbamylcholine, and vasoactive intestinal peptide (VIP) caused a concentration-related relaxation in mouse aorta precontracted to noradrenaline.	Norepinephrine	171-184	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	0-31
9300319-1	1997	Calcitonin gene-related peptide (CGRP), carbamylcholine, and vasoactive intestinal peptide (VIP) caused a concentration-related relaxation in mouse aorta precontracted to noradrenaline.	Norepinephrine	171-184	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	33-37
9300319-1	1997	Calcitonin gene-related peptide (CGRP), carbamylcholine, and vasoactive intestinal peptide (VIP) caused a concentration-related relaxation in mouse aorta precontracted to noradrenaline.	Norepinephrine	171-184	vasoactive intestinal polypeptide	Mus musculus	92-95
9307243-1	1997	Systemic administration of endotoxin (LPS) or interleukin-1beta (IL-1) to prepubertal rats induced a marked increase in splenic but not cardiac norepinephrine (NE) turnover, an index of sympathetic neural activity.	Norepinephrine	144-158	interleukin 1 beta	Rattus norvegicus	46-63
9322222-6	1997	Norepinephrine increased release of NO as measured by determining the content of the enzyme at the end of the experiment (30 min) by adding [14C]arginine to the homogenate and measuring its conversion to [14C]citrulline since this is formed in equimolar quantities with NO by nitric oxide synthase (NOS).	Norepinephrine	0-14	nitric oxide synthase 2	Homo sapiens	276-297
9322222-7	1997	Since this increase in content presumably caused by activation of the enzyme by norepinephrine was blocked by the alpha 1 receptor blocker prazosin, it appears that alpha 1 receptors activate NOS by increasing intracellular free calcium in the NOergic neuron which combines with calmodulin to activate nitric oxide synthase.	Norepinephrine	80-94	calmodulin 1	Homo sapiens	279-289
9322222-7	1997	Since this increase in content presumably caused by activation of the enzyme by norepinephrine was blocked by the alpha 1 receptor blocker prazosin, it appears that alpha 1 receptors activate NOS by increasing intracellular free calcium in the NOergic neuron which combines with calmodulin to activate nitric oxide synthase.	Norepinephrine	80-94	nitric oxide synthase 2	Homo sapiens	302-323
9286946-1	1997	BACKGROUND: In congestive heart failure ACE inhibitors chronically reduce plasma norepinephrine.	Norepinephrine	81-95	angiotensin I converting enzyme	Homo sapiens	40-43
9283721-3	1997	Nepicastat is a novel inhibitor of dopamine-beta-hydroxylase, the enzyme which catalyses the conversion of dopamine to noradrenaline in sympathetic nerves.	Norepinephrine	119-132	dopamine beta-hydroxylase	Canis lupus familiaris	35-60
9283721-20	1997	The findings of this study suggest that nepicastat is a potent, selective and orally active inhibitor of dopamine-beta-hydroxylase which produces gradual modulation of the sympathetic nervous system by inhibiting the biosynthesis of noradrenaline.	Norepinephrine	233-246	dopamine beta-hydroxylase	Canis lupus familiaris	105-130
9199450-6	1997	In addition, norepinephrine stimulated the growth-promoting effect induced by human transferrin in iron-limited medium.	Norepinephrine	13-27	transferrin	Homo sapiens	84-95
9202305-0	1997	Impact of corticotropin-releasing hormone on extracellular norepinephrine in prefrontal cortex after chronic cold stress.	Norepinephrine	59-73	corticotropin releasing hormone	Rattus norvegicus	10-41
9256089-3	1997	AII infusion resulted in a significant elevation in mean arterial pressure and in plasma AII and noradrenaline levels.	Norepinephrine	97-110	angiotensinogen	Rattus norvegicus	0-3
9256089-5	1997	After AII infusion, in MrA (i) maximal contractile responses to 125 mM K+, noradrenaline, serotonin and adrenergic nerve stimulation were significantly increased, without modification of the sensitivity to these stimuli and (ii) a significant increase in media cross-sectional area and media thickness was observed without alterations in lumen diameter.	Norepinephrine	75-88	angiotensinogen	Rattus norvegicus	6-9
9189272-0	1997	Disruption of the dopamine beta-hydroxylase gene in mice suggests roles for norepinephrine in motor function, learning, and memory.	Norepinephrine	76-90	dopamine beta hydroxylase	Mus musculus	18-43
9278773-12	1997	In addition, neuropeptide Y also potentiated the response to noradrenaline, i.e. lowered its EC50 but this enhancement was also small.	Norepinephrine	61-74	neuropeptide Y	Rattus norvegicus	13-27
9278773-14	1997	We conclude that noradrenaline contracts rat interlobar arteries by an alpha(1)A-adrenoceptor; its co-transmitter, neuropeptide Y, affects the response only marginally in this vascular bed.	Norepinephrine	17-30	neuropeptide Y	Rattus norvegicus	115-129
9112390-3	1997	or into the fourth ventricle, stimulated the release of norepinephrine (NE) into the hypothalamic paraventricular nucleus (PVN), the site of neurons containing CRH.	Norepinephrine	56-70	corticotropin releasing hormone	Rattus norvegicus	160-163
9114781-1	1997	In a group of patients with New York Heart Association class IV heart failure, significant relations between interleukin-6 and tumor necrosis factor-alpha, and between levels of both interleukin-6 and tumor necrosis factor-alpha and plasma levels of norepinephrine were observed.	Norepinephrine	250-264	interleukin 6	Homo sapiens	109-154
9114781-1	1997	In a group of patients with New York Heart Association class IV heart failure, significant relations between interleukin-6 and tumor necrosis factor-alpha, and between levels of both interleukin-6 and tumor necrosis factor-alpha and plasma levels of norepinephrine were observed.	Norepinephrine	250-264	interleukin 6	Homo sapiens	183-228
9092590-1	1997	Chemical signaling by dopamine (DA) and L-norepinephrine (L-NE) at synapses is terminated by uptake via specialized presynaptic transport proteins encoded by the DA transporter (DAT) and L-NE transporter (NET) genes, respectively.	Norepinephrine	40-56	solute carrier family 6 member 2	Homo sapiens	205-208
9092590-1	1997	Chemical signaling by dopamine (DA) and L-norepinephrine (L-NE) at synapses is terminated by uptake via specialized presynaptic transport proteins encoded by the DA transporter (DAT) and L-NE transporter (NET) genes, respectively.	Norepinephrine	58-62	solute carrier family 6 member 2	Homo sapiens	205-208
9142915-10	1997	However, in portal hypertensive rats, Rp-cAMPS reduced blood flow by approximately 20% (P < 0.05) and completely restored vascular norepinephrine responses to normal.	Norepinephrine	134-148	calmodulin 2, pseudogene 1	Rattus norvegicus	41-46
9147017-2	1997	Fluoxetine and fluvoxamine reinforced the response to norepinephrine of isolated rat vas deferens incubated in Krebs-Henseleit solution.	Norepinephrine	54-68	arginine vasopressin	Rattus norvegicus	85-88
9156355-7	1997	The experiments performed on the segments of IMA, used for myocardial revascularization of patients affected by coronary diseases, have shown an evident spasmolytic action of CGRP on increased vascular tone induced by KCl (90 mM), noradrenaline (10(-5) M), serotonin (10(-6) M), and angiotensin II (10(-6) M).	Norepinephrine	231-244	calcitonin related polypeptide alpha	Homo sapiens	175-179
9098556-0	1997	Neuropeptide Y and [Leu31,Pro34]neuropeptide Y potentiate potassium-induced noradrenaline release in the paraventricular nucleus of the aged rat.	Norepinephrine	76-89	neuropeptide Y	Rattus norvegicus	0-14
9098556-0	1997	Neuropeptide Y and [Leu31,Pro34]neuropeptide Y potentiate potassium-induced noradrenaline release in the paraventricular nucleus of the aged rat.	Norepinephrine	76-89	neuropeptide Y	Rattus norvegicus	32-46
9098556-1	1997	This microdialysis study investigated the effects of NPY and the Y1 selective agonist [Leu31, Pro34]NPY on basal and potassium-stimulated noradrenaline release in the PVN of 18-month-old anaesthetised male Sprague-Dawley rats.	Norepinephrine	138-151	neuropeptide Y	Rattus norvegicus	100-103
9098556-4	1997	[Leu31, Pro34]NPY produced a significant 40% reduction in basal noradrenaline concentration (P < 0.05).	Norepinephrine	64-77	neuropeptide Y	Rattus norvegicus	14-17
9098556-6	1997	[Leu31, Pro34]NPY induced a significantly greater release of noradrenaline in response to KC1 (5.0 times resting, P < 0.05).	Norepinephrine	61-74	neuropeptide Y	Rattus norvegicus	14-17
9098556-7	1997	Thus, in 18-month-old animals with reduced endogenous hypothalamic NPY content, administration of NPY or [Leu31, Pro34]NPY increased potassium-induced noradrenaline release to levels seen in 3-month-old rats.	Norepinephrine	151-164	neuropeptide Y	Rattus norvegicus	98-101
9098556-7	1997	Thus, in 18-month-old animals with reduced endogenous hypothalamic NPY content, administration of NPY or [Leu31, Pro34]NPY increased potassium-induced noradrenaline release to levels seen in 3-month-old rats.	Norepinephrine	151-164	neuropeptide Y	Rattus norvegicus	98-101
9087579-2	1997	The aim of the present study was to investigate whether subpressor concentrations of vasopressin could modify the constrictor responses to norepinephrine and electrical stimulation of the perivascular nerves in human mesenteric arteries.	Norepinephrine	139-153	arginine vasopressin	Homo sapiens	85-96
9087579-5	1997	Vasopressin (3 x 10(-11) M) enhanced the contractions elicited by electrical stimulation at 2, 4, and 8 Hz (by 100, 100, and 72%, respectively) and produced a leftward shift of the concentration-response curves to norepinephrine (half-maximal effective concentration decreased from 2.2 x 10(-6) to 5.0 x 10(-7) M; P < 0.05) without any alteration in maximal contractions.	Norepinephrine	214-228	arginine vasopressin	Homo sapiens	0-11
9080371-7	1997	The phospholipase C (PLC) inhibitor U73122 inhibited the amplitude of the noradrenaline-activated Icat in a concentration- and time-dependent manner and the IC50 was about 180 nM.	Norepinephrine	74-87	LOC100009319	Oryctolagus cuniculus	4-19
9080371-7	1997	The phospholipase C (PLC) inhibitor U73122 inhibited the amplitude of the noradrenaline-activated Icat in a concentration- and time-dependent manner and the IC50 was about 180 nM.	Norepinephrine	74-87	LOC100009319	Oryctolagus cuniculus	21-24
9080371-17	1997	It is concluded that noradrenaline activates Icat via a G-protein coupled to PLC and that the resulting DAG product plays a central role in the activation of cation channels via a protein kinase C-independent mechanism.	Norepinephrine	21-34	LOC100009319	Oryctolagus cuniculus	77-80
9032464-11	1997	It is concluded that the physiologically induced increase in LPL gene expression is a direct effect of noradrenaline on the brown adipocytes themselves, mediated via a dominant beta3-adrenergic pathway and an auxiliary alpha1-adrenergic pathway which converge at a regulatory point in transcriptional control.	Norepinephrine	103-116	lipoprotein lipase	Rattus norvegicus	61-64
9059313-7	1997	Noradrenaline caused a mean reduction in basal blood flow of 34-51% (P < 0.001), and augmented the percentage increases in blood flow with both substance P (P = 0.05) and acetylcholine (P = 0.03) infusions.	Norepinephrine	0-13	tachykinin precursor 1	Homo sapiens	147-158
9135698-14	1997	The response of noradrenaline to hypoglycaemia correlated inversely with fasting insulin levels in the women with PCOS.	Norepinephrine	16-29	insulin	Homo sapiens	81-88
9471921-17	1997	The daily excretion of adrenaline and noradrenaline in urine concentrations of dopamine in plasma of women chronically exposed to CS2, was significantly lower (p < 0.001), but the serum concentrations of serotonin (Tab.	Norepinephrine	38-51	chorionic somatomammotropin hormone 2	Homo sapiens	130-133
9288827-0	1997	Beta-endorphin inhibition of endogenous norepinephrine release from the A2 noradrenergic nucleus in vitro: role of mu opiate receptors and Na+ ion permeability.	Norepinephrine	40-54	proopiomelanocortin	Homo sapiens	0-14
9288827-1	1997	An in vitro approach was used to determine the opioid receptor subtype mediating beta-endorphin inhibition of endogenous norepinephrine release from the A2 nucleus in the caudal dorsomedial medulla of rats.	Norepinephrine	121-135	proopiomelanocortin	Homo sapiens	81-95
9288827-2	1997	The voltage-sensitive Na+ channel blocker tetrodotoxin was used to investigate the role of Na+-dependent action potentials in beta-endorphin inhibition of K+-evoked norepinephrine release.	Norepinephrine	165-179	proopiomelanocortin	Homo sapiens	126-140
9288827-3	1997	Human beta-endorphin(1-31) inhibited K+-evoked norepinephrine release in a concentration-dependent fashion.	Norepinephrine	47-61	proopiomelanocortin	Homo sapiens	6-20
8995987-12	1997	CONCLUSIONS: In patients with congestive heart failure, the net release of plasma beta-endorphin during exercise is decreased, like norepinephrine, and reflects a functional disability.	Norepinephrine	132-146	proopiomelanocortin	Homo sapiens	82-96
9039139-9	1997	Impaired contractions to endothelin-1 and norepinephrine in the angiotensin II group were normalized after treatment with LU135252 (P < .05).	Norepinephrine	42-56	angiotensinogen	Rattus norvegicus	64-78
9039140-14	1997	The afferent arteriolar response to norepinephrine was enhanced in renal-denervated, Ang II-infused, and Ang II-infused+renal-denervated rats compared with sham controls.	Norepinephrine	36-50	angiotensinogen	Rattus norvegicus	85-91
8996233-5	1997	The periarterial nerve stimulation (10 V, 4-16 Hz, for 45 sec), exogenous CGRP (10(-8) M) or the ATP-sensitive K+ channel opener cromakalim (10(-6) M) produced relaxation of the rings at a stable plateau tension by the addition of norepinephrine (10(-5) M); the relaxations elicited by CGRP and cromakalim were human CGRP-(8-37)- and glibenclamide-abolishable, respectively.	Norepinephrine	231-245	calcitonin related polypeptide alpha	Homo sapiens	74-78
8982720-2	1996	Intracerebroventricular administration of interleukin-1 beta induced a gradually developing elevation of plasma noradrenaline levels in a dose-dependent manner (50, 100 and 200 ng/animal), while the levels of adrenaline were not affected.	Norepinephrine	112-125	interleukin 1 beta	Rattus norvegicus	42-60
8977143-0	1996	Down-regulation or long-term inhibition of protein kinase C (PKC) reduces noradrenaline release evoked via either PKC-dependent or PKC-independent pathways in human SH-SY5Y neuroblastoma cells.	Norepinephrine	74-87	proline rich transmembrane protein 2	Homo sapiens	43-59
8977143-0	1996	Down-regulation or long-term inhibition of protein kinase C (PKC) reduces noradrenaline release evoked via either PKC-dependent or PKC-independent pathways in human SH-SY5Y neuroblastoma cells.	Norepinephrine	74-87	proline rich transmembrane protein 2	Homo sapiens	61-64
8977143-0	1996	Down-regulation or long-term inhibition of protein kinase C (PKC) reduces noradrenaline release evoked via either PKC-dependent or PKC-independent pathways in human SH-SY5Y neuroblastoma cells.	Norepinephrine	74-87	proline rich transmembrane protein 2	Homo sapiens	114-117
8977143-1	1996	Long-term (8-48 h) treatment of SH-SY5Y neuroblastoma cells with phorbol-12,13-dibutyrate (PDBu; 100 nM) promotes the down-regulation of protein kinase C (PKC) subtypes alpha and epsilon and reduces by up to 60% noradrenaline (NA) release evoked via both PKC-dependent (M3-muscarinic receptor activation) and PKC-independent (depolarization) pathways, over similar time courses.	Norepinephrine	212-225	proline rich transmembrane protein 2	Homo sapiens	137-153
8977143-1	1996	Long-term (8-48 h) treatment of SH-SY5Y neuroblastoma cells with phorbol-12,13-dibutyrate (PDBu; 100 nM) promotes the down-regulation of protein kinase C (PKC) subtypes alpha and epsilon and reduces by up to 60% noradrenaline (NA) release evoked via both PKC-dependent (M3-muscarinic receptor activation) and PKC-independent (depolarization) pathways, over similar time courses.	Norepinephrine	212-225	proline rich transmembrane protein 2	Homo sapiens	155-158
8968540-6	1996	Artery rings from patients with a positive bronchodilator response showed greater contraction to noradrenaline (pD2 = 6.44 +/- 0.1; Emax = 93 +/- 9% of response to 100 mM KCl) and endothelin-1 (pD2 = 8.92 +/- 0.1; Emax = 130 +/- 16%) than the rings from control patients (pD2 = 6.04 +/- 0.08; Emax = 56 +/- 8% for noradrenaline; pD2 = 8.29 +/- 0.1; Emax = 78 +/- 10% for endothelin-1).	Norepinephrine	97-110	endothelin 1	Homo sapiens	371-383
8968540-6	1996	Artery rings from patients with a positive bronchodilator response showed greater contraction to noradrenaline (pD2 = 6.44 +/- 0.1; Emax = 93 +/- 9% of response to 100 mM KCl) and endothelin-1 (pD2 = 8.92 +/- 0.1; Emax = 130 +/- 16%) than the rings from control patients (pD2 = 6.04 +/- 0.08; Emax = 56 +/- 8% for noradrenaline; pD2 = 8.29 +/- 0.1; Emax = 78 +/- 10% for endothelin-1).	Norepinephrine	314-327	endothelin 1	Homo sapiens	180-192
8968542-8	1996	Three days after 6-OHDA treatment there was an increase in the sensitivities of response to vasopressin and endothelin, producing leftward shifts of the dose-response curves of 0.66 +/- 0.11 and 0.88 +/- 0.13 log units respectively (n = 7-11), and a small increase in sensitivity of responses to noradrenaline (NA) and ATP.	Norepinephrine	296-309	arginine vasopressin	Rattus norvegicus	92-103
9128405-10	1996	We performed bolus infusion tests of noradrenaline and isoprenaline on patients with OH, and found that alpha-adrenoceptor-mediated rise in blood pressure was comparable to control, beta 1-mediated increase in heart rate was blunted, and beta 2-mediated fall in blood pressure was enhanced in OH.	Norepinephrine	37-50	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	182-188
8922747-7	1996	Angiotensin II (0.1-3 microM) produced concentration-dependent enhancement of both stimulation-induced (S-I) efflux of [3H]-noradrenaline and stimulation-evoked vasoconstrictor responses in isolated preparations of caudal artery from both SH and WKY rats, in which the noradrenergic transmitter stores had been labelled with [3H]-noradrenaline.	Norepinephrine	124-137	angiotensinogen	Rattus norvegicus	0-14
8873692-7	1996	Vascular sensitivity to insulin was inversely correlated with mean arterial pressure and plasma norepinephrine concentration.	Norepinephrine	96-110	insulin	Homo sapiens	24-31
8897002-1	1996	Insulin increases both cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) in human vascular smooth muscle cells (hVSMC) and attenuates noradrenaline-induced vasoconstriction.	Norepinephrine	164-177	insulin	Homo sapiens	0-7
8862135-1	1996	Tumor necrosis factor-alpha (TNF alpha) and the imidazoline clonidine modulate norepinephrine (NE) release from noradrenergic nerve terminals in the central nervous system.	Norepinephrine	79-93	tumor necrosis factor	Rattus norvegicus	0-27
8862135-1	1996	Tumor necrosis factor-alpha (TNF alpha) and the imidazoline clonidine modulate norepinephrine (NE) release from noradrenergic nerve terminals in the central nervous system.	Norepinephrine	79-93	tumor necrosis factor	Rattus norvegicus	29-38
8897441-6	1996	In contrast, noradrenaline increased the level of proenkephalin mRNA in a concentration-dependent manner.	Norepinephrine	13-26	proenkephalin	Homo sapiens	50-63
9438155-9	1996	beta-endorphin IRM concentrations were correlated negatively to heart rate (-0.55; p < 0.0005) and positively to the noradrenaline concentration (0.56; p < 0.0004).	Norepinephrine	120-133	proopiomelanocortin	Homo sapiens	0-14
9438155-12	1996	CONCLUSION: It is concluded that beta-endorphin IRM concentration in the plasma is linked to epinephrine and norepinephrine concentrations under intensive care conditions.	Norepinephrine	109-123	proopiomelanocortin	Homo sapiens	33-47
8897640-3	1996	The aim of the present work was to investigate BNP and CNP effects on the uptake and release of norepinephrine (NE) in rat hypothalamic slices incubated in vitro.	Norepinephrine	96-110	natriuretic peptide B	Rattus norvegicus	47-50
8891597-10	1996	It is concluded that endothelin-1 at low concentrations activates prejunctional endothelin ETA receptors and inhibits adrenergic nerve-mediated contractions by an inhibition of amine release, whereas the peptide at high concentrations potentiates the neurally induced contractions by a postjunctional enhancement, via endothelin ETA receptors, of the action of norepinephrine.	Norepinephrine	361-375	endothelin 1	Canis lupus familiaris	21-33
8794928-1	1996	Rotating disk electrode (RDE) voltammetry is applied to the measurement of the transport of the catecholamine neurotransmitters norepinephrine (4-(2-amino-1-hydroxyethyl)-1,2-benzenediol, NE) and dopamine (3,4-dihydroxyphenethylamine, DA) in suspensions of LLC-NET cells, a line of porcine kidney cells expressing the human norepinephrine transporter (hNET).	Norepinephrine	128-142	solute carrier family 6 member 2	Homo sapiens	261-264
8794928-1	1996	Rotating disk electrode (RDE) voltammetry is applied to the measurement of the transport of the catecholamine neurotransmitters norepinephrine (4-(2-amino-1-hydroxyethyl)-1,2-benzenediol, NE) and dopamine (3,4-dihydroxyphenethylamine, DA) in suspensions of LLC-NET cells, a line of porcine kidney cells expressing the human norepinephrine transporter (hNET).	Norepinephrine	128-142	solute carrier family 6 member 2	Homo sapiens	324-350
8794928-1	1996	Rotating disk electrode (RDE) voltammetry is applied to the measurement of the transport of the catecholamine neurotransmitters norepinephrine (4-(2-amino-1-hydroxyethyl)-1,2-benzenediol, NE) and dopamine (3,4-dihydroxyphenethylamine, DA) in suspensions of LLC-NET cells, a line of porcine kidney cells expressing the human norepinephrine transporter (hNET).	Norepinephrine	128-142	solute carrier family 6 member 2	Homo sapiens	352-356
8898322-5	1996	The increased noradrenaline content may increase the concentration of galanin, which will decrease the circulating levels of insulin and increase the pace of transcription of the neuropeptide Y gene.	Norepinephrine	14-27	insulin	Homo sapiens	125-132
9863165-0	1996	Direct evidence for histamine H3 receptor-mediated inhibition of norepinephrine release from sympathetic terminals of guinea pig myocardium.	Norepinephrine	65-79	histamine H3 receptor	Cavia porcellus	20-41
8710929-5	1996	Here we report channel-like events from a presumably fixed stoichiometry [norepinephrine (NE)+, Na+, and Cl-], human NE (hNET) in the gamma-aminobutyric acid transporter gene family.	Norepinephrine	74-88	solute carrier family 6 member 2	Homo sapiens	121-125
8842454-17	1996	Angiotensin II (0.1 mumol l-1 enhanced noradrenaline release resulting in a S2/S1 ratio of 1.44 (1.34-1.54), while the angiotensin II antagonist, losartan (1 mumol l-1) had no effect on noradrenaline release during normoxia.	Norepinephrine	39-52	angiotensinogen	Homo sapiens	0-14
8842454-17	1996	Angiotensin II (0.1 mumol l-1 enhanced noradrenaline release resulting in a S2/S1 ratio of 1.44 (1.34-1.54), while the angiotensin II antagonist, losartan (1 mumol l-1) had no effect on noradrenaline release during normoxia.	Norepinephrine	186-199	angiotensinogen	Homo sapiens	0-14
8842454-20	1996	In conclusion, human cardiac tissue possesses presynaptic inhibitory alpha 2-adrenoceptors and adenosine receptors, as well as facilitatory beta 2-adrenoceptors and angiotensin II receptors regulating noradrenaline release under normoxic conditions.	Norepinephrine	201-214	angiotensinogen	Homo sapiens	165-179
8707386-6	1996	Ang II significantly increased norepinephrine turnover in the organum vasculosum lamina terminalis and ventral median preoptic nucleus of SHR (organum vasculosum lamina terminalis: 40 +/- 5% by Ang II versus 18 +/- 6% by saline, P < .05; ventral median preoptic nucleus: 32 +/- 3% by Ang II versus 21 +/- 2% by saline, P < .05) but not of WKY (37 +/- 5% versus 29 +/- 5%, P = NS, and 30 +/- 2% versus 32 +/- 3%, P = NS, respectively).	Norepinephrine	31-45	angiotensinogen	Rattus norvegicus	0-6
8707386-7	1996	Thus, norepinephrine turnover in the anteroventral third ventricle region induced by intracerebroventricular administration of Ang II was increased in SHR.	Norepinephrine	6-20	angiotensinogen	Rattus norvegicus	127-133
8814528-4	1996	Many studies have demonstrated that angiotensin converting enzyme (ACE) inhibitors reduce the level of angiotensin II and plasma norepinephrine, and improve long-term hemodynamics and survival in patients with chronic heart failure.	Norepinephrine	129-143	angiotensin I converting enzyme	Homo sapiens	36-65
8814528-4	1996	Many studies have demonstrated that angiotensin converting enzyme (ACE) inhibitors reduce the level of angiotensin II and plasma norepinephrine, and improve long-term hemodynamics and survival in patients with chronic heart failure.	Norepinephrine	129-143	angiotensin I converting enzyme	Homo sapiens	67-70
8674327-14	1996	The infusion of norepinephrine decreased renal blood flow from 1241 +/- 208 to 922 +/- 143 mL/min/1.73 m2 (p = .03).	Norepinephrine	16-30	CD59 molecule (CD59 blood group)	Homo sapiens	94-99
8674891-5	1996	With a 2-h insulin infusion, serum norepinephrine, epinephrine, plasminogen activator inhibitor 1, and intraplatelet Ca2+ decreased significantly, but 6-keto-prostaglandin (PG) F1 alpha and PGE2 did not change.	Norepinephrine	35-49	insulin	Homo sapiens	11-18
8809522-9	1996	(2) In mode 10/60 s, heart rate and systolic blood pressure increased significantly (82 +/- 4 --> 85 +/- 4 beats.min-1; 124 +/- 5 --> 134 +/- 5 mmHg; P < 0.05 each), while in mode 15/60 s catecholamines increased significantly (norepinephrine 0.804 +/- 0.089 --> 1.135 +/- 0.094 nmol.l-1; P < 0.008; epinephrine 0.136 +/- 0.012 --> 0.193 +/- 0.019 nmol.l-1; P < 0.005).	Norepinephrine	237-251	CD59 molecule (CD59 blood group)	Homo sapiens	116-121
8888369-1	1996	Prolactin (PRL) and melatonin (ML) secretion are mediated by dopamine (DA) and norepinephrine (NE), respectively.	Norepinephrine	79-93	prolactin	Homo sapiens	0-9
8888369-1	1996	Prolactin (PRL) and melatonin (ML) secretion are mediated by dopamine (DA) and norepinephrine (NE), respectively.	Norepinephrine	79-93	prolactin	Homo sapiens	11-14
8809840-2	1996	As far as secretory peptides are concerned noradrenaline granules contained slightly more secretogranin II, but much less chromogranin A than adrenaline granules.	Norepinephrine	43-56	chromogranin A	Bos taurus	122-136
8640984-0	1996	Endothelin-1 is involved in norepinephrine-induced ventricular hypertrophy in vivo.	Norepinephrine	28-42	endothelin 1	Rattus norvegicus	0-12
8640984-9	1996	Ventricular expression of ET-1 mRNA was elevated in the norepinephrine group at 1, 2, and 3 days.	Norepinephrine	56-70	endothelin 1	Rattus norvegicus	26-30
8640984-13	1996	CONCLUSIONS: These data suggest that endogenous ET-1 plays a direct role in mediating norepinephrine-induced ventricular hypertrophy in vivo.	Norepinephrine	86-100	endothelin 1	Rattus norvegicus	48-52
8641736-1	1996	Norepinephrine causes downregulation of angiotensin II (Ang II) receptors in Wistar-Kyoto rat (WKY) brain neuronal cultures.	Norepinephrine	0-14	angiotensinogen	Rattus norvegicus	40-54
8641736-1	1996	Norepinephrine causes downregulation of angiotensin II (Ang II) receptors in Wistar-Kyoto rat (WKY) brain neuronal cultures.	Norepinephrine	0-14	angiotensinogen	Rattus norvegicus	56-62
8641736-9	1996	Thus, these data show that norepinephrine-mediated downregulation of AT1 receptors is associated with a parallel decrease in AT1 mRNA and Ang II stimulation of norepinephrine transporter mRNA and involves the alpha1a-adrenergic receptor in neurons of WKY brain.	Norepinephrine	27-41	angiotensinogen	Rattus norvegicus	138-144
10968201-3	1996	EPO treatment was associated with significant increases in Hgb (7.1 +/- 1.4 to 8.4 +/- 1.8 g/dl, p<0.01), mean BP (103 +/- 11.4 to 116 +/- 19.9 mmHg, p<0.01), [Na+]i (4.99 +/- 0.78 to 6.22 +/- 0.96 mmol/l, p<0.01) and BV (1.39 +/- 0.14 to 1.53 +/- 0.18 c.p., p<0.05), but no significant alteration in PRA, PAC, Ad, NAd, ANP, or in the serum concentration of Na+, K+, and Ca2+.	Norepinephrine	327-330	erythropoietin	Homo sapiens	0-3
8667208-8	1996	In contradistinction, the toxicity of MPTP at the noradrenaline neurons in the primate cerebral cortex (Pifl et al., 1991) may involve the higher affinity of MPP+ for the noradrenaline transporter.	Norepinephrine	50-63	solute carrier family 6 member 2	Homo sapiens	171-196
8832581-0	1996	Interleukin-1 beta and tumor necrosis factor-alpha inhibit the release of [3H]-noradrenaline from mice isolated atria.	Norepinephrine	79-92	interleukin 1 beta	Mus musculus	0-50
8832581-8	1996	The ability of interleukin-1 beta and tumor necrosis factor-alpha to inhibit noradrenaline release suggests that mediators of the immune system produced locally may modulate the activity of the sympathetic nervous system.	Norepinephrine	77-90	interleukin 1 beta	Mus musculus	15-65
8832584-2	1996	Both noradrenaline and methoxamine produced dose-dependent venoconstriction; the geometric mean ED50 for noradrenaline was 4.15 ng min-1 and for methoxamine was 1143.54 ng min-1; the potency ratio (noradrenaline/methoxamine) was 277.	Norepinephrine	5-18	CD59 molecule (CD59 blood group)	Homo sapiens	131-136
8832584-2	1996	Both noradrenaline and methoxamine produced dose-dependent venoconstriction; the geometric mean ED50 for noradrenaline was 4.15 ng min-1 and for methoxamine was 1143.54 ng min-1; the potency ratio (noradrenaline/methoxamine) was 277.	Norepinephrine	5-18	CD59 molecule (CD59 blood group)	Homo sapiens	172-177
8832584-2	1996	Both noradrenaline and methoxamine produced dose-dependent venoconstriction; the geometric mean ED50 for noradrenaline was 4.15 ng min-1 and for methoxamine was 1143.54 ng min-1; the potency ratio (noradrenaline/methoxamine) was 277.	Norepinephrine	105-118	CD59 molecule (CD59 blood group)	Homo sapiens	131-136
8832584-2	1996	Both noradrenaline and methoxamine produced dose-dependent venoconstriction; the geometric mean ED50 for noradrenaline was 4.15 ng min-1 and for methoxamine was 1143.54 ng min-1; the potency ratio (noradrenaline/methoxamine) was 277.	Norepinephrine	105-118	CD59 molecule (CD59 blood group)	Homo sapiens	131-136
8817480-8	1996	The noradrenaline enhancement of creatine accumulation at 48 h was inhibited by the mixed alpha- and beta-antagonist labetalol and by the beta-antagonist propranolol, but was unaffected by the alpha 2 antagonist phentolamine; greater inhibition was caused by the beta 2 antagonist butoxamine than the beta 1 antagonist atenolol.	Norepinephrine	4-17	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	301-307
8633049-0	1996	Nitric oxide synthase content of hypothalamic explants: increase by norepinephrine and inactivated by NO and cGMP.	Norepinephrine	68-82	nitric oxide synthase 2	Homo sapiens	0-21
8736116-5	1996	These data indicate a correlation between noradrenergic pathways and angiotensinergic receptors and lead us to conclude that noradrenaline-induced water intake may be due to the release of ANG II by the brain.	Norepinephrine	125-138	angiotensinogen	Rattus norvegicus	189-195
8867047-0	1996	Arginine vasopressin release by acetylcholine or norepinephrine: region-specific and cytokine-specific regulation.	Norepinephrine	49-63	arginine vasopressin	Homo sapiens	9-20
8867047-2	1996	In the present study, we evaluated the effects of these cytokines on the in vitro release of arginine vasopressin, previously reported to be sensitive to neurotransmitters such as acetylcholine, norepinephrine, and corticotropin releasing hormone as well as to cytokines interleukin-1 and interleukin-2.	Norepinephrine	195-209	arginine vasopressin	Homo sapiens	102-113
8680871-1	1996	Control cagemates of rats treated with the norepinephrine (NE) neurotoxin DSP-4, showed normal olfactory learning as infants, but abnormal aversion to home-cage odors as juveniles.	Norepinephrine	43-57	dual specificity phosphatase 26	Homo sapiens	74-79
8670061-3	1996	Insulin increased 2-deoxyglucose (dGlc) uptake progressively at concentrations from 10(-11) to 10(-6) M, with maximal stimulation at 10(-7) M. Noradrenaline concentrations ranging from 10(-8) to 10(-6) M also enhanced dGlc uptake, even in the absence of insulin.	Norepinephrine	143-156	insulin	Homo sapiens	0-7
8670061-3	1996	Insulin increased 2-deoxyglucose (dGlc) uptake progressively at concentrations from 10(-11) to 10(-6) M, with maximal stimulation at 10(-7) M. Noradrenaline concentrations ranging from 10(-8) to 10(-6) M also enhanced dGlc uptake, even in the absence of insulin.	Norepinephrine	143-156	insulin	Homo sapiens	254-261
8670061-7	1996	Furthermore Western blot analysis with an anti-phosphotyrosine antibody revealed that, in contrast with insulin, noradrenaline apparently does not stimulate intracellular phosphorylation of tyrosine, suggesting that the noradrenaline-induced increase in dGlc uptake depends on elevation of the intracellular cyclic AMP level and not on the signal chain common to insulin.	Norepinephrine	220-233	insulin	Homo sapiens	363-370
8723982-4	1996	RESULTS: Systolic and diastolic blood pressure (SBP and DBP, respectively) were positively related to body mass index, abdomen:hip ratio, norepinephrine excretion, and insulin levels in univariate analyses.	Norepinephrine	138-152	D-box binding PAR bZIP transcription factor	Homo sapiens	56-59
8723982-5	1996	The relationship between insulin level and SBP and DBP persisted after adjustment for body mass index, abdomen:hip ratio, norepinephrine, age, smoking, physical activity level, and antihypertensive medication use.	Norepinephrine	122-136	D-box binding PAR bZIP transcription factor	Homo sapiens	51-54
8723982-6	1996	The norepinephrine level was related to SBP and DBP after adjustment for insulin level, age, smoking, physical activity level, and antihypertensive medication use, and these relationships remained marginally significant after further adjustment for body mass index and abdomen:hip ratio.	Norepinephrine	4-18	D-box binding PAR bZIP transcription factor	Homo sapiens	48-51
8723982-6	1996	The norepinephrine level was related to SBP and DBP after adjustment for insulin level, age, smoking, physical activity level, and antihypertensive medication use, and these relationships remained marginally significant after further adjustment for body mass index and abdomen:hip ratio.	Norepinephrine	4-18	insulin	Homo sapiens	73-80
8723982-9	1996	In a multiple logistic regression model, insulin level, norepinephrine level, and an interaction term for insulin level with norepinephrine excretion were independent predictors of hypertension.	Norepinephrine	125-139	insulin	Homo sapiens	106-113
8813249-1	1996	The purpose of the present investigation was to ascertain the functional significance of the reduction in cyclic AMP (cAMP) levels in the inhibitory action of neuropeptide Y (NPY) on [3H]noradrenaline ([3H]NA) release, as well as to further characterize the subtype(s) of NPY receptors involved in the peptide"s actions in the rat vas deferens.	Norepinephrine	187-200	neuropeptide Y	Rattus norvegicus	159-173
8813249-1	1996	The purpose of the present investigation was to ascertain the functional significance of the reduction in cyclic AMP (cAMP) levels in the inhibitory action of neuropeptide Y (NPY) on [3H]noradrenaline ([3H]NA) release, as well as to further characterize the subtype(s) of NPY receptors involved in the peptide"s actions in the rat vas deferens.	Norepinephrine	187-200	neuropeptide Y	Rattus norvegicus	175-178
9011616-16	1996	IL-1 beta (10 micrograms kg-1)-induced increases in plasma noradrenaline (NA) were suppressed in intact rats pretreated with DEX (0.5 mg kg-1).	Norepinephrine	59-72	interleukin 1 beta	Rattus norvegicus	0-9
8779882-6	1996	Plasma norepinephrine and adrenocorticotropic hormone concentrations were increased after IL-1 beta injection.	Norepinephrine	7-21	interleukin 1 beta	Rattus norvegicus	90-99
8682599-4	1996	However, in saphenous vein contracted with endothelin-1, the responsiveness to nitrovasodilators was significantly blunted (for sodium nitroprusside: 52.33% +/- 5.19%) than that of rings contracted with noradrenaline (for sodium nitroprusside: 95.04% +/- 1.94%).	Norepinephrine	203-216	endothelin 1	Homo sapiens	43-55
8692287-6	1996	In addition to its direct vasoconstricting effects NPY also lowered the noradrenaline EC50 but did not appreciably affect maximal noradrenaline responses indicating possible potentiation.	Norepinephrine	72-85	neuropeptide Y	Rattus norvegicus	51-54
8692288-5	1996	In Session II, venoconstrictor dose-response curves to six doses (0.1-33.33 ng min-1) of (-)noradrenaline acid tartrate were established at congestion pressures 30 and 45 mmHg.	Norepinephrine	92-119	CD59 molecule (CD59 blood group)	Homo sapiens	79-84
8917909-2	1996	Generally, in anestrous ewes beta-endorphin and/or corticoliberin significantly change extracellular concentrations of monoamine metabolites in the MBH-ME, but in estrous ewes both beta-endorphin and CRF alters also dopamine, noradrenaline and serotonin levels.	Norepinephrine	226-239	proopiomelanocortin	Homo sapiens	29-43
8917909-2	1996	Generally, in anestrous ewes beta-endorphin and/or corticoliberin significantly change extracellular concentrations of monoamine metabolites in the MBH-ME, but in estrous ewes both beta-endorphin and CRF alters also dopamine, noradrenaline and serotonin levels.	Norepinephrine	226-239	proopiomelanocortin	Homo sapiens	181-195
8788498-7	1996	Interestingly, the behavioral and biochemical effects of 5-HT2A receptor activation are modulated by activity at other 5-HT receptor subtypes (5-HT1A), as well as by stimulation of receptors for other neurotransmitters and hormones such as norepinephrine (beta-adrenergic) and melatonin.	Norepinephrine	240-254	5-hydroxytryptamine receptor 2A	Homo sapiens	57-72
8789391-15	1996	When rings of saphenous vein without endothelium were incubated with lipopolysaccharide (LPS) (100 micrograms ml-1) or interleukin-1 beta (10 u ml-1) the concentration-contraction curve to noradrenaline was not affected.	Norepinephrine	189-202	interleukin 1 beta	Canis lupus familiaris	119-137
8867778-7	1996	We hypothesize that CGRP might provide a counter-regulatory mechanism to the sympathetic vasoconstrictor transmitters noradrenaline (NA) and neuropeptide Y (NPY) during sympathetic activation.	Norepinephrine	118-131	calcitonin related polypeptide alpha	Homo sapiens	20-24
8717160-14	1996	Combined inhibition of both MAO and COMT was highly effective in reducing the pulmonary clearance of noradrenaline and dopamine, but produced only minor decreases in the total-body clearance of all three catecholamines.	Norepinephrine	101-114	catechol O-methyltransferase	Oryctolagus cuniculus	36-40
9085352-3	1996	Isolated perfused segments of the cat superior mesenteric artery in vitro did not exhibit a vascular response in the resting state, however, ST-induced vasodilatation was observed with norepinephrine preconstriction.	Norepinephrine	185-199	somatostatin	Rattus norvegicus	141-143
8741743-0	1995	Noradrenaline release in hypothalamus and ACTH secretion induced by central interleukin-1beta.	Norepinephrine	0-13	interleukin 1 beta	Rattus norvegicus	76-93
8741743-3	1995	IL-1beta induced an early increase in noradrenaline (NA) release in the paraventricular nucleus (PVN) followed by a second long-lasting enhancement starting from 80 min, with a maximum at 140 min (187 +/- 14%).	Norepinephrine	38-51	interleukin 1 beta	Rattus norvegicus	0-8
8682064-8	1995	A study in 804 men with congestive heart failure who received either enalapril or hydralazine plus isosorbide dinitrate showed the greatest reduction in mortality after 2 years in enalapril treated patients with plasma noradrenaline levels > 900 pg.ml-1 or plasma renin levels > 16 ng.ml-1.h-1.	Norepinephrine	219-232	renin	Homo sapiens	267-272
8554738-0	1995	Sodium ions attenuate the inhibitory effects of neuropeptide Y on norepinephrine release in rat hypothalamus.	Norepinephrine	66-80	neuropeptide Y	Rattus norvegicus	48-62
8554738-3	1995	In an in vitro study, NPY significantly inhibited the stimulation-evoked norepinephrine release from hypothalamic slices in a dose-dependent manner.	Norepinephrine	73-87	neuropeptide Y	Rattus norvegicus	22-25
8554738-6	1995	The blockade of alpha 2-adrenergic receptors by RX 781094 diminished the inhibitory effects of NPY on norepinephrine release.	Norepinephrine	102-116	neuropeptide Y	Rattus norvegicus	95-98
8554738-7	1995	Pretreatment of slices with pertussis toxin (a potent inhibitor of the Gi-proteins) significantly attenuated the suppressive effects of NPY and UK 14,304 on norepinephrine release.	Norepinephrine	157-171	neuropeptide Y	Rattus norvegicus	136-139
8554738-8	1995	When the sodium concentration of the perfusion medium was increased, the inhibitory effects of NPY and UK 14,304 on norepinephrine release were significantly reduced.	Norepinephrine	116-130	neuropeptide Y	Rattus norvegicus	95-98
8554738-9	1995	These results show that NPY might inhibit norepinephrine release that is partially mediated by alpha 2-adrenergic receptors and the pertussis toxin-sensitive Gi-proteins in rat hypothalamus.	Norepinephrine	42-56	neuropeptide Y	Rattus norvegicus	24-27
8554738-10	1995	Moreover, less suppressive effects of NPY and UK 14,304 on norepinephrine release in the presence of excess sodium ions suggest that sodium ions might actively participate in regulating the NPY and alpha 2-adrenergic receptor mediated functions in the central nervous system.	Norepinephrine	59-73	neuropeptide Y	Rattus norvegicus	38-41
8579958-0	1995	Regulation of plasma osteocalcin by corticosterone and norepinephrine during restraint stress.	Norepinephrine	55-69	bone gamma-carboxyglutamate protein	Rattus norvegicus	21-32
8590992-13	1995	Thus these findings support the view that noradrenaline released from cardiac sympathetic nerve terminals exerts a trophic effect on myocardial cells and demonstrates that in vivo, this trophic effect can be reduced by beta 1-adrenoceptor blockade.	Norepinephrine	42-55	adrenoceptor beta 1	Rattus norvegicus	219-238
8549062-9	1995	The effect of SR 49059 was specific to vascular vasopressin receptors as noradrenaline-induced contraction was not influenced by SR 49059.	Norepinephrine	73-86	arginine vasopressin	Homo sapiens	48-59
7591009-7	1995	Plasma vasopressin tended to increase, its levels being inversely correlated with those of posttreatment norepinephrine (r = -.48 P < .03).	Norepinephrine	105-119	arginine vasopressin	Homo sapiens	7-18
8637180-1	1995	Neuropeptide Y (NPY) and ATP are considered cotransmitters with norepinephrine (NE) in sympathetic neurons innervating some blood vessels, including those of the mesentery.	Norepinephrine	64-78	neuropeptide Y	Rattus norvegicus	0-14
8637180-1	1995	Neuropeptide Y (NPY) and ATP are considered cotransmitters with norepinephrine (NE) in sympathetic neurons innervating some blood vessels, including those of the mesentery.	Norepinephrine	64-78	neuropeptide Y	Rattus norvegicus	16-19
8633189-7	1995	The CD4/CD8 ratio and plasma norepinephrine were positively correlated (rs = 0.57, p = 0.037) and the major part of this correlation was due to a correlation between plasma norepinephrine and the percentage of CD4+ cells.	Norepinephrine	173-187	CD4 molecule	Homo sapiens	4-7
8633189-7	1995	The CD4/CD8 ratio and plasma norepinephrine were positively correlated (rs = 0.57, p = 0.037) and the major part of this correlation was due to a correlation between plasma norepinephrine and the percentage of CD4+ cells.	Norepinephrine	173-187	CD4 molecule	Homo sapiens	210-213
7664655-2	1995	Alterations in norepinephrine (NE) release, reuptake, and metabolism in the hypothalamic paraventricular nucleus (PVN) could also contribute to dysregulation of the HPA axis in obese Zucker rats via effects on corticotropin-releasing hormone neurons or could be secondary to some other primary defect.	Norepinephrine	15-29	corticotropin releasing hormone	Rattus norvegicus	210-241
7500004-1	1995	Transport of norepinephrine (NE+) by cocaine- and antidepressant-sensitive transporters in presynaptic terminals is predicted to involve the cotransport of Na+ and Cl-, resulting in a net movement of charge per transport cycle.	Norepinephrine	13-27	solute carrier family 6 member 2	Homo sapiens	184-187
7649571-9	1995	This effect was specific for norepinephrine, because responses to arginine vasopressin were similar in vessels isolated from normotensive and hypertensive rats.	Norepinephrine	29-43	arginine vasopressin	Rattus norvegicus	75-86
8528707-0	1995	Effects of gender on the central actions of neuropeptide Y and norepinephrine on vasopressin and blood pressure in the rat.	Norepinephrine	63-77	arginine vasopressin	Rattus norvegicus	81-92
8528707-9	1995	When NPY and norepinephrine were given together, the pattern of the vasopressin response was similar to that of norepinephrine alone.	Norepinephrine	13-27	arginine vasopressin	Rattus norvegicus	68-79
8528707-11	1995	In non-proestrous rats, NPY also enhanced the pressor response to norepinephrine.	Norepinephrine	66-80	neuropeptide Y	Rattus norvegicus	24-27
8528707-12	1995	Thus, NPY interacts centrally with norepinephrine in vasopressin release and cardiovascular function and this effect is dependent upon gender and phase of the estrous cycle.	Norepinephrine	35-49	neuropeptide Y	Rattus norvegicus	6-9
8528707-12	1995	Thus, NPY interacts centrally with norepinephrine in vasopressin release and cardiovascular function and this effect is dependent upon gender and phase of the estrous cycle.	Norepinephrine	35-49	arginine vasopressin	Rattus norvegicus	53-64
7475986-10	1995	In addition TNF-alpha infused rats had raised norepinephrine levels.	Norepinephrine	46-60	tumor necrosis factor	Rattus norvegicus	12-21
7675822-0	1995	Noradrenaline and dopamine infusions modulate arachidonic acid cyclooxygenase and 5-lipoxygenase pathways ex vivo in man.	Norepinephrine	0-13	arachidonate 5-lipoxygenase	Homo sapiens	82-96
7540174-5	1995	In contrast, whole cell recordings made directly from transfected beta TC3 cells expressing GIRK1-cp revealed inwardly rectifying, pertussis toxin-sensitive currents activated by norepinephrine and galanin.	Norepinephrine	179-193	potassium inwardly-rectifying channel, subfamily J, member 3	Mus musculus	92-97
8529037-1	1995	Close relations exist between the peripheral dopaminergic system, and the sympathetic nervous and renin-angiotensin-aldosterone system: D1 dopamine receptor stimulation-induced vasodilation may activate the sympathetic nervous and renin-angiotensin system in vivo, presynaptic D2 dopamine receptor stimulation is known to inhibit stimulated norepinephrine release from sympathetic nerve terminals, in experimental conditions both in vitro and in vivo.	Norepinephrine	341-355	renin	Homo sapiens	98-103
7665810-1	1995	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of dopamine and norepinephrine, and therefore is of significant interest as a candidate gene in studies of affective disorders.	Norepinephrine	87-101	tyrosine hydroxylase	Homo sapiens	0-20
7665810-1	1995	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of dopamine and norepinephrine, and therefore is of significant interest as a candidate gene in studies of affective disorders.	Norepinephrine	87-101	tyrosine hydroxylase	Homo sapiens	22-24
7671996-4	1995	[Sar9,Met(O2)11]substance P (3 nM) did not affect either high-K+ or noradrenaline-induced contraction, while CGRP (3 nM) significantly reduced the noradrenaline-induced motor response.	Norepinephrine	147-160	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	109-113
7623275-0	1995	Release of Ca2+ by noradrenaline and ATP from the same Ca2+ store sensitive to both InsP3 and Ca2+ in rat portal vein myocytes.	Norepinephrine	19-32	carbonic anhydrase 2	Rattus norvegicus	11-14
7623275-0	1995	Release of Ca2+ by noradrenaline and ATP from the same Ca2+ store sensitive to both InsP3 and Ca2+ in rat portal vein myocytes.	Norepinephrine	19-32	carbonic anhydrase 2	Rattus norvegicus	55-58
7623275-0	1995	Release of Ca2+ by noradrenaline and ATP from the same Ca2+ store sensitive to both InsP3 and Ca2+ in rat portal vein myocytes.	Norepinephrine	19-32	carbonic anhydrase 2	Rattus norvegicus	55-58
7623275-2	1995	Changes in cytosolic free Ca2+ concentration ([Ca2+]i) induced by noradrenaline (NA) and ATP were investigated using indo-1 microspectrofluorimetry in single smooth muscle cells of rat portal vein.	Norepinephrine	66-79	carbonic anhydrase 2	Rattus norvegicus	26-29
7623275-2	1995	Changes in cytosolic free Ca2+ concentration ([Ca2+]i) induced by noradrenaline (NA) and ATP were investigated using indo-1 microspectrofluorimetry in single smooth muscle cells of rat portal vein.	Norepinephrine	66-79	carbonic anhydrase 2	Rattus norvegicus	47-50
7538196-2	1995	In the present study, we show that VIP (5-200 nM) treatment increased the intracellular calcium concentration ([Ca2+]i) in 64% of isolated individual pinealocytes; in comparison, norepinephrine (NE) elevated [Ca2+]i in 93% of the cells and produced more robust responses.	Norepinephrine	179-193	vasoactive intestinal peptide	Homo sapiens	35-38
8574778-1	1995	Atrial natriuretic factor (ANF) effects on neuronal norepinephrine (NE) release evoked by angiotensin II (ANG II) or angiotensin III (ANG III) were studied in the rat adrenal medulla.	Norepinephrine	52-66	angiotensinogen	Rattus norvegicus	90-104
8574778-1	1995	Atrial natriuretic factor (ANF) effects on neuronal norepinephrine (NE) release evoked by angiotensin II (ANG II) or angiotensin III (ANG III) were studied in the rat adrenal medulla.	Norepinephrine	52-66	angiotensinogen	Rattus norvegicus	106-112
7796988-4	1995	Contractile responses to noradrenaline were reduced after incubation in 1 mU/ml of insulin for 20 min (p < 0.01; Group 1).	Norepinephrine	25-38	insulin	Homo sapiens	83-90
7796988-5	1995	Increasing concentrations of insulin were found to reduce the contractile response to noradrenaline in a dose-dependent manner (Group 2; 0.1 mU/ml by 8% [p < 0.01], 1 mU/ml by 17% [p < 0.02] and 10 mU/ml by 22% [p < 0.01]).	Norepinephrine	86-99	insulin	Homo sapiens	29-36
7721432-0	1995	Insulin attenuates norepinephrine-induced venoconstriction.	Norepinephrine	19-33	insulin	Homo sapiens	0-7
7721432-10	1995	Incremental doses of insulin, when combined with the maximum dose of norepinephrine, caused highly reproducible dose-dependent increases in mean venous diameter (P < .001) compared with norepinephrine alone.	Norepinephrine	189-203	insulin	Homo sapiens	21-28
7639097-0	1995	Early postnatal appearance of enhanced noradrenaline content in the brain of vasopressin-deficient Brattleboro rat; normal adrenoceptor densities and aberrant influences of vasopressin treatment.	Norepinephrine	39-52	arginine vasopressin	Rattus norvegicus	77-88
7630433-0	1995	Inhibition by interleukin-1 beta of noradrenaline release in rat spleen: involvement of lymphocytes, NO and opioid receptors.	Norepinephrine	36-49	interleukin 1 beta	Rattus norvegicus	14-32
7630433-1	1995	Effects of indomethacin, N omega-nitro-L-arginine (NNA) and naloxone, and of pretreatment with cyclophosphamide (CY), on the interleukin (IL)-1 beta induced inhibition of exocytotic noradrenaline release were investigated in the isolated, vascularly perfused spleen of the rat.	Norepinephrine	182-195	interleukin 1 beta	Rattus norvegicus	125-148
7630433-3	1995	Perfusion of the spleen with Tyrode"s solution containing IL-1 beta (100 pg/ml) for 90 min caused an inhibition of the stimulation-evoked noradrenaline overflow which persisted for at least 20 min after washout of the IL.	Norepinephrine	138-151	interleukin 1 beta	Rattus norvegicus	58-67
9453523-8	1998	Among patients with cardioinhibitory syncope, norepinephrine concentration rose significantly from baseline to syncope (0.44 +/- 0.12 ng/ml versus 1.14 +/- 0.72 ng/ml; p < 0.05), whereas no significant change was observed in epinephrine (0.08 +/- 0.03 ng/ml versus 2.74 +/- 2.85 ng/ml; p = not significant [NS]), renin (5.68 +/- 3.03 pg/ml versus 19.58 +/- 11.47 pg/ml; p = NS), or aldosterone concentration (66.60 +/- 16.10 ng/ml versus 109.00 +/- 44.70 ng/ml; p = NS).	Norepinephrine	46-60	renin	Homo sapiens	316-321
9453523-9	1998	Patients with vasodepressor syncope had a significant rise in renin (9.03 +/- 4.56 pg/ml versus 52.53 +/- 41.63 pg/ml; p < 0.05) and aldosterone concentration (95.43 +/- 103.03 ng/ml versus 249.57 +/- 191.54 ng/ml; p < 0.05), whereas no change in level of epinephrine (0.12 +/- 0.12 ng/ml versus 0.28 +/- 0.33 ng/ml; p = NS) or norepinephrine (0.60 +/- 0.26 ng/ml versus 0.86 +/- 0.53 ng/ml; p = NS) was detected.	Norepinephrine	334-348	renin	Homo sapiens	62-67
9421421-1	1998	c-Fos/c-Jun dimers (activating protein-1 transcription factor) are involved in the modulatory actions of angiotensin II (Ang II) on brain norepinephrine neurons, effects mediated via Ang II type 1 (AT1) receptors.	Norepinephrine	138-152	angiotensinogen	Rattus norvegicus	105-119
9421421-1	1998	c-Fos/c-Jun dimers (activating protein-1 transcription factor) are involved in the modulatory actions of angiotensin II (Ang II) on brain norepinephrine neurons, effects mediated via Ang II type 1 (AT1) receptors.	Norepinephrine	138-152	angiotensinogen	Rattus norvegicus	121-127
9595449-9	1998	In human prostate tissue (excised during cystectomy in bladder cancer patients), ET-1 and in most cases, the ETB agonist sarafotoxin 6c (S6c) caused contractions of similar magnitude but more sustained than that of norepinephrine (10(-6) mol/L).	Norepinephrine	215-229	endothelin 1	Homo sapiens	81-85
9595449-9	1998	In human prostate tissue (excised during cystectomy in bladder cancer patients), ET-1 and in most cases, the ETB agonist sarafotoxin 6c (S6c) caused contractions of similar magnitude but more sustained than that of norepinephrine (10(-6) mol/L).	Norepinephrine	215-229	endothelin receptor type B	Homo sapiens	109-112
9422390-2	1998	Raf-1-dependent activation of mitogen-activated protein kinase (MAPK) is the key in the chronic norepinephrine neuromodulatory actions of Ang II and is associated with the translocation of MAPK into the nucleus.	Norepinephrine	96-110	angiotensinogen	Homo sapiens	138-144
9564614-6	1998	Deprenyl, but especially methylamphetamine pre-treatment can prevent the noradrenaline release induced by the noradrenergic neurotoxin DSP-4.	Norepinephrine	73-86	dual specificity phosphatase 26	Homo sapiens	135-140
9928902-1	1998	The norepinephrine transporter (NET) plays a critical role in brain norepinephrine homeostasis and is a target for antidepressants and drugs of abuse.	Norepinephrine	4-18	solute carrier family 6 member 2	Homo sapiens	32-35
9440482-7	1998	Concomitant GH and prednisolone administration increased REE (2,068 +/- 85, P +/- .05) and leptin (4.82 +/- 0.93, P +/- .05), had no effect on either epinephrine or norepinephrine, and decreased FT3 (5.0 +/- 0.2, P < .05).	Norepinephrine	165-179	growth hormone 1	Homo sapiens	12-14
9405459-8	1997	Since a subpressor dose of Ang II did not increase GRK5 mRNA levels and norepinephrine infusion also increased GRK5 mRNA expression, we conclude that Ang II-induced GRK5 up-regulation in rat aortas may be due to hypertension per se.	Norepinephrine	72-86	angiotensinogen	Rattus norvegicus	150-156
9537817-5	1997	Suppressor doses of endothelin-1 (3 x 10(-10) M) or sarafotoxin S6c (S6c) (3 x 10(-10) M) potentiated significantly the norepinephrine-induced vasoconstriction, in the same preparation.	Norepinephrine	120-134	endothelin 1	Rattus norvegicus	20-32
9537817-6	1997	Moreover, supernatant-induced enhancement of pressor responses to norepinephrine was markedly suppressed by TGF-beta1 neutralizing antibody.	Norepinephrine	66-80	transforming growth factor, beta 1	Rattus norvegicus	108-117
9537817-7	1997	Transforming growth factor-beta1 (TGF-beta1) (40 pM) also significantly enhanced the pressor responses to norepinephrine (10(-6) M) and this enhancement was significantly inhibited by phosphoramidon.	Norepinephrine	106-120	transforming growth factor, beta 1	Rattus norvegicus	0-32
9537817-7	1997	Transforming growth factor-beta1 (TGF-beta1) (40 pM) also significantly enhanced the pressor responses to norepinephrine (10(-6) M) and this enhancement was significantly inhibited by phosphoramidon.	Norepinephrine	106-120	transforming growth factor, beta 1	Rattus norvegicus	34-43
9537817-8	1997	These results suggest that platelet-derived TGF-beta1 stimulates the vascular production of endothelin-1 and thereby enhances vasoconstrictor responses to norepinephrine.	Norepinephrine	155-169	transforming growth factor, beta 1	Rattus norvegicus	44-53
9537817-8	1997	These results suggest that platelet-derived TGF-beta1 stimulates the vascular production of endothelin-1 and thereby enhances vasoconstrictor responses to norepinephrine.	Norepinephrine	155-169	endothelin 1	Rattus norvegicus	92-104
9451469-14	1997	It appears that essential hypertension and type 2 diabetes are connected with or may be the result of a reduction in synthesis of the intracellular messenger cyclic PIP, whose synthesis is stimulated by hormones like insulin and noradrenaline (alpha-adrenergic action).	Norepinephrine	229-242	prolactin induced protein	Rattus norvegicus	165-168
9389517-2	1997	The UCP gene is under the control of norepinephrine (NE) via cAMP.	Norepinephrine	37-51	uncoupling protein 1	Rattus norvegicus	4-7
9439541-1	1997	It has previously been shown that in normal subjects, physiological elevation of norepinephrine (NE) impairs insulin sensitivity (Si) but does not influence insulin secretion.	Norepinephrine	81-95	insulin	Homo sapiens	109-116
9458508-6	1997	Noradrenaline and ATP seem to act as transmitter substances in the transposed vas segments because the results show a reduction of the contraction after pretreatment with prazosin or chi, beta-methylene ATP.	Norepinephrine	0-13	arginine vasopressin	Rattus norvegicus	78-81
9386112-4	1997	Vasopressin (0.1 U/min) increased mean arterial pressure (57+/-4 to 84+/-2 mm Hg, P<.001) and systemic vascular resistance (813+/-113 to 1188+/-87 dyne-s/cm5, P<.001), with decreased norepinephrine administration.	Norepinephrine	189-203	arginine vasopressin	Homo sapiens	0-11
9386112-5	1997	There was no significant response to saline, but in three subjects who crossed over, blinded vasopressin increased mean arterial pressure (69+/-8 to 93+/-4 mm Hg) and systemic vascular resistance (898+/-88 to 1443+/-72 dyne-s/cm5) with decreased norepinephrine administration.	Norepinephrine	246-260	arginine vasopressin	Homo sapiens	93-104
9383175-1	1997	OBJECTIVE: To investigate the role of angiotensin converting enzyme (ACE) inhibition in bradykinin-mediated modulation of noradrenaline release in human and rat atrium.	Norepinephrine	122-135	angiotensin I converting enzyme	Homo sapiens	38-67
9383175-1	1997	OBJECTIVE: To investigate the role of angiotensin converting enzyme (ACE) inhibition in bradykinin-mediated modulation of noradrenaline release in human and rat atrium.	Norepinephrine	122-135	angiotensin I converting enzyme	Homo sapiens	69-72
9383175-1	1997	OBJECTIVE: To investigate the role of angiotensin converting enzyme (ACE) inhibition in bradykinin-mediated modulation of noradrenaline release in human and rat atrium.	Norepinephrine	122-135	kininogen 1	Homo sapiens	88-98
9383175-5	1997	In contrast, 0.001-0.1 micromol/l bradykinin enhanced the release of noradrenaline in rat atrium.	Norepinephrine	69-82	kininogen 1	Homo sapiens	34-44
9383175-6	1997	In the presence of 3 micromol/l of the ACE inhibitor captopril, however, bradykinin significantly enhanced the release of noradrenaline in human atrium.	Norepinephrine	122-135	kininogen 1	Homo sapiens	73-83
9399334-7	1997	These results confirm the existence of prejunctional angiotensin II receptors at the vascular neuroeffector junction that facilitate release of norepinephrine.	Norepinephrine	144-158	angiotensinogen	Rattus norvegicus	53-67
9408006-4	1997	Neuropeptide Y, even in subspasmogenic concentrations, potentiated contractions evoked by acetylcholine, guanethidine and noradrenaline.	Norepinephrine	122-135	neuropeptide Y	Rattus norvegicus	0-14
9408006-7	1997	Neuropeptide Y (> 10 nM) caused a concentration-dependent potentiation of electrical field stimulation-evoked contraction alone, matching its potentiation of noradrenaline-evoked contraction.	Norepinephrine	161-174	neuropeptide Y	Rattus norvegicus	0-14
9351498-2	1997	The aim of the present study was to investigate in rat mesenteric artery rings whether low concentrations of vasopressin could modify the contractile responses to noradrenaline and electrical stimulation of perivascular nerves.	Norepinephrine	163-176	arginine vasopressin	Rattus norvegicus	109-120
9351498-8	1997	Vasopressin (3 x 10[-10] and 10[-9] M) caused concentration-dependent potentiation of the contractions elicited by electrical stimulation (2-8 Hz; 0.2 ms duration for 30 s) and produced leftward shifts of the concentration-response curve for noradrenaline.	Norepinephrine	242-255	arginine vasopressin	Rattus norvegicus	0-11
9351498-13	1997	In artery rings contracted by 10(-6) M noradrenaline in the presence of 10(-6) M guanethidine and 10(-6) M atropine, electrical stimulation (2, 4 and 8 Hz) produced frequency-dependent relaxations which were unaffected by 10(-9) M vasopressin but abolished by 10(-6) M tetrodotoxin.	Norepinephrine	39-52	arginine vasopressin	Rattus norvegicus	231-242
9357451-1	1997	Tumor necrosis factor-alpha (TNF alpha) and the alpha 2-adrenergic agonist clonidine regulate norepinephrine (NE) release from noradrenergic nerve terminals in the central nervous system (CNS).	Norepinephrine	94-108	tumor necrosis factor	Rattus norvegicus	0-27
9357451-1	1997	Tumor necrosis factor-alpha (TNF alpha) and the alpha 2-adrenergic agonist clonidine regulate norepinephrine (NE) release from noradrenergic nerve terminals in the central nervous system (CNS).	Norepinephrine	94-108	tumor necrosis factor	Rattus norvegicus	29-38
9350634-12	1997	In response to insulin infusion, catecholamines increased on day 2 (noradrenaline and adrenaline) and day 7 (adrenaline), but not at sea level.	Norepinephrine	68-81	insulin	Homo sapiens	15-22
9334989-6	1997	In sham rats phenylephrine (80 nmol) into MnPO increased, whereas norepinephrine (80 nmol) and clonidine (40 nmol) reduced ANG II-induced water intake while sodium intake was reduced only by clonidine into MnPO.	Norepinephrine	66-80	angiotensinogen	Rattus norvegicus	123-129
9334989-8	1997	In lesioned rats ANG II-induced sodium intake was reduced by phenylephrine and noradrenaline, whereas clonidine produced no change.	Norepinephrine	79-92	angiotensinogen	Rattus norvegicus	17-23
9381945-2	1997	It is still under debate whether angiotensin II facilitates noradrenaline release in the heart.	Norepinephrine	60-73	angiotensinogen	Homo sapiens	33-47
9389931-3	1997	Dexamethasone and noradrenaline suppressed secretion of IL-2, IFN alpha, IFN gamma, TNF alpha, IL-1 alpha and IL-1 beta.	Norepinephrine	18-31	interleukin 2	Homo sapiens	56-60
9389931-3	1997	Dexamethasone and noradrenaline suppressed secretion of IL-2, IFN alpha, IFN gamma, TNF alpha, IL-1 alpha and IL-1 beta.	Norepinephrine	18-31	interferon alpha 1	Homo sapiens	62-71
9389931-3	1997	Dexamethasone and noradrenaline suppressed secretion of IL-2, IFN alpha, IFN gamma, TNF alpha, IL-1 alpha and IL-1 beta.	Norepinephrine	18-31	interferon gamma	Homo sapiens	73-82
9389931-3	1997	Dexamethasone and noradrenaline suppressed secretion of IL-2, IFN alpha, IFN gamma, TNF alpha, IL-1 alpha and IL-1 beta.	Norepinephrine	18-31	tumor necrosis factor	Homo sapiens	84-93
9389931-3	1997	Dexamethasone and noradrenaline suppressed secretion of IL-2, IFN alpha, IFN gamma, TNF alpha, IL-1 alpha and IL-1 beta.	Norepinephrine	18-31	interleukin 1 beta	Homo sapiens	110-119
9389931-5	1997	Suppression of cytokine secretion by TGF-beta 1 was further intensified significantly and dose dependently by addition of noradrenaline.	Norepinephrine	122-135	transforming growth factor beta 1	Homo sapiens	37-47
9334910-6	1997	The reactivity to noradrenaline was tested by cumulative application (10(-9) to 3 x 10(-4) M) before and after a single concentration of neuropeptide Y (NPY).	Norepinephrine	18-31	neuropeptide Y	Rattus norvegicus	137-151
9334910-6	1997	The reactivity to noradrenaline was tested by cumulative application (10(-9) to 3 x 10(-4) M) before and after a single concentration of neuropeptide Y (NPY).	Norepinephrine	18-31	neuropeptide Y	Rattus norvegicus	153-156
9334910-8	1997	The effect of noradrenaline after NPY was unchanged in renal vessels of control rats, whereas it was diminished in intrarenal vessels for both diabetic and control rats.	Norepinephrine	14-27	neuropeptide Y	Rattus norvegicus	34-37
9334910-12	1997	NPY decreased the contractile response to noradrenaline.	Norepinephrine	42-55	neuropeptide Y	Rattus norvegicus	0-3
9282927-0	1997	Stimulation of the sympathetic perimesenteric arterial nerves releases neuropeptide Y potentiating the vasomotor activity of noradrenaline: involvement of neuropeptide Y-Y1 receptors.	Norepinephrine	125-138	neuropeptide Y	Rattus norvegicus	71-85
9282927-0	1997	Stimulation of the sympathetic perimesenteric arterial nerves releases neuropeptide Y potentiating the vasomotor activity of noradrenaline: involvement of neuropeptide Y-Y1 receptors.	Norepinephrine	125-138	neuropeptide Y	Rattus norvegicus	155-169
9303577-9	1997	In summary, in the epididymal portion of SHR vas deferens, the increased maximum contractile response to noradrenaline is due to an increase of Em.	Norepinephrine	105-118	arginine vasopressin	Rattus norvegicus	45-48
9277562-7	1997	Nor-epinephrine (NE), in the dose range 10(-6)-10(-4) M, significantly increased the IL-6 levels in the rat spleen lymphocyte culture media.	Norepinephrine	0-15	interleukin 6	Rattus norvegicus	85-89
9269538-7	1997	In central neurons PKC appears to be tonically active and its inhibition results in a decrease in noradrenaline release under most, if not all, conditions.	Norepinephrine	98-111	proline rich transmembrane protein 2	Homo sapiens	19-22
9269538-13	1997	Activation of PKC by phorbol esters produces a large enhancement in action potential-evoked noradrenaline release in both the central nervous system and in peripheral tissues.	Norepinephrine	92-105	proline rich transmembrane protein 2	Homo sapiens	14-17
9269636-10	1997	The results also show that the doses of noradrenaline required to increase the basal mean arterial blood pressure by 10 mmHg (262 +/- 38 vs 150 +/- 25 ng/kg/min; P < 0.05) and by 20 mmHg (431 +/- 36 vs 250 +/- 38 ng/kg/ min; P < 0.05) respectively, were significantly higher during the insulin infusion than during the time-control experiment.	Norepinephrine	40-53	insulin	Homo sapiens	292-299
9269636-13	1997	Moreover, insulin attenuates the cardiovascular reactivity to a graded noradrenaline infusion, suggesting that insulin causes vasodilatation in healthy man.	Norepinephrine	71-84	insulin	Homo sapiens	10-17
9269636-13	1997	Moreover, insulin attenuates the cardiovascular reactivity to a graded noradrenaline infusion, suggesting that insulin causes vasodilatation in healthy man.	Norepinephrine	71-84	insulin	Homo sapiens	111-118
9251973-4	1997	In VMH-lesioned rats ANG II-induced water intake increased with a previous injection of noradrenaline, phenylephrine, or isoproterenol.	Norepinephrine	88-101	angiotensinogen	Rattus norvegicus	21-27
9223197-6	1997	RESULTS: The CPT 1 given before anesthetic administration resulted in an increase in heart rate, mean arterial pressure, cardiac index, and plasma concentrations of norepinephrine and epinephrine.	Norepinephrine	165-179	carnitine palmitoyltransferase 1A	Homo sapiens	13-18
9507567-6	1997	Angiotensin II, a receptor agonist, and caffeine, a Ca(2+)-induced Ca2+ releaser, elevated [Ca2+]i in the same manner but was more potent than KCl and norepinephrine.	Norepinephrine	151-165	angiotensinogen	Rattus norvegicus	0-14
9194512-0	1997	Human brain natriuretic peptide reduces blood pressure in normotensive and acute norepinephrine-induced hypertensive rabbits.	Norepinephrine	81-95	natriuretic peptide B	Canis lupus familiaris	6-31
9187779-2	1997	Intrathecal fentanyl (ITF) provides effective labour analgesia but its effect on maternal epinephrine (Epi) and norepinephrine (NE) concentrations is not known.	Norepinephrine	112-126	trefoil factor 3	Homo sapiens	22-25
9180639-4	1997	L-arginine (1 x 10(-3) mol/L), reversed the prevention produced by N omega-nitro-L-arginine methyl ester on the increased release of norepinephrine caused by Ang II and Ang-(1-7).	Norepinephrine	133-147	angiotensinogen	Rattus norvegicus	158-164
9200561-3	1997	Human CGRP at concentrations greater than 3 nM reduced the contractile responses to exogenous noradrenaline and ATP.	Norepinephrine	94-107	calcitonin related polypeptide alpha	Homo sapiens	6-10
9135928-6	1997	Plasma norepinephrine levels were significantly higher on glibenclamide (6.41 +/- 1.77 vs. 4.26 +/- 1.54 mmol/l, P < 0.01), and systolic BP responses to intravenous norepinephrine and angiotensin II were significantly higher on glibenclamide than on metformin (P < 0.02 and P < 0.05, respectively).	Norepinephrine	7-21	angiotensinogen	Homo sapiens	187-201
9135945-10	1997	The expectations of the insulin injection increased the norepinephrine levels and the heart rate.	Norepinephrine	56-70	insulin	Homo sapiens	24-31
9228469-5	1997	The concentration of CgA in the patients with non-metastatic pheochromocytoma was significantly correlated with that of plasma norepinephrine (P < 0.005, r = 0.68) and urinary norepinephrine (P < 0.05, r = 0.65), but not with that of epinephrine.	Norepinephrine	127-141	chromogranin A	Homo sapiens	21-24
9228469-5	1997	The concentration of CgA in the patients with non-metastatic pheochromocytoma was significantly correlated with that of plasma norepinephrine (P < 0.005, r = 0.68) and urinary norepinephrine (P < 0.05, r = 0.65), but not with that of epinephrine.	Norepinephrine	179-193	chromogranin A	Homo sapiens	21-24
9104846-1	1997	Endothelin-1 (ET-1) is an endothelium-derived potent vasoconstrictor peptide that potentiates contractions to norepinephrine in human vessels.	Norepinephrine	110-124	endothelin 1	Homo sapiens	0-12
9104846-1	1997	Endothelin-1 (ET-1) is an endothelium-derived potent vasoconstrictor peptide that potentiates contractions to norepinephrine in human vessels.	Norepinephrine	110-124	endothelin 1	Homo sapiens	14-18
9104846-12	1997	Therefore, the present study demonstrates the possibility that the increase in production of ET-1 in nonworking muscles may cause vasoconstriction and hence decrease blood flow in nonworking muscles through its direct vasoconstrictive action or through an indirect effect of ET-1 to enhance vasoconstrictions to norepinephrine and that these responses may be helpful in increasing blood flow in working muscles.	Norepinephrine	312-326	endothelin 1	Homo sapiens	93-97
9234080-0	1997	Profiles of the response to noradrenaline in the whole and bisected rat vas deferens.	Norepinephrine	28-41	arginine vasopressin	Rattus norvegicus	72-75
9234080-2	1997	The present study was carried out to look at the differences between the whole and bisected rat vas deferens in response to cumulative and non-cumulative administration of noradrenaline in terms of sensitivity and maximum response.	Norepinephrine	172-185	arginine vasopressin	Rattus norvegicus	96-99
9234080-5	1997	The sensitivity, as measured by the -log EC50 value for noradrenaline, was significantly lower in the prostatic portion than in the whole vas deferens and epididymal portion.	Norepinephrine	56-69	arginine vasopressin	Rattus norvegicus	138-141
9234080-6	1997	The maximum contractions reached by the epididymal and the prostatic half were 65.03 +/- 10.43% and 13.84 +/- 5.28% of the maximal contraction evoked by noradrenaline in the whole rat vas deferens.	Norepinephrine	153-166	arginine vasopressin	Rattus norvegicus	184-187
9234080-17	1997	In conclusion, our evaluation of the parameters of the mechanical response of the whole and bisected vas deferens to noradrenaline rationalize the, often contradictory, findings of the current literature.	Norepinephrine	117-130	arginine vasopressin	Rattus norvegicus	101-104
9124549-3	1997	The objective of this study was to test the hypothesis that a modest physiological increase in plasma AVP would potentiate the responses of heart rate (HR), forearm vascular resistance (FVR), plasma norepinephrine (NE), or systemic NE spillover to baroreflex unloading and loading after pretreatment with lisinopril in healthy human volunteers.	Norepinephrine	199-213	arginine vasopressin	Homo sapiens	102-105
9218207-8	1997	The molecular effect of ACE inhibitors on the ischaemic heart is less well known but seems to be related to a reduction in noradrenaline release or to an improvement in bradykinin; the effect is thus complementary to that of calcium antagonists.	Norepinephrine	123-136	angiotensin I converting enzyme	Homo sapiens	24-27
9091308-1	1997	PDGF-AB and TGF-beta 1 intervene in molluscan stress response, the former inhibiting and the latter inducing the release of norepinephrine and epinephrine from hemocytes.	Norepinephrine	124-138	transforming growth factor beta 1	Homo sapiens	12-22
9091308-5	1997	After pre-incubation with PDGF-AB or TGF-beta 1 in the presence of CRH or ACTH, norepinephrine and epinephrine release falls.	Norepinephrine	80-94	transforming growth factor beta 1	Homo sapiens	37-47
9058422-0	1997	Effects of area postrema lesion and abdominal vagotomy on interleukin-1 beta-induced norepinephrine release in the hypothalamic paraventricular nucleus region in the rat.	Norepinephrine	85-99	interleukin 1 beta	Rattus norvegicus	58-76
9058422-1	1997	Peripherally administered interleukin-1 beta (IL-1 beta) has been shown to increase extracellular norepinephrine (NE) concentration in the paraventricular nucleus (PVN) of the hypothalamus.	Norepinephrine	98-112	interleukin 1 beta	Rattus norvegicus	26-44
9058422-1	1997	Peripherally administered interleukin-1 beta (IL-1 beta) has been shown to increase extracellular norepinephrine (NE) concentration in the paraventricular nucleus (PVN) of the hypothalamus.	Norepinephrine	98-112	interleukin 1 beta	Rattus norvegicus	46-55
9032464-2	1997	Addition of noradrenaline led to an enhancement of LPL gene expression; the mRNA levels increased as a linear function of time for at least 5 h and were finally approx.	Norepinephrine	12-25	lipoprotein lipase	Rattus norvegicus	51-54
9032464-9	1997	An increase in LPL mRNA level similar to (but not significantly exceeding) that caused by noradrenaline could also be induced by the cAMP-elevating agents forskolin and cholera toxin, and 8-Br-cAMP also increased LPL mRNA levels.	Norepinephrine	90-103	lipoprotein lipase	Rattus norvegicus	15-18
9469791-4	1997	The hyperinsulinemic (fasting insulin > or = mean + 2SD in normotensive) subjects had higher plasma norepinephrine levels in all blood pressure groups than did nonhyperinsulinemic (< mean + 2SD) subjects (normotensives P < 0.05, BHT P < 0.01, and EHT P < 0.05).	Norepinephrine	103-117	insulin	Homo sapiens	9-16
9038987-3	1997	The elevation of plasma norepinephrine and epinephrine induced by immobilization stress was also suppressed by central ANG II-receptor blockade, suggesting a general attenuation of stress-induced sympathetic nervous and adrenomedullary activity by central ANG II-receptor blockade.	Norepinephrine	24-38	angiotensinogen	Rattus norvegicus	119-125
9038987-3	1997	The elevation of plasma norepinephrine and epinephrine induced by immobilization stress was also suppressed by central ANG II-receptor blockade, suggesting a general attenuation of stress-induced sympathetic nervous and adrenomedullary activity by central ANG II-receptor blockade.	Norepinephrine	24-38	angiotensinogen	Rattus norvegicus	256-262
9288827-7	1997	These results indicate that beta-endorphin acts on mu-opioid receptors to inhibit K+-evoked norepinephrine release from A2 neurons and suggest that the receptors involved are not located on noradrenergic nerve terminals.	Norepinephrine	92-106	proopiomelanocortin	Homo sapiens	28-42
9170549-6	1997	Recent studies of the hyperadrenergic (elevated plasma norepinephrine) subgroup of orthostatic intolerance is documenting a clinical spectrum including attenuated plasma renin activity and aldosterone, reduced supine blood volume coupled with dynamic orthostatic hypovolemia, elevated plasma norepinephrine and epinephrine, impaired clearance of norepinephrine from the circulation and evidence of partial dysautonomia.	Norepinephrine	55-69	renin	Homo sapiens	170-175
9187048-0	1997	Effect of angiotensin II on the reactivity of isolated mesenteric vessels to norepinephrine in rats poisoned with cadmium.	Norepinephrine	77-91	angiotensinogen	Rattus norvegicus	10-24
9187048-8	1997	Nifedipine (100 ng/ml), infused together with angiotensin II, inhibited pressor response to norepinephrine in preparation from both control and cadmium treated rats, to 60.5% and 69.3%, respectively.	Norepinephrine	92-106	angiotensinogen	Rattus norvegicus	46-60
9132617-12	1997	The finding that norepinephrine stimulates activated astrocytes to produce IL-6 implies that the cytokine cascade may be activated by neuronal processes under certain conditions.	Norepinephrine	17-31	interleukin 6	Homo sapiens	75-79
9016908-20	1996	Antidepressant-like effects of the noradrenaline uptake inhibitors seem, on the other hand, to be mediated by postsynaptic 5-HT1A receptors.	Norepinephrine	35-48	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	123-129
8988485-9	1996	Fenoterol (1-1000 nM), a beta 2-adrenoceptor agonist, and angiotensin II (1-1000 nM) significantly increased noradrenaline release in a concentration-dependent manner.	Norepinephrine	109-122	angiotensinogen	Homo sapiens	25-72
8934559-2	1996	NPY exerts vasoconstrictor action together with noradrenalin and has been found to inhibit the release of neurotransmitters from primary afferent fibers.	Norepinephrine	48-60	neuropeptide Y	Rattus norvegicus	0-3
8982101-5	1996	Under bacteria-rich conditions, norepinephrine (Emax = 10(-6) M, p = 0.012) and isoproterenol (Emax = 10(-6) M, p = 0.048) concentration-dependently inhibited IL-6 secretion from murine spleen slices in contrast to bacteria-free conditions.	Norepinephrine	32-46	interleukin 6	Mus musculus	159-163
9001201-11	1996	Results of treatment with the locus coeruleus neurotoxin DSP-4 established that axonal transport accounts for delivery of both triiodothyronine and norepinephrine from locus coeruleus to noradrenergic terminal fields.	Norepinephrine	148-162	dual specificity phosphatase 26	Homo sapiens	57-62
8939965-0	1996	Calcium/calmodulin-dependent protein kinase IIalpha mediates activation of mitogen-activated protein kinase and cytosolic phospholipase A2 in norepinephrine-induced arachidonic acid release in rabbit aortic smooth muscle cells.	Norepinephrine	142-156	calcium/calmodulin-dependent protein kinase type II subunit alpha	Oryctolagus cuniculus	0-51
8945753-2	1996	Cerebral NPY content was changed by drugs influencing endogenous norepinephrine (NE) in rats.	Norepinephrine	65-79	neuropeptide Y	Rattus norvegicus	9-12
8922747-16	1996	Rather, combinations of 0.1 microM angiotensin II and PD 123319 (both 0.01 and 0.1 microM) enhanced S-I [3H]-noradrenaline efflux, whereas 0.1 microM angiotensin II alone was without effect.	Norepinephrine	109-122	angiotensinogen	Rattus norvegicus	35-49
8922747-19	1996	The present findings indicate that in the caudal artery of WKY and SH rats, and as previously found in Sprague-Dawley preparations, angiotensin II receptors similar to the AT1B subtype subserve enhancement of transmitter noradrenaline release.	Norepinephrine	221-234	angiotensinogen	Rattus norvegicus	132-146
8922747-19	1996	The present findings indicate that in the caudal artery of WKY and SH rats, and as previously found in Sprague-Dawley preparations, angiotensin II receptors similar to the AT1B subtype subserve enhancement of transmitter noradrenaline release.	Norepinephrine	221-234	angiotensin II receptor, type 1b	Rattus norvegicus	172-176
8922747-21	1996	As previously suggested for Sprague-Dawley caudal artery preparations, the synergistic prejunctional interaction of losartan and 0.1 microM angiotensin II in caudal artery preparations from WKY rats may be due to either the unmasking by losartan of a latent population of angiotensin II receptors subserving facilitation of transmitter noradrenaline release, or blockade by losartan of an inhibitory action of angiotensin II on transmitter release.	Norepinephrine	336-349	angiotensinogen	Rattus norvegicus	140-154
8922748-16	1996	The findings confirm our previous suggestion that, in the rat caudal artery, angiotensin II receptors similar to the AT1B subtype subserve enhancement of transmitter noradrenaline release.	Norepinephrine	166-179	angiotensinogen	Rattus norvegicus	77-91
8922748-16	1996	The findings confirm our previous suggestion that, in the rat caudal artery, angiotensin II receptors similar to the AT1B subtype subserve enhancement of transmitter noradrenaline release.	Norepinephrine	166-179	angiotensin II receptor, type 1b	Rattus norvegicus	117-121
8922748-18	1996	The synergistic prejunctional interaction of 0.01 microM losartan and 0.1 microM angiotensin II may be due to either the unmasking by losartan of a latent population of angiotensin II receptors also subserving facilitation of transmitter noradrenaline release, or alternatively, losartan may block an inhibitory action of angiotensin II on transmitter noradrenaline release which normally opposes its facilitatory effect.	Norepinephrine	238-251	angiotensinogen	Rattus norvegicus	81-95
8922748-18	1996	The synergistic prejunctional interaction of 0.01 microM losartan and 0.1 microM angiotensin II may be due to either the unmasking by losartan of a latent population of angiotensin II receptors also subserving facilitation of transmitter noradrenaline release, or alternatively, losartan may block an inhibitory action of angiotensin II on transmitter noradrenaline release which normally opposes its facilitatory effect.	Norepinephrine	352-365	angiotensinogen	Rattus norvegicus	81-95
8958787-2	1996	It has been recently reported that noradrenaline (NA), applied within the hypothalamic paraventricular nucleus, suppresses the pulsatile release of LH in the rat through a corticotrophin-releasing hormone (CRH)-dependent mechanism.	Norepinephrine	35-48	corticotropin releasing hormone	Rattus norvegicus	172-204
8958787-2	1996	It has been recently reported that noradrenaline (NA), applied within the hypothalamic paraventricular nucleus, suppresses the pulsatile release of LH in the rat through a corticotrophin-releasing hormone (CRH)-dependent mechanism.	Norepinephrine	35-48	corticotropin releasing hormone	Rattus norvegicus	206-209
8951980-2	1996	This inhibition appears to be due to cocaine-induced indirect stimulation of the inhibitory serotonergic 5-HT1A and noradrenergic alpha 2 receptors via the inhibition of reuptake of synaptic serotonin (5-HT) and norepinephrine (NE), respectively.	Norepinephrine	212-226	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	105-111
8946653-1	1996	Lipopolysaccharide (LPS)-induced hypotension and impaired aortic contraction to norepinephrine (NE) are thought to be consequent to induction of nitric oxide synthase (iNOS).	Norepinephrine	80-94	nitric oxide synthase 2	Rattus norvegicus	168-172
8906519-8	1996	ACE inhibition led to increased plasma noradrenaline at rest but not during mental stress in hypertensive patients.	Norepinephrine	39-52	angiotensin I converting enzyme	Homo sapiens	0-3
8912225-4	1996	Five incremental doses of noradrenaline acid tartrate (0.33-33.33 ng min-1) were infused twice in each subject: first with 5-min washout (5% dextrose saline) periods in between ("noncumulative dose-response curve"), then without interspersed washout periods ("cumulative dose-response curve").	Norepinephrine	26-53	CD59 molecule (CD59 blood group)	Homo sapiens	69-74
8783676-10	1996	Peak norepinephrine and peak ANP also positively correlated with respective resting values of norepinephrine (r = 0.58 pg/mL, P < 0.05) and ANP (r = 0.94, P < 0.01).	Norepinephrine	5-19	natriuretic peptide A	Homo sapiens	143-146
8783676-10	1996	Peak norepinephrine and peak ANP also positively correlated with respective resting values of norepinephrine (r = 0.58 pg/mL, P < 0.05) and ANP (r = 0.94, P < 0.01).	Norepinephrine	94-108	natriuretic peptide A	Homo sapiens	29-32
8853359-6	1996	Contrastingly, a large dose-dependent decrease in reactivity to norepinephrine was found immediately after exposure to IL-1 beta and still persisted 100 min after the end of the exposure.	Norepinephrine	64-78	interleukin 1 beta	Rattus norvegicus	119-128
8853359-10	1996	2) Short exposure to IL-1 beta but not to rhTNF or IL-6 diminishes the response of the arterioles to norepinephrine but not to KCl.	Norepinephrine	101-115	interleukin 1 beta	Rattus norvegicus	21-30
8843757-5	1996	A positive correlation was observed between peak plasma epinephrine or norepinephrine and IL-6 levels at 15 min.	Norepinephrine	71-85	interleukin 6	Homo sapiens	90-94
8784081-5	1996	IFN alpha induced increases in plasma concentrations of norepinephrine (225 +/- 93%; P < 0.02 vs. control), epinephrine (272 +/- 80%; P < 0.05), cortisol (353 +/- 63%; P < 0.02), glucagon (50 +/- 12%; P < 0.05), free fatty acids (223 +/- 61%; P < 0.02), and glycerol (68 +/- 21%; P < 0.02) and in resting energy expenditure (36 +/- 50%; P < 0.03).	Norepinephrine	56-70	interferon alpha 1	Homo sapiens	0-9
8707386-0	1996	Angiotensin II increases norepinephrine turnover in the anteroventral third ventricle of spontaneously hypertensive rats.	Norepinephrine	25-39	angiotensinogen	Rattus norvegicus	0-14
8707386-1	1996	We evaluated the effect of angiotensin II (Ang II) administered by intracerebroventricular injection on norepinephrine turnover in the anteroventral third ventricle in adult spontaneously hypertensive rats (SHR, n = 35) and age-matched Wistar-Kyoto rats (WKY, n = 38).	Norepinephrine	104-118	angiotensinogen	Rattus norvegicus	27-41
8707386-1	1996	We evaluated the effect of angiotensin II (Ang II) administered by intracerebroventricular injection on norepinephrine turnover in the anteroventral third ventricle in adult spontaneously hypertensive rats (SHR, n = 35) and age-matched Wistar-Kyoto rats (WKY, n = 38).	Norepinephrine	104-118	angiotensinogen	Rattus norvegicus	43-49
8678641-7	1996	Interleukin-6 correlated with duration of extracorporeal circulation, dose of norepinephrine and epinephrine support, pulmonary capillary wedge pressure, mean pulmonary arterial pressure, right atrial pressure, heart rate, cardiac index, and inversely with systemic vascular resistance.	Norepinephrine	78-92	interleukin 6	Homo sapiens	0-13
8994995-6	1996	In both studies, vascular function as tested in the aortic vessels was improved not only after high- but also after low-dose ACE inhibitor treatment: an inhibition of vascular ACE was associated with attenuated vasoconstrictor responses to norepinephrine and enhanced dilator responses to acetylcholine and bradykinin.	Norepinephrine	240-254	angiotensin I converting enzyme	Rattus norvegicus	125-128
8994995-6	1996	In both studies, vascular function as tested in the aortic vessels was improved not only after high- but also after low-dose ACE inhibitor treatment: an inhibition of vascular ACE was associated with attenuated vasoconstrictor responses to norepinephrine and enhanced dilator responses to acetylcholine and bradykinin.	Norepinephrine	240-254	angiotensin I converting enzyme	Rattus norvegicus	176-179
8762104-16	1996	Contractions of the vas deferens induced by exogenous ATP and noradrenaline were not affected by GABA (0.1-100 microM).	Norepinephrine	62-75	arginine vasopressin	Rattus norvegicus	20-23
8800565-14	1996	CGRP may limit noradrenaline-induced constriction of cerebral vessels and contribute to dilatation during hypotension (autoregulation), reactive hyperaemia, seizures and cortical spreading depression.	Norepinephrine	15-28	calcitonin related polypeptide alpha	Homo sapiens	0-4
8681492-1	1996	BACKGROUND: One suggested mechanism for the reduction in mortality rates resulting from the use of angiotensin converting enzyme inhibitors in congestive heart failure is the inhibition of the angiotensin II-mediated norepinephrine release.	Norepinephrine	217-231	angiotensin I converting enzyme	Homo sapiens	99-128
8681492-1	1996	BACKGROUND: One suggested mechanism for the reduction in mortality rates resulting from the use of angiotensin converting enzyme inhibitors in congestive heart failure is the inhibition of the angiotensin II-mediated norepinephrine release.	Norepinephrine	217-231	angiotensinogen	Homo sapiens	193-207
8636570-3	1996	Neuropeptide Y inhibits the release of norepinephrine at the presynaptic level and can be considered to act as a neuromodulator.	Norepinephrine	39-53	neuropeptide Y	Rattus norvegicus	0-14
8636570-9	1996	RESULTS: The concentration of norepinephrine measured in the samples was decreased by 50% with neuropeptide Y in 2- and 4-week old rats after infarction, but by only 20% (p < 0.05) in 8-week old rats after infraction.	Norepinephrine	30-44	neuropeptide Y	Rattus norvegicus	95-109
8636570-10	1996	The diminished inhibitory effects of neuropeptide Y on norepinephrine release was associated with increased sympathetic activity, as reflected by plasma norepinephrine; 8-week old rats after infarction had almost a 100% (p < 0.05) increase in their plasma norepinephrine level compared with the sham group.	Norepinephrine	55-69	neuropeptide Y	Rattus norvegicus	37-51
8636570-10	1996	The diminished inhibitory effects of neuropeptide Y on norepinephrine release was associated with increased sympathetic activity, as reflected by plasma norepinephrine; 8-week old rats after infarction had almost a 100% (p < 0.05) increase in their plasma norepinephrine level compared with the sham group.	Norepinephrine	153-167	neuropeptide Y	Rattus norvegicus	37-51
8636570-10	1996	The diminished inhibitory effects of neuropeptide Y on norepinephrine release was associated with increased sympathetic activity, as reflected by plasma norepinephrine; 8-week old rats after infarction had almost a 100% (p < 0.05) increase in their plasma norepinephrine level compared with the sham group.	Norepinephrine	153-167	neuropeptide Y	Rattus norvegicus	37-51
8636570-12	1996	CONCLUSIONS: The data presented in this report suggest that the reduction of the inhibitory activation of neuropeptide Y on sympathetic release may contribute to elevated norepinephrine levels after myocardial infarction.	Norepinephrine	171-185	neuropeptide Y	Rattus norvegicus	106-120
8973087-6	1996	Initial elevation and steady decline of IL-6 concentrations were seen after surgical injury, and this response related significantly to post-operative norepinephrine and glucagon levels throughout the study period, and to insulin levels only at the end of surgery.	Norepinephrine	151-165	interleukin 6	Homo sapiens	40-44
8973087-9	1996	CONCLUSIONS: Initial elevation of IL-6 concentration might induce stress hormones such as norepinephrine and glucagon, but not insulin after surgical trauma.	Norepinephrine	90-104	interleukin 6	Homo sapiens	34-38
8829134-0	1996	Neuropeptide Y perfused in the preoptic area of rats shifts extracellular efflux of dopamine, norepinephrine, and serotonin during hypothermia and feeding.	Norepinephrine	94-108	neuropeptide Y	Rattus norvegicus	0-14
8631897-2	1996	Induction of the promoter by transforming growth factor beta or norepinephrine requires serum response factor (SRF) and TEF-1; expression is inhibited by YY1.	Norepinephrine	64-78	TEA domain transcription factor 1	Homo sapiens	120-125
8631897-2	1996	Induction of the promoter by transforming growth factor beta or norepinephrine requires serum response factor (SRF) and TEF-1; expression is inhibited by YY1.	Norepinephrine	64-78	YY1 transcription factor	Homo sapiens	154-157
8967449-10	1996	The inhibitory effects of norepinephrine were abolished by depletion of intracellular Ca2+ stores.	Norepinephrine	26-40	carbonic anhydrase 2	Rattus norvegicus	86-89
8737076-3	1996	Dopamine, noradrenaline and adrenaline enter the red blood cell by a similar process, which shows saturation kinetics with Vmax values of 0.54 +/- 0.12, 0.48 +/- 0.08 and 0.63 +/- 0.13 mumol (1 cells)-1 min-1, respectively, and K(m) values of 15.62 +/- 1.19, 5.81 +/- 1.19 and 12.00 +/- 2.97 nM, respectively.	Norepinephrine	10-23	CD59 molecule (CD59 blood group)	Homo sapiens	203-208
8621214-3	1996	A decrease in plasma norepinephrine (from 208 +/- 74 to 142 +/- 52 pg/mL, P < .01) was associated with decreases in plasma renin activity (from 1.06 +/- 0.98 to 0.62 +/- 0.63 ng/mL per hour, P < .01) and serum aldosterone (from 70 +/- 28 to 57 +/- 24 pg/mL, P < .05).	Norepinephrine	21-35	renin	Homo sapiens	126-131
8780041-0	1996	Changes of neuropeptide Y messenger RNA and peptide by drugs influencing endogenous norepinephrine content in cerebrocortex of the rat.	Norepinephrine	84-98	neuropeptide Y	Rattus norvegicus	11-25
8842867-10	1996	The EFS-evoked [3H]-noradrenaline (NA) release was significantly greater in TGR than in SD rats.	Norepinephrine	20-33	thioredoxin reductase 3	Mus musculus	76-79
8636125-3	1996	Rab3A and Rab3B both targeted to norepinephrine (NE)-containing large dense core vesicles (LDCVs) when stably expressed in PC12 cells, as determined by immunofluorescence and membrane fractionation.	Norepinephrine	33-47	RAB3A, member RAS oncogene family	Rattus norvegicus	0-5
11862256-5	1996	With the ACE inhibitors, this effect is related to changes in the levels of circulating angiotensin II and noradrenaline rather than to improved hemodynamics.	Norepinephrine	107-120	angiotensin I converting enzyme	Homo sapiens	9-12
8593708-1	1996	Mediators involved in ischemia preconditioning such as adenosine and norepinephrine, can activate protein kinase C (PKC), and a variety of observations suggest that both PKC and ATP-sensitive K+ current (I (KATP) play essential roles in ischemic preconditioning.	Norepinephrine	69-83	proline rich transmembrane protein 2	Homo sapiens	98-114
8593708-1	1996	Mediators involved in ischemia preconditioning such as adenosine and norepinephrine, can activate protein kinase C (PKC), and a variety of observations suggest that both PKC and ATP-sensitive K+ current (I (KATP) play essential roles in ischemic preconditioning.	Norepinephrine	69-83	proline rich transmembrane protein 2	Homo sapiens	116-119
8593708-1	1996	Mediators involved in ischemia preconditioning such as adenosine and norepinephrine, can activate protein kinase C (PKC), and a variety of observations suggest that both PKC and ATP-sensitive K+ current (I (KATP) play essential roles in ischemic preconditioning.	Norepinephrine	69-83	proline rich transmembrane protein 2	Homo sapiens	170-173
8813249-0	1996	Neuropeptide Y inhibits 3[H]noradrenaline release in the rat vas deferens independently of cAMP levels.	Norepinephrine	28-41	neuropeptide Y	Rattus norvegicus	0-14
8660292-4	1996	Injection of noradrenaline into pups at thermoneutrality (36 degrees C) led to increases in UCP and LPL gene expression, but noradrenaline injections had no further effect in cold-exposed pups.	Norepinephrine	13-26	uncoupling protein 1	Rattus norvegicus	92-95
8660292-4	1996	Injection of noradrenaline into pups at thermoneutrality (36 degrees C) led to increases in UCP and LPL gene expression, but noradrenaline injections had no further effect in cold-exposed pups.	Norepinephrine	13-26	lipoprotein lipase	Rattus norvegicus	100-103
8904082-3	1996	In the presence of a beta-adrenoceptor antagonist, norepinephrine augmented the effects of neuropeptide Y.	Norepinephrine	51-65	neuropeptide Y	Rattus norvegicus	91-105
8593828-0	1996	Regulation of norepinephrine transport system by angiotensin II in neuronal cultures of normotensive and spontaneously hypertensive rat brains.	Norepinephrine	14-28	angiotensinogen	Rattus norvegicus	49-63
8593828-4	1996	Ang II causes both acute and chronic stimulation of [3H]-norepinephrine (NE) uptake in neuronal cultures of Wistar Kyoto (WKY) rat brain.	Norepinephrine	57-71	angiotensinogen	Rattus norvegicus	0-6
8558260-0	1996	Vasoactive intestinal peptide, pituitary adenylate cyclase-activating peptide, and noradrenaline induce the transcription factors CCAAT/enhancer binding protein (C/EBP)-beta and C/EBP delta in mouse cortical astrocytes: involvement in cAMP-regulated glycogen metabolism.	Norepinephrine	83-96	CCAAT/enhancer binding protein (C/EBP), delta	Mus musculus	178-189
8907725-6	1996	From these results, it seems likely that S-100 protein co-stored all types of B-cell granules involved in the maturation of granules, and AADC, DBH and CgA are related to the synthesis of noradrenaline in crystalloid granules of B-cells.	Norepinephrine	188-201	dopamine beta-hydroxylase	Gallus gallus	144-147
8907725-6	1996	From these results, it seems likely that S-100 protein co-stored all types of B-cell granules involved in the maturation of granules, and AADC, DBH and CgA are related to the synthesis of noradrenaline in crystalloid granules of B-cells.	Norepinephrine	188-201	chromogranin A	Gallus gallus	152-155
8734244-2	1996	The kalaemia which was 3.9 mmol.L-1 at admission in the intensive care unit decreased to 1.3 mmol.L-1 during a perfusion of noradrenaline (0.3 micrograms.kg-1.min-1).	Norepinephrine	124-137	CD59 molecule (CD59 blood group)	Homo sapiens	159-164
8788483-10	1996	In strips of atrial appendages, 5-HT receptor agonists (e.g. 5-HT, 5-CT and sumatriptan) inhibited noradrenaline release at potencies which are correlated with their ki values at 5-HT1D alpha and 5-HT1D beta receptors.	Norepinephrine	99-112	5-hydroxytryptamine receptor 1B	Homo sapiens	196-207
8724644-7	1996	Administration of DSP-4 also produced a marked decrease of noradrenaline (NA) levels in the goldfish brain, seven days later, while dopamine (DA) and serotonin (5-HT) levels were unaffected by toxin injection.	Norepinephrine	59-72	dual specificity phosphatase 26	Homo sapiens	18-23
8724644-9	1996	Noradrenaline levels measured 40 days after toxin administration show that DSP-4 toxicity was completely reversed.	Norepinephrine	0-13	dual specificity phosphatase 26	Homo sapiens	75-80
8825357-9	1996	The P2Y-purinoceptor agonist, 2-methylthio-ATP (1-100 microM) reduced noradrenaline overflow, an effect prevented by the P2-purinoceptor antagonist, cibacron blue 3GA (100 microM) and suramin (100 microM).	Norepinephrine	70-83	purinergic receptor P2Y1	Rattus norvegicus	4-7
8825357-13	1996	The P2Y-purinoceptor antagonist, cibacron blue 3GA (100 microM) increased evoked noradrenaline overflow as did suramin, a non-selective P2-antagonist.	Norepinephrine	81-94	purinergic receptor P2Y1	Rattus norvegicus	4-7
8825357-15	1996	It is concluded that, in rat tail artery, inhibitory (A1 and P2Y) and facilitatory (A2A) purinoceptors are present and modulate noradrenaline release evoked by electrical stimulation.	Norepinephrine	128-141	purinergic receptor P2Y1	Rattus norvegicus	61-64
8594311-0	1996	Internal calcium stores and norepinephrine overflow from isolated, field stimulated rat vas deferens.	Norepinephrine	28-42	arginine vasopressin	Rattus norvegicus	88-91
8594311-1	1996	Ryanodine has been shown to selectively inhibit the initial phase of contraction of rat vas deferens smooth muscle stimulated by endogenous release of norepinephrine (NE) (1), and part of this effect could be pre-junctional.	Norepinephrine	151-165	arginine vasopressin	Rattus norvegicus	88-91
8848453-0	1996	Central DSP-4 treatment decreases norepinephrine levels and courtship behavior in male zebra finches.	Norepinephrine	34-48	dual specificity phosphatase 26	Homo sapiens	8-13
8748684-5	1995	Conversely, at concentrations above 100 muM, salsolinol inhibited the uptake of noradrenaline and dopamine, with IC50 values of 411 muM and 379 muM, respectively.	Norepinephrine	80-93	latexin	Homo sapiens	132-135
8748684-5	1995	Conversely, at concentrations above 100 muM, salsolinol inhibited the uptake of noradrenaline and dopamine, with IC50 values of 411 muM and 379 muM, respectively.	Norepinephrine	80-93	latexin	Homo sapiens	132-135
8605948-5	1995	Similarly, the contraction to noradrenaline was potentiated when applied at the beginning of this fade of levcromakalim-induced relaxation, whereas this response was attenuated in control tissues bathed in 20 mM KCl (in K-PSS).	Norepinephrine	30-43	PSS	Homo sapiens	222-225
7503249-1	1995	Acute elevations in circulating angiotensin II (ANG II) are known to increase circulating norepinephrine (NE) levels.	Norepinephrine	90-104	angiotensinogen	Homo sapiens	32-46
7503249-1	1995	Acute elevations in circulating angiotensin II (ANG II) are known to increase circulating norepinephrine (NE) levels.	Norepinephrine	90-104	angiotensinogen	Homo sapiens	48-54
8703648-12	1995	Both noradrenaline and methoxamine produced dose-dependent venoconstriction: the geometric mean ED50 for noradrenaline was 4.41 ng min-1 and for methoxamine was 2558 ng min-1; the potency ratio (noradrenaline/methoxamine) was 2884.	Norepinephrine	5-18	CD59 molecule (CD59 blood group)	Homo sapiens	131-136
8703648-12	1995	Both noradrenaline and methoxamine produced dose-dependent venoconstriction: the geometric mean ED50 for noradrenaline was 4.41 ng min-1 and for methoxamine was 2558 ng min-1; the potency ratio (noradrenaline/methoxamine) was 2884.	Norepinephrine	5-18	CD59 molecule (CD59 blood group)	Homo sapiens	169-174
8703648-12	1995	Both noradrenaline and methoxamine produced dose-dependent venoconstriction: the geometric mean ED50 for noradrenaline was 4.41 ng min-1 and for methoxamine was 2558 ng min-1; the potency ratio (noradrenaline/methoxamine) was 2884.	Norepinephrine	105-118	CD59 molecule (CD59 blood group)	Homo sapiens	131-136
8703648-12	1995	Both noradrenaline and methoxamine produced dose-dependent venoconstriction: the geometric mean ED50 for noradrenaline was 4.41 ng min-1 and for methoxamine was 2558 ng min-1; the potency ratio (noradrenaline/methoxamine) was 2884.	Norepinephrine	105-118	CD59 molecule (CD59 blood group)	Homo sapiens	131-136
7586371-11	1995	Treatment with ACE inhibitors attenuated the reduction in cardiac output and stroke volume indices and improved the inotropic response to dobutamine and isoprenaline and reversed partially the cardiac norepinephrine content in the CHF rat.	Norepinephrine	201-215	angiotensin I converting enzyme	Rattus norvegicus	15-18
8984125-1	1995	OBJECTIVE: The existence of presynaptic angiotensin II receptors, modulating the release of the sympathetic neurotransmitter norepinephrine, was examined in the perfused human forearm model.	Norepinephrine	125-139	angiotensinogen	Homo sapiens	40-54
8984125-5	1995	In contrast, the spillover of norepinephrine even decreased during angiotensin II administration, both before and during intravenous sodium nitroprusside administration, probably because of angiotensin II-induced forearm vasoconstriction.	Norepinephrine	30-44	angiotensinogen	Homo sapiens	67-81
8984125-5	1995	In contrast, the spillover of norepinephrine even decreased during angiotensin II administration, both before and during intravenous sodium nitroprusside administration, probably because of angiotensin II-induced forearm vasoconstriction.	Norepinephrine	30-44	angiotensinogen	Homo sapiens	190-204
8984125-6	1995	Similar vasoconstrictor doses of angiotensin II and methoxamine produced similar changes in spillover and total plasma appearance rate of norepinephrine.	Norepinephrine	138-152	angiotensinogen	Homo sapiens	33-47
8600482-6	1995	Among dysthymics, ACTH was unrelated to any of the lymphocyte subsets, but norepinephrine was directly related to total lymphocytes, CD3, CD4, and NK cells.	Norepinephrine	75-89	CD4 molecule	Homo sapiens	138-141
8584237-0	1995	The effect of the angiotensin II (AT1A) receptor stably transfected into human neuroblastoma SH-SY5Y cells on noradrenaline release and changes in intracellular calcium.	Norepinephrine	110-123	angiotensinogen	Homo sapiens	18-32
8568924-0	1995	Norepinephrine but not epinephrine stimulates the release of corticotropin-releasing factor from in vitro superfused rat hypothalamus.	Norepinephrine	0-14	corticotropin releasing hormone	Rattus norvegicus	61-91
7562541-5	1995	The NPY-mediated potentiation of the noradrenaline elicited increase in perfusion pressure in the rat mesenteric bed was antagonized with an IC50 value of 976 (542-1760) nM.	Norepinephrine	37-50	neuropeptide Y	Rattus norvegicus	4-7
7476289-1	1995	Infusion of epinephrine and norepinephrine reduces insulin-mediated glucose disposal, ie, induces insulin resistance.	Norepinephrine	28-42	insulin	Homo sapiens	51-58
7476289-1	1995	Infusion of epinephrine and norepinephrine reduces insulin-mediated glucose disposal, ie, induces insulin resistance.	Norepinephrine	28-42	insulin	Homo sapiens	98-105
8709678-6	1995	Thus, it has been experimentally proven that CDP-choline increases noradrenaline and dopamine levels in the CNS.	Norepinephrine	67-80	natriuretic peptide A	Homo sapiens	45-48
7573551-8	1995	Norepinephrine increased UCP mRNA levels in denervated BAT of both lean and obese rats and decreased beta 3-AR mRNA in lean rats but not obese rats.	Norepinephrine	0-14	uncoupling protein 1	Rattus norvegicus	25-28
8582385-10	1995	Impairment of left ventricular systolic function was confirmed in 38 of the 50 symptomatic patients (76%) and was associated with increases in plasma concentrations of active renin (58 +/- 8 IU.mol-1, P < 0.001 compared to healthy elderly subjects), angiotensin II (23 +/- 5 pg.ml-1, P < 0.008), noradrenaline (7.7 +/- 1.2 nmol.l-1, P < 0.01) and atrial natriuretic peptide (121 +/- 18 pg.ml-1, P < 0.002).	Norepinephrine	302-315	renin	Homo sapiens	175-180
7474668-0	1995	Erythropoietin enhances vascular responsiveness to norepinephrine in renal failure.	Norepinephrine	51-65	erythropoietin	Homo sapiens	0-14
7496795-3	1995	This microdialysis study examined whether NPY can modulate rat PVN noradrenaline release in vivo, as has been shown in vitro.	Norepinephrine	67-80	neuropeptide Y	Rattus norvegicus	42-45
7496795-8	1995	This raises the possibility that NPY may potentiate rather than inhibit brain noradrenaline release in vivo.	Norepinephrine	78-91	neuropeptide Y	Rattus norvegicus	33-36
8542306-0	1995	Intracerebroventricular administration of neuropeptide Y inhibits release of noradrenaline in the hypothalamic paraventricular nucleus caused by manual restraint in the rat through an opioid system.	Norepinephrine	77-90	neuropeptide Y	Rattus norvegicus	42-56
7592197-9	1995	Comparable doses of angiotensin II (n = 5) and norepinephrine (n = 5) microinjected into the endothelin-1 sensitive area also did not influence respiratory output.	Norepinephrine	47-61	endothelin 1	Homo sapiens	93-105
7616202-2	1995	We previously generated transgenic mice expressing phenylethanolamine N-methyltransferase (PNMT) under the control of a human dopamine beta-hydroxylase gene promoter to switch catecholamine specificity from the norepinephrine phenotype to the epinephrine phenotype.	Norepinephrine	211-225	phenylethanolamine-N-methyltransferase	Mus musculus	51-89
7616202-2	1995	We previously generated transgenic mice expressing phenylethanolamine N-methyltransferase (PNMT) under the control of a human dopamine beta-hydroxylase gene promoter to switch catecholamine specificity from the norepinephrine phenotype to the epinephrine phenotype.	Norepinephrine	211-225	phenylethanolamine-N-methyltransferase	Mus musculus	91-95
7616202-4	1995	In the transgenic target tissues, a high-level expression of PNMT led to a dramatic increase in the epinephrine levels, whereas the norepinephrine levels were decreased to 48.6-87.9% of the nontransgenic control levels.	Norepinephrine	132-146	phenylethanolamine-N-methyltransferase	Mus musculus	61-65
7636761-8	1995	The sensitivity and the maximal relaxation induced by SNP in veins contracted with ET-1 (0.2 microM) was significantly diminished (in comparison with norepinephrine; 10 microM).	Norepinephrine	150-164	endothelin 1	Homo sapiens	83-87
7582398-1	1995	Increasing animal evidence support an important facilitatory interaction between angiotensin II and norepinephrine within the kidney.	Norepinephrine	100-114	angiotensinogen	Homo sapiens	81-95
7611494-3	1995	Des-Asp1-angiotensin I, angiotensin I, II, and III produced similar increases in perfusion pressure and were approximately 300-fold more potent than (p-amino-Phe6)-angiotensin II, 100-fold more potent than angiotensin IV, 30-fold more potent than norepinephrine, and 10-fold more potent than U-46619.	Norepinephrine	247-261	angiotensinogen	Homo sapiens	9-22
7611494-3	1995	Des-Asp1-angiotensin I, angiotensin I, II, and III produced similar increases in perfusion pressure and were approximately 300-fold more potent than (p-amino-Phe6)-angiotensin II, 100-fold more potent than angiotensin IV, 30-fold more potent than norepinephrine, and 10-fold more potent than U-46619.	Norepinephrine	247-261	angiotensinogen	Homo sapiens	24-37
8529037-1	1995	Close relations exist between the peripheral dopaminergic system, and the sympathetic nervous and renin-angiotensin-aldosterone system: D1 dopamine receptor stimulation-induced vasodilation may activate the sympathetic nervous and renin-angiotensin system in vivo, presynaptic D2 dopamine receptor stimulation is known to inhibit stimulated norepinephrine release from sympathetic nerve terminals, in experimental conditions both in vitro and in vivo.	Norepinephrine	341-355	renin	Homo sapiens	231-236
7594427-5	1995	In the mature rats blood pressure was elevated in the Ang II-infused rats above that in the untreated and noradrenaline-infused groups, in which blood pressure was not significantly different.	Norepinephrine	106-119	angiotensinogen	Rattus norvegicus	54-60
7648260-2	1995	In the WKY rat, Ang II promoted a dose-dependent increase in the IC50 value of l-noradrenaline when competing for ([3H]p-aminoclonidine ([3H]PAC) binding sites, which reached a maximum of 400% with 10 nM of Ang II and was associated with a small decrease in the B0 value (20%).	Norepinephrine	79-94	angiotensinogen	Rattus norvegicus	16-22
7648260-2	1995	In the WKY rat, Ang II promoted a dose-dependent increase in the IC50 value of l-noradrenaline when competing for ([3H]p-aminoclonidine ([3H]PAC) binding sites, which reached a maximum of 400% with 10 nM of Ang II and was associated with a small decrease in the B0 value (20%).	Norepinephrine	79-94	angiotensinogen	Rattus norvegicus	207-213
7648260-6	1995	The cardiovascular analysis showed that a threshold dose of Ang II (0.05 pmol) counteracted the vasodepressor effect produced by l-noradrenaline coinjected in the NTS of the WKY rat.	Norepinephrine	129-144	angiotensinogen	Rattus norvegicus	60-66
7625922-10	1995	EPO treatment induced a significant decrease in somatotropin, prolactin, follitropin, lutropin, ACTH, cortisol, plasma renin activity, aldosterone, noradrenaline, adrenaline, dopamine, glucagon, pancreatic polypeptide, and gastrin plasma levels and an increase in plasma insulin, estradiol, testosterone, atrial natriuretic peptide, thyrotropin, and thyroxine.	Norepinephrine	148-161	erythropoietin	Homo sapiens	0-3
7650844-7	1995	30 mM of caffeine, 5 microM of norepinephrine or 10 microM of IP3 resulted in greater increases in the rates of Ca2+ efflux in WKY than in SHR aortic strips.	Norepinephrine	31-45	carbonic anhydrase 2	Rattus norvegicus	112-115
7643911-7	1995	These findings suggest that stimulation of beta-adrenoceptors enhance noradrenaline release from rat cerebral cortical, hypothalamic and hippocampal slices; this release mechanism appears to involve both beta 1- and beta 2-adrenoceptor subtypes.	Norepinephrine	70-83	adrenoceptor beta 1	Rattus norvegicus	204-235
7733239-0	1995	Norepinephrine and ANG II stimulate secretion of TGF-beta by neonatal rat cardiac fibroblasts in vitro.	Norepinephrine	0-14	transforming growth factor, beta 1	Rattus norvegicus	49-57
7733239-4	1995	Angiotensin II (ANG II) and norepinephrine (NE) each augmented up to threefold the expression and secretion of latent TGF-beta 1 and TGF-beta 2 and also induced a shift in isoform predominance from beta 1 to beta 2.	Norepinephrine	28-42	transforming growth factor, beta 1	Rattus norvegicus	118-128
7721403-1	1995	Angiotensin II (Ang II) potentiates sympathetic neurotransmission by presynaptic facilitation of norepinephrine release.	Norepinephrine	97-111	angiotensinogen	Homo sapiens	0-22
7652508-4	1995	In animals pretreated with both estradiol benzoate and progesterone, exogenous A II stimulated the release of LH; (2) Brain endogenous A II may be involved in the preovulatory release of LH on proestrus; (3) A II affects LH secretion via LH-RH and norepinephrine in the brain.	Norepinephrine	248-262	angiotensinogen	Homo sapiens	79-83
7652508-4	1995	In animals pretreated with both estradiol benzoate and progesterone, exogenous A II stimulated the release of LH; (2) Brain endogenous A II may be involved in the preovulatory release of LH on proestrus; (3) A II affects LH secretion via LH-RH and norepinephrine in the brain.	Norepinephrine	248-262	angiotensinogen	Homo sapiens	135-139
7652508-4	1995	In animals pretreated with both estradiol benzoate and progesterone, exogenous A II stimulated the release of LH; (2) Brain endogenous A II may be involved in the preovulatory release of LH on proestrus; (3) A II affects LH secretion via LH-RH and norepinephrine in the brain.	Norepinephrine	248-262	angiotensinogen	Homo sapiens	135-139
7887963-2	1995	In aortic rings precontracted with 0.3 microM norepinephrine PTHrP(1-34) caused a dose-dependent relaxation with the maximal response of 33% being observed at 10(-6) M. PTHrP was nearly equipotent to PTH or CGRP in the vasodilatory action.	Norepinephrine	46-60	parathyroid hormone	Rattus norvegicus	61-64
8540766-8	1995	[Val5]-Angiotensin II was more potent than [Ile5]-Angiotensin II insofar as plasma noradrenaline increased significantly (p < 0.05) following doses of 0.75 and 7.5 micrograms/kg b.w.	Norepinephrine	83-96	angiotensinogen	Rattus norvegicus	7-21
9489621-14	1998	7 In conclusion, the alpha1A-adrenoceptor mediated contraction to noradrenaline of the rat prostatic vas deferens appears to consist of an initial phasic component due to the release of intracellular Ca2+ from ryanodine-sensitive stores.	Norepinephrine	66-79	arginine vasopressin	Rattus norvegicus	101-104
7721195-6	1995	A subthreshold concentration of endothelin-1 potentiated the contractile responses to norepinephrine and the periarterial nerve stimulation.	Norepinephrine	86-100	endothelin 1	Rattus norvegicus	32-44
7738470-4	1995	Since it has recently been shown that the selective block of alpha 2-adrenoreceptors located on noradrenergic axon terminals resulted in an increase in the release of noradrenaline (NA), both in the central and peripheral nervous systems, and, in our experiments, that propranolol prevented the effect of alpha 2-adrenoreceptor blockade on TNF-alpha plasma levels induced by LPS, it seems likely that the excessive stimulation by NA of beta-adrenoreceptors located on cytokine-secreting immune cells is responsible for this action.	Norepinephrine	167-180	tumor necrosis factor	Mus musculus	340-349
7753398-5	1995	The beta-1 adrenoceptor antagonist atenolol (10(-5) M) blocked the norepinephrine-induced increase in excitability but the alpha antagonist phentolamine (10(-5) M) did not.	Norepinephrine	67-81	adrenoceptor beta 1	Rattus norvegicus	4-23
7696075-4	1995	Plasma noradrenaline and cortisol concentrations increased significantly during major surgery and there were significant correlations between the increase in these counter-regulatory hormones and the amount of insulin administered.	Norepinephrine	7-20	insulin	Homo sapiens	210-217
7648606-7	1995	There is evidence indicating that LHRH neurons themselves have endogenous pulse-generating mechanisms but that the pulsatility of LHRH release is also modulated by input from neuropeptide Y (NPY) and norepinephrine (NE) neurons.	Norepinephrine	200-214	gonadotropin releasing hormone 1	Macaca mulatta	130-134
7830053-6	1995	As with forskolin and cholera toxin, physiological signaling molecules such as vasoactive intestinal polypeptide (VIP) and AMP, for which PC12 cells are known to have receptors linked to activation of adenylate cyclase, also inhibited norepinephrine uptake.	Norepinephrine	235-249	vasoactive intestinal peptide	Rattus norvegicus	79-112
7830053-6	1995	As with forskolin and cholera toxin, physiological signaling molecules such as vasoactive intestinal polypeptide (VIP) and AMP, for which PC12 cells are known to have receptors linked to activation of adenylate cyclase, also inhibited norepinephrine uptake.	Norepinephrine	235-249	vasoactive intestinal peptide	Rattus norvegicus	114-117
7536159-5	1995	The facilitation by endothelin-1 of responses to trains of stimulation (10 Hz for 10 s) was absent in the presence of the P2-purinoceptor antagonist, suramin, in concentrations which antagonised the contractile effects of alpha, beta-methylene ATP, but not those of noradrenaline.	Norepinephrine	266-279	endothelin 1	Rattus norvegicus	20-32
8713957-4	1995	Oxytocin release following CCK (and that during parturition) is potently inhibited by morphine, which blocks the local noradrenaline release in the supraoptic nucleus.	Norepinephrine	119-132	cholecystokinin	Homo sapiens	27-30
7712013-13	1995	Contractions of the vas deferens evoked by either ATP (10 micro M-3 mM) or noradrenaline (1-1000 micro M) in the capsaicin-treated group showed no significant difference between control and capsaicin treated rats.6.	Norepinephrine	75-88	arginine vasopressin	Rattus norvegicus	20-23
7815811-6	1995	Endothelin-1 concentrations that did not increase coronary perfusion pressure (5 to 10 pmol) caused significant coronary constriction in the presence of norepinephrine (10 nmol/L).	Norepinephrine	153-167	endothelin 1	Homo sapiens	0-12
7798510-9	1995	Norepinephrine spillover declined during vehicle infusions (612 +/- 367 to 418 +/- 196 ng/min, p < 0.05) but not during angiotensin II infusions despite a greater increase in mean arterial pressure when the subpressor angiotensin II was combined with head-down tilt and phenylephrine (6.0 +/- 7.0 mm Hg during vehicle; 14 +/- 9.4 mm Hg during angiotensin II, p < 0.01).	Norepinephrine	0-14	angiotensinogen	Homo sapiens	221-235
7798510-9	1995	Norepinephrine spillover declined during vehicle infusions (612 +/- 367 to 418 +/- 196 ng/min, p < 0.05) but not during angiotensin II infusions despite a greater increase in mean arterial pressure when the subpressor angiotensin II was combined with head-down tilt and phenylephrine (6.0 +/- 7.0 mm Hg during vehicle; 14 +/- 9.4 mm Hg during angiotensin II, p < 0.01).	Norepinephrine	0-14	angiotensinogen	Homo sapiens	221-235
7529313-1	1995	The role of inducible nitric oxide synthase (iNOS) was examined in the hypotension and vascular hyporesponsiveness to norepinephrine (NE) invoked by lipopolysaccharide (LPS) in pentobarbital-anesthetized rats.	Norepinephrine	118-132	nitric oxide synthase 2	Rattus norvegicus	12-43
7529313-1	1995	The role of inducible nitric oxide synthase (iNOS) was examined in the hypotension and vascular hyporesponsiveness to norepinephrine (NE) invoked by lipopolysaccharide (LPS) in pentobarbital-anesthetized rats.	Norepinephrine	118-132	nitric oxide synthase 2	Rattus norvegicus	45-49
7596229-3	1995	We therefore studied the effect of NPY infusion on the suppressed pressor effect of norepinephrine (NE), angiotensin II (AII), vasopressin (VP), and endothelin (ET) in conscious endotoxemic rats.	Norepinephrine	84-98	neuropeptide Y	Rattus norvegicus	35-38
7815811-10	1995	Coronary vasoconstriction caused by endothelin-1 is enhanced by ischemia-reperfusion and by norepinephrine present in concentrations typically observed after neonatal cardiopulmonary bypass.	Norepinephrine	92-106	endothelin 1	Homo sapiens	36-48
7614255-6	1995	There was a statistically significant negative correlation between the response of NK cells to the stimulators IL-2 and IFN-alpha and the level of plasma norepinephrine in the heart failure patients.	Norepinephrine	154-168	interleukin 2	Homo sapiens	111-115
7614255-6	1995	There was a statistically significant negative correlation between the response of NK cells to the stimulators IL-2 and IFN-alpha and the level of plasma norepinephrine in the heart failure patients.	Norepinephrine	154-168	interferon alpha 1	Homo sapiens	120-129
7614255-7	1995	This was corroborated by in vitro testing of direct effects of norepinephrine on normal NK cells, which indicated that baseline cytotoxicity and the ability of these cells to respond to IL-2 were inhibited in a dose-dependent manner.	Norepinephrine	63-77	interleukin 2	Homo sapiens	186-190
7731501-1	1995	It is well known that the adrenal medulla contains high concentrations of neuropeptide Y (NPY) where it coexists with epinephrine and norepinephrine.	Norepinephrine	134-148	neuropeptide Y	Rattus norvegicus	74-88
7740661-1	1995	Norepinephrine release from adrenergic nerve terminals leads to a rise in intracellular Ca2+, which promotes penile smooth muscle contraction and detumescence.	Norepinephrine	0-14	carbonic anhydrase 2	Oryctolagus cuniculus	88-91
7731501-1	1995	It is well known that the adrenal medulla contains high concentrations of neuropeptide Y (NPY) where it coexists with epinephrine and norepinephrine.	Norepinephrine	134-148	neuropeptide Y	Rattus norvegicus	90-93
7700724-8	1995	A significant relationship (p < 0.04) was found between CGA and norepinephrine levels.	Norepinephrine	67-81	chromogranin A	Homo sapiens	59-62
7698201-3	1994	Doses of noradrenaline from 40 to 160 ng.kg-1 had similar pressor effects in the treated and control rats, while the pressor response to the highest dose of noradrenaline (320 ng.kg-1) was significantly lower (P < 0.01) in the vasopressin V2 receptor agonist-treated rats.	Norepinephrine	157-170	arginine vasopressin receptor 2	Rattus norvegicus	230-253
7895065-5	1994	While no change in sensitivity to TNF was observed in the hippocampus after one day of desipramine administration, TNF enhanced, rather than inhibited [3H]norepinephrine release after 14 days.	Norepinephrine	155-169	tumor necrosis factor	Rattus norvegicus	115-118
7702805-0	1994	Effect of insulin on the venoconstrictive response to norepinephrine in normal human subjects: the influence of sodium status.	Norepinephrine	54-68	insulin	Homo sapiens	10-17
7702805-11	1994	Only an insulin dose of 0.8 mU/min on a low sodium diet was able to significantly dilate the norepinephrine preconstricted vein (77 +/- 9% of baseline diameter versus ED50) (P = .002).	Norepinephrine	93-107	insulin	Homo sapiens	8-15
7882823-2	1994	OBJECTIVE: To evaluate the effect of angiotensin-converting enzyme (ACE) inhibition on the pressor responsiveness to norepinephrine in type II diabetes.	Norepinephrine	117-131	angiotensin I converting enzyme	Homo sapiens	37-66
7882823-2	1994	OBJECTIVE: To evaluate the effect of angiotensin-converting enzyme (ACE) inhibition on the pressor responsiveness to norepinephrine in type II diabetes.	Norepinephrine	117-131	angiotensin I converting enzyme	Homo sapiens	68-71
7876273-13	1994	Basal noradrenaline concentration decreased by 30% after phenylephrine, whereas angiotensin II increased noradrenaline levels to 226% of control.	Norepinephrine	105-118	angiotensinogen	Rattus norvegicus	80-94
7888288-4	1994	Threshold concentrations of ET-1 have been found to amplify specifically contractions induced by noradrenaline and serotonin.	Norepinephrine	97-110	endothelin 1	Homo sapiens	28-32
7989494-0	1994	Angiotensin-II mediates norepinephrine and neuropeptide-Y secretion in a human pheochromocytoma.	Norepinephrine	24-38	angiotensinogen	Homo sapiens	0-14
7964729-2	1994	Addition of optimal concentrations of either endothelin-1 (ET-1), ATP, oxotremorine-M (Oxo-M), or norepinephrine (NE) all resulted in an increase in the concentration of cytosolic calcium (Ca2+i) but of different magnitudes (ET-1 = ATP > Oxo-M > NE).	Norepinephrine	98-112	endothelin 1	Homo sapiens	225-229
7727801-4	1994	In the corticosterone response to CRH administered icv, a moderate involvement of hypothalamic alpha 1-adrenergic receptors and neuronal noradrenaline seems possible.	Norepinephrine	137-150	corticotropin releasing hormone	Rattus norvegicus	34-37
7809204-4	1994	In vas deferens, P. tricornutum and C. stigmatophora inhibited the contractions induced by noradrenaline, whilst S. costatum showed a non-dose-dependent potentiation.	Norepinephrine	91-104	arginine vasopressin	Rattus norvegicus	3-6
7867554-2	1995	The sympathetic nervous system, via norepinephrine and cAMP, and thyroid hormone seem to be the major regulators of UCP expression.	Norepinephrine	36-50	uncoupling protein 1	Rattus norvegicus	116-119
7729809-5	1994	A parallel role of norepinephrine (NE) neurons in the modulation of pulsatile LHRH release was also observed indicating that more than one neuronal system can be simultaneously involved in the regulation of LHRH release and the action of ovarian steroids.	Norepinephrine	19-33	gonadotropin releasing hormone 1	Macaca mulatta	78-82
7729809-5	1994	A parallel role of norepinephrine (NE) neurons in the modulation of pulsatile LHRH release was also observed indicating that more than one neuronal system can be simultaneously involved in the regulation of LHRH release and the action of ovarian steroids.	Norepinephrine	19-33	gonadotropin releasing hormone 1	Macaca mulatta	207-211
7898071-1	1994	We wished to determine if chronic neuropeptide Y (NPY) infusion (1 ng/min for 1 week by Alzet minipump) could decrease plasma renin activity (PRA) and norepinephrine (NE) in a rat myocardial infarction (MI) model of moderate compensated congestive heart failure (CHF).	Norepinephrine	151-165	neuropeptide Y	Rattus norvegicus	34-48
7898071-1	1994	We wished to determine if chronic neuropeptide Y (NPY) infusion (1 ng/min for 1 week by Alzet minipump) could decrease plasma renin activity (PRA) and norepinephrine (NE) in a rat myocardial infarction (MI) model of moderate compensated congestive heart failure (CHF).	Norepinephrine	151-165	neuropeptide Y	Rattus norvegicus	50-53
7989494-4	1994	Angiotensin-II increased the release of norepinephrine and neuropeptide-Y by the pheochromocytes.	Norepinephrine	40-54	angiotensinogen	Homo sapiens	0-14
7876273-14	1994	Evoked noradrenaline overflow was not changed after phenylephrine but was increased to 204% of control after angiotensin II.	Norepinephrine	7-20	angiotensinogen	Rattus norvegicus	109-123
7961964-1	1994	Dopamine beta-hydroxylase (DBH; EC 1.14.17.1) catalyzes the production of the neurotransmitter and hormone norepinephrine in the third step of the catecholamine biosynthesis pathway.	Norepinephrine	107-121	dopamine beta hydroxylase	Mus musculus	0-25
7961964-1	1994	Dopamine beta-hydroxylase (DBH; EC 1.14.17.1) catalyzes the production of the neurotransmitter and hormone norepinephrine in the third step of the catecholamine biosynthesis pathway.	Norepinephrine	107-121	dopamine beta hydroxylase	Mus musculus	27-30
7531114-7	1994	RESULTS: In the healthy controls noradrenaline (60, 120, and 240 pmol.min-1) and L-NMMA (1, 2, and 4 mumol.min-1) produced similar reductions in resting forearm blood flow.	Norepinephrine	33-46	CD59 molecule (CD59 blood group)	Homo sapiens	70-75
7849180-2	1994	Cl- currents could be activated with varying frequency by noradrenaline (primarily alpha- and beta 1-adrenoceptor-selective agonist, 1-5 microM), isoprenaline (nonselective beta-adrenoceptor agonist, 5 microM), salbutamol (beta 2-adrenoceptor-selective agonist, 2 microM), and phenylephrine (alpha 1-adrenoceptor-selective agonist, 1-2 microM).	Norepinephrine	58-71	adrenoceptor beta 1	Rattus norvegicus	83-113
7849180-4	1994	In the presence of phentolamine (nonselective alpha-adrenoceptor antagonist, 15 microM), noradrenaline elicited Cl- current activation in 63% of the cells examined, whereas noradrenaline-induced activation was observed in 33% of the cells examined in the presence of both atenolol and butoxamine (beta 1- and beta 2-adrenoceptor antagonists, respectively, 10 microM).	Norepinephrine	89-102	adrenoceptor beta 1	Rattus norvegicus	297-328
7849180-4	1994	In the presence of phentolamine (nonselective alpha-adrenoceptor antagonist, 15 microM), noradrenaline elicited Cl- current activation in 63% of the cells examined, whereas noradrenaline-induced activation was observed in 33% of the cells examined in the presence of both atenolol and butoxamine (beta 1- and beta 2-adrenoceptor antagonists, respectively, 10 microM).	Norepinephrine	173-186	adrenoceptor beta 1	Rattus norvegicus	297-328
7858880-0	1994	Presence of neuropeptide Y in the rat seminal vesicle and its effects on noradrenaline- and nerve-induced contractions.	Norepinephrine	73-86	neuropeptide Y	Rattus norvegicus	12-26
7530120-4	1994	The contractile response induced by noradrenaline was competitively antagonized by representative alpha 1-adrenoceptor antagonists (prazosin, WB4101, 5-methylurapidil and HV723), the dissociation constants (pKB) being < 8.5.	Norepinephrine	36-49	AKT serine/threonine kinase 1	Homo sapiens	207-210
7532079-15	1994	Concentration-response relationships for ATP and noradrenaline were studied in the presence of reactive blue 2 (20 microM); the P2y-antagonist significantly inhibited the relaxant response to ATP, but not that to noradrenaline.	Norepinephrine	49-62	purinergic receptor P2Y1	Rattus norvegicus	128-131
7896069-0	1994	Altered alpha-adrenergic responses of vas deferens to noradrenaline and tyramine from rats with short- and long-term alloxan diabetes.	Norepinephrine	54-67	arginine vasopressin	Rattus norvegicus	38-41
7956940-0	1994	Microinjection of norepinephrine into the paraventricular nucleus of the hypothalamus stimulates corticotropin-releasing factor gene expression in conscious rats.	Norepinephrine	18-32	corticotropin releasing hormone	Rattus norvegicus	97-127
7896056-0	1994	Effects of vasoactive intestinal peptide and its homologues on the noradrenaline-mediated secretion of fluid and protein from the rat submandibular gland.	Norepinephrine	67-80	vasoactive intestinal peptide	Rattus norvegicus	11-40
7896056-2	1994	Noradrenaline-mediated secretion of fluid and protein from rat submandibular glands was enhanced by vasoactive intestinal peptide (VIP) and secretin but not by peptide histidine isoleucine (PHI) or gastric inhibitory peptide (GIP).	Norepinephrine	0-13	vasoactive intestinal peptide	Rattus norvegicus	100-129
7894215-8	1994	In analogy to the results of experimental studies showing that angiotensin II and noradrenaline act as growth factors on cardiac and vascular cells, cardiovascular remodeling present in our patient with Bartter"s syndrome may be explained by increased activity of angiotensin II and/or noradrenaline.	Norepinephrine	82-95	angiotensinogen	Homo sapiens	264-278
7894215-8	1994	In analogy to the results of experimental studies showing that angiotensin II and noradrenaline act as growth factors on cardiac and vascular cells, cardiovascular remodeling present in our patient with Bartter"s syndrome may be explained by increased activity of angiotensin II and/or noradrenaline.	Norepinephrine	286-299	angiotensinogen	Homo sapiens	63-77
7896069-4	1994	In the present study, contractile effects of noradrenaline and tyramine in isolated vas deferens from rats with short- and long-term alloxan diabetes were investigated by comparing with those from control rats.	Norepinephrine	45-58	arginine vasopressin	Rattus norvegicus	84-87
7896056-2	1994	Noradrenaline-mediated secretion of fluid and protein from rat submandibular glands was enhanced by vasoactive intestinal peptide (VIP) and secretin but not by peptide histidine isoleucine (PHI) or gastric inhibitory peptide (GIP).	Norepinephrine	0-13	vasoactive intestinal peptide	Rattus norvegicus	131-134
7896069-5	1994	For this purpose, intrinsic activities (alpha E value) and apparent affinity constants (pD2 value) for contractile effects of noradrenaline and tyramine in the isolated rat vas deferens were calculated in normal rats and rats with short- and long-term alloxan diabetes.	Norepinephrine	126-139	arginine vasopressin	Rattus norvegicus	173-176
7896056-2	1994	Noradrenaline-mediated secretion of fluid and protein from rat submandibular glands was enhanced by vasoactive intestinal peptide (VIP) and secretin but not by peptide histidine isoleucine (PHI) or gastric inhibitory peptide (GIP).	Norepinephrine	0-13	gastric inhibitory polypeptide	Rattus norvegicus	226-229
7896069-7	1994	Apparent affinity constants for contractile effects of noradrenaline in the isolated rat vas deferens were increased depending on both short- and long-term alloxan diabetes.	Norepinephrine	55-68	arginine vasopressin	Rattus norvegicus	89-92
7896069-9	1994	Intrinsic activities for both noradrenaline- and tyramine-induced contractions of rat vas deferens, however, were increased due to short-term diabetes and decreased due to long-term diabetes.	Norepinephrine	30-43	arginine vasopressin	Rattus norvegicus	86-89
7875540-4	1994	In transgenic, but not in control aorta, pretreatment with angiotensinogen potentiated norepinephrine-induced vasoconstrictions, this effect being abolished by captopril.	Norepinephrine	87-101	angiotensinogen	Rattus norvegicus	59-74
7931338-0	1994	Neuroprotective effects of some monoamine oxidase-B inhibitors against DSP-4-induced noradrenaline depletion in the mouse hippocampus.	Norepinephrine	85-98	monoamine oxidase B	Mus musculus	32-51
8000434-1	1994	We cloned and sequenced the mouse phenylethanolamine N-methyltransferase (PNMT) gene which encodes the enzyme that catalyses the conversion of norepinephrine to epinephrine.	Norepinephrine	143-157	phenylethanolamine-N-methyltransferase	Mus musculus	34-72
8000434-1	1994	We cloned and sequenced the mouse phenylethanolamine N-methyltransferase (PNMT) gene which encodes the enzyme that catalyses the conversion of norepinephrine to epinephrine.	Norepinephrine	143-157	phenylethanolamine-N-methyltransferase	Mus musculus	74-78
7926489-2	1994	IL-1 beta suppresses norepinephrine release from the myenteric plexus, but the effect of IL-6 is unknown.	Norepinephrine	21-35	interleukin 1 beta	Homo sapiens	0-9
7926489-3	1994	Therefore, we investigated the effects of IL-6 alone and in combination with IL-1 beta on norepinephrine release.	Norepinephrine	90-104	interleukin 6	Homo sapiens	42-46
7926489-3	1994	Therefore, we investigated the effects of IL-6 alone and in combination with IL-1 beta on norepinephrine release.	Norepinephrine	90-104	interleukin 1 beta	Homo sapiens	77-86
7926489-7	1994	CONCLUSIONS: Because 3H release reflects [3H]norepinephrine release, our results show that IL-6 exerts a dual effect on norepinephrine release.	Norepinephrine	45-59	interleukin 6	Homo sapiens	91-95
7926489-8	1994	Furthermore, there is synergism between IL-1 beta and IL-6 resulting in suppression of norepinephrine release.	Norepinephrine	87-101	interleukin 1 beta	Homo sapiens	40-49
7926489-8	1994	Furthermore, there is synergism between IL-1 beta and IL-6 resulting in suppression of norepinephrine release.	Norepinephrine	87-101	interleukin 6	Homo sapiens	54-58
7828007-4	1994	During and after feeding, NPY enhanced the feeding-induced insulin response (P < 0.01) and attenuated the feeding-induced norepinephrine response (P < 0.05).	Norepinephrine	125-139	neuropeptide Y	Rattus norvegicus	26-29
7929822-5	1994	Abdominal aortic constriction (7 d) and subcutaneous norepinephrine infusion (36 h) each caused ventricular hypertrophy associated with 3.1-fold and 3.8-fold increases, respectively, in TGF-beta 1 mRNA in the myocyte fraction, but had no effect on the level of TGF-beta 1 mRNA in the nonmyocyte fraction.	Norepinephrine	53-67	transforming growth factor, beta 1	Rattus norvegicus	186-196
7833219-5	1994	In this study the effects of a specific inhibitor of nitric oxide synthase, L-NG-monomethyl-arginine (L-NMMA) and noradrenaline on the vasodilator responses to bradykinin were examined in the forearm arterial bed of healthy volunteers.	Norepinephrine	114-127	kininogen 1	Homo sapiens	160-170
7833219-12	1994	The response to bradykinin, but not that to GTN, was attenuated by L-NMMA compared with noradrenaline (P < 0.05; n = 6), suggesting that bradykinin-induced vasodilatation in the forearm is mediated, at least in part, by stimulating release of nitric oxide.	Norepinephrine	88-101	kininogen 1	Homo sapiens	140-150
7929822-5	1994	Abdominal aortic constriction (7 d) and subcutaneous norepinephrine infusion (36 h) each caused ventricular hypertrophy associated with 3.1-fold and 3.8-fold increases, respectively, in TGF-beta 1 mRNA in the myocyte fraction, but had no effect on the level of TGF-beta 1 mRNA in the nonmyocyte fraction.	Norepinephrine	53-67	transforming growth factor, beta 1	Rattus norvegicus	261-271
7929822-6	1994	In ventricular myocytes, norepinephrine likewise caused a 4.1-fold increase in TGF-beta 1 mRNA associated with an increase in TGF-beta bioactivity.	Norepinephrine	25-39	transforming growth factor, beta 1	Rattus norvegicus	79-89
7929822-6	1994	In ventricular myocytes, norepinephrine likewise caused a 4.1-fold increase in TGF-beta 1 mRNA associated with an increase in TGF-beta bioactivity.	Norepinephrine	25-39	transforming growth factor, beta 1	Rattus norvegicus	79-87
7929822-7	1994	This induction of TGF-beta 1 mRNA occurred at norepinephrine concentrations as low as 1 nM and was blocked by prazosin, but not propranolol.	Norepinephrine	46-60	transforming growth factor, beta 1	Rattus norvegicus	18-28
7929822-9	1994	Thus, the cardiac myocyte responds to two hypertrophic stimuli, pressure overload and norepinephrine, with the induction of TGF-beta 1.	Norepinephrine	86-100	transforming growth factor, beta 1	Rattus norvegicus	124-134
7523633-9	1994	Norepinephrine also induces AVP release from both the hypothalamus, as well as the amygdala.	Norepinephrine	0-14	arginine vasopressin	Homo sapiens	28-31
7523633-10	1994	The norepinephrine-induced AVP release is antagonized by phentolamine, but not by propranolol, suggesting an alpha-adrenergic receptor-mediated AVP response in both brain regions.	Norepinephrine	4-18	arginine vasopressin	Homo sapiens	27-30
7523633-10	1994	The norepinephrine-induced AVP release is antagonized by phentolamine, but not by propranolol, suggesting an alpha-adrenergic receptor-mediated AVP response in both brain regions.	Norepinephrine	4-18	arginine vasopressin	Homo sapiens	144-147
7838010-3	1994	These receptors are particularly dense on catecholaminergic synaptic terminals, and, while effects are variable dependent on brain region, several studies indicate that insulin promotes central catecholaminergic activity, perhaps by inhibiting synaptic re-uptake of norepinephrine.	Norepinephrine	266-280	insulin	Homo sapiens	169-176
7700690-2	1994	The caffeine-induced elevated intracellular cAMP resulted in normalization of myocardial contractility in reperfusion, as well as in stabilization of norepinephrine levels and cardiac adrenoreactivity during ischemia and reperfusion.	Norepinephrine	150-164	cathelicidin antimicrobial peptide	Rattus norvegicus	44-48
7813553-0	1994	Heterogeneity of prejunctional neuropeptide Y receptors inhibiting noradrenaline overflow in the portal vein of freely moving rats.	Norepinephrine	67-80	neuropeptide Y	Rattus norvegicus	31-45
7842383-7	1994	Similarly, in the presence of 10(-6) M norepinephrine, ANG II caused significant, concentration-dependent constriction of renal artery.	Norepinephrine	39-53	angiotensinogen	Rattus norvegicus	55-61
7813592-2	1994	In binding experiments using l-noradrenaline to compete for [3H]p-aminoclonidine binding sites, angiotensin II (1 nM) increased the IC50 value of l-noradrenaline by 50%.	Norepinephrine	29-44	angiotensinogen	Rattus norvegicus	96-110
7813592-2	1994	In binding experiments using l-noradrenaline to compete for [3H]p-aminoclonidine binding sites, angiotensin II (1 nM) increased the IC50 value of l-noradrenaline by 50%.	Norepinephrine	146-161	angiotensinogen	Rattus norvegicus	96-110
7813592-4	1994	The modulatory effect of angiotensin II was also evaluated after addition of both DUP753 and PD123319, an angiotensin AT2 receptor antagonist, and counteraction of the reduction in the IC50 value of l-noradrenaline was observed.	Norepinephrine	199-214	angiotensinogen	Rattus norvegicus	25-39
7813592-6	1994	Cardiovascular analysis demonstrated that a threshold dose of angiotensin II (0.05 pmol) counteracted the vasodepressor effect produced by an ED50 dose of l-adrenaline, l-noradrenaline or clonidine coinjected in the nucleus tractus solitarii.	Norepinephrine	169-184	angiotensinogen	Rattus norvegicus	62-76
7813553-2	1994	Neuropeptide Y dose dependently (2-2000 ng/kg/min) attenuated the electrically evoked noradrenaline overflow and almost complete blockade was reached at the highest dose used.	Norepinephrine	86-99	neuropeptide Y	Rattus norvegicus	0-14
7813553-5	1994	Only at the highest dose did neuropeptide Y (2000 ng/kg/min) and [Leu31,Pro34]neuropeptide Y (20,000 ng/kg/min) significantly enhance mean arterial pressure and decrease heart rate and basal plasma noradrenaline levels, the latter two effects being due to the baroreceptor reflex.	Norepinephrine	198-211	neuropeptide Y	Rattus norvegicus	29-43
7813553-5	1994	Only at the highest dose did neuropeptide Y (2000 ng/kg/min) and [Leu31,Pro34]neuropeptide Y (20,000 ng/kg/min) significantly enhance mean arterial pressure and decrease heart rate and basal plasma noradrenaline levels, the latter two effects being due to the baroreceptor reflex.	Norepinephrine	198-211	neuropeptide Y	Rattus norvegicus	78-92
7813553-7	1994	The results indicate the presence of prejunctional neuropeptide Y Y1 receptors, and possibly the coexistence of Y1 and Y2 receptors, in the portal vein of freely moving rats, which in conjunction are able to inhibit markedly electrically evoked noradrenaline overflow.	Norepinephrine	245-258	neuropeptide Y	Rattus norvegicus	51-65
8001651-5	1994	Endothelin-1 caused a decrease in the positive chronotropic and inotropic responses to sympathetic nerve stimulation and to noradrenaline; these inhibitory effects of endothelin-1 were not altered in 2-, 4-, 8- or 12-week diabetic rats.	Norepinephrine	124-137	endothelin 1	Rattus norvegicus	0-12
7988782-2	1994	Insulin per se (SA-EU vs HI-INS-EU), suppressed plasma glucagon (approximately 20%) and pancreatic polypeptide (approximately 30%), whereas it increased plasma noradrenaline (approximately 10%, p < 0.05).	Norepinephrine	160-173	insulin	Homo sapiens	0-7
8074198-9	1994	Moreover, the normal effect of insulin to shift the norepinephrine pressor dose-response curve to the right is impaired in these patients.	Norepinephrine	52-66	insulin	Homo sapiens	31-38
7955585-2	1994	infusion of the selective vasopressin (V2) agonist 1-desamino-8-D-arginine vasopressin (DDAVP, Desmopressin) in humans causes a fall in blood pressure, an increase in heart rate, and a rise in plasma renin and noradrenaline.	Norepinephrine	210-223	arginine vasopressin	Homo sapiens	26-37
7955585-2	1994	infusion of the selective vasopressin (V2) agonist 1-desamino-8-D-arginine vasopressin (DDAVP, Desmopressin) in humans causes a fall in blood pressure, an increase in heart rate, and a rise in plasma renin and noradrenaline.	Norepinephrine	210-223	arginine vasopressin	Homo sapiens	75-86
8026008-7	1994	Short-term smoking (n = 11) increased blood pressure, heart rate, and plasma epinephrine concentrations (P < .05 or less); enhanced endothelin-1-induced vasoconstriction (delta FVR, 457 +/- 192% versus 254 +/- 143%, P < .01); and decreased norepinephrine-induced vasoconstriction (P < .05), but had no effect on the other interventions.	Norepinephrine	246-260	endothelin 1	Homo sapiens	135-147
8071854-4	1994	Vasopressin produced further contractions in arterial rings with or without endothelium precontracted with prostaglandin F2 alpha or norepinephrine.	Norepinephrine	133-147	arginine vasopressin	Homo sapiens	0-11
7990977-4	1994	Coinfusion of noradrenaline with a weakly venodilating, constant dose of VIP (93.2 pmol/min) caused a 0.5-fold decrease in the sensitivity for noradrenaline.	Norepinephrine	14-27	vasoactive intestinal peptide	Homo sapiens	73-76
7990977-4	1994	Coinfusion of noradrenaline with a weakly venodilating, constant dose of VIP (93.2 pmol/min) caused a 0.5-fold decrease in the sensitivity for noradrenaline.	Norepinephrine	143-156	vasoactive intestinal peptide	Homo sapiens	73-76
8030694-8	1994	The postnatal norepinephrine and epinephrine surge was blunted in response to corticosteroid and corticosteroid plus thyrotropin-releasing hormone treatment.	Norepinephrine	14-28	LOW QUALITY PROTEIN: thyrotropin-releasing hormone	Ovis aries	117-146
7880876-1	1994	Neuropeptide Y (NPY) is co-released with norepinephrine (NE) from sympathetic neurons, which innervate blood vessels, and acts to potentiate NE-induced smooth muscle contraction.	Norepinephrine	41-55	neuropeptide Y	Rattus norvegicus	0-14
7880876-1	1994	Neuropeptide Y (NPY) is co-released with norepinephrine (NE) from sympathetic neurons, which innervate blood vessels, and acts to potentiate NE-induced smooth muscle contraction.	Norepinephrine	41-55	neuropeptide Y	Rattus norvegicus	16-19
7976403-0	1994	Inhibition of neuropeptide Y-induced augmentation of noradrenaline-induced vasoconstriction by D-myo-inositol 1,2,6-trisphosphate in the rat mesenteric arterial bed.	Norepinephrine	53-66	neuropeptide Y	Rattus norvegicus	14-28
8023917-1	1994	The effect of an infusion of norepinephrine (0.42 nmol.kg-1.min-1) on energy metabolism in the whole body (using indirect calorimetry and the arteriovenous forearm catheterization techniques in eight healthy young male adults.	Norepinephrine	29-43	CD59 molecule (CD59 blood group)	Homo sapiens	60-65
7976403-2	1994	Neuropeptide Y (1 and 10 nM) had no direct postjunctional effects, but augmented vasoconstrictor responses to noradrenaline and to sympathetic nerve stimulation to an extent which was greater with the higher concentration of neuropeptide Y.	Norepinephrine	110-123	neuropeptide Y	Rattus norvegicus	0-14
7976403-3	1994	The augmenting effect of neuropeptide Y at 1 nM on vasoconstriction induced by lower doses of noradrenaline was antagonized by alpha-trinositol (1 microM), producing a shift to the right of the dose-response curve.	Norepinephrine	94-107	neuropeptide Y	Rattus norvegicus	25-39
7976403-5	1994	Augmentation by the higher concentration of neuropeptide Y (10 nM) of noradrenaline-induced vasoconstriction was not affected by alpha-trinositol at concentrations of up to 10 microM.	Norepinephrine	70-83	neuropeptide Y	Rattus norvegicus	44-58
7976403-10	1994	These results suggest that alpha-trinositol can be a useful functional antagonist of neuropeptide Y-induced augmentation of vasoconstrictor responses to noradrenaline in the rat mesenteric arterial bed.	Norepinephrine	153-166	neuropeptide Y	Rattus norvegicus	85-99
7957611-3	1994	CGRP (10(-9) to 10(-7) M) and angiotensin II (10(-9) to 10(-5) M) caused concentration-dependent increases in force of contraction in atrial trabeculae (up to 36 +/- 8% and 42 +/- 8% of the response to 10(-5) M noradrenaline, respectively).	Norepinephrine	211-224	calcitonin related polypeptide alpha	Homo sapiens	0-4
7957611-3	1994	CGRP (10(-9) to 10(-7) M) and angiotensin II (10(-9) to 10(-5) M) caused concentration-dependent increases in force of contraction in atrial trabeculae (up to 36 +/- 8% and 42 +/- 8% of the response to 10(-5) M noradrenaline, respectively).	Norepinephrine	211-224	angiotensinogen	Homo sapiens	30-44
7801766-1	1994	Endothelin-1 (ET-1) caused slow-developing and stable vasoconstrictions in isolated rings of rat thoracic aortae with a pD2 value of 7.55 +/- 0.10 compared to pD2 values of 9.30 +/- 0.10 and 8.36 +/- 0.30 for angiotensin II and norepinephrine, respectively.	Norepinephrine	228-242	endothelin 1	Rattus norvegicus	0-12
7801766-1	1994	Endothelin-1 (ET-1) caused slow-developing and stable vasoconstrictions in isolated rings of rat thoracic aortae with a pD2 value of 7.55 +/- 0.10 compared to pD2 values of 9.30 +/- 0.10 and 8.36 +/- 0.30 for angiotensin II and norepinephrine, respectively.	Norepinephrine	228-242	endothelin 1	Rattus norvegicus	14-18
8013086-2	1994	Pretreatment with TGF-beta 1 potentiated norepinephrine (NE)-induced and stretch-induced (+10% and +20% elongation, for 30 minutes) c-fos mRNA expression by 2.2-fold, whereas TGF-beta 1 alone did not induce c-fos mRNA expression in Northern blot analysis.	Norepinephrine	41-55	transforming growth factor, beta 1	Rattus norvegicus	18-28
7965011-12	1994	GCl(V) was increased by 10 microM norepinephrine, and by activation of protein kinase A (PKA) with 1 mM 8-bromoadenosine cyclic monophosphate (8-Br cAMP).	Norepinephrine	34-48	germ cell-less 1, spermatogenesis associated	Rattus norvegicus	0-3
8024910-6	1994	The concentration of noradrenaline in plasma and urine indicated that ACE inhibition caused attenuated release of noradrenaline.	Norepinephrine	21-34	angiotensin I converting enzyme	Homo sapiens	70-73
8024910-6	1994	The concentration of noradrenaline in plasma and urine indicated that ACE inhibition caused attenuated release of noradrenaline.	Norepinephrine	114-127	angiotensin I converting enzyme	Homo sapiens	70-73
8024910-7	1994	The results support the concept that angiotensin II facilitates release of noradrenaline from sympathetic nerves and that ACE inhibition inhibits this release.	Norepinephrine	75-88	angiotensinogen	Homo sapiens	37-51
7954098-1	1994	In heart failure, both the sympathetic nervous system and the renin angiotensin system play important pathophysiological roles, and the two systems may interact with each other, e.g., angiotensin II facilitating noradrenaline release.	Norepinephrine	212-225	renin	Homo sapiens	62-67
7954098-1	1994	In heart failure, both the sympathetic nervous system and the renin angiotensin system play important pathophysiological roles, and the two systems may interact with each other, e.g., angiotensin II facilitating noradrenaline release.	Norepinephrine	212-225	angiotensinogen	Homo sapiens	184-198
8187273-1	1994	It is well-documented that norepinephrine (NE) induces the expression of immediate-early genes (IEGs), such as c-fos, c-jun, and jun-B, in cultured neonatal heart cells and leads to cell growth without cell division (ie, hypertrophy).	Norepinephrine	27-41	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	129-134
8023943-0	1994	Mechanism underlying tumor necrosis factor-alpha suppression of norepinephrine release from rat myenteric plexus.	Norepinephrine	64-78	tumor necrosis factor	Rattus norvegicus	21-48
8023984-6	1994	Pretreatment of rings with superoxide dismutase or catalase did not change X+XO-induced inhibition of platelet-mediated relaxation, but it abolished the X+XO-induced contraction of rings as well as subsequent potentiation of norepinephrine-mediated contraction.	Norepinephrine	225-239	catalase	Rattus norvegicus	51-59
8206583-0	1994	Vasoconstriction with norepinephrine causes less forearm insulin resistance than a reflex sympathetic vasoconstriction.	Norepinephrine	22-36	insulin	Homo sapiens	57-64
8070689-12	1994	Catalase (1000 U/ml) also partially attenuated the loss of vascular norepinephrine responsiveness.	Norepinephrine	68-82	catalase	Rattus norvegicus	0-8
8189249-1	1994	Neuropeptide Y is colocalized with noradrenaline in sympathetic fibers innervating the rat pineal gland.	Norepinephrine	35-48	neuropeptide Y	Rattus norvegicus	0-14
8206583-8	1994	The same degree of reduction in forearm blood flow with a predominantly alpha-adrenergic agonist, norepinephrine (group 2), causes much less insulin resistance (a decrease in utilization of 13%) (P < .04).	Norepinephrine	98-112	insulin	Homo sapiens	141-148
8200981-0	1994	Interactions between insulin and norepinephrine on blood pressure and insulin sensitivity.	Norepinephrine	33-47	insulin	Homo sapiens	70-77
8189249-3	1994	At the presynaptic level, neuropeptide Y inhibits by 45%, with an EC50 of 50 nM, the potassium-evoked noradrenaline release from pineal nerve endings.	Norepinephrine	102-115	neuropeptide Y	Rattus norvegicus	26-40
8189249-4	1994	This neuropeptide Y inhibition occurs via the activation of pertussis toxin-sensitive G protein-coupled neuropeptide Y-Y2 receptors and is independent from, but additive to, the alpha 2-adrenergic inhibition of noradrenaline release.	Norepinephrine	211-224	neuropeptide Y	Rattus norvegicus	5-19
7914819-5	1994	Examination of monoamine levels and turnover revealed that hotfoot mice had significantly greater concentrations of norepinephrine associated with lower turnover in cerebellum and greater levels of serotonin in cerebellum and striatum, relative to phenotypic controls.	Norepinephrine	116-130	glutamate receptor, ionotropic, delta 2	Mus musculus	59-66
8054249-7	1994	Changes in venous compliance and blood flow were measured by venous occlusion plethysmography using a basal infusion of noradrenaline (1 microgram min-1) to increase venous tone.	Norepinephrine	120-133	CD59 molecule (CD59 blood group)	Homo sapiens	147-152
8069407-8	1994	A decrease in plasma noradrenaline on Losartan suggests a sympathicolytic effect which together with vasodilation may explain the fall in blood pressure and the improvement in insulin sensitivity.	Norepinephrine	21-34	insulin	Homo sapiens	176-183
8069680-4	1994	In contrast, Rp-cAMPS reduced the cAMP-dependent inhibition of IAHP by norepinephrine.	Norepinephrine	71-85	calmodulin 2, pseudogene 1	Rattus norvegicus	16-21
8193992-0	1994	Altered neuropeptide Y effects on noradrenaline levels in the paraventricular nucleus of rats following aortic constriction.	Norepinephrine	34-47	neuropeptide Y	Rattus norvegicus	8-22
8193992-3	1994	Since noradrenaline-containing neurons involved with cardiovascular regulation within the brain are known to coexist with NPY, it is possible that a functional interaction between NPY and noradrenaline exists centrally.	Norepinephrine	6-19	neuropeptide Y	Rattus norvegicus	122-125
8025910-0	1994	Effect of angiotensin II on noradrenaline release in the human forearm.	Norepinephrine	28-41	angiotensinogen	Homo sapiens	10-24
8193992-3	1994	Since noradrenaline-containing neurons involved with cardiovascular regulation within the brain are known to coexist with NPY, it is possible that a functional interaction between NPY and noradrenaline exists centrally.	Norepinephrine	6-19	neuropeptide Y	Rattus norvegicus	180-183
8193992-3	1994	Since noradrenaline-containing neurons involved with cardiovascular regulation within the brain are known to coexist with NPY, it is possible that a functional interaction between NPY and noradrenaline exists centrally.	Norepinephrine	188-201	neuropeptide Y	Rattus norvegicus	122-125
8193992-13	1994	Infusion of NPY resulted in a reduction of noradrenaline concentration in sham animals (P < 0.05), whereas no change in noradrenaline concentration was evident in the aortic-constricted group.	Norepinephrine	43-56	neuropeptide Y	Rattus norvegicus	12-15
7916352-8	1994	In addition, ANP causes vasodilatation and fluid volume reduction by direct actions on vascular smooth muscle cells, and inhibition of secretion of hormones, such as aldosterone, from adrenal cortex and norepinephrine from peripheral adrenergic neurons.	Norepinephrine	203-217	natriuretic peptide A	Homo sapiens	13-16
8168970-0	1994	Noradrenaline inhibits lipopolysaccharide-induced tumor necrosis factor and interleukin 6 production in human whole blood.	Norepinephrine	0-13	interleukin 6	Homo sapiens	76-89
8168970-3	1994	The present study sought insight into the effect of noradrenaline on LPS-induced release of tumor necrosis factor alpha (TNF) and interleukin 6 (IL-6) in human whole blood.	Norepinephrine	52-65	tumor necrosis factor	Homo sapiens	92-119
8168970-3	1994	The present study sought insight into the effect of noradrenaline on LPS-induced release of tumor necrosis factor alpha (TNF) and interleukin 6 (IL-6) in human whole blood.	Norepinephrine	52-65	tumor necrosis factor	Homo sapiens	121-124
8168970-3	1994	The present study sought insight into the effect of noradrenaline on LPS-induced release of tumor necrosis factor alpha (TNF) and interleukin 6 (IL-6) in human whole blood.	Norepinephrine	52-65	interleukin 6	Homo sapiens	130-143
8168970-3	1994	The present study sought insight into the effect of noradrenaline on LPS-induced release of tumor necrosis factor alpha (TNF) and interleukin 6 (IL-6) in human whole blood.	Norepinephrine	52-65	interleukin 6	Homo sapiens	145-149
8168970-5	1994	Noradrenaline caused a dose-dependent inhibition of LPS-induced TNF and IL-6 production.	Norepinephrine	0-13	tumor necrosis factor	Homo sapiens	64-67
8168970-5	1994	Noradrenaline caused a dose-dependent inhibition of LPS-induced TNF and IL-6 production.	Norepinephrine	0-13	interleukin 6	Homo sapiens	72-76
8168970-9	1994	In acute sepsis, enhanced release of noradrenaline may be part of a negative feedback mechanism meant to inhibit ongoing TNF and IL-6 production.	Norepinephrine	37-50	tumor necrosis factor	Homo sapiens	121-124
8168970-9	1994	In acute sepsis, enhanced release of noradrenaline may be part of a negative feedback mechanism meant to inhibit ongoing TNF and IL-6 production.	Norepinephrine	37-50	interleukin 6	Homo sapiens	129-133
7911815-4	1994	Chronic treatment with ACTH in infantile spasms reduces cerebrospinal fluid GABA, beta-endorphin, and somatostatin, increases norepinephrine and tyrosine, and has variable or no effect on homovanillic acid, 3-methoxy-4-hydroxyphenylglycol, 5-hydroxyindoleacetic acid, histamine, and tryptophan.	Norepinephrine	126-140	proopiomelanocortin	Homo sapiens	23-27
8058208-1	1994	Using the in vivo microdialysis method, we have found that at moderate doses (1.44, 3.6 and 7.2 micrograms), corticotropin-releasing factor (CRF) facilitated norepinephrine (NE) release from the dentate gyrus of hippocampus in rats in a dose-response fashion.	Norepinephrine	158-172	corticotropin releasing hormone	Rattus norvegicus	109-139
8006835-4	1994	The purpose of this study is to determine if ACh and VIP cause differential secretion of adrenaline and noradrenaline and whether the differential secretion also occurs when splanchnic nerves are stimulated at different frequencies.	Norepinephrine	104-117	vasoactive intestinal peptide	Rattus norvegicus	53-56
8006835-11	1994	Perfusion with VIP (10 microM for 4 min) resulted in the secretion of 27 ng of catecholamines and the ratio of adrenaline to noradrenaline was 9.7.	Norepinephrine	125-138	vasoactive intestinal peptide	Rattus norvegicus	15-18
8006835-12	1994	A higher concentration of VIP (20 microM for 4 min) resulted in the secretion of greater amounts of catecholamines (102 ng) without significantly altering the ratio of adrenaline to noradrenaline (10.9).	Norepinephrine	182-195	vasoactive intestinal peptide	Rattus norvegicus	26-29
8119144-5	1994	The presence of noradrenaline, a positive control for UCP expression, increased only the level of expression of the 5.5-kb c-erbA alpha-mRNA, but values for nuclear T3-binding capacity similar to those obtained in T3-treated cells were observed.	Norepinephrine	16-29	uncoupling protein 1	Rattus norvegicus	54-57
8119144-5	1994	The presence of noradrenaline, a positive control for UCP expression, increased only the level of expression of the 5.5-kb c-erbA alpha-mRNA, but values for nuclear T3-binding capacity similar to those obtained in T3-treated cells were observed.	Norepinephrine	16-29	thyroid hormone receptor alpha	Rattus norvegicus	123-135
7909929-1	1994	Neuropeptide Y (NPY) is found to be costored with norepinephrine (NE) in vesicles of the nerve terminals.	Norepinephrine	50-64	neuropeptide Y	Rattus norvegicus	0-14
7909929-1	1994	Neuropeptide Y (NPY) is found to be costored with norepinephrine (NE) in vesicles of the nerve terminals.	Norepinephrine	50-64	neuropeptide Y	Rattus norvegicus	16-19
8141282-1	1994	We assessed in normal subjects the effects of an acute increase in forearm norepinephrine (NE) release, evoked by -20 mmHg lower body negative pressure (LBNP), on insulin-mediated muscle glucose uptake.	Norepinephrine	75-89	insulin	Homo sapiens	163-170
8170501-5	1994	As an apparent functional consequence of the decrease in IP3 formation following the TNF alpha exposure, the alpha 1-adrenoceptor-mediated induction of arrhythmias by 100 mumol/l noradrenaline + 10 mumol/l timolol was abolished in TNF alpha-pretreated rat cardiomyocytes.	Norepinephrine	179-192	tumor necrosis factor	Rattus norvegicus	85-94
8170501-5	1994	As an apparent functional consequence of the decrease in IP3 formation following the TNF alpha exposure, the alpha 1-adrenoceptor-mediated induction of arrhythmias by 100 mumol/l noradrenaline + 10 mumol/l timolol was abolished in TNF alpha-pretreated rat cardiomyocytes.	Norepinephrine	179-192	tumor necrosis factor	Rattus norvegicus	231-240
8025910-1	1994	OBJECTIVE: The aim was to test the hypothesis that in normal humans angiotensin II would stimulate local release of noradrenaline under basal conditions or during a sympathetic stimulus provided by lower body negative pressure (LBNP).	Norepinephrine	116-129	angiotensinogen	Homo sapiens	68-82
8017702-7	1994	Arteries exposed to TNF (group 2) had significantly (P = 0.04) decreased maximal relaxation to acetylcholine and increased maximal contraction to norepinephrine, compared with control arteries, but values did not differ from those for arteries of groups 3 and 4.	Norepinephrine	146-160	tumor necrosis factor	Equus caballus	20-23
8144901-0	1994	Endogenous norepinephrine regulates tumor necrosis factor-alpha production from macrophages in vitro.	Norepinephrine	11-25	tumor necrosis factor	Mus musculus	36-63
8144901-12	1994	Therefore, M phi-associated norepinephrine appears to regulate LPS-induced TNF production in an autocrine fashion.	Norepinephrine	28-42	tumor necrosis factor	Mus musculus	75-78
8003768-0	1994	An interleukin-1 beta-induced noradrenaline release in the spleen is mediated by brain corticotropin-releasing factor: an in vivo microdialysis study in conscious rats.	Norepinephrine	30-43	interleukin 1 beta	Rattus norvegicus	3-21
8003768-0	1994	An interleukin-1 beta-induced noradrenaline release in the spleen is mediated by brain corticotropin-releasing factor: an in vivo microdialysis study in conscious rats.	Norepinephrine	30-43	corticotropin releasing hormone	Rattus norvegicus	87-117
8003768-1	1994	The purpose of this study was to investigate whether an intraperitoneal injection of interleukin-1 beta (IL-1 beta) affects noradrenaline release in the spleen through its action on the brain of conscious rats.	Norepinephrine	124-137	interleukin 1 beta	Rattus norvegicus	85-103
8003768-1	1994	The purpose of this study was to investigate whether an intraperitoneal injection of interleukin-1 beta (IL-1 beta) affects noradrenaline release in the spleen through its action on the brain of conscious rats.	Norepinephrine	124-137	interleukin 1 beta	Rattus norvegicus	105-114
8003768-5	1994	The intraperitoneal injection of IL-1 beta (100 ng/kg) produced an immediate and significant increase in the noradrenaline levels in the spleen.	Norepinephrine	109-122	interleukin 1 beta	Rattus norvegicus	33-42
8003768-7	1994	An intracerebroventricular (ICV) injection of a corticotropin-releasing factor (CRF) antagonist (alpha-helical CRF9-41, 30 micrograms) significantly attenuated the IL-1 beta-induced increase in the noradrenaline release.	Norepinephrine	198-211	corticotropin releasing hormone	Rattus norvegicus	48-78
8003768-7	1994	An intracerebroventricular (ICV) injection of a corticotropin-releasing factor (CRF) antagonist (alpha-helical CRF9-41, 30 micrograms) significantly attenuated the IL-1 beta-induced increase in the noradrenaline release.	Norepinephrine	198-211	interleukin 1 beta	Rattus norvegicus	164-173
8003768-9	1994	These results suggest that the intraperitoneal injection of IL-1 beta facilitates noradrenaline release in the spleen through activation of the sympathetic nerve, and the increased sympathetic activity is, at least in part, due to the excitation of neurons containing CRF in the brain.	Norepinephrine	82-95	interleukin 1 beta	Rattus norvegicus	60-69
8174230-2	1994	One role for copper is as a cofactor for dopamine-beta-hydroxylase (DBH), the enzyme that converts dopamine to norepinephrine (NE).	Norepinephrine	111-125	dopamine beta hydroxylase	Mus musculus	41-66
8174230-2	1994	One role for copper is as a cofactor for dopamine-beta-hydroxylase (DBH), the enzyme that converts dopamine to norepinephrine (NE).	Norepinephrine	111-125	dopamine beta hydroxylase	Mus musculus	68-71
8143428-2	1994	The effect of infusion of noradrenaline (0.42 mumol min-1 kg-1) on the exchange of nonesterified fatty acids, glycerol and other metabolites across subcutaneous abdominal adipose tissue was investigated in five healthy subjects using an arteriovenous catheterization technique and measurement of adipose tissue blood flow using the 133Xe clearance technique.	Norepinephrine	26-39	CD59 molecule (CD59 blood group)	Homo sapiens	52-62
8297348-2	1994	Our previous studies have suggested a role for PKC in the regulation of noradrenaline (NA) release from the human neuroblastoma SH-SY5Y.	Norepinephrine	72-85	protein kinase C alpha	Homo sapiens	47-50
8304972-5	1994	The positive inotropic responses to the selective alpha 1-adrenoceptor agonist, phenylephrine, in left ventricular papillary muscles were abolished; the beta 1-adrenoceptor agonist, noradrenaline, was significantly less potent as an inotropic compound in isolated cardiac tissues from hypothyroid rats.	Norepinephrine	182-195	adrenoceptor beta 1	Rattus norvegicus	153-172
8190350-5	1994	Present data support the hypothesis that adrenaline and/or noradrenaline could mediate the effects of both NPY and VIP on aldosterone secretion via beta 1 adrenergic receptors; alternatively, the steroidogenic effect of NPY or VIP could be related to direct interaction between NPY- or VIP-specific binding sites, present on the capsule/glomerular zone of the rat adrenal cortex, and beta 1 adrenergic receptors.	Norepinephrine	59-72	neuropeptide Y	Rattus norvegicus	107-110
8190350-5	1994	Present data support the hypothesis that adrenaline and/or noradrenaline could mediate the effects of both NPY and VIP on aldosterone secretion via beta 1 adrenergic receptors; alternatively, the steroidogenic effect of NPY or VIP could be related to direct interaction between NPY- or VIP-specific binding sites, present on the capsule/glomerular zone of the rat adrenal cortex, and beta 1 adrenergic receptors.	Norepinephrine	59-72	vasoactive intestinal peptide	Rattus norvegicus	115-118
7519697-6	1994	In line with animal studies, vascular angiotensin II increases the vasoconstriction induced by the stimulation of the sympathetic nervous system through the potentiation of noradrenaline release at a presynaptic level, and this effect seems to be mediated by beta-adrenoceptor activation.	Norepinephrine	173-186	angiotensinogen	Homo sapiens	38-52
8055346-1	1994	Noradrenaline (NA) release in the rat lumbar spinal cord (L3-4) in response to variable intensity, selective stimulation of large (A-beta), small myelinated (A-delta), and unmyelinated (C) afferent fibers was examined by in vivo microdialysis with high performance liquid chromatography and electrochemical detection.	Norepinephrine	0-13	galectin 3	Rattus norvegicus	58-62
7957511-3	1994	infusion of a subsystemic dose (average 42 ng.min-1, SD 20.5) of noradrenaline in a dorsal hand vein was begun 1 h before drug treatment.	Norepinephrine	65-78	CD59 molecule (CD59 blood group)	Homo sapiens	46-51
7519690-3	1994	Because insulin is known to stimulate the sympathetic nervous system (SNS), the possibility that insulin-mediated sympathetic stimulation contributed to hypertension in the obese was investigated by the analysis of 24-h urinary norepinephrine (NE) excretion in this group.	Norepinephrine	228-242	insulin	Homo sapiens	97-104
7859095-10	1994	Norepinephrine is suggested to be one signal that triggers cAMP elevation through the beta-adrenergic receptor and thereby affects LC development.	Norepinephrine	0-14	cathelicidin antimicrobial peptide	Homo sapiens	59-63
7721230-0	1994	Intracoronary infusion of bradykinin: effects on noradrenaline overflow following reperfusion of ischemic myocardium in the anesthetized dog.	Norepinephrine	49-62	kininogen 1	Canis lupus familiaris	26-36
7721230-1	1994	OBJECTIVE: The aim of this study was to investigate the effects of intracoronary bradykinin (BK) infusion on noradrenaline release and ventricular arrhythmias induced by coronary occlusion and reperfusion in the anesthetized dog.	Norepinephrine	109-122	kininogen 1	Canis lupus familiaris	81-91
7721230-1	1994	OBJECTIVE: The aim of this study was to investigate the effects of intracoronary bradykinin (BK) infusion on noradrenaline release and ventricular arrhythmias induced by coronary occlusion and reperfusion in the anesthetized dog.	Norepinephrine	109-122	kininogen 1	Canis lupus familiaris	93-95
7721230-6	1994	RESULTS: BK significantly reduced the amount of noradrenaline released at reperfusion by ischemic myocardium (from 82.1 +/- 31.7 to 11.9 +/- 9.6 ng.min-1), as well as plasma creatine kinase activity at 30 min of reperfusion.	Norepinephrine	48-61	kininogen 1	Canis lupus familiaris	9-11
7721230-8	1994	CONCLUSION: This suggests that the protective effect of bradykinin against reperfusion-induced sustained ventricular tachycardia could be associated with a reduction in cardiac noradrenaline release.	Norepinephrine	177-190	kininogen 1	Canis lupus familiaris	56-66
7842240-4	1994	It was found that women chronically exposed to CS2 showed significantly lower levels of dopamine and lower activities of DBH (p < 0.001), significantly lower urinary excretion of adrenaline (p < 0.001), but insignificantly lower excretion of noradrenaline and vanillylmandelic acid.	Norepinephrine	248-261	chorionic somatomammotropin hormone 2	Homo sapiens	47-50
8157942-4	1994	METHODS: Noradrenaline-induced vasoconstriction was measured in helical de-endothelialized rat aortic strips following 2-5 h exposure to one or more of: carbenoxolone, corticosterone, a mineralocorticoid-receptor antagonist (spironolactone) and a glucocorticoid- and progesterone-receptor antagonist (RU 38486).	Norepinephrine	9-22	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	186-212
7525980-4	1994	After that the cell began to extend and the contraction of these cells can be induced by the presence of 10(-2) mmol/L endothelin-1, 1 mmol/L of substance P and 2 x 10(-5) mmol/L noradrenalin.	Norepinephrine	179-191	tachykinin precursor 1	Homo sapiens	145-162
8015353-6	1994	We suggest that the ability of neuropeptide Y to augment norepinephrine-induced contraction of the rat tail artery is due, at least in part, to the ability of neuropeptide Y to increase norepinephrine-stimulated phospholipase C activity in vascular smooth muscle and may represent the mechanism of action of this co-neurotransmitter in vivo.	Norepinephrine	57-71	neuropeptide Y	Rattus norvegicus	31-45
8015353-6	1994	We suggest that the ability of neuropeptide Y to augment norepinephrine-induced contraction of the rat tail artery is due, at least in part, to the ability of neuropeptide Y to increase norepinephrine-stimulated phospholipase C activity in vascular smooth muscle and may represent the mechanism of action of this co-neurotransmitter in vivo.	Norepinephrine	57-71	neuropeptide Y	Rattus norvegicus	159-173
8015353-6	1994	We suggest that the ability of neuropeptide Y to augment norepinephrine-induced contraction of the rat tail artery is due, at least in part, to the ability of neuropeptide Y to increase norepinephrine-stimulated phospholipase C activity in vascular smooth muscle and may represent the mechanism of action of this co-neurotransmitter in vivo.	Norepinephrine	186-200	neuropeptide Y	Rattus norvegicus	31-45
8015353-6	1994	We suggest that the ability of neuropeptide Y to augment norepinephrine-induced contraction of the rat tail artery is due, at least in part, to the ability of neuropeptide Y to increase norepinephrine-stimulated phospholipase C activity in vascular smooth muscle and may represent the mechanism of action of this co-neurotransmitter in vivo.	Norepinephrine	186-200	neuropeptide Y	Rattus norvegicus	159-173
8015353-0	1994	Neuropeptide Y potentiates norepinephrine-stimulated inositol phosphate production in the rat tail artery.	Norepinephrine	27-41	neuropeptide Y	Rattus norvegicus	0-14
8015353-1	1994	We have recently demonstrated the ability of neuropeptide Y to augment norepinephrine-stimulated contractions of the rat tail artery.	Norepinephrine	71-85	neuropeptide Y	Rattus norvegicus	45-59
8015353-5	1994	When neuropeptide Y and norepinephrine were added together, the norepinephrine-stimulated increase in [3H]inositol 1,4,5-trisphosphate was significantly augmented (467 +/- 35% of control) as was the increase measured in total [3H]inositol phosphates (366 +/- 21% of control).	Norepinephrine	64-78	neuropeptide Y	Rattus norvegicus	5-19
7997146-9	1994	The daily excretion of adrenaline and noradrenaline in urine and concentrations of dopamine in plasma of women chronically exposed to CS2 were lower (p < 0.001), while the concentrations of serotonin and prolactin in plasma were higher (p < 0.001).	Norepinephrine	38-51	chorionic somatomammotropin hormone 2	Homo sapiens	134-137
8165213-0	1994	[Effect of steroid hormones and noradrenaline on somatotropin hormone secretion by primary cultures of hypophyseal cells of rats of various ages].	Norepinephrine	32-45	growth hormone 1	Rattus norvegicus	49-61
8159777-4	1994	We have used a novel cDNA expression cloning strategy to isolate cDNAs for the antidepressant-sensitive serotonin transporter and for a reserpine-sensitive vesicular monoamine transporter which is critical for packaging serotonin, dopamine, norepinephrine, epinephrine and histamine into synaptic vesicles and secretory granules.	Norepinephrine	241-255	solute carrier family 6 member 4	Homo sapiens	104-125
8066344-4	1994	Endothelin-1 (ET) is equipotent as a vasoconstrictor in arteries and veins, with a potency at least 10 to 100-fold that of noradrenaline (NA) or serotonin (5-HT).	Norepinephrine	123-136	endothelin 1	Homo sapiens	0-12
8124409-1	1993	We previously showed that intravenous insulin increased plasma noradrenaline during euglycemia and without concomitant changes in plasma adrenaline.	Norepinephrine	63-76	insulin	Homo sapiens	38-45
7531843-1	1994	The 29 amino acid peptide galanin (GAL) coexists with norepinephrine in rat locus coeruleus (LC) neurons to a remarkably high degree.	Norepinephrine	54-68	galanin and GMAP prepropeptide	Rattus norvegicus	26-33
7531843-1	1994	The 29 amino acid peptide galanin (GAL) coexists with norepinephrine in rat locus coeruleus (LC) neurons to a remarkably high degree.	Norepinephrine	54-68	galanin and GMAP prepropeptide	Rattus norvegicus	35-38
7907499-1	1993	Neuropeptide Y (NPY) is a sympathetic cotransmitter and a platelet-derived factor which causes vasoconstriction, potentiation of norepinephrine (NE) action, and vascular mitogenic effects.	Norepinephrine	129-143	neuropeptide Y	Rattus norvegicus	0-14
7905857-1	1993	The norepinephrine transporter protein (NET) is the presynaptic reuptake site for norepinephrine and a site of action for several drugs with CNS effects, some of which are therapeutically useful and some of which are drugs of abuse.	Norepinephrine	4-18	solute carrier family 6 member 2	Homo sapiens	40-43
8145155-11	1993	The depolarization-induced [Ca2+]i rise was shortened and reduced in amplitude after noradrenaline- (NA 10 microM) or caffeine- (5 mM) induced release of Ca2+ store and when the patch pipette solution contained ryanodine (100 microM).	Norepinephrine	85-98	carbonic anhydrase 2	Rattus norvegicus	28-31
8145155-11	1993	The depolarization-induced [Ca2+]i rise was shortened and reduced in amplitude after noradrenaline- (NA 10 microM) or caffeine- (5 mM) induced release of Ca2+ store and when the patch pipette solution contained ryanodine (100 microM).	Norepinephrine	85-98	carbonic anhydrase 2	Rattus norvegicus	154-157
8125855-5	1993	The effect of rTNF-alpha on vasoconstriction in response to norepinephrine (NE) was a dramatic reduction after 2 h of exposure to 1 ng/ml rTNF-alpha.	Norepinephrine	60-74	tumor necrosis factor	Rattus norvegicus	14-24
7907499-1	1993	Neuropeptide Y (NPY) is a sympathetic cotransmitter and a platelet-derived factor which causes vasoconstriction, potentiation of norepinephrine (NE) action, and vascular mitogenic effects.	Norepinephrine	129-143	neuropeptide Y	Rattus norvegicus	16-19
8125855-5	1993	The effect of rTNF-alpha on vasoconstriction in response to norepinephrine (NE) was a dramatic reduction after 2 h of exposure to 1 ng/ml rTNF-alpha.	Norepinephrine	60-74	tumor necrosis factor	Rattus norvegicus	138-148
8293299-2	1993	administration of corticotropin-releasing factor (CRF) antagonist, alpha-helical CRF9-41 (ahCRF), on increases in noradrenaline (NA) turnover caused by immobilization stress in rat brain regions.	Norepinephrine	114-127	corticotropin releasing hormone	Rattus norvegicus	18-48
8237747-5	1993	Among patients with a first myocardial infarction, a positive correlation was found between infarct size and ANP, angiotensin II, and norepinephrine on day 5 to 7 and between infarct size and angiotensin II during head-up tilt at 1 month, and between infarct size and ANP at 1 month.	Norepinephrine	134-148	natriuretic peptide A	Homo sapiens	109-112
8298811-17	1993	Noradrenaline infusion (620-820 ng kg-1 min-1) potentiated the permeability action of ET-1(1 nmol kg-1) in the pulmonary circulation, whereas it did not modify ET-1-induced protein extravasation in the other vascular beds.7.	Norepinephrine	0-13	endothelin 1	Rattus norvegicus	86-90
8293770-2	1993	Since all three peptides are able to modulate catecholamine release, a change in noradrenaline and adrenaline release should be expected when angiotensin I converting enzyme (kininase II) is inhibited.	Norepinephrine	81-94	angiotensinogen	Homo sapiens	142-155
8293770-2	1993	Since all three peptides are able to modulate catecholamine release, a change in noradrenaline and adrenaline release should be expected when angiotensin I converting enzyme (kininase II) is inhibited.	Norepinephrine	81-94	angiotensin I converting enzyme	Homo sapiens	175-186
8293770-6	1993	Whereas Ang I exerted no facilitating action on noradrenaline, bradykinin stimulated noradrenaline release dose-dependently, almost during converting enzyme inhibition.	Norepinephrine	85-98	kininogen 1	Homo sapiens	63-73
8241363-1	1993	The hypothesis that neuropeptide Y (NPY) potentiates noradrenaline (NA)-induced vascular force development by increasing free intracellular Ca2+ ([Ca2+]i) was tested in rat mesenteric resistance arteries.	Norepinephrine	53-66	neuropeptide Y	Rattus norvegicus	20-34
8246129-4	1993	injections of ANG II (100 ng) selectively increased the release of norepinephrine (NA) from the SON.	Norepinephrine	67-81	angiotensinogen	Rattus norvegicus	14-20
8241363-1	1993	The hypothesis that neuropeptide Y (NPY) potentiates noradrenaline (NA)-induced vascular force development by increasing free intracellular Ca2+ ([Ca2+]i) was tested in rat mesenteric resistance arteries.	Norepinephrine	53-66	neuropeptide Y	Rattus norvegicus	36-39
7902747-4	1993	Analysis of the individual metabolites of inositol phospholipid metabolism formed in response to noradrenaline in PKC-depleted astrocytes revealed potentiated accumulations of radiolabelled glycerophosphoinositol (GPI), inositol monophosphate (IP1) and inositol bisphosphate (IP2) but not inositol trisphosphate (IP3) when compared to controls.	Norepinephrine	97-110	proline rich transmembrane protein 2	Homo sapiens	114-117
7902747-3	1993	Noradrenaline-, ATP-, histamine- and glutamate-evoked [3H]-inositol phosphate accumulations were potentiated to varying degrees in PKC-depleted cultures whilst those evoked by carbachol and NaF were reduced and unchanged respectively.	Norepinephrine	0-13	proline rich transmembrane protein 2	Homo sapiens	131-134
8275307-0	1993	Age-related changes of noradrenergic-NPY interaction in rat brain: norepinephrine, NPY levels and alpha-adrenoceptors.	Norepinephrine	67-81	neuropeptide Y	Rattus norvegicus	37-40
7902747-3	1993	Noradrenaline-, ATP-, histamine- and glutamate-evoked [3H]-inositol phosphate accumulations were potentiated to varying degrees in PKC-depleted cultures whilst those evoked by carbachol and NaF were reduced and unchanged respectively.	Norepinephrine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	190-193
8114953-3	1993	beta 1-adrenoceptors were activated by (-)-noradrenaline during beta 2-adrenoceptor blockade with 50 nmol/l ICI 118551.	Norepinephrine	39-56	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	0-6
8114954-0	1993	Neuropeptide Y potentiates via Y2-receptors the inhibitory effect of noradrenaline in rat locus coeruleus neurones.	Norepinephrine	69-82	neuropeptide Y	Rattus norvegicus	0-14
8114954-3	1993	Neuropeptide Y (NPY), its C-terminal fragment NPY (16-36) and peptide YY (PYY), at a concentration of 0.1 mumol/l all, potentiated the effect of noradrenaline, while [Leu31, Pro34]NPY (0.1 mumol/l) was inactive.	Norepinephrine	145-158	neuropeptide Y	Rattus norvegicus	0-14
8114954-3	1993	Neuropeptide Y (NPY), its C-terminal fragment NPY (16-36) and peptide YY (PYY), at a concentration of 0.1 mumol/l all, potentiated the effect of noradrenaline, while [Leu31, Pro34]NPY (0.1 mumol/l) was inactive.	Norepinephrine	145-158	neuropeptide Y	Rattus norvegicus	16-19
8114954-3	1993	Neuropeptide Y (NPY), its C-terminal fragment NPY (16-36) and peptide YY (PYY), at a concentration of 0.1 mumol/l all, potentiated the effect of noradrenaline, while [Leu31, Pro34]NPY (0.1 mumol/l) was inactive.	Norepinephrine	145-158	neuropeptide Y	Rattus norvegicus	46-49
8114954-3	1993	Neuropeptide Y (NPY), its C-terminal fragment NPY (16-36) and peptide YY (PYY), at a concentration of 0.1 mumol/l all, potentiated the effect of noradrenaline, while [Leu31, Pro34]NPY (0.1 mumol/l) was inactive.	Norepinephrine	145-158	neuropeptide Y	Rattus norvegicus	46-49
8222516-4	1993	Noradrenaline infusion rates ranged from 0.015 to 0.075 microgram min-1 kg-1.	Norepinephrine	0-13	CD59 molecule (CD59 blood group)	Homo sapiens	66-76
7905536-7	1993	In contrast to beta-adrenergic stimulation, alpha-adrenoceptor stimulation with phenylephrine and norepinephrine caused the induction of c-jun and Egr-1 in addition to the proto-oncogenes induced by isoproterenol.	Norepinephrine	98-112	early growth response 1	Rattus norvegicus	147-152
8222516-14	1993	The renin-angiotensin-aldosterone axis was stimulated by noradrenaline in both euhydrated and overhydrated subjects.	Norepinephrine	57-70	renin	Homo sapiens	4-9
8406664-1	1993	Evidence supports the hypothesis that an impaired capacity of insulin to antagonize norepinephrine-induced vasoconstriction increases alpha-adrenergic tone in overweight young men with insulin resistance and mild hypertension.	Norepinephrine	84-98	insulin	Homo sapiens	62-69
8406664-1	1993	Evidence supports the hypothesis that an impaired capacity of insulin to antagonize norepinephrine-induced vasoconstriction increases alpha-adrenergic tone in overweight young men with insulin resistance and mild hypertension.	Norepinephrine	84-98	insulin	Homo sapiens	185-192
7904926-2	1993	Atrial natriuretic factor effects on neuronal noradrenaline release evoked by angiotensin II or III and high potassium solution plus angiotensin II and III in the rat hypothalamus were studied.	Norepinephrine	46-59	angiotensinogen	Rattus norvegicus	78-92
8277975-0	1993	Facilitatory and inhibitory modulation by endogenous adenosine of noradrenaline release in the epididymal portion of rat vas deferens.	Norepinephrine	66-79	arginine vasopressin	Rattus norvegicus	121-124
7904926-5	1993	On the other hand, the atrial factor diminished the increase of noradrenaline release induced by both angiotensin II (1 microM) or angiotensin III (1 microM).	Norepinephrine	64-77	angiotensinogen	Rattus norvegicus	102-116
7904926-11	1993	Our results suggest that atrial natriuretic factor effects on noradrenaline release, evoked by angiotensin II, III and KCl, may be involved in the regulation of the central catecholamine pathways and sympathetic activity.	Norepinephrine	62-75	angiotensinogen	Rattus norvegicus	95-109
7904926-0	1993	Atrial natriuretic factor inhibits noradrenaline release in the presence of angiotensin II and III in the rat hypothalamus.	Norepinephrine	35-48	angiotensinogen	Rattus norvegicus	76-98
8277975-1	1993	The present study aimed at determining the modulation by adenosine of the release of noradrenaline in the epididymal portion of the rat vas deferens.	Norepinephrine	85-98	arginine vasopressin	Rattus norvegicus	136-139
8371140-1	1993	Neuropeptide Y (NPY) is a 36-amino acid peptide that is colocalized and released with norepinephrine (NE) from central and peripheral adrenergic neurons and has been suggested to contribute to the control of vascular tone.	Norepinephrine	86-100	neuropeptide Y	Rattus norvegicus	0-14
8214124-2	1993	Because norepinephrine, contained within central neurons involved in cardiovascular sympathetic regulation, is known to coexist with neuropeptide Y, it is possible that a functional interaction between neuropeptide Y and norepinephrine exists within the brain.	Norepinephrine	8-22	neuropeptide Y	Rattus norvegicus	202-216
8214124-2	1993	Because norepinephrine, contained within central neurons involved in cardiovascular sympathetic regulation, is known to coexist with neuropeptide Y, it is possible that a functional interaction between neuropeptide Y and norepinephrine exists within the brain.	Norepinephrine	221-235	neuropeptide Y	Rattus norvegicus	133-147
8371140-1	1993	Neuropeptide Y (NPY) is a 36-amino acid peptide that is colocalized and released with norepinephrine (NE) from central and peripheral adrenergic neurons and has been suggested to contribute to the control of vascular tone.	Norepinephrine	86-100	neuropeptide Y	Rattus norvegicus	16-19
8405129-0	1993	D-myo-inositol 1,2,6-trisphosphate blocks neuropeptide Y-induced facilitation of noradrenaline-evoked vasoconstriction of the mesenteric bed.	Norepinephrine	81-94	neuropeptide Y	Rattus norvegicus	42-56
8254175-10	1993	Furthermore, alpha-trinositol treatment completely inhibited the potentiation induced by neuropeptide Y (0.1 micrograms/min for 30 min) of the blood pressure responses to intravenous bolus injections of noradrenaline (20 ng), tyramine (40 micrograms) or angiotensin II (10 ng).	Norepinephrine	203-216	neuropeptide Y	Rattus norvegicus	89-103
8254175-10	1993	Furthermore, alpha-trinositol treatment completely inhibited the potentiation induced by neuropeptide Y (0.1 micrograms/min for 30 min) of the blood pressure responses to intravenous bolus injections of noradrenaline (20 ng), tyramine (40 micrograms) or angiotensin II (10 ng).	Norepinephrine	203-216	angiotensinogen	Rattus norvegicus	254-268
8405129-2	1993	While perfusion with 0.1 nM neuropeptide Y significantly increased the maximal noradrenaline-evoked vasoconstriction without modifying its EC50, 10 nM neuropeptide Y potentiated the maximal noradrenaline effect and significantly shifted its concentration-response curve to the left.	Norepinephrine	79-92	neuropeptide Y	Rattus norvegicus	28-42
8405129-2	1993	While perfusion with 0.1 nM neuropeptide Y significantly increased the maximal noradrenaline-evoked vasoconstriction without modifying its EC50, 10 nM neuropeptide Y potentiated the maximal noradrenaline effect and significantly shifted its concentration-response curve to the left.	Norepinephrine	190-203	neuropeptide Y	Rattus norvegicus	151-165
8405129-3	1993	Perfusion with 1-10 microM D-myo-inositol 1,2,6-trisphosphate (alpha-trinositol) reduced, in a concentration-dependent fashion, the neuropeptide Y-induced potentiation of the noradrenaline-evoked vasoconstriction without altering the potency or maximal response evoked by the catecholamine alone.	Norepinephrine	175-188	neuropeptide Y	Rattus norvegicus	132-146
8405129-4	1993	Perfusion with 0.1 nM neuropeptide Y plus 1 microM alpha-trinositol completely abolished the neuropeptide Y-induced facilitation of the noradrenaline effect.	Norepinephrine	136-149	neuropeptide Y	Rattus norvegicus	22-36
7692123-3	1993	The contractile force induced by 10(-6) M ET-1 was approximately 30% of that induced by 3 x 10(-5) M carbachol in detrusor muscle strips, approximately 40% of that induced by 10(-4) M norepinephrine in spermatic cord muscle strips and almost equal to that induced by 10(-5) M phenylephrine in prostatic adenoma muscle strips.	Norepinephrine	184-198	endothelin 1	Homo sapiens	42-46
8405129-4	1993	Perfusion with 0.1 nM neuropeptide Y plus 1 microM alpha-trinositol completely abolished the neuropeptide Y-induced facilitation of the noradrenaline effect.	Norepinephrine	136-149	neuropeptide Y	Rattus norvegicus	93-107
8405129-1	1993	Perfusion of the rat mesenteric bed with 0.1 or 10 nM neuropeptide Y potentiated the noradrenaline-induced increase in mesenteric pressure; the peptide did not modify basal perfusion pressure.	Norepinephrine	85-98	neuropeptide Y	Rattus norvegicus	54-68
8405129-5	1993	alpha-Trinositol 1 microM in the presence of 10 nM neuropeptide Y caused a nonparallel rightward shift of the noradrenaline concentration-response curve as compared to that obtained in the presence of 10 nM neuropeptide Y alone.	Norepinephrine	110-123	neuropeptide Y	Rattus norvegicus	51-65
8376550-0	1993	Norepinephrine and vasoactive intestinal peptide induce IL-6 secretion by astrocytes: synergism with IL-1 beta and TNF alpha.	Norepinephrine	0-14	interleukin 6	Rattus norvegicus	56-60
8038024-7	1993	MAIN OUTCOME MEASURES: Changes in TNF alpha and the correlation with changes in plasma noradrenaline, plasma renin activity, and weight during optimal medical treatment for one year.	Norepinephrine	87-100	tumor necrosis factor	Homo sapiens	34-43
8254520-4	1993	Infusions of VIP at a dose of 0.13 micrograms min-1 kg-1 caused a small, but significant increase in adrenaline and noradrenaline output which was, however, far below the level recorded previously in response to acetylcholine (0.7 micrograms min-1 kg-1).	Norepinephrine	116-129	vasoactive intestinal peptide	Bos taurus	13-16
8393485-0	1993	Interleukin-1 beta augments release of norepinephrine, dopamine, and serotonin in the rat anterior hypothalamus.	Norepinephrine	39-53	interleukin 1 beta	Rattus norvegicus	0-18
8393485-3	1993	IL-1 beta (1 ng) injected directly into the AHY elicited release of norepinephrine (NE), dopamine (DA), and 5-HT, as well as increases in their metabolites, 4-hydroxy-3-methoxyphenylglycol, 3,4-dihydroxyphenylacetic acid, 4-hydroxy-3-methoxyphenylacetic acid, and 5-hydroxyindole-3-acetic acid, in the AHY.	Norepinephrine	68-82	interleukin 1 beta	Rattus norvegicus	0-9
8342501-8	1993	Comparison of patients subdivided according to median hormone levels (ANF, 30.3 pmol/liter; norepinephrine, 2.29 nmol/liter) demonstrated a significantly increased mortality rate in patients with elevated ANF (p < 0.001), but not elevated norepinephrine levels.	Norepinephrine	92-106	natriuretic peptide A	Homo sapiens	205-208
8342501-8	1993	Comparison of patients subdivided according to median hormone levels (ANF, 30.3 pmol/liter; norepinephrine, 2.29 nmol/liter) demonstrated a significantly increased mortality rate in patients with elevated ANF (p < 0.001), but not elevated norepinephrine levels.	Norepinephrine	242-256	natriuretic peptide A	Homo sapiens	205-208
7691355-1	1993	Chromogranin A (CGA) is a member of a family of highly acidic proteins co-stored and co-secreted with adrenaline and noradrenaline in the adrenal medulla.	Norepinephrine	117-130	chromogranin A	Bos taurus	0-14
8376550-0	1993	Norepinephrine and vasoactive intestinal peptide induce IL-6 secretion by astrocytes: synergism with IL-1 beta and TNF alpha.	Norepinephrine	0-14	interleukin 1 beta	Rattus norvegicus	101-110
8376550-0	1993	Norepinephrine and vasoactive intestinal peptide induce IL-6 secretion by astrocytes: synergism with IL-1 beta and TNF alpha.	Norepinephrine	0-14	tumor necrosis factor	Rattus norvegicus	115-124
8376550-5	1993	Norepinephrine (NE) and the beta-adrenergic agonist isoproterenol (IPT) induced IL-6 secretion in a dose-dependent fashion.	Norepinephrine	0-14	interleukin 6	Rattus norvegicus	80-84
8393790-6	1993	The results obtained demonstrate that physiological doses of norepinephrine do not modify malic-enzyme mRNA levels when acting alone, but considerably reduce the induction produced by insulin, 3,5,3"-triiodothyronine or both together.	Norepinephrine	61-75	insulin	Homo sapiens	184-191
8349004-12	1993	In the brain, there is good evidence that locally generated angiotensin II causes release of norepinephrine that in turn stimulates gonadotropin-releasing hormone-secreting neurons, increasing circulating luteinizing hormone.	Norepinephrine	93-107	angiotensinogen	Rattus norvegicus	60-74
8338156-5	1993	Pretreatment of intact rats with corticosterone virtually abolished the UCP mRNA response to cold and norepinephrine (NE).	Norepinephrine	102-116	uncoupling protein 1	Rattus norvegicus	72-75
8392281-7	1993	Further, vascular function was improved not only after high-dose, but also after low-dose ACE inhibitor treatment, as tested in the aortic vessels: an inhibition of vascular ACE was associated with attenuated vasoconstrictor responses to norepinephrine and enhanced dilator responses to acetylcholine.	Norepinephrine	238-252	angiotensin I converting enzyme	Rattus norvegicus	90-93
8104166-3	1993	Norepinephrine (NE) also modulated chemiluminescence (CL) emission of J774 cells, with dose-dependent suppression of CL dependent upon co-incubation with gamma-interferon (gamma-INF).	Norepinephrine	0-14	interferon gamma	Mus musculus	154-170
8104166-3	1993	Norepinephrine (NE) also modulated chemiluminescence (CL) emission of J774 cells, with dose-dependent suppression of CL dependent upon co-incubation with gamma-interferon (gamma-INF).	Norepinephrine	0-14	interferon gamma	Mus musculus	172-181
8323563-0	1993	Participation of poly(ADP-ribose) synthetase in the process of norepinephrine-induced inhibition of major histocompatibility complex class II antigen expression in human astrocytoma cells.	Norepinephrine	63-77	poly(ADP-ribose) polymerase 1	Homo sapiens	17-44
8323563-2	1993	In the present study, we found that addition of norepinephrine to the cultured human astrocytoma STTG1 cells induced mRNA of poly(ADP-ribose) synthetase in 6-14h.	Norepinephrine	48-62	poly(ADP-ribose) polymerase 1	Homo sapiens	125-152
8323563-5	1993	These results suggest that an increase of poly(ADP-ribose) synthetase by norepinephrine cause the inhibition of interferon-gamma-mediated MHC class II antigen expression.	Norepinephrine	73-87	poly(ADP-ribose) polymerase 1	Homo sapiens	42-69
8323563-5	1993	These results suggest that an increase of poly(ADP-ribose) synthetase by norepinephrine cause the inhibition of interferon-gamma-mediated MHC class II antigen expression.	Norepinephrine	73-87	interferon gamma	Homo sapiens	112-128
8406322-13	1993	In the whole group of patients, independently from fat distribution, significant correlations were found between the incremental areas of the plasma insulin curve during OGTT and the noradrenaline an isoprenaline induced lipolytic activities both in omental and epigastric adipose tissue.	Norepinephrine	183-196	insulin	Homo sapiens	149-156
8315492-6	1993	MIBG uptake in hNET transfected cells is inhibited by 3 x 10(-6) M norepinephrine (87% inhibition) and by hNET transport inhibitors: 10(-7) M desipramine (94% inhibition) and 10(-7) M mazindol (97% inhibition).	Norepinephrine	67-81	solute carrier family 6 member 2	Homo sapiens	15-19
8392281-7	1993	Further, vascular function was improved not only after high-dose, but also after low-dose ACE inhibitor treatment, as tested in the aortic vessels: an inhibition of vascular ACE was associated with attenuated vasoconstrictor responses to norepinephrine and enhanced dilator responses to acetylcholine.	Norepinephrine	238-252	angiotensin I converting enzyme	Rattus norvegicus	174-177
8390835-4	1993	The selective beta 1-adrenoceptor agonist, noradrenaline, was less potent in isolated right atria from dwarf rats although maximal responses were unchanged.	Norepinephrine	43-56	adrenoceptor beta 1	Rattus norvegicus	14-33
8358534-21	1993	Studies in rats, in which the noradrenaline isomer 6-hydroxydopamine was used, suggested that the post synaptic uptake process is operative in hypothalamic CRH and vasopressin neurones in vivo.11.	Norepinephrine	30-43	corticotropin releasing hormone	Rattus norvegicus	156-159
8347895-0	1993	Splenic norepinephrine is decreased in MRL-lpr/lpr mice.	Norepinephrine	8-22	Fas (TNF receptor superfamily member 6)	Mus musculus	43-46
8499491-4	1993	Treatment of the cells with 10(-6) M bradykinin exhausts calcium release such that the successive treatment of the cells with norepinephrine, carbachol, or serotonin results in no secondary response.	Norepinephrine	126-140	kininogen 1	Homo sapiens	37-47
8499491-5	1993	In contrast, bradykinin treatment of the cells following exposure to norepinephrine, carbachol, or serotonin caused a secondary increase in calcium release.	Norepinephrine	69-83	kininogen 1	Homo sapiens	13-23
8347895-0	1993	Splenic norepinephrine is decreased in MRL-lpr/lpr mice.	Norepinephrine	8-22	Fas (TNF receptor superfamily member 6)	Mus musculus	47-50
8500726-8	1993	Intravenous infusion of VIP and norepinephrine inhibited CCK-induced gallbladder contraction and these responses were abolished dose dependently by intravenous infusion of (4Cl-D-Phe6-Leu17)VIP and phentolamine, respectively.	Norepinephrine	32-46	vasoactive intestinal peptide	Canis lupus familiaris	190-193
8347895-5	1993	Norepinephrine content is reduced in MRL-lpr/lpr male and female mice prior to the onset of observed splenomegaly and remains reduced at all ages examined.	Norepinephrine	0-14	Fas (TNF receptor superfamily member 6)	Mus musculus	41-44
8347895-5	1993	Norepinephrine content is reduced in MRL-lpr/lpr male and female mice prior to the onset of observed splenomegaly and remains reduced at all ages examined.	Norepinephrine	0-14	Fas (TNF receptor superfamily member 6)	Mus musculus	45-48
8327547-1	1993	The effect of corticotropin-releasing factor (CRF) on central noradrenaline (NA) metabolism was examined by measuring levels of the major metabolite of NA, 3-methoxy-4-hydroxy-phenylethyleneglycol sulfate (MHPG-SO4) in several rat brain regions.	Norepinephrine	62-75	corticotropin releasing hormone	Rattus norvegicus	14-44
8392517-0	1993	Interleukin-6 production by astrocytes: induction by the neurotransmitter norepinephrine.	Norepinephrine	74-88	interleukin 6	Rattus norvegicus	0-13
8392517-4	1993	We have investigated the possibility that a constitutively present endogenous factor, the neurotransmitter norepinephrine (NE), can induce astrocyte IL-6 production.	Norepinephrine	107-121	interleukin 6	Rattus norvegicus	149-153
7687721-5	1993	Second, in aortic rings tonically contracted by 1 microM norepinephrine (NE) in the presence of 1 microM nifedipine, i.e., in rings contracted mainly owing to NE-stimulated Ca2+ entry through receptor-operated channels, (-)-cromakalim induced relaxation with an EC50 of 0.68 microM and exhibited a 191-fold higher potency than the (+)-enantiomer.	Norepinephrine	57-71	carbonic anhydrase 2	Oryctolagus cuniculus	173-176
8396061-0	1993	Effect of naringin and naringenin on contractions induced by noradrenaline in rat vas deferens--I.	Norepinephrine	61-74	arginine vasopressin	Rattus norvegicus	82-85
7688893-7	1993	Noradrenaline (10 microM) exhibited different actions on the various HVA current components: (1) it prolonged the activation kinetics of omega-CgTx-sensitive currents, (2) it depressed by about 20% the size of DHP-sensitive currents, and (3) it had little or no effects on the residual DHP- and omega-CgTx-resistant current although intracellularly applied guanosine 5"-O-(3-thiotriphosphate) (GTP-gamma-S) prolonged its activation time course.	Norepinephrine	0-13	dihydropyrimidinase	Homo sapiens	286-289
8485825-4	1993	In particular, the following questions were addressed: 1) Is the facilitation of noradrenaline release in the genesis of arrhythmias a target for ACE inhibition?	Norepinephrine	81-94	angiotensin I converting enzyme	Homo sapiens	146-149
8491502-11	1993	Phasic electrical stimulation induced release of norepinephrine; this was inhibited by endothelin-1 at high concentrations (4 x 10(-7) M) in the presence of atropine.	Norepinephrine	49-63	endothelin 1	Canis lupus familiaris	87-99
8486891-5	1993	Treatment with the synthetic amino acid, DL-threo-dihydroxyphenylserine, which is converted to noradrenaline by dopa-decarboxylase, resulted in a significant increase in blood pressure.	Norepinephrine	95-108	dopa decarboxylase	Homo sapiens	112-130
8496333-3	1993	In addition, plasma cortisol and norepinephrine were also increased in the high insulin study (by 19% and 24% respectively, p < 0.01, for both).	Norepinephrine	33-47	insulin	Homo sapiens	80-87
15278468-5	1993	There was a significant positive correlation between plasma renin and aldosterone (r = 0.56, P < 0.01) levels in non-cirrhotics, but no correlation was observed in cirrhotics; and there was a significant positive correlation between plasma norepinephrine and arginine vasopressin (r = 0.45, P < 0.05) levels in non-cirrhotics, but no correlation in cirrhotics.	Norepinephrine	243-257	renin	Homo sapiens	60-65
8335573-10	1993	The effect of TNF-alpha was specific for release of NO from the endothelium of BPA because TNF-alpha did not affect 1) EDR of BPV to ACh, BK, or ATP; 2) EIR of BPA or BPV to nitroprusside; and 3) contraction of either BPA or BPV to KCl, U-46619, histamine, norepinephrine, or serotonin.	Norepinephrine	257-271	tumor necrosis factor	Homo sapiens	14-23
8518923-0	1993	Norepinephrine injections in diagonal band of Broca selectively reduced the activity of vasopressin supraoptic neurons in the rat.	Norepinephrine	0-14	arginine vasopressin	Rattus norvegicus	88-99
8518923-3	1993	The present study evaluated whether injections of norepinephrine into the diagonal band of Broca affect the spontaneous activity of supraoptic vasopressin-secreting neurons.	Norepinephrine	50-64	arginine vasopressin	Rattus norvegicus	143-154
8518923-5	1993	Injections of 200 nl of 10 microM norepinephrine into the diagonal band of Broca region arrested the spontaneous activity of 80% (12/15) of vasopressin-secreting neurons but only 7% (1/14) of oxytocin secreting-neurons demonstrated a comparable decrease in excitability.	Norepinephrine	34-48	arginine vasopressin	Rattus norvegicus	140-151
8477561-3	1993	Angiotensin II increased significantly in response to infused norepinephrine during placebo administration (p < 0.001) but not during captopril administration (p = 0.15).	Norepinephrine	62-76	angiotensinogen	Homo sapiens	0-14
8384645-2	1993	BACKGROUND: Angiotensin II has been shown experimentally to stimulate norepinephrine release.	Norepinephrine	70-84	angiotensinogen	Homo sapiens	12-26
8384645-12	1993	During head-down tilt, plasma norepinephrine decreased with both angiotensin II and the vehicle control.	Norepinephrine	30-44	angiotensinogen	Homo sapiens	65-79
8402398-3	1993	Systemically, NPY has been demonstrated to act synergistically with norepinephrine.	Norepinephrine	68-82	neuropeptide Y	Rattus norvegicus	14-17
8402398-5	1993	The objectives of this study were to determine if NPY injected directly into the hypothalamus elicits cardiovascular responses and (or) if the simultaneous administration of NPY with norepinephrine alters the cardiovascular responses elicited by norepinephrine alone.	Norepinephrine	246-260	neuropeptide Y	Rattus norvegicus	174-177
8390529-1	1993	OBJECTIVE: The present study examines the effect of angiotensin converting enzyme inhibition on the renal haemodynamic and sodium excretory responses to noradrenaline in man.	Norepinephrine	153-166	angiotensin I converting enzyme	Homo sapiens	52-81
8387773-8	1993	Studies on cultured anterior pituitary cells suggested that adrenaline and noradrenaline may influence the secretion of ACTH, prolactin and TSH directly at the level of the pituitary.	Norepinephrine	75-88	proopiomelanocortin	Homo sapiens	120-124
8225541-0	1993	Magnesium and reserpine influence norepinephrine sensitivity of vas deferens in rats.	Norepinephrine	34-48	arginine vasopressin	Rattus norvegicus	64-67
8225541-1	1993	Reserpine induced supersensitivity to norepinephrine (NE) in rat vas deferens was sought by alteration of Mg++ and Ca++ concentration in incubation medium in the absence and presence of EDTA.	Norepinephrine	38-52	arginine vasopressin	Rattus norvegicus	65-68
8351952-2	1993	administration of corticotropin-releasing factor (CRF) antagonist, alpha-helical CRF9-41 (ahCRF) on stress-induced increases in noradrenaline (NA) release in rat brain regions.	Norepinephrine	128-141	corticotropin releasing hormone	Rattus norvegicus	18-48
8384247-0	1993	Regulation of beta 1-adrenergic receptor mRNA and ligand binding by antidepressant treatments and norepinephrine depletion in rat frontal cortex.	Norepinephrine	98-112	adrenoceptor beta 1	Rattus norvegicus	14-40
8384247-1	1993	The number of beta 1-adrenergic receptor (beta 1AR) binding sites is decreased by chronic antidepressant treatments, including electroconvulsive seizure (ECS) and imipramine, whereas administration of agents that deplete norepinephrine (NE) increases the number of beta 1AR binding sites in cerebral cortex.	Norepinephrine	221-235	adrenoceptor beta 1	Rattus norvegicus	42-50
8096672-4	1993	Because of differences in receptor population and agonist (i.e., norepinephrine) affinity, the beta 1-receptor is the predominate adrenergic subtype regulating contractility in the nonfailing myocardium.	Norepinephrine	65-79	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	95-101
8096672-8	1993	There is evidence that an increased cardiac norepinephrine concentration contributes to the decrease in beta 1-receptor density in heart failure.	Norepinephrine	44-58	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	104-110
8489125-2	1993	In patients with low renin essential hypertension, plasma and urinary norepinephrine levels, plasma renin activity and fractional excretion of sodium were significantly lower, while plasma volume, extracellular fluid volume and exchangeable sodium were higher than in normal renin essential hypertension.	Norepinephrine	70-84	renin	Homo sapiens	21-26
8449955-10	1993	Stimulations of astrocytes known to increase PKC activity, i.e. noradrenaline, or its inhibition by decreasing extracellular calcium concentrations, staurosporine, or desensitization following long term treatment with TPA, induced a phosphorylation or a dephosphorylation of PEA-15, respectively.	Norepinephrine	64-77	proline rich transmembrane protein 2	Homo sapiens	45-48
8474636-8	1993	These findings, which are similar to those observed previously with PVN injections of norepinephrine (NE), suggest that: (1) NPY receptors in the PVN, like alpha 2-noradrenergic receptors, are functional very early in the postnatal development of the rat; (2) NPY, in addition to its orexigenic effect, produces a small but significant dipsogenic effect; and (3) NPY may function cooperatively with NE in the PVN to stimulate feeding and drinking beginning at a very early age.	Norepinephrine	86-100	neuropeptide Y	Rattus norvegicus	125-128
8466711-5	1993	Chronic hPTH administration accelerated the development of hypertension and increased the pressor response to norepinephrine in rats fed a high calcium diet, but did not affect either parameter in rats fed a standard calcium diet.	Norepinephrine	110-124	parathyroid hormone	Homo sapiens	8-12
8402396-6	1993	A similar dose-dependent increase in norepinephrine output was also observed with ET-1.	Norepinephrine	37-51	endothelin 1	Canis lupus familiaris	82-86
8402396-7	1993	Following the initial peak observed during infusion with the highest dose of ET-1, the output of both epinephrine and norepinephrine remained significantly elevated over a period of 30 min.	Norepinephrine	118-132	endothelin 1	Canis lupus familiaris	77-81
7681496-1	1993	Development of desensitization to physiologic concentration of norepinephrine (NE 10(-9) M) and its effects on angiotensin II (AII) tachyphylaxis in the aortic rings of adult and aged normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were investigated.	Norepinephrine	63-77	angiotensinogen	Rattus norvegicus	111-125
7681496-1	1993	Development of desensitization to physiologic concentration of norepinephrine (NE 10(-9) M) and its effects on angiotensin II (AII) tachyphylaxis in the aortic rings of adult and aged normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were investigated.	Norepinephrine	63-77	angiotensinogen	Rattus norvegicus	127-130
7682512-6	1993	Furthermore, these inhibitors attenuated the norepinephrine-stimulated [Ca2+]i more strongly than contraction.	Norepinephrine	45-59	carbonic anhydrase 2	Rattus norvegicus	72-75
8384951-4	1993	Superoxide dismutase, either in the presence or absence of catalase, relaxed noradrenaline-induced tone.	Norepinephrine	77-90	catalase	Homo sapiens	59-67
8180414-2	1993	The synthesis of cyclic PIP is stimulated by insulin or noradrenaline (alpha-adrenergic action) in a dose-dependent fashion.	Norepinephrine	56-69	prolactin induced protein	Rattus norvegicus	24-27
8448583-9	1993	Noradrenaline infusion potentiated (up to 69%) endothelin-1-induced protein extravasation.	Norepinephrine	0-13	endothelin 1	Rattus norvegicus	47-59
8483806-1	1993	Neuropeptide Y (NPY) is a vasoconstrictor released with norepinephrine from perivascular sympathetic nerves.	Norepinephrine	56-70	neuropeptide Y	Rattus norvegicus	0-14
8483806-1	1993	Neuropeptide Y (NPY) is a vasoconstrictor released with norepinephrine from perivascular sympathetic nerves.	Norepinephrine	56-70	neuropeptide Y	Rattus norvegicus	16-19
8474537-0	1993	Effects of catechol-O-methyltransferase inhibition on the plasma clearance of noradrenaline and the formation of 3,4-dihydroxyphenylglycol in the rabbit.	Norepinephrine	78-91	catechol O-methyltransferase	Oryctolagus cuniculus	11-39
8095104-11	1993	In view of the vasoconstrictive properties of both NPY and noradrenaline, it may be assumed that the abundance of NPY- and TH-immunoreactive nerves fibers in blood vessel walls reflects a vasoregulatory activity.	Norepinephrine	59-72	neuropeptide Y	Rattus norvegicus	114-117
8440783-8	1993	The differential distribution of dopamine-beta-hydroxylase-immunoreactive processes may reflect a potential role of norepinephrine as a regulator of a variety of functions associated with the nuclei that are most heavily innervated, e.g., neuroendocrine release from the paraventricular and supraoptic nuclei, and gonadotropin release from the medial preoptic area and mediobasal hypothalamus.	Norepinephrine	116-130	dopamine beta-hydroxylase	Macaca mulatta	33-58
7687835-11	1993	As it was insufficient, an infusion of up to 1 microgram.kg-1 x min-1 noradrenaline was required.	Norepinephrine	70-83	CD59 molecule (CD59 blood group)	Homo sapiens	64-69
8430802-0	1993	Interleukin-1 beta modulation of norepinephrine release from rat myenteric nerves.	Norepinephrine	33-47	interleukin 1 beta	Rattus norvegicus	0-18
8431775-0	1993	Corticotropin-releasing factor enhances noradrenaline release in the rat hypothalamus assessed by intracerebral microdialysis.	Norepinephrine	40-53	corticotropin releasing hormone	Rattus norvegicus	0-30
8384045-3	1993	In this study, we have determined whether ICV administration of IL-1 beta has an effect on sympathetic outflow and norepinephrine (NE) turnover in the spleen.	Norepinephrine	115-129	interleukin 1 beta	Rattus norvegicus	64-73
7520295-9	1993	beta-endorphin, which may be the "missing link" between the neuron and the wall of the arteriole, must be considered as being a fundamental neurotransmitter in the same way as well-known substances such as noradrenaline, acetylcholine, serotonin, dopamine and the GABAergic system are also neurotransmitters.	Norepinephrine	206-219	proopiomelanocortin	Homo sapiens	0-14
8244191-6	1993	The response of ET-1 was more powerful than the effect of the reference compounds, i.e. noradrenaline with regard to myometrial arteries and oxytocin with regard to the myometrium.	Norepinephrine	88-101	endothelin 1	Homo sapiens	16-20
8403943-8	1993	Angiotensin converting enzyme (ACE) inhibitors are unique in not only decreasing ventricular afterload and improving haemodynamics but, also, in decreasing circulating norepinephrine levels, protecting kidneys from inappropriate efferent arteriolo-constriction and suppression of aldosterone secretion.	Norepinephrine	168-182	angiotensin I converting enzyme	Homo sapiens	0-29
8403943-8	1993	Angiotensin converting enzyme (ACE) inhibitors are unique in not only decreasing ventricular afterload and improving haemodynamics but, also, in decreasing circulating norepinephrine levels, protecting kidneys from inappropriate efferent arteriolo-constriction and suppression of aldosterone secretion.	Norepinephrine	168-182	angiotensin I converting enzyme	Homo sapiens	31-34
8370569-6	1993	The maximal contraction to a single concentration of angiotensin II (0.1 microM) in the rings without endothelium amounted to 75.8 +/- 3.8% of the preceding response to a supramaximal concentration of noradrenaline (= Emax).	Norepinephrine	201-214	angiotensinogen	Rattus norvegicus	53-67
8384045-0	1993	Central administration of interleukin-1 beta increases norepinephrine turnover in the spleen.	Norepinephrine	55-69	interleukin 1 beta	Rattus norvegicus	26-44
8093234-1	1993	Ciliary neurotrophic factor (CNTF) was found to promote the expression of tyrosine hydroxylase (TH) immunoreactivity by cultured noradrenergic neurons from the locus coeruleus (LC) of E18 rat fetuses, but only in the concomitant presence of norepinephrine (NE), their own neurotransmitter.	Norepinephrine	241-255	ciliary neurotrophic factor	Rattus norvegicus	0-27
8093234-1	1993	Ciliary neurotrophic factor (CNTF) was found to promote the expression of tyrosine hydroxylase (TH) immunoreactivity by cultured noradrenergic neurons from the locus coeruleus (LC) of E18 rat fetuses, but only in the concomitant presence of norepinephrine (NE), their own neurotransmitter.	Norepinephrine	241-255	ciliary neurotrophic factor	Rattus norvegicus	29-33
8380384-7	1993	Moreover, prazosin, a selective alpha 1-adrenergic receptor blocker, prevented pineal NAT activation by norepinephrine or darkness at night in 2-week-old rats, but not in adult animals.	Norepinephrine	104-118	N-acetyltransferase 1	Rattus norvegicus	86-89
8482494-0	1993	Effect of testosterone on the response of young rat vas deferens to norepinephrine.	Norepinephrine	68-82	arginine vasopressin	Rattus norvegicus	52-55
8417009-1	1993	DOPA decarboxylase is the enzyme directly responsible for the synthesis of the neurotransmitters dopamine and serotonin, and indirectly of noradrenaline, in brain.	Norepinephrine	139-152	dopa decarboxylase	Homo sapiens	0-18
15278500-6	1993	Similarly, total norepinephrine and epinephrine also increased at the end of PCB, while total dopamine did not change.	Norepinephrine	17-31	pyruvate carboxylase	Homo sapiens	77-80
8505861-1	1993	The purpose of this study was to investigate the effects of circulating interleukin-1 beta (IL-1 beta) on the release of norepinephrine (NE) in the paraventricular nucleus (PVN).	Norepinephrine	121-135	interleukin 1 beta	Rattus norvegicus	72-90
8391619-2	1993	To explore whether there is a rapid change in the secretory response of the hypothalamic CRH neuron during acute stress, we report here a study of the effects of KCl and norepinephrine (NE) on CRH release in vitro from rat hypothalami explanted after 5, 30, 60, and 120 minutes of immobilization.	Norepinephrine	170-184	corticotropin releasing hormone	Rattus norvegicus	193-196
8505861-1	1993	The purpose of this study was to investigate the effects of circulating interleukin-1 beta (IL-1 beta) on the release of norepinephrine (NE) in the paraventricular nucleus (PVN).	Norepinephrine	121-135	interleukin 1 beta	Rattus norvegicus	92-101
8446180-5	1993	Intravenous infusion of noradrenaline (5 micrograms.kg-1.min-1) elicited a pronounced pressor response which was also associated with a decrease in the release of noradrenaline in the locus coeruleus.	Norepinephrine	24-37	CD59 molecule (CD59 blood group)	Homo sapiens	57-62
7509962-4	1993	Vasoconstrictor responses induced by norepinephrine (30-300 pmol) increased with time in control experiments, but the increase was markedly greater in the presence of 10 and 100 pM ET-1.	Norepinephrine	37-51	endothelin 1	Rattus norvegicus	181-185
8446180-5	1993	Intravenous infusion of noradrenaline (5 micrograms.kg-1.min-1) elicited a pronounced pressor response which was also associated with a decrease in the release of noradrenaline in the locus coeruleus.	Norepinephrine	163-176	CD59 molecule (CD59 blood group)	Homo sapiens	57-62
8429922-7	1993	In the presence of TTX and guanethidine ET-1 potentiated the contractile effects of low (0.01-1 microM) concentrations of noradrenaline (NA) and did not change the contractions induced by NA at concentrations higher than 3 microM.	Norepinephrine	122-135	endothelin 1	Rattus norvegicus	40-44
1481943-6	1992	Compared with control (placebo), ANP produced a hemoconcentration and increased plasma norepinephrine, but did not change heart rate, blood pressure, plasma levels of renin, aldosterone, or vasopressin, or renal excretion of volume or sodium.	Norepinephrine	87-101	natriuretic peptide A	Homo sapiens	33-36
7509962-7	1993	The responses to norepinephrine (3-100 pmol) were also enhanced by 1 pM ET-1 in the presence of NOLA.	Norepinephrine	17-31	endothelin 1	Rattus norvegicus	72-76
1473014-4	1992	Administration of IRAP largely prevented the effects of IL-1 alpha or IL-1 beta on the elevation of plasma corticosterone and the concomitant increase in hypothalamic norepinephrine metabolism, but failed to alter the responses to LPS.	Norepinephrine	167-181	interleukin 1 beta	Mus musculus	70-79
1490588-2	1992	ANP inhibited contraction produced by human angiotensin II (AT II), norepinephrine (NE), and arginine vasopressin (AVP) in isolated toad aortic rings.	Norepinephrine	68-82	natriuretic peptide A	Homo sapiens	0-3
1359017-2	1992	NPY inhibited the intracellular cAMP accumulation stimulated by isoproterenol and norepinephrine in a dose-dependent manner during a 10-min incubation of pinealocytes.	Norepinephrine	82-96	neuropeptide Y	Rattus norvegicus	0-3
1280596-6	1992	This dose of vasopressin also augmented pressor responses to noradrenaline and sympathetic nerve stimulation similarly in both control and endotoxin-treated rats.	Norepinephrine	61-74	arginine vasopressin	Rattus norvegicus	13-24
1337912-7	1992	Locally generated angiotensin II increased sympathetic vasoconstriction through the presynaptic release of noradrenaline and this effect was mediated by beta-adrenoceptor stimulation.	Norepinephrine	107-120	angiotensinogen	Homo sapiens	18-32
1478241-7	1992	Inhibition by insulin of noradrenaline-stimulated lipolysis in isolated adipocytes was more severely impaired in oIGT than in oNGT compared with the controls (P < 0.001).	Norepinephrine	25-38	insulin	Homo sapiens	14-21
1338944-1	1992	Among the agonists examined, the rank order of efficacies in causing phosphoinositide hydrolysis was bradykinin > endothelin-1 > ATP > norepinephrine.	Norepinephrine	144-158	endothelin 1	Rattus norvegicus	117-129
1336886-12	1992	Nor-adrenaline supplementation may be necessary after prolonged CPR.	Norepinephrine	0-14	cytochrome p450 oxidoreductase	Homo sapiens	64-67
1398888-6	1992	Norepinephrine, angiotensin II, and endothelin-1 increased renal vascular resistance in salt-sensitive rats by 126%, 135%, and 135%, respectively (p less than 0.01); norepinephrine and angiotensin II did not change renal vascular resistance of salt-resistant rats, but endothelin-1 decreased renal vascular resistance in salt-resistant rats by 30% (p less than 0.01).	Norepinephrine	0-14	angiotensinogen	Rattus norvegicus	185-199
1429846-6	1992	When the isomers of inositol monophosphate, Ins 1P and Ins 4P, were separated by HPLC, it was shown that after prelabeled tail artery was stimulated by norepinephrine for periods of 1-2 min, the predominant isomer formed was Ins 4P, indicating either PIP2 or PIP as the source.	Norepinephrine	152-166	prolactin induced protein	Rattus norvegicus	251-254
1445298-5	1992	In the presence of norepinephrine (NE) the beta-MyHC gene is remarkably induced (within 24 hours following the addition of norepinephrine to the cardiocyte culture).	Norepinephrine	19-33	myosin heavy chain 6	Homo sapiens	48-52
1445298-5	1992	In the presence of norepinephrine (NE) the beta-MyHC gene is remarkably induced (within 24 hours following the addition of norepinephrine to the cardiocyte culture).	Norepinephrine	123-137	myosin heavy chain 6	Homo sapiens	48-52
1360185-2	1992	We studied the influence of the long-acting somatostatin analogue octreotide on norepinephrine (NE)-induced changes in intracellular calcium ([Ca2+]i) in fura-2 loaded single cells of a rat medullary carcinoma cell line, rMTC 6-23.	Norepinephrine	80-94	somatostatin	Rattus norvegicus	44-56
1474060-11	1992	During the same exercise condition leg norepinephrine spillover increased from a control value of 2.64 +/- 1.16 to 5.62 +/- 2.13 nM/min with beta 1-blockade (P < 0.05).	Norepinephrine	39-53	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	141-147
1460089-0	1992	Presynaptic inhibitory effect of TNF-alpha on the release of noradrenaline in isolated median eminence.	Norepinephrine	61-74	tumor necrosis factor	Rattus norvegicus	33-42
1460089-1	1992	The effect of tumor necrosis factor-alpha (TNF-alpha) on the stimulation-evoked release of noradrenaline (NA) from isolated rat median eminence (ME) was investigated, using a low-volume perfusion system.	Norepinephrine	91-104	tumor necrosis factor	Rattus norvegicus	14-41
1460089-1	1992	The effect of tumor necrosis factor-alpha (TNF-alpha) on the stimulation-evoked release of noradrenaline (NA) from isolated rat median eminence (ME) was investigated, using a low-volume perfusion system.	Norepinephrine	91-104	tumor necrosis factor	Rattus norvegicus	43-52
1461360-0	1992	Norepinephrine, dopamine, and 5-HT release from perfused hypothalamus of the rat during feeding induced by neuropeptide Y.	Norepinephrine	0-14	neuropeptide Y	Rattus norvegicus	107-121
1465217-7	1992	These findings clearly identify nAChRs in SH-SY5Y cells, and provide two possible mechanisms by which receptor activation may lead to noradrenaline release, namely by triggering Ca2+ influx through the nAChR itself or by opening voltage-gated Ca2+ channels.	Norepinephrine	134-147	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	32-37
1398888-6	1992	Norepinephrine, angiotensin II, and endothelin-1 increased renal vascular resistance in salt-sensitive rats by 126%, 135%, and 135%, respectively (p less than 0.01); norepinephrine and angiotensin II did not change renal vascular resistance of salt-resistant rats, but endothelin-1 decreased renal vascular resistance in salt-resistant rats by 30% (p less than 0.01).	Norepinephrine	0-14	endothelin 1	Rattus norvegicus	269-281
1398888-6	1992	Norepinephrine, angiotensin II, and endothelin-1 increased renal vascular resistance in salt-sensitive rats by 126%, 135%, and 135%, respectively (p less than 0.01); norepinephrine and angiotensin II did not change renal vascular resistance of salt-resistant rats, but endothelin-1 decreased renal vascular resistance in salt-resistant rats by 30% (p less than 0.01).	Norepinephrine	166-180	angiotensinogen	Rattus norvegicus	16-30
1398888-6	1992	Norepinephrine, angiotensin II, and endothelin-1 increased renal vascular resistance in salt-sensitive rats by 126%, 135%, and 135%, respectively (p less than 0.01); norepinephrine and angiotensin II did not change renal vascular resistance of salt-resistant rats, but endothelin-1 decreased renal vascular resistance in salt-resistant rats by 30% (p less than 0.01).	Norepinephrine	166-180	endothelin 1	Rattus norvegicus	36-48
1328518-1	1992	In this study, the in vitro effects of ethanol on norepinephrine-stimulated cyclic AMP (cAMP), N-acetyltransferase (NAT), and melatonin (MT) production were examined in dispersed rat pinealocytes.	Norepinephrine	50-64	N-acetyltransferase 1	Rattus norvegicus	116-119
1328518-3	1992	It was found that ethanol less than or equal to 200 mM had no effect on norepinephrine-stimulated cAMP response, whereas 25 mM ethanol resulted in a significant inhibition of norepinephrine-stimulated NAT and MT levels.	Norepinephrine	175-189	N-acetyltransferase 1	Rattus norvegicus	201-204
1338095-17	1992	Caffeine inhibited the increased [Ca2+]i and developed tension during stimulation by 10(-5) M-noradrenaline, in a concentration-dependent manner.	Norepinephrine	94-107	carbonic anhydrase 2	Rattus norvegicus	34-37
1338095-20	1992	Inhibition of an increase in [Ca2+]i in relation to the inhibition of tension during noradrenaline stimulation was much greater than that in 118 mM-K+ depolarization.	Norepinephrine	85-98	carbonic anhydrase 2	Rattus norvegicus	30-33
1436133-5	1992	Pressure ejection of noradrenaline produced hyperpolarization which was potentiated in the presence of NPY (0.1 mumol/l).	Norepinephrine	21-34	neuropeptide Y	Rattus norvegicus	103-106
1426028-0	1992	Norepinephrine-induced Ca2+ current inhibition in adult rat sympathetic neurons does not require protein kinase C activation.	Norepinephrine	0-14	carbonic anhydrase 2	Rattus norvegicus	23-26
1426028-1	1992	Experiments were performed to investigate if protein kinase C is involved in the norepinephrine-induced alpha 2-adrenoceptor-mediated inhibition of the Ca2+ current in adult rat superior cervical ganglion neurons.	Norepinephrine	81-95	carbonic anhydrase 2	Rattus norvegicus	152-155
1426028-3	1992	Both norepinephrine and the protein kinase C activator, 1,2-dioctanoylglycerol (diC8) decreased the Ca2+ current induced by step depolarizations to +10 mV from a holding potential of -80 mV.	Norepinephrine	5-19	carbonic anhydrase 2	Rattus norvegicus	100-103
1426028-4	1992	In the presence of norepinephrine, the Ca2+ current rising phase was adequately fit by a double exponential with a second time constant much larger than control, whereas in the presence of diC8 the rising phase became mono-exponential and the current displayed a prominent decay.	Norepinephrine	19-33	carbonic anhydrase 2	Rattus norvegicus	39-42
1436133-6	1992	Hence, NPY appears to inhibit the release of noradrenaline from dendrites or recurrent axon collaterals of LC neurones.	Norepinephrine	45-58	neuropeptide Y	Rattus norvegicus	7-10
1325838-0	1992	Characterization of ATP receptor which mediates norepinephrine release in PC12 cells.	Norepinephrine	48-62	purinergic receptor P2X 7	Rattus norvegicus	20-32
1325838-10	1992	We suggest that the 53-kDa protein on the PC12 cell surface is an ATP receptor, which mediates the norepinephrine release, depending, mainly, on extracellular Ca2+ gating.	Norepinephrine	99-113	purinergic receptor P2X 7	Rattus norvegicus	66-78
1418846-7	1992	Plasma renin activity was positively correlated to plasma norepinephrine in the hypertensive women only (r = 0.41, P less than .05).	Norepinephrine	58-72	renin	Homo sapiens	7-12
1455014-2	1992	Preincubation with vasostatin (0.8 micrograms/ml), containing the N-terminal domain of CGA, (CGA1-76, CGA1-113 and CGA1-143ff), inhibited the contractile responses evoked by 80 mM K+, 2.6 microM noradrenaline (NA), or 65 nM endothelin-1 (ET-1) in Ca(2+)-free solution in SV but not in ITA.	Norepinephrine	195-208	chromogranin A	Homo sapiens	87-90
1329525-3	1992	Addition of 5-(N,N-hexamethylene)amiloride, a potent inhibitor of the Na(+)-H+ antiport, dose dependently inhibited norepinephrine- and isoproterenol-stimulated N-acetyltransferase (NAT) activity and melatonin production.	Norepinephrine	116-130	N-acetyltransferase 1	Rattus norvegicus	161-180
1329525-3	1992	Addition of 5-(N,N-hexamethylene)amiloride, a potent inhibitor of the Na(+)-H+ antiport, dose dependently inhibited norepinephrine- and isoproterenol-stimulated N-acetyltransferase (NAT) activity and melatonin production.	Norepinephrine	116-130	N-acetyltransferase 1	Rattus norvegicus	182-185
1397783-10	1992	Both insulin clamps induced minor, but significant, increases in forearm venous plasma noradrenaline concentrations.	Norepinephrine	87-100	insulin	Homo sapiens	5-12
1330166-7	1992	NPY (0.1-0.3 microM) enhanced only the contractile responses to low doses of noradrenaline (NA, 0.003-0.01 microM).	Norepinephrine	77-90	neuropeptide Y	Rattus norvegicus	0-3
1458970-2	1992	In organ chamber experiments, both acetylcholine and bradykinin induced an endothelium-dependent relaxation of norepinephrine-contracted canine femoral arteries in a concentration-dependent manner; the relaxation induced by acetylcholine, but not that by bradykinin, was inhibited by anisodamine or atropine in a concentration-dependent manner.	Norepinephrine	111-125	kininogen 1	Canis lupus familiaris	53-63
1280233-4	1992	Norepinephrine (NE), an alpha-adrenergic agonist, had no effect on basal PRL secretion but abolished thyrotropin-releasing hormone (TRH)-induced PRL secretion in a dose-dependent manner (EC50 100 nM).	Norepinephrine	0-14	prolactin	Rattus norvegicus	145-148
1458970-2	1992	In organ chamber experiments, both acetylcholine and bradykinin induced an endothelium-dependent relaxation of norepinephrine-contracted canine femoral arteries in a concentration-dependent manner; the relaxation induced by acetylcholine, but not that by bradykinin, was inhibited by anisodamine or atropine in a concentration-dependent manner.	Norepinephrine	111-125	kininogen 1	Canis lupus familiaris	255-265
1320047-2	1992	The lipolytic sensitivity of the nonselective beta-agonists epinephrine and isoprenaline as well as the selective agonists norepinephrine (beta 1) and terbutaline (beta 2) was significantly increased 5-10 times in omental fat cells.	Norepinephrine	123-137	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	139-145
1325509-4	1992	Plasma NPY-li levels were also correlated with norepinephrine levels only in hypertensive rats, but were correlated with epinephrine levels only in normotensive animals.	Norepinephrine	47-61	neuropeptide Y	Rattus norvegicus	7-10
1325509-6	1992	CONCLUSIONS: In DOCA-salt hypertensive rats, increased plasma NPY-li levels originate primarily from the sympathetic nerves, since those levels were correlated exclusively with circulating norepinephrine levels and they were associated with a reduction in NPY-li content of the heart and mesenteric artery.	Norepinephrine	189-203	neuropeptide Y	Rattus norvegicus	62-65
1497634-2	1992	Addition of calmodulin to the permeabilized cells increased Ca(2+)-dependent norepinephrine release in a dose-dependent manner.	Norepinephrine	77-91	calmodulin	Bos taurus	12-22
1497634-5	1992	Th release of norepinephrine enhanced by calmodulin was inhibited by tetanus toxin, which specifically inhibits exocytotic secretion.	Norepinephrine	14-28	calmodulin	Bos taurus	41-51
1639176-9	1992	The norepinephrine content of the vas deferens of rats pretreated with 6-OHDA was markedly reduced (p less than 0.001) after administration of AMT, whereas that of the vehicle-treated rats remained unchanged.	Norepinephrine	4-18	arginine vasopressin	Rattus norvegicus	34-37
1433167-0	1992	ACE inhibition in diabetic patients: effect on pressor responsiveness to noradrenaline.	Norepinephrine	73-86	angiotensin I converting enzyme	Homo sapiens	0-3
1473654-2	1992	Ace inhibitors give clinical and hemodynamic benefits and lower plasma angiotensin and norepinephrine levels.	Norepinephrine	87-101	angiotensin I converting enzyme	Homo sapiens	0-3
1317354-7	1992	In contrast, norepinephrine-stimulated 45Ca2+ efflux in the absence of extracellular Ca2+ was significantly greater in arteries from DOCA rats than in those from sham rats.	Norepinephrine	13-27	carbonic anhydrase 2	Rattus norvegicus	41-44
1511517-9	1992	The segregation of noradrenaline immunoreactivity in the ventral and dorsal horns, the IML and the periependymal area was more obvious at all levels by P14 and P20.	Norepinephrine	19-32	heat shock protein family B (small) member 6	Rattus norvegicus	160-163
1352549-7	1992	For ICYP/agonist competition binding experiments the relative ability to displace ICYP was isoproterenol greater than epinephrine = norepinephrine, a profile typical of beta-1 adrenergic receptors.	Norepinephrine	132-146	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	169-175
1524760-8	1992	Likewise the increase in plasma norepinephrine was blunted on insulin and captopril.	Norepinephrine	32-46	insulin	Homo sapiens	62-69
1524760-9	1992	Thus, when the generation of angiotensin II was blocked by captopril the insulin-induced rise in epinephrine and norepinephrine was blunted.	Norepinephrine	113-127	angiotensinogen	Homo sapiens	29-43
1524760-9	1992	Thus, when the generation of angiotensin II was blocked by captopril the insulin-induced rise in epinephrine and norepinephrine was blunted.	Norepinephrine	113-127	insulin	Homo sapiens	73-80
1317354-9	1992	We conclude that increased vascular sensitivity to norepinephrine in mineralocorticoid hypertension is related to increased release of Ca2+ from a subcellular store and not to changes in agonist affinity or to the contractile protein interaction.	Norepinephrine	51-65	carbonic anhydrase 2	Rattus norvegicus	135-138
1578367-1	1992	In isolated rat aorta, 72.7 mM KCI, 10 microM prostaglandin F2 alpha, 30 nM endothelin-1 and 1 microM norepinephrine increased muscle tension, cytosolic Ca++ concentration ([Ca++]i) and 20 kDa myosin light chain (MLC) phosphorylation.	Norepinephrine	102-116	endothelin 1	Rattus norvegicus	76-94
1423026-0	1992	Monophasic and biphasic effects of angiotensin II and III on norepinephrine uptake and release in rat adrenal medulla.	Norepinephrine	61-75	angiotensinogen	Rattus norvegicus	35-57
1423026-3	1992	In this work, angiotensin II and III effects on norepinephrine uptake and release in rat adrenal medulla were investigated.	Norepinephrine	48-62	angiotensinogen	Rattus norvegicus	14-28
1423026-5	1992	Angiotensin II showed a biphasic effect only on evoked neuronal norepinephrine release (an earlier decrease followed by a later increase), while increasing the spontaneous norepinephrine release only after 12 min.	Norepinephrine	64-78	angiotensinogen	Rattus norvegicus	0-14
1423026-5	1992	Angiotensin II showed a biphasic effect only on evoked neuronal norepinephrine release (an earlier decrease followed by a later increase), while increasing the spontaneous norepinephrine release only after 12 min.	Norepinephrine	172-186	angiotensinogen	Rattus norvegicus	0-14
1351098-1	1992	Earlier investigation of the vascular actions of Neuropeptide Y (NPY) led us to propose that distinct receptors mediated the prejunctional inhibition of periarterial nerve-stimulated norepinephrine (NE) release and the postjunctional potentiation of the increase in perfusion pressure elicited by vasoconstrictors.	Norepinephrine	183-197	neuropeptide Y	Rattus norvegicus	49-63
1351098-1	1992	Earlier investigation of the vascular actions of Neuropeptide Y (NPY) led us to propose that distinct receptors mediated the prejunctional inhibition of periarterial nerve-stimulated norepinephrine (NE) release and the postjunctional potentiation of the increase in perfusion pressure elicited by vasoconstrictors.	Norepinephrine	183-197	neuropeptide Y	Rattus norvegicus	65-68
1592464-9	1992	These results suggest that endogenous Ang II facilitates the release of norepinephrine from sympathetic nerve terminals in the vasculature of pithed rats.	Norepinephrine	72-86	angiotensinogen	Rattus norvegicus	38-44
1525014-8	1992	Injections of noradrenaline and exposure of BAT-tumor-bearing rats to cold stress increased both the amount of UCP and the expression of UCP mRNA in tumors of BAT; i.e., experimentally developed BAT entirely resembled standard BAT.	Norepinephrine	14-27	uncoupling protein 1	Rattus norvegicus	111-114
1525014-8	1992	Injections of noradrenaline and exposure of BAT-tumor-bearing rats to cold stress increased both the amount of UCP and the expression of UCP mRNA in tumors of BAT; i.e., experimentally developed BAT entirely resembled standard BAT.	Norepinephrine	14-27	uncoupling protein 1	Rattus norvegicus	137-140
1593712-0	1992	Phospholipase C activation by endothelin-1 and noradrenaline in isolated penile erectile tissue from rabbit.	Norepinephrine	47-60	LOC100009319	Oryctolagus cuniculus	0-15
1593712-1	1992	The effects of endothelin-1 and noradrenaline on phospholipase C activity in the rabbit isolated corpus cavernosum were investigated by measuring the accumulation of inositol phosphates.	Norepinephrine	32-45	LOC100009319	Oryctolagus cuniculus	49-64
1593712-9	1992	The results suggest that exogenous endothelin-1 and noradrenaline activate phospholipase C in corpus cavernosum, and that this mechanism is partly independent of extracellular Ca2+.	Norepinephrine	52-65	LOC100009319	Oryctolagus cuniculus	75-90
1320721-1	1992	Phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28) catalyzes the conversion of norepinephrine to epinephrine, the last step of catecholamine biosynthesis.	Norepinephrine	87-101	phenylethanolamine-N-methyltransferase	Mus musculus	0-38
1320721-1	1992	Phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28) catalyzes the conversion of norepinephrine to epinephrine, the last step of catecholamine biosynthesis.	Norepinephrine	87-101	phenylethanolamine-N-methyltransferase	Mus musculus	40-44
1324065-6	1992	When aortic rings were contracted with noradrenaline (NA) to 1 g of tension, ET-1 caused further contraction of these rings.	Norepinephrine	39-52	endothelin 1	Rattus norvegicus	77-81
1377730-7	1992	Norepinephrine (10(-6) M) inhibited the release of SP and NKA (to 69 +/- 6% and 80 +/- 6% of basal release, n = 7).	Norepinephrine	0-14	tachykinin precursor 1	Homo sapiens	51-61
1381781-7	1992	Exposure to IL-1 beta depressed the response to noradrenaline (NA) in several hours in rabbit aorta rings.	Norepinephrine	48-61	interleukin-1 beta	Oryctolagus cuniculus	12-21
1607879-11	1992	These results demonstrated that dopamine-beta-hydroxylase and norepinephrine-immunopositive, as well as chromaffin cells, were identical to the cells which take up exogenous norepinephrine, described in part I of this study.	Norepinephrine	174-188	dopamine beta-hydroxylase	Oryctolagus cuniculus	32-57
1314337-2	1992	The potential confound of baroreceptor inhibition of AVP release by the pressor effect of methoxamine was addressed by measuring the plasma AVP response to infusion of norepinephrine (NE), an alpha 1 agonist which does not enter the CNS and which produced an equivalent pressor effect.	Norepinephrine	168-182	arginine vasopressin	Homo sapiens	140-143
1604044-2	1992	Some anesthetic agents are known to modify plasma levels of catecholamines; moreover NPY is co-released with noradrenaline or adrenaline under certain conditions.	Norepinephrine	109-122	neuropeptide Y	Rattus norvegicus	85-88
1579658-0	1992	Norepinephrine amplifies effects of vasopressin on the isolated rat heart.	Norepinephrine	0-14	arginine vasopressin	Rattus norvegicus	36-47
1614821-3	1992	The neurotransmitters acetylcholine (ACh) and noradrenaline inhibited ICa.	Norepinephrine	46-59	inhibitor of carbonic anhydrase	Mus musculus	70-73
1559192-1	1992	HYPOTHESIS: Impaired baroreflex-induced release of noradrenaline during angiotensin converting enzyme (ACE) inhibition may interfere with orthostatic responses of blood pressure.	Norepinephrine	51-64	angiotensin I converting enzyme	Homo sapiens	103-106
1320981-5	1992	The concentration-response curve of the vas to exogenously-applied noradrenaline (NA) was unaffected by CEC (10(-6) M) but was flattened by nifedipine (10(-5) M).	Norepinephrine	67-80	arginine vasopressin	Rattus norvegicus	40-43
1350498-0	1992	Norepinephrine increases angiotensin II binding in rat brain synaptosomes.	Norepinephrine	0-14	angiotensinogen	Rattus norvegicus	25-39
1537296-0	1992	Norepinephrine release in the immature ovary is regulated by autoreceptors and neuropeptide-Y.	Norepinephrine	0-14	neuropeptide Y	Rattus norvegicus	79-93
1322336-5	1992	3. beta-Adrenoceptor blocker propranolol and histamine H2-receptor blocker cimetidine inhibited the effects of noradrenaline and histamine respectively without altering the positive chronotropic effect of 15-Me-PGE1.	Norepinephrine	111-124	histamine H2 receptor	Cavia porcellus	45-66
1537296-1	1992	Experiments were undertaken to study the role that neuropeptide-Y (NPY) and adrenergic autoreceptors may play in the regulation of norepinephrine (NE) release from the rat ovary.	Norepinephrine	131-145	neuropeptide Y	Rattus norvegicus	51-65
1537296-1	1992	Experiments were undertaken to study the role that neuropeptide-Y (NPY) and adrenergic autoreceptors may play in the regulation of norepinephrine (NE) release from the rat ovary.	Norepinephrine	131-145	neuropeptide Y	Rattus norvegicus	67-70
1542654-5	1992	These results indicate that the additional PNMT expression in norepinephrine-producing cells can convert these cells to the epinephrine phenotype, and suggest that norepinephrine-producing cells normally possess the basic machinery required for the synthesis of epinephrine except for PNMT.	Norepinephrine	164-178	phenylethanolamine-N-methyltransferase	Mus musculus	43-47
1542654-1	1992	Epinephrine-producing cells are characterized by the presence of phenylethanolamine N-methyltransferase (PNMT), which catalyzes the formation of epinephrine from norepinephrine.	Norepinephrine	162-176	phenylethanolamine-N-methyltransferase	Mus musculus	65-103
1542654-1	1992	Epinephrine-producing cells are characterized by the presence of phenylethanolamine N-methyltransferase (PNMT), which catalyzes the formation of epinephrine from norepinephrine.	Norepinephrine	162-176	phenylethanolamine-N-methyltransferase	Mus musculus	105-109
1542654-5	1992	These results indicate that the additional PNMT expression in norepinephrine-producing cells can convert these cells to the epinephrine phenotype, and suggest that norepinephrine-producing cells normally possess the basic machinery required for the synthesis of epinephrine except for PNMT.	Norepinephrine	62-76	phenylethanolamine-N-methyltransferase	Mus musculus	43-47
1542654-5	1992	These results indicate that the additional PNMT expression in norepinephrine-producing cells can convert these cells to the epinephrine phenotype, and suggest that norepinephrine-producing cells normally possess the basic machinery required for the synthesis of epinephrine except for PNMT.	Norepinephrine	62-76	phenylethanolamine-N-methyltransferase	Mus musculus	285-289
1534369-2	1992	We tested the hypotheses that coupling between oxidative metabolism and force in noradrenaline (NOR)-activated rabbit aorta is controlled (a) by an energy-dependent step or steps in receptor-operated coupling mechanisms upstream to myosin light chain (MLC) kinase, or (b) by energy limitation of MLC kinase-mediated phosphorylation of the MLC or actin-activated myosin ATPase.	Norepinephrine	81-94	myosin light chain kinase, smooth muscle	Oryctolagus cuniculus	232-263
1534369-2	1992	We tested the hypotheses that coupling between oxidative metabolism and force in noradrenaline (NOR)-activated rabbit aorta is controlled (a) by an energy-dependent step or steps in receptor-operated coupling mechanisms upstream to myosin light chain (MLC) kinase, or (b) by energy limitation of MLC kinase-mediated phosphorylation of the MLC or actin-activated myosin ATPase.	Norepinephrine	81-94	myosin light chain kinase, smooth muscle	Oryctolagus cuniculus	296-306
1628451-2	1992	In control subjects, insulin-induced hypoglycemia resulted in marked increases in plasma epinephrine and norepinephrine levels.	Norepinephrine	105-119	insulin	Homo sapiens	21-28
1542835-1	1992	Correlation between increased cranial and peripheral norepinephrines and increased cranial to systemic renin ratio has been observed in a small number of patients with postcarotid endarterectomy hypertension.	Norepinephrine	53-68	renin	Homo sapiens	103-108
1542654-5	1992	These results indicate that the additional PNMT expression in norepinephrine-producing cells can convert these cells to the epinephrine phenotype, and suggest that norepinephrine-producing cells normally possess the basic machinery required for the synthesis of epinephrine except for PNMT.	Norepinephrine	164-178	phenylethanolamine-N-methyltransferase	Mus musculus	285-289
1542654-6	1992	Thus it appears that the only major difference between norepinephrine- and epinephrine-producing cells is the expression of PNMT.	Norepinephrine	55-69	phenylethanolamine-N-methyltransferase	Mus musculus	124-128
1737646-2	1992	The effects of angiotensin II and endothelin-1 on vascular sensitivity to norepinephrine were studied in perfused rat mesenteric resistance arteries.	Norepinephrine	74-88	endothelin 1	Rattus norvegicus	34-46
1312014-4	1992	A 24 h pre-incubation with either CRH, epinephrine or nor-epinephrine increased the [125I]IL-1 alpha binding sites in the AtT-20 cells and conversely, a similar pre-incubation with either dexamethasone or tumour necrosis factor-alpha (TNF alpha) decreased them without affecting the affinity of the receptors in either case.	Norepinephrine	54-69	tumor necrosis factor	Mus musculus	235-244
1735563-0	1992	Insulin enhances pressor responses to norepinephrine in rat mesenteric vasculature.	Norepinephrine	38-52	insulin	Homo sapiens	0-7
1735563-4	1992	However, insulin significantly increased the pressor responses to norepinephrine.	Norepinephrine	66-80	insulin	Homo sapiens	9-16
1735563-7	1992	The mechanism or mechanisms for the augmented pressor response to norepinephrine after insulin infusion remain to be determined.	Norepinephrine	66-80	insulin	Homo sapiens	87-94
1737646-4	1992	Perfusion (5 hours) of the arteries with angiotensin II (10(-7) M) potentiated contractions in arteries with endothelium induced by norepinephrine in spontaneously hypertensive rats but not Wistar-Kyoto rats.	Norepinephrine	132-146	angiotensinogen	Rattus norvegicus	41-55
1310483-5	1992	The facilitatory effect of angiotensin II on both nerve stimulation and exogenous norepinephrine was blocked by saralasin.	Norepinephrine	82-96	angiotensinogen	Rattus norvegicus	27-41
1737646-9	1992	Threshold concentrations of exogenous endothelin-1 potentiated contractions induced by norepinephrine in arteries with and without endothelium of spontaneously hypertensive rats but not Wistar-Kyoto rats.	Norepinephrine	87-101	endothelin 1	Rattus norvegicus	38-50
1737646-10	1992	Thus, angiotensin II stimulates the endothelial production of endothelin in situ and therapy potentiates contractions to norepinephrine in mesenteric resistance arteries of spontaneously hypertensive rats.	Norepinephrine	121-135	angiotensinogen	Rattus norvegicus	6-20
1318205-1	1992	The role of the endothelium in the potentiating action of neuropeptide Y (NPY) to contraction induced by KCl, alpha, beta-methylene ATP (mATP), and noradrenaline (NA) was tested on rat tail arteries.	Norepinephrine	148-161	neuropeptide Y	Rattus norvegicus	58-72
1372610-15	1992	Application of substance P (10(-7) mol l-1) in the pyloric preparations caused a contraction as strong as that induced by noradrenaline or adrenaline.	Norepinephrine	122-135	tachykinin precursor 1	Homo sapiens	15-26
1311009-2	1992	Insulin injection raised epinephrine 16-fold and doubled norepinephrine plasma levels.	Norepinephrine	57-71	insulin	Homo sapiens	0-7
1346528-1	1992	The central cardiovascular and dipsogenic effects of angiotensin II involve interactions with norepinephrine, dopamine, and serotonin.	Norepinephrine	94-108	angiotensinogen	Rattus norvegicus	53-67
1346528-7	1992	In the medulla, 2 microM angiotensin II but not angiotensin-(1-7) significantly increased efflux of substance P (221 +/- 87% of basal) and norepinephrine (130 +/- 17% of basal) during the experimental period.	Norepinephrine	139-153	angiotensinogen	Rattus norvegicus	25-39
1560304-3	1992	We have previously reported that endothelin-1 (ET), a novel potent endothelium-derived vasoconstrictor peptide, increased the contraction of nasal vascular smooth muscle which was caused by administration of noradrenaline (NA) into the bath solution.	Norepinephrine	208-221	endothelin 1	Canis lupus familiaris	33-45
1560304-3	1992	We have previously reported that endothelin-1 (ET), a novel potent endothelium-derived vasoconstrictor peptide, increased the contraction of nasal vascular smooth muscle which was caused by administration of noradrenaline (NA) into the bath solution.	Norepinephrine	208-221	endothelin 1	Canis lupus familiaris	47-49
1318205-1	1992	The role of the endothelium in the potentiating action of neuropeptide Y (NPY) to contraction induced by KCl, alpha, beta-methylene ATP (mATP), and noradrenaline (NA) was tested on rat tail arteries.	Norepinephrine	148-161	neuropeptide Y	Rattus norvegicus	74-77
1318205-7	1992	The noradrenaline response was potentiated by NPY at 500 nM but not at 50 nM.	Norepinephrine	4-17	neuropeptide Y	Rattus norvegicus	46-49
1600191-2	1992	The cuticle-bound phenoloxidase from the white puparium exhibited a pH optimum of 6.5 in phosphate buffer and oxidized a variety of catecholic substrates such as 4-methylcatechol, N-beta-alanyldopamine, dopa, dopamine, N-acetyldopamine, catechol, norepinephrine, 3,4-dihydroxyphenylglycol, 3,4-dihydroxybenzoic acid, and 3,4-dihydroxyphenylacetic acid.	Norepinephrine	247-261	Phox	Drosophila melanogaster	18-31
1611472-0	1992	Angiotensin II evokes noradrenaline release from the paraventricular nucleus in conscious rats.	Norepinephrine	22-35	angiotensinogen	Rattus norvegicus	0-14
1611472-4	1992	injections of pressor doses of ANG II (1 ng and 100 ng) led to significant dose-dependent increases of the noradrenaline (NA) release in the PVN (1 ng: 30.95 +/- 6.01 to 47.38 +/- 6.79 pg/sample, P less than or equal to 0.01; 100 ng: 32.93 +/- 5.38 to 73.18 +/- 11.4 pg/sample, P less than or equal to 0.01).	Norepinephrine	107-120	angiotensinogen	Rattus norvegicus	31-37
1425633-9	1992	The similarity between the changes in concentration of active renin and noradrenaline would suggest that sympathetic nerve activity may have been responsible either for the release of active renin or for the conversion of inactive renin to its active form in the kidney.	Norepinephrine	72-85	renin	Homo sapiens	191-196
1551183-1	1992	Calcitonin gene-related peptide (CGRP), a potent vasodilator, and neuropeptide Y (NPY), a potent vasoconstrictor and potentiator of norepinephrine-induced vasoconstriction, were examined in an animal model of endotoxin shock.	Norepinephrine	132-146	neuropeptide Y	Rattus norvegicus	66-80
1551183-1	1992	Calcitonin gene-related peptide (CGRP), a potent vasodilator, and neuropeptide Y (NPY), a potent vasoconstrictor and potentiator of norepinephrine-induced vasoconstriction, were examined in an animal model of endotoxin shock.	Norepinephrine	132-146	neuropeptide Y	Rattus norvegicus	82-85
1425886-1	1992	Noradrenaline and adrenaline were infused IV at 5 different rates (0.01-0.2 micrograms.kg.min-1) for 30 min to volunteers.	Norepinephrine	0-13	CD59 molecule (CD59 blood group)	Homo sapiens	90-95
1361458-6	1992	Moreover, NPY activates postsynaptic messenger pathways that complement and reinforce those affected by norepinephrine, which is another major neuroregulator of LHRH secretion and which is released as a cotransmitter with NPY in the median eminence.	Norepinephrine	104-118	neuropeptide Y	Rattus norvegicus	10-13
1361458-6	1992	Moreover, NPY activates postsynaptic messenger pathways that complement and reinforce those affected by norepinephrine, which is another major neuroregulator of LHRH secretion and which is released as a cotransmitter with NPY in the median eminence.	Norepinephrine	104-118	neuropeptide Y	Rattus norvegicus	222-225
1730456-7	1992	Elevations in urinary norepinephrine excretion, moreover, were highest in those with the highest fasting levels of insulin and glucose.	Norepinephrine	22-36	insulin	Homo sapiens	115-122
1299208-6	1992	Ang II also facilitates the action of another trophic agent for cardiocytes, which is noradrenaline (NA).	Norepinephrine	86-99	angiotensinogen	Homo sapiens	0-6
1395078-0	1992	Renal renin secretion rate and norepinephrine secretion rate in response to centrally administered angiotensin-II: role of the medial basal forebrain.	Norepinephrine	31-45	angiotensinogen	Rattus norvegicus	99-113
1395078-1	1992	The influence that centrally administered angiotensin-II (ANG-II) and saralasin (SAR) has on renal norepinephrine secretion rate (NESR) and renal renin secretion rate (RSR) were studied.	Norepinephrine	99-113	angiotensinogen	Rattus norvegicus	42-56
1395078-1	1992	The influence that centrally administered angiotensin-II (ANG-II) and saralasin (SAR) has on renal norepinephrine secretion rate (NESR) and renal renin secretion rate (RSR) were studied.	Norepinephrine	99-113	angiotensinogen	Rattus norvegicus	58-64
1425633-9	1992	The similarity between the changes in concentration of active renin and noradrenaline would suggest that sympathetic nerve activity may have been responsible either for the release of active renin or for the conversion of inactive renin to its active form in the kidney.	Norepinephrine	72-85	renin	Homo sapiens	191-196
1382168-4	1992	Recently, we have shown that stimulation of Ang II AT-1 receptors in the circumventricular organs causes a selective release of norepinephrine (NE) in the paraventricular nucleus (PVN) and in the supraoptic nucleus (SON).	Norepinephrine	128-142	angiotensinogen	Homo sapiens	44-50
1382170-2	1992	One of the main stimuli for the secretion of renin present in the renal juxtamedullary cells, but also in some other tissues, is provided by the sympathetic nervous system via the action of norepinephrine on beta 1-adrenoceptors.	Norepinephrine	190-204	renin	Homo sapiens	45-50
1640800-0	1992	Chromogranin A correlates with norepinephrine release rate.	Norepinephrine	31-45	chromogranin A	Homo sapiens	0-14
1312549-14	1992	A subtle activation of the sympathetic nervous system was indicated by a moderate increase in plasma noradrenaline during the ANF infusions.	Norepinephrine	101-114	natriuretic peptide A	Homo sapiens	126-129
1305906-0	1992	Effects of angiotensin II on regional brain noradrenaline metabolism in non-stressed and stressed rats.	Norepinephrine	44-57	angiotensinogen	Rattus norvegicus	11-25
1576090-8	1992	The norepinephrine/epinephrine ratio decreases as epinephrine, prolactin, renin and fatty acids rise.	Norepinephrine	4-18	renin	Homo sapiens	74-79
1328791-2	1992	In the RA preparation, thrombin, as well as the three receptor-related peptides caused a relaxation in tissue that was precontracted with noradrenaline; the basic peptide, SFRGHITR, was inactive either as an agonist or as an antagonist to TRP42-55.	Norepinephrine	138-151	coagulation factor II	Rattus norvegicus	23-31
1377322-0	1992	Differential effects of galanin and neuropeptide Y on extracellular norepinephrine levels in the paraventricular hypothalamic nucleus of the rat: a microdialysis study.	Norepinephrine	68-82	galanin and GMAP prepropeptide	Rattus norvegicus	24-31
1377322-0	1992	Differential effects of galanin and neuropeptide Y on extracellular norepinephrine levels in the paraventricular hypothalamic nucleus of the rat: a microdialysis study.	Norepinephrine	68-82	neuropeptide Y	Rattus norvegicus	36-50
1377322-1	1992	Evidence suggests that the peptides galanin (GAL) and neuropeptide Y (NPY) interact with the amine norepinephrine (NE) in the hypothalamic paraventricular nucleus (PVN) to stimulate feeding behavior.	Norepinephrine	99-113	galanin and GMAP prepropeptide	Rattus norvegicus	36-43
1377322-1	1992	Evidence suggests that the peptides galanin (GAL) and neuropeptide Y (NPY) interact with the amine norepinephrine (NE) in the hypothalamic paraventricular nucleus (PVN) to stimulate feeding behavior.	Norepinephrine	99-113	galanin and GMAP prepropeptide	Rattus norvegicus	45-48
1377322-1	1992	Evidence suggests that the peptides galanin (GAL) and neuropeptide Y (NPY) interact with the amine norepinephrine (NE) in the hypothalamic paraventricular nucleus (PVN) to stimulate feeding behavior.	Norepinephrine	99-113	neuropeptide Y	Rattus norvegicus	54-68
1377322-1	1992	Evidence suggests that the peptides galanin (GAL) and neuropeptide Y (NPY) interact with the amine norepinephrine (NE) in the hypothalamic paraventricular nucleus (PVN) to stimulate feeding behavior.	Norepinephrine	99-113	neuropeptide Y	Rattus norvegicus	70-73
1640800-6	1992	Although the correlation of CgA with plasma norepinephrine was only modest (r = 0.37, p less than 0.05), its correlation with norepinephrine release rate was highly significant (r = 0.58, p less than 0.001).	Norepinephrine	44-58	chromogranin A	Homo sapiens	28-31
1738296-2	1992	ET-1 and ET-3 dose-dependently (10(-9) - 10(-8) M) relaxed vascular strips precontracted with norepinephrine only in the presence of endothelium.	Norepinephrine	94-108	endothelin 1	Homo sapiens	0-13
1553258-5	1992	In the absence of thapsigargin both noradrenaline and caffeine also produced a transient increase of [Ca2+]i.	Norepinephrine	36-49	carbonic anhydrase 2	Rattus norvegicus	102-105
1688277-4	1991	Somatostatin decreases the activity of alpha-adrenergic receptors agonist (norepinephrine), and potentiates the activity of beta-adrenergic receptors agonist (isoprenaline).	Norepinephrine	75-89	somatostatin	Rattus norvegicus	0-12
1579218-10	1992	In the presence of the vasopressin V1-receptor antagonist, d(CH2)5[Tyr(Et)]DAVP, the pressor and heart rate responses to noradrenaline injected into the paraventricular nuclei were abolished, as were the vasoconstrictions in the renal, superior mesenteric and hindquarter vascular beds.	Norepinephrine	121-134	arginine vasopressin	Rattus norvegicus	23-34
1579218-11	1992	Together these results suggest an interaction between the sympathoadrenal system and vasopressin-mediated mechanisms in the cardiovascular responses to noradrenaline injected bilaterally into the paraventricular nuclei of conscious, untreated rats.	Norepinephrine	152-165	arginine vasopressin	Rattus norvegicus	85-96
1553258-8	1992	These results show that thapsigargin releases Ca2+ from the noradrenaline and caffeine-sensitive stores.	Norepinephrine	60-73	carbonic anhydrase 2	Rattus norvegicus	46-49
1594539-1	1992	The aim of this study was to examine the effects of noradrenaline (NA) and prostaglandin F2 alpha (PGF2 alpha) on angiotensin II (AII)-induced contraction and tachyphylaxis in aortic rings of the rat.	Norepinephrine	52-65	angiotensinogen	Rattus norvegicus	114-128
1594539-1	1992	The aim of this study was to examine the effects of noradrenaline (NA) and prostaglandin F2 alpha (PGF2 alpha) on angiotensin II (AII)-induced contraction and tachyphylaxis in aortic rings of the rat.	Norepinephrine	52-65	angiotensinogen	Rattus norvegicus	130-133
1346945-1	1992	Antibodies against tyrosine hydroxylase (TH, the rate-limiting enzyme in norepinephrine synthesis) and dopamine beta-hydroxylase (DBH, the last enzyme in the synthesis) were used for immunohistochemical staining of human brain locus coeruleus sections, obtained postmortem from suicide victims and matched controls.	Norepinephrine	73-87	tyrosine hydroxylase	Homo sapiens	41-43
1810598-11	1991	These results suggest that ET-1 may induce phosphorylation of an unknown protein either without an increase in myoplasmic Ca2 + concentration or, alternatively, with mobilization of intracellular Ca2+ from noradrenaline- and caffeine-insensitive Ca2 + sources, through a mechanism different from that of phorbol ester.	Norepinephrine	206-219	endothelin 1	Rattus norvegicus	27-31
1666552-3	1991	Similar to the noradrenaline exposure, incubation of the cardiomyocytes in the presence of the cytokine TNF alpha (10 U.ml-1) also increases the level of Gi alpha proteins.	Norepinephrine	15-28	tumor necrosis factor	Rattus norvegicus	104-113
1816091-2	1991	Since a number of central neurotransmitters are also known to influence glucose levels and it is likely that CNS insulin receptors act through neurotransmitter mediation, the present study was conducted to investigate the effect of intracerebroventricularly (icv) administered insulin on rat brain dopamine (DA), noradrenaline (NA), serotonin and acetylcholine (ACh) activity in normal and alloxan-induced hyperglycaemic animals.	Norepinephrine	313-326	insulin	Homo sapiens	113-120
1667281-0	1991	Ca2+ channel activation and membrane depolarization mediated by Cl- channels in response to noradrenaline in vascular myocytes.	Norepinephrine	92-105	carbonic anhydrase 2	Rattus norvegicus	0-3
1663458-1	1991	Although both neurokinin A (NKA) and norepinephrine (NE) induced similar maximal contractions in the epididymal and the prostatic site of vas deferens, NKA affected sensitivity more potently than did NE in both sites.	Norepinephrine	37-51	arginine vasopressin	Rattus norvegicus	138-141
1687480-2	1991	In addition, the ICV administration of CRH caused a significant increase in dopamine (DA) and norepinephrine turnover (NE) in various forebrain regions.	Norepinephrine	94-108	corticotropin releasing hormone	Rattus norvegicus	39-42
1723893-8	1991	Significant relationships were observed between CSF CgA-LI and CSF homovanillic acid, acetylcholinesterase, neuropeptide Y-LI and 5-hydroxy-indole acetic acid, but not with CSF norepinephrine or 3-methoxy-4-hydroxyphenylglycol.	Norepinephrine	177-191	chromogranin A	Homo sapiens	52-55
1937665-4	1991	Plasma norepinephrine concentration in the conscious, resting state increased with sodium chloride loading in angiotensin II-infused rats (594 +/- 42 versus 312 +/- 37 pg/ml, p less than 0.01), but it remained unchanged with sodium citrate loading (324 +/- 23 pg/ml).	Norepinephrine	7-21	angiotensinogen	Rattus norvegicus	110-124
1951755-6	1991	Plasma total catecholamine (norepinephrine + epinephrine) was increased in ANG II-salt rats (176 +/- 14 vs. 290 +/- 23 pg/ml, P less than 0.05), but Ca loading decreased plasma catecholamine (182 +/- 13 pg/ml, P less than 0.05).	Norepinephrine	28-42	angiotensinogen	Rattus norvegicus	75-81
1786526-0	1991	Angiotensin II-induced noradrenaline release from anterior hypothalamus in conscious rats: a brain microdialysis study.	Norepinephrine	23-36	angiotensinogen	Rattus norvegicus	0-14
1742021-1	1991	Dopamine beta-hydroxylase (DBH) catalyzes the final step in the biosynthesis of norepinephrine, the principal classic neurotransmitter of peripheral sympathetic neurons.	Norepinephrine	80-94	dopamine beta hydroxylase	Mus musculus	0-25
1742021-1	1991	Dopamine beta-hydroxylase (DBH) catalyzes the final step in the biosynthesis of norepinephrine, the principal classic neurotransmitter of peripheral sympathetic neurons.	Norepinephrine	80-94	dopamine beta hydroxylase	Mus musculus	27-30
1662341-4	1991	Prolonged exposure of the cells to the beta-adrenergic agonists, isoproterenol or noradrenaline, results in a time- and dose-dependent decrease in cell surface ET-1 receptor number.	Norepinephrine	82-95	endothelin 1	Rattus norvegicus	160-164
1836133-4	1991	ANF has been shown to elicit vasodilatation, suppress plasma renin activity, inhibit the synthesis and release of aldosterone, antagonize sympathetically-mediated release of norepinephrine, and promote diuresis and natriuresis.	Norepinephrine	174-188	natriuretic peptide A	Homo sapiens	0-3
1716062-7	1991	A significant reduction (57-79%, P less than 0.05) in norepinephrine and ANG II stimulation was observed with 8- and 16-wk-old WKY tubules incubated in combination with PTH or DA, but only a 3-33% reduction was produced in 8- and 16-wk-old SHR tubules.	Norepinephrine	54-68	parathyroid hormone	Rattus norvegicus	169-172
1833961-2	1991	Since norepinephrine (NE)-containing neurons involved in cardiovascular regulation in the brain are known to coexist with neuropeptide Y (NPY), it is possible that a functional interaction between NPY and NE exists centrally.	Norepinephrine	6-20	neuropeptide Y	Rattus norvegicus	197-200
1658245-7	1991	Application of norepinephrine and isoproterenol also augmented the NGF-mRNA content.	Norepinephrine	15-29	nerve growth factor	Homo sapiens	67-70
1654387-1	1991	In this study we have demonstrated that noradrenaline increases the levels of prostaglandin E2 and prostaglandin I2 (detected as the stable metabolite 6-keto-prostaglandin F1 alpha) synthesized by homogenates of superior cervical ganglia from the adult rat.	Norepinephrine	40-53	dihydrolipoamide S-succinyltransferase	Rattus norvegicus	92-115
1654387-6	1991	The results of these experiments show that, in vitro, noradrenaline stimulates de novo synthesis of prostaglandin E2 and prostaglandin I2 by sympathetic postganglionic neurons.	Norepinephrine	54-67	dihydrolipoamide S-succinyltransferase	Rattus norvegicus	114-137
1653766-7	1991	Our data indicate the existence in hypertensive individuals of a vascular renin-angiotensin system that seems to modulate sympathetic activity through the presynaptic facilitation of norepinephrine release.	Norepinephrine	183-197	renin	Homo sapiens	74-79
1720693-5	1991	This release is enhanced by acetylcholine, cholecystokinin, serotonin and neurotensin, it is reduced by opioid peptides and noradrenaline.	Norepinephrine	124-137	neurotensin	Homo sapiens	74-85
1895963-2	1991	Moreover, norepinephrine has been recently demonstrated to affect glucose homeostasis by decreasing insulin sensitivity.	Norepinephrine	10-24	insulin	Homo sapiens	100-107
1933373-4	1991	However, norepinephrine infusion in combination with ANG II injection restored the drinking response to ANG II in rats with catecholamine depletions of the lamina terminalis region.	Norepinephrine	9-23	angiotensinogen	Rattus norvegicus	104-110
1961256-5	1991	Following high sodium intake, both angiotensin II (100 nmol/l) and angiotensin I (1 mumol/l) caused a marked increase of the electrically evoked noradrenaline overflow.	Norepinephrine	145-158	angiotensinogen	Rattus norvegicus	35-49
1961256-12	1991	The results are in keeping with a sodium-dependent intracardiac formation of angiotensin II which facilitates noradrenaline release from sympathetic nerve terminals.	Norepinephrine	110-123	angiotensinogen	Rattus norvegicus	77-91
1961256-13	1991	Following low sodium intake, cardiac angiotensin II formation is active, as indicated by the suppression of noradrenaline release by angiotensin-converting enzyme inhibitors and the ineffectiveness of exogenous application of angiotensin II.	Norepinephrine	108-121	angiotensinogen	Rattus norvegicus	37-51
1839525-0	1991	[Roles of oxytocin, serotonin and norepinephrine in regulation of prolactin release during stress].	Norepinephrine	34-48	prolactin	Rattus norvegicus	66-75
1864961-0	1991	Exogenous insulin augments in healthy volunteers the cardiovascular reactivity to noradrenaline but not to angiotensin II.	Norepinephrine	82-95	insulin	Homo sapiens	10-17
1924894-4	1991	Centrally administered NPY also increased gastric secretion in the central noradrenaline depleted rats.	Norepinephrine	75-88	neuropeptide Y	Rattus norvegicus	23-26
1945045-2	1991	Type-2 astrocytes showed [Ca2+]i elevation in response to all the substances examined, i.e. carbachol (10(-4) M), histamine (10(-4) M), noradrenaline (10(-4) M), serotonin (10(-4) M), substance P (10(-6) M), vasopressin (10(-6) M) and glutamate (10(-4) M).	Norepinephrine	136-149	tachykinin precursor 1	Homo sapiens	184-195
1945045-2	1991	Type-2 astrocytes showed [Ca2+]i elevation in response to all the substances examined, i.e. carbachol (10(-4) M), histamine (10(-4) M), noradrenaline (10(-4) M), serotonin (10(-4) M), substance P (10(-6) M), vasopressin (10(-6) M) and glutamate (10(-4) M).	Norepinephrine	136-149	arginine vasopressin	Homo sapiens	208-219
1656181-7	1991	The results obtained demonstrate that increased plasma noradrenaline concentrations may participate in rHu-EPO induced blood pressure increases.	Norepinephrine	55-68	erythropoietin	Homo sapiens	107-110
2063779-9	1991	In contrast, norepinephrine in ischemic patients increased significantly from 1.7 +/- 0.2 (control) to 2.6 +/- 0.3 (maximal pacing) and to 3.0 +/- 0.4 nmol/liter (1 minute after pacing), whereas angiotensin II levels increased from 6.2 +/- 1.4 (control) to 9.3 +/- 2.1 pmol/liter (1 minute after pacing, p less than 0.05).	Norepinephrine	13-27	angiotensinogen	Homo sapiens	195-209
1650397-0	1991	Neuropeptide Y: an endogenous inhibitor of norepinephrine-stimulated melatonin secretion in the rat pineal gland.	Norepinephrine	43-57	neuropeptide Y	Rattus norvegicus	0-14
1936111-5	1991	Plasma noradrenaline increased to a greater extent during insulin (1.03 +/- 0.2 to 1.14 +/- 0.8 to 1.27 +/- 0.17 nmol l-1) than control infusion (0.86 +/- 0.09 to 0.97 +/- 0.09 to 0.99 +/- 0.09 nmol 1-1 (P less than 0.01 insulin vs. control).	Norepinephrine	7-20	insulin	Homo sapiens	58-65
1936111-5	1991	Plasma noradrenaline increased to a greater extent during insulin (1.03 +/- 0.2 to 1.14 +/- 0.8 to 1.27 +/- 0.17 nmol l-1) than control infusion (0.86 +/- 0.09 to 0.97 +/- 0.09 to 0.99 +/- 0.09 nmol 1-1 (P less than 0.01 insulin vs. control).	Norepinephrine	7-20	insulin	Homo sapiens	221-228
1839525-1	1991	The stimulating effects of oxytocin (OT), norepinephrine (NE) and serotonin on prolactin (PRL) release in vitro and in vivo have been well documented.	Norepinephrine	42-56	prolactin	Rattus norvegicus	90-93
1839525-1	1991	The stimulating effects of oxytocin (OT), norepinephrine (NE) and serotonin on prolactin (PRL) release in vitro and in vivo have been well documented.	Norepinephrine	42-56	prolactin	Rattus norvegicus	79-88
1649301-8	1991	The putative phospholipase C inhibitor neomycin was significantly less effective (IC50 = 13.0 +/- 5.0, 0.44 +/- 0.09 and 0.89 +/- 0.40 mM) at inhibiting F- than norepinephrine and KCl contractile effects.	Norepinephrine	161-175	LOC100009319	Oryctolagus cuniculus	13-28
2065781-2	1991	Other vasoconstrictors such as [Arg]vasopressin, 5-hydroxytryptamine and norepinephrine induced the tyrosine phosphorylation of the same set of proteins as angiotensin II.	Norepinephrine	73-87	angiotensinogen	Rattus norvegicus	156-170
2042794-4	1991	Human CGRP provoked a transient but significant decrease in systolic and diastolic blood pressure, associated with tachycardia, marked flushing, a significant increase in plasma noradrenaline, adrenaline, and cyclic AMP levels, and a slight, but significant, decrease in serum total calcium.	Norepinephrine	178-191	calcitonin related polypeptide alpha	Homo sapiens	6-10
1860093-1	1991	HYPOTHESIS: Reduction of plasma angiotensin II inhibits release of noradrenaline in response to a sympathetic nervous system stimulus.	Norepinephrine	67-80	angiotensinogen	Homo sapiens	32-46
2036716-5	1991	The overflow of the norepinephrine cotransmitter neuropeptide Y (NPY) was determined by radioimmunoassay and NPY was used as marker for exocytotic release.	Norepinephrine	20-34	neuropeptide Y	Rattus norvegicus	49-63
2036716-5	1991	The overflow of the norepinephrine cotransmitter neuropeptide Y (NPY) was determined by radioimmunoassay and NPY was used as marker for exocytotic release.	Norepinephrine	20-34	neuropeptide Y	Rattus norvegicus	65-68
1646164-6	1991	After enalaprilat, norepinephrine venoarterial difference increased in the renin-secreting kidney (from 264 to 396, SED = 57 pg/ml, p less than 0.05), whereas it increased only slightly in the contralateral kidney (from 149 to 256, SED = 72 pg/ml, NS).	Norepinephrine	19-33	renin	Homo sapiens	75-80
2040704-6	1991	Plasma norepinephrine levels (119 +/- 19 pg/ml during control) rose during both low (258 +/- 25; P less than 0.02) and high (285 +/- 95; P less than 0.01) doses of insulin and recovery (316 +/- 23; P less than 0.01).	Norepinephrine	7-21	insulin	Homo sapiens	164-171
1860093-14	1991	CONCLUSION: By blocking biosynthesis of angiotensin II, converting enzyme inhibition may attenuate baroreceptor-stimulated release of noradrenaline.	Norepinephrine	134-147	angiotensinogen	Homo sapiens	40-54
1891680-8	1991	A subthreshold concentration of ET-1 enhances exogenously applied noradrenaline (NA)-induced contractions, but not endogenous NA-induced contractions caused by transmural electrical stimulation.	Norepinephrine	66-79	endothelin 1	Homo sapiens	32-36
2022407-7	1991	Experiment 2: In the perfused mesenteric circulation, vasoconstrictor responses to norepinephrine, vasopressin, and KCl were enhanced in rats given a slow pressor infusion of angiotensin II, but sensitivity of responses was not altered.	Norepinephrine	83-97	angiotensinogen	Rattus norvegicus	175-189
1855240-7	1991	RESULTS: Sham lesioned animals: central administration of angiotensin-II caused an increase in renal vascular resistance and intrarenal noradrenaline concentration in both the constant pressure and constant flow renal perfusion models.	Norepinephrine	136-149	angiotensinogen	Rattus norvegicus	58-72
2022410-5	1991	In addition, mean urinary norepinephrine excretion was higher in subjects classified as either hyperglycemic (serum fasting glucose greater than or equal to 113 mg/dl) and hyperinsulinemic (serum fasting insulin greater than or equal to 19 microIU/ml) (p = 0.0023) or in subjects classified as either hyperglycemic or hyperinsulinemic (p = 0.0063) than the mean urinary norepinephrine excretion in normal subjects.	Norepinephrine	26-40	insulin	Homo sapiens	177-184
1678716-2	1991	Whilst somatostatin had no direct action on this vessel, it significantly inhibited noradrenaline-induced, but not alpha, beta-methylene ATP-induced, vasoconstriction.	Norepinephrine	84-97	somatostatin	Oryctolagus cuniculus	7-19
2022725-6	1991	As regards the effect of rTNF on vasoconstriction in response to norepinephrine, vasoconstriction was greatest for the smallest arterioles, and did not change 10 min after rTNF administration for any of the three arteriolar orders.	Norepinephrine	65-79	tumor necrosis factor	Rattus norvegicus	25-29
2069780-0	1991	Endothelium-derived and intraneuronal nitric oxide-dependent inhibition of norepinephrine efflux from sympathetic nerves by bradykinin.	Norepinephrine	75-89	kininogen 1	Canis lupus familiaris	124-134
2069780-1	1991	Evidence is presented that bradykinin inhibits norepinephrine efflux from sympathetic nerves innervating canine mesenteric and pulmonary arteries, in part, by releasing endothelium-derived relaxing factor (EDRF) from the vascular endothelium.	Norepinephrine	47-61	kininogen 1	Canis lupus familiaris	27-37
2069780-2	1991	Moreover, in the absence of vascular endothelium, bradykinin also inhibits norepinephrine efflux from the sympathetic nerve terminals innervating these blood vessels.	Norepinephrine	75-89	kininogen 1	Canis lupus familiaris	50-60
2069780-4	1991	In endothelium-rubbed blood vessels the inhibitory effect of bradykinin on norepinephrine efflux is enhanced by increasing extracellular calcium ion ([Ca2+]o) and attenuated by nitrendipine.	Norepinephrine	75-89	kininogen 1	Canis lupus familiaris	61-71
2069780-5	1991	We propose that bradykinin inhibits norepinephrine efflux by stimulating intraneuronal nitric oxide from arginine.	Norepinephrine	36-50	kininogen 1	Canis lupus familiaris	16-26
1678716-4	1991	These results confirm that somatostatin is a neuroregulatory peptide, and suggest that it is modulating vascular sympathetic cotransmission of the rabbit central ear artery by acting both prejunctionally to inhibit transmitter release, and postjunctionally to reduce the action of noradrenaline.	Norepinephrine	281-294	somatostatin	Oryctolagus cuniculus	27-39
1768811-1	1991	It has been suggested that excess parathyroid hormone (PTH) in chronic renal failure (CRF) or chronic administration of PTH to normal rats caused derangements in norepinephrine and phospholipid metabolism of brain synaptosomes, because of an increase in their resting levels of cytosolic calcium which may induce a decrease in synaptosomal content of ATP.	Norepinephrine	162-176	parathyroid hormone	Rattus norvegicus	34-53
1664361-8	1991	Parathyroid hormone increased the vascular resistance, decreased the cardiac output and reduced vascular and pressor responses to norepinephrine in normotensive rats.	Norepinephrine	130-144	parathyroid hormone	Rattus norvegicus	0-19
1664361-9	1991	The parathyroid hormone dramatically decreased vascular resistance, slightly increased the cardiac output and the vascular and pressor responses to norepinephrine in spontaneously hypertensive rats.	Norepinephrine	148-162	parathyroid hormone	Rattus norvegicus	4-23
2059909-0	1991	The mechanism of [3H]noradrenaline release by histamine and its analogs from the rat vas deferens.	Norepinephrine	21-34	arginine vasopressin	Rattus norvegicus	85-88
1831436-0	1991	Unchanged plasma concentrations of endothelin-1 in healthy men during short-term infusions of AMP, dDAVP and of norepinephrine.	Norepinephrine	112-126	endothelin 1	Homo sapiens	35-47
1825749-3	1991	Duct segments were mounted on a myograph, and noncumulative dose-response curves were obtained for the effect of ANP and NP on the rate and force of spontaneous (and norepinephrine-induced) duct contraction.	Norepinephrine	166-180	natriuretic peptide A	Homo sapiens	113-116
2019991-5	1991	Furthermore, endothelium denudation enhanced markedly contraction elicited by NPY in WKY (up to 40% of the maximal effect of norepinephrine), but not in SHR.	Norepinephrine	125-139	neuropeptide Y	Rattus norvegicus	78-81
2019991-6	1991	NPY potentiated the contractile response to low concentrations of norepinephrine (less than 300 nM) in both strains regardless whether the endothelium was intact or not.	Norepinephrine	66-80	neuropeptide Y	Rattus norvegicus	0-3
1901415-8	1991	IL-1 alpha reduced basal LHRH release and blocked LHRH release induced by norepinephrine.	Norepinephrine	74-88	interleukin 1 alpha	Rattus norvegicus	0-10
1825749-4	1991	Both ANP (threshold approximately 1 nM) and NP (threshold approximately 10 nM) in a dose-related fashion reduced the frequency and force of contraction of both spontaneously contracting and norepinephrine-stimulated duct segments.	Norepinephrine	190-204	natriuretic peptide A	Homo sapiens	5-8
1906353-2	1991	NPY often is found colocalized with the classical neurotransmitter norepinephrine (NE) and can potentiate the effects of this neurotransmitter postsynaptically in many systems.	Norepinephrine	67-81	neuropeptide Y	Rattus norvegicus	0-3
1900942-0	1991	Norepinephrine and isoproterenol increase the phosphorylation of synapsin I and synapsin II in dentate slices of young but not aged Fisher 344 rats.	Norepinephrine	0-14	synapsin II	Rattus norvegicus	80-91
1364848-5	1991	NPY (2 x 10(-8) M) increased the sensitivity to noradrenaline (NA) and 5-hydroxytryptamine (5-HT) more in PC (4.2 and 2.8 fold, respectively) than in DC arteries (2.2 and 1.4 fold, respectively).	Norepinephrine	48-61	neuropeptide Y	Rattus norvegicus	0-3
1906353-8	1991	The possible colocalization of NPY and NE in these nerve fibers was investigated by chemical sympathectomy with 6-hydroxydopamine, followed by immunocytochemical labeling of NPY and tyrosine hydroxylase (TH), the rate-limiting enzyme in norepinephrine synthesis.	Norepinephrine	237-251	neuropeptide Y	Rattus norvegicus	31-34
1711980-2	1991	The decrease may be partly dependent on the positive cronotropic and inotropic effects of endothelin-1, since other agents with chronotropic activity (noradrenaline, isoprenaline, serotonin and Bay k 8644) also decreased stimulation-induced chronotropic responses.	Norepinephrine	151-164	endothelin 1	Rattus norvegicus	90-102
1850682-4	1991	Increases in whole-body noradrenaline spillover to arterial plasma were larger (from 282 +/- 40 ng min-1 m-2 to 358 +/- 41 ng min-1 m-2, P less than 0.01) and there was a trend towards an increase in whole-body noradrenaline clearance.	Norepinephrine	24-37	CD59 molecule (CD59 blood group)	Homo sapiens	99-104
1711980-3	1991	Endothelin-1 caused a significant rightward shift of the linear portion of the log concentration-response curve for the chronotropic actions of noradrenaline and isoprenaline.	Norepinephrine	144-157	endothelin 1	Rattus norvegicus	0-12
1850686-9	1991	At rest in the supine position the rate of noradrenaline re-uptake was 474 +/- 122 pmol min-1 kg-1, 9.5-fold higher than the rate of spillover of noradrenaline into plasma (49.6 +/- 6.4 pmol min-1 kg-1).	Norepinephrine	43-56	CD59 molecule (CD59 blood group)	Homo sapiens	88-93
1850686-9	1991	At rest in the supine position the rate of noradrenaline re-uptake was 474 +/- 122 pmol min-1 kg-1, 9.5-fold higher than the rate of spillover of noradrenaline into plasma (49.6 +/- 6.4 pmol min-1 kg-1).	Norepinephrine	43-56	CD59 molecule (CD59 blood group)	Homo sapiens	88-98
1850682-4	1991	Increases in whole-body noradrenaline spillover to arterial plasma were larger (from 282 +/- 40 ng min-1 m-2 to 358 +/- 41 ng min-1 m-2, P less than 0.01) and there was a trend towards an increase in whole-body noradrenaline clearance.	Norepinephrine	24-37	CD59 molecule (CD59 blood group)	Homo sapiens	126-131
1993889-8	1991	Changes in the inositol polyphosphate second messengers are compared with the time course of bradykinin-stimulated increases in free intracellular Ca2+ concentrations and noradrenaline release.	Norepinephrine	171-184	kininogen 1	Homo sapiens	93-103
2015428-6	1991	The concentration of endothelin-1 required to induced contractions equal to 50% of those induced by 1 microM noradrenaline was reduced from 5.8 nM when the vascular endothelium was present to 1.4 nM after it had been mechanically removed.	Norepinephrine	109-122	endothelin 1	Rattus norvegicus	21-33
1864314-3	1991	Simultaneously with the change in blood pressure and heart rate, the concentrations of plasma epinephrine and norepinephrine rose 4 and 10 min after VIP administration.	Norepinephrine	110-124	vasoactive intestinal peptide	Rattus norvegicus	149-152
1824629-4	1991	The administration of d(CH2)5Tyr(Me)AVP, a selective antagonist of the vascular effect of vasopressin, to 10 cirrhotic rats induced a significant reduction in mean arterial pressure (from 94 +/- 4 to 85 +/- 4 mm Hg; P less than 0.001) and a significant increase in plasma renin activity (from 24.3 +/- 4.9 to 34.3 +/- 5.9 ng/mL.h; P less than 0.02) and plasma norepinephrine concentration (from 1474 +/- 133 to 2433 +/- 253 pg/mL; P less than 0.01).	Norepinephrine	360-374	arginine vasopressin	Rattus norvegicus	90-101
1996627-3	1991	Plasma chromogranin A and norepinephrine concentrations were highly correlated when the sympathochromaffin system was activated markedly (cardiac arrest samples, n = 13, r = 0.8392, P less than 0.0005) and when there was release of large amounts of norepinephrine from tumors (pheochromocytoma samples, n = 17, r = 0.8132, P less than 0.001).	Norepinephrine	249-263	chromogranin A	Homo sapiens	7-21
1829510-6	1991	Neither this peptide nor AVP alone did not affect NAT activity, but either substance potentiated the norepinephrine-induced enhancement of NAT activity.	Norepinephrine	101-115	N-acetyltransferase 1	Rattus norvegicus	139-142
1989850-1	1991	Studies in the rat and rabbit indicate that facilitatory effects of neuropeptide Y (NPY) as well as norepinephrine (NE) on LH and LHRH release are dependent on the presence of the ovarian steroid estrogen.	Norepinephrine	100-114	gonadotropin releasing hormone 1	Macaca mulatta	130-134
1671088-2	1991	When the cells were exposed to beta-adrenergic agonists, they accumulated cyclic AMP in the following order of potency: isoproterenol much greater than norepinephrine greater than epinephrine, which is indicative of a beta 1-subtype receptor.	Norepinephrine	152-166	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	218-224
1648383-7	1991	Treatment of our cultures with phorbol myristate acetate, lipopolysaccharide, tumor necrosis factor alpha, and norepinephrine for 24 hours led to only a moderate elevation of endothelin-1 immunoreactivity.	Norepinephrine	111-125	endothelin 1	Rattus norvegicus	175-187
1648497-5	1991	The increase in adenylyl cyclase activity induced by TNF alpha was completely suppressed when the cells were cocultured with noradrenaline, a condition leading to an additive increase in Gi alpha level.	Norepinephrine	125-138	tumor necrosis factor	Rattus norvegicus	53-62
1648497-7	1991	Although TNF alpha, like noradrenaline, exposure of the cells increased the level of membrane Gi alpha proteins, it did not decrease but rather caused an increase in adenylyl cyclase responsiveness.	Norepinephrine	25-38	tumor necrosis factor	Rattus norvegicus	9-18
1847023-10	1991	A subtle increase in plasma concentrations of norepinephrine and epinephrine was observed during the ANF infusions.	Norepinephrine	46-60	natriuretic peptide A	Homo sapiens	101-104
1671041-6	1991	MLC20 phosphorylation induced by norepinephrine was completely inhibited by guanosine 5"-O-(beta-thiodiphosphate) (GDP beta S).	Norepinephrine	33-47	myosin light chain 12B	Homo sapiens	0-5
1801509-2	1991	The decreases found in hypothalamic norepinephrine and dopamine are particularly important since they lead to reduced gonadotropic hormone secretin and cessation of estrous cycles in female rats and a decrease in testosterone secretion in male rats, lower GH and somatomedin (IGF-I) secretion and reduced protein synthesis, diminished thyroid hormone secretion and lower body metabolism, higher PRL secretion and development of numerous mammary and pituitary tumours, and reduced immune competence.	Norepinephrine	36-50	prolactin	Rattus norvegicus	395-398
1801509-3	1991	The reduction in hypothalamic norepinephrine and dopamine activity is believed to be due to damage and loss of neurons owing to toxic products formed during metabolism of norepinephrine and dopamine; to the damaging effects to neurons produced by the chronic action of estrogen, PRL, and indirectly by adrenal glucocorticoids; and to changes in enzymes responsible for synthesis and metabolism of norepinephrine and dopamine.	Norepinephrine	30-44	prolactin	Rattus norvegicus	279-282
1760896-5	1991	The data indicate that a reduction in the activity of the renin-angiotensin-aldosterone system, modulated by circulating norepinephrine and plasma renin substrate, may significantly contribute to the fall in blood pressure associated with weight loss.	Norepinephrine	121-135	renin	Homo sapiens	58-63
2043936-18	1991	Therefore endogenous NPY, like noradrenaline could play a modulatory role in regulating vascular tone and may influence mucosal integrity.	Norepinephrine	31-44	neuropeptide Y	Rattus norvegicus	21-24
1672624-2	1991	Pancreatic islet cells showing this very weak formaldehyde-induced fluorescence react immunohistochemically with antisera directed against insulin, aromatic L-amino acid decarboxylase and dopamine beta-hydroxylase and therefore appear to be islet B cells producing insulin and noradrenaline.	Norepinephrine	277-290	insulin	Gallus gallus	139-146
1846791-3	1991	As insulin activates the sympathetic nervous system, the present study was undertaken to measure the plasma noradrenaline concentration in the fasting state and after 75 g of oral glucose in simple-obese patients (n = 13), in non-insulin-dependent (type 2) diabetic patients (n = 37) and in normal control subjects (n = 12).	Norepinephrine	108-121	insulin	Homo sapiens	3-10
1846791-8	1991	Step-wise regression analysis indicated that independent effects on the fasting plasma noradrenaline concentration were exerted by age (r = +0.32, P = 0.002), glucose concentration (r = -0.32, P = 0.02) and the degree of obesity (r = -0.37, P = 0.007), but not by plasma insulin concentration.	Norepinephrine	87-100	insulin	Homo sapiens	271-278
2022198-4	1991	The concentrations of plasma lactate and counterregulatory hormones at rest were similar at warm and cool temperature, whereas prolactin concentration was higher (P less than 0.01) at +30 degrees C. Exercise resulted in an increase in noradrenaline, growth hormone and prolactin (P less than 0.01), prevented the diurnal decrease in cortisol, but had no effect on glucagon.	Norepinephrine	235-248	prolactin	Homo sapiens	127-136
1984867-1	1991	We tested the hypothesis that pressor infusions of angiotensin II (AII) could stimulate the sympathetic nervous system as reflected by norepinephrine (NE) spillover in humans.	Norepinephrine	135-149	angiotensinogen	Homo sapiens	51-65
1984867-1	1991	We tested the hypothesis that pressor infusions of angiotensin II (AII) could stimulate the sympathetic nervous system as reflected by norepinephrine (NE) spillover in humans.	Norepinephrine	135-149	angiotensinogen	Homo sapiens	67-70
1743243-0	1991	The effect of angiotensin II on haemodynamic and plasma noradrenaline responses to tyramine infusion in man.	Norepinephrine	56-69	angiotensinogen	Homo sapiens	14-28
1725353-2	1991	In endothelium-denuded preparations, a 60-min exposure to 0.3 nM ET-1 had no effect on the basal perfusion pressure, but significantly enhanced responses to stimulation (1 Hz, 10 s) and norepinephrine (10 ng) to 124 +/- 9% (n = 6) and 139 +/- 14% (n = 8), respectively, of control responses.	Norepinephrine	186-200	endothelin 1	Rattus norvegicus	65-69
1725333-0	1991	Endothelin modulates L-NG-nitroarginine-induced enhancement of vasoconstriction evoked by norepinephrine.	Norepinephrine	90-104	endothelin 1	Rattus norvegicus	0-10
1725353-0	1991	Modulation of norepinephrine-induced vasoconstriction by endothelin-1 and nitric oxide in rat tail artery.	Norepinephrine	14-28	endothelin 1	Rattus norvegicus	57-69
1725366-5	1991	The sensitivity to exogenous ET-1 after renal ischemia was decreased, but much less than the sensitivity to angiotensin II, which almost lost its vasoconstrictor effect, and to norepinephrine, which became a vasodilator.	Norepinephrine	177-191	endothelin 1	Rattus norvegicus	29-33
1725422-3	1991	Intracisternal administration of 0.03 nmol ET-1 gave rise to a significant elevation in plasma noradrenaline and adrenaline levels.	Norepinephrine	95-108	endothelin 1	Rattus norvegicus	43-47
1725333-5	1991	Low concentrations of ET-1 (10(-11) and 10(-10) M) potentiated the pressor responses to norepinephrine without affecting the baseline perfusion pressure.	Norepinephrine	88-102	endothelin 1	Rattus norvegicus	22-26
1725333-6	1991	Simultaneous NOARG (10(-5) M) infusion with ET-1 (10(-11) M) into the mesenteric arteries caused further enhancement of the pressor responses to exogenous norepinephrine (200 ng) without affecting the baseline perfusion pressure: 126 +/- 15% to 262 +/- 45% (p less than 0.05, vehicle control: 100%).	Norepinephrine	155-169	endothelin 1	Rattus norvegicus	44-48
1994180-1	1991	An attenuation of adrenergic activity during the inhibition of endogenous angiotensin II formation was evaluated by determining plasma norepinephrine concentration after a single oral administration of captopril compared to that after nifedipine in essential hypertension.	Norepinephrine	135-149	angiotensinogen	Homo sapiens	74-88
2046466-0	1991	Effects of angiotensin II on pressor responses to norepinephrine in humans.	Norepinephrine	50-64	angiotensinogen	Homo sapiens	11-25
2046466-1	1991	In previous studies in the conscious rabbit and in isolated artery preparations, low doses of angiotensin II synergistically amplified the pressor effects of the sympathetic neurotransmitter, norepinephrine (NE).	Norepinephrine	192-206	angiotensinogen	Homo sapiens	94-108
1886454-1	1991	We examined the possible involvement of angiotensin II in the modulation of circulating norepinephrine produced by acute sodium restriction in essential hypertensive patients (n = 18).	Norepinephrine	88-102	angiotensinogen	Homo sapiens	40-54
1886454-3	1991	An intravenous infusion of sarcosine-1, isoleucine-8 angiotensin II produced a significant fall in mean arterial pressure (-6 +/- 2 mmHg, p less than 0.05) in patients on sodium restriction but not before sodium restriction, while the infusion of the antagonist produced a greater decrease (p less than 0.05) in plasma norepinephrine with sodium restriction (-158 +/- 23 pg/ml, p less than 0.05) when compared to that obtained before sodium restriction (-91 +/- 11 pg/ml, p less than 0.05).	Norepinephrine	319-333	angiotensinogen	Homo sapiens	53-67
20504725-5	1991	The ability of endothelin-1 to reduce chronotropic and inotropic responses to noradrenaline was also not different between the two groups.	Norepinephrine	78-91	endothelin 1	Rattus norvegicus	15-27
1710791-4	1991	The norepinephrine turnover in median eminence and anterior hypothalamus was increased in alpha 2u-globulin-injected animals, while the norepinephrine turnover in the remaining medial basal hypothalamus was reduced.	Norepinephrine	4-18	alpha2u globulin	Rattus norvegicus	90-107
20504724-1	1991	The effect of endothelin-1 (ET-1) on the increase in perfusion pressure and the release of noradrenaline produced by electrical field stimulation were examined in isolated perfused/superfused rat tail arteries.	Norepinephrine	91-104	endothelin 1	Rattus norvegicus	28-32
20504724-3	1991	These results show that, besides its postjunctional vasoconstrictor effect, ET-1 exerts in the rat tail artery a prejunctional action which might be involved in the modulation of stimulation-evoked noradrenaline release from postganglionic nerves.	Norepinephrine	198-211	endothelin 1	Rattus norvegicus	76-80
2027469-5	1991	Contents of dopamine and noradrenaline in cultures with interleukin-6 were also larger than in control cultures.	Norepinephrine	25-38	interleukin 6	Rattus norvegicus	56-69
1726027-5	1991	Following systemic administration of DSP-4, there was an almost complete loss of noradrenaline and D beta H staining in brain regions innervated by LC axons.	Norepinephrine	81-94	dual specificity phosphatase 26	Homo sapiens	37-42
2046887-3	1991	The findings revealed that in innervated glands, vasopressin caused 59-74% decrease of norepinephrine (NE) 4 and 24 h after administration while in denervated glands it resulted in 18-65% release of NE 0.5 to 144 h after injection.	Norepinephrine	87-101	arginine vasopressin	Homo sapiens	49-60
1988765-7	1991	Plasma chromogranin A correlated with tumor mass, tumor chromogranin A content, tumor norepinephrine content, and urinary vanillylmandelic acid excretion; it did not correlate with plasma or urinary catecholamines, nor with blood pressure in patients with pheochromocytoma.	Norepinephrine	86-100	chromogranin A	Homo sapiens	7-21
1726027-9	1991	The results reveal a significant difference in the affinity of DSP-4 for the noradrenaline uptake carrier in cortical and hypothalamic synaptosomes.	Norepinephrine	77-90	dual specificity phosphatase 26	Homo sapiens	63-68
1705768-0	1990	Effects of angiotensin II and bilateral nephrectomy on norepinephrine catabolism in central nervous system.	Norepinephrine	55-69	angiotensinogen	Rattus norvegicus	11-25
1705768-1	1990	Effects of angiotensin II (AII) on norepinephrine (NE) catabolism in hypothalamus and medulla oblongata of male rats were studied.	Norepinephrine	35-49	angiotensinogen	Rattus norvegicus	27-30
2176947-14	1990	It increases the blood glucose concentration and the circulating noradrenaline level at an infusion rate of 5 micrograms min-1 kg-1.	Norepinephrine	65-78	CD59 molecule (CD59 blood group)	Homo sapiens	121-131
2249740-1	1990	The precise role of hypothalamic norepinephrine (NE) in the control of vasopressin (AVP) release has remained unclear, due to reports of both inhibitory and excitatory effects of NE and only a few studies with direct hypothalamic manipulations.	Norepinephrine	33-47	arginine vasopressin	Rattus norvegicus	71-82
1962795-8	1990	Norepinephrine-precontracted aorta strips from rats receiving a non-pressor dose of angiotensin II were more sensitive to the relaxant effect of ANF.	Norepinephrine	0-14	angiotensinogen	Rattus norvegicus	84-98
1979763-4	1990	The circulating noradrenaline levels were higher during the infusion of pork insulin which also yielded a more prominent response of pancreatic polypeptide and, after cessation of the insulin infusion, plasma cortisol was also higher following pork insulin.	Norepinephrine	16-29	insulin	Homo sapiens	77-84
2280902-0	1990	Divalent cations effectively replace Ca2+ and support bradykinin induced noradrenaline release.	Norepinephrine	73-86	kininogen 1	Homo sapiens	54-64
2280902-3	1990	Alkaline metals, barium (Ba2+), strontium (Sr2+) and other metal cations, manganese (Mn2+) or lanthanum (La3+), support BK-induced [3H]noradrenaline ([3H]NA) release.	Norepinephrine	135-148	kininogen 1	Homo sapiens	120-122
2261148-5	1990	Postglucose serum insulin correlated positively with plasma norepinephrine (r = 0.75; P = .013) in normotensives, but these parameters correlated negatively in hypertensives (r = -0.7; P = .036).	Norepinephrine	60-74	insulin	Homo sapiens	18-25
2261148-6	1990	We hypothesize that elevated plasma norepinephrine and neuropeptide Y levels reflect an increased level of sympathetic nervous activity in hypertensives, which in turn may be responsible for the abnormal relationship between plasma NE and insulin levels.	Norepinephrine	36-50	insulin	Homo sapiens	239-246
1964826-4	1990	Intra-third ventricular administration of the AII antagonist, Sar1, Ile8-angiotensin II (saralasin) significantly attenuated pressor response and plasma noradrenaline elevation but not plasma ACTH elevation.	Norepinephrine	153-166	angiotensinogen	Rattus norvegicus	46-49
1964826-4	1990	Intra-third ventricular administration of the AII antagonist, Sar1, Ile8-angiotensin II (saralasin) significantly attenuated pressor response and plasma noradrenaline elevation but not plasma ACTH elevation.	Norepinephrine	153-166	angiotensinogen	Rattus norvegicus	73-87
2171909-15	1990	Thus, the secretion of ACTH stimulated by the action of IL-1 beta at the ME depends, in part, on the local secretion of norepinephrine and epinephrine interacting with both alpha and beta adrenergic receptors.	Norepinephrine	120-134	interleukin 1 beta	Rattus norvegicus	56-65
2169395-9	1990	Thus, the secretion of both hypothalamic epinephrine and, to some extent, norepinephrine is involved in the ACTH response to the activation of catecholaminergic neurons in the IV.	Norepinephrine	74-88	proopiomelanocortin	Homo sapiens	108-112
2076491-2	1990	In tissues previously incubated with [3H]-noradrenaline exposure to cocaine (0.1 to 10 microM) or desmethylimipramine (0.01 to 1 microM) produced a concentration-dependent increase (up to 2 fold) in electrically evoked (3 Hz, 2 ms, 20 mA, 120s every 20 min) fractional overflow of tritium from rat brain cortex slices but not from mouse vas deferens (2.5 Hz, 2 ms, 400 mA, for 90s every 14 min).	Norepinephrine	42-55	arginine vasopressin	Rattus norvegicus	337-340
2171935-1	1990	The reaction of myeloperoxidase with biologically active polyhydroxyphenols (substituted catechols): catecholamine, norepinephrine and 2,4,5-trihydroxyphenylalanine [Phe(OH)3] were investigated by using the ESR spin-stabilization technique and rapid-scan spectrophometry in the millisecond time scale.	Norepinephrine	116-130	myeloperoxidase	Homo sapiens	16-31
2169395-6	1990	Because controversy exists about the effect of DCMB as an alpha 2 adrenoreceptor antagonist in vivo, this was examined by administering norepinephrine into the third ventricle after DCMB ip; DCMB significantly reduced the ACTH response to norepinephrine 0.2 micrograms (P less than 0.05) but not to 0.5 micrograms.	Norepinephrine	239-253	proopiomelanocortin	Homo sapiens	222-226
2241966-4	1990	Conversely, endothelin-1 and U46619 potentiated the responses of both the arterial and venous vessels to exogenous noradrenaline.	Norepinephrine	115-128	endothelin 1	Rattus norvegicus	12-24
1699553-0	1990	Neuropeptide Y and galanin enhance the inhibitory effects of clonidine on norepinephrine release from medulla oblongata of rats.	Norepinephrine	74-88	neuropeptide Y	Rattus norvegicus	0-26
1699553-2	1990	Neuropeptide Y (NPY) and galanin (Gal) coexist with norepinephrine (NE) and may have a functional interaction in this region.	Norepinephrine	52-66	neuropeptide Y	Rattus norvegicus	0-14
1699553-2	1990	Neuropeptide Y (NPY) and galanin (Gal) coexist with norepinephrine (NE) and may have a functional interaction in this region.	Norepinephrine	52-66	neuropeptide Y	Rattus norvegicus	16-19
1699553-2	1990	Neuropeptide Y (NPY) and galanin (Gal) coexist with norepinephrine (NE) and may have a functional interaction in this region.	Norepinephrine	52-66	galanin and GMAP prepropeptide	Rattus norvegicus	25-32
1699553-2	1990	Neuropeptide Y (NPY) and galanin (Gal) coexist with norepinephrine (NE) and may have a functional interaction in this region.	Norepinephrine	52-66	galanin and GMAP prepropeptide	Rattus norvegicus	34-37
1978793-2	1990	In this work, we have studied the effect of several concentrations of prolactin on the synthesis, storage and release of norepinephrine and epinephrine using cultured bovine adrenal chromaffin cells.	Norepinephrine	121-135	prolactin	Bos taurus	70-79
2129867-5	1990	We propose that the DBH/NPY/NGF-R-positive adrenal medullary ganglion cells are sympathetic postganglionic neurons producing noradrenaline.	Norepinephrine	125-138	neuropeptide Y	Rattus norvegicus	24-27
2177835-1	1990	UNLABELLED: The effect of pituitary human growth hormone (hGH) on the 32P-labelling of phosphoinositides and phosphatidic acid was studied in noradrenaline-stimulated rat adipocytes which were either responsive or non-responsive to the antilipolytic (insulin-like) effect of hGH.	Norepinephrine	142-155	growth hormone 1	Homo sapiens	42-56
2393132-9	1990	In the Ca2(+)-free medium the contractile response to norepinephrine was greatly attenuated as compared to control, whereas the oscillatory behavior was completely abolished.	Norepinephrine	54-68	carbonic anhydrase 2	Oryctolagus cuniculus	7-10
2086189-4	1990	But, positive correlation between left ventricular mass and plasma norepinephrine was observed both in SHT group and SNT group.	Norepinephrine	67-81	fibroblast growth factor receptor substrate 2	Homo sapiens	117-120
2130600-10	1990	These results indicate that norepinephrine completely depletes caffeine-sensitive Ca2 stores but caffeine only partially depletes norepinephrine-sensitive Ca2+ stores.	Norepinephrine	28-42	carbonic anhydrase 2	Rattus norvegicus	82-85
2151360-0	1990	Atrial natriuretic peptide and angiotensin II interaction on noradrenaline uptake in the central nervous system.	Norepinephrine	61-74	angiotensinogen	Homo sapiens	31-45
2151360-1	1990	The effects of different concentrations of atrial natriuretic peptide and angiotensin II on [3H]-noradrenaline uptake in hypothalamus and medulla oblongata slices incubated in vitro were determined.	Norepinephrine	97-110	angiotensinogen	Homo sapiens	74-88
2151360-3	1990	The ineffective concentration of 1 nM atrial natriuretic peptide reversed the action of 1 microM of angiotensin II on [3H]-noradrenaline uptake, whereas ineffective concentrations of angiotensin II failed to modify atrial natriuretic peptide effects.	Norepinephrine	123-136	angiotensinogen	Homo sapiens	100-114
2166759-2	1990	In our study we have determined that UK-14304 (UK) and norepinephrine (NE), both alpha 2-adrenergic agonists, can augment LPS-stimulated TNF from elicited macrophages (MO).	Norepinephrine	55-69	tumor necrosis factor	Homo sapiens	137-140
2130600-10	1990	These results indicate that norepinephrine completely depletes caffeine-sensitive Ca2 stores but caffeine only partially depletes norepinephrine-sensitive Ca2+ stores.	Norepinephrine	130-144	carbonic anhydrase 2	Rattus norvegicus	155-158
2243613-3	1990	Insulin caused depletion of more norepinephrine (NE) from the denervated glands 0.5 h after treatment.	Norepinephrine	33-47	insulin	Homo sapiens	0-7
1696258-6	1990	Studies with norepinephrine in combination with various adrenergic receptor antagonists revealed that the induction of Egr-1 is primarily an alpha 1-mediated, pertussis toxin-insensitive response.	Norepinephrine	13-27	early growth response 1	Rattus norvegicus	119-124
1704616-7	1990	In light of other pharmacological and anatomical evidence, it is suggested the PVN GAL, in modulating feeding behavior, may work in association with the catecholamine norepinephrine (NE) which is known to coexist with GAL in PVN neurons.	Norepinephrine	167-181	galanin and GMAP prepropeptide	Rattus norvegicus	83-86
1704616-7	1990	In light of other pharmacological and anatomical evidence, it is suggested the PVN GAL, in modulating feeding behavior, may work in association with the catecholamine norepinephrine (NE) which is known to coexist with GAL in PVN neurons.	Norepinephrine	167-181	galanin and GMAP prepropeptide	Rattus norvegicus	218-221
2172886-2	1990	As a parameter for the change of the Adenylcyclase activity we determined the Adenylcyclase stimulatability caused by the neurotransmitters noradrenaline, dopamine and adrenaline.	Norepinephrine	140-153	adenylate cyclase 1	Homo sapiens	37-50
2207507-13	1990	Threshold concentrations of endothelin-1 potentiated the contractions evoked by low and moderate concentrations of noradrenaline (10(-7) - 10(-6) M) in old, but not in young, rats.	Norepinephrine	115-128	endothelin 1	Rattus norvegicus	28-40
2222975-1	1990	Norepinephrine blood pressure reactivity is reduced in uremia, an effect attributed to excess parathyroid hormone (PTH).	Norepinephrine	0-14	parathyroid hormone	Homo sapiens	94-113
2222975-1	1990	Norepinephrine blood pressure reactivity is reduced in uremia, an effect attributed to excess parathyroid hormone (PTH).	Norepinephrine	0-14	parathyroid hormone	Homo sapiens	115-118
2222975-2	1990	Most, but not all, animal and human studies support the theory that high PTH levels diminish the pressor response to norepinephrine.	Norepinephrine	117-131	parathyroid hormone	Homo sapiens	73-76
2222975-4	1990	Excess parathyroid hormone appears to play an active role in reduced vascular responsiveness to norepinephrine, although the mechanisms of this effect are unknown.	Norepinephrine	96-110	parathyroid hormone	Homo sapiens	7-26
2172886-2	1990	As a parameter for the change of the Adenylcyclase activity we determined the Adenylcyclase stimulatability caused by the neurotransmitters noradrenaline, dopamine and adrenaline.	Norepinephrine	140-153	adenylate cyclase 1	Homo sapiens	78-91
2171719-1	1990	The effect of the noradrenergic neurotoxin DSP-4 on high affinity transport of noradrenaline (NAT) was studied using rat brain synaptosomes.	Norepinephrine	79-92	N-acetyltransferase 1	Rattus norvegicus	94-97
2171719-4	1990	Differences in NAT into cortical and hypothalamic synaptosomes were also observed with noradrenaline itself (Km = 39.5 +/- 7.5 nM and 100 +/- 12.1 nM, respectively) and with the catecholamine uptake blocker mazindol (Ki = 0.55 +/- 0.05 nM and 0.30 +/- 0.08 nM, respectively).	Norepinephrine	87-100	N-acetyltransferase 1	Rattus norvegicus	15-18
2163775-2	1990	We have previously demonstrated that atrial natriuretic peptide (ANP) completely reverses norepinephrine-induced afferent arteriolar (AA) vasoconstriction.	Norepinephrine	90-104	natriuretic peptide A	Homo sapiens	65-68
1700398-4	1990	The action of NT was mimicked by norepinephrine (NE), but not by opioid peptides, somatostatin, or vasoactive intestinal peptide.	Norepinephrine	33-47	neurotensin	Sus scrofa	14-16
2194695-0	1990	Threshold concentrations of endothelin-1 potentiate contractions to norepinephrine and serotonin in human arteries.	Norepinephrine	68-82	endothelin 1	Homo sapiens	28-40
2194695-5	1990	In mammary artery rings, the contractions to norepinephrine (3 x 10(-8) M) were potentiated by threshold (3 x 10(-10) M) and low concentrations (10(-9) M) of endothelin-1 (96 +/- 35% and 149 +/- 58% increase from control; p less than 0.01 and 0.001; n = 6).	Norepinephrine	45-59	endothelin 1	Homo sapiens	158-170
2194695-7	1990	The calcium antagonist darodipine (10(-7) M) prevented the potentiation of the response to norepinephrine evoked by endothelin-1.	Norepinephrine	91-105	endothelin 1	Homo sapiens	116-128
2380655-2	1990	Angiotensin II increased noradrenaline release and the production of hydroxy- and methoxyindoles by pineal slices.	Norepinephrine	25-38	angiotensinogen	Rattus norvegicus	0-14
2203597-4	1990	The increase in circulating gamma 2-MSH-LI levels preceded the elevation of the venous plasma noradrenaline level, but did not rise further with more pronounced activation of the sympathetic nervous system at the highest grade of physical activity examined.	Norepinephrine	94-107	proopiomelanocortin	Homo sapiens	36-39
1693949-1	1990	Dopamine-beta-hydroxylase (DBH), the enzyme that catalyzes the conversion of dopamine to norepinephrine, remains the topic of many unanswered questions.	Norepinephrine	89-103	dopamine beta-hydroxylase	Bos taurus	0-25
1693949-1	1990	Dopamine-beta-hydroxylase (DBH), the enzyme that catalyzes the conversion of dopamine to norepinephrine, remains the topic of many unanswered questions.	Norepinephrine	89-103	dopamine beta-hydroxylase	Bos taurus	27-30
2169424-0	1990	Effects of neuropeptide Y on norepinephrine release in hypothalamic slices of spontaneously hypertensive rats.	Norepinephrine	29-43	neuropeptide Y	Rattus norvegicus	11-25
1975832-11	1990	It is well known that catecholamine, especially noradrenaline has an inhibiting action on insulin secretion from beta cell.	Norepinephrine	48-61	insulin	Homo sapiens	90-97
1971535-2	1990	(-)Norepinephrine produced stimulation predominantly through beta 1-receptors and (-)epinephrine through both beta 1- and beta 2-receptors.	Norepinephrine	3-17	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	61-67
2384133-0	1990	The neuropeptides vasoactive intestinal polypeptide, peptide histidine isoleucine and neuropeptide Y modulate [3H]noradrenaline release from sympathetic nerves in the choroid plexus.	Norepinephrine	114-127	neuropeptide Y	Sus scrofa	86-100
2140540-7	1990	Changes in plasma norepinephrine concentrations reflected these sympathetic nerve responses to ANF.	Norepinephrine	18-32	natriuretic peptide A	Homo sapiens	95-98
2206914-6	1990	The role of renal nerves and neuronally released norepinephrine on renin secretion in the developing kidney is discussed.	Norepinephrine	49-63	renin	Ovis aries	67-72
1973038-3	1990	Similarly, tyrosine hydroxylase and dopamine beta-hydroxylase, which reflect the presence of noradrenaline, were colocalized with neuropeptide Y.	Norepinephrine	93-106	neuropeptide Y	Rattus norvegicus	130-144
1971535-2	1990	(-)Norepinephrine produced stimulation predominantly through beta 1-receptors and (-)epinephrine through both beta 1- and beta 2-receptors.	Norepinephrine	3-17	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	110-116
2190926-4	1990	A subpressor dose of endothelin-1 (10(-10) M) enhanced the pressor response to norepinephrine; its effect was greater in WKY rats than in SHR.	Norepinephrine	79-93	endothelin 1	Rattus norvegicus	21-33
2189622-2	1990	Studies of left main coronary artery occlusion in isolated perfused rat hearts have shown that the ACE inhibitor captopril reduced reperfusion ventricular fibrillation from 100% to 0% and was associated with a reduction in purine overflow and in norepinephrine release.	Norepinephrine	246-260	angiotensin I converting enzyme	Rattus norvegicus	99-102
1972138-1	1990	Neuropeptide Y is colocalized with norepinephrine in both central and peripheral noradrenergic neurons.	Norepinephrine	35-49	neuropeptide Y	Rattus norvegicus	0-14
1972138-2	1990	In this study, we examined the regulatory mechanisms of neuropeptide Y on norepinephrine release in the medulla oblongata of rats.	Norepinephrine	74-88	neuropeptide Y	Rattus norvegicus	56-70
1972138-5	1990	The blockade of alpha 2-adrenergic receptors by RX 781,094 diminished inhibitory effects of neuropeptide Y on norepinephrine release.	Norepinephrine	110-124	neuropeptide Y	Rattus norvegicus	92-106
2190926-7	1990	Endothelin-1 inhibited norepinephrine release from rat mesenteric arteries; the inhibition was significantly less in SHR than in WKY rats.	Norepinephrine	23-37	endothelin 1	Rattus norvegicus	0-12
1972138-6	1990	Pretreatment of pertussis toxin (a toxin that interferes with the coupling of inhibitory receptors to adenylate cyclase) attenuated the suppression of norepinephrine release by neuropeptide Y.	Norepinephrine	151-165	neuropeptide Y	Rattus norvegicus	177-191
2365484-6	1990	Plasma renin release showed a significant correlation with noradrenaline release in the patients with MVD (r = 0.47, p less than 0.01); but this relationship was lost in the patients with the CAD, due to an excessive noradrenaline release.	Norepinephrine	59-72	renin	Homo sapiens	7-12
1972138-7	1990	In spontaneously hypertensive rats, the inhibitory effect of UK 14,304 and neuropeptide Y on norepinephrine release from the medulla oblongata was significantly less than in age-matched Wistar-Kyoto rats.	Norepinephrine	93-107	neuropeptide Y	Rattus norvegicus	75-89
1972138-8	1990	These results show that neuropeptide Y inhibits norepinephrine release partially mediated by alpha 2-adrenergic receptors and the pertussis toxin-sensitive guanosine triphosphate-binding proteins in rat medulla oblongata.	Norepinephrine	48-62	neuropeptide Y	Rattus norvegicus	24-38
2217667-13	1990	Treatment of both patients with the synthetic amino acid, d-l-threo-dihydroxyphenylserine, which contains a hydroxyl group and is converted to noradrenaline by dopa-decarboxylase, reduced symptoms and signs of postural hypotension and increased levels of plasma noradrenaline and its urinary metabolites.	Norepinephrine	143-156	dopa decarboxylase	Homo sapiens	160-178
2200184-2	1990	VIP receptors are coupled to cAMP-generating systems that are amplified by various neurotransmitters such as noradrenaline, histamine and GABA.	Norepinephrine	109-122	vasoactive intestinal peptide	Homo sapiens	0-3
2165434-3	1990	The most prominent effects of norepinephrine were distinct and consistent increases in the labelling of two proteins (37 kDa, pI = 6.0, 50 kDa, pI = 6.0), designated adrenergically induced protein (AIP 37/6 and AIP 50/6).	Norepinephrine	30-44	ADP ribosylation factor like GTPase 6 interacting protein 6	Rattus norvegicus	198-220
2356747-11	1990	Arterial and femoral venous noradrenaline increased during CWT, while changes during WIT were small.	Norepinephrine	28-41	CWT	Bos taurus	59-62
2188755-5	1990	Endothelin-1 induced a slowly developing and sustained contraction, with an EC50 value (half-maximal effective concentration) of 2.9 x 10(-9) M, two orders of magnitude smaller than that of norepinephrine (EC50 of 3.9 x 10(-7) M), indicating that the vasoconstrictor action of endothelin-1 is about 100 times more potent than that of norepinephrine.	Norepinephrine	334-348	endothelin 1	Homo sapiens	0-12
2385755-1	1990	When an adenosine analogue, N6-(amido-3-propyl) adenosine hydrochloride (Agr 529) is administered systemically, it causes a substantial release of epinephrine (E) by the adrenal medulla with no change in plasma norepinephrine (NE) levels.	Norepinephrine	211-225	agrin	Rattus norvegicus	73-76
2341411-7	1990	Noradrenaline induced a rise in both total and arachidonate-containing phosphatidic acid at both times as did vasopressin.	Norepinephrine	0-13	arginine vasopressin	Rattus norvegicus	110-121
2159229-2	1990	Catecholamines stimulated lipolysis in an affinity sequence typical of the beta 1-adrenoceptor subtype: one-half maximum velocity (1/2 Vmax) isoproterenol (35 nM) much greater than 1/2 Vmax norepinephrine (150 nM) approximately 1/2 Vmax epinephrine (200 nM).	Norepinephrine	190-204	adrenoceptor beta 1	Rattus norvegicus	75-94
1972647-3	1990	A neuromodulatory interaction that has been linked to memory function and which has been the subject of biochemical inquiry is the interaction between the catecholamine, norepinephrine (NE) and the neuropeptide, vasopressin (AVP).	Norepinephrine	170-184	arginine vasopressin	Homo sapiens	212-223
1972647-4	1990	Studies described in this report show that vasopressin acts to potentiate norepinephrine (NE)-induced cyclic adenosine monophosphate (cAMP) accumulation in the hippocampus by a calcium-dependent mechanism.	Norepinephrine	74-88	arginine vasopressin	Homo sapiens	43-54
1972647-8	1990	By using vasopressin potentiation of noradrenalin-induced cAMP formation as a model system, I have applied the theoretical framework of associative learning and memory to test the hypothesis that neuromodulation can serve as a biochemical analog of associative cognitive events.	Norepinephrine	37-49	arginine vasopressin	Homo sapiens	9-20
2365484-6	1990	Plasma renin release showed a significant correlation with noradrenaline release in the patients with MVD (r = 0.47, p less than 0.01); but this relationship was lost in the patients with the CAD, due to an excessive noradrenaline release.	Norepinephrine	217-230	renin	Homo sapiens	7-12
2107881-8	1990	These data indicate that the stimulation of phospholipase C activity in rat hepatocytes by 3 nM vasopressin is enhanced by cyclic AMP-dependent kinase but inhibited by protein kinase C. In contrast, down regulation of protein kinase C markedly enhanced the maximal phosphoinositide response due to both vasopressin and norepinephrine.	Norepinephrine	319-333	arginine vasopressin	Rattus norvegicus	96-107
1694249-8	1990	Moreover, the effect is somewhat specific for SP since the activities of tyrosine hydroxylase, tryptophan hydroxylase, and choline acetyltransferase (enzymes in the biosynthetic pathways for norepinephrine, serotonin, and acetylcholine) are not similarly elevated.	Norepinephrine	191-205	tyrosine hydroxylase	Homo sapiens	73-93
2158742-1	1990	Abnormalities in norepinephrine (NE) metabolism of brain synaptosomes occur in chronic renal failure (CRF), and this has been attributed to the parathyroid hormone (PTH)-induced accumulation of calcium in synaptosomes.	Norepinephrine	17-31	parathyroid hormone	Rattus norvegicus	144-163
2196966-8	1990	As with endothelin-1, reactivity to noradrenaline and potassium chloride was increased in MVBs, but not in aortic rings of SHR.	Norepinephrine	36-49	endothelin 1	Rattus norvegicus	8-20
2199951-13	1990	Dual localization of NPY in noradrenergic and nonnoradrenergic fibers and differences in subcellular LDV storage help explain why enkephalin correlates better than NPY with norepinephrine loss in response to acute CNS ischemia.	Norepinephrine	173-187	neuropeptide Y	Sus scrofa	21-24
2322580-3	1990	After 5 h of acute cold or noradrenaline administration there is a 2-fold increase in lipoprotein lipase mRNA abundance, whereas lipoprotein lipase activity is stimulated to more than 6-fold the basal values.	Norepinephrine	27-40	lipoprotein lipase	Rattus norvegicus	86-104
2170177-1	1990	I. v. administration of angiotensin II (0.1, 0.3 and 1.0 microgram/kg/min for 5 min) raised the plasma norepinephrine level in the right atrium and carotid artery in a reverse dose-dependent manner.	Norepinephrine	103-117	angiotensinogen	Rattus norvegicus	24-38
2170177-3	1990	The plasma norepinephrine level was decreased and the veno-arterial difference was similar to basal level at 1.0 microgram/kg/min dose of angiotensin II for 40 min.	Norepinephrine	11-25	angiotensinogen	Rattus norvegicus	138-152
2170177-4	1990	Angiotensin II seems to affect the lung uptake and inactivation of norepinephrine in phasic manner.	Norepinephrine	67-81	angiotensinogen	Rattus norvegicus	0-14
1968893-6	1990	Whole body noradrenaline spillover, a potentially more accurate measure of overall sympathetic activity than concentration of noradrenaline in plasma, was 235 +/- 20 ng min-1 m-2 in controls, was similar in subjects with stable angina (no beta-blockers; 260 +/- 34 ng min-1 m-2, beta-blockers; 200 +/- 17 ng min-1 m-2), but was increased in patients with unstable angina (310 +/- 27 ng min-1 m-2, P less than 0.05), with recent acute myocardial infarction (346 +/- 40 ng min-1 m-2, P less than 0.05) or with heart failure (438 +/- 65 ng min-1 m-2, P less than 0.01).	Norepinephrine	11-24	CD59 molecule (CD59 blood group)	Homo sapiens	169-174
2322238-7	1990	These observations demonstrate that neuronal cells in primary culture have the ability to synthesize [3H]-CA from [3H]-Tyr, and that Ang-II has a receptor-mediated biphasic influence on newly synthesized [3H]-CA (norepinephrine and dopamine).	Norepinephrine	213-227	angiotensinogen	Rattus norvegicus	133-139
2156447-10	1990	A submaximal dose of norepinephrine only slightly blunted the effect of PTH or ANG II.	Norepinephrine	21-35	angiotensinogen	Rattus norvegicus	79-85
2313290-3	1990	Neurotensin also formed a complex with 4-ethylcatechol, 4-methylcatechol, 3-methoxytyramine, and norepinephrine.	Norepinephrine	97-111	neurotensin	Homo sapiens	0-11
2184065-3	1990	During exercise, increments (increase from the resting value to the value at 80% of maximal working capacity) in renin (1.5 +/- 0.4 nmol.l-1.h-1 and 3.7 +/- 0.5 nmol.l-1.h-1; p less than 0.001), angiotensin II (28 +/- 8 nmol/l and 60 +/- 8 nmol/l; p less than 0.001), aldosterone (0.16 +/- 0.04 nmol/l and 0.25 +/- 0.05 nmol/l; p less than 0.05), adrenaline (1.96 +/- 0.49 nmol/l and 2.92 +/- 0.51 nmol/l; p less than 0.05), and noradrenaline (12.01 +/- 1.25 nmol/l and 18.74 +/- 1.45 nmol/l; p less than 0.01) were significantly lower in the patients than in control subjects.	Norepinephrine	429-442	renin	Homo sapiens	113-118
2161754-9	1990	Finally, in the parotid gland, stimulation of amylase secretion by norepinephrine, the physiological mediator, which stimulates both the alpha and beta adrenoceptors, requires the interaction of both Ca2+ and cAMP pathways to produce a full secretory response.	Norepinephrine	67-81	carbonic anhydrase 2	Oryctolagus cuniculus	200-203
1969726-3	1990	However, when AT II was reinfused, it resulted in only 2.1, 2.2, 2.3, 1.9 and 2.4-fold increases, respectively, after infusion of methoxamine, norepinephrine, metaraminol, epinephrine, and phenylephrine.	Norepinephrine	143-157	angiotensinogen	Rattus norvegicus	14-19
2138208-6	1990	A significant correlation was observed between gamma 2-MSH-LI and noradrenaline, and between h-alpha ANP-LI and noradrenaline in patients with CHF.	Norepinephrine	66-79	proopiomelanocortin	Homo sapiens	55-58
2138208-7	1990	The present results show that gamma 2-MSH-LI is increased only in severe forms of cardiac failure, and that this change is more closely related to the increase in circulating levels of noradrenaline than to increased levels of ANP-LI or AVP-LI.	Norepinephrine	185-198	proopiomelanocortin	Homo sapiens	38-41
1692097-1	1990	Effects of Bay K 8644, partial depolarization with high potassium, and nifedipine on the dose-response curves of the rat vas deferens to norepinephrine, methacholine and KCI were investigated in HEPES-buffered physiological salt solution (PSS) with or without 20 mM sodium bicarbonate.	Norepinephrine	137-151	arginine vasopressin	Rattus norvegicus	121-124
2110272-1	1990	A synthetic amino acid, L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS), can be converted to (-)-norepinephrine (NE) by aromatic L-amino acid decarboxylase (AADC) in various mammalian tissues.	Norepinephrine	94-112	dopa decarboxylase	Homo sapiens	130-156
2110272-1	1990	A synthetic amino acid, L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS), can be converted to (-)-norepinephrine (NE) by aromatic L-amino acid decarboxylase (AADC) in various mammalian tissues.	Norepinephrine	94-112	dopa decarboxylase	Homo sapiens	158-162
2313596-6	1990	Functional antagonism was demonstrated by its blockage of angiotensin II (3 X 10(-8) M)-induced 45Ca++ efflux in rat aortic smooth muscle cells with an IC50 of 2 X 10(-8) M. In rabbit aorta, DuP 753 antagonized the contractile response to angiotensin II competitively with a pA2 value of 8.48 but had no effect on the responses induced by norepinephrine or KCl.	Norepinephrine	339-353	angiotensinogen	Rattus norvegicus	58-72
1970270-8	1990	In the absence of a calcium channel blocking agent, NPY (100 nM) produced a leftward shift of the concentration-response curves to noradrenaline (pD2 increased from 6.2 +/- 0.06 to 6.5 +/- 0.05) and phenylephrine (pD2 increased from 5.6 +/- 0.03 to 6.0 +/- 0.06 and from 6.0 +/- 0.06 to 6.3 +/- 0.11).	Norepinephrine	131-144	neuropeptide Y	Rattus norvegicus	52-55
2404819-5	1990	The plasticity of growth responses seen in liver may be controlled by these factors as well as by comitogenic substances such as norepinephrine which, although nonmitogenic per se, can initiate growth in hepatocytes exposed to the above mitogenic growth factors or mitogenic inhibitors such as TGF beta.	Norepinephrine	129-143	transforming growth factor beta 1	Homo sapiens	294-302
2157452-0	1990	Procholecystokinin and proenkephalin A mRNA expression is modulated by cyclic AMP and noradrenaline.	Norepinephrine	86-99	proenkephalin	Homo sapiens	23-38
1970212-3	1990	However, during recent years both ATP and NPY have been suggested to be co-transmitters to noradrenaline in these nerves.	Norepinephrine	91-104	neuropeptide Y	Rattus norvegicus	42-45
2176518-5	1990	Plasma noradrenaline concentration increased during rHu-EPO compared with pretreatment values, while dry weights were unchanged during the study.	Norepinephrine	7-20	erythropoietin	Homo sapiens	56-59
2404624-13	1990	During high-intensity exercise, peak plasma norepinephrine and CgA levels correlated, suggesting that gradations in norepinephrine release represented gradations in exocytosis.	Norepinephrine	116-130	chromogranin A	Homo sapiens	63-66
2150010-5	1990	An association between norepinephrine (NE) and ANF was also present, but in a multivariate analysis it was not significant.	Norepinephrine	23-37	natriuretic peptide A	Homo sapiens	47-50
2405151-16	1990	However, in the latter preparation precontracted with norepinephrine, ET-1, in contrast to acetylcholine, failed to evoke vasorelaxation.	Norepinephrine	54-68	endothelin 1	Rattus norvegicus	70-74
2406102-0	1990	Plasma noradrenaline and dopamine in renin-mediated hypertension.	Norepinephrine	7-20	renin	Homo sapiens	37-42
2323836-6	1990	Percent increase of norepinephrine in the VWF+ group was the highest while that in VWF- group followed and that in the control group was the lowest.	Norepinephrine	20-34	von Willebrand factor	Homo sapiens	42-45
2392201-0	1990	Prospective effect of norepinephrine infusion in acute renal insufficiency induced by interleukin 2 therapy.	Norepinephrine	22-36	interleukin 2	Homo sapiens	86-99
1709150-4	1990	The increase in serum GH and IGF-I was associated with significantly decreased hypothalamic turnover of norepinephrine (NE).	Norepinephrine	104-118	insulin-like growth factor I	Mesocricetus auratus	29-34
2202630-5	1990	In some very rare circumstances (with high plasmatic levels of norepinephrine), insulin sensitivity seems to be enhanced by captopril.	Norepinephrine	63-77	insulin	Homo sapiens	80-87
2303915-10	1990	The smaller norepinephrine pool observed in organs of -Cu mice may have resulted from lower synthesis due to limiting dopamine-beta-monooxygenase activity and to higher turnover.	Norepinephrine	12-26	dopamine beta hydroxylase	Mus musculus	118-145
2166181-6	1990	The VWF(+) group and the VWF(-) group had larger % increases of plasma norepinephrine, cyclic AMP, cyclic GMP, T3 and T4 levels than the control group.	Norepinephrine	71-85	von Willebrand factor	Homo sapiens	4-7
2166181-6	1990	The VWF(+) group and the VWF(-) group had larger % increases of plasma norepinephrine, cyclic AMP, cyclic GMP, T3 and T4 levels than the control group.	Norepinephrine	71-85	von Willebrand factor	Homo sapiens	25-37
2167223-5	1990	Norepinephrine stimulated NAT activity in vitro in a dose-dependent manner, but did not elevate SR numbers.	Norepinephrine	0-14	N-acetyltransferase 1	Rattus norvegicus	26-29
2215932-1	1990	Neuropeptide Y co-exists with noradrenaline in the majority of the sympathetic nerves supplying cerebral blood vessels.	Norepinephrine	30-43	neuropeptide Y	Rattus norvegicus	0-14
2320711-0	1990	DSP-4-induced depletion of brain norepinephrine produces opposite effects on exploratory behavior 3 and 14 days after treatment.	Norepinephrine	33-47	dual specificity phosphatase 26	Homo sapiens	0-5
2320711-8	1990	The simplest explanation for the time dependent effects of DSP-4 on exploratory behavior is the occurrence of the slow development of a supersensitivity of cerebral systems affected by norepinephrine.	Norepinephrine	185-199	dual specificity phosphatase 26	Homo sapiens	59-64
33770644-1	2021	In brain astrocytes, noradrenaline (NA) has been shown to up-regulate IL-6 production via beta-adrenoceptors (ARs).	Norepinephrine	21-34	interleukin 6	Rattus norvegicus	70-74
33798975-3	2021	Clonidine, an alpha2-adrenergic agonist, reduces the release of norepinephrine and has been suggested as a treatment for PTSD.	Norepinephrine	64-78	glycoprotein hormone subunit alpha 2	Homo sapiens	14-20
33805843-8	2021	We found that A30P*A53T*alpha-Syn mice at 4-5 months of age showed 3.5-fold increases in human alpha-Syn expression in dopamine (DA) and norepinephrine (NE) neurons of the substantia nigra pars compacta (SNc) and locus coeruleus (LC), respectively, compared with mouse alpha-Syn levels.	Norepinephrine	137-151	joined toes	Mus musculus	30-33
18823757-3	2008	Sult4A1 is related to metabolism of monoamines, particularly dopamine and norepinephrine, both of which have been implicated in the pathophysiology of the psychopathology and cognitive dysfunction components of schizophrenia.	Norepinephrine	74-88	sulfotransferase family 4A member 1	Homo sapiens	0-7
1670902-4	1991	Plasma renin decreased with bucindolol therapy, from 11.6 +/- 13.4 to 4.3 +/- 4.1 ng/ml/hour (mean +/- standard deviation; p less than 0.05), whereas plasma norepinephrine was unchanged, from 403 +/- 231 to 408 +/- 217 pg/ml.	Norepinephrine	157-171	renin	Homo sapiens	7-12
2215932-9	1990	In conclusion, neuropeptide Y in cerebrovascular nerves is co-stored not only with noradrenaline in sympathetic nerves from the superior cervical ganglion, but also with acetylcholine (reflected in the presence of choline acetyltransferase) and vasoactive intestinal polypeptide in parasympathetic nerves originating in the sphenopalatine, otic, and internal carotid ganglia.	Norepinephrine	83-96	neuropeptide Y	Rattus norvegicus	15-29
2408110-8	1990	It is concluded that NPY-containing nerve fibers have a dual origin in the choroid plexus and coexist with either noradrenaline or VIP/PHI.	Norepinephrine	114-127	neuropeptide Y	Sus scrofa	21-24
34735928-0	2022	Corrigendum to "The stress hormone norepinephrine promotes tumor progression through beta2-adrenoreceptors in oral cancer" (Arch.	Norepinephrine	35-49	ATPase H+ transporting V0 subunit a2	Homo sapiens	85-90
7649580-1	1995	The aim of this study was to investigate angiotensin II (Ang II) receptor-, bradykinin receptor-, and beta-adrenergic receptor-mediated modulation of norepinephrine release from human renal sympathetic nerves and to characterize the respective receptor subtypes involved.	Norepinephrine	150-164	angiotensinogen	Homo sapiens	41-55
7649580-1	1995	The aim of this study was to investigate angiotensin II (Ang II) receptor-, bradykinin receptor-, and beta-adrenergic receptor-mediated modulation of norepinephrine release from human renal sympathetic nerves and to characterize the respective receptor subtypes involved.	Norepinephrine	150-164	angiotensinogen	Homo sapiens	57-63
7649580-1	1995	The aim of this study was to investigate angiotensin II (Ang II) receptor-, bradykinin receptor-, and beta-adrenergic receptor-mediated modulation of norepinephrine release from human renal sympathetic nerves and to characterize the respective receptor subtypes involved.	Norepinephrine	150-164	kininogen 1	Homo sapiens	76-86
34906897-6	2022	Understanding of the effector mechanism is incomplete, but it probably involves a very local action of neurally released noradrenaline on beta2 adrenoceptors on the surface of tissue resident macrophages and other innate immune cells.	Norepinephrine	121-134	ATPase H+ transporting V0 subunit a2	Homo sapiens	138-143
34967939-4	2021	The primary outcomes of this analysis were association between norepinephrine/cumulative catecholamines doses and neuron specific enolase (NSE)/lactate concentration over the first 72 hours after resuscitation.	Norepinephrine	63-77	enolase 2	Homo sapiens	114-137
34967939-4	2021	The primary outcomes of this analysis were association between norepinephrine/cumulative catecholamines doses and neuron specific enolase (NSE)/lactate concentration over the first 72 hours after resuscitation.	Norepinephrine	63-77	enolase 2	Homo sapiens	139-142
34970413-5	2021	The norepinephrine (NE) triggered beta 2-AR to activate the FOXO1/NF-kappaB pathway, which induced endometrial inflammation.	Norepinephrine	4-18	forkhead box O1	Homo sapiens	60-65
34970413-5	2021	The norepinephrine (NE) triggered beta 2-AR to activate the FOXO1/NF-kappaB pathway, which induced endometrial inflammation.	Norepinephrine	4-18	nuclear factor kappa B subunit 1	Homo sapiens	66-75
34668531-0	2021	AMPK activation by SC4 inhibits noradrenaline-induced lipolysis and insulin-stimulated lipogenesis in white adipose tissue.	Norepinephrine	32-45	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	0-4
34571056-6	2021	Furthermore, a decrease of the levels of the key enzyme (TH) and transporter (VMAT2) of norepinephrine was evident both by western blot analysis and immunofluorescence.	Norepinephrine	88-102	tyrosine hydroxylase	Homo sapiens	57-59
34899395-3	2021	These results indicated that in fed rats an increased adrenergic tonus blocked food intake, since the activation of alpha-2 auto-receptors, which decreases pre-synaptic release of adrenaline/noradrenaline, affected food intake.	Norepinephrine	191-204	UDP glucuronosyltransferase 1 family, polypeptide A7C	Rattus norvegicus	116-123
34614428-2	2021	Angiotensin II causes constriction of arterioles and venules, inhibits the reuptake of norepinephrine, stimulates the release of catecholamines, and hypertrophy of vascular smooth muscle cells.	Norepinephrine	87-101	angiotensinogen	Homo sapiens	0-14
34668531-8	2021	Therefore in WAT, AMPK activation inhibits noradrenaline-induced lipolysis and suppresses insulin-stimulated lipogenesis primarily by inactivating ACC and by inhibiting glucose uptake.	Norepinephrine	43-56	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	18-22
34829630-7	2021	Consistently, EA mimics clonidine in inhibiting noradrenaline exocytosis from hippocampal nerve endings in a yohimbine-sensitive fashion that confirms the engagement of naive alpha2-ARs in the EA-mediated effect.	Norepinephrine	48-61	glycoprotein hormone subunit alpha 2	Homo sapiens	175-181
34474105-4	2021	Here, we show that the arachidonate-derived metabolite produced by stress-activated leukocyte 12/15-lipoxygenase is remarkably elevated in the plasma and upregulates the central norepinephrine release, resulting in the enhancement of the struggle behaviour (= escape behaviour) in the tail suspension test.	Norepinephrine	178-192	arachidonate 15-lipoxygenase	Homo sapiens	94-112
34713714-8	2021	The effects of norepinephrine on the expression of GLP-1R and neprilysin in kidney epithelial LLC-PK1 cells were also examined.	Norepinephrine	15-29	membrane metalloendopeptidase	Sus scrofa	62-72
34474105-8	2021	Our findings indicate that arachidonate-derived 12/15-lipoxygenase metabolite is involved in the regulation of stress-enhanced central norepinephrine release and struggle behaviour.	Norepinephrine	135-149	arachidonate 15-lipoxygenase	Mus musculus	48-66
34609854-5	2021	In neonatal murine cardiac fibroblasts, norepinephrine increased reactive oxygen species (ROS), accumulation of catechol-modified protein adducts, expression and secretion of collagens I/III, and other markers of profibrotic activation including STAT3 phosphorylation.	Norepinephrine	40-54	signal transducer and activator of transcription 3	Mus musculus	246-251
34609854-9	2021	Collectively, these findings suggest that norepinephrine may influence extracellular matrix remodeling via an adrenergic-independent redox pathway in cardiac fibroblasts involving the MAO-mediated generation of ROS, catecholaldehydes, and RAGE.	Norepinephrine	42-56	advanced glycosylation end product-specific receptor	Mus musculus	239-243
34363644-8	2021	Notably, oral spermidine upregulated tyrosine hydroxylase in hypothalamus of HFD-fed mice; spermidine treatment increased tyrosine hydroxylase expression and norepinephrine production in neurocytes, which led to CREB activation and UCP-1 induction in brown adipocytes and myotubes.	Norepinephrine	158-172	cAMP responsive element binding protein 1	Mus musculus	212-216
34392133-1	2021	Tramadol, a weak mu-opioid receptor (MOR) agonist with inhibitory effects on the reuptake of serotonin (5-hydroxytryptamine; 5-HT) and norepinephrine, is an effective analgesic to chronic pains.	Norepinephrine	135-149	opioid receptor, mu 1	Mus musculus	17-35
34411733-12	2021	Glypican 1 may be a potential target for the development of new therapies for resistant hypertension or conditions where norepinephrine levels are increased.	Norepinephrine	121-135	glypican 1	Mus musculus	0-10
34597293-0	2021	Separable actions of acetylcholine and noradrenaline on neuronal ensemble formation in hippocampal CA3 circuits.	Norepinephrine	39-52	carbonic anhydrase 3	Homo sapiens	99-102
34597293-7	2021	Thus, through these distinct sets of mechanisms, acetylcholine and noradrenaline facilitate the formation of neuronal ensembles in CA3 that encode salient episodic memories in the hippocampus but acetylcholine selectively enhances the density of memory storage.	Norepinephrine	67-80	carbonic anhydrase 3	Homo sapiens	131-134
34582425-8	2022	The odds of in-hospital mortality increased 20.7% for every 10 microg/min increase in norepinephrine-equivalent dose up to 60 microg/min at the time of vasopressin initiation (adjusted odds ratio, 1.21 (95% CI, 1.09-1.34)), but no association was detected when the norepinephrine-equivalent dose exceeded 60 microg/min (adjusted odds ratio, 0.96 (95% CI, 0.84-1.10)).	Norepinephrine	86-100	arginine vasopressin	Homo sapiens	152-163
34582425-11	2022	CONCLUSIONS: Higher norepinephrine-equivalent dose at vasopressin initiation and higher lactate concentration at vasopressin initiation were each associated higher in-hospital mortality in patients with septic shock who received vasopressin.	Norepinephrine	20-34	arginine vasopressin	Homo sapiens	54-65
34582425-11	2022	CONCLUSIONS: Higher norepinephrine-equivalent dose at vasopressin initiation and higher lactate concentration at vasopressin initiation were each associated higher in-hospital mortality in patients with septic shock who received vasopressin.	Norepinephrine	20-34	arginine vasopressin	Homo sapiens	229-240
34630037-3	2021	Dopamine-beta-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline and consequently, DBH inhibition reduces catecholamines.	Norepinephrine	72-85	dopamine beta hydroxylase	Mus musculus	0-25
34630037-3	2021	Dopamine-beta-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline and consequently, DBH inhibition reduces catecholamines.	Norepinephrine	72-85	dopamine beta hydroxylase	Mus musculus	27-30
34630037-3	2021	Dopamine-beta-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline and consequently, DBH inhibition reduces catecholamines.	Norepinephrine	72-85	dopamine beta hydroxylase	Mus musculus	104-107
34392133-1	2021	Tramadol, a weak mu-opioid receptor (MOR) agonist with inhibitory effects on the reuptake of serotonin (5-hydroxytryptamine; 5-HT) and norepinephrine, is an effective analgesic to chronic pains.	Norepinephrine	135-149	opioid receptor, mu 1	Mus musculus	37-40
34440433-7	2021	The pharmacogenetic variables response to serotonin-norepinephrine reuptake inhibitors (SNRIs) (ABCB1) and reduced metabolism of quetiapine (CYP3A4) predicted patient response to these medications, respectively.	Norepinephrine	52-66	ATP binding cassette subfamily B member 1	Homo sapiens	96-101
34099360-8	2021	Via its inhibitory and excitatory effects on neurons and microglia, noradrenaline sometimes prevents and sometimes accelerates the production and accumulation of amyloid-beta and tau in various brain regions.	Norepinephrine	68-81	amyloid beta precursor protein	Homo sapiens	162-174
33031192-3	2021	The hemodynamic response to angiotensin II was estimated by recording the mean arterial pressure, norepinephrine equivalent dose (NED) and urine output.	Norepinephrine	98-112	angiotensinogen	Homo sapiens	28-42
34193040-5	2021	Concentration-response curves for norepinephrine, phenylephrine, metaraminol and vasopressin were constructed.	Norepinephrine	34-48	arginine vasopressin	Rattus norvegicus	81-92
34281286-0	2021	Norepinephrine Protects against Methamphetamine Toxicity through beta2-Adrenergic Receptors Promoting LC3 Compartmentalization.	Norepinephrine	0-14	UDP glucuronosyltransferase 1 family, polypeptide A7C	Rattus norvegicus	65-70
34275002-16	2021	In both groups, control group and cultures taken from subjects with ADHD, the expression of the periodic genes (Per1-3) was significantly influenced by incubation with norepinephrine.	Norepinephrine	168-182	period circadian regulator 1	Homo sapiens	112-118
34080124-1	2021	BACKGROUND: Solute carrier (SLC) 22 A1, A2, and A3 are polyspecific transporters transporting organic cations like histamine, serotonin, norepinephrine, dopamine, MPP + , and toxins.	Norepinephrine	137-151	solute carrier family 22 member 1	Homo sapiens	12-38
35426141-1	2022	STUDY OBJECTIVES: The objective of this study was to develop and externally validate a model to predict adjunctive vasopressin response in patients with septic shock being treated with norepinephrine for bedside use in the intensive care unit.	Norepinephrine	185-199	arginine vasopressin	Homo sapiens	115-126
34004054-11	2021	Further analyses revealed that GCN2 activation in macrophages reduced the expression of monoamine oxidase A (MAOA), resulting in increased norepinephrine (NE) secretion from macrophages to adipocytes, and this resulted in enhanced WAT browning and lipolysis.	Norepinephrine	139-153	eukaryotic translation initiation factor 2 alpha kinase 4	Mus musculus	31-35
34423298-9	2021	The use of alpha-2 agonists with the potential to reduce noradrenaline release needs further examination.	Norepinephrine	57-70	glycoprotein hormone subunit alpha 2	Homo sapiens	11-18
34062902-5	2021	We utilized cell lines overexpressing alpha1A-, alpha1B- or alpha1D-ARs to investigate the effects of the antidepressants imipramine (IMI), desipramine (DMI), mianserin (MIA), reboxetine (REB), citalopram (CIT) and fluoxetine (FLU) on noradrenaline-induced second messenger generation by those receptors.	Norepinephrine	235-248	serpin family A member 1	Homo sapiens	38-45
34812056-8	2021	The in vitro experiments revealed that treatments with norepinephrine markedly increased mRNAs and proteins of ATF2 and CBP/p300 and reduced mRNA and proteins of HDAC2 and HDAC5 in MN9D cells.	Norepinephrine	55-69	activating transcription factor 2	Mus musculus	111-115
34812056-8	2021	The in vitro experiments revealed that treatments with norepinephrine markedly increased mRNAs and proteins of ATF2 and CBP/p300 and reduced mRNA and proteins of HDAC2 and HDAC5 in MN9D cells.	Norepinephrine	55-69	histone deacetylase 2	Mus musculus	162-167
34812056-8	2021	The in vitro experiments revealed that treatments with norepinephrine markedly increased mRNAs and proteins of ATF2 and CBP/p300 and reduced mRNA and proteins of HDAC2 and HDAC5 in MN9D cells.	Norepinephrine	55-69	histone deacetylase 5	Mus musculus	172-177
34812056-9	2021	A ChIP assay showed that norepinephrine significantly increased CBP/p300 binding or reduced HDAC2 and HDAC5 binding on the TH promoter.	Norepinephrine	25-39	histone deacetylase 2	Mus musculus	92-97
34812056-9	2021	A ChIP assay showed that norepinephrine significantly increased CBP/p300 binding or reduced HDAC2 and HDAC5 binding on the TH promoter.	Norepinephrine	25-39	histone deacetylase 5	Mus musculus	102-107
35426141-6	2022	Vasopressin response was defined as survival with at least a 20% decrease in maximum daily norepinephrine requirements by one calendar day after vasopressin initiation, without a third-line vasopressor.	Norepinephrine	91-105	arginine vasopressin	Homo sapiens	0-11
35628613-0	2022	Regulator of G-Protein Signaling-4 Attenuates Cardiac Adverse Remodeling and Neuronal Norepinephrine Release-Promoting Free Fatty Acid Receptor FFAR3 Signaling.	Norepinephrine	86-100	free fatty acid receptor 3	Mus musculus	144-149
35628613-2	2022	Free fatty acid receptor (FFAR)-3, also known as GPR41, is a Gi/o protein-coupled receptor (GPCR) that mediates some of the propionate"s actions in cells, such as inflammation, fibrosis, and increased firing/norepinephrine release from peripheral sympathetic neurons.	Norepinephrine	208-222	free fatty acid receptor 3	Mus musculus	0-33
35628613-2	2022	Free fatty acid receptor (FFAR)-3, also known as GPR41, is a Gi/o protein-coupled receptor (GPCR) that mediates some of the propionate"s actions in cells, such as inflammation, fibrosis, and increased firing/norepinephrine release from peripheral sympathetic neurons.	Norepinephrine	208-222	free fatty acid receptor 3	Mus musculus	49-54
35628613-8	2022	Finally, RGS4 opposes FFAR3-dependent norepinephrine release from sympathetic-like neurons (differentiated Neuro-2a cells) co-cultured with H9c2 cardiomyocytes, thereby preserving the functional betaAR number of the cardiomyocytes.	Norepinephrine	38-52	regulator of G-protein signaling 4	Mus musculus	9-13
35628613-8	2022	Finally, RGS4 opposes FFAR3-dependent norepinephrine release from sympathetic-like neurons (differentiated Neuro-2a cells) co-cultured with H9c2 cardiomyocytes, thereby preserving the functional betaAR number of the cardiomyocytes.	Norepinephrine	38-52	free fatty acid receptor 3	Mus musculus	22-27
35171852-9	2022	CONCLUSIONS: In cardiac surgery patients with hypotonia and postoperative high Delta-renin levels, AT-II was associated with reduced renin plasma levels for at 12 hours and significantly decreased norepinephrine use, while norepinephrine alone was associated with increased renin levels.	Norepinephrine	197-211	angiotensinogen	Homo sapiens	99-104
35589612-0	2022	Norepinephrine activates beta1 -adrenergic receptors at the inner nuclear membrane in astrocytes.	Norepinephrine	0-14	BCL2 related protein A1	Homo sapiens	25-30
35526604-4	2022	STUDY DESIGN AND METHODS: Using the Medical Information Mart in Intensive Care (MIMIC)-IV database, we identified patients with sepsis and AF at the time norepinephrine or phenylephrine initiation.	Norepinephrine	154-168	septin 4	Homo sapiens	56-60
35152290-11	2022	Nadir CBG levels were associated with higher SOFA cardiovascular scores and norepinephrine total dose (mug; P < 0.01) and duration (days; P < 0.01).	Norepinephrine	76-90	serpin family A member 6	Homo sapiens	6-9
35152290-13	2022	CONCLUSION: Septic shock patients with CBG < 200 nmol/L had higher norepinephrine requirements and 3.2-fold higher ICU mortality.	Norepinephrine	67-81	serpin family A member 6	Homo sapiens	39-42
35232218-6	2022	Net norepinephrine-induced vasoconstriction was exaggerated in adults with MDD (-0.16+-0.54 HA versus -0.75+-0.56 au MDD, P=0.014); however, there were no group differences in angiotensin II-induced vasoconstriction.	Norepinephrine	4-18	angiotensinogen	Homo sapiens	176-190
35514336-2	2022	Noradrenaline is released from sympathetic terminals and activates beta1-and beta2-adrenergic receptors (AlphaRs) located at the plasma membrane of pacemaker cells.	Norepinephrine	0-13	BCL2 related protein A1	Homo sapiens	67-72
35192730-9	2022	The biopterin, BH4, and norepinephrine contents were increased in penile homogenates from BH4-supplemented Spr-/- mice, and the TH protein levels tended to increase, and their nitrite plus nitrate levels were significantly lower than those of vehicle-treated Spr-/- mice and were approximately the same as vehicle- and BH4-supplemented Spr+/+ mice.	Norepinephrine	24-38	sepiapterin reductase	Mus musculus	107-110
35514336-2	2022	Noradrenaline is released from sympathetic terminals and activates beta1-and beta2-adrenergic receptors (AlphaRs) located at the plasma membrane of pacemaker cells.	Norepinephrine	0-13	ATPase H+ transporting V0 subunit a2	Homo sapiens	77-82
35217815-11	2022	In norepinephrine-treated HUVECs, we showed that trimetazidine significantly increased the phosphorylation of Akt and the synergistic nuclear translocation of Akt and HSF1, as well as the binding of Akt and HSF1 in the nucleus.	Norepinephrine	3-17	thymoma viral proto-oncogene 1	Mus musculus	110-113
35099408-7	2022	Time-course assay showed that stimulation of oral SCC cells with norepinephrine decreased the cleavage of caspase-3 and expression of MDR-1 but only transiently affected ABCG2 expression.	Norepinephrine	65-79	caspase 3	Homo sapiens	106-115
35099408-7	2022	Time-course assay showed that stimulation of oral SCC cells with norepinephrine decreased the cleavage of caspase-3 and expression of MDR-1 but only transiently affected ABCG2 expression.	Norepinephrine	65-79	ATP binding cassette subfamily B member 1	Homo sapiens	134-139
35099408-7	2022	Time-course assay showed that stimulation of oral SCC cells with norepinephrine decreased the cleavage of caspase-3 and expression of MDR-1 but only transiently affected ABCG2 expression.	Norepinephrine	65-79	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	170-175
35099408-8	2022	The expression of cleaved caspase-3 and bcl-2 were, respectively, decreased and increased by the combination of norepinephrine and cisplatin in SCC-9 and Cal27 cells.	Norepinephrine	112-126	caspase 3	Homo sapiens	26-35
35099408-8	2022	The expression of cleaved caspase-3 and bcl-2 were, respectively, decreased and increased by the combination of norepinephrine and cisplatin in SCC-9 and Cal27 cells.	Norepinephrine	112-126	BCL2 apoptosis regulator	Homo sapiens	40-45
35099408-10	2022	Expressions of ABCG2, and p-Akt but not of MDR-1, were enhanced by norepinephrine plus cisplatin when compared to cisplatin only in both cell lines.	Norepinephrine	67-81	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	15-20
35099408-10	2022	Expressions of ABCG2, and p-Akt but not of MDR-1, were enhanced by norepinephrine plus cisplatin when compared to cisplatin only in both cell lines.	Norepinephrine	67-81	AKT serine/threonine kinase 1	Homo sapiens	28-31
35099408-12	2022	These findings reveal for the first time that stress hormone norepinephrine induce resistance of oral cancer cells to cisplatin in vitro through the ADRB/Akt/ABCG2 pathway, pumping the drug out of the cell and inhibiting apoptosis.	Norepinephrine	61-75	AKT serine/threonine kinase 1	Homo sapiens	154-157
35099408-12	2022	These findings reveal for the first time that stress hormone norepinephrine induce resistance of oral cancer cells to cisplatin in vitro through the ADRB/Akt/ABCG2 pathway, pumping the drug out of the cell and inhibiting apoptosis.	Norepinephrine	61-75	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	158-163
35219305-0	2022	Norepinephrine promotes glioma cell migration through up-regulating the expression of Twist1.	Norepinephrine	0-14	twist family bHLH transcription factor 1	Homo sapiens	86-92
35210489-5	2022	Our ex vivo efflux experiments reveal that the NE transporter (NET) blocker desipramine elevates both norepinephrine (NE) and dopamine (DA), but not 5-HT levels, in PFC tissue slices from wild-type (WT) and DAT-KO, but not NET-KO mice.	Norepinephrine	102-116	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	207-210
35327387-10	2022	CONCLUSION: We demonstrate signs of UCP1-dependent norepinephrine-induced thermogenesis connected with higher expression of DIO2, PPARGC1A, CEBPB and PRDM16 in retroperitoneal VAT of PPGL and its relations to circulating HDLc and triglycerides levels.	Norepinephrine	51-65	PPARG coactivator 1 alpha	Homo sapiens	130-138
35284140-6	2022	In addition, despite no significant correlations between plasma levels of NGF and catecholamines in both groups, urinary NGF significantly correlated positively with both urinary noradrenaline and urinary adrenaline in the hypertensive group (r = 0.259, p=0.018 and r = 0.232, p=0.035), but not in the normotensive group (r = 0.115, p=0.307 and r = -0.018, p=0.871).	Norepinephrine	179-192	nerve growth factor	Homo sapiens	121-124
35217815-11	2022	In norepinephrine-treated HUVECs, we showed that trimetazidine significantly increased the phosphorylation of Akt and the synergistic nuclear translocation of Akt and HSF1, as well as the binding of Akt and HSF1 in the nucleus.	Norepinephrine	3-17	thymoma viral proto-oncogene 1	Mus musculus	159-162
35217815-11	2022	In norepinephrine-treated HUVECs, we showed that trimetazidine significantly increased the phosphorylation of Akt and the synergistic nuclear translocation of Akt and HSF1, as well as the binding of Akt and HSF1 in the nucleus.	Norepinephrine	3-17	thymoma viral proto-oncogene 1	Mus musculus	199-202
35079095-3	2022	Here we show that norepinephrine (NE) secretion from ICA cells is increased through activation of Toll-like receptor 4 (TLR4) to aggravate myocardial TNF-alpha production and dysfunction by lipopolysaccharide (LPS).	Norepinephrine	18-32	tumor necrosis factor	Homo sapiens	150-159
35156051-11	2022	For each 0.1 unit the pH was below 7.40 at vasopressin initiation, the norepinephrine-equivalent catecholamine dose increased by 1.5 microg/min (95% CI, 0.5-2.5 microg/min) at 1 hour, and increased by 2.5 microg/min (95% CI, 1.4-3.5 microg/min) at 6 hours after vasopressin initiation.	Norepinephrine	71-85	arginine vasopressin	Homo sapiens	43-54
35156051-11	2022	For each 0.1 unit the pH was below 7.40 at vasopressin initiation, the norepinephrine-equivalent catecholamine dose increased by 1.5 microg/min (95% CI, 0.5-2.5 microg/min) at 1 hour, and increased by 2.5 microg/min (95% CI, 1.4-3.5 microg/min) at 6 hours after vasopressin initiation.	Norepinephrine	71-85	arginine vasopressin	Homo sapiens	262-273
35054851-2	2022	This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA.	Norepinephrine	72-86	interferon gamma	Homo sapiens	137-153
35054851-2	2022	This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA.	Norepinephrine	72-86	interferon gamma	Homo sapiens	155-164
35054851-2	2022	This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA.	Norepinephrine	72-86	CD4 molecule	Homo sapiens	225-228
35054851-2	2022	This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA.	Norepinephrine	352-366	interferon gamma	Homo sapiens	137-153
34996979-4	2022	To identify the MAO-B substrate in PVT, we generated Maob knockout (KO) mice and measured five candidate substrates (i.e., noradrenaline, dopamine, 3-methoxytyramine, serotonin, and phenethylamine (PEA)) by liquid chromatography tandem mass spectrometry.	Norepinephrine	123-136	monoamine oxidase B	Mus musculus	16-21
35054851-2	2022	This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA.	Norepinephrine	352-366	interferon gamma	Homo sapiens	155-164
35054851-3	2022	Norepinephrine suppressed IL-17 and IFN-gamma production by the anti-CD3/anti-CD28-microbead-stimulated CD4+ T cells in both groups.	Norepinephrine	0-14	interferon gamma	Homo sapiens	36-45
35054851-3	2022	Norepinephrine suppressed IL-17 and IFN-gamma production by the anti-CD3/anti-CD28-microbead-stimulated CD4+ T cells in both groups.	Norepinephrine	0-14	CD4 molecule	Homo sapiens	104-107
35054851-8	2022	These data illustrate the inhibitory effect of norepinephrine on IL-17 and IFN-gamma production by CD4+ T cells in MS.	Norepinephrine	47-61	interferon gamma	Homo sapiens	75-84
35054851-8	2022	These data illustrate the inhibitory effect of norepinephrine on IL-17 and IFN-gamma production by CD4+ T cells in MS.	Norepinephrine	47-61	CD4 molecule	Homo sapiens	99-102
35054851-9	2022	The inhibitory effect of norepinephrine on IFN-gamma production by CD4+ T cells in MS could be mediated via beta2-adrenoreceptor activation.	Norepinephrine	25-39	interferon gamma	Homo sapiens	43-52
35054851-9	2022	The inhibitory effect of norepinephrine on IFN-gamma production by CD4+ T cells in MS could be mediated via beta2-adrenoreceptor activation.	Norepinephrine	25-39	CD4 molecule	Homo sapiens	67-70
35046893-11	2021	The NLRP3 agonist blocked the noradrenaline degradation-reducing effect of ES, and an increase in lipolysis via the inhibition of the NLRP3 inflammasome attenuated NAMs.	Norepinephrine	30-43	NLR family, pyrin domain containing 3	Rattus norvegicus	4-9
2573510-3	1989	The iv or intracerebroventricular injection of either Il-1 alpha or Il-1 beta caused dose-related increases in plasma ACTH, epinephrine, and norepinephrine levels.	Norepinephrine	141-155	interleukin 1 alpha	Rattus norvegicus	54-64
2573510-3	1989	The iv or intracerebroventricular injection of either Il-1 alpha or Il-1 beta caused dose-related increases in plasma ACTH, epinephrine, and norepinephrine levels.	Norepinephrine	141-155	interleukin 1 beta	Rattus norvegicus	68-77
2574179-1	1989	Norepinephrine (NE), acting through the alpha 1-adrenergic receptor, modules the response of rat hepatocytes in primary culture to transforming growth factor type beta 1 (TGF beta) by increasing the amount of TGF beta required for a given degree of inhibition of epidermal growth factor (EGF)-induced DNA synthesis (Houck et al., J.	Norepinephrine	0-14	transforming growth factor, beta 1	Rattus norvegicus	171-179
2574179-1	1989	Norepinephrine (NE), acting through the alpha 1-adrenergic receptor, modules the response of rat hepatocytes in primary culture to transforming growth factor type beta 1 (TGF beta) by increasing the amount of TGF beta required for a given degree of inhibition of epidermal growth factor (EGF)-induced DNA synthesis (Houck et al., J.	Norepinephrine	0-14	transforming growth factor, beta 1	Rattus norvegicus	209-217
2632703-2	1989	In contrast to the coronary bed, vasoconstriction elicited by Ang II in the rat mesentery could in part (1/3) be explained by a release of noradrenaline from the sympathetic nerve endings.	Norepinephrine	139-152	angiotensinogen	Rattus norvegicus	62-68
2558573-2	1989	CGRP lowered diastolic blood pressure by 26% and increased the heart rate by 35% and raised plasma levels of norepinephrine, epinephrine, and dopamine and renin activity (P less than 0.01).	Norepinephrine	109-123	calcitonin related polypeptide alpha	Homo sapiens	0-4
2698922-5	1989	These experiments suggest that an endothelin-1-induced contraction is largely dependent on the presence of extracellular calcium, but a partial contraction can be induced in a calcium-free medium and this may be dependent on mobilization of intracellular calcium from a store not affected by repeated noradrenaline stimulation.	Norepinephrine	301-314	endothelin 1	Homo sapiens	34-46
2698921-4	1989	Subpressor doses of endothelin-1 (10(-11) and 10(-10) mol/l) enhanced the pressor response to noradrenaline, and 10(-12) to 10(-10) mol/l endothelin-1 attenuated the pressor response to periarterial nerve stimulation.	Norepinephrine	94-107	endothelin 1	Rattus norvegicus	20-32
2698921-5	1989	Endothelin-1 also caused a dose-dependent inhibition of [3H]-noradrenaline release during the periarterial nerve stimulation.	Norepinephrine	61-74	endothelin 1	Rattus norvegicus	0-12
2600818-1	1989	Neuropeptide Y (NPY) is colocalized with norepinephrine and coreleased from adrenergic nerves.	Norepinephrine	41-55	neuropeptide Y	Rattus norvegicus	0-14
2698922-2	1989	Endothelin-1 was 1000-fold more potent than noradrenaline, with an ED50 of 6.5 +/- 1.26 x 10(-9) mol/l compared with 2.1 +/- 0.7 x 10(-6) mol/l.	Norepinephrine	44-57	endothelin 1	Homo sapiens	0-12
2692889-8	1989	In the presence of cocaine, both angiotensin I (0.3 mumol/L) and angiotensin II (0.3 mumol/L) produced almost two-fold enhancements in the SI release of noradrenaline.	Norepinephrine	153-166	angiotensinogen	Rattus norvegicus	65-79
2692889-12	1989	Saralasin (0.1 mumol/L) reduced the facilitatory effect of angiotensin II on noradrenaline release but did not alter that of isoprenaline.	Norepinephrine	77-90	angiotensinogen	Rattus norvegicus	59-73
2600818-1	1989	Neuropeptide Y (NPY) is colocalized with norepinephrine and coreleased from adrenergic nerves.	Norepinephrine	41-55	neuropeptide Y	Rattus norvegicus	16-19
2600818-6	1989	NPY potentiated responses to longer transmural nerve stimulation trains (30-100 pulses) or to exogenous norepinephrine by only 30%.	Norepinephrine	104-118	neuropeptide Y	Rattus norvegicus	0-3
2600818-10	1989	NPY increased the rate of contraction to both norepinephrine and transmural nerve stimulation.	Norepinephrine	46-60	neuropeptide Y	Rattus norvegicus	0-3
2575997-4	1989	When combined with noradrenaline, the antagonists with intrinsic sympathomimetic activity prevented the action of noradrenaline at both beta 1- and beta 2-adrenoceptors, thereby leading to an apparent up-regulation of receptor density and response.	Norepinephrine	19-32	adrenoceptor beta 1	Rattus norvegicus	136-168
2626080-6	1989	It is suggested that the augmented release of noradrenaline (NA) resulting from alpha 2-adrenoceptor blockade decreases the exploratory behavior effects of AT II.	Norepinephrine	46-59	angiotensinogen	Rattus norvegicus	156-161
2557014-5	1989	On the other hand, the reactivity of brown fat to increase expression of UCP and COII mRNAs in response to acute cold or noradrenaline treatment is not impaired during lactation.	Norepinephrine	121-134	uncoupling protein 1	Rattus norvegicus	73-76
2560726-10	1989	Thus, high levels of norepinephrine were able to induce a decrease of both beta-adrenoceptor and insulin receptor binding, together with a marked reduction of in vitro agonist-induced redistribution of beta-adrenergic receptors.	Norepinephrine	21-35	insulin	Homo sapiens	97-104
2575997-4	1989	When combined with noradrenaline, the antagonists with intrinsic sympathomimetic activity prevented the action of noradrenaline at both beta 1- and beta 2-adrenoceptors, thereby leading to an apparent up-regulation of receptor density and response.	Norepinephrine	114-127	adrenoceptor beta 1	Rattus norvegicus	136-168
2482969-0	1989	Effects of hexachlorocyclohexane (HCH) on the contractile response induced by norepinephrine in the rat isolated vas deferens.	Norepinephrine	78-92	arginine vasopressin	Rattus norvegicus	113-116
2614337-4	1989	Dorsal aortic injections of epinephrine or norepinephrine increased plasma glucose (16-46%), had no effect on liver or muscle glycogen levels, decreased the activity of PK, and increased total and percent GPase a activities.	Norepinephrine	43-57	pyruvate kinase PKM	Oncorhynchus mykiss	169-171
2482969-1	1989	Effects of hexachlorocyclohexane (Technical HCH) on the contractile responses of rat isolated Vas deferens to norepinephrine (NE) were investigated by varying the Ca++ and Mg++ concentrations of the incubation medium.	Norepinephrine	110-124	arginine vasopressin	Rattus norvegicus	94-97
2804665-0	1989	Neuropeptide Y potentiates excitation of supraoptic neurosecretory cells by noradrenaline.	Norepinephrine	76-89	neuropeptide Y	Rattus norvegicus	0-14
2813439-3	1989	Intracerebroventricular injection of norepinephrine (2 micrograms/rat) or epinephrine (100 ng and 1 microgram/rat) caused an increase in plasma PRL levels.	Norepinephrine	37-51	prolactin	Rattus norvegicus	144-147
2478028-5	1989	Depletion of intracellular Ca2+ stores by caffeine or ryanodine also diminished cytosolic [Ca2+] responses, indicating that a portion of the increased cytosolic [Ca2+] is due to Ca2+ release from SR. Norepinephrine potentiates the ATP-Ca2+ response, and this effect was not inhibited by depletion of intracellular stores.	Norepinephrine	200-214	carbonic anhydrase 2	Rattus norvegicus	27-30
2679773-0	1989	Humoral effect of norepinephrine on renin release in humans.	Norepinephrine	18-32	renin	Homo sapiens	36-41
2478028-5	1989	Depletion of intracellular Ca2+ stores by caffeine or ryanodine also diminished cytosolic [Ca2+] responses, indicating that a portion of the increased cytosolic [Ca2+] is due to Ca2+ release from SR. Norepinephrine potentiates the ATP-Ca2+ response, and this effect was not inhibited by depletion of intracellular stores.	Norepinephrine	200-214	carbonic anhydrase 2	Rattus norvegicus	91-94
2478028-5	1989	Depletion of intracellular Ca2+ stores by caffeine or ryanodine also diminished cytosolic [Ca2+] responses, indicating that a portion of the increased cytosolic [Ca2+] is due to Ca2+ release from SR. Norepinephrine potentiates the ATP-Ca2+ response, and this effect was not inhibited by depletion of intracellular stores.	Norepinephrine	200-214	carbonic anhydrase 2	Rattus norvegicus	91-94
2478028-5	1989	Depletion of intracellular Ca2+ stores by caffeine or ryanodine also diminished cytosolic [Ca2+] responses, indicating that a portion of the increased cytosolic [Ca2+] is due to Ca2+ release from SR. Norepinephrine potentiates the ATP-Ca2+ response, and this effect was not inhibited by depletion of intracellular stores.	Norepinephrine	200-214	carbonic anhydrase 2	Rattus norvegicus	91-94
2478028-5	1989	Depletion of intracellular Ca2+ stores by caffeine or ryanodine also diminished cytosolic [Ca2+] responses, indicating that a portion of the increased cytosolic [Ca2+] is due to Ca2+ release from SR. Norepinephrine potentiates the ATP-Ca2+ response, and this effect was not inhibited by depletion of intracellular stores.	Norepinephrine	200-214	carbonic anhydrase 2	Rattus norvegicus	91-94
2575615-12	1989	A high dose of mATP, in addition, decreased the vasopressor responses to noradrenaline, methoxamine, B-HT 920 and electrical stimulation; the delayed effects of ATP on blood pressure were not changed.	Norepinephrine	73-86	solute carrier family 45, member 2	Mus musculus	15-19
2801921-5	1989	Incubation of neuronal cultures with norepinephrine (NE) at concentrations (greater than 5 microM) and for times (15-60 min) that cause large increases in IP hydrolysis caused increases in the number of ANG II-specific binding sites, mimicking the actions of phorbol esters.	Norepinephrine	37-51	angiotensinogen	Rattus norvegicus	203-209
2679151-1	1989	The role of renal nerves and norepinephrine release on renin secretion during fetal and postnatal maturation has not been studied.	Norepinephrine	29-43	renin	Ovis aries	55-60
2679151-7	1989	These results suggest that 1) norepinephrine released from nerve terminals may regulate active renin secretion early during development; 2) the effect of veratridine on active renin secretion was similar in fetal, newborn, and adult sheep; 3) veratridine had no significant effect on inactive renin secretion; and 4) active renin secretion due to depolarization of nerve terminals in fetal sheep is dependent on activation of beta-adrenoceptors as it is in adults.	Norepinephrine	30-44	renin	Ovis aries	95-100
2550484-5	1989	Pretreatment with tumor necrosis factor synergistically enhanced prostaglandin synthesis in response to bradykinin, bombesin, thrombin, norepinephrine, and platelet-activating factor.	Norepinephrine	136-150	tumor necrosis factor	Homo sapiens	18-39
2684314-12	1989	Submaximal concentrations of ET-1 (3 nM), [Ala3,11]ET-1 (75 nM) and [Ala1,15]ET-1 (0.41 microM), gave about 85% of maximal contractions elicited by noradrenaline (1 microM) in normal, calcium-containing medium.	Norepinephrine	148-161	endothelin 1	Rattus norvegicus	29-33
2809479-2	1989	In this study, noradrenaline (0.1 nmol-0.1 mumol/l) stimulated the release of both immunoreactive corticotrophin-releasing factor-41 (ir-CRF-41) and ir-arginine vasopressin (ir-AVP) from the rat hypothalamus in vitro.	Norepinephrine	15-28	arginine vasopressin	Rattus norvegicus	161-172
2685117-3	1989	We found that during mild LBNP systemic blood pressure was maintained after acute and chronic ACE inhibition, as in control studies; however, the decrements in forearm blood flow and the increments in forearm vascular resistance caused by LBNP were diminished after ACE inhibition (the latter by 69 and 67%, respectively, in acute and chronic studies), in spite of the fact that the falls in central venous pressure and the increases in noradrenaline (NA) were similar to those observed in control conditions.	Norepinephrine	437-450	angiotensin I converting enzyme	Homo sapiens	266-269
2570793-2	1989	Norepinephrine (NE)-producing neurons are identified by immunocytochemistry of two NE biosynthetic enzymes, tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH), visualized by the peroxidase-antiperoxidase and immunogold-silver-staining methods.	Norepinephrine	0-14	tyrosine hydroxylase	Homo sapiens	108-128
2553199-7	1989	These results suggest that the pressor response produced by microinjection of noradrenaline into the hypothalamic PVN of conscious Long-Evans rats is mediated largely through stimulation of alpha 2-adrenoceptors and is dependent, in part, on release of AVP into the circulation.	Norepinephrine	78-91	arginine vasopressin	Rattus norvegicus	253-256
2768812-0	1989	Acute action of DSP-4 on central norepinephrine axons: biochemical and immunohistochemical evidence for differential effects.	Norepinephrine	33-47	dual specificity phosphatase 26	Homo sapiens	16-21
2768812-1	1989	Previous immunohistochemical studies of the long-term effects of the noradrenergic neurotoxin DSP-4 have demonstrated a remarkably selective vulnerability of norepinephrine (NE) axons of the locus coeruleus (LC).	Norepinephrine	158-172	dual specificity phosphatase 26	Homo sapiens	94-99
2529058-9	1989	Direct correlations between the percent changes in forearm vascular resistance and those in plasma norepinephrine and plasma renin activity were found only in normal subjects in control conditions but were not observed after sympathetic blockade.	Norepinephrine	99-113	renin	Homo sapiens	125-130
2752979-11	1989	In isolated helical strips of rat aorta, PTHrp and PTH relaxed norepinephrine-contracted tissues in a concentration-dependent fashion.	Norepinephrine	63-77	parathyroid hormone	Rattus norvegicus	41-44
2576679-5	1989	Here, VIP provokes the excitation, vasodilatation and together with noradrenaline participates in the regulation of cortical energy metabolism.	Norepinephrine	68-81	vasoactive intestinal peptide	Homo sapiens	6-9
2667643-2	1989	After primary culture for 5 days in the presence of glucose, the lipogenic response to insulin increased, the glucagon response decreased and noradrenaline produced the same degree of inhibition at 3 h. At 24 h, insulin produced an even higher increase on lipogenesis parallel to an increase in fatty acid synthase activity.	Norepinephrine	142-155	insulin	Homo sapiens	212-219
2804310-0	1989	[Effects of neuropeptide Y on behavior and noradrenaline level in the brain].	Norepinephrine	43-56	neuropeptide Y	Rattus norvegicus	12-26
2673239-2	1989	Conversely, noradrenaline prevented the induction caused by insulin on enzyme expression through an accelerate rate of malic enzyme degradation.	Norepinephrine	12-25	insulin	Homo sapiens	60-67
2546435-7	1989	Norepinephrine inhibits VIP-stimulated changes in Isc as well as the basal Isc.	Norepinephrine	0-14	vasoactive intestinal peptide	Homo sapiens	24-27
2547494-13	1989	GDP beta S reduced noradrenaline outward current but not caffeine outward current implying the existence of a G-protein step in noradrenaline-evoked Ca-store release, possibly regulating phospholipase C enzyme activity and D-myo inositol 1,4,5 trisphosphate formation.	Norepinephrine	128-141	LOC100009319	Oryctolagus cuniculus	187-202
2472359-0	1989	Neuropeptide Y and galanin in norepinephrine release in hypothalamic slices.	Norepinephrine	30-44	neuropeptide Y	Rattus norvegicus	0-14
2472359-4	1989	The inhibition of norepinephrine release by the alpha-2 agonist UK 14,304 was potentiated by neuropeptide Y and galanin.	Norepinephrine	18-32	neuropeptide Y	Rattus norvegicus	93-107
2472359-5	1989	The blockade of the alpha 2-adrenergic receptors by RX 781094 diminished the inhibitory effects of neuropeptide Y and galanin on norepinephrine release.	Norepinephrine	129-143	neuropeptide Y	Rattus norvegicus	99-113
2472359-6	1989	Pretreatment of hypothalamic slices with islet activating protein (a toxin that interferes with the coupling of inhibitory receptors to adenylate cyclase) attenuated the suppression of norepinephrine release by UK 14,304, neuropeptide Y, and galanin.	Norepinephrine	185-199	neuropeptide Y	Rattus norvegicus	222-236
2757892-9	1989	Glyceryl trinitrate (0.4 microgram min-1) however, completely reversed the constriction to noradrenaline (P less than 0.001).	Norepinephrine	91-104	CD59 molecule (CD59 blood group)	Homo sapiens	35-40
2797213-1	1989	Microdialysis was used to investigate whether angiotensin II modulates the basal and K+-induced release of endogenous noradrenaline, dopamine and their metabolites 3,4-dihydroxyphenylglycol (DOPEG) and 3,4-dihydroxyphenylacetic acid (DOPAC) from the anterior hypothalamus of the anaesthetized rat.	Norepinephrine	118-131	angiotensinogen	Rattus norvegicus	46-60
2477116-2	1989	Following the administration of 100 pmoles of NPY into the ventromedial hypothalamus of conscious rats, there was a significant reduction in the local concentration of norepinephrine and an even greater reduction in the concentration of its metabolite, MHPG, as compared to saline-injected controls.	Norepinephrine	168-182	neuropeptide Y	Rattus norvegicus	46-49
2477116-4	1989	When NPY was injected into the lateral hypothalamus and monoamines measured from areas adjacent to the injection of NPY there was a significant increase in norepinephrine release and a significant increase in the concentration of DOPAC.	Norepinephrine	156-170	neuropeptide Y	Rattus norvegicus	5-8
2477116-4	1989	When NPY was injected into the lateral hypothalamus and monoamines measured from areas adjacent to the injection of NPY there was a significant increase in norepinephrine release and a significant increase in the concentration of DOPAC.	Norepinephrine	156-170	neuropeptide Y	Rattus norvegicus	116-119
2503223-4	1989	Noradrenaline concentrations measured in heart ventricle, terminal ileum, vas deferens, spleen and adrenal tissue from the diabetic rats were all found to be elevated compared to those found in control rat tissues.	Norepinephrine	0-13	arginine vasopressin	Rattus norvegicus	74-77
2503223-7	1989	Noradrenaline turnover in heart ventricle, terminal ileum and vas deferens was estimated from the decline in tissue content of the amine following inhibition of its synthesis with alpha-methyl-p-tyrosine.	Norepinephrine	0-13	arginine vasopressin	Rattus norvegicus	62-65
2758328-1	1989	Long-term potentiation (LTP) in the CA3 hippocampal subfield, elicited in vivo, produced significant increases in basal and in carbachol- and noradrenaline-induced hydrolysis of phosphatidylinositol-4,5-biphosphate (PtdIns(4,5)P2) as measured by the accumulation of InsP1 in hippocampal slices in vitro.	Norepinephrine	142-155	carbonic anhydrase 3	Homo sapiens	36-39
2736879-2	1989	Endogenous noradrenaline release from washed platelets incubated under resting conditions and in the presence of thrombin was examined in 14 normal subjects and 10 subjects with type 1 (insulin-dependent) diabetes.	Norepinephrine	11-24	coagulation factor II, thrombin	Homo sapiens	113-121
2757896-12	1989	Angiotensin II when infused with placebo caused a 37% fall in absolute sodium excretion and a 32% fall when infused with noradrenaline (no significant difference between the 2 days).	Norepinephrine	121-134	angiotensinogen	Homo sapiens	0-14
2736879-7	1989	Stimulation with thrombin (0.3 unit/ml) elicited marked platelet release of noradrenaline to the incubation medium in both normal and diabetic subjects.	Norepinephrine	76-89	coagulation factor II, thrombin	Homo sapiens	17-25
2736879-8	1989	Supernatant noradrenaline concentrations obtained under thrombin-stimulated conditions did not significantly differ between normal and diabetic subjects.	Norepinephrine	12-25	coagulation factor II, thrombin	Homo sapiens	56-64
2497110-2	1989	In particular, changes that occur in sympathetic nerve content of the vasoconstrictor agents serotonin (5-HT) and neuropeptide Y (NPY), which are colocalized with noradrenaline, were assessed.	Norepinephrine	163-176	neuropeptide Y	Rattus norvegicus	130-133
2572419-1	1989	The stimulant effects of adrenaline and noradrenaline on contractile force and adenylate cyclase, mediated through beta 1 and beta 2-adrenoceptors, are analysed in isolated atrial and ventricular myocardium of man.	Norepinephrine	40-53	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	115-121
2776081-6	1989	Measurement of catecholamine concentration of the supernatant from homogenates used for the Ang II binding assay revealed a significant correlation between the specific binding of Ang II to brain membranes of the two tryptophan-treated groups and the concentration of norepinephrine in the supernatant.	Norepinephrine	268-282	angiotensinogen	Rattus norvegicus	92-98
2776081-6	1989	Measurement of catecholamine concentration of the supernatant from homogenates used for the Ang II binding assay revealed a significant correlation between the specific binding of Ang II to brain membranes of the two tryptophan-treated groups and the concentration of norepinephrine in the supernatant.	Norepinephrine	268-282	angiotensinogen	Rattus norvegicus	180-186
2509210-1	1989	We have examined resting and thrombin (0.3 units ml-1) induced release of noradrenaline by washed platelets from 15 normal subjects and eight patients with heterozygous familial hypercholesterolaemia.	Norepinephrine	74-87	coagulation factor II, thrombin	Homo sapiens	29-37
2509210-5	1989	Thrombin-stimulated release of noradrenaline was also higher (73%, P less than 0.05) in hypercholesterolaemics than in normals.	Norepinephrine	31-44	coagulation factor II, thrombin	Homo sapiens	0-8
2509210-8	1989	However, following thrombin stimulation total noradrenaline concentrations were substantially greater (86%) in platelets from hypercholesterolaemics than normals (P less than 0.02).	Norepinephrine	46-59	coagulation factor II, thrombin	Homo sapiens	19-27
2509210-9	1989	In hypercholesterolaemic patients thrombin stimulation was associated with an 101% increase (over resting levels) in total platelet noradrenaline (P less than 0.01), no increases being observed with normal subjects.	Norepinephrine	132-145	coagulation factor II, thrombin	Homo sapiens	34-42
2773665-7	1989	Infusion of nitroprusside at a dose lowering the mean blood pressure by 11.6 +/- 1.6 mmHg and increasing the heart rate to 74.6 +/- 2.9 beats min-1 elevated plasma noradrenaline to 2.86 +/- 0.39 nM.	Norepinephrine	164-177	CD59 molecule (CD59 blood group)	Homo sapiens	142-147
2528578-7	1989	Plasma renin activity (PRA) was assessed by radio-immunoassay of generated angiotensin I and arterial noradrenaline concentrations using high-performance liquid chromatography (HPLC).	Norepinephrine	102-115	renin	Homo sapiens	7-12
2543391-0	1989	Evidence for a peroxidatic oxidation of norepinephrine, a catecholamine, by lactoperoxidase.	Norepinephrine	40-54	lactoperoxidase	Homo sapiens	76-91
2543391-1	1989	The electron spin resonance-spin stabilization technique has been applied to identify the o-semiquinone intermediate produced during the lactoperoxidase-catalyzed oxidation of the catecholamine norepinephrine.	Norepinephrine	194-208	lactoperoxidase	Homo sapiens	137-152
2673114-1	1989	The hypothesis that facilitation of noradrenaline release by prejunctional beta-adrenoceptors is linked to the local generation of angiotensin II was investigated in rat tail artery and mouse atria which were incubated with [3H]-noradrenaline.	Norepinephrine	36-49	angiotensinogen	Rattus norvegicus	131-145
2673114-3	1989	In mouse atria, angiotensin II (0.01 microM) enhanced the stimulation-induced (S-I) noradrenaline release and this was blocked by saralasin (0.1 microM).	Norepinephrine	84-97	angiotensinogen	Rattus norvegicus	16-30
2673114-6	1989	In rat tail artery, the facilitatory effect of angiotensin II (0.01 microM) on noradrenaline release was blocked by saralasin (0.1 microM).	Norepinephrine	79-92	angiotensinogen	Rattus norvegicus	47-61
2774766-2	1989	The contractions of the rat Vas deferens elicited by noradrenaline and phenylephrine were inhibited by vitamin K3, noncompetitively.	Norepinephrine	53-66	arginine vasopressin	Rattus norvegicus	28-31
2570094-2	1989	Noradrenaline significantly inhibited plasma insulin levels but did not change plasma glucagon and somatostatin concentrations.	Norepinephrine	0-13	insulin	Homo sapiens	45-52
2773665-9	1989	Infusion of nitroprusside at a rate lowering the blood pressure by 11.2 +/- 2.4 mmHg and increasing the heart rate to 74.4 +/- 0.5 beats min-1, elevated the plasma level of noradrenaline to 2.46 +/- 0.38 ng ml-1, which is not different from before ibuprofen.	Norepinephrine	173-186	CD59 molecule (CD59 blood group)	Homo sapiens	137-142
2571139-2	1989	Following priming with 2.5 micrograms NPY, or larger doses, the subsequent administrations of noradrenaline produced pressor responses that were potentiated both in magnitude and duration.	Norepinephrine	94-107	neuropeptide Y	Rattus norvegicus	38-41
2526114-9	1989	The association of higher plasma ANP and blunted plasma vasopressin, plasma renin activity, and norepinephrine concentrations during supine exercise suggests that ANP may exert modulatory effects on the control of the hydromineral hormonal system during exercise.	Norepinephrine	96-110	natriuretic peptide A	Homo sapiens	33-36
2526114-9	1989	The association of higher plasma ANP and blunted plasma vasopressin, plasma renin activity, and norepinephrine concentrations during supine exercise suggests that ANP may exert modulatory effects on the control of the hydromineral hormonal system during exercise.	Norepinephrine	96-110	natriuretic peptide A	Homo sapiens	163-166
2542698-8	1989	Similarly, exposure of the slice to norepinephrine (e.g. 20 microM for 30 min) results in a long-lasting potentiation (LLP) of both EPSP and population spike (Stanton and Sarvey (1987) Brain Res.	Norepinephrine	36-50	LLP homolog, long-term synaptic facilitation factor	Homo sapiens	119-122
2539971-10	1989	Norepinephrine and epinephrine similarly inhibited POMC peptide secretion, but this effect was blocked by haloperidol, suggesting that it was mediated through a dopamine receptor.	Norepinephrine	0-14	proopiomelanocortin	Canis lupus familiaris	51-55
2524228-3	1989	In the cerebral and pancreatic arteries atriopeptin stops norepinephrine-induced contractions.	Norepinephrine	58-72	natriuretic peptide A	Homo sapiens	40-51
2571139-3	1989	The NPY-induced potentiation of the pressor response to noradrenaline was dose-dependent and extended to the pressor action of adrenaline and angiotensin II but not to the hypotensions produced by bradykinin or isoproterenol.	Norepinephrine	56-69	neuropeptide Y	Rattus norvegicus	4-7
2571139-3	1989	The NPY-induced potentiation of the pressor response to noradrenaline was dose-dependent and extended to the pressor action of adrenaline and angiotensin II but not to the hypotensions produced by bradykinin or isoproterenol.	Norepinephrine	56-69	angiotensinogen	Rattus norvegicus	142-156
2724692-1	1989	In the HEPES-buffered physiological solution containing 20 mM bicarbonate ion, cocaine not only increased the sensitivity to norepinephrine but enhanced the maximal contractions to norepinephrine and methacholine in the rat vas deferens.	Norepinephrine	181-195	arginine vasopressin	Rattus norvegicus	224-227
2702737-2	1989	Angiotensin I (10 microM), angiotensin II (0.1 microM), and norepinephrine (10 microM) increased perfusion pressure, and norepinephrine, but not angiotensin I or II, contracted afferent arterioles, indicating that the vessels are reactive.	Norepinephrine	121-135	angiotensinogen	Rattus norvegicus	27-41
2547952-10	1989	In conclusion, this low infusion rate of ANF produced similar changes in plasma ANF, cGMP, aldosterone and noradrenaline levels but patients with mild essential hypertension demonstrated an exaggerated diuretic and natriuretic response to ANF infusion.	Norepinephrine	107-120	natriuretic peptide A	Homo sapiens	41-44
2498609-0	1989	Effect of insulin on plasma norepinephrine and 3,4-dihydroxyphenylalanine in obese men.	Norepinephrine	28-42	insulin	Homo sapiens	10-17
2521973-4	1989	The plasma ANP level in the mPA correlated with the plasma norepinephrine level in the Ao (r = 0.71, p less than 0.01), right atrial pressure (r = 0.34, p less than 0.05), mean pulmonary capillary wedge pressure (r = 0.829, p less than 0.001), and left ventricular end-diastolic pressure (LVEDP) (r = 0.88, p less than 0.001).	Norepinephrine	59-73	natriuretic peptide A	Homo sapiens	11-14
2744081-1	1989	The study concerned Ca2+ channels that are receptor-operated by norepinephrine (NE) and mediate hyper-reactivity of vas deferens smooth muscle from rats with streptozotocin (STZ)-induced diabetes, and the mediatory responses of these channels, such as tension development, Ca2+ uptake and phosphatidylinositol (PI) turnover.	Norepinephrine	64-78	arginine vasopressin	Rattus norvegicus	116-119
19210461-0	1989	Corticotrophin-Releasing Factor Antagonist [alpha helical CRF(9-41)] Blocks Central Noradrenaline-lnduced ACTH Secretion.	Norepinephrine	84-97	proopiomelanocortin	Homo sapiens	106-110
19210461-1	1989	Plasma ACTH increased after an intra-third ventricular administration of noradrenaline (NA).	Norepinephrine	73-86	proopiomelanocortin	Homo sapiens	7-11
2537795-6	1989	The combination of ANF plus captopril produced a significant increase in plasma aldosterone (79 +/- 8 vs. 60 +/- 6 pmol/l, p less than 0.05), cortisol (406 +/- 52 vs. 265 +/- 29 nmol/l, p less than 0.01), adrenaline (119 +/- 21 vs. 76 +/- 10 pg/ml, p less than 0.05), and noradrenaline (319 +/- 49 vs. 215 +/- 38 pg/ml, p less than 0.05) compared with time-matched placebo data.	Norepinephrine	272-285	natriuretic peptide A	Homo sapiens	19-22
2795490-16	1989	ACh and histamine relaxed the tissues from SPA, MPA and aorta during the noradrenaline (NA)- or high [K+]o solution-induced contraction, in a concentration-dependent manner, only when the endothelial cells were intact.	Norepinephrine	73-86	surfactant protein A1	Rattus norvegicus	43-46
2539427-6	1989	The platelet noradrenaline efflux rate tended to be higher in patients with lower brake indices, a sign of autonomic neuropathy, than in controls (29.0 +/- 3.0 x 10(-3) min-1 vs. 21.2 +/- 0.9 x 10(-3) min-1; P less than 0.05).	Norepinephrine	13-26	CD59 molecule (CD59 blood group)	Homo sapiens	169-174
2539427-6	1989	The platelet noradrenaline efflux rate tended to be higher in patients with lower brake indices, a sign of autonomic neuropathy, than in controls (29.0 +/- 3.0 x 10(-3) min-1 vs. 21.2 +/- 0.9 x 10(-3) min-1; P less than 0.05).	Norepinephrine	13-26	CD59 molecule (CD59 blood group)	Homo sapiens	201-206
2564694-7	1989	Noradrenaline (100-1000 pmol kg-1 min-1 intravenously) increased rectal tone and anal canal pressure.	Norepinephrine	0-13	CD59 molecule (CD59 blood group)	Homo sapiens	34-39
2496890-0	1989	Decreased norepinephrine in the ventral lamina terminalis region is associated with angiotensin II drinking response deficits following local 6-hydroxydopamine injections.	Norepinephrine	10-24	angiotensinogen	Rattus norvegicus	84-98
2548506-2	1989	Simultaneous injection of arginine vasopressin with luteinizing hormone, norepinephrine or cholera toxin inhibited these agonists - induced testosterone response.	Norepinephrine	73-87	arginine vasopressin	Rattus norvegicus	35-46
2567554-3	1989	The secretion of growth hormone is controlled by hypothalamic hormones, somatotropin releasing factor and somatotropin release-inhibiting factor; of the neurotransmitters, the strongest effects have noradrenaline and dopamine.	Norepinephrine	199-212	growth hormone 1	Homo sapiens	17-31
2567554-4	1989	The release of ACTH is controlled by two stimulating hormones, the ACTH releasing factor and vasopressin, the effects of neurotransmitters are less marked, with the involvement of noradrenaline, serotonin, acetylcholine, gamma aminobutyric acid and other agents.	Norepinephrine	180-193	proopiomelanocortin	Homo sapiens	15-19
2645906-7	1989	On one hand, if injected in pharmacological doses, it is a vasodilator and antagonizes the pressor action of norepinephrine and angiotensin II; on the other hand, parathyroid hormone can potentiate the pressor effect of hypercalcemia.	Norepinephrine	109-123	parathyroid hormone	Homo sapiens	163-182
2564430-1	1989	This study explored an effector mechanism associated with the arginine vasopressin (AVP) recognition site in the hippocampus, namely, potentiation of norepinephrine (NE)-induced cAMP accumulation in the surviving hippocampal slice.	Norepinephrine	150-164	arginine vasopressin	Rattus norvegicus	71-82
2492517-4	1989	Superoxide dismutase and catalase inhibited partially the noradrenaline-dependent activation of the enzyme.	Norepinephrine	58-71	catalase	Rattus norvegicus	25-33
2548506-4	1989	However, testosterone response to luteinizing hormone, norepinephrine or cholera toxin was drastically reduced in arginine vasopressin-desensitized testis.	Norepinephrine	55-69	arginine vasopressin	Rattus norvegicus	123-134
2548506-5	1989	This shows that the increased cAMP generated by luteinizing hormone, norepinephrine or cholera toxin in arginine vasopressin desensitized testis did not cause increase in steroidogenesis.	Norepinephrine	69-83	arginine vasopressin	Rattus norvegicus	113-124
2521270-5	1989	The plasma ANF level was directly correlated with the plasma norepinephrine concentration (r = 0.83, p less than 0.01), plasma epinephrine concentration (r = 0.46, p less than 0.01), plasma renin activity (r = 0.50, p less than 0.01), plasma angiotensin II concentration (r = 0.79, p less than 0.01) and plasma vasopressin concentrations (r = 0.65, p less than 0.01).	Norepinephrine	61-75	natriuretic peptide A	Homo sapiens	11-14
2493961-10	1989	Pretreatment with 6-hydroxydopamine resulted in an enhanced pressor response to 1 microgram kg-1 noradrenaline in both Brattleboro and Long Evans rats, but the effect was significantly greater in the vasopressin-deficient animals.	Norepinephrine	97-110	arginine vasopressin	Rattus norvegicus	200-211
2670220-3	1989	ACE inhibitors reduce circulating levels of angiotensin II and aldosterone and may reduce plasma norepinephrine and vasopressin levels.	Norepinephrine	97-111	angiotensin I converting enzyme	Homo sapiens	0-3
2690910-8	1989	In addition, converting enzyme inhibitors may directly (by a prejunctional effect) and indirectly (by curtailing the production of angiotensin II) reduce the release of noradrenaline in the blood vessel wall.	Norepinephrine	169-182	angiotensinogen	Homo sapiens	131-145
2909302-2	1989	Neuropeptide Y (NPY) coexists with adrenaline and noradrenaline in the rat brain, and interactions among these substances have been studied.	Norepinephrine	50-63	neuropeptide Y	Rattus norvegicus	0-14
2572385-6	1989	Increases in the peripheral levels of PRL in these animals were associated with decreases in adrenal medulla weight and increases in adrenal medulla contents of norepinephrine, epinephrine and vanilmandelic acid, the main degradative metabolite of CA, while adrenal medulla contents of the O-methylated derivatives of CA, normetanephrine and metanephrine, were unaltered.	Norepinephrine	161-175	prolactin	Mesocricetus auratus	38-41
2927024-5	1989	NT (0.1 and 1 microgram/ml), like norepinephrine, decreased the flow rate of perfusate from the isolated rectum which was perfused at a constant pressure.	Norepinephrine	34-48	neurotensin	Gallus gallus	0-2
2924078-0	1989	Release of 5-hydroxytryptamine, dopamine and noradrenaline in the rat vas deferens in the presence of compound 48/80, veratridine or K+.	Norepinephrine	45-58	arginine vasopressin	Rattus norvegicus	70-73
2483232-6	1989	Special attention is paid to the possible effects of angiotensin converting enzyme inhibitors in this situation, as this group of agents combine several interesting characteristics of other groups, among which are their effects on norepinephrine levels, prostaglandin synthesis, and free radicals.	Norepinephrine	231-245	angiotensin I converting enzyme	Homo sapiens	53-82
2565274-8	1989	Since pineal gland uptake of radiolabelled norepinephrine (NE) was impaired by xylamine, the drug may increase pineal gland NAT activity by inhibiting NE reuptake into the presynaptic nerve terminal, thereby increasing the amount of the neurotransmitter available to stimulate pinealocyte beta-noradrenoceptors.	Norepinephrine	43-57	N-acetyltransferase 1	Rattus norvegicus	124-127
2656466-4	1989	On the other hand, there is considerable evidence that brain AII stimulates the secretion of luteinizing hormone (LH) by increasing the secretion of LH-releasing hormone, and that this effect is due to AII-mediated release of norepinephrine from noradrenergic nerve terminals in the preoptic region of the hypothalamus.	Norepinephrine	226-240	angiotensinogen	Rattus norvegicus	61-64
2656466-4	1989	On the other hand, there is considerable evidence that brain AII stimulates the secretion of luteinizing hormone (LH) by increasing the secretion of LH-releasing hormone, and that this effect is due to AII-mediated release of norepinephrine from noradrenergic nerve terminals in the preoptic region of the hypothalamus.	Norepinephrine	226-240	angiotensinogen	Rattus norvegicus	202-205
2468921-8	1989	In human ventricular membranes xamoterol stimulated marginally the adenylate cyclase and antagonized the effects of (-)-norepinephrine with a 30-fold greater affinity for beta 1- than for beta 2-adrenoceptors.	Norepinephrine	116-134	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	171-177
3067127-3	1988	injection of chicken GnRH II or salmon GnRH increased plasma noradrenaline and adrenaline concentrations, at doses that did not significantly affect arterial blood pressure or heart rate.	Norepinephrine	61-74	mitochondrial ribosomal protein S26	Gallus gallus	21-28
2473353-0	1989	Effects of norepinephrine and angiotensin II on plasma atrial natriuretic peptide concentration in humans.	Norepinephrine	11-25	natriuretic peptide A	Homo sapiens	55-81
2473353-2	1989	When norepinephrine infusion elevated mean arterial pressure by 15 mm Hg, a transient increase of plasma ANP was observed.	Norepinephrine	5-19	natriuretic peptide A	Homo sapiens	105-108
2473353-6	1989	From these results, it was concluded that increased left atrial volume due to increased venous return is the major factor inducing ANP release in norepinephrine infusion.	Norepinephrine	146-160	natriuretic peptide A	Homo sapiens	131-134
2473356-4	1989	ANP-induced vasodilation can easily be overcome by norepinephrine and to a lesser extent by angiotension II (Ang II).	Norepinephrine	51-65	natriuretic peptide A	Homo sapiens	0-3
2922111-6	1989	After inhibition of noradrenaline reuptake by desipramine the vasoconstrictor response and noradrenaline output were enhanced while the corresponding overflow of neuropeptide Y was reduced by 50% at 0.5 Hz.	Norepinephrine	20-33	neuropeptide Y	Sus scrofa	162-176
2571183-5	1989	The stimulatory influence of norepinephrine, serotonin, and acetylcholine on the secretion of corticotropin (ACTH) in rodents and man will be discussed, whereas GABA exerts an inhibitory effect on the secretion of ACTH in both man and rodents.	Norepinephrine	29-43	proopiomelanocortin	Homo sapiens	109-113
2480485-6	1989	In these patients, norepinephrine was enhanced by a factor of 7, epinephrine by a factor of 2, plasma renin activity by a factor of 7, angiotensin II by a factor of 2.5, aldosterone by a factor of 5, vasopressin by a factor of 1.5, and ANF by a factor of 4 compared with those in normal subjects.	Norepinephrine	19-33	arginine vasopressin	Homo sapiens	200-211
2480485-6	1989	In these patients, norepinephrine was enhanced by a factor of 7, epinephrine by a factor of 2, plasma renin activity by a factor of 7, angiotensin II by a factor of 2.5, aldosterone by a factor of 5, vasopressin by a factor of 1.5, and ANF by a factor of 4 compared with those in normal subjects.	Norepinephrine	19-33	natriuretic peptide A	Homo sapiens	236-239
2542808-6	1989	For 3/4 of the receptors (beta 1) the affinity of (-)-noradrenaline was 20 times higher than for the remaining 1/4 (beta 2).	Norepinephrine	50-67	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	26-32
2542808-11	1989	Increases in contractile force by (-)-noradrenaline were closely associated with small increases of cyclase activity through beta 1-adrenoceptors, consistent with a common link.	Norepinephrine	34-51	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	125-131
2542808-20	1989	The more efficient activation of contractile force by (-)-noradrenaline in cat, compared to man, appears to be related to a 2-fold higher density of beta 1-adrenoceptors, a 6-fold higher production of cyclic AMP per beta 1-adrenoceptor and possibly to a more effective use of cyclic AMP for contraction.	Norepinephrine	54-71	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	149-155
3224284-0	1988	Neuropeptide Y, epinephrine and norepinephrine in the paraventricular nucleus: stimulation of feeding and the release of corticosterone, vasopressin and glucose.	Norepinephrine	32-46	arginine vasopressin	Rattus norvegicus	137-148
3192531-0	1988	Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis.	Norepinephrine	27-41	uncoupling protein 1	Rattus norvegicus	57-75
3266556-4	1988	When noradrenaline (10(-5) M) was used as the vasoconstrictor in preparations perfused with Krebs solution at constant flow, human alpha-CGRP was 10 times more potent than sodium nitroprusside in evoking dose-dependent falls in perfusion pressure.	Norepinephrine	5-18	calcitonin related polypeptide alpha	Homo sapiens	137-141
3266556-6	1988	Human alpha-CGRP and sodium nitroprusside were about equipotent at relaxing rings of superior mesenteric artery contracted by noradrenaline (10(-6) M).	Norepinephrine	126-139	calcitonin related polypeptide alpha	Homo sapiens	12-16
2850915-7	1988	In congenital HGH and ACTH deficiency, the low basal plasma levels of noradrenaline (0.12 ng/ml) and adrenaline (0.01 ng/ml) remained unchanged in response to hypoglycaemia.	Norepinephrine	70-83	proopiomelanocortin	Homo sapiens	22-26
2853744-1	1988	The relationship between changes in the pressor response to infused noradrenaline induced by intravenous injection of ouabain, an Na+,K+-ATPase inhibitor, and plasma renin activity and plasma ionized calcium was examined in 16 normotensive subjects and in 16 patients with essential hypertension.	Norepinephrine	68-81	renin	Homo sapiens	166-171
2853744-7	1988	The changes in the pressor response to noradrenaline induced by the injection of ouabain was significantly smaller in essential hypertensives, particularly in low-renin hypertensives, compared with normotensives.	Norepinephrine	39-52	renin	Homo sapiens	163-168
2906696-7	1988	Thus, stimulation of this receptor reduces noradrenaline overflow, and hence diminishes beta-adrenoceptor mediated increases in renin.	Norepinephrine	43-56	renin	Homo sapiens	128-133
3149290-3	1988	In vitro l-DOPS may serve as a substrate for aromatic-l-amino-acid decarboxylase (ALAAD) to form physiological (-)-noradrenaline.	Norepinephrine	111-128	dopa decarboxylase	Homo sapiens	45-80
3071599-0	1988	Norepinephrine and calcium responses to altered sodium intake in modulating and non-modulating high-renin hypertension.	Norepinephrine	0-14	renin	Homo sapiens	100-105
2976625-8	1988	Plasma renin activity and noradrenaline level correlated positively with plasma hANP levels.	Norepinephrine	26-39	natriuretic peptide A	Homo sapiens	80-84
3241276-2	1988	In the pithed rat the increase in diastolic blood pressure elicited by Ang II consisted of an interaction with the sympathetic nervous system involving presynaptically released noradrenaline and of a direct stimulation of postsynaptic Ang II-receptors on vascular smooth muscle.	Norepinephrine	177-190	angiotensinogen	Rattus norvegicus	71-77
3241222-2	1988	In the present study plasma concentrations of the opioid peptide beta-endorphin were significantly lower at rest in young subjects with essential hypertension and high plasma noradrenaline (n = 9) than in normotensive controls (n = 13, P less than 0.05).	Norepinephrine	175-188	proopiomelanocortin	Homo sapiens	65-79
2852216-5	1988	Simultaneous addition of VIP or secretin to the Schwann cell culture synergistically enhanced the norepinephrine-induced elevation of intracellular cyclic AMP.	Norepinephrine	98-112	vasoactive intestinal peptide	Rattus norvegicus	25-28
2973214-9	1988	The change in plasma ANF was quite variable among individual patients and was correlated with changes in  mean right atrial pressure but poorly correlated with changes in mean arterial pressure, plasma norepinephrine, and atrial cycle length.	Norepinephrine	202-216	natriuretic peptide A	Homo sapiens	21-24
2853160-4	1988	However, the further addition of a Ca2+-mobilizing hormone, such as noradrenaline or angiotensin II, together with glucagon to the perfusion medium containing 1 mM acetate caused accumulation of pyrophosphate to a similar level to that observed in vivo.	Norepinephrine	68-81	carbonic anhydrase 2	Rattus norvegicus	35-38
2459120-9	1988	Addition of increasing concentrations (1-100 microM) of the phosphodiesterase inhibitor methylisobutylxanthine (MIX) to norepinephrine (0.1 microgram/ml) gradually abolished insulin"s antagonism.	Norepinephrine	120-134	insulin	Homo sapiens	174-181
3237319-3	1988	Noradrenaline increased the concentration of OXT, but not that of AVP.	Norepinephrine	0-13	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	45-48
3254763-4	1988	Five doses of noradrenaline, 0-54 ng min-1 kg-1, were infused intravenously in random order and single-blind for 15 min per dose.	Norepinephrine	14-27	CD59 molecule (CD59 blood group)	Homo sapiens	37-47
2851354-0	1988	Contribution of beta 1- and beta 2-adrenoceptors of human atrium and ventricle to the effects of noradrenaline and adrenaline as assessed with (-)-atenolol.	Norepinephrine	97-110	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	16-22
2901339-0	1988	Norepinephrine is a possible neurotransmitter stimulating pulsatile release of luteinizing hormone-releasing hormone in the rhesus monkey.	Norepinephrine	0-14	gonadotropin releasing hormone 1	Macaca mulatta	79-116
2901339-1	1988	The hypothesis that norepinephrine (NE) plays a facilitatory role in controlling the pulsatile release of LHRH was tested with a modified push-pull perfusion technique in conscious rhesus monkeys.	Norepinephrine	20-34	gonadotropin releasing hormone 1	Macaca mulatta	106-110
2851354-16	1988	beta 1-Adrenoceptors mediate the maximum positive inotropic effects of (-)-noradrenaline in both the atrium and ventricle of man.	Norepinephrine	71-88	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	0-6
2972150-4	1988	ANP administration produced a reduction in mean arterial blood pressure accompanied by an elevation of norepinephrine and of plasma renin activity (from 2.49 +/- 0.52 to 3.39 +/- 0.85 nmol.1-1.h-1 predialysis and from 2.78 +/- 0.71 to 3.15 +/- 0.86 nmol.l-1.h-1 postdialysis, respectively, mean +/- SEM; P less than 0.05).	Norepinephrine	103-117	natriuretic peptide A	Homo sapiens	0-3
3244386-11	1988	During the sustained increase in [Ca2+]cyt induced by noradrenaline (10 mumol/l) or high K+ (140 mmol/l), addition of caffeine transiently increased [Ca2+]cyt followed by a decrease to a level slightly lower than that before the addition of caffeine.	Norepinephrine	54-67	carbonic anhydrase 2	Rattus norvegicus	34-37
3418519-0	1988	Norepinephrine and potassium induced calcium translocation in rat vas deferens.	Norepinephrine	0-14	arginine vasopressin	Rattus norvegicus	66-69
3141200-1	1988	Intravenous injection of the synthetic TRH analog, MK-771, to anesthetised cats raised the blood pressure by a central mechanism, i.e. by activating the outflow of sympathetic stimuli from the CNS to the periphery and raising the plasma concentration of adrenaline and noradrenaline.	Norepinephrine	269-282	thyrotropin releasing hormone	Felis catus	39-42
2848203-9	1988	Furthermore, the beta 2-adrenoceptor-induced facilitation of noradrenaline release may in part be mediated by local stimulation of angiotensin II synthesis, which may occur by increased formation or activation of renin and/or increased availability of angiotensinogen.	Norepinephrine	61-74	angiotensinogen	Homo sapiens	131-145
2848203-9	1988	Furthermore, the beta 2-adrenoceptor-induced facilitation of noradrenaline release may in part be mediated by local stimulation of angiotensin II synthesis, which may occur by increased formation or activation of renin and/or increased availability of angiotensinogen.	Norepinephrine	61-74	renin	Homo sapiens	213-218
3231703-6	1988	Na+-depletion increased the sensitivity of the vas deferens to exogenous noradrenaline.	Norepinephrine	73-86	arginine vasopressin	Rattus norvegicus	47-50
2850308-6	1988	It appears that the acute cardiovascular response to gamma-MSH administration depends primarily on the release of sympathetic terminal norepinephrine, though some contribution from other pressor systems such as adrenal catecholamines is possible.	Norepinephrine	135-149	proopiomelanocortin	Homo sapiens	53-62
2843627-1	1988	Neuropeptide Y (NPY) is known to potentiate the pressor effect of norepinephrine.	Norepinephrine	66-80	neuropeptide Y	Rattus norvegicus	0-14
2843627-1	1988	Neuropeptide Y (NPY) is known to potentiate the pressor effect of norepinephrine.	Norepinephrine	66-80	neuropeptide Y	Rattus norvegicus	16-19
2843627-2	1988	In the present work, we evaluated in unanesthetized normotensive rats the effect of NPY on blood pressure responsiveness not only to norepinephrine, but also to tyramine, a sympathomimetic agent acting indirectly to B-HT933, a selective alpha-2 adrenoceptor stimulant, to angiotensin II and vasopressin.	Norepinephrine	133-147	neuropeptide Y	Rattus norvegicus	84-87
2843627-6	1988	NPY significantly enhanced the pressor effect of norepinephrine, tyramine and angiotensin II, but not that of B-HT933 and vasopressin.	Norepinephrine	49-63	neuropeptide Y	Rattus norvegicus	0-3
2843627-9	1988	It appears therefore that the blood pressure potentiating effect of NPY is not restricted to alpha adrenoceptor stimulation with norepinephrine, but involves also the vasoconstrictor hormone angiotensin II.	Norepinephrine	129-143	neuropeptide Y	Rattus norvegicus	68-71
3418519-7	1988	Studies of the efflux of 45Ca from vas deferens revealed that efflux was not affected by potassium but was significantly stimulated by norepinephrine.	Norepinephrine	135-149	arginine vasopressin	Rattus norvegicus	35-38
2841357-5	1988	The mechanism by which angiotensin II regulates intestinal sodium transport is by potentiating sympathetic nerve activity and norepinephrine release.	Norepinephrine	126-140	angiotensinogen	Rattus norvegicus	23-37
2970434-4	1988	For this reason, the behavior of supine and upright plasma ANF as related to aldosterone, blood pressure, and forearm alpha-adrenergic sensitivity (plethysmographic technique) to intra-arterial norepinephrine infusion was studied in eight patients with primary aldosteronism (five with adenomas, three with hyperplasia) before and at the end of two sequential 1-week low (20 mmol/day) and high sodium (200 mmol/day) diet periods.	Norepinephrine	194-208	natriuretic peptide A	Homo sapiens	59-62
3208091-7	1988	Sympathetic neurons initially selected in culture by nerve growth factor in regular medium and then exposed to a conditioned medium for 3 days exhibited a marked facilitation of [3H]norepinephrine uptake.	Norepinephrine	182-196	nerve growth factor	Gallus gallus	53-72
2847059-6	1988	From our experiments it may be concluded that angiotensin II induces tachycardia in the pithed rat primarily by stimulating the sympathetic ganglia leading to the release of noradrenaline, which subsequently activates cardiac beta 1-adrenoceptors.	Norepinephrine	174-187	angiotensinogen	Rattus norvegicus	46-60
3211156-0	1988	Full expression of uncoupling protein gene requires the concurrence of norepinephrine and triiodothyronine.	Norepinephrine	71-85	uncoupling protein 1	Rattus norvegicus	19-29
3404443-6	1988	The renal vasoconstriction elicited by norepinephrine and arginine vasopressin as well as by angiotensin II was enhanced by NPY.	Norepinephrine	39-53	neuropeptide Y	Rattus norvegicus	124-127
3138577-4	1988	Our results suggest differential effects of noradrenaline on the release of AVP and CRF-41 into HPB.	Norepinephrine	44-57	arginine vasopressin	Homo sapiens	76-79
3224899-2	1988	Application of vasodilators (acetylcholine, isoproterenol, histamine, bradykinin and substance P) to the prepared cavity caused an increase in PBF, and norepinephrine reduced PBF.	Norepinephrine	152-166	kininogen 1	Canis lupus familiaris	70-80
2905364-8	1988	There were few or no PNMT-immunoreactive cells caudal to the obex, indicating that the TH-immunoreactive cells in this region synthesize either noradrenaline or dopamine.	Norepinephrine	144-157	tyrosine hydroxylase	Homo sapiens	87-89
2902135-3	1988	In all three situations, renin activity was closely correlated with noradrenaline levels in the phaeochromocytoma patients (r = 0.545, r = 0.600, and r = 0.739; P less than 0.01) but not in the subjects with primary hypertension or in the volunteers.	Norepinephrine	68-81	renin	Homo sapiens	25-30
3262452-4	1988	Incubation of rat aortas with human monocyte-derived interleukin 1 or recombinant human tumor necrosis factor resulted in diminished aortic contraction and sensitivity to norepinephrine, and gel filtration of medium conditioned by endotoxin-stimulated macrophages yielded suppressive activity at a molecular weight equivalent to interleukin 1 and tumor necrosis factor.	Norepinephrine	171-185	tumor necrosis factor	Homo sapiens	88-109
3383374-5	1988	Norepinephrine also induced a transient and dose-dependent elevation of cytosolic Ca2+ in the absence of extracellular Ca2+.	Norepinephrine	0-14	carbonic anhydrase 2	Rattus norvegicus	82-85
3394823-4	1988	In hypertensive patients, norepinephrine (40 ng.kg-1.min-1) induced 1) a significant decrease in brachial artery diameter, local blood velocity, volumic flow, and conductance and 2) a small increase in mean arterial pressure.	Norepinephrine	26-40	CD59 molecule (CD59 blood group)	Homo sapiens	53-58
3394838-6	1988	Vasopressin increased from 1.2 +/- 0.3 to 137 +/- 45 pg/ml and renin activity increased from 1.45 +/- 4.0 to 3.80 +/- 1.0 ng.ml-1.h-1 with no further changes in epinephrine, norepinephrine, and vasoactive intestinal polypeptide.	Norepinephrine	174-188	arginine vasopressin	Homo sapiens	0-11
3394838-6	1988	Vasopressin increased from 1.2 +/- 0.3 to 137 +/- 45 pg/ml and renin activity increased from 1.45 +/- 4.0 to 3.80 +/- 1.0 ng.ml-1.h-1 with no further changes in epinephrine, norepinephrine, and vasoactive intestinal polypeptide.	Norepinephrine	174-188	renin	Homo sapiens	63-68
2902135-6	1988	These findings show that in phaeochromocytoma, hypertension is accompanied by high renin levels and that renin release is stimulated in response to noradrenaline overflow.	Norepinephrine	148-161	renin	Homo sapiens	105-110
2845292-2	1988	Does noradrenaline mediate the actions of endogenous opioids on oxytocin and vasopressin release?	Norepinephrine	5-18	arginine vasopressin	Rattus norvegicus	77-88
3179612-12	1988	In a Ca2+-free solution, noradrenaline and caffeine induced a transient contraction in the aorta, whereas a second application of each stimulant was almost ineffective.	Norepinephrine	25-38	carbonic anhydrase 2	Oryctolagus cuniculus	5-8
3294177-7	1988	In patients with essential hypertension, intracellular sodium and free calcium concentrations were negatively correlated with plasma renin activity (r = -0.66, p less than 0.001; r = -0.60, p less than 0.001, plasma norepinephrine concentration.	Norepinephrine	216-230	renin	Homo sapiens	133-138
3258558-10	1988	Plasma noradrenaline levels were transiently increased after 10 and 25 micrograms of hCGRP.	Norepinephrine	7-20	calcitonin related polypeptide alpha	Homo sapiens	85-90
3049097-2	1988	Angiotensin converting enzyme (ACE) inhibitors reduce circulating levels of angiotensin II and aldosterone and, in some patients, plasma noradrenaline, vasopressin and cortisol.	Norepinephrine	137-150	angiotensin I converting enzyme	Homo sapiens	0-29
3049097-2	1988	Angiotensin converting enzyme (ACE) inhibitors reduce circulating levels of angiotensin II and aldosterone and, in some patients, plasma noradrenaline, vasopressin and cortisol.	Norepinephrine	137-150	angiotensin I converting enzyme	Homo sapiens	31-34
2968309-8	1988	Plasma norepinephrine levels and peripheral resistance increased (34% and 9%, respectively) during ANF administration.	Norepinephrine	7-21	natriuretic peptide A	Homo sapiens	99-102
2457640-2	1988	), interferon (IFN), and activity of NK cells in the blood was examined in groups of young males during a 30 min exposure to 39 degrees C and 4 degrees C. A quick release of somatotropin was registered in 44% of examinees in the hyperthermic group, while the persons exposed to 4 degrees C reacted with a release of noradrenaline only.	Norepinephrine	316-329	growth hormone 1	Homo sapiens	174-186
2899848-8	1988	Results of this study support the hypothesis that epinephrine and/or norepinephrine regulate the release of ACTH and vasopressin via alpha-1- and alpha-2-adrenergic receptors associated with CRF- and VP-containing somata within the PVN.	Norepinephrine	69-83	proopiomelanocortin	Homo sapiens	108-112
2899848-8	1988	Results of this study support the hypothesis that epinephrine and/or norepinephrine regulate the release of ACTH and vasopressin via alpha-1- and alpha-2-adrenergic receptors associated with CRF- and VP-containing somata within the PVN.	Norepinephrine	69-83	arginine vasopressin	Homo sapiens	117-128
3187058-1	1988	The role of arachidonic acid metabolites in norepinephrine (NE)-induced N-acetyltransferase (NAT) activity and melatonin release was examined from 6 h-incubations of rat pineal glands.	Norepinephrine	44-58	N-acetyltransferase 1	Rattus norvegicus	72-91
3187058-1	1988	The role of arachidonic acid metabolites in norepinephrine (NE)-induced N-acetyltransferase (NAT) activity and melatonin release was examined from 6 h-incubations of rat pineal glands.	Norepinephrine	44-58	N-acetyltransferase 1	Rattus norvegicus	93-96
2837695-0	1988	Cholecystokinin modulation of [3H]noradrenaline release from superfused hypothalamic slices.	Norepinephrine	34-47	cholecystokinin	Homo sapiens	0-15
2966770-7	1988	Human ANF-(99-126) infusion decreased BP (p less than 0.05-0.01), produced hemoconcentration (hematocrit + 7%; p less than 0.01) without negative body fluid balance, and increased (p less than 0.01-0.001) plasma norepinephrine, insulin, and serum free fatty acids; plasma aldosterone and renin activity were unaltered during but rose after cessation of human ANF-(99-126) infusion.	Norepinephrine	212-226	natriuretic peptide A	Homo sapiens	6-9
3042578-0	1988	Insulin modulates early-phase noradrenaline response to glucose ingestion in humans.	Norepinephrine	30-43	insulin	Homo sapiens	0-7
2843832-3	1988	NPY was at least 200-fold more potent than norepinephrine or adenosine to produce an equivalent inhibition.	Norepinephrine	43-57	neuropeptide Y	Rattus norvegicus	0-3
3381909-6	1988	Norepinephrine infusion (with minipumps), which prevented denervation-induced BAT atrophy and reduction in mitochondrial content of UCP in rats, caused pronounced loss of tissue mass and mitochondrial proteins in hamsters and did not prevent the loss of UCP observed in mitochondria isolated from the denervated pad.	Norepinephrine	0-14	uncoupling protein 1	Rattus norvegicus	132-135
3389390-0	1988	Effects of infused norepinephrine and angiotensin-II on vasopressin levels in humans.	Norepinephrine	19-33	arginine vasopressin	Homo sapiens	56-67
2843784-5	1988	The predominantly beta 1-adrenergic receptor antagonists, practolol and metoprolol shifted the concentration-response curve to noradrenaline to the right, with apparent Ki values of 8.0 x 10(-7) M and 7.6 x 10(-8) M, respectively, close to those reported in the rat heart.	Norepinephrine	127-140	adrenoceptor beta 1	Rattus norvegicus	18-44
2452035-6	1988	In contrast, SP caused dilatation of veins preconstricted with norepinephrine, although the effect was only transient and dose-response curves could not be constructed.	Norepinephrine	63-77	tachykinin precursor 1	Homo sapiens	13-15
2843832-12	1988	The inhibitory action of NPY is best explained through the activation of presynaptic NPY receptors that regulate norepinephrine release via a negative feedback mechanism.	Norepinephrine	113-127	neuropeptide Y	Rattus norvegicus	25-28
2843832-12	1988	The inhibitory action of NPY is best explained through the activation of presynaptic NPY receptors that regulate norepinephrine release via a negative feedback mechanism.	Norepinephrine	113-127	neuropeptide Y	Rattus norvegicus	85-88
2978742-0	1988	Response of atrial natriuretic peptide to adrenaline and noradrenaline infusion in man.	Norepinephrine	57-70	natriuretic peptide A	Homo sapiens	12-38
2978742-2	1988	Atrial natriuretic peptide (ANP) levels were significantly increased during both adrenaline and noradrenaline infusions, in the physiological range, in normal subjects and in patients with essential hypertension.	Norepinephrine	96-109	natriuretic peptide A	Homo sapiens	0-26
2978742-2	1988	Atrial natriuretic peptide (ANP) levels were significantly increased during both adrenaline and noradrenaline infusions, in the physiological range, in normal subjects and in patients with essential hypertension.	Norepinephrine	96-109	natriuretic peptide A	Homo sapiens	28-31
3284873-4	1988	Studies were performed without prior exercise, as well as 2 and 48 h after 60 min of bicycle exercise at 150 W. We found 1) a progressive increase in insulin concentrations reaching 1,092 +/- 135 microU/ml with increasing glucose levels, 2) linear relationships between glucose concentrations and concentrations of C-peptide (r = 0.931 +/- 0.008) and proinsulin (r = 0.952 +/- 0.009),3) increased glucose oxidation with increasing glucose uptake, 4) increased plasma norepinephrine, O2 uptake, and beta-hydroxybutyrate at greater than or equal to 20 mM glucose, and 5) no change in beta-cell response or glucose-induced thermogenesis after one bout of exercise despite no compensating changes in plasma concentrations of hormones or metabolites.	Norepinephrine	467-481	insulin	Homo sapiens	150-157
2975466-6	1988	The increase in plasma renin activity that followed the reduction in central venous pressure was drastically attenuated in four patients who had undergone cardiac transplantation, along with other reflex effects (changes in forearm vascular resistance and plasma norepinephrine) of cardiopulmonary receptor manipulations.	Norepinephrine	263-277	renin	Homo sapiens	23-28
3361453-0	1988	Release, metabolism and intraneuronal disposition of exogenous, endogenous and newly synthesized norepinephrine in the rat vas deferens.	Norepinephrine	97-111	arginine vasopressin	Rattus norvegicus	123-126
2837885-10	1988	These results suggest the etiologic possibility that the patients have a decreased dopaminergic inhibition of prostaglandin E2-mediated norepinephrine secretion, which causes periodic discharge of norepinephrine and concomitant release of ACTH and AVP.	Norepinephrine	136-150	proopiomelanocortin	Homo sapiens	239-243
2833995-0	1988	Vasopressin potentiates the noradrenaline-induced accumulation of cyclic AMP in the rat superior cervical ganglion.	Norepinephrine	28-41	arginine vasopressin	Rattus norvegicus	0-11
2833995-2	1988	This work was designed to investigate whether there was an action of vasopressin on the noradrenaline-induced cyclic AMP accumulation through the activation of phospholipase C. Our results clearly demonstrate that arginine-vasopressin potentiates cyclic AMP accumulation induced by noradrenaline or isoproterenol in a concentration-dependent manner.	Norepinephrine	88-101	arginine vasopressin	Rattus norvegicus	69-80
2833995-2	1988	This work was designed to investigate whether there was an action of vasopressin on the noradrenaline-induced cyclic AMP accumulation through the activation of phospholipase C. Our results clearly demonstrate that arginine-vasopressin potentiates cyclic AMP accumulation induced by noradrenaline or isoproterenol in a concentration-dependent manner.	Norepinephrine	88-101	arginine vasopressin	Rattus norvegicus	223-234
2964401-8	1988	Infusion of angiotensin II (Ang II; 20 ng/kg/min) or norepinephrine (200 ng/kg/min) for 30 minutes to normal volunteers (n = 5) resulted in a rise in MAP (24.9 +/- 3.3 and 15.8 +/- 4.4 mm Hg, respectively) and a twofold increase in plasma ANF level.	Norepinephrine	53-67	natriuretic peptide A	Homo sapiens	239-242
2833995-2	1988	This work was designed to investigate whether there was an action of vasopressin on the noradrenaline-induced cyclic AMP accumulation through the activation of phospholipase C. Our results clearly demonstrate that arginine-vasopressin potentiates cyclic AMP accumulation induced by noradrenaline or isoproterenol in a concentration-dependent manner.	Norepinephrine	282-295	arginine vasopressin	Rattus norvegicus	69-80
2833995-2	1988	This work was designed to investigate whether there was an action of vasopressin on the noradrenaline-induced cyclic AMP accumulation through the activation of phospholipase C. Our results clearly demonstrate that arginine-vasopressin potentiates cyclic AMP accumulation induced by noradrenaline or isoproterenol in a concentration-dependent manner.	Norepinephrine	282-295	arginine vasopressin	Rattus norvegicus	223-234
3126665-0	1988	Norepinephrine uptake by rat jejunum: modulation by angiotensin II.	Norepinephrine	0-14	angiotensinogen	Rattus norvegicus	52-66
3126665-2	1988	This study is designed to determine whether ANG II can enhance sympathetic neurotransmission within the small intestine by inhibiting norepinephrine (NE) uptake.	Norepinephrine	134-148	angiotensinogen	Rattus norvegicus	44-50
2906518-3	1988	Hypothalamic CRH released from the hypothalamic neuron not only activates the HPA axis, but also stimulates the locus coeruleus-norepinephrine system (LC) and the central sympathetic system (CSS).	Norepinephrine	128-142	corticotropin releasing hormone	Rattus norvegicus	13-16
2896801-2	1988	Administration of a single dose of kainate (50 micrograms) to the peripheral noradrenergic ganglia innervating the vas deferens induced a time-dependent decrease of norepinephrine in the organ; after 10 days the norepinephrine concentration had fallen to 35% of control values.	Norepinephrine	165-179	arginine vasopressin	Rattus norvegicus	115-118
2896801-2	1988	Administration of a single dose of kainate (50 micrograms) to the peripheral noradrenergic ganglia innervating the vas deferens induced a time-dependent decrease of norepinephrine in the organ; after 10 days the norepinephrine concentration had fallen to 35% of control values.	Norepinephrine	212-226	arginine vasopressin	Rattus norvegicus	115-118
3335518-6	1988	Norepinephrine production was strictly magnesium-ATP-dependent, inhibited by either reserpine or dopamine beta-monooxygenase inactivation, and was markedly reduced when ascorbate was omitted from either inside or outside the ghosts.	Norepinephrine	0-14	dopamine beta-hydroxylase	Bos taurus	97-124
3335518-8	1988	The endogenous rate of norepinephrine production likely represents epinephrine-supported dopamine beta-monooxygenase turnover.	Norepinephrine	23-37	dopamine beta-hydroxylase	Bos taurus	89-116
3335518-9	1988	Taken together, the data demonstrate that facile norepinephrine production by membrane-bound dopamine beta-monooxygenase occurs only when internal ascorbate is present, terminates upon depletion of internal ascorbate, and can only be sustained at a significant rate when reducing equivalents from external ascorbate are available.	Norepinephrine	49-63	dopamine beta-hydroxylase	Bos taurus	93-120
3250182-5	1988	In vessels precontracted by noradrenalin 10(-5) M, VIP 10(-8) - 10(-6) M and PHM 10(-8) - 10(-6) M induced similar, concentration-dependent relaxation with a maximum effect of 73.2 +/- 12.7% relaxation for VIP 10(-6) M and 79.6 +/- 11.8% for PHM 10(-6) M, as compared to 10.7 +/- 3.1% decrease in tension for control preparations treated with solvent (mean +/- SE, n = 6).	Norepinephrine	28-40	vasoactive intestinal peptide	Homo sapiens	51-54
3279724-10	1988	The changes in plasma noradrenaline as related to blood pressure, heart rate, plasma renin activity and angiotensin II during long-term felodipine treatment may reflect decreased cardiac and renal beta-adrenoceptor-mediated responses.	Norepinephrine	22-35	angiotensinogen	Homo sapiens	104-118
2456971-5	1988	Both peptides showed potent relaxing effects on vessels precontracted by noradrenaline 10(-5) M. Substance P exhibited the higher potency, while human CGRP showed the higher efficacy.	Norepinephrine	73-86	tachykinin precursor 1	Homo sapiens	97-108
2851918-0	1988	Neuropeptide Y (NPY) induced inhibition of preganglionic nerve stimulation evoked release of adrenalin and noradrenaline in the pithed rat.	Norepinephrine	107-120	neuropeptide Y	Rattus norvegicus	0-14
2851918-0	1988	Neuropeptide Y (NPY) induced inhibition of preganglionic nerve stimulation evoked release of adrenalin and noradrenaline in the pithed rat.	Norepinephrine	107-120	neuropeptide Y	Rattus norvegicus	16-19
2851918-1	1988	NPY, a peptide with 36 amino acid residues, is co-stored together with noradrenaline (NA) in cardiac and sympathetic perivascular nerves as well as with adrenalin (A) in adrenal chromaffin cells.	Norepinephrine	71-84	neuropeptide Y	Rattus norvegicus	0-3
2839312-4	1988	These results suggest that an increase in specific ACE activity of the amygdaloid complex after norepinephrine depletion could play a role in the development of hypertension in this model.	Norepinephrine	96-110	angiotensin I converting enzyme	Homo sapiens	51-54
3367684-1	1988	Neuropeptide Y (NPY) is a vasoconstrictor present in the sympatho-adrenomedullary system and may be co-released with norepinephrine (NE) and epinephrine (EPI) during sympathetic activation.	Norepinephrine	117-131	neuropeptide Y	Rattus norvegicus	0-14
3056815-5	1988	The hormonal responses of epinephrine, norepinephrine, prolactin, hGH, and cortisol were attenuated following proinsulin.	Norepinephrine	39-53	insulin	Homo sapiens	110-120
2852643-2	1988	A large body of in vitro and in vivo animal data indicate that angiotensin II regulates noradrenaline release and modifies sympathetic reflexes, although the physiological relevance of these to normal man remains unclear.	Norepinephrine	88-101	angiotensinogen	Homo sapiens	63-77
2852643-4	1988	The hypothesis was therefore examined that angiotensin II exerts a pre-junctional effect on noradrenaline release and sympathetic cardiovascular function, in the elderly and in patients with essential hypertension.	Norepinephrine	92-105	angiotensinogen	Homo sapiens	43-57
3276713-6	1988	In PC12 cells transfected with DNA encoding human growth hormone, the hormone was packaged and released with norepinephrine.	Norepinephrine	109-123	growth hormone 1	Homo sapiens	50-64
3367684-1	1988	Neuropeptide Y (NPY) is a vasoconstrictor present in the sympatho-adrenomedullary system and may be co-released with norepinephrine (NE) and epinephrine (EPI) during sympathetic activation.	Norepinephrine	117-131	neuropeptide Y	Rattus norvegicus	16-19
20501252-3	1988	When applied simultaneously with adenosine or noradrenaline, VIP depressed the firing of cortical neurons, but this depression could be reproduced by the passage of similar positive currents through a 50 mM NaCl-containing barrel of the multiple barrelled micropipette.	Norepinephrine	46-59	vasoactive intestinal peptide	Rattus norvegicus	61-64
20501252-5	1988	Leakage of adenosine or noradrenaline during iontophoretic applications of the peptide may account for the reported inhibitory actions of VIP.	Norepinephrine	24-37	vasoactive intestinal peptide	Rattus norvegicus	138-141
3212674-6	1988	Infusion of a low pressor (8.5 +/- 1.5 mm Hg) dose of norepinephrine into conscious rats potentiated NPY-mediated pressor responses 2-fold and also tended to increase bradycardic effect of a higher dose of NPY (by 19%).	Norepinephrine	54-68	neuropeptide Y	Rattus norvegicus	101-104
3154507-9	1988	However, in a limited number of the schizophrenic patients in this population, a significant correlation was seen between neurotensin and the noradrenaline metabolite MOPEG.	Norepinephrine	142-155	neurotensin	Homo sapiens	122-133
2850631-5	1988	NPY was also seen to decrease the potassium-induced release of norepinephrine (NE) from slices obtained from the posterior hypothalamic nucleus.	Norepinephrine	63-77	neuropeptide Y	Rattus norvegicus	0-3
3212674-6	1988	Infusion of a low pressor (8.5 +/- 1.5 mm Hg) dose of norepinephrine into conscious rats potentiated NPY-mediated pressor responses 2-fold and also tended to increase bradycardic effect of a higher dose of NPY (by 19%).	Norepinephrine	54-68	neuropeptide Y	Rattus norvegicus	206-209
2850686-0	1988	[Beta adrenergic receptor-induced stimulation of the vascular renin-angiotensin system: significance for noradrenaline liberation and the mechanism of action of angiotensin-converting enzyme inhibitors].	Norepinephrine	105-118	renin	Homo sapiens	62-67
3126463-1	1987	The neuropeptide Y (NPY) innervation of the hypothalamus is thought to arise largely from noradrenaline (NA) neurons of the medullary tegmentum in the rat.	Norepinephrine	90-103	neuropeptide Y	Rattus norvegicus	4-18
3683090-1	1987	This study in conscious normotensive rats was performed to assess the effect of the vasoconstrictor peptide, neuropeptide Y (NPY), on blood pressure responsiveness to exogenous norepinephrine in endotoxaemia.	Norepinephrine	177-191	neuropeptide Y	Rattus norvegicus	109-123
3683090-1	1987	This study in conscious normotensive rats was performed to assess the effect of the vasoconstrictor peptide, neuropeptide Y (NPY), on blood pressure responsiveness to exogenous norepinephrine in endotoxaemia.	Norepinephrine	177-191	neuropeptide Y	Rattus norvegicus	125-128
3442241-1	1987	Neuropeptide Y is co-stored with noradrenaline in peripheral sympathetic nerves, but is not present in the adrenal chromaffin cells in the pig.	Norepinephrine	33-46	neuropeptide Y	Sus scrofa	0-14
3425755-4	1987	Arterioles and venules, which were preconstricted with norepinephrine, dilated to their initial baseline diameters after angiotensin II (10(-6) M), a response not observed when the microvessels were pretreated with either an angiotensin antagonist or a prostaglandin synthesis inhibitor.	Norepinephrine	55-69	angiotensinogen	Rattus norvegicus	121-135
3126463-1	1987	The neuropeptide Y (NPY) innervation of the hypothalamus is thought to arise largely from noradrenaline (NA) neurons of the medullary tegmentum in the rat.	Norepinephrine	90-103	neuropeptide Y	Rattus norvegicus	20-23
2824175-2	1987	Because adrenergic neurotransmitters, norepinephrine (NE) and epinephrine (E), show intraneuronal coexistence with NPY in certain brain regions of the rat and there are similarities in the effects of NPY and NE/E on LH release, we investigated the possible interaction of NPY and adrenergic receptor systems in the stimulation of LH release in EBP-treated ovariectomized rats.	Norepinephrine	38-52	neuropeptide Y	Rattus norvegicus	115-118
3453392-0	1987	Angiotensin II potentiates the vasoconstrictive effect of norepinephrine in normotensive and hypertensive man.	Norepinephrine	58-72	angiotensinogen	Homo sapiens	0-14
3453392-2	1987	Angiotensin II given in subpressor doses has been shown to enhance the vasoconstrictive effect of norepinephrine in several animal models.	Norepinephrine	98-112	angiotensinogen	Homo sapiens	0-14
3453392-3	1987	However, the effects of subpressor doses of angiotensin II on the vasoconstrictor effects of norepinephrine have not been reported in humans.	Norepinephrine	93-107	angiotensinogen	Homo sapiens	44-58
3453392-4	1987	We found that angiotensin II, given in subpressor doses, potentiates the vascular response of norepinephrine in normotensive and hypertensive male subjects.	Norepinephrine	94-108	angiotensinogen	Homo sapiens	14-28
3440094-0	1987	The effect of angiotensin II on endogenous noradrenaline release in man.	Norepinephrine	43-56	angiotensinogen	Homo sapiens	14-28
3326056-7	1987	By immunocytochemistry gamma 2-MSH immunoreactivity was localized to the adrenocorticotropin/alpha-MSH cells in the pituitary and to a subpopulation of the noradrenaline-storing cells in the adrenal medulla.	Norepinephrine	156-169	proopiomelanocortin	Homo sapiens	31-34
3440094-2	1987	Considerable data from animal studies suggest that angiotensin II exerts a facilitatory effect on noradrenaline release.	Norepinephrine	98-111	angiotensinogen	Homo sapiens	51-65
3440094-3	1987	We sought evidence for such an effect in man by examining how a subpressor dose of angiotensin II (1.5 ng kg-1 min-1) influences the haemodynamic and plasma noradrenaline responses to physiological stimulation of the sympathetic nervous system.	Norepinephrine	157-170	angiotensinogen	Homo sapiens	83-97
3440094-3	1987	We sought evidence for such an effect in man by examining how a subpressor dose of angiotensin II (1.5 ng kg-1 min-1) influences the haemodynamic and plasma noradrenaline responses to physiological stimulation of the sympathetic nervous system.	Norepinephrine	157-170	CD59 molecule (CD59 blood group)	Homo sapiens	111-116
3429867-1	1987	Much animal evidence exists to suggest that there is an interaction between noradrenaline (NA) and angiotensin II (AII).	Norepinephrine	76-89	angiotensinogen	Homo sapiens	99-113
3429867-1	1987	Much animal evidence exists to suggest that there is an interaction between noradrenaline (NA) and angiotensin II (AII).	Norepinephrine	76-89	angiotensinogen	Homo sapiens	115-118
2891801-2	1987	Antisera directed against the enzymes tyrosine hydroxylase (TH), which converts tyrosine to DOPA, and phenylethanolamine N-methyl-transferase (PNMT), which converts norepinephrine to epinephrine, were used with conventional immunohistochemical techniques.	Norepinephrine	165-179	phenylethanolamine N-methyltransferase	Mustela putorius furo	102-141
2891801-2	1987	Antisera directed against the enzymes tyrosine hydroxylase (TH), which converts tyrosine to DOPA, and phenylethanolamine N-methyl-transferase (PNMT), which converts norepinephrine to epinephrine, were used with conventional immunohistochemical techniques.	Norepinephrine	165-179	phenylethanolamine N-methyltransferase	Mustela putorius furo	143-147
3688263-1	1987	Neuropeptide Y (NPY) is contained in and coreleased with norepinephrine (NE) from sympathetic nerves innervating vascular and cardiac tissues.	Norepinephrine	57-71	neuropeptide Y	Rattus norvegicus	0-14
3427417-5	1987	One week after the behavioral experiments, a repeated microinjection of anti-vasopressin serum decreased the local alpha-methyl-p-tyrosine methylester (alpha-MPT)-induced disappearance of noradrenaline in the ventral hippocampus and the dorsal hippocampus respectively.	Norepinephrine	188-201	arginine vasopressin	Rattus norvegicus	77-88
2833189-0	1987	Stimulation of vascular postsynaptic alpha 1-adrenoceptors by noradrenaline, released by angiotensin II in pithed rat preparations.	Norepinephrine	62-75	angiotensinogen	Rattus norvegicus	89-103
2833189-3	1987	These findings suggest that part of the pressor response of high doses of angiotensin II is caused by the liberation of endogenous noradrenaline from the sympathetic nerve endings, but not by that of adrenaline from the adrenal medulla.	Norepinephrine	131-144	angiotensinogen	Rattus norvegicus	74-88
2833189-6	1987	In higher doses, angiotensin II causes vasoconstriction which is mediated partly by the release of noradrenaline from sympathetic nerve endings, leading to activation of predominantly postsynaptic alpha 1-adrenoceptors.	Norepinephrine	99-112	angiotensinogen	Rattus norvegicus	17-31
3481814-2	1987	We sought evidence for a similar interaction in man, to determine whether this interaction is presynaptic, whereby angiotensin II (ANG II) facilitates noradrenaline (NA) release, or postsynaptic, whereby ANG II facilitates the effect of NA.	Norepinephrine	151-164	angiotensinogen	Homo sapiens	131-137
3688263-1	1987	Neuropeptide Y (NPY) is contained in and coreleased with norepinephrine (NE) from sympathetic nerves innervating vascular and cardiac tissues.	Norepinephrine	57-71	neuropeptide Y	Rattus norvegicus	16-19
2826568-4	1987	beta-Endorphin also markedly increased plasma concentrations of epinephrine, norepinephrine and, to a lesser extent, dopamine.	Norepinephrine	77-91	proopiomelanocortin	Homo sapiens	0-14
3427548-0	1987	Effect of short-term administration of vasopressin on arterial pressure and norepinephrine turnover in Long-Evans rats.	Norepinephrine	76-90	arginine vasopressin	Rattus norvegicus	39-50
2891636-6	1987	Since there are no major fluctuations in the water content of the tubal tissues in the three phases, the observed changes in VIP levels represent real fluctuations at the neural level in a manner similar to that previously shown for the neurotransmitter norepinephrine.	Norepinephrine	254-268	vasoactive intestinal peptide	Homo sapiens	125-128
3426346-1	1987	Using the oil immersion technique, the role of neuronal uptake, monoamine oxidase and COMT in the inactivation of 2 concentrations (0.23 and 2.3 mumol/l) of noradrenaline and adrenaline was determined by the prolongation of the inactivation time caused by cocaine (12 mumol/l), pargyline (1 mmol/l) and U-0521 (50 mumol/l), respectively.	Norepinephrine	157-170	catechol-O-methyltransferase	Canis lupus familiaris	86-90
2444796-0	1987	Prejunctional beta 2-adrenoceptor-mediated enhancement of noradrenaline release in skeletal muscle vasculature in situ.	Norepinephrine	58-71	beta-2 adrenergic receptor	Canis lupus familiaris	14-33
3115818-4	1987	Pretreatment with 2 nmol NPY enhanced the noradrenaline-induced pressor response in control rats.	Norepinephrine	42-55	neuropeptide Y	Rattus norvegicus	25-28
2891404-1	1987	There is evidence for local regulatory effects of dopamine (DA) and norepinephrine (NE) on the release of prolactin (PRL) and other hormones from the anterior pituitaries transplanted to an ectopic site.	Norepinephrine	68-82	prolactin	Rattus norvegicus	106-115
2891404-1	1987	There is evidence for local regulatory effects of dopamine (DA) and norepinephrine (NE) on the release of prolactin (PRL) and other hormones from the anterior pituitaries transplanted to an ectopic site.	Norepinephrine	68-82	prolactin	Rattus norvegicus	117-120
2826868-2	1987	The individuals of behavioral type A showed significantly increased noradrenaline excretion with daily urine and serum ACTH levels.	Norepinephrine	68-81	proopiomelanocortin	Homo sapiens	119-123
3115818-5	1987	NPY did not change the basal tension of isolated rat aortic strips but significantly potentiated the contractile activity induced by 16 nM noradrenaline.	Norepinephrine	139-152	neuropeptide Y	Rattus norvegicus	0-3
3117577-1	1987	The neurotoxin, DSP-4, (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride) specifically and significantly reduces norepinephrine (NE) and its metabolite, 3-methoxy-4-hydroxyphenylethylene glycol (MHPG), in cortical, hippocampal and cerebellar brain regions.	Norepinephrine	123-137	dual specificity phosphatase 26	Homo sapiens	16-21
2823971-0	1987	Noradrenaline- and time-dependent changes in neocortical alpha 2- and beta 1-adrenoceptor binding in dorsal noradrenergic bundle-lesioned rats.	Norepinephrine	0-13	adrenoceptor beta 1	Rattus norvegicus	57-89
3440284-0	1987	In vitro effect of neuropeptide Y on melatonin and norepinephrine release in rat pineal gland.	Norepinephrine	51-65	neuropeptide Y	Rattus norvegicus	19-33
3040721-6	1987	The adrenergic agonists isoproterenol and norepinephrine blocked the elevation of cellular c-sis mRNA accompanying exposure to either thrombin or TGF-beta.	Norepinephrine	42-56	coagulation factor II, thrombin	Homo sapiens	134-142
3040721-6	1987	The adrenergic agonists isoproterenol and norepinephrine blocked the elevation of cellular c-sis mRNA accompanying exposure to either thrombin or TGF-beta.	Norepinephrine	42-56	transforming growth factor beta 1	Homo sapiens	146-154
2827680-4	1987	Arginine vasopressin desensitized testis was refractory to luteinizing hormone, follicle stimulating hormone, norepinephrine, dibutyryl cAMP, phorbol-myristate acetate and cholera toxin at 24 h. Arginine vasopressin desensitized testis showed recovery of response to norepinephrine at 48 h after the first injection.	Norepinephrine	267-281	arginine vasopressin	Rattus norvegicus	9-20
2887563-10	1987	The effects of norepinephrine, A23187, and protein kinase C activators appear to be mediated by phospholipase A2 because the effects of these compounds on [3H]arachidonic acid release are blocked by an established inhibitor of this enzyme, mepacrine, and because these compounds stimulate the formation of 32P- and 14C-labeled lysophosphatidylcholine by glands incubated with 32Pi or [14C]choline.	Norepinephrine	15-29	phospholipase A2 group IB	Homo sapiens	96-112
2892840-16	1987	7 Taken together, these findings indicate that post-ganglionic denervation of the epididymal half of the rat vas deferens by medial transection (vasectomy) leads to a slowly developing and prolonged supersensitivity to noradrenaline which is primarily due to the loss of the neuronal uptake facility.	Norepinephrine	219-232	arginine vasopressin	Rattus norvegicus	109-112
3659100-0	1987	The involvement of neuropeptide Y in the antimuricide action of noradrenaline injected into the medial amygdala of olfactory bulbectomized rats.	Norepinephrine	64-77	neuropeptide Y	Rattus norvegicus	19-33
2892840-0	1987	Prolonged supersensitivity to noradrenaline of smooth muscle of the epididymal half of the rat vas deferens denervated by vasectomy.	Norepinephrine	30-43	arginine vasopressin	Rattus norvegicus	95-98
2887563-13	1987	These findings suggest that pineal phospholipase A2 activity is controlled by norepinephrine acting via an alpha 1-adrenergic mechanism which might involve Ca2+ and protein kinase C.	Norepinephrine	78-92	phospholipase A2 group IB	Homo sapiens	35-51
2441031-4	1987	They find that, in the presence of superoxide dismutase (15 micrograms/ml), catalase (65 micrograms/ml), reduced glutathione (5 mM) and NADP+ (0.39 mM), the pump activity was maximal 142% of no norepinephrine at 10(-11) to 10(-10) M norepinephrine and decreased with increasing concentrations of norepinephrine.	Norepinephrine	194-208	catalase	Homo sapiens	76-84
3613861-0	1987	Stimulation of prolactin secretion by L-3,4-dihydroxyphenyl-serine (L-DOPS) via central norepinephrine in the rat.	Norepinephrine	88-102	prolactin	Rattus norvegicus	15-24
2441031-4	1987	They find that, in the presence of superoxide dismutase (15 micrograms/ml), catalase (65 micrograms/ml), reduced glutathione (5 mM) and NADP+ (0.39 mM), the pump activity was maximal 142% of no norepinephrine at 10(-11) to 10(-10) M norepinephrine and decreased with increasing concentrations of norepinephrine.	Norepinephrine	233-247	catalase	Homo sapiens	76-84
2441031-4	1987	They find that, in the presence of superoxide dismutase (15 micrograms/ml), catalase (65 micrograms/ml), reduced glutathione (5 mM) and NADP+ (0.39 mM), the pump activity was maximal 142% of no norepinephrine at 10(-11) to 10(-10) M norepinephrine and decreased with increasing concentrations of norepinephrine.	Norepinephrine	233-247	catalase	Homo sapiens	76-84
3037217-2	1987	In astrocytes, norepinephrine (NE) produced the greatest stimulation with significant increase also observed with bradykinin.	Norepinephrine	15-29	kininogen 1	Homo sapiens	114-124
2824762-17	1987	The outflows of noradrenaline and 3,4-dihydroxyphenylglycol (DOPEG) induced by perivascular nerve stimulation increased with ATP (above 10(-6) M) or AMP-PNP (above 10(-5) M), while there was no change with mATP (10(-8)-10(-5) M) or 10.1 mM-K+o solution.	Norepinephrine	16-29	solute carrier family 45, member 2	Mus musculus	206-210
2824762-19	1987	Pre-treatment with mATP inhibited the ATP-induced increase in the outflow of noradrenaline and DOPEG, and also the ATP-induced enhancement of the amplitude of the e.j.p.	Norepinephrine	77-90	solute carrier family 45, member 2	Mus musculus	19-23
2824762-21	1987	Therefore ATP and AMP-PNP have predominantly excitatory actions on both pre- and post-junctional membranes, while mATP has an excitatory action on the post-junctional membrane but antagonizes the facilitatory action of ATP on release of noradrenaline from the nerve terminal.	Norepinephrine	237-250	solute carrier family 45, member 2	Mus musculus	114-118
3036595-1	1987	Noradrenaline (1-10 microM) inhibited Ca2+-induced insulin secretion from electrically permeabilised islets of Langerhans with an efficacy similar to that for inhibition of glucose-induced insulin secretion from intact islets.	Norepinephrine	0-13	insulin	Homo sapiens	51-58
2885175-2	1987	We compared the effects of sympathetic nerve stimulation to that of pancreatic norepinephrine (NE) infusion on pancreatic somatostatin-like immunoreactivity (SLI) and pancreatic polypeptide (PP) secretion in the halothane-anesthetized dog.	Norepinephrine	79-93	somatostatin	Canis lupus familiaris	122-134
2887164-4	1987	The stimulatory effect of (-)-noradrenaline is antagonized by beta 1-selective metoprolol and also by beta 2-selective ICI 118,551.	Norepinephrine	26-43	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	62-68
3595384-2	1987	The aim of the present study was to investigate if physiologic changes of noradrenaline would evoke any alterations in gastric acid secretion or in the plasma concentration of some gastrointestinal hormones (gastrin, secretin, PP, PYY, and GIP) known to affect gastric physiology.	Norepinephrine	74-87	gastric inhibitory polypeptide	Homo sapiens	240-243
3572405-1	1987	Previous studies have shown that norepinephrine is important in the regulation of central angiotensin II receptors, an effect mediated by alpha 1-adrenergic receptors.	Norepinephrine	33-47	angiotensinogen	Rattus norvegicus	90-104
2886078-2	1987	We hypothesized that activation of cardiac beta 2 receptors by endogenously released epinephrine and norepinephrine during surgical stress would add to the positive chronotropic response mediated by beta 1 stimulation.	Norepinephrine	101-115	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	199-205
3656789-0	1987	L-methionine enhances the contractile response to norepinephrine of rat vas deferens.	Norepinephrine	50-64	arginine vasopressin	Rattus norvegicus	72-75
3656789-1	1987	Under Ca-depleted conditions, the contractile responses of rat vas deferens in the presence of norepinephrine were not elicited until the addition of CaCl2.	Norepinephrine	95-109	arginine vasopressin	Rattus norvegicus	63-66
3591934-0	1987	Norepinephrine metabolism in neuronal cultures is increased by angiotensin II.	Norepinephrine	0-14	angiotensinogen	Rattus norvegicus	63-77
3614553-0	1987	Neonatal administration of a specific neuropeptide Y antiserum alters the vasopressin response to haemorrhage and the hypothalamic content of noradrenaline in rats.	Norepinephrine	142-155	neuropeptide Y	Rattus norvegicus	38-52
2885773-3	1987	These results suggest that the effects of acetylcholine, bradykinin and partially of angiotensin II, depend on the release of norepinephrine and the actions of this neurotransmitter in turn depend on the integrity of the serotonergic system in the lateral septal area.	Norepinephrine	126-140	angiotensinogen	Rattus norvegicus	85-99
3614553-7	1987	However, electrochemical detection of noradrenaline after HPLC revealed significantly higher levels in the hypothalamus, but not brainstem, of NPY-antiserum-treated rats.	Norepinephrine	38-51	neuropeptide Y	Rattus norvegicus	143-146
2883870-4	1987	Thus, beta 1 adrenoceptors may be considered as physiologically innervated receptors mediating responses to neuronally released norepinephrine, and beta 2 receptors as mediating responses to circulating catecholamines, particularly epinephrine.	Norepinephrine	128-142	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	6-12
3614553-8	1987	The presence of enduring changes in noradrenaline levels and neurohypophyseal function following neonatal treatment with NPY-antiserum suggests a role for NPY in postnatal organization of the rat hypothalamus.	Norepinephrine	36-49	neuropeptide Y	Rattus norvegicus	155-158
3109862-5	1987	Cortisol, growth hormone (GH), prolactin, epinephrine, and norepinephrine responses occurred more rapidly after insulin than after proinsulin.	Norepinephrine	59-73	insulin	Homo sapiens	112-119
3033415-9	1987	Thus, our results support the existence of a prejunctional beta 2-adrenoceptor mediated mechanism facilitating noradrenaline release in vivo, but provide no evidence to support the idea that physiologically relevant increases in circulating adrenaline levels enhance noradrenergic neurotransmission in skeletal muscle.	Norepinephrine	111-124	beta-2 adrenergic receptor	Canis lupus familiaris	59-78
3494840-8	1987	hCGRP reduced slightly the contraction of the tissue induced by norepinephrine and by adenosine 5"-triphosphate.	Norepinephrine	64-78	calcitonin related polypeptide alpha	Homo sapiens	0-5
3581687-0	1987	Exercise-induced changes in renal function and their relation to plasma noradrenaline in insulin-dependent diabetic children and adolescents.	Norepinephrine	72-85	insulin	Homo sapiens	89-96
3681705-4	1987	30 nM-neuropeptide Y increased the contraction caused by either nerve-released noradrenaline or smooth muscle action potentials.	Norepinephrine	79-92	neuropeptide Y	Rattus norvegicus	6-20
3681705-9	1987	30 nM-neuropeptide Y increased the contraction caused by exogenous noradrenaline, 5-hydroxytryptamine and K in concentrations that gave submaximal contractions.	Norepinephrine	67-80	neuropeptide Y	Rattus norvegicus	6-20
3554241-1	1987	Neuropeptide Y (NPY) is widely distributed in the sympathetic nervous system, where it is colocalized with norepinephrine.	Norepinephrine	107-121	neuropeptide Y	Rattus norvegicus	0-14
3554241-1	1987	Neuropeptide Y (NPY) is widely distributed in the sympathetic nervous system, where it is colocalized with norepinephrine.	Norepinephrine	107-121	neuropeptide Y	Rattus norvegicus	16-19
2884805-0	1987	Prejunctional beta 2-adrenoreceptor blockade reduces nerve stimulation evoked release of endogenous noradrenaline in skeletal muscle in situ.	Norepinephrine	100-113	beta-2 adrenergic receptor	Canis lupus familiaris	14-35
3034033-2	1987	Norepinephrine was infused at doses of 0.1, 0.2 and 0.3 micrograms kg-1 min-1, each for 10 minutes, during control and 3 hours after ramipril administration.	Norepinephrine	0-14	CD59 molecule (CD59 blood group)	Homo sapiens	72-77
2885760-5	1987	Selective blockade of beta 2-adrenoceptors without affecting beta 1-adrenoceptors still enabled both adrenaline and noradrenaline to cause maximum possible increases of contractile force through beta 1-adrenoceptors.	Norepinephrine	116-129	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	195-201
3609381-1	1987	Arginine vasopressin (AVP) action on the lipolysis, both the basic and induced with noradrenaline, was studied in adipocytes isolated from epididymal fat pads of Wistar rats sacrificed after 24-hr food deprivation.	Norepinephrine	84-97	arginine vasopressin	Rattus norvegicus	22-25
3609381-5	1987	Having been added to noradrenaline, however, AVP in concentrations 8 X 10(-7) M and 8 X 10(-9) M decreased lipolytic effect of the former, although the decrease was statistically insignificant.	Norepinephrine	21-34	arginine vasopressin	Rattus norvegicus	45-48
3029331-6	1987	DSIP in the range between 20 and 300 nM significantly enhanced NAT activity induced by 10(-6) M norepinephrine in vitro, and a similar effect was observed with 2nMP-DSIP, a phosphorylated analog.	Norepinephrine	96-110	N-acetyltransferase 1	Rattus norvegicus	63-66
3591377-8	1987	Colonic contraction induced by PNS (P less than 0.01) was dose-dependently reduced by NPY (50-400 pmol min-1; P less than 0.05-0.01) and noradrenaline (1000-6000 pmol min-1; P less than 0.05-0.01).	Norepinephrine	137-150	CD59 molecule (CD59 blood group)	Homo sapiens	103-108
3591377-8	1987	Colonic contraction induced by PNS (P less than 0.01) was dose-dependently reduced by NPY (50-400 pmol min-1; P less than 0.05-0.01) and noradrenaline (1000-6000 pmol min-1; P less than 0.05-0.01).	Norepinephrine	137-150	CD59 molecule (CD59 blood group)	Homo sapiens	167-172
3591377-12	1987	Similarly, noradrenaline only at the highest dose (6000 pmol min-1) reduced the contractile response (P less than 0.01).	Norepinephrine	11-24	CD59 molecule (CD59 blood group)	Homo sapiens	61-66
3557600-8	1987	Kidney norepinephrine content was reduced 95% by the denervation procedure and by 40% following infusion of angiotensin II into rats with intact renal nerves.	Norepinephrine	7-21	angiotensinogen	Rattus norvegicus	108-122
3585225-0	1987	Possible role of dopamine and noradrenaline in the regulation of prolactin secretion from an ectopic anterior pituitary gland in female rats.	Norepinephrine	30-43	prolactin	Rattus norvegicus	65-74
3585225-10	1987	These results suggest that dopamine and noradrenaline present in the ectopic pituitary tissue have a role in mediating prolactin release from pituitary transplants.	Norepinephrine	40-53	prolactin	Rattus norvegicus	119-128
2959419-0	1987	Effects of angiotensin and noradrenaline on atrial natriuretic peptide levels in man.	Norepinephrine	27-40	natriuretic peptide A	Homo sapiens	44-70
2959419-2	1987	A significant positive correlation was found between changes in circulating noradrenaline (NA) levels and changes in atrial natriuretic peptide (ANP) levels during NA infusion and clonidine administration.	Norepinephrine	76-89	natriuretic peptide A	Homo sapiens	117-143
3495374-3	1987	In the present study, human CGRP I and II exerted positive inotropic effects on isolated human right auricles and relaxed small arteries from human skeletal muscle precontracted with norepinephrine (EC50 for CGRP I 0.59 nM and for CGRP II 0.37 nM).	Norepinephrine	183-197	calcitonin related polypeptide alpha	Homo sapiens	28-34
2959419-2	1987	A significant positive correlation was found between changes in circulating noradrenaline (NA) levels and changes in atrial natriuretic peptide (ANP) levels during NA infusion and clonidine administration.	Norepinephrine	76-89	natriuretic peptide A	Homo sapiens	145-148
3031526-0	1987	Noradrenaline, by activation of alpha-1-adrenoceptors in the region of the supraoptic nucleus, causes secretion of vasopressin in the unanaesthetized rat.	Norepinephrine	0-13	arginine vasopressin	Rattus norvegicus	115-126
3100285-0	1987	Norepinephrine and thyrotropin stimulation of iodide efflux in FRTL-5 thyroid cells involves metabolites of arachidonic acid and is associated with the iodination of thyroglobulin.	Norepinephrine	0-14	thyroglobulin	Rattus norvegicus	166-179
3031526-1	1987	In unanaesthetized rats chronically prepared with venous and intracerebral cannulae, noradrenaline injected into the region of the supraoptic nuclei caused a dose-dependent increase in plasma vasopressin, measured by radioimmunoassay.	Norepinephrine	85-98	arginine vasopressin	Rattus norvegicus	192-203
3031526-3	1987	The secretion of vasopressin was not secondary to change in arterial pressure, since similar injections of noradrenaline resulted in a small increase in arterial pressure, measured in the anaesthetized rat.	Norepinephrine	107-120	arginine vasopressin	Rattus norvegicus	17-28
3031526-4	1987	These results suggest that noradrenaline stimulates alpha-1-adrenoceptors, presumably located on vasopressin-secreting neurones, thereby causing these cells to secrete vasopressin into the circulation.	Norepinephrine	27-40	arginine vasopressin	Rattus norvegicus	97-108
3031526-4	1987	These results suggest that noradrenaline stimulates alpha-1-adrenoceptors, presumably located on vasopressin-secreting neurones, thereby causing these cells to secrete vasopressin into the circulation.	Norepinephrine	27-40	arginine vasopressin	Rattus norvegicus	168-179
3031526-5	1987	Tyramine injections also resulted in a prompt elevation in plasma vasopressin, indicating that endogenous noradrenaline is capable of releasing vasopressin.	Norepinephrine	106-119	arginine vasopressin	Rattus norvegicus	66-77
3031526-5	1987	Tyramine injections also resulted in a prompt elevation in plasma vasopressin, indicating that endogenous noradrenaline is capable of releasing vasopressin.	Norepinephrine	106-119	arginine vasopressin	Rattus norvegicus	144-155
3805036-2	1987	The rate of the dopamine beta-monooxygenase-catalyzed conversion of dopamine to norepinephrine is greatly stimulated by the presence of ATP, reflecting substrate hydroxylation on the ghost interior subsequent to the active transport of dopamine.	Norepinephrine	80-94	dopamine beta-hydroxylase	Bos taurus	16-43
2884573-2	1987	Both catechol oestrogens, 2-hydroxyoestradiol (2OHE2) and 2-hydroxyoesterone (2OHE1), inhibited TH activity in mesenteric artery and vas deferens in a concentration-dependent manner with potencies that were higher than those for noradrenaline but lower than that for dopamine.	Norepinephrine	229-242	LOC100008895	Oryctolagus cuniculus	96-98
3567458-2	1987	Injection of 2 ng AVP into the NTS significantly increased MAP but not plasma catecholamine concentrations, while injection of 10 ng AVP significantly increased MAP and plasma noradrenaline and adrenaline levels.	Norepinephrine	176-189	arginine vasopressin	Rattus norvegicus	133-136
3575603-9	1987	The influence of isoproterenol on affect and reactivity might reflect the physiologic action of a beta 2-adrenergic positive feedback loop which increases release of endogenous norepinephrine, and/or potentiating effects of emotion on reactivity to stress.	Norepinephrine	177-191	amyloid beta precursor protein	Homo sapiens	96-102
3032658-2	1987	The normal increase in neocortical beta 1-adrenoceptor binding caused by noradrenaline depletion was effectively prevented by ECS.	Norepinephrine	73-86	adrenoceptor beta 1	Rattus norvegicus	35-54
3102665-8	1987	Comparison of these results with those obtained previously in the rat suggests that species differences in the effects of prolactin on gonadotrophin release may be related to its divergent effects on noradrenaline turnover.	Norepinephrine	200-213	prolactin	Rattus norvegicus	122-131
3822247-2	1987	NPY decreased noradrenaline turnover in the brainstem, hypothalamus, midbrain and hippocampus.	Norepinephrine	14-27	neuropeptide Y	Rattus norvegicus	0-3
3307308-8	1987	The plasma levels of free insulin, however, were elevated by approximately 20% (p less than 0.01) by metoprolol during hypoglycemia and the plasma concentrations of epinephrine, norepinephrine, growth hormone and cortisol were enhanced by the drug.	Norepinephrine	178-192	insulin	Homo sapiens	26-33
3473965-1	1987	Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine (NE), and is known to exist in two forms: soluble and membrane-bound.	Norepinephrine	72-86	dopamine beta-hydroxylase	Bos taurus	0-25
2882411-6	1987	Under the latter conditions, norepinephrine induced about twice as much increase in cyclic AMP as did isoproterenol in adult tissue.	Norepinephrine	29-43	transmembrane serine protease 5	Rattus norvegicus	91-94
3473965-1	1987	Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine (NE), and is known to exist in two forms: soluble and membrane-bound.	Norepinephrine	72-86	dopamine beta-hydroxylase	Bos taurus	27-30
3154309-3	1987	Since vascular resistance can be viewed as a net balance of offsetting vasoconstrictor and vasodilator neurohumoral forces, and since angiotensin II and norepinephrine can stimulate the synthesis of vasodilator prostaglandins that can in turn counteract peripheral vasoconstriction, we measured changes in vasoconstrictor (angiotensin II) and vasodilator (PGE2) hormones after giving different antihypertensive drugs.	Norepinephrine	153-167	angiotensinogen	Homo sapiens	323-337
2485066-4	1987	There was a slight but significant increase in plasma noradrenaline as renin became inhibited: plasma adrenaline was unchanged.	Norepinephrine	54-67	renin	Homo sapiens	71-76
3316041-4	1987	Catecholamine excretion in urine (adrenaline + noradrenaline) on average was 252.3 +/- 77.9 ng min-1 during car racing and 121.9 +/- 37.3 ng min-1 during exhaustive ergometry (n = 10).	Norepinephrine	47-60	CD59 molecule (CD59 blood group)	Homo sapiens	95-100
2436087-7	1987	These results provide evidence that [D-Arg1,D-Pro2,D-Trp7,9,Leu11]substance P releases noradrenaline from sympathetic nerves in the submucosal plexus.	Norepinephrine	87-100	arginase-1	Cavia porcellus	39-43
3659119-2	1987	Our previous experiments demonstrated that chronic ethanol treatment of rats produces tolerance to the in vitro inhibitory effects of ethanol on norepinephrine-, KCl-, and electrically evoked contractions of the vas deferens.	Norepinephrine	145-159	arginine vasopressin	Rattus norvegicus	212-215
2879289-1	1987	Tyrosine hydroxylase [TyrOHase, tyrosine 3-monooxygenase, L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (2-hydroxylating), EC 1.14.16.2] is the rate-limiting enzyme in the synthetic pathway of catecholamines and is expressed by neurons containing dopamine, norepinephrine, and epinephrine.	Norepinephrine	265-279	tyrosine hydroxylase	Homo sapiens	32-56
3316680-8	1987	These relationships suggest a direct interaction between norepinephrine release from the TH-positive nerve terminals and the lymphocytes and macrophages closely associated with them, and focuses attention on the potential neural modulation of related functions such as T and B lymphocyte entry into the spleen and antigen capture (marginal zone), antigen presentation and T cell activation (PALS), B cell activation (parafollicular zone and marginal zone), and lymphocyte egress (outer marginal zone).	Norepinephrine	57-71	tyrosine hydroxylase	Homo sapiens	89-91
3628271-0	1987	Angiotensin II induced amplification of the vasoconstrictor response to norepinephrine and clonidine.	Norepinephrine	72-86	angiotensinogen	Homo sapiens	0-14
3028554-14	1986	In the presence of threshold spasmogenic concentrations of noradrenaline, the contractile effects of angiotensin II were augmented and became comparable to those observed in rubbed preparations.	Norepinephrine	59-72	angiotensinogen	Rattus norvegicus	101-115
3028554-15	1986	In the presence of greater concentrations of noradrenaline, angiotensin II always produced an additional contraction.	Norepinephrine	45-58	angiotensinogen	Rattus norvegicus	60-74
3822118-2	1986	On histochemical grounds, the neuropeptide Y-containing cell bodies have been subdivided into two groups: those in the brain stem in which colocalization with noradrenaline and adrenaline has been demonstrated and those in other brain regions where no catecholamine coexistence is found.	Norepinephrine	159-172	neuropeptide Y	Rattus norvegicus	30-44
3023020-1	1986	Depletion of hypothalamic norepinephrine (NE) and epinephrine by administration of diethyldithiocarbamate abolished the stimulatory effects of intraventricular (IVT) angiotensin II (AII) on LH release in ovariectomized rats pretreated with estradiol and progesterone.	Norepinephrine	26-40	angiotensinogen	Rattus norvegicus	166-180
3023020-1	1986	Depletion of hypothalamic norepinephrine (NE) and epinephrine by administration of diethyldithiocarbamate abolished the stimulatory effects of intraventricular (IVT) angiotensin II (AII) on LH release in ovariectomized rats pretreated with estradiol and progesterone.	Norepinephrine	26-40	angiotensinogen	Rattus norvegicus	182-185
2432203-12	1986	The present results demonstrate that a GAL-like peptide is present in many systems containing other neuroactive compounds, including dopamine, norepinephrine, 5-HT, GABA, and vasopressin.	Norepinephrine	143-157	galanin and GMAP prepropeptide	Rattus norvegicus	39-42
3025802-3	1986	Granulocyte membrane PEMT has Km for S-adenosylmethionine of 4.4 microM and specific activity 0.54 +/- 0.51 pmol/mg protein/15 min, is inhibited by S-adenosylhomocysteine, displays optimal activity at pH 8.0-9.5, and is stimulated by isoproterenol greater than epinephrine greater than norepinephrine, but not by prostaglandin E1, serum-treated zymosan, formyl-methionyl-leucyl-phenylalanine, or adenosine 3":5" cyclic monophosphate.	Norepinephrine	286-300	phosphatidylethanolamine N-methyltransferase	Homo sapiens	21-25
3020171-1	1986	We have compared the effects of norepinephrine, forskolin, and dibutyryl cyclic AMP (Bt2cAMP) on the regulation of the cytosolic enzyme glycerol phosphate dehydrogenase (GPDH) in the C6 rat glioma cell line.	Norepinephrine	32-46	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	136-168
3780967-1	1986	The acute anti-lipolytic effect of human growth hormone (hGH) in maximally noradrenaline-stimulated intact rat adipocytes was selectively associated with increased phosphorylation of a 46 kDa plasma membrane protein which was highly enriched by hGH-Sepharose chromatography.	Norepinephrine	75-88	growth hormone 1	Homo sapiens	41-55
2879603-1	1986	A [K+]-related, Ca2+-dependent efflux of immunoreactive somatostatin (IRS) from superfused slices of rat cerebral cortex has been observed; this release paralleled the release of both [14C]noradrenaline and [14C]GABA.	Norepinephrine	189-202	somatostatin	Rattus norvegicus	56-68
3020171-1	1986	We have compared the effects of norepinephrine, forskolin, and dibutyryl cyclic AMP (Bt2cAMP) on the regulation of the cytosolic enzyme glycerol phosphate dehydrogenase (GPDH) in the C6 rat glioma cell line.	Norepinephrine	32-46	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	170-174
2947638-6	1986	The results clearly indicate that a rise in ovarian norepinephrine occurs concomitant with the preovulatory surge in prolactin and LH.	Norepinephrine	52-66	prolactin	Rattus norvegicus	117-126
3533124-1	1986	There is much animal data to suggest that angiotensin II has a regulatory role in noradrenaline release.	Norepinephrine	82-95	angiotensinogen	Homo sapiens	42-56
3100310-6	1986	Estimated whole-body clearance of noradrenaline was mean 0.80 l min-1 X M-2 (n = 6) while the pulmonary clearance amounted to 19% of this value.	Norepinephrine	34-47	CD59 molecule (CD59 blood group)	Homo sapiens	64-69
3536707-0	1986	Long term effect of noradrenaline on insulin binding to human adipose tissue "in vitro".	Norepinephrine	20-33	insulin	Homo sapiens	37-44
3020011-2	1986	The demonstration that membrane receptors for norepinephrine are coupled in a stimulatory (beta 1, beta 2) or inhibitory (alpha 2) way via nucleotide regulatory proteins to adenylate cyclase, thus increasing or decreasing the formation of the second messenger cyclic AMP, is discussed.	Norepinephrine	46-60	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	91-97
3021940-8	1986	Angiotensin II secreted from the vascular bed by the beta 2-adrenoceptor stimulation acts locally to facilitate norepinephrine release.	Norepinephrine	112-126	angiotensinogen	Homo sapiens	0-14
3024031-16	1986	Angiotensin II, synthesized in response to beta 2-adrenoceptor activation, probably stimulates angiotensin receptors on the noradrenergic nerves, leading to an increase in noradrenaline release.	Norepinephrine	172-185	angiotensinogen	Rattus norvegicus	0-14
3018160-2	1986	In the present study, the effects of norepinephrine and 3,4-dihydroxyphenylethylamine (dopamine) on angiotensin II receptor regulation in neuronal cultures from rat hypothalamus and brainstem have been examined.	Norepinephrine	37-51	angiotensinogen	Rattus norvegicus	100-114
3018160-4	1986	Saturation and Scatchard analyses revealed that the norepinephrine-induced decrease in the binding is due to a decrease in the number of angiotensin II receptors in neuronal cultures, with little effect on the receptor affinity.	Norepinephrine	52-66	angiotensinogen	Rattus norvegicus	137-151
3018160-6	1986	The downregulation of angiotensin II receptors by norepinephrine or dopamine is blocked by alpha 1-adrenergic and not by other adrenergic antagonists, a result suggesting that this effect is initiated at the cell surface involving alpha 1-adrenergic receptors.	Norepinephrine	50-64	angiotensinogen	Rattus norvegicus	22-36
3018160-8	1986	In summary, these results show that norepinephrine and dopamine are able to alter the regulation of neuronal angiotensin II receptors by acting at alpha 1-adrenergic receptors, which is a novel finding.	Norepinephrine	36-50	angiotensinogen	Rattus norvegicus	109-123
2942555-2	1986	The potential of synthetic alpha hANP to antagonize the pressor action of norepinephrine (NE) or angiotensin II (AII) and a possible influence of NE or AII pressor infusions on circulating immunoreactive ANP (irANP) were investigated in 14 normal young subjects.	Norepinephrine	74-88	natriuretic peptide A	Homo sapiens	33-37
3827993-1	1986	The present experiments were designed to investigate the effect of norepinephrine (NE) applied directly in the area of the paraventricular nucleus (PVN) of the hypothalamus on arginine-vasopressin (AVP) release and blood pressure.	Norepinephrine	67-81	arginine vasopressin	Homo sapiens	176-196
3827993-1	1986	The present experiments were designed to investigate the effect of norepinephrine (NE) applied directly in the area of the paraventricular nucleus (PVN) of the hypothalamus on arginine-vasopressin (AVP) release and blood pressure.	Norepinephrine	67-81	arginine vasopressin	Homo sapiens	198-201
3017854-0	1986	Vascular responses to ouabain and norepinephrine in low and normal renin hypertension.	Norepinephrine	34-48	renin	Homo sapiens	67-72
2942555-2	1986	The potential of synthetic alpha hANP to antagonize the pressor action of norepinephrine (NE) or angiotensin II (AII) and a possible influence of NE or AII pressor infusions on circulating immunoreactive ANP (irANP) were investigated in 14 normal young subjects.	Norepinephrine	74-88	natriuretic peptide A	Homo sapiens	34-37
2875902-1	1986	Oxytocin, vasopressin, melanostatin, bradykinin, LHRH-like peptide in different ways affected the spontaneous outflow and release of adrenaline and noradrenaline induced with central and peripheral nervous stimuli as well as with acetylcholine in the superfusate of the dog isolated inferior mesenteric ganglion.	Norepinephrine	148-161	kininogen 1	Canis lupus familiaris	37-47
2879293-7	1986	noradrenaline (5 micrograms/kg), adrenaline (5 micrograms/kg) and phenylephrine (20 micrograms/kg) were markedly inhibited (60-75%) by benoxathian (100 micrograms/kg) whilst the pressor response to angiotensin II (0.05 micrograms/kg) was not reduced, but indeed slightly increased.	Norepinephrine	0-13	angiotensinogen	Rattus norvegicus	198-212
3025824-4	1986	The stimulation-evoked overflow of NPY-LI from the heart was enhanced about 3-fold by alpha-adrenoceptor blockade using phenoxybenzamine, suggesting that NPY release is under prejunctional inhibitory control by noradrenaline (NA).	Norepinephrine	211-224	neuropeptide Y	Sus scrofa	35-38
3025824-4	1986	The stimulation-evoked overflow of NPY-LI from the heart was enhanced about 3-fold by alpha-adrenoceptor blockade using phenoxybenzamine, suggesting that NPY release is under prejunctional inhibitory control by noradrenaline (NA).	Norepinephrine	211-224	neuropeptide Y	Sus scrofa	154-157
2942391-2	1986	An injection of synthetic human beta-endorphin (20 micrograms/kg BW) into a cephalic vein produced a significant rise in the portal concentration of dopamine, norepinephrine, and epinephrine.	Norepinephrine	159-173	proopiomelanocortin	Homo sapiens	32-46
2875048-4	1986	In drug-treated mice, enzymatic activity for TOH as well as the total concentration of enzyme was significantly increased in the locus coeruleus (LC), a principal norepinephrine-containing nucleus of the brainstem, but not in other brain regions.	Norepinephrine	163-177	tyrosine hydroxylase	Homo sapiens	45-48
3530932-9	1986	The responses of prolactin (2P less than 0.02), norepinephrine (2P less than 0.02), cortisol, and growth hormone were attenuated following proinsulin.	Norepinephrine	48-62	insulin	Homo sapiens	139-149
3711722-9	1986	Myocardial catecholamines were also determined in 14 subjects; a weak correlation (r = 0.57, P less than 0.05) between the tissue concentrations of VIP and norepinephrine was noted.	Norepinephrine	156-170	vasoactive intestinal peptide	Homo sapiens	148-151
3015341-1	1986	The size of miniature end-plate potentials (m.e.p.p.s) and miniature end-plate currents (m.e.p.c.s) at frog neuromuscular junctions was increased by a factor of two or more following treatment with norepinephrine, epinephrine, a cAMP derivative, insulin or ACTH.	Norepinephrine	198-212	insulin	Homo sapiens	246-253
3015452-1	1986	Previous studies have demonstrated that pretreatment with mannitol, furosemide, or bradykinin can attenuate the severity of norepinephrine-induced renal functional impairment.	Norepinephrine	124-138	kininogen 1	Canis lupus familiaris	83-93
3015341-1	1986	The size of miniature end-plate potentials (m.e.p.p.s) and miniature end-plate currents (m.e.p.c.s) at frog neuromuscular junctions was increased by a factor of two or more following treatment with norepinephrine, epinephrine, a cAMP derivative, insulin or ACTH.	Norepinephrine	198-212	proopiomelanocortin	Homo sapiens	257-261
2873056-1	1986	An antiserum to dopamine-beta-hydroxylase purified from bovine adrenal medulla, acting in the presence of complement, caused the release of 12% of lactate dehydrogenase, 20% of tyrosine hydroxylase activity, and 40% of noradrenaline (NA) content from synaptosomes prepared from rat brain cerebral cortex.	Norepinephrine	219-232	dopamine beta-hydroxylase	Bos taurus	16-41
2873536-5	1986	NPY-LI coexists mainly with noradrenaline in sympathetic neurons, and may have regulatory functions in sympathetic ganglia and in target organs.	Norepinephrine	28-41	neuropeptide Y	Rattus norvegicus	0-3
2940358-8	1986	administration of norepinephrine with beta-endorphin blunted the plasma epinephrine response to i.c.	Norepinephrine	18-32	proopiomelanocortin	Homo sapiens	38-52
2872078-0	1986	"Neuropeptide tyrosine" (NPY) is co-stored with noradrenaline in vascular but not in parenchymal sympathetic nerves of brown adipose tissue.	Norepinephrine	48-61	neuropeptide Y	Rattus norvegicus	25-28
2940358-15	1986	norepinephrine on beta-endorphin-induced catecholamine secretion.	Norepinephrine	0-14	proopiomelanocortin	Homo sapiens	18-32
2940358-17	1986	norepinephrine at a dose insufficient to reduce beta-endorphin-induced catecholamine secretion in vehicle-treated rats prevented beta-endorphin-induced epinephrine and norepinephrine secretion in rats whose brains had been depleted of norepinephrine by prior 6-OHDA treatment.	Norepinephrine	0-14	proopiomelanocortin	Homo sapiens	48-62
2940358-17	1986	norepinephrine at a dose insufficient to reduce beta-endorphin-induced catecholamine secretion in vehicle-treated rats prevented beta-endorphin-induced epinephrine and norepinephrine secretion in rats whose brains had been depleted of norepinephrine by prior 6-OHDA treatment.	Norepinephrine	0-14	proopiomelanocortin	Homo sapiens	129-143
3698518-4	1986	As observed with aggregation, 0.3 unit of thrombin/ml produced a more marked effect on release than ADP, noradrenaline and adrenaline being increased by 570% and 169% respectively.	Norepinephrine	105-118	coagulation factor II, thrombin	Homo sapiens	42-50
2940358-17	1986	norepinephrine at a dose insufficient to reduce beta-endorphin-induced catecholamine secretion in vehicle-treated rats prevented beta-endorphin-induced epinephrine and norepinephrine secretion in rats whose brains had been depleted of norepinephrine by prior 6-OHDA treatment.	Norepinephrine	168-182	proopiomelanocortin	Homo sapiens	48-62
2940358-17	1986	norepinephrine at a dose insufficient to reduce beta-endorphin-induced catecholamine secretion in vehicle-treated rats prevented beta-endorphin-induced epinephrine and norepinephrine secretion in rats whose brains had been depleted of norepinephrine by prior 6-OHDA treatment.	Norepinephrine	168-182	proopiomelanocortin	Homo sapiens	129-143
2940358-17	1986	norepinephrine at a dose insufficient to reduce beta-endorphin-induced catecholamine secretion in vehicle-treated rats prevented beta-endorphin-induced epinephrine and norepinephrine secretion in rats whose brains had been depleted of norepinephrine by prior 6-OHDA treatment.	Norepinephrine	168-182	proopiomelanocortin	Homo sapiens	48-62
2940358-17	1986	norepinephrine at a dose insufficient to reduce beta-endorphin-induced catecholamine secretion in vehicle-treated rats prevented beta-endorphin-induced epinephrine and norepinephrine secretion in rats whose brains had been depleted of norepinephrine by prior 6-OHDA treatment.	Norepinephrine	168-182	proopiomelanocortin	Homo sapiens	129-143
3706534-0	1986	Synergistic action of angiotensin II on norepinephrine-induced prostaglandin release from rat glomeruli.	Norepinephrine	40-54	angiotensinogen	Rattus norvegicus	22-36
3706534-3	1986	Norepinephrine (NE) stimulated PGE2 (from 2,117 +/- 117 to 3,968 +/- 182 pg X mg protein-1 X 60 min-1, P less than 0.01) at a concentration of 10(-4)M and PGF2 alpha (from 2,748 +/- 285 to 8,535 +/- 495 pg X mg protein-1 X 60 min-1, P less than 0.01) at a concentration of 10(-5)M. However, neither angiotensin II (ANG II) nor arginine vasopressin (AVP) affected the release of PG and TXB2 at concentrations up to 10(-5)M. In the presence of 10(-5) M NE, ANG II enhanced the release of PGE2 (from 3,307 +/- 207 to 6,865 +/- 469 pg X mg protein-1 X 60 min-1., P less than 0.01) and PGF2 alpha (from 3,652 +/- 252 to 6,612 +/- 388 pg X mg protein-1 X 60 min-1, P less than 0.01) at a concentration of 10(-8)M, whereas AVP lacked any similar effect.	Norepinephrine	0-14	angiotensinogen	Rattus norvegicus	299-313
3706534-3	1986	Norepinephrine (NE) stimulated PGE2 (from 2,117 +/- 117 to 3,968 +/- 182 pg X mg protein-1 X 60 min-1, P less than 0.01) at a concentration of 10(-4)M and PGF2 alpha (from 2,748 +/- 285 to 8,535 +/- 495 pg X mg protein-1 X 60 min-1, P less than 0.01) at a concentration of 10(-5)M. However, neither angiotensin II (ANG II) nor arginine vasopressin (AVP) affected the release of PG and TXB2 at concentrations up to 10(-5)M. In the presence of 10(-5) M NE, ANG II enhanced the release of PGE2 (from 3,307 +/- 207 to 6,865 +/- 469 pg X mg protein-1 X 60 min-1., P less than 0.01) and PGF2 alpha (from 3,652 +/- 252 to 6,612 +/- 388 pg X mg protein-1 X 60 min-1, P less than 0.01) at a concentration of 10(-8)M, whereas AVP lacked any similar effect.	Norepinephrine	0-14	angiotensinogen	Rattus norvegicus	315-321
3706534-3	1986	Norepinephrine (NE) stimulated PGE2 (from 2,117 +/- 117 to 3,968 +/- 182 pg X mg protein-1 X 60 min-1, P less than 0.01) at a concentration of 10(-4)M and PGF2 alpha (from 2,748 +/- 285 to 8,535 +/- 495 pg X mg protein-1 X 60 min-1, P less than 0.01) at a concentration of 10(-5)M. However, neither angiotensin II (ANG II) nor arginine vasopressin (AVP) affected the release of PG and TXB2 at concentrations up to 10(-5)M. In the presence of 10(-5) M NE, ANG II enhanced the release of PGE2 (from 3,307 +/- 207 to 6,865 +/- 469 pg X mg protein-1 X 60 min-1., P less than 0.01) and PGF2 alpha (from 3,652 +/- 252 to 6,612 +/- 388 pg X mg protein-1 X 60 min-1, P less than 0.01) at a concentration of 10(-8)M, whereas AVP lacked any similar effect.	Norepinephrine	0-14	arginine vasopressin	Rattus norvegicus	336-347
3706534-3	1986	Norepinephrine (NE) stimulated PGE2 (from 2,117 +/- 117 to 3,968 +/- 182 pg X mg protein-1 X 60 min-1, P less than 0.01) at a concentration of 10(-4)M and PGF2 alpha (from 2,748 +/- 285 to 8,535 +/- 495 pg X mg protein-1 X 60 min-1, P less than 0.01) at a concentration of 10(-5)M. However, neither angiotensin II (ANG II) nor arginine vasopressin (AVP) affected the release of PG and TXB2 at concentrations up to 10(-5)M. In the presence of 10(-5) M NE, ANG II enhanced the release of PGE2 (from 3,307 +/- 207 to 6,865 +/- 469 pg X mg protein-1 X 60 min-1., P less than 0.01) and PGF2 alpha (from 3,652 +/- 252 to 6,612 +/- 388 pg X mg protein-1 X 60 min-1, P less than 0.01) at a concentration of 10(-8)M, whereas AVP lacked any similar effect.	Norepinephrine	0-14	angiotensinogen	Rattus norvegicus	455-461
3698518-5	1986	Values for platelet noradrenaline content were found to mirror those for the release from platelets induced by thrombin.	Norepinephrine	20-33	coagulation factor II, thrombin	Homo sapiens	111-119
3702592-2	1986	Norepinephrine released from sympathetic nerve endings within the pineal gland stimulates NAT activity and, therefore, melatonin synthesis.	Norepinephrine	0-14	N-acetyltransferase 1	Rattus norvegicus	90-93
3534807-6	1986	At 6 hours of incubation, VIP stimulated total catecholamine release from fetal adrenomedullary cells in a dose-dependent manner at concentrations ranging from 10(-8) to 10(-4) M. The release of norepinephrine and epinephrine, but not dopamine, was significantly enhanced.	Norepinephrine	195-209	vasoactive intestinal peptide	Homo sapiens	26-29
3012417-1	1986	Norepinephrine and the alpha-agonist phenylephrine in concentrations of 10(-5) to 10(-3) M prompted the release of radioimmunoassayable vasopressin (up to 150 pg/min) and oxytocin (up to 20 pg/min) from intraarterially perfused explants of rat basal forebrain.	Norepinephrine	0-14	arginine vasopressin	Rattus norvegicus	136-147
3514728-8	1986	Norepinephrine levels were elevated in all patients (694 +/- 110 pg/ml) and correlated with baseline stroke volume index (r = 0.75, p less than 0.025) and plasma renin activity (r = 0.67, p less than 0.05).	Norepinephrine	0-14	renin	Homo sapiens	162-167
3486086-4	1986	hCGRP (545 pmol/min) caused the diastolic pressure to fall from 64 +/- 5 to 55 +/- 7 mmHg (P less than 0.05), the heart rate to increase from 61 +/- 7 to 87 +/- 5 beats/min (P less than 0.05) and the skin temperature to increase from 33.7 +/- 0.9 to 34.9 +/- 0.5 degrees C. Plasma noradrenaline increased from 481 +/- 126 to 835 +/- 65 pg/ml (P less than 0.05) and plasma adrenaline from 57 +/- 17 to 82 +/- 12 pg/ml (P less than 0.05).	Norepinephrine	281-294	calcitonin related polypeptide alpha	Homo sapiens	0-5
3715154-0	1986	Noradrenaline as a possible mediator of angiotensin II induced fluid transport in rat ileum in vitro.	Norepinephrine	0-13	angiotensinogen	Rattus norvegicus	40-54
3006688-1	1986	In cultured rat arterial smooth muscle cells treated with quin 2, cytosolic Ca2+ transients induced by norepinephrine were recorded microfluorometrically.	Norepinephrine	103-117	carbonic anhydrase 2	Rattus norvegicus	76-79
3006688-2	1986	In the presence or absence of extracellular Ca2+, norepinephrine induced transient and dose-dependent elevations in cytosolic Ca2+, with a similar time course, the peak levels being observed at 2 min.	Norepinephrine	50-64	carbonic anhydrase 2	Rattus norvegicus	44-47
3006688-2	1986	In the presence or absence of extracellular Ca2+, norepinephrine induced transient and dose-dependent elevations in cytosolic Ca2+, with a similar time course, the peak levels being observed at 2 min.	Norepinephrine	50-64	carbonic anhydrase 2	Rattus norvegicus	126-129
3006688-4	1986	We propose that with or without extracellular Ca2+, norepinephrine activates mainly alpha-1 adrenoceptors leading to a release of Ca2+ from intracellular stores.	Norepinephrine	52-66	carbonic anhydrase 2	Rattus norvegicus	46-49
3006688-4	1986	We propose that with or without extracellular Ca2+, norepinephrine activates mainly alpha-1 adrenoceptors leading to a release of Ca2+ from intracellular stores.	Norepinephrine	52-66	carbonic anhydrase 2	Rattus norvegicus	130-133
3949732-1	1986	Adrenal chromaffin granules must shuttle reducing equivalents from the cytosol inward to reduce ascorbic acid oxidized during norepinephrine biosynthesis by intragranular dopamine-beta-hydroxylase.	Norepinephrine	126-140	dopamine beta-hydroxylase	Bos taurus	171-196
3010640-2	1986	The 10(-9)M NPY enhanced (about two-fold) the contractile responses to transmural nerve stimulation (TNS), noradrenaline (NA) and adrenaline (about two-fold) in the femoral artery.	Norepinephrine	107-120	neuropeptide Y	Rattus norvegicus	12-15
3513605-0	1986	Angiotensin II stimulates norepinephrine uptake in hypothalamus-brain stem neuronal cultures.	Norepinephrine	26-40	angiotensinogen	Rattus norvegicus	0-14
3010387-6	1986	Thirdly, NPY and PYY act prejunctionally in that they suppress the release of noradrenaline from sympathetic nerve endings upon stimulation; this was studied in the rat vas deferens.	Norepinephrine	78-91	neuropeptide Y	Rattus norvegicus	9-12
3951237-1	1986	An improved method is described for the measurement of dopamine-beta-hydroxylase (D beta H) activity in cerebrospinal fluid, which is based on an incubation with dopamine at a saturated substrate concentration and quantitation of the reaction product noradrenaline, by high-performance liquid chromatography with electrochemical detection using 3,4-dihydroxynorephedrine as internal standard.	Norepinephrine	251-264	dopamine beta-hydroxylase	Oryctolagus cuniculus	55-80
3703019-0	1986	Sodium-dependence of the saturability of carrier-mediated noradrenaline efflux from noradrenergic neurones in the rat vas deferens.	Norepinephrine	58-71	arginine vasopressin	Rattus norvegicus	118-121
3535395-3	1986	Arterial plasma vasopressin decreased by 3.4 +/- 1.7 ng/l (0.05 less than p less than 0.10) and urinary excretion of vasopressin was reduced by nearly 50% (p less than 0.001) during sodium depletion, while plasma noradrenaline increased by 38% (p less than 0.001) and plasma dopamine showed an increase by 58% (p less than 0.001).	Norepinephrine	213-226	arginine vasopressin	Homo sapiens	117-128
3010387-10	1986	The NPY- and PYY-induced suppression of noradrenaline release from the prostatic portion of the rat vas deferens was reproduced by PYY 13-36 but not by the shorter fragments nor by desamido-NPY.	Norepinephrine	40-53	neuropeptide Y	Rattus norvegicus	4-7
2427848-4	1986	For a drug which simultaneously blocks alpha 2- and beta 1-adrenoceptors the following effects may be anticipated: all cardiac changes usually induced by beta 1-blockade (reduced heart rate, contractility and A-V conduction); vasodilatation induced by postsynaptic alpha 2-adrenoceptor blockade; enhanced release of presynaptic noradrenaline, owing to presynaptic alpha 2-receptor blockade.	Norepinephrine	328-341	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	39-58
2867688-2	1986	The modulation of cortical VIP release by several neurotransmitters [gamma-aminobutyric acid (GABA), opioids, norepinephrine, acetylcholine, and glutamate] normally present in the cerebral cortex was studied by administering respective agonists and antagonists for their receptors.	Norepinephrine	110-124	vasoactive intestinal peptide	Homo sapiens	27-30
3946504-7	1986	A significant positive correlation between the content of norepinephrine and C-peptide was found in control women (r = 0.57; p less than 0.05) and in women with gestational diabetes (r = 0.75; p less than 0.05).	Norepinephrine	58-72	insulin	Homo sapiens	77-86
3708916-7	1986	It is concluded that lowering the bath temperature enhances the contractility of the vas deferens in response to the release of neurotransmitters and to the application of exogenous noradrenaline via a postsynaptic action.	Norepinephrine	182-195	arginine vasopressin	Rattus norvegicus	85-88
3000912-0	1986	ACTH stimulation of adrenal epinephrine and norepinephrine release.	Norepinephrine	44-58	proopiomelanocortin	Homo sapiens	0-4
2427848-4	1986	For a drug which simultaneously blocks alpha 2- and beta 1-adrenoceptors the following effects may be anticipated: all cardiac changes usually induced by beta 1-blockade (reduced heart rate, contractility and A-V conduction); vasodilatation induced by postsynaptic alpha 2-adrenoceptor blockade; enhanced release of presynaptic noradrenaline, owing to presynaptic alpha 2-receptor blockade.	Norepinephrine	328-341	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	52-58
3783148-4	1986	The results may indicate the existence of a presynaptic NPY receptor on the noradrenaline and/or adrenaline nerve terminals, which may enhance the presynaptic alpha 2-adrenoreceptor function to inhibit 3H-NA release.	Norepinephrine	76-89	neuropeptide Y	Rattus norvegicus	56-59
3001183-4	1986	Norepinephrine and epinephrine blocked the capacity of recombinant interferon-gamma (IFN-gamma) to activate murine macrophages to a cytotoxic state capable of selectively killing HSV-infected cells.	Norepinephrine	0-14	interferon gamma	Mus musculus	67-83
3018392-3	1986	In sympathetic postganglionic neurons, NPY coexists with noradrenaline.	Norepinephrine	57-70	neuropeptide Y	Rattus norvegicus	39-42
3001183-4	1986	Norepinephrine and epinephrine blocked the capacity of recombinant interferon-gamma (IFN-gamma) to activate murine macrophages to a cytotoxic state capable of selectively killing HSV-infected cells.	Norepinephrine	0-14	interferon gamma	Mus musculus	85-94
3018392-7	1986	Thirdly, NPY acts prejunctionally in that it suppresses the release of noradrenaline from sympathetic nerve terminals; this was studied in the rat vas deferens.	Norepinephrine	71-84	neuropeptide Y	Rattus norvegicus	9-12
3736783-1	1986	A subpopulation of norepinephrine-containing cells in the cat adrenal medulla contain neurotensin (NT) immunoreactive material.	Norepinephrine	19-33	neurotensin	Felis catus	86-97
3703161-2	1986	Norepinephrine (10 micrograms) and the alpha-1 agonist, phenylephrine (50 micrograms), administered intracerebroventricularly resulted in significant increases in the plasma vasopressin concentration and blood pressure.	Norepinephrine	0-14	arginine vasopressin	Rattus norvegicus	174-185
3736783-1	1986	A subpopulation of norepinephrine-containing cells in the cat adrenal medulla contain neurotensin (NT) immunoreactive material.	Norepinephrine	19-33	neurotensin	Felis catus	99-101
20493065-6	1986	From studies on the pattern of terminal distribution results have been obtained compatible with the view that neuropeptide Y or a neuropeptide Y related peptide can be a comodulator in noradrenaline and adrenaline nerve terminal networks of these regions.	Norepinephrine	185-198	neuropeptide Y	Rattus norvegicus	110-124
20493065-6	1986	From studies on the pattern of terminal distribution results have been obtained compatible with the view that neuropeptide Y or a neuropeptide Y related peptide can be a comodulator in noradrenaline and adrenaline nerve terminal networks of these regions.	Norepinephrine	185-198	neuropeptide Y	Rattus norvegicus	130-144
20493065-14	1986	In addition, it is suggested that the ability of neuropeptide Y to increase adrenocorticotrophin and corticosterone secretion is at least in part related to its ability to reduce noradrenaline turnover in the parvocellular part of the paraventricular hypothalamic nucleus, rich in corticotrophin releasing factor immunoreactive nerve cell bodies.	Norepinephrine	179-192	neuropeptide Y	Rattus norvegicus	49-63
20493065-15	1986	It is speculated that neuropeptide Y as a comodulator in the noradrenaline nerve terminals in this area may enhance the excitatory actions of noradrenaline on the corticotrophin releasing factor immunoreactive nerve cells.	Norepinephrine	61-74	neuropeptide Y	Rattus norvegicus	22-36
3534860-7	1986	The following sympathetic components may contribute to the effect of angiotensin II:ganglionic stimulation; enhanced release of noradrenaline (tyramine-like effect); inhibited noradrenaline re-uptake; facilitation of noradrenaline release via presynaptic AII-receptors; sensitization of postsynaptic alpha-adrenoceptors.	Norepinephrine	128-141	angiotensinogen	Homo sapiens	69-83
2875443-9	1986	Furthermore, VIP interacts synergistically with norepinephrine to stimulate cAMP formation and to inhibit the firing rate of spontaneously active identified cortical neurons.	Norepinephrine	48-62	vasoactive intestinal peptide	Homo sapiens	13-16
3031716-17	1986	The results indicate that the GH-stimulating effect of DMI is primarily related to the ability of DMI to inhibit noradrenaline (NA) reuptake.	Norepinephrine	113-126	growth hormone 1	Homo sapiens	30-32
3031718-16	1986	The findings of these trials, especially those of the prazosin trial, indicate that DMI-induced stimulation of cortisol and ACTH secretion is attributable to the noradrenaline (NA) reuptake inhibiting effect of DMI, and that the stimulus is transmitted with the aid of noradrenergic alpha-1 receptors.	Norepinephrine	162-175	proopiomelanocortin	Homo sapiens	124-128
3534860-7	1986	The following sympathetic components may contribute to the effect of angiotensin II:ganglionic stimulation; enhanced release of noradrenaline (tyramine-like effect); inhibited noradrenaline re-uptake; facilitation of noradrenaline release via presynaptic AII-receptors; sensitization of postsynaptic alpha-adrenoceptors.	Norepinephrine	176-189	angiotensinogen	Homo sapiens	69-83
3534860-7	1986	The following sympathetic components may contribute to the effect of angiotensin II:ganglionic stimulation; enhanced release of noradrenaline (tyramine-like effect); inhibited noradrenaline re-uptake; facilitation of noradrenaline release via presynaptic AII-receptors; sensitization of postsynaptic alpha-adrenoceptors.	Norepinephrine	176-189	angiotensinogen	Homo sapiens	69-83
3841386-0	1985	Comparison between the actions of avian pancreatic polypeptide, neuropeptide Y and norepinephrine on the excitability of rat supraoptic vasopressin neurons.	Norepinephrine	83-97	arginine vasopressin	Rattus norvegicus	136-147
3841386-1	1985	Effects of pressure-applied avian pancreatic polypeptide (APP), neuropeptide Y (NPY) and norepinephrine (NE) on the activity of putative vasopressin-synthesizing neurosecretory cells of the supraoptic nucleus were studied in pentobarbitone-anesthetized male rats.	Norepinephrine	89-103	arginine vasopressin	Rattus norvegicus	137-148
3907740-0	1985	Dietary and pharmacological alterations in endogenous angiotensin II: effect on noradrenaline pressor responsiveness in the rat.	Norepinephrine	80-93	angiotensinogen	Rattus norvegicus	54-68
3000512-0	1985	Opposing alpha- and beta-adrenergic mechanisms mediate dose-dependent actions of noradrenaline on supraoptic vasopressin neurones in vivo.	Norepinephrine	81-94	arginine vasopressin	Rattus norvegicus	109-120
2856713-9	1985	Angiotensin II contributes to the vasoconstrictive ability of the sympathetic nervous system, either through a direct vascular action or by enhancing the vascular responsiveness to noradrenaline stimulation.	Norepinephrine	181-194	angiotensinogen	Homo sapiens	0-14
3910726-4	1985	There was a slight but significant increase in plasma noradrenaline as renin became inhibited; plasma adrenaline was unchanged.	Norepinephrine	54-67	renin	Homo sapiens	71-76
3866254-0	1985	Vasoactive intestinal polypeptide acts synergistically with norepinephrine to depress spontaneous discharge rate in cerebral cortical neurons.	Norepinephrine	60-74	vasoactive intestinal peptide	Rattus norvegicus	0-33
3908322-4	1985	Although the release of norepinephrine is stimulated by insulin, a norepinephrine-mediated pressor effect is prevented in healthy men by a simultaneous norepinephrine-antagonistic action of insulin.	Norepinephrine	24-38	insulin	Homo sapiens	56-63
3908322-4	1985	Although the release of norepinephrine is stimulated by insulin, a norepinephrine-mediated pressor effect is prevented in healthy men by a simultaneous norepinephrine-antagonistic action of insulin.	Norepinephrine	67-81	insulin	Homo sapiens	190-197
3908322-4	1985	Although the release of norepinephrine is stimulated by insulin, a norepinephrine-mediated pressor effect is prevented in healthy men by a simultaneous norepinephrine-antagonistic action of insulin.	Norepinephrine	67-81	insulin	Homo sapiens	190-197
4087976-1	1985	In vas deferens from acute and chronic diabetic rats a hypersensitivity to norepinephrine and acetylcholine was observed.	Norepinephrine	75-89	arginine vasopressin	Rattus norvegicus	3-6
4091266-3	1985	Purified AADC showed a single band with an Mr of 50,000 on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and decarboxylated L-3,4-dihydroxyphenylalanine, L-5-hydroxytryptophan, and L-threo-3,4-dihydroxyphenylserine (a synthetic precursor of natural norepinephrine).	Norepinephrine	262-276	dopa decarboxylase	Homo sapiens	9-13
3914638-5	1985	It was also demonstrated, using correlative light microscopic immunostaining on serial sections and double electron microscopic immunocytochemistry, that C-PON and NPY immunoreactivities are co-localized in neuronal cell bodies of the brain cortex, sympathetic ganglion cells, norepinephrine-containing granules of the adrenal medulla and in human pheochromocytoma tumor cells.	Norepinephrine	277-291	paraoxonase 1	Homo sapiens	156-159
3932336-1	1985	Ascorbic acid donates electrons to dopamine beta-monooxygenase during the hydroxylation of dopamine to norepinephrine in vitro.	Norepinephrine	103-117	dopamine beta-hydroxylase	Bos taurus	35-62
3929859-4	1985	Bradykinin is 1,000-fold more potent than the other agonists tested, which include histamine, norepinephrine, epinephrine, eledoisin-related peptide, arginine-vasopressin, lysine-vasopressin, desmopressin acetate, carbachol, and acetylcholine.	Norepinephrine	94-108	kininogen 1	Homo sapiens	0-10
3938249-7	1985	At variance with primary hypertensive and normal volunteers, renin was tightly correlated with noradrenaline in patients with phaeochromocytoma (r" = .54, r" = .60, and r" = .74 in supine position, after standing and after walking 1 h, p less than .01).	Norepinephrine	95-108	renin	Homo sapiens	61-66
2416014-0	1985	Galanin potentiates electrical stimulation and exogenous norepinephrine-induced contractions in the rat vas deferens.	Norepinephrine	57-71	galanin and GMAP prepropeptide	Rattus norvegicus	0-7
3900340-8	1985	The results obtained with nerve stimulation and norepinephrine indicate that endogenous angiotensin II selectively interacted with sympathetic neural control of vascular resistance, whereas cardiac responsiveness to noradrenergic neurons was not altered.	Norepinephrine	48-62	angiotensinogen	Rattus norvegicus	88-102
2863199-3	1985	Infusion of noradrenaline, an alpha-adrenergic agonist, inhibited basal and vasoactive intestinal polypeptide (VIP) stimulated flow rate and output of EGF from Brunner"s glands and increased the amount of EGF in the tissue.	Norepinephrine	12-25	vasoactive intestinal peptide	Rattus norvegicus	76-109
2863199-3	1985	Infusion of noradrenaline, an alpha-adrenergic agonist, inhibited basal and vasoactive intestinal polypeptide (VIP) stimulated flow rate and output of EGF from Brunner"s glands and increased the amount of EGF in the tissue.	Norepinephrine	12-25	vasoactive intestinal peptide	Rattus norvegicus	111-114
2863199-6	1985	The presence of PAS-positive mucus in Brunner"s glands was unchanged during infusion of noradrenaline whereas VIP induced a depletion of Brunner"s gland mucus which in turn was prevented by simultaneous infusion of noradrenaline.	Norepinephrine	215-228	vasoactive intestinal peptide	Rattus norvegicus	110-113
4068381-1	1985	Organ culture of rat vas deferens produced supersensitivity to norepinephrine and acetylcholine in contractile response without change in alpha 1-adrenergic and muscarinic acetylcholine receptors.	Norepinephrine	63-77	arginine vasopressin	Rattus norvegicus	21-24
2997630-0	1985	Involvement of cAMP in modulation of noradrenaline release in the human pulmonary artery.	Norepinephrine	37-50	cathelicidin antimicrobial peptide	Homo sapiens	15-19
2997630-4	1985	It is concluded that cAMP plays a role in the modulation of noradrenaline release in the human pulmonary artery and that presynaptic beta-adrenoceptors appear to be coupled to an adenylate cyclase in the sympathetic nerve terminals.	Norepinephrine	60-73	cathelicidin antimicrobial peptide	Homo sapiens	21-25
2413714-1	1985	The effects of acetylcholine, substance P and vasoactive intestinal polypeptide (VIP) on the endogenous noradrenaline (NA) overflow were compared to those of two other vasodilators, nitroglycerin and felodipine, neither of which are thought to influence NA neurotransmission in blood perfused skeletal muscle.	Norepinephrine	104-117	vasoactive intestinal peptide	Canis lupus familiaris	46-79
2991741-0	1985	The relationships between receptor binding capacity for norepinephrine, angiotensin II, and vasopressin and release of inositol trisphosphate, Ca2+ mobilization, and phosphorylase activation in rat liver.	Norepinephrine	56-70	arginine vasopressin	Rattus norvegicus	92-103
2413714-1	1985	The effects of acetylcholine, substance P and vasoactive intestinal polypeptide (VIP) on the endogenous noradrenaline (NA) overflow were compared to those of two other vasodilators, nitroglycerin and felodipine, neither of which are thought to influence NA neurotransmission in blood perfused skeletal muscle.	Norepinephrine	104-117	vasoactive intestinal peptide	Canis lupus familiaris	81-84
4024851-0	1985	The vasopressin response to microinjections of norepinephrine into the brain of the conscious pig.	Norepinephrine	47-61	vasopressin	Sus scrofa	4-15
4024851-6	1985	Injections of norepinephrine in the dose range 10(-4)-10(-10) M had no effect in the male animal but a significant vasopressin response could be obtained in the females.	Norepinephrine	14-28	vasopressin	Sus scrofa	115-126
3834919-0	1985	Depletion of brain norepinephrine with DSP-4 does not alter acquisition or performance of a radial-arm maze task.	Norepinephrine	19-33	dual specificity phosphatase 26	Homo sapiens	39-44
3834919-3	1985	Neurochemical analysis performed 90 days after injection revealed that DSP-4 significantly decreased concentrations of norepinephrine in the hippocampus, cortex, and cerebellum.	Norepinephrine	119-133	dual specificity phosphatase 26	Homo sapiens	71-76
2861137-0	1985	Neuropeptide Y-like immunoreactive structures in the rat stomach with special reference to the noradrenaline neuron system.	Norepinephrine	95-108	neuropeptide Y	Rattus norvegicus	0-14
3893156-4	1985	The stimulation of jejunal absorption in response to ANG II is secondary to the release of norepinephrine (NE) from enteric sympathetic nerves.	Norepinephrine	91-105	angiotensinogen	Homo sapiens	53-59
2582037-4	1985	Adrenocorticotropin and noradrenaline each completely blocked the capacity of mouse recombinant interferon-gamma (INF-gamma) to activate murine peritoneal macrophages to a tumoricidal state as measured by the lysis of 125I-UdR-labeled melanoma target cells.	Norepinephrine	24-37	interferon gamma	Mus musculus	96-112
4040140-6	1985	Both PBTX and norepinephrine contracted rat vas deferens.	Norepinephrine	14-28	arginine vasopressin	Rattus norvegicus	44-47
2582037-4	1985	Adrenocorticotropin and noradrenaline each completely blocked the capacity of mouse recombinant interferon-gamma (INF-gamma) to activate murine peritoneal macrophages to a tumoricidal state as measured by the lysis of 125I-UdR-labeled melanoma target cells.	Norepinephrine	24-37	interferon gamma	Mus musculus	114-123
2415954-3	1985	Vasoactive intestinal peptide (VIP) increases cellular cAMP levels in human thyroid cultures and its effect is additive to increases produced by norepinephrine (NE) and isoproterenol (ISO).	Norepinephrine	145-159	vasoactive intestinal peptide	Homo sapiens	31-34
3926960-0	1985	DSP-4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine) depletes noradrenaline in kitten visual cortex without altering the effects of monocular deprivation.	Norepinephrine	62-75	dual specificity phosphatase 26	Homo sapiens	0-5
4046321-0	1985	Evidence for a role of PTH in the reduced pressor response to norepinephrine in chronic renal failure.	Norepinephrine	62-76	parathyroid hormone	Rattus norvegicus	23-26
2485262-0	1985	Reduced plasma noradrenaline during angiotensin II-induced acute hypertension in man.	Norepinephrine	15-28	angiotensinogen	Homo sapiens	36-50
3990518-5	1985	Dexamethasone caused an increase in ornithine decarboxylase (ODC) activity within 1 to 2 hours after which the norepinephrine and epinephrine contents increased 16 hours after the peak of ODC activity in a dose dependent manner of dexamethasone in bovine adrenal medullary chromaffin cells in primary monolayer culture.	Norepinephrine	111-125	ornithine decarboxylase	Bos taurus	36-59
2410814-0	1985	Substance P given intrathecally at the spinal T9 level increases adrenal output of adrenaline and noradrenaline in the rat.	Norepinephrine	98-111	tachykinin precursor 1	Homo sapiens	0-11
3862143-1	1985	The activity of the enzyme dihydropteridine reductase (DHPR) has been recently found to be one of the factors controlling the rate of synthesis of dopamine, norepinephrine, and serotonin, thought to be involved in the etiology of schizophrenia.	Norepinephrine	157-171	quinoid dihydropteridine reductase	Homo sapiens	27-53
3862143-1	1985	The activity of the enzyme dihydropteridine reductase (DHPR) has been recently found to be one of the factors controlling the rate of synthesis of dopamine, norepinephrine, and serotonin, thought to be involved in the etiology of schizophrenia.	Norepinephrine	157-171	quinoid dihydropteridine reductase	Homo sapiens	55-59
3990518-5	1985	Dexamethasone caused an increase in ornithine decarboxylase (ODC) activity within 1 to 2 hours after which the norepinephrine and epinephrine contents increased 16 hours after the peak of ODC activity in a dose dependent manner of dexamethasone in bovine adrenal medullary chromaffin cells in primary monolayer culture.	Norepinephrine	111-125	ornithine decarboxylase	Bos taurus	61-64
2581649-1	1985	Substance P (SP) has two distinct actions on catecholamine (CA) release from cultured bovine adrenal chromaffin cells: SP inhibits acetylcholine (ACh)- or nicotine-induced [3H]norepinephrine ([3H]NE) release; and SP protects against desensitization of ACh- or nicotine-induced [3H]NE release.	Norepinephrine	176-190	tachykinin precursor 1	Bos taurus	0-16
2986443-2	1985	The beta 1 receptors are activated primarily by norepinephrine released from the sympathetic nerves, the beta 2 by circulating epinephrine from the adrenal medulla.	Norepinephrine	48-62	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	4-10
2581649-1	1985	Substance P (SP) has two distinct actions on catecholamine (CA) release from cultured bovine adrenal chromaffin cells: SP inhibits acetylcholine (ACh)- or nicotine-induced [3H]norepinephrine ([3H]NE) release; and SP protects against desensitization of ACh- or nicotine-induced [3H]NE release.	Norepinephrine	176-190	tachykinin precursor 1	Bos taurus	13-15
2581649-1	1985	Substance P (SP) has two distinct actions on catecholamine (CA) release from cultured bovine adrenal chromaffin cells: SP inhibits acetylcholine (ACh)- or nicotine-induced [3H]norepinephrine ([3H]NE) release; and SP protects against desensitization of ACh- or nicotine-induced [3H]NE release.	Norepinephrine	176-190	tachykinin precursor 1	Bos taurus	119-121
2579749-5	1985	In contrast, the pressor responses to intracerebroventricular angiotensin II were associated with initial decreases in heart rate, cardiac output, splanchnic, renal, and adrenal nerve activity, and a fall in plasma noradrenaline at the time of the maximal blood pressure increase.	Norepinephrine	215-228	angiotensinogen	Rattus norvegicus	62-76
3885957-0	1985	Effect of epinephrine and norepinephrine on immuno-reactive insulin secretion from isolated islets of Langerhans.	Norepinephrine	26-40	insulin	Homo sapiens	60-67
3885957-5	1985	This clearly suggests that epinephrine and norepinephrine inhibit insulin release via alpha-adrenergic pathway.	Norepinephrine	43-57	insulin	Homo sapiens	66-73
4008144-10	1985	Lactate levels (+30%) as well as noradrenaline and adrenaline responses (+60%-90%) were higher in the cumulative experiment (test 1) at work loads corresponding to 70%-80% of the oxygen uptake capacity as compared to the noncumulative testing procedure (test 2).	Norepinephrine	33-46	serine protease 21	Homo sapiens	125-131
2859065-4	1985	Noradrenaline, given intrarenally, increased renin secretion between two and three fold and this response was not modified by either prazosin or idazoxan.	Norepinephrine	0-13	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	45-50
2984573-2	1985	Noradrenaline, released from sympathetic nerve terminals in the pineal gland, regulates a large nocturnal increase in melatonin synthesis by stimulating the activity of arylalkylamine N-acetyltransferase (NAT, EC 2.3.1.87) 30-70-fold.	Norepinephrine	0-13	N-acetyltransferase 1	Rattus norvegicus	205-208
2984573-4	1985	Noradrenaline acts via beta-adrenoceptors to increase pineal cyclic AMP by activating adenylate cyclase, and the activation of pineal alpha 1-adrenoceptors potentiates beta-adrenergic stimulation not only of NAT but of both cyclic AMP and cyclic GMP.	Norepinephrine	0-13	N-acetyltransferase 1	Rattus norvegicus	208-211
3921089-4	1985	The C5a relaxed strips of portal vein and pulmonary artery that were precontracted with noradrenaline (NA, 200 nM).	Norepinephrine	88-101	complement C5a receptor 1	Homo sapiens	4-7
3980067-5	1985	The vasopressin dose-response curve was significantly shifted to the left for arteries of those subjects with a family history of hypertension compared with that for arteries of subjects with no family history (e.g., response--percent of norepinephrine maximum--to 100 mU/ml = 31 +/- 23 versus 12 +/- 16; p = 0.014).	Norepinephrine	238-252	arginine vasopressin	Homo sapiens	4-15
3966753-7	1985	In edematous and hypovolemic patients, plasma hormonal responses (increases in plasma renin activity and aldosterone and norepinephrine levels) were compatible with baroreceptor-mediated release of vasopressin.	Norepinephrine	121-135	arginine vasopressin	Homo sapiens	198-209
2982658-1	1985	Arginine-vasopressin (AVP) and lysine vasopressin (LVP) elicited a dose-dependent inhibition of noradrenaline-sensitive cyclic AMP accumulation in rat cerebral cortical slices, and of forskolin-stimulated adenylate cyclase activity in a rat cerebral cortical membrane preparation.	Norepinephrine	96-109	arginine vasopressin	Rattus norvegicus	9-20
2982658-1	1985	Arginine-vasopressin (AVP) and lysine vasopressin (LVP) elicited a dose-dependent inhibition of noradrenaline-sensitive cyclic AMP accumulation in rat cerebral cortical slices, and of forskolin-stimulated adenylate cyclase activity in a rat cerebral cortical membrane preparation.	Norepinephrine	96-109	arginine vasopressin	Rattus norvegicus	38-49
3994512-4	1985	A number of other measures indicated that this is unlikely to be due to a lack of peripheral thermogenic capacity: thus plasma concentrations of glucose, free fatty acids, and ketone bodies remained normal or rose after DEF, and in vitro noradrenaline-stimulated lipolysis was normal in the presence of DEF.	Norepinephrine	238-251	UTP25 small subunit processome component	Rattus norvegicus	303-306
3838344-3	1985	Only one NPY peak was seen, which coincided with the high density peak of noradrenaline.	Norepinephrine	74-87	neuropeptide Y	Rattus norvegicus	9-12
2983040-0	1985	Norepinephrine and histamine potentiate the increases in cyclic adenosine 3":5"-monophosphate elicited by vasoactive intestinal polypeptide in mouse cerebral cortical slices: mediation by alpha 1-adrenergic and H1-histaminergic receptors.	Norepinephrine	0-14	vasoactive intestinal polypeptide	Mus musculus	106-139
3911737-0	1985	Insulin infusion normalizes cardiovascular responses and plasma noradrenaline after oral glucose in type 1 (insulin-dependent) diabetes.	Norepinephrine	64-77	insulin	Homo sapiens	0-7
2984701-0	1985	Effects of vasopressin on noradrenaline-induced cyclic AMP accumulation in rat brain slices.	Norepinephrine	26-39	arginine vasopressin	Rattus norvegicus	11-22
2984701-1	1985	Addition of arginine vasopressin (AVP) or 1-desamino-8-D-arginine vasopressin (DDAVP) to rat cortical slices resulted in significant inhibition of the rise in cyclic AMP produced by incubation with 50 microM noradrenaline.	Norepinephrine	208-221	arginine vasopressin	Rattus norvegicus	21-32
2984701-1	1985	Addition of arginine vasopressin (AVP) or 1-desamino-8-D-arginine vasopressin (DDAVP) to rat cortical slices resulted in significant inhibition of the rise in cyclic AMP produced by incubation with 50 microM noradrenaline.	Norepinephrine	208-221	arginine vasopressin	Rattus norvegicus	66-77
2984701-5	1985	The relationship between the effects of vasopressin on noradrenaline-induced cyclic AMP accumulation and its action on learning and memory is discussed.	Norepinephrine	55-68	arginine vasopressin	Rattus norvegicus	40-51
4038600-3	1985	The effect of the length of ANF peptides on the inhibition of the norepinephrine-induced contraction was studied.	Norepinephrine	66-80	natriuretic peptide A	Homo sapiens	28-31
4038600-6	1985	Further N-terminal truncation up to des-Arg101-Arg102-Ser103-Ser104 ANF still produced a marked inhibitory effect on norepinephrine.	Norepinephrine	117-131	natriuretic peptide A	Homo sapiens	68-71
3911737-1	1985	We examined whether the abnormal regulation of the cardiovascular system and plasma noradrenaline observed after oral glucose in insulin-dependent diabetic patients could be normalized by intravenous infusion of insulin.	Norepinephrine	84-97	insulin	Homo sapiens	129-136
2869641-8	1985	This may additionally indicate a beta 1-adrenoceptor-mediated effect of endogenously released noradrenaline and the requirement of sympathetic nerves for part of the beta-adrenoceptor mediated effect.	Norepinephrine	94-107	adrenoceptor beta 1	Rattus norvegicus	33-52
3929669-14	1985	We have demonstrated that, in amphibians, dopamine inhibits alpha-MSH secretion through D2-type dopaminergic receptors whereas norepinephrine and (or) epinephrine stimulate alpha-MSH secretion via beta-adrenergic receptors.	Norepinephrine	127-141	proopiomelanocortin	Homo sapiens	173-182
3896631-8	1985	Norepinephrine administration stimulates LPL activity in BAT and heart of all groups.	Norepinephrine	0-14	lipoprotein lipase	Rattus norvegicus	41-44
2984004-7	1985	When tested on intact cells, epinephrine, norepinephrine and clonidine were found to counteract, in a dose-dependent manner, the increase of cyclic AMP triggered by vasoactive intestinal peptide (VIP).	Norepinephrine	42-56	vasoactive intestinal peptide	Homo sapiens	196-199
2984004-9	1985	The physiological amines were the most efficient agonists: both epinephrine and norepinephrine inhibited VIP-induced cyclic AMP accumulation by 50-55% with KD values of 50 nM and 300 nM respectively.	Norepinephrine	80-94	vasoactive intestinal peptide	Homo sapiens	105-108
4063534-0	1985	Mobilization of extracellularly bound Ca2+ during high K+ and norepinephrine stimulation of the rabbit aorta.	Norepinephrine	62-76	carbonic anhydrase 2	Oryctolagus cuniculus	38-41
4085137-4	1985	In animals with hypertension produced by angiotensin II continuously released by an osmotic micropump, the vascular response to lysine vasopressin and angiotensin II was increased while that to norepinephrine was unchanged.	Norepinephrine	194-208	angiotensinogen	Rattus norvegicus	41-55
2865053-2	1985	Lipogenesis was inhibited by adrenergic agonists: epinephrine (alpha + beta) greater than isoproterenol (beta 1/beta 2) greater than norepinephrine (alpha 1/alpha 2, beta 1) greater than metaproterenol (beta 2), phenylephrine (alpha 1).	Norepinephrine	133-147	asparagine-linked glycosylation 12, alpha-1,6-mannosyltransferase homolog (S. cerevisiae)	Gallus gallus	149-172
2865053-2	1985	Lipogenesis was inhibited by adrenergic agonists: epinephrine (alpha + beta) greater than isoproterenol (beta 1/beta 2) greater than norepinephrine (alpha 1/alpha 2, beta 1) greater than metaproterenol (beta 2), phenylephrine (alpha 1).	Norepinephrine	133-147	asparagine-linked glycosylation 12, alpha-1,6-mannosyltransferase homolog (S. cerevisiae)	Gallus gallus	149-156
2409385-3	1985	In veins, however, the endothelium-dependent inhibitory effect of acetylcholine, ATP, and thrombin often is transient and/or modest, as it is masked by the direct stimulating action of these substances on the venous smooth muscle; arachidonic acid evokes endothelium-dependent augmentation of the contractile response to norepinephrine.	Norepinephrine	321-335	coagulation factor II, thrombin	Homo sapiens	90-98
2991349-4	1985	Onset of inhibition by norepinephrine of the PGD2-response is several fold faster than for the forskolin-response.	Norepinephrine	23-37	prostaglandin D2 synthase	Homo sapiens	45-49
2991349-5	1985	When platelets stimulated by the forskolin and PGD2 combination are exposed to norepinephrine, there is a transient increase in levels of cyclic AMP due to the potentiation of a minor beta-adrenergic component.	Norepinephrine	79-93	prostaglandin D2 synthase	Homo sapiens	47-51
2991349-11	1985	The PGD2-forskolin combination appears to stabilize the cyclic AMP-generating system of platelets against inhibition by either norepinephrine or 2",5"-dideoxyadenosine.	Norepinephrine	127-141	prostaglandin D2 synthase	Homo sapiens	4-8
3831319-3	1985	A similar effect was observed in vitro, where magnesium increased norepinephrine-stimulated NAT activity in organ-cultured pineal glands, suggesting that magnesium acts primarily on the pineal gland as opposed to some other peripheral or central site.	Norepinephrine	66-80	N-acetyltransferase 1	Rattus norvegicus	92-95
2860247-3	1985	The longlasting signal generated by the covalent MSH-receptor complex was readily and reversibly abolished by adrenaline, noradrenaline, dopamine or clonidine or by the absence of calcium.	Norepinephrine	122-135	proopiomelanocortin	Homo sapiens	49-52
3931063-4	1985	Further, the response to insulin induced hypoglycemia is blunted in SCI with high lesions, and their basal levels of norepinephrine, epinephrine, and cortisol are significantly lower than those of controls.	Norepinephrine	117-131	insulin	Homo sapiens	25-32
2860247-5	1985	Forskolin, which stimulates melanophores by direct action on the catalytic unit of the adenylate cyclase and at about the same speed as alpha-MSH, produced a slower and weaker response in the presence of noradrenaline.	Norepinephrine	204-217	proopiomelanocortin	Homo sapiens	136-145
2860247-6	1985	If MSH receptors were covalently labelled and then exposed to noradrenaline, the characteristics of the forskolin-induced response were identical to those of unlabelled cells that had not been exposed to noradrenaline.	Norepinephrine	62-75	proopiomelanocortin	Homo sapiens	3-6
3838576-0	1985	Neuropeptide Y (NPY) reduces field stimulation-evoked release of noradrenaline and enhances force of contraction in the rat portal vein.	Norepinephrine	65-78	neuropeptide Y	Rattus norvegicus	0-14
3838576-0	1985	Neuropeptide Y (NPY) reduces field stimulation-evoked release of noradrenaline and enhances force of contraction in the rat portal vein.	Norepinephrine	65-78	neuropeptide Y	Rattus norvegicus	16-19
20492973-1	1985	Norepinephrine and dopamine-?-hydroxylase, used as noradrenergic vesicle markers, were found to be decreased in the rat vas deferens 10 days after castration.	Norepinephrine	0-14	arginine vasopressin	Rattus norvegicus	120-123
2987982-2	1985	In the CA-treated vas deferens, the endogenously released noradrenaline (NA) in response to electrical field stimulation or exogenously administered NA produced rhythmic contractions (lacking a tonic component) which were abolished by prazosin - a preferential postjunctional alpha-adrenoceptor blocker.	Norepinephrine	58-71	arginine vasopressin	Rattus norvegicus	18-21
2862722-1	1985	Alpha toxin produced by Clostridium perfringens potentiated norepinephrine-evoked contraction in the isolated rat vas deferens, but itself caused no contraction within 60 min.	Norepinephrine	60-74	arginine vasopressin	Rattus norvegicus	114-117
6150711-2	1984	Recent evidence indicates that melatonin production is controlled by norepinephrine acting via alpha 1-and beta 1-adrenoceptors on pinealocytes; activation of alpha 1-adrenoceptors appears to potentiate the effects of beta 1-adrenoceptor activation.	Norepinephrine	69-83	adrenoceptor beta 1	Rattus norvegicus	107-126
6507644-0	1984	Differential effect of vasopressin on angiotensin and norepinephrine pressor action in rats.	Norepinephrine	54-68	arginine vasopressin	Rattus norvegicus	23-34
6507644-1	1984	The effect of vasopressin infusion on the pressor dose responses to angiotensin II and norepinephrine was studied in pentobarbital-anesthetized and unanesthetized nephrectomized rats.	Norepinephrine	87-101	arginine vasopressin	Rattus norvegicus	14-25
6543193-0	1984	Effects of epinephrine and norepinephrine on serum parathyroid hormone and calcium in normal subjects.	Norepinephrine	27-41	parathyroid hormone	Homo sapiens	51-70
6093936-2	1984	Norepinephrine depletion by the norepinephrine-selective neurotoxin DSP4 initially reduced the indices of (Na+,K+)-ATPase, with a significant correlation between ouabain binding and tissue norepinephrine levels 16 h after DSP4.	Norepinephrine	0-14	dual specificity phosphatase 26	Homo sapiens	68-72
6095862-6	1984	Conversely, in rabbit lung membranes, norepinephrine was approximately equipotent with epinephrine in blocking photoincorporation, indicating a beta 1 selectivity.	Norepinephrine	38-52	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	144-150
6400363-2	1984	They can serve as cotransmitters in the autonomic nervous system; for example, vasoactive intestinal peptide (VIP) is released with acetylcholine and neuropeptide Y with norepinephrine from postganglionic neurons.	Norepinephrine	170-184	vasoactive intestinal peptide	Homo sapiens	110-113
6443710-1	1984	Lesions of the ventrolateral medulla coinciding with the A1 noradrenaline cell group, in either the rabbit or the rat, cause hypertension and bradycardia accompanied by 50-fold increases in plasma vasopressin and adrenaline and a two-to-four-fold increase in plasma noradrenaline.	Norepinephrine	60-73	arginine vasopressin	Rattus norvegicus	197-208
6093936-2	1984	Norepinephrine depletion by the norepinephrine-selective neurotoxin DSP4 initially reduced the indices of (Na+,K+)-ATPase, with a significant correlation between ouabain binding and tissue norepinephrine levels 16 h after DSP4.	Norepinephrine	0-14	dual specificity phosphatase 26	Homo sapiens	222-226
6093936-2	1984	Norepinephrine depletion by the norepinephrine-selective neurotoxin DSP4 initially reduced the indices of (Na+,K+)-ATPase, with a significant correlation between ouabain binding and tissue norepinephrine levels 16 h after DSP4.	Norepinephrine	32-46	dual specificity phosphatase 26	Homo sapiens	68-72
6093936-2	1984	Norepinephrine depletion by the norepinephrine-selective neurotoxin DSP4 initially reduced the indices of (Na+,K+)-ATPase, with a significant correlation between ouabain binding and tissue norepinephrine levels 16 h after DSP4.	Norepinephrine	32-46	dual specificity phosphatase 26	Homo sapiens	222-226
6093936-2	1984	Norepinephrine depletion by the norepinephrine-selective neurotoxin DSP4 initially reduced the indices of (Na+,K+)-ATPase, with a significant correlation between ouabain binding and tissue norepinephrine levels 16 h after DSP4.	Norepinephrine	189-203	dual specificity phosphatase 26	Homo sapiens	68-72
6492999-6	1984	The present results combined with previous findings suggest that ATP and norepinephrine act as cotransmitters in the vas deferens of several species.	Norepinephrine	73-87	arginine vasopressin	Rattus norvegicus	117-120
6595669-5	1984	There was a strong positive correlation between the NGF mRNA level and norepinephrine content, a measure of the density of sympathetic innervation.	Norepinephrine	71-85	nerve growth factor	Homo sapiens	52-55
6397416-4	1984	In the noradrenaline elevated group plasma insulin concentration and plasma insulin/glucagon molar ratio significantly decreased until 30 min after the acupuncture.	Norepinephrine	7-20	insulin	Homo sapiens	43-50
6397416-4	1984	In the noradrenaline elevated group plasma insulin concentration and plasma insulin/glucagon molar ratio significantly decreased until 30 min after the acupuncture.	Norepinephrine	7-20	insulin	Homo sapiens	76-83
6527783-1	1984	A comparative study of the noradrenaline storing vesicles in vas deferens from ox and rat was performed.	Norepinephrine	27-40	arginine vasopressin	Rattus norvegicus	61-64
6084782-4	1984	The beta 1-selective antagonist practolol preferentially antagonized the human atrial response to noradrenaline (beta 1-selective) as opposed to fenoterol (beta 2-selective), whereas the beta 2-selective antagonist ICI 118,551 preferentially antagonized the response to fenoterol.	Norepinephrine	98-111	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	4-10
6084782-4	1984	The beta 1-selective antagonist practolol preferentially antagonized the human atrial response to noradrenaline (beta 1-selective) as opposed to fenoterol (beta 2-selective), whereas the beta 2-selective antagonist ICI 118,551 preferentially antagonized the response to fenoterol.	Norepinephrine	98-111	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	113-119
6092538-3	1984	The S-100 protein release was also enhanced by isoproterenol, norepinephrine, ACTH, and dibutyryl cyclic AMP, which all increase the lipolysis by increasing cyclic AMP levels in the tissue.	Norepinephrine	62-76	S100 calcium binding protein A1	Homo sapiens	4-9
6522858-0	1984	[Action mechanism of angiotensin II on norepinephrine release].	Norepinephrine	39-53	angiotensinogen	Homo sapiens	21-35
6519191-2	1984	Organ weights, liver glycogen, adrenal ascorbic acid, hematological and serum biochemical analysis and maximum contraction of vas deferens induced by noradrenaline were measured.	Norepinephrine	150-163	arginine vasopressin	Rattus norvegicus	126-129
6594180-5	1984	These medullary fibers, possibly originating from the norepinephrine/epinephrine-containing ventrolateral cell group (A1/C1), then appear to join additional fibers from the scattered dopamine-containing neurons positioned in the caudal midbrain (A8 CA cell group).	Norepinephrine	54-68	BCL2 related protein A1	Homo sapiens	118-124
6519191-7	1984	Maximum contraction of vas deferens induced by noradrenaline was potentiated in stress-loaded rats.	Norepinephrine	47-60	arginine vasopressin	Rattus norvegicus	23-26
6152637-3	1984	When tested against responses of Purkinje cell to depressant putative neurotransmitters, namely, GABA, glycine, taurine, 5-hydroxytryptamine and noradrenaline, it was observed that AII specifically enhanced depressant action of GABA, while the responses to other substances were unaffected.	Norepinephrine	145-158	angiotensinogen	Rattus norvegicus	181-184
6530555-1	1984	After perfusing the vascular circuit of the mesenteric artery of the rat with a Ca-free solution for 20 min, extracellular Ca was depleted, and the vasoconstrictor effect of high K solutions was abolished, while the vasopressin response was reduced by 40%, serotonin by 30% and noradrenaline and adrenaline responses by about 20%.	Norepinephrine	278-291	arginine vasopressin	Rattus norvegicus	216-227
6530555-5	1984	Noradrenaline and adrenaline showed crossed tachyphylaxis, which depressed the responses to serotonin and vasopressin.	Norepinephrine	0-13	arginine vasopressin	Rattus norvegicus	106-117
6547992-0	1984	Norepinephrine-like effects of neuropeptide Y on LH release in the rat.	Norepinephrine	0-14	neuropeptide Y	Rattus norvegicus	31-45
6547992-1	1984	Neuropeptide Y, a recently isolated neuropeptide exhibited norepinephrine-like effects on LH release after intracerebroventricular administration at doses from 0.5 to 10 micrograms.	Norepinephrine	59-73	neuropeptide Y	Rattus norvegicus	0-14
6381693-5	1984	The beta-1 adrenoceptor-mediated chronotropic effects of these phenethylamines were inconsistently affected by alpha-methyl substitution, with an increase in potency being observed for alpha-methyl substitution of norepinephrine and decreases in potency being observed for alpha-methyl substitution of epinephrine and dopamine.	Norepinephrine	214-228	adrenoceptor beta 1	Rattus norvegicus	4-23
6099973-1	1984	The effect of an acute infection with Trypanosoma brucei on the reactivity of the rat vas deferens to noradrenaline, tyramine and field stimulation was studied.	Norepinephrine	102-115	arginine vasopressin	Rattus norvegicus	86-89
6099973-4	1984	Also both noradrenaline and tyramine were more effective on the infected vas deferens suggesting a post-junctional sensitization of alpha adrenoceptors.	Norepinephrine	10-23	arginine vasopressin	Rattus norvegicus	73-76
6208488-0	1984	The outward transport of axoplasmic noradrenaline induced by a rise of the sodium concentration in the adrenergic nerve endings of the rat vas deferens.	Norepinephrine	36-49	arginine vasopressin	Rattus norvegicus	139-142
6381272-0	1984	Decreased response of epinephrine and norepinephrine to insulin-induced hypoglycemia in diabetic autonomic neuropathy.	Norepinephrine	38-52	insulin	Homo sapiens	56-63
6381272-7	1984	The data demonstrate that the responses of plasma epinephrine and norepinephrine to insulin-induced hypoglycemia are impaired in diabetics with autonomic neuropathy.	Norepinephrine	66-80	insulin	Homo sapiens	84-91
6146712-7	1984	However, POB shifted the dose-response curve for NAT induction by norepinephrine (NE) to the left.	Norepinephrine	66-80	N-acetyltransferase 1	Rattus norvegicus	49-52
6147772-3	1984	Its effect on vas deferens is partly mediated via alpha 2-adrenoceptors and due to the released noradrenaline, in guinea pig ileum, however, it seems likely that it releases an unidentified inhibitory substance which, in fact, inhibits the release of acetylcholine, and thereby twitches of the ileum.	Norepinephrine	96-109	arginine vasopressin	Rattus norvegicus	14-17
6518670-1	1984	In guinea-pig isolated atria, angiotensin I and angiotensin II produced concentration dependent increases in the rate of spontaneous beating and in the release of noradrenaline produced by field stimulation of sympathetic nerves.	Norepinephrine	163-176	angiotensinogen	Rattus norvegicus	48-62
6330067-4	1984	Angiotensin II stimulation of glycogen phosphorylase in isolated rat hepatocytes (maximal stimulation 780%, EC50 = 0.4 nM) was completely inhibited by 10 mM dithiothreitol, a concentration which also abolished high affinity site binding; phosphorylase stimulation by glucagon and norepinephrine under these conditions was unaltered.	Norepinephrine	280-294	angiotensinogen	Rattus norvegicus	0-14
6206433-0	1984	Substance P, injected intrathecally, antagonizes the spinal antinociceptive effect of morphine, baclofen and noradrenaline.	Norepinephrine	109-122	tachykinin precursor 1	Homo sapiens	0-11
6206433-1	1984	The effect of substance P on the antinociceptive effect of morphine, baclofen and noradrenaline in the spinal cord was examined in the tail-flick and hot plate tests, after intrathecal administration.	Norepinephrine	82-95	tachykinin precursor 1	Homo sapiens	14-25
6206433-9	1984	These results suggest that alterations in the function of substance P in the spinal cord may contribute to the spinal antinociceptive effects of morphine, baclofen and noradrenaline.	Norepinephrine	168-181	tachykinin precursor 1	Homo sapiens	58-69
6433824-9	1984	The present study provides direct and indirect evidences that the contractile effect of 5-hydroxytryptamine on the rat vas deferens is prevailingly due to the release of noradrenaline; in the lower part of the concentration-response curve also direct effects are involved which are mediated by an interaction with both tryptaminergic "D" receptors and alpha 1-adrenoceptors.	Norepinephrine	170-183	arginine vasopressin	Rattus norvegicus	119-122
6424235-2	1984	This monoamine oxidase B enzyme was somewhat distinct from B enzymes from other sources, in that noradrenaline was a much poorer substrate than serotonin.	Norepinephrine	97-110	monoamine oxidase B	Bos taurus	5-24
6329421-2	1984	The possible role of cyclic AMP as an obligatory mediator of the excitatory and inhibitory actions of noradrenaline is discussed.	Norepinephrine	102-115	transmembrane serine protease 5	Rattus norvegicus	28-31
6146542-7	1984	Insulin levels were partially suppressed by noradrenaline, while a small rise in circulating insulin was observed with adrenaline which was also associated with a large rebound rise in insulin secretion on cessation of the infusion.	Norepinephrine	44-57	insulin	Homo sapiens	0-7
6372521-8	1984	It is proposed that AII generated by hemorrhage facilitates norepinephrine release from enteric sympathetic nerves.	Norepinephrine	60-74	angiotensinogen	Rattus norvegicus	20-23
6372521-9	1984	The norepinephrine released by AII stimulates jejunal absorption by enhancing transepithelial transport processes or by altering the balance of Starling forces governing fluid absorption across enteric capillaries.	Norepinephrine	4-18	angiotensinogen	Rattus norvegicus	31-34
6370665-8	1984	It is suggested that AII is generated after ECF reduction and increases jejunal fluid absorption by facilitating the release of norepinephrine from enteric sympathetic nerves.	Norepinephrine	128-142	angiotensinogen	Rattus norvegicus	21-24
6739457-0	1984	[Intracellular hormonal function of acetylcholine and noradrenaline: the regulation of the catalase level in liver cells].	Norepinephrine	54-67	catalase	Rattus norvegicus	91-99
6203789-4	1984	In contrast, the inhibition of PRL secretion by norepinephrine (NE) required much higher doses and lacked specificity.	Norepinephrine	48-62	prolactin	Homo sapiens	31-34
6739457-3	1984	Noradrenaline injection to animals (1.5 to 15 micrograms/100 g) or preincubation of the hepatic homogenate with noradrenaline (10(-6) to 10(-3) M) produces a rise of the catalase activity (mainly of its bound form), being blocked by actinomycine D and non-blocked by propranolol.	Norepinephrine	0-13	catalase	Rattus norvegicus	170-178
6739457-3	1984	Noradrenaline injection to animals (1.5 to 15 micrograms/100 g) or preincubation of the hepatic homogenate with noradrenaline (10(-6) to 10(-3) M) produces a rise of the catalase activity (mainly of its bound form), being blocked by actinomycine D and non-blocked by propranolol.	Norepinephrine	112-125	catalase	Rattus norvegicus	170-178
6739457-4	1984	Acetylcholine- and noradrenaline action on the catalase level is not mediated by cyclic nucleotides and may be considered as intracellular hormonal effect.	Norepinephrine	19-32	catalase	Rattus norvegicus	47-55
6091416-0	1984	Corticotropin-releasing factor increases noradrenaline turnover in the median eminence and reduces noradrenaline turnover in the paraventricular region of the hypophysectomized male rat.	Norepinephrine	41-54	corticotropin releasing hormone	Rattus norvegicus	0-30
6091416-0	1984	Corticotropin-releasing factor increases noradrenaline turnover in the median eminence and reduces noradrenaline turnover in the paraventricular region of the hypophysectomized male rat.	Norepinephrine	99-112	corticotropin releasing hormone	Rattus norvegicus	0-30
6145297-7	1984	The dopamine concentration in the cerebral cortex increased five days after, and the norepinephrine concentration in the diencephalon increased 24 h after the last administration of CCl4.	Norepinephrine	85-99	C-C motif chemokine ligand 4	Rattus norvegicus	182-186
6329497-11	1984	These results suggested that neurotensin inhibited contractile activity of canine intestine by acting on neural receptors to release norepinephrine.	Norepinephrine	133-147	neurotensin	Canis lupus familiaris	29-40
6379758-2	1984	NPY probably co-exists with noradrenaline in such fibers since chemical or surgical sympathectomy eliminated both NPY and noradrenaline from perivascular nerve fibers and since double staining demonstrated dopamine-beta-hydroxylase, the enzyme that catalyzes the conversion of dopamine to noradrenaline, and NPY in the same perivascular nerve fibers.	Norepinephrine	28-41	dopamine beta-hydroxylase	Oryctolagus cuniculus	206-231
6143234-1	1984	As previously shown, the beta-adrenergic agonists isoproterenol, epinephrine and norepinephrine stimulate prolactin (PRL) release from superfused rat anterior pituitary cell aggregates.	Norepinephrine	81-95	prolactin	Rattus norvegicus	106-115
6705443-5	1984	beta-Blockade potentiated BP responses to norepinephrine and angiotensin II: Thirty-five percent less norepinephrine and 52% less angiotensin II were required to increase mean BP by 15 mm Hg.	Norepinephrine	42-56	angiotensinogen	Homo sapiens	130-144
6705443-5	1984	beta-Blockade potentiated BP responses to norepinephrine and angiotensin II: Thirty-five percent less norepinephrine and 52% less angiotensin II were required to increase mean BP by 15 mm Hg.	Norepinephrine	102-116	angiotensinogen	Homo sapiens	61-75
6089134-6	1984	These findings are consistent with a hyperactivity of norepinephrine pathways in spontaneously hypertensive rats, leading to a reduced number of cardiac post-junctional secretin/VIP receptors bound to adenylate cyclase.	Norepinephrine	54-68	vasoactive intestinal peptide	Rattus norvegicus	178-181
6707922-5	1984	(1-Deaminopenicillamine, 4-valine)-8-D-arginine-vasopressin, a competitive antagonist of the pressor effects of vasopressin, partially inhibited the cerebral vasoconstriction produced by vasopressin in vivo and in vitro without affecting the vasoconstrictor responses to norepinephrine, 5-hydroxytryptamine and potassium chloride.	Norepinephrine	271-285	arginine vasopressin	Homo sapiens	48-59
6707922-5	1984	(1-Deaminopenicillamine, 4-valine)-8-D-arginine-vasopressin, a competitive antagonist of the pressor effects of vasopressin, partially inhibited the cerebral vasoconstriction produced by vasopressin in vivo and in vitro without affecting the vasoconstrictor responses to norepinephrine, 5-hydroxytryptamine and potassium chloride.	Norepinephrine	271-285	arginine vasopressin	Homo sapiens	112-123
6707922-5	1984	(1-Deaminopenicillamine, 4-valine)-8-D-arginine-vasopressin, a competitive antagonist of the pressor effects of vasopressin, partially inhibited the cerebral vasoconstriction produced by vasopressin in vivo and in vitro without affecting the vasoconstrictor responses to norepinephrine, 5-hydroxytryptamine and potassium chloride.	Norepinephrine	271-285	arginine vasopressin	Homo sapiens	112-123
6473156-7	1984	Norepinephrine (5 micrograms/kg/min) also reversed the effect of VIP on the small intestine and colon.	Norepinephrine	0-14	vasoactive intestinal peptide	Rattus norvegicus	65-68
6473156-0	1984	Angiotensin II and norepinephrine antagonize the secretory effect of VIP in rat ileum and colon.	Norepinephrine	19-33	vasoactive intestinal peptide	Rattus norvegicus	69-72
6366415-1	1984	Decline of plasma dopamine (DA), norepinephrine (NE), and epinephrine (EP) levels after iv administration of a 100 microgram bolus of LRF has been reported in normal men.	Norepinephrine	33-47	CREB3 regulatory factor	Homo sapiens	134-137
6473156-2	1984	We assessed the ability of angiotensin II (AII) and norepinephrine (NE) to block the secretion evoked by VIP, in vivo.	Norepinephrine	52-66	vasoactive intestinal peptide	Rattus norvegicus	105-108
6142006-1	1984	We tested the hypothesis that (1) beta 1-selective and nonselective beta adrenoceptor blockades have a different influence on stress-induced catecholamine overshoot, and (2) beta 1-selective blockade shifts the epinephrine/norepinephrine ratio in favor of norepinephrine.	Norepinephrine	223-237	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	174-180
6712358-4	1984	Doubling the concentration of glucose in the solution bathing the isolated vas deferens from rats fasted for 24 hr increased the responses to noradrenaline and tyramine.	Norepinephrine	142-155	arginine vasopressin	Rattus norvegicus	75-78
6142006-1	1984	We tested the hypothesis that (1) beta 1-selective and nonselective beta adrenoceptor blockades have a different influence on stress-induced catecholamine overshoot, and (2) beta 1-selective blockade shifts the epinephrine/norepinephrine ratio in favor of norepinephrine.	Norepinephrine	256-270	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	174-180
6141282-7	1984	The decrease and recovery of enzyme activity in the heart after administration of the reversible noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) were parallel to the recovery of norepinephrine content and desmethylimipramine binding.	Norepinephrine	207-221	dual specificity phosphatase 26	Homo sapiens	168-172
6319679-0	1984	Benzodiazepines: rat pinealocyte binding sites and augmentation of norepinephrine-stimulated N-acetyltransferase activity.	Norepinephrine	67-81	N-acetyltransferase 1	Rattus norvegicus	93-112
6319679-5	1984	In addition, the effects of diazepam on norepinephrine-stimulated N-acetyltransferase (NAT) activity were studied in organ culture and dissociated cell culture.	Norepinephrine	40-54	N-acetyltransferase 1	Rattus norvegicus	66-85
6319679-5	1984	In addition, the effects of diazepam on norepinephrine-stimulated N-acetyltransferase (NAT) activity were studied in organ culture and dissociated cell culture.	Norepinephrine	40-54	N-acetyltransferase 1	Rattus norvegicus	87-90
6319679-6	1984	Diazepam (10-50 microM) both prolonged and increased the magnitude of the norepinephrine-induced increase in NAT activity but did not affect the initial rate of rise of enzyme activity.	Norepinephrine	74-88	N-acetyltransferase 1	Rattus norvegicus	109-112
6321815-3	1984	The combined administration of vasopressin or norepinephrine with MK421 eliminated the hypertensive effect of vasopressin or norepinephrine.	Norepinephrine	46-60	arginine vasopressin	Rattus norvegicus	110-121
6321815-3	1984	The combined administration of vasopressin or norepinephrine with MK421 eliminated the hypertensive effect of vasopressin or norepinephrine.	Norepinephrine	125-139	arginine vasopressin	Rattus norvegicus	31-42
6321815-5	1984	The combined administration of norepinephrine with MK421 induced further increases in urinary kallikrein and kinin excretion when compared to rats infused with norepinephrine alone, whereas the combined administration of vasopressin with MK421 did not induce any changes in them when compared to rats infused with vasopressin alone.	Norepinephrine	31-45	arginine vasopressin	Rattus norvegicus	314-325
6400630-6	1984	Thus, all endocrine cells and nerves containing the recognized regulatory peptides, as well as amines and classical neurotransmitters like acetylcholine and noradrenaline, contain significant quantities of immunostainable neuron-specific enolase.	Norepinephrine	157-170	enolase 2	Homo sapiens	222-245
6689959-0	1984	Characteristics of the norepinephrine-sensitive Ca2+ store in vascular smooth muscle.	Norepinephrine	23-37	carbonic anhydrase 2	Oryctolagus cuniculus	48-51
6595999-4	1984	Vasodilatory renal prostaglandins are relatively unimportant under normal circumstances but play a modulatory role after ischemia or in the presence of increased concentrations of vasoconstrictor substances such as angiotensin II (ANG II), vasopressin or norepinephrine.	Norepinephrine	255-269	angiotensinogen	Rattus norvegicus	231-237
6537889-2	1984	Prolactin decreased the tension in the hypophyseal-adrenal system, normalized adrenaline and noradrenaline content in the heart and adrenals, and prevented the development of pathological alterations in the myocardium under emotional-painful stress.	Norepinephrine	93-106	prolactin	Rattus norvegicus	0-9
6689959-4	1984	The rates of Ca2+ leakage and Ca2+ filling of the norepinephrine-sensitive store were much faster than those of the caffeine-sensitive one.	Norepinephrine	50-64	carbonic anhydrase 2	Oryctolagus cuniculus	13-16
6689959-7	1984	The release of Ca2+ from the caffeine-sensitive store could be activated by Ca2+ itself when the skinned muscle was loaded with Ca2+ above 10(-6) M. These results suggest that the norepinephrine-sensitive Ca2+ store is distinct from a large fraction of the caffeine-sensitive one, and that the norepinephrine-sensitive store is close to the cell membrane.	Norepinephrine	180-194	carbonic anhydrase 2	Oryctolagus cuniculus	15-18
6689959-4	1984	The rates of Ca2+ leakage and Ca2+ filling of the norepinephrine-sensitive store were much faster than those of the caffeine-sensitive one.	Norepinephrine	50-64	carbonic anhydrase 2	Oryctolagus cuniculus	30-33
6689959-7	1984	The release of Ca2+ from the caffeine-sensitive store could be activated by Ca2+ itself when the skinned muscle was loaded with Ca2+ above 10(-6) M. These results suggest that the norepinephrine-sensitive Ca2+ store is distinct from a large fraction of the caffeine-sensitive one, and that the norepinephrine-sensitive store is close to the cell membrane.	Norepinephrine	180-194	carbonic anhydrase 2	Oryctolagus cuniculus	76-79
6689959-5	1984	The amplitude of the norepinephrine-induced contraction in Ca2+-free medium also depended on the amount of Ca2+ present in the caffeine-sensitive store.	Norepinephrine	21-35	carbonic anhydrase 2	Oryctolagus cuniculus	59-62
6689959-7	1984	The release of Ca2+ from the caffeine-sensitive store could be activated by Ca2+ itself when the skinned muscle was loaded with Ca2+ above 10(-6) M. These results suggest that the norepinephrine-sensitive Ca2+ store is distinct from a large fraction of the caffeine-sensitive one, and that the norepinephrine-sensitive store is close to the cell membrane.	Norepinephrine	180-194	carbonic anhydrase 2	Oryctolagus cuniculus	76-79
6689959-7	1984	The release of Ca2+ from the caffeine-sensitive store could be activated by Ca2+ itself when the skinned muscle was loaded with Ca2+ above 10(-6) M. These results suggest that the norepinephrine-sensitive Ca2+ store is distinct from a large fraction of the caffeine-sensitive one, and that the norepinephrine-sensitive store is close to the cell membrane.	Norepinephrine	180-194	carbonic anhydrase 2	Oryctolagus cuniculus	76-79
6689959-5	1984	The amplitude of the norepinephrine-induced contraction in Ca2+-free medium also depended on the amount of Ca2+ present in the caffeine-sensitive store.	Norepinephrine	21-35	carbonic anhydrase 2	Oryctolagus cuniculus	107-110
6689959-7	1984	The release of Ca2+ from the caffeine-sensitive store could be activated by Ca2+ itself when the skinned muscle was loaded with Ca2+ above 10(-6) M. These results suggest that the norepinephrine-sensitive Ca2+ store is distinct from a large fraction of the caffeine-sensitive one, and that the norepinephrine-sensitive store is close to the cell membrane.	Norepinephrine	294-308	carbonic anhydrase 2	Oryctolagus cuniculus	15-18
6689959-7	1984	The release of Ca2+ from the caffeine-sensitive store could be activated by Ca2+ itself when the skinned muscle was loaded with Ca2+ above 10(-6) M. These results suggest that the norepinephrine-sensitive Ca2+ store is distinct from a large fraction of the caffeine-sensitive one, and that the norepinephrine-sensitive store is close to the cell membrane.	Norepinephrine	294-308	carbonic anhydrase 2	Oryctolagus cuniculus	76-79
6324962-0	1984	Calmodulin-induced feeding in the satiated cat: evidence for involvement of calcium and norepinephrine in the brain.	Norepinephrine	88-102	calmodulin 1	Homo sapiens	0-10
6689959-7	1984	The release of Ca2+ from the caffeine-sensitive store could be activated by Ca2+ itself when the skinned muscle was loaded with Ca2+ above 10(-6) M. These results suggest that the norepinephrine-sensitive Ca2+ store is distinct from a large fraction of the caffeine-sensitive one, and that the norepinephrine-sensitive store is close to the cell membrane.	Norepinephrine	294-308	carbonic anhydrase 2	Oryctolagus cuniculus	76-79
6689959-7	1984	The release of Ca2+ from the caffeine-sensitive store could be activated by Ca2+ itself when the skinned muscle was loaded with Ca2+ above 10(-6) M. These results suggest that the norepinephrine-sensitive Ca2+ store is distinct from a large fraction of the caffeine-sensitive one, and that the norepinephrine-sensitive store is close to the cell membrane.	Norepinephrine	294-308	carbonic anhydrase 2	Oryctolagus cuniculus	76-79
6689959-8	1984	In vascular smooth muscle, under physiological conditions, Ca2+ released from the norepinephrine-sensitive store by norepinephrine may induce Ca2+ release from the caffeine-sensitive Ca2+ store which may be comprised of the sarcoplasmic reticulum.	Norepinephrine	82-96	carbonic anhydrase 2	Oryctolagus cuniculus	59-62
6689959-8	1984	In vascular smooth muscle, under physiological conditions, Ca2+ released from the norepinephrine-sensitive store by norepinephrine may induce Ca2+ release from the caffeine-sensitive Ca2+ store which may be comprised of the sarcoplasmic reticulum.	Norepinephrine	82-96	carbonic anhydrase 2	Oryctolagus cuniculus	142-145
6689959-8	1984	In vascular smooth muscle, under physiological conditions, Ca2+ released from the norepinephrine-sensitive store by norepinephrine may induce Ca2+ release from the caffeine-sensitive Ca2+ store which may be comprised of the sarcoplasmic reticulum.	Norepinephrine	82-96	carbonic anhydrase 2	Oryctolagus cuniculus	142-145
6689959-8	1984	In vascular smooth muscle, under physiological conditions, Ca2+ released from the norepinephrine-sensitive store by norepinephrine may induce Ca2+ release from the caffeine-sensitive Ca2+ store which may be comprised of the sarcoplasmic reticulum.	Norepinephrine	116-130	carbonic anhydrase 2	Oryctolagus cuniculus	59-62
6689959-8	1984	In vascular smooth muscle, under physiological conditions, Ca2+ released from the norepinephrine-sensitive store by norepinephrine may induce Ca2+ release from the caffeine-sensitive Ca2+ store which may be comprised of the sarcoplasmic reticulum.	Norepinephrine	116-130	carbonic anhydrase 2	Oryctolagus cuniculus	142-145
6689959-8	1984	In vascular smooth muscle, under physiological conditions, Ca2+ released from the norepinephrine-sensitive store by norepinephrine may induce Ca2+ release from the caffeine-sensitive Ca2+ store which may be comprised of the sarcoplasmic reticulum.	Norepinephrine	116-130	carbonic anhydrase 2	Oryctolagus cuniculus	142-145
6099769-0	1984	Effects of angiotensin II and ACE inhibitors on electrically stimulated noradrenaline release from superfused rat brain slices.	Norepinephrine	72-85	angiotensinogen	Rattus norvegicus	11-25
6383859-4	1984	NGF-treatment led to lower contents of adrenaline, noradrenaline and dopamine.	Norepinephrine	51-64	nerve growth factor	Homo sapiens	0-3
6383859-9	1984	It may be concluded that NGF influences the liberation of adrenaline, noradrenaline and dopamine in tissue culture: though NGF treated cells contained more catecholamine granula, the catecholamines were retained in the pheochromocytoma cells.	Norepinephrine	70-83	nerve growth factor	Homo sapiens	25-28
6526264-4	1984	The physiological responses of vas deferens to norepinephrine are not altered by cycloheximide and actinomycin D.	Norepinephrine	47-61	arginine vasopressin	Rattus norvegicus	31-34
6099769-0	1984	Effects of angiotensin II and ACE inhibitors on electrically stimulated noradrenaline release from superfused rat brain slices.	Norepinephrine	72-85	angiotensin I converting enzyme	Rattus norvegicus	30-33
6140273-6	1984	Norepinephrine, likewise, caused a suppression of PRL secretion from adenomatous and nonadenomatous pituitary cells.	Norepinephrine	0-14	prolactin	Homo sapiens	50-53
6199591-8	1984	beta-Blockade with propranolol (nonselective), 80 mg four times a day, or atenolol (beta 1-selective), 100 mg once a day, antagonized the hypokalemic effect of isoproterenol as well as the rise in norepinephrine, but when isoproterenol was infused in doses high enough to overcome the blockade of the heart rate response, the effects on norepinephrine and potassium were abolished by propranolol and not by atenolol.	Norepinephrine	197-211	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	84-90
6204165-2	1984	With a high salt intake, plasma catecholamine levels were lower at each grade of exercise; the norepinephrine-renin response curve was shifted to the right and the norepinephrine-heart rate response curve to the left.	Norepinephrine	95-109	renin	Homo sapiens	110-115
6199591-8	1984	beta-Blockade with propranolol (nonselective), 80 mg four times a day, or atenolol (beta 1-selective), 100 mg once a day, antagonized the hypokalemic effect of isoproterenol as well as the rise in norepinephrine, but when isoproterenol was infused in doses high enough to overcome the blockade of the heart rate response, the effects on norepinephrine and potassium were abolished by propranolol and not by atenolol.	Norepinephrine	337-351	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	84-90
6690484-4	1984	In contrast, the pressor response to graded doses of norepinephrine was preserved in potassium-deficient rats; therefore, the decreased response to AII was not due to a generalized defect in vascular reactivity.	Norepinephrine	53-67	angiotensinogen	Rattus norvegicus	148-151
6681179-5	1983	Circulating norepinephrine correlated in a positive fashion with renin before and after operation.	Norepinephrine	12-26	renin	Homo sapiens	65-70
6195528-8	1983	Vasoactive intestinal peptide (VIP) on the other hand increases cyclic AMP in the absence of noradrenaline.	Norepinephrine	93-106	vasoactive intestinal peptide	Rattus norvegicus	31-34
6139182-4	1983	The relative potencies of isoprenaline, adrenaline, and noradrenaline for inhibition of (+/-)-[125I]iodocyanopindolol binding and activation of adenylate cyclase were 1:10:10, indicating a population composed mainly of beta 1-adrenoceptors.	Norepinephrine	56-69	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	219-225
6196081-7	1983	Results of these experiments revealed that peak 1 primarily represents extracellular norepinephrine, while peak 2 is primarily produced by extracellular 5-hydroxyindoleacetic acid (5-HIAA).	Norepinephrine	85-99	pseudopodium-enriched atypical kinase 1	Rattus norvegicus	43-49
6350810-1	1983	We examined the response of plasma glucose concentration and glucose counterregulatory factors (eg, glucagon, epinephrine, growth hormone, cortisol, and norepinephrine) to insulin-induced hypoglycemia in four patients with Shy-Drager syndrome and in five control subjects to determine if glucose counterregulation occurred in the patients with sympathetic and parasympathetic nervous system defects.	Norepinephrine	153-167	insulin	Homo sapiens	172-179
6356743-14	1983	There was a positive correlation between the mean increment in active renin and in norepinephrine levels in diabetic patients.	Norepinephrine	83-97	renin	Homo sapiens	70-75
6137925-6	1983	In the presence of TSH, the cGMP response to norepinephrine was not modified; however, the increase of cAMP levels was inhibited by norepinephrine at doses inactive on cAMP accumulation, but active on cGMP levels.	Norepinephrine	132-146	cathelicidin antimicrobial peptide	Homo sapiens	103-107
6137925-6	1983	In the presence of TSH, the cGMP response to norepinephrine was not modified; however, the increase of cAMP levels was inhibited by norepinephrine at doses inactive on cAMP accumulation, but active on cGMP levels.	Norepinephrine	132-146	cathelicidin antimicrobial peptide	Homo sapiens	168-172
6135966-0	1983	Presynaptic mediation by alpha 2-, beta 1- and beta 2-adrenoceptors of endogenous noradrenaline and dopamine release from slices of rat hypothalamus.	Norepinephrine	82-95	adrenoceptor beta 1	Rattus norvegicus	25-67
6413344-4	1983	The effects of insulin were not blocked by preincubation with phentolamine and they enhanced the noradrenaline effect.	Norepinephrine	97-110	insulin	Homo sapiens	15-22
6135495-3	1983	Peripheral injection of OXT facilitated the alpha-MPT-induced disappearance of noradrenaline (NA) in the mesencephalon.	Norepinephrine	79-92	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	24-27
6313268-14	1983	These experiments indicate that noradrenaline, released by short trains of impulses applied at low frequency to hypogastric nerve terminals activates prejunctional alpha 2-adrenoceptors in the prostatic segment of the vas deferens.	Norepinephrine	32-45	arginine vasopressin	Rattus norvegicus	218-221
6345203-4	1983	The renin increase was neurogenic because plasma norepinephrine increased, the response was abolished by beta blockade, and renin did not increase in patients with denervated transplanted kidneys.	Norepinephrine	49-63	renin	Homo sapiens	4-9
6840820-0	1983	Norepinephrine-induced potentiation of arginine vasopressin reactivity in arterioles of the spontaneously hypertensive rat.	Norepinephrine	0-14	arginine vasopressin	Rattus norvegicus	48-59
6622812-0	1983	[Effect of calcium antagonists on the response of the rat vas deferens to noradrenaline and field stimulation].	Norepinephrine	74-87	arginine vasopressin	Rattus norvegicus	58-61
6354532-6	1983	It is concluded that in the pithed rat, basal arterial blood pressure and the height of pressor responses to either postganglionic sympathetic nerve activation or intravenous noradrenaline depend on converting enzyme activity maintaining circulating angiotensin II levels.	Norepinephrine	175-188	angiotensinogen	Rattus norvegicus	250-264
6840400-2	1983	In response to insulin-induced hypoglycemia, significant increases in epinephrine, norepinephrine, cortisol, and growth hormone were measured in all subjects, while in five of the six patients glucagon levels did not increase at all.	Norepinephrine	83-97	insulin	Homo sapiens	15-22
6840820-8	1983	Vasopressin-induced vasoconstriction was potentiated by norepinephrine in the SHR, demonstrated by the significant shift of the curve up and to the left of the SHR response curve to vasopressin alone (p less than 0.01).	Norepinephrine	56-70	arginine vasopressin	Rattus norvegicus	0-11
6840820-8	1983	Vasopressin-induced vasoconstriction was potentiated by norepinephrine in the SHR, demonstrated by the significant shift of the curve up and to the left of the SHR response curve to vasopressin alone (p less than 0.01).	Norepinephrine	56-70	arginine vasopressin	Rattus norvegicus	182-193
6840820-13	1983	Our results support a role for vasopressin as a potential vasoconstrictor in the developing stage of SHR hypertension which may be modulated by norepinephrine and thus contribute to the elevated total peripheral resistance observed.	Norepinephrine	144-158	arginine vasopressin	Rattus norvegicus	31-42
6866954-4	1983	The preliminary use of somatotropin or its fragment sharply increased the number of noradrenaline-activated neurons.	Norepinephrine	84-97	growth hormone 1	Rattus norvegicus	23-35
6866336-2	1983	Angiotensin II (7.5 and 15.0 micrograms/ml) caused significant increases in both neuronal and growth media norepinephrine levels, which were inhibited by saralasin.	Norepinephrine	107-121	angiotensinogen	Rattus norvegicus	0-14
6878754-0	1983	Regulation of neurotensin secretion in mammalian C cell lines: potassium and norepinephrine affect the rapid release of the peptide.	Norepinephrine	77-91	neurotensin	Homo sapiens	14-25
6878754-7	1983	Ca2+ was required for NT release induced by the Ca2+ ionophore, ionomycin, also K+ (50 mM) and norepinephrine (NE).	Norepinephrine	95-109	neurotensin	Homo sapiens	22-24
6866336-0	1983	Angiotensin II stimulates changes in the norepinephrine content of primary cultures of rat brain.	Norepinephrine	41-55	angiotensinogen	Rattus norvegicus	0-14
6130966-1	1983	Application of exogenous ATP or of noradrenaline (NA) produced responses in bisected rat vas deferens which mimicked the biphasic responses to nerve stimulation, and these actions were modified by nifedipine and verapamil in a manner similar to the modification of the 2 phases of the responses of the vas to nerve stimulation.	Norepinephrine	35-48	arginine vasopressin	Rattus norvegicus	89-92
6130966-1	1983	Application of exogenous ATP or of noradrenaline (NA) produced responses in bisected rat vas deferens which mimicked the biphasic responses to nerve stimulation, and these actions were modified by nifedipine and verapamil in a manner similar to the modification of the 2 phases of the responses of the vas to nerve stimulation.	Norepinephrine	35-48	arginine vasopressin	Rattus norvegicus	302-305
6186767-4	1983	Ruthenium red (10 microM), known to inhibit Ca2+-entry into mitochondria, enhanced veratrine-induced [3H]noradrenaline release.	Norepinephrine	105-118	carbonic anhydrase 2	Rattus norvegicus	44-47
6303798-1	1983	In the prostatic half of the rat vas deferens, responses to noradrenaline 30 microM were biphasic.	Norepinephrine	60-73	arginine vasopressin	Rattus norvegicus	33-36
6303798-7	1983	It was concluded that the calcium channel inhibitors can distinguish between three distinct types of calcium ion channel in the rat vas deferens: (1) sensitive calcium channels mediating the noradrenaline response in the epididymal half, and the late part of the noradrenaline response in the prostatic half (2) calcium channels responsible for the first phase of the twitch, blocked by high concentrations of nifedipine (3) calcium channels mediating the second phase of the twitch and the initial response to noradrenaline in the prostatic half, unaffected by nifedipine.	Norepinephrine	191-204	arginine vasopressin	Rattus norvegicus	132-135
6130707-3	1983	A pressor dose of ANG II stimulated an increase in norepinephrine (NE) utilization in the locus coeruleus, raphe magnus and AI regions of the brain stem, and in the hypothalamus.	Norepinephrine	51-65	angiotensinogen	Rattus norvegicus	18-24
6841966-1	1983	Norepinephrine concentration of the whole brain was found to be statistically different between the HBP and LBP mouse stains that had been selectively bred for high and low systolic blood pressure, respectively.	Norepinephrine	0-14	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	Mus musculus	100-103
6300645-5	1983	Norepinephrine, phenylephrine, and other alpha-adrenergic agonists produced dose-dependent contractions of whole vas deferens in vitro.	Norepinephrine	0-14	arginine vasopressin	Rattus norvegicus	113-116
6300645-11	1983	The results suggest that rat vas deferens contains a homogeneous population of alpha 1-adrenergic receptors mediating the contractile response to norepinephrine, that these receptors can be directly labeled with 125IBE, and that there may be a nonlinear relationship between agonist occupancy of alpha 1-adrenergic receptors and the functional response of this tissue.	Norepinephrine	146-160	arginine vasopressin	Rattus norvegicus	29-32
6824696-5	1983	These results suggest that dopamine, norepinephrine and epinephrine may serve as physiological regulators of mammalian dihydropteridine reductase.	Norepinephrine	37-51	quinoid dihydropteridine reductase	Homo sapiens	119-145
6339003-2	1983	Systemic or intraventricular administration of insulin had no effect on catecholamine levels, but increased the turnover rate of norepinephrine and epinephrine.	Norepinephrine	129-143	insulin	Homo sapiens	47-54
6339003-3	1983	Insulin induced a dose-related increased release of norepinephrine, epinephrine and dopamine from hypothalamic slices.	Norepinephrine	52-66	insulin	Homo sapiens	0-7
6318517-0	1983	In vivo effect of noradrenaline on the cyclic AMP level in rat corpora lutea.	Norepinephrine	18-31	transmembrane serine protease 5	Rattus norvegicus	46-49
6337508-7	1983	Norepinephrine (250 ng/min) slightly enhanced the pressor responsiveness to the smaller doses of lysine-vasopressin.	Norepinephrine	0-14	arginine vasopressin	Rattus norvegicus	104-115
6409409-3	1983	Noradrenaline (0.5 micrograms X kg-1 X min-1) caused a fall in ventricular fibrillation threshold from 30 to 20 mA (P less than 0.001).	Norepinephrine	0-13	CD59 molecule (CD59 blood group)	Homo sapiens	39-44
6351521-4	1983	It was found that insulin, but not modified sham feeding, caused a marked increase in plasma adrenaline and noradrenaline concentrations whereas gastric acid secretion was of a similar magnitude in the two tests.	Norepinephrine	108-121	insulin	Homo sapiens	18-25
6318517-1	1983	Under in vitro conditions adrenaline and noradrenaline can stimulate the production of cyclic AMP in rat corpora lutea to a similar extent as a maximal dose of LH.	Norepinephrine	41-54	transmembrane serine protease 5	Rattus norvegicus	94-97
6624492-1	1983	Vascular reactivity to noradrenaline after angiotensin II and saralasin administration has been studied in vitro on isolated arterial vessels (aorta and mesenteric artery strips) of two strains of normotensive rats and spontaneously hypertensive rats.	Norepinephrine	23-36	angiotensinogen	Rattus norvegicus	43-57
6297962-1	1983	It has been shown in experiments on rat vas deferens that melipramine, harmane and 3-methylharman in low concentrations of the order of 10(-8)--10(-6) M increase the contraction of the vas deference induced by noradrenaline and transmural stimulation.	Norepinephrine	210-223	arginine vasopressin	Rattus norvegicus	185-188
6624492-4	1983	The potentiated effect of noradrenaline in the presence of angiotensin II is higher on isolated arterial vessels of spontaneously hypertensive rats than on isolated arterial vessels of normotensive rats; 3.	Norepinephrine	26-39	angiotensinogen	Rattus norvegicus	59-73
6624492-5	1983	The potentiated effect of noradrenaline in the presence of angiotensin II was depressed after administration of angiotensin II-blocker.	Norepinephrine	26-39	angiotensinogen	Rattus norvegicus	59-73
6624492-5	1983	The potentiated effect of noradrenaline in the presence of angiotensin II was depressed after administration of angiotensin II-blocker.	Norepinephrine	26-39	angiotensinogen	Rattus norvegicus	112-126
6301307-4	1983	Beta 1- and beta 2-responses were expressed as the increments of cyclic AMP content of 10(6) lymphocytes incubated with norepinephrine (beta 1-stimulant) and salbutamol (beta 2-stimulant).	Norepinephrine	120-134	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	0-6
6301307-4	1983	Beta 1- and beta 2-responses were expressed as the increments of cyclic AMP content of 10(6) lymphocytes incubated with norepinephrine (beta 1-stimulant) and salbutamol (beta 2-stimulant).	Norepinephrine	120-134	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	136-142
6850799-5	1983	However, the effect of aMT varies with the presence of noradrenaline (NA) in the medium and is not identical in both species.	Norepinephrine	55-68	aminomethyltransferase	Rattus norvegicus	23-26
6839553-15	1983	It is concluded that part of the phasic component of the response to KCl in the rat vas deferens is due to the release of noradrenaline from intramural nerves.	Norepinephrine	122-135	arginine vasopressin	Rattus norvegicus	84-87
6317800-4	1983	Moreover, by itself, ACTH treatment alters the ability of norepinephrine to stimulate cAMP accumulation in brain tissue without affecting recognition site number.	Norepinephrine	58-72	proopiomelanocortin	Homo sapiens	21-25
6299918-4	1983	The pre-existing paradoxical ACTH response of patients with Cushing"s disease after adrenalectomy was abolished after depletion of norepinephrine granules by means of reserpine.	Norepinephrine	131-145	proopiomelanocortin	Homo sapiens	29-33
6663301-2	1983	In cultured mouse pinealocytes prolactin stimulates protein/peptide secretion, characterized by the formation of granular vesicles (GV), in the presence of noradrenaline.	Norepinephrine	156-169	prolactin	Rattus norvegicus	31-40
6663301-3	1983	Prolactin also stimulates this secretion in rat pinealocytes, but only when the hormone was added to a noradrenaline-free medium.	Norepinephrine	103-116	prolactin	Rattus norvegicus	0-9
6663301-5	1983	In cultured rat pinealocytes prolactin, in the presence of noradrenaline, strongly stimulates the ependymal-like protein/peptide secretory process.	Norepinephrine	59-72	prolactin	Rattus norvegicus	29-38
6319593-3	1983	Drugs (isoproterenol, norepinephrine, or propranolol) known to influence pineal gland NAT activity by acting directly on pinealocyte postsynaptic beta-noradrenoceptors produced comparable changes in enzyme activity at all ages studied, although larger doses of the receptor agonist were required in fetal animals to elevate NAT activity.	Norepinephrine	22-36	N-acetyltransferase 1	Rattus norvegicus	86-89
6674655-5	1983	The adrenomedullary hormone signaling the presence of adrenomedullary activity to the vasopressin releasing mechanism was identified as noradrenaline and not adrenaline.	Norepinephrine	136-149	arginine vasopressin	Rattus norvegicus	86-97
6306616-5	1983	In contrast, simultaneous intracisternal administration of the angiotensin II antagonist, [Sar1, Val5, Ala8]-angiotensin II (saralasin), 1.1 nmol together with beta-endorphin, blunted the plasma epinephrine, norepinephrine and dopamine responses to beta-endorphin.	Norepinephrine	208-222	angiotensinogen	Homo sapiens	63-77
6369000-12	1983	In isolated veins contracted with norepinephrine, thrombin and arachidonic acid cause increases in tension which are abolished by endothelium removal.	Norepinephrine	34-48	coagulation factor II, thrombin	Homo sapiens	50-58
6306616-4	1983	Simultaneous intracisternal administration of angiotensin II 1.0 nmol together with synthetic human beta-endorphin 1.45 nmol potentiated the plasma epinephrine, norepinephrine and dopamine responses to intracisternal beta-endorphin.	Norepinephrine	161-175	angiotensinogen	Homo sapiens	46-60
6306616-4	1983	Simultaneous intracisternal administration of angiotensin II 1.0 nmol together with synthetic human beta-endorphin 1.45 nmol potentiated the plasma epinephrine, norepinephrine and dopamine responses to intracisternal beta-endorphin.	Norepinephrine	161-175	proopiomelanocortin	Homo sapiens	100-114
6306616-5	1983	In contrast, simultaneous intracisternal administration of the angiotensin II antagonist, [Sar1, Val5, Ala8]-angiotensin II (saralasin), 1.1 nmol together with beta-endorphin, blunted the plasma epinephrine, norepinephrine and dopamine responses to beta-endorphin.	Norepinephrine	208-222	angiotensinogen	Homo sapiens	109-123
6857183-0	1983	Signalled and unsignalled avoidance impairments following noradrenaline depletion with DSP4: an hypothesis incorporating an associative and a non-associative factor.	Norepinephrine	58-71	dual specificity phosphatase 26	Homo sapiens	87-91
6755251-2	1982	There was also a significant positive correlation between plasma levels of norepinephrine and arginine vasopressin after the water load, as well as a negative correlation between plasma norepinephrine and the percentage of the load excreted.	Norepinephrine	75-89	arginine vasopressin	Homo sapiens	103-114
6755251-3	1982	A positive correlation between plasma norepinephrine and plasma renin activity, as well as between norepinephrine and aldosterone, was observed.	Norepinephrine	38-52	renin	Homo sapiens	64-69
6129126-3	1982	Norepinephrine, epinephrine and clonidine, but not methoxamine and phenylephrine inhibited ACTH secretion.	Norepinephrine	0-14	proopiomelanocortin	Canis lupus familiaris	91-95
6129902-12	1982	Analysis of the relationship between norepinephrine metabolism and tyrosine 3-monooxygenase activity indicates that the apparent Ki of this enzyme for norepinephrine in intact cells is 10-15-times the basal cytoplasmic concentration of norepinephrine, or approx.	Norepinephrine	37-51	tyrosine hydroxylase	Homo sapiens	67-91
6129902-12	1982	Analysis of the relationship between norepinephrine metabolism and tyrosine 3-monooxygenase activity indicates that the apparent Ki of this enzyme for norepinephrine in intact cells is 10-15-times the basal cytoplasmic concentration of norepinephrine, or approx.	Norepinephrine	151-165	tyrosine hydroxylase	Homo sapiens	67-91
6129902-12	1982	Analysis of the relationship between norepinephrine metabolism and tyrosine 3-monooxygenase activity indicates that the apparent Ki of this enzyme for norepinephrine in intact cells is 10-15-times the basal cytoplasmic concentration of norepinephrine, or approx.	Norepinephrine	151-165	tyrosine hydroxylase	Homo sapiens	67-91
6188430-0	1982	Angiotensin II-norepinephrine relationship in the central nervous system.	Norepinephrine	15-29	angiotensinogen	Rattus norvegicus	0-14
6128020-3	1982	3 Noradrenaline 5.0 micrograms min-1 and isoprenaline 1.0 microgram min-1 significantly increased ventilation and CO2 production and decreased alveolar PCO2.	Norepinephrine	2-15	CD59 molecule (CD59 blood group)	Homo sapiens	31-57
6129681-3	1982	After washing, these cells retained their sensitivity and secreted growth hormone (GH) in response to physiological activators (norepinephrine, dopamine, serotonin) or inhibitors (somatostatin) as well as pharmacological activators (PGE2).	Norepinephrine	128-142	growth hormone 1	Homo sapiens	67-81
6129681-3	1982	After washing, these cells retained their sensitivity and secreted growth hormone (GH) in response to physiological activators (norepinephrine, dopamine, serotonin) or inhibitors (somatostatin) as well as pharmacological activators (PGE2).	Norepinephrine	128-142	growth hormone 1	Homo sapiens	83-85
6291687-0	1982	Dopamine acts at the same receptors as noradrenaline in the rat isolated vas deferens.	Norepinephrine	39-52	arginine vasopressin	Rattus norvegicus	73-76
6291687-6	1982	3 In experiments using the prostatic half of the rat vas deferens, in the presence of cocaine, oestradiol, propranolol and prazosin, noradrenaline was approximately 40 times more potent than dopamine in causing inhibition of twitches induced by electrical field stimulation.	Norepinephrine	133-146	arginine vasopressin	Rattus norvegicus	53-56
6290242-1	1982	The effect of the alpha 2-receptor antagonist, yohimbine on norepinephrine overflow was studied in the transmural-stimulated isolated rat vas deferens.	Norepinephrine	60-74	arginine vasopressin	Rattus norvegicus	138-141
6290242-4	1982	These results were found to be due to the electrolytic O-demethylation of normetanephrine with the resultant generation of large quantities of norepinephrine obscuring the influence of yohimbine on nerve-stimulated norepinephrine overflow from the vas deferens.	Norepinephrine	143-157	arginine vasopressin	Rattus norvegicus	248-251
6290242-7	1982	This report demonstrates utilization of a radioenzymatic assay to study endogenous norepinephrine overflow from rat vas deferens.	Norepinephrine	83-97	arginine vasopressin	Rattus norvegicus	116-119
7132559-7	1982	From these results it may be concluded that a fully extended side chain conformation is required for NMT substrate activity, and the better substrate activity for 6,7-D2HX compared to 4 is consistent with a proper catechol orientation for interaction with the norepinephrine (NE) binding site of NMT.	Norepinephrine	260-274	N-myristoyltransferase 1	Homo sapiens	296-299
7176332-1	1982	The cardiovascular pressor responsiveness to infused norepinephrine (NE) or angiotensin II (AII) as related to endogenous plasma NE or renin levels was assessed in 20 patients with mild parenchymal kidney disease (plasma creatinine 2.20 +/- 0.58 mg/dl, +/- SEM) and in 20 normal subjects approximately matched for sex and age.	Norepinephrine	53-67	renin	Homo sapiens	135-140
6821183-0	1982	Effect of intraperitoneally injected lysine vasopressin on noradrenaline turnover in certain brain regions of the rat.	Norepinephrine	59-72	arginine vasopressin	Rattus norvegicus	44-55
7049676-1	1982	Corticotropin-releasing factor (CRF) injected into the brains of rats produces hyperglycemia and an increase in plasma concentrations of glucagon, epinephrine, and norepinephrine.	Norepinephrine	164-178	corticotropin releasing hormone	Rattus norvegicus	0-30
6756553-10	1982	These observations confirm our earlier reports, in rat hypothalamus, that the norepinephrine innervation of the hypothalamic magnocellular neurons as seen with catecholamine histofluorescence favors the vasopressin-containing neurons over those located within the same nuclei which synthesize another neurohyphysial principal, oxytocin.	Norepinephrine	78-92	arginine vasopressin	Rattus norvegicus	203-214
7172047-5	1982	Norepinephrine levels in vas deferens were reduced after constant light and increased after constant darkness, compared to light/dark conditions.	Norepinephrine	0-14	arginine vasopressin	Rattus norvegicus	25-28
7172047-6	1982	It is concluded that norepinephrine only in tissues innervated from the superior cervical sympathetic ganglia is influenced by external light stimuli, and that the norepinephrine changes in vas deferens are secondary effects of the hormonal alterations produced by continuous light and darkness, respectively, and affecting the entire reproductive tract.	Norepinephrine	164-178	arginine vasopressin	Rattus norvegicus	190-193
6282573-4	1982	When dopamine receptors were blocked with domperidone, PRL secretion was also stimulated by l-epinephrine (E) and l-norepinephrine (NE), the rank order of potency being l-ISO greater than E much greater than NE.	Norepinephrine	114-130	prolactin	Homo sapiens	55-58
6290726-1	1982	Studies were made on developmental changes in phasic contractions of isolated rat vas deferens in response to norepinephrine (NE) and acetylcholine (ACh), which are mediated by alpha-adrenergic and muscarinic cholinergic receptors (alpha-R and m-R).	Norepinephrine	110-124	arginine vasopressin	Rattus norvegicus	82-85
6751813-6	1982	Peak levels of norepinephrine (228.9 +/- 36.0 ng/l) and epinephrine (720.6 +/- 125.6 ng/l) are observed at 30 and 45 min, those of cAMP (33.4 +/- 2.5 pmol/ml), glucagon (0.209 +/- 0.024 ng/ml), ACTH (166.0 +/- 40.1 ng/ml), and prolactin (28.1 +/- 7.8 ng/ml) at 45 min and finally those of cortisol (26.1 +/- 3.3 micrograms/100 ml) and growth hormone (21.6 +/- 3.1 ng/ml) at 60 min following insulin injection.	Norepinephrine	15-29	proopiomelanocortin	Homo sapiens	194-198
6751813-6	1982	Peak levels of norepinephrine (228.9 +/- 36.0 ng/l) and epinephrine (720.6 +/- 125.6 ng/l) are observed at 30 and 45 min, those of cAMP (33.4 +/- 2.5 pmol/ml), glucagon (0.209 +/- 0.024 ng/ml), ACTH (166.0 +/- 40.1 ng/ml), and prolactin (28.1 +/- 7.8 ng/ml) at 45 min and finally those of cortisol (26.1 +/- 3.3 micrograms/100 ml) and growth hormone (21.6 +/- 3.1 ng/ml) at 60 min following insulin injection.	Norepinephrine	15-29	insulin	Homo sapiens	391-398
7084115-1	1982	Evidence is presented indicating that norepinephrine (NE) inhibits vasopressin (VP) release from the rat hypothalamo-neurohypophyseal explant under some, but not all, conditions in vitro.	Norepinephrine	38-52	arginine vasopressin	Rattus norvegicus	67-78
6752473-4	1982	Plasma norepinephrine (P-NE) levels increased in proportion to the severity of CHF (p less than 0.001) and had a positive correlation with systemic vascular resistance (SVR) (p less than 0.01), VP (p less than 0.05), pulmonary artery wedge pressure (PWP) (p less than 0.01) and plasma renin activity (PRA) (p less than 0.01).	Norepinephrine	7-21	renin	Homo sapiens	285-290
6752474-5	1982	There is a positive correlation between plasma norepinephrine and active plasma renin during graded exercise (r = 0.916, p less than 0.01).	Norepinephrine	47-61	renin	Homo sapiens	80-85
6809475-1	1982	The pressor response to both angiotensin II (5, 10 and 20 ng kg-1 min-1) and to noradrenaline (50, 100 and 200 ng kg-1 min-1) was reduced (P less than 0.05 to less than 0.005) in six healthy male subjects following the administration of the calcium-antagonist nifedipine (10 mg p.o.).	Norepinephrine	80-93	CD59 molecule (CD59 blood group)	Homo sapiens	119-124
6293453-0	1982	Attenuation of the context effect and lack of unconditioned stimulus-preexposure effect in taste-aversion learning following treatment with DSP4, the selective noradrenaline neurotoxin.	Norepinephrine	160-173	dual specificity phosphatase 26	Homo sapiens	140-144
6123583-7	1982	These results are consistent with the hypothesis that monensin causes the release of norepinephrine from chromaffin granules into the cytoplasm of pheochromocytoma cells and that the increase in cytoplasmic norepinephrine inhibits tyrosine 3-monooxygenase activity.	Norepinephrine	207-221	tyrosine hydroxylase	Homo sapiens	231-255
7081446-4	1982	The response to quick stretch in Ca2+-free solution was enhanced by norepinephrine or histamine but was not affected by high K+ (40-100 mM), verapamil, or nifedipine.	Norepinephrine	68-82	carbonic anhydrase 2	Oryctolagus cuniculus	33-36
6281410-3	1982	Perfusion of spleens with Met-enkephalin (10(-8)-10(-5) M) produced a dose-dependent decrease in the release of endogenous norepinephrine upon nerve stimulation.	Norepinephrine	123-137	proopiomelanocortin	Homo sapiens	26-40
7043177-4	1982	The injection of insulin increased the plasma levels of epinephrine (E) and norepinephrine (NE) in both groups of subjects, but the raise in E was greater in the trained subjects.	Norepinephrine	76-90	insulin	Homo sapiens	17-24
6281410-9	1982	These findings support the hypothesis that the opiate receptor population in peripheral tissues are heterogenous and that Met-enkephalin depresses exocytotic release of norepinephrine by interacting with a specific presynaptic opiate receptor.	Norepinephrine	169-183	proopiomelanocortin	Homo sapiens	122-136
6805511-2	1982	Norepinephrine- and Ca2+-stimulated phosphate incorporation was diminished in ghosts depleted of calmodulin.	Norepinephrine	0-14	calmodulin 1	Homo sapiens	97-107
6126864-3	1982	Release of LHRH, somatostatin and vasopressin is affected by a variety of neurotransmitters or neuromodulators, such as norepinephrine, dopamine, epinephrine, histamine, cholinergic and opioid agonists, and peptides such as angiotensin II.	Norepinephrine	120-134	arginine vasopressin	Homo sapiens	34-45
6126864-3	1982	Release of LHRH, somatostatin and vasopressin is affected by a variety of neurotransmitters or neuromodulators, such as norepinephrine, dopamine, epinephrine, histamine, cholinergic and opioid agonists, and peptides such as angiotensin II.	Norepinephrine	120-134	angiotensinogen	Homo sapiens	224-238
7041592-13	1982	These results suggest that the attenuation by captopril of the pressor responses to norepinephrine and vasopressin might have been due to reduction of endogenous angiotensin II.	Norepinephrine	84-98	angiotensinogen	Homo sapiens	162-176
6805511-3	1982	Ghosts prepared with endogenous calmodulin showed Ca2+- and norepinephrine-stimulated protein phosphorylation only when the ghosts had been resealed in the presence of (gamma-32P)ATP.	Norepinephrine	60-74	calmodulin 1	Homo sapiens	32-42
6805511-5	1982	These observations suggest that Ca2+ and norepinephrine stimulation of membrane protein phosphorylation is mediated by calmodulin-dependent spectrin kinase activity, and not by increased turnover of spectrin ATPase or by inhibition of phosphospectrin phosphatase.	Norepinephrine	41-55	calmodulin 1	Homo sapiens	119-129
6288548-2	1982	The addition of 5% rat serum to these cultures resulted in stimulation of NAT activity equal to that obtained with optimal concentrations of the adrenergic agonist norepinephrine (NE).	Norepinephrine	164-178	N-acetyltransferase 1	Rattus norvegicus	74-77
6278133-5	1982	Angiotensin II also potentiated the pressor response to exogenously administered norepinephrine (NE, 50 ng) in both WKY and SHR.	Norepinephrine	81-95	angiotensinogen	Rattus norvegicus	0-14
6122590-0	1982	Effects of alpha-adrenoceptor agents on norepinephrine release from vas deferens of several species including man.	Norepinephrine	40-54	arginine vasopressin	Rattus norvegicus	68-71
6288910-4	1982	When the rat vas deferens was incubated with l-norepinephrine 10(-4) for 3 min, the cyclic GMP level in the vas deferens denervated for seven d was significantly higher than that in the intact specimen, and the cyclic AMP level in the intact one was almost the same as in the denervated preparation.	Norepinephrine	45-61	arginine vasopressin	Rattus norvegicus	13-16
6288910-4	1982	When the rat vas deferens was incubated with l-norepinephrine 10(-4) for 3 min, the cyclic GMP level in the vas deferens denervated for seven d was significantly higher than that in the intact specimen, and the cyclic AMP level in the intact one was almost the same as in the denervated preparation.	Norepinephrine	45-61	arginine vasopressin	Rattus norvegicus	108-111
7048470-0	1982	[Plasma noradrenaline concentration in essential hypertension-with particular references to age, plasma renin activity and spontaneous fall of blood pressure (author"s transl)].	Norepinephrine	8-21	renin	Homo sapiens	104-109
6122590-3	1982	The results indicate that, even though presynaptic alpha-adrenoceptors exist, a negative feedback regulation of release by norepinephrine, which occurs in the vas deferens of the other species, may not be functionally important in the vas deferens of the human.	Norepinephrine	123-137	arginine vasopressin	Rattus norvegicus	159-162
6124065-4	1982	In diseases of the heart in rest and under load above all the noradrenalin-serum-concentration is increased (NA = alpha-beta 1-stimulator), a prevalent blocking of beta 1-receptors justifies the above mentioned therapeutical aim in these patients.	Norepinephrine	62-74	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	120-126
6279235-3	1982	These results indicate that angiotensin converting enzyme in the pineal gland is under negative control by the norepinephrine released from pineal sympathetic nerves.	Norepinephrine	111-125	angiotensin I converting enzyme	Rattus norvegicus	28-57
6124065-4	1982	In diseases of the heart in rest and under load above all the noradrenalin-serum-concentration is increased (NA = alpha-beta 1-stimulator), a prevalent blocking of beta 1-receptors justifies the above mentioned therapeutical aim in these patients.	Norepinephrine	62-74	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	164-170
7040226-0	1982	Effect of inhibition of angiotensin II with captopril on renal overflow of norepinephrine.	Norepinephrine	75-89	angiotensinogen	Homo sapiens	24-38
7042427-0	1982	Insulin absorption from the abdomen and the thigh in healthy subjects during rest and exercise: blood glucose, plasma insulin, growth hormone, adrenaline and noradrenaline levels.	Norepinephrine	158-171	insulin	Homo sapiens	0-7
6130933-4	1982	Careful examination of catecholamine synthesizing enzyme specific activities and catecholamine concentrations in nerve growth factor-treated SY5Y cells showed a small elevation of tyrosine hydroxylase, no change in dopamine-beta-hydroxylase or in dopamine or norepinephrine intracellular concentrations.	Norepinephrine	259-273	nerve growth factor	Homo sapiens	113-132
6280799-5	1982	3 alpha-MSH dose-response curves were shifted, in parallel, to the right in the presence of the catecholamines, noradrenaline, adrenaline and dopamine, and Lineweaver-Burke plots and Arunlakshana-Schild plots indicated that the catecholamines antagonized MSH action by a competitive mechanism.	Norepinephrine	112-125	proopiomelanocortin	Homo sapiens	2-11
7162634-8	1982	However, pretreatment of the rabbits with monofluoromethyldopa, an irreversible inhibitor of DOPA decarboxylase, transformed the biexponential decline of noradrenaline overflow into a monoexponential one with the same rate constant as that of dopamine beta-hydroxylase overflow.	Norepinephrine	154-167	dopamine beta-hydroxylase	Oryctolagus cuniculus	243-268
6176786-2	1982	In a pithed rat preparation the vasoconstrictor responses to both nerve stimulation (1-30 Hz) and exogenous noradrenaline (10-500 ng) were reduced by the ACE inhibitors captopril (0.1 and 1 mg/kg) and SQ20881 (10 mg/kg), and by the angiotensin II antagonist [Sar1 Ala8]angiotensin II (4 micrograms/kg/min).	Norepinephrine	108-121	angiotensin I converting enzyme	Rattus norvegicus	154-157
6176786-2	1982	In a pithed rat preparation the vasoconstrictor responses to both nerve stimulation (1-30 Hz) and exogenous noradrenaline (10-500 ng) were reduced by the ACE inhibitors captopril (0.1 and 1 mg/kg) and SQ20881 (10 mg/kg), and by the angiotensin II antagonist [Sar1 Ala8]angiotensin II (4 micrograms/kg/min).	Norepinephrine	108-121	angiotensinogen	Rattus norvegicus	232-246
6176786-2	1982	In a pithed rat preparation the vasoconstrictor responses to both nerve stimulation (1-30 Hz) and exogenous noradrenaline (10-500 ng) were reduced by the ACE inhibitors captopril (0.1 and 1 mg/kg) and SQ20881 (10 mg/kg), and by the angiotensin II antagonist [Sar1 Ala8]angiotensin II (4 micrograms/kg/min).	Norepinephrine	108-121	angiotensinogen	Rattus norvegicus	259-283
7121636-0	1982	[Effect of noradrenaline and serotonin on responses of field CA3 neurons of hippocampal slices evoked by electric stimulation of mossy fibers].	Norepinephrine	11-24	carbonic anhydrase 3	Homo sapiens	61-64
7162634-14	1982	Under the conditions of repeated stimulation and prolonged action potentials, the only factor interfering with the stoichiometry of noradrenaline and dopamine beta-hydroxylase release is the re-synthesis of noradrenaline.	Norepinephrine	207-220	dopamine beta-hydroxylase	Oryctolagus cuniculus	150-175
7333359-2	1981	Rat prolactin produces in a dose of 100 micrograms/kg a rapid and marked increase of dopamine turnover in the medial palisade zone of the median eminence and of noradrenaline turnover in the posterior periventricular hypothalamic region as well as a possible minor increase of noradrenaline turnover in the magnocellular part of the paraventricular hypothalamic nucleus of the hypophysectomized male rat.	Norepinephrine	161-174	prolactin	Rattus norvegicus	4-13
6298888-8	1982	They also support the suggestion that epinephrine and/or norepinephrine could be involved as physiological corticotropin-releasing factor(s).	Norepinephrine	57-71	corticotropin releasing hormone	Rattus norvegicus	107-137
6801733-8	1982	Finally, histochemical studies demonstrated stimulation of uterine catecholamine levels (norepinephrine) by arachidonic acid, PGF2 alpha and bradykinin.	Norepinephrine	89-103	kininogen 1	Homo sapiens	141-151
7187989-0	1982	The role of noradrenaline in learned behaviors: studies using DSP4.	Norepinephrine	12-25	dual specificity phosphatase 26	Homo sapiens	62-66
7308151-6	1981	Results show the presence of an inotropic action of PTH in vitro and suggest that this action of PTH is partially mediated by releasing the endogenous myocardial norepinephrine which exerts a positive inotropic effect via beta-adrenergic stimulation and by an increase in Ca++ influx across plasma membranes, but independent of adenylate cyclase activation.	Norepinephrine	162-176	parathyroid hormone	Rattus norvegicus	52-55
7308151-6	1981	Results show the presence of an inotropic action of PTH in vitro and suggest that this action of PTH is partially mediated by releasing the endogenous myocardial norepinephrine which exerts a positive inotropic effect via beta-adrenergic stimulation and by an increase in Ca++ influx across plasma membranes, but independent of adenylate cyclase activation.	Norepinephrine	162-176	parathyroid hormone	Rattus norvegicus	97-100
7333359-2	1981	Rat prolactin produces in a dose of 100 micrograms/kg a rapid and marked increase of dopamine turnover in the medial palisade zone of the median eminence and of noradrenaline turnover in the posterior periventricular hypothalamic region as well as a possible minor increase of noradrenaline turnover in the magnocellular part of the paraventricular hypothalamic nucleus of the hypophysectomized male rat.	Norepinephrine	277-290	prolactin	Rattus norvegicus	4-13
7343557-6	1981	6 It is suggested that the effect on tritium overflow of blockade of the reuptake of noradrenaline by cocaine is masked in mouse vas deferens by a compensatory process mediated through presynaptic alpha-adrenoreceptors.	Norepinephrine	85-98	arginine vasopressin	Rattus norvegicus	129-132
6275345-4	1981	The noradrenaline content of the duct of the vas deferens was greatly reduced by guanethidine treatment, but almost recovered after 4 months.	Norepinephrine	4-17	arginine vasopressin	Rattus norvegicus	45-48
7036720-0	1981	Sodium intake alters the effects of norepinephrine on the renin system and the kidney.	Norepinephrine	36-50	renin	Homo sapiens	58-63
7298141-1	1981	A part of the vasoconstrictor activity of angiotensin II (AII) may result from its ability to enhance norepinephrine (NE) release from sympathetic noradrenergic nerve terminals.	Norepinephrine	102-116	angiotensinogen	Rattus norvegicus	42-56
7298141-1	1981	A part of the vasoconstrictor activity of angiotensin II (AII) may result from its ability to enhance norepinephrine (NE) release from sympathetic noradrenergic nerve terminals.	Norepinephrine	102-116	angiotensinogen	Rattus norvegicus	58-61
6119400-7	1981	In rat isolated vas deferens, the isotonic contractile response to low doses of noradrenaline were antagonized and those to high does potentiated by raubasine.	Norepinephrine	80-93	arginine vasopressin	Rattus norvegicus	16-19
6119003-6	1981	It is suggested that the preferential increases of noradrenaline turnover in various hypothalamic noradrenaline nerve terminal systems by nicotine may be partly responsible for the nicotine induced increases of serum prolactin.	Norepinephrine	51-64	prolactin	Rattus norvegicus	217-226
6266596-9	1981	The action of ACTH on protein synthesis rate might be mediated by a calcium-dependent release of norepinephrine followed postsynaptically by beta-receptor activation, cAMP production, and stimulation of translation.	Norepinephrine	97-111	proopiomelanocortin	Homo sapiens	14-18
6117623-0	1981	Release of endogenous noradrenaline and 5-hydroxytryptamine from human blood platelets by thrombin.	Norepinephrine	22-35	coagulation factor II, thrombin	Homo sapiens	90-98
6118864-5	1981	The effect of VIP is not mediated by the release of norepinephrine because it is not blocked by the noradrenergic antagonist d-1-propranolol and is still present in mice in which an 85% depletion of norepinephrine was induced by intracisternal 6-hydroxydopamine injections.	Norepinephrine	199-213	vasoactive intestinal polypeptide	Mus musculus	14-17
6118864-8	1981	Given the narrow radial pattern of arborization of the intracortical VIP neuron and the tangential intracortical trajectory of the noradrenergic fibers, these two systems may function in a complementary fashion: VIP regulating energy metabolism locally, within individual columnar modules, and norepinephrine exerting a more global effect that spans adjacent columns.	Norepinephrine	294-308	vasoactive intestinal polypeptide	Mus musculus	212-215
7268440-1	1981	Acetylcholine and bradykinin produced potent relaxation of isolated canine intrapulmonary arteries contracted by serotonin, norepinephrine, or phenylephrine-provided the endothelium was left intact.	Norepinephrine	124-138	kininogen 1	Canis lupus familiaris	18-28
6115571-2	1981	Activation of the sympathetic nervous system, and renin-angiotensin system, and the antidiuretic hormone-vasopressin system can be demonstrated in clinical CHF by increased plasma levels of norepinephrine, renin activity, and arginine vasopressin.	Norepinephrine	190-204	arginine vasopressin	Homo sapiens	105-116
6266691-7	1981	The plasma renin activity increased from 12.6 +/- 5.0 to 29.9 +/- 8.4 ng/ml/hr (p = 0.030) as plasma aldosterone concentration decreased from 30.5 +/- 6.5 to 11.3 4/- 1.2 ng/dl (p = 0.010) and norepinephrine concentrations decreased from 774 +/- 105 to 618 +/- 85 pg/ml (p = 0.020).	Norepinephrine	193-207	renin	Homo sapiens	11-16
6268920-0	1981	Pre- and postsynaptic adrenergic activation by norepinephrine reuptake inhibitors in the field-stimulated rat vas deferens.	Norepinephrine	47-61	arginine vasopressin	Rattus norvegicus	110-113
7021039-6	1981	Mean plasma noradrenaline concentration was higher in initial hypertensive subjects with a high active renin concentration than in those with a normal renin concentration (442 +/- 70 vs 324 +/- 100 pg/ml).	Norepinephrine	12-25	renin	Homo sapiens	103-108
7018642-0	1981	Insulin-induced elevation of hypothalamic norepinephrine turnover persists after glucorestoration unless feeding occurs.	Norepinephrine	42-56	insulin	Homo sapiens	0-7
7021039-6	1981	Mean plasma noradrenaline concentration was higher in initial hypertensive subjects with a high active renin concentration than in those with a normal renin concentration (442 +/- 70 vs 324 +/- 100 pg/ml).	Norepinephrine	12-25	renin	Homo sapiens	151-156
7022106-4	1981	Responsiveness (maximum effect) and sensitivity to insulin were determined under basal induction conditions, since insulin had a bimodal effect on noradrenaline stimulated lipolysis.	Norepinephrine	147-160	insulin	Homo sapiens	115-122
6263592-0	1981	beta-Endorphin-induced stimulation of central sympathetic outflow: beta-endorphin increases plasma concentrations of epinephrine, norepinephrine, and dopamine in rats.	Norepinephrine	130-144	proopiomelanocortin	Homo sapiens	67-81
6263592-1	1981	Intracisternal administration of synthetic human beta-endorphin (0.058-7.25 nmol) in chronically cannulated, conscious, freely moving, adult male rats increased plasma concentrations of epinephrine, norepinephrine, and dopamine in a dose-related manner.	Norepinephrine	199-213	proopiomelanocortin	Homo sapiens	49-63
7236991-1	1981	1 Vesicular noradrenaline stores were compared in the heart, salivary gland and vas deferens of the rat.	Norepinephrine	12-25	arginine vasopressin	Rattus norvegicus	80-83
7030951-5	1981	There was a significant correlation between percent increments in plasma renin activity (PRA) and the rise in plasma norepinephrine (r = 0.68, p less than 0.05) and a close negative correlation between percent increase in PRA and the ratio of fall in mean blood pressure (MAP) per unit of weight loss (r = -0.73, p less than 0.005).	Norepinephrine	117-131	renin	Homo sapiens	73-78
6117667-6	1981	In congestive heart failure, a significant correlation between plasma norepinephrine concentration and increase of lymphocyte cyclic AMP was demonstrated.	Norepinephrine	70-84	adenine phosphoribosyltransferase	Homo sapiens	133-136
7027386-0	1981	[Effects of angiotensin I converting enzyme inhibitor, captopril, on plasma norepinephrine concentration in hypertensive patients (author"s transl)].	Norepinephrine	76-90	angiotensin I converting enzyme	Homo sapiens	12-43
6112047-0	1981	Beta-endorphin-induced increases in plasma epinephrine, norepinephrine and dopamine in rats: inhibition of adrenomedullary response by intracerebral somatostatin.	Norepinephrine	56-70	proopiomelanocortin	Homo sapiens	0-14
6112047-1	1981	Synthetic human beta-endorphin, 7.25 nmol intracisternally, in unanesthetized, freely moving, chronically cannulated, adult male rats increased plasma concentrations of all 3 catecholamines: epinephrine, norepinephrine and dopamine, for the 2 h period studied.	Norepinephrine	204-218	proopiomelanocortin	Homo sapiens	16-30
6112047-3	1981	Acute systemic administration of guanethidine, which decreases norepinephrine release induced by sympathetic nerve stimulation, blunted the plasma norepinephrine response to intracerebral beta-endorphin.	Norepinephrine	63-77	proopiomelanocortin	Homo sapiens	188-202
6112047-3	1981	Acute systemic administration of guanethidine, which decreases norepinephrine release induced by sympathetic nerve stimulation, blunted the plasma norepinephrine response to intracerebral beta-endorphin.	Norepinephrine	147-161	proopiomelanocortin	Homo sapiens	188-202
6112047-4	1981	Thus, it seems likely that in addition to secretion by adrenal medulla a considerable portion of the beta-endorphin-induced increase in norepinephrine is derived from sympathetic nerve endings.	Norepinephrine	136-150	proopiomelanocortin	Homo sapiens	101-115
6112047-5	1981	Simultaneous intracisternal administration of another neuropeptide, somatostatin, together with beta-endorphin markedly inhibited the plasma epinephrine response to beta-endorphin, while decreasing the dopamine and norepinephrine responses to a much lesser degree.	Norepinephrine	215-229	proopiomelanocortin	Homo sapiens	96-110
6268006-1	1981	In isolated field stimulated rat vas deferens frequency-response curves were shifted to the right by noradrenaline, dopamine, apomorphine, bromocriptine and nomifensine.	Norepinephrine	101-114	arginine vasopressin	Rattus norvegicus	33-36
7020260-4	1981	Though absolutely normal, noradrenaline in high renin essential hypertension was significantly higher than in low renin essential hypertension; it correlated neither with age nor blood pressure.	Norepinephrine	26-39	renin	Homo sapiens	48-53
6115521-10	1981	With metoprolol, epinephrine increased by 100%, norepinephrine by 50% growth hormone by 60%, and cortisol by 90%, insulin remained unchanged.	Norepinephrine	48-62	growth hormone 1	Homo sapiens	70-84
7204569-9	1981	Marked increases in epinephrine and slight increases in norepinephrine were associated with increases in plasma glucose and renin activity and decreases in plasma potassium.	Norepinephrine	56-70	renin	Homo sapiens	124-129
7204574-8	1981	These data demonstrate that AII-increased intestinal absorption is secondary to the release of norepinephrine from nerve endings in the jejunum and that AII inhibition of absorption is not mediated by the sympathetic nervous system.	Norepinephrine	95-109	angiotensinogen	Rattus norvegicus	28-31
7204574-9	1981	The analog (Sar1 Leu8)-AII is a full agonist in the stimulation of jejunal transport (increased norepinephrine release), but antagonizes the inhibitory response to high doses of AII.	Norepinephrine	96-110	angiotensinogen	Rattus norvegicus	23-26
6111224-4	1981	These results suggest that gastric SRIF-LI secretion is stimulated by a beta-adrenergic mechanism and raise the possibility that gastric somatostatin contributes to the inhibitory effect of norepinephrine on gastric acid secretion.	Norepinephrine	190-204	somatostatin	Rattus norvegicus	137-149
6111731-0	1981	Stimulatory effect of somatostatin on norepinephrine release from rat brain cortex slices.	Norepinephrine	38-52	somatostatin	Rattus norvegicus	22-34
7238669-5	1981	The relaxing effect of bradykinin was investigated after maximal contraction with either prostaglandin F2 alpha, histamine or norepinephrine in 23 specimens.	Norepinephrine	126-140	kininogen 1	Homo sapiens	23-33
6268998-7	1981	A similar blood pressure increase to that induced by the vasopressin injections, when elicited by noradrenaline or angiotensin II i.v., was not followed by an elevation of plasma beta-EI.	Norepinephrine	98-111	arginine vasopressin	Homo sapiens	57-68
7285721-7	1981	The data suggest that angiotensin II increases norepinephrine release during nerve stimulation in mesentery obtained from SD and W rats.	Norepinephrine	47-61	angiotensinogen	Rattus norvegicus	22-36
7286607-0	1981	Influence of noradrenaline and KCl on calcium translocation in rat vas deferens smooth muscle and its subcellular fractions.	Norepinephrine	13-26	arginine vasopressin	Rattus norvegicus	67-70
6259059-2	1981	Angiotensin II in subpressor concentrations (3 ng/ml) potentiated the vasoconstrictor responses to both sympathetic nerve stimulation (NS) and exogenous norepinephrine (NE).	Norepinephrine	153-167	angiotensinogen	Rattus norvegicus	0-14
7228520-0	1981	Binding of noradrenaline to bovine serum albumin.	Norepinephrine	11-24	albumin	Homo sapiens	35-48
6973462-0	1981	Intraventricular administration of vasopressin and oxytocin effects the steady-state levels of serotonin, dopamine and norepinephrine in rat brain.	Norepinephrine	119-133	arginine vasopressin	Rattus norvegicus	35-46
6973462-0	1981	Intraventricular administration of vasopressin and oxytocin effects the steady-state levels of serotonin, dopamine and norepinephrine in rat brain.	Norepinephrine	119-133	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	51-59
6973462-1	1981	The effect of lysine-8-vasopressin (LVP) and oxytocin (OXT) has been studied on the steady-state level of serotonin (5-HT),dopamine(DA) and norepinephrine (NE) in various brain areas four hours after intraventricular microinjection of the neuropeptides.	Norepinephrine	140-154	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	45-53
7300958-0	1981	[Effect of noradrenaline and serotonin on background activity of hippocampal CA3 field neurons in vitro].	Norepinephrine	11-24	carbonic anhydrase 3	Homo sapiens	77-80
6120520-3	1981	Ghosts prepared with endogenous calmodulin or resealed around purified calmodulin exhibit norepinephrine- and Ca+2-stimulated phosphorylation only in the presence of [gamma-32P]-ATP.	Norepinephrine	90-104	calmodulin 1	Homo sapiens	32-42
6120520-3	1981	Ghosts prepared with endogenous calmodulin or resealed around purified calmodulin exhibit norepinephrine- and Ca+2-stimulated phosphorylation only in the presence of [gamma-32P]-ATP.	Norepinephrine	90-104	calmodulin 1	Homo sapiens	71-81
6120520-5	1981	These observations suggest that calcium and norepinephrine stimulation of membrane protein phosphorylation is mediated by calmodulin-dependent spectrin kinase activity, rather than by increased turnover by spectrin ATPase or by inhibition of phosphospectrin phosphatase.	Norepinephrine	44-58	calmodulin 1	Homo sapiens	122-132
7449252-4	1980	The effect of angiotensin II and noradrenaline in lowering renal blood flow was reduced during renal arterial infusion of either bradykinin (10 ng min-1 kg-1) or prostaglandin E2 (4 ng min-1 kg-1).	Norepinephrine	33-46	kininogen 1	Canis lupus familiaris	129-139
7449252-6	1980	Pretreatment of the dogs with an inhibitor of prostaglandin synthesis, sodium meclofenamate (5 mg/kg), blunted the inhibitory action of bradykinin, but not that of prostaglandin E2, on renal vascular reactivity to angiotensin II and noradrenaline.	Norepinephrine	233-246	kininogen 1	Canis lupus familiaris	136-146
7449252-8	1980	These results indicate that bradykinin reduces the renal vasoconstriction induced by angiotensin II and noradrenaline in the dog by a mechanism dependent upon synthesis of prostaglandins.	Norepinephrine	104-117	kininogen 1	Canis lupus familiaris	28-38
7202698-4	1980	The response of the preparation to noradrenalin when the concentration of K+ and/or Ca2+ is different from the physiological one was also studied.	Norepinephrine	35-47	carbonic anhydrase 2	Rattus norvegicus	84-87
7202698-5	1980	The results indicate that the ability of K+ to increase free intracellular Ca2+ concentration is greater than that of noradrenalin; there is an increase in the maximal response to noradrenalin on increasing the external concentration of K+ and/or Ca2+.	Norepinephrine	180-192	carbonic anhydrase 2	Rattus norvegicus	75-78
6265626-2	1980	Noradrenaline was infused into normal resting male subjects for consecutive 20 min periods at 3, 7.5 and 15 microgram min-1.	Norepinephrine	0-13	CD59 molecule (CD59 blood group)	Homo sapiens	118-123
7202698-5	1980	The results indicate that the ability of K+ to increase free intracellular Ca2+ concentration is greater than that of noradrenalin; there is an increase in the maximal response to noradrenalin on increasing the external concentration of K+ and/or Ca2+.	Norepinephrine	180-192	carbonic anhydrase 2	Rattus norvegicus	247-250
6107859-0	1980	Somatostatin selectively inhibits noradrenaline release from hypothalamic neurones.	Norepinephrine	34-47	somatostatin	Rattus norvegicus	0-12
7001086-3	1980	Reduction of the urinary noradrenaline levels by the administration of angiotensin converting enzyme inhibitor (SQ-14225) suggested that the high urinary noradrenaline probably resulted from hyperreninemia which reflected high plasma levels of angiotensin II.	Norepinephrine	25-38	angiotensinogen	Homo sapiens	244-258
7001086-3	1980	Reduction of the urinary noradrenaline levels by the administration of angiotensin converting enzyme inhibitor (SQ-14225) suggested that the high urinary noradrenaline probably resulted from hyperreninemia which reflected high plasma levels of angiotensin II.	Norepinephrine	154-167	angiotensinogen	Homo sapiens	244-258
6255952-0	1980	Effect of norepinephrine and dibutyryl cyclic AMP on S-100 protein level in C6 glioma cells.	Norepinephrine	10-24	S100 calcium binding protein A1	Homo sapiens	53-58
6254640-3	1980	Of five ACTH-responsive adrenocortical adenomas, in contrast, three were stimulated by norepinephrine, two by epinephrine, one by thyroid-stimulating hormone, and one by luteinizing hormone in addition to ACTH, indicating the presence of multiple receptors for hormones other than ACTH and PGE1 in these four tumors.	Norepinephrine	87-101	proopiomelanocortin	Homo sapiens	8-12
6162535-3	1980	When contracted with low concentrations of noradrenaline (between 3.0 x 10(-8) and 3.0 x 10(-7) M), this artery responds to SP (6.5 x 10(-11)-6.5 x 10(-9) M) and bradykinin (BK) (8.1 x 10(-11)-9.1 x 10(-8) M) with relaxations that are proportional to the concentrations of the two peptides.	Norepinephrine	43-56	kininogen 1	Canis lupus familiaris	162-172
6162535-3	1980	When contracted with low concentrations of noradrenaline (between 3.0 x 10(-8) and 3.0 x 10(-7) M), this artery responds to SP (6.5 x 10(-11)-6.5 x 10(-9) M) and bradykinin (BK) (8.1 x 10(-11)-9.1 x 10(-8) M) with relaxations that are proportional to the concentrations of the two peptides.	Norepinephrine	43-56	kininogen 1	Canis lupus familiaris	174-176
6263597-1	1980	The effect of TSH (100mU/ml) and norepinephrine (100 muM) on the cyclic AMP levels was studied in 10 human normal tissues, 10 thyroid adenomas and 4 thyroid carcinomas (3 papillary and 1 follicular).	Norepinephrine	33-47	latexin	Homo sapiens	53-56
7443875-2	1980	Infusions of PGD2 into the superior mesenteric artery significantly dilated the mesenteric vascular bed and inhibited vasoconstrictor responses to sympathetic nerve stimulation and intra-arterial injections of norepinephrine and angiotensin II.	Norepinephrine	210-224	prostaglandin D2 synthase	Homo sapiens	13-17
6773571-4	1980	Trifluoperazine, an inhibitor of the Ca2+-dependent regulatory protein, calmodulin, inhibited phosphorylation stimulation by either norepinephrine or the calcium ionophore.	Norepinephrine	132-146	calmodulin 1	Homo sapiens	72-82
6998868-1	1980	The acute responsiveness of plasma catecholamine, renin (PRA), and aldosterone levels to exogenous norepinephrine was studied under placebo conditions and following renin (PRA), and aldosterone levels to exogenous norepinephrine was studied under placebo conditions and following renin-angiotensin activation by diuretic pretreatment in 25 normal subjects and 34 patients with borderline-to-moderate essential hypertension.	Norepinephrine	99-113	renin	Homo sapiens	50-55
6998868-8	1980	These findings demonstrate that an acute increase in the blood levels of the adrenergic neurotransmittor, norepinephrine, causes mild but distinct stimulation of plasma renin and aldosterone levels.	Norepinephrine	106-120	renin	Homo sapiens	169-174
6998868-9	1980	Renin release in response to exogenous norepinephrine is not enhanced following renin-angiotensin activation by diuretic pretreatment.	Norepinephrine	39-53	renin	Homo sapiens	0-5
6998868-10	1980	The responsiveness of the renin-angiotensin-aldosterone system to an acute norepinephrine input seems to be intact in essential hypertension.	Norepinephrine	75-89	renin	Homo sapiens	26-31
6256482-2	1980	The presence of adenosine deaminase during preincubations largely prevents the loss of adenosine, norepinephrine and histamine responses.	Norepinephrine	98-112	adenosine deaminase	Cavia porcellus	16-35
6256482-4	1980	If adenosine deaminase is not inactivated, responses to norepinephrine are not significant and histamine responses are reduced by 50%.	Norepinephrine	56-70	adenosine deaminase	Cavia porcellus	3-22
6998809-5	1980	The rise in heart rate (16 versus 29 beats/min) and in plasma noradrenaline (from 0.16 to 0.32 ng/ml versus 0.20 to 0.49 ng/ml) was significantly greater in the tilted position after insulin.	Norepinephrine	62-75	insulin	Homo sapiens	183-190
6106694-6	1980	Biochemical analyses of the lesions suggested that loss of VIP action on adenylate cyclase was associated with loss of hypothalamic noradrenaline-containing neurons.	Norepinephrine	132-145	vasoactive intestinal peptide	Rattus norvegicus	59-62
7437638-5	1980	5 Adrenal catecholamine secretion in response to handling or acute cold exposure was normal in DEF-treated rats but the fall in body temperature could be markedly reduced by large intraperitoneal injections of noradrenaline, although not atropine.	Norepinephrine	210-223	UTP25 small subunit processome component	Rattus norvegicus	95-98
6769714-2	1980	Dopamine may be a physiological prolactin inhibiting factor (PIF), while norepinephrine and possibly epinephrine regulate prolactin release at the level of the hypothalamus.	Norepinephrine	73-87	prolactin	Homo sapiens	122-131
7193020-19	1980	Secoverine has no nicotinolytic or antihistaminic activity, a moderate antisterotonic activity, an inhibiting effect on the noradrenaline uptake mechanism of the vas deferens and a marked local anaesthetic activity.	Norepinephrine	124-137	arginine vasopressin	Rattus norvegicus	162-165
6997978-0	1980	Plasma noradrenaline concentration in hypertensive and normotensive forty-year-old individuals: relationship to plasma renin concentration.	Norepinephrine	7-20	renin	Homo sapiens	119-124
7371726-9	1980	The results suggest that Rb+ but not Cs+ can fully substitute for K+ in the rat vas deferens response to norepinephrine and methacholine.	Norepinephrine	105-119	arginine vasopressin	Rattus norvegicus	80-83
6998798-2	1980	--In patients without albuminuria intravenous injection of insulin resulted in changes similar to but less pronounced than those previously observed in short-term diabetics: albumin excretion, plasma noradrenaline and heart rate increased, creatinine excretion decreased significantly.	Norepinephrine	200-213	insulin	Homo sapiens	59-66
7052336-0	1980	A maximum contraction and substantial quantities of tritium can be obtained from tetraethylammonium-treated [3H]-noradrenaline preloaded, rat vas deferens in response to a single electrical shock.	Norepinephrine	113-126	arginine vasopressin	Rattus norvegicus	142-145
7052336-7	1980	4 In the presence of 5 mM TEA, contractions of the vas deferens caused by exogenous noradrenaline were potentiated about 5 fold.	Norepinephrine	84-97	arginine vasopressin	Rattus norvegicus	51-54
6987097-0	1980	[Studies on the blood pressure control mechanism in essential hypertension: the relation of plasma norepinephrine concentrations to plasma renin activity and haemodynamics (author"s transl)].	Norepinephrine	99-113	renin	Homo sapiens	139-144
7353356-8	1980	The increases in blood pressure in response to intravenous infusions of noradrenaline were significantly enhanced during vertebral artery infusions of acetylcholine and angiotensin II, but not of prostaglandin F2 alpha.	Norepinephrine	72-85	angiotensinogen	Homo sapiens	169-183
7353356-9	1980	The bradycardia during noradrenaline infusions was significantly enhanced by angiotensin II alone.	Norepinephrine	23-36	angiotensinogen	Homo sapiens	77-91
7207642-9	1980	The t 1/2 of decline from the maxima were similar to those after PAPETA but the output ratio DBH/noradrenaline was 5 times that after PAPETA.	Norepinephrine	97-110	dopamine beta-hydroxylase	Oryctolagus cuniculus	93-96
6907087-4	1980	Noradrenaline concentrations are also reduced in brain tissue of Mo mice and this reduction is associated with a decrease in the vivo activity of the copper metalloenzyme, dopamine beta-monooxygenase (EC 1.14.17.1).	Norepinephrine	0-13	dopamine beta hydroxylase	Mus musculus	172-199
6245422-6	1980	Both TyA-induced and 5-HT-induced head-twitches were inhibited by dopamine and noradrenaline, while catecholaminergic denervators such as reserpine and 6-hydroxydopamine, and diethyldithiocarbamic acid, a dopamine-beta-hydroxylase inhibitor, increased the TyA response.	Norepinephrine	79-92	dopamine beta hydroxylase	Mus musculus	205-230
6998045-1	1980	Dopamine-beta-hydroxylase (D beta H), a glycoprotein enzyme which converts dopamine into noradrenaline, was purified from C1300 mouse neuroblastoma and used to raise antibodies in rabbits.	Norepinephrine	89-102	dopamine beta hydroxylase	Mus musculus	0-25
396070-0	1979	Plasma noradrenaline concentration in hypertensive and normotensive 40-year-old individuals: relationship to plasma renin concentration.	Norepinephrine	7-20	renin	Homo sapiens	116-121
396070-6	1979	In the hypertensive group a close correlation (r = 0.77, P less than 0.001) was found between plasma noradrenaline and plasma renin concentration after acute stimulation.	Norepinephrine	101-114	renin	Homo sapiens	126-131
526075-3	1979	Responses of the vas deferens to noradrenaline were not so influenced.	Norepinephrine	33-46	arginine vasopressin	Rattus norvegicus	17-20
531079-2	1979	Norepinephrine N-methyltransferase (NMT; the epinephrine-forming enzyme) from pigeon brain had Km values for S-adenosyl-L-methionine and L-norepinephrine of 24 +/- 1 and 101 +/- 4 micrometer, respectively.	Norepinephrine	137-153	N-myristoyltransferase 1	Homo sapiens	36-39
531079-3	1979	The enzyme was inhibited by excess L-norepinephrine and by several arylakylamines that earlier had been identified as NMT inhibitors with the enzyme from mammalian brain and adrenal medulla.	Norepinephrine	35-51	N-myristoyltransferase 1	Homo sapiens	118-121
510363-0	1979	Enhancement by elevated external potassium of the maximal responses to acetylcholine and norepinephrine in the rat vas deferens.	Norepinephrine	89-103	arginine vasopressin	Rattus norvegicus	115-118
509357-1	1979	Incubation of dopamine-4-O-sulfate with purified bovine dopamine-beta-hydroxylase led to the formation of free norepinephrine.	Norepinephrine	111-125	dopamine beta-hydroxylase	Bos taurus	56-81
512062-0	1979	Blood pressure response to norepinephrine infusion in relationship to plasma catecholamines and renin activity in man.	Norepinephrine	27-41	renin	Homo sapiens	96-101
381300-3	1979	Norepinephrine releases Ca2+ from this exchangeable pool and decreases both the fluorescence signal and its subsequent response to A23187.	Norepinephrine	0-14	carbonic anhydrase 2	Rattus norvegicus	24-27
526069-0	1979	Variation of postjunctional natures along the length of the rat vas deferens as a cause of regional difference in the sensitivity to norepinephrine.	Norepinephrine	133-147	arginine vasopressin	Rattus norvegicus	64-67
526069-1	1979	Sensitivity to norepinephrine (expressed as pD2) was different between the prostatic and the epididymal half of the rat vas deferens.	Norepinephrine	15-29	arginine vasopressin	Rattus norvegicus	120-123
526069-7	1979	These results suggest that the difference in the sensitivity to norepinephrine between the prostatic and the epididymal half is due to postjunctional natures varying along the length of the rat vas deferens.	Norepinephrine	64-78	arginine vasopressin	Rattus norvegicus	194-197
509357-2	1979	The production of free norepinephrine was completely inhibited in the presence of 5.6 mM of fusaric acid, an inhibitor of dopamine-beta-hydroxylase.	Norepinephrine	23-37	dopamine beta-hydroxylase	Bos taurus	122-147
499312-2	1979	There was a significant fall (mean +/- SD) in the 24 h urinary excretion of vanillylmandelic acid (15.3 +/- 2.8 to 6.7 +/- 1.9 micronmol) noradrenaline (199.0 +/- 105.8 to 125.2 +/- 43.3 nmol) and plasma renin activity (0.71 +/- 0.47 to 0.40 +/- 0.20 pmol Angio I ml-1 h-1) while the urinary normetadrenaline/noradrenaline ratio increased (10.4 +/- 6.1 to 17.1 +/- 5.1).	Norepinephrine	138-151	renin	Homo sapiens	204-209
501904-6	1979	The infusion of pressor doses of angiotensin II suppressed plasma noradrenaline by the reflex mechanism.	Norepinephrine	66-79	angiotensinogen	Rattus norvegicus	33-47
224071-5	1979	In the thymic tumor cells, norepinephrine, serotonin, and TRH were found to be effective in increasing ACTH secretion and intracellular cAMP levels, whereas biogenic amines, hypothalamic hormones, and gastrointestinal hormones did not affect hormone secretion in the thyroid tumor cells.	Norepinephrine	27-41	proopiomelanocortin	Homo sapiens	103-107
530484-1	1979	In the same brain section stained first for catecholamines and then for acetylcholinesterase (EC 3.1.1.7), it was found that neuronal somata in locus ceruleus containing norepinephrine also contained the cholinergic degradative enzyme.	Norepinephrine	170-184	acetylcholinesterase (Cartwright blood group)	Homo sapiens	72-92
530484-5	1979	Acetylcholinesterase may be associated with cerulear somata and proximal processes containing norepinephrine to inactivate a cholinergic input to that structure.	Norepinephrine	94-108	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
231999-3	1979	Sodium clofibrate (0.42 mM), nicotinic acid (0.42 mM), and insulin (100 microU/mL) were shown to inhibit norepinephrine-stimulated lipolysis in rat and human adipose cells and this inhibition was associated with a reduction in intracellular 3",5"-cyclic AMP levels.	Norepinephrine	105-119	insulin	Homo sapiens	59-66
222624-4	1979	beta-Endorphin, VIP, secretin, and glucagon all produce discrete changes in norepinephrine turnover in various hypothalamic nuclei.	Norepinephrine	76-90	vasoactive intestinal peptide	Rattus norvegicus	16-19
508001-6	1979	Guanethidine induced supersensitivity of the vas to noradrenaline and further enhanced the potentiating effect of nomifensine.	Norepinephrine	52-65	arginine vasopressin	Rattus norvegicus	45-48
475507-4	1979	Vas deferentia from reserpinized animals showed reduced contractions upon electrical stimulation but became supersensitive to dopamine and noradrenaline.	Norepinephrine	139-152	arginine vasopressin	Rattus norvegicus	0-3
467493-4	1979	The contractile effect of norepinephrine in unstimulated rat vas deferens was not altered by SS.	Norepinephrine	26-40	arginine vasopressin	Rattus norvegicus	61-64
467493-6	1979	The interaction between SS and its receptors may provoke a decreased diffusion of Ca2+ ions into the nerve terminals and/or a decreased mobilisation of Ca2+ ions from intraneuronal stores thus leading to a reduction in electrically evoked release of norepinephrine.	Norepinephrine	250-264	somatostatin	Rattus norvegicus	24-26
466869-4	1979	Dopamine was three to five times as potent as noradrenaline on the rat vas deferens, but was considerably less potent than noradrenaline on the guinea-pig vas deferens.	Norepinephrine	46-59	arginine vasopressin	Rattus norvegicus	71-74
466869-4	1979	Dopamine was three to five times as potent as noradrenaline on the rat vas deferens, but was considerably less potent than noradrenaline on the guinea-pig vas deferens.	Norepinephrine	123-136	arginine vasopressin	Rattus norvegicus	155-158
466869-7	1979	On the rat vas deferens the pA2 values against noradrenaline and dopamine were 7.6 and 7.4, respectively.	Norepinephrine	47-60	arginine vasopressin	Rattus norvegicus	11-14
38334-9	1979	Acetylcholine-induced increases in hypothalamic CRH production were reduced by GABA, noradrenaline, adrenaline, methoxamine and phenylephrine but not by isoprenaline.	Norepinephrine	85-98	corticotropin releasing hormone	Rattus norvegicus	48-51
38759-0	1979	Potentiation of the response of rat vas deferens to noradrenaline by dicylohexylamine and related amines.	Norepinephrine	52-65	arginine vasopressin	Rattus norvegicus	36-39
38759-1	1979	The results of a previous study on protection by propranolol and dicyclohexylamine of alpha-blockade suggested that these compounds potentiated the response of the isolated rat vas deferens to noradrenaline.	Norepinephrine	193-206	arginine vasopressin	Rattus norvegicus	177-180
217278-2	1979	Angiotensin II potentiated vasoconstrictor responses to both sympathetic nerve stimulation and to exogenous norepinephrine, whereas AIII and [des-Asp1-Arg2]AII potentiated vasoconstrictor responses to exogenous norepinephrine only.	Norepinephrine	108-122	angiotensinogen	Rattus norvegicus	0-14
222025-3	1979	Exogenous cyclic 3",5"-AMP (cAMP) and substances known to increase the intracellular concentration of this nucleotide (isoproterenol, theophylline, noradrenaline, lactate) were shown to inhibit the transport of fluorescein (a weak organic acid) into the rat renal proximal tubules at 20 degrees C. Carbacholine decreasing intracellular cAMP concentration stimulated the transport.	Norepinephrine	148-161	cathelicidin antimicrobial peptide	Rattus norvegicus	10-26
217278-2	1979	Angiotensin II potentiated vasoconstrictor responses to both sympathetic nerve stimulation and to exogenous norepinephrine, whereas AIII and [des-Asp1-Arg2]AII potentiated vasoconstrictor responses to exogenous norepinephrine only.	Norepinephrine	211-225	angiotensinogen	Rattus norvegicus	132-135
217278-3	1979	When the responses to exogenous norepinephrine were compared, the order of agonist potency was AIII greater than AII greater than [des-Asp1-Arg2]AII.	Norepinephrine	32-46	angiotensinogen	Rattus norvegicus	95-98
217278-3	1979	When the responses to exogenous norepinephrine were compared, the order of agonist potency was AIII greater than AII greater than [des-Asp1-Arg2]AII.	Norepinephrine	32-46	angiotensinogen	Rattus norvegicus	113-116
217278-5	1979	The potentiation of exogenous norepinephrine by AII, AIII, and [des-Asp1-Arg2]AII was inhibited by [Sar1-Ile8]AII (110%, 113%, and 108%, respectively) and by [Ile7]AIII (50%, 64%, 91%, respectively).	Norepinephrine	30-44	angiotensinogen	Rattus norvegicus	48-51
217278-5	1979	The potentiation of exogenous norepinephrine by AII, AIII, and [des-Asp1-Arg2]AII was inhibited by [Sar1-Ile8]AII (110%, 113%, and 108%, respectively) and by [Ile7]AIII (50%, 64%, 91%, respectively).	Norepinephrine	30-44	angiotensinogen	Rattus norvegicus	53-56
217278-5	1979	The potentiation of exogenous norepinephrine by AII, AIII, and [des-Asp1-Arg2]AII was inhibited by [Sar1-Ile8]AII (110%, 113%, and 108%, respectively) and by [Ile7]AIII (50%, 64%, 91%, respectively).	Norepinephrine	30-44	angiotensinogen	Rattus norvegicus	53-56
217278-6	1979	We conclude that AII possesses the capacity both to increase norpinephrine release during sympathetic nerve stimulation and to decrease norepinephrine reuptake, whereas AIII and [des-Asp1-Arg2]AII decrease norepinephrine release and reuptake.	Norepinephrine	136-150	angiotensinogen	Rattus norvegicus	17-20
217278-6	1979	We conclude that AII possesses the capacity both to increase norpinephrine release during sympathetic nerve stimulation and to decrease norepinephrine reuptake, whereas AIII and [des-Asp1-Arg2]AII decrease norepinephrine release and reuptake.	Norepinephrine	206-220	angiotensinogen	Rattus norvegicus	17-20
217278-6	1979	We conclude that AII possesses the capacity both to increase norpinephrine release during sympathetic nerve stimulation and to decrease norepinephrine reuptake, whereas AIII and [des-Asp1-Arg2]AII decrease norepinephrine release and reuptake.	Norepinephrine	206-220	angiotensinogen	Rattus norvegicus	169-172
217278-7	1979	Also, under conditions of increased N-terminal degradation of AII, blockade of norepinephrine reuptake would be increased while the release of norepinephrine by nerve stimulation would be reduced.	Norepinephrine	79-93	angiotensinogen	Rattus norvegicus	62-65
217278-7	1979	Also, under conditions of increased N-terminal degradation of AII, blockade of norepinephrine reuptake would be increased while the release of norepinephrine by nerve stimulation would be reduced.	Norepinephrine	143-157	angiotensinogen	Rattus norvegicus	62-65
399456-6	1979	Young white hypertensive patients (&lt; 45 years) had higher plasma noradrenaline than controls, and in white hypertensives plasma noradrenaline was positively correlated with plasma renin.	Norepinephrine	131-144	renin	Homo sapiens	183-188
436735-1	1979	Ovine PRL at low concentrations potentiated pressor responses to norepinephrine and angiotensin in an isolated perfused rat mesenteric vascular preparation.	Norepinephrine	65-79	prolactin	Rattus norvegicus	6-9
738354-1	1978	Pimozide inhibits acetylcholine and histamine-induced contractions of the isolated guinea-pig ileum and noradrenaline-induced contractions of the isolated rat vas deferens in a non-competitive manner.	Norepinephrine	104-117	arginine vasopressin	Rattus norvegicus	159-162
747468-0	1978	Regional differences in the effects of denervation, cocaine and chronic reserpine administration on the responses of the rat vas deferens to norepinephrine and acetylcholine.	Norepinephrine	141-155	arginine vasopressin	Rattus norvegicus	125-128
747468-1	1978	The prostatic half and epididymal half of the rat vas deferens was found to show the difference with respect to both the sensitivity (expressed as the geometric mean ED50) and maximal response to norepinephrine and acetylcholine.	Norepinephrine	196-210	arginine vasopressin	Rattus norvegicus	50-53
215376-0	1978	Plasma noradrenaline and adrenaline and beta-adrenoreceptor responsiveness in renin subgroups of essential hypertension.	Norepinephrine	7-20	renin	Homo sapiens	78-83
282093-13	1978	In white hypertensives plasma noradrenaline and renin activity were significantly correlated.	Norepinephrine	30-43	renin	Homo sapiens	48-53
282106-4	1978	The metabolic clearance rate of plasma noradrenaline in normal subjects was approximately 1 1 min-1 m-2, whereas in essential hypertensive patients it was significantly reduced to approximately 0.6 1 min-1 m-2.	Norepinephrine	39-52	CD59 molecule (CD59 blood group)	Homo sapiens	94-99
282106-4	1978	The metabolic clearance rate of plasma noradrenaline in normal subjects was approximately 1 1 min-1 m-2, whereas in essential hypertensive patients it was significantly reduced to approximately 0.6 1 min-1 m-2.	Norepinephrine	39-52	CD59 molecule (CD59 blood group)	Homo sapiens	200-205
282107-0	1978	Relationship of basal plasma noradrenaline to blood pressure, age, sex, plasma renin activity and plasma volume in essential hypertension.	Norepinephrine	29-42	renin	Homo sapiens	79-84
282107-7	1978	Basal plasma noradrenaline concentration was significantly higher in high renin essential hypertensive subjects compared with those with normal or low plasma renin activity.	Norepinephrine	13-26	renin	Homo sapiens	74-79
282107-9	1978	Plasma noradrenaline was reduced significantly in relatively young patients with low renin essential hypertension, but appeared to be normal in other low renin subjects.	Norepinephrine	7-20	renin	Homo sapiens	85-90
282107-11	1978	Basal plasma noradrenaline correlated significantly with blood pressure in patients with normal or low renin essential hypertension but the relationships were only significant in male patients.	Norepinephrine	13-26	renin	Homo sapiens	103-108
720776-1	1978	Norepinephrine was infused for 60 minutes in high physiological concentration (0.08 microgram/kg/min) into seven insulin dependent diabetic subjects with no demonstrable endogenous insulin secretion and into seven normal subjects.	Norepinephrine	0-14	insulin	Homo sapiens	113-120
555128-1	1979	Dopamine, noradrenaline, tyramine, amantadine and apomorphine produced concentration-related contractions of the rat vas deferens "in vitro".	Norepinephrine	10-23	arginine vasopressin	Rattus norvegicus	117-120
720776-3	1978	In the normal subjects, norepinephrine induced an initial inhibition of insulin secretion which lasted for approximately 20 minutes.	Norepinephrine	24-38	insulin	Homo sapiens	72-79
720776-7	1978	The cause of the differential metabolic response to norepinephrine between the normal and diabetic groups was not resolved, but may be related, at least in part, to suppression of endogenous insulin secretion in the normal subjects.	Norepinephrine	52-66	insulin	Homo sapiens	191-198
215466-3	1978	This suggests different mechanisms of ACTH and adrenaline effects upon UEF: the stimulating effect of noradrenaline is realized through thrombinogenesis followed by activation of the ACS function and by an increase of UEF and therefore inhibitable by hirudin which form an inactive complex with thrombin.	Norepinephrine	102-115	proopiomelanocortin	Homo sapiens	38-42
215466-3	1978	This suggests different mechanisms of ACTH and adrenaline effects upon UEF: the stimulating effect of noradrenaline is realized through thrombinogenesis followed by activation of the ACS function and by an increase of UEF and therefore inhibitable by hirudin which form an inactive complex with thrombin.	Norepinephrine	102-115	coagulation factor II, thrombin	Homo sapiens	136-144
400718-4	1978	Moreover, we have tested the effects of iv epinephrine and norepinephrine on plasma hPP concentrations.	Norepinephrine	59-73	familial progressive hyperpigmentation 1	Homo sapiens	84-87
105820-1	1978	On isolated Rat vas deferens the contracting responses of noradrenaline and dopamine are increased by mescaline (23 micromoles) and decreased by lysergide (15 micromoles).	Norepinephrine	58-71	arginine vasopressin	Rattus norvegicus	16-19
690418-4	1978	Significantly greater levels of plasma norepinephrine were present in patients with high plasma renin activity and lesser levels in patients with low renin activity than in normal renin or labile hypertensives.	Norepinephrine	39-53	renin	Homo sapiens	96-101
690418-4	1978	Significantly greater levels of plasma norepinephrine were present in patients with high plasma renin activity and lesser levels in patients with low renin activity than in normal renin or labile hypertensives.	Norepinephrine	39-53	renin	Homo sapiens	150-155
690418-4	1978	Significantly greater levels of plasma norepinephrine were present in patients with high plasma renin activity and lesser levels in patients with low renin activity than in normal renin or labile hypertensives.	Norepinephrine	39-53	renin	Homo sapiens	150-155
690418-5	1978	Blood pressure correlated significantly with plasma norepinephrine in male patients with normal renin essential hypertension but not in females.	Norepinephrine	52-66	renin	Homo sapiens	96-101
400718-10	1978	During norepinephrine infusion (6 micrograms/min for 60 min), only a minor and transient increase of plasma hPP was found.	Norepinephrine	7-21	familial progressive hyperpigmentation 1	Homo sapiens	108-111
27508-1	1978	Catechol estrogens, the 2-hydroxylated metabolites of estrogens, recently shown to be formed in brain, inhibit tyrosine hydroxylase, the enzyme that catalyzes the pivotal step in the biosynthesis of the neurotransmitters dopamine and norepinephrine.	Norepinephrine	234-248	tyrosine hydroxylase	Homo sapiens	111-131
680262-1	1978	The 30-day dynamics of noradrenaline contents after a single administration of guanitidine (50 mg/kg) was similar in the heart and small intestine but different in the vas deferens.	Norepinephrine	23-36	arginine vasopressin	Rattus norvegicus	168-171
41869-3	1978	Acetylcholine and histamine stimulated the release of AVP at the hypothalamic and pituitary levels; dopamine and norepinephrine released AVP in a dose related manner only from the hypothalamus; angiotensin II released AVP in the same fashion only from the pituitary gland.	Norepinephrine	113-127	arginine vasopressin	Rattus norvegicus	137-140
41869-3	1978	Acetylcholine and histamine stimulated the release of AVP at the hypothalamic and pituitary levels; dopamine and norepinephrine released AVP in a dose related manner only from the hypothalamus; angiotensin II released AVP in the same fashion only from the pituitary gland.	Norepinephrine	113-127	arginine vasopressin	Rattus norvegicus	137-140
41869-4	1978	AVP secretion stimulated by dopamine and norepinephrine may represent synaptic inputs which are localized at the hypothalamus and must be distinguished from the site of action at the pituitary gland of angiotensin II.	Norepinephrine	41-55	arginine vasopressin	Rattus norvegicus	0-3
731871-2	1978	The urinary excretion of noradrenaline was increased in patients with elevated peripheral plasma renin activity and in those with elevated renal vein renin ratio in comparison with the patients with normal plasma renin activity.	Norepinephrine	25-38	renin	Homo sapiens	97-102
731871-2	1978	The urinary excretion of noradrenaline was increased in patients with elevated peripheral plasma renin activity and in those with elevated renal vein renin ratio in comparison with the patients with normal plasma renin activity.	Norepinephrine	25-38	renin	Homo sapiens	150-155
731871-2	1978	The urinary excretion of noradrenaline was increased in patients with elevated peripheral plasma renin activity and in those with elevated renal vein renin ratio in comparison with the patients with normal plasma renin activity.	Norepinephrine	25-38	renin	Homo sapiens	150-155
680262-2	1978	The decrease of the noradrenaline content in the small intestine and vas deferens duct was followed by an increase of their adrenosensitivity, and the restoration of noradrenaline level--by a decrease of the adrenosensitivity, which reveals an invert relationship between these parameters (the correlation coefficient for small intestine being 0.78 and for vas deferens duct--0.61).	Norepinephrine	20-33	arginine vasopressin	Rattus norvegicus	69-72
680262-2	1978	The decrease of the noradrenaline content in the small intestine and vas deferens duct was followed by an increase of their adrenosensitivity, and the restoration of noradrenaline level--by a decrease of the adrenosensitivity, which reveals an invert relationship between these parameters (the correlation coefficient for small intestine being 0.78 and for vas deferens duct--0.61).	Norepinephrine	20-33	arginine vasopressin	Rattus norvegicus	357-360
658265-2	1978	Neither manipulation has any effect on norepinephrine-induced N-acetyl transferase (NAT) activity in vitro.	Norepinephrine	39-53	N-acetyltransferase 1	Rattus norvegicus	62-82
658265-2	1978	Neither manipulation has any effect on norepinephrine-induced N-acetyl transferase (NAT) activity in vitro.	Norepinephrine	39-53	N-acetyltransferase 1	Rattus norvegicus	84-87
697405-0	1978	[The study of the influence of vasopressin on the noradrenaline content of various cerebral areas in the rat].	Norepinephrine	50-63	arginine vasopressin	Rattus norvegicus	31-42
638883-6	1978	Results confirm that dopamine and norepinephrine directly inhibit prolactin release from pituitary and suggest that the hypothalamic mechanism inhibiting prolactin involves dopamine but not norepinephrine.	Norepinephrine	34-48	prolactin	Homo sapiens	66-75
638883-2	1978	Both dopamine and norepinephrine caused long lasting inhibition of prolactin release from either an isolated hemipituitary or a hemipituitary coincubated with a hypothalamus.	Norepinephrine	18-32	prolactin	Homo sapiens	67-76
744021-2	1978	By using the isolated rat mesenteric artery preparation, the pressor effects of norepinephrine, angiotensin II, and potassium chloride were all significantly increased when vasopressin was added to the perfusion buffer.	Norepinephrine	80-94	arginine vasopressin	Rattus norvegicus	173-184
23967-4	1978	In addition, an increased responsiveness of isolated arterial strips to norepinephrine as well as other agonists appears to contribute to the adrenergic potentiating effect of angiotensin II as well as angiotensin III.	Norepinephrine	72-86	angiotensinogen	Homo sapiens	176-190
744021-4	1978	When the vascular effects of norepinephrine were first blocked with indomethacin and then restored by the addition of prostaglandin E2, the potentiation by vasopressin was almost completely prevented.	Norepinephrine	29-43	arginine vasopressin	Homo sapiens	156-167
633087-6	1978	The antagonism of the bradykinin protein efflux by both norepinephrine and isoproterenol can be prevented by prior treatment with propranolol.	Norepinephrine	56-70	kininogen 1	Canis lupus familiaris	22-32
653304-0	1978	Renin stimulation by passive tilting: the influence of an anti-gravity suit on postural changes in plasma renin activity, plasma noradrenaline concentration and kidney function in normal man.	Norepinephrine	129-142	renin	Homo sapiens	0-5
666671-1	1978	In acute experiments on the in utero foetal lamb, angiotensin II was a more potent pressor agent that either noradrenaline or adrenaline, and the response to angiotensin II was not consistently modified by the combined administration of alpha and beta-adrenergic blocking agents.	Norepinephrine	109-122	angiotensinogen	Homo sapiens	50-64
666671-6	1978	It is concluded that the foetus, like the adult  animal, is more sensitive to angiotensin II than to catecholamines and that the biological activities of noradrenaline, angiotensin II, adrenaline and isoprenaline are reduced by perfusion through the foetal placenta.	Norepinephrine	154-167	angiotensinogen	Homo sapiens	78-92
749535-0	1978	[Effects of vasopressin and oxytocin on cerebral noradrenaline and dopamine contents and on plasma corticosterone levels].	Norepinephrine	49-62	arginine vasopressin	Homo sapiens	12-23
696418-0	1978	Renin release in relation to plasma noradrenaline during supine exercise in cardiac patients.	Norepinephrine	36-49	renin	Homo sapiens	0-5
33792-8	1978	These results indicate that several neurotransmitters, i.e., norepinephrine, serotonin, acetylcholine, and gamma-aminobutyric acid, found in high concentration in the hypothalamus, influence GH and PRL secretion.	Norepinephrine	61-75	prolactin	Rattus norvegicus	198-201
580191-2	1978	The inhibition of acetylcholinesterase by low concentration of epinephrine or norepinephrine was found to follow first-order reaction kinetics.	Norepinephrine	78-92	acetylcholinesterase (Cartwright blood group)	Homo sapiens	18-38
624999-4	1978	Noradrenaline elicited a marked increase in renin secretion in the absence of any discernible alterations in renal arterial pressure, and prolonged perfusion with Ca-free Locke solution failed to depress noradrenaline-evoked renin secretion.	Norepinephrine	0-13	renin	Homo sapiens	44-49
624999-0	1978	Stimulation of renin secretion and calcium efflux from the isolated perfused cat kidney by noradrenaline after prolonged calcium deprivation.	Norepinephrine	91-104	renin	Homo sapiens	15-20
624999-7	1978	Increasing the noradrenaline concentration produced graded increases in 45Ca efflux and renin release, and the peak rise in efflux preceded or coincided with peak renin secretion.	Norepinephrine	15-28	renin	Homo sapiens	88-93
624999-2	1978	The effects of noradrenaline on the secretion of renin and on the efflux of Ca have been investigated in the isolated cat kidney perfused with Locke solution containing the alpha-adrenergic blocking agent, phenoxybenzamine, to block increases in renal vascular resistance.	Norepinephrine	15-28	renin	Homo sapiens	49-54
624999-7	1978	Increasing the noradrenaline concentration produced graded increases in 45Ca efflux and renin release, and the peak rise in efflux preceded or coincided with peak renin secretion.	Norepinephrine	15-28	renin	Homo sapiens	163-168
624999-9	1978	DL-Propranolol inhibited the increase in 45Ca efflux and renin release resulting from noradrenaline stimulation.	Norepinephrine	86-99	renin	Homo sapiens	57-62
754399-4	1978	High renin patients had significantly elevated levels of basal plasma norepinephrine.	Norepinephrine	70-84	renin	Homo sapiens	5-10
754399-5	1978	In addition, a sub-group of the low renin population who were relatively young had reduced plasma norepinephrine conentration.	Norepinephrine	98-112	renin	Homo sapiens	36-41
754399-8	1978	Plasma norepinephrine correlated significantly with blood pressure in normal and low renin hypertensives, but the relationships were confined only to male subjects.	Norepinephrine	7-21	renin	Homo sapiens	85-90
590336-3	1977	On the other hand, pancuronium bromide (10(-6) to 10(-4) M) produced 1.62- to 2.65-fold increases in the sensitivity of the vas deferens to noradrenaline.	Norepinephrine	140-153	arginine vasopressin	Rattus norvegicus	124-127
930924-9	1977	(4) A protein binding derivative of norepinephrine or epinephrine was identified as transferrin.	Norepinephrine	36-50	transferrin	Homo sapiens	84-95
411328-0	1977	Inhibition of prolactin  secretion and synthesis by dopamine, noradrenaline and pilocarpine in cultured rat pituitary tumour cells.	Norepinephrine	62-75	prolactin	Rattus norvegicus	14-23
588376-3	1977	In patients with high plasma renin activity the excretion of noradrenaline and adrenaline was relatively high while that of dopamine was low.	Norepinephrine	61-74	renin	Homo sapiens	29-34
304104-6	1977	Noradrenaline and glycine decreased the spontaneous release of CRH from the hypothalamus but neither of these substances affected hypothalamic CRH content.	Norepinephrine	0-13	corticotropin releasing hormone	Rattus norvegicus	63-66
304104-10	1977	Noradrenaline, GABA and corticosterone reduced the acetylcholine- and 5-HT-induced increases in the release of CRH from the hypothalamus.	Norepinephrine	0-13	corticotropin releasing hormone	Rattus norvegicus	111-114
304104-11	1977	The rises in CRH content induced by acetylcholine and 5-HT were also reduced by noradrenaline and GABA but increased by corticosterone.	Norepinephrine	80-93	corticotropin releasing hormone	Rattus norvegicus	13-16
411328-2	1977	Short time treatment (0.5-2 hrs) of cell cultures with noradrenaline (10(-3) M) and dopamine (10(-3 M) reduced the spontaneous secretion of prolactin by 50% and 30%, respectively, while pilocarpine (10(-3) M) had no effect.	Norepinephrine	55-68	prolactin	Rattus norvegicus	140-149
411328-3	1977	Long-term treatment (20 hrs) with noradrenaline (10(-3)M) or with pilocarpine (10(-3) M) inhibited prolactin synthesis by 45% and 65% of control cultures, respectively.	Norepinephrine	34-47	prolactin	Rattus norvegicus	99-108
411328-8	1977	It is concluded that both noradrenaline and dopamine are able to inhibit prolactin section.	Norepinephrine	26-39	prolactin	Rattus norvegicus	73-82
198064-0	1977	Role of norepinephrine in the release of prolactin induced by suckling and estrogen.	Norepinephrine	8-22	prolactin	Rattus norvegicus	41-50
411328-9	1977	Prolactin synthesis could be inhibited by noradrenaline and pilocarpine.	Norepinephrine	42-55	prolactin	Rattus norvegicus	0-9
590207-2	1977	In the obese group the insulin-induced hypoglycemia during norepinephrine-infusion was significantly less than in normal subjects.	Norepinephrine	59-73	insulin	Homo sapiens	23-30
590207-3	1977	Moreover, the inhibition of norepinephrine-stimulated FFA and glycerol-release by insulin was significantly less in obesity as compared with the non-obese group.	Norepinephrine	28-42	insulin	Homo sapiens	82-89
593427-0	1977	Effect of catechol-O-methyl-transferase (COMT) inhibition on the vascular and metabolic responses to noradrenaline, isoprenaline and sympathetic nerve stimulation in canine subcutaneous adipose tissue.	Norepinephrine	101-114	catechol-O-methyltransferase	Canis lupus familiaris	41-45
913046-0	1977	Potentiation of pressor effects of noradrenaline and potassium ions in the rat mesenteric arteries by physiological concentrations of angiotensin II: effects of prostaglandin E2 and cortisol.	Norepinephrine	35-48	angiotensinogen	Rattus norvegicus	134-148
913046-4	1977	Angiotensin II in subpressor concentrations potentiated the vasoconstrictor response to noradrenaline and potassium chloride.	Norepinephrine	88-101	angiotensinogen	Rattus norvegicus	0-14
19605017-5	1977	Following vasopressin, the turnover of norepinephrine (NE) increased in the hypothalamus, as did these of DA in the septum and striatum.	Norepinephrine	39-53	arginine vasopressin	Rattus norvegicus	10-21
865132-4	1977	When high-renin hypertensive patients with increased levels of norepinephrine were compared with those having high renin and normal levels of norepinephrine, they showed a lesser decrease in mean arterial pressure--5 +/- 5% versus 14 +/- 4%, P less than 0.05--a decrease in plasma renin activity of 20 +/- 17% versus an increase of 77 +/- 24% (P less than 0.01), and a decrease in norepinephrine levels of 42 +/- 7% versus an increase of 10 +/- 23% (P less than 0.05) (means +/- SE).	Norepinephrine	63-77	renin	Homo sapiens	10-15
902686-0	1977	Time-response curves for barium and noradrenaline in vas deferens of castrated rat.	Norepinephrine	36-49	arginine vasopressin	Rattus norvegicus	53-56
902686-1	1977	Time-response curves for barium chloride and noradrenaline were obtained in the isolated vas deferens of 30-day castrated rats.	Norepinephrine	45-58	arginine vasopressin	Rattus norvegicus	89-92
559576-1	1977	Three days" withdrawal from long-term barbital administration results in a shift to the left and increase in the maximum response of the concentration--effect curve to norepinephrine in the isolated rat vas deferens.	Norepinephrine	168-182	arginine vasopressin	Rattus norvegicus	203-206
602198-0	1977	A comparison of the effect of cocaine desipramine on the contractions of the isolated vas deferens of the rat induced by dopamine and noradrenaline [proceedings].	Norepinephrine	134-147	arginine vasopressin	Rattus norvegicus	86-89
887505-2	1977	Bradykinin potentiated the action of nialamide with L-dopa, dopamine, 1,3-dimethyl-5-aminoadamantane, apomorphine and noradrenaline.	Norepinephrine	118-131	kininogen 1	Homo sapiens	0-10
19556183-4	1977	Three hours after the administration of vasopressin or saline the noradrenaline content of the hypothalamus, thalamus and medulla oblongata of the vasopressin-treated rats was significantly lower than that of the same parts of saline-treated rats.	Norepinephrine	66-79	arginine vasopressin	Rattus norvegicus	40-51
19556183-4	1977	Three hours after the administration of vasopressin or saline the noradrenaline content of the hypothalamus, thalamus and medulla oblongata of the vasopressin-treated rats was significantly lower than that of the same parts of saline-treated rats.	Norepinephrine	66-79	arginine vasopressin	Rattus norvegicus	147-158
19556183-5	1977	These results indicate that vasopressin increases nerve impulse flow in noradrenaline neurons in particular brain regions.	Norepinephrine	72-85	arginine vasopressin	Rattus norvegicus	28-39
887505-3	1977	Spiroperidol abolished potentializing effect of bradykinin on the central action of nialamide with L-DOPA and of noradrenaline.	Norepinephrine	113-126	kininogen 1	Homo sapiens	48-58
887505-4	1977	In animals receiving spiroperidol with bradykinin psychostimulatory action of noradrenaline was also not observed.	Norepinephrine	78-91	kininogen 1	Homo sapiens	39-49
334645-4	1977	Acetylcholine, norepinephrine, histamine, angiotensin II, gamma-aminobutyric acid and L-glutamic acid have been regarded as candidates of chemical transmitters for the release of ADH in the hypothalamus.	Norepinephrine	15-29	arginine vasopressin	Homo sapiens	179-182
901019-0	1977	[Parameters of interaction between noradrenaline and serum albumin].	Norepinephrine	35-48	albumin	Homo sapiens	59-66
334645-8	1977	It appears that norepinephrine, histamine, angiotensin II, PGE2 and bradykinin stimulate directly the neural lobe to release ADH.	Norepinephrine	16-30	arginine vasopressin	Homo sapiens	125-128
826297-3	1976	It is estimated that the equi-potent molar ratio for TRH: noradrenaline:calcium is 1:900:27,000.	Norepinephrine	58-71	thyrotropin releasing hormone	Felis catus	53-56
190256-8	1977	The adenylate cyclase of two ectopic ACTH producing tumors (gastric carcinoid and malignant thymoma) was activated by TRH, LH-RH, norepinephrine, epinephrine, serotonin, PGE1 and MEE.	Norepinephrine	130-144	proopiomelanocortin	Homo sapiens	37-41
834247-0	1977	Suppression of noradrenaline synthesis in sympathetic nerves by carbidopa, an inhibitor of peripheral dopa decarboxylase.	Norepinephrine	15-28	dopa decarboxylase	Homo sapiens	102-120
615448-4	1977	Vasopressin also completely blocked an increase induced in the plasma non-esterified fatty acid level by activating hormone-sensitive lipase in the adipose tissue by the infusion of 0.5 mg noradrenaline.	Norepinephrine	189-202	arginine vasopressin	Homo sapiens	0-11
1071602-2	1976	Patients with mild essential hypertension and elevated plasma renin activity, when compared with normal subjects and hypertensive subjects with normal plasma renin, demonstrated features of sympathetic nervous cardiovascular excitation, accompanied by a raised plasma noradrenaline concentration.	Norepinephrine	268-281	renin	Homo sapiens	62-67
1071652-0	1976	Effect of angiotensin II on noradrenaline content in the rat hypothalamus.	Norepinephrine	28-41	angiotensinogen	Rattus norvegicus	10-24
11370247-8	1976	It is suggested that the dopamine beta-hydroxylase activity in cerebrospinal fluid may be derived from noradrenergic neurons within the brain and that the enzyme is released together with noradrenaline.	Norepinephrine	188-201	dopamine beta-hydroxylase	Oryctolagus cuniculus	25-50
1012341-3	1976	In vas deferens from non-reserpinized rats the release of noradrenaline evoked by veratridine was partially antagonized by omission of Ca2+ in the incubation medium and partially inhibited by low concentrations of desipramine.	Norepinephrine	58-71	arginine vasopressin	Rattus norvegicus	3-6
1012987-2	1976	A treatment with bradykinin and the low dose of amphetamine reduced the noradrenaline and enhanced the serotonin level in the striatum, and lowered the dopamine content in the cortex, while a combined treatment with the high dose of amphetamine elevated the dopamine level in the striatum and hypothalamus and depressed the serotonin level in the midbrain.	Norepinephrine	72-85	kininogen 1	Homo sapiens	17-27
1012341-4	1976	In reserpinized vas deferens the release of noradrenaline like that of bretylium in normal vas was not affected by omission of Ca2+ but inhibited by low concentrations (3-5 X 10(-7) M) of desipramine.	Norepinephrine	44-57	arginine vasopressin	Rattus norvegicus	16-19
1012341-4	1976	In reserpinized vas deferens the release of noradrenaline like that of bretylium in normal vas was not affected by omission of Ca2+ but inhibited by low concentrations (3-5 X 10(-7) M) of desipramine.	Norepinephrine	44-57	arginine vasopressin	Rattus norvegicus	91-94
1012341-7	1976	It is concluded that noradrenaline is released by veratridine from normal vas deferens by two mechanisms: 1) an exocytosis release, 2) a carrier mediated desipramine sensitive outward transport; In reserpinized tissue the second mechanism is solely responsible for the release of noradrenaline.	Norepinephrine	21-34	arginine vasopressin	Rattus norvegicus	74-77
182325-2	1976	After addition of norepinephrine, dopamine or adenosine to the perfusates the output of cyclic AMP was enhanced, whilst serotonin and histamine were found to be ineffective.	Norepinephrine	18-32	transmembrane serine protease 5	Rattus norvegicus	95-98
12529-2	1976	It was shown that bradykinin in a dose of 4 mug decreased the content of norepinephrine in corpus striatum, midbrain, and cerebellum.	Norepinephrine	73-87	kininogen 1	Homo sapiens	18-28
12529-7	1976	It was also shown that bradykinin increased norepinephrine uptake by the blood platelets when its level in the platelets was low, and released the absorbed norepinephrine into the medium when the level of norepinephrine was higher.	Norepinephrine	44-58	kininogen 1	Homo sapiens	23-33
12529-7	1976	It was also shown that bradykinin increased norepinephrine uptake by the blood platelets when its level in the platelets was low, and released the absorbed norepinephrine into the medium when the level of norepinephrine was higher.	Norepinephrine	156-170	kininogen 1	Homo sapiens	23-33
12529-7	1976	It was also shown that bradykinin increased norepinephrine uptake by the blood platelets when its level in the platelets was low, and released the absorbed norepinephrine into the medium when the level of norepinephrine was higher.	Norepinephrine	156-170	kininogen 1	Homo sapiens	23-33
182325-3	1976	The effects of noradrenaline and dopamine on cyclic AMP were found to be mediated by different receptors: haloperidol antagonized only the dopamine response.	Norepinephrine	15-28	transmembrane serine protease 5	Rattus norvegicus	52-55
988183-13	1976	In similar doses, both dopamine and noradrenaline injected into the lateral cerebral ventricles of the brain of the anaesthetized, hydrated, lactating rat caused the release of arginine vasopressin and oxytocin.	Norepinephrine	36-49	arginine vasopressin	Rattus norvegicus	186-197
974400-0	1976	Effect of denervation and cocaine on the response of isolated rat vas deferens to noradrenaline and methoxamine [proceedings].	Norepinephrine	82-95	arginine vasopressin	Rattus norvegicus	66-69
974350-0	1976	Desensitization of the rat aortic strip to vasopressin by infusions of noradrenaline [proceedings].	Norepinephrine	71-84	arginine vasopressin	Rattus norvegicus	43-54
1021647-0	1976	The irreversible inhibitory effects of dibenamine on the noradrenaline-, K- and Ba-induced contractions of rat"s isolated vas deferens, particularly in relation to Ca.	Norepinephrine	57-70	arginine vasopressin	Rattus norvegicus	122-125
1021648-0	1976	The irreversible inhibitory effects of phenoxybenzamine on the noradrenaline-, K- and Ba-induced contractions of rat"s isolated vas deferens, particularly in relation to Ca.	Norepinephrine	63-76	arginine vasopressin	Rattus norvegicus	128-131
825886-4	1976	These significant changes after alpha-MSH were of a much smaller magnitude than were observed after prostaglandins E1 and E2, isoproterenol, bradykinin or glyceryl trinitrate and differed completely from the increased resistance after angiotensin II and norepinephrine.	Norepinephrine	254-268	proopiomelanocortin	Homo sapiens	32-41
962435-0	1976	Vas deferens desensitization by noradrenaline and other drugs.	Norepinephrine	32-45	arginine vasopressin	Rattus norvegicus	0-3
947939-0	1976	Effect of norepinephrine infusion on plasma vasopressin levels in normal human subjects.	Norepinephrine	10-24	arginine vasopressin	Homo sapiens	44-55
947939-4	1976	These results suggest that norepinephrine-induced water diuresis is related to the suppression of the vasopressin release.	Norepinephrine	27-41	arginine vasopressin	Homo sapiens	102-113
962435-1	1976	Desensitization of the isolated rat vas deferens was demonstrated by using noradrenaline, 5-hydroxytryptamine, carbachol, acetylcholine or barium chloride as a test concentration after a large concentration (concentration producing a contraction that was 80% of the maximum) of the same agonist.	Norepinephrine	75-88	arginine vasopressin	Rattus norvegicus	36-39
181100-3	1976	Reduction of the cAMP level was probably connected with noradrenaline and other biologically-active amine deficiency in the brain under conditions of extreme stimulation.	Norepinephrine	56-69	cathelicidin antimicrobial peptide	Rattus norvegicus	17-21
932982-0	1976	Conformationally defined adrenergic agents I: potentiation of levarterenol in rat vas deferens by endo- and exo- 2- aminobenzobicyclo[2.2.2]octenes, conformationally defined analogs of amphetamine.	Norepinephrine	62-74	arginine vasopressin	Rattus norvegicus	82-85
932982-1	1976	Four conformationally defined analogs of amphetamine were synthesized and studied for their ability to potentiate the action of levarterenol on the isolated vas deferens from reserpine-treated rats.	Norepinephrine	128-140	arginine vasopressin	Rattus norvegicus	157-160
1262901-5	1976	The first plasma noradrenaline peak may be important in inhibiting further insulin secretion.	Norepinephrine	17-30	insulin	Homo sapiens	75-82
179579-2	1976	This enzymatic activity is strongly stimulated by NaF and 5"-guanylimidodiphosphate, is slightly stimulated by epinephrine, norepinephrine, isoproterenol, and prostaglandin E1 and is inhibited by calcium.	Norepinephrine	124-138	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
5568-7	1976	Noradrenaline blocked the release of CRH induced by both acetylcholine and 5-hydroxytryptamine and presumably this inhibition was caused by direct action on the CRH neurone.	Norepinephrine	0-13	corticotropin releasing hormone	Rattus norvegicus	37-40
5568-7	1976	Noradrenaline blocked the release of CRH induced by both acetylcholine and 5-hydroxytryptamine and presumably this inhibition was caused by direct action on the CRH neurone.	Norepinephrine	0-13	corticotropin releasing hormone	Rattus norvegicus	161-164
938990-1	1976	Exogenous angiotensin II causes noradrenaline supersensitivity in rat mesenteric vasculature preparations.	Norepinephrine	32-45	angiotensinogen	Rattus norvegicus	10-24
185101-13	1976	Using this method, it found that LVP, AVP, norepinephrine (100 ng/ml200 ng/ml) and 5-hydroxytryptophane (1 mug/ml) had ACTH releasing activities but LH-RH, TRH, glucagon, dopamine, phentolamine, propranolol, haloperidol, prostaglandin E1 and indomethacin did not affect the release of ACTH.	Norepinephrine	43-57	proopiomelanocortin	Homo sapiens	119-123
185101-13	1976	Using this method, it found that LVP, AVP, norepinephrine (100 ng/ml200 ng/ml) and 5-hydroxytryptophane (1 mug/ml) had ACTH releasing activities but LH-RH, TRH, glucagon, dopamine, phentolamine, propranolol, haloperidol, prostaglandin E1 and indomethacin did not affect the release of ACTH.	Norepinephrine	43-57	proopiomelanocortin	Homo sapiens	285-289
1248509-0	1976	The effects of cocaine and diphenhydramine upon the reactivity of rat vas deferens to supramaximal doses of noradrenaline and of other agonists: the mode of action of cocaine.	Norepinephrine	108-121	arginine vasopressin	Rattus norvegicus	70-73
1248509-4	1976	It is proposed that the prejunctional action of cocaine and of diphenhydramine to reduce the rate of neuronal uptake of noradrenaline may provide a sufficient explanation for the enhanced reactivity of the vas deferens to noradrenaline, as this would allow an increased rate of rise of amine concentration at the receptors.	Norepinephrine	120-133	arginine vasopressin	Rattus norvegicus	206-209
1248509-4	1976	It is proposed that the prejunctional action of cocaine and of diphenhydramine to reduce the rate of neuronal uptake of noradrenaline may provide a sufficient explanation for the enhanced reactivity of the vas deferens to noradrenaline, as this would allow an increased rate of rise of amine concentration at the receptors.	Norepinephrine	222-235	arginine vasopressin	Rattus norvegicus	206-209
1001624-0	1976	The effects of noradrenaline and adrenaline on the phospholipase A2-acylation system of preparations of plasma membrane of heart.	Norepinephrine	15-28	phospholipase A2 group IB	Homo sapiens	51-67
6671-4	1976	Phosvitin alone was found to prevent the hypoxia-induced T-wave changes (flattening or disappearance), which were also temporarily aggravated by injection of noradrenaline.	Norepinephrine	158-171	casein kinase 2 beta	Rattus norvegicus	0-9
1052611-0	1976	Immunization against angiotensin II and its relationship with the norepinephrine content of the hypothalamus and medulla oblongata.	Norepinephrine	66-80	angiotensinogen	Homo sapiens	21-35
999466-3	1976	The influence of bradykinin and kallikrein on the action of norepinephrine, epinephrine, isoprenaline, phentolamine, propranolol, aminophylline and theophylline on blood pressure was studied.	Norepinephrine	60-74	kininogen 1	Homo sapiens	17-27
765118-8	1976	Infusion of norepinephrine or epinephrine partially suppressed the prolactin rise but only after 2 h of infusion.	Norepinephrine	12-26	prolactin	Rattus norvegicus	67-76
172259-3	1976	The potentiation of vasoconstrictor responses to sympathetic nerve stimulation and injected norepinephrine which was elicited by renin substrate and angiotensin I was abolished by an inhibitor of angiotensin I-converting enzyme, SQ 20,881, and by an angiotensin II receptor antagonist, [Sar1-Ile8]angiotensin II.	Norepinephrine	92-106	angiotensinogen	Rattus norvegicus	250-264
172259-3	1976	The potentiation of vasoconstrictor responses to sympathetic nerve stimulation and injected norepinephrine which was elicited by renin substrate and angiotensin I was abolished by an inhibitor of angiotensin I-converting enzyme, SQ 20,881, and by an angiotensin II receptor antagonist, [Sar1-Ile8]angiotensin II.	Norepinephrine	92-106	angiotensinogen	Rattus norvegicus	297-311
6242-6	1976	Data are presented which suggest the existence of a presynaptic beta1-receptor mediating a positive feedback mechanism on neuronal release of noradrenaline.	Norepinephrine	142-155	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	64-69
6246-3	1976	High concentrations of beta-adrenoreceptor antagonists (threshold about 30 muM) also release noradrenaline from intraneuronal stores; however, their intrinsic sympathomimetic activity is generally attributed to their partial agonist property.	Norepinephrine	93-106	latexin	Homo sapiens	75-78
1249752-2	1976	The contractile responses of rat vas deferens to noradrenaline and K+ are composed of phasic and tonic components both of which are dependent upon the concentration of extracellular Ca2+.	Norepinephrine	49-62	arginine vasopressin	Rattus norvegicus	33-36
1534-6	1976	On the reserpinized rat vas deferens all compounds potentiated the effects of exogenous norepinephrine.	Norepinephrine	88-102	arginine vasopressin	Rattus norvegicus	24-27
5576-3	1976	After inhibition of monoamine synthesis by N"-(DL-SERYL)-N2-(2, 3, 4-trihydroxybenzyl)hydrazine, substance P significantly accelerated the disappearance of dopamine, noradrenaline and 5-hydroxytryptamine.	Norepinephrine	166-179	tachykinin precursor 1	Homo sapiens	97-108
986352-4	1976	Sensitivity of the denervated vas deferens for noradrenaline was strongly reduced by phospholipase C treatment.	Norepinephrine	47-60	arginine vasopressin	Rattus norvegicus	30-33
986352-5	1976	These data suggest that the supersensitivity of the denervated vas deferens for noradrenaline was mainly due to the increase in phospholipids.	Norepinephrine	80-93	arginine vasopressin	Rattus norvegicus	63-66
1196132-3	1975	The insulin inhibition of noradrenaline-stimulated lipolysis was blunted.	Norepinephrine	26-39	insulin	Homo sapiens	4-11
171381-5	1975	Indomethacin, 14-0 muM, prevented the release of PGE-like material in the venous effluent of the spleen elicited by either nerve stimulation or by exogenous noradrenaline.	Norepinephrine	157-170	latexin	Homo sapiens	19-22
1160969-4	1975	Since dihydropteridine reductase is also essential for the biosynthesis of dopamine, norepinephrine, and serotonin, disturbed neurotransmitter function may be responsible for the patient"s neurologic deterioration.	Norepinephrine	85-99	quinoid dihydropteridine reductase	Homo sapiens	6-32
1183487-0	1975	The effect of pretreatment with 6-hydroxydopamine on the norepinephrine concentration and sensitivity of the rat vas deferens.	Norepinephrine	57-71	arginine vasopressin	Rattus norvegicus	113-116
1222215-3	1975	High norepinephrine concentration has an inhibitory effect on renin secretion which is reversed by phentolamine: activation of alpha receptors probably decreases renin release.	Norepinephrine	5-19	renin	Homo sapiens	62-67
1222215-3	1975	High norepinephrine concentration has an inhibitory effect on renin secretion which is reversed by phentolamine: activation of alpha receptors probably decreases renin release.	Norepinephrine	5-19	renin	Homo sapiens	162-167
1183487-1	1975	Injection of 6-hydroxydopamine via the dorsal vein of the penis results in a marked depletion of the endogenous norepinephrine of the vas deferens.	Norepinephrine	112-126	arginine vasopressin	Rattus norvegicus	134-137
165982-5	1975	On the one hand, insulin action (glucose transport) is inhibited by compounds (cholera toxin, ACTH, glucagon and L-norepinephrine) that stimulate adenylate cyclase; conversely, insulin both inhibits the lipolytic action of these compounds, and raises cellular levels of cyclic GMP.	Norepinephrine	113-129	insulin	Homo sapiens	17-24
1195552-4	1975	At the same time in subjects of advanced age the reactivity of the mediatory link in systolic hypertension remains intact, this manifesting itself in a significantly increased noradrenaline passage, as compared to a low initial level following administration of insulin.	Norepinephrine	176-189	insulin	Homo sapiens	262-269
2494-1	1975	By employing spectrofluorometry and quantitative fluorescent histochemistry the norepinephrine (NE) content in the tissue and in the adrenergic nerves of Vas deferens of the rat after depletion of the transmitter"s reserves with tyramine and their subsequent replenishment through incubation of the tissue with exogenous NE was measured.	Norepinephrine	80-94	arginine vasopressin	Rattus norvegicus	154-157
1152295-12	1975	Norepinephrine induced significantly greater pressor effect in normal or high renin essential hypertension.	Norepinephrine	0-14	renin	Homo sapiens	78-83
1152295-13	1975	The adopted dose of norepinephrine suppressed both PRA and PAC and a tendency to the greater fall in PRA was observed in normal or high renin essential hypertension.	Norepinephrine	20-34	renin	Homo sapiens	136-141
238023-4	1975	Marked decreases (80-98%) in the norepinephrine concentration in several tissues (heart, spleen, intestine, mesentery, kidney, uterus, vas deferens) were observed in the guanethidine-treated rats when compared to saline-treated controls.	Norepinephrine	33-47	arginine vasopressin	Rattus norvegicus	135-138
1149798-0	1975	Nature of neuronal uptake and noradrenaline--adrenaline effects in the isolated rat vas deferens.	Norepinephrine	30-43	arginine vasopressin	Rattus norvegicus	84-87
166557-1	1975	In short-term incubations of fat cells isolated from human adipose tissue, noradrenaline (0.2-2x10--5 M), a mixed alpha and beta-adrenergic agonist, stimulated only slightly cyclic AMP accumulation.	Norepinephrine	75-88	adenine phosphoribosyltransferase	Homo sapiens	181-184
1142752-0	1975	Norepinephrine-induced insulin and substrate changes in normal man: incomplete reversal by phentolamine.	Norepinephrine	0-14	insulin	Homo sapiens	23-30
1142157-4	1975	Noradrenaline-induced hypothermia was associated with reduced carbon dioxide elimination and reduced blood lactate concentrations whereas leg temperature, electromyographic activity, plasma NEFA and plasma glucose concentrations were increased.	Norepinephrine	0-13	NEFA	Gallus gallus	190-194
1168515-4	1975	2 Noradrenaline (1.18 times 10-minus 4M) and adrenaline (1.09 times 10-minus 4M) added to the incubation medium stimulated renin production by 45 and 34% respectively, compared with the incubated controls.	Norepinephrine	2-15	renin	Homo sapiens	123-128
1213521-0	1975	[Role of catechol-o-methyltransferase on the termination of noradrenaline activity in the rabbit"s isolated aortic strip].	Norepinephrine	60-73	catechol O-methyltransferase	Oryctolagus cuniculus	9-37
239647-6	1975	The results suggest that angiotensin II facilitates neuronal release of noradrenaline and that this effect is revealed most clearly when post-synaptic angiotensin II receptors are blocked.	Norepinephrine	72-85	angiotensinogen	Rattus norvegicus	25-39
239647-6	1975	The results suggest that angiotensin II facilitates neuronal release of noradrenaline and that this effect is revealed most clearly when post-synaptic angiotensin II receptors are blocked.	Norepinephrine	72-85	angiotensinogen	Rattus norvegicus	151-165
1079076-6	1975	Noradrenaline (10 ng), however, was able to inhibit the release of CRH in response to acetylcholine (3 pg) and this action of noradrenaline was reduced by phentolamine (100 ng), an alpha adrenergic blocking agent.	Norepinephrine	0-13	corticotropin releasing hormone	Rattus norvegicus	67-70
1079076-6	1975	Noradrenaline (10 ng), however, was able to inhibit the release of CRH in response to acetylcholine (3 pg) and this action of noradrenaline was reduced by phentolamine (100 ng), an alpha adrenergic blocking agent.	Norepinephrine	126-139	corticotropin releasing hormone	Rattus norvegicus	67-70
1165793-2	1975	Dopamine, 0.20 muM, and (-)- noradrenaline, 0.18 muM, inhibited 3H-noradrenaline release elicited by nerve stimulation at 4 or 10 Hz.	Norepinephrine	24-42	latexin	Homo sapiens	49-52
1123719-1	1975	Chronic postganglionic denervation of the rate vas deferens produces an increase in the sensitivity of the in vitro smooth muscle to norepinephrine, methoxamine, acetylcholine, potassium and electrical stimulation.	Norepinephrine	133-147	arginine vasopressin	Rattus norvegicus	47-50
813283-1	1975	The effect of catecholamines, represented by epinephrine and norepinephrine, on the activity of phospholipase A2 from bee venom was studied.	Norepinephrine	61-75	phospholipase A2 group IB	Homo sapiens	96-112
1216108-0	1975	Reflex stimulation of peripheral norepinephrine release: effect of nephrectomy and a physiological rate of angiotensin-II infusion.	Norepinephrine	33-47	angiotensinogen	Homo sapiens	107-121
1165793-5	1975	Phentolamine, 1 muM, antagonized more effectively the inhibitory effects of (-)-noradrenaline than those of dopamine.	Norepinephrine	76-93	latexin	Homo sapiens	16-19
1165793-6	1975	Phenoxybenzamine, 0.29 muM, prevented the inhibition of 3H-transmitter overflow obtained with (-)-noradrenaline, dopamine or apomorphine.	Norepinephrine	94-111	latexin	Homo sapiens	23-26
4418715-0	1974	Effects of prolactin on the responses of the isolated mesenteric artery of the rat to noradrenaline.	Norepinephrine	86-99	prolactin	Rattus norvegicus	11-20
4413101-0	1974	Effect of theophylline and adrenergic blocking drugs on the renin response to norepinephrine in vitro.	Norepinephrine	78-92	renin	Homo sapiens	60-65
4847245-7	1974	There was a significant negative correlation between the initial rise in insulin expressed in percentage of the basal insulin concentration and the plasma noradrenaline level.	Norepinephrine	155-168	insulin	Homo sapiens	73-80
4376675-0	1974	The involvement of calcium and angiotensin II in vascular reactivity to noradrenaline in renal/salt hypertension.	Norepinephrine	72-85	angiotensinogen	Homo sapiens	31-45
4153328-0	1974	Effect of fluacizine on the uptake of exogenous noradrenalin by the isolated rat vas deferens.	Norepinephrine	48-60	arginine vasopressin	Rattus norvegicus	81-84
4417825-0	1974	Comparative study of cumulative and non-cumulative dose-response curves for noradrenaline and adrenaline in the isolated rat vas deferens.	Norepinephrine	76-89	arginine vasopressin	Rattus norvegicus	125-128
4847245-13	1974	It is conceivable that any effect of plasma noradrenaline on the basal insulin secretion was neutralized by the fasting hyperglycemia.	Norepinephrine	44-57	insulin	Homo sapiens	71-78
4847245-7	1974	There was a significant negative correlation between the initial rise in insulin expressed in percentage of the basal insulin concentration and the plasma noradrenaline level.	Norepinephrine	155-168	insulin	Homo sapiens	118-125
4603502-0	1974	[Effect of norepinephrine on glucose-stimulated insulin secretion in man].	Norepinephrine	11-25	insulin	Homo sapiens	48-55
4829861-0	1974	Comparison of the renin response to dopamine and noradrenaline in normal subjects and patients with autonomic insufficiency.	Norepinephrine	49-62	renin	Homo sapiens	18-23
4823462-3	1974	The effects of noradrenaline and 5-hydroxytryptamine are blocked by phentolamine and methysergide respectively.3 The cat anococcygeus is relaxed by acetylcholine, carbachol, isoprenaline, ATP, prostaglandins E(1), E(2) and F(2alpha) and vasopressin, all of which contract the rat muscle.	Norepinephrine	15-28	arginine vasopressin	Rattus norvegicus	237-248
4829169-0	1974	Proceedings: Effects of prolactin on the responses of rat aortic wall strips to noradrenaline.	Norepinephrine	80-93	prolactin	Rattus norvegicus	24-33
4857896-0	1974	The effects of prolactin on the responses of the isolated mesenteric artery of the rat to noradrenaline.	Norepinephrine	90-103	prolactin	Rattus norvegicus	15-24
4476172-0	1974	Noradrenaline stimulation of phosphatidylinositol breakdown in rat vas deferens.	Norepinephrine	0-13	arginine vasopressin	Rattus norvegicus	67-70
4127278-0	1973	Effects of prolactin on the responses of rat aortic and arteriolar smooth-muscle preparations to noradrenaline and angiotensin.	Norepinephrine	97-110	prolactin	Rattus norvegicus	11-20
4775940-0	1973	In vivo prevention by catalase of the early effect of 6-hydroxydopamine on rat heart norepinephrine.	Norepinephrine	85-99	catalase	Rattus norvegicus	22-30
4351773-0	1973	Effect of hypopituitarism and ACTH on the urinary excretion of norepinephrine in man.	Norepinephrine	63-77	proopiomelanocortin	Homo sapiens	30-34
4693186-0	1973	Long-lasting supersensitivity of the rat vas deferens to norepinephrine after chronic guanethidine administration.	Norepinephrine	57-71	arginine vasopressin	Rattus norvegicus	41-44
4691864-0	1973	Response of glucose, insulin, free fatty acid, and human growth hormone to norepinephrine and hemorrhage in normal man.	Norepinephrine	75-89	growth hormone 1	Homo sapiens	57-71
4656611-4	1972	Bradykinin-insensitive vein and aortic strips responded with substantial increases in contractile tension when exposed to prostaglandin E(2), noradrenaline, histamine and KC1.	Norepinephrine	142-155	kininogen 1	Homo sapiens	0-10
4689406-0	1973	The requirement of cortisol for the inhibitory effect of norepinephrine on the antidiuretic action of vasopressin.	Norepinephrine	57-71	arginine vasopressin	Homo sapiens	102-113
4345637-6	1973	Norepinephrine and prostaglandin E(1), which in this tissue reduce the hydrosmotic action of ADH, presumably by inhibiting the adenyl cylase also reduced the effect of hyperosmolarity.	Norepinephrine	0-14	arginine vasopressin	Homo sapiens	93-96
4341975-0	1972	In vitro effects on cardiac norepinephrine of angiotensin II and of two indirectly acting sympathomimetic amines (amphetamine and tyramine).	Norepinephrine	28-42	angiotensinogen	Homo sapiens	46-60
4117772-1	1972	The transport of norepinephrine and two key enzymes involved in its synthesis, tyrosine hydroxylase (EC 1.14.3a) and dopamine beta-hydroxylase (EC 1.14.2.1), has been studied in relation to other axonal constituents in ligated chicken sciatic nerves.	Norepinephrine	17-31	dopamine beta-hydroxylase	Gallus gallus	117-142
5075509-5	1972	However, in the presence of noradrenaline and salbutamol, insulin exerted a consistent antilipolytic effect.	Norepinephrine	28-41	insulin	Homo sapiens	58-65
5076396-10	1972	Noradrenaline (1 muM) markedly increased the efflux of (42)K and within 2 min caused tissue potassium to fall by 8%.	Norepinephrine	0-13	latexin	Homo sapiens	17-20
5076396-14	1972	Noradrenaline (1 muM) caused a reversible hyperpolarization of about 10 mV.	Norepinephrine	0-13	latexin	Homo sapiens	17-20
4506092-1	1972	Potassium concentrations above 15-20 mM in the medium, or addition of 75 muM veratridine to medium that contains 5 mM K, stimulate calcium accumulation and Ca-dependent norepinephrine release by presynaptic nerve terminals (synaptosomes) incubated in vitro.	Norepinephrine	169-183	latexin	Homo sapiens	73-76
4676430-2	1972	Effect of the insulin of other species on norepinephrine induced lipolysis].	Norepinephrine	42-56	insulin	Homo sapiens	14-21
5021294-0	1972	The effect of albumin infusion upon plasma norepinephrine concentration in nephrotic children.	Norepinephrine	43-57	albumin	Homo sapiens	14-21
5046102-2	1972	Norepinephrine release by bradykinin.	Norepinephrine	0-14	kininogen 1	Homo sapiens	26-36
4347475-0	1971	Selective release of newly synthesized cardiac norepinephrine induced by angiotensin II.	Norepinephrine	47-61	angiotensinogen	Homo sapiens	73-87
4340798-0	1972	Failure of angiotensin II to inhibit the uptake of noradrenaline by the catecholamine-depleted vas deferens of the rat.	Norepinephrine	51-64	angiotensinogen	Rattus norvegicus	11-25
5152027-6	1971	Hypoglycaemia induced by insulin increased catecholamine secretion, with the adrenaline to noradrenaline ratio significantly higher than in the adrenal gland itself.6.	Norepinephrine	91-104	insulin	Homo sapiens	25-32
4399918-0	1971	Analysis of the supersensitivity to noradrenaline induced by amphetamine in the isolated vas deferens of the rat.	Norepinephrine	36-49	arginine vasopressin	Rattus norvegicus	89-92
4108421-0	1971	Fine structure of noradrenaline storage vesicles in nerve terminals of the rat vas deferens.	Norepinephrine	18-31	arginine vasopressin	Rattus norvegicus	79-82
5102477-1	1971	Diethyldithiocarbamate, a dopamine beta hydroxylase inhibitor, decreases biosynthesis of norepinephrine in the brain.	Norepinephrine	89-103	dopamine beta hydroxylase	Mus musculus	26-51
4391635-0	1970	Effect of adrenergic blocking agents on the vasopressin inhibiting action of norepinephrine.	Norepinephrine	77-91	arginine vasopressin	Homo sapiens	44-55
5579649-2	1971	The subcellular distribution of noradrenaline in sympathetic nerve terminals of rat vas deferens and cat spleen has been studied by cell fractionation methods combined with fluorescence and electronmicroscopic histochemical methods for noradrenaline.2.	Norepinephrine	32-45	arginine vasopressin	Rattus norvegicus	84-87
4395231-4	1971	These results support the hypothesis that norepinephrine and acetylcholine are directly involved in controlling the release of antidiuretic hormone.	Norepinephrine	42-56	arginine vasopressin	Homo sapiens	127-147
4321672-0	1970	[Action, in vitro and in vivo, of angiotensin II on cardiac uptake of noradrenaline].	Norepinephrine	70-83	angiotensinogen	Homo sapiens	34-48
5463064-4	1970	Assessment of differential actions of d- and 1-amphetamine may be an efficient method to differentiate behaviors involving norepinephrine or dopamine in the brain.	Norepinephrine	123-137	NBL1, DAN family BMP antagonist	Homo sapiens	38-46
5416117-0	1970	Partial separation and properties of tyrosine hydroxylase from the human pheochromocytoma: effect of norepinephrine.	Norepinephrine	101-115	tyrosine hydroxylase	Homo sapiens	37-57
4306902-0	1969	Inhibition of norepinephrine uptake in hearts by angiotensin II and analogs.	Norepinephrine	14-28	angiotensinogen	Homo sapiens	49-63
5818077-0	1969	Influence of norepinephrine and catecholamine-depleting agents on the synthesis and release of prolactin and growth hormone.	Norepinephrine	13-27	prolactin	Homo sapiens	95-104
5818077-0	1969	Influence of norepinephrine and catecholamine-depleting agents on the synthesis and release of prolactin and growth hormone.	Norepinephrine	13-27	growth hormone 1	Homo sapiens	109-123
5352047-0	1969	Effect of perfusion with K-rich solutions on the noradrenaline content of the rat vas deferens.	Norepinephrine	49-62	arginine vasopressin	Rattus norvegicus	82-85
4304350-0	1969	In vitro stimulation of renin production by epinephrine, norepinephrine, and cyclic AMP.	Norepinephrine	57-71	renin	Homo sapiens	24-29
5809732-5	1969	The role of catechol-O-methyl transferase (COMT), but not that of monoamine oxidase (MAO), in terminating the action of noradrenaline was increased in strips from animals pretreated with reserpine.	Norepinephrine	120-133	catechol O-methyltransferase	Oryctolagus cuniculus	12-41
5809732-5	1969	The role of catechol-O-methyl transferase (COMT), but not that of monoamine oxidase (MAO), in terminating the action of noradrenaline was increased in strips from animals pretreated with reserpine.	Norepinephrine	120-133	catechol O-methyltransferase	Oryctolagus cuniculus	43-47
5660158-0	1968	A new type of drug enhancement: increased maximum response to cumulative noradrenaline in the isolated rat vas deferens.	Norepinephrine	73-86	arginine vasopressin	Rattus norvegicus	107-110
5726781-0	1968	The effects of drugs inhibiting catecholamine uptake on tyramine and noradrenaline-induced contractions of the isolated rat vas deferens.	Norepinephrine	69-82	arginine vasopressin	Rattus norvegicus	124-127
5726781-7	1968	Imipramine inhibited the in vitro uptake of noradrenaline-(3)H in rat vas deferens as did cocaine, desmethylimipramine and dexchlorpheniramine.	Norepinephrine	44-57	arginine vasopressin	Rattus norvegicus	70-73
4302130-0	1968	The mechanism of supersensitivity to norepinephrine induced by cocaine in rat isolated vas deferens.	Norepinephrine	37-51	arginine vasopressin	Rattus norvegicus	87-90
4297616-0	1968	Effects of angiotensin, norepinephrine and renal artery constriction on erythropoietin production.	Norepinephrine	24-38	erythropoietin	Homo sapiens	72-86
4316222-0	1968	Effect of dibutyryl-3",5"-AMP, theophylline and norepinephrine on lipolytic action of growth hormone and glucocorticoid in white fat cells.	Norepinephrine	48-62	growth hormone 1	Homo sapiens	86-100
5637142-0	1968	Norepinephrine inhibition of vasopressin antidiuresis.	Norepinephrine	0-14	arginine vasopressin	Homo sapiens	29-40
5659751-0	1968	Effect of reserpine on the noradrenaline content of the vas deferens and the seminal vesicle compared with the submaxillary gland and the heart of the rat.	Norepinephrine	27-40	arginine vasopressin	Rattus norvegicus	56-59
5637142-1	1968	The effect of norepinephrine on exogenous vasopressin antidiuresis was investigated in water-loaded subjects.	Norepinephrine	14-28	arginine vasopressin	Homo sapiens	42-53
5637142-8	1968	A post-phase 3 infusion of vasopressin in four subjects resulted in a marked decrease in free water clearance, indicating that the norepinephrine inhibition of vasopressin antidiuresis was not accountable on the basis of decreased medullary hypertonicity.	Norepinephrine	131-145	arginine vasopressin	Homo sapiens	27-38
5637142-4	1968	In 10 subjects given 10-20 mU of vasopressin per hr during phases 2 and 3, free water clearance decreased significantly from phase 1 to phase 2 (9.3 to 0.15, P = 0.001) and increased during phase 3 norepinephrine infusion to 4.7 ml/min (P = 0.001).	Norepinephrine	198-212	arginine vasopressin	Homo sapiens	33-44
5637142-8	1968	A post-phase 3 infusion of vasopressin in four subjects resulted in a marked decrease in free water clearance, indicating that the norepinephrine inhibition of vasopressin antidiuresis was not accountable on the basis of decreased medullary hypertonicity.	Norepinephrine	131-145	arginine vasopressin	Homo sapiens	160-171
5637142-7	1968	The magnitude of the (phase 3) norepinephrine-induced increase in free water clearance (4.5 +/- 0.64 ml/min) during infusion of 10-20 mU of vasopressin per hr, the failure of norepinephrine to increase free water clearance during infusion of 50-100 mU of vasopressin per hr, and the relatively constant endogenous creatinine and osmolal clearance rates would suggest that the norepinephrine inhibition of vasopressin antidiuresis was not the result of alterations in renal blood flow.	Norepinephrine	31-45	arginine vasopressin	Homo sapiens	140-151
5637142-7	1968	The magnitude of the (phase 3) norepinephrine-induced increase in free water clearance (4.5 +/- 0.64 ml/min) during infusion of 10-20 mU of vasopressin per hr, the failure of norepinephrine to increase free water clearance during infusion of 50-100 mU of vasopressin per hr, and the relatively constant endogenous creatinine and osmolal clearance rates would suggest that the norepinephrine inhibition of vasopressin antidiuresis was not the result of alterations in renal blood flow.	Norepinephrine	31-45	arginine vasopressin	Homo sapiens	255-266
5637142-7	1968	The magnitude of the (phase 3) norepinephrine-induced increase in free water clearance (4.5 +/- 0.64 ml/min) during infusion of 10-20 mU of vasopressin per hr, the failure of norepinephrine to increase free water clearance during infusion of 50-100 mU of vasopressin per hr, and the relatively constant endogenous creatinine and osmolal clearance rates would suggest that the norepinephrine inhibition of vasopressin antidiuresis was not the result of alterations in renal blood flow.	Norepinephrine	31-45	arginine vasopressin	Homo sapiens	255-266
6020215-0	1967	Blockade of release of growth hormone by brain norepinephrine depletors.	Norepinephrine	47-61	growth hormone 1	Homo sapiens	23-37
5640175-0	1968	Catecholamine and acetylcholinesterase distribution in relation to noradrenaline release.	Norepinephrine	67-80	acetylcholinesterase (Cartwright blood group)	Homo sapiens	18-38
6076307-0	1967	Effect of chronic hypogastric denervation on the noradrenaline content of the vas deferens and the accessory male reproductive glands of the rat.	Norepinephrine	49-62	arginine vasopressin	Rattus norvegicus	78-81
4382642-0	1967	Potentiation of noradrenaline isomers by cocaine and desipramine in the isolated vas deferens of the rat.	Norepinephrine	16-29	arginine vasopressin	Rattus norvegicus	81-84
6021207-2	1967	Despite concurrent increases in arterial blood pressure, the plasma renin activity of normal subjects increased both in response to the infusion of catecholamines (norepinephrine: epinephrine, 10:1) and in response to stimulation of the sympathetic nervous system by cold.	Norepinephrine	164-178	renin	Homo sapiens	68-73
14101528-0	1963	REMOVAL OF INFUSED NOREPINEPHRINE BY THE CAT"S SPLEEN; MECHANISM OF ITS INHIBITION BY PHENOXYBENZAMINE.	Norepinephrine	19-33	PICALM interacting mitotic regulator	Homo sapiens	41-46
6030509-16	1967	Responses to noradrenaline of uteri from oestradiol-treated rabbits were potentiated by vasopressin and by sodium fluoride, but not by theophylline or iminazole.	Norepinephrine	13-26	arginine vasopressin	Rattus norvegicus	88-99
5327883-0	1966	Inhibition of insulin release by norepinephrine in man.	Norepinephrine	33-47	insulin	Homo sapiens	14-21
5327883-2	1966	Immunoreactive insulin concentration was less than expected during the infusions of norepinephrine, but returned to higher values after the norepinephrine infusions.	Norepinephrine	84-98	insulin	Homo sapiens	15-22
5327883-2	1966	Immunoreactive insulin concentration was less than expected during the infusions of norepinephrine, but returned to higher values after the norepinephrine infusions.	Norepinephrine	140-154	insulin	Homo sapiens	15-22
5327883-3	1966	From these data it is concluded that norepinephrine inhibits the release of insulin from pancreatic beta cells.	Norepinephrine	37-51	insulin	Homo sapiens	76-83
14301015-0	1965	POTENTIATION OF NOREPINEPHRINE IN THE ISOLATED VAS DEFERENS OF THE RAT BY SOME CNS STIMULANTS AND ANTIDEPRESSANTS.	Norepinephrine	16-30	arginine vasopressin	Rattus norvegicus	47-50
14311457-0	1964	[EFFECT OF SYNTHETIC ANGIOTENSIN-II ON THE ARTERIAL PRESSURE OF DIFFERENT KINDS OF LABORATORY ANIMALS AND COMPARATIVE STUDY OF THIS ACTION WITH ADRENALINE AND NORADRENALINE].	Norepinephrine	159-172	angiotensinogen	Homo sapiens	21-35
13972981-0	1963	[Action of insulin on the noradrenaline in the adrenal medulla.	Norepinephrine	26-39	insulin	Homo sapiens	11-18
13798429-3	1960	The responses of the nictitating membrane to adrenaline, noradrenaline and tyramine were potentiated by substance P as well.	Norepinephrine	57-70	tachykinin precursor 1	Homo sapiens	104-115
13526857-0	1957	[Storage of adrenalin &amp; noradrenalin in the chromaffin granules of the adrenal medulla &amp; the effect of reserpine &amp; insulin].	Norepinephrine	28-40	insulin	Homo sapiens	127-134
13210192-0	1954	Noradrenalin in anaphylactic shock from insulin; report of a case.	Norepinephrine	0-12	insulin	Homo sapiens	40-47
13211887-0	1954	The effect of insulin on the levels of adrenalin and noradrenaline in human blood.	Norepinephrine	53-66	insulin	Homo sapiens	14-21
33751565-6	2021	In vitro, the treatments of MDSCs with epinephrine (EPI) and norepinephrine (NE) but not corticosterone (CORT) treated H22 conditioned medium obviously inhibited T cell proliferation, as well as enhanced CXCR2 expression and Erk phosphorylation.	Norepinephrine	61-75	mitogen-activated protein kinase 1	Mus musculus	225-228
14777865-0	1950	Adrenaline and noradrenaline in the suprarenal medulla after insulin.	Norepinephrine	15-28	insulin	Homo sapiens	61-68
33127424-0	2021	Altered behaviour, dopamine and norepinephrine regulation in stressed mice heterozygous in TPH2 gene.	Norepinephrine	32-46	tryptophan hydroxylase 2	Mus musculus	91-95
32473788-5	2021	Norepinephrine stimulates both subtypes of alpha receptors and beta1 receptors.	Norepinephrine	0-14	BCL2 related protein A1	Homo sapiens	63-68
33582931-4	2021	Knocking down of Nrf1 in the PVN of 2K1C rats can significantly reduce their blood pressure and level of plasma norepinephrine (NE).	Norepinephrine	112-126	nuclear respiratory factor 1	Rattus norvegicus	17-21
33851554-5	2021	Further substantiating this observation, we show in mouse aortic rings that insulin exposure suppresses epinephrine and norepinephrine-induced vasoconstriction.	Norepinephrine	120-134	insulin	Homo sapiens	76-83
34039912-12	2021	CONCLUSION: These results demonstrate that aldosterone contributes to BP elevation and vascular norepinephrine sensitivity and remodeling caused by hET-1 overexpression in endothelium in mice.	Norepinephrine	96-110	endothelin 1	Homo sapiens	148-153
33677066-19	2021	In conventional ML but not in EHT, maximum norepinephrine effects on cytosolic cAMP depend on PDE3 and PDE4, suggesting immaturity when compared to the situation in adult human atrial cardiomyocytes.	Norepinephrine	43-57	phosphodiesterase 4A	Homo sapiens	103-107
33677066-20	2021	The smaller ICa responses to norepinephrine in ML and EHT vs. adult human atrial cardiomyocytes depend at least partially on a non-physiological large impact of PDE4 in hiPSC-cardiomyocytes.	Norepinephrine	29-43	phosphodiesterase 4A	Homo sapiens	161-165
33964987-7	2021	A meta-analysis also reported that ultrashort-acting beta1-blockers increased stroke volume index, while it reduced heart rate, resulting in unchanged cardiac index, mean arterial pressure, and norepinephrine requirement at 24 h, leading to an improvement of cardiovascular efficiency.	Norepinephrine	194-208	BCL2 related protein A1	Homo sapiens	53-58
33990796-0	2021	APOE4 provokes tau aggregation via inhibition of noradrenaline transport.	Norepinephrine	49-62	apolipoprotein E	Homo sapiens	0-5
33929079-5	2021	In other experiments, trabeculae were observed for spontaneous contractions and cumulative concentration-effect curves were established to (-)-noradrenaline at beta1 -ARs in the absence or presence of OM.	Norepinephrine	143-156	BCL2 related protein A1	Homo sapiens	160-165
34017842-5	2021	Methods: We retrospectively analyzed consecutive cases of septic shock for which vasopressin was introduced with loading under noradrenaline at >0.2 mug/kg/min during the study period.	Norepinephrine	127-140	arginine vasopressin	Homo sapiens	81-92
33737458-8	2021	The present study reveals a synapse-specific regulatory mechanism recruited by norepinephrine (NE) signaling within parvalbumin-expressing interneuron (PV-IN) feedforward inhibitory microcircuits.	Norepinephrine	79-93	parvalbumin	Mus musculus	116-127
33853276-0	2021	Is the autonomic nervous system explaining norepinephrine requirements decrease in septic shock patients following administration of alpha-2 agonists?	Norepinephrine	43-57	glycoprotein hormone subunit alpha 2	Homo sapiens	133-140
33915109-4	2021	Intravital two-photon imaging after injection of noradrenaline revealed transient inhibition of CD8+ and CD4+ T cell locomotion in tissues.	Norepinephrine	49-62	CD4 molecule	Homo sapiens	105-108
33315681-2	2021	We identified 2 cases with remarkably changed pulmonary uptake between 2 metaiodobenzylguanidine scintigraphies; pulmonary uptake was reduced when patients were taking selective serotonin reuptake inhibitor/serotonin noradrenaline reuptake inhibitor and preserved during the medication-naive or withdrawal state, suggesting that pulmonary uptake involves not only the noradrenaline transporter, but also the serotonin transporter.	Norepinephrine	217-230	solute carrier family 6 member 2	Homo sapiens	368-393
33854357-5	2021	Both WT and MIF-KO mice presented similar left ventricular contractility, peri-infarct myocardial fibrosis and sympathetic reinnervation, and circulating and local norepinephrine levels during the acute phase of MI.	Norepinephrine	164-178	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	12-15
33315681-2	2021	We identified 2 cases with remarkably changed pulmonary uptake between 2 metaiodobenzylguanidine scintigraphies; pulmonary uptake was reduced when patients were taking selective serotonin reuptake inhibitor/serotonin noradrenaline reuptake inhibitor and preserved during the medication-naive or withdrawal state, suggesting that pulmonary uptake involves not only the noradrenaline transporter, but also the serotonin transporter.	Norepinephrine	217-230	solute carrier family 6 member 4	Homo sapiens	408-429
33529409-7	2021	Disrupted insulin signaling drives the hampered neurotransmission of serotonin, dopamine, and norepinephrine.	Norepinephrine	94-108	insulin	Homo sapiens	10-17
33529804-0	2021	Norepinephrine transporter expressed on mammary epithelial cells incorporates norepinephrine in milk into the cells.	Norepinephrine	78-92	solute carrier family 6 member 2	Homo sapiens	0-26
33515564-10	2021	Norepinephrine-elicited muscle contraction was reduced in RyR1+/- aortic and pulmonary arteries.	Norepinephrine	0-14	ryanodine receptor 1, skeletal muscle	Mus musculus	58-62
33841324-5	2021	Classically, the main signaling pathway known to activate thermogenesis in adipocytes is beta3-adrenergic signaling, which is activated by norepinephrine in response to cold, leading to activation of the thermogenic program and browning.	Norepinephrine	139-153	T cell immune regulator 1, ATPase H+ transporting V0 subunit a3	Homo sapiens	89-94
33735282-7	2021	High vWF:Ag was associated with systemic endothelial activation of older and obese patients with elevated SOFA score, increased norepinephrine and higher requirement of continuous renal replacement therapy without an effect on MO runtime and mortality.	Norepinephrine	128-142	von Willebrand factor	Homo sapiens	5-8
33735282-10	2021	Instead, WGT/high vWF:Ag presented older and more obese patients with a two-digit SOFA score, highest norepinephrine, and aggravated gas transfer.	Norepinephrine	102-116	von Willebrand factor	Homo sapiens	18-21
33737848-10	2021	Results: We found 24-hour urinary norepinephrine levels were associated with systolic and diastolic BP (SBP, beta=0.157, p=0.082; DBP, beta=0.212, p=0.023) and mean arterial pressure (MAP, beta=0.198, p=0.032) after adjusting for confounders.	Norepinephrine	34-48	D-box binding PAR bZIP transcription factor	Homo sapiens	130-133
33334813-7	2021	Intratumoral adrenergic nerves release noradrenaline to stimulate angiogenesis via vascular endothelial growth factor signaling and enhance the rate of tumor growth.	Norepinephrine	39-52	vascular endothelial growth factor A	Homo sapiens	83-117
33691909-1	2021	Cold-induced norepinephrine activates beta3-adrenergic receptors (beta3-AR) to stimulate the kinase cascade and cAMP-response element-binding protein, leading to the induction of thermogenic gene expression including uncoupling protein 1 (Ucp1).	Norepinephrine	13-27	adenosine A3 receptor	Mus musculus	66-74
33737848-12	2021	After adjusting for confounders, increased 24-hour urinary norepinephrine levels were significantly associated with elevated SBP (beta=0.454, p=0.012), DBP (beta=0.399, p=0.041), and MAP (beta=0.432, p=0.023) in normal weight, but not in overweight/obese patients (all p>0.2).	Norepinephrine	59-73	D-box binding PAR bZIP transcription factor	Homo sapiens	152-155
33665818-8	2021	Knockdown of Cx43 potentiated noradrenaline (NA)-induced expression of BDNF mRNA in cultured astrocytes.	Norepinephrine	30-43	gap junction protein, alpha 1	Rattus norvegicus	13-17
33367607-8	2021	Blocking neuronal lactate utilization improved the counterregulatory hormone responses in norepinephrine-treated animals, suggesting repeated activation of VMH beta2-adrenergic receptors increases local lactate levels which in turn, suppresses the counterregulatory hormone response to hypoglycemia.	Norepinephrine	90-104	UDP glucuronosyltransferase 1 family, polypeptide A7C	Rattus norvegicus	160-165
33002334-6	2021	Norepinephrine or epinephrine were used in the presence of the beta2 -selective antagonist (ICI 118,551, 50nM) or the beta1 -selective antagonist (CGP 20712A, 300 nM) to stimulate beta1 -AR or beta2 -AR, respectively.	Norepinephrine	0-14	ATPase H+ transporting V0 subunit a2	Homo sapiens	63-68
33002334-6	2021	Norepinephrine or epinephrine were used in the presence of the beta2 -selective antagonist (ICI 118,551, 50nM) or the beta1 -selective antagonist (CGP 20712A, 300 nM) to stimulate beta1 -AR or beta2 -AR, respectively.	Norepinephrine	0-14	BCL2 related protein A1	Homo sapiens	118-123
33002334-6	2021	Norepinephrine or epinephrine were used in the presence of the beta2 -selective antagonist (ICI 118,551, 50nM) or the beta1 -selective antagonist (CGP 20712A, 300 nM) to stimulate beta1 -AR or beta2 -AR, respectively.	Norepinephrine	0-14	BCL2 related protein A1	Homo sapiens	180-185
33481407-14	2021	We observed that epinephrine and norepinephrine induced actin cytoskeletal rearrangement and normalized the membrane expression of proteins involved with adherens-junctions (vascular endothelial-cadherin) and tight-junctions (zona occludens-1).	Norepinephrine	33-47	cadherin 5	Homo sapiens	174-203
33481407-14	2021	We observed that epinephrine and norepinephrine induced actin cytoskeletal rearrangement and normalized the membrane expression of proteins involved with adherens-junctions (vascular endothelial-cadherin) and tight-junctions (zona occludens-1).	Norepinephrine	33-47	tight junction protein 1	Homo sapiens	226-242
33481407-16	2021	CONCLUSIONS: Our findings demonstrate that treatment with epinephrine or norepinephrine strongly reduces endothelial permeability induced by agonists of multiple Toll-like receptors (Toll-like receptor-2, Toll-like receptor-3, Toll-like receptor-4) in vitro.	Norepinephrine	73-87	toll like receptor 2	Homo sapiens	183-203
33434145-7	2021	Exposure of excess norepinephrine significantly restricted the induced expression of decidualized markers Dtprp, BMP2, WNT4, and Hand2 in mice.	Norepinephrine	19-33	bone morphogenetic protein 2	Mus musculus	113-117
33434145-8	2021	In vitro, 10 microM norepinephrine markedly downregulated the expressions of prolactin, IGFBP1, and PLZF, which are the specifical markers of decidual stromal cells during decidualization.	Norepinephrine	20-34	zinc finger and BTB domain containing 16	Mus musculus	100-104
33708848-10	2021	Plasma norepinephrine and N-terminal pro-B-type-natriuretic peptide were significantly reduced in the UTMD-Ang1 group from day 1 to 1 month after MI.	Norepinephrine	7-21	angiopoietin 1	Canis lupus familiaris	107-111
32954502-0	2021	Noradrenaline protects neurons against H2 O2 -induced death by increasing the supply of glutathione from astrocytes via beta3 -adrenoceptor stimulation.	Norepinephrine	0-13	T cell immune regulator 1, ATPase H+ transporting V0 subunit a3	Homo sapiens	120-125
2879896-1	1987	An antiserum directed against tyrosine hydroxylase (TH), an enzyme involved in dopamine and norepinephrine synthesis, was used to visualize axons immunohistochemically in monkey neocortex.	Norepinephrine	92-106	tyrosine hydroxylase	Homo sapiens	30-50
2879896-1	1987	An antiserum directed against tyrosine hydroxylase (TH), an enzyme involved in dopamine and norepinephrine synthesis, was used to visualize axons immunohistochemically in monkey neocortex.	Norepinephrine	92-106	tyrosine hydroxylase	Homo sapiens	52-54
32954502-9	2021	MK571, which inhibits the export of GSH from astrocytes mediated by multidrug resistance-associated protein 1, also prevented the neuroprotective effect of noradrenaline.	Norepinephrine	156-169	ATP binding cassette subfamily C member 1	Homo sapiens	68-109
32954502-3	2021	Recently, we found that noradrenaline increased the intracellular GSH concentration in astrocytes via beta3 -adrenoceptor stimulation.	Norepinephrine	24-37	T cell immune regulator 1, ATPase H+ transporting V0 subunit a3	Homo sapiens	102-107
32954502-10	2021	These results suggest that noradrenaline protects neurons against H2 O2 -induced death by increasing the supply of GSH from astrocytes via beta3 -adrenoceptor stimulation.	Norepinephrine	27-40	T cell immune regulator 1, ATPase H+ transporting V0 subunit a3	Homo sapiens	139-144
32429680-13	2020	Although EA and pharmacological treatment did not differ in terms of pain relief, in vitro epinephrine and norepinephrine reduced TNF-alpha production in response to LPS stimuli.	Norepinephrine	107-121	tumor necrosis factor	Homo sapiens	130-139
33551812-2	2020	Many of these are inhibitors of the presynaptic noradrenaline, dopamine, and serotonin transporters (NET, DAT, and SERT).	Norepinephrine	48-61	solute carrier family 6 member 4	Homo sapiens	115-119
33220286-4	2021	KEY FINDINGS: In the cyclic animal in estrus, the treatment with Ant-VIP in the left ovarian bursa resulted in a reduction in testosterone serum levels and in ovarian levels of dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC), without changes in 4-hydroxy-3-methoxyphenyl (MHPG) and norepinephrine (NE).	Norepinephrine	286-300	vasoactive intestinal peptide	Rattus norvegicus	69-72
33459706-5	2021	Another insufficiently considered aspect of cerebral proinflammatory cytokines is the fitness of the endogenous cerebral anti-TNF system provided by norepinephrine (NE), generated and distributed throughout the brain from the locus coeruleus (LC).	Norepinephrine	149-163	tumor necrosis factor	Homo sapiens	126-129
33162095-8	2021	The research revealed that the GABAB-cyclic AMP-protein kinase A-cAMP-response element binding protein (GABAB-cAMP-PKA-CREB) signaling pathway was related to the depression-like symptoms and that levels of 5-hydroxytryptamine, norepinephrine, and dopamine in the hippocampus of mice increased after treatment with the adzuki bean sprout fermented milk.	Norepinephrine	227-241	cAMP responsive element binding protein 1	Mus musculus	119-123
33384769-11	2020	Adipocytes from mice lacking beta1-, beta2- and beta3-ARs (triple KO) also responded to millimolar doses of adrenaline or noradrenaline by activating hexose transport in the presence of 100 micromol/L vanadate.	Norepinephrine	122-135	brain protein 1	Mus musculus	29-53
33227660-3	2020	Insulin-induced hypoglycemia elicited a significant dynamic response of IL-6, adrenaline, noradrenaline, GH, prolactin, ACTH and serum and salivary cortisol (P < 0.001 for all variables).	Norepinephrine	90-103	insulin	Homo sapiens	0-7
33080415-11	2020	The more favorable neonatal acid-base profile of noradrenaline might be due to better maintenance of placental blood flow in the noradrenaline group due to its beta action, while the higher fetal glucose concentration in the same group might result from a catecholamine-stimulated glucose metabolism increase and a beta-receptor mediated insulin decrease.	Norepinephrine	49-62	insulin	Homo sapiens	338-345
33328856-7	2020	Chronic central IFN-alpha infusion significantly increased the cerebrospinal fluid (CSF) concentrations of noradrenaline (NA), and 3,4-dihydroxyphenylacetic acid (DOPAC), but not 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA).	Norepinephrine	107-120	interferon alpha 1	Homo sapiens	16-25
32827566-1	2021	Neuropeptide Y (NPY) is highly abundant in the brain and is released as a co-transmitter with plasticity-related neurotransmitters such as glutamate, GABA and noradrenaline.	Norepinephrine	159-172	neuropeptide Y	Rattus norvegicus	0-14
32827566-1	2021	Neuropeptide Y (NPY) is highly abundant in the brain and is released as a co-transmitter with plasticity-related neurotransmitters such as glutamate, GABA and noradrenaline.	Norepinephrine	159-172	neuropeptide Y	Rattus norvegicus	16-19
33324347-7	2020	Glucose intolerance on paraganglioma could be caused by increased insulin resistance mainly considering paraganglioma produces more norepinephrine than epinephrine.	Norepinephrine	132-146	insulin	Homo sapiens	66-73
32895018-5	2020	In control mice, Ang II infusion evoked a significant increase in blood pressure and norepinephrine excretion, along with polydipsia and polyuria.	Norepinephrine	85-99	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	17-23
32871155-0	2020	Corticotrophin releasing factor, but not alcohol, modulates norepinephrine release in the rat central nucleus of the amygdala.	Norepinephrine	60-74	corticotropin releasing hormone	Rattus norvegicus	0-31
33196051-12	2020	Our study showed that although there was no difference in mortality between the two groups, admission Sequential Organ Failure Assessment scores and admission lactate levels were found to be significantly higher in the norepinephrine-vasopressin group.	Norepinephrine	219-233	arginine vasopressin	Homo sapiens	234-245
33240096-3	2020	Norepinephrine, the main sympathetic neurotransmitter, is released at prejunctional neuroeffector junctions in the kidney and modulates renin release, renal vascular resistance, sodium and water handling, and immune cell response.	Norepinephrine	0-14	renin	Homo sapiens	136-141
32981364-10	2020	Collectively, our findings support the existence of a norepinephrine-activated alpha1-adrenoceptor gated pathway that relies on WNK/SPAK/OxSR1 signaling to regulate NCC activity in SSH.	Norepinephrine	54-68	oxidative stress responsive kinase 1	Rattus norvegicus	137-142
33020652-4	2020	Intrathecal norepinephrine induced mechanical pain hypersensitivity via alpha1A-ARs in Hes5+ astrocytes, and chemogenetic stimulation of Hes5+ SDH astrocytes was sufficient to produce the hypersensitivity.	Norepinephrine	12-26	serpin family A member 1	Homo sapiens	72-79
32893983-7	2020	The synthesis of cyclic PIP is stimulated by insulin and noradrenaline (alpha-receptor action).	Norepinephrine	57-70	prolactin induced protein	Rattus norvegicus	24-27
33245843-7	2020	Surprisingly, we found an enhanced contractility of tail and saphenous arteries from ANO1 heterozygous mice when stimulated with noradrenaline, vasopressin, and K+ -induced depolarization.	Norepinephrine	129-142	anoctamin 1, calcium activated chloride channel	Mus musculus	85-89
33282362-9	2020	The copeptin concentration following surgery was correlated to central venous pressure (P=0.03) and norepinephrine administered dose (P=0.008).	Norepinephrine	100-114	arginine vasopressin	Homo sapiens	4-12
32909219-3	2020	Our previous studies have shown that neonatal maternal deprivation (NMD) followed by adult multiple stress (AMS) advances the occurrence of visceral pain, likely due to enhanced norepinephrine (NE)-beta2 adrenergic signaling.	Norepinephrine	178-192	UDP glucuronosyltransferase 1 family, polypeptide A7C	Rattus norvegicus	198-203
33110450-5	2020	Results: Peroxisome proliferator activated receptor gamma- coactivator-1 alpha (PGC-1 alpha) and uncoupling protein 1 gene expression increased significantly in the normal weight group, but not in the overweight group, with norepinephrine treatment.	Norepinephrine	224-238	PPARG coactivator 1 alpha	Homo sapiens	80-91
33110450-5	2020	Results: Peroxisome proliferator activated receptor gamma- coactivator-1 alpha (PGC-1 alpha) and uncoupling protein 1 gene expression increased significantly in the normal weight group, but not in the overweight group, with norepinephrine treatment.	Norepinephrine	224-238	PPARG coactivator 1 alpha	Homo sapiens	9-78
33109226-7	2020	Moreover, patch-clamp recording using spinal slices showed that noradrenaline facilitated inhibitory synaptic inputs onto gastrin-releasing peptide receptor-expressing SDH neurons, a neuronal subset known to be essential for itch transmission.	Norepinephrine	64-77	itchy, E3 ubiquitin protein ligase	Mus musculus	225-229
32488425-10	2020	Vasopressin (median 4 IU/h) allowed a significant reduction of norepinephrine (0.18 [0.14-0.30] mcg/kg/min; p = 0.01), LVOT gradient (35 [24-60] mmHg; p = 0.01) and MR with a significant paO2/FiO2 increase (174 [125-213] mmHg; p = 0.01).	Norepinephrine	63-77	arginine vasopressin	Homo sapiens	0-11
32782145-7	2020	Interestingly, the SNS activity in iWAT of SC-specific Pten-deficient mice was reduced as demonstrated by decreased tyrosine hydroxylase (TH) expression level and neurotransmitters, such as norepinephrine (NE) and histamine (H).	Norepinephrine	190-204	phosphatase and tensin homolog	Mus musculus	55-59
32931196-8	2020	Angiotensin II caused a significant increase in mean arterial pressure and a rapid reduction in catecholamine vasopressor doses from 0.75 to 0.31 mcg/kg/min norepinephrine equivalents.	Norepinephrine	157-171	angiotensinogen	Homo sapiens	0-14
32488425-11	2020	CONCLUSION: Vasopressin allowed a reduction of norepinephrine with subsequent LVOTO reduction and hemodynamic improvement of the most severe form of LVOTO, which represented 1.9% of all septic shock patients.	Norepinephrine	47-61	arginine vasopressin	Homo sapiens	12-23
33205729-9	2020	Noradrenaline is the preferred vasopressor of choice for hypotension caused by quetiapine overdose, as it has less affinity for alpha2- and beta2-receptors, but maintains alpha1-receptor agonism.	Norepinephrine	0-13	glycoprotein hormone subunit alpha 2	Homo sapiens	128-134
32275785-0	2020	Norepinephrine stabilizes translation-dependent, homosynaptic long-term potentiation through mechanisms requiring the cAMP sensor Epac, mTOR and MAPK.	Norepinephrine	0-14	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	130-134
32275785-7	2020	Norepinephrine mediated enhancement of LTP was reduced by inhibition of mTOR and Epac but not PKA, suggesting that the endogenous beta-AR ligand norepinephrine may preferentially recruit Epac signaling to promote enduring changes in synaptic strength.	Norepinephrine	0-14	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	81-85
32275785-7	2020	Norepinephrine mediated enhancement of LTP was reduced by inhibition of mTOR and Epac but not PKA, suggesting that the endogenous beta-AR ligand norepinephrine may preferentially recruit Epac signaling to promote enduring changes in synaptic strength.	Norepinephrine	0-14	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	187-191
32275785-7	2020	Norepinephrine mediated enhancement of LTP was reduced by inhibition of mTOR and Epac but not PKA, suggesting that the endogenous beta-AR ligand norepinephrine may preferentially recruit Epac signaling to promote enduring changes in synaptic strength.	Norepinephrine	145-159	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	81-85
32275785-7	2020	Norepinephrine mediated enhancement of LTP was reduced by inhibition of mTOR and Epac but not PKA, suggesting that the endogenous beta-AR ligand norepinephrine may preferentially recruit Epac signaling to promote enduring changes in synaptic strength.	Norepinephrine	145-159	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	187-191
32829665-1	2020	Here, we tested the hypothesis that TNAP (tissue nonspecific alkaline phosphatase) modulates vascular responsiveness to norepinephrine.	Norepinephrine	120-134	alkaline phosphatase, biomineralization associated	Rattus norvegicus	36-40
32829665-1	2020	Here, we tested the hypothesis that TNAP (tissue nonspecific alkaline phosphatase) modulates vascular responsiveness to norepinephrine.	Norepinephrine	120-134	alkaline phosphatase, biomineralization associated	Rattus norvegicus	42-81
32829665-6	2020	Since in the rat mesenteric vasculature alpha1-adrenoceptors mediate norepinephrine-induced vasoconstriction, these finding indicate that TNAP inhibition selectively interferes with alpha1-adrenoceptor signaling.	Norepinephrine	69-83	alkaline phosphatase, biomineralization associated	Rattus norvegicus	138-142
32829665-7	2020	Additional experiments showed that the effects of TNAP inhibition on norepinephrine-induced vasoconstriction were not mediated by accumulation of pyrophosphate or ATP (TNAP substrates) nor by reduced adenosine levels (TNAP product).	Norepinephrine	69-83	alkaline phosphatase, biomineralization associated	Rattus norvegicus	50-54
32829665-8	2020	TNAP inhibition significantly reduced the Hillslope of the norepinephrine concentration versus vasoconstriction relationship from 1.8+-0.2 (consistent with positive cooperativity of alpha1-adrenoceptor signaling) to 1.0+-0.1 (no cooperativity).	Norepinephrine	59-73	alkaline phosphatase, biomineralization associated	Rattus norvegicus	0-4
32829665-11	2020	TNAP modulates vascular responses to norepinephrine likely by affecting positive cooperativity of alpha1-adrenoceptor signaling via a mechanism involving A1 receptor signaling.	Norepinephrine	37-51	alkaline phosphatase, biomineralization associated	Rattus norvegicus	0-4
32520577-7	2020	In LPS-challenged volunteers, norepinephrine enhanced plasma IL-10 concentrations and attenuated the release of the proinflammatory cytokine IFN-gamma-induced protein 10.	Norepinephrine	30-44	interleukin 10	Mus musculus	61-66
33117176-3	2020	They are related to two other adrenergic receptor families that also bind norepinephrine and epinephrine, the beta- and alpha2-, each with three subtypes (beta1, beta2, beta3, alpha2A, alpha2B, alpha2C).	Norepinephrine	74-88	G protein-coupled receptor 162	Homo sapiens	120-126
33117176-3	2020	They are related to two other adrenergic receptor families that also bind norepinephrine and epinephrine, the beta- and alpha2-, each with three subtypes (beta1, beta2, beta3, alpha2A, alpha2B, alpha2C).	Norepinephrine	74-88	G protein-coupled receptor 162	Homo sapiens	162-167
33117176-3	2020	They are related to two other adrenergic receptor families that also bind norepinephrine and epinephrine, the beta- and alpha2-, each with three subtypes (beta1, beta2, beta3, alpha2A, alpha2B, alpha2C).	Norepinephrine	74-88	immunoglobulin kappa variable 2D-28	Homo sapiens	169-174
33042003-7	2020	Also, the STZ-treated ghrelin-KO mice exhibited attenuated plasma epinephrine and norepinephrine responses to the insulin-induced hypoglycemia.	Norepinephrine	82-96	insulin	Homo sapiens	114-121
32424539-6	2020	The increased deposition of collagen I, fibronectin and periostin within the islet is associated with diminished islet perfusion as well as impaired capillary responses to noradrenaline (norepinephrine) and to high glucose in living pancreas slices.	Norepinephrine	172-185	periostin, osteoblast specific factor	Mus musculus	56-65
32984826-3	2020	Angiotensin II was initiated when the patient was requiring 2.2 microg/kg/min norepinephrine equivalents of vasopressor support, resulting in a prompt increase in the perfusion pressure.	Norepinephrine	78-92	angiotensinogen	Homo sapiens	0-14
32772437-2	2020	Here, we report that a single injection of norepinephrine (NE; 1 mg kg-1 ; s.c) attenuated the fasting-induced up-regulation of FoxO-target genes in tibialis anterior (TA) muscles by the stimulation of PKA/CREB and Akt/FoxO1 signaling pathways.	Norepinephrine	43-57	cAMP responsive element binding protein 1	Mus musculus	206-210
32772437-2	2020	Here, we report that a single injection of norepinephrine (NE; 1 mg kg-1 ; s.c) attenuated the fasting-induced up-regulation of FoxO-target genes in tibialis anterior (TA) muscles by the stimulation of PKA/CREB and Akt/FoxO1 signaling pathways.	Norepinephrine	43-57	thymoma viral proto-oncogene 1	Mus musculus	215-218
32397701-1	2020	The human norepinephrine transporter (hNET) is a transmembrane protein responsible for reuptake of norepinephrine in presynaptic sympathetic nerve terminals and adrenal chromaffin cells.	Norepinephrine	10-24	solute carrier family 6 member 2	Homo sapiens	38-42
32397701-3	2020	Molecular imaging of these tumors can be done using radiolabeled norepinephrine analogs that target hNET.	Norepinephrine	65-79	solute carrier family 6 member 2	Homo sapiens	100-104
32424539-6	2020	The increased deposition of collagen I, fibronectin and periostin within the islet is associated with diminished islet perfusion as well as impaired capillary responses to noradrenaline (norepinephrine) and to high glucose in living pancreas slices.	Norepinephrine	187-201	periostin, osteoblast specific factor	Mus musculus	56-65
32643759-0	2020	Alpha2A-adrenoceptor deficiency attenuates lipopolysaccharide-induced lung injury by increasing norepinephrine levels and inhibiting alveolar macrophage activation in acute respiratory distress syndrome.	Norepinephrine	96-110	adrenergic receptor, alpha 2a	Mus musculus	0-20
32360378-0	2020	Repeated norepinephrine receptor stimulation in the BNST induces sensorimotor gating deficits via corticotropin releasing factor.	Norepinephrine	9-23	corticotropin releasing hormone	Rattus norvegicus	98-128
32643759-8	2020	In vitro, we found that norepinephrine inhibited the production of TNF-alpha, IL-6, and CXCL2/MIP-2 and promoted the secretion of IL-10 from lipopolysaccharide-stimulated murine alveolar macrophages.	Norepinephrine	24-38	tumor necrosis factor	Mus musculus	67-76
32643759-8	2020	In vitro, we found that norepinephrine inhibited the production of TNF-alpha, IL-6, and CXCL2/MIP-2 and promoted the secretion of IL-10 from lipopolysaccharide-stimulated murine alveolar macrophages.	Norepinephrine	24-38	interleukin 6	Mus musculus	78-82
32643759-8	2020	In vitro, we found that norepinephrine inhibited the production of TNF-alpha, IL-6, and CXCL2/MIP-2 and promoted the secretion of IL-10 from lipopolysaccharide-stimulated murine alveolar macrophages.	Norepinephrine	24-38	chemokine (C-X-C motif) ligand 2	Mus musculus	88-93
32643759-8	2020	In vitro, we found that norepinephrine inhibited the production of TNF-alpha, IL-6, and CXCL2/MIP-2 and promoted the secretion of IL-10 from lipopolysaccharide-stimulated murine alveolar macrophages.	Norepinephrine	24-38	chemokine (C-X-C motif) ligand 2	Mus musculus	94-99
32643759-8	2020	In vitro, we found that norepinephrine inhibited the production of TNF-alpha, IL-6, and CXCL2/MIP-2 and promoted the secretion of IL-10 from lipopolysaccharide-stimulated murine alveolar macrophages.	Norepinephrine	24-38	interleukin 10	Mus musculus	130-135
32643759-10	2020	Furthermore, norepinephrine down-regulated NF-kappaB activation in stimulated alveolar macrophages.	Norepinephrine	13-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	43-52
32730300-9	2020	At the cellular level, cultured cells from brown adipose tissue (BAT) of Pdgfralpha-Cre Ahrfl/fl mice were more responsive than cells from controls to transcriptional activation of the thermogenic uncoupling protein 1 (Ucp1) gene by norepinephrine, suggesting an ability to burn more energy under certain conditions.	Norepinephrine	233-247	platelet derived growth factor receptor, alpha polypeptide	Mus musculus	73-83
32451082-1	2020	Noradrenaline (NA) suppresses TNF-alpha production via beta-adrenoceptors (ARs) in brain astrocytes.	Norepinephrine	0-13	tumor necrosis factor	Rattus norvegicus	30-39
32660596-1	2020	BACKGROUND: Currently, the diagnosis and treatment of neuroblastomas-the most frequent solid tumors in children-exploit the norepinephrine transporter (hNET) via radiolabeled norepinephrine analogs.	Norepinephrine	124-138	solute carrier family 6 member 2	Homo sapiens	152-156
32297203-8	2020	CONCLUSION: The data suggest that direct phosphorylation of glycerol by glycerokinase may be responsible for maintaining the supply of G3P for the existing rates of FA esterification and TAG synthesis in RWAT and EWAT from HFD-fed mice, contributing, along with a lower lipolytic response to norepinephrine, to higher adiposity.	Norepinephrine	292-306	glycerol kinase	Mus musculus	72-85
32382785-1	2020	RATIONALE: Synaptic neurotransmission with dopamine (DA), norepinephrine (NE), and serotonin (5-HT) is terminated primarily by reuptake into presynaptic terminals via the DA, NE, and 5-HT transporters (DAT/NET/SERT, respectively).	Norepinephrine	58-72	solute carrier family 6 member 4	Rattus norvegicus	210-214
32939891-4	2020	Norepinephrine (NE), the main sympathetic neurotransmitter, was found to promote TGF-beta1-induced epithelial-mesenchymal transition (EMT) and fibrotic gene expression in the human renal proximal epithelial cell line HK-2.	Norepinephrine	0-14	transforming growth factor beta 1	Homo sapiens	81-90
32151742-2	2020	Pharmacological norepinephrine transporter (NET) inhibition increases synaptic norepinephrine reuptake, which may be able to prevent hypotension, bradycardia, and syncope.	Norepinephrine	16-30	solute carrier family 6 member 2	Homo sapiens	44-47
32477156-8	2020	Conclusion: Our study results indicate that stellate ganglionectomy decreases cardiac norepinephrine release, which leads to decreased TGF-beta1 release and reduced fibrosis in rats with chronic volume overload.	Norepinephrine	86-100	transforming growth factor, beta 1	Rattus norvegicus	135-144
32774776-7	2020	This autonomic neuro-cardiogenic (ANCA) mechanism results in myocardial "cramp" (stunning), the severity and duration of which depend on the degree of the sympathetic-hyperactivation and nor-epinephrine spillover.	Norepinephrine	187-202	cathelicidin antimicrobial peptide	Homo sapiens	73-79
32339102-1	2020	BACKGROUND: Norepinephrine transporter (NET), which regulates synaptic norepinephrine for noradrenergic signaling, is involved in the pathogenesis of anxiety, while expression of the NET gene differs at different ages.	Norepinephrine	71-85	solute carrier family 6 member 2	Homo sapiens	12-38
32339102-1	2020	BACKGROUND: Norepinephrine transporter (NET), which regulates synaptic norepinephrine for noradrenergic signaling, is involved in the pathogenesis of anxiety, while expression of the NET gene differs at different ages.	Norepinephrine	71-85	solute carrier family 6 member 2	Homo sapiens	40-43
32339102-1	2020	BACKGROUND: Norepinephrine transporter (NET), which regulates synaptic norepinephrine for noradrenergic signaling, is involved in the pathogenesis of anxiety, while expression of the NET gene differs at different ages.	Norepinephrine	71-85	solute carrier family 6 member 2	Homo sapiens	183-186
32274584-7	2020	Most radiotracers targeting cardiac NET-function for the cardiac application consistent of derivatives of either norepinephrine or MIBG with its benzylguanidine core structure, e.g. 11C-HED and 18F-LMI1195.	Norepinephrine	113-127	solute carrier family 6 member 2	Homo sapiens	36-39
31912366-5	2020	Since AMPH is a transported inhibitor of both DAT and the norepinephrine transporter (NET), and EAAT3 is also expressed in norepinephrine (NE) neurons, we explored the possibility that this signaling cascade occurs in NE neurons.	Norepinephrine	58-72	solute carrier family 6 member 2	Homo sapiens	86-89
32486305-0	2020	Norepinephrine Inhibits the Proliferation of Human Bone Marrow-Derived Mesenchymal Stem Cells via beta2-Adrenoceptor-Mediated ERK1/2 and PKA Phosphorylation.	Norepinephrine	0-14	mitogen-activated protein kinase 3	Homo sapiens	126-132
32704560-8	2020	These VMH and peripheral glucose metabolism effects of circadian-timed bromocriptine may involve its known effect to reduce elevated VMH noradrenergic activity in insulin-resistant states as local VMH administration of norepinephrine was observed to significantly inhibit VMH GE neuronal sensing of local hyperglycaemia in insulin-sensitive animals on regular chow diet (52.4%).	Norepinephrine	219-233	insulin	Homo sapiens	163-170
32704560-8	2020	These VMH and peripheral glucose metabolism effects of circadian-timed bromocriptine may involve its known effect to reduce elevated VMH noradrenergic activity in insulin-resistant states as local VMH administration of norepinephrine was observed to significantly inhibit VMH GE neuronal sensing of local hyperglycaemia in insulin-sensitive animals on regular chow diet (52.4%).	Norepinephrine	219-233	insulin	Homo sapiens	323-330
32616947-9	2020	The mean dose of norepinephrine at the time of vasopressin initiation was 29.5 (SD 19.7) mug/min.	Norepinephrine	17-31	arginine vasopressin	Homo sapiens	47-58
32219097-7	2020	Moreover, LPD mice exhibited decreased concentrations of gamma-aminobutyric acid (GABA), glutamate, glycine, dopamine, norepinephrine, serotonin and aspartate in the brain.	Norepinephrine	119-133	acyl-CoA synthetase bubblegum family member 1	Mus musculus	10-13
32086857-3	2020	Norepinephrine (NE), via alpha1A ARs, activated a small conductance Ca2+ -activated K+ (SK) conductance, evoked outward currents and hyperpolarized PDGFRalpha+ cells (the alpha1A AR-SK channel signal pathway).	Norepinephrine	0-14	platelet derived growth factor receptor, alpha polypeptide	Mus musculus	148-158
32109626-5	2020	RESULTS: Serum CHGA levels were higher in the non-survivors group than in the survivors group (median (interquartile range): 434.8 (374.3-502.4) vs 183.3 (131.9-246.9) mug/l; p < 0.001) and were correlated with norepinephrine (r = 0.37. p < 0.001), blood glucose (r = 0.32, p = 0.001), lactate (r = 0.25, p = 0.009), WBC (r = 0.20, p = 0.039), and PRISM-III scores (r = 0.748, p < 0.0001).	Norepinephrine	211-225	chromogranin A	Homo sapiens	15-19
32043995-7	2020	The detection limits of noradrenaline, adrenaline, and dopamine were 0.1, 0.1, and 0.2 muM, respectively.	Norepinephrine	24-37	latexin	Homo sapiens	87-90
32281745-2	2020	This study investigates the effect of chronic administration of the serotonin-norepinephrine reuptake inhibitor, venlafaxine, on the expression and methylation status of SOD1, SOD2, GPx1, GPx4, CAT, NOS1 and NOS2 in the brain and blood of rats exposed to a chronic mild stress (CMS) model of depression.	Norepinephrine	78-92	superoxide dismutase 1	Rattus norvegicus	170-174
32199855-7	2020	RESULTS: Inhibition of Orai channels with YM-58483 (20 muM) significantly reduced norepinephrine-induced contractions in both HCC and HPRA from either No ED or ED subjects, but the effects were more marked in ED (-20.1 +- 5.9% vs -45.5 +- 13.2% and -15.9 +- 4.0% vs -31.4 +- 6.9% reduction in Emax to norepinephrine in HCC and HPRA, respectively).	Norepinephrine	82-96	latexin	Homo sapiens	55-58
32265469-8	2020	Although noradrenaline triggered a similar increase in intracellular lactate levels in astrocytes with and without TDP-43 inclusions, the probability of activating aerobic glycolysis was facilitated by 1.6-fold in astrocytes with TDP-43 inclusions and lactate MCT1 transporters were downregulated.	Norepinephrine	9-22	TAR DNA binding protein	Homo sapiens	230-236
32197418-7	2020	In addition, norepinephrine stimulation of isolated human IVD cells induced intracellular signaling via ERK1/2 and PKA.	Norepinephrine	13-27	mitogen-activated protein kinase 3	Homo sapiens	104-110
31785266-1	2020	Dopamine beta-hydroxylase (DBH) is one of key rate-limiting enzymes converting dopamine to norepinephrine.	Norepinephrine	91-105	dopamine beta-hydroxylase	Crassostrea gigas	0-25
32028998-10	2020	In such patients, a high ANG I/II ratio is associated with greater norepinephrine requirements and is an independent predictor of mortality, thus providing a biological rationale for interventions aimed at its correction.	Norepinephrine	67-81	angiotensinogen	Homo sapiens	25-30
32220188-0	2020	[Pathophysiological Study on Thoracic Ascending Aorta of Mice with Myh11 R247C Heterozygous Mutation in Norepinephrine-induced Hypertension Model].	Norepinephrine	104-118	myosin, heavy polypeptide 11, smooth muscle	Mus musculus	67-72
32220188-1	2020	Objevtive: To explore the thoracic ascending aortic (TAA) pathophysiological characteristics of heterozygous mutant Myh11 R247C/+ mice under the norepinephrine-induced hypertension mode.	Norepinephrine	145-159	myosin, heavy polypeptide 11, smooth muscle	Mus musculus	116-121
31751250-6	2020	The noise level of the on-chip read channel array allows amperometric detection of neurotransmitters such as norepinephrine (NE) with concentrations from 4muM to 512muM with 4.7pA/muM sensitivity ( R2=0.98).	Norepinephrine	109-123	latexin	Homo sapiens	155-158
31350035-6	2020	RESULTS: LRP1 expression was upregulated in both transverse aortic constriction (TAC)-induced hypertrophic myocardium and catecholamine (phenylephrine (PE) and norepinephrine (NE))- and angiotensin II (AngII)-induced hypertrophic cardiomyocytes.	Norepinephrine	160-174	LDL receptor related protein 1	Homo sapiens	9-13
31970567-8	2020	Clearly, vasopressin administration allows reducing norepinephrine requirements, but so far, no improvement of survival was reported and side effects are frequent, particularly ischaemic events.	Norepinephrine	52-66	arginine vasopressin	Homo sapiens	9-20
31689515-9	2020	The in vitro investigations of the effects of noradrenaline on microglia showed that noradrenaline through beta-adrenoceptor may influence Nrf2 expression also via CX3CR1-independent route.	Norepinephrine	46-59	NFE2 like bZIP transcription factor 2	Rattus norvegicus	139-143
31689515-9	2020	The in vitro investigations of the effects of noradrenaline on microglia showed that noradrenaline through beta-adrenoceptor may influence Nrf2 expression also via CX3CR1-independent route.	Norepinephrine	85-98	NFE2 like bZIP transcription factor 2	Rattus norvegicus	139-143
31689515-10	2020	The study suggests beta-adrenoceptor-mediated neuroinflammation-promoting role of noradrenaline in EAE via modulation of microglial Nrf2 expression, and thereby forms the basis for further translational pharmacological research to improve multiple sclerosis therapy.	Norepinephrine	82-95	NFE2 like bZIP transcription factor 2	Rattus norvegicus	132-136
31609018-6	2020	In cultured pinealocytes, Lhx4 expression was upregulated by cyclic AMP, a second messenger of norepinephrine.	Norepinephrine	95-109	LIM homeobox 4	Rattus norvegicus	26-30
31811856-3	2020	Noradrenaline increased alpha1B-adrenergic receptor-Rab5 interaction, which was blocked by paroxetine and by expression of the dominant-negative GRK2 mutant.	Norepinephrine	0-13	G protein-coupled receptor kinase 2	Homo sapiens	145-149
31792650-0	2020	Catestatin reverses the hypertrophic effects of norepinephrine in H9c2 cardiac myoblasts by modulating the adrenergic signaling.	Norepinephrine	48-62	chromogranin A	Homo sapiens	0-10
31792650-4	2020	We hypothesized that CST moderates the adrenergic overdrive and studied its effects on norepinephrine-mediated hypertrophic responses in H9c2 cardiac myoblasts.	Norepinephrine	87-101	chromogranin A	Homo sapiens	21-24
31792650-6	2020	When cells were pre-treated CST, it blunted the modulation of those genes by norepinephrine.	Norepinephrine	77-91	chromogranin A	Homo sapiens	28-31
31792650-9	2020	CST attenuated the immediate generation of ROS and the increase in glutathione peroxidase activity induced by norepinephrine treatment.	Norepinephrine	110-124	chromogranin A	Homo sapiens	0-3
31792650-11	2020	It showed that CST largely attenuates the stimulatory effects of norepinephrine and other mitogenic signals through the modulation of the gene regulatory modules in a characteristic manner.	Norepinephrine	65-79	chromogranin A	Homo sapiens	15-18
31669796-0	2019	The effects of varying Mg2+ ion concentrations on contractions to the cotransmitters ATP and noradrenaline in the rat vas deferens.	Norepinephrine	93-106	arginine vasopressin	Rattus norvegicus	118-121
31847911-4	2019	METHODS: We first looked at the spatial distribution of the noradrenaline (NA)-synthesizing enzyme, DBH (dopamine beta-hydroxylase), in comparison with NA receptors-beta1, beta2, and beta3 adrenergic receptors (beta1-AR, beta2-AR, and beta3-AR)-after which we examined the effects of the beta-blocker propranolol and alpha-blockers prazosin and yohimbine on stress-induced microglial activation.	Norepinephrine	60-73	dopamine beta hydroxylase	Mus musculus	100-103
31847911-4	2019	METHODS: We first looked at the spatial distribution of the noradrenaline (NA)-synthesizing enzyme, DBH (dopamine beta-hydroxylase), in comparison with NA receptors-beta1, beta2, and beta3 adrenergic receptors (beta1-AR, beta2-AR, and beta3-AR)-after which we examined the effects of the beta-blocker propranolol and alpha-blockers prazosin and yohimbine on stress-induced microglial activation.	Norepinephrine	60-73	dopamine beta hydroxylase	Mus musculus	105-130
31669796-1	2019	The vas deferens responds to a single electrical pulse with a biphasic contraction caused by cotransmitters ATP and noradrenaline.	Norepinephrine	116-129	arginine vasopressin	Rattus norvegicus	4-7
32186162-10	2019	Finally, we find that kidney invigoration method can change the concentrations of central neurotransmitters of norepinephrine and glutamate to regulate neuro-osteogenic network, and promote the recovery of ovarian function and have an estrogen-like effect by regulating the hypothalamus-pituitary-ovarian axis, which thus influences bone metabolism without clinically significant estrogen-like side effects, and regulate NPY, CGRP and SP involved in the bone metabolism.	Norepinephrine	111-125	calcitonin related polypeptide alpha	Homo sapiens	426-430
31381153-0	2019	Gap junctions coordinate the propagation of glycogenolysis induced by norepinephrine in the pineal gland.	Norepinephrine	70-84	RAS p21 protein activator 1	Rattus norvegicus	0-3
31381153-6	2019	Our data using glycogen and lactate quantification, electrical stimulation, and high-performance liquid chromatography with electrochemical detection, demonstrate that gap junctional communication between cells of the rat pineal gland allows cell-to-cell propagation of norepinephrine-induced signal that promotes glycogenolysis throughout the entire gland.	Norepinephrine	270-284	RAS p21 protein activator 1	Rattus norvegicus	168-171
31425733-4	2019	We found that epinephrine and norepinephrine up-regulate COX2 expression and PGD2 production through beta1-and beta2-ADRs.	Norepinephrine	30-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-61
31425733-4	2019	We found that epinephrine and norepinephrine up-regulate COX2 expression and PGD2 production through beta1-and beta2-ADRs.	Norepinephrine	30-44	prostaglandin D2 synthase	Homo sapiens	77-81
31425733-4	2019	We found that epinephrine and norepinephrine up-regulate COX2 expression and PGD2 production through beta1-and beta2-ADRs.	Norepinephrine	30-44	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	101-116
32186162-10	2019	Finally, we find that kidney invigoration method can change the concentrations of central neurotransmitters of norepinephrine and glutamate to regulate neuro-osteogenic network, and promote the recovery of ovarian function and have an estrogen-like effect by regulating the hypothalamus-pituitary-ovarian axis, which thus influences bone metabolism without clinically significant estrogen-like side effects, and regulate NPY, CGRP and SP involved in the bone metabolism.	Norepinephrine	111-125	tachykinin precursor 1	Homo sapiens	435-437
31646370-10	2019	In norepinephrine-refractory patients, vasopressin or epinephrine may be added.	Norepinephrine	3-17	arginine vasopressin	Homo sapiens	39-50
31931960-7	2019	Metaiodobenzylguanidine (MIBG) is a norepinephrine analog that undergoes active uptake by NET receptors resulting in accumulation in neuroblastoma as well as tissues normally expressing the NET receptor.	Norepinephrine	36-50	solute carrier family 6 member 2	Homo sapiens	90-93
31376444-5	2019	To characterize the functional interaction between MCH and the noradrenergic LC system, we also evaluated the neurochemical effects of MCH (100 ng) on the extracellular levels of noradrenaline (NA) in the medial prefrontal cortex (mPFC), an important LC terminal region involved in emotional processing.	Norepinephrine	179-192	oleoyl-ACP hydrolase	Rattus norvegicus	135-138
28820036-0	2019	Efficacy and Safety of the Early Addition of Vasopressin to Norepinephrine in Septic Shock.	Norepinephrine	60-74	arginine vasopressin	Homo sapiens	45-56
28820036-2	2019	Vasopressin may be added to norepinephrine to raise MAP or decrease norepinephrine dosage.	Norepinephrine	68-82	arginine vasopressin	Homo sapiens	0-11
28820036-3	2019	The purpose of this study was to determine whether early initiation of vasopressin to norepinephrine resulted in a reduced time to target MAP compared to norepinephrine monotherapy.	Norepinephrine	86-100	arginine vasopressin	Homo sapiens	71-82
28820036-3	2019	The purpose of this study was to determine whether early initiation of vasopressin to norepinephrine resulted in a reduced time to target MAP compared to norepinephrine monotherapy.	Norepinephrine	154-168	arginine vasopressin	Homo sapiens	71-82
31560870-0	2019	Prostaglandin E2 receptor EP3 subtype in the paraventricular hypothalamic nucleus mediates corticotropin-releasing factor-induced elevation of plasma noradrenaline levels in rats.	Norepinephrine	150-163	corticotropin releasing hormone	Rattus norvegicus	91-121
31692668-1	2019	The norepinephrine transporter (NET) is a Na+/Cl- coupled neurotransmitter transporter responsible for reuptake of released norepinephrine (NE) into nerve terminals in the brain, a key therapeutic used in the treatment of psychiatric disorders.	Norepinephrine	4-18	solute carrier family 6 member 2	Homo sapiens	32-35
31873938-6	2019	These pharmacotherapy aids to withdrawal and tapering opioid dosagadrenoceptor agonists that act through eNOS to inhibit norepinephrine.	Norepinephrine	121-135	nitric oxide synthase 3	Homo sapiens	105-109
31413360-5	2019	Like AICAR, an activator of AMPK, catecholamines (norepinephrine and isoproterenol) and SFAs (palmitate and stearate) significantly increased FGF21 production and release by cardiac myocytes via AMPK activation.	Norepinephrine	50-64	fibroblast growth factor 21	Homo sapiens	142-147
31631645-0	2019	Bradykinin and noradrenaline preconditioning influences level of antioxidant enzymes SOD, CuZn-SOD, Mn-SOD and catalase in the white matter of spinal cord in rabbits after ischemia/reperfusion.	Norepinephrine	15-28	catalase	Oryctolagus cuniculus	100-119
31631645-1	2019	The aim of present work is to assess the effects of bradykinin (Br) or noradrenaline (Nor) preconditioning to the levels of antioxidant enzymes: superoxide dismutase (SOD), copper, zinc superoxide dismutase (CuZn-SOD), manganese superoxide dismutase (Mn-SOD) and catalase in ischemia/reperfusion (I/R) model in the rabbit spinal cord white matter as well as effect on glial fibrillary acidic protein (GFAP) and ubiquitin immunoreaction in glial cells.	Norepinephrine	71-84	catalase	Oryctolagus cuniculus	263-271
31631645-1	2019	The aim of present work is to assess the effects of bradykinin (Br) or noradrenaline (Nor) preconditioning to the levels of antioxidant enzymes: superoxide dismutase (SOD), copper, zinc superoxide dismutase (CuZn-SOD), manganese superoxide dismutase (Mn-SOD) and catalase in ischemia/reperfusion (I/R) model in the rabbit spinal cord white matter as well as effect on glial fibrillary acidic protein (GFAP) and ubiquitin immunoreaction in glial cells.	Norepinephrine	86-89	catalase	Oryctolagus cuniculus	263-271
31356684-0	2019	STAT1-NFkappaB crosstalk triggered by interferon gamma regulates noradrenaline-induced pineal hormonal production.	Norepinephrine	65-78	nuclear factor kappa B subunit 1	Homo sapiens	6-14
31356684-0	2019	STAT1-NFkappaB crosstalk triggered by interferon gamma regulates noradrenaline-induced pineal hormonal production.	Norepinephrine	65-78	interferon gamma	Homo sapiens	38-54
31694361-8	2019	Plasma norepinephrine levels were significantly higher in RAIN than in CON at 10 minutes and from 40 to 60 minutes (P&lt;0.05).	Norepinephrine	7-21	Ras interacting protein 1	Homo sapiens	58-62
31631645-6	2019	Tissue catalase level activity was significantly decreased in the Br preconditioned group after 48 h of reperfusion (P&lt;0.05) and Nor preconditioned groups after 24 h of reperfusion (P&lt;0.001) and also after 48 h of reperfusion (P&lt;0.001), in comparison to ischemic group after 48 h of reperfusion.	Norepinephrine	132-135	catalase	Oryctolagus cuniculus	7-15
31631645-7	2019	Significantly decreased tissue catalase activity (P&lt;0.05) in both Nor preconditioned groups after 24 or 48 h of reperfusion was measured vs Br preconditioned group after 48 h of reperfusion.	Norepinephrine	69-72	catalase	Oryctolagus cuniculus	31-39
31603552-12	2019	The low levels of ARG, homoarginine, and citrulline may be the consequence of high circulating levels of alpha1 -agonists, such as epinephrine and norepinephrine, and their biochemical interaction with endothelial trace amine-associated receptor 1 that induces activation of NO synthase, resulting in NO synthesis in the circulation, NO release, intense vasodilation, and as a result, the cluster attack.	Norepinephrine	147-161	BCL2 related protein A1	Homo sapiens	105-111
28618919-2	2019	Norepinephrine is more easily titrated; however, septic shock is a vasopressin deficient state, which exogenous vasopressin endeavors to resolve.	Norepinephrine	0-14	arginine vasopressin	Homo sapiens	112-123
28618919-13	2019	CONCLUSION: Adult patients receiving norepinephrine and vasopressin in the resolving phase of septic shock may be less likely to develop clinically significant hypotension if vasopressin is the final vasopressor discontinued.	Norepinephrine	37-51	arginine vasopressin	Homo sapiens	175-186
31356684-2	2019	The nuclear translocation of nuclear factor kappa-B (NFkappaB) homodimers, lacking transactivation domains, once induced by lipopolysaccharide (LPS) or tumor necrosis factor (TNF), inhibits the expression of Aanat gene and the synthesis of noradrenaline (NA)-induced melatonin.	Norepinephrine	240-253	nuclear factor kappa B subunit 1	Homo sapiens	29-51
31356684-2	2019	The nuclear translocation of nuclear factor kappa-B (NFkappaB) homodimers, lacking transactivation domains, once induced by lipopolysaccharide (LPS) or tumor necrosis factor (TNF), inhibits the expression of Aanat gene and the synthesis of noradrenaline (NA)-induced melatonin.	Norepinephrine	240-253	nuclear factor kappa B subunit 1	Homo sapiens	53-61
31356684-2	2019	The nuclear translocation of nuclear factor kappa-B (NFkappaB) homodimers, lacking transactivation domains, once induced by lipopolysaccharide (LPS) or tumor necrosis factor (TNF), inhibits the expression of Aanat gene and the synthesis of noradrenaline (NA)-induced melatonin.	Norepinephrine	240-253	tumor necrosis factor	Homo sapiens	175-178
31422643-3	2019	CD4-positive T cells expressing beta2 adrenergic receptors and macrophages expressing the alpha 7 subunit of the nicotinic acetylcholine receptor in the spleen receive neurotransmitters such as norepinephrine and acetylcholine and are key mediators of the cholinergic anti-inflammatory pathway.	Norepinephrine	194-208	CD4 molecule	Homo sapiens	0-3
28750598-16	2019	CONCLUSION: Vasopressin discontinuation prior to cessation of norepinephrine infusion was associated with an increased risk of hemodynamic instability.	Norepinephrine	62-76	arginine vasopressin	Homo sapiens	12-23
31306490-0	2019	Angiotensin II mediates the axonal trafficking of tyrosine hydroxylase and dopamine beta-hydroxylase mRNAs and enhances norepinephrine synthesis in primary sympathetic neurons.	Norepinephrine	120-134	angiotensinogen	Rattus norvegicus	0-14
31306490-2	2019	At sympathetic nerve terminals, Ang II influences sympathetic transmission by enhancing norepinephrine (NE) synthesis, facilitating NE release and inhibiting NE uptake.	Norepinephrine	88-102	angiotensinogen	Rattus norvegicus	32-38
33654839-2	2019	Using these technologies, we recently showed that the dopamine beta-hydroxylase gene in Locus Coeruleus (LC) norepinephrine neurons plays a vital role in the maintenance of wakefulness.	Norepinephrine	109-123	dopamine beta hydroxylase	Mus musculus	54-79
31360296-8	2019	The protein kinase B/mammalian target of the rapamycin (Akt/mTOR) pathway which is involved in cardiac remodeling process was activated in response to norepinephrine and was mitigated by bucindolol.	Norepinephrine	151-165	AKT serine/threonine kinase 1	Homo sapiens	56-59
31039432-17	2019	In a multiple regression analysis, serum CRP levels were independently associated with serum cortisol (B = 4.5 x 10-4, p < 0.001), urine norepinephrine (B = 9.6 x 10-2, p = 0.044) and high-frequency power of heart rate variability (B = -3.7 x 10-2, p = 0.024).	Norepinephrine	137-151	C-reactive protein	Homo sapiens	41-44
30894696-8	2019	Similarly, the activity of dopamine beta-hydroxylase (DbetaH), the enzyme that converts dopamine to noradrenaline, was significantly increased in the adrenal glands of sik1-/- mice on a high-salt intake compared with sik1+/+ and sik1-/- mice on a control diet.	Norepinephrine	100-113	dopamine beta hydroxylase	Mus musculus	27-52
30894696-8	2019	Similarly, the activity of dopamine beta-hydroxylase (DbetaH), the enzyme that converts dopamine to noradrenaline, was significantly increased in the adrenal glands of sik1-/- mice on a high-salt intake compared with sik1+/+ and sik1-/- mice on a control diet.	Norepinephrine	100-113	dopamine beta hydroxylase	Mus musculus	54-60
31075414-2	2019	Recent evidence also indicates that norepinephrine neurotransmission can influence a series of psychophysical and psychobiological parameters related to athletic performance, and the presence of variants in the SLC6A2 (solute carrier family 6 member 2) gene, which encodes the norepinephrine transporter, can be detrimental to an adequate noradrenergic signaling.	Norepinephrine	36-50	solute carrier family 6 member 2	Homo sapiens	219-251
31075414-2	2019	Recent evidence also indicates that norepinephrine neurotransmission can influence a series of psychophysical and psychobiological parameters related to athletic performance, and the presence of variants in the SLC6A2 (solute carrier family 6 member 2) gene, which encodes the norepinephrine transporter, can be detrimental to an adequate noradrenergic signaling.	Norepinephrine	36-50	solute carrier family 6 member 2	Homo sapiens	277-303
30882962-3	2019	The present review has summarized the currently available pre-clinical and clinical data on the interactions of CB1 and cannabinoid type-2 receptors (CB2 ) with the central neurotransmitters; dopamine, serotonin, noradrenaline, GABA, glutamate and opioids.	Norepinephrine	213-226	cannabinoid receptor 1	Homo sapiens	112-115
31360296-8	2019	The protein kinase B/mammalian target of the rapamycin (Akt/mTOR) pathway which is involved in cardiac remodeling process was activated in response to norepinephrine and was mitigated by bucindolol.	Norepinephrine	151-165	mechanistic target of rapamycin kinase	Homo sapiens	60-64
31248037-0	2019	Norepinephrine Inhibits Synovial Adipose Stem Cell Chondrogenesis via alpha2a-Adrenoceptor-Mediated ERK1/2 Activation.	Norepinephrine	0-14	mitogen-activated protein kinase 3	Homo sapiens	100-106
31123076-6	2019	We also found catecholamine stress hormones noradrenaline and adrenaline were present in the dialysates and were apparently involved in enhancing the growth of the bacteria via transferrin iron provision.	Norepinephrine	44-57	transferrin	Homo sapiens	177-188
31528826-0	2019	Dipeptidyl Peptidase 4 Inhibition Increases Postprandial Norepinephrine via Substance P (NK1 Receptor) During RAAS Inhibition.	Norepinephrine	57-71	tachykinin precursor 1	Homo sapiens	76-87
31528826-12	2019	During treatment with an ACE inhibitor or angiotensin receptor blocker, DPP4 inhibition increased postprandial norepinephrine through a substance P receptor-dependent mechanism.	Norepinephrine	111-125	angiotensin I converting enzyme	Homo sapiens	25-28
30914244-1	2019	Nicotinic acetylcholine receptors (nAChR) are ion channels which regulate a numerous of neurotransmitters, including acetylcholine, norepinephrine, dopamine, serotonin and glutamate.	Norepinephrine	132-146	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	0-33
31161442-4	2019	RESULTS: The subgroup of patients whose angiotensin II dose was down-titrated from 20 ng kg-1 min-1 at treatment initiation to &lt;= 5 ng kg-1 min-1 at 30 min (79/163) had significantly lower endogenous serum angiotensin II levels and norepinephrine-equivalent doses and significantly higher MAP versus the &gt; 5 ng kg-1 min-1 subgroup (84/163).	Norepinephrine	235-249	angiotensinogen	Homo sapiens	40-54
30914244-1	2019	Nicotinic acetylcholine receptors (nAChR) are ion channels which regulate a numerous of neurotransmitters, including acetylcholine, norepinephrine, dopamine, serotonin and glutamate.	Norepinephrine	132-146	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	35-40
30714137-1	2019	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine, noradrenaline and adrenaline.	Norepinephrine	103-116	tyrosine hydroxylase	Homo sapiens	0-20
31009605-6	2019	Noradrenaline potency at beta1ARs was increased in AC6 KO.	Norepinephrine	0-13	adenylate cyclase 6	Mus musculus	51-54
30714137-1	2019	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine, noradrenaline and adrenaline.	Norepinephrine	103-116	tyrosine hydroxylase	Homo sapiens	22-24
30576626-0	2019	Glucocorticoid receptor deletion from locus coeruleus norepinephrine neurons promotes depression-like social withdrawal in female but not male mice.	Norepinephrine	54-68	nuclear receptor subfamily 3, group C, member 1	Mus musculus	0-23
30326265-6	2019	RESULTS: Ang II facilitated noradrenaline release in the vessels studied from MUN and CONTROL rats.	Norepinephrine	28-41	angiotensinogen	Rattus norvegicus	9-15
30629946-0	2019	Norepinephrine regulation of ventromedial hypothalamic nucleus metabolic transmitter biomarker and astrocyte enzyme and receptor expression: Impact of 5" AMP-activated protein kinase.	Norepinephrine	0-14	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	154-182
31156428-10	2019	In addition, noradrenaline is considered crucially involved in compensatory mechanisms, leading to increased Abeta degradation via several mechanisms, including microglia modulation.	Norepinephrine	13-26	amyloid beta precursor protein	Homo sapiens	109-114
30711897-12	2019	Overall, data reveal that stress exposure in male rats affects the regulation of brain IL-1beta by the norepinephrine-beta-AR pathway, while stress had no effect in the regulation of brain IL-1beta in female rats.	Norepinephrine	103-117	interleukin 1 alpha	Rattus norvegicus	87-95
29995172-3	2019	Tyrosine hydroxylase (TH), tetrahydrobiopterin (BH4)-dependent and iron-containing monooxygenase, catalyzes the conversion of L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA), which is the initial and rate-limiting step in the biosynthesis of catecholamines (DA, noradrenaline, and adrenaline).	Norepinephrine	266-279	tyrosine hydroxylase	Homo sapiens	0-20
31019023-7	2019	In a randomized, double-blind, placebo-controlled study in humans, consumption of a propionate-containing mixed meal resulted in a postprandial increase in plasma glucagon, FABP4, and norepinephrine, leading to insulin resistance and compensatory hyperinsulinemia.	Norepinephrine	184-198	insulin	Homo sapiens	211-218
29995172-3	2019	Tyrosine hydroxylase (TH), tetrahydrobiopterin (BH4)-dependent and iron-containing monooxygenase, catalyzes the conversion of L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA), which is the initial and rate-limiting step in the biosynthesis of catecholamines (DA, noradrenaline, and adrenaline).	Norepinephrine	266-279	tyrosine hydroxylase	Homo sapiens	22-24
30605312-0	2019	Norepinephrine Inhibits Alzheimer"s Amyloid-beta Peptide Aggregation and Destabilizes Amyloid-beta Protofibrils: A Molecular Dynamics Simulation Study.	Norepinephrine	0-14	amyloid beta precursor protein	Homo sapiens	36-48
30618087-0	2019	MicroRNA-7 inhibits melatonin synthesis by acting as a linking molecule between leptin and norepinephrine signaling pathways in pig pineal gland.	Norepinephrine	91-105	microRNA 7-2	Sus scrofa	0-10
31109431-5	2019	Recent studies have shown that vasopressin (AVP) improves hemodynamics, increases tissue perfusion, and synergizes with norepinephrine in patients with septic shock, showing extent application prospects in the treatment of septic shock.	Norepinephrine	120-134	arginine vasopressin	Homo sapiens	31-42
31109431-5	2019	Recent studies have shown that vasopressin (AVP) improves hemodynamics, increases tissue perfusion, and synergizes with norepinephrine in patients with septic shock, showing extent application prospects in the treatment of septic shock.	Norepinephrine	120-134	arginine vasopressin	Homo sapiens	44-47
30051353-7	2019	To test the hypothesis that LPS-elicited early loss of noradrenergic LC neurons may underlie this ascending pattern, we used a neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) to deplete brain norepinephrine.	Norepinephrine	208-222	toll-like receptor 4	Mus musculus	28-31
30861996-0	2019	Role of Norepinephrine in IL-1beta-Induced Chondrocyte Dedifferentiation under Physioxia.	Norepinephrine	8-22	interleukin 1 beta	Homo sapiens	26-34
30341700-6	2019	Activation of angiotensin II signaling in different brain sites such as the paraventricular nucleus (PVN), rostral ventrolateral medulla (RVLM), and area postrema (AP) may increase the release of norepinephrine, oxidative stress, and inflammation leading to increased cardiac contractility.	Norepinephrine	196-210	angiotensinogen	Homo sapiens	14-28
30341700-9	2019	In chronic HF, in peripheral regions, angiotensin II elevates both norepinephrine release and synthesis and inhibits norepinephrine uptake at nerve endings, which may contribute to the increase in sympathetic nerve activity.	Norepinephrine	67-81	angiotensinogen	Homo sapiens	38-52
30341700-9	2019	In chronic HF, in peripheral regions, angiotensin II elevates both norepinephrine release and synthesis and inhibits norepinephrine uptake at nerve endings, which may contribute to the increase in sympathetic nerve activity.	Norepinephrine	117-131	angiotensinogen	Homo sapiens	38-52
30394918-3	2019	alpha-2 adrenergic agonists have been reported to decrease norepinephrine requirements in experimental septic shock.	Norepinephrine	59-73	glycoprotein hormone subunit alpha 2	Homo sapiens	0-7
30707046-7	2019	The increased renal perfusion by CB2 receptor activation is also attributed to a direct vascular effect, since SMM-295 (5 muM) engendered a significant 37 +- 7% increase ( P &lt; 0.0001; n = 4) in luminal diameters of norepinephrine-preconstricted afferent arterioles.	Norepinephrine	218-232	cannabinoid receptor 2 (macrophage)	Mus musculus	33-36
30232529-1	2019	RATIONALE: Synthetic cathinones constitute a class of abused drugs that can act at dopamine, norepinephrine, and serotonin transporters (DAT, NET, and SERT, respectively).	Norepinephrine	93-107	solute carrier family 6 member 4	Rattus norvegicus	151-155
30760082-6	2019	In multivariate models, greater norepinephrine levels were associated with impaired iron transport (transferrin saturation &lt;20%, odds ratio=2.28; 95% CI [1.19-4.35]; P=0.013), but not with impaired iron storage (ferritin &lt;100 mug/L, odds ratio=1.25; 95% CI [0.73-2.16]; P=0.415).	Norepinephrine	32-46	transferrin	Homo sapiens	100-111
30760082-7	2019	Norepinephrine was a significant predictor of increased iron demand (soluble transferrin receptor, standardized beta-coefficient=0.12; P=0.006) and low transferrin saturation (standardized beta-coefficient=-0.12; P=0.003).	Norepinephrine	0-14	transferrin	Homo sapiens	77-88
30760082-7	2019	Norepinephrine was a significant predictor of increased iron demand (soluble transferrin receptor, standardized beta-coefficient=0.12; P=0.006) and low transferrin saturation (standardized beta-coefficient=-0.12; P=0.003).	Norepinephrine	0-14	transferrin	Homo sapiens	152-163
30828233-2	2019	Droxidopa is a synthetic amino acid analog that is directly metabolized to norepinephrine by dopa-decarboxylase, subsequently providing alpha and beta-agonist effects to increase blood pressure.	Norepinephrine	75-89	dopa decarboxylase	Homo sapiens	93-111
30394918-4	2019	The aim of the present study is to test the hypothesis that switching from sedation with propofol to the alpha-2 agonist dexmedetomidine may decrease norepinephrine doses in septic shock.	Norepinephrine	150-164	glycoprotein hormone subunit alpha 2	Homo sapiens	105-112
30247267-7	2019	The 2 populations also differed in responses to neuromodulators, with most SP cells, but few GRP cells, responding to noradrenaline and 5-HT; the converse was true for responses to the mu-opioid agonist DAMGO.	Norepinephrine	118-131	tachykinin precursor 1	Homo sapiens	75-77
30055194-4	2019	In contrast to NET, DAT and SERT, OCT3 has higher capacity and lower affinity for substrates, is sodium-independent, and is multi-specific, with the capacity to transport norepinephrine, dopamine, serotonin and histamine.	Norepinephrine	171-185	solute carrier family 6 member 4	Homo sapiens	28-32
30481553-6	2019	Hypoglycemic stimulation of norepinephrine activity in each site was impeded by compound C. Hypoglycemia caused drug-revocable (ARH) or -refractory (VMN, DMN) reductions in AMPK, alongside hindbrain AMPK-dependent augmentation of phospho-AMPK expression in each location.	Norepinephrine	28-42	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	173-177
30670757-0	2019	Norepinephrine-functionalised nanoflower-like organic silica as a new adsorbent for effective Pb(II) removal from aqueous solutions.	Norepinephrine	0-14	submaxillary gland androgen regulated protein 3B	Homo sapiens	94-100
30670757-1	2019	In order to remove Pb(II) ions efficiently from aqueous solutions, a new effective adsorbent of norepinephrine-functionalised nanoflower-like organic silica (NE-NFOS) was synthesised by a biomimetic method.	Norepinephrine	96-110	submaxillary gland androgen regulated protein 3B	Homo sapiens	19-25
30551424-10	2019	Furthermore, a one-week treatment of CPE (50 and 100 mg/kg) or fluoxetine also remarkably restored the serotonin and noradrenaline levels in the hippocampus as well as in the prefrontal cortex of the CUMS-exposed rats.	Norepinephrine	117-130	carboxypeptidase E	Rattus norvegicus	37-40
30481553-9	2019	Results show that DVC AMPK is required for hypoglycemic intensification of norepinephrine activity in characterized hypothalamic gluco-regulatory structures, and that this sensor regulates AMPK activation and metabolic effector transmission in those sites.	Norepinephrine	75-89	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	22-26
30411798-2	2019	Missense variants of human TH are associated with a recessive neurometabolic disease with low levels of brain dopamine and noradrenaline, resulting in a variable clinical picture, from progressive brain encephalopathy to adolescent onset DOPA-responsive dystonia (DRD).	Norepinephrine	123-136	tyrosine hydroxylase	Homo sapiens	27-29
31029854-10	2019	Doxycycline-induced tetNGN3-HIEs secreted serotonin, monocyte chemoattractant protein-1, glucose-dependent insulinotropic peptide, peptide YY, and ghrelin in response to norepinephrine and rotavirus infection, further supporting the presence of multiple EEC types.	Norepinephrine	170-184	peptide YY	Homo sapiens	131-141
30381083-5	2019	Urinary norepinephrine and serum insulin and leptin at day and night were increased in WT-WD and TRPV1-/--WD, with further elevation at night in TRPV1-/--WD.	Norepinephrine	8-22	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	97-102
30306640-8	2019	We found attenuated but significant Ca2+ release in response to application of norepinephrine to IP3 R2-KO astrocytes.	Norepinephrine	79-93	inositol 1,4,5-triphosphate receptor 2	Mus musculus	97-103
30462989-0	2019	Kv4.3 expression abrogates and reverses norepinephrine-induced myocyte hypertrophy by CaMKII inhibition.	Norepinephrine	40-54	potassium voltage-gated channel subfamily D member 3	Rattus norvegicus	0-5
30462989-3	2019	OBJECTIVE: We tested whether Kv4.3 expression can prevent or reverse cardiac hypertrophy induced by norepinephrine (NE).	Norepinephrine	100-114	potassium voltage-gated channel subfamily D member 3	Rattus norvegicus	29-34
30016400-7	2019	Norepinephrine (1 microM) decreased Epac1-expression, an effect blocked by prazosin, and increased FB collagen production.	Norepinephrine	0-14	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	36-41
31126701-5	2019	CONCLUSION: Our results suggest that the risk of hypotension is higher in patients with septic shock in whom vasopressin is withdrawn before norepinephrine.	Norepinephrine	141-155	arginine vasopressin	Homo sapiens	109-120
30457616-1	2018	Human norepinephrine and serotonin transporters (hNET and hSERT) are closely related monoamine transporters (MATs) that regulate neurotransmitter signaling in neurons and are primary targets for a wide range of therapeutic drugs used in the treatment of mood disorders.	Norepinephrine	6-20	solute carrier family 6 member 4	Homo sapiens	58-63
31061349-3	2019	In addition, indirect vascular contractions induced by noradrenaline (NA), the release of which is mediated through Ang II receptor type 1 (AT1) existing at the sympathetic nerve terminals (SNTs), also contribute to the vasopressor effects of Ang II.	Norepinephrine	55-68	angiotensinogen	Homo sapiens	116-122
30418879-5	2018	RESULTS: An obvious inflammatory response with a lipopolysaccharide concentration of 0.1 mg/L and an optimal repair effect with 1 muM norepinephrine were obtained.	Norepinephrine	134-148	latexin	Homo sapiens	130-133
30226612-0	2018	Norepinephrine enhances cell viability and invasion, and inhibits apoptosis of pancreatic cancer cells in a Notch-1-dependent manner.	Norepinephrine	0-14	notch receptor 1	Homo sapiens	108-115
30213630-0	2018	Norepinephrine induces rapid and long-lasting phosphorylation and redistribution of connexin 43 in cortical astrocytes.	Norepinephrine	0-14	gap junction protein, alpha 1	Mus musculus	84-95
30410974-6	2018	This signal was identified as norepinephrine, which was confirmed to stimulate invasion of ovarian cancer cells lacking wild-type p53.	Norepinephrine	30-44	tumor protein p53	Homo sapiens	130-133
29940406-0	2018	Predictive value of serum albumin levels on noradrenaline and fluid requirements in the first 24 h after admission to the Intensive Care Unit - A prospective observational study.	Norepinephrine	44-57	albumin	Homo sapiens	20-33
30245400-4	2018	Further vasorelaxant activity assessments revealed that these PDE5 inhibitors also exhibited significant angiectasis on the norepinephrine-precontracted 3rd-order mesenteric arteries (110-150 mum) via NO-sGC-cGMP pathway, implying their further application for the treatment of vascular diseases.	Norepinephrine	124-138	phosphodiesterase 5A	Homo sapiens	62-66
29940406-1	2018	PURPOSE: To determine the predictive value of serum albumin (SA) at admission to the intensive care unit (ICU) on the cumulative dose of noradrenaline, the fluids administered, the lactate level, and mortality during the first 24 h of ICU admission.	Norepinephrine	137-150	albumin	Homo sapiens	46-59
29859008-7	2018	KEY RESULTS: With receptor affinities set to published values, the 2R-1T model satisfactorily characterized the interaction between noradrenaline and arginine-vasopressin in rat small mesenteric arteries (relative standard error &lt;=20%), as well as the effect of phenoxybenzamine.	Norepinephrine	132-145	arginine vasopressin	Rattus norvegicus	159-170
30570030-1	2018	OBJECTIVE: To evaluate the short-term evolution of patients with septic shock refractory to norepinephrine treated with vasopressin in an intensive care unit of a university hospital.	Norepinephrine	92-106	arginine vasopressin	Homo sapiens	120-131
30570030-10	2018	The use of vasopressin in patients who are refractory to norepinephrine had little or no impact on mortality.	Norepinephrine	57-71	arginine vasopressin	Homo sapiens	11-22
30570030-11	2018	It was not possible to exclude the possibility that the high mortality in the present study was linked to the relatively late onset (after established refractoriness of norepinephrine) of vasopressin; this hypothesis should be further evaluated in a randomized study.	Norepinephrine	169-183	arginine vasopressin	Homo sapiens	188-199
29953881-3	2018	Several in vitro studies have shown inhibition of LPO activity by pharmaceutical compounds including commonly used antibiotics such as ampicillin and gentamicin, and molecules like prednisolone, norepinephrine, etc.	Norepinephrine	195-209	lactoperoxidase	Homo sapiens	50-53
29953881-5	2018	The aim of our study was the elucidation of the structural aspects of the inhibitory mechanism of ampicillin, gentamicin, amoxicillin, prednisolone and norepinephrine on LPO.	Norepinephrine	152-166	lactoperoxidase	Homo sapiens	170-173
30070610-6	2018	In a separate series of experiments, we show that insulin stimulates ULK1 phosphorylation at Ser757 (inhibitory site) in both hypoglycemic and euglycemic conditions, suggesting that counter-regulatory hormones (such as epinephrine, norepinephrine, growth hormone and glucagon) have limited effects on autophagy signaling in human skeletal muscle.	Norepinephrine	232-246	insulin	Homo sapiens	50-57
30170732-0	2018	Norepinephrine-induced downregulation of GLT-1 mRNA in rat astrocytes.	Norepinephrine	0-14	solute carrier family 1 member 2	Rattus norvegicus	41-46
30170732-4	2018	We hypothesized that norepinephrine is involved in the regulation of GLT-1.	Norepinephrine	21-35	solute carrier family 1 member 2	Rattus norvegicus	69-74
30170732-5	2018	The aim of this study was to investigate the effect of norepinephrine on GLT-1 expression in cultured astrocytes.	Norepinephrine	55-69	solute carrier family 1 member 2	Rattus norvegicus	73-78
30170732-11	2018	The in vitro study showed that norepinephrine and phenylephrine dose-dependently downregulated GLT-1 in primary astrocytes and RNB cells.	Norepinephrine	31-45	solute carrier family 1 member 2	Rattus norvegicus	95-100
30170732-13	2018	CONCLUSION: Norepinephrine downregulates GLT-1 mRNA expression in astrocytes via the alpha1-adrenoceptor.	Norepinephrine	12-26	solute carrier family 1 member 2	Rattus norvegicus	41-46
29753967-6	2018	By taking advantage of this fact, a sensitive probe was designed for determination of dopamine, adrenaline and noradrenaline with a limit of detection of 0.07, 0.60 and 0.01 muM, respectively.	Norepinephrine	111-124	latexin	Homo sapiens	174-177
29775703-2	2018	Previous studies have described the anatomical organization of NPY and CRF in the central nucleus of the amygdala, which sends CRF projections to the locus coeruleus (LC), activating LC norepinephrine release.	Norepinephrine	186-200	neuropeptide Y	Rattus norvegicus	63-66
30106035-2	2018	Noradrenaline inhibits microglial activation and suppresses pro-inflammatory mediator production (e.g., tumor necrosis factor-alpha, interleukin-1beta &amp; inducible nitric oxide synthase activity), thus limiting the cytotoxicity of midbrain dopaminergic neurons in response to an inflammatory stimulus.	Norepinephrine	0-13	tumor necrosis factor	Homo sapiens	104-131
30106035-2	2018	Noradrenaline inhibits microglial activation and suppresses pro-inflammatory mediator production (e.g., tumor necrosis factor-alpha, interleukin-1beta &amp; inducible nitric oxide synthase activity), thus limiting the cytotoxicity of midbrain dopaminergic neurons in response to an inflammatory stimulus.	Norepinephrine	0-13	interleukin 1 beta	Homo sapiens	133-150
29677047-1	2018	OBJECTIVES: Noradrenaline released from sympathetic nerves is rapidly inactivated via the action of the noradrenaline transporter (NET).	Norepinephrine	12-25	solute carrier family 6 member 2	Homo sapiens	104-129
29580890-1	2018	Increased proinflammatory cytokines, such as interleukin (IL)-1beta, may play an important role in the etiology of depression because they cause the hypothalamic-pituitary-adrenal axis to release glucocorticoids (GC) and induce dysfunction of serotonin and norepinephrine neurotransmission.	Norepinephrine	257-271	interleukin 1 beta	Rattus norvegicus	45-67
29689260-5	2018	Dopamine, norepinephrine and serotonin all decreased spiking of lOFC neurons in naive females via activation of Gialpha-coupled D2, alpha2-adrenergic and 5HT1A receptors, respectively.	Norepinephrine	10-24	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	132-159
29714043-14	2018	Predictive modelling through multivariable logistic regression analysis showed that female sex (odds ratio = 9.82) and increasing maximal response to noradrenaline (odds ratio = 1.19, per 1 mN increase) were associated with a higher probability of the occurrence of vasomotion, whereas increasing kidney function (expressed as estimated glomerular filtration rate) was associated with a lower probability (odds ratio = 0.97, per 1 ml min-1  (1.73 m)-2 ].	Norepinephrine	150-163	CD59 molecule (CD59 blood group)	Homo sapiens	434-439
29654295-4	2018	We tested in D2-/- mice the effect of etamicastat, a reversible peripheral inhibitor of dopamine-beta-hydroxylase that reduces the biosynthesis of norepinephrine from dopamine and decreases sympathetic nerve activity.	Norepinephrine	147-161	dopamine beta hydroxylase	Mus musculus	88-113
29377263-0	2018	The alpha1-adrenergic receptor is involved in hepcidin upregulation induced by adrenaline and norepinephrine via the STAT3 pathway.	Norepinephrine	94-108	signal transducer and activator of transcription 3	Mus musculus	117-122
29677047-1	2018	OBJECTIVES: Noradrenaline released from sympathetic nerves is rapidly inactivated via the action of the noradrenaline transporter (NET).	Norepinephrine	12-25	solute carrier family 6 member 2	Homo sapiens	131-134
29677047-2	2018	We aimed to determine whether a single nucleotide polymorphism (SNP) in the NET gene, rs7194256, was associated with blood pressure and plasma noradrenaline concentration in patients with resistant hypertension.	Norepinephrine	143-156	solute carrier family 6 member 2	Homo sapiens	76-79
29677047-10	2018	CONCLUSION: A SNP in the NET gene in patients with resistant hypertension is associated with higher plasma noradrenaline concentration and elevated SBP.	Norepinephrine	107-120	solute carrier family 6 member 2	Homo sapiens	25-28
29300091-3	2018	Pioneer studies provided valuable information on structure, function, and pharmacology of drugs targeting both hSERT and hNET (serotonin-norepinephrine reuptake inhibitors, SNRIs), and the differential binding mechanism between SNRIs and selective inhibitors of 5-HT (SSRIs) or NE (sNRIs) to their corresponding targets was expected to be able to facilitate the discovery of a privileged drug-like scaffold with improved efficacy.	Norepinephrine	137-151	solute carrier family 6 member 4	Homo sapiens	111-116
29867144-3	2018	Copper imaging and gene expression analysis in zebrafish identifies the locus coeruleus-norepinephrine (LC-NE) system, a vertebrate-specific neuromodulatory circuit critical for regulating sleep, arousal, attention, memory and emotion, as a copper-enriched unit with high levels of copper transporters CTR1 and ATP7A and the copper enzyme dopamine beta-hydroxylase (DBH) that produces NE.	Norepinephrine	88-102	ATPase copper transporting alpha	Danio rerio	311-316
29941879-5	2018	Compared to untreated controls in both OA and RA, TNF-treated iTH+ cells demonstrated a weaker staining of catecholaminergic markers in cell cultures of RA/OA patients, and the amount of produced noradrenaline was markedly lower.	Norepinephrine	196-209	tumor necrosis factor	Homo sapiens	50-53
29941879-9	2018	This study shows that TNF inhibits iTH+ synovial cells leading to the decrease of secreted noradrenaline.	Norepinephrine	91-104	tumor necrosis factor	Homo sapiens	22-25
29767741-5	2018	Molecularly, the enhancement of NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity in endothelial cells by neurotransmitters, such as noradrenaline and ATP, induces an enhanced production of pro-inflammatory mediators, including chemokines, which form immune cell gateways at specific vessels.	Norepinephrine	167-180	nuclear factor kappa B subunit 1	Homo sapiens	32-41
29868972-9	2018	Vasopressin and possibly angiotensin II may be useful owing to their norepinephrine-sparing effects.	Norepinephrine	69-83	arginine vasopressin	Homo sapiens	0-11
29868972-9	2018	Vasopressin and possibly angiotensin II may be useful owing to their norepinephrine-sparing effects.	Norepinephrine	69-83	angiotensinogen	Homo sapiens	25-39
29851841-1	2018	RATIONALE: The aromatic L-amino acid decarboxylase (AADC) deficiency (AADCD) is a rare, autosomal recessive neurometabolic disorder caused by a deficit of the AADC that is involved in serotonin and dopamine biosynthesis, causing as a consequence, their deficits, but also a lack of norepinephrine and epinephrine, given that dopamine is their precursor.	Norepinephrine	282-296	dopa decarboxylase	Homo sapiens	24-50
29851841-1	2018	RATIONALE: The aromatic L-amino acid decarboxylase (AADC) deficiency (AADCD) is a rare, autosomal recessive neurometabolic disorder caused by a deficit of the AADC that is involved in serotonin and dopamine biosynthesis, causing as a consequence, their deficits, but also a lack of norepinephrine and epinephrine, given that dopamine is their precursor.	Norepinephrine	282-296	dopa decarboxylase	Homo sapiens	52-56
29851841-1	2018	RATIONALE: The aromatic L-amino acid decarboxylase (AADC) deficiency (AADCD) is a rare, autosomal recessive neurometabolic disorder caused by a deficit of the AADC that is involved in serotonin and dopamine biosynthesis, causing as a consequence, their deficits, but also a lack of norepinephrine and epinephrine, given that dopamine is their precursor.	Norepinephrine	282-296	dopa decarboxylase	Homo sapiens	70-74
29300091-3	2018	Pioneer studies provided valuable information on structure, function, and pharmacology of drugs targeting both hSERT and hNET (serotonin-norepinephrine reuptake inhibitors, SNRIs), and the differential binding mechanism between SNRIs and selective inhibitors of 5-HT (SSRIs) or NE (sNRIs) to their corresponding targets was expected to be able to facilitate the discovery of a privileged drug-like scaffold with improved efficacy.	Norepinephrine	137-151	solute carrier family 6 member 2	Homo sapiens	121-125
29600824-2	2018	This trial was conducted to test the hypothesis that early concomitant treatment with vasopressin and norepinephrine reduces the time to achieve and maintain target MAP compared with initial norepinephrine monotherapy.	Norepinephrine	191-205	arginine vasopressin	Homo sapiens	86-97
29720569-2	2018	We tested whether phosphodiesterase 2A (PDE2A), which regulates the action of BNP-activated cyclic guanosine monophosphate (cGMP), was directly involved in modulating Ca2+ handling from stellate ganglia (SG) neurons and cardiac norepinephrine (NE) release in rats and humans with an enhanced sympathetic phenotype.	Norepinephrine	228-242	natriuretic peptide B	Rattus norvegicus	78-81
29600824-5	2018	Between March and June 2016, vasopressin was initiated within 4 hours of norepinephrine.	Norepinephrine	73-87	arginine vasopressin	Homo sapiens	29-40
29600824-8	2018	Patients treated with early concomitant vasopressin and norepinephrine more frequently had a positive culture (59% vs 37%, p=0.05) and grew nonlactose fermenting gram-negative bacilli (34% vs 10%, p=0.01) compared with patients treated with norepinephrine monotherapy, respectively.	Norepinephrine	241-255	arginine vasopressin	Homo sapiens	40-51
29600824-11	2018	CONCLUSION: Patients treated with early concomitant vasopressin and norepinephrine achieved and maintained MAP of 65 mm Hg faster than those receiving initial norepinephrine monotherapy, suggesting that overcoming vasopressin deficiency sooner may reduce the time patients spend in the early phase of septic shock.	Norepinephrine	68-82	arginine vasopressin	Homo sapiens	214-225
28668486-3	2018	However, this is not the case when glycogenolysis is activated by high potassium ion (K+) concentrations - possibly because noradrenaline in contrast to high K+ stimulates glycogenolysis by an increase not only in free cytosolic Ca2+ concentration ([Ca2+]i) but also in cyclic AMP (c-AMP), which may increase the expression of the monocarboxylate transporter through which it is released.	Norepinephrine	124-137	cathelicidin antimicrobial peptide	Homo sapiens	282-287
29198060-2	2018	MDMA produces cardiovascular and subjective stimulant effects that were shown to partially depend on the norepinephrine transporter (NET)-mediated release of norepinephrine and stimulation of alpha1-adrenergic receptors.	Norepinephrine	105-119	solute carrier family 6 member 2	Homo sapiens	133-136
29504268-4	2018	Second, the high Ang II dose exerted a novel differential effect on arterial contractile responsiveness to the sympathetic neurotransmitter, norepinephrine, depending on the level of sympathetic innervation.	Norepinephrine	141-155	angiotensinogen	Homo sapiens	17-23
29386392-3	2018	Here we develop human tyrosine hydroxylase (TH) promoter-controlled tetracycline-sensitive LRRK2 G2019S (GS) and LRRK2 G2019S kinase-dead (GS/DA) transgenic mice and show that LRRK2 GS expression leads to an age- and kinase-dependent cell-autonomous neurodegeneration of DA and norepinephrine (NE) neurons.	Norepinephrine	278-292	tyrosine hydroxylase	Homo sapiens	22-42
29386392-3	2018	Here we develop human tyrosine hydroxylase (TH) promoter-controlled tetracycline-sensitive LRRK2 G2019S (GS) and LRRK2 G2019S kinase-dead (GS/DA) transgenic mice and show that LRRK2 GS expression leads to an age- and kinase-dependent cell-autonomous neurodegeneration of DA and norepinephrine (NE) neurons.	Norepinephrine	278-292	leucine rich repeat kinase 2	Homo sapiens	91-96
28844165-5	2018	Mitochondrial F1-ATP synthase alpha-chain expression was decreased at 32  C compared to 37  C. Norepinephrine and at 32  C exposure, UCP-1 expression was increased but cytochrome-c oxidase and F1-ATP synthase alpha-chain expression was reduced with respect to 37  C. DISCUSSION: Sympathetic stimulation seems not to be the only factor associated with heat generation.	Norepinephrine	95-109	uncoupling protein 1	Rattus norvegicus	133-138
29406176-9	2018	The median weight and anaesthesia duration-adjusted dose of norepinephrine were 0.11 (0.00-0.45) ng kg-1 min-1 and 0.00 (0.00-0.00) kg-1 min-1 in the normal-saline and balanced-crystalloid groups, respectively (P=0.003).	Norepinephrine	60-74	CD59 molecule (CD59 blood group)	Homo sapiens	105-110
29427776-0	2018	Beta estradiol and norepinephrine treatment of differentiated SH-SY5Y cells enhances tau phosphorylation at (Ser396) and (Ser262) via AMPK but not mTOR signaling pathway.	Norepinephrine	19-33	mechanistic target of rapamycin kinase	Homo sapiens	147-151
29477944-8	2018	The further study indicated that the roles of CST-14 in mouse GI motility were significantly reversed by c-SOM (sstr1-5 antagonist), especially sstr2 and sstr3 and propranolol (beta-adrenoceptor blocker), suggesting that somatostatin system and noradrenaline system were involved in the inhibiting effects of CST-14 in GI.	Norepinephrine	245-258	somatostatin receptor 1	Mus musculus	112-117
29370734-6	2018	N-group showed higher urine noradrenaline (NA) level suggesting that these tissue signals are regulated by NA and Tshb.	Norepinephrine	28-41	thyroid stimulating hormone subunit beta	Rattus norvegicus	114-118
29175420-5	2018	In both systems, noradrenaline and the alpha1A-AR selective agonist A61603 stimulated glucose uptake by parallel pathways involving mTOR and AMPK, whereas another alpha1-AR agonist oxymetazoline increased glucose uptake predominantly by mTOR.	Norepinephrine	17-30	mechanistic target of rapamycin kinase	Homo sapiens	132-136
29175420-5	2018	In both systems, noradrenaline and the alpha1A-AR selective agonist A61603 stimulated glucose uptake by parallel pathways involving mTOR and AMPK, whereas another alpha1-AR agonist oxymetazoline increased glucose uptake predominantly by mTOR.	Norepinephrine	17-30	mechanistic target of rapamycin kinase	Homo sapiens	237-241
28786832-13	2018	Acute Physiology and Chronic Health Evaluation II score and an increase in norepinephrine infusion rate between days 1 and 3 were independently associated with area under curve I-FABP levels, whereas mean arterial pressure and creatinine levels were not.	Norepinephrine	75-89	fatty acid binding protein 2	Homo sapiens	177-183
29336676-6	2018	Epinephrine and vasopressin are appropriate second-line vasopressors and may enable use of lower doses of norepinephrine while improving hemodynamics.	Norepinephrine	106-120	arginine vasopressin	Homo sapiens	16-27
29386559-5	2018	Here we show that the adrenergic hormones epinephrine and norepinephrine induce PRL expression in the human monocytic cell line THP-1 at physiological concentrations.	Norepinephrine	58-72	prolactin	Homo sapiens	80-83
29938618-8	2018	Analysis of the vascular responsiveness showed an increased contractility response to norepinephrine in Ang II animals (Rmax: 70%), which was abolished by sildenafil through increased nitric oxide (NO) bioavailability and decreased reactive oxygen species (ROS) and vasoconstrictor prostanoids.	Norepinephrine	86-100	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	104-110
29233551-3	2018	We showed that continuing BMP4 and curtailing FGF2 in vitro, augmented with corticosteroid mimetic, induced these cells to upregulate the chromaffin cell-specific marker PNMT and other CA synthesis and storage markers, and we demonstrated noradrenaline and adrenaline by Faglu and high-performance liquid chromatography.	Norepinephrine	239-252	fibroblast growth factor 2	Homo sapiens	46-50
28893563-8	2018	Indeed, G2019S mice had altered basal levels and turnover of dopamine within the striatum, along with changes in hippocampal serotonin and norepinephrine activity in response to LPS and IFN-gamma.	Norepinephrine	139-153	interferon gamma	Mus musculus	186-195
29879885-5	2018	Plasma norepinephrine (NE) and brain natriuretic peptide [BNP, termed B-type natriuretic peptide-45 (BNP-45) in rats] are regulated by sympathetic nerve activity.	Norepinephrine	7-21	natriuretic peptide B	Rattus norvegicus	58-61
29879885-5	2018	Plasma norepinephrine (NE) and brain natriuretic peptide [BNP, termed B-type natriuretic peptide-45 (BNP-45) in rats] are regulated by sympathetic nerve activity.	Norepinephrine	7-21	natriuretic peptide B	Rattus norvegicus	101-104
28916252-3	2017	However, little is known about the role of MAO-A, an enzyme oxidizing 5-hydroxytryptamine and noradrenalin, in the pathogenesis.	Norepinephrine	94-106	monoamine oxidase A	Rattus norvegicus	43-48
29318546-3	2018	We here describe detailed methodology for the detection of pro- and active- forms of both MMP-2 (gelatinase A) and MMP-9 (gelatinase B) in cells using norepinephrine-stimulated H9c2 cardiomyoblasts as model.	Norepinephrine	151-165	matrix metallopeptidase 2	Homo sapiens	90-95
30068843-5	2018	We demonstrated that duloxetine, a serotonin and noradrenaline reuptake inhibitor, has an inhibitory effect on rat and human P2X4R.	Norepinephrine	49-62	purinergic receptor P2X 4	Homo sapiens	125-130
29029974-5	2017	In the acute phase of the arthritic process, decreased gene expression of MAO-A might lead to accumulation of noradrenaline in myocardial interstitial space, whereas increased gene expression of NET protected cardiomyocytes from the deleterious effects of enhanced noradrenaline.	Norepinephrine	110-123	monoamine oxidase A	Rattus norvegicus	74-79
28988768-5	2017	KCNK3 antagonizes norepinephrine-induced membrane depolarization by promoting potassium efflux in brown adipocytes.	Norepinephrine	18-32	potassium channel, subfamily K, member 3	Mus musculus	0-5
28646018-10	2017	Given the important role of alpha2AAR in controlling norepinephrine release and response, this novel regulation of alpha2AAR by APP may have an impact on modulation of noradrenergic activity and sympathetic tone.-Zhang, F., Gannon, M., Chen, Y., Zhou, L., Jiao, K., Wang, Q.	Norepinephrine	53-67	adenosine A2a receptor	Mus musculus	28-37
28646018-10	2017	Given the important role of alpha2AAR in controlling norepinephrine release and response, this novel regulation of alpha2AAR by APP may have an impact on modulation of noradrenergic activity and sympathetic tone.-Zhang, F., Gannon, M., Chen, Y., Zhou, L., Jiao, K., Wang, Q.	Norepinephrine	53-67	adenosine A2a receptor	Mus musculus	115-124
28887324-5	2017	Both epinephrine (EPI) and norepinephrine (NE) could directly inhibit breast cancer cell viability, as well as tumor growth in vivo EPI and NE activate the tumor suppressor Hippo signaling pathway, and the suppressive effect of exercise-conditioned serum was found to be mediated through phosphorylation and cytoplasmic retention of YAP and reduced expression of downstream target genes, for example, ANKRD1 and CTGF.	Norepinephrine	27-41	Yes1 associated transcriptional regulator	Homo sapiens	333-336
29163071-3	2017	Tyrosine hydroxylase (TH) immune-positive cells of the brainstem correspond to dopamine (DA)-, norepinephrine (NE)-, and epinephrine (E)-containing cells.	Norepinephrine	95-109	tyrosine hydroxylase	Mus musculus	0-20
28502584-6	2017	miR-325-3p blocked norepinephrine (NE) induced Aanat activation in cultured pinealocytes.	Norepinephrine	19-33	microRNA 325	Rattus norvegicus	0-7
28683170-3	2017	Treatment with noradrenaline (NA) stimulates GnIH release from diencephalic tissue blocks in vitro.	Norepinephrine	15-28	gonadotropin inhibitory hormone peptides	Coturnix japonica	45-49
28887324-5	2017	Both epinephrine (EPI) and norepinephrine (NE) could directly inhibit breast cancer cell viability, as well as tumor growth in vivo EPI and NE activate the tumor suppressor Hippo signaling pathway, and the suppressive effect of exercise-conditioned serum was found to be mediated through phosphorylation and cytoplasmic retention of YAP and reduced expression of downstream target genes, for example, ANKRD1 and CTGF.	Norepinephrine	27-41	cellular communication network factor 2	Homo sapiens	412-416
28953873-6	2017	Deletion of NLRP3 in ageing restored catecholamine-induced lipolysis by downregulating growth differentiation factor-3 (GDF3) and monoamine oxidase A (MAOA) that is known to degrade noradrenaline.	Norepinephrine	182-195	growth differentiation factor 3	Mus musculus	87-118
28530234-1	2017	Clandestine chemists synthesize novel stimulant drugs by exploiting structural templates known to target monoamine transporters for dopamine, norepinephrine, and serotonin (DAT, NET, and SERT, respectively).	Norepinephrine	142-156	solute carrier family 6 member 3	Rattus norvegicus	173-176
28953873-6	2017	Deletion of NLRP3 in ageing restored catecholamine-induced lipolysis by downregulating growth differentiation factor-3 (GDF3) and monoamine oxidase A (MAOA) that is known to degrade noradrenaline.	Norepinephrine	182-195	growth differentiation factor 3	Mus musculus	120-124
28476501-0	2017	Norepinephrine stimulation of alpha1D-adrenoceptor promotes proliferation of pulmonary artery smooth muscle cells via ERK-1/2 signaling.	Norepinephrine	0-14	adrenoceptor alpha 1D	Rattus norvegicus	30-50
28953873-6	2017	Deletion of NLRP3 in ageing restored catecholamine-induced lipolysis by downregulating growth differentiation factor-3 (GDF3) and monoamine oxidase A (MAOA) that is known to degrade noradrenaline.	Norepinephrine	182-195	monoamine oxidase A	Mus musculus	130-149
28476501-0	2017	Norepinephrine stimulation of alpha1D-adrenoceptor promotes proliferation of pulmonary artery smooth muscle cells via ERK-1/2 signaling.	Norepinephrine	0-14	mitogen activated protein kinase 3	Rattus norvegicus	118-125
28953873-6	2017	Deletion of NLRP3 in ageing restored catecholamine-induced lipolysis by downregulating growth differentiation factor-3 (GDF3) and monoamine oxidase A (MAOA) that is known to degrade noradrenaline.	Norepinephrine	182-195	monoamine oxidase A	Mus musculus	151-155
28953873-8	2017	Furthermore, inhibition of MAOA reversed the age-related reduction in noradrenaline concentration in adipose tissue, and restored lipolysis with increased levels of the key lipolytic enzymes adipose triglyceride lipase (ATGL) and hormone sensitive lipase (HSL).	Norepinephrine	70-83	monoamine oxidase A	Mus musculus	27-31
29472953-1	2017	Objective: Several studies have shown that some polymorphisms of genes encoding catechol-O-methyltransferase (COMT), the key enzyme in degrading dopamine, and norepinephrine and the human brain-derived neurotropic factor (BDNF), a nerve growth factor, are strong candidates for risk of schizophrenia (SCZ).	Norepinephrine	159-173	catechol-O-methyltransferase	Homo sapiens	80-108
28515684-9	2017	After the FST, CD157 KO mice showed decreases in striatal and hippocampal serotonin (5-HT) content, cortical norepinephrine (NE) content, and plasma corticosterone concentration.	Norepinephrine	109-123	bone marrow stromal cell antigen 1	Mus musculus	15-20
28502326-2	2017	Elevations in circulating epinephrine and norepinephrine unmask an interdependency that exists between K+ and Mg2+ based on their regulation of a large number of Mg2+-dependent Na+-K+-ATPase pumps present in skeletal muscle.	Norepinephrine	42-56	mucin 7, secreted	Homo sapiens	110-113
28502326-2	2017	Elevations in circulating epinephrine and norepinephrine unmask an interdependency that exists between K+ and Mg2+ based on their regulation of a large number of Mg2+-dependent Na+-K+-ATPase pumps present in skeletal muscle.	Norepinephrine	42-56	mucin 7, secreted	Homo sapiens	162-165
29472953-1	2017	Objective: Several studies have shown that some polymorphisms of genes encoding catechol-O-methyltransferase (COMT), the key enzyme in degrading dopamine, and norepinephrine and the human brain-derived neurotropic factor (BDNF), a nerve growth factor, are strong candidates for risk of schizophrenia (SCZ).	Norepinephrine	159-173	catechol-O-methyltransferase	Homo sapiens	110-114
28405802-4	2017	FABP4 alone had no influence on proliferation, migration, and inflammation of rat mesenteric arterial SMCs, while it significantly enhanced smooth muscle contraction and increases of systolic blood pressure (SBP) induced by noradrenaline (NA).	Norepinephrine	224-237	fatty acid binding protein 4	Rattus norvegicus	0-5
28698257-10	2017	Removal of TGF-beta or blocking its signaling before hypertension induction accelerated hypertension progression, whereas supplementation of TGF-beta1 substantially suppressed neuroinflammation, kidney norepinephrine level, and blood pressure.	Norepinephrine	202-216	transforming growth factor, beta 1	Mus musculus	141-150
28094445-0	2017	Presynaptic inhibition of transient receptor potential vanilloid type 1 (TRPV1) receptors by noradrenaline in nociceptive neurons.	Norepinephrine	93-106	transient receptor potential cation channel subfamily V member 1	Homo sapiens	26-71
28094445-0	2017	Presynaptic inhibition of transient receptor potential vanilloid type 1 (TRPV1) receptors by noradrenaline in nociceptive neurons.	Norepinephrine	93-106	transient receptor potential cation channel subfamily V member 1	Homo sapiens	73-78
28094445-2	2017	Noradrenaline strongly inhibited the activity of TRPV1 channels in dorsal root ganglia neurons.	Norepinephrine	0-13	transient receptor potential cation channel subfamily V member 1	Homo sapiens	49-54
28094445-4	2017	The inhibitory effect of noradrenaline on TRPV1 channels was dependent on calcium influx and linked to calcium/calmodulin-dependent protein kinase II.	Norepinephrine	25-38	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
28094445-4	2017	The inhibitory effect of noradrenaline on TRPV1 channels was dependent on calcium influx and linked to calcium/calmodulin-dependent protein kinase II.	Norepinephrine	25-38	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	103-149
28465228-7	2017	We also measured contents of monoamine neurotransmitters in the brains and found higher contents, especially of dopamine and noradrenaline, in the brains of Atp1a3-/- compared with those of Atp1a3+/+.	Norepinephrine	125-138	ATPase Na+/K+ transporting subunit alpha 3	Homo sapiens	157-163
28094445-6	2017	We suggest that modulation of presynaptic TRPV1 channels in nociceptive neurons by descending noradrenergic inputs may constitute a mechanism for noradrenaline to modulate incoming noxious stimuli in the dorsal horn of the spinal cord.	Norepinephrine	146-159	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
28094445-8	2017	To address whether noradrenaline can down-regulate TRPV1 channel activity in nociceptors and reduce their synaptic transmission, the effects of noradrenaline and clonidine were tested on the capsaicin-activated current recorded from acutely dissociated small diameter (&lt;27 mum) dorsal root ganglia (DRG) neurons and on miniature (m)EPSCs recorded from large lamina I neurons in horizontal spinal cord slices.	Norepinephrine	19-32	transient receptor potential cation channel subfamily V member 1	Homo sapiens	51-56
28094445-13	2017	In contrast, when the calcium/calmodulin-dependent protein kinase II (CaMKII) was blocked with KN-93, the inhibitory effect of noradrenaline on the capsaicin-activated current was greatly reduced, suggesting that activation of adrenergic receptors in DRG neurons is preferentially linked to CaMKII activity.	Norepinephrine	127-140	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	22-68
28094445-13	2017	In contrast, when the calcium/calmodulin-dependent protein kinase II (CaMKII) was blocked with KN-93, the inhibitory effect of noradrenaline on the capsaicin-activated current was greatly reduced, suggesting that activation of adrenergic receptors in DRG neurons is preferentially linked to CaMKII activity.	Norepinephrine	127-140	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	70-76
28094445-13	2017	In contrast, when the calcium/calmodulin-dependent protein kinase II (CaMKII) was blocked with KN-93, the inhibitory effect of noradrenaline on the capsaicin-activated current was greatly reduced, suggesting that activation of adrenergic receptors in DRG neurons is preferentially linked to CaMKII activity.	Norepinephrine	127-140	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	291-297
28094445-14	2017	We suggest that modulation of TRPV1 channels by noradrenaline in nociceptive neurons is a mechanism whereby noradrenaline may suppress incoming noxious stimuli at the primary synaptic afferents in the dorsal horn of the spinal cord.	Norepinephrine	48-61	transient receptor potential cation channel subfamily V member 1	Homo sapiens	30-35
28094445-14	2017	We suggest that modulation of TRPV1 channels by noradrenaline in nociceptive neurons is a mechanism whereby noradrenaline may suppress incoming noxious stimuli at the primary synaptic afferents in the dorsal horn of the spinal cord.	Norepinephrine	108-121	transient receptor potential cation channel subfamily V member 1	Homo sapiens	30-35
28522796-8	2017	We found that the Gly49-variant, the Gly389-variant, and the Val158-COMT-variant were associated with higher postoperative norepinephrine consumption.	Norepinephrine	123-137	catechol-O-methyltransferase	Homo sapiens	68-72
27753095-16	2017	Noradrenaline also evoked TRPC1 channel activity and associations between TRPC1, STIM1, Galphaq and PLCbeta1, which were inhibited by STIM1 knockdown.	Norepinephrine	0-13	phospholipase C beta 1	Homo sapiens	100-108
28522796-9	2017	All patients carrying the Val158-COMT allele exhibited higher preoperative norepinephrine concentrations.	Norepinephrine	75-89	catechol-O-methyltransferase	Homo sapiens	33-37
28522796-11	2017	CONCLUSIONS These data show that the beta1-adrenoceptor polymorphisms, together with the COMT polymorphism, affect norepinephrine consumption and stay in hospital in a situation of enhanced cardiovascular stress, reflected here by the postoperative period after cardiac surgery.	Norepinephrine	115-129	adrenoceptor beta 1	Homo sapiens	37-55
28522796-11	2017	CONCLUSIONS These data show that the beta1-adrenoceptor polymorphisms, together with the COMT polymorphism, affect norepinephrine consumption and stay in hospital in a situation of enhanced cardiovascular stress, reflected here by the postoperative period after cardiac surgery.	Norepinephrine	115-129	catechol-O-methyltransferase	Homo sapiens	89-93
28522796-12	2017	Moreover, we conclude that patients with the Val158-COMT genotype exhibit higher endogenous resting plasma norepinephrine levels.	Norepinephrine	107-121	catechol-O-methyltransferase	Homo sapiens	52-56
28008098-6	2017	BNP prevented the physiological decrease in cortisol during the late morning hours leading to elevated serum cortisol levels (P = 0.022) and increased circulating epinephrine and norepinephrine concentrations (P = 0.018 and P = 0.036, respectively).	Norepinephrine	179-193	natriuretic peptide B	Homo sapiens	0-3
28008098-10	2017	Here we report that intravenous administration of BNP in men leads to increases in adrenal hormones cortisol, epinephrine, and norepinephrine.	Norepinephrine	127-141	natriuretic peptide B	Homo sapiens	50-53
29552233-7	2017	OPN expression was increased in WT aortas from hypertensive mice (induced by either Ang II or norepinephrine).	Norepinephrine	94-108	secreted phosphoprotein 1	Mus musculus	0-3
27659446-1	2017	Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates corticosterone-sensitive uptake of monoamines including norepinephrine, epinephrine, dopamine, histamine and serotonin.	Norepinephrine	151-165	solute carrier family 22 member 3	Rattus norvegicus	0-28
27659446-1	2017	Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates corticosterone-sensitive uptake of monoamines including norepinephrine, epinephrine, dopamine, histamine and serotonin.	Norepinephrine	151-165	solute carrier family 22 member 3	Rattus norvegicus	30-34
27458023-1	2017	OBJECTIVES: The enzyme catechol-O-methyltransferase (COMT), which catalyses the degradation of dopamine and norepinephrine, is posited to participate in the pathophysiology of bipolar disorder (BD) and schizophrenia.	Norepinephrine	108-122	catechol-O-methyltransferase	Homo sapiens	23-51
27998005-0	2017	Sex differences in ischaemia/reperfusion-induced acute kidney injury depends on the degradation of noradrenaline by monoamine oxidase.	Norepinephrine	99-112	monoamine oxidase A	Rattus norvegicus	116-133
27998005-3	2017	In the present study, we used male and female Sprague-Dawley rats to investigate whether sex differences in the pathogenesis of ischaemic AKI are related to the degradation of NAd by monoamine oxidase (MAO) in the kidney.	Norepinephrine	176-179	monoamine oxidase A	Rattus norvegicus	183-200
27998005-3	2017	In the present study, we used male and female Sprague-Dawley rats to investigate whether sex differences in the pathogenesis of ischaemic AKI are related to the degradation of NAd by monoamine oxidase (MAO) in the kidney.	Norepinephrine	176-179	monoamine oxidase A	Rattus norvegicus	202-205
27458023-1	2017	OBJECTIVES: The enzyme catechol-O-methyltransferase (COMT), which catalyses the degradation of dopamine and norepinephrine, is posited to participate in the pathophysiology of bipolar disorder (BD) and schizophrenia.	Norepinephrine	108-122	catechol-O-methyltransferase	Homo sapiens	53-57
27997103-1	2017	Phenylethanolamine N-methyltransferase (PNMT) catalyzes the S-adenosyl-l-methionine (SAM)-dependent conversion of norepinephrine to epinephrine.	Norepinephrine	114-128	phenylethanolamine N-methyltransferase	Homo sapiens	0-38
27998005-8	2017	These results suggest that the degradation of NAd by MAOA in the kidney contributes to sex differences in the pathogenesis of ischaemia/reperfusion-induced AKI.	Norepinephrine	46-49	monoamine oxidase A	Rattus norvegicus	53-57
27923568-7	2017	Noradrenaline also increased CX3CL1 in its soluble form despite the inhibition of the activity and synthesis of ADAM10 and ADAM17, the main proteases known to cleave CX3CL1 from the neuronal membrane.	Norepinephrine	0-13	ADAM metallopeptidase domain 10	Homo sapiens	112-118
27951473-6	2017	In anaesthetized 7-week-old male Sprague-Dawley rats, the OA (3.8 mg of intravenous injection)-induced increase in plasma noradrenaline secretion was suppressed by TRPA1 or TRPV1 antagonist and by a beta2- or beta3-adrenoceptor antagonist.	Norepinephrine	122-135	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	173-178
27769854-6	2017	In mouse cortical slices, both L-AP4 and L-SOP were able to attenuate norepinephrine- and phenylephrine-stimulated PI hydrolysis at concentrations consistent with the activation of mGlu7 receptors.	Norepinephrine	70-84	transcription factor AP-4	Homo sapiens	33-36
27830577-6	2017	Orexin peptides excite other arousal-promoting neurons (noradrenaline, histamine, serotonin, acetylcholine neurons), either by activating mixed-cation conductances or by inhibiting potassium conductances.	Norepinephrine	56-69	hypocretin neuropeptide precursor	Homo sapiens	0-6
27940914-9	2016	Thus, one may speculate that a GAL3 antagonist could have antidepressant properties by disinhibiting the firing of these neurons, resulting in increased release of noradrenaline and serotonin in forebrain areas involved in mood regulation.	Norepinephrine	164-177	galectin 3	Homo sapiens	31-35
27647490-8	2016	Here, we show that mice lacking UCP3 (UCP3KO) have impaired sympathomimetic (methamphetamine) and completely abrogated lipopolysaccharide (LPS) thermogenesis, but a normal response to noradrenaline.	Norepinephrine	184-197	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	32-36
27647490-8	2016	Here, we show that mice lacking UCP3 (UCP3KO) have impaired sympathomimetic (methamphetamine) and completely abrogated lipopolysaccharide (LPS) thermogenesis, but a normal response to noradrenaline.	Norepinephrine	184-197	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	38-44
27647490-9	2016	By comparison, UCP1 knockout (UCP1KO) mice exhibit blunted methamphetamine and fully inhibited noradrenaline thermogenesis, but an increased febrile response to LPS.	Norepinephrine	95-108	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	15-19
27538721-10	2016	Kidney norepinephrine levels were markedly decreased at 8 weeks in RF-ABL vs. Sham-ABL SHR.	Norepinephrine	7-21	ABL proto-oncogene 1, non-receptor tyrosine kinase	Rattus norvegicus	70-73
27538721-10	2016	Kidney norepinephrine levels were markedly decreased at 8 weeks in RF-ABL vs. Sham-ABL SHR.	Norepinephrine	7-21	ABL proto-oncogene 1, non-receptor tyrosine kinase	Rattus norvegicus	83-86
27391165-1	2016	BACKGROUND AND PURPOSE: 4-Methyl-N-methylcathinone (mephedrone) is a synthetic stimulant that acts as a substrate-type releaser at transporters for dopamine (DAT), noradrenaline (NET) and 5-HT (SERT).	Norepinephrine	164-177	solute carrier family 6 member 3	Rattus norvegicus	158-161
27029212-6	2016	The dopamine and noradrenaline responses were suppressed by local infusion of a 5-HT1A receptor agonist, 7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol;hydrobromide, into the prefrontal cortex.	Norepinephrine	17-30	5-hydroxytryptamine receptor 1A	Rattus norvegicus	80-86
26959532-2	2016	By degrading norepinephrine and serotonin, the mitochondrial enzyme, monoamine oxidase-A (MAO-A), is a potent source of reactive oxygen species (ROS) in the heart and its activation leads to the persistence of mitochondrial damage.	Norepinephrine	13-27	monoamine oxidase A	Mus musculus	69-88
26959532-2	2016	By degrading norepinephrine and serotonin, the mitochondrial enzyme, monoamine oxidase-A (MAO-A), is a potent source of reactive oxygen species (ROS) in the heart and its activation leads to the persistence of mitochondrial damage.	Norepinephrine	13-27	monoamine oxidase A	Mus musculus	90-95
27301276-8	2016	RESULTS: Progesterone pretreatment decreased the contractile effect of (-)-noradrenaline through the alpha2-ARs.	Norepinephrine	71-88	adrenoceptor alpha 2A	Rattus norvegicus	101-111
27007161-4	2016	Expression of the enzyme, phenylethanolamine N-methyltransferase (PNMT), which catalyzes the methylation of norepinephrine to epinephrine, was significantly lower in malignant PCC/PGL as compared to benign samples.	Norepinephrine	108-122	phenylethanolamine N-methyltransferase	Homo sapiens	26-64
27007161-4	2016	Expression of the enzyme, phenylethanolamine N-methyltransferase (PNMT), which catalyzes the methylation of norepinephrine to epinephrine, was significantly lower in malignant PCC/PGL as compared to benign samples.	Norepinephrine	108-122	phenylethanolamine N-methyltransferase	Homo sapiens	66-70
27007161-4	2016	Expression of the enzyme, phenylethanolamine N-methyltransferase (PNMT), which catalyzes the methylation of norepinephrine to epinephrine, was significantly lower in malignant PCC/PGL as compared to benign samples.	Norepinephrine	108-122	crystallin gamma D	Homo sapiens	176-179
26562363-0	2016	Detecting a dexmedetomidine-evoked reduction of noradrenaline release in the human brain with the alpha2C-adrenoceptor PET ligand [11C]ORM-13070.	Norepinephrine	48-61	adrenoceptor alpha 2C	Homo sapiens	98-118
26562363-2	2016	The objective of this study was to test whether the receptor binding of the alpha2C -AR antagonist PET tracer [(11)C]ORM-13070 would increase in response to reductions in synaptic noradrenaline, evoked by dexmedetomidine as a sympatholytic drug challenge.	Norepinephrine	180-193	adrenoceptor alpha 2C	Homo sapiens	76-87
26459348-7	2015	Treatment of mice housed at 22 C with a beta2-adrenergic antagonist reverses the norepinephrine-driven suppression of GVHD and yields similar disease to mice housed at 30 C. Conversely, administering a beta2-adrenergic agonist decreases GVHD in mice housed at 30 C. In further mechanistic studies using beta2-adrenergic receptor-deficient (beta2-AR(-/-)) mice, we found that it is host cell beta2-AR signaling that is essential for decreasing GVHD.	Norepinephrine	81-95	histocompatibility 2, O region beta locus	Mus musculus	38-45
26603990-7	2015	OBP responders (office systolic BP reduction &gt;=10 mmHg) showed a greater reduction of the norepinephrine gradient compared to non-responders (-290+-450 pg/ml vs. -4+-106 pg/ml, p=0.01).	Norepinephrine	93-107	odorant binding protein 2A	Homo sapiens	0-3
26603990-8	2015	Patients with a reduction of norepinephrine gradient in both kidneys showed the most pronounced decrease of the systolic OBP (-24+-14 mmHg) compared to patients with a reduction of norepinephrine gradient in only one kidney (-7+-15 mmHg) or patients without a norepinephrine reduction (-3+-19 mmHg, p=0.03 vs. bilateral reduction).	Norepinephrine	29-43	odorant binding protein 2A	Homo sapiens	121-124
26277325-0	2015	Reduction in renal blood flow following administration of norepinephrine and phenylephrine in septic rats treated with Kir6.1 ATP-sensitive and KCa1.1 calcium-activated K+ channel blockers.	Norepinephrine	58-72	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	144-150
26209056-11	2015	In a multiple-regression analysis, norepinephrine (beta = 2.67, P = 0.0004) and age (beta = -0.061, P = 0.022) were associated with 1-min Pmsf.	Norepinephrine	35-49	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	51-59
26346727-4	2015	COMT has an important role in regulating the embryonic levels of catecholamine neurotransmitters (such as dopamine, norepinephrine, and epinephrine) and estrogens.	Norepinephrine	116-130	catechol-O-methyltransferase	Homo sapiens	0-4
26058426-6	2015	Mice treated with norepinephrine, displayed an increased number of metastatic foci of DU145 cells in inguinal lymph nodes and also showed an increased expression of MMP2 and MMP9 in tumor samples compared to controls.	Norepinephrine	18-32	matrix metallopeptidase 2	Homo sapiens	165-169
25869507-7	2015	The combined treatment reversed the hyporeactivity to nor-adrenaline through preservation of alpha1D AR mRNA/protein expression and reversal of alpha1D AR desensitization mediated by GRK2/Gbetagamma pathway.	Norepinephrine	54-68	adrenergic receptor, alpha 1d	Mus musculus	93-103
25869507-7	2015	The combined treatment reversed the hyporeactivity to nor-adrenaline through preservation of alpha1D AR mRNA/protein expression and reversal of alpha1D AR desensitization mediated by GRK2/Gbetagamma pathway.	Norepinephrine	54-68	adrenergic receptor, alpha 1d	Mus musculus	144-154
26219508-7	2015	MSCs from experimental condylar subchondral bone expressed higher levels of beta2-AR and RANKL; norepinephrine stimulation further increased their RANKL expression and pro-osteoclastic function.	Norepinephrine	96-110	TNF superfamily member 11	Rattus norvegicus	147-152
25924103-4	2015	We administered FGF21 into the central nervous system via lateral ventricle infusion into male mice and found that the central treatment increased norepinephrine turnover in target tissues that include the inguinal white adipose tissue and brown adipose tissue.	Norepinephrine	147-161	fibroblast growth factor 21	Mus musculus	16-21
25738783-5	2015	Surprisingly, we found that mice lacking uncoupling protein 1 (UCP1) have fully preserved BAT blood flow response to norepinephrine despite failing to perform thermogenesis.	Norepinephrine	117-131	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	41-61
25738783-5	2015	Surprisingly, we found that mice lacking uncoupling protein 1 (UCP1) have fully preserved BAT blood flow response to norepinephrine despite failing to perform thermogenesis.	Norepinephrine	117-131	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	63-67
25572945-9	2015	GDNF increased the noradrenaline content in the dorsal spinal cord.	Norepinephrine	19-32	glial cell derived neurotrophic factor	Rattus norvegicus	0-4
26504670-2	2015	New evidence show that the stress hormone noradrenaline enhances melanoma microenvironment reactivity, mainly acting through beta3-adrenoreceptors (beta2-ARs), favoring recruitment of cancer-associated fibroblasts, M2-macrophages, bone marrow-derived precursors, These events concur in sustaining a pro-inflammatory and pro-angiogenic milieu, finally boosting melanoma malignancy.	Norepinephrine	42-55	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	148-153
25440572-9	2015	The isometric contraction study revealed that both nifedipine (Cav 1.2 channel blocker) and NS11021 (KCa 1.1 channel activator) induced concentration-dependent vasorelaxation in MAs precontracted with noradrenaline.	Norepinephrine	201-214	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	101-108
25799564-9	2015	It was observed that when alpha1B-adrenergic receptors were stimulated with noradrenaline, the receptors interacted with proteins present in early endosomes, such as the early endosomes antigen 1, Rab 5, Rab 4, and Rab 11 but not with late endosome markers, such as Rab 9 and Rab 7.	Norepinephrine	76-89	RAB7B, member RAS oncogene family	Homo sapiens	276-281
25789868-11	2015	RESULTS: Adrenaline and noradrenaline correlated positively with syndecan-1 and thrombomodulin i.e., biomarkers reflecting endothelial damage (both p&lt;0.05).	Norepinephrine	24-37	syndecan 1	Homo sapiens	65-75
25562714-5	2015	Furthermore, to clarify the role of angiotensin II type 2 receptors (AT2) in norepinephrine (NE) release and the blood pressure of rat model of stress-induced hypertension, we intraperitoneally administered the AT2 receptor antagonist PD123319 (AT2 receptor antagonist, 0.3mg/kg, i.p.)	Norepinephrine	77-91	angiotensin II receptor, type 2	Rattus norvegicus	69-72
25437118-7	2015	In vitro, norepinephrine up-regulated expression of VEGF and IL-8 in sunitinib-treated cancer cells mainly through the beta-adrenoceptor-cAMP-PKA signaling pathway.	Norepinephrine	10-24	chemokine (C-X-C motif) ligand 15	Mus musculus	61-65
25451930-4	2015	Despite its hyperfunctionality, we found the Arg-389 variant of ADRB1 to be hyperphosphorylated upon continuous stimulation with norepinephrine compared with the Gly-389 variant.	Norepinephrine	129-143	adrenoceptor beta 1	Homo sapiens	64-69
25368027-6	2015	Because DPP4 inhibitors impair the metabolism of neuropeptide Y1-36 (NPY1-36; Y1-receptor agonist) and glucagon-like peptide (GLP)-1(7-36)NH2 (GLP-1 receptor agonist), we examined renovascular responses to NPY1-36 and GLP-1(7-36)NH2 in isolated perfused SHR and Zucker Diabetic-Sprague Dawley kidneys pretreated with norepinephrine (to induce basal tone).	Norepinephrine	317-331	dipeptidylpeptidase 4	Rattus norvegicus	8-12
25557223-5	2015	The visceral and noradrenaline, unlike dopamine, responses were blocked by a CRF1 antagonist injected into the CeA.	Norepinephrine	17-30	corticotropin releasing hormone receptor 1	Homo sapiens	77-81
25522417-3	2014	METHODS: We explored the use of the novel alpha2C-adrenoceptor antagonist PET tracer [(11)C]ORM-13070 for measurement of amphetamine-induced changes in synaptic norepinephrine.	Norepinephrine	161-175	adrenoceptor alpha 2C	Rattus norvegicus	42-62
25242119-9	2014	This implicates the spinal alpha2A-adrenoceptor subtype in the action of ultra-low dose alpha2-adrenoceptor antagonists on morphine and norepinephrine tolerance.	Norepinephrine	136-150	adrenoceptor alpha 2A	Rattus norvegicus	27-47
25242632-1	2014	Reduced levels of noradrenaline (NA) in CNS of multiple sclerosis patients could be due to metabolism by catechol-O-methyltransferase (COMT).	Norepinephrine	18-31	catechol-O-methyltransferase	Homo sapiens	105-133
25242632-1	2014	Reduced levels of noradrenaline (NA) in CNS of multiple sclerosis patients could be due to metabolism by catechol-O-methyltransferase (COMT).	Norepinephrine	18-31	catechol-O-methyltransferase	Homo sapiens	135-139
25056351-12	2014	Both FAK inhibitors PF-573228 and Y-11 significantly inhibited norepinephrine- and phenylephrine-induced contractions.	Norepinephrine	63-77	protein tyrosine kinase 2	Homo sapiens	5-8
25149991-7	2014	CONCLUSIONS: LKP lowered MAP in norepinephrine-induced hypertension, probably via activation of AT2R.	Norepinephrine	32-46	angiotensin II receptor, type 2	Rattus norvegicus	96-100
25187989-2	2014	In the current study we demonstrate that the noradrenalin analogue octopamine and the cholecystokinin (CCK) homologue Drosulfakinin (Dsk) function downstream of TfAP-2 and Tiwaz (Twz) to control the number of meals in adult flies.	Norepinephrine	45-57	tiwaz	Drosophila melanogaster	179-182
25071172-7	2014	Central PREP regulation of insulin and glucagon secretion appears to be mediated by the autonomic nervous system because Prep(gt/gt) mice have elevated sympathetic outflow and norepinephrine levels in the pancreas, and propranolol treatment reversed glucose intolerance in these mice.	Norepinephrine	176-190	prolyl endopeptidase	Mus musculus	8-12
25071172-7	2014	Central PREP regulation of insulin and glucagon secretion appears to be mediated by the autonomic nervous system because Prep(gt/gt) mice have elevated sympathetic outflow and norepinephrine levels in the pancreas, and propranolol treatment reversed glucose intolerance in these mice.	Norepinephrine	176-190	prolyl endopeptidase	Mus musculus	121-125
25353000-4	2014	In both DIO and RYGB settings, these changes in ghrelin levels were associated with altered ghrelin cell responsiveness to two key physiological modulators of ghrelin secretion - glucose and norepinephrine.	Norepinephrine	191-205	ghrelin	Mus musculus	48-55
25353000-4	2014	In both DIO and RYGB settings, these changes in ghrelin levels were associated with altered ghrelin cell responsiveness to two key physiological modulators of ghrelin secretion - glucose and norepinephrine.	Norepinephrine	191-205	ghrelin	Mus musculus	92-99
25353000-4	2014	In both DIO and RYGB settings, these changes in ghrelin levels were associated with altered ghrelin cell responsiveness to two key physiological modulators of ghrelin secretion - glucose and norepinephrine.	Norepinephrine	191-205	ghrelin	Mus musculus	92-99
24837703-10	2014	Considering greater affinity of arterenol for alpha1-ARs than for beta2-ARs, the previous findings could be attributable to increased engagement of beta2-ARs with the rise of arterenol concentration.	Norepinephrine	32-41	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	148-153
24837703-10	2014	Considering greater affinity of arterenol for alpha1-ARs than for beta2-ARs, the previous findings could be attributable to increased engagement of beta2-ARs with the rise of arterenol concentration.	Norepinephrine	175-184	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	148-153
24668024-6	2014	The effects of (-)-noradrenaline, mediated through beta1-adrenoceptors (beta2-adrenoceptors blocked with ICI118551), and (-)-adrenaline, mediated through beta2-adrenoceptors (beta1-adrenoceptors blocked with CGP20712A), were assessed in the absence and presence of the PDE inhibitors.	Norepinephrine	15-32	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	72-77
24952646-8	2014	Under conditions of chronic variable stress in mice, sympathetic nerve fibers released surplus noradrenaline, which signaled bone marrow niche cells to decrease CXCL12 levels through the beta3-adrenergic receptor.	Norepinephrine	95-108	chemokine (C-X-C motif) ligand 12	Mus musculus	161-167
24657150-8	2014	Intracerebroventricularly administered PGE2 (0.3 and 1.5 nmol/animal) and sulprostone (0.1 and 0.3 nmol/animal) (EP1/EP3 agonist) also elevated plasma noradrenaline but not adrenaline in a dose-dependent manner.	Norepinephrine	151-164	prostaglandin E receptor 1	Rattus norvegicus	113-120
24888351-2	2014	Activation of the insulin receptor stimulates VSMCs proliferation while dopamine receptors, via D1 and D3 receptors, inhibit the stimulatory effects of norepinephrine on VSMCs proliferation.	Norepinephrine	152-166	insulin receptor	Rattus norvegicus	18-34
24887309-13	2014	Critical illness severity (assessed by Acute Physiology and Chronic Health Evaluation II and maximum Sequential Organ Failure Assessment scores), and peak noradrenaline dose on day 1 were independent determinants of BNP elevation (P &lt;0.05).	Norepinephrine	155-168	natriuretic peptide B	Homo sapiens	216-219
24663151-1	2014	The beta1-adrenoceptor (beta1AR) is a G protein-coupled receptor (GPCR) that is activated by the endogenous agonists adrenaline and noradrenaline.	Norepinephrine	132-145	adrenoceptor beta 1	Homo sapiens	4-22
24663151-1	2014	The beta1-adrenoceptor (beta1AR) is a G protein-coupled receptor (GPCR) that is activated by the endogenous agonists adrenaline and noradrenaline.	Norepinephrine	132-145	adrenoceptor beta 1	Homo sapiens	24-31
24431221-3	2014	The sympathetic neurotransmitter Norepinephrine (NE) induced complete and rapid mitochondrial fragmentation in BA, characterized by Drp1 phosphorylation and Opa1 cleavage.	Norepinephrine	33-47	death-associated protein kinase 2	Mus musculus	132-136
23508458-9	2014	RESULTS: In the adrenals of AA (-) SMP30/GNL KO mice, noradrenaline and adrenaline levels decreased significantly compared to other three groups of mice, although there were no significant differences in dopamine beta-hydroxylase or phenylethanolamine N-methyltransferase mRNA content.	Norepinephrine	54-67	regucalcin	Mus musculus	41-44
24222669-9	2014	Furthermore, pretreatment with GW-9508 blocked the effect of the norepinephrine (NE)-induced ghrelin elevation in ghrelin cell lines.	Norepinephrine	65-79	ghrelin	Mus musculus	93-100
24222669-9	2014	Furthermore, pretreatment with GW-9508 blocked the effect of the norepinephrine (NE)-induced ghrelin elevation in ghrelin cell lines.	Norepinephrine	65-79	ghrelin	Mus musculus	114-121
23985701-0	2014	Inhibition of farnesyl pyrophosphate synthase prevents norepinephrine-induced fibrotic responses in vascular smooth muscle cells from spontaneously hypertensive rats.	Norepinephrine	55-69	farnesyl diphosphate synthase	Rattus norvegicus	14-45
24642449-5	2014	However, the copresence of LPS and either epinephrine or norepinephrine resulted in a strong M2 phenotype including high levels of arginase-1 and interleukin-10, and a reduced expression of M1 markers.	Norepinephrine	57-71	arginase, liver	Mus musculus	131-141
24095796-3	2013	METHODS AND RESULTS: In embryos lacking the sodium-dependent vitamin C transporter 2 (SVCT2), very low levels of brain ascorbate decreased cortex levels of norepinephrine and dopamine by approximately 33%, but had no effect on cortex serotonin or its metabolite, 5-hydroxyindole acetic acid.	Norepinephrine	156-170	solute carrier family 23 (nucleobase transporters), member 2	Mus musculus	86-91
24018397-1	2013	Phenylethanolamine N-methyltransferase (PNMT) catalyzes the conversion of norepinephrine (noradrenaline) to epinephrine (adrenaline) while, concomitantly, S-adenosyl-L-methionine (AdoMet) is converted to S-adenosyl-L-homocysteine.	Norepinephrine	74-88	phenylethanolamine N-methyltransferase	Homo sapiens	0-38
24018397-1	2013	Phenylethanolamine N-methyltransferase (PNMT) catalyzes the conversion of norepinephrine (noradrenaline) to epinephrine (adrenaline) while, concomitantly, S-adenosyl-L-methionine (AdoMet) is converted to S-adenosyl-L-homocysteine.	Norepinephrine	74-88	phenylethanolamine N-methyltransferase	Homo sapiens	40-44
24018397-1	2013	Phenylethanolamine N-methyltransferase (PNMT) catalyzes the conversion of norepinephrine (noradrenaline) to epinephrine (adrenaline) while, concomitantly, S-adenosyl-L-methionine (AdoMet) is converted to S-adenosyl-L-homocysteine.	Norepinephrine	90-103	phenylethanolamine N-methyltransferase	Homo sapiens	0-38
24018397-1	2013	Phenylethanolamine N-methyltransferase (PNMT) catalyzes the conversion of norepinephrine (noradrenaline) to epinephrine (adrenaline) while, concomitantly, S-adenosyl-L-methionine (AdoMet) is converted to S-adenosyl-L-homocysteine.	Norepinephrine	90-103	phenylethanolamine N-methyltransferase	Homo sapiens	40-44
24018397-3	2013	At various times the kinetic mechanism of PNMT has been reported to operate by a random mechanism, an ordered mechanism in which norepinephrine binds first, and an ordered mechanism in which AdoMet binds first.	Norepinephrine	129-143	phenylethanolamine N-methyltransferase	Homo sapiens	42-46
23993195-8	2013	Electrophysiological analysis showed that Galphao-mediated inhibition of calcium currents by norepinephrine tended to be lower in three of the four Galphao mutants.	Norepinephrine	93-107	G protein subunit alpha o1	Homo sapiens	42-49
23993195-8	2013	Electrophysiological analysis showed that Galphao-mediated inhibition of calcium currents by norepinephrine tended to be lower in three of the four Galphao mutants.	Norepinephrine	93-107	G protein subunit alpha o1	Homo sapiens	148-155
23714242-0	2013	CGRP inhibits norepinephrine induced apoptosis with restoration of Bcl-2/Bax in cultured cardiomyocytes of rat.	Norepinephrine	14-28	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
23530669-5	2013	This action may result from its inhibitory neuromodulatory action on NE [noradrenaline (norepinephrine)] levels at the synaptic cleft, i.e. Ang-(1-7) reduces NE release and synthesis, whereas it causes an increase in NE transporter expression, contributing in this way to central NE neuromodulation.	Norepinephrine	73-86	angiopoietin 1	Homo sapiens	140-148
23530669-5	2013	This action may result from its inhibitory neuromodulatory action on NE [noradrenaline (norepinephrine)] levels at the synaptic cleft, i.e. Ang-(1-7) reduces NE release and synthesis, whereas it causes an increase in NE transporter expression, contributing in this way to central NE neuromodulation.	Norepinephrine	88-102	angiopoietin 1	Homo sapiens	140-148
22382522-0	2013	Berberine inhibits norepinephrine-induced apoptosis in neonatal rat cardiomyocytes via inhibiting ROS-TNF-alpha-caspase signaling pathway.	Norepinephrine	19-33	caspase 2	Rattus norvegicus	112-119
23742775-17	2013	Norepinephrine significantly increased ROCK-1 activity in cirrhotic rats when GRK-2 inhibitor was used.	Norepinephrine	0-14	G protein-coupled receptor kinase 2	Rattus norvegicus	78-83
23523917-4	2013	Here, we found that the abundance of regulator of G-protein signaling 2 (RGS2) increases at night, that expression is increased by norepinephrine and that this protein has a negative feedback effect on melatonin production.	Norepinephrine	131-145	regulator of G protein signaling 2	Homo sapiens	37-71
23523917-4	2013	Here, we found that the abundance of regulator of G-protein signaling 2 (RGS2) increases at night, that expression is increased by norepinephrine and that this protein has a negative feedback effect on melatonin production.	Norepinephrine	131-145	regulator of G protein signaling 2	Homo sapiens	73-77
23515286-8	2013	Metoprolol treatment and ghrelin treatment in KO mice prevented excessive sympathetic activation, decreased plasma epinephrine and norepinephrine levels, and improved heart function and survival rate after MI.	Norepinephrine	131-145	ghrelin	Mus musculus	25-32
23573890-4	2013	The data provided in the present study, demonstrate the novel ultrastructural immunolocalization of both CgA and VMAT2 in protein bodies, supporting their involvement in somatodendritic storage and release of noradrenaline in human LC.	Norepinephrine	209-222	solute carrier family 18 member A2	Homo sapiens	113-118
23307791-14	2013	Finally, co-incubation with the sympathetic neurotransmitter norepinephrine potentiated the glucagon stimulation of ghrelin secretion.	Norepinephrine	61-75	ghrelin and obestatin prepropeptide	Rattus norvegicus	116-123
23307791-15	2013	Our findings are the first to show a direct link between glucagon and stomach ghrelin production and secretion and highlight the role of MAPK, the PKA-independent EPAC pathway, and the synergy between norepinephrine and glucagon in ghrelin release.	Norepinephrine	201-215	ghrelin and obestatin prepropeptide	Rattus norvegicus	78-85
23280413-1	2013	Catechol-O-methyltransferase (COMT) catalyzes the methylation of catecholamines, including neurotransmitters like dopamine, epinephrine and norepinephrine, leading to their degradation.	Norepinephrine	140-154	catechol-O-methyltransferase	Homo sapiens	0-28
23280413-1	2013	Catechol-O-methyltransferase (COMT) catalyzes the methylation of catecholamines, including neurotransmitters like dopamine, epinephrine and norepinephrine, leading to their degradation.	Norepinephrine	140-154	catechol-O-methyltransferase	Homo sapiens	30-34
23565492-1	2012	Neuropeptide Y (NPY) is a neuropeptide widely expressed in the brain and a peptide transmitter of sympathetic nervous system (SNS) co-released with noradrenaline (NA) in prolonged stress.	Norepinephrine	148-161	neuropeptide Y	Mus musculus	0-14
23565492-1	2012	Neuropeptide Y (NPY) is a neuropeptide widely expressed in the brain and a peptide transmitter of sympathetic nervous system (SNS) co-released with noradrenaline (NA) in prolonged stress.	Norepinephrine	148-161	neuropeptide Y	Mus musculus	16-19
22971542-1	2012	Monoamine oxidase A (MAO-A) is the key enzyme for the degradation of brain serotonin (5-hydroxytryptamine, 5-HT), norepinephrine (NE) and dopamine (DA).	Norepinephrine	114-128	monoamine oxidase A	Mus musculus	0-19
22971542-1	2012	Monoamine oxidase A (MAO-A) is the key enzyme for the degradation of brain serotonin (5-hydroxytryptamine, 5-HT), norepinephrine (NE) and dopamine (DA).	Norepinephrine	114-128	monoamine oxidase A	Mus musculus	21-26
24900562-1	2013	Herein, we describe the discovery of inhibitors of norepinephrine (NET) and dopamine (DAT) transporters with reduced activity relative to serotonin transporters (SERT).	Norepinephrine	51-65	solute carrier family 6 member 3	Rattus norvegicus	86-89
22513004-6	2012	Functional studies, conducted primarily on lipocalin 2 (Lcn2), the mouse homologue of human NGAL have revealed that Lcn2 has a strong affinity for iron complexed to both bacterial siderophores (iron-binding proteins) and certain human proteins like norepinephrine.	Norepinephrine	249-263	lipocalin 2	Mus musculus	43-54
22513004-6	2012	Functional studies, conducted primarily on lipocalin 2 (Lcn2), the mouse homologue of human NGAL have revealed that Lcn2 has a strong affinity for iron complexed to both bacterial siderophores (iron-binding proteins) and certain human proteins like norepinephrine.	Norepinephrine	249-263	lipocalin 2	Mus musculus	56-60
22510725-2	2012	The neuropeptide, corticotropin-releasing factor (CRF), coordinates the physiological and behavioral responses to stress, in part, by activating the locus coeruleus-norepinephrine (LC-NE) projection system.	Norepinephrine	165-179	pyroglutamylated RFamide peptide	Rattus norvegicus	4-16
22988760-2	2012	Calmodulin inhibitors trifluoperazine and W-13 suppress vasoconstriction of the rat aorta in response to norepinephrine, serotonin, and serotonin 5HT1A- and 5HT2A-receptor agonists (8-OH-DPAT and DOI, respectively) and do not affect the vasodilatory effect of 5HT1B-, 5HT2B-, and 5HT4-receptors.	Norepinephrine	105-119	calmodulin 1	Rattus norvegicus	0-10
22988760-5	2012	The inhibitor of calmodulin-dependent myosin light chain kinase KN93 decreases the vasoconstrictive response in response to norepinephrine and serotonin by only 20%.	Norepinephrine	124-138	calmodulin 1	Rattus norvegicus	17-27
22465165-5	2012	Twenty min after leptin treatment, there were higher plasma concentrations of noradrenaline, but not adrenaline, in comparison with the saline-treated control group.	Norepinephrine	78-91	leptin	Rattus norvegicus	17-23
21932058-2	2012	The study was tested in a fecal peritonitis-induced septic shock model, we observed that levosimendan combined with arginine vasopressin supplemented with norepinephrine therapy resulted in lower mean pulmonary artery pressure, lactate concentrations, arterial total nitrate/nitrite, and high-mobility group box 1 levels; decreased lung wet/dry ratio, and pulmonary levels of interleukin-6, total histological scores, and improved pulmonary gas exchange when compared with norepinephrine group.	Norepinephrine	155-169	high mobility group box 1	Homo sapiens	288-313
22624173-3	2004	Vesicular monoamine transporter (VMAT2) is present in brain monoaminergic neurons and is responsible for collecting neurotransmitters (e.g., dopamine, norepinephrine, and serotonin) from the cytoplasm and storing them in vesicles for synaptic release (1).	Norepinephrine	151-165	solute carrier family 18 member A2	Homo sapiens	33-38
22624175-3	2004	Vesicular monoamine transporter (VMAT2) is present in brain monoaminergic neurons and is responsible for collecting neurotransmitters (e.g., dopamine, norepinephrine, and serotonin) from the cytoplasm and storing them in vesicles for synaptic release (1).	Norepinephrine	151-165	solute carrier family 18 member A2	Homo sapiens	33-38
22538810-1	2012	Parathyroid hormone (PTH), the major calcium-regulating hormone, and norepinephrine (NE), the principal neurotransmitter of sympathetic nerves, regulate bone remodeling by activating distinct cell-surface G protein-coupled receptors in osteoblasts: the parathyroid hormone type 1 receptor (PTHR) and the beta(2)-adrenergic receptor (beta(2)AR), respectively.	Norepinephrine	69-83	parathyroid hormone	Mus musculus	253-272
22371491-3	2012	By utilizing the G protein-coupled receptor (GPCR) heteromer identification technology on the live cell-based bioluminescence resonance energy transfer (BRET) assay platform, our studies in human embryonic kidney 293 cells have identified norepinephrine-dependent beta-arrestin recruitment that was in turn dependent upon co-expression of alpha(1A)AR with CXCR2.	Norepinephrine	239-253	C-X-C motif chemokine receptor 2	Homo sapiens	356-361
22371491-5	2012	This norepinephrine-dependent beta-arrestin recruitment was inhibited not only by the alpha(1)AR antagonist Terazosin but also by the CXCR2-specific allosteric inverse agonist SB265610.	Norepinephrine	5-19	C-X-C motif chemokine receptor 2	Homo sapiens	134-139
22371619-7	2012	The effect of the gene polymorphism of catechol-O-methyltransferase (COMT) on individual variations in switching frequency suggests that the balance of exploration and stabilization is modulated by catecholamines such as dopamine and noradrenalin.	Norepinephrine	234-246	catechol-O-methyltransferase	Homo sapiens	39-67
22371619-7	2012	The effect of the gene polymorphism of catechol-O-methyltransferase (COMT) on individual variations in switching frequency suggests that the balance of exploration and stabilization is modulated by catecholamines such as dopamine and noradrenalin.	Norepinephrine	234-246	catechol-O-methyltransferase	Homo sapiens	69-73
22040172-2	2012	The presynaptic alpha(2C)-adrenoceptor inhibits the release of norepinephrine from sympathetic nerve terminals in the heart.	Norepinephrine	63-77	adrenoceptor alpha 2C	Homo sapiens	16-38
22212880-4	2012	Administration of hydrocortisone or dexamethasone to female rats on day 20 of pregnancy significantly increased TH mRNA levels (real-time PCR) and enzyme activity (DOPA accumulation after inhibition of aromatic L: -amino acid decarboxylase with NSD-1015) as well as noradrenaline concentrations in the brainstem of fetuses 6 h after the treatment.	Norepinephrine	266-279	tyrosine hydroxylase	Rattus norvegicus	112-114
22253419-7	2012	The induction of RBP4 gene expression by norepinephrine required intact PPAR-dependent pathways, as evidenced by impaired response of the RBP4 gene expression to norepinephrine in PPARalpha-null brown adipocytes or in the presence of inhibitors of PPARgamma and PPARalpha.	Norepinephrine	41-55	peroxisome proliferator activated receptor gamma	Mus musculus	248-257
22253419-11	2012	The induction of the RBP4 gene expression by norepinephrine in brown adipocytes is protein synthesis dependent and requires PPARgamma-coactivator-1-alpha, which acts as a norepinephine-induced coactivator of PPAR on the RBP4 gene.	Norepinephrine	45-59	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	124-153
22149309-3	2012	The alpha(1D)-adrenoceptor antagonist, BMY-7378 (BMY) blocked noradrenaline-induced responses in the order SO &gt; AC7 &gt;&gt; AC14; in contrast, the alpha(1A)-adrenoceptor antagonist RS-100329 (RS), produced a marginal shift to the right of the dose-response curve to noradrenaline, along with a strong decrease of the maximum pressor effect in the order SO &gt; AC7 = AC14.	Norepinephrine	62-75	adrenoceptor alpha 1D	Rattus norvegicus	4-26
22011436-2	2012	Conversely, angiotensin II, formed locally by mast cell-derived renin, stimulates NHE via angiotensin II type 1 (AT1) receptors, facilitating norepinephrine release and arrhythmias.	Norepinephrine	142-156	angiotensin II receptor, type 1a	Rattus norvegicus	113-116
23160220-6	2012	RESULTS: CD4+ T lymphocytes with TH RNAi expressed less TH mRNA and protein and synthesized less CAs including norepinephrine, epinephrine and dopamine than control cells with mock transfection.	Norepinephrine	111-125	tyrosine hydroxylase	Mus musculus	33-35
23227251-0	2012	Antidepressant acts on astrocytes leading to an increase in the expression of neurotrophic/growth factors: differential regulation of FGF-2 by noradrenaline.	Norepinephrine	143-156	fibroblast growth factor 2	Rattus norvegicus	134-139
23227251-7	2012	Noradrenaline (NA) is known to induce FGF-2 expression in astrocyte cultures, as with antidepressants.	Norepinephrine	0-13	fibroblast growth factor 2	Rattus norvegicus	38-43
22655045-6	2012	SgII was produced in several cell types in the myocardium and cardiomyocyte synthesis of SgII was potently induced by transforming growth factor-beta and norepinephrine stimulation in vitro.	Norepinephrine	154-168	secretogranin II	Homo sapiens	0-4
22655045-6	2012	SgII was produced in several cell types in the myocardium and cardiomyocyte synthesis of SgII was potently induced by transforming growth factor-beta and norepinephrine stimulation in vitro.	Norepinephrine	154-168	secretogranin II	Homo sapiens	89-93
21832987-1	2011	Monoamine oxidase (MAO)-A is a key enzyme for the degradation of brain serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE).	Norepinephrine	113-127	monoamine oxidase A	Mus musculus	0-25
22101429-3	2011	Acting via the beta(3)-adrenergic receptors, noradrenaline induces lipolysis in white adipocytes, whereas it stimulates the expression of thermogenic genes, such as PPAR-gamma coactivator 1a (Ppargc1a), uncoupling protein 1 (Ucp1) and acyl-CoA synthetase long-chain family member 1 (Acsl1), in brown adipocytes.	Norepinephrine	45-58	acyl-CoA synthetase long chain family member 1	Homo sapiens	235-281
22101429-3	2011	Acting via the beta(3)-adrenergic receptors, noradrenaline induces lipolysis in white adipocytes, whereas it stimulates the expression of thermogenic genes, such as PPAR-gamma coactivator 1a (Ppargc1a), uncoupling protein 1 (Ucp1) and acyl-CoA synthetase long-chain family member 1 (Acsl1), in brown adipocytes.	Norepinephrine	45-58	acyl-CoA synthetase long chain family member 1	Homo sapiens	283-288
21598299-2	2011	We have shown that, in isolated artery stimulated with noradrenaline, EBP50 interacts with several elements of the cytoskeleton.	Norepinephrine	55-68	SLC9A3 regulator 1	Homo sapiens	70-75
21414668-1	2011	The catechol-O-methyltransferase (COMT) gene is a candidate gene for schizophrenia as its encoded enzyme is involved in the metabolic inactivation of dopamine and noradrenaline.	Norepinephrine	163-176	catechol-O-methyltransferase	Homo sapiens	4-32
21414668-1	2011	The catechol-O-methyltransferase (COMT) gene is a candidate gene for schizophrenia as its encoded enzyme is involved in the metabolic inactivation of dopamine and noradrenaline.	Norepinephrine	163-176	catechol-O-methyltransferase	Homo sapiens	34-38
21521766-5	2011	Presynaptic injection of NT or AID peptide into SCGN synapses inhibited synaptic transmission and also attenuated noradrenaline-induced G protein modulation.	Norepinephrine	114-127	activation induced cytidine deaminase	Homo sapiens	31-34
21521766-6	2011	In isolated SCGNs, NT and AID peptides reduced whole-cell Ca2+ current amplitude, modified voltage dependence of Ca2+ channel activation and attenuated noradrenaline-induced G protein modulation.	Norepinephrine	152-165	activation induced cytidine deaminase	Homo sapiens	26-29
21199648-7	2011	The salt-sensitive hypertension in rodents with impaired gamma-MSH signaling appears due to stimulation of noradrenergic activity, since plasma noradrenaline is increased and the hypertension is rapidly corrected with infusion of the alpha-adrenoceptor antagonist phentolamine.	Norepinephrine	144-157	pro-opiomelanocortin-alpha	Mus musculus	57-66
26610136-3	2011	PNMT catalyzes the conversion of norepinephrine into epinephrine (adrenaline), and inhibitors of PNMT are of potential therapeutic importance in Alzheimer"s and Parkinson"s disease.	Norepinephrine	33-47	phenylethanolamine N-methyltransferase	Homo sapiens	0-4
26610136-3	2011	PNMT catalyzes the conversion of norepinephrine into epinephrine (adrenaline), and inhibitors of PNMT are of potential therapeutic importance in Alzheimer"s and Parkinson"s disease.	Norepinephrine	33-47	phenylethanolamine N-methyltransferase	Homo sapiens	97-101
21113058-8	2011	Overexpression of TFAM and TFB2M blocked hydrogen peroxide- and norepinephrine-induced decreases in Serca2a mRNA levels.	Norepinephrine	64-78	transcription factor A, mitochondrial	Rattus norvegicus	18-22
21113058-8	2011	Overexpression of TFAM and TFB2M blocked hydrogen peroxide- and norepinephrine-induced decreases in Serca2a mRNA levels.	Norepinephrine	64-78	transcription factor B2, mitochondrial	Rattus norvegicus	27-32
21302344-2	2011	Well-characterized common functional polymorphisms in the genes MAOA, COMT, and 5HTTLPR each have predictable effects on the availability of the monoamine neurotransmitters dopamine, noradrenaline, and serotonin.	Norepinephrine	183-196	catechol-O-methyltransferase	Homo sapiens	70-74
21266205-1	2011	Expression of hypophysiotropic TRH, that controls thyroid axis activity, is increased by cold exposure; this effect is mimicked in rat hypothalamic cells incubated with norepinephrine or cAMP analogs.	Norepinephrine	169-183	thyrotropin releasing hormone	Rattus norvegicus	31-34
21148479-3	2011	We propose the association of tyrosine hydroxylase immunoreactivity (THir) with image analysis to quantify norepinephrine (NE) content within nerve terminals in arteries/arterioles as a good index for regional sympathetic outflow.	Norepinephrine	107-121	tyrosine hydroxylase	Rattus norvegicus	30-50
21233615-5	2011	RESULTS: The reactivity of SMAs and VSMCs to norepinephrine after shock or hypoxia was positively correlated with changes in the RhoA and Rac1 activity ratio.	Norepinephrine	45-59	Rac family small GTPase 1	Rattus norvegicus	138-142
21785007-10	2011	Our results support the following sequence: (1) Starvation lowers blood glucose; (2) glucose-sensing neurons respond by activating sympathetic neurons; (3) norepinephrine, released in the stomach, stimulates ghrelin secretion; (4) ghrelin releases GH, which maintains blood glucose.	Norepinephrine	156-170	ghrelin	Mus musculus	208-215
21744996-7	2011	Finally, an in vitro study showed elevated proliferation of BP6-TU2 fibrosarcoma cells in response to adding norepinephrine to the culture medium.	Norepinephrine	109-123	Blood pressure QTL 6	Rattus norvegicus	60-63
21164545-9	2010	The protein expression of tyrosine hydroxylase (TH) increased in the hippocampus by FSM administration and it is suggested that FSM may change norepinephrine or dopamine signaling in the brain.	Norepinephrine	143-157	tyrosine hydroxylase	Rattus norvegicus	26-46
21164545-9	2010	The protein expression of tyrosine hydroxylase (TH) increased in the hippocampus by FSM administration and it is suggested that FSM may change norepinephrine or dopamine signaling in the brain.	Norepinephrine	143-157	tyrosine hydroxylase	Rattus norvegicus	48-50
20966530-0	2010	Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis.	Norepinephrine	82-95	nucleobindin 2	Rattus norvegicus	28-38
20966530-1	2010	A recently discovered satiety molecule, nesfatin-1, is localized in neurons of the hypothalamus and brain stem and colocalized with stress-related substances, corticotropin-releasing hormone (CRH), oxytocin, proopiomelanocortin, noradrenaline (NA) and 5-hydroxytryptamine (5-HT).	Norepinephrine	229-242	nucleobindin 2	Rattus norvegicus	40-50
20641662-0	2004	(+)-2-Hydroxy-3-isobutyl-9-(3-[(18)F]fluoropropoxy)-10-methoxy-1,2,3,4,6,7-hexahydro-11bH-benzo[a]quinolizine Vesicular monoamine transporter (VMAT2) is present in brain monoaminergic neurons and is responsible for collecting neurotransmitters (dopamine, norepinephrine, and serotonin) from the cytoplasm and storing them in vesicles for synaptic release (1).	Norepinephrine	255-269	solute carrier family 18 member A2	Homo sapiens	143-148
20809632-5	2010	On the one hand, (+)-1 increased the release of noradrenaline in mouse frontal cortex following acute systemic administration, the magnitude of this effect being much larger than that obtained with reference agents.	Norepinephrine	48-61	heart and neural crest derivatives expressed 1	Mus musculus	11-22
20521102-6	2010	Furthermore, intranasal NGF increased the levels of monoamine neurotransmitters (norepinephrine, dopamine) in the frontal cortex and hippocampus and affected the number of 5-bromodeoxyuridine (BrdU), c-fos and caspase-3 positive neurons in dentate gyrus of hippocampus in rats after UCMS.	Norepinephrine	81-95	nerve growth factor	Rattus norvegicus	24-27
20406625-12	2010	PDE4, but not PDE3, controls the atrial inotropic and cAMP beta(1)-adrenoceptor-mediated responses to (-)-noradrenaline.	Norepinephrine	102-119	adrenoceptor beta 1	Homo sapiens	59-79
22371762-1	2010	Catecholamine signaling pathways in the peripheral and central nervous systems (PNS, CNS, respectively) utilize catechol-O-methyltransferase (COMT) as a major regulatory enzyme responsible for deactivation of dopamine (DA), norepinephrine (NE) and epinephrine (E).	Norepinephrine	224-238	catechol-O-methyltransferase	Homo sapiens	112-140
22371762-1	2010	Catecholamine signaling pathways in the peripheral and central nervous systems (PNS, CNS, respectively) utilize catechol-O-methyltransferase (COMT) as a major regulatory enzyme responsible for deactivation of dopamine (DA), norepinephrine (NE) and epinephrine (E).	Norepinephrine	224-238	catechol-O-methyltransferase	Homo sapiens	142-146
19155075-8	2010	Concentrations of uric acid, epinephrine, and norepinephrine also correlated with ANP and BNP.	Norepinephrine	46-60	natriuretic peptide B	Homo sapiens	90-93
19629561-7	2010	Likewise, fibroblast growth factor 1, norepinephrine and angiotensin II as well as mechanical stretch were able to strongly induce Fn14 expression in cardiomyocytes.	Norepinephrine	38-52	tumor necrosis factor receptor superfamily, member 12a	Mus musculus	131-135
19883640-5	2010	In a concentration-dependent manner, rosuvastatin inhibited total protein synthesis and downregulated basal and norepinephrine-induced expressions of myosin light chain2 and the c-fos proto-oncogene in cardiomyocytes.	Norepinephrine	112-126	myosin light chain 2	Rattus norvegicus	150-169
20082610-8	2010	The vasoconstrictor responses to noradrenaline were augmented by indomethacin and by COX-2 inhibition in LZR but not in OZR.	Norepinephrine	33-46	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	85-90
20128806-1	2010	BACKGROUND AND PURPOSE: The alpha(2C)-adrenoceptor has multiple functions, including inhibiting release of noradrenaline from presynaptic nerve terminals.	Norepinephrine	107-120	adrenoceptor alpha 2C	Homo sapiens	28-50
20043878-5	2010	In differentiated adipocytes, CCDC3 mRNA expression was enhanced by insulin and pioglitazone, a PPARgamma agonist, and suppressed by TNF-alpha, isoproterenol and norepinephrine.	Norepinephrine	162-176	coiled-coil domain containing 3	Mus musculus	30-35
19910579-4	2010	METHODS AND RESULTS: We report that MAO-A activity is triggered in isolated neonatal and adult myocytes on stimulation with norepinephrine, followed by increase in cell size, reactive oxygen species production, and signs of maladaptive hypertrophy.	Norepinephrine	124-138	monoamine oxidase A	Mus musculus	36-41
19910579-6	2010	In mice with left ventricular dilation and pump failure attributable to pressure overload, norepinephrine catabolism by MAO-A is increased accompanied by exacerbated oxidative stress.	Norepinephrine	91-105	monoamine oxidase A	Mus musculus	120-125
20064241-0	2010	Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia.	Norepinephrine	0-14	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	54-59
20064241-5	2010	In the present study, we investigate the role of norepinephrine on cyclooxygenase- (COX-)2 expression/synthesis and prostaglandin (PG)E2 production in rat primary microglia.	Norepinephrine	49-63	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	84-90
20064241-6	2010	RESULTS: Interestingly, norepinephrine increased COX-2 mRNA, but not protein expression.	Norepinephrine	24-38	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	49-54
20064241-7	2010	Norepinephrine strongly enhanced COX-2 expression and PGE2 production induced by lipopolysaccharide (LPS).	Norepinephrine	0-14	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	33-38
20064241-9	2010	Furthermore, beta-adrenoreceptor antagonists blocked the enhancement of COX-2 levels induced by norepinephrine and beta-adrenoreceptor agonists.	Norepinephrine	96-110	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	72-77
19880803-0	2010	An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure.	Norepinephrine	55-69	adrenoceptor alpha 2C	Homo sapiens	3-30
19724290-8	2010	Incidence of ICH and levels of oxidative stress and MMP-9 were greater in mice with acute hypertension produced by AngII than by norepinephrine.	Norepinephrine	129-143	matrix metallopeptidase 9	Mus musculus	52-57
19482560-1	2009	In this study we investigated the changes in norepinephrine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) gene expression in the stellate ganglia of naive controls and long-term socially isolated (12 weeks) adult rats and the response of these animals to additional immobilization stress.	Norepinephrine	45-59	tyrosine hydroxylase	Rattus norvegicus	81-101
19482560-1	2009	In this study we investigated the changes in norepinephrine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) gene expression in the stellate ganglia of naive controls and long-term socially isolated (12 weeks) adult rats and the response of these animals to additional immobilization stress.	Norepinephrine	45-59	tyrosine hydroxylase	Rattus norvegicus	103-105
19573018-7	2009	Transfection of shRNAs specific to Phox2a or Phox2b genes significantly reduced mRNA and protein levels of NET and DBH after shutdown of endogenous Phox2, which was accompanied by a decreased [(3)H]norepinephrine uptake.	Norepinephrine	198-212	paired like homeobox 2A	Homo sapiens	35-41
19570037-0	2009	Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity.	Norepinephrine	49-62	phenylethanolamine N-methyltransferase	Homo sapiens	101-105
19570037-3	2009	Here we report the crystal structures of six human PNMT complexes, including the first structure of the enzyme in complex with its physiological ligand R-noradrenaline.	Norepinephrine	152-167	phenylethanolamine N-methyltransferase	Homo sapiens	51-55
19570037-6	2009	The crystal structures illustrate the adaptability of the PNMT substrate binding site in accepting multi-fused ring systems, such as substituted norbornene, as well as noradrenochrome, the oxidation product of noradrenaline.	Norepinephrine	210-223	phenylethanolamine N-methyltransferase	Homo sapiens	58-62
19457070-4	2009	TNF-alpha shed in response to PrP(C) acts as a second message signal, eliciting serotonin (5-HT) or norepinephrine (NE) degradation in 1C11(5-HT) or 1C11(NE) cells, respectively.	Norepinephrine	100-114	prion protein	Mus musculus	30-36
19351665-0	2009	Ghrelin suppresses noradrenaline release in the brown adipose tissue of rats.	Norepinephrine	19-32	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
19351665-1	2009	To clarify the role of ghrelin in the regulatory mechanism of energy metabolism, we analyzed the effects of centrally and peripherally administered ghrelin on noradrenaline release in the brown adipose tissue (BAT) of rats using a microdialysis system.	Norepinephrine	159-172	ghrelin and obestatin prepropeptide	Rattus norvegicus	148-155
19351665-3	2009	administration of ghrelin at a dose of 500 pmol suppressed noradrenaline release in BAT, and microinjection of ghrelin (50 pmol) into the paraventricular nucleus (PVN) or arcuate nucleus (ARC) of the hypothalamus also suppressed noradrenaline release in BAT.	Norepinephrine	59-72	ghrelin and obestatin prepropeptide	Rattus norvegicus	18-25
19374521-1	2009	Catechol-O-methyltransferase (COMT) is an enzyme that inactivates biologically-active catechols, including the important neurotransmitters dopamine, noradrenaline and adrenaline.	Norepinephrine	149-162	catechol-O-methyltransferase	Homo sapiens	0-28
19374521-1	2009	Catechol-O-methyltransferase (COMT) is an enzyme that inactivates biologically-active catechols, including the important neurotransmitters dopamine, noradrenaline and adrenaline.	Norepinephrine	149-162	catechol-O-methyltransferase	Homo sapiens	30-34
19025979-1	2009	Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates bidirectional, sodium-independent transport of dopamine, norepinephrine, epinephrine, serotonin, and histamine.	Norepinephrine	152-166	solute carrier family 22 member 3	Rattus norvegicus	0-28
19025979-1	2009	Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates bidirectional, sodium-independent transport of dopamine, norepinephrine, epinephrine, serotonin, and histamine.	Norepinephrine	152-166	solute carrier family 22 member 3	Rattus norvegicus	30-34
19020050-5	2008	Conversely, the transfection of synthetic anti-miR oligonucleotides that inhibit miR-338 increases COXIV levels, and results in a significant increase in oxidative phosphorylation and also norepinephrine uptake in the axons.	Norepinephrine	189-203	cytochrome c oxidase subunit 4I1	Homo sapiens	99-104
18722504-1	2008	Local application of alphabetaMeATP (ligand for P2X3 receptors) and capsaicin (ligand for TRPV1 receptors) to the rat hindpaw produces pain behaviors (flinching) which are enhanced by noradrenaline (NA).	Norepinephrine	184-197	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	90-95
18947427-2	2008	Polymorphisms of this gene are known to alter receptor function or expression, as are polymorphisms of the alpha 2C-adrenergic receptor, which regulates norepinephrine release from cardiac presynaptic nerves.	Norepinephrine	153-167	adrenoceptor alpha 2C	Homo sapiens	107-135
18761356-7	2008	However, obese mice lacking CD14 presented decreased lipid and macrophage content in hepatic and adipose tissues, lower urinary levels of noradrenaline, decreased systolic blood pressure, reduced fasting plasma glucose and blunted glucose intolerance, compared with obese WT group.	Norepinephrine	138-151	CD14 antigen	Mus musculus	28-32
18516067-5	2008	KEY RESULTS: The potency of the alpha1A-adrenoceptor selective agonist A61603 (pEC50=7.79+/-0.04) was 158-fold greater than that for noradrenaline (pEC50=5.59+/-0.02).	Norepinephrine	133-146	adrenoceptor alpha 1A	Sus scrofa	32-39
18516067-7	2008	The alpha1D-adrenoceptor selective antagonist BMY7378 caused rightward shifts of the concentration-response curves to phenylephrine and noradrenaline, yielding low affinity estimates of 6.59+/-0.15 and 6.33+/-0.13, respectively.	Norepinephrine	136-149	alpha-1D adrenergic receptor	Sus scrofa	4-24
18516067-8	2008	Relatively high affinity estimates were obtained for the alpha1A-adrenoceptor selective antagonists, RS100329 (9.01+/-0.14 and 9.06+/-0.22 with phenylephrine and noradrenaline, respectively) and 5-methylurapidil (8.51+/-0.10 and 8.31+/-0.10, respectively).	Norepinephrine	162-175	adrenoceptor alpha 1A	Sus scrofa	57-64
18492725-4	2008	GluR-A(-/-) mice display increased learned helplessness, decreased serotonin and norepinephrine levels, and disturbed glutamate homeostasis with increased glutamate levels and increased NMDA receptor expression.	Norepinephrine	81-95	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	0-6
18492776-7	2008	Importantly, in the presence of the PPARgamma agonist the brown adipocyte phenotype was significantly enhanced: UCP1 was expressed even in the absence of norepinephrine, and PPARalpha expression and norepinephrine-induced PGC-1alpha mRNA levels were significantly increased.	Norepinephrine	154-168	peroxisome proliferator activated receptor gamma	Mus musculus	36-45
18492776-7	2008	Importantly, in the presence of the PPARgamma agonist the brown adipocyte phenotype was significantly enhanced: UCP1 was expressed even in the absence of norepinephrine, and PPARalpha expression and norepinephrine-induced PGC-1alpha mRNA levels were significantly increased.	Norepinephrine	199-213	peroxisome proliferator activated receptor gamma	Mus musculus	36-45
18492776-7	2008	Importantly, in the presence of the PPARgamma agonist the brown adipocyte phenotype was significantly enhanced: UCP1 was expressed even in the absence of norepinephrine, and PPARalpha expression and norepinephrine-induced PGC-1alpha mRNA levels were significantly increased.	Norepinephrine	199-213	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	222-232
18670361-0	2008	Angiotensin II type 2 receptor-mediated inhibition of norepinephrine release in isolated rat hearts.	Norepinephrine	54-68	angiotensin II receptor, type 2	Rattus norvegicus	0-30
18807729-3	2008	Noradrenaline (NE) synthesis/release was modulated by exogenous NO donor and selective inhibitor of nNOS in the skin acupoints/meridians.	Norepinephrine	0-13	nitric oxide synthase 1	Homo sapiens	100-104
18343456-7	2008	Plasma noradrenalin level was significantly elevated at every time point until 24 h. Guanethidine pretreatment eliminated the delay in gastric emptying at 8 h. Active ghrelin was significantly increased on days 3 and 5 after peak (at 24 h) plasma total and desacyl ghrelin in the stress group.	Norepinephrine	7-19	ghrelin and obestatin prepropeptide	Rattus norvegicus	167-174
18310457-1	2008	3,4-Dihydroxyphenylalanine decarboxylase (DDC; also known as l-amino acid decarboxylase) is involved in the synthesis of dopamine, norepinephrine, and serotonin, and also acts as an androgen receptor co-regulator protein.	Norepinephrine	131-145	dopa decarboxylase	Mus musculus	0-40
18310457-1	2008	3,4-Dihydroxyphenylalanine decarboxylase (DDC; also known as l-amino acid decarboxylase) is involved in the synthesis of dopamine, norepinephrine, and serotonin, and also acts as an androgen receptor co-regulator protein.	Norepinephrine	131-145	dopa decarboxylase	Mus musculus	42-45
18191822-0	2008	Systemic administration of leptin decreases plasma corticosterone levels: role of hypothalamic norepinephrine.	Norepinephrine	95-109	leptin	Rattus norvegicus	27-33
18191822-3	2008	Since norepinephrine (NE) is a key regulator of the HPA axis, we hypothesized that leptin could suppress HPA activity by decreasing NE levels.	Norepinephrine	6-20	leptin	Rattus norvegicus	83-89
18257749-2	2008	2 Inhibitors of this kinase (PP2 and Src Inhibitor II) decreased ( approximately 50-75%) noradrenaline- (NA) and phorbol myristate acetate-mediated receptor phosphorylation.	Norepinephrine	89-102	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	29-32
18257750-0	2008	Peripheral administration of CDP-choline, phosphocholine or choline increases plasma adrenaline and noradrenaline concentrations.	Norepinephrine	100-113	cut like homeobox 1	Homo sapiens	29-32
18257750-2	2008	injection of 200-600 mumol/kg of cytidine-5"-diphosphocholine (CDP-choline) increased plasma adrenaline and noradrenaline concentrations dose- and time-dependently.	Norepinephrine	108-121	cut like homeobox 1	Homo sapiens	63-66
18071301-8	2008	Activation of CB1 in sympathetic nerve terminals in bone inhibits norepinephrine release, thus balancing the tonic sympathetic restrain of bone formation.	Norepinephrine	66-80	cannabinoid receptor 1 (brain)	Mus musculus	14-17
18060386-7	2008	In the LC, 1 mg/kg of Wf-516 dampened the inhibitory effect of the preferential 5-HT(2A) agonist DOI on norepinephrine (NE) neurons, indicating that Wf-516 is also a 5-HT(2A) receptor antagonist.	Norepinephrine	104-118	5-hydroxytryptamine receptor 2A	Rattus norvegicus	80-87
17410123-0	2007	Presynaptic alpha-2C adrenoceptor-mediated control of noradrenaline release in humans: genotype- or age-dependent?	Norepinephrine	54-67	adrenoceptor alpha 2C	Homo sapiens	12-33
18093408-4	2007	The ARB eprosartan, in contrast to other ARBs, also inhibits prejunctional AT1 receptors, which regulate noradrenaline release.	Norepinephrine	105-118	angiotensin II receptor type 1	Homo sapiens	75-78
17827867-0	2007	Characterization of noradrenaline-induced increases in intracellular Ca2+ levels in Chinese hamster ovary cells stably expressing human alpha1A-adrenoceptor.	Norepinephrine	20-33	adrenoceptor alpha 1A	Homo sapiens	136-156
17827867-1	2007	The mechanism for noradrenaline (NA)-induced increases in intracellular Ca(2+) concentration ([Ca(2+)](i)) and physiological significance of Na(+) influx through receptor-operated channels (ROCs) and store-operated channels (SOCs) were studied in Chinese hamster ovary (CHO) cells stably expressing human alpha(1A)-adrenoceptor (alpha(1A)-AR).	Norepinephrine	18-31	adrenoceptor alpha 1A	Homo sapiens	305-327
17577585-1	2007	In differentiating red blood cells (RBCs) of the chick embryo, the synthesis of carbonic anhydrase (CAII) and pyrimidine 5"-nucleotidase (P5N-I) is triggered by the hypoxic mediators norepinephrine and adenosine via receptor-mediated cAMP formation.	Norepinephrine	183-197	carbonic anhydrase 2	Gallus gallus	100-104
17559824-12	2007	Finally, stimulation of non-failing SHR cardiomyocytes with angiotensin II, aldosterone, norepinephrine or endothelin-1 significantly decreased (p&lt;0.01) LIFR expression.	Norepinephrine	89-103	LIF receptor subunit alpha	Rattus norvegicus	156-160
17645789-2	2007	One candidate gene is PNMT, coding for phenylethanolamine-N-methyltransferase, catalyzing the synthesis of epinephrine from norepinephrine.	Norepinephrine	124-138	phenylethanolamine N-methyltransferase	Homo sapiens	22-26
17645789-2	2007	One candidate gene is PNMT, coding for phenylethanolamine-N-methyltransferase, catalyzing the synthesis of epinephrine from norepinephrine.	Norepinephrine	124-138	phenylethanolamine N-methyltransferase	Homo sapiens	39-77
17581215-2	2007	The effects of adenosine and ATP receptor agonists on the release of endogenous noradrenaline from electrically stimulated (2 Hz, 0.1 msec) rat prostate were examined in order to clarify the pharmacological properties of prejunctional receptors for adenosine and ATP on the adrenergic nerve varicosities in the prostate.	Norepinephrine	80-93	purinergic receptor P2X 6	Rattus norvegicus	29-41
17581215-5	2007	Both adenosine and ATP receptor agonists (1 micromol/L) inhibited noradrenaline release and the relative order of inhibitory effect was N(6)-cyclopentyl-adenosine (CPA) &gt; 5"-N-ethylcarboxamidoadenosine &gt; 2-chloroadenosine &gt; adenosine &gt; 2-methylthio-ATP (2mSATP) &gt; AMP &gt; ATP.	Norepinephrine	66-79	purinergic receptor P2X 6	Rattus norvegicus	19-31
17581215-7	2007	The adenosine receptor agonist CPA (1 nmol/L-1 micromol/L) and the ATP receptor agonist 2mSATP (100 nmol/L-100 micromol/L) inhibited the stimulation-induced release of noradrenaline in a concentration-dependent manner.	Norepinephrine	168-181	purinergic receptor P2X 6	Rattus norvegicus	67-79
17515454-8	2007	Inhibition of Rac1, induced by transfecting adenovirus vectors encoding dominant-negative Rac1 into the NTS, decreased blood pressure, heart rate, and urinary norepinephrine excretion in SHRSPs but not in Wistar-Kyoto rats.	Norepinephrine	159-173	Rac family small GTPase 1	Rattus norvegicus	14-18
17592033-0	2007	Estrogen inhibition of norepinephrine responsiveness is initiated at the plasma membrane of GnRH-producing GT1-7 cells.	Norepinephrine	23-37	myosin, light polypeptide 4	Mus musculus	107-110
17493708-1	2007	This work aimed to investigate the molecular mechanisms involved in the interaction of alpha2-adrenoceptors and adenosine A2A-receptor-mediated facilitation of noradrenaline release in rat tail artery, namely the type of G-protein involved in this effect and the step or steps where the signalling cascades triggered by alpha2-adrenoceptors and A2A-receptors interact.	Norepinephrine	160-173	adenosine A2a receptor	Rattus norvegicus	112-134
17234900-4	2007	TAAR1 activation by monoamines and amphetamine-related compounds was greatly enhanced by coexpression of dopamine, norepinephrine, or serotonin transporters, and the activation enhancement was blocked by monoamine transporter inhibitors.	Norepinephrine	115-129	trace amine associated receptor 1	Macaca mulatta	0-5
17242297-8	2007	Both also reduced (P&lt;0.05) cyclooxygenase-2 mRNA and protein expression in PVN, cerebrospinal fluid prostaglandin E2, and plasma norepinephrine.	Norepinephrine	132-146	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	30-46
17179444-10	2007	The receptor agonist noradrenaline, which induced a rapid increase in the [Ca2+]i and Ca2+-dependent contraction, stimulated phosphorylation of MYPT1 and MLC, which was also dependent on Ca2+, PI3K-C2alpha, and Rho-kinase.	Norepinephrine	21-34	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	144-149
17179444-10	2007	The receptor agonist noradrenaline, which induced a rapid increase in the [Ca2+]i and Ca2+-dependent contraction, stimulated phosphorylation of MYPT1 and MLC, which was also dependent on Ca2+, PI3K-C2alpha, and Rho-kinase.	Norepinephrine	21-34	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	193-205
16897602-1	2007	Catechol-O-methyltransferase (COMT) gene is one of the candidate genes for schizophrenia because it codes an enzyme that participates in the metabolic inactivation of dopamine and noradrenaline and a limiting factor of dopamine metabolism in the prefrontal cortex.	Norepinephrine	180-193	catechol-O-methyltransferase	Homo sapiens	0-28
16897602-1	2007	Catechol-O-methyltransferase (COMT) gene is one of the candidate genes for schizophrenia because it codes an enzyme that participates in the metabolic inactivation of dopamine and noradrenaline and a limiting factor of dopamine metabolism in the prefrontal cortex.	Norepinephrine	180-193	catechol-O-methyltransferase	Homo sapiens	30-34
17441000-1	2007	Monoamine oxidase A (MAO A) degrades serotonin, dopamine and noradrenaline, factors critically involved in the regulation of aggression.	Norepinephrine	61-74	monoamine oxidase A	Mus musculus	0-19
17441000-1	2007	Monoamine oxidase A (MAO A) degrades serotonin, dopamine and noradrenaline, factors critically involved in the regulation of aggression.	Norepinephrine	61-74	monoamine oxidase A	Mus musculus	21-26
17213482-6	2007	Treatment with ANG-(1-7) or AVE-0991 also prevented the diabetes-induced abnormal vascular responsiveness to norepinephrine, endothelin-1, angiotensin II, carbachol, and histamine in the perfused mesenteric bed and isolated carotid and renal arteries.	Norepinephrine	109-123	angiopoietin 1	Homo sapiens	15-23
16962210-0	2006	Involvement of G-protein betagamma subunits on the influence of inhibitory alpha2-autoreceptors on the angiotensin AT1-receptor modulation of noradrenaline release in the rat vas deferens.	Norepinephrine	142-155	angiotensin II receptor, type 1a	Rattus norvegicus	115-118
16962210-7	2006	The results indicate that activation of AT1-receptors coupled to the PLC-PKC pathway enhances noradrenaline release, an effect that is markedly favoured by an ongoing activation of alpha2-autoreceptors.	Norepinephrine	94-107	angiotensin II receptor, type 1a	Rattus norvegicus	40-43
16982607-7	2006	Importantly, activation of endogenous cAMP-coupled beta-adrenergic receptors with norepinephrine stimulated the phosphorylation of FRAT1 at Ser188.	Norepinephrine	82-96	frequently rearranged in advanced T-cell lymphomas 1 S homeolog	Xenopus laevis	131-136
27647490-4	2016	Acute noradrenaline-induced hyperthermia requires UCP1 but not UCP3.	Norepinephrine	6-19	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	50-54
27650061-0	2016	Norepinephrine inhibits mesenchymal stem cell chemotaxis migration by increasing stromal cell-derived factor-1 secretion by vascular endothelial cells via NE/abrd3/JNK pathway.	Norepinephrine	0-14	C-X-C motif chemokine ligand 12	Rattus norvegicus	81-110
27658936-1	2016	Aromatic l-amino acid decarboxylase (AADC) deficiency is an inborn error of monoamine neurotransmitter synthesis, which results in dopamine, serotonin, epinephrine and norepinephrine deficiencies.	Norepinephrine	168-182	dopa decarboxylase	Mus musculus	0-35
27658936-1	2016	Aromatic l-amino acid decarboxylase (AADC) deficiency is an inborn error of monoamine neurotransmitter synthesis, which results in dopamine, serotonin, epinephrine and norepinephrine deficiencies.	Norepinephrine	168-182	dopa decarboxylase	Mus musculus	37-41
30193444-10	2016	The activation of peripheral CB1 receptors leads to inhibition of norepinephrine release from sympathetic terminals and epinephrine release from the adrenal glands.	Norepinephrine	66-80	cannabinoid receptor 1 (brain)	Mus musculus	29-32
27057952-1	2016	AIM: 22q11.2 deletion syndrome (22q11.2DS) affects catechol-O-methyl-transferase (COMT), which involves the degradation of norepinephrine (NE).	Norepinephrine	123-137	catechol-O-methyltransferase	Homo sapiens	51-80
27057952-1	2016	AIM: 22q11.2 deletion syndrome (22q11.2DS) affects catechol-O-methyl-transferase (COMT), which involves the degradation of norepinephrine (NE).	Norepinephrine	123-137	catechol-O-methyltransferase	Homo sapiens	82-86
26801309-8	2016	HF rats treated with ERK1/2 siRNAs also had reduced PVN neuronal excitation (fewer Fos-related antigen-like-immunoreactive neurons), lower plasma norepinephrine levels, and improved peripheral manifestations of HF compared with HF rats treated with control siRNAs.	Norepinephrine	146-160	mitogen activated protein kinase 3	Rattus norvegicus	21-27
26773917-1	2016	BACKGROUND: Catechol-O-methyltransferase (COMT) is a catabolic enzyme involved in the degradation of bioactive molecules including the neurotransmitters epinephrine, norepinephrine, and dopamine.	Norepinephrine	166-180	catechol-O-methyltransferase	Homo sapiens	12-40
26773917-1	2016	BACKGROUND: Catechol-O-methyltransferase (COMT) is a catabolic enzyme involved in the degradation of bioactive molecules including the neurotransmitters epinephrine, norepinephrine, and dopamine.	Norepinephrine	166-180	catechol-O-methyltransferase	Homo sapiens	42-46
26772978-3	2016	Tyrosine hydroxylase (TH) is the key enzyme for the synthesis of catecholamines, including dopamine and noradrenaline, and it is normally not expressed in cerebellar neurons.	Norepinephrine	104-117	tyrosine hydroxylase	Mus musculus	0-20
26772978-3	2016	Tyrosine hydroxylase (TH) is the key enzyme for the synthesis of catecholamines, including dopamine and noradrenaline, and it is normally not expressed in cerebellar neurons.	Norepinephrine	104-117	tyrosine hydroxylase	Mus musculus	22-24
26393369-1	2015	The isozymes of monoamine oxidase (MAO-A and MAO-B) are important enzymes involved in the metabolism of numerous biogenic amines, including the neurotransmitters serotonin, dopamine, and norepinephrine.	Norepinephrine	187-201	monoamine oxidase A	Rattus norvegicus	35-40
26506851-5	2015	During acute hypoglycemia, leptin decreased glucagon responses by 51% but increased epinephrine and norepinephrine by 24 and 48%, respectively.	Norepinephrine	100-114	leptin	Rattus norvegicus	27-33
26432838-0	2015	Organic cation transporter 3 contributes to norepinephrine uptake into perivascular adipose tissue.	Norepinephrine	44-58	solute carrier family 22 member 3	Rattus norvegicus	0-28
26432356-4	2015	In this report, evidence is presented that (1) both the recently discovered cAMP-regulated transcriptional coactivators (CRTCs) and salt-inducible kinase 1 (SIK1) contribute to the transcriptional regulation of atp1b1 in renal proximal tubule (RPT) cells and (2) renal effectors, including norepinephrine, dopamine, prostaglandins, and sodium, play a role.	Norepinephrine	290-304	ATPase Na+/K+ transporting subunit beta 1	Homo sapiens	211-217
26403854-6	2015	The correlation between renalase and noradrenalin concentration in blood was observed (r = 0.549; P &lt; .05), also the correlation between VAP-1 and noradrenaline was noticed (r = 0.21, P = .029).	Norepinephrine	150-163	amine oxidase copper containing 3	Homo sapiens	140-145
26190182-0	2015	Anti-inflammatory effects of noradrenaline on LPS-treated microglial cells: Suppression of NFkappaB nuclear translocation and subsequent STAT1 phosphorylation.	Norepinephrine	29-42	signal transducer and activator of transcription 1	Rattus norvegicus	137-142
26123527-11	2015	There was a secondary, norepinephrine independent SBP rise in patients with severe global vasospasm that significantly correlated with the initial Hijdra-scale and an unfavorable clinical outcome.	Norepinephrine	23-37	selenium binding protein 1	Homo sapiens	50-53
26265044-9	2015	Cell viability tests also indicated that miR-17 pretreatment significantly prevented the norepinephrine-induced apoptosis of cardiomyocytes, suggesting that down-regulation of apoptosome formation may be an effective strategy to prevent cellular apoptosis.	Norepinephrine	89-103	microRNA 17	Homo sapiens	41-47
26010653-1	2015	OBJECTIVE: Catechol-O-methyltransferase (COMT) is an enzyme that participates in the metabolic inactivation of dopamine and norepinephrine, and the Met allele of the COMT Val158Met polymorphism is associated with lower enzymatic activity.	Norepinephrine	124-138	catechol-O-methyltransferase	Homo sapiens	11-39
26010653-1	2015	OBJECTIVE: Catechol-O-methyltransferase (COMT) is an enzyme that participates in the metabolic inactivation of dopamine and norepinephrine, and the Met allele of the COMT Val158Met polymorphism is associated with lower enzymatic activity.	Norepinephrine	124-138	catechol-O-methyltransferase	Homo sapiens	41-45
26010653-1	2015	OBJECTIVE: Catechol-O-methyltransferase (COMT) is an enzyme that participates in the metabolic inactivation of dopamine and norepinephrine, and the Met allele of the COMT Val158Met polymorphism is associated with lower enzymatic activity.	Norepinephrine	124-138	catechol-O-methyltransferase	Homo sapiens	166-170
26596036-4	2015	From the second day the constant infusion of norepinephrine was necessary to maintain mean ABP above 80 mmHg.	Norepinephrine	45-59	amine oxidase copper containing 1	Homo sapiens	91-94
26596036-6	2015	Developed hyperthermia to 40, 2  and cardiovascular collapse (in spite of the high level of norepinephrine support a sharp decline in ABP up to 49/20 mmHg).	Norepinephrine	92-106	amine oxidase copper containing 1	Homo sapiens	134-137
25651802-2	2015	Our previous results have demonstrated slower kinetics of transmitter release (glutamate release in hippocampus and norepinephrine release in adrenal slice) in a schizophrenia model, dysbindin null-sandy mice.	Norepinephrine	116-130	dystrobrevin binding protein 1	Mus musculus	183-192
25904086-4	2015	Blood pressure and renal noradrenaline content were lower in SHR receiving anti-NGF than in SHR receiving vehicle, although such difference was not observed in WKY rats.	Norepinephrine	25-38	nerve growth factor	Rattus norvegicus	80-83
25904086-6	2015	Blood pressure and renal noradrenaline content remained greater in SHR treated with anti-NGF compared with WKY rats treated with vehicle; however, the gradient of F-P did not differ significantly between them.	Norepinephrine	25-38	nerve growth factor	Rattus norvegicus	89-92
25594617-0	2015	Noradrenaline enhances angiotensin II responses via p38 MAPK activation after hypoxia/re-oxygenation in renal interlobar arteries.	Norepinephrine	0-13	mitogen-activated protein kinase 14	Mus musculus	52-55
25790239-4	2015	The alpha1A -adrenoceptor selective agonist A61603 was a full agonist and was 250-fold more potent than noradrenaline.	Norepinephrine	104-117	adrenoceptor alpha 1A	Homo sapiens	4-25
25758202-5	2015	Betaine does this most likely by supporting the methylation of norepinephrine to form epinephrine by phenylethanolamine N-methyltransferase.	Norepinephrine	63-77	phenylethanolamine N-methyltransferase	Homo sapiens	101-139
26054146-7	2015	The general condition, open-field experimental result and gastric ulcer index were observed; the western blotting method was applied to measure the expression of vanilloid receptor subtype 1 (VR1) in hypothalamus and gastric antral mucosal, and ELISA method was applied to test the expression of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in hippocampus.	Norepinephrine	327-341	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	192-195
25799564-9	2015	It was observed that when alpha1B-adrenergic receptors were stimulated with noradrenaline, the receptors interacted with proteins present in early endosomes, such as the early endosomes antigen 1, Rab 5, Rab 4, and Rab 11 but not with late endosome markers, such as Rab 9 and Rab 7.	Norepinephrine	76-89	RAB11A, member RAS oncogene family	Homo sapiens	215-221
25890242-8	2015	The effects on neuromodulator temporal dynamics were sensitive to the Monoamine oxidase-A (MAO-A) antagonist clorgyline (for norepinephrine and serotonin) and the ACh-E inhibitor donepezil (for acetylcholine).	Norepinephrine	125-139	monoamine oxidase A	Mus musculus	91-96
25208620-0	2015	Norepinephrine Protects against Amyloid-beta Toxicity via TrkB.	Norepinephrine	0-14	neurotrophic receptor tyrosine kinase 2	Homo sapiens	58-62
25543537-8	2014	In addition, we detected increased norepinephrine in the circulation, and observed that GHS-R knockdown in brown adipocytes directly stimulates thermogenic activity, suggesting that GHS-R regulates thermogenesis via both central and peripheral mechanisms.Collectively, our studies demonstrate that ghrelin signaling is an important thermogenic regulator in aging.	Norepinephrine	35-49	growth hormone secretagogue receptor	Homo sapiens	182-187
25283507-0	2014	Selective alpha1B- and alpha1D-adrenoceptor antagonists suppress noradrenaline-induced activation, proliferation and ECM secretion of rat hepatic stellate cells in vitro.	Norepinephrine	65-78	adrenoceptor alpha 1D	Rattus norvegicus	23-43
25085924-8	2014	In T37i cells, corticosterone prevented induction of Ucp1 mRNA and Ucp1 protein by both ACTH and norepinephrine in a glucocorticoid receptor (GR)-dependent fashion.	Norepinephrine	97-111	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	53-57
25085924-8	2014	In T37i cells, corticosterone prevented induction of Ucp1 mRNA and Ucp1 protein by both ACTH and norepinephrine in a glucocorticoid receptor (GR)-dependent fashion.	Norepinephrine	97-111	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	67-71
25131562-8	2014	Triple-labeling immunocytochemistry revealed that alpha2A-AR and CB1R were localised to processes that contained dopamine-beta-hydroxylase, a marker of norepinephrine.	Norepinephrine	152-166	adrenoceptor alpha 2A	Rattus norvegicus	50-60
24535841-0	2014	Neuropeptide y attenuates stress-induced bone loss through suppression of noradrenaline circuits.	Norepinephrine	74-87	neuropeptide Y	Mus musculus	0-14
24535841-9	2014	Importantly, specific reintroduction of NPY solely in noradrenergic neurons of otherwise Npy-null mice blocks the increase in circulating noradrenaline and the stress-induced bone loss.	Norepinephrine	138-151	neuropeptide Y	Mus musculus	40-43
24929186-0	2014	Quercetin-3-O-glucuronide inhibits noradrenaline-promoted invasion of MDA-MB-231 human breast cancer cells by blocking beta2-adrenergic signaling.	Norepinephrine	35-48	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	119-124
24777411-3	2014	The result showed that, under normoxic conditions, Cl(Ca) inhibitors (NFA and IAA-94) significantly relaxed second pulmonary artery contracted by norepinephrine (P &lt; 0.01), but merely had effects on KCl-induced second pulmonary artery contractions.	Norepinephrine	146-160	chloride channel accessory 5	Rattus norvegicus	51-57
24332566-3	2014	In this study we investigated whether NGF synthesis by CG neurons is altered in heart failure, and whether norepinephrine from sympathetic neurons promotes NGF synthesis.	Norepinephrine	107-121	nerve growth factor	Rattus norvegicus	156-159
24332566-7	2014	To further investigate norepinephrine"s role in promoting NGF synthesis, we cultured CG neurons treated with adrenergic receptor (AR) agonists.	Norepinephrine	23-37	nerve growth factor	Rattus norvegicus	58-61
24285555-2	2014	Here, we examined the contribution of norepinephrine to the catecholamine release in the mPFC evoked by electrical stimulation of the ventral tegmental area (VTA).	Norepinephrine	38-52	complement factor properdin	Mus musculus	89-93
24118769-7	2014	Exposure of primary cultures of proximal tubular cells to noradrenaline increased brush border NHE3 abundance and activity which was blocked by prior exposure to prazosin, indicating it as an alpha1 -adrenoceptor-mediated mechanism.	Norepinephrine	58-71	solute carrier family 9 member A3	Rattus norvegicus	95-99
24304472-0	2014	alpha1 adrenoceptor activation by norepinephrine inhibits LPS-induced cardiomyocyte TNF-alpha production via modulating ERK1/2 and NF-kappaB pathway.	Norepinephrine	34-48	mitogen activated protein kinase 3	Rattus norvegicus	120-126
24354565-2	2014	Methylation of the meta-hydroxyl is much more common than that of the para-hydroxyl in many COMT substrates, such as dopamine and norepinephrine.	Norepinephrine	130-144	catechol-O-methyltransferase	Homo sapiens	92-96
23581564-2	2014	MAO-A contributes to heart failure progression via enhanced norepinephrine catabolism and oxidative stress.	Norepinephrine	60-74	monoamine oxidase A	Mus musculus	0-5
23505234-13	2014	CONCLUSIONS: These data indicate that IL7R+ B cells have a proinflammatory role in arthritis which can be inhibited by the sympathetic neurotransmitter norepinephrine via inhibition of IL-7R signalling.	Norepinephrine	152-166	interleukin 7 receptor	Homo sapiens	38-42
23505234-13	2014	CONCLUSIONS: These data indicate that IL7R+ B cells have a proinflammatory role in arthritis which can be inhibited by the sympathetic neurotransmitter norepinephrine via inhibition of IL-7R signalling.	Norepinephrine	152-166	interleukin 7 receptor	Homo sapiens	185-190
24058188-3	2014	ATP acting on LC P2 receptors influences the release of noradrenaline.	Norepinephrine	56-69	lymphocyte cytosolic protein 2	Rattus norvegicus	14-19
25069611-4	2014	Renal ischemia/reperfusion increased blood urea nitrogen and plasma creatinine and expression of tyrosine hydroxylase, a rate-limiting enzyme for the biosynthesis of noradrenaline, in the kidney.	Norepinephrine	166-179	tyrosine hydroxylase	Mus musculus	97-117
24396707-1	2013	Phenylethanolamine n-methyltransferase (Pnmt) catalyzes the conversion of norepinephrine into epinephrine, and thus serves as a marker of adrenergic cells.	Norepinephrine	74-88	phenylethanolamine N-methyltransferase	Homo sapiens	0-38
24396707-1	2013	Phenylethanolamine n-methyltransferase (Pnmt) catalyzes the conversion of norepinephrine into epinephrine, and thus serves as a marker of adrenergic cells.	Norepinephrine	74-88	phenylethanolamine N-methyltransferase	Homo sapiens	40-44
23926250-1	2013	Monoamine oxidase A (MAO-A), the catabolic enzyme of norepinephrine and serotonin, plays a critical role in emotional and social behavior.	Norepinephrine	53-67	monoamine oxidase A	Mus musculus	0-19
23926250-1	2013	Monoamine oxidase A (MAO-A), the catabolic enzyme of norepinephrine and serotonin, plays a critical role in emotional and social behavior.	Norepinephrine	53-67	monoamine oxidase A	Mus musculus	21-26
23843937-6	2013	Pre- and post-synaptic stimulation of beta1-adrenergic receptors (BAR) with nicotine and noradrenaline, respectively, resulted in an increase of the spontaneous beating rate of VMs co-cultured with SNs in the presence of GDNF.	Norepinephrine	89-102	glial cell derived neurotrophic factor	Rattus norvegicus	221-225
22831878-2	2013	A functional variation in the gene coding for the catechol-O-methyltransferase (COMT) enzyme, which metabolizes dopamine and noradrenaline, has been related to executive and emotional functions, and to sex dimorphism.	Norepinephrine	125-138	catechol-O-methyltransferase	Homo sapiens	50-78
22831878-2	2013	A functional variation in the gene coding for the catechol-O-methyltransferase (COMT) enzyme, which metabolizes dopamine and noradrenaline, has been related to executive and emotional functions, and to sex dimorphism.	Norepinephrine	125-138	catechol-O-methyltransferase	Homo sapiens	80-84
23643763-1	2013	Catechol-O-methyltransferase (COMT) plays an important role in the catabolism of brain dopamine and norepinephrine, which have been implicated in the pathogenesis of Autism spectrum disorder (ASD) as well as in other neuropsychatric disorders.	Norepinephrine	100-114	catechol-O-methyltransferase	Homo sapiens	0-28
23643763-1	2013	Catechol-O-methyltransferase (COMT) plays an important role in the catabolism of brain dopamine and norepinephrine, which have been implicated in the pathogenesis of Autism spectrum disorder (ASD) as well as in other neuropsychatric disorders.	Norepinephrine	100-114	catechol-O-methyltransferase	Homo sapiens	30-34
23489141-4	2013	The effects of (-)-noradrenaline, mediated through beta1 adrenoceptors (beta2 adrenoceptors blocked with ICI118551), and (-)-adrenaline, mediated through beta2 adrenoceptors (beta1 adrenoceptors blocked with CGP20712A), were assessed in the absence and presence of PDE inhibitors.	Norepinephrine	15-32	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	154-159
23208077-7	2013	However, CAS did not alter the mRNA levels of TPH or TH, both of which are rate-limiting enzymes for the synthesis of serotonin and norepinephrine in the dorsal raphe and locus coeruleus, respectively.	Norepinephrine	132-146	tyrosine hydroxylase	Rattus norvegicus	53-55
24450388-1	2013	Catechol-O-methyltransferase (COMT) is the enzyme which catalyzes the transfer of a methyl group from S-adenosylmethionine to catechols and catecholamines, like the neurotransmitters dopamine, epinephrine and norepinephrine.	Norepinephrine	209-223	catechol-O-methyltransferase	Homo sapiens	0-28
24450388-1	2013	Catechol-O-methyltransferase (COMT) is the enzyme which catalyzes the transfer of a methyl group from S-adenosylmethionine to catechols and catecholamines, like the neurotransmitters dopamine, epinephrine and norepinephrine.	Norepinephrine	209-223	catechol-O-methyltransferase	Homo sapiens	30-34
22765285-2	2012	We have typed 2 functional polymorphisms of relevance for both biosynthesis and catabolism of noradrenalin: The Val158Met single-nucleotide polymorphism (SNP) of the Catechol-O-methyl transferase gene (COMT) and the 1021C/T SNP of the dopamine dehydroxylase gene (DBH).	Norepinephrine	94-106	catechol-O-methyltransferase	Homo sapiens	166-195
22765285-2	2012	We have typed 2 functional polymorphisms of relevance for both biosynthesis and catabolism of noradrenalin: The Val158Met single-nucleotide polymorphism (SNP) of the Catechol-O-methyl transferase gene (COMT) and the 1021C/T SNP of the dopamine dehydroxylase gene (DBH).	Norepinephrine	94-106	catechol-O-methyltransferase	Homo sapiens	202-206
22858378-0	2012	Transglutaminase-mediated transamidation of serotonin, dopamine and noradrenaline to fibronectin: evidence for a general mechanism of monoaminylation.	Norepinephrine	68-81	transglutaminase 1	Homo sapiens	0-16
22858378-4	2012	Here we show that the catecholamines dopamine (DA) and noradrenaline (NA) inhibit serotonylation of fibronectin and that DA and NA themselves can be selectively transamidated into fibronectin by TGase.	Norepinephrine	55-68	transglutaminase 1	Homo sapiens	195-200
21769100-0	2012	Organic cation transporter 2 controls brain norepinephrine and serotonin clearance and antidepressant response.	Norepinephrine	44-58	solute carrier family 22 (organic cation transporter), member 2	Mus musculus	0-28
22866043-4	2012	Limited evidence exists for positive effects of HAI on: reduction of stress-related parameters such as epinephrine and norepinephrine; improvement of immune system functioning and pain management; increased trustworthiness of and trust toward other persons; reduced aggression; enhanced empathy and improved learning.	Norepinephrine	119-133	serine peptidase inhibitor, Kunitz type 1	Homo sapiens	48-51
22582116-3	2012	In cells perfused with Ca(2+)-free Krebs Ringer bicarbonate solution (KRBS), brief exposures to caffeine (30 mM) and norepinephrine (300 muM), which activate SR ryanodine and inositol trisphosphate receptors (RyR, IP(3)R), respectively, or 4% O(2) caused rapid transient increases in [Ca(2+)](i), indicating intracellular Ca(2+) release.	Norepinephrine	117-131	ryanodine receptor 2	Rattus norvegicus	209-212
22988760-0	2012	[Involvement of calmodulin in realization of vasoconstrictive effects of serotonin and norepinephrin].	Norepinephrine	87-100	calmodulin 1	Rattus norvegicus	16-26
22483291-1	2012	One of the most important enzymes in the catecholamine cycle, catecholamine-O-methyltransferase (COMT), plays a critical role in the extracellular metabolism of dopamine and norepinephrine both in the periphery and the central nervous system.	Norepinephrine	174-188	catechol-O-methyltransferase	Homo sapiens	62-95
22483291-1	2012	One of the most important enzymes in the catecholamine cycle, catecholamine-O-methyltransferase (COMT), plays a critical role in the extracellular metabolism of dopamine and norepinephrine both in the periphery and the central nervous system.	Norepinephrine	174-188	catechol-O-methyltransferase	Homo sapiens	97-101
21702050-10	2012	(f) p38-MAPK and Tpl2 were crucial intermediates for both CRF(1) and CRF(2)-induced norepinephrine production, while AKT1 affected only CRF(2)-induced norepinephrine production.	Norepinephrine	84-98	mitogen activated protein kinase 14	Rattus norvegicus	4-7
21702050-10	2012	(f) p38-MAPK and Tpl2 were crucial intermediates for both CRF(1) and CRF(2)-induced norepinephrine production, while AKT1 affected only CRF(2)-induced norepinephrine production.	Norepinephrine	151-165	mitogen activated protein kinase 14	Rattus norvegicus	4-7
22233932-4	2012	Summit metabolism ( V O2summit) and norepinephrine-induced thermogenesis ( V O2NST) were significantly lower in UCP-dta mice relative to wild-type mice regardless of temperature treatment, but both were significantly higher in cold relative to warm acclimated mice.	Norepinephrine	36-50	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	112-115
22319800-3	2004	Vesicular monoamine transporter (VMAT2) is present in brain monoaminergic neurons and is responsible for collecting neurotransmitters (e.g., dopamine, norepinephrine, and serotonin) from the cytoplasm and storing them in vesicles for synaptic release (1).	Norepinephrine	151-165	solute carrier family 18 member A2	Homo sapiens	33-38
22149309-3	2012	The alpha(1D)-adrenoceptor antagonist, BMY-7378 (BMY) blocked noradrenaline-induced responses in the order SO &gt; AC7 &gt;&gt; AC14; in contrast, the alpha(1A)-adrenoceptor antagonist RS-100329 (RS), produced a marginal shift to the right of the dose-response curve to noradrenaline, along with a strong decrease of the maximum pressor effect in the order SO &gt; AC7 = AC14.	Norepinephrine	270-283	adrenoceptor alpha 1D	Rattus norvegicus	4-26
22899923-10	2012	The SLIT2 SNP rs1379659 and the FAM5C SNP rs1935881 were associated with norepinephrine change during exercise.	Norepinephrine	73-87	BMP/retinoic acid inducible neural specific 3	Homo sapiens	32-37
23209788-8	2012	Preincubation with either the COX-1/2 (indomethacin) or COX-2 inhibitor (NS-398) decreased noradrenaline contraction only in 6- and 12-month-old O-DR, while it remained unmodified by COX-1 inhibitor SC-560.	Norepinephrine	91-104	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	56-61
23209788-11	2012	Noradrenaline-stimulated TxB(2) and PGE(2) release was higher in 6- and 12-month-old O-DR, whereas PGF(2alpha) was increased only in 12-month-old O-DR. Our results demonstrated that in utero exposure to maternal hyperglycaemia in rats increases the participation of COX-2-derived prostanoids on contraction to noradrenaline, which might help to explain the greater response to this agonist in MRA from 6- and 12-month-old offspring.	Norepinephrine	0-13	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	266-271
21656904-14	2011	Based on our robust family-controlled and unrelated-affected analyses, we conclude that COMT is associated with CIP, possibly as a result of its role in the metabolism of dopamine and norepinephrine.	Norepinephrine	184-198	catechol-O-methyltransferase	Homo sapiens	88-92
21344643-2	2011	COMT involves in the degradation of dopamine and norepinephrin.	Norepinephrine	49-62	catechol-O-methyltransferase	Homo sapiens	0-4
21394088-0	2011	Activation of central angiotensin type 2 receptors suppresses norepinephrine excretion and blood pressure in conscious rats.	Norepinephrine	62-76	angiotensin II receptor, type 2	Rattus norvegicus	22-50
21460197-3	2011	Therefore, we hypothesize that prolonged exposure to norepinephrine (NE) and ANG II induces arteriolar inward remodeling dependent on the activation of MMPs and the production of ROS.	Norepinephrine	53-67	matrix metallopeptidase 2	Rattus norvegicus	152-156
21324360-7	2011	Nevertheless, even at advanced stages of HD, intrinsic firing properties of orexin cells remain normal and suppressible by serotonin, noradrenaline, and glucose.	Norepinephrine	134-147	hypocretin	Mus musculus	76-82
21402125-7	2011	The Met/Met genotype of COMT may have an effect on aggressive behaviour in schizophrenia because norepinephrine is less effectively inactivated.	Norepinephrine	97-111	catechol-O-methyltransferase	Homo sapiens	24-28
21317437-5	2011	Norepinephrine, acting via beta-adrenergic, cAMP-mediated, mechanisms and subsequent activation of protein kinase A and p38 MAPK, induces FGF21 gene transcription and also FGF21 release in brown adipocytes.	Norepinephrine	0-14	fibroblast growth factor 21	Rattus norvegicus	138-143
20860878-4	2011	The enzyme catechol-O-methyl transferase (COMT) degrades dopamine, epinephrine and norepinephrine.	Norepinephrine	83-97	catechol-O-methyltransferase	Homo sapiens	11-40
20860878-4	2011	The enzyme catechol-O-methyl transferase (COMT) degrades dopamine, epinephrine and norepinephrine.	Norepinephrine	83-97	catechol-O-methyltransferase	Homo sapiens	42-46
21039464-0	2011	Activation of p38 mitogen-activated protein kinase by norepinephrine in T-lineage cells.	Norepinephrine	54-68	mitogen-activated protein kinase 14	Mus musculus	14-17
21051529-5	2011	We found that norepinephrine activates the PI3K/Akt/GSK-3beta pathway to concurrently enhance alpha(1C)-protein translation and block its polyubiquitination and proteasomal degradation.	Norepinephrine	14-28	glycogen synthase kinase 3 beta	Rattus norvegicus	52-61
21051529-6	2011	Incubation of colonic muscularis externa with norepinephrine or LiCl, which inhibits GSK-3beta, enhanced p-GSK-3beta and alpha(1C)-protein time dependently.	Norepinephrine	46-60	glycogen synthase kinase 3 beta	Rattus norvegicus	85-94
21051529-6	2011	Incubation of colonic muscularis externa with norepinephrine or LiCl, which inhibits GSK-3beta, enhanced p-GSK-3beta and alpha(1C)-protein time dependently.	Norepinephrine	46-60	glycogen synthase kinase 3 beta	Rattus norvegicus	107-116
20851100-2	2011	Depending upon the dose of norepinephrine (agonist) exposure, hypertrophy and apoptosis are initiated by differential induction of two discrete constituents of the transcription factor AP-1, i.e., FosB and Fra-1.	Norepinephrine	27-41	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	185-189
20851100-2	2011	Depending upon the dose of norepinephrine (agonist) exposure, hypertrophy and apoptosis are initiated by differential induction of two discrete constituents of the transcription factor AP-1, i.e., FosB and Fra-1.	Norepinephrine	27-41	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	197-201
21971001-3	2011	In fact, while MAO-A has high affinity for serotonin and norepinephrine, MAO-B primarily serves the catabolism of 2-phenylethylamine (PEA) and contributes to the degradation of other trace amines and dopamine.	Norepinephrine	57-71	monoamine oxidase A	Mus musculus	15-20
21098982-5	2011	We report that Ts65Dn mice exhibit progressive loss of norepinephrine (NE) phenotype in LC neurons.	Norepinephrine	55-69	reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65	Mus musculus	15-21
21154325-1	2010	The enzyme catechol-O-methyltransferase (COMT) transfers a methyl group from S-adenosylmethionine to the benzene ring of catecholamines including the neurotransmitters dopamine, epinephrine and norepinephrine.	Norepinephrine	194-208	catechol-O-methyltransferase	Homo sapiens	11-39
21154325-1	2010	The enzyme catechol-O-methyltransferase (COMT) transfers a methyl group from S-adenosylmethionine to the benzene ring of catecholamines including the neurotransmitters dopamine, epinephrine and norepinephrine.	Norepinephrine	194-208	catechol-O-methyltransferase	Homo sapiens	41-45
20641794-0	2004	2-Hydroxy-3-isobutyl-9-[(11)C]methoxy-10-methoxy-1,2,3,4,6,7,-hexahydro-11bH-bezo[alpha]-quinolizine Vesicular monoamine transporter (VMAT2) is present in brain monoaminergic neurons and is responsible for collecting neurotransmitters (dopamine, norepinephrine and serotonin) from the cytoplasm and storing them in vesicles for synaptic release (1).	Norepinephrine	246-260	solute carrier family 18 member A2	Homo sapiens	134-139
20510373-1	2010	The functional Val158Met polymorphism in the gene coding for the catechol-O-methyltransferase (COMT), the major enzyme degrading the catecholaminergic neurotransmitters dopamine, norepinephrine, and epinephrine, has been associated with differential reactivity in limbic and prefrontal brain areas in response to aversive stimuli.	Norepinephrine	179-193	catechol-O-methyltransferase	Homo sapiens	65-93
20510373-1	2010	The functional Val158Met polymorphism in the gene coding for the catechol-O-methyltransferase (COMT), the major enzyme degrading the catecholaminergic neurotransmitters dopamine, norepinephrine, and epinephrine, has been associated with differential reactivity in limbic and prefrontal brain areas in response to aversive stimuli.	Norepinephrine	179-193	catechol-O-methyltransferase	Homo sapiens	95-99
20650306-0	2010	Calcitonin gene related peptide (CGRP) inhibits norepinephrine induced apoptosis in cultured rat cardiomyocytes not via PKA or PKC pathways.	Norepinephrine	48-62	calcitonin-related polypeptide alpha	Rattus norvegicus	0-31
20650306-0	2010	Calcitonin gene related peptide (CGRP) inhibits norepinephrine induced apoptosis in cultured rat cardiomyocytes not via PKA or PKC pathways.	Norepinephrine	48-62	calcitonin-related polypeptide alpha	Rattus norvegicus	33-37
20650306-2	2010	Calcitonin gene related peptide and norepinephrine could be simultaneously up-regulated in early time of acute myocardial ischemia, suggesting a co-participation of calcitonin gene related peptide and norepinephrine in the pathology.	Norepinephrine	36-50	calcitonin-related polypeptide alpha	Rattus norvegicus	165-196
20650306-2	2010	Calcitonin gene related peptide and norepinephrine could be simultaneously up-regulated in early time of acute myocardial ischemia, suggesting a co-participation of calcitonin gene related peptide and norepinephrine in the pathology.	Norepinephrine	201-215	calcitonin-related polypeptide alpha	Rattus norvegicus	0-31
20650306-3	2010	In this study, we investigated a potential anti-apoptotic effect of calcitonin gene related peptide on myocardial apoptosis induced by norepinephrine and its link with the protein kinase A (PKA) or protein kinase C (PKC) pathway in cultured neonatal rat cardiomyocytes.	Norepinephrine	135-149	calcitonin-related polypeptide alpha	Rattus norvegicus	68-99
20650306-7	2010	The pro-apoptotic effect of norepinephrine was attenuated by H89 (3 x 10(-5)mol/l) or by calcitonin gene related peptide which could be completely reversed by CGRP(8-37).	Norepinephrine	28-42	calcitonin-related polypeptide alpha	Rattus norvegicus	89-120
20650306-7	2010	The pro-apoptotic effect of norepinephrine was attenuated by H89 (3 x 10(-5)mol/l) or by calcitonin gene related peptide which could be completely reversed by CGRP(8-37).	Norepinephrine	28-42	calcitonin-related polypeptide alpha	Rattus norvegicus	159-163
20650306-9	2010	Calcitonin gene related peptide inhibits norepinephrine induced apoptosis in cultured cardiomyocytes, which is mediated by CGRP receptor but unlikely to be mediated by PKA or PKC pathway.	Norepinephrine	41-55	calcitonin-related polypeptide alpha	Rattus norvegicus	0-31
20650306-9	2010	Calcitonin gene related peptide inhibits norepinephrine induced apoptosis in cultured cardiomyocytes, which is mediated by CGRP receptor but unlikely to be mediated by PKA or PKC pathway.	Norepinephrine	41-55	calcitonin-related polypeptide alpha	Rattus norvegicus	123-127
20434498-4	2010	In various densities, networks of orexin-positive fibers and terminals were present on neurons of each adrenaline (C1, C2, C3) and noradrenaline (locus coeruleus, A1, A2, A4, A5 and A7) cell groups.	Norepinephrine	131-144	hypocretin neuropeptide precursor	Homo sapiens	34-40
20406628-0	2010	Combined treatment with MAO-A inhibitor and MAO-B inhibitor increases extracellular noradrenaline levels more than MAO-A inhibitor alone through increases in beta-phenylethylamine.	Norepinephrine	84-97	monoamine oxidase A	Rattus norvegicus	24-29
20406628-11	2010	Our results suggest that the combined treatment with a MAO-A inhibitor and a MAO-B inhibitor strengthens antidepressant effects because the combined treatment increases extracellular noradrenaline levels more than a MAO-A inhibitor alone through increases in beta-phenylethylamine.	Norepinephrine	183-196	monoamine oxidase A	Rattus norvegicus	55-60
20170659-7	2010	Short interfering RNA targeting XBP1 suppressed the induction of BNP expression by a pharmacological ER stressor or norepinephrine, which was rescued by the adenovirus-mediated overexpression of sXBP1.	Norepinephrine	116-130	natriuretic peptide B	Homo sapiens	65-68
20170659-8	2010	The promoter assay with overexpression of sXBP1 or norepinephrine showed that the proximal AP1/CRE-like element in the promoter region of BNP was critical for transcriptional regulation of BNP by sXBP1.	Norepinephrine	51-65	natriuretic peptide B	Homo sapiens	138-141
20170659-8	2010	The promoter assay with overexpression of sXBP1 or norepinephrine showed that the proximal AP1/CRE-like element in the promoter region of BNP was critical for transcriptional regulation of BNP by sXBP1.	Norepinephrine	51-65	natriuretic peptide B	Homo sapiens	189-192
20036647-0	2010	Leptin modulates noradrenaline release in the paraventricular nucleus and plasma oxytocin levels in female rats: a microdialysis study.	Norepinephrine	17-30	leptin	Rattus norvegicus	0-6
20036647-3	2010	The main hypothesis was that leptin has an inhibitory action on oxytocin secretion and hypothalamic release of noradrenaline.	Norepinephrine	111-124	leptin	Rattus norvegicus	29-35
20036647-8	2010	Central administration of leptin significantly reduced both plasma oxytocin and hypothalamic noradrenaline responses to CCK at 20 min following the treatments.	Norepinephrine	93-106	leptin	Rattus norvegicus	26-32
20036647-10	2010	The modulator effect of leptin on noradrenaline release in the PVN may be related to feeding behavior.	Norepinephrine	34-47	leptin	Rattus norvegicus	24-30
19931319-5	2010	Ghrelin administered intravenously suppressed noradrenaline release in the BAT of WT rats, but not in Tg rats.	Norepinephrine	46-59	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
19931319-7	2010	As our previous study showed that peripheral ghrelin-induced noradrenaline release suppression in BAT is blocked by vagotomy, the present findings also suggest that vagal afferents transmit the peripheral ghrelin signal to the sympathetic nervous system innervating BAT.	Norepinephrine	61-74	ghrelin and obestatin prepropeptide	Rattus norvegicus	45-52
19931319-7	2010	As our previous study showed that peripheral ghrelin-induced noradrenaline release suppression in BAT is blocked by vagotomy, the present findings also suggest that vagal afferents transmit the peripheral ghrelin signal to the sympathetic nervous system innervating BAT.	Norepinephrine	61-74	ghrelin and obestatin prepropeptide	Rattus norvegicus	205-212
20525314-0	2010	Tumor necrosis factor and norepinephrine lower the levels of human neutrophil peptides 1-3 secretion by mixed synovial tissue cultures in osteoarthritis and rheumatoid arthritis.	Norepinephrine	26-40	defensin alpha 3	Homo sapiens	67-90
19748568-7	2010	Additionally, norepinephrine significantly reduced IgA alpha-chain mRNA levels but increased pIgR mRNA expression and IgA concentration in both intestinal segments.	Norepinephrine	14-28	polymeric immunoglobulin receptor	Rattus norvegicus	93-97
20235428-0	2010	[Agonist 5HT1A-receptors of serotonin 8-OH-DPAT increase the power of collapse of the aorta and mesenteric artery in rats in the presence of endothelin-1 or vasopressin and cause vessel relaxation precollapsing with noradrenaline].	Norepinephrine	216-229	5-hydroxytryptamine receptor 1A	Rattus norvegicus	9-14
20235428-1	2010	Agonist 5HT1A serotonin receptors 8-OH-DPAT at 70-80% in rats relax the isolated aorta and mesenteric artery, precollapsed with noradrenaline.	Norepinephrine	128-141	5-hydroxytryptamine receptor 1A	Rattus norvegicus	8-13
19968887-4	2009	RESULTS: The activation of naive CD8+ T lymphocytes by CD3/CD28 cross-linking was inhibited by norepinephrine and dopamine, which was caused by a downregulation of interleukin (IL)-2 expression via Erk1/2 and NF-kappaB inhibition.	Norepinephrine	95-109	CD28 molecule	Homo sapiens	59-63
19259685-8	2009	CONCLUSIONS: Our results demonstrate that in mouse ureters: the mRNA for the alpha1A-adrenoceptor was more prevalent than those for the alpha1B- and alpha1D-adrenoceptors, and that among these subtypes, the alpha1A-adrenoceptor plays the major role in noradrenaline-induced contraction.	Norepinephrine	252-265	adrenergic receptor, alpha 1a	Mus musculus	77-97
19783781-0	2009	Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits.	Norepinephrine	22-36	cytochrome c oxidase subunit II	Oryctolagus cuniculus	45-50
19783781-10	2009	These observations suggest that the local induction of COX-2 during atherosclerosis decreased the sensitivity to norepinephrine and that COX-2 inhibitors may increase vascular reactivity at sites of atherosclerotic lesions.	Norepinephrine	113-127	cytochrome c oxidase subunit II	Oryctolagus cuniculus	55-60
19695215-8	2009	Norepinephrine also induced phosphorylation of ERK1/2, which was prevented by staurosporine treatment.	Norepinephrine	0-14	mitogen activated protein kinase 3	Rattus norvegicus	47-53
19695215-10	2009	These findings indicate that norepinephrine stimulates DNA synthesis via alpha1-adrenergic receptors and downstream Ca(2+)/PKC and ERK1/2 activation in rBMSCs.	Norepinephrine	29-43	mitogen activated protein kinase 3	Rattus norvegicus	131-137
19394424-0	2009	Contractile response of norepinephrine is modulated by caspase-3 in adult rat ventricular myocytes isolated from septic rat heart.	Norepinephrine	24-38	caspase 3	Rattus norvegicus	55-64
19690620-1	2009	BACKGROUND: Candidate genes of psychological importance include 5HT2A, 5HT2C, and COMT, implicated in the serotonin, noradrenaline and dopamine pathways, which also may be involved in regulation of energy balance.	Norepinephrine	117-130	catechol-O-methyltransferase	Homo sapiens	82-86
19547755-2	2009	The functional polymorphism (val(158)met) of the Catechol-O-methyltransferase (COMT) gene regulates the metabolism of dopamine/noradrenaline.	Norepinephrine	127-140	catechol-O-methyltransferase	Homo sapiens	49-77
19547755-2	2009	The functional polymorphism (val(158)met) of the Catechol-O-methyltransferase (COMT) gene regulates the metabolism of dopamine/noradrenaline.	Norepinephrine	127-140	catechol-O-methyltransferase	Homo sapiens	79-83
19443836-10	2009	Essentially the same results were obtained for TRPC6-like cation channel in A7r5 myocytes, where its activation by noradrenaline or Arg8 vasopressin was greatly enhanced by mechanical stimuli via 20-HETE production.	Norepinephrine	115-128	transient receptor potential cation channel subfamily C member 6	Homo sapiens	47-52
19359422-3	2009	We tested the hypothesis that heterotypic chronic stress (HeCS) elevates the release of norepinephrine from the adrenal medulla, which enhances transcription of the gene-regulating expression of Ca(v)1.2 (L-type) channels in colonic circular smooth muscle cells, resulting in enhanced colonic motor function.	Norepinephrine	88-102	immunoglobulin lambda variable 2-8	Homo sapiens	195-203
19489787-6	2009	Further results of Western blotting found that the protein expression of tyrosine hydroxylase and synapsin I (especially its active form, synapsin I phosphoSer603) was also down-regulated, which were directly related to synthesis and release of norepinephrine, respectively.	Norepinephrine	245-259	tyrosine hydroxylase	Rattus norvegicus	73-93
19489787-7	2009	All the results suggest that Y-27632 is able to down-regulate norepinephrine synthesis and release, the direct mechanism of which may be associated with down-regulation on expression of some proteins, including tyrosine hydroxylase and synapsin I.	Norepinephrine	62-76	tyrosine hydroxylase	Rattus norvegicus	211-231
19351665-5	2009	administered ghrelin (30 nmol) suppressed noradrenaline release in BAT, and this suppression was blocked by a vagotomy.	Norepinephrine	42-55	ghrelin and obestatin prepropeptide	Rattus norvegicus	13-20
19351665-8	2009	administration of des-acyl ghrelin, which does not bind to GH secretagogue receptor type 1a (GHS-R1a), affected noradrenaline release in BAT.	Norepinephrine	112-125	ghrelin and obestatin prepropeptide	Rattus norvegicus	27-34
19364979-6	2009	Similarly, vascular smooth muscle cell-selective PPARgamma knockout mice display a biphasic response to norepinephrine in BP, reversible on administration of beta-AdR blocker, and enhanced BP reduction on treatment with beta-AdR agonists.	Norepinephrine	104-118	peroxisome proliferator activated receptor gamma	Mus musculus	49-58
19187776-3	2009	In wild-type mice, high-fat diet increased norepinephrine-induced thermogenesis; i.e., diet-induced thermogenesis was observed, but no such effect was observed in UCP1-ablated mice, demonstrating that diet-induced thermogenesis fully emanates from UCP1 activity.	Norepinephrine	43-57	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	248-252
18628210-11	2008	The plasma epinephrine and norepinephrine levels in the beta3-Tg mice were significantly increased in the basal state, indicating enhanced sympathetic tone.	Norepinephrine	27-41	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	56-61
18574452-4	2008	They have shown that in mice lacking the functional alpha1A-adrenoceptor gene, alpha1L-mediated responses to noradrenaline in prostate smooth muscle are substantially attenuated.	Norepinephrine	109-122	adrenergic receptor, alpha 1a	Mus musculus	52-72
18670185-6	2008	Zingerone significantly increased norepinephrine-induced lipolysis associated with the translocation of hormone-sensitive lipase (HSL) from the cytosol to lipid droplets in adipocytes.	Norepinephrine	34-48	lipase E, hormone sensitive type	Rattus norvegicus	104-128
18670185-6	2008	Zingerone significantly increased norepinephrine-induced lipolysis associated with the translocation of hormone-sensitive lipase (HSL) from the cytosol to lipid droplets in adipocytes.	Norepinephrine	34-48	lipase E, hormone sensitive type	Rattus norvegicus	130-133
18585703-3	2008	Evidences have demonstrated that berberine possesses central nervous system activities, particularly the ability to inhibit monoamine oxidase-A, an enzyme involved in the degradation of norepinephrine and serotonin (5-HT).	Norepinephrine	186-200	monoamine oxidase A	Mus musculus	124-143
18329096-2	2008	NPY containing neurons have a broad central distribution and are often colocalized with norepinephrine (NE).	Norepinephrine	88-102	neuropeptide Y	Mus musculus	0-3
18177483-13	2008	We conclude that noradrenaline-induced increases in the expression of NHE-3, NBC-1, BSC-1 and aquaporin-2 are likely to play an important role in the regulation of salt and water transport by noradrenaline in the kidney and may explain, at least in part, the altered renal sodium and water handling associated with overactivation of the sympathetic system.	Norepinephrine	192-205	solute carrier family 9 member A3	Rattus norvegicus	70-75
18258664-6	2008	The KCl-induced increase in TH expression was partly reduced in the presence of the nicotinic receptor antagonist hexamethonium (100 microm), of noradrenaline (1 microm) and of the alpha(2)-adrenoreceptor agonist clonidine (1 microm).	Norepinephrine	145-158	tyrosine hydroxylase	Rattus norvegicus	28-30
17664042-8	2008	These results also provide evidence that activation of NTR1 in the RVM produces antinociception through spinal release of norepinephrine (NE) and serotonin, and that activation of NTR2 in the RVM produces antinociception mediated by spinal release of NE.	Norepinephrine	122-136	neurotensin receptor 1	Homo sapiens	55-59
18364034-0	2008	Matrix metalloproteinases MMP2 and MMP9 are upregulated by noradrenaline in the mouse neuroendocrine hypothalamus.	Norepinephrine	59-72	matrix metallopeptidase 9	Mus musculus	35-39
18364034-5	2008	We investigated the possible regulation of the two gelatinases, MMP2 and MMP9, by noradrenaline (NA) in the mouse neuroendocrine hypothalamus.	Norepinephrine	82-95	matrix metallopeptidase 9	Mus musculus	73-77
18023073-2	2008	The purpose of the present study was to determine whether the tyrosine hydroxylase (TH) val81met and catechol-O-methyltransferase (COMT) val158met polymorphisms are associated with the antidepressant effect of milnacipran, a serotonin/noradrenaline reuptake inhibitor.	Norepinephrine	235-248	catechol-O-methyltransferase	Homo sapiens	131-135
18162482-5	2008	This conductance is modulated by norepinephrine, acting on alpha 1-adrenergic receptors, and serotonin, acting on 5-HT2 receptors.	Norepinephrine	33-47	5-hydroxytryptamine receptor 2A	Rattus norvegicus	114-119
18086951-9	2008	Overexpression of AT(2)R in the RVLM also significantly decreased the urine concentration of noradrenaline and 24-hour noradrenaline excretion (1.1+/-0.5 microg in control rats and 2.4+/-0.5 microg in AT(2)R rats; P&lt;0.05).	Norepinephrine	93-106	angiotensin II receptor, type 2	Rattus norvegicus	18-24
18086951-9	2008	Overexpression of AT(2)R in the RVLM also significantly decreased the urine concentration of noradrenaline and 24-hour noradrenaline excretion (1.1+/-0.5 microg in control rats and 2.4+/-0.5 microg in AT(2)R rats; P&lt;0.05).	Norepinephrine	119-132	angiotensin II receptor, type 2	Rattus norvegicus	18-24
18032527-12	2008	NPY and TH in vascular sympathetic nerves are likely to modulate NPY and/or norepinephrine release from these nerves and are thus likely to affect blood flow and blood pressure.	Norepinephrine	76-90	tyrosine hydroxylase	Rattus norvegicus	8-10
17853069-3	2008	Also, in the adrenal glands basal levels of tyrosine hydroxylase protein, the rate-limiting enzyme for catecholamine biosynthesis, and of phenylethanolamine N-methyltransferase, which converts norepinephrine to epinephrine, were significantly reduced in nNOS KO mice.	Norepinephrine	193-207	nitric oxide synthase 1, neuronal	Mus musculus	254-258
17994288-3	2007	We found that norepinephrine had an inhibitory function on the fMLP-promoted adhesion of neutrophil granulocytes due to a down-regulation of beta2-integrin.	Norepinephrine	14-28	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	141-146
17766642-1	2007	Monoamines, such as serotonin, dopamine, and norepinephrine, are sequestered into synaptic vesicles by specific transporters (vesicular monoamine transporter-2; VMAT2) using energy from an electrochemical proton gradient across the vesicle membranes.	Norepinephrine	45-59	solute carrier family 18 member A2	Homo sapiens	126-159
17766642-1	2007	Monoamines, such as serotonin, dopamine, and norepinephrine, are sequestered into synaptic vesicles by specific transporters (vesicular monoamine transporter-2; VMAT2) using energy from an electrochemical proton gradient across the vesicle membranes.	Norepinephrine	45-59	solute carrier family 18 member A2	Homo sapiens	161-166
19300629-1	2007	A functional polymorphism of the gene coding for Catechol-O-methyltrasferase (COMT), an enzyme responsible for the degradation of the catecholamine dopamine (DA), epinephrine, and norepinephrine, is associated with cognitive deficits.	Norepinephrine	180-194	catechol-O-methyltransferase	Homo sapiens	49-76
19300629-1	2007	A functional polymorphism of the gene coding for Catechol-O-methyltrasferase (COMT), an enzyme responsible for the degradation of the catecholamine dopamine (DA), epinephrine, and norepinephrine, is associated with cognitive deficits.	Norepinephrine	180-194	catechol-O-methyltransferase	Homo sapiens	78-82
17974982-7	2007	Regarding the effects of STAT3 activation, exposure to norepinephrine resulted in an increase in invasion and matrix metalloproteinase (MMP-2 and MMP-9) production.	Norepinephrine	55-69	matrix metallopeptidase 9	Mus musculus	146-151
17482290-0	2007	Elevated renal norepinephrine in proANP gene-disrupted mice is associated with increased tyrosine hydroxylase expression in sympathetic ganglia.	Norepinephrine	15-29	tyrosine hydroxylase	Mus musculus	89-109
17573135-10	2007	Adrenaline, noradrenaline, endothelin and secretin stimulated ghrelin release, while somatostatin and GRP inhibited.	Norepinephrine	12-25	ghrelin and obestatin prepropeptide	Rattus norvegicus	62-69
17689499-0	2007	Upregulation of sodium-dependent vitamin C transporter 2 expression in adrenals increases norepinephrine production and aggravates hyperlipidemia in mice with streptozotocin-induced diabetes.	Norepinephrine	90-104	solute carrier family 23 (nucleobase transporters), member 2	Mus musculus	16-56
17689499-6	2007	Furthermore, increased AA incorporation into the diabetic adrenals by SVCT-2 led to increased plasma norepinephrine, triglyceride and free fatty acid levels in mice with STZ-induced diabetes.	Norepinephrine	101-115	solute carrier family 23 (nucleobase transporters), member 2	Mus musculus	70-76
17689499-7	2007	Therefore, oversupplementation with AA could be deleterious in diabetic patients, because overexpression of adrenal SVCT-2 in diabetes could lead to excessive AA uptake, thus enhancing norepinephrine production and exacerbating some diabetic complications.	Norepinephrine	185-199	solute carrier family 23 member 2	Homo sapiens	116-122
17689499-9	2007	These results suggest SVCT-2-mediated increases in AA uptake by the adrenals followed by excessive production of plasma norepinephrine may play a pivotal role in the development of diabetic complications.	Norepinephrine	120-134	solute carrier family 23 (nucleobase transporters), member 2	Mus musculus	22-28
17628524-2	2007	administered histamine evokes the secretion of noradrenaline and adrenaline from adrenal medulla by brain cyclooxygenase-1- and thromboxane A2-mediated mechanisms in rats.	Norepinephrine	47-60	prostaglandin-endoperoxide synthase 1	Rattus norvegicus	106-122
17446180-2	2007	Treatment of pinealocytes with norepinephrine (NE) caused an increase in the mRNA level of Dio2 that peaked around 2 h and declined over the next 5 h. Both beta- and alpha1-adrenergic receptors contributed to the NE induction of Dio2 expression through a cAMP/protein kinase A mechanism.	Norepinephrine	31-45	iodothyronine deiodinase 2	Rattus norvegicus	91-95
17446180-2	2007	Treatment of pinealocytes with norepinephrine (NE) caused an increase in the mRNA level of Dio2 that peaked around 2 h and declined over the next 5 h. Both beta- and alpha1-adrenergic receptors contributed to the NE induction of Dio2 expression through a cAMP/protein kinase A mechanism.	Norepinephrine	31-45	iodothyronine deiodinase 2	Rattus norvegicus	229-233
17502491-5	2007	Interestingly, norepinephrine-dependent blood pressure elevations were conserved in NOX1-deficient mice, demonstrating that, different from angiotensin II, it acts through NOX1-independent hypertensive mechanisms.	Norepinephrine	15-29	NADPH oxidase 1	Mus musculus	84-88
17591129-5	2007	Preoperative NT-pro BNP levels correlated with ventilation time (r = 0.46), length of stay in intensive care unit (r = 0.59), total perioperative noradrenaline dose (r = 0.55), but not with postoperative atrial fibrillation or mortality.	Norepinephrine	146-159	natriuretic peptide B	Homo sapiens	20-23
17591129-6	2007	Using multivariate analysis, serum NT-pro BNP levels at 36 hours were associated with increased noradrenaline dose (P = 0.001), decreased preoperative ejection fraction (EF) Group (P = 0.013) and elevated preoperative NT-pro BNP (P &lt; 0.001).	Norepinephrine	96-109	natriuretic peptide B	Homo sapiens	42-45
17383824-1	2007	The effect of neuropeptide Y (NPY), a co-transmitter with noradrenaline in peripheral sympathetic nerve fibers, on the osteoclastogenesis in mouse bone marrow cell cultures treated with isoprenaline, a beta-adrenergic receptor (beta-AR) agonist, was examined.	Norepinephrine	58-71	neuropeptide Y	Mus musculus	30-33
17547583-4	2007	The catechol-O-methyl transferase (COMT) gene is located on chromosome 22q11 and is involved in the metabolism of dopamine and norepinephrine.	Norepinephrine	127-141	catechol-O-methyltransferase	Homo sapiens	4-33
17547583-4	2007	The catechol-O-methyl transferase (COMT) gene is located on chromosome 22q11 and is involved in the metabolism of dopamine and norepinephrine.	Norepinephrine	127-141	catechol-O-methyltransferase	Homo sapiens	35-39
17526059-4	2007	COMT enzyme inactivates dopamine and noradrenaline.	Norepinephrine	37-50	catechol-O-methyltransferase	Homo sapiens	0-4
17457889-1	2007	Catecholamines (dopamine, norepinephrine, and epinephrine) are all synthesized from a common pathway in which tyrosine hydroxylase (TH) is the rate-limiting enzyme.	Norepinephrine	26-40	tyrosine hydroxylase	Mus musculus	110-130
17457889-1	2007	Catecholamines (dopamine, norepinephrine, and epinephrine) are all synthesized from a common pathway in which tyrosine hydroxylase (TH) is the rate-limiting enzyme.	Norepinephrine	26-40	tyrosine hydroxylase	Mus musculus	132-134
17419751-4	2007	Within the microtubule-associated protein and tyrosine hydroxylase (TH)-positive cell population adenosine triphosphate, noradrenaline, acetylcholine and L-glutamate elicited positive elevations of Ca2+ in 74, 66, 58 and 67% of the population; cells could be further subdivided into three major pharmacologically distinct populations based on the combinations of agonist they responded to.	Norepinephrine	121-134	tyrosine hydroxylase	Mus musculus	46-66
17405690-9	2007	Mercury, cadmium, and other heavy metals inactivate COMT, which increases serum and urinary epinephrine, norepinephrine, and dopamine.	Norepinephrine	105-119	catechol-O-methyltransferase	Homo sapiens	52-56
17222943-1	2007	The vasoconstrictor neuropeptide Y (NPY) has been shown to down-regulate tyrosine hydroxylase expression in cultured adrenal chromaffin cells, which probably accounts for the higher plasma resting norepinephrine (NE) and epinephrine (E) concentrations observed in Y(1) knock-out mice (Y(1)-/-) than in wild-type mice (Y(1)+/+).	Norepinephrine	197-211	neuropeptide Y	Mus musculus	20-34
17041759-1	2006	Our previous study demonstrated that norepinephrine (NE) induces endothelial apoptosis mainly through down-regulation of Bcl-2 protein and activation of the beta-adrenergic and caspase-2 pathways.	Norepinephrine	37-51	caspase 2	Rattus norvegicus	177-186
17079456-0	2006	Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells.	Norepinephrine	0-14	matrix metallopeptidase 2	Homo sapiens	82-114
17079456-2	2006	The purpose of this study is to determine if the stress hormone norepi can influence the expression of MMP-2, MMP-9, and VEGF in nasopharyngeal carcinoma (NPC) tumors by using three NPC tumor cell lines.	Norepinephrine	64-70	matrix metallopeptidase 2	Homo sapiens	103-108
17228090-4	2006	It is likely that despite of higher concentration of noradrenaline (which inhibits leptin gene expression in WAT) in old animals, the age-dependent decrease of beta-adrenergic receptor density in rat adipocytes may lead to the increase of leptin gene expression and to the increase of WAT leptin concentration.	Norepinephrine	53-66	leptin	Rattus norvegicus	83-89
16968473-5	2006	4 The alpha(1D)-adrenoceptor-selective antagonist 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4,5]decane-7,9-dione (BMY7378) caused rightward shifts of the concentration-response curves to noradrenaline, yielding a low affinity estimate (6.6) for the urethral receptor.	Norepinephrine	203-216	alpha-1D adrenergic receptor	Sus scrofa	6-28
16940168-3	2006	t-PA inhibition markedly reduced contraction of the guinea pig vas deferens to electrical field stimulation (EFS) and norepinephrine (NE) exocytosis from cardiac synaptosomes.	Norepinephrine	118-132	plasminogen activator, tissue	Mus musculus	0-4
16920928-0	2006	The level of IgE produced by a B cell is regulated by norepinephrine in a p38 MAPK- and CD23-dependent manner.	Norepinephrine	54-68	mitogen-activated protein kinase 14	Mus musculus	74-82
16920928-0	2006	The level of IgE produced by a B cell is regulated by norepinephrine in a p38 MAPK- and CD23-dependent manner.	Norepinephrine	54-68	Fc receptor, IgE, low affinity II, alpha polypeptide	Mus musculus	88-92
16772520-11	2006	Because sympathetic CB1 signaling inhibits norepinephrine (NE) release in peripheral tissues, part of the endocannabinoid activity in bone may be attributed to the regulation of NE release from sympathetic nerve fibers.	Norepinephrine	43-57	cannabinoid receptor 1 (brain)	Mus musculus	20-23
16822496-7	2006	Noradrenaline-induced contractions were competitively blocked by the selective alpha(1A)-adrenoceptor antagonists WB 4101 (pA(2)=8.88), phentolamine (pA(2)=8.39) and by the alpha(1B)-adrenoceptor antagonist spiperone (pA(2)=8.57), indicating the presence of functional alpha(1A)- and alpha(1B)-adrenoceptors.	Norepinephrine	0-13	adrenoceptor alpha 1A	Rattus norvegicus	79-101
16822496-7	2006	Noradrenaline-induced contractions were competitively blocked by the selective alpha(1A)-adrenoceptor antagonists WB 4101 (pA(2)=8.88), phentolamine (pA(2)=8.39) and by the alpha(1B)-adrenoceptor antagonist spiperone (pA(2)=8.57), indicating the presence of functional alpha(1A)- and alpha(1B)-adrenoceptors.	Norepinephrine	0-13	adrenoceptor alpha 1B	Rattus norvegicus	173-195
17102092-1	2006	Pheochromocytomas in multiple endocrine neoplasia type 2 (MEN-2) express phenylethanolamine N-methyltransferase (PNMT), the enzyme that catalyzes conversion of norepinephrine to epinephrine, whereas those in von Hippel-Lindau (VHL) syndrome do not.	Norepinephrine	160-174	phenylethanolamine N-methyltransferase	Homo sapiens	73-111
17102092-1	2006	Pheochromocytomas in multiple endocrine neoplasia type 2 (MEN-2) express phenylethanolamine N-methyltransferase (PNMT), the enzyme that catalyzes conversion of norepinephrine to epinephrine, whereas those in von Hippel-Lindau (VHL) syndrome do not.	Norepinephrine	160-174	phenylethanolamine N-methyltransferase	Homo sapiens	113-117
16611835-1	2006	We reported elsewhere that orexin neurons are directly hyperpolarized by noradrenaline (NA) and dopamine.	Norepinephrine	73-86	hypocretin	Mus musculus	27-33
16725119-2	2006	Norepinephrine is degraded by monoamine oxidase A (MAOA) and catechol-O-methyl transferase (COMT).	Norepinephrine	0-14	catechol-O-methyltransferase	Homo sapiens	61-90
16725119-2	2006	Norepinephrine is degraded by monoamine oxidase A (MAOA) and catechol-O-methyl transferase (COMT).	Norepinephrine	0-14	catechol-O-methyltransferase	Homo sapiens	92-96
16309934-10	2006	In hypertrophied NNVM induced by norepinephrine, SNAP-mediated peroxynitrite-dependent inhibition of DNA synthesis, ERK1/2 and p38 phosphorylation were significantly attenuated.	Norepinephrine	33-47	mitogen activated protein kinase 3	Rattus norvegicus	116-122
16309934-10	2006	In hypertrophied NNVM induced by norepinephrine, SNAP-mediated peroxynitrite-dependent inhibition of DNA synthesis, ERK1/2 and p38 phosphorylation were significantly attenuated.	Norepinephrine	33-47	mitogen activated protein kinase 14	Rattus norvegicus	127-130
16597439-3	2006	Insulin produced dose-dependent (10(-10)-10(-5) M) relaxation of the norepinephrine-precontracted strips of cavernosum, and of Bay K8644 [methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-2(trifluoromethylphenyl)pyridine-5-carboxylate]-precontracted strips.	Norepinephrine	69-83	insulin	Oryctolagus cuniculus	0-7
16424367-10	2006	This demonstrates a neurogenic component in the maintenance of this phenotype, which is further supported by an increase of urinary norepinephrine and epinephrine excretion in Kcc3(-/-) mice.	Norepinephrine	132-146	solute carrier family 12, member 6	Mus musculus	176-180
16490344-1	2006	Monoamine oxidase (MAO) regulates levels of dopamine, serotonin, and noradrenaline in the nervous tissue and is required for proper neuronal development.	Norepinephrine	69-82	monoamine oxidase A	Rattus norvegicus	0-17
16490344-1	2006	Monoamine oxidase (MAO) regulates levels of dopamine, serotonin, and noradrenaline in the nervous tissue and is required for proper neuronal development.	Norepinephrine	69-82	monoamine oxidase A	Rattus norvegicus	19-22
16648777-1	2006	OBJECTIVES: The catechol-O-methyltransferase (COMT) is an enzyme involved in the metabolism of dopamine, adrenaline and noradrenaline.	Norepinephrine	120-133	catechol-O-methyltransferase	Homo sapiens	16-44
16648777-1	2006	OBJECTIVES: The catechol-O-methyltransferase (COMT) is an enzyme involved in the metabolism of dopamine, adrenaline and noradrenaline.	Norepinephrine	120-133	catechol-O-methyltransferase	Homo sapiens	46-50
16543734-6	2006	However, the visceral depot of women showed a higher maximal stimulation by noradrenaline than that of men, in accordance with higher beta1- and beta3-AR protein levels.	Norepinephrine	76-89	adrenoceptor beta 1	Homo sapiens	134-153
17201629-5	2006	Knowledge about thermogenesis-induced weight loss produced by green tea"s epigallocatechin gallate and its ability to inhibit catechol-O-methyltransferase is important for health benefits and for prolonging the action of norepinephrine in the synaptic cleft.	Norepinephrine	221-235	catechol-O-methyltransferase	Homo sapiens	126-154
17447419-2	2006	), an endogenous MAO inhibitor, significantly increased norepinephrine and 5-hydroxytryptamine concentrations in the rat brain and also significantly increased acetylcholine and dopamine (DA) levels in the rat striatum.	Norepinephrine	56-70	monoamine oxidase A	Rattus norvegicus	17-20
16506409-4	2006	This they do by acting on naturally expressed prejunctional neuronal CB1 receptors to inhibit release of the contractile neurotransmitters, noradrenaline and ATP, that is provoked by the electrical stimulation.	Norepinephrine	140-153	cannabinoid receptor 1 (brain)	Mus musculus	69-72
16277617-1	2005	Phenylethanolamine N-methyltransferase (PNMT, EC2.1.1.28) catalyzes the N-methylation of norepinephrine to form epinephrine.	Norepinephrine	89-103	phenylethanolamine N-methyltransferase	Homo sapiens	0-38
16277617-1	2005	Phenylethanolamine N-methyltransferase (PNMT, EC2.1.1.28) catalyzes the N-methylation of norepinephrine to form epinephrine.	Norepinephrine	89-103	phenylethanolamine N-methyltransferase	Homo sapiens	40-44
16277617-7	2005	These observations raise the possibility of inherited variation in the ability to form epinephrine from norepinephrine as a result of variant PNMT polymorphisms and haplotypes.	Norepinephrine	104-118	phenylethanolamine N-methyltransferase	Homo sapiens	142-146
16366508-4	2005	Increase norepinephrine concentration secondary to decreased activity of monoamine oxidase A (MAOA) in hippocampus was observed in this model rats.	Norepinephrine	9-23	monoamine oxidase A	Rattus norvegicus	94-98
16156742-1	2005	The homeodomain protein Arix/Phox2a plays a role in the development and maintenance of the noradrenergic cell type by regulating the transcription of genes involved in the biosynthesis and metabolism of noradrenaline.	Norepinephrine	203-216	paired like homeobox 2A	Homo sapiens	24-28
16156742-1	2005	The homeodomain protein Arix/Phox2a plays a role in the development and maintenance of the noradrenergic cell type by regulating the transcription of genes involved in the biosynthesis and metabolism of noradrenaline.	Norepinephrine	203-216	paired like homeobox 2A	Homo sapiens	29-35
15936529-2	2005	Noradrenaline (NA) is catabolized by monoamine oxidase A (MAOA) and cathecol-O-methyl transferase (COMT).	Norepinephrine	0-13	catechol-O-methyltransferase	Homo sapiens	68-97
15936529-2	2005	Noradrenaline (NA) is catabolized by monoamine oxidase A (MAOA) and cathecol-O-methyl transferase (COMT).	Norepinephrine	0-13	catechol-O-methyltransferase	Homo sapiens	99-103
15956122-11	2005	The subjects carrying the beta2-polymorphisms linked to weight gain and BP elevation also have higher plasma norepinephrine levels that are present at entry before weight gain and BP elevation.	Norepinephrine	109-123	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	26-31
15924571-4	2005	Likewise, the increased levels of UCP3 and cAMP-dependent protein kinase in the brown adipose tissue of Ucp1-/- mice given the standard diet were decreased significantly in that of Ucp1-/- mice fed the HF diet, which animals showed impaired norepinephrine-induced lipolysis in their adipose tissues.	Norepinephrine	241-255	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	34-38
15924571-4	2005	Likewise, the increased levels of UCP3 and cAMP-dependent protein kinase in the brown adipose tissue of Ucp1-/- mice given the standard diet were decreased significantly in that of Ucp1-/- mice fed the HF diet, which animals showed impaired norepinephrine-induced lipolysis in their adipose tissues.	Norepinephrine	241-255	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	104-108
15924571-4	2005	Likewise, the increased levels of UCP3 and cAMP-dependent protein kinase in the brown adipose tissue of Ucp1-/- mice given the standard diet were decreased significantly in that of Ucp1-/- mice fed the HF diet, which animals showed impaired norepinephrine-induced lipolysis in their adipose tissues.	Norepinephrine	241-255	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	181-185
15941038-0	2005	Improved assay for catechol-O-methyltransferase activity utilizing norepinephrine as an enzymatic substrate and reversed-phase high-performance liquid chromatography with fluorescence detection.	Norepinephrine	67-81	catechol-O-methyltransferase	Homo sapiens	19-47
15941038-1	2005	We have previously established a rapid catechol-O-methyltransferase (COMT) assay using norepinephrine (NE) as a natural substrate and flow-injection analysis.	Norepinephrine	87-101	catechol-O-methyltransferase	Homo sapiens	39-67
15941038-1	2005	We have previously established a rapid catechol-O-methyltransferase (COMT) assay using norepinephrine (NE) as a natural substrate and flow-injection analysis.	Norepinephrine	87-101	catechol-O-methyltransferase	Homo sapiens	69-73
15831359-8	2005	RESULTS: In vessels from the low salt animals leptin caused a dose-dependent dilatation (maximum change 31.4% +/- 5.8% of the initial norepinephrine-induced constriction) but in the high salt animals the change was only 3.4% +/- 1.1%.	Norepinephrine	134-148	leptin	Rattus norvegicus	46-52
15526278-2	2005	We have examined this issue further, using cultured rat hepatocytes, and report here that various G protein-coupled receptor (GPCR) agonists, including vasopressin (VP), angiotensin II (Ang.II), prostaglandin F2alpha, and norepinephrine (NE), may give rise to a prolonged phosphoinositide hydrolysis.	Norepinephrine	222-236	G protein-coupled bile acid receptor 1	Rattus norvegicus	126-130
15652259-1	2005	Neuropeptide Y (NPY) is primarily synthesised and released by neurones, it is co-localised with noradrenaline and is involved in the regulation of cardiovascular function.	Norepinephrine	96-109	neuropeptide Y	Mus musculus	0-14
15652259-1	2005	Neuropeptide Y (NPY) is primarily synthesised and released by neurones, it is co-localised with noradrenaline and is involved in the regulation of cardiovascular function.	Norepinephrine	96-109	neuropeptide Y	Mus musculus	16-19
15652259-2	2005	In a mouse model lacking NPY Y1 receptor (KO), the ability of NPY to potentiate noradrenaline-induced vasoconstriction is abolished during stress but normal in baseline conditions, locomotor activity and metabolic rate are lowered, blood insulin levels and glucose storage activity are increased.	Norepinephrine	80-93	neuropeptide Y	Mus musculus	62-65
15673663-1	2005	Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine.	Norepinephrine	108-122	catechol-O-methyltransferase	Homo sapiens	0-28
15673663-1	2005	Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine.	Norepinephrine	108-122	catechol-O-methyltransferase	Homo sapiens	30-34
15518886-1	2004	Chromogranin A (CgA) is a member of a family of chromogranins, which are co-stored and co-released with adrenaline and noradrenalin (NAd) in the adrenal medulla in response to stimulation of the splanchnic nerve.	Norepinephrine	119-131	chromogranin A	Rattus norvegicus	0-14
15518886-1	2004	Chromogranin A (CgA) is a member of a family of chromogranins, which are co-stored and co-released with adrenaline and noradrenalin (NAd) in the adrenal medulla in response to stimulation of the splanchnic nerve.	Norepinephrine	119-131	chromogranin A	Rattus norvegicus	16-19
15518886-1	2004	Chromogranin A (CgA) is a member of a family of chromogranins, which are co-stored and co-released with adrenaline and noradrenalin (NAd) in the adrenal medulla in response to stimulation of the splanchnic nerve.	Norepinephrine	133-136	chromogranin A	Rattus norvegicus	0-14
15518886-1	2004	Chromogranin A (CgA) is a member of a family of chromogranins, which are co-stored and co-released with adrenaline and noradrenalin (NAd) in the adrenal medulla in response to stimulation of the splanchnic nerve.	Norepinephrine	133-136	chromogranin A	Rattus norvegicus	16-19
27997103-1	2017	Phenylethanolamine N-methyltransferase (PNMT) catalyzes the S-adenosyl-l-methionine (SAM)-dependent conversion of norepinephrine to epinephrine.	Norepinephrine	114-128	phenylethanolamine N-methyltransferase	Homo sapiens	40-44
15536455-3	2004	We studied the influence of this polymorphism on the responses to ETA antagonism in the presence of endothelin 1 (ET-1), norepinephrine (NA), and angiotensin II (ANGII).	Norepinephrine	121-135	endothelin receptor type A	Homo sapiens	66-69
28210225-11	2017	In 5/6Nx rats, ICV infusion of AT1R antagonist, Ras inhibitor, MEK inhibitor or caspase-3 inhibitor could lower systolic blood pressure (20.8-, 20.8-, 18.9-, 14.3%-fold) together with plasma norepinephrine (53.9-, 57.8-,63.3-, 52.3%-fold).	Norepinephrine	191-205	angiotensin II receptor, type 1a	Rattus norvegicus	31-35
14997275-2	2004	The effects of milnacipran, a selective inhibitor of the reuptake of serotonin and noradrenaline, on LGIC receptors have not yet been investigated on such ion-channel receptors.	Norepinephrine	83-96	glycine receptor alpha 3	Homo sapiens	101-105
28210225-11	2017	In 5/6Nx rats, ICV infusion of AT1R antagonist, Ras inhibitor, MEK inhibitor or caspase-3 inhibitor could lower systolic blood pressure (20.8-, 20.8-, 18.9-, 14.3%-fold) together with plasma norepinephrine (53.9-, 57.8-,63.3-, 52.3%-fold).	Norepinephrine	191-205	caspase 3	Rattus norvegicus	80-89
28652540-5	2017	Then, we showed that noradrenaline treatment stimulated ghrelin secretion via beta1-adrenergic receptor, and fasting-induced ghrelin elevation was completely inhibited by the beta1-adrenergic receptor antagonist in mice.	Norepinephrine	21-34	ghrelin	Mus musculus	56-63
15306127-0	2004	Effects of the selective norepinephrine uptake inhibitor nisoxetine on prodynorphin gene expression in rat CNS.	Norepinephrine	25-39	prodynorphin	Rattus norvegicus	71-83
15306127-4	2004	The effect of the selective norepinephrine uptake inhibitor nisoxetine was examined on PDYN gene expression.	Norepinephrine	28-42	prodynorphin	Rattus norvegicus	87-91
15276647-0	2004	Increased gut-derived norepinephrine release in sepsis: up-regulation of intestinal tyrosine hydroxylase.	Norepinephrine	22-36	tyrosine hydroxylase	Rattus norvegicus	84-104
15100092-7	2004	Addition of the sympathetic agonists norepinephrine, isoprenaline, or BRL-37344 (beta(3)-agonist) led to falls in NGF gene expression and secretion by 3T3-L1 adipocytes, as did IL-6 and the PPARgamma agonist rosiglitazone.	Norepinephrine	37-51	peroxisome proliferator activated receptor gamma	Mus musculus	190-199
14960487-6	2004	CGRP (10(-10) to 10(-7) M) produced a concentration-dependent relaxation of norepinephrine-induced contractions in Day 18 pregnant rat uterine arteries.	Norepinephrine	76-90	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
15607494-1	2004	Our main objective was to study the interaction of BKCa channel modulators with adrenergic agonists UK 14304 and noradrenaline (NA), acting on alpha1-adrenoceptors, in the rat aorta and how this is affected by receptor reserve.	Norepinephrine	113-126	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	51-55
15094078-7	2004	In late-onset sporadic Alzheimer disease, the neuronal insulin receptor may be desensitized by inhibition of receptor function at different sites by noradrenaline and/or cortisol, the levels of which both increase with increasing age.	Norepinephrine	149-162	insulin receptor	Homo sapiens	55-71
27287619-6	2016	Spleen contraction in response to exogenous norepinephrine (NE) was found to be significantly lower in Cnr1 -/- /Cnr2 -/- mouse spleens, likely due to decreased expression of capsular alpha1AR.	Norepinephrine	44-58	cannabinoid receptor 1 (brain)	Mus musculus	103-107
28032000-3	2016	The enzyme catechol O-methyltransferase (COMT) catabolizes dopamine and norepinephrine in the prefrontal cortex and striatum, brain regions involved in behavioral control.	Norepinephrine	72-86	catechol-O-methyltransferase	Homo sapiens	11-39
28032000-3	2016	The enzyme catechol O-methyltransferase (COMT) catabolizes dopamine and norepinephrine in the prefrontal cortex and striatum, brain regions involved in behavioral control.	Norepinephrine	72-86	catechol-O-methyltransferase	Homo sapiens	41-45
27821918-4	2016	[Results] Significant differences in norepinephrine, cortisol and blood pressure (SBP &amp; DBP) were found in terms of interaction by time interval and between groups.	Norepinephrine	37-51	selenium binding protein 1	Homo sapiens	82-85
27029212-10	2016	Signaling from the 5-HT1A receptors and alpha2-adrenoceptors was not involved in the decrease in the basal noradrenaline levels but partially affected the noradrenaline response.	Norepinephrine	155-168	5-hydroxytryptamine receptor 1A	Rattus norvegicus	19-25
27452863-7	2016	Norepinephrine depresses aggrecans expression but stimulates MMP-3, MMP-13 and RANKL production by chondrocytes through ERK1/2 and PKA pathway; these effects were abolished by an alpha2A-adrenoreceptor antagonist.	Norepinephrine	0-14	TNF superfamily member 11	Rattus norvegicus	79-84
27452863-7	2016	Norepinephrine depresses aggrecans expression but stimulates MMP-3, MMP-13 and RANKL production by chondrocytes through ERK1/2 and PKA pathway; these effects were abolished by an alpha2A-adrenoreceptor antagonist.	Norepinephrine	0-14	mitogen activated protein kinase 3	Rattus norvegicus	120-126
27452863-7	2016	Norepinephrine depresses aggrecans expression but stimulates MMP-3, MMP-13 and RANKL production by chondrocytes through ERK1/2 and PKA pathway; these effects were abolished by an alpha2A-adrenoreceptor antagonist.	Norepinephrine	0-14	adrenoceptor alpha 2A	Rattus norvegicus	179-201
27151940-2	2016	Recently, we demonstrated in a preclinical model that rats subjected to neonatal colon inflammation show increased basal plasma norepinephrine (NE), which contributes to GHS through the upregulation of nerve growth factor (NGF) expression in the gastric fundus.	Norepinephrine	128-142	nerve growth factor	Rattus norvegicus	202-221
27151940-2	2016	Recently, we demonstrated in a preclinical model that rats subjected to neonatal colon inflammation show increased basal plasma norepinephrine (NE), which contributes to GHS through the upregulation of nerve growth factor (NGF) expression in the gastric fundus.	Norepinephrine	128-142	nerve growth factor	Rattus norvegicus	223-226
27312548-10	2016	In a conclusion, there is a relationship between the elevated expression of P2X3 receptor and P2X7 receptor in peripheral blood leukocytes and high serum epinephrine and norepinephrine levels in hyperthyroidism patients.	Norepinephrine	170-184	purinergic receptor P2X 3	Homo sapiens	76-80
27305421-10	2016	In the probabilistic sensitivity analysis, it was verified that the cost of the treatment with noradrenaline could vary between Int$2,326.53 and Int$3,644.16, while costs related to the treatment using terlipressin are not variable.	Norepinephrine	95-108	fibroblast growth factor 3	Homo sapiens	128-133
26843180-4	2016	To our knowledge, significant interactions between norepinephrine and D2R or D3R receptors have not been demonstrated.	Norepinephrine	51-65	dopamine receptor D2	Homo sapiens	70-73
26023064-2	2016	Neurons expressing the neuropeptide, relaxin-3 (RLN3), and its cognate receptor, RXFP3, constitute a putative "ascending arousal system", which shares neuroanatomical and functional similarities with serotonin (5-HT)/dorsal raphe and noradrenaline (NA)/locus coeruleus monoamine systems.	Norepinephrine	234-247	relaxin family peptide receptor 3	Mus musculus	81-86
26724392-8	2016	Treatment of the cells with noradrenaline (10muM) for 24h increased the protein level of the catalytic subunit of glutamate-cysteine ligase (GCLc), the rate-limiting enzyme of GSH synthesis; and this increase was inhibited by SR59230A.	Norepinephrine	28-41	glutamate-cysteine ligase catalytic subunit	Homo sapiens	141-145
26724392-9	2016	These results thus suggest that noradrenaline increased the GSH concentration in astrocytes by inducing GCLc protein in them via beta3-adrenoceptor stimulation.	Norepinephrine	32-45	glutamate-cysteine ligase catalytic subunit	Homo sapiens	104-108
26608656-3	2016	Preclinical studies found that neonatal colon inflammation elevates plasma norepinephrine (NE), which upregulates expression of nerve growth factor (NGF) in the muscularis externa of the gastric fundus.	Norepinephrine	75-89	nerve growth factor	Rattus norvegicus	128-147
26608656-3	2016	Preclinical studies found that neonatal colon inflammation elevates plasma norepinephrine (NE), which upregulates expression of nerve growth factor (NGF) in the muscularis externa of the gastric fundus.	Norepinephrine	75-89	nerve growth factor	Rattus norvegicus	149-152
26450431-4	2015	RESULTS: RDX decreased plasma and renal tissue noradrenaline (norepinephrine) levels and BP.	Norepinephrine	47-60	radixin	Rattus norvegicus	9-12
26450431-4	2015	RESULTS: RDX decreased plasma and renal tissue noradrenaline (norepinephrine) levels and BP.	Norepinephrine	62-76	radixin	Rattus norvegicus	9-12
26254103-4	2015	Aortas from wild-type (Lcat(wt)) and LCAT knockout (Lcat(KO)) mice exposed to noradrenaline showed reduced contractility in Lcat(KO) mice (P&lt;0.005), whereas acetylcholine exposure showed a lower NO-dependent relaxation in Lcat(KO) mice (P&lt;0.05).	Norepinephrine	78-91	lecithin cholesterol acyltransferase	Mus musculus	23-27
26254103-4	2015	Aortas from wild-type (Lcat(wt)) and LCAT knockout (Lcat(KO)) mice exposed to noradrenaline showed reduced contractility in Lcat(KO) mice (P&lt;0.005), whereas acetylcholine exposure showed a lower NO-dependent relaxation in Lcat(KO) mice (P&lt;0.05).	Norepinephrine	78-91	lecithin cholesterol acyltransferase	Mus musculus	37-41
26254103-4	2015	Aortas from wild-type (Lcat(wt)) and LCAT knockout (Lcat(KO)) mice exposed to noradrenaline showed reduced contractility in Lcat(KO) mice (P&lt;0.005), whereas acetylcholine exposure showed a lower NO-dependent relaxation in Lcat(KO) mice (P&lt;0.05).	Norepinephrine	78-91	lecithin cholesterol acyltransferase	Mus musculus	52-56
26254103-4	2015	Aortas from wild-type (Lcat(wt)) and LCAT knockout (Lcat(KO)) mice exposed to noradrenaline showed reduced contractility in Lcat(KO) mice (P&lt;0.005), whereas acetylcholine exposure showed a lower NO-dependent relaxation in Lcat(KO) mice (P&lt;0.05).	Norepinephrine	78-91	lecithin cholesterol acyltransferase	Mus musculus	52-56
26254103-4	2015	Aortas from wild-type (Lcat(wt)) and LCAT knockout (Lcat(KO)) mice exposed to noradrenaline showed reduced contractility in Lcat(KO) mice (P&lt;0.005), whereas acetylcholine exposure showed a lower NO-dependent relaxation in Lcat(KO) mice (P&lt;0.05).	Norepinephrine	78-91	lecithin cholesterol acyltransferase	Mus musculus	52-56
25724763-3	2015	This review summarizes the body of research focused on N/OFQ and its specific receptor, the nociceptin receptor (NOP receptor), in learning and memory, and its potential mechanisms of action, in which acetylcholine, NMDA receptor, and noradrenaline may be critical.	Norepinephrine	235-248	opioid related nociceptin receptor 1	Homo sapiens	92-111
26253436-1	2015	Catechol-O-methyltransferase (COMT) is a methylation enzyme engaged in the degradation of dopamine and noradrenaline by catalyzing the transfer of a methyl group from S-adenosylmethionine.	Norepinephrine	103-116	catechol-O-methyltransferase	Homo sapiens	0-28
26253436-1	2015	Catechol-O-methyltransferase (COMT) is a methylation enzyme engaged in the degradation of dopamine and noradrenaline by catalyzing the transfer of a methyl group from S-adenosylmethionine.	Norepinephrine	103-116	catechol-O-methyltransferase	Homo sapiens	30-34
26121187-2	2015	Norepinephrine is highly involved in the stress response and the alpha2A-adrenoceptor, which is an important regulator of norepinephrine signalling, is a putative target in pharmacotherapy of AUD.	Norepinephrine	122-136	adrenoceptor alpha 2A	Rattus norvegicus	65-85
25482272-1	2015	AIM: Neuropeptide Y (NPY) co-localized with noradrenaline in central and sympathetic nervous systems seems to play a role in the control of energy metabolism.	Norepinephrine	44-57	neuropeptide Y	Mus musculus	5-19
25482272-1	2015	AIM: Neuropeptide Y (NPY) co-localized with noradrenaline in central and sympathetic nervous systems seems to play a role in the control of energy metabolism.	Norepinephrine	44-57	neuropeptide Y	Mus musculus	21-24
25912576-0	2015	Norepinephrine attenuates CXCR4 expression and the corresponding invasion of MDA-MB-231 breast cancer cells via beta2-adrenergic receptors.	Norepinephrine	0-14	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	112-117
25912576-11	2015	Finally, we found the specific beta2-adrenergic antagonist, ICI 118,551, eliminated the impact of norepinephrine on CXCR4 expression.	Norepinephrine	98-112	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	31-36
25691620-7	2015	Furthermore, norepinephrine caused an increase in G1 arrest in norepinephrine-treated T-lymphocytes, and this was accompanied by a decrease in pro-growth cyclin D3, E1, and E2 mRNA expression.	Norepinephrine	13-27	cyclin D3	Mus musculus	154-163
25691620-7	2015	Furthermore, norepinephrine caused an increase in G1 arrest in norepinephrine-treated T-lymphocytes, and this was accompanied by a decrease in pro-growth cyclin D3, E1, and E2 mRNA expression.	Norepinephrine	13-27	skull morphology 2	Mus musculus	165-175
25176177-7	2015	Loss of SLC10A4 in mice resulted in reduced striatal serotonin, noradrenaline, and dopamine concentrations and a significantly higher dopamine turnover ratio.	Norepinephrine	64-77	solute carrier family 10 (sodium/bile acid cotransporter family), member 4	Mus musculus	8-15
25304347-4	2015	To activate nuclear adrenergic receptors in adult cardiac myocytes, uptake of endogenous catecholamines epinephrine and norepinephrine occurs via organic cation transporter 3 (OCT3), a member of the slc22a family of genes.	Norepinephrine	120-134	C-C motif chemokine ligand 21	Homo sapiens	199-202
25359531-3	2015	Here, we verified the hypothesis that CRH in the CeA sensitizes visceral nociception via CRH-R1 with release of noradrenaline, dopamine, and serotonin (5-HT) in the CeA.	Norepinephrine	112-125	carcinoembryonic antigen gene family 4	Rattus norvegicus	49-52
25359531-3	2015	Here, we verified the hypothesis that CRH in the CeA sensitizes visceral nociception via CRH-R1 with release of noradrenaline, dopamine, and serotonin (5-HT) in the CeA.	Norepinephrine	112-125	carcinoembryonic antigen gene family 4	Rattus norvegicus	165-168
25359531-9	2015	Noradrenaline in the CeA was increased by CRD, further increased by CRH, and inhibited by CRH-R1 antagonist.	Norepinephrine	0-13	carcinoembryonic antigen gene family 4	Rattus norvegicus	21-24
25359531-12	2015	CONCLUSIONS &amp; INFERENCES: These results suggest that CRH in the CeA sensitizes visceral nociception via CRH-R1 with release of noradrenaline.	Norepinephrine	131-144	carcinoembryonic antigen gene family 4	Rattus norvegicus	68-71
24803315-0	2014	The stress-related hormone norepinephrine induced upregulation of Nix, contributing to ECM protein expression.	Norepinephrine	27-41	BCL2 interacting protein 3 like	Homo sapiens	66-69
24535841-9	2014	Importantly, specific reintroduction of NPY solely in noradrenergic neurons of otherwise Npy-null mice blocks the increase in circulating noradrenaline and the stress-induced bone loss.	Norepinephrine	138-151	neuropeptide Y	Mus musculus	89-92
24912137-8	2014	Results show that the adenosine A2a receptor agonist, CGS 21680, increases neurotransmitter release, in particular, glutamate and noradrenaline and such response is mediated by protein kinase A activation, which in turn increased synapsin I phosphorylation.	Norepinephrine	130-143	adenosine A2a receptor	Rattus norvegicus	22-44
25024212-8	2014	Norepinephrine-evoked ICa,L responses were decreased by inhibition of Ca(2+)/calmodulin-dependent kinase II (CaMKII) in myocytes from patients with SR, but not in those from patients with AF.	Norepinephrine	0-14	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	70-107
25024212-8	2014	Norepinephrine-evoked ICa,L responses were decreased by inhibition of Ca(2+)/calmodulin-dependent kinase II (CaMKII) in myocytes from patients with SR, but not in those from patients with AF.	Norepinephrine	0-14	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	109-115
24829502-7	2014	Cort also increased baseline blood pressure by day 15 (99 +- 2 vs. 108 +- 3 mmHg for Sham- vs. Cort-treated rats, P &lt; 0.05) and elevated baseline plasma norepinephrine and neuropeptide Y concentrations.	Norepinephrine	156-170	cortistatin	Rattus norvegicus	0-4
24617839-11	2014	Norepinephrine axon density (marked with dopamine beta-hydroxylase) increased with stress in both HSR and SS groups (P &lt;= 0.002), whereas serotonin axon density was higher in HSR compared to SS animals and there was no effect of stress (P = 0.03).	Norepinephrine	0-14	dopamine beta-hydroxylase	Macaca fascicularis	41-66
24599448-6	2014	In the present study, these two behavioral assays were used to examine the role of norepinephrine (NE) transmission within the central nucleus of the amygdala (CeA) and the bed nucleus of the stria terminalis (BNST), each of which has been implicated in drug-withdrawal-induced anxiety and stress-induced response reinstatement.	Norepinephrine	83-97	carcinoembryonic antigen gene family 4	Rattus norvegicus	160-163
23963743-6	2014	Norepinephrine and CL 316,243-mediated induction of PGC-1alpha were decreased in cultured epididymal adipose tissue from AMPK beta1(-/-) relative to WT mice.	Norepinephrine	0-14	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	52-62
23963743-8	2014	CONCLUSIONS: Norepinephrine- and CL 316,243-mediated induction of PGC-1alpha and mitochondrial protein expression is regulated by AMPK in epididymal, but not inguinal adipose tissue.	Norepinephrine	13-27	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	66-76
24982877-1	2014	Human cardiac beta 1-AR perform a crucial role in mediating the cardiostimulating effects of norepinephrine.	Norepinephrine	93-107	adrenoceptor beta 1	Homo sapiens	14-23
24386355-6	2013	These brown adipocytes contained large amounts of UCP1 and increased their oxygen consumption when stimulated with norepinephirine.	Norepinephrine	115-130	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	50-54
23774690-1	2013	Catechol-O-methyltransferase (COMT) inactivates the catecholamines adrenaline, noradrenaline and dopamine.	Norepinephrine	79-92	catechol-O-methyltransferase	Homo sapiens	0-28
23774690-1	2013	Catechol-O-methyltransferase (COMT) inactivates the catecholamines adrenaline, noradrenaline and dopamine.	Norepinephrine	79-92	catechol-O-methyltransferase	Homo sapiens	30-34
23772221-14	2013	In conclusion, peripheral alpha2CAR-stimulation or AT1R-inhibition restored failing alpha2AAR-mediated auto-inhibition of norepinephrine and epinephrine release and control of TPR in SHR.	Norepinephrine	122-136	adrenoceptor alpha 2C	Rattus norvegicus	26-35
23772221-14	2013	In conclusion, peripheral alpha2CAR-stimulation or AT1R-inhibition restored failing alpha2AAR-mediated auto-inhibition of norepinephrine and epinephrine release and control of TPR in SHR.	Norepinephrine	122-136	angiotensin II receptor, type 1a	Rattus norvegicus	51-55
23772221-14	2013	In conclusion, peripheral alpha2CAR-stimulation or AT1R-inhibition restored failing alpha2AAR-mediated auto-inhibition of norepinephrine and epinephrine release and control of TPR in SHR.	Norepinephrine	122-136	adrenoceptor alpha 2A	Rattus norvegicus	84-93
23341457-8	2013	It was also shown that the C2 domain was required for PRIP to suppress SDS-resistant ternary SNARE complex formation and inhibit high K(+)-induced noradrenalin release from PC12 cells.	Norepinephrine	147-159	nuclear receptor coactivator 6	Rattus norvegicus	54-58
23433357-9	2013	RESULTS: Circulating noradrenaline and adrenaline correlated weakly but independently with syndecan-1 (rho = 0.15 and rho = 0.13, both P &lt;0.01) and thrombomodulin (rho = 0.11 and rho = 0.17, both P &lt;0.01), biomarkers of glycocalyx and endothelial cell damage, respectively.	Norepinephrine	21-34	syndecan 1	Homo sapiens	91-101
22738191-7	2013	As expected, Tg mice showed a significant decrease in the cardiac amounts of the MAO-A substrates serotonin and norepinephrine.	Norepinephrine	112-126	monoamine oxidase A	Mus musculus	81-86
23936817-0	2013	Leptin modulates norepinephrine-mediated melatonin synthesis in cultured rat pineal gland.	Norepinephrine	17-31	leptin	Rattus norvegicus	0-6
23936817-2	2013	Because melatonin appears to alter leptin synthesis, in this work we aimed to investigate whether leptin would have a role on norepinephrine- (NE-)mediated melatonin synthesis in cultured rat pineal glands.	Norepinephrine	126-140	leptin	Rattus norvegicus	98-104
23162530-15	2012	CONCLUSIONS: alpha(2A)AR inhibition increased norepinephrine overflow only when re-uptake was blocked, and then with particular efficacy in SHR, possibly due to their high sympathetic tone.	Norepinephrine	46-60	adrenoceptor alpha 2A	Rattus norvegicus	13-24
22685264-0	2012	Different signaling mechanisms are involved in the norepinephrine-stimulated TORC1 and TORC2 nuclear translocation in rat pinealocytes.	Norepinephrine	51-65	CREB regulated transcription coactivator 1	Rattus norvegicus	77-82
22685264-4	2012	Stimulation of pinealocytes with norepinephrine (NE), although having no effect on Torc1 transcription, caused rapid dephosphorylation of TORC1.	Norepinephrine	33-47	CREB regulated transcription coactivator 1	Rattus norvegicus	138-143
22723698-1	2012	Converging evidence shows that monoamine oxidase A (MAO A), the key enzyme catalyzing serotonin (5-hydroxytryptamine; 5-HT) and norepinephrine (NE) degradation, is a primary factor in the pathophysiology of antisocial and aggressive behavior.	Norepinephrine	128-142	monoamine oxidase A	Mus musculus	31-50
22723698-1	2012	Converging evidence shows that monoamine oxidase A (MAO A), the key enzyme catalyzing serotonin (5-hydroxytryptamine; 5-HT) and norepinephrine (NE) degradation, is a primary factor in the pathophysiology of antisocial and aggressive behavior.	Norepinephrine	128-142	monoamine oxidase A	Mus musculus	52-57
21392097-2	2012	In the present study, we investigated whether calcitonin ameliorates diminished blood flow and enhanced arterial contraction in response to noradrenaline in chronic constriction injury (CCI) of the sciatic nerve in rats.	Norepinephrine	140-153	calcitonin-related polypeptide alpha	Rattus norvegicus	46-56
22579288-3	2012	BMP8B is induced by nutritional and thermogenic factors in mature BAT, increasing the response to noradrenaline through enhanced p38MAPK/CREB signaling and increased lipase activity.	Norepinephrine	98-111	mitogen-activated protein kinase 14	Mus musculus	129-136
22483297-1	2012	The enzyme catechol-O-methyltransferase (COMT) has been shown to play a critical role in pain perception by regulating levels of epinephrine (Epi) and norepinephrine (NE).	Norepinephrine	151-165	catechol-O-methyltransferase	Homo sapiens	11-39
22483297-1	2012	The enzyme catechol-O-methyltransferase (COMT) has been shown to play a critical role in pain perception by regulating levels of epinephrine (Epi) and norepinephrine (NE).	Norepinephrine	151-165	catechol-O-methyltransferase	Homo sapiens	41-45
22493069-7	2012	A 4-hour ICV infusion of SDF-1 increased plasma levels of arginine vasopressin, adrenocorticotropic hormone, and norepinephrine in normal rats, responses that were prevented by pretreatment with ICV SDF-1 short-hairpin RNA (shRNA).	Norepinephrine	113-127	C-X-C motif chemokine ligand 12	Rattus norvegicus	25-30
22493069-8	2012	ICV administration of SDF-1 shRNA also reduced plasma arginine vasopressin, adrenocorticotropic hormone, and norepinephrine levels in HF rats.	Norepinephrine	109-123	C-X-C motif chemokine ligand 12	Rattus norvegicus	22-27
22422821-2	2012	We have found previously that G-CSF-enforced mobilization is controlled by peripheral sympathetic nerves via norepinephrine (NE) signaling.	Norepinephrine	109-123	peripheral blood stem cell response to granulocyte colony stimulating factor 1	Mus musculus	30-35
22420844-1	2012	A family of different 3,5-disubstituted indole derivatives having 6-membered rings were designed, synthesized, and demonstrated inhibition of human nitric oxide synthase (NOS) with norepinephrine reuptake inhibitory activity (NERI).	Norepinephrine	181-195	nitric oxide synthase 1	Homo sapiens	148-169
22226998-8	2012	KCNMA1 gene silencing increased SM sensitivity to norepinephrine while Ach-induced relaxation had decreased.	Norepinephrine	50-64	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	0-6
20547474-9	2011	The association of the two cell types may be particularly important in the amphibians and birds because like in mammals, the enzyme catalysing the methylation of noradrenaline to adrenaline, PNMT, is under the control of the steroid cortisol.	Norepinephrine	162-175	phenylethanolamine N-methyltransferase	Homo sapiens	191-195
21784134-0	2011	Nerve growth factor augments neuronal responsiveness to noradrenaline in cultured dorsal root ganglion neurons of rats.	Norepinephrine	56-69	nerve growth factor	Rattus norvegicus	0-19
21784134-3	2011	The present study tested the hypothesis that NGF could affect neuronal responsiveness to noradrenaline (NA) on the nociceptive DRG neurons, thus enhancing the nociceptive signals.	Norepinephrine	89-102	nerve growth factor	Rattus norvegicus	45-48
21846718-1	2011	Catechol-O-methyltransferase (COMT) is a key enzyme for inactivation and metabolism of catechols, including dopamine, norepinephrine, caffeine, and estrogens.	Norepinephrine	118-132	catechol-O-methyltransferase	Homo sapiens	0-28
21846718-1	2011	Catechol-O-methyltransferase (COMT) is a key enzyme for inactivation and metabolism of catechols, including dopamine, norepinephrine, caffeine, and estrogens.	Norepinephrine	118-132	catechol-O-methyltransferase	Homo sapiens	30-34
21434894-2	2011	The attenuation in noradrenaline-mediated vasoconstriction is because of enhanced beta(2)-adrenergic stimulation in women.	Norepinephrine	19-32	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	82-88
21442465-7	2011	The administration of desipramine, a specific inhibitor of noradrenaline reuptake, prevented the increase in Nur77-like immunoreactivity and mRNA induced by stress in rats subjected to repeated exposure to immobilization stress.	Norepinephrine	59-72	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	109-114
21795689-8	2011	In functional secretion assays, nicotine-evoked [(3)H]norepinephrine release from cells overexpressing Plg-R(KT) was markedly decreased (by 51 +- 2%, p &lt; 0.001) when compared with control transfected cells, and antibody blockade increased [(3)H]norepinephrine release from non-transfected PC12 cells.	Norepinephrine	53-68	plasminogen receptor with a C-terminal lysine	Rattus norvegicus	103-112
21795689-8	2011	In functional secretion assays, nicotine-evoked [(3)H]norepinephrine release from cells overexpressing Plg-R(KT) was markedly decreased (by 51 +- 2%, p &lt; 0.001) when compared with control transfected cells, and antibody blockade increased [(3)H]norepinephrine release from non-transfected PC12 cells.	Norepinephrine	54-68	plasminogen receptor with a C-terminal lysine	Rattus norvegicus	103-112
21494253-7	2011	Norepinephrine treatment, mimicking acute stress, rapidly increased SDF-1 release and progenitor cell mobilization, whereas beta2-adrenergic antagonist inhibited both steady state and AMD3100-induced SDF-1 release and progenitor cell mobilization in mice.	Norepinephrine	0-14	chemokine (C-X-C motif) ligand 12	Mus musculus	68-73
21695287-1	2011	Catechol-O-methyltransferase (COMT) metabolizes catechol neurotransmitters dopamine, noradrenaline and adrenaline that are involved in various physiological functions including mood, cognition and stress response.	Norepinephrine	85-98	catechol-O-methyltransferase	Homo sapiens	0-28
21695287-1	2011	Catechol-O-methyltransferase (COMT) metabolizes catechol neurotransmitters dopamine, noradrenaline and adrenaline that are involved in various physiological functions including mood, cognition and stress response.	Norepinephrine	85-98	catechol-O-methyltransferase	Homo sapiens	30-34
21317437-5	2011	Norepinephrine, acting via beta-adrenergic, cAMP-mediated, mechanisms and subsequent activation of protein kinase A and p38 MAPK, induces FGF21 gene transcription and also FGF21 release in brown adipocytes.	Norepinephrine	0-14	fibroblast growth factor 21	Rattus norvegicus	172-177
21262224-8	2011	Preincubation with either the COX-1/2 or COX-2 inhibitor (indomethacin and NS-398, respectively) decreased the noradrenaline contraction in aldosterone-treated animals, while this response was not modified by COX-1 inhibitor SC-560.	Norepinephrine	111-124	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	41-46
21456501-8	2011	Norepinephrine levels in both experimental groups were significantly elevated compared to controls, too (p &lt; 0.001 LDC vs C; p &lt; 0.01 HDC vs C).	Norepinephrine	0-14	histidine decarboxylase	Rattus norvegicus	140-143
21456501-10	2011	We speculate that lesser negative effect of HDC compared to LDC on the preimplantation embryo development could be the consequence of the lesser norepinephrine levels and/or elevated serotonin levels (Tab.	Norepinephrine	145-159	histidine decarboxylase	Rattus norvegicus	44-47
21865666-5	2011	Basal production of cyclic adenosine monophosphate (cAMP) was not affected, but responses to GTPgammaS, isoprenaline, noradrenaline, SKF 38393 and forskolin were depressed in the Ts65Dn hippocampus.	Norepinephrine	118-131	reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65	Mus musculus	179-185
21273786-9	2011	Moreover, inhibition of COX-2 or incubation with superoxide dismutase restores noradrenaline-induced contraction in the 20-week ouabain group to control levels.	Norepinephrine	79-92	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	24-29
20637710-10	2010	We also found that ephA4 increased basal release of norepinephrine from nerve terminals of isolated tail arteries.	Norepinephrine	52-66	Eph receptor A4	Rattus norvegicus	19-24
20139013-3	2010	Here, we examined the impact of the catechol-O-methyltransferase (COMT) Val(108/158)Met polymorphism, involved in dopamine and norepinephrine catabolism, on both emotional brain function and self-reported negativity bias.	Norepinephrine	127-141	catechol-O-methyltransferase	Homo sapiens	36-64
20139013-3	2010	Here, we examined the impact of the catechol-O-methyltransferase (COMT) Val(108/158)Met polymorphism, involved in dopamine and norepinephrine catabolism, on both emotional brain function and self-reported negativity bias.	Norepinephrine	127-141	catechol-O-methyltransferase	Homo sapiens	66-70
20642456-2	2010	PNMT (phenylethanolamine N-methyltransferase) catalyses the final step in the biosynthesis of adrenaline, the conversion of noradrenaline (norepinephrine) to adrenaline by methylation.	Norepinephrine	124-137	phenylethanolamine N-methyltransferase	Homo sapiens	0-4
20642456-2	2010	PNMT (phenylethanolamine N-methyltransferase) catalyses the final step in the biosynthesis of adrenaline, the conversion of noradrenaline (norepinephrine) to adrenaline by methylation.	Norepinephrine	124-137	phenylethanolamine N-methyltransferase	Homo sapiens	6-44
20642456-2	2010	PNMT (phenylethanolamine N-methyltransferase) catalyses the final step in the biosynthesis of adrenaline, the conversion of noradrenaline (norepinephrine) to adrenaline by methylation.	Norepinephrine	139-153	phenylethanolamine N-methyltransferase	Homo sapiens	0-4
20642456-2	2010	PNMT (phenylethanolamine N-methyltransferase) catalyses the final step in the biosynthesis of adrenaline, the conversion of noradrenaline (norepinephrine) to adrenaline by methylation.	Norepinephrine	139-153	phenylethanolamine N-methyltransferase	Homo sapiens	6-44
20642456-10	2010	We synthesized five elaborated benzimidazole compounds and characterized their binding to PNMT, showing for the first time how this class of inhibitors interact with the noradrenaline-binding site.	Norepinephrine	170-183	phenylethanolamine N-methyltransferase	Homo sapiens	90-94
20587130-4	2010	The injection of POMC siRNA oligonucleotides suppressed the anorexic effects of sibutramine, a serotonin and noradrenaline re-uptake inhibitor.	Norepinephrine	109-122	pro-opiomelanocortin-alpha	Mus musculus	17-21
19725917-6	2010	Pre-incubation of mesenteric arterioles with anti-TRPC1 and anti-TRPC3 antibodies significantly reduced norepinephrine-induced vasomotion and calcium influx.	Norepinephrine	104-118	transient receptor potential cation channel, subfamily C, member 3	Rattus norvegicus	65-70
20713709-5	2010	Addition of norepinephrine or epinephrine to the culture medium stimulated ghrelin secretion, and this effect was blocked by atenolol, a selective beta(1)-adrenergic antagonist.	Norepinephrine	12-26	ghrelin	Mus musculus	75-82
20511116-7	2010	The proportion of alpha(1A)-adrenoceptor increased after treatment with noradrenaline, suggesting differences in agonist-mediated trafficking.	Norepinephrine	72-85	adrenoceptor alpha 1A	Rattus norvegicus	18-40
20403087-11	2010	High-dose corticosterone administration together with norepinephrine caused release of plasma oxytocin and hippocampal oxytocin receptor.	Norepinephrine	54-68	oxytocin receptor	Rattus norvegicus	119-136
19894083-1	2010	One of the limitations of non-selective monoamine oxidase (MAO) inhibitors as anti-depressant or anti-Parkinson drugs is their ability to potentiate the cardiovascular effect of oral tyramine, resulting from inhibition of systemic MAO-A and release of noradrenaline.	Norepinephrine	252-265	monoamine oxidase A	Rattus norvegicus	40-57
19894083-1	2010	One of the limitations of non-selective monoamine oxidase (MAO) inhibitors as anti-depressant or anti-Parkinson drugs is their ability to potentiate the cardiovascular effect of oral tyramine, resulting from inhibition of systemic MAO-A and release of noradrenaline.	Norepinephrine	252-265	monoamine oxidase A	Rattus norvegicus	59-62
20519641-9	2010	Norepinephrine, angiotensin II, and transforming growth factor-beta increased CgB gene expression in cardiomyocytes.	Norepinephrine	0-14	chromogranin B	Homo sapiens	78-81
19941049-2	2010	COMT and MAOA each contribute to the enzymatic degradation of dopamine and noradrenaline.	Norepinephrine	75-88	catechol-O-methyltransferase	Homo sapiens	0-4
20389021-3	2010	In an orthotopic mouse model of human ovarian cancer, restraint stress and the associated increases in norepinephrine and epinephrine protected the tumor cells from anoikis and promoted their growth by activating focal adhesion kinase (FAK).	Norepinephrine	103-117	protein tyrosine kinase 2	Homo sapiens	213-234
20389021-3	2010	In an orthotopic mouse model of human ovarian cancer, restraint stress and the associated increases in norepinephrine and epinephrine protected the tumor cells from anoikis and promoted their growth by activating focal adhesion kinase (FAK).	Norepinephrine	103-117	protein tyrosine kinase 2	Homo sapiens	236-239
20389021-6	2010	These data suggest that FAK modulation by stress hormones, especially norepinephrine and epinephrine, can contribute to tumor progression in patients with ovarian cancer and may point to potential new therapeutic targets for cancer management.	Norepinephrine	70-84	protein tyrosine kinase 2	Homo sapiens	24-27
20136691-13	2010	The data show that while pCREB and Sp1 bind to CRE-2, or GR to cGRE of the TRH promoter, the mutual antagonism between cAMP and glucocorticoid signalling, which prevent their binding to TRH promoter, could serve as a mechanism by which glucocorticoids rapidly suppress cAMP and noradrenaline-stimulated TRH transcription.	Norepinephrine	278-291	thyrotropin releasing hormone	Rattus norvegicus	75-78
20136691-13	2010	The data show that while pCREB and Sp1 bind to CRE-2, or GR to cGRE of the TRH promoter, the mutual antagonism between cAMP and glucocorticoid signalling, which prevent their binding to TRH promoter, could serve as a mechanism by which glucocorticoids rapidly suppress cAMP and noradrenaline-stimulated TRH transcription.	Norepinephrine	278-291	thyrotropin releasing hormone	Rattus norvegicus	186-189
20136691-13	2010	The data show that while pCREB and Sp1 bind to CRE-2, or GR to cGRE of the TRH promoter, the mutual antagonism between cAMP and glucocorticoid signalling, which prevent their binding to TRH promoter, could serve as a mechanism by which glucocorticoids rapidly suppress cAMP and noradrenaline-stimulated TRH transcription.	Norepinephrine	278-291	thyrotropin releasing hormone	Rattus norvegicus	186-189
20061033-0	2010	Noradrenaline reuptake inhibitors inhibit expression of chemokines IP-10 and RANTES and cell adhesion molecules VCAM-1 and ICAM-1 in the CNS following a systemic inflammatory challenge.	Norepinephrine	0-13	C-X-C motif chemokine ligand 10	Rattus norvegicus	67-72
20061033-0	2010	Noradrenaline reuptake inhibitors inhibit expression of chemokines IP-10 and RANTES and cell adhesion molecules VCAM-1 and ICAM-1 in the CNS following a systemic inflammatory challenge.	Norepinephrine	0-13	vascular cell adhesion molecule 1	Rattus norvegicus	112-118
19894027-2	2010	Our previous studies have indicated that the release of the sympathetic neurotransmitter, norepinephrine (NE), from the gut is increased in sepsis, and that NE potentiates endotoxin-induced tumor necrosis factor (TNF)-alpha upregulation via the A subtype of alpha(2)-adrenoceptors (i.e., alpha(2A)-AR) expressed on the surface of Kupffer cells.	Norepinephrine	90-104	adrenoceptor alpha 2A	Rattus norvegicus	258-280
19520435-1	2010	Catechol-O-methyltransferase (COMT) inactivates norepinephrine and dopamine via methyl conjugation, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity.	Norepinephrine	48-62	catechol-O-methyltransferase	Homo sapiens	0-28
19520435-1	2010	Catechol-O-methyltransferase (COMT) inactivates norepinephrine and dopamine via methyl conjugation, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity.	Norepinephrine	48-62	catechol-O-methyltransferase	Homo sapiens	30-34
19520435-1	2010	Catechol-O-methyltransferase (COMT) inactivates norepinephrine and dopamine via methyl conjugation, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity.	Norepinephrine	48-62	catechol-O-methyltransferase	Homo sapiens	128-132
20595783-0	2010	Noradrenaline induces clock gene Per1 mRNA expression in C6 glioma cells through beta(2)-adrenergic receptor coupled with protein kinase A - cAMP response element binding protein (PKA-CREB) and Src-tyrosine kinase - glycogen synthase kinase-3beta (Src-GSK-3beta).	Norepinephrine	0-13	clock circadian regulator	Homo sapiens	22-27
20595783-0	2010	Noradrenaline induces clock gene Per1 mRNA expression in C6 glioma cells through beta(2)-adrenergic receptor coupled with protein kinase A - cAMP response element binding protein (PKA-CREB) and Src-tyrosine kinase - glycogen synthase kinase-3beta (Src-GSK-3beta).	Norepinephrine	0-13	glycogen synthase kinase 3 beta	Homo sapiens	216-246
20595783-0	2010	Noradrenaline induces clock gene Per1 mRNA expression in C6 glioma cells through beta(2)-adrenergic receptor coupled with protein kinase A - cAMP response element binding protein (PKA-CREB) and Src-tyrosine kinase - glycogen synthase kinase-3beta (Src-GSK-3beta).	Norepinephrine	0-13	glycogen synthase kinase 3 beta	Homo sapiens	252-261
20595783-2	2010	To evaluate involvement of noradrenergic systems in regulation of circadian variation of clock-genes in astrocytes, we investigated effects of noradrenaline (NA) on expression of several clock genes in C6 glioma cells by using real-time PCR analysis.	Norepinephrine	143-156	clock circadian regulator	Homo sapiens	187-192
20150881-0	2010	Norepinephrine modulates the effect of neuropeptides in coeliac ganglion on ovarian hormones release: its relationship with ovarian nitric oxide and nerve growth factor.	Norepinephrine	0-14	nerve growth factor	Rattus norvegicus	149-168
19598006-1	2009	Thyroid hormones are known to stimulate thermogenesis in rodents by exerting a permissive effect on norepinephrine that affects uncoupling protein-1 (UCP1) expression in brown adipose tissue (BAT).	Norepinephrine	100-114	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	128-154
19524113-0	2009	Noradrenaline reduces the ATP-stimulated phosphorylation of p38 MAP kinase via beta-adrenergic receptors-cAMP-protein kinase A-dependent mechanism in cultured rat spinal microglia.	Norepinephrine	0-13	mitogen activated protein kinase 14	Rattus norvegicus	60-63
19299808-5	2009	Norepinephrine (NE) was continuously administered to patients who demonstrated a decrease in mean arterial blood pressure below 60 mm Hg after induction of EDA (EDA-NE group).	Norepinephrine	0-14	ectodysplasin A	Homo sapiens	156-159
19299808-5	2009	Norepinephrine (NE) was continuously administered to patients who demonstrated a decrease in mean arterial blood pressure below 60 mm Hg after induction of EDA (EDA-NE group).	Norepinephrine	0-14	ectodysplasin A	Homo sapiens	161-173
19212675-2	2009	By microarray expression analysis (Affymetrix HU133A) important players in the noradrenalin biosynthesis pathway (DBH, DDC, GATA2, GATA3, PHOX2A, PHOX2B, SLC6A2 SLC18A1 and TH) were found to be among the top ranked genes in showing lower expression in unfavorable NB tumor types as compared to favorable ones.	Norepinephrine	79-91	GATA binding protein 2	Homo sapiens	124-129
19212675-2	2009	By microarray expression analysis (Affymetrix HU133A) important players in the noradrenalin biosynthesis pathway (DBH, DDC, GATA2, GATA3, PHOX2A, PHOX2B, SLC6A2 SLC18A1 and TH) were found to be among the top ranked genes in showing lower expression in unfavorable NB tumor types as compared to favorable ones.	Norepinephrine	79-91	solute carrier family 18 member A1	Homo sapiens	161-168
18818287-8	2009	At night the pineal gland is adrenergically stimulated by release of norepinephrine from the sympathetic innervation; here, we found that treatment with adrenergic agonists suppresses pineal Pax4 expression in vivo and in vitro.	Norepinephrine	69-83	paired box 4	Homo sapiens	191-195
18818287-9	2009	This suppression appears to be mediated by cAMP, a second messenger of norepinephrine in the pineal gland, based on the observation that treatment with a cAMP mimic reduces pineal Pax4 mRNA levels.	Norepinephrine	71-85	paired box 4	Homo sapiens	180-184
18976638-3	2009	Emerging evidence indicates that brain noradrenergic systems contribute to the symptoms of mood disorders and may involve regulation of tyrosine hydroxylase (TH) expression, the rate-limiting enzyme in the biosynthesis of dopamine, norepinephrine and epinephrine.	Norepinephrine	232-246	tyrosine hydroxylase	Rattus norvegicus	136-156
18976638-3	2009	Emerging evidence indicates that brain noradrenergic systems contribute to the symptoms of mood disorders and may involve regulation of tyrosine hydroxylase (TH) expression, the rate-limiting enzyme in the biosynthesis of dopamine, norepinephrine and epinephrine.	Norepinephrine	232-246	tyrosine hydroxylase	Rattus norvegicus	158-160
18983636-1	2009	The aim of this study was to investigate the effect of low-intensity resistance exercise with slow lifting and lowering (LSL) on plasma endothelin-1 (ET-1) and noradrenalin concentrations in young healthy adults.	Norepinephrine	160-172	LEPQTL1	Homo sapiens	121-124
19122447-1	2009	BACKGROUND AND AIMS: Neuropeptide Y (NPY) is a sympathetic neurotransmitter co-stored and co-released with noradrenaline and adrenaline.	Norepinephrine	107-120	neuropeptide Y	Mus musculus	21-35
19122447-1	2009	BACKGROUND AND AIMS: Neuropeptide Y (NPY) is a sympathetic neurotransmitter co-stored and co-released with noradrenaline and adrenaline.	Norepinephrine	107-120	neuropeptide Y	Mus musculus	37-40
18682267-1	2008	We previously reported that endothelin-1 and endothelin-3 modulate norepinephrine neuronal release and tyrosine hydroxylase activity and expression in the hypothalamus.	Norepinephrine	67-81	endothelin 3	Rattus norvegicus	45-57
18682267-3	2008	Results showed that in the anterior hypothalamus endothelin-3 increased neuronal norepinephrine uptake whereas endothelin-1 decreased it.	Norepinephrine	81-95	endothelin 3	Rattus norvegicus	49-61
18789919-4	2008	The adenosine analogue, 2-chloroadenosine, inhibited noradrenaline-stimulated lipolysis and cAMP accumulation in A1R (+/+), but not in A1R (-/-) adipocytes.	Norepinephrine	53-66	adenosine A1 receptor	Mus musculus	113-116
18652859-1	2008	Monoamine oxidases (MAOs) A and B are mitochondrial bound isoenzymes which catalyze the oxidative deamination of dietary amines and monoamine neurotransmitters, such as serotonin, norepinephrine, dopamine, beta-phenylethylamine and other trace amines.	Norepinephrine	180-194	monoamine oxidase A	Mus musculus	0-33
18552869-1	2008	BACKGROUND AND PURPOSE: This study investigated whether deletion of the alpha1A-adrenoceptor gene influences contractile responses of mouse prostate to noradrenaline.	Norepinephrine	152-165	adrenergic receptor, alpha 1a	Mus musculus	72-92
18552869-2	2008	Responses of mouse prostate to noradrenaline are known to be mediated by alpha1L-adrenoceptors, which are thought to be a functional phenotype of alpha1A-adrenoceptor.	Norepinephrine	31-44	adrenergic receptor, alpha 1a	Mus musculus	146-166
18840973-2	2008	They include transporters for norepinephrine, dopamine and serotonin, which are encoded by the SLC6A2, SLC6A3, and SLC6A4 genes, respectivily.	Norepinephrine	30-44	solute carrier family 6 member 4	Canis lupus familiaris	115-121
18485637-0	2008	Evidence that geniposide abrogates norepinephrine-induced hypopigmentation by the activation of GLP-1R-dependent c-kit receptor signaling in melanocyte.	Norepinephrine	35-49	glucagon like peptide 1 receptor	Homo sapiens	96-102
18349382-1	2008	Phenylethanolamine N-methyltransferase (PNMT) catalyzes the synthesis of epinephrine from norepinephrine.	Norepinephrine	90-104	phenylethanolamine N-methyltransferase	Homo sapiens	0-38
18349382-1	2008	Phenylethanolamine N-methyltransferase (PNMT) catalyzes the synthesis of epinephrine from norepinephrine.	Norepinephrine	90-104	phenylethanolamine N-methyltransferase	Homo sapiens	40-44
18177483-0	2008	Chronic noradrenaline increases renal expression of NHE-3, NBC-1, BSC-1 and aquaporin-2.	Norepinephrine	8-21	solute carrier family 9 member A3	Rattus norvegicus	52-57
18177483-11	2008	Noradrenaline did significantly, but modestly (less than twofold), increase aquaporin-1 in the inner stripe of the outer medulla.	Norepinephrine	0-13	aquaporin 1	Rattus norvegicus	76-87
18177483-13	2008	We conclude that noradrenaline-induced increases in the expression of NHE-3, NBC-1, BSC-1 and aquaporin-2 are likely to play an important role in the regulation of salt and water transport by noradrenaline in the kidney and may explain, at least in part, the altered renal sodium and water handling associated with overactivation of the sympathetic system.	Norepinephrine	17-30	solute carrier family 9 member A3	Rattus norvegicus	70-75
18256599-5	2008	The cyclical release of HSCs and expression of Cxcl12 are regulated by core genes of the molecular clock through circadian noradrenaline secretion by the sympathetic nervous system.	Norepinephrine	123-136	chemokine (C-X-C motif) ligand 12	Mus musculus	47-53
18046021-11	2008	L-NAME (0.3 mM) reduced angiotensin II-mediated facilitation of norepinephrine release in nNOS(-/-) and wild-type mice but not in eNOS(-/-) mice.	Norepinephrine	64-78	nitric oxide synthase 1, neuronal	Mus musculus	90-94
18024547-9	2008	Importantly, a 2-wk administration of ghrelin dramatically suppressed the MI-induced increase in heart rate and plasma norepinephrine concentration to the similar levels as in sham-operated controls.	Norepinephrine	119-133	ghrelin and obestatin prepropeptide	Rattus norvegicus	38-45
17975121-3	2008	METHODS AND RESULTS: Norepinephrine and epinephrine, added to aortic smooth muscle cells (ASMCs) in vitro, altered Per1, E4bp4, and dbp expression and altered the observed oscillations in clock gene expression.	Norepinephrine	21-35	nuclear factor, interleukin 3, regulated	Mus musculus	121-126
18257750-21	2008	administration of CDP-choline or its cholinergic metabolites phosphocholine and choline increases plasma adrenaline and noradrenaline concentrations by enhancing nicotinic cholinergic neurotransmission in the sympatho-adrenal system.	Norepinephrine	120-133	cut like homeobox 1	Homo sapiens	18-21
17295024-1	2007	Activation of either coexisting beta1- or beta2 -adrenoceptors with noradrenaline or adrenaline, respectively, causes maximum increases of contractility of human atrial myocardium.	Norepinephrine	68-81	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	42-47
17207896-4	2007	The aim of the present study was to determine the interaction between NPY and IL-1beta in catecholamine (norepinephrine, NE and epinephrine, EP) release from mouse chromaffin cells in culture.	Norepinephrine	105-119	neuropeptide Y	Mus musculus	70-73
17982884-8	2007	We also found that the activities and/or the levels of the mRNA and protein of aromatic L-amino acid decarboxylase (AADC, DOPA decarboxylase), DBH, phenylethanolamine N-methyltransferase (PNMT), which synthesize dopamine, noradrenaline, and adrenaline, respectively, were also decreased in PD brains, indicating that all catecholamine systems were widely impaired in PD brains.	Norepinephrine	222-235	phenylethanolamine N-methyltransferase	Homo sapiens	148-186
17243640-4	2007	In the present reviews, I focused on the role of orexin on the norepinephrine and acetylcholine arousal system during anesthesia, the autonomic/endocrine regulation and pain pathways.	Norepinephrine	63-77	hypocretin neuropeptide precursor	Homo sapiens	49-55
17014930-0	2007	Norepinephrine acts as D1-dopaminergic agonist in the embryonic avian retina: late expression of beta1-adrenergic receptor shifts norepinephrine specificity in the adult tissue.	Norepinephrine	130-144	adrenoceptor beta 3	Gallus gallus	97-122
17228259-5	2007	CONCLUSION: Our findings suggest that CPP elevation induced by norepinephrine is effective in improving contusional rCBF only in selected cases, which are represented by a subset of contusions with critical perfusion, which can be identified by rCBF measurements.	Norepinephrine	63-77	CCAAT/enhancer binding protein zeta	Rattus norvegicus	116-120
17228259-5	2007	CONCLUSION: Our findings suggest that CPP elevation induced by norepinephrine is effective in improving contusional rCBF only in selected cases, which are represented by a subset of contusions with critical perfusion, which can be identified by rCBF measurements.	Norepinephrine	63-77	CCAAT/enhancer binding protein zeta	Rattus norvegicus	245-249
16889765-9	2006	The comitogen, norepinephrine (NE), increased the proliferative response to EGF to the same extent in both fresh and CP rat hepatocytes.	Norepinephrine	15-29	epidermal growth factor like 1	Rattus norvegicus	76-79
16650497-9	2006	The results show that TH and AGT mRNA expression changes during the different phases of experimental hypertension, suggesting that the noradrenaline (NOR) and angiotensin II (Ang II) might participate in the modulation/maintenance of coarctation hypertension.	Norepinephrine	135-148	tyrosine hydroxylase	Rattus norvegicus	22-24
16764338-0	2006	The norepinephrine level is decreased in the lymphocytes of long-term interferon-beta-treated multiple sclerosis patients.	Norepinephrine	4-18	interferon beta 1	Homo sapiens	70-85
16554048-3	2006	We employed a norepinephrine uptake assay using SH-SY5Y cells and found that the IP3 receptor inhibitors, 2-aminoethoxydiphenyl borate and xestospongin C, reduced the NET Vmax.	Norepinephrine	14-28	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	81-93
16564429-5	2006	Noradrenaline, a neurotransmitter believed to play an immunosupressive role in neuroinflammatory disorders, is catabolized by catechol-O-methyl transferase (COMT).	Norepinephrine	0-13	catechol-O-methyltransferase	Homo sapiens	126-155
16564429-5	2006	Noradrenaline, a neurotransmitter believed to play an immunosupressive role in neuroinflammatory disorders, is catabolized by catechol-O-methyl transferase (COMT).	Norepinephrine	0-13	catechol-O-methyltransferase	Homo sapiens	157-161
16505231-1	2006	AMP-activated protein kinase (AMPK), which functions as a sensor of cellular energy homeostasis, was phosphorylated after norepinephrine stimulation in L6 skeletal muscle cells.	Norepinephrine	122-136	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	0-28
16505231-1	2006	AMP-activated protein kinase (AMPK), which functions as a sensor of cellular energy homeostasis, was phosphorylated after norepinephrine stimulation in L6 skeletal muscle cells.	Norepinephrine	122-136	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	30-34
16380518-7	2006	As compared with saline, nerve growth factor refilled depleted cardiac norepinephrine stores and improved cardiac [3H]-norepinephrine uptake into isolated perfused hearts of transverse aortic constricted rats.	Norepinephrine	119-133	nerve growth factor	Rattus norvegicus	25-44
16380518-11	2006	In conclusion, nerve growth factor attenuates local cardiac sympathetic overdrive of hypertrophic hearts by improving cardiac norepinephrine reuptake and might represent a novel therapeutic principle in the treatment of heart failure.	Norepinephrine	126-140	nerve growth factor	Rattus norvegicus	15-34
16233957-1	2006	Based on their metabolic inactivation of dopamine and norepinephrine, genes encoding the catechol-O-methyltransferase (COMT) enzyme are appropriate candidates to consider in the pathogenesis of schizophrenia.	Norepinephrine	54-68	catechol-O-methyltransferase	Homo sapiens	89-117
16233957-1	2006	Based on their metabolic inactivation of dopamine and norepinephrine, genes encoding the catechol-O-methyltransferase (COMT) enzyme are appropriate candidates to consider in the pathogenesis of schizophrenia.	Norepinephrine	54-68	catechol-O-methyltransferase	Homo sapiens	119-123
16428474-12	2006	Norepinephrine also increased tumor cell expression of MMP-2 (P = 0.02 for both SKOV3 and EG cells) and MMP-9 (P = 0.01 and 0.04, respectively), and pharmacologic blockade of MMPs abrogated the effects of norepinephrine on tumor cell invasive potential.	Norepinephrine	0-14	matrix metallopeptidase 2	Homo sapiens	55-60
16428474-12	2006	Norepinephrine also increased tumor cell expression of MMP-2 (P = 0.02 for both SKOV3 and EG cells) and MMP-9 (P = 0.01 and 0.04, respectively), and pharmacologic blockade of MMPs abrogated the effects of norepinephrine on tumor cell invasive potential.	Norepinephrine	0-14	matrix metallopeptidase 2	Homo sapiens	175-179
16225854-2	2006	METHODS: The positive inotropic effects of noradrenaline (in the presence of the beta2-selective antagonist ICI118551) and adrenaline (in the presence of the beta1-selective antagonist CGP20712), mediated through beta1- and beta2-adrenoceptors, respectively, were investigated in atrial and ventricular trabeculae.	Norepinephrine	43-56	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	81-86
16225854-2	2006	METHODS: The positive inotropic effects of noradrenaline (in the presence of the beta2-selective antagonist ICI118551) and adrenaline (in the presence of the beta1-selective antagonist CGP20712), mediated through beta1- and beta2-adrenoceptors, respectively, were investigated in atrial and ventricular trabeculae.	Norepinephrine	43-56	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	224-229
17201629-4	2006	That catechin-polyphenols are known to be capable of inhibiting catechol-O-methyltransferase (the enzyme that degrades norepinephrine) is a possible explanation for why the green tea extract is effective in stimulating thermogenesis by epigallocatechin gallate to augment and prolong sympathetic stimulation of thermogenesis.	Norepinephrine	119-133	catechol-O-methyltransferase	Homo sapiens	64-92
16479149-2	2006	The accessory beta(3) subunits of Ca(2+) channels (Ca(V)beta(3)) are preferentially associated with the alpha(1B) subunit to form N-type Ca(2+) channels, and are therefore expected to play a functional role in the stimulation-evoked release of noradrenaline.	Norepinephrine	244-257	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	51-63
15914506-10	2005	Both epinephrine and norepinephrine reduced insulin-stimulated GLUT4 translocation to the plasma membrane.	Norepinephrine	21-35	solute carrier family 2 member 4	Homo sapiens	63-68
16148610-11	2005	A potential interaction consists in a reduction of vascular noradrenaline sensitivity, which can be considered as a class effect of AT1 antagonists at high dosage.	Norepinephrine	60-73	angiotensin II receptor, type 1a	Rattus norvegicus	132-135
15894566-9	2005	Notably, rAdv.heNOS decreased plasma levels of norepinephrine and plasma renin activity in cold-exposed rats, which suggests that eNOS gene transfer may decrease the activities of the sympathetic nervous system and the renin-angiotensin system.	Norepinephrine	47-61	renin	Rattus norvegicus	219-224
15961351-8	2005	ELISA results illustrate that norepinephrine significantly increases PEDF secretion by RPE cells and propranolol slightly decreases PEDF secretion into RPE cell medium.	Norepinephrine	30-44	serpin family F member 1	Rattus norvegicus	69-73
15961351-10	2005	Furthermore, expression of PEDF was significantly increased after treatment of norepinephrine in RPE medium demonstrating a role of beta-adrenergic regulation of PEDF.	Norepinephrine	79-93	serpin family F member 1	Rattus norvegicus	27-31
15961351-10	2005	Furthermore, expression of PEDF was significantly increased after treatment of norepinephrine in RPE medium demonstrating a role of beta-adrenergic regulation of PEDF.	Norepinephrine	79-93	serpin family F member 1	Rattus norvegicus	162-166
15908512-7	2005	In the presence of alphaAR blockade, concentration-response curves for isoproterenol, norepinephrine, and epinephrine suggested that a beta1AR was involved in this response, and the rank order of potency was isoproterenol &gt; norepinephrine = epinephrine.	Norepinephrine	86-100	adrenoceptor beta 1	Homo sapiens	135-142
15908512-7	2005	In the presence of alphaAR blockade, concentration-response curves for isoproterenol, norepinephrine, and epinephrine suggested that a beta1AR was involved in this response, and the rank order of potency was isoproterenol &gt; norepinephrine = epinephrine.	Norepinephrine	227-241	adrenoceptor beta 1	Homo sapiens	135-142
16195872-0	2005	Cannabinoid CB1 receptor-mediated inhibition of noradrenaline release in guinea-pig vessels, but not in rat and mouse aorta.	Norepinephrine	48-61	cannabinoid receptor 1 (brain)	Mus musculus	12-15
15927391-1	2005	Catechol-O-methyltransferase (COMT) inactivates dopamine, epinephrine and norepinephrine in the nervous system.	Norepinephrine	74-88	catechol-O-methyltransferase	Homo sapiens	0-28
15927391-1	2005	Catechol-O-methyltransferase (COMT) inactivates dopamine, epinephrine and norepinephrine in the nervous system.	Norepinephrine	74-88	catechol-O-methyltransferase	Homo sapiens	30-34
15834289-1	2005	OBJECTIVE: To test the hypothesis that the enhanced vascular responsiveness to norepinephrine that occurs during deoxycorticosterone acetate (DOCA)-salt induced hypertension is causally related to increased expression of cyclo-oxygenase (COX)-2 and oxidative stress, which diminishes the vasomodulatory influence of endothelium-derived nitric oxide.	Norepinephrine	79-93	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	221-244
15834289-10	2005	CONCLUSIONS: COX-2 expression increases during DOCA-salt hypertension, and mediates production of factors that enhance rat aortic contractility in response to norepinephrine.	Norepinephrine	159-173	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	13-18
15834289-11	2005	Our data also suggest a role for increased oxidative stress, which is at least in part dependent on enhanced COX-2 expression, in the mechanism(s) of enhanced aortic contractility in response to norepinephrine during DOCA-salt hypertension.	Norepinephrine	195-209	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	109-114
15795312-5	2005	The RyR antagonists ruthenium red, ryanodine, tetracaine, and dantrolene greatly inhibited submaximal noradrenaline- and hypoxia-induced Ca2+ release and contraction in freshly isolated rat PASMCs, but did not affect ATP-induced Ca2+ release in cultured human PASMCs.	Norepinephrine	102-115	ryanodine receptor 2	Rattus norvegicus	4-7
15523499-1	2005	The beta-adrenergic receptors (beta-AR) are G protein-coupled receptors activated by epinephrine and norepinephrine and are involved in a variety of their physiological functions.	Norepinephrine	101-115	adrenoceptor beta 1	Homo sapiens	31-38
15582720-1	2005	The aim of the present study was to assess whether calcitonin gene-related peptide (CGRP) modulates exocytotic norepinephrine release in ischemic myocardium.	Norepinephrine	111-125	calcitonin-related polypeptide alpha	Rattus norvegicus	51-82
15691884-1	2005	Type II 5" deiodinase (D2) activity produces triiodothyronine (T3) from thyroxine (T4) and is induced by cold and norepinephrine (NE) in brown adipose tissue.	Norepinephrine	114-128	iodothyronine deiodinase 2	Rattus norvegicus	0-21
16034680-9	2005	However, mRNA levels of uncoupling protein 1 (UCP1), a heat generating protein, as well as plasma norepinephrine levels, were higher in SAMP1 than in SAMR1 mice.	Norepinephrine	98-112	transmembrane protein 201	Mus musculus	136-141
15720475-4	2005	It is suggested that activation of GnRH/LH release in the VMH/NI of anoestrous ewes may result from a decrease of norepinephrine output and hence its inhibitory effect on GnRH secretion.	Norepinephrine	114-128	gonadotropin releasing hormone 1	Homo sapiens	35-39
15452383-8	2005	The AT1 receptor antagonist EXP3174 (0.1 microM) blocked Ang I- and II-induced renal vasoconstriction and noradrenaline release to RNS in both strains.	Norepinephrine	106-119	angiotensin II receptor, type 1a	Rattus norvegicus	4-7
15520843-1	2005	The catechol-O-methyltransferase (COMT) is a major degrading enzyme in the metabolic pathways of catecholaminergic neurotransmitters such as dopamine and norepinephrine.	Norepinephrine	154-168	catechol-O-methyltransferase	Homo sapiens	4-32
15520843-1	2005	The catechol-O-methyltransferase (COMT) is a major degrading enzyme in the metabolic pathways of catecholaminergic neurotransmitters such as dopamine and norepinephrine.	Norepinephrine	154-168	catechol-O-methyltransferase	Homo sapiens	34-38
15500961-8	2004	Epinephrine, norepinephrine and octopamine also weakly inhibited macroscopic currents at NR1/NR2A and NR1/NR2B receptors.	Norepinephrine	13-27	glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog	Xenopus laevis	93-97
15451776-0	2004	Sympathectomy reveals alpha 1A- and alpha 1D-adrenoceptor components to contractions to noradrenaline in rat vas deferens.	Norepinephrine	88-101	adrenoceptor alpha 1A	Rattus norvegicus	22-57
15451776-11	2004	The alpha(1D)-adrenoceptor is only detectable by ligand binding following chemical sympathectomy, but is involved in noradrenaline-evoked contractions, particularly phasic contractions, of rat vas deferens.	Norepinephrine	117-130	adrenoceptor alpha 1D	Rattus norvegicus	4-26
15297444-2	2004	Norepinephrine (NE), the endogenous neurotransmitter, dose-dependently increased the levels of phosphorylated MAPK kinase 3/6 (MKK3/6) and p38MAPK in rat pinealocytes.	Norepinephrine	0-14	mitogen activated protein kinase kinase 3	Rattus norvegicus	127-134
15124004-1	2004	The enzyme catechol-o-methyltransferase (COMT) transfers a methyl group from adenosylmethionine to catecholamines including the neurotransmitters dopamine, epinephrine and norepinephrine.	Norepinephrine	172-186	catechol-O-methyltransferase	Homo sapiens	11-39
15124004-1	2004	The enzyme catechol-o-methyltransferase (COMT) transfers a methyl group from adenosylmethionine to catecholamines including the neurotransmitters dopamine, epinephrine and norepinephrine.	Norepinephrine	172-186	catechol-O-methyltransferase	Homo sapiens	41-45
15245872-1	2004	We have previously reported that endothelin 1 and 3 (ET-1, ET-3) through the ETB receptor decrease norepinephrine release in the anterior hypothalamus and activate the nitric oxide (NO) pathway.	Norepinephrine	99-113	endothelin receptor type B	Rattus norvegicus	77-80
15201706-11	2004	Infusion of higher doses of the EP4 agonist at 3 and 10 microg/kg/h attenuated LPS-induced hypotension and hyporeactivity to norepinephrine.	Norepinephrine	125-139	prostaglandin E receptor 4	Rattus norvegicus	32-35
15141807-2	2004	OBJECTIVES: This study was aimed at the evaluation of the effect of selective COX-2 inhibitor meloxicam on vasoconstrictor responses to noradrenaline (NA) in rabbit renal artery chosen as a model vessel and in rabbit ear artery as a peripheral artery under in vitro conditions.	Norepinephrine	136-149	cytochrome c oxidase subunit II	Oryctolagus cuniculus	78-83
14732211-0	2004	Norepinephrine induces apoptosis in neonatal rat endothelial cells via down-regulation of Bcl-2 and activation of beta-adrenergic and caspase-2 pathways.	Norepinephrine	0-14	caspase 2	Rattus norvegicus	134-143
15583474-4	2004	The expression of TH mRNA and the concentration of adrenomedullary epinephrine and norepinephrine were also lower in transgenic mice when compared with wild-type controls.	Norepinephrine	83-97	tyrosine hydroxylase	Mus musculus	18-20
15207357-2	2004	The alpha2C-adrenoceptor (alpha2C-AR) is present on axon terminals in this nucleus and therefore norepinephrine is likely to modulate input to LSN neurons.	Norepinephrine	97-111	adrenoceptor alpha 2C	Rattus norvegicus	4-24
15207357-2	2004	The alpha2C-adrenoceptor (alpha2C-AR) is present on axon terminals in this nucleus and therefore norepinephrine is likely to modulate input to LSN neurons.	Norepinephrine	97-111	adrenoceptor alpha 2C	Rattus norvegicus	26-36
14871027-5	2003	Cyclooxygenase-1 inhibitors (flurbiprofen, 10(-7) M) attenuated the noradrenaline-induced contraction and cyclooxygenase-2 (nimesulide, 10(-7) M) slightly attenuated the contraction.	Norepinephrine	68-81	prostaglandin-endoperoxide synthase 1	Rattus norvegicus	0-16
14871027-7	2003	Based on these results, it was suggested that the contraction induced by noradrenaline in the rat coronary artery in the presence of L-NAME and arachidonic acid is endothelium-dependent, and that it involves reactive oxygen species and endothelial cyclooxygenase-1 metabolites of arachidonic acid.	Norepinephrine	73-86	prostaglandin-endoperoxide synthase 1	Rattus norvegicus	248-264
15314382-10	2003	CONCLUSION: The SP-6 acupressure reduced the subjective perception of dysmenorrhea and the levels of norepinephrine.	Norepinephrine	101-115	Sp6 transcription factor	Homo sapiens	16-20
14581168-1	2003	The contaminants in deionized and distilled water (DDI water) boiled with polystyrene resin inhibited A-type monoamine oxidase (MAO, MAO-A preferentially deaminates serotonin and norepinephrine and regulates these amines concentration) activity in monkey brain mitochondria.	Norepinephrine	179-193	monoamine oxidase A	Rattus norvegicus	128-131
14581168-1	2003	The contaminants in deionized and distilled water (DDI water) boiled with polystyrene resin inhibited A-type monoamine oxidase (MAO, MAO-A preferentially deaminates serotonin and norepinephrine and regulates these amines concentration) activity in monkey brain mitochondria.	Norepinephrine	179-193	monoamine oxidase A	Rattus norvegicus	133-138
14581168-7	2003	These results indicate that zinc benzoate, which inhibits MAO-A activity, is easily incorporated in DDI water by boiling polystyrene and also may be a contaminating environmental chemical compound that alters the levels of serotonin and norepinephrine in the central nervous system.	Norepinephrine	237-251	monoamine oxidase A	Rattus norvegicus	58-63
12855600-7	2003	CGRP (10(-10)--10(-7) M) produced a concentration-dependent relaxation of norepinephrine-induced contractions in both NP-DE and Day 18 pregnant rat uterine arteries.	Norepinephrine	74-88	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
14512028-9	2003	Our data suggest that HAND2 regulates cell type-specific expression of norepinephrine in concert with Phox2a by a novel mechanism.	Norepinephrine	71-85	paired like homeobox 2A	Homo sapiens	102-108
14520117-2	2003	Catechol-O-methyltransferase and monoamine oxidase enzymes are important agents in the metabolic inactivation of these neurotransmitters (ie, dopamine, serotonin, and norepinephrine).	Norepinephrine	167-181	catechol-O-methyltransferase	Homo sapiens	0-28
12724349-7	2003	Norepinephrine also activates several transcriptional reporters through alpha1A-adrenergic receptors in PC12 cells, including reporters for activator protein 1, serum response element, cAMP response element, nuclear factor-kappaB, nuclear factor of activated T cells, gamma-interferon-activated sequence, and signal transducer and activator of transcription.	Norepinephrine	0-14	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	140-159
12749888-1	2003	Predominance in the urethra and prostate of the alpha(1A)-adrenoceptor subtype, which is believed to be the receptor mediating noradrenaline induced smooth muscle contraction in these tissues, led to the preparation of alpha(1A)-selective antagonists to be tested as uroselective compounds for the treatment of benign prostatic hyperplasia.	Norepinephrine	127-140	adrenoceptor alpha 1A	Canis lupus familiaris	48-70
12749888-1	2003	Predominance in the urethra and prostate of the alpha(1A)-adrenoceptor subtype, which is believed to be the receptor mediating noradrenaline induced smooth muscle contraction in these tissues, led to the preparation of alpha(1A)-selective antagonists to be tested as uroselective compounds for the treatment of benign prostatic hyperplasia.	Norepinephrine	127-140	adrenoceptor alpha 1A	Canis lupus familiaris	48-56
12746308-4	2003	Elevated nocturnal levels of Aa-nat mRNA were strongly suppressed following light exposure or adrenergic antagonist administration, demonstrating the involvement of norepinephrine in the stimulation of melatonin synthesis.	Norepinephrine	165-179	serotonin N-acetyltransferase	Mesocricetus auratus	29-35
12729939-1	2003	Angiotensin-converting enzyme (ACE) modulates dopamine turnover in the brain and catechol-O-methyltransferase (COMT) enzyme is an important agent in the metabolic inactivation of dopamine and norepinephrine.	Norepinephrine	192-206	catechol-O-methyltransferase	Homo sapiens	81-109
12729939-1	2003	Angiotensin-converting enzyme (ACE) modulates dopamine turnover in the brain and catechol-O-methyltransferase (COMT) enzyme is an important agent in the metabolic inactivation of dopamine and norepinephrine.	Norepinephrine	192-206	catechol-O-methyltransferase	Homo sapiens	111-115
28853928-8	2003	The reduced locomotor activity of Gdnf +/- mice was accompanied by reductions in NE transporter activity in the cerebellum and brain stem as well as decreased norepinephrine tissue levels in the LC.	Norepinephrine	159-173	glial cell line derived neurotrophic factor	Mus musculus	34-38
12609750-2	2003	Ang II stimulates norepinephrine (NE), epinephrine (EP) and NPY release from perifused chromaffin cells by 3-, 2- and 12-fold, respectively.	Norepinephrine	18-32	angiogenin	Homo sapiens	0-3
12618232-9	2003	CONCLUSION: These findings suggest that norepinephrine-induced hypertrophy is linked closely with p38 MAP kinase activation, which can be endogenously modulated through estrogen-responsive regulation of MKP-1 expression.	Norepinephrine	40-54	mitogen-activated protein kinase 14	Mus musculus	98-101
12668889-1	2003	Human BNP serves to compensate for deteriorating cardiac function causing preload and afterload reductions, natriuresis, diuresis, suppression of the renin-angiotensin-aldosterone system (RAAS) and endothelin-1, and lowering of norepinephrine.	Norepinephrine	228-242	natriuretic peptide B	Homo sapiens	6-9
12616336-1	2003	Two forms of the activated beta1-adrenoceptor exist, one that is stabilized by (-)-noradrenaline and is sensitive to blockade by (-)-propranolol and another which is stabilized by partial agonists such as (-)-pindolol and (-)-CGP 12177 but is relatively insensitive to (-)-propranolol.	Norepinephrine	79-96	adrenoceptor beta 1	Homo sapiens	27-45
12450575-2	2002	We have found that cannabidiol can also interact with cannabinoid CB(1) receptor agonists in the mouse vas deferens, a tissue in which prejunctional cannabinoid CB(1) receptors mediate inhibition of electrically evoked contractions by suppressing noradrenaline and/or ATP release.	Norepinephrine	247-260	cannabinoid receptor 1 (brain)	Mus musculus	66-71
12450575-2	2002	We have found that cannabidiol can also interact with cannabinoid CB(1) receptor agonists in the mouse vas deferens, a tissue in which prejunctional cannabinoid CB(1) receptors mediate inhibition of electrically evoked contractions by suppressing noradrenaline and/or ATP release.	Norepinephrine	247-260	cannabinoid receptor 1 (brain)	Mus musculus	161-166
12446017-5	2002	A positive association between plasma norepinephrine levels and MMP-2 protein levels, and a negative correlation between plasma cortisol levels and MMP-2 levels were found.	Norepinephrine	38-52	matrix metallopeptidase 2	Homo sapiens	64-69
12383575-0	2002	Conservation of the cardiostimulant effects of (-)-norepinephrine across Ser49Gly and Gly389Arg beta(1)-adrenergic receptor polymorphisms in human right atrium in vitro.	Norepinephrine	47-65	adrenoceptor beta 1	Homo sapiens	96-123
12383575-1	2002	OBJECTIVE: The goal of this study was to determine whether the cardiostimulant effects of the endogenous beta(1)-adrenergic receptor (AR) agonist, (-)-norepinephrine are modified by polymorphic (Serine49Glycine [Ser49Gly], Glycine389Arginine [Gly389Arg]) variants of beta(1)-ARs in the nonfailing adult human heart.	Norepinephrine	147-165	adrenoceptor beta 1	Homo sapiens	105-132
12383575-1	2002	OBJECTIVE: The goal of this study was to determine whether the cardiostimulant effects of the endogenous beta(1)-adrenergic receptor (AR) agonist, (-)-norepinephrine are modified by polymorphic (Serine49Glycine [Ser49Gly], Glycine389Arginine [Gly389Arg]) variants of beta(1)-ARs in the nonfailing adult human heart.	Norepinephrine	147-165	adrenoceptor beta 1	Homo sapiens	134-136
12364464-8	2002	There were significant correlations between c-PTHrP levels and plasma norepinephrine, brain natriuretic peptide, angiotensin II, and endothelin-1 levels.	Norepinephrine	70-84	parathyroid hormone like hormone	Homo sapiens	44-51
12084707-7	2002	Additionally, Western blot analysis for phospho-CREB/ATF1 shows an increase in phosphorylation of CREB/ATF1 in HIB-1B cells after norepinephrine treatment.	Norepinephrine	130-144	activating transcription factor 1	Mus musculus	103-107
12205187-10	2002	These data demonstrate that the VR1 receptor appears to be located presynaptically on afferents to the LC, and that activation of VR1 may serve to potentiate the release of glutamate and adrenaline/noradrenaline in this brain region.	Norepinephrine	198-211	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	32-35
12205187-10	2002	These data demonstrate that the VR1 receptor appears to be located presynaptically on afferents to the LC, and that activation of VR1 may serve to potentiate the release of glutamate and adrenaline/noradrenaline in this brain region.	Norepinephrine	198-211	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	130-133
12130713-1	2002	We recently reported that in the ischemic human heart, locally formed angiotensin II activates angiotensin II type 1 (AT(1)) receptors on sympathetic nerve terminals, promoting reversal of the norepinephrine transporter in an outward direction (i.e., carrier-mediated norepinephrine release).	Norepinephrine	193-207	angiotensin II receptor type 1	Homo sapiens	95-123
11943777-1	2002	The homeodomain transcription factor Arix/Phox2a plays a critical role in the specification of noradrenergic neurons by inducing the expression of dopamine beta-hydroxylase (DBH), the terminal enzyme for noradrenaline biosynthesis.	Norepinephrine	204-217	paired like homeobox 2A	Homo sapiens	37-41
11943777-1	2002	The homeodomain transcription factor Arix/Phox2a plays a critical role in the specification of noradrenergic neurons by inducing the expression of dopamine beta-hydroxylase (DBH), the terminal enzyme for noradrenaline biosynthesis.	Norepinephrine	204-217	paired like homeobox 2A	Homo sapiens	42-48
11948255-0	2002	A direct role of the homeodomain proteins Phox2a/2b in noradrenaline neurotransmitter identity determination.	Norepinephrine	55-68	paired like homeobox 2A	Danio rerio	42-48
11953080-1	2002	OBJECTIVE: To study the distribution and levels of norepinephrine (NE) and dopamine (DA) in placenta tissues of normal pregnancy and pregnancy induced hypertension syndrome (PIH) and discuss the relationship of NE and DA with PIH.	Norepinephrine	51-65	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	174-177
11786145-5	2002	The neuromodulatory action of leptin (0.2 and 3 nM) on the overflow of noradrenaline and DHPG from the medulla and hypothalamus was examined.	Norepinephrine	71-84	leptin	Rattus norvegicus	30-36
11786145-7	2002	Administration of 0.2 and 3 nM leptin significantly increased medullary noradrenaline overflow to 172% and 174% of basal levels, respectively.	Norepinephrine	72-85	leptin	Rattus norvegicus	31-37
11931349-0	2002	Pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide-stimulated cyclic AMP synthesis in rat cerebral cortical slices: interaction with noradrenaline, adrenaline, and forskolin.	Norepinephrine	167-180	adenylate cyclase activating polypeptide 1	Rattus norvegicus	0-50
11819028-3	2002	Infusion of peptide YY (PYY; 1 microg/kg per min) strongly inhibited the stimulation-evoked overflow of noradrenaline and NPY-LI.	Norepinephrine	104-117	peptide YY	Sus scrofa	12-22
11914123-7	2002	The Src kinase inhibitors PP1 and PP2 partially diminished the ERK responses elicited by both norepinephrine and PGF2alpha.	Norepinephrine	94-108	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	34-37
12061021-2	2002	AIM: This study was aimed to evaluate the effect of drugs inhibiting both cyclooxygenase (COX) isoforms COX-1 and COX-2 on vasoconstrictor responses to noradrenaline in the rabbit renal artery and to compare these responses with femoral artery as a systemic vessel.	Norepinephrine	152-165	cytochrome c oxidase subunit II	Oryctolagus cuniculus	114-119
12210722-3	2002	Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of these biogenic amines (dopamine (DA), norepinephrine (NE), and epinephrine (EPI)).	Norepinephrine	120-134	tyrosine hydroxylase	Mus musculus	0-20
12210722-3	2002	Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of these biogenic amines (dopamine (DA), norepinephrine (NE), and epinephrine (EPI)).	Norepinephrine	120-134	tyrosine hydroxylase	Mus musculus	22-24
11684150-4	2001	Superfusion of noradrenaline produced a potentiation of action potential firing (AC channel) as well as a depression of the cumulative depolarisation (DC channel) in responses to repetitive afferent stimulation.Noradrenaline-induced potentiation of firing was mimicked by the alpha1A-adrenoceptor agonist A 61603 and the alpha1-adrenoceptor agonist methoxamine in a reversible and concentration-dependent manner.	Norepinephrine	15-28	adrenoceptor alpha 1A	Rattus norvegicus	276-296
11684150-4	2001	Superfusion of noradrenaline produced a potentiation of action potential firing (AC channel) as well as a depression of the cumulative depolarisation (DC channel) in responses to repetitive afferent stimulation.Noradrenaline-induced potentiation of firing was mimicked by the alpha1A-adrenoceptor agonist A 61603 and the alpha1-adrenoceptor agonist methoxamine in a reversible and concentration-dependent manner.	Norepinephrine	211-224	adrenoceptor alpha 1A	Rattus norvegicus	276-296
11684150-6	2001	The alpha(1A)-adrenoceptor antagonist 5-methyl-urapidil and the alpha1-adrenoceptor antagonist corynanthyne blocked the excitatory effects of noradrenaline.	Norepinephrine	142-155	adrenoceptor alpha 1A	Rattus norvegicus	4-26
11750790-1	2001	The availability of mutant mice that lack either MAO A or MAO B has created unique profiles in the central and peripheral availability of serotonin, norepinephrine, dopamine, and phenylethylamine.	Norepinephrine	149-163	monoamine oxidase A	Mus musculus	49-54
11682453-13	2001	In conclusion, the present functional data in the mouse suggest that (1) alpha(1D)-like adrenoceptors are present in the mesenteric artery, (2) there is the regional difference for the sensitivity for noradrenaline in the abdominal aorta and (3) noradrenaline evokes the contraction mediated through alpha(1D)-adrenoceptor in the upper abdominal aorta, whereas there is alpha(1A)-adrenoceptor-mediated contraction in the lower abdominal aorta.	Norepinephrine	201-214	adrenergic receptor, alpha 1d	Mus musculus	300-322
11682453-13	2001	In conclusion, the present functional data in the mouse suggest that (1) alpha(1D)-like adrenoceptors are present in the mesenteric artery, (2) there is the regional difference for the sensitivity for noradrenaline in the abdominal aorta and (3) noradrenaline evokes the contraction mediated through alpha(1D)-adrenoceptor in the upper abdominal aorta, whereas there is alpha(1A)-adrenoceptor-mediated contraction in the lower abdominal aorta.	Norepinephrine	201-214	adrenergic receptor, alpha 1a	Mus musculus	370-392
11606452-1	2001	Norepinephrine has long been known to stimulate the pulsatile and preovulatory release of LH-releasing hormone (LHRH).	Norepinephrine	0-14	gonadotropin releasing hormone 1	Homo sapiens	90-110
11606452-1	2001	Norepinephrine has long been known to stimulate the pulsatile and preovulatory release of LH-releasing hormone (LHRH).	Norepinephrine	0-14	gonadotropin releasing hormone 1	Homo sapiens	112-116
11774707-4	2001	The half-maximum effective concentration (EC50) of NAd was 1.7 x 10(-7) M, and the response was mimicked by an alpha 1-adrenoceptor agonist cirazoline and was inhibited by WB-4101, an alpha 1A-adrenoceptor antagonist.	Norepinephrine	51-54	adrenoceptor alpha 1A	Rattus norvegicus	184-205
11774707-5	2001	Oxymetazoline, a partial agonist for an alpha 1A-adrenoceptor, also evoked the inward current with an EC50 of 3.5 x 10(-8) M. The maximum current induced by oxymetazoline (10(-6) M) was 44% of that induced by NAd.	Norepinephrine	209-212	adrenoceptor alpha 1A	Rattus norvegicus	40-61
11701195-3	2001	Central administration of norepinephrine (NE) suppressed food intake with narcolepsy as GLP-1 in chicks.	Norepinephrine	26-40	glucagon	Gallus gallus	88-93
11264240-2	2001	This study was designed to assess the molecular and cellular events involved in the up-regulation (and receptor supersensitivity) of brain alpha(2)-adrenoceptors as a result of chronic depletion of noradrenaline (and other monoamines) by reserpine.	Norepinephrine	198-211	adrenoceptor alpha 2A	Rattus norvegicus	139-161
11165376-2	2001	Nerve growth factor (NGF) decreased [3H]-norepinephrine (NE) uptake in association with a decrease in NET mRNA levels.	Norepinephrine	41-55	nerve growth factor	Rattus norvegicus	0-19
11165376-2	2001	Nerve growth factor (NGF) decreased [3H]-norepinephrine (NE) uptake in association with a decrease in NET mRNA levels.	Norepinephrine	41-55	nerve growth factor	Rattus norvegicus	21-24
11141309-1	2001	Norepinephrine is N-methylated to epinephrine by the catalytic effect of the terminal enzyme in catecholamine biosynthesis, phenylethanolamine N-methyltransferase (PNMT).	Norepinephrine	0-14	phenylethanolamine N-methyltransferase	Homo sapiens	124-162
11141309-1	2001	Norepinephrine is N-methylated to epinephrine by the catalytic effect of the terminal enzyme in catecholamine biosynthesis, phenylethanolamine N-methyltransferase (PNMT).	Norepinephrine	0-14	phenylethanolamine N-methyltransferase	Homo sapiens	164-168
11179842-2	2000	The present study investigated the effect of repeated seizure experiences by acoustic stimulation (110 dB, 10 times) on the immunoreactivities of tyrosine hydroxylase (TH), a rate-determining enzyme in the synthesis of norepinephrine, in brain regions of GEPRs.	Norepinephrine	219-233	tyrosine hydroxylase	Rattus norvegicus	146-166
11179842-2	2000	The present study investigated the effect of repeated seizure experiences by acoustic stimulation (110 dB, 10 times) on the immunoreactivities of tyrosine hydroxylase (TH), a rate-determining enzyme in the synthesis of norepinephrine, in brain regions of GEPRs.	Norepinephrine	219-233	tyrosine hydroxylase	Rattus norvegicus	168-170
11108260-1	2000	Stimulation with the endogenous neurotransmitter, norepinephrine (NE; a mixed alpha- and beta-adrenergic agonist), concentration dependently increased the phosphorylation of both p44 and p42 isoforms of MAPK.	Norepinephrine	50-64	mitogen activated protein kinase 3	Rattus norvegicus	179-182
11108260-1	2000	Stimulation with the endogenous neurotransmitter, norepinephrine (NE; a mixed alpha- and beta-adrenergic agonist), concentration dependently increased the phosphorylation of both p44 and p42 isoforms of MAPK.	Norepinephrine	50-64	mitogen activated protein kinase 3	Rattus norvegicus	203-207
11145760-6	2000	beta1-Adrenergic receptor density in denervated rabbits receiving norepinephrine was lower than in those receiving saline but not in control rabbits receiving norepinephrine.	Norepinephrine	66-80	beta-1 adrenergic receptor	Oryctolagus cuniculus	0-25
10947955-7	2000	Noradrenaline-stimulated [(35)S]GTP[S] binding was markedly decreased in membranes from cells pretreated with EGF or PDGF.	Norepinephrine	0-13	epidermal growth factor like 1	Rattus norvegicus	110-113
10825155-5	2000	Ucp1(-/-) cells were as potent as wild-type in norepinephrine-induced cAMP accumulation and lipolysis and had a similar mitochondrial respiratory complement.	Norepinephrine	47-61	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	0-4
10860763-3	2000	Norepinephrine (NE) induces a rise in diacylglycerol levels which is sustained for 24 h and is associated with the translocation (at 5 min) and down-regulation (at 24 h) of PKC delta and PKC xi (but not PKC alpha).	Norepinephrine	0-14	protein kinase C delta	Homo sapiens	173-193
10860763-6	2000	WB-4101 (alpha(1A/c)- and alpha(1D)-receptor antagonist) and 5-methylurapidil (alpha(1A/c)-receptor antagonist) inhibit norepinephrine-dependent accumulation of inositol phosphate and diacylglycerol, down-regulation of PKC delta and PKC xi, and activation of ERK.	Norepinephrine	120-134	protein kinase C delta	Homo sapiens	219-228
10820200-2	2000	In cells stably expressing alpha(1A)-adrenergic receptors, norepinephrine activated all five reporters [AP1 (activator protein-1), SRE (serum response element), CRE (cyclic AMP response element), NFkappaB) (nuclear factor-kappaB), and NFAT (nuclear factor of activated T cells)], whereas nerve growth factor (NGF) and epidermal growth factor activated only AP1 and SRE.	Norepinephrine	59-73	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	104-107
10820200-2	2000	In cells stably expressing alpha(1A)-adrenergic receptors, norepinephrine activated all five reporters [AP1 (activator protein-1), SRE (serum response element), CRE (cyclic AMP response element), NFkappaB) (nuclear factor-kappaB), and NFAT (nuclear factor of activated T cells)], whereas nerve growth factor (NGF) and epidermal growth factor activated only AP1 and SRE.	Norepinephrine	59-73	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	109-128
10820200-2	2000	In cells stably expressing alpha(1A)-adrenergic receptors, norepinephrine activated all five reporters [AP1 (activator protein-1), SRE (serum response element), CRE (cyclic AMP response element), NFkappaB) (nuclear factor-kappaB), and NFAT (nuclear factor of activated T cells)], whereas nerve growth factor (NGF) and epidermal growth factor activated only AP1 and SRE.	Norepinephrine	59-73	nuclear factor of activated T-cells 5	Rattus norvegicus	235-239
10820200-2	2000	In cells stably expressing alpha(1A)-adrenergic receptors, norepinephrine activated all five reporters [AP1 (activator protein-1), SRE (serum response element), CRE (cyclic AMP response element), NFkappaB) (nuclear factor-kappaB), and NFAT (nuclear factor of activated T cells)], whereas nerve growth factor (NGF) and epidermal growth factor activated only AP1 and SRE.	Norepinephrine	59-73	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	357-360
10820200-5	2000	Mitogen-activated protein kinase kinase inhibition blocked AP1 activation by norepinephrine, but also potentiated CRE.	Norepinephrine	77-91	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	59-62
10820200-6	2000	p38 mitogen-activated protein kinase inhibition reduced most norepinephrine responses, but not NGF responses.	Norepinephrine	61-75	mitogen activated protein kinase 14	Rattus norvegicus	0-3
10749798-5	2000	Administration of norepinephrine to rats and isoproterenol to mice stimulated MT and UCP1 expression in BAT, implying a sympathetically mediated pathway for MT induction.	Norepinephrine	18-32	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	85-89
10688593-2	2000	Consequently, norepinephrine (NE) accumulates in the axoplasm, because it is no longer stored in synaptic vesicles, and intraneuronal Na(+) concentration increases, as the Na(+)/H(+) exchanger (NHE) is activated.	Norepinephrine	14-28	solute carrier family 9 member C1	Homo sapiens	172-192
10688593-2	2000	Consequently, norepinephrine (NE) accumulates in the axoplasm, because it is no longer stored in synaptic vesicles, and intraneuronal Na(+) concentration increases, as the Na(+)/H(+) exchanger (NHE) is activated.	Norepinephrine	14-28	solute carrier family 9 member C1	Homo sapiens	194-197
10888271-5	2000	We now demonstrate that, in addition to histamine, melatonin and the biogenic amines dopamine, serotonin and noradrenaline bind to P450 isozymes and to cytochrome C.	Norepinephrine	109-122	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	131-135
11268389-6	2000	The HPA-activating activity of IL-1 is associated with increases in the apparent release of brain noradrenaline (NA) and serotonin (5-HT), but not dopamine, as well as with increased brain tryptophan.	Norepinephrine	98-111	interleukin 1 complex	Mus musculus	31-35
10601817-1	2000	Endotoxin (lipopolysaccharide, LPS) and interleukin-1 (IL-1) are known to activate the hypothalamo-pituitary- adrenocortical (HPA) axis, as well as brain norepinephrine (NE) and indoleamine metabolism.	Norepinephrine	154-168	interleukin 1 complex	Mus musculus	40-53
10601817-1	2000	Endotoxin (lipopolysaccharide, LPS) and interleukin-1 (IL-1) are known to activate the hypothalamo-pituitary- adrenocortical (HPA) axis, as well as brain norepinephrine (NE) and indoleamine metabolism.	Norepinephrine	154-168	interleukin 1 complex	Mus musculus	55-59
11113335-1	2000	Mice deficient in monoamine oxidase A have previously been shown to demonstrate a chronic elevation of serotonin and norepinephrine in the brain.	Norepinephrine	117-131	monoamine oxidase A	Mus musculus	18-37
10578148-7	1999	The correlation with the potency of the series of alpha1-adrenoceptor antagonists against contractions to noradrenaline was significant only for the alpha1A-adrenoceptor ligand binding site (r=0.88, n=9, P&lt;0.01).	Norepinephrine	106-119	adrenoceptor alpha 1A	Rattus norvegicus	149-169
10564704-1	1999	Chromogranin A (CgA) is a member of a family of highly acidic proteins, chromogranins, which are co-stored in the adrenergic neurons and paraneurons and co-released with adrenaline and noradrenaline (NAd) in response to adequate stimulation.	Norepinephrine	185-198	chromogranin A	Rattus norvegicus	0-14
10564704-1	1999	Chromogranin A (CgA) is a member of a family of highly acidic proteins, chromogranins, which are co-stored in the adrenergic neurons and paraneurons and co-released with adrenaline and noradrenaline (NAd) in response to adequate stimulation.	Norepinephrine	185-198	chromogranin A	Rattus norvegicus	16-19
10564704-1	1999	Chromogranin A (CgA) is a member of a family of highly acidic proteins, chromogranins, which are co-stored in the adrenergic neurons and paraneurons and co-released with adrenaline and noradrenaline (NAd) in response to adequate stimulation.	Norepinephrine	200-203	chromogranin A	Rattus norvegicus	0-14
10564704-1	1999	Chromogranin A (CgA) is a member of a family of highly acidic proteins, chromogranins, which are co-stored in the adrenergic neurons and paraneurons and co-released with adrenaline and noradrenaline (NAd) in response to adequate stimulation.	Norepinephrine	200-203	chromogranin A	Rattus norvegicus	16-19
10564704-2	1999	The present study provides novel evidence that CgA-like immunoreactivity (IR) is stored in the exocrine cells in the granular convoluted tubule, and is secreted into saliva by stimulation with NAd and acetylcholine (ACh) in the isolated and perfused rat submandibular gland.	Norepinephrine	193-196	chromogranin A	Rattus norvegicus	47-50
10564704-3	1999	NAd at 1 microM produced maximum secretion of CgA-like IR (&lt;&lt; 0.9 mM) and a marked increase in salivary flow.	Norepinephrine	0-3	chromogranin A	Rattus norvegicus	46-49
10525059-1	1999	In myocardial ischemia, adrenergic terminals undergo ATP depletion, hypoxia, and intracellular pH reduction, causing the accumulation of axoplasmic norepinephrine (NE) and intracellular Na(+) [via the Na(+)-H(+) exchanger (NHE)].	Norepinephrine	148-162	solute carrier family 9 member C1	Homo sapiens	223-226
11281992-1	1999	A line of transgenic mice was isolated in which transgene integration had caused a deletion in the gene encoding monoamine oxidase A, an enzyme that degrades serotonin and norepinephrine.	Norepinephrine	172-186	monoamine oxidase A	Mus musculus	113-132
10406826-16	1999	Plasma noradrenaline was increased by combined, BNP, and higher dose ADM infusions (P&lt;0.05).	Norepinephrine	7-20	natriuretic peptide B	Homo sapiens	48-51
10401567-11	1999	Chlorethylclonidine (CEC) treatment nearly abolished (-)noradrenaline (NA) (10 microM)-induced inositol[1,4,5]trisphosphate (IP3) production, and BMY-7378 inhibited the response with a Ki value of 0.3 nM, which value was similar to that obtained in the cells expressing alpha 1D-AR.	Norepinephrine	53-69	adrenergic receptor, alpha 1d	Mus musculus	270-281
10395017-0	1999	Leptin inhibits norepinephrine and dopamine release from rat hypothalamic neuronal endings.	Norepinephrine	16-30	leptin	Rattus norvegicus	0-6
10395017-3	1999	We have found that leptin (0.01-10 nM) does not modify basal, while it inhibits depolarization-induced norepinephrine and dopamine release.	Norepinephrine	103-117	leptin	Rattus norvegicus	19-25
10212292-2	1999	We show with an in vivo approach that the norepinephrine cAMP-dependent rhythmic hormone production in rat pineal gland is accompanied by a temporally regulated switch in the ratio of a transcriptional activator, phosphorylated cAMP-responsive element-binding protein (pCREB), and a transcriptional inhibitor, inducible cAMP early repressor (ICER).	Norepinephrine	42-56	cAMP responsive element modulator	Rattus norvegicus	310-340
10212292-2	1999	We show with an in vivo approach that the norepinephrine cAMP-dependent rhythmic hormone production in rat pineal gland is accompanied by a temporally regulated switch in the ratio of a transcriptional activator, phosphorylated cAMP-responsive element-binding protein (pCREB), and a transcriptional inhibitor, inducible cAMP early repressor (ICER).	Norepinephrine	42-56	cAMP responsive element modulator	Rattus norvegicus	342-346
10070065-4	1999	FGF-2 RNA levels were increased after treatment with norepinephrine for 6 h or with the alpha-adrenergic agonist phenylephrine for 48 h. To assess an effect on transcription, neonatal rat cardiomyocytes were transfected with a hybrid rat FGF-2 promoter/luciferase gene (-1058FGFp.luc) and treated with norepinephrine or phenylephrine for 6 or 48 h, respectively.	Norepinephrine	53-67	fibroblast growth factor 2	Mus musculus	0-5
10070065-4	1999	FGF-2 RNA levels were increased after treatment with norepinephrine for 6 h or with the alpha-adrenergic agonist phenylephrine for 48 h. To assess an effect on transcription, neonatal rat cardiomyocytes were transfected with a hybrid rat FGF-2 promoter/luciferase gene (-1058FGFp.luc) and treated with norepinephrine or phenylephrine for 6 or 48 h, respectively.	Norepinephrine	302-316	fibroblast growth factor 2	Mus musculus	0-5
9920865-3	1999	Here we show that MIF is able to catalyze the conversion of 3,4-dihydroxyphenylaminechrome and norepinephrinechrome, toxic quinone products of the neurotransmitter catecholamines 3,4-dihydroxyphenylamine and norepinephrine, to indoledihydroxy derivatives that may serve as precursors to neuromelanin.	Norepinephrine	95-109	macrophage migration inhibitory factor	Homo sapiens	18-21
9928043-0	1998	PACAP increases cytosolic calcium in vasopressin neurons: synergism with noradrenaline.	Norepinephrine	73-86	adenylate cyclase activating polypeptide 1	Homo sapiens	0-5
9832123-6	1998	It is interesting that norepinephrine, which exhibited no effect on galanin mRNA expression, induced a down-regulation in the level of galanin or galanin-like product accumulated in the medium of cultured ODM-2 cells to levels even lower than those induced by beta2-adrenergic agonists.	Norepinephrine	23-37	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	260-265
9822156-2	1998	Introduction of the TH transgene directed by the dopamine beta-hydroxylase gene promoter into TH knockout mice restored noradrenaline and adrenaline synthesis, preventing perinatal lethality and cardiac dysfunction in the knockout mice.	Norepinephrine	120-133	tyrosine hydroxylase	Mus musculus	20-22
9822156-2	1998	Introduction of the TH transgene directed by the dopamine beta-hydroxylase gene promoter into TH knockout mice restored noradrenaline and adrenaline synthesis, preventing perinatal lethality and cardiac dysfunction in the knockout mice.	Norepinephrine	120-133	tyrosine hydroxylase	Mus musculus	94-96
9799438-3	1998	In a previous study in the pancreas of newborn guinea pig we reported the colocalization of nicotinamide adenine dinucleotide hydrogen phosphate-diaphorase (NADPH-d), a marker for nitric oxide synthase (NOS) with various neuropeptides as well as dopamine-beta-hydroxylase (DbetaH), the enzyme responsible for converting dopamine to noradrenaline.	Norepinephrine	332-345	nitric oxide synthase, inducible	Cavia porcellus	180-201
9740613-1	1998	Angiotensin II (Ang II), via its interaction with the angiotensin type 1 (AT1) receptor subtype, causes enhanced stimulation of norepinephrine (NE) neuromodulation.	Norepinephrine	128-142	angiotensin II receptor, type 1a	Rattus norvegicus	74-77
9717772-3	1998	In contrast, an injection of norepinephrine (NE) induced a comparable increase in UCP mRNA levels in control and MSG-obese mice.	Norepinephrine	29-43	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	82-85
9702745-10	1998	Individuals with COMT LL would be expected to have higher levels of transynaptic catecholamines due to a reduced COMT degradation of norepinephrine and dopamine.	Norepinephrine	133-147	catechol-O-methyltransferase	Homo sapiens	17-21
9702745-10	1998	Individuals with COMT LL would be expected to have higher levels of transynaptic catecholamines due to a reduced COMT degradation of norepinephrine and dopamine.	Norepinephrine	133-147	catechol-O-methyltransferase	Homo sapiens	113-117
9722189-9	1998	The plasma levels of epinephrine, norepinephrine, and glucagon rose significantly after TRH.	Norepinephrine	34-48	thyrotropin releasing hormone	Rattus norvegicus	88-91
9629250-4	1998	The hypothesized pathway is via norepinephrine (NE)-induced release of NO from NOergic neurons, which activates LHRH release.	Norepinephrine	32-46	gonadotropin releasing hormone 1	Homo sapiens	112-116
9605575-19	1998	The inhibitory effect of halpha-CGRP on noradrenaline-induced contractions in both the prostatic and epididymal vas deferens was antagonized by halpha-CGRP8-37 (pA2 5.8 and 5.8, slope 1.0+/-0.2 and 1.0+/-0.3, respectively).	Norepinephrine	40-53	calcitonin-related polypeptide alpha	Rattus norvegicus	32-36
9573502-10	1998	Compared to placebo, hBNP decreased plasma norepinephrine and aldosterone.	Norepinephrine	43-57	natriuretic peptide B	Homo sapiens	21-25
9573502-14	1998	3) Plasma norepinephrine and aldosterone levels decreased during hBNP infusion.	Norepinephrine	10-24	natriuretic peptide B	Homo sapiens	65-69
9490860-4	1998	Expression of the C-terminus domain of beta-adrenergic receptor kinase 1 (beta ARK1), which contains the consensus motif (QXXER) for binding G beta gamma, reduced the fast (pertussis toxin (PTX)-sensitive) and voltage-dependent inhibition of ICa by noradrenaline and somatostatin, but not the slow (PTX-insensitive) and voltage-independent inhibition induced by angiotensin II.	Norepinephrine	249-262	G protein-coupled receptor kinase 2	Rattus norvegicus	39-83
9489621-14	1998	7 In conclusion, the alpha1A-adrenoceptor mediated contraction to noradrenaline of the rat prostatic vas deferens appears to consist of an initial phasic component due to the release of intracellular Ca2+ from ryanodine-sensitive stores.	Norepinephrine	66-79	adrenoceptor alpha 1A	Rattus norvegicus	21-41
7773533-0	1995	Mediation of noradrenaline-induced contractions of rat aorta by the alpha 1B-adrenoceptor subtype.	Norepinephrine	13-26	adrenoceptor alpha 1B	Rattus norvegicus	68-89
7966778-4	1995	Norepinephrine-induced contractions were competitively and effectively inhibited with WB 4101, a competitive, high-affinity antagonist for alpha 1A-AR and alpha 1C-AR subtypes.	Norepinephrine	0-14	adrenoceptor alpha 1A	Homo sapiens	139-166
8532586-3	1995	In comparison with adjacent sections stained with antisera to catecholamine synthesizing enzymes, PACAP-positive cells were immunoreactive to tyrosine hydroxylase and dopamine beta-hydroxylase, but not to phenylethanolamine-N-methyltransferase, suggesting that they were coincident with noradrenaline secreting cells.	Norepinephrine	287-300	adenylate cyclase activating polypeptide 1	Rattus norvegicus	98-103
7713121-5	1994	Aldosterone, cAMP, norepinephrine and extracellular glucose concentrations can contribute to AT1 regulation.	Norepinephrine	19-33	angiotensin II receptor type 1	Homo sapiens	93-96
7844319-1	1994	3-Methoxy-4-hydroxyphenylglycol (MHPG) is formed by the sequential actions of monoamine oxidase (MAO) and catechol-O-methyltransferase on norepinephrine within extraneuronal tissues or by extraneuronal O-methylation of 3,4-dihydroxyphenylglycol (DHPG) produced intraneuronally from norepinephrine.	Norepinephrine	138-152	monoamine oxidase A	Rattus norvegicus	78-95
7844319-1	1994	3-Methoxy-4-hydroxyphenylglycol (MHPG) is formed by the sequential actions of monoamine oxidase (MAO) and catechol-O-methyltransferase on norepinephrine within extraneuronal tissues or by extraneuronal O-methylation of 3,4-dihydroxyphenylglycol (DHPG) produced intraneuronally from norepinephrine.	Norepinephrine	138-152	monoamine oxidase A	Rattus norvegicus	97-100
7844319-1	1994	3-Methoxy-4-hydroxyphenylglycol (MHPG) is formed by the sequential actions of monoamine oxidase (MAO) and catechol-O-methyltransferase on norepinephrine within extraneuronal tissues or by extraneuronal O-methylation of 3,4-dihydroxyphenylglycol (DHPG) produced intraneuronally from norepinephrine.	Norepinephrine	282-296	monoamine oxidase A	Rattus norvegicus	78-95
7844319-1	1994	3-Methoxy-4-hydroxyphenylglycol (MHPG) is formed by the sequential actions of monoamine oxidase (MAO) and catechol-O-methyltransferase on norepinephrine within extraneuronal tissues or by extraneuronal O-methylation of 3,4-dihydroxyphenylglycol (DHPG) produced intraneuronally from norepinephrine.	Norepinephrine	282-296	monoamine oxidase A	Rattus norvegicus	97-100
7803985-5	1994	Since MAO-A is an isoform of MAO that preferentially uses norepinephrine and serotonin as substrates and MAO-B acts on phenylethylamine and benzylamine as substrates, our findings suggest that the restoration of sexual behavior after the treatment with estradiol benzoate followed by progesterone may be associated with the differential effect exerted by the hormones on MAO subtypes, rather than to the simple decrease in hypothalamic monoamine concentrations as reported in the literature.	Norepinephrine	58-72	monoamine oxidase A	Rattus norvegicus	6-11
7803985-5	1994	Since MAO-A is an isoform of MAO that preferentially uses norepinephrine and serotonin as substrates and MAO-B acts on phenylethylamine and benzylamine as substrates, our findings suggest that the restoration of sexual behavior after the treatment with estradiol benzoate followed by progesterone may be associated with the differential effect exerted by the hormones on MAO subtypes, rather than to the simple decrease in hypothalamic monoamine concentrations as reported in the literature.	Norepinephrine	58-72	monoamine oxidase A	Rattus norvegicus	6-9
7803985-5	1994	Since MAO-A is an isoform of MAO that preferentially uses norepinephrine and serotonin as substrates and MAO-B acts on phenylethylamine and benzylamine as substrates, our findings suggest that the restoration of sexual behavior after the treatment with estradiol benzoate followed by progesterone may be associated with the differential effect exerted by the hormones on MAO subtypes, rather than to the simple decrease in hypothalamic monoamine concentrations as reported in the literature.	Norepinephrine	58-72	monoamine oxidase A	Rattus norvegicus	29-32
7875540-2	1994	Isolated aortic segments from transgenic rats for the mouse renin gene Ren-2 were more sensitive than those from control Sprague-Dawley ones to the vasoconstrictions induced by angiotensin II and to the potentiation of norepinephrine contractions by this peptide.	Norepinephrine	219-233	renin	Rattus norvegicus	60-65
7875540-2	1994	Isolated aortic segments from transgenic rats for the mouse renin gene Ren-2 were more sensitive than those from control Sprague-Dawley ones to the vasoconstrictions induced by angiotensin II and to the potentiation of norepinephrine contractions by this peptide.	Norepinephrine	219-233	renin 2 tandem duplication of Ren1	Mus musculus	71-76
7875540-6	1994	These results suggest that in the aorta of transgenic rats there is a higher functional tissue renin-angiotensin system that potentiates the vascular reactivity to norepinephrine.	Norepinephrine	164-178	renin	Rattus norvegicus	95-100
7530592-0	1994	Insulin potentiates norepinephrine-induced vascular tone by activation of protein kinase C and tyrosine kinase.	Norepinephrine	20-34	insulin	Oryctolagus cuniculus	0-7
7530592-2	1994	In addition, insulin has recently been shown to potentiate norepinephrine (NE) induced vascular tone.	Norepinephrine	59-73	insulin	Oryctolagus cuniculus	13-20
8204666-10	1994	Furthermore, a similar transcriptional regulation of the PNMT gene in keratinocytes offers a possible explanation for the accumulation of norepinephrine in these patients.	Norepinephrine	138-152	phenylethanolamine N-methyltransferase	Homo sapiens	57-61
8045271-10	1994	The 5-HT2A/2C receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane increased the release of [3H]noradrenaline, but this effect was not blocked with the 5-HT3 receptor antagonist ondansetron.	Norepinephrine	106-119	5-hydroxytryptamine receptor 3A	Rattus norvegicus	162-176
7957717-9	1994	The findings of this study suggest that the pattern of MAO-A parallels both in neuroanatomical distribution and in density that of norepinephrine and serotonin innervation.	Norepinephrine	131-145	monoamine oxidase A	Rattus norvegicus	55-60
7906468-1	1993	Norepinephrine is a major regulator of the release of growth hormone.	Norepinephrine	0-14	gonadotropin releasing hormone receptor	Rattus norvegicus	54-68
8246156-0	1993	Types A and B monoamine oxidase contribute to the metabolism of norepinephrine in perfused lungs of rats.	Norepinephrine	64-78	monoamine oxidase A	Rattus norvegicus	14-31
8246156-1	1993	The aim of the study was to determine the activity of monoamine oxidase (MAO) and the contributions of the A and B forms of MAO to the metabolism of norepinephrine (NE) in isolated perfused lungs of the rat.	Norepinephrine	149-163	monoamine oxidase A	Rattus norvegicus	124-127
8223378-6	1993	However, affected neurons showed a marked increase in dopamine-beta-hydroxylase (D beta H), another enzyme associated with noradrenaline synthesis.	Norepinephrine	123-136	dopamine beta-hydroxylase	Equus caballus	54-79
8104641-6	1993	Following alpha-blockade with 10 microM phenoxybenzamine, both noradrenaline adrenaline produced concentration-dependent relaxations in both blood vessels, their effects being mediated predominantly through beta 2-adrenoceptors; a lesser beta 1-adrenoceptor component to relaxation was also found in internal mammary artery and a minor beta 1-adrenoceptor component was present in saphenous vein.	Norepinephrine	63-76	adrenoceptor beta 1	Homo sapiens	238-257
8104641-6	1993	Following alpha-blockade with 10 microM phenoxybenzamine, both noradrenaline adrenaline produced concentration-dependent relaxations in both blood vessels, their effects being mediated predominantly through beta 2-adrenoceptors; a lesser beta 1-adrenoceptor component to relaxation was also found in internal mammary artery and a minor beta 1-adrenoceptor component was present in saphenous vein.	Norepinephrine	63-76	adrenoceptor beta 1	Homo sapiens	336-355
8104643-6	1993	The selective beta 2-adrenoceptor blocking drug, ICI 118551, also produced concentration-dependent antagonism of noradrenaline, but only when used in concentrations greater than 300 nM.	Norepinephrine	113-126	beta-2 adrenergic receptor	Cavia porcellus	14-33
8393767-10	1993	Norepinephrine (NE) plays a major role in the regulation of S14 gene, and 24 h after its addition, NE elicited a 20-fold decrease in mRNA S14 concentrations.	Norepinephrine	0-14	thyroid hormone responsive	Homo sapiens	60-63
8393767-10	1993	Norepinephrine (NE) plays a major role in the regulation of S14 gene, and 24 h after its addition, NE elicited a 20-fold decrease in mRNA S14 concentrations.	Norepinephrine	0-14	thyroid hormone responsive	Homo sapiens	138-141
8104891-3	1993	O-2A progenitor cells (A2B5+/GFAP-) and mature oligodendroglia (GC+/MBP+) responded to norepinephrine, glutamate, ATP, and histamine with increased intracellular Ca2+ levels.	Norepinephrine	87-101	myelin basic protein	Homo sapiens	68-71
7951503-1	1993	Biochemical investigations have shown the presence of the enzyme phenylethanolamine N-methyltransferase (PNMT), which converts norepinephrine (NE) to epinephrine (E) in human pregnant tissues, e.g. myometrium and fetal membranes.	Norepinephrine	127-141	phenylethanolamine N-methyltransferase	Homo sapiens	65-103
7951503-1	1993	Biochemical investigations have shown the presence of the enzyme phenylethanolamine N-methyltransferase (PNMT), which converts norepinephrine (NE) to epinephrine (E) in human pregnant tissues, e.g. myometrium and fetal membranes.	Norepinephrine	127-141	phenylethanolamine N-methyltransferase	Homo sapiens	105-109
8510765-4	1993	Uptake of noradrenaline was manifested after 30 minutes as a 6-fold increase in the cell content of the amine following inhibition of catechol-O-methyl transferase, either alone or in conjunction with inhibition of monoamine oxidase.	Norepinephrine	10-23	catechol-O-methyltransferase	Homo sapiens	134-163
8449230-3	1993	In contrast, endothelium-1 and endothelin-3 at similar concentrations induced endothelium-dependent relaxation in norepinephrine-stimulated aorta.	Norepinephrine	114-128	endothelin 3	Rattus norvegicus	31-43
1473014-1	1992	Both interleukin-1 (IL-1) and endotoxin (lipopolysaccharide, LPS) are potent activators of the hypothalamo-pituitary-adrenal (HPA) axis, and they also increase cerebral norepinephrine metabolism and tryptophan.	Norepinephrine	169-183	interleukin 1 complex	Mus musculus	20-24
1330175-0	1992	Inhibition of noradrenaline release in the rat vena cava via prostanoid receptors of the EP3-subtype.	Norepinephrine	14-27	prostaglandin E receptor 3	Rattus norvegicus	89-92
1279289-4	1992	beta 1-Adrenoceptor-mediated effects were isoprenaline (ISO) infusion-induced increase in systolic blood pressure (SBP) and bicycle exercise-induced increase in heart rate (HR); beta 2-adrenoceptor-mediated effects were ISO infusion-induced increase in plasma norepinephrine (NE) and decrease in diastolic blood pressure (DBP); ISO infusion-induced increase in HR was assessed as mixed beta 1- and beta 2-adrenoceptor-mediated effect.	Norepinephrine	260-274	adrenoceptor beta 1	Homo sapiens	0-19
1320047-2	1992	The lipolytic sensitivity of the nonselective beta-agonists epinephrine and isoprenaline as well as the selective agonists norepinephrine (beta 1) and terbutaline (beta 2) was significantly increased 5-10 times in omental fat cells.	Norepinephrine	123-137	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	164-170
1599423-4	1992	High levels of thermogenin could be induced by noradrenaline treatment in cells grown for more than 5 days in culture, and in such cell cultures continuously stimulated with noradrenaline, the thermogenin level continued to increase for at least a further 5 days.	Norepinephrine	174-187	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	193-204
1599423-6	1992	In cell cultures continuously stimulated with noradrenaline for 5 days, the induced thermogenin was degraded much more slowly after noradrenaline removal, with a half-life of 70 h. This half-life was unchanged by cycloheximide treatment, and the degradation after cycloheximide was in parallel with the degradation of protein in general, and was therefore non-specific.	Norepinephrine	46-59	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	84-95
1599423-6	1992	In cell cultures continuously stimulated with noradrenaline for 5 days, the induced thermogenin was degraded much more slowly after noradrenaline removal, with a half-life of 70 h. This half-life was unchanged by cycloheximide treatment, and the degradation after cycloheximide was in parallel with the degradation of protein in general, and was therefore non-specific.	Norepinephrine	132-145	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	84-95
1635665-1	1992	Neuropeptide Y (NPY) is found to be costored with norepinephrine (NE) in vesicles of the nerve terminals.	Norepinephrine	50-64	neuropeptide Y	Bos taurus	0-14
1635665-1	1992	Neuropeptide Y (NPY) is found to be costored with norepinephrine (NE) in vesicles of the nerve terminals.	Norepinephrine	50-64	neuropeptide Y	Bos taurus	16-19
21554570-1	1992	While the pharmacology of noradrenaline effects on growth hormone (GH) secretion has been extensively studied, the precise localization of noradrenergic neurons involved remains unclear.	Norepinephrine	26-39	gonadotropin releasing hormone receptor	Rattus norvegicus	51-65
1363262-5	1992	On the other hand, noradrenaline induces its positive inotropic effect on atrial and ventricular preparations solely via beta 1-adrenoceptor stimulation.	Norepinephrine	19-32	adrenoceptor beta 1	Homo sapiens	121-140
1665747-11	1991	(-)-Adrenaline and (-)-noradrenaline showed dissimilar order of affinities for the three alpha2-adrenoceptors.	Norepinephrine	19-36	adrenoceptor alpha 2A	Rattus norvegicus	89-109
1777845-7	1991	Moreover, CP significantly reduced the increase of norepinephrine washout in the effluent perfusate after electrolysis suggesting a protection against free radical-induced injury to sympathetic nerve endings.	Norepinephrine	51-65	ceruloplasmin	Rattus norvegicus	10-12
1665896-3	1991	Maximum relaxations to CGRP, which represented 40-50% reversal of the norepinephrine-induced contractions, occurred with 100 nM CGRP.	Norepinephrine	70-84	calcitonin-related polypeptide alpha	Rattus norvegicus	23-27
1665896-3	1991	Maximum relaxations to CGRP, which represented 40-50% reversal of the norepinephrine-induced contractions, occurred with 100 nM CGRP.	Norepinephrine	70-84	calcitonin-related polypeptide alpha	Rattus norvegicus	128-132
1685997-2	1991	It was found that noradrenaline and the alpha 1-adrenoceptor agonist phenylephrine, but not the alpha 2-adrenoceptor agonist UK 14,304, inhibited insulin secretion.	Norepinephrine	18-31	insulin	Sus scrofa	146-153
1851566-4	1991	The IgG against the beta 1-adrenoceptor inhibited the action of norepinephrine on the contractility of atria.	Norepinephrine	64-78	adrenoceptor beta 1	Homo sapiens	20-39
1881457-2	1991	N2-Acetylphenelzine is a relatively potent inhibitor of monoamine oxidase-A and -B and causes increases in whole-brain levels of noradrenaline and 5-hydroxytryptamine, and decreases in homovanillic acid, 5-hydroxyindole-3-acetic acid, and 3,4-dihydroxyphenylacetic acetic after acute i.p.	Norepinephrine	129-142	monoamine oxidase A	Rattus norvegicus	56-82
1907737-9	1991	The TRH-treated duodenal preparation responded normally to noradrenaline but remained unresponsive to further administrations of TRH until washed extensively.	Norepinephrine	59-72	thyrotropin releasing hormone	Rattus norvegicus	4-7
1908674-2	1991	A single injection of norepinephrine (2.5 micrograms/kg to 2.5 mg/kg) led to transient increases in the levels of both c-fos and c-myc mRNA.	Norepinephrine	22-36	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	129-134
1671583-1	1991	The enzyme tyrosine hydroxylase catalyzes the first step in the biosynthesis of dopamine, norepinephrine, and epinephrine.	Norepinephrine	90-104	tyrosine hydroxylase	Rattus norvegicus	11-31
1677416-8	1991	Noradrenaline (NA) concentrations in GPe and GPi are 56 and 43% of the control mean, respectively.	Norepinephrine	0-13	glucose-6-phosphate isomerase	Homo sapiens	45-48
1709230-4	1991	Furthermore, the selective beta 2-adrenoceptor antagonist ICI 118,551 (10(-7) mol/L), but not the selective beta 1-adrenoceptor antagonist ICI 89,406 (10(-7) mol/L), reduced electrically evoked overflow of (3H)noradrenaline in tissue preincubated with adrenaline but not in tissue preincubated with noradrenaline.	Norepinephrine	210-223	beta-2 adrenergic receptor	Cavia porcellus	27-46
1849535-0	1991	The antihypertensive effect of calcitonin gene-related peptide in rats with norepinephrine- and angiotensin II-induced hypertension.	Norepinephrine	76-90	calcitonin-related polypeptide alpha	Rattus norvegicus	31-62
1849535-2	1991	CGRP (0.05 micrograms/kg per min) administered simultaneously with norepinephrine (1.8 mg/kg per day) significantly reduced the systolic blood pressure of conscious rats compared with norepinephrine infusion alone.	Norepinephrine	184-198	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
1849535-6	1991	Thus, a subdepressor dose of CGRP can modulate the vasopressor effects of norepinephrine and angiotensin II.	Norepinephrine	74-88	calcitonin-related polypeptide alpha	Rattus norvegicus	29-33
1671089-3	1991	In sympathetic neurons, depolarization also increases the rate of synthesis of the transmitter norepinephrine (NE), via an activation of the enzyme tyrosine hydroxylase (TH), and this effect also seems to involve Ca2+ entry.	Norepinephrine	95-109	tyrosine hydroxylase	Rattus norvegicus	148-168
2243334-6	1990	In addition to the vasodilator action, CGRP also inhibited nerve stimulation-induced and norepinephrine-induced vasoconstriction at extremely low concentrations.	Norepinephrine	89-103	calcitonin-related polypeptide alpha	Rattus norvegicus	39-43
2243334-7	1990	The inhibitory action of CGRP appeared to be mediated by postsynaptic mechanisms inasmuch as evoked norepinephrine release was not affected by CGRP when the vasoconstriction produced by norepinephrine or periarterial nerve stimulation was attenuated greatly by CGRP.	Norepinephrine	100-114	calcitonin-related polypeptide alpha	Rattus norvegicus	25-29
2282079-2	1990	Loss of insulin receptor activity is linear with cellular ageing and norepinephrine and epinephrine levels increase with age together with levels of glycosylated hemoglobin in control animals and this correlation is altered in hyperglycemia and hyperinsulinemia.	Norepinephrine	69-83	insulin receptor	Rattus norvegicus	8-24
1979424-1	1990	The present study aimed at relating the presynaptic alpha 2-adrenoceptors, known to modulate noradrenaline and serotonin release, with the recently described alpha 2A- and alpha 2B-adrenoceptor subtypes.	Norepinephrine	93-106	adrenoceptor alpha 2A	Rattus norvegicus	158-193
1979424-7	1990	These results indicate that presynaptic alpha 2 auto- or heteroreceptors do not belong to the alpha 2B subtype and suggest that the modulation of noradrenaline and serotonin release may be mediated by the alpha 2A-adrenoceptor subtype.	Norepinephrine	146-159	adrenoceptor alpha 2A	Rattus norvegicus	205-226
2168019-7	1990	We show that noradrenaline, through beta-adrenergic stimulation and increase of cyclic AMP, stimulates a large efflux of Mg2+ from cardiac cells.	Norepinephrine	13-26	mucin 7, secreted	Homo sapiens	121-124
2386305-3	1990	Although uptake1 is the most important process for the removal of norepinephrine from the synaptic cleft, the net accumulation of norepinephrine within the neuron also depends on other factors including its vesicular uptake and storage within the granules, its metabolism by monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT), and the efflux of its more lipophilic metabolites.	Norepinephrine	130-144	monoamine oxidase A	Rattus norvegicus	275-292
2386305-3	1990	Although uptake1 is the most important process for the removal of norepinephrine from the synaptic cleft, the net accumulation of norepinephrine within the neuron also depends on other factors including its vesicular uptake and storage within the granules, its metabolism by monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT), and the efflux of its more lipophilic metabolites.	Norepinephrine	130-144	monoamine oxidase A	Rattus norvegicus	294-297
2118962-4	1990	The present studies show that nerve growth factor treatment increases the release of dopamine and norepinephrine from the cells within a few minutes and does so independently of its effect on their metabolism.	Norepinephrine	98-112	nerve growth factor	Rattus norvegicus	30-49
1971535-2	1990	(-)Norepinephrine produced stimulation predominantly through beta 1-receptors and (-)epinephrine through both beta 1- and beta 2-receptors.	Norepinephrine	3-17	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	122-128
1971540-5	1990	Plasma norepinephrine decreased with administration of beta 2-blockade.	Norepinephrine	7-21	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	55-61
1971540-8	1990	Norepinephrine may be less consistently related to the blood pressure rise during flight phobia stress as shown by the decrease in plasma norepinephrine with administration of beta 2-blockade.	Norepinephrine	0-14	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	176-182
1971540-8	1990	Norepinephrine may be less consistently related to the blood pressure rise during flight phobia stress as shown by the decrease in plasma norepinephrine with administration of beta 2-blockade.	Norepinephrine	138-152	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	176-182
1970788-1	1990	Bovine adrenal tyrosine hydroxylase (TH) is isolated in a partially inhibited state with the feed-back inhibitors adrenaline and noradrenaline tightly coordinated to high-spin (S = 5/2) Fe(III) at the active site.	Norepinephrine	129-142	tyrosine hydroxylase	Bos taurus	15-35
1969352-0	1990	Evidence for a relationship between B-50 (GAP-43) and [3H]noradrenaline release in rat brain synaptosomes.	Norepinephrine	58-71	growth associated protein 43	Rattus norvegicus	42-48
1968697-4	1990	Noradrenaline, on the other hand, caused a positive inotropic effect nearly exclusively via atrial and ventricular beta-1 adrenoceptor stimulation.	Norepinephrine	0-13	adrenoceptor beta 1	Homo sapiens	115-134
1980361-1	1990	Ipsapirone, a new anxiolytic drug with a high affinity to 5-HT1A receptors, given in a dose of 10 mg/kg ip markedly accelerated noradrenaline disappearance after inhibition of tyrosine hydroxylase with alpha-methyl-p-tyrosine (250 mg/kg ip) in the cortex, hippocampus and hypothalamus of male Wistar rats.	Norepinephrine	128-141	5-hydroxytryptamine receptor 1A	Rattus norvegicus	58-64
1980361-4	1990	8-OH-DPAT, a selective agonist of 5-HT1A receptors, used in a dose of 5 mg/kg sc was less effective, having accelerated noradrenaline disappearance in the cortex and hypothalamus, and having increased only the level of homovanillic acid in the striatum.	Norepinephrine	120-133	5-hydroxytryptamine receptor 1A	Rattus norvegicus	34-40
2227123-6	1990	Moreover, although intravenous injection of CGRP (5.67 nmol/kg) elicited a significant increase in plasma epinephrine and norepinephrine concentrations, concomitant administration of epinephrine and norepinephrine, inducing a more prominent rise in plasma catecholamines than those induced by CGRP, affected neither plasma glucose nor insulin levels.	Norepinephrine	199-213	calcitonin-related polypeptide alpha	Rattus norvegicus	44-48
2227123-6	1990	Moreover, although intravenous injection of CGRP (5.67 nmol/kg) elicited a significant increase in plasma epinephrine and norepinephrine concentrations, concomitant administration of epinephrine and norepinephrine, inducing a more prominent rise in plasma catecholamines than those induced by CGRP, affected neither plasma glucose nor insulin levels.	Norepinephrine	199-213	calcitonin-related polypeptide alpha	Rattus norvegicus	293-297
1688789-0	1990	Interaction between norepinephrine and serotonin in the neuroendocrine control of growth hormone release in the rat.	Norepinephrine	20-34	gonadotropin releasing hormone receptor	Rattus norvegicus	82-96
2302560-7	1990	DMRF stimulation induced widespread increases in rCBF associated with a 50-fold increase in plasma epinephrine and a 20-fold increase in norepinephrine without changes in the electroencephalogram.	Norepinephrine	137-151	CCAAT/enhancer binding protein zeta	Rattus norvegicus	49-53
2196129-1	1990	Previous investigations have shown that depletion of brain norepinephrine (NE) induced by chemical sympathectomy resulted in significant changes in the central renin-angiotensin system.	Norepinephrine	59-73	renin	Rattus norvegicus	160-165
2311372-1	1990	In young chickens plasma concentrations of growth hormone (GH) are depressed by prostaglandins (PG) E1 and E2, epinephrine, norepinephrine, alpha 2 and beta agonists or thyroid hormones.	Norepinephrine	124-138	growth hormone	Gallus gallus	43-57
2311372-1	1990	In young chickens plasma concentrations of growth hormone (GH) are depressed by prostaglandins (PG) E1 and E2, epinephrine, norepinephrine, alpha 2 and beta agonists or thyroid hormones.	Norepinephrine	124-138	growth hormone	Gallus gallus	59-61
2358372-8	1990	In the adult medulla bFGF colocalizes with noradrenaline suggesting its presence in a chromaffin cell subpopulation.	Norepinephrine	43-56	fibroblast growth factor 2	Rattus norvegicus	21-25
11527117-5	1990	On the other hand, norepinephrine induces its positive inotropic effect on atrial and ventricular preparations solely via beta1-adrenoceptor stimulation.	Norepinephrine	19-33	adrenoceptor beta 1	Homo sapiens	122-140
2295700-0	1990	Cerebroventricular calcitonin gene-related peptide inhibits rat duodenal bicarbonate secretion by release of norepinephrine and vasopressin.	Norepinephrine	109-123	calcitonin-related polypeptide alpha	Rattus norvegicus	19-50
33806634-1	2021	The noradrenaline and dopamine reuptake inhibitor bupropion is metabolized by CYP2B6 and recommended by the FDA as the only sensitive substrate for clinical CYP2B6 drug-drug interaction (DDI) studies.	Norepinephrine	4-17	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	78-84
33806634-1	2021	The noradrenaline and dopamine reuptake inhibitor bupropion is metabolized by CYP2B6 and recommended by the FDA as the only sensitive substrate for clinical CYP2B6 drug-drug interaction (DDI) studies.	Norepinephrine	4-17	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	157-163
34889236-4	2021	There were the significant differences in the levels of dopamine and noradrenalin between the 2 groups (dopamine: t = 4.30, P < .01; noradrenalin: t = 2.24, P < .05).Our study suggested that the Val158Met polymorphisms of the COMT gene and serum concentrations of catecholaminergic neurotransmitters were associated with ADHD children and adolescents.	Norepinephrine	69-81	catechol-O-methyltransferase	Homo sapiens	226-230
34889236-4	2021	There were the significant differences in the levels of dopamine and noradrenalin between the 2 groups (dopamine: t = 4.30, P < .01; noradrenalin: t = 2.24, P < .05).Our study suggested that the Val158Met polymorphisms of the COMT gene and serum concentrations of catecholaminergic neurotransmitters were associated with ADHD children and adolescents.	Norepinephrine	133-145	catechol-O-methyltransferase	Homo sapiens	226-230
34789005-9	2021	In vitro, norepinephrine promoted translocation of SGLT2 to the cell membrane.	Norepinephrine	10-24	solute carrier family 5 member 2	Rattus norvegicus	51-56
34789005-11	2021	Potentiated trafficking of SGLT2 to cell surface in renal proximal tubules mediated by norepinephrine may contribute to this functional activation of SGLT2 in HF.	Norepinephrine	87-101	solute carrier family 5 member 2	Rattus norvegicus	27-32
34789005-11	2021	Potentiated trafficking of SGLT2 to cell surface in renal proximal tubules mediated by norepinephrine may contribute to this functional activation of SGLT2 in HF.	Norepinephrine	87-101	solute carrier family 5 member 2	Rattus norvegicus	150-155
34329999-1	2021	Vesicular monoamine transporter 2 (VMAT2) is essential for synaptic transmission of all biogenic amines in the brain including serotonin, norepinephrine, histamine, and dopamine (DA).	Norepinephrine	138-152	solute carrier family 18 member A2	Homo sapiens	0-33
34329999-1	2021	Vesicular monoamine transporter 2 (VMAT2) is essential for synaptic transmission of all biogenic amines in the brain including serotonin, norepinephrine, histamine, and dopamine (DA).	Norepinephrine	138-152	solute carrier family 18 member A2	Homo sapiens	35-40
34668531-0	2021	AMPK activation by SC4 inhibits noradrenaline-induced lipolysis and insulin-stimulated lipogenesis in white adipose tissue.	Norepinephrine	32-45	secretory carrier membrane protein 4	Mus musculus	19-22
34668531-3	2021	Incubation of rat adipocytes with SC4 + AICA riboside inhibited noradrenaline-induced lipolysis and decreased hormone-sensitive lipase (HSL) Ser563 phosphorylation, without affecting HSL Ser565 phosphorylation.	Norepinephrine	64-77	secretory carrier membrane protein 4	Mus musculus	34-37
34679865-0	2021	Salivary Chromogranin A (CgA) Response to the Noradrenaline Transporter Blocker Atomoxetine in Dogs.	Norepinephrine	46-59	chromogranin-A	Canis lupus familiaris	25-28
34679865-2	2021	Our hypothesis was that salivary CgA would increase when central noradrenaline was pharmacologically induced.	Norepinephrine	65-78	chromogranin-A	Canis lupus familiaris	33-36
34158361-1	2021	Norepinephrine (NE) controls many vital body functions by activating adrenergic receptors (AR).	Norepinephrine	0-14	ferredoxin reductase	Mus musculus	69-89
34158361-1	2021	Norepinephrine (NE) controls many vital body functions by activating adrenergic receptors (AR).	Norepinephrine	0-14	ferredoxin reductase	Mus musculus	91-93
34174371-4	2021	In order to investigate the effect of norepinephrine (NE) on the IGL neurons we have performed ex vivo recordings using the extracellular multi-electrode array technique as well as the intracellular whole-cell patch clamp.	Norepinephrine	38-52	immunoglobulin lambda chain complex	Rattus norvegicus	65-68
34174371-7	2021	To the best of our knowledge, these are the first studies to confirm the effects of norepinephrine on the activity of the IGL network.	Norepinephrine	84-98	immunoglobulin lambda chain complex	Rattus norvegicus	122-125
34351905-3	2021	IL-25 induced beige fat formation in white adipose tissue (WAT) by releasing IL-4 and IL-13 and promoting alternative activation of macrophages that regulate innervation and up-regulate tyrosine hydroxylase (TH) up-regulation to produce more catecholamine including norepinephrine (NE).	Norepinephrine	266-280	interleukin 25	Mus musculus	0-5
34230886-12	2021	Firstly, through the downregulation of angiotensin-converting enzyme 2 receptors, resulting in the imbalance of dopamine and norepinephrine; and secondly, the virus could cause cellular vacuolation, demyelination and gliosis, leading to encephalitis and associated movement disorders.	Norepinephrine	125-139	angiotensin converting enzyme 2	Homo sapiens	39-70
35486829-0	2022	Retraction of: Norepinephrine Protects Cerebral Autoregulation and Reduces Hippocampal Necrosis after Traumatic Brain Injury via Blockade of ERK MAPK and IL-6 in Juvenile Pigs (DOI: 10.1089/neu.2015.4290).	Norepinephrine	15-29	interleukin 6	Sus scrofa	154-158
35533359-1	2022	Catechol O-methyltransferase (COMT) plays a vital role in deactivating neurotransmitters like dopamine, norepinephrine, etc., by methylating those compounds.	Norepinephrine	104-118	catechol-O-methyltransferase	Homo sapiens	0-28
35533359-1	2022	Catechol O-methyltransferase (COMT) plays a vital role in deactivating neurotransmitters like dopamine, norepinephrine, etc., by methylating those compounds.	Norepinephrine	104-118	catechol-O-methyltransferase	Homo sapiens	30-34
35442745-5	2022	We show that norepinephrine induces erratic firing of Purkinje cells by disrupting their spontaneous intrinsic pacemaking via a casein kinase 2 (CK2)-dependent signaling pathway, which likely reduces the activity of calcium-dependent potassium channels.	Norepinephrine	13-27	casein kinase 2, alpha prime polypeptide	Mus musculus	128-143
35442745-5	2022	We show that norepinephrine induces erratic firing of Purkinje cells by disrupting their spontaneous intrinsic pacemaking via a casein kinase 2 (CK2)-dependent signaling pathway, which likely reduces the activity of calcium-dependent potassium channels.	Norepinephrine	13-27	casein kinase 2, alpha prime polypeptide	Mus musculus	145-148
35397615-10	2022	In the CSF neurogranin positively associated with noradrenaline and adrenaline but not with dopamine.	Norepinephrine	50-63	neurogranin	Homo sapiens	11-22
35332321-2	2022	In the present study, we show that DOPEGAL, a monoamine oxidase A (MAO-A) metabolite of norepinephrine (NE), reacts directly with the primary amine on the Lys353 residue of tau to stimulate its aggregation and facilitate its propagation.	Norepinephrine	88-102	monoamine oxidase A	Mus musculus	46-65
35332321-2	2022	In the present study, we show that DOPEGAL, a monoamine oxidase A (MAO-A) metabolite of norepinephrine (NE), reacts directly with the primary amine on the Lys353 residue of tau to stimulate its aggregation and facilitate its propagation.	Norepinephrine	88-102	monoamine oxidase A	Mus musculus	67-72
35217815-11	2022	In norepinephrine-treated HUVECs, we showed that trimetazidine significantly increased the phosphorylation of Akt and the synergistic nuclear translocation of Akt and HSF1, as well as the binding of Akt and HSF1 in the nucleus.	Norepinephrine	3-17	heat shock factor 1	Mus musculus	167-171
35217815-11	2022	In norepinephrine-treated HUVECs, we showed that trimetazidine significantly increased the phosphorylation of Akt and the synergistic nuclear translocation of Akt and HSF1, as well as the binding of Akt and HSF1 in the nucleus.	Norepinephrine	3-17	heat shock factor 1	Mus musculus	207-211
35006303-8	2022	We found decreased norepinephrine expression in the brains of rrn3+/- zebrafish when treated with ethanol.	Norepinephrine	19-33	RRN3 homolog, RNA polymerase I transcription factor	Danio rerio	62-66
35046893-9	2021	Specifically, this occurred via a decrease in monoamine oxidase-A (MAOA) expression, which suppressed noradrenaline degradation.	Norepinephrine	102-115	monoamine oxidase A	Rattus norvegicus	46-65
35046893-9	2021	Specifically, this occurred via a decrease in monoamine oxidase-A (MAOA) expression, which suppressed noradrenaline degradation.	Norepinephrine	102-115	monoamine oxidase A	Rattus norvegicus	67-71
2513220-0	1989	In vivo degradation of noradrenaline by MAO A in locus coeruleus of the rat.	Norepinephrine	23-36	monoamine oxidase A	Rattus norvegicus	40-45
2513220-1	1989	Depletion of noradrenaline in locus coeruleus neurons after reserpinization was prevented by clorgyline, a selective inhibitor of MAO A, but not by deprenyl, a selective inhibitor of MAO B.	Norepinephrine	13-26	monoamine oxidase A	Rattus norvegicus	130-135
2513220-2	1989	Only MAO A is therefore responsible for the degradation of homoneuronal noradrenaline in locus coeruleus nerve cells.	Norepinephrine	72-85	monoamine oxidase A	Rattus norvegicus	5-10
2512185-4	1989	After intraperitoneal injection of 3 mg of alpha-methyl-p-tyrosine, which blocked re-uptake of catecholamines in synapses, intrathecal administration of 30 ng TRH accelerated 2 times metabolic turnover of norepinephrine and dopamine in cerebral hemisphere, diencephalon and midbrain as well as norepinephrine turnover in cerebellum, pons, medulla oblongata, heart and brown adipose tissue.	Norepinephrine	205-219	thyrotropin releasing hormone	Rattus norvegicus	159-162
2512185-4	1989	After intraperitoneal injection of 3 mg of alpha-methyl-p-tyrosine, which blocked re-uptake of catecholamines in synapses, intrathecal administration of 30 ng TRH accelerated 2 times metabolic turnover of norepinephrine and dopamine in cerebral hemisphere, diencephalon and midbrain as well as norepinephrine turnover in cerebellum, pons, medulla oblongata, heart and brown adipose tissue.	Norepinephrine	294-308	thyrotropin releasing hormone	Rattus norvegicus	159-162
2605494-1	1989	This study investigated the impact of chronic adrenalectomy (ADX), and subsequent corticosterone (CORT) replacement to ADX rats, on brain levels of norepinephrine (NE) and dopamine (DA) and their extent of depletion after alpha-methyl-p-tyrosine (alpha-MpT) administration.	Norepinephrine	148-162	cortistatin	Rattus norvegicus	98-102
2764102-3	1989	In the present study, lysates of purified porcine adrenal chromaffin granules containing chromogranins A and B and a putative chromogranin B fragment bound calcium and formed aggregates in the presence of 10-20 mM calcium at pH 5-6 and at 100 mM or less KCl, NaCl, or norepinephrine.	Norepinephrine	268-282	chromogranin B	Homo sapiens	126-140
2770705-4	1989	A reciprocal relation was found to exist between inhibitory constants of 5-N-substituted amiloride analogues for monoamine oxidase A and the ratio of overflows of endogenous noradrenaline and 3,4-dihydroxyphenylethylene glycol from the isolated rat tail artery incubated in the presence of a 50 microM concentration of the analogue, when the tissue was exposed to 10 microM tyramine.	Norepinephrine	174-187	monoamine oxidase A	Rattus norvegicus	113-132
2673958-0	1989	Insulin blockade of norepinephrine tachyphylaxis in the perfused kidney.	Norepinephrine	20-34	insulin	Oryctolagus cuniculus	0-7
2559197-7	1989	In endothelium-denuded preparations, sodium nitroprusside, 8-bromo-cyclic GMP and ANF each similarly inhibited the rise in IP3 levels stimulated by noradrenaline.	Norepinephrine	148-161	natriuretic peptides A	Oryctolagus cuniculus	82-85
19210470-2	1989	We have therefore developed a radioimmunoassay for rat GHRH, and used it to investigate the modulation of GHRH release by noradrenaline from incubated rat hypothalamus in vitro.	Norepinephrine	122-135	growth hormone releasing hormone	Rattus norvegicus	106-110
19210470-7	1989	It is concluded that noradrenaline stimulates the release of GHRH at both alpha(1) and alpha(2)-adrenoceptors.	Norepinephrine	21-34	growth hormone releasing hormone	Rattus norvegicus	61-65
2786196-7	1989	In frontal cortical homogenates, MAO-A predominated in the deamination of noradrenaline both intra- and extrasynaptosomally.	Norepinephrine	74-87	monoamine oxidase A	Mus musculus	33-38
2784032-7	1989	CGRP increased plasma norepinephrine, epinephrine, and renin activity significantly at only the 2200-pmol dose.	Norepinephrine	22-36	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
2537038-7	1989	Compared with norepinephrine (NE), CGRP was 14-fold more potent at increasing rate [50% effective concentration (EC50) = 4.55 +/- 0.48 nM for CGRP and 64.8 +/- 10.5 nM for NE] and 60-fold more potent at increasing contractile force (EC50 = 3.31 +/- 0.57 nM for CGRP and 201 +/- 18 nM for NE).	Norepinephrine	14-28	calcitonin-related polypeptide alpha	Rattus norvegicus	35-39
2536425-4	1989	ANF inhibited both the electrically induced phasic contraction and electrically induced norepinephrine release in a concentration-dependent manner over the ANF concentration range of 10(-10) to 10(-7) M. ANF at a concentration of 10(-7) M had no effect on norepinephrine-induced or ATP-induced contractions.	Norepinephrine	88-102	natriuretic peptides A	Oryctolagus cuniculus	0-3
2536425-4	1989	ANF inhibited both the electrically induced phasic contraction and electrically induced norepinephrine release in a concentration-dependent manner over the ANF concentration range of 10(-10) to 10(-7) M. ANF at a concentration of 10(-7) M had no effect on norepinephrine-induced or ATP-induced contractions.	Norepinephrine	256-270	natriuretic peptides A	Oryctolagus cuniculus	0-3
2536425-5	1989	Therefore, the neuromodulatory effect of ANF in the rabbit vas deferens appears to be prejunctional, on the release of the neurotransmitters norepinephrine and ATP from the nerve terminal and not postjunctional on the smooth muscle.	Norepinephrine	141-155	natriuretic peptides A	Oryctolagus cuniculus	41-44
2787487-8	1989	Infusion of either capsaicin (1 microM) or CGRP (1 microM) reduced the increase of perfusion pressure induced by norepinephrine in isolated perfused rat kidney.	Norepinephrine	113-127	calcitonin-related polypeptide alpha	Rattus norvegicus	43-47
2616634-1	1989	To study the selectivity of calmodulin antagonists it was assumed that they should inhibit noradrenaline (NA)- and K(+)-induced contractions similarly without an accompanying inhibition of 45Ca uptake.	Norepinephrine	91-104	calmodulin 1	Rattus norvegicus	28-38
2851354-0	1988	Contribution of beta 1- and beta 2-adrenoceptors of human atrium and ventricle to the effects of noradrenaline and adrenaline as assessed with (-)-atenolol.	Norepinephrine	97-110	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	28-34
2907098-3	1988	When MAO activity was inhibited by pargyline (10 mumol/l), p-tyramine and p-octopamine had mixed excitatory-inhibitory effects on the twitches, while noradrenaline had mostly excitatory effects along the whole range of concentrations assayed (0.158-15.8 mumol/l).	Norepinephrine	150-163	monoamine oxidase A	Rattus norvegicus	5-8
2835776-1	1988	The human gene for phenylethanolamine N-methyltransferase (hPNMT), responsible for the conversion of norepinephrine to epinephrine, has been cloned and the complete nucleotide sequence has been determined.	Norepinephrine	101-115	phenylethanolamine N-methyltransferase	Homo sapiens	19-57
2835776-1	1988	The human gene for phenylethanolamine N-methyltransferase (hPNMT), responsible for the conversion of norepinephrine to epinephrine, has been cloned and the complete nucleotide sequence has been determined.	Norepinephrine	101-115	phenylethanolamine N-methyltransferase	Homo sapiens	59-64
3277568-8	1988	Plasma epinephrine concentrations did not change significantly, whereas plasma norepinephrine concentrations increased 2 1/2-fold, probably reflecting the effect of beta 2-agonism on norepinephrine release.	Norepinephrine	183-197	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	165-171
3346832-2	1988	NPY produced a concentration-dependent inhibition of nicotine-stimulated norepinephrine and epinephrine release from bovine chromaffin cells with IC50 (concentration of NPY which inhibits 50% of maximum release of catecholamines) values of 1.8 x 10(-9) M and 1.7 x 10(-9) M, respectively.	Norepinephrine	73-87	neuropeptide Y	Bos taurus	0-3
3346832-2	1988	NPY produced a concentration-dependent inhibition of nicotine-stimulated norepinephrine and epinephrine release from bovine chromaffin cells with IC50 (concentration of NPY which inhibits 50% of maximum release of catecholamines) values of 1.8 x 10(-9) M and 1.7 x 10(-9) M, respectively.	Norepinephrine	73-87	neuropeptide Y	Bos taurus	169-172
3171572-7	1988	In general, noradrenaline-containing neuronal cell body areas showed monoamine oxidase A, and 5-hydroxytryptamine-rich areas monoamine oxidase B.	Norepinephrine	12-25	monoamine oxidase A	Rattus norvegicus	69-88
2452867-4	1988	These data are consistent with the hypothesis that these MAO inhibitors stimulate melatonin synthesis by protecting norepinephrine from degradation.	Norepinephrine	116-130	monoamine oxidase A	Rattus norvegicus	57-60
3681890-7	1987	The results of this study are in agreement with previous findings for bound beta-phenylethylamines and support the conclusion that the natural substrate for PNMT, norepinephrine, has a different active site binding orientation than most known substrates and competitive inhibitors of the enzyme.	Norepinephrine	163-177	phenylethanolamine N-methyltransferase	Homo sapiens	157-161
3121388-2	1987	As expected, cold exposure or norepinephrine injection caused an increase in the amount of thermogenin mRNA.	Norepinephrine	30-44	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	91-102
3319049-7	1987	The balance of norepinephrine to epinephrine found in vesicles in these terminals would be a function of intraneuronal PNMT activity, MAO activity and reuptake which would be the major regulator of intraneuronal norepinephrine concentrations.	Norepinephrine	15-29	monoamine oxidase A	Rattus norvegicus	134-137
3683592-7	1987	The extraneuronal MAO activity was low for all three catecholamines, (-)-adrenaline, (-)-noradrenaline and dopamine (range of kMAO from 0.05 to 0.28 min-1) and declined in the order.	Norepinephrine	85-102	monoamine oxidase A	Rattus norvegicus	18-21
2885760-5	1987	Selective blockade of beta 2-adrenoceptors without affecting beta 1-adrenoceptors still enabled both adrenaline and noradrenaline to cause maximum possible increases of contractile force through beta 1-adrenoceptors.	Norepinephrine	116-129	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	22-28
2885760-7	1987	beta 2-adrenoceptors can mediate half of the maximum increase of contractile force elicited by low concentrations of adrenaline and also contribute to the increase of contractile force caused by high concentrations of noradrenaline.	Norepinephrine	218-231	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	0-6
3029657-5	1987	Agonist affinities (isoproterenol greater than epinephrine much greater than norepinephrine) were consistent with a predominance of beta-2 receptors; this predominance was confirmed by competition studies with the specific beta-2 receptor antagonist ICI 118-551 (75% beta-2, 25% beta-1).	Norepinephrine	77-91	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	132-138
2436407-2	1987	Immunoreactivity for phenylethanolamine N-methyltransferase (PNMT), the enzyme involved in the conversion of norepinephrine to epinephrine, was present in the basal epidermis and upper dermis in 16 patients with psoriasis.	Norepinephrine	109-123	phenylethanolamine N-methyltransferase	Homo sapiens	21-59
2436407-2	1987	Immunoreactivity for phenylethanolamine N-methyltransferase (PNMT), the enzyme involved in the conversion of norepinephrine to epinephrine, was present in the basal epidermis and upper dermis in 16 patients with psoriasis.	Norepinephrine	109-123	phenylethanolamine N-methyltransferase	Homo sapiens	61-65
20501080-0	1987	Norepinephrine metabolism in the cerebellum of the purkinje cell degeneration (pcd) mutant mouse.	Norepinephrine	0-14	ATP/GTP binding protein 1	Mus musculus	51-77
3542630-7	1986	Moreover, LHRH models 1 and 3 also retained the neuromodulatory effects of LHRH on cellular responses to norepinephrine and serotonin.	Norepinephrine	105-119	gonadotropin releasing hormone 1	Homo sapiens	10-14
3542630-7	1986	Moreover, LHRH models 1 and 3 also retained the neuromodulatory effects of LHRH on cellular responses to norepinephrine and serotonin.	Norepinephrine	105-119	gonadotropin releasing hormone 1	Homo sapiens	75-79
3822124-6	1986	The kinetics of the oxidase are similar to those of monoamine oxidase type A reported in other tissues including the adrenergic neuron, having apparent Km values of 400, 280, 170 and 227 microM for noradrenaline, dopamine, serotonin and tyramine.	Norepinephrine	198-211	monoamine oxidase A	Rattus norvegicus	52-76
2430461-7	1986	Postincubation changes in the response to norepinephrine, either in the presence or absence of external Ca2+, depended on both the dose of norepinephrine and the level of Mg2+ in the incubation medium.	Norepinephrine	42-56	mucin 7, secreted	Homo sapiens	171-174
3533396-5	1986	Significant increments above baseline renin release were seen with the stimuli of adrenaline, noradrenaline and isoprenaline.	Norepinephrine	94-107	renin	Rattus norvegicus	38-43
3096034-5	1986	During TRH treatment, brain norepinephrine (NE) and dopamine (DA) release was accelerated 2- to 4-fold.	Norepinephrine	28-42	thyrotropin releasing hormone	Rattus norvegicus	7-10
3761316-7	1986	From the findings of this study, it appears that norepinephrine has a different active site binding orientation than most known substrates and competitive inhibitors of PNMT.	Norepinephrine	49-63	phenylethanolamine N-methyltransferase	Homo sapiens	169-173
2877020-10	1986	It is concluded that all of the effects of splanchnic nerve stimulation on insulin and PP secretion can be explained by interactions of norepinephrine with excitatory beta-receptors on PP-cells and inhibitory receptors on the insulin cells.	Norepinephrine	136-150	insulin	Sus scrofa	75-82
3090211-4	1986	The increased rCBF in the cortex treated with 6-OHDA was suppressed by the iontophoretic replacement of noradrenaline (NA) to the CA-depleted cortex.	Norepinephrine	104-117	CCAAT/enhancer binding protein zeta	Rattus norvegicus	14-18
3742029-2	1986	Distinct effects of these compounds on the deamination of serotonin and norepinephrine (MAO-A substrates); 2-phenylethylamine (selective MAO-B substrate); tyramine and dopamine (MAO-A and MAO-B substrates) are shown.	Norepinephrine	72-86	monoamine oxidase A	Rattus norvegicus	88-93
3742029-3	1986	It was demonstrated that among all the compounds studied moclobamide appeared to be the most active and selective inhibitor of MAO-A: at a concentration of 100 microM it caused a 100% inhibition of serotonin and norepinephrine deamination, which might be explained by the presence of C1 atom in the para-position of benzene ring in moclobamide molecule.	Norepinephrine	212-226	monoamine oxidase A	Rattus norvegicus	127-132
3486739-5	1986	Plasma noradrenaline (nmol/l) was lower in the PIH group compared with control patients in both semi-recumbent (1.11 +/- 0.53 vs 1.98 +/- 0.96, P less than 0.001) and standing positions (1.31 +/- 0.65 vs 2.57 +/- 1.27, P less than 0.005).	Norepinephrine	7-20	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	47-50
3486739-6	1986	Five days post partum, plasma noradrenaline had risen in the PIH group compared with pregnant values in semi-recumbent (1.65 +/- 1.0 vs 1.11 +/- 0.52, P less than 0.05) and standing positions (2.46 +/- 1.5 vs 1.31 +/- 0.65, P less than 0.05).	Norepinephrine	30-43	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	61-64
3013594-5	1986	Rat CGRP caused relaxation of splenic strips, precontracted with noradrenaline; the EC50 was 50 nM.	Norepinephrine	65-78	calcitonin-related polypeptide alpha	Rattus norvegicus	4-8
3013594-9	1986	After tachyphylaxis to CGRP, the response to noradrenaline was intact, while the positive chronotropic and inotropic effects of capsaicin were suppressed.	Norepinephrine	45-58	calcitonin-related polypeptide alpha	Rattus norvegicus	23-27
3086955-5	1986	These findings suggest that the increased blood pressure in SHRSP may be related to increased plasma norepinephrine concentration caused by a decrease in degradation enzyme, MAO.	Norepinephrine	101-115	monoamine oxidase A	Rattus norvegicus	174-177
3486773-3	1986	In the presence of the vasoconstrictor noradrenaline (10(-5) M), rat alpha-CGRP was about 10 times as potent as either human alpha-CGRP or sodium nitroprusside as a vasodilator in the rat mesenteric vasculature.	Norepinephrine	39-52	calcitonin-related polypeptide alpha	Rattus norvegicus	75-79
3486773-3	1986	In the presence of the vasoconstrictor noradrenaline (10(-5) M), rat alpha-CGRP was about 10 times as potent as either human alpha-CGRP or sodium nitroprusside as a vasodilator in the rat mesenteric vasculature.	Norepinephrine	39-52	calcitonin-related polypeptide alpha	Rattus norvegicus	131-135
3004914-9	1986	It is concluded that there is a close temporal relationship between changes in ACTH, AVP, and norepinephrine concentrations.	Norepinephrine	94-108	pro-opiomelanocortin	Equus caballus	79-83
3712451-6	1986	Norepinephrine concentration, as a function of crude tissue mass, was significantly reduced in both the scarred tissues and the non-scarred tissues surrounding the scar in the discrete infarction model but was significantly reduced only in non-scarred tissues adjacent to the dense scar when expressed as a function of myosin heavy chain.	Norepinephrine	0-14	MYHC	Felis catus	319-337
3951433-5	1986	Transport occurs through the monoamine transporter since it is blocked by the same inhibitors, tetrabenazine and reserpine, and also by the transporter substrates noradrenaline and serotonin.	Norepinephrine	163-176	solute carrier family 18 member A2	Bos taurus	29-50
3080585-0	1986	Contribution of Ca++ and calmodulin to the action of norepinephrine on renal prostaglandin synthesis and vascular tone.	Norepinephrine	53-67	calmodulin 1	Rattus norvegicus	25-35
3010387-9	1986	NPY and PYY potentiated the response to noradrenaline in the artery, as well as the response to histamine in the vein.	Norepinephrine	40-53	peptide YY	Oryctolagus cuniculus	8-11
3468755-0	1986	Possible central mediation of rCBF response to systemic norepinephrine.	Norepinephrine	56-70	CCAAT/enhancer binding protein zeta	Rattus norvegicus	30-34
3462329-8	1986	Norepinephrine, epinephrine and dopamine would stimulate GnRH secretion.	Norepinephrine	0-14	gonadotropin releasing hormone 1	Homo sapiens	57-61
3746287-7	1986	These data suggest that CDP-choline enhances norepinephrine release, and that this action may be mediated by more than just its choline content.	Norepinephrine	45-59	cut-like homeobox 1	Rattus norvegicus	24-27
3005903-2	1986	This was achieved by measuring their ability to protect MAO from irreversible inhibition by phenelzine, determined by the deaminating activity of synaptosomal preparations in the absence and presence of maprotiline, a selective inhibitor of the uptake of noradrenaline, or of amfonelic acid, a potent inhibitor of the uptake of dopamine, with small (0.25 microM) concentrations of [14C]noradrenaline or [14C]dopamine as substrate.	Norepinephrine	255-268	monoamine oxidase A	Rattus norvegicus	56-59
3005903-4	1986	Since the inhibitors of the uptake of noradrenaline, desipramine and CPP 199 antagonized this preference for noradrenergic MAO it is concluded that these MAO inhibitors are accumulated in the noradrenergic neurones by the membranal uptake carrier.	Norepinephrine	38-51	monoamine oxidase A	Rattus norvegicus	123-126
3005903-4	1986	Since the inhibitors of the uptake of noradrenaline, desipramine and CPP 199 antagonized this preference for noradrenergic MAO it is concluded that these MAO inhibitors are accumulated in the noradrenergic neurones by the membranal uptake carrier.	Norepinephrine	38-51	monoamine oxidase A	Rattus norvegicus	154-157
20493079-12	1986	In contrast MAO-A showed a significantly lower K(m) and a higher maximum velocity towards noradrenaline in rat brain.	Norepinephrine	90-103	monoamine oxidase A	Rattus norvegicus	12-17
2867805-2	1985	The specific activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of norepinephrine (NE), increases during this time and is subject to transsynaptic regulation by the preganglionic inputs.	Norepinephrine	97-111	tyrosine hydroxylase	Rattus norvegicus	25-45
2867805-2	1985	The specific activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of norepinephrine (NE), increases during this time and is subject to transsynaptic regulation by the preganglionic inputs.	Norepinephrine	97-111	tyrosine hydroxylase	Rattus norvegicus	47-49
2908820-9	1985	ICI 118,551 and propranolol equally blocked the beta 2-receptor mediated fall in diastolic pressure and the rise in noradrenaline.	Norepinephrine	116-129	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	48-54
2866474-6	1985	NPY constricted the uterine artery perfused in vitro, whilst VIP dilated uterine arteries preconstricted with noradrenaline or NPY.	Norepinephrine	110-123	VIP peptides	Cavia porcellus	61-64
2420296-1	1985	The present study evaluated the role of Na+-K+ -ATPase stimulation in the relaxant response to synthetic atrial natriuretic factor (atriopeptin II; ANF) in norepinephrine (0.18 microM)-contracted rabbit aorta.	Norepinephrine	156-170	natriuretic peptides A	Oryctolagus cuniculus	148-151
2420296-4	1985	Likewise, ANF (10(-7) and 5 X 10(-9) M) elicited significantly less relaxation of aortic rings contracted with norepinephrine in a physiological salt solution containing zero KCl.	Norepinephrine	111-125	natriuretic peptides A	Oryctolagus cuniculus	10-13
2934640-0	1985	Depletion of noradrenaline in the hypothalamus reduces the febrile responses induced by prostaglandin E2, thyrotropin-releasing hormone and beta-endorphin in rats.	Norepinephrine	13-26	thyrotropin releasing hormone	Rattus norvegicus	106-135
2934640-3	1985	Furthermore, the hyperthermic responses induced by prostaglandin E2, thyrotropin-releasing hormone, or beta-endorphin were greatly attenuated after selective depletion of noradrenaline in the hypothalamus in rats.	Norepinephrine	171-184	thyrotropin releasing hormone	Rattus norvegicus	69-98
2934640-5	1985	The data indicate that either prostaglandin E2, thyrotropin-releasing hormone or beta-endorphin may act through the endogenous release of noradrenaline from the hypothalamus to induce hyperthermic responses in rats.	Norepinephrine	138-151	thyrotropin releasing hormone	Rattus norvegicus	48-77
3893993-3	1985	Immunohistochemically, NPY immunoreactivity was detected in norepinephrine containing chromaffin cells and also in nerve fibers crossing through adrenal cortex and medulla.	Norepinephrine	60-74	neuropeptide Y	Bos taurus	23-26
2863199-3	1985	Infusion of noradrenaline, an alpha-adrenergic agonist, inhibited basal and vasoactive intestinal polypeptide (VIP) stimulated flow rate and output of EGF from Brunner"s glands and increased the amount of EGF in the tissue.	Norepinephrine	12-25	epidermal growth factor like 1	Rattus norvegicus	151-154
2863199-3	1985	Infusion of noradrenaline, an alpha-adrenergic agonist, inhibited basal and vasoactive intestinal polypeptide (VIP) stimulated flow rate and output of EGF from Brunner"s glands and increased the amount of EGF in the tissue.	Norepinephrine	12-25	epidermal growth factor like 1	Rattus norvegicus	205-208
3906634-3	1985	Noradrenaline and dopamine lowered the LH-RH level in intact animals in the area of arcuate nuclei and MBH synaptosomes, the LH level in the blood increased under the influence of noradrenaline only.	Norepinephrine	0-13	gonadotropin releasing hormone 1	Homo sapiens	39-44
2992292-1	1985	Vasoactive intestinal polypeptide (VIP; over 10(-13) M) inhibited the norepinephrine (NE)-induced contraction evoked from the rabbit mesenteric artery.	Norepinephrine	70-84	VIP peptides	Oryctolagus cuniculus	0-33
2992292-1	1985	Vasoactive intestinal polypeptide (VIP; over 10(-13) M) inhibited the norepinephrine (NE)-induced contraction evoked from the rabbit mesenteric artery.	Norepinephrine	70-84	VIP peptides	Oryctolagus cuniculus	35-38
2996548-2	1985	In gonadotropin releasing hormone desensitized testis all the other treated compounds namely, luteinizing hormone, follicle stimulating hormone, prostaglandin F2 alpha, norepinephrine and cyclic AMP caused stimulation of ornithine decarboxylase activity.	Norepinephrine	169-183	ornithine decarboxylase 1	Homo sapiens	221-244
2863358-4	1985	It was found that (-)-noradrenaline was approximately 10-fold more selective for the beta 1- as opposed to the beta 2-adrenoceptor in the pharmacological studies.	Norepinephrine	18-35	beta-2 adrenergic receptor	Cavia porcellus	111-130
2997557-2	1985	P11 shifted noradrenaline concentration-effect curves to the right.	Norepinephrine	12-25	S100 calcium binding protein A10	Rattus norvegicus	0-3
3160963-0	1985	Serotonin and norepinephrine-dependent effects of fenfluramine on plasma renin activity in conscious male rats.	Norepinephrine	14-28	renin	Rattus norvegicus	73-78
3160963-7	1985	Pretreatment with the blocker of the uptake of norepinephrine, desipramine did not prevent the initial (30 min) effect but completely prevented the delayed (4 hr) effect of fenfluramine on plasma renin activity.	Norepinephrine	47-61	renin	Rattus norvegicus	196-201
3971933-3	1985	When the sympathomimetics norepinephrine, epinephrine, and isoproterenol were added to the medium, androgen production in response to hCG was enhanced by 100-300%.	Norepinephrine	26-40	hypertrichosis 2 (generalised, congenital)	Homo sapiens	134-137
3924795-2	1985	The effects of a TRH (thyrotropin-releasing hormone) analog, DN-1417 (gamma-butyrolactone-gamma-carbonyl-L-histidyl-L-prolinamide citrate), on the levels of norepinephrine (NE), dopamine (DA), serotonin (5-HT) and the metabolites in the various brain regions of rats were determined by means of high performance liquid chromatography with electrochemical detection.	Norepinephrine	157-171	thyrotropin releasing hormone	Rattus norvegicus	22-51
3974415-1	1985	Norepinephrine (NE) binds extensively to protein that copurifies with phenylethanolamine-N-methyltransferase (PNMT) prepared from bovine adrenal medulla.	Norepinephrine	0-14	phenylethanolamine N-methyltransferase	Bos taurus	70-108
3974415-1	1985	Norepinephrine (NE) binds extensively to protein that copurifies with phenylethanolamine-N-methyltransferase (PNMT) prepared from bovine adrenal medulla.	Norepinephrine	0-14	phenylethanolamine N-methyltransferase	Bos taurus	110-114
2412251-1	1985	The effects of cimoxatone, a reversible inhibitor of monoamine oxidase type A (MAO-A), on the deaminated metabolites of norepinephrine, dopamine, and serotonin were examined in continuously collected rhesus monkey cerebrospinal fluid (CSF).	Norepinephrine	120-134	monoamine oxidase A	Macaca mulatta	79-84
6547992-1	1984	Neuropeptide Y, a recently isolated neuropeptide exhibited norepinephrine-like effects on LH release after intracerebroventricular administration at doses from 0.5 to 10 micrograms.	Norepinephrine	59-73	pyroglutamylated RFamide peptide	Rattus norvegicus	36-48
6147403-3	1984	In brain regions containing endogenous epinephrine (medulla-pons and hypothalamus), chronic treatment with PNMT inhibitors produced: 1) reductions of epinephrine content, 2) elevation of tyrosine hydroxylase activity and 3) elevation of alpha-1 and particularly alpha-2 adrenergic receptor radioligand binding sites; neither norepinephrine turnover nor beta adrenergic receptor binding was affected.	Norepinephrine	325-339	phenylethanolamine N-methyltransferase	Homo sapiens	107-111
6147403-4	1984	In brain regions devoid of endogenous epinephrine (cerebellum, frontal cortex and hippocampus), chronic treatment with PNMT inhibitors produced 1) a variable increase in tyrosine hydroxylase activity (cerebellum only) and 2) a reduction in norepinephrine turnover; neither alpha or beta adrenergic receptor binding was altered.	Norepinephrine	240-254	phenylethanolamine N-methyltransferase	Homo sapiens	119-123
6540055-2	1984	This atrial natriuretic factor (ANF) produced a potent, dose-dependent relaxant effect on rabbit and rat arterial strips previously made to contract by application of either norepinephrine (NE) or angiotensin II.	Norepinephrine	174-188	natriuretic peptides A	Oryctolagus cuniculus	5-30
6540055-2	1984	This atrial natriuretic factor (ANF) produced a potent, dose-dependent relaxant effect on rabbit and rat arterial strips previously made to contract by application of either norepinephrine (NE) or angiotensin II.	Norepinephrine	174-188	natriuretic peptides A	Oryctolagus cuniculus	32-35
6742189-6	1984	Plasma and urinary epinephrine and norepinephrine are detected by conversion to metanephrine with the enzymes catechol-O-methyl-transferase (COMT) and phenylethanolamine-N-methyltransferase (PNMT).	Norepinephrine	35-49	catechol-O-methyltransferase	Homo sapiens	110-139
6742189-6	1984	Plasma and urinary epinephrine and norepinephrine are detected by conversion to metanephrine with the enzymes catechol-O-methyl-transferase (COMT) and phenylethanolamine-N-methyltransferase (PNMT).	Norepinephrine	35-49	catechol-O-methyltransferase	Homo sapiens	141-145
6742189-6	1984	Plasma and urinary epinephrine and norepinephrine are detected by conversion to metanephrine with the enzymes catechol-O-methyl-transferase (COMT) and phenylethanolamine-N-methyltransferase (PNMT).	Norepinephrine	35-49	phenylethanolamine N-methyltransferase	Homo sapiens	151-189
6742189-6	1984	Plasma and urinary epinephrine and norepinephrine are detected by conversion to metanephrine with the enzymes catechol-O-methyl-transferase (COMT) and phenylethanolamine-N-methyltransferase (PNMT).	Norepinephrine	35-49	phenylethanolamine N-methyltransferase	Homo sapiens	191-195
6433837-6	1984	PEP was associated with increased myocardial noradrenaline secretion (-3.1 +/- 31.5 ng/min under basal conditions to 30.2 +/- 42.8 ng/min, p less than 0.05).	Norepinephrine	45-58	prolyl endopeptidase	Homo sapiens	0-3
6433837-7	1984	Therefore, the inotropic effect of PEP imposes a high metabolic demand and is associated with increased myocardial noradrenaline secretion.	Norepinephrine	115-128	prolyl endopeptidase	Homo sapiens	35-38
6095345-3	1984	In Experiment 2, it was shown that injections of 10 and 20 nmoles of noradrenaline (NA) into the ABL increased the time spent eating familiar food in the food preference test.	Norepinephrine	69-82	ABL proto-oncogene 1, non-receptor tyrosine kinase	Rattus norvegicus	97-100
6738815-4	1984	These results, which are similar to those reported for centrally administered norepinephrine, raise the possibility that pancreatic polypeptide, or a similar peptide, may participate in the physiologic regulation of LH release, either independently or perhaps as a neuromodulator or a cotransmitter with catecholamines.	Norepinephrine	78-92	pancreatic polypeptide	Rattus norvegicus	121-143
6203542-1	1984	The effects of acute and chronic administration of clorgyline, an irreversible inhibitor of monoamine oxidase type A (MAO-A), on the deaminated metabolites of norepinephrine, dopamine and serotonin were examined in rhesus monkey cerebrospinal fluid (CSF).	Norepinephrine	159-173	monoamine oxidase A	Macaca mulatta	118-123
6203542-7	1984	They differ from several in vitro studies which indicate a primary role of MAO-A in the metabolism of serotonin and of MAO-B in norepinephrine degradation in primate brain.	Norepinephrine	128-142	monoamine oxidase A	Macaca mulatta	75-80
6368797-1	1984	It is well known that norepinephrine released from the renal nerves stimulates the secretion of renin by a beta adrenergic mechanism.	Norepinephrine	22-36	renin	Rattus norvegicus	96-101
6315886-8	1984	When linoleic acid-treated slices were washed with Krebs-Ringer containing defatted bovine serum albumin, both enhancement of the response to norepinephrine and the amount of [14C]linoleic acid incorporated in a free form significantly diminished.	Norepinephrine	142-156	albumin	Cavia porcellus	91-104
6663484-0	1983	Coil leads to helix transition in polyadenylic acid induced by the binding of epinephrine, norepinephrine, and isoproterenol: circular dichroism study.	Norepinephrine	91-105	coilin	Homo sapiens	0-4
6663484-1	1983	A circular dichroism spectropolarimetric study on the conformation of polyadenylic acid (poly A) in neutral solutions demonstrated a coil leads to helix transition induced by intercalative binding of critical amounts of epinephrine, norepinephrine, and isoproterenol relative to poly A.	Norepinephrine	233-247	coilin	Homo sapiens	133-137
6139495-13	1983	The addition of DN-1417 (10(-4) M) or TRH (10(-3) M) significantly enhanced the spontaneous [3H]-dopamine and [3H]-norepinephrine release from the superfused slices of the rat nucleus accumbens and cerebral cortex in vitro.	Norepinephrine	115-129	thyrotropin releasing hormone	Rattus norvegicus	38-41
6195533-1	1983	CGP 11305 A [4-(5-methoxy-7-bromo-benzofuranyl-2)piperidine HCl), a reversible, selective inhibitor of MAO A, increased the levels of rat brain noradrenaline, dopamine, and serotonin dose-dependently and to approximately the same extent.	Norepinephrine	144-157	monoamine oxidase A	Rattus norvegicus	103-108
6224835-3	1983	These findings suggest that at least for depressed men, central norepinephrine deficiency may be the neurobiological substrate of blunted TSH responses to TRH.	Norepinephrine	64-78	thyrotropin releasing hormone	Homo sapiens	155-158
6633672-1	1983	In both rat brain and heart, noradrenaline and 5-hydroxytryptamine are metabolised predominantly by monoamine oxidase-A.	Norepinephrine	29-42	monoamine oxidase A	Rattus norvegicus	100-119
6137369-3	1983	Infusion of the beta-adrenoceptor agonists isoprenaline (non-selective) and salbutamol (beta 2-selective), but not prenalterol (beta 1-selective) caused dose-dependent increments in plasma noradrenaline.	Norepinephrine	189-202	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	88-94
6190642-4	1983	When infused into the third ventricle, acetylcholine (50 micrograms), substance P (5 micrograms), dopamine (5 micrograms), and norepinephrine (2.5 micrograms) increased plasma GH levels in the deafferented rats but not in the controls, while 5-hydroxytryptamine (5 micrograms) caused a rise of plasma GH levels in both groups.	Norepinephrine	127-141	gonadotropin releasing hormone receptor	Rattus norvegicus	176-178
6190642-4	1983	When infused into the third ventricle, acetylcholine (50 micrograms), substance P (5 micrograms), dopamine (5 micrograms), and norepinephrine (2.5 micrograms) increased plasma GH levels in the deafferented rats but not in the controls, while 5-hydroxytryptamine (5 micrograms) caused a rise of plasma GH levels in both groups.	Norepinephrine	127-141	gonadotropin releasing hormone receptor	Rattus norvegicus	301-303
6190642-6	1983	We suggest that acetylcholine, substance P, norepinephrine and dopamine, but not histamine, may increase the secretion of GHRF acting either directly upon the GHRF cells or on neural circuits impinging upon them.	Norepinephrine	44-58	growth hormone releasing hormone	Rattus norvegicus	122-126
6190642-6	1983	We suggest that acetylcholine, substance P, norepinephrine and dopamine, but not histamine, may increase the secretion of GHRF acting either directly upon the GHRF cells or on neural circuits impinging upon them.	Norepinephrine	44-58	growth hormone releasing hormone	Rattus norvegicus	159-163
6300586-4	1983	Agonist potency isoproterenol greater than epinephrine greater than norepinephrine indicated that early human placenta contains an adrenergic receptor of beta-2 subtype.	Norepinephrine	68-82	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	154-160
6402625-3	1983	The action of AVP was attenuated by a dose of 6-OHDA which significantly lowered brain norepinephrine, but not dopamine levels, suggesting that the maintenance of ethanol tolerance by AVP may require the presence of intact noradrenergic pathways in brain.	Norepinephrine	87-101	arginine vasopressin	Mus musculus	14-17
6299476-4	1983	A cyclic AMP phosphodiesterase inhibitor, 3-isobutyl-1-methyl xanthine (IBMX), enhanced the elevation of CAT activity by L-norepinephrine.	Norepinephrine	121-137	choline acetyltransferase	Mus musculus	105-108
6299476-5	1983	These results indicate that L-norepinephrine stimulated the synthesis of CAT molecules via the action of cyclic AMP.	Norepinephrine	28-44	choline acetyltransferase	Mus musculus	73-76
6299476-6	1983	The pretreatment of cells with 5-fluoro-2"-deoxyuridine (FdU) markedly diminished the numbers of satellite cells and, in parallel, the responses of CAT activity to L-norepinephrine.	Norepinephrine	164-180	choline acetyltransferase	Mus musculus	148-151
6299476-10	1983	These observations indicate that the stimulatory effect of L-norepinephrine on CAT activity is mostly, if not only, mediated via the interaction with satellite cells, and that the increase of CAT activity by L-norepinephrine is based on a mechanism different from that of co-cultures with heart muscle cells.	Norepinephrine	59-75	choline acetyltransferase	Mus musculus	79-82
6299476-10	1983	These observations indicate that the stimulatory effect of L-norepinephrine on CAT activity is mostly, if not only, mediated via the interaction with satellite cells, and that the increase of CAT activity by L-norepinephrine is based on a mechanism different from that of co-cultures with heart muscle cells.	Norepinephrine	208-224	choline acetyltransferase	Mus musculus	192-195
6304562-5	1983	Considering that MAO A for most part is intraneuronal and its substrates noradrenaline (NA) and serotonin (5-HT) have been implicated in the pathogenesis of depressive illness, it would appear that selective A inhibitors would be more effective as antidepressants.	Norepinephrine	73-86	monoamine oxidase A	Rattus norvegicus	17-22
6132826-1	1983	Noradrenaline produced a stereospecific and dose-related stimulation of cyclic GMP levels in incubated mouse cerebellar slices.	Norepinephrine	0-13	5'-nucleotidase, cytosolic II	Mus musculus	79-82
6831790-4	1983	Free norepinephrine (NE) and epinephrine (E) serum levels were higher, before HD, in uremic patients (301 +/- 31 and 139 +/- 43 pg ml-1) than in normal individuals (206 +/- 14 and 34 +/- 4 pg ml-1).	Norepinephrine	5-19	interleukin 17F	Homo sapiens	131-135
6186863-0	1983	Inhibitory effect of circulating norepinephrine on epinephrine-induced renin secretion.	Norepinephrine	33-47	renin	Rattus norvegicus	71-76
6131147-8	1983	Prostaglandin E2, isoprenaline, adenosine-5"-triphosphate and VIP relaxed the noradrenaline contracted rabbit urethra with a time course different from that of the electrically induced relaxation.	Norepinephrine	78-91	VIP peptides	Oryctolagus cuniculus	62-65
6306233-15	1983	These results strongly support the possible key role that the redistribution and influx of Ca2+ may play in lipolysis induced by epinephrine, norepinephrine, caffeine and ACTH, and further suggest that calmodulin may affect lipolysis.	Norepinephrine	142-156	calmodulin 1	Rattus norvegicus	202-212
6856588-1	1983	The effect of monoamine oxidase (MAO) inhibition on maternofetal transfer of noradrenaline (NA) has been investigated in vitro using dual perfusion of isolated human placental lobules.	Norepinephrine	77-90	monoamine oxidase A	Rattus norvegicus	33-36
6316394-1	1983	The consequences of selective monoamine oxidase (MAO) inhibition on the norepinephrine(NE)-sensitive adenylate cyclase system were determined in slices of rat cerebral cortex.	Norepinephrine	72-86	monoamine oxidase A	Rattus norvegicus	49-52
7172441-0	1982	Radioenzymatic assay of plasma adrenaline and noradrenaline: evidence for a catechol-O-methyltransferase (COMT) inhibiting factor associated with essential hypertension.	Norepinephrine	46-59	catechol-O-methyltransferase	Homo sapiens	76-104
7172441-0	1982	Radioenzymatic assay of plasma adrenaline and noradrenaline: evidence for a catechol-O-methyltransferase (COMT) inhibiting factor associated with essential hypertension.	Norepinephrine	46-59	catechol-O-methyltransferase	Homo sapiens	106-110
6751008-2	1982	gamma-Trace was demonstrated by the immunohistochemical peroxidase/anti-peroxidase technique to occur in normal chromaffin cells of the adrenal medulla from African green monkey, capuchin monkey and beagle dog and in the cells of a norepinephrine-producing human phaeochromocytoma.	Norepinephrine	232-246	cystatin C	Homo sapiens	0-11
7115420-1	1982	Phenylethanolamine-N-methyltransferase (PNMT) catalyzes the conversion of norepinephrine to epinephrine.	Norepinephrine	74-88	phenylethanolamine N-methyltransferase	Bos taurus	0-38
7115420-1	1982	Phenylethanolamine-N-methyltransferase (PNMT) catalyzes the conversion of norepinephrine to epinephrine.	Norepinephrine	74-88	phenylethanolamine N-methyltransferase	Bos taurus	40-44
6122719-4	1982	Tyramine, norepinephrine, and epinephrine also stimulate the cyclase, probably via the octopamine receptor.	Norepinephrine	10-24	Octopamine-Tyramine receptor	Drosophila melanogaster	87-106
6124306-7	1982	Reductions in norepinephrine levels in the heart and spleen of adult rabbits born to anti-NGF producing mothers were greater than in small intestine.	Norepinephrine	14-28	beta-nerve growth factor	Oryctolagus cuniculus	90-93
6278463-1	1982	Noradrenaline (NA) and isopropyladrenaline in a dose of 11 microM/kg were shown to activate in vivo Na+, K+-ATPase and Mg2+-ATPase in the mouse renal microsomal fraction.	Norepinephrine	0-13	dynein, axonemal, heavy chain 8	Mus musculus	108-114
6278463-1	1982	Noradrenaline (NA) and isopropyladrenaline in a dose of 11 microM/kg were shown to activate in vivo Na+, K+-ATPase and Mg2+-ATPase in the mouse renal microsomal fraction.	Norepinephrine	0-13	dynein, axonemal, heavy chain 8	Mus musculus	124-130
7315912-1	1981	The enzyme phenylethanolamine-N-methyl transferase (PNMT) converts norepinephrine (NE) to epinephrine (E), and cathechol-O-methyl transferase (COMT) and monoamine oxidase (MAO) both metabolize NE and E. We were able to measure the activity of these enzymes in myometrial and endometrial samples obtained from 27 pregnant women between 32 and 40 weeks" gestation at the time of cesarean section.	Norepinephrine	67-81	phenylethanolamine N-methyltransferase	Homo sapiens	11-50
7315912-1	1981	The enzyme phenylethanolamine-N-methyl transferase (PNMT) converts norepinephrine (NE) to epinephrine (E), and cathechol-O-methyl transferase (COMT) and monoamine oxidase (MAO) both metabolize NE and E. We were able to measure the activity of these enzymes in myometrial and endometrial samples obtained from 27 pregnant women between 32 and 40 weeks" gestation at the time of cesarean section.	Norepinephrine	67-81	phenylethanolamine N-methyltransferase	Homo sapiens	52-56
6117605-8	1981	In vitro studies showed that the spontaneous outflow of noradrenaline from hypothalamic slices was accelerated by GYKI 11679 in a dose-dependent manner in a concentration range of 10(-5) to 10(-7) M. In a 10-fold higher range, GYKI 11679 produced inhibition of both the hypothalamic and the adrenal tyrosine hydroxylase activity but did not alter DOPA-decarboxylase, dopamine-beta-hydroxylase, or monoamine oxidase activities.	Norepinephrine	56-69	dopa decarboxylase	Rattus norvegicus	347-365
6126856-3	1981	This activity was stimulated (in the presence as well as in the absence of added GTP) by D,L-isoproterenol, L-epinephrine and L-norepinephrine, the relative potency of these agonists being compatible with the existence of beta-adrenoceptors of the beta2 subtype.	Norepinephrine	126-142	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	248-253
6264031-1	1981	The effect of ascorbic acid and noradrenaline on the inhibition of synaptosomal membrane ATPase by vanadate has been studied.	Norepinephrine	32-45	dynein axonemal heavy chain 8	Homo sapiens	89-95
6262331-5	1981	Stimulation of the release of ACTH-, endorphin-, lipotropin-, and 16k fragment immunoreactive material by norepinephrine was fully blocked by cobalt; by this criterion, stimulated release was calcium dependent.	Norepinephrine	106-120	pro-opiomelanocortin-alpha	Mus musculus	30-34
6262331-8	1981	The stimulation of secretion by norepinephrine and inhibition of secretion by cobalt was restricted to the lower molecular weight products derived from pro-ACTH/endorphin: glycosylated and nonglycosylated ACTH(1-39); beta-lipotropin, beta-endorphin, and gamma-lipotropin; and 16k fragment.	Norepinephrine	32-46	pro-opiomelanocortin-alpha	Mus musculus	156-160
6790402-0	1981	Thyrotropin-releasing hormone increases plasma norepinephrine in man.	Norepinephrine	47-61	thyrotropin releasing hormone	Homo sapiens	0-29
6790402-6	1981	The blood pressure changes associated with TRH administration may be related to norepinephrine release.	Norepinephrine	80-94	thyrotropin releasing hormone	Homo sapiens	43-46
6170594-8	1981	The amylase release induced by norepinephrine, mediated via beta1-adrenoceptor, is depressed by DSCG.	Norepinephrine	31-45	adrenoceptor beta 1	Homo sapiens	60-78
7470856-9	1980	Since the origins and terminations of both these pathways correspond closely to the locations and patterns of terminations of noradrenaline-containing neurons, demonstrated here with DbetaH immunocytochemistry, norepinephrine (or epinephrine) is suggested to be the transmitter in both these descending systems.	Norepinephrine	126-139	dopamine beta-hydroxylase	Macaca fascicularis	183-189
7470856-9	1980	Since the origins and terminations of both these pathways correspond closely to the locations and patterns of terminations of noradrenaline-containing neurons, demonstrated here with DbetaH immunocytochemistry, norepinephrine (or epinephrine) is suggested to be the transmitter in both these descending systems.	Norepinephrine	211-225	dopamine beta-hydroxylase	Macaca fascicularis	183-189
6248606-4	1980	The agonist pattern of adenylate cyclase activation suggested the presence of beta-2 adrenergic receptors, since isoproterenol with a Kact of 0.7 microM was more potent than epinephrine (Kact = 8.5 microM) or norepinephrine (Kact = 90 microM).	Norepinephrine	209-223	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	78-84
6248884-1	1980	The accumulations of cyclic AMP elicited by norepinephrine in slices of rat cerebral cortex or hypothalamus were markedly reduced after incubations with prostaglandin synthetase (8,11,14-eicosatrienoate, hydrogen-donor:oxygen oxidoreductase, EC 1.14.99.1) inhibitors such as indomethacin, aspirin, flufenamic acid, and acetoaminophen.	Norepinephrine	44-58	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	226-240
6998806-10	1980	This study suggest that high concentrations of norepinephrine, dopamine, and serotonin in the pancreatic islets can decrease glucose-stimulated insulin secretion.	Norepinephrine	47-61	insulin	Mesocricetus auratus	144-151
6153144-1	1980	Epinephrine, norepinephrine, and isoproterenol produced dose-dependent stimulation of ornithine decarboxylase (EC 4.1.1.17) activity in isolated porcine granulosa cells maintained under defined conditions in vitro.	Norepinephrine	13-27	ornithine decarboxylase 1	Homo sapiens	86-109
6765927-0	1980	Thyrotropin-releasing hormone and serotonin secretion from frog skin are stimulated by norepinephrine.	Norepinephrine	87-101	thyrotropin releasing hormone	Homo sapiens	0-29
44853-3	1979	The ATP-induced uptake of noradrenaline was also sensitive to the potential since imposing a transient negative potential onto the positive potential generated by the membrane ATPase induced a latency in this transport.	Norepinephrine	26-39	dynein axonemal heavy chain 8	Homo sapiens	176-182
40668-6	1979	Intracerebral NGF administeration enhanced the response to D-amphetamine 15 days later in rats without lesions, and also appeared to result in increased turnover of brain norepinephrine and serotonin at 3, but not 15, days postadministration.	Norepinephrine	171-185	nerve growth factor	Rattus norvegicus	14-17
41729-3	1979	Concentrations of noradrenaline, adrenaline and methoxamine of 10(-6), 10(-5), 10(-4) and 10(-3) M caused significant dose-related inhibition of renin release.	Norepinephrine	18-31	renin	Rattus norvegicus	145-150
487592-2	1979	Noradrenaline and adrenaline are converted to their O-methylated analogues, normethanephrine and metanephrine, by the enzyme catechol O-methyltransferase in the presence of tritiated S-adenosyl-L-methionine.	Norepinephrine	0-13	catechol-O-methyltransferase	Homo sapiens	125-153
119692-7	1979	TRH(10(-4)M) also facilitated the uptake of norepinephrine (NE) by rat cerebral cortex slices, but methamphetamine (10-(6)--10(-4)M) exhibited a considerable inhibitory effect.	Norepinephrine	44-58	thyrotropin releasing hormone	Rattus norvegicus	0-3
444301-0	1979	Re-evaluation of the relationship between catechol-O-methyl transferase and the binding of norepinephrine to brown adipocyte membranes.	Norepinephrine	91-105	catechol-O-methyltransferase	Homo sapiens	42-71
444302-0	1979	Control of the brown fat respiratory response to noradrenaline by catechol-O-methyltransferase.	Norepinephrine	49-62	catechol-O-methyltransferase	Homo sapiens	66-94
546488-1	1979	Catechol O-methyltransferase (COMT) obtained from human liver (HL) and human placenta (HP) was found to be much less active than rat liver (RL) COMT when norepinephrine, epinephrine, dopamine, and isoproterenol are used as substrates.	Norepinephrine	154-168	catechol-O-methyltransferase	Homo sapiens	0-28
546488-1	1979	Catechol O-methyltransferase (COMT) obtained from human liver (HL) and human placenta (HP) was found to be much less active than rat liver (RL) COMT when norepinephrine, epinephrine, dopamine, and isoproterenol are used as substrates.	Norepinephrine	154-168	catechol-O-methyltransferase	Homo sapiens	30-34
42366-4	1979	Noradrenaline in the concentration range 2.5--10.0 micrograms/ml decreased the luteinizing-hormone-releasing-hormone (LHRH) sensitivity of the pituitary cells.	Norepinephrine	0-13	gonadotropin releasing hormone 1	Homo sapiens	79-116
42366-4	1979	Noradrenaline in the concentration range 2.5--10.0 micrograms/ml decreased the luteinizing-hormone-releasing-hormone (LHRH) sensitivity of the pituitary cells.	Norepinephrine	0-13	gonadotropin releasing hormone 1	Homo sapiens	118-122
220287-1	1979	C-6 glial tumor cells treated with norepinephrine and sodium azide accumulated cyclic GMP to concentrations approximately 10-fold greater than the sum of the separate responses.	Norepinephrine	35-49	complement C6	Homo sapiens	0-3
717534-1	1978	We have recently shown that insulin attenuates norepinephrine (NE) dose-response curves in both isolated cardiac muscle and intact heart preparations.	Norepinephrine	47-61	insulin	Oryctolagus cuniculus	28-35
214168-1	1978	Norepinephrine stimulates Na, K-ATPase from rat brain homogenates at concentrations of 10(-4)--10(-5) and 10(-7)--10(-8) M. A low concentration maximum is observed after 48 hrs of incubation at -20 degrees C and is not changed by the addition of alpha-tocopherol, glycerol and MAO inhibitor ipraside.	Norepinephrine	0-14	monoamine oxidase A	Rattus norvegicus	277-280
31297-1	1978	Added to a striatal synaptosomal homogenate of rat brain, CDP-choline 10(-4) M inhibits the uptake of norepinephrine (NE), dopamine (DA) and serotonin (5 HT) in a competitive fashion and enhances the uptake of tyrosine and tryptophan; administered to animals, CDP-choline (50 mg/kg/l h/i.v.)	Norepinephrine	102-116	cut-like homeobox 1	Rattus norvegicus	58-61
31297-1	1978	Added to a striatal synaptosomal homogenate of rat brain, CDP-choline 10(-4) M inhibits the uptake of norepinephrine (NE), dopamine (DA) and serotonin (5 HT) in a competitive fashion and enhances the uptake of tyrosine and tryptophan; administered to animals, CDP-choline (50 mg/kg/l h/i.v.)	Norepinephrine	102-116	cut-like homeobox 1	Rattus norvegicus	260-263
100786-2	1978	Norepinephrine in doses of 10(-4)--10(-6) M induced release of thyrotropin releasing factor which increased progressively with time and was temperature and dose dependent.	Norepinephrine	0-14	thyrotropin releasing hormone	Rattus norvegicus	63-91
565244-0	1978	Effect of stress and of phenylethanolamine-N-methyltransferase inhibition on central norepinephrine and epinephrine levels.	Norepinephrine	85-99	phenylethanolamine N-methyltransferase	Homo sapiens	24-62
215928-0	1978	Effect of norepinephrine on renin release and the cyclic AMP content of rat kidney slices: modification by sodium deficiency and alpha-adrenergic blockade.	Norepinephrine	10-24	renin	Rattus norvegicus	28-33
215928-1	1978	The effect of L-norepinephrine (NE) on renin release by slices of kidney cortex from sodium-replete and sodium-deficient rats was studied in vitro.	Norepinephrine	14-30	renin	Rattus norvegicus	39-44
589439-2	1977	These cells were used because, like sympathetic neurons, they synthesize large amounts of noradrenaline in the presence of ascorbate, they respond to nerve growth factor with the production of neurites and they release, store and take up catecholamines.	Norepinephrine	90-103	nerve growth factor	Rattus norvegicus	150-169
589929-12	1977	We conclude that noradrenaline-secreting phaeochromocytoma impairs the response of plasma renin activity in the rat by inhibiting renin release.	Norepinephrine	17-30	renin	Rattus norvegicus	90-95
589929-12	1977	We conclude that noradrenaline-secreting phaeochromocytoma impairs the response of plasma renin activity in the rat by inhibiting renin release.	Norepinephrine	17-30	renin	Rattus norvegicus	130-135
200741-0	1977	[Norepinephrine interference in adrenal hormone balance related to blood calcium effects of PTH (author"s transl)].	Norepinephrine	1-15	LOW QUALITY PROTEIN: parathyroid hormone	Cavia porcellus	92-95
200741-3	1977	Norepinephrine restores the blood calcium effects of PTH in these cases but epinephrine is inactive.	Norepinephrine	0-14	LOW QUALITY PROTEIN: parathyroid hormone	Cavia porcellus	53-56
200741-6	1977	But in this test, norepinephrine reduces the effect of PTH (fig.	Norepinephrine	18-32	LOW QUALITY PROTEIN: parathyroid hormone	Cavia porcellus	55-58
20213-4	1977	While in the hypothyroid animals at 4 degrees C the concentration of adrenal catecholamines was less, the epinephrine to norepinephrine ratio was higher than at 23 degrees C. Very high TH activity with a decline in catecholamine concentration suggests that the capacity of TH had been exceeded.	Norepinephrine	121-135	tyrosine hydroxylase	Rattus norvegicus	185-187
872085-6	1977	Twelve and 18 hr after the injection of vincristine (1000 microgram/kg), the plasma concentration of thyroid-stimulating hormone was reduced, whereas the hypothalamic content of norepinephrine, a neurotransmitter involved in the regulation of thyrotropin-releasing hormone-thyroid-stimulating hormone secretion, remained unchanged.	Norepinephrine	178-192	thyrotropin releasing hormone	Rattus norvegicus	243-272
888400-0	1977	[Glucose-6-phosphate dehydrogenase in rat liver and myocardium following toxic doses of noradrenaline].	Norepinephrine	88-101	glucose-6-phosphate dehydrogenase	Rattus norvegicus	1-34
888400-1	1977	Administration of toxic doses of noradrenaline into rats led to exhaustion of noradrenaline reserves in liver and heart tissues with the simultaneous increase in the activity of glucose-6-phosphate dehydrogenase in the tissues.	Norepinephrine	33-46	glucose-6-phosphate dehydrogenase	Rattus norvegicus	178-211
888400-2	1977	Actinomycin D, administered together with noradrenaline, completely prevented the elevation of the G6PD activity in the tissues studied.	Norepinephrine	42-55	glucose-6-phosphate dehydrogenase	Rattus norvegicus	99-103
14816-1	1977	Plasmin noradrenaline concentration after bicycle exercise (200 W for 2 min), compared with base line concentration, was used as an index of sympathetic responsiveness in patients with essential hypertension.	Norepinephrine	8-21	plasminogen	Homo sapiens	0-7
71087-0	1977	Modifications of arterial pressure and plasma renin: their effects on the norepinephrine content of hypothalamus and medulla oblongata.	Norepinephrine	74-88	renin	Rattus norvegicus	46-51
410749-4	1977	In spite of the equivocal findings in some of the clinical studies, a recent investigation raised the possibility that a transient favorable response to TRH may identify a patient population responsive to maprotilline, or other norepinephrine uptake inhibitors.	Norepinephrine	228-242	thyrotropin releasing hormone	Homo sapiens	153-156
186275-3	1976	The twitch inhibition caused by noradrenaline is abolished by alpha- + beta2-adrenoceptor blockers, but not by either blocker alone.	Norepinephrine	32-45	beta-2 adrenergic receptor	Cavia porcellus	71-89
939004-8	1976	Significant (P less than 0.05) inhibition of renin release was induced by l-epinephrine or l-norepinephrine (10(-5) M).	Norepinephrine	91-107	renin	Rattus norvegicus	45-50
1276880-0	1976	Metabolism of centrally released noradrenaline by extraneuronal monoamine oxidase and catechol-O-methyltransferase.	Norepinephrine	33-46	catechol-O-methyltransferase	Homo sapiens	86-114
6261-6	1976	Three conclusions appear to be justified: (a) noradrenergic axons which innervate the median eminence, arcuate, and ventromedial nuclei course in the ventral norepinephrine bundles; (b) the TH content of noradrenergic neurons in the median eminence, arcuate nucleus, and ventromedial nuclei is quite small; and (c) the majority, if not all, of the endocrine-responsive catecholaminergic neurons in the median eminence are dopaminergic.	Norepinephrine	158-172	tyrosine hydroxylase	Rattus norvegicus	190-192
935219-4	1976	Combined reserpine and ECS have been shown to produce an intermediate level of serotonin and norepinephrine, but seizure threshold data for this group is absent.	Norepinephrine	93-107	epistatic circling SWR/J	Mus musculus	23-26
960237-3	1976	MAO activity with norepinephrine and in an insignificant increase in the activity with the other substrates.	Norepinephrine	18-32	monoamine oxidase A	Rattus norvegicus	0-3
769554-5	1976	On the other hand, after a single intravenous 100 mug dose of LH-RH, a significant rise in plasma norepinephrine, preceding the LH peak, was found in the four patients studied.	Norepinephrine	98-112	gonadotropin releasing hormone 1	Homo sapiens	62-67
769554-6	1976	The determination of norepinephrine at 3 minute intervals beginning one minute after LH-RH injection showed a significant rise in the amine levels ranging from 5 to 10 times in respect to basal values between 1 and 6 minutes after LH-RH stimulation.	Norepinephrine	21-35	gonadotropin releasing hormone 1	Homo sapiens	85-90
769554-6	1976	The determination of norepinephrine at 3 minute intervals beginning one minute after LH-RH injection showed a significant rise in the amine levels ranging from 5 to 10 times in respect to basal values between 1 and 6 minutes after LH-RH stimulation.	Norepinephrine	21-35	gonadotropin releasing hormone 1	Homo sapiens	231-236
971551-9	1976	Release of renin was directly proportional to the number of glomeruli and could be stimulated by isoprenaline, adrenaline and noradrenaline in order of the potency of their action on beta-adrenoreceptors.	Norepinephrine	126-139	renin	Rattus norvegicus	11-16
178388-2	1975	It was shown that 24 hours after int noradrenaline injection which caused exhaustion of endogenous catecholamine supply, the lactate content and the activities of lactic dehydrogenase were increased in the myocardium; the activity of hexokinase and G-6-PDH in rat myocardium and the liver were also increased, whereas the glucokinase activity was decreased.	Norepinephrine	37-50	glucose-6-phosphate dehydrogenase	Rattus norvegicus	249-256
178388-2	1975	It was shown that 24 hours after int noradrenaline injection which caused exhaustion of endogenous catecholamine supply, the lactate content and the activities of lactic dehydrogenase were increased in the myocardium; the activity of hexokinase and G-6-PDH in rat myocardium and the liver were also increased, whereas the glucokinase activity was decreased.	Norepinephrine	37-50	glucokinase	Rattus norvegicus	322-333
1157220-4	1975	Significant dose-related stimulation of renin release was observed with epinephrine and norepinephrine in concentrations from 1.5 times 10(-9) to 1.5 times 10(-7)M and with isoproterenol in concentrations from 2 times 10(-9) to 2 times 10(-7)M. No significant stimulation was seen with 10(-10)M concentrations of the three agents.	Norepinephrine	88-102	renin	Rattus norvegicus	40-45
234274-1	1975	Norepinephrine (NE) elevates levels of both 3",5"-guanosine monophosphate (cyclic GMP) and 3",5"-adenosine monophosphate (cyclic AMP) in incubated slices of mouse cerebellum.	Norepinephrine	0-14	5'-nucleotidase, cytosolic II	Mus musculus	82-85
1169697-0	1975	Diurnal variations in plasma corticosterone and growth hormone as corrlelated with regional variations in norepinephrine, dopamine and serotonin content of rat brain.	Norepinephrine	106-120	gonadotropin releasing hormone receptor	Rattus norvegicus	48-62
4215671-0	1974	Enhancement of cerebral noradrenaline turnover by thyrotropin-releasing hormone: evidence by fluorescence histochemistry.	Norepinephrine	24-37	thyrotropin releasing hormone	Homo sapiens	50-79
4436812-5	1974	Nicotine, noradrenaline (NA) and hypertonic saline caused release of ADH, whereas microinjections of isotonic saline did not affect the blood level of the hormone.3.	Norepinephrine	10-23	alcohol dehydrogenase 1C (class I), gamma polypeptide	Rattus norvegicus	69-72
4700605-3	1973	In the second and third weeks after the trauma, NGF-treated rats ate more food, regained body weight more rapidly, and fed more vigorously in response to intraventricular administration of norepinephrine than untreated controls.	Norepinephrine	189-203	nerve growth factor	Rattus norvegicus	48-51
4700605-5	1973	NGF may facilitate behavioral recovery by promoting the development of supersensitivity to norepinephrine and possibly also by stimulating the growth of regenerating noradrenergic neurons in the brain.	Norepinephrine	91-105	nerve growth factor	Rattus norvegicus	0-3
4775864-2	1973	The effects of chlorpromazine, haloperidol, and thioridazine on brain noradrenaline content elevated by previous administration of MAO inhibitors.	Norepinephrine	70-83	monoamine oxidase A	Rattus norvegicus	131-134
24179066-3	1971	This paper reviews evidence indicating that menstrual cycle psychopathology may be mediated by the effects of estrogen, progesterone, and possibly the renin-angiotensin-aldosterone system on the brain monoamines, norepinephrine, dopamine, and serotonin.	Norepinephrine	213-227	renin	Rattus norvegicus	151-156
6040406-0	1967	Inhibition of histidine decarboxylase activity in vitro by norepinephrine and related compounds.	Norepinephrine	59-73	histidine decarboxylase	Homo sapiens	14-37
33896555-4	2021	Starting from norepinephrine monomer, a highly selective and sensitive molecularly imprinted polymer (MIP) was developed and optimized for optical real-time and label-free SPR biosensing.	Norepinephrine	14-28	sepiapterin reductase	Homo sapiens	172-175
34052431-8	2021	In situ inhibition of COX-2, TXA2 synthase, or TP receptor reduced the Emax to noradrenaline in MRA of ouabain to vehicle levels.	Norepinephrine	79-92	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	22-27
32717063-8	2021	Norepinephrine-angiotensin II treatment of cultured human cardiomyocytes induced secretion of NT pro-BNP and recapitulated the upregulation of these genes, indicating conservation of the upregulation in failing cardiomyocytes.	Norepinephrine	0-14	natriuretic peptide B	Homo sapiens	101-104
33904806-8	2021	RESULTS: Incubation of blood with epinephrine and norepinephrine significantly increased LPS-stimulated production of IL-10, compared with the control.	Norepinephrine	50-64	interleukin 10	Canis lupus familiaris	118-123
33904806-12	2021	CONCLUSIONS AND CLINICAL RELEVANCE: Epinephrine and norepinephrine, but not dobutamine, had immunomodulatory effects on LPS-stimulated TNF-alpha and IL-10 production in blood from healthy dogs in this in vitro model of sepsis.	Norepinephrine	52-66	interleukin 10	Canis lupus familiaris	149-154
33580322-2	2021	Hindbrain noradrenergic neurons innervate the VMN, where norepinephrine regulates nNOS and GAD expression.	Norepinephrine	57-71	nitric oxide synthase 1	Homo sapiens	82-86
33093660-3	2021	To understand the structural basis for this physiologically important selectivity, we solved the crystal structures of the human beta1AR bound to an antagonist carazolol and different agonists including norepinephrine, epinephrine and BI-167107.	Norepinephrine	203-217	adrenoceptor beta 1	Homo sapiens	129-136
33737848-10	2021	Results: We found 24-hour urinary norepinephrine levels were associated with systolic and diastolic BP (SBP, beta=0.157, p=0.082; DBP, beta=0.212, p=0.023) and mean arterial pressure (MAP, beta=0.198, p=0.032) after adjusting for confounders.	Norepinephrine	34-48	selenium binding protein 1	Homo sapiens	104-107
33737848-12	2021	After adjusting for confounders, increased 24-hour urinary norepinephrine levels were significantly associated with elevated SBP (beta=0.454, p=0.012), DBP (beta=0.399, p=0.041), and MAP (beta=0.432, p=0.023) in normal weight, but not in overweight/obese patients (all p>0.2).	Norepinephrine	59-73	selenium binding protein 1	Homo sapiens	125-128
33665818-0	2021	Downregulation of connexin43 potentiates noradrenaline-induced expression of brain-derived neurotrophic factor in primary cultured cortical astrocytes.	Norepinephrine	41-54	gap junction protein alpha 1	Homo sapiens	18-28
33481407-17	2021	Our studies suggest that both beta1- and beta2-adrenergic receptor mediate the stabilizing effects of epinephrine and norepinephrine on the endothelial barrier.	Norepinephrine	118-132	adrenoceptor beta 1	Homo sapiens	30-66
33434145-7	2021	Exposure of excess norepinephrine significantly restricted the induced expression of decidualized markers Dtprp, BMP2, WNT4, and Hand2 in mice.	Norepinephrine	19-33	prolactin family 8, subfamily a, member 2	Mus musculus	106-111
33434145-7	2021	Exposure of excess norepinephrine significantly restricted the induced expression of decidualized markers Dtprp, BMP2, WNT4, and Hand2 in mice.	Norepinephrine	19-33	wingless-type MMTV integration site family, member 4	Mus musculus	119-123
33434145-8	2021	In vitro, 10 microM norepinephrine markedly downregulated the expressions of prolactin, IGFBP1, and PLZF, which are the specifical markers of decidual stromal cells during decidualization.	Norepinephrine	20-34	insulin-like growth factor binding protein 1	Mus musculus	88-94
33716987-5	2021	The administration of estradiol valerate (a polycystic ovary [PCO] phenotype model) increased norepinephrine (NE) (through an NGF-dependent mechanism) and acetylcholine (ACh) levels.	Norepinephrine	94-108	nerve growth factor	Rattus norvegicus	126-129
33100271-6	2021	The beta1AR-mediated dilation elicited by the endogenous adrenergic agonist norepinephrine (NE) was reversed to a sustained constriction by MET.	Norepinephrine	76-90	MET proto-oncogene, receptor tyrosine kinase	Rattus norvegicus	140-143
33280472-7	2021	The beta2-AR protein levels were obviously increased (P < 0.05) due to the markedly elevated norepinephrine (NE) concentration (P < 0.05).	Norepinephrine	93-107	adenosine A2a receptor	Mus musculus	4-12
33207866-0	2020	Theoretical Investigation of the Inhibitory Mechanism of Norepinephrine on hIAPP Amyloid Aggregation and the Destabilization of Protofibrils.	Norepinephrine	57-71	islet amyloid polypeptide	Homo sapiens	75-80
33207866-3	2020	Hence, we study the role of a catecholamine, norepinephrine, on the amyloid aggregation of hIAPP, which has previously displayed inhibitory effect on amyloid-beta aggregation.	Norepinephrine	45-59	islet amyloid polypeptide	Homo sapiens	91-96
33207866-4	2020	Via all-atom molecular dynamics simulations, we observe that norepinephrine can not only inhibit the aggregation of hIAPP but also partially disassemble the preformed fibrils.	Norepinephrine	61-75	islet amyloid polypeptide	Homo sapiens	116-121
33207866-6	2020	We observe that the conformational preference of hIAPP changes from a beta-sheet conformation to a disordered state when norepinephrine is added to the peptides.	Norepinephrine	121-135	islet amyloid polypeptide	Homo sapiens	49-54
33207866-8	2020	In-depth investigation reveals that the beta-sheets formed between Leu12-His18 and Leu27-Gly33 enhance the peptide-peptide interactions that are broken by norepinephrine, which itself interacts with the peptides via hydrogen bonding, hydrophobic, and aromatic stacking interactions, preferentially with the C-terminal residues of hIAPP.	Norepinephrine	155-169	islet amyloid polypeptide	Homo sapiens	330-335
33207866-9	2020	The molecular mechanism action of norepinephrine on hIAPP aggregation can provide useful insight for the drug design against T2D.	Norepinephrine	34-48	islet amyloid polypeptide	Homo sapiens	52-57
33103204-11	2020	Conversely, noradrenaline was associated with a lower likelihood of arrhythmias and most importantly decreased mortality in CS.	Norepinephrine	12-25	citrate synthase	Homo sapiens	124-126
33103204-13	2020	Our literature review suggests that treatment combination of the inotrope levosimendan with the vasopressor noradrenaline may be the most effective management option in CS.	Norepinephrine	108-121	citrate synthase	Homo sapiens	169-171
32603826-3	2020	Studies suggest that TRPV1 expression may be regulated by norepinephrine (NE)-activated alpha2-adrenergic receptors (alpha2-ADR) in the dorsal root ganglia.	Norepinephrine	58-72	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	21-26
32750368-4	2020	Noradrenaline and methoxamine increased alpha1A-adrenoceptor interaction with Rab5 and Rab7 but did not modify it with Rab9.	Norepinephrine	0-13	adrenoceptor alpha 1A	Homo sapiens	40-60
32750368-4	2020	Noradrenaline and methoxamine increased alpha1A-adrenoceptor interaction with Rab5 and Rab7 but did not modify it with Rab9.	Norepinephrine	0-13	RAB7B, member RAS oncogene family	Homo sapiens	87-91
33000941-3	2020	Norepinephrine is very similar in structure and chemical properties to the other two catecholamine neurotransmitters, epinephrine (EP) and dopamine (DA).	Norepinephrine	0-14	epiregulin	Homo sapiens	131-133
32702980-11	2020	Structural analysis revealed that inhibitor 3 binds to hPNMT by filling the catalytic binding pockets for the cofactor (SAM) and the substrate (norepinephrine) binding sites.	Norepinephrine	144-158	phenylethanolamine N-methyltransferase	Homo sapiens	55-60
32648904-1	2020	Sympathetically mediated contractions of smooth muscle cells in vasa deferentia are mediated by neuronally released adenosine 5"-triphosphate (ATP) and noradrenaline, which stimulate P2X1-purinoreceptors and alpha1A-adrenoceptors respectively.	Norepinephrine	152-165	purinergic receptor P2X 1	Rattus norvegicus	183-187
32473155-12	2020	Ectopic expression of GATA3 enhanced the expression of UCP-1 and thermogenic genes upon treatment with norepinephrine whereas GATA3 knockdown had the opposite effect.	Norepinephrine	103-117	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	55-60
32643759-11	2020	Altogether, these results suggest that alpha2A-AR deficiency ameliorates lung injury by increasing norepinephrine concentrations in lung tissues and inhibiting the activation of alveolar macrophages.	Norepinephrine	99-113	adenosine A2a receptor	Mus musculus	39-49
32730300-9	2020	At the cellular level, cultured cells from brown adipose tissue (BAT) of Pdgfralpha-Cre Ahrfl/fl mice were more responsive than cells from controls to transcriptional activation of the thermogenic uncoupling protein 1 (Ucp1) gene by norepinephrine, suggesting an ability to burn more energy under certain conditions.	Norepinephrine	233-247	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	197-217
32730300-9	2020	At the cellular level, cultured cells from brown adipose tissue (BAT) of Pdgfralpha-Cre Ahrfl/fl mice were more responsive than cells from controls to transcriptional activation of the thermogenic uncoupling protein 1 (Ucp1) gene by norepinephrine, suggesting an ability to burn more energy under certain conditions.	Norepinephrine	233-247	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	219-223
32426489-6	2020	We further show that the sympathetic neurotransmitter norepinephrine, or specific agonists of the beta2-adrenergic receptor, can inhibit the LPS- or IL-33-elicited immune response in a cell-intrinsic manner.	Norepinephrine	54-68	interleukin 33	Homo sapiens	149-154
31964979-9	2020	Norepinephrine requirements during human liver transplantation correlated significantly with DAO concentrations in the anhepatic phase (r = 0.58, p = 0.011) and after reperfusion (r = 0.56; p = 0.022).	Norepinephrine	0-14	amine oxidase copper containing 1	Homo sapiens	93-96
31964979-11	2020	Diamine oxidase correlates with intraoperative norepinephrine requirements in patients undergoing OLT.	Norepinephrine	47-61	amine oxidase copper containing 1	Homo sapiens	0-15
31941827-0	2020	beta-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3beta/tau cascade.	Norepinephrine	23-37	glycogen synthase kinase 3 beta	Homo sapiens	75-83
31941827-3	2020	Our results show that Abeta oligomers bind to an allosteric site on alpha2A adrenergic receptor (alpha2AAR) to redirect norepinephrine-elicited signaling to glycogen synthase kinase 3beta (GSK3beta) activation and tau hyperphosphorylation.	Norepinephrine	120-134	glycogen synthase kinase 3 beta	Homo sapiens	157-187
31941827-3	2020	Our results show that Abeta oligomers bind to an allosteric site on alpha2A adrenergic receptor (alpha2AAR) to redirect norepinephrine-elicited signaling to glycogen synthase kinase 3beta (GSK3beta) activation and tau hyperphosphorylation.	Norepinephrine	120-134	glycogen synthase kinase 3 beta	Homo sapiens	189-197
31941827-4	2020	This norepinephrine-dependent mechanism sensitizes pathological GSK3beta/tau activation in response to nanomolar accumulations of extracellular Abeta, which is 50- to 100-fold lower than the amount required to activate GSK3beta by Abeta alone.	Norepinephrine	5-19	glycogen synthase kinase 3 beta	Homo sapiens	64-72
31941827-4	2020	This norepinephrine-dependent mechanism sensitizes pathological GSK3beta/tau activation in response to nanomolar accumulations of extracellular Abeta, which is 50- to 100-fold lower than the amount required to activate GSK3beta by Abeta alone.	Norepinephrine	5-19	glycogen synthase kinase 3 beta	Homo sapiens	219-227
31813250-9	2020	Furthermore, mice deficient in Paneth cells (SOX9 Villin Cre mice) have reduced plasma norepinephrine levels after ischemic AKI.	Norepinephrine	87-101	SRY (sex determining region Y)-box 9	Mus musculus	45-49
31848393-6	2019	Paradoxically, these Fgf21-/- CKD mice escaped several complications observed in wild-type mice, including augmentation of blood pressure elevating response and activation of the sympathetic nervous system during physical activity and increase in serum noradrenalin and corticosterone levels.	Norepinephrine	253-265	fibroblast growth factor 21	Mus musculus	21-26
31608673-0	2019	Sympathetic regulation of NCC in norepinephrine-evoked salt-sensitive hypertension in Sprague-Dawley rats.	Norepinephrine	33-47	solute carrier family 12 member 3	Rattus norvegicus	26-29
31608673-2	2019	In salt-resistant animal models, exogenous norepinephrine (NE) infusion promotes salt-sensitive hypertension and prevents dietary Na+-evoked suppression of the Na+-Cl- cotransporter (NCC).	Norepinephrine	43-57	solute carrier family 12 member 3	Rattus norvegicus	160-181
31608673-2	2019	In salt-resistant animal models, exogenous norepinephrine (NE) infusion promotes salt-sensitive hypertension and prevents dietary Na+-evoked suppression of the Na+-Cl- cotransporter (NCC).	Norepinephrine	43-57	solute carrier family 12 member 3	Rattus norvegicus	183-186
31494174-3	2019	Previous studies revealed that daily light onset activates norepinephrine (NE)-induced BM CXCL12 downregulation, followed by CXCR4+ HSPC release to the circulation.	Norepinephrine	59-73	C-X-C motif chemokine ligand 12	Homo sapiens	90-96
31352713-8	2019	The effect of MPH, cumulating dopamine and noradrenaline in the synaptic gap could be associated with the acceleration of puberty with the excitatory effect of dopamines gonadotropin-releasing hormone (GnRH) release, excitatory effect of noradrenalines GnRH release and the disappearance of GnRH receptor expression suppressor effect on prolactin disinhibitory effect.	Norepinephrine	43-56	gonadotropin releasing hormone 1	Homo sapiens	202-206
31352713-8	2019	The effect of MPH, cumulating dopamine and noradrenaline in the synaptic gap could be associated with the acceleration of puberty with the excitatory effect of dopamines gonadotropin-releasing hormone (GnRH) release, excitatory effect of noradrenalines GnRH release and the disappearance of GnRH receptor expression suppressor effect on prolactin disinhibitory effect.	Norepinephrine	43-56	gonadotropin releasing hormone 1	Homo sapiens	253-257
31352713-8	2019	The effect of MPH, cumulating dopamine and noradrenaline in the synaptic gap could be associated with the acceleration of puberty with the excitatory effect of dopamines gonadotropin-releasing hormone (GnRH) release, excitatory effect of noradrenalines GnRH release and the disappearance of GnRH receptor expression suppressor effect on prolactin disinhibitory effect.	Norepinephrine	43-56	gonadotropin releasing hormone receptor	Homo sapiens	291-304
31413360-5	2019	Like AICAR, an activator of AMPK, catecholamines (norepinephrine and isoproterenol) and SFAs (palmitate and stearate) significantly increased FGF21 production and release by cardiac myocytes via AMPK activation.	Norepinephrine	50-64	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	5-10
31413360-5	2019	Like AICAR, an activator of AMPK, catecholamines (norepinephrine and isoproterenol) and SFAs (palmitate and stearate) significantly increased FGF21 production and release by cardiac myocytes via AMPK activation.	Norepinephrine	50-64	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	195-199
31526440-5	2019	Moreover, induced noradrenaline concentration, DBH activity, and inhibited NET were blunted by TG101348 (JAK2 inhibitor).	Norepinephrine	18-31	Janus kinase 2	Homo sapiens	105-109
31526440-6	2019	JAK2 silencing also abolished the effects of leptin on noradrenaline metabolism.	Norepinephrine	55-68	Janus kinase 2	Homo sapiens	0-4
30933374-15	2019	Gallbladder emptying and the FGF19 response were respectively disturbed or absent in patients receiving norepinephrine.	Norepinephrine	104-118	fibroblast growth factor 19	Homo sapiens	29-34
31151797-10	2019	In wildtype mice, chronic thyroxine treatment induced a large relative increase in the total amounts of UCP1 in the brown adipose tissue (practically no UCP1 in brite/beige adipose tissue), corresponding to an enhanced thermogenic response to norepinephrine injection.	Norepinephrine	243-257	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	104-108
31048375-8	2019	Treatment of brown adipocytes with MetAP2 inhibitors enhances norepinephrine-induced lipolysis and energy expenditure, and prolongs the activity of norepinephrine to increase ucp1 gene expression and energy expenditure in norepinephrine-desensitized brown adipocytes.	Norepinephrine	148-162	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	175-179
31048375-8	2019	Treatment of brown adipocytes with MetAP2 inhibitors enhances norepinephrine-induced lipolysis and energy expenditure, and prolongs the activity of norepinephrine to increase ucp1 gene expression and energy expenditure in norepinephrine-desensitized brown adipocytes.	Norepinephrine	148-162	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	175-179
31367831-2	2019	In this study, we used a rat model that allowed blocking the synthesis of noradrenalin in the brain and evaluated gene expression and protein levels of noradrenaline key synthesis enzymes such as tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) in peripheral noradrenaline-producing organs.	Norepinephrine	152-165	tyrosine hydroxylase	Rattus norvegicus	196-216
31367831-2	2019	In this study, we used a rat model that allowed blocking the synthesis of noradrenalin in the brain and evaluated gene expression and protein levels of noradrenaline key synthesis enzymes such as tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) in peripheral noradrenaline-producing organs.	Norepinephrine	152-165	tyrosine hydroxylase	Rattus norvegicus	218-220
31367831-2	2019	In this study, we used a rat model that allowed blocking the synthesis of noradrenalin in the brain and evaluated gene expression and protein levels of noradrenaline key synthesis enzymes such as tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) in peripheral noradrenaline-producing organs.	Norepinephrine	272-285	tyrosine hydroxylase	Rattus norvegicus	196-216
30711897-12	2019	Overall, data reveal that stress exposure in male rats affects the regulation of brain IL-1beta by the norepinephrine-beta-AR pathway, while stress had no effect in the regulation of brain IL-1beta in female rats.	Norepinephrine	103-117	ferredoxin reductase	Rattus norvegicus	123-125
30787395-5	2019	Mechanistic analysis showed that exposure to photopic light down-regulates the expression of alpha1A-adrenoceptor (alpha1AAR) due to high levels of norepinephrine and epinephrine, subsequently suppressing inflammation.	Norepinephrine	148-162	adrenoceptor alpha 1A	Homo sapiens	93-113
30787395-5	2019	Mechanistic analysis showed that exposure to photopic light down-regulates the expression of alpha1A-adrenoceptor (alpha1AAR) due to high levels of norepinephrine and epinephrine, subsequently suppressing inflammation.	Norepinephrine	148-162	adrenoceptor alpha 1A	Homo sapiens	115-124
30571558-3	2019	Application of norepinephrine increased the basolateral 40 pS K+ channel (Kir4.1/Kir5.1 heterotetramer) in the DCT.	Norepinephrine	15-29	potassium inwardly-rectifying channel, subfamily J, member 10	Mus musculus	74-80
30571558-8	2019	Renal clearance study demonstrated that norepinephrine perfusion augmented thiazide-induced urinary Na+ excretion only in wild-type but not in kidney-specific Kir4.1 knockout mice, suggesting that Kir4.1 is required for mediating the effect of norepinephrine on NCC.	Norepinephrine	40-54	potassium inwardly-rectifying channel, subfamily J, member 10	Mus musculus	197-203
30571558-8	2019	Renal clearance study demonstrated that norepinephrine perfusion augmented thiazide-induced urinary Na+ excretion only in wild-type but not in kidney-specific Kir4.1 knockout mice, suggesting that Kir4.1 is required for mediating the effect of norepinephrine on NCC.	Norepinephrine	244-258	potassium inwardly-rectifying channel, subfamily J, member 10	Mus musculus	197-203
30571558-10	2019	We conclude that the stimulation of beta-adrenergic receptor activates the basolateral Kir4.1 in the DCT and that the activation of Kir4.1 is required for norepinephrine-induced stimulation of NCC.	Norepinephrine	155-169	potassium inwardly-rectifying channel, subfamily J, member 10	Mus musculus	132-138
30376995-0	2018	Oxidant-induced increase in norepinephrine secretion from PC12 cells is dependent on TRPM8 channel-mediated intracellular calcium elevation.	Norepinephrine	28-42	transient receptor potential cation channel, subfamily M, member 8	Rattus norvegicus	85-90
30240563-1	2018	Methamphetamine, a human vesicular monoamine transporter 2 (VMAT2) substrate, releases dopamine, serotonin, and norepinephrine from vesicles into the cytosol of presynaptic neurons and induces reverse transport by the monoamine transporters to increase extracellular neurotransmitters.	Norepinephrine	112-126	solute carrier family 18 member A2	Homo sapiens	25-58
30240563-1	2018	Methamphetamine, a human vesicular monoamine transporter 2 (VMAT2) substrate, releases dopamine, serotonin, and norepinephrine from vesicles into the cytosol of presynaptic neurons and induces reverse transport by the monoamine transporters to increase extracellular neurotransmitters.	Norepinephrine	112-126	solute carrier family 18 member A2	Homo sapiens	60-65
30277480-6	2018	We also showed that alpha1A-adrenoceptor expression is upregulated under the action of noradrenaline.	Norepinephrine	87-100	adrenoceptor alpha 1A	Homo sapiens	20-40
29915137-5	2018	These neurons (GABAVLPO HDC or GABAVLPO orexin neurons) were both potently inhibited by noradrenaline and serotonin, showing typical electrophysiological characteristics of sleep-promoting neurons in the VLPO.	Norepinephrine	88-101	histidine decarboxylase	Homo sapiens	24-27
29915137-5	2018	These neurons (GABAVLPO HDC or GABAVLPO orexin neurons) were both potently inhibited by noradrenaline and serotonin, showing typical electrophysiological characteristics of sleep-promoting neurons in the VLPO.	Norepinephrine	88-101	hypocretin neuropeptide precursor	Homo sapiens	40-46
29915137-7	2018	Electrophysiological experiments found that GABAergic neurons in the VLPO (GABAVLPO neurons) that make direct input to orexin or histaminergic neurons are potently inhibited by noradrenaline and serotonin, suggesting that these monoamines disinhibit histamine and orexin neurons.	Norepinephrine	177-190	hypocretin neuropeptide precursor	Homo sapiens	119-125
29915137-7	2018	Electrophysiological experiments found that GABAergic neurons in the VLPO (GABAVLPO neurons) that make direct input to orexin or histaminergic neurons are potently inhibited by noradrenaline and serotonin, suggesting that these monoamines disinhibit histamine and orexin neurons.	Norepinephrine	177-190	hypocretin neuropeptide precursor	Homo sapiens	264-270
29991229-9	2018	Conclusions: The present study suggests that phenylephrine activates the alpha-1A adrenergic receptor (AR) of the sensory nerve, and then activates capsaicin-sensitive sensory nerves to release an unknown substance that facilitates the release of norepinephrine from adrenergic nerves.	Norepinephrine	247-261	adrenergic receptor, alpha 1d	Mus musculus	73-101
29932493-6	2018	In a separate experiment, we found that the application of norepinephrine or acetylcholine decreases the expression of cyclin D1, a gene necessary for cell cycle progression, in intestinal epithelial organoids compared with controls (P &lt; 0.05).	Norepinephrine	59-73	cyclin D1	Homo sapiens	119-128
29388468-10	2018	CH enhances H2O2- and ATP-induced increase in [Ca2+]i in PASMCs and PLC-dependent, norepinephrine-evoked pulmonary vasoconstriction.	Norepinephrine	83-97	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	68-71
29524394-2	2018	The current study aimed to clarify the effects of single nucleotide polymorphisms (SNPs) of human SULT1A3 and SULT1A4 genes on the enzymatic characteristics of the sulfation of dopamine, epinephrine, norepinephrine and serotonin by SULT1A3 allozymes.	Norepinephrine	200-214	sulfotransferase family 1A member 4	Homo sapiens	110-117
29477299-1	2018	Activation of serotonin 5-HT3 receptor (5HT3R) in the locus coeruleus (LC), the principal somatodendritic noradrenergic area, decreases LC firing activity and noradrenaline (NA) release in prefrontal cortex (PFC).	Norepinephrine	159-172	5-hydroxytryptamine (serotonin) receptor 3A	Mus musculus	24-38
29477299-1	2018	Activation of serotonin 5-HT3 receptor (5HT3R) in the locus coeruleus (LC), the principal somatodendritic noradrenergic area, decreases LC firing activity and noradrenaline (NA) release in prefrontal cortex (PFC).	Norepinephrine	159-172	5-hydroxytryptamine (serotonin) receptor 3A	Mus musculus	40-45
29343526-11	2018	The concentration of norepinephrine and normetanephrine was decreased in whole-brain homogenates of the CYB561(-/-) mice compared with wild-type mice (P&lt;0.01), and the concentration of normetanephrine and metanephrine was decreased in adrenal glands (P&lt;0.01), recapitulating the clinical phenotype.	Norepinephrine	21-35	cytochrome b-561	Mus musculus	104-110
29593559-8	2018	Ghrelin partially attenuated the CPB-induced elevation of epinephrine and to a lesser extent norepinephrine when compared to the CPB saline group, while dopamine levels were completely suppressed.	Norepinephrine	93-107	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
29306052-8	2018	Interestingly, rats treated with sAbeta showed long-term memory deficits, as confirmed by a significant reduction of discrimination index in the novel object recognition test, along with reduced brain-derived neurotrophic factor expression and increased noradrenaline levels in the Hipp.	Norepinephrine	254-267	SH3-domain binding protein 5	Rattus norvegicus	33-39
29229557-9	2018	This study provides valuable anatomical information about the alpha1bAR and its relationship to the D1R and the regulation of DA and norepinephrine (NE) neurotransmission in the brain which have been examined previously.	Norepinephrine	133-147	adrenoceptor alpha 1B	Rattus norvegicus	62-71
29304162-10	2018	These results suggest that noradrenaline directly acts on dorsal root ganglion neurons to inhibit the activity of TRPV1 depending on the activation of alpha2-adrenoceptors followed by the inhibition of the adenylate cyclase/cAMP/protein kinase A pathway.	Norepinephrine	27-40	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	114-119
29172729-8	2018	Furthermore, BMI, noradrenaline and LnTP were independent determinants of Ln(HOMA-IR) in PIH patients by multiple regression analysis.	Norepinephrine	18-31	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	89-92
28293733-1	2018	Type A monoamine oxidase (MAOA) catabolizes monoamine transmitters, serotonin, norepinephrine and dopamine, and plays a major role in the onset, progression and therapy of neuropsychiatric disorders.	Norepinephrine	79-93	monoamine oxidase A	Homo sapiens	7-24
28293733-1	2018	Type A monoamine oxidase (MAOA) catabolizes monoamine transmitters, serotonin, norepinephrine and dopamine, and plays a major role in the onset, progression and therapy of neuropsychiatric disorders.	Norepinephrine	79-93	monoamine oxidase A	Homo sapiens	26-30
28675448-9	2017	Interestingly, the mPGES-1 inhibitor significantly reduced (30-40%) noradrenaline-induced contractions in both vessels.	Norepinephrine	68-81	prostaglandin E synthase	Mus musculus	19-26
28804807-7	2017	RESULTS: CRH administration induced pronounced increases in cortisol and noradrenaline plasma concentrations, heart rate, and anxiety levels.	Norepinephrine	73-86	corticotropin releasing hormone	Homo sapiens	9-12
28819022-6	2017	These data highlight the potential of adrenergic stress and norepinephrine-driven beta-AR signaling to regulate the immune status of the tumor microenvironment and support the strategic use of clinically available beta-blockers in patients to improve responses to immunotherapy.	Norepinephrine	60-74	adrenergic receptor, beta 2	Mus musculus	82-89
28953873-6	2017	Deletion of NLRP3 in ageing restored catecholamine-induced lipolysis by downregulating growth differentiation factor-3 (GDF3) and monoamine oxidase A (MAOA) that is known to degrade noradrenaline.	Norepinephrine	182-195	NLR family, pyrin domain containing 3	Mus musculus	12-17
28392265-2	2017	Cocaine-primed reinstatement can also be attenuated by systemic administration of dopamine beta-hydroxylase (DBH) inhibitors, which prevent norepinephrine (NE) synthesis, or by alpha1-adrenergic receptor (alpha1AR) antagonists, indicating functional modulation by the noradrenergic system.	Norepinephrine	140-154	dopamine beta-hydroxylase	Rattus norvegicus	82-107
28392265-2	2017	Cocaine-primed reinstatement can also be attenuated by systemic administration of dopamine beta-hydroxylase (DBH) inhibitors, which prevent norepinephrine (NE) synthesis, or by alpha1-adrenergic receptor (alpha1AR) antagonists, indicating functional modulation by the noradrenergic system.	Norepinephrine	140-154	dopamine beta-hydroxylase	Rattus norvegicus	109-112
27815561-2	2017	The placental norepinephrine transporter (NET) clears norepinephrine (NE) from both maternal circulation and the fetus during gestation.	Norepinephrine	14-28	solute carrier family 6 member 2	Rattus norvegicus	42-45
28294055-6	2017	Selective inhibition of MAO-A results in the elevated level of serotonin and noradrenaline.	Norepinephrine	77-90	monoamine oxidase A	Homo sapiens	24-29
27825984-6	2017	Inhibition of PI3Kgamma lipid kinase activity by protein kinase A was disclosed as mechanism causing suppression of microglial migration by noradrenaline.	Norepinephrine	140-153	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	14-23
27681312-5	2016	Moreover, FoxO1 KODAT mice exhibit an increased sucrose preference in concomitance with higher dopamine and norepinephrine levels.	Norepinephrine	108-122	forkhead box O1	Mus musculus	10-15
27316550-3	2016	We hypothesized that ERbeta is critical for hypoglycemia-associated patterns of LH secretion and norepinephrine (NE) activity in key reproduction-relevant forebrain structures.	Norepinephrine	97-111	estrogen receptor 2	Rattus norvegicus	21-27
26227907-1	2016	Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the metabolism of several biological amines such as dopamine, norepinephrine, and serotonin, which are important neurochemicals in the pathogenesis of major psychiatric illnesses.	Norepinephrine	127-141	monoamine oxidase A	Homo sapiens	0-19
26227907-1	2016	Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the metabolism of several biological amines such as dopamine, norepinephrine, and serotonin, which are important neurochemicals in the pathogenesis of major psychiatric illnesses.	Norepinephrine	127-141	monoamine oxidase A	Homo sapiens	21-25
27254000-5	2016	Adrenal catecholamine contents, cellular ultrastructure, and expression of phenylethanolamine N-methyltransferase, which converts norepinephrine to epinephrine, were also determined in wt and mutant rats.	Norepinephrine	130-144	phenylethanolamine-N-methyltransferase	Rattus norvegicus	75-113
27448273-0	2016	Differential Activation in Amygdala and Plasma Noradrenaline during Colorectal Distention by Administration of Corticotropin-Releasing Hormone between Healthy Individuals and Patients with Irritable Bowel Syndrome.	Norepinephrine	47-60	corticotropin releasing hormone	Homo sapiens	111-142
27448273-10	2016	Plasma noradrenaline at baseline significantly increased after CRH injection compared to before injection in IBS.	Norepinephrine	7-20	corticotropin releasing hormone	Homo sapiens	63-66
26843180-3	2016	In fact, previous studies have suggested that norepinephrine can functionally interact with D4R.	Norepinephrine	46-60	dopamine receptor D4	Homo sapiens	92-95
26843180-5	2016	By using radioligand binding and bioluminescent resonance energy transfer (BRET) assays in transfected cells, the present study attempted a careful comparison between dopamine and norepinephrine in their possible activation of all D2-like receptors, including the two D2R isoforms and the most common D4R polymorphic variants.	Norepinephrine	180-194	dopamine receptor D4	Homo sapiens	301-304
26843180-7	2016	Norepinephrine acted as a potent agonist for all D2-like receptor subtypes, with the general rank order of potency of D3R &gt; D4R &gt;= D2SR &gt;= D2L.	Norepinephrine	0-14	dopamine receptor D4	Homo sapiens	127-130
26843180-9	2016	The most striking differences were observed with Galphai2, where the rank order of potencies for both dopamine and norepinephrine were D4R &gt; D2SR = D2LR &gt;&gt; D3R.	Norepinephrine	115-129	dopamine receptor D4	Homo sapiens	135-138
26724392-0	2016	Noradrenaline increases intracellular glutathione in human astrocytoma U-251 MG cells by inducing glutamate-cysteine ligase protein via beta3-adrenoceptor stimulation.	Norepinephrine	0-13	adrenoceptor beta 3	Homo sapiens	136-154
26724392-9	2016	These results thus suggest that noradrenaline increased the GSH concentration in astrocytes by inducing GCLc protein in them via beta3-adrenoceptor stimulation.	Norepinephrine	32-45	adrenoceptor beta 3	Homo sapiens	129-147
26838732-3	2016	The present study aimed to determine the effects of beta3-AR on the promotion of myocardial apoptosis and on norepinephrine (NE) injury.	Norepinephrine	109-123	adrenoceptor beta 3	Homo sapiens	52-60
25482049-3	2016	Recent studies show an important role of prefrontal cortical iPLA2 in hippocampo-prefrontal cortical LTP and antidepressant-like effect of the norepinephrine reuptake inhibitor (NRI) antidepressant, maprotiline.	Norepinephrine	143-157	patatin like phospholipase domain containing 2	Homo sapiens	61-66
25482049-8	2016	Together, results indicate that stimulation of adrenoreceptors causes increased iPLA2 expression via MAP kinase/ERK 1/2 and SREBP, and suggest a possible mechanism for effect of CNS noradrenaline on neural plasticity and crosstalk between sterol and glycerophospholipid mediators, that may play a role in physiological or pathophysiological processes in the brain and other organs.	Norepinephrine	182-195	patatin like phospholipase domain containing 2	Homo sapiens	80-85
26677330-11	2015	CONCLUSION: These results demonstrate that serum levels of interleukin-6, interleukin-8, and macrophage inflammatory protein-1beta as potential blood biomarkers could be utilized to identify the responsiveness of patients to serotonin and norepinephrine reuptake inhibitor like milnacipran, or to identify those patients who may experience AEs strong enough to warrant discontinuation of treatment.	Norepinephrine	239-253	C-C motif chemokine ligand 4 like 2	Homo sapiens	93-130
26144997-0	2015	Noradrenaline modulates the presence of gonadotropin-releasing hormone in ovary.	Norepinephrine	0-13	gonadotropin releasing hormone 1	Rattus norvegicus	40-70
26412054-2	2015	The drug has a high affinity for serotonin 5-HT1A and 5-HT2A receptors (5-HT1A agonist/5-HT2A antagonist) and is believed to treat HSDD by increasing levels of dopamine and noradrenaline and lowering levels of serotonin in the brain.	Norepinephrine	173-186	5-hydroxytryptamine receptor 1A	Homo sapiens	43-49
26412054-2	2015	The drug has a high affinity for serotonin 5-HT1A and 5-HT2A receptors (5-HT1A agonist/5-HT2A antagonist) and is believed to treat HSDD by increasing levels of dopamine and noradrenaline and lowering levels of serotonin in the brain.	Norepinephrine	173-186	5-hydroxytryptamine receptor 1A	Homo sapiens	72-78
26054908-6	2015	When coreleased with noradrenaline, ATP acts at postjunctional P2X1 receptors to evoke depolarisation, Ca(2+) influx, Ca(2+) sensitisation and contraction.	Norepinephrine	21-34	purinergic receptor P2X 1	Homo sapiens	63-67
26111885-3	2015	In obese mice, lentivirus mediated-FNDC5 overexpression enhanced energy expenditure, lipolysis and insulin sensitivity, and reduced hyperlipidemia, hyperglycemia, hyperinsulinism, blood pressure and norepinephrine levels; it increased hormone-sensitive lipase (HSL) expression and phosphorylation, and reduced perilipin level and adipocyte diameter in adipose tissues.	Norepinephrine	199-213	fibronectin type III domain containing 5	Mus musculus	35-40
25854989-3	2015	An alternative strategy for the modulation of sympathetic nerve function is to reduce the biosynthesis of noradrenaline (NA) by inhibiting dopamine beta-hydroxylase (DbetaH), the enzyme that catalyzes the conversion of dopamine (DA) to NA in the sympathetic nerves.	Norepinephrine	106-119	dopamine beta-hydroxylase	Rattus norvegicus	139-164
25854989-3	2015	An alternative strategy for the modulation of sympathetic nerve function is to reduce the biosynthesis of noradrenaline (NA) by inhibiting dopamine beta-hydroxylase (DbetaH), the enzyme that catalyzes the conversion of dopamine (DA) to NA in the sympathetic nerves.	Norepinephrine	106-119	dopamine beta-hydroxylase	Rattus norvegicus	166-172
25935138-7	2015	Additionally, overexpression of HSP70 via transfection with the pEGFP-rHSP70 plasmid attenuated norepinephrine (NE)-induced apoptosis.	Norepinephrine	96-110	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	32-37
25942044-4	2015	Co-administration of the 5-HT1A receptor (5-HT1AR) antagonist WAY-100635 reversed the negative effects of acute fluoxetine, a serotonin reuptake inhibitor, but not reboxetine, a norepinephrine reuptake inhibitor, supporting the involvement of 5-HT1AR in mediating the negative consequences of acute selective serotonin reuptake inhibitor (SSRI) treatment.	Norepinephrine	178-192	5-hydroxytryptamine receptor 1A	Homo sapiens	25-40
25942044-4	2015	Co-administration of the 5-HT1A receptor (5-HT1AR) antagonist WAY-100635 reversed the negative effects of acute fluoxetine, a serotonin reuptake inhibitor, but not reboxetine, a norepinephrine reuptake inhibitor, supporting the involvement of 5-HT1AR in mediating the negative consequences of acute selective serotonin reuptake inhibitor (SSRI) treatment.	Norepinephrine	178-192	5-hydroxytryptamine receptor 1A	Homo sapiens	42-49
25581910-8	2015	CPM induced the release of norepinephrine in the spinal cord and was partially blocked by intrathecal idazoxan or dopamine beta-hydroxylase-saporin.	Norepinephrine	27-41	dopamine beta-hydroxylase	Rattus norvegicus	114-139
25903953-7	2015	The association with noradrenaline remained significant also when adjusted for LVEF and plasma BNP, suggesting a significant contribution of adrenals to the circulating pool of catecholamines in subjects with systolic HF.	Norepinephrine	21-34	natriuretic peptides B	Sus scrofa	95-98
25793511-10	2015	Central GLP-1R activation also increased NTS expression of dopamine-beta-hydroxylase, a key enzyme in noradrenaline synthesis, indicating a biological link between these two systems.	Norepinephrine	102-115	dopamine beta-hydroxylase	Rattus norvegicus	59-84
25520009-9	2015	We conclude that the sustained stimulatory effect of locally elevated norepinephrine on ENaC-mediated Na(+) absorption may contribute to the hypertensive effect of increased renal sympathetic activity.	Norepinephrine	70-84	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	88-92
26158633-5	2015	Moreover, CRY1 mRNA expression was inversely correlated with the plasma level of noradrenaline (r = -0.36, p &lt; 0.05), while PER3, CRY2, and BMAL1 mRNA expression directly correlated with the plasma level of noradrenaline (r = 0.55, r = 0.66, and r = 0.57, respectively; p &lt; 0.001).	Norepinephrine	81-94	cryptochrome circadian regulator 1	Homo sapiens	10-14
26732055-4	2015	The main action of G-CSF - G-CSFR linkage is stimulation of the production, mobilization, survival and chemotaxis of neutrophils, but there are many other G-CSF effects: growth and migration of endothelial cells, decrease of norepinephrine reuptake, increase in osteoclastic activity and decrease in osteoblast activity.	Norepinephrine	225-239	colony stimulating factor 3	Homo sapiens	19-24
26732055-4	2015	The main action of G-CSF - G-CSFR linkage is stimulation of the production, mobilization, survival and chemotaxis of neutrophils, but there are many other G-CSF effects: growth and migration of endothelial cells, decrease of norepinephrine reuptake, increase in osteoclastic activity and decrease in osteoblast activity.	Norepinephrine	225-239	colony stimulating factor 3	Homo sapiens	27-33
26732055-4	2015	The main action of G-CSF - G-CSFR linkage is stimulation of the production, mobilization, survival and chemotaxis of neutrophils, but there are many other G-CSF effects: growth and migration of endothelial cells, decrease of norepinephrine reuptake, increase in osteoclastic activity and decrease in osteoblast activity.	Norepinephrine	225-239	colony stimulating factor 3	Homo sapiens	27-32
25515516-5	2015	P2X1 receptors expressed in blood vessels can be activated by ATP coreleased with noradrenaline as a sympathetic neurotransmitter, leading to smooth muscle depolarisation and contraction.	Norepinephrine	82-95	purinergic receptor P2X 1	Homo sapiens	0-4
24809685-10	2015	However, the presently observed trend towards CpG-specific MAO-A gene hypomethylation-possibly via increased gene expression and consecutively decreased serotonin and/or norepinephrine availability-to potentially drive impaired antidepressant treatment response in female patients might be worthwhile to be followed up in larger pharmacoepigenetic studies.	Norepinephrine	170-184	monoamine oxidase A	Homo sapiens	59-64
25584932-4	2015	Black and Hispanic populations are known to have a higher prevalence of cardiovascular risk factors and disease, and a substantial proportion of black and Hispanic individuals possess genotypes of the cytochrome P450 (CYP) 2C9 enzyme involved in the metabolism of many NSAIDs and the CYP2D6 enzyme involved in metabolism of the dual opioid agonist/norepinephrine-serotonin reuptake inhibitor tramadol.	Norepinephrine	348-362	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	201-226
25217656-8	2014	Urinary norepinephrine excretion for 24 h, as an indicator of sympathoexcitation, was significantly lower in GFAP/AT1RKO-MI mice than in control-MI mice.	Norepinephrine	8-22	glial fibrillary acidic protein	Mus musculus	109-113
24803315-0	2014	The stress-related hormone norepinephrine induced upregulation of Nix, contributing to ECM protein expression.	Norepinephrine	27-41	multimerin 1	Homo sapiens	87-90
25009110-3	2014	The norepinephrine system originating mainly in the locus coeruleus (LC) is defective in Rett syndrome and Mecp2-null mice.	Norepinephrine	4-18	methyl CpG binding protein 2	Mus musculus	107-112
24870806-2	2014	Norepinephrine (NE) released from these neurons is reported to augment antibody production in response to an immune challenge via an action at the beta2-adrenergic receptor (beta2AR).	Norepinephrine	0-14	adrenergic receptor, beta 2	Mus musculus	147-172
24870806-2	2014	Norepinephrine (NE) released from these neurons is reported to augment antibody production in response to an immune challenge via an action at the beta2-adrenergic receptor (beta2AR).	Norepinephrine	0-14	adrenergic receptor, beta 2	Mus musculus	174-181
24912137-8	2014	Results show that the adenosine A2a receptor agonist, CGS 21680, increases neurotransmitter release, in particular, glutamate and noradrenaline and such response is mediated by protein kinase A activation, which in turn increased synapsin I phosphorylation.	Norepinephrine	130-143	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	177-193
24799612-8	2014	Because the 2 protein kinases, STE20p-related proline- and alanine-rich kinase (encoded by STK39) and oxidative stress-response kinase 1, phosphorylate and activate NCC, we examined their roles in norepinephrine effects.	Norepinephrine	197-211	serine/threonine kinase 39	Mus musculus	91-96
24560685-4	2014	Noradrenaline can modulate both lipolysis (via alpha2- and beta3-ARs) and lipogenesis (via alpha1- and beta3-ARs).	Norepinephrine	0-13	adrenoceptor beta 3	Homo sapiens	47-68
24560685-4	2014	Noradrenaline can modulate both lipolysis (via alpha2- and beta3-ARs) and lipogenesis (via alpha1- and beta3-ARs).	Norepinephrine	0-13	adrenoceptor alpha 1D	Homo sapiens	91-108
24583232-8	2014	In addition, the immune changes caused by the GLS gene interventions in the IN were accompanied by alteration in norepinephrine content in the spleen and mesenteric lymph nodes but not by changes in adrenocortical and thyroid hormone levels in serum.	Norepinephrine	113-127	glutaminase	Homo sapiens	46-49
24452243-11	2014	As Agtrap and Agtr1b not only participate in the "uptake of norepinephrine" and "blood pressure", but also in the "behavior" of SHRSP at 6 weeks of age, our data demonstrate a close association between hypertension and ADHD.	Norepinephrine	60-74	angiotensin II receptor-associated protein	Rattus norvegicus	3-9
24559277-1	2014	OBJECT: The biogenic amines (dopamine, epinephrine, norepinephrine, and serotonin) are involved in the regulation of multiple neuronal functions, and changes in monoamine concentrations in the CSF have been detected in several disorders.	Norepinephrine	52-66	colony stimulating factor 2	Homo sapiens	193-196
24711750-1	2014	Dopamine-beta-hydroxylase (DBH) is a neurotransmitter (catecholamine)-mediating enzyme, which catalyzes the formation of norepinephrine from dopamine.	Norepinephrine	121-135	dopamine beta-hydroxylase	Homo sapiens	0-25
24711750-1	2014	Dopamine-beta-hydroxylase (DBH) is a neurotransmitter (catecholamine)-mediating enzyme, which catalyzes the formation of norepinephrine from dopamine.	Norepinephrine	121-135	dopamine beta-hydroxylase	Homo sapiens	27-30
24328808-2	2014	In this paper, we review work from our laboratory and others focused on determining the neurobiological mechanisms that underlie and contribute to stress-induced relapse of cocaine use with an emphasis on the actions of corticotropin-releasing factor in the ventral tegmental area (VTA) and a key pathway from the bed nucleus of the stria terminalis to the VTA that is regulated by norepinephrine and beta adrenergic receptors.	Norepinephrine	382-396	corticotropin releasing hormone	Homo sapiens	220-250
24068832-1	2013	Inhibitors of dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine (DA) to norepinephrine (NE) in noradrenergic cells, have shown promise for the treatment of cocaine abuse disorders.	Norepinephrine	89-103	dopamine beta-hydroxylase	Rattus norvegicus	14-39
24068832-1	2013	Inhibitors of dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine (DA) to norepinephrine (NE) in noradrenergic cells, have shown promise for the treatment of cocaine abuse disorders.	Norepinephrine	89-103	dopamine beta-hydroxylase	Rattus norvegicus	41-44
23962674-4	2013	In a sample of 100 healthy adults, we studied the dependency of an individual"s size of PES on the DBH5"-ins/del polymorphism-a variation in the DBH gene associated with the production of the enzyme dopamine beta-hydroxylase, which catalyzes the conversion of dopamine to norepinephrine.	Norepinephrine	272-286	dopamine beta-hydroxylase	Homo sapiens	199-224
24058067-1	2013	Emotionally enhanced memory and susceptibility to intrusive memories after trauma have been linked to a deletion variant (i.e., a form of a gene in which certain amino acids are missing) of ADRA2B, the gene encoding subtype B of the alpha2-adrenergic receptor, which influences norepinephrine activity.	Norepinephrine	278-292	adrenoceptor alpha 2B	Homo sapiens	190-196
23731819-6	2013	Furthermore, noradrenaline, syndecan-1 and thrombomodulin levels correlated with INR and disease severity scores (noradrenaline and thrombomodulin) (all P&lt;.05).	Norepinephrine	13-26	thrombomodulin	Homo sapiens	132-146
23731819-6	2013	Furthermore, noradrenaline, syndecan-1 and thrombomodulin levels correlated with INR and disease severity scores (noradrenaline and thrombomodulin) (all P&lt;.05).	Norepinephrine	114-127	thrombomodulin	Homo sapiens	43-57
24010670-4	2013	We found that in hepatocytes isolated from Hint2(-/-) mice, the frequency of Ca(2+) oscillations induced by 1 muM noradrenaline was 150% higher than in the wild-type.	Norepinephrine	114-127	histidine triad nucleotide binding protein 2	Mus musculus	43-48
23838810-5	2013	Further, angiotensin II and norepinephrine stimulated expression of geminin in VSMCs.	Norepinephrine	28-42	geminin DNA replication inhibitor	Homo sapiens	68-75
23416088-2	2013	Dopamine beta-hydroxylase (DBH) as a catecholamine-synthesizing enzyme plays a central role in noradrenaline (NA) synthesis and turnover.	Norepinephrine	95-108	dopamine beta-hydroxylase	Homo sapiens	0-25
23416088-2	2013	Dopamine beta-hydroxylase (DBH) as a catecholamine-synthesizing enzyme plays a central role in noradrenaline (NA) synthesis and turnover.	Norepinephrine	95-108	dopamine beta-hydroxylase	Homo sapiens	27-30
23389997-7	2013	Furthermore, treatment with desipramine, an antidepressant with specific inhibitory effects on norepinephrine transport, prevented an increased dopamine beta-hydroxylase expression by chronic social defeat in the locus coeruleus and its main terminal regions such as the hippocampus, frontal cortex and amygdala.	Norepinephrine	95-109	dopamine beta-hydroxylase	Rattus norvegicus	144-169
23389997-9	2013	The present findings indicate that chronic social defeat activates the locus coeruleus-norepinephrine system by upregulating the expression of dopamine beta-hydroxylase, which may increase norepinephrine synthesis.	Norepinephrine	87-101	dopamine beta-hydroxylase	Rattus norvegicus	143-168
23389997-9	2013	The present findings indicate that chronic social defeat activates the locus coeruleus-norepinephrine system by upregulating the expression of dopamine beta-hydroxylase, which may increase norepinephrine synthesis.	Norepinephrine	189-203	dopamine beta-hydroxylase	Rattus norvegicus	143-168
23571809-9	2013	A partial correlation network showed total tau most directly related to norepinephrine and purine pathways; amyloid-beta (Ab42) was related directly to an unidentified metabolite and indirectly to 5-HIAA and MET.	Norepinephrine	72-86	microtubule associated protein tau	Homo sapiens	43-46
23356740-7	2013	Conversely, the structurally related receptor, CG16766, was internalized by a number of biogenic amines, including octopamine, dopamine, noradrenaline, adrenaline, which also were able to elevate cyclic AMP levels.	Norepinephrine	137-150	Tyramine receptor II	Drosophila melanogaster	47-54
25390808-0	2013	Acute macular neuroretinopathy associated with the use of norepinephrine reuptake inhibitors: a case series and OCT findings.	Norepinephrine	58-72	plexin A2	Homo sapiens	112-115
23497457-11	2013	PVR increased during ADA and PDA being grafted in norepinephrine group but not in vasopressin group.	Norepinephrine	50-64	PVR cell adhesion molecule	Homo sapiens	0-3
22875483-4	2013	Dopamine beta hydroxylase (DBH) is responsible for maintaining dopamine-to-norepinephrine ratio implicated in migraine pathophysiology.	Norepinephrine	75-89	dopamine beta-hydroxylase	Homo sapiens	0-25
22875483-4	2013	Dopamine beta hydroxylase (DBH) is responsible for maintaining dopamine-to-norepinephrine ratio implicated in migraine pathophysiology.	Norepinephrine	75-89	dopamine beta-hydroxylase	Homo sapiens	27-30
23433357-9	2013	RESULTS: Circulating noradrenaline and adrenaline correlated weakly but independently with syndecan-1 (rho = 0.15 and rho = 0.13, both P &lt;0.01) and thrombomodulin (rho = 0.11 and rho = 0.17, both P &lt;0.01), biomarkers of glycocalyx and endothelial cell damage, respectively.	Norepinephrine	21-34	thrombomodulin	Homo sapiens	151-165
21704393-0	2013	The regulatory effect of norepinephrine on connective tissue growth factor (CTGF) and vascular endothelial growth factor (VEGF) expression in cultured cardiac fibroblasts.	Norepinephrine	25-39	cellular communication network factor 2	Rattus norvegicus	43-74
21704393-2	2013	This study tested the hypothesis that norepinephrine (NE) induces CTGF and VEGF gene and protein expression in cardiac fibroblasts (CF) and the CTGF/VEGF complex will have an effect on angiogenesis.	Norepinephrine	38-52	cellular communication network factor 2	Rattus norvegicus	66-70
21704393-2	2013	This study tested the hypothesis that norepinephrine (NE) induces CTGF and VEGF gene and protein expression in cardiac fibroblasts (CF) and the CTGF/VEGF complex will have an effect on angiogenesis.	Norepinephrine	38-52	vascular endothelial growth factor A	Rattus norvegicus	75-79
23302980-12	2013	CONCLUSIONS: This study provides evidence that anandamide and PEA induce peripheral antinociception activating CB1 and CB2 cannabinoid receptors, respectively, stimulating an endogenous norepinephrine release that activates peripheral adrenoceptors inducing antinociception.	Norepinephrine	186-200	cannabinoid receptor 2	Rattus norvegicus	119-122
23022576-1	2013	Ascorbic acid enhances synthesis of norepinephrine from dopamine in adrenal chromaffin cells by serving as a co-factor for chromaffin granule dopamine beta-hydroxylase (DbetaH).	Norepinephrine	36-50	dopamine beta-hydroxylase	Homo sapiens	142-167
23022576-1	2013	Ascorbic acid enhances synthesis of norepinephrine from dopamine in adrenal chromaffin cells by serving as a co-factor for chromaffin granule dopamine beta-hydroxylase (DbetaH).	Norepinephrine	36-50	dopamine beta-hydroxylase	Homo sapiens	169-175
23022576-6	2013	Norepinephrine accumulation after 60 min of incubation with 100 muM dopamine was half-maximal at intracellular ascorbate concentrations of 0.2-0.5 mM, which fits well with the literature K(m) for ascorbate of DbetaH using dopamine as a substrate.	Norepinephrine	0-14	dopamine beta-hydroxylase	Homo sapiens	209-215
22771532-7	2012	This revealed that Bergmann glia lacking type 2 IP(3)R exhibited reduced responses to noradrenaline or histamine compared with wild-type Bergmann glia and Bergmann glia with other genotypes, suggesting that type 2 IP(3)R is the major functional IP(3)R subtype involved in agonist-induced Ca(2+) release in Bergmann glia, although types 1 and 3 IP(3)R could also contribute to rapid agonist-induced [Ca(2+)](i) elevation in the processes.	Norepinephrine	86-99	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	48-54
22771532-7	2012	This revealed that Bergmann glia lacking type 2 IP(3)R exhibited reduced responses to noradrenaline or histamine compared with wild-type Bergmann glia and Bergmann glia with other genotypes, suggesting that type 2 IP(3)R is the major functional IP(3)R subtype involved in agonist-induced Ca(2+) release in Bergmann glia, although types 1 and 3 IP(3)R could also contribute to rapid agonist-induced [Ca(2+)](i) elevation in the processes.	Norepinephrine	86-99	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	214-220
22771532-7	2012	This revealed that Bergmann glia lacking type 2 IP(3)R exhibited reduced responses to noradrenaline or histamine compared with wild-type Bergmann glia and Bergmann glia with other genotypes, suggesting that type 2 IP(3)R is the major functional IP(3)R subtype involved in agonist-induced Ca(2+) release in Bergmann glia, although types 1 and 3 IP(3)R could also contribute to rapid agonist-induced [Ca(2+)](i) elevation in the processes.	Norepinephrine	86-99	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	214-220
22771532-7	2012	This revealed that Bergmann glia lacking type 2 IP(3)R exhibited reduced responses to noradrenaline or histamine compared with wild-type Bergmann glia and Bergmann glia with other genotypes, suggesting that type 2 IP(3)R is the major functional IP(3)R subtype involved in agonist-induced Ca(2+) release in Bergmann glia, although types 1 and 3 IP(3)R could also contribute to rapid agonist-induced [Ca(2+)](i) elevation in the processes.	Norepinephrine	86-99	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	214-220
22739762-9	2012	With administration of norepinephrine there was a 2.2% (1.0-4.3%) decrease in skin oxygen saturation and scO2 decreased 6.2% (4.2-8.0%), with scapO2 remaining unaffected.	Norepinephrine	23-37	synthesis of cytochrome C oxidase 2	Homo sapiens	105-109
22739762-11	2012	However, a commonly used vasopressor norepinephrine disturbs skin oxygen saturation to an extent that influences scO2.	Norepinephrine	37-51	synthesis of cytochrome C oxidase 2	Homo sapiens	113-117
22685264-0	2012	Different signaling mechanisms are involved in the norepinephrine-stimulated TORC1 and TORC2 nuclear translocation in rat pinealocytes.	Norepinephrine	51-65	CREB regulated transcription coactivator 2	Rattus norvegicus	87-92
22445279-2	2012	Dopamine beta-hydroxylase (DBH) is an intracellular enzyme catalyzing the conversion of dopamine to noradrenaline.	Norepinephrine	100-113	dopamine beta-hydroxylase	Homo sapiens	0-25
22445279-2	2012	Dopamine beta-hydroxylase (DBH) is an intracellular enzyme catalyzing the conversion of dopamine to noradrenaline.	Norepinephrine	100-113	dopamine beta-hydroxylase	Homo sapiens	27-30
21995501-0	2012	Environmental enrichment in male CD-1 mice promotes aggressive behaviors and elevated corticosterone and brain norepinephrine activity in response to a mild stressor.	Norepinephrine	111-125	CD1 antigen complex	Mus musculus	33-37
20641293-2	2004	MAO-A preferentially oxidizes serotonin and noradrenaline, whereas MAO-B preferentially oxidizes phenethylamine.	Norepinephrine	44-57	monoamine oxidase A	Homo sapiens	0-5
22197914-5	2012	Additionally, the monoamine neurotransmitters serotonin (5-HT), noradrenaline (NA) and dopamine (DA) levels involved in the antidepressant-like effect of HCE were also measured in the mice brain regions of frontal cortex and hippocampus.	Norepinephrine	64-77	RNA guanylyltransferase and 5'-phosphatase	Mus musculus	154-157
22192161-1	2012	Tapentadol is a newly approved novel analgesic drug with a dual mode of action: a mu-opioid agonist and an inhibitor of norepinephrine reuptake (MOR-NRI).	Norepinephrine	120-134	opioid receptor mu 1	Homo sapiens	145-148
22761865-3	2012	The dopamine beta hydroxylase (DBH) gene is thought to regulate the differential availability of dopamine and norepinephrine in prefrontal cortex.	Norepinephrine	110-124	dopamine beta-hydroxylase	Homo sapiens	4-29
22761865-3	2012	The dopamine beta hydroxylase (DBH) gene is thought to regulate the differential availability of dopamine and norepinephrine in prefrontal cortex.	Norepinephrine	110-124	dopamine beta-hydroxylase	Homo sapiens	31-34
21809008-2	2012	The use of the norepinephrine reuptake inhibitor, atomoxetine, to treat ADHD suggests that the activity of the norepinephrine transporter (NET) may be important in regulating impulsive behavior.	Norepinephrine	15-29	solute carrier family 6 member 2	Rattus norvegicus	111-137
21809008-2	2012	The use of the norepinephrine reuptake inhibitor, atomoxetine, to treat ADHD suggests that the activity of the norepinephrine transporter (NET) may be important in regulating impulsive behavior.	Norepinephrine	15-29	solute carrier family 6 member 2	Rattus norvegicus	139-142
22015761-5	2011	Brainstem sections were immunohistochemically processed for dopamine-beta-hydroxylase, a marker for norepinephrine.	Norepinephrine	100-114	dopamine beta-hydroxylase	Rattus norvegicus	60-85
21708146-11	2011	The mechanism involved in both cases is that SAMe is required for the conversion of epinephrine from norepinephrine by phenylethanolamine methyltransferase (PNMT).	Norepinephrine	101-115	phenylethanolamine-N-methyltransferase	Rattus norvegicus	119-155
21708146-11	2011	The mechanism involved in both cases is that SAMe is required for the conversion of epinephrine from norepinephrine by phenylethanolamine methyltransferase (PNMT).	Norepinephrine	101-115	phenylethanolamine-N-methyltransferase	Rattus norvegicus	157-161
21471955-1	2011	Dopamine-beta-hydroxylase (DbetaH) deficiency is a rare genetic syndrome characterized by the complete absence of norepinephrine in the peripheral and the central nervous system.	Norepinephrine	114-128	dopamine beta-hydroxylase	Homo sapiens	0-25
21471955-1	2011	Dopamine-beta-hydroxylase (DbetaH) deficiency is a rare genetic syndrome characterized by the complete absence of norepinephrine in the peripheral and the central nervous system.	Norepinephrine	114-128	dopamine beta-hydroxylase	Homo sapiens	27-33
20070977-0	2011	Exogenous norepinephrine correlates with macrophage endoplasmic reticulum stress response in association with XBP-1.	Norepinephrine	10-24	X-box binding protein 1	Homo sapiens	110-115
20070977-9	2011	Inhibition of XBP1 expression with siRNA treatment significantly inhibited the immunostimulatory effects of low concentrations of norepinephrine.	Norepinephrine	130-144	X-box binding protein 1	Homo sapiens	14-18
20070977-10	2011	CONCLUSIONS: Our data convincingly indicated that norepinephrine exerted immunostimulatory actions on macrophages at low concentrations, suggesting that the underlying mechanisms are related to endoplasmic reticulum stress via XBP1.	Norepinephrine	50-64	X-box binding protein 1	Homo sapiens	227-231
21354320-9	2011	A selective sGC inhibitor, ODQ (3muM), prevented the endotoxin-induced decrease in the E(max) values and increase in the EC(50) values of norepinephrine in endothelium-intact aortic rings isolated from endotoxemic rats in vitro.	Norepinephrine	138-152	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	12-15
21185902-6	2011	Increased functioning of noradrenaline (along with other central and peripheral regulating mechanisms) may be an important factor associated with cardiovascular changes in AWS.	Norepinephrine	25-38	jagged canonical Notch ligand 1	Homo sapiens	172-175
21272571-6	2011	Clobenpropit (histamine H(3) receptor antagonist, 1muM) canceled the alpha-methylhistamine-induced decrease in the periarterial nerve stimulation-induced vasoconstriction and noradrenaline release and periarterial nerve stimulation-induced vasodilation.	Norepinephrine	175-188	histamine receptor H3	Rattus norvegicus	14-37
21209083-1	2011	Human norepinephrine (NE) deficiency (or dopamine beta-hydroxylase (DBH) deficiency) is a rare congenital disorder of primary autonomic failure, in which neurotransmitters NE and epinephrine are undetectable.	Norepinephrine	6-20	dopamine beta-hydroxylase	Homo sapiens	41-66
21209083-1	2011	Human norepinephrine (NE) deficiency (or dopamine beta-hydroxylase (DBH) deficiency) is a rare congenital disorder of primary autonomic failure, in which neurotransmitters NE and epinephrine are undetectable.	Norepinephrine	6-20	dopamine beta-hydroxylase	Homo sapiens	68-71
21131476-8	2011	BK beta1-KO mesenteric arteries in vitro demonstrated diminished contractile responses to paxilline, increased reactivity to Bay K 8644 and norepinephrine (NE), and maintained relaxation to isoproterenol.	Norepinephrine	140-154	potassium large conductance calcium-activated channel, subfamily M, beta member 1	Mus musculus	0-8
21185183-1	2011	Compounds with combined norepinephrine reuptake inhibitor (NRI) and serotonin 1A (5-HT(1A)) partial agonist pharmacology may offer a new therapeutic approach for treating symptoms of neuropsychiatric disorders including ADHD, depression, and anxiety.	Norepinephrine	24-38	5-hydroxytryptamine receptor 1A	Homo sapiens	82-90
22216270-13	2011	Pretreatment with pH 5.0 QX-314, and not pH 7.4 QX-314, alleviated pain behavior, inhibited the increased spinal Fos protein and p-ERK expression induced by pH 5.0 PBS or norepinephrine, blocked sodium currents and abolished the production of action potentials evoked by current injection.	Norepinephrine	171-185	FBJ osteosarcoma oncogene	Mus musculus	113-116
21858052-5	2011	The present results suggest that neurons expressing NK1 receptor within the MDH might be modulated by GABAergic and glycinergic inhibitory intrinsic neurons located in the MDH and 5-HT- or norepinephrine (NE)-containing descending fibers originated from structures in the brainstem.	Norepinephrine	189-203	tachykinin receptor 1	Rattus norvegicus	52-64
21070631-2	2010	Dopamine beta-hydroxylase (DBH) catalyses the conversion of dopamine to noradrenaline.	Norepinephrine	72-85	dopamine beta-hydroxylase	Homo sapiens	0-25
21070631-2	2010	Dopamine beta-hydroxylase (DBH) catalyses the conversion of dopamine to noradrenaline.	Norepinephrine	72-85	dopamine beta-hydroxylase	Homo sapiens	27-30
20204405-1	2010	PURPOSE: Inhibitors of monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades neurotransmitters including serotonin and norepinephrine, are commonly used to treat neurological conditions including depression.	Norepinephrine	130-144	monoamine oxidase A	Homo sapiens	23-42
20204405-1	2010	PURPOSE: Inhibitors of monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades neurotransmitters including serotonin and norepinephrine, are commonly used to treat neurological conditions including depression.	Norepinephrine	130-144	monoamine oxidase A	Homo sapiens	44-48
20679667-5	2010	Affected males in this family showed an inherited hemizygous deletion restricted to NDP and two immediately telomeric genes, monoamine oxidase-B (MAO-B) and monoamine oxidase-A (MAO-A), which encode closely related enzymes that metabolize biogenic amines including serotonin, dopamine, and norepinephrine.	Norepinephrine	290-304	monoamine oxidase A	Homo sapiens	157-176
20679667-5	2010	Affected males in this family showed an inherited hemizygous deletion restricted to NDP and two immediately telomeric genes, monoamine oxidase-B (MAO-B) and monoamine oxidase-A (MAO-A), which encode closely related enzymes that metabolize biogenic amines including serotonin, dopamine, and norepinephrine.	Norepinephrine	290-304	monoamine oxidase A	Homo sapiens	178-183
20144675-5	2010	Likewise, norepinephrine-depletion increased neuroinflammation compared to transgenic controls as verified by macrophage inflammatory protein-1alpha and -1beta gene expression analysis.	Norepinephrine	10-24	chemokine (C-C motif) ligand 3	Mus musculus	110-159
20736996-3	2010	We hypothesized that disulfiram"s inhibition of dopamine beta-hydroxylase (DBH), the catecholamine biosynthetic enzyme that converts dopamine (DA) to norepinephrine (NE) in noradrenergic neurons, underlies the drug"s ability to treat cocaine dependence.	Norepinephrine	150-164	dopamine beta-hydroxylase	Rattus norvegicus	48-73
20736996-3	2010	We hypothesized that disulfiram"s inhibition of dopamine beta-hydroxylase (DBH), the catecholamine biosynthetic enzyme that converts dopamine (DA) to norepinephrine (NE) in noradrenergic neurons, underlies the drug"s ability to treat cocaine dependence.	Norepinephrine	150-164	dopamine beta-hydroxylase	Rattus norvegicus	75-78
20728435-5	2010	A small number of HSD2 immunoreactive neurons was also labeled for dopamine-beta-hydroxylase (DBH), an enzyme involved in norepinephrine biosynthesis.	Norepinephrine	122-136	dopamine beta-hydroxylase	Rattus norvegicus	94-97
20729197-1	2010	alpha(2)-Adrenoceptors belong to the family of adrenergic receptors, which regulate the neuronal release of norepinephrine as part of a negative feedback loop.	Norepinephrine	108-122	adrenergic receptor, alpha 2b	Mus musculus	0-22
20485326-1	2010	Monoamine oxidases (MAO-A and MAO-B) have a key role in the degradation of amine neurotransmitters, such as dopamine, norepinephrine and serotonin.	Norepinephrine	118-132	monoamine oxidase A	Homo sapiens	20-25
20935665-3	2010	BAT thermogenesis is triggered by the release of norepinephrine from its sympathetic nerve terminals, stimulating beta3-adrenoceptors that turns on a cascade of intracellular events ending in activation of uncoupling protein-1 (UCP-1).	Norepinephrine	49-63	uncoupling protein 1	Homo sapiens	206-233
20530737-9	2010	Principally in accordance with this, a higher than standard dose of norepinephrine was needed to obtain full norepinephrine-induced thermogenesis in the Cav1-ablated mice; the higher dose was also needed for the Cav1-ablated mice to be able to utilize fat as a substrate for thermogenesis.	Norepinephrine	68-82	caveolin 1, caveolae protein	Mus musculus	153-157
20530737-9	2010	Principally in accordance with this, a higher than standard dose of norepinephrine was needed to obtain full norepinephrine-induced thermogenesis in the Cav1-ablated mice; the higher dose was also needed for the Cav1-ablated mice to be able to utilize fat as a substrate for thermogenesis.	Norepinephrine	68-82	caveolin 1, caveolae protein	Mus musculus	212-216
20530737-9	2010	Principally in accordance with this, a higher than standard dose of norepinephrine was needed to obtain full norepinephrine-induced thermogenesis in the Cav1-ablated mice; the higher dose was also needed for the Cav1-ablated mice to be able to utilize fat as a substrate for thermogenesis.	Norepinephrine	109-123	caveolin 1, caveolae protein	Mus musculus	153-157
20597975-8	2010	Of these, norepinephrine neurotransmission in the arcuate nucleus and prefrontal cortex was differentially altered in GHSR KO mice.	Norepinephrine	10-24	growth hormone secretagogue receptor	Mus musculus	118-122
20641888-2	2004	In addition, the H3 receptor (H3R) is also known to regulate the synthesis and release of histamine itself and other neurotransmitters such as noradrenalin, dopamine, and acetylcholine (1, 2).	Norepinephrine	143-155	histamine receptor H3	Homo sapiens	17-28
20641888-2	2004	In addition, the H3 receptor (H3R) is also known to regulate the synthesis and release of histamine itself and other neurotransmitters such as noradrenalin, dopamine, and acetylcholine (1, 2).	Norepinephrine	143-155	histamine receptor H3	Homo sapiens	30-33
20374255-0	2010	Role of 5-HT 2B receptors in cardiomyocyte apoptosis in noradrenaline-induced cardiomyopathy in rats.	Norepinephrine	56-69	5-hydroxytryptamine receptor 2B	Rattus norvegicus	8-15
20420875-5	2010	Lack of alpha-synuclein did not modify the relaxant responses to the endothelium-dependent (acetylcholine) and -independent (sodium nitroprusside) vasodilators, but resulted in a greater than normal norepinephrine-induced vasoconstriction along with a lowered response to dopamine, suggesting potential presynaptic changes in dopamine and norepinephrine releases in knockout mice.	Norepinephrine	199-213	synuclein, alpha	Mus musculus	8-23
20430042-6	2010	Homozygosity for the DBH T allele, which is associated with relatively increased dopamine and decreased noradrenaline levels, resulted in a significant increase in rightwards spatial bias relative to the C allele.	Norepinephrine	104-117	dopamine beta-hydroxylase	Homo sapiens	21-24
20215412-0	2010	Transmembrane segment five serines of the D4 dopamine receptor uniquely influence the interactions of dopamine, norepinephrine, and Ro10-4548.	Norepinephrine	112-126	dopamine receptor D4	Homo sapiens	42-62
19941049-2	2010	COMT and MAOA each contribute to the enzymatic degradation of dopamine and noradrenaline.	Norepinephrine	75-88	monoamine oxidase A	Homo sapiens	9-13
19961846-0	2010	Presynaptic BK type Ca(2+)-activated K(+) channels are involved in prostanoid TP receptor-mediated inhibition of noradrenaline release from the rat gastric sympathetic nerves.	Norepinephrine	113-126	thromboxane A2 receptor	Rattus norvegicus	67-89
19961846-1	2010	Previously, we reported that prostanoid TP receptor mediates the inhibition of electrically evoked noradrenaline release from gastric sympathetic nerves in rats.	Norepinephrine	99-112	thromboxane A2 receptor	Rattus norvegicus	29-51
19961846-6	2010	These results suggest that BK type Ca(2+)-activated K(+) channels are involved in prostanoid TP receptor-mediated inhibition of electrically evoked noradrenaline release from the gastric sympathetic nerve terminals in rats.	Norepinephrine	148-161	thromboxane A2 receptor	Rattus norvegicus	82-104
19757024-2	2010	Synthesis of norepinephrine from dopamine is catalyzed by the enzyme dopamine beta-hydroxylase and numerous polymorphisms in the DBH gene have been found to exert their direct influence on the enzyme activity independently.	Norepinephrine	13-27	dopamine beta-hydroxylase	Homo sapiens	69-94
19757024-2	2010	Synthesis of norepinephrine from dopamine is catalyzed by the enzyme dopamine beta-hydroxylase and numerous polymorphisms in the DBH gene have been found to exert their direct influence on the enzyme activity independently.	Norepinephrine	13-27	dopamine beta-hydroxylase	Homo sapiens	129-132
20036056-0	2010	Nociceptin/Orphanin FQ in PAG modulates the release of amino acids, serotonin and norepinephrine in the rostral ventromedial medulla and spinal cord in rats.	Norepinephrine	82-96	prepronociceptin	Rattus norvegicus	0-10
20036056-0	2010	Nociceptin/Orphanin FQ in PAG modulates the release of amino acids, serotonin and norepinephrine in the rostral ventromedial medulla and spinal cord in rats.	Norepinephrine	82-96	prepronociceptin	Rattus norvegicus	11-22
19932741-7	2010	By contrast, in the raphe region of Mecp2-null mice, there were significant decreases in 5-HT and noradrenaline levels, but these differences later disappeared and there was no change in the number of 5-HT-immunoreactive neuronal cell bodies.	Norepinephrine	98-111	methyl CpG binding protein 2	Mus musculus	36-41
19909795-2	2010	This study explored whether hormone regulation/dysregulation of these systems could be related to gonadal steroid effects on catechol-O-methyltransferase and monoamine oxidase which are principal enzymatic controllers of forebrain dopamine, serotonin and norepinephrine levels.	Norepinephrine	255-269	catechol-O-methyltransferase	Rattus norvegicus	125-153
19854260-5	2010	Noradrenaline (1 microM), adrenaline (1 microM), and dopamine (100 microM) showed a maximal increase in NT-3 cellular content after 6h treatment causing a 1.9-, 1.8- and 2.7-fold elevation, respectively.	Norepinephrine	0-13	neurotrophin 3	Rattus norvegicus	104-108
19854260-6	2010	Prior to the observed increase in NT-3 protein levels, the examined catecholamines increased NT-3 mRNA levels with maximal effects observed after 1h (noradrenaline) and 2h (adrenaline and dopamine) of incubation causing 2.4-, 2.6- and 3-fold elevation, respectively.	Norepinephrine	150-163	neurotrophin 3	Rattus norvegicus	93-97
19914944-11	2010	UCN2 also induced a short-lived rise in plasma norepinephrine levels (P=0.006).	Norepinephrine	47-61	urocortin-2	Ovis aries	0-4
19890267-1	2010	Reversible inhibitors of monoamine oxidase-A (RIMA) inhibit the breakdown of three major neurotransmitters, serotonin, norepinephrine and dopamine, offering a multi-neurotransmitter strategy for the treatment of depression.	Norepinephrine	119-133	monoamine oxidase A	Homo sapiens	25-44
21171669-2	2010	A strategy for directly modulating sympathetic nerve function is to reduce the biosynthesis of norepinephrine (noradrenaline) via inhibition of dopamine-beta-hydroxylase (DbetaH).	Norepinephrine	95-109	dopamine beta-hydroxylase	Homo sapiens	144-169
21171669-2	2010	A strategy for directly modulating sympathetic nerve function is to reduce the biosynthesis of norepinephrine (noradrenaline) via inhibition of dopamine-beta-hydroxylase (DbetaH).	Norepinephrine	111-124	dopamine beta-hydroxylase	Homo sapiens	144-169
19910432-1	2009	UNLABELLED: The histamine H(3) receptor is a G-protein-coupled presynaptic auto- and heteroreceptor whose activation leads to a decrease in the release of several neurotransmitters including histamine, acetycholine, noradrenaline, and dopamine.	Norepinephrine	216-229	histamine receptor H3	Homo sapiens	16-39
19295483-8	2009	The norepinephrine dose and plasma concentrations of soluble endothelial leukocyte adhesion molecule 1 and soluble intercellular adhesion molecule 1 significantly (P &lt; 0.05) decreased in the PMX greater-than-2-h (prolonged) group than in the PMX 2-h (conventional) group (-17.8 +/- 14.6 vs. -1.8 +/- 2.7 microg/min, -143.0 +/- 111.0 vs. 0 +/- 2.8 ng/mL, and -126.2 +/- 144.9 vs. 16.5 +/- 108.1 ng/mL, respectively).	Norepinephrine	4-18	selectin E	Homo sapiens	61-102
19482560-1	2009	In this study we investigated the changes in norepinephrine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) gene expression in the stellate ganglia of naive controls and long-term socially isolated (12 weeks) adult rats and the response of these animals to additional immobilization stress.	Norepinephrine	45-59	phenylethanolamine-N-methyltransferase	Rattus norvegicus	144-182
19482560-1	2009	In this study we investigated the changes in norepinephrine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) gene expression in the stellate ganglia of naive controls and long-term socially isolated (12 weeks) adult rats and the response of these animals to additional immobilization stress.	Norepinephrine	45-59	phenylethanolamine-N-methyltransferase	Rattus norvegicus	184-188
19560519-2	2009	Dopamine-beta-hydroxylase (DBH) is the enzyme responsible for conversion of dopamine to norepinephrine, and thus plays an important role in controlling dispositions of these neurotransmitters.	Norepinephrine	88-102	dopamine beta-hydroxylase	Homo sapiens	0-25
19560519-2	2009	Dopamine-beta-hydroxylase (DBH) is the enzyme responsible for conversion of dopamine to norepinephrine, and thus plays an important role in controlling dispositions of these neurotransmitters.	Norepinephrine	88-102	dopamine beta-hydroxylase	Homo sapiens	27-30
19713945-0	2009	S100B modulates the hemodynamic response to norepinephrine stimulation.	Norepinephrine	44-58	S100 protein, beta polypeptide, neural	Mus musculus	0-5
19713945-1	2009	BACKGROUND: We have previously reported that S100B acts as an intrinsic negative regulator of the myocardial hypertrophic response to norepinephrine (NE).	Norepinephrine	134-148	S100 protein, beta polypeptide, neural	Mus musculus	45-50
19553916-7	2009	Taken together these studies show that VEGF is necessary for the behavioral effects of the SSRI fluoxetine, as well as norepinephrine selective reuptake inhibitor, and that these effects may be mediated by 5-HT1A receptors located on neurons and endothelial cells.	Norepinephrine	119-133	vascular endothelial growth factor A	Rattus norvegicus	39-43
19234788-2	2009	Menkes disease can be detected by relatively high concentrations of dopamine (DA) and its metabolites compared to norepinephrine (NE) and its metabolites, presumably because dopamine-beta-hydroxylase (DBH) requires copper as a co-factor.	Norepinephrine	114-128	dopamine beta-hydroxylase	Homo sapiens	201-204
18958498-3	2009	Because cyclic adenosine 3",5"-monophosphate stimulates the dopamine beta hydroxylase gene, an activating mutation of the Gsalpha protein may cause the hyperproduction of norepinephrine via dopamine.	Norepinephrine	171-185	dopamine beta-hydroxylase	Homo sapiens	60-85
19470879-3	2009	We found that the beta(2)-adrenoceptor antagonist ICI 118,551 (ICI) evoked a decrease of vascular tone in large pulmonary arteries and reduced the sensitivity of pulmonary arteries toward different contracting agents, eg, norepinephrine, serotonin, or endothelin.	Norepinephrine	222-236	adrenergic receptor, beta 2	Mus musculus	18-38
19470879-5	2009	Pharmacological experiments proved that the right shift of the norepinephrine dose-response curve by ICI was mediated via a beta(2)-adrenoceptor/G(i/o) protein-dependent pathway enhancing NO production in the endothelium; these results were corroborated in beta-adrenoceptor and endothelial NO synthase knockout mice where ICI had no effect.	Norepinephrine	63-77	adrenergic receptor, beta 2	Mus musculus	124-144
19506905-5	2009	Indeed, a series of recent studies, particularly concentrating on the serotonin and norepinephrine metabolising enzyme, monoamine oxidase A, has emphasised the necessity of examining gene by environmental interactions if the contributions of individual loci are to be understood.	Norepinephrine	84-98	monoamine oxidase A	Homo sapiens	120-139
19362092-8	2009	Soluble guanylyl cyclase (sGC) inhibition caused a greater increase of evoked norepinephrine release in the l-arginine fed SHR compared with the non-fed SHR.	Norepinephrine	78-92	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	0-24
19362092-8	2009	Soluble guanylyl cyclase (sGC) inhibition caused a greater increase of evoked norepinephrine release in the l-arginine fed SHR compared with the non-fed SHR.	Norepinephrine	78-92	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	26-29
19038360-4	2009	It was observed that cell preincubation with insulin, IGF-I, EGF or PDGF markedly reduced the intracellular calcium increase observed in response to noradrenaline.	Norepinephrine	149-162	insulin-like growth factor 1	Rattus norvegicus	54-59
19038360-4	2009	It was observed that cell preincubation with insulin, IGF-I, EGF or PDGF markedly reduced the intracellular calcium increase observed in response to noradrenaline.	Norepinephrine	149-162	epidermal growth factor	Rattus norvegicus	61-64
19046481-9	2009	In contrast, in vitro exposure of cultured glial cells to noradrenaline suppressed IL-1beta, TNF-alpha, iNOS and CD40 expression.	Norepinephrine	58-71	CD40 molecule	Rattus norvegicus	113-117
19194374-10	2009	Monoamines such as noradrenalin and serotonin may modulate these relationships, given that their metabolism varies according to MAOA variants, and that they modulate both emotional brain systems and antisocial aggression.	Norepinephrine	19-31	monoamine oxidase A	Homo sapiens	128-132
19217831-7	2009	The peak values of IL-6 and IL-8 also correlated positively with the peak values of noradrenaline (r=0.603 and r=0.681, respectively).These results suggest that a pronounced activation of the sympathetic nervous system and the inflammatory response occurs in acute stage of SAH.	Norepinephrine	84-97	C-X-C motif chemokine ligand 8	Canis lupus familiaris	28-32
19223155-7	2009	According to our results, the higher serotonergic symptom score and cord blood DHPG concentration in rapid MAO-A metabolizers suggest that norepinephrine may modify the severity of perinatal serotonergic symptoms.	Norepinephrine	139-153	monoamine oxidase A	Homo sapiens	107-112
19293728-2	2009	Our previous study showed that the stimulatory effect of norepinephrine on VSMC proliferation is inhibited by D1-like receptors and the D3 dopamine receptor, a member of the D2-like receptor family.	Norepinephrine	57-71	dopamine receptor D3	Homo sapiens	136-156
19326052-6	2009	Finally, confounding variables on dPP measurements, such as ventilation parameters, pneumoperitoneum and use of norepinephrine are also mentioned.	Norepinephrine	112-126	decapentaplegic	Drosophila melanogaster	34-37
19046799-2	2009	The aim of this study was to relate psychiatric distress, as expressed by the scores in the SCL-90 subscales, to CSF levels of the main metabolites of noradrenaline (MHPG), serotonin (5-HIAA), and dopamine (HVA) in NPH patients.	Norepinephrine	151-164	colony stimulating factor 2	Homo sapiens	113-116
19212675-2	2009	By microarray expression analysis (Affymetrix HU133A) important players in the noradrenalin biosynthesis pathway (DBH, DDC, GATA2, GATA3, PHOX2A, PHOX2B, SLC6A2 SLC18A1 and TH) were found to be among the top ranked genes in showing lower expression in unfavorable NB tumor types as compared to favorable ones.	Norepinephrine	79-91	dopamine beta-hydroxylase	Homo sapiens	114-117
19178946-8	2009	DBH catalyses the hydroxylation of the important neurotransmitter dopamine into norepinephrine in the presence of both molecular oxygen and a reducing co-substrate.	Norepinephrine	80-94	dopamine beta-hydroxylase	Homo sapiens	0-3
19190523-3	2009	However, it was found that the widely used 5-HT receptor antagonists NAN-190 (5-HT1A) and SB 269970 (5-HT7) both blocked alpha2-adrenoceptors, and hence depressed inhibitory synaptic potentials and hyperpolarizations evoked by noradrenaline, in these neurons.	Norepinephrine	227-240	5-hydroxytryptamine receptor 1A	Cavia porcellus	78-84
18982239-1	2009	Dopamine-beta-hydroxylase (DbetaH) catalyzes the conversion of dopamine to norepinephrine in central noradrenergic and adrenergic neurons and thus is critically involved in the biosynthesis of catecholamines.	Norepinephrine	75-89	dopamine beta-hydroxylase	Homo sapiens	0-25
19076268-9	2009	These studies provide the first direct evidence for functional, nongenomic actions of TH leading to rapid changes in neuronal excitability in adult rat DG studied in vivo and highlight the opposing effects of T4 and T3 on norepinephrine-induced responses of CA1 cells studied in vitro.	Norepinephrine	222-236	carbonic anhydrase 1	Rattus norvegicus	258-261
19343315-9	2009	Conversely, the inhibition of endogeneous miR-338 levels in the axon significantly increased mitochondrial activity and norepinephrine uptake into the axon.	Norepinephrine	120-134	microRNA 338	Homo sapiens	42-49
18930727-0	2008	Neurokinin-1 receptor antagonists modulate brain noradrenaline and serotonin interactions.	Norepinephrine	49-62	tachykinin receptor 1	Rattus norvegicus	0-21
18768761-6	2008	Furthermore, norepinephrine and forskolin were able to synchronize circadian rhythms in bmal1.	Norepinephrine	13-27	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	88-93
18762182-3	2008	Dexamethasone and norepinephrine administered separately oppositely affected differentiation of human neuroblastoma SH-SY5Y cells, observed by both morphological alterations and gene expression, at the level of mRNA and protein of the differentiation markers Gap-43, L1 and laminin.	Norepinephrine	18-32	growth associated protein 43	Homo sapiens	259-265
18361446-1	2008	Monoamine oxidase A (MAOA) is an enzyme expressed in the brain that metabolizes dopamine, norepinephrine, epinephrine, and serotonin.	Norepinephrine	90-104	monoamine oxidase A	Homo sapiens	0-19
18361446-1	2008	Monoamine oxidase A (MAOA) is an enzyme expressed in the brain that metabolizes dopamine, norepinephrine, epinephrine, and serotonin.	Norepinephrine	90-104	monoamine oxidase A	Homo sapiens	21-25
18840973-2	2008	They include transporters for norepinephrine, dopamine and serotonin, which are encoded by the SLC6A2, SLC6A3, and SLC6A4 genes, respectivily.	Norepinephrine	30-44	solute carrier family 6 member 3	Canis lupus familiaris	103-109
18338249-3	2008	GATA-3 robustly transactivates the promoter function of the noradrenaline (NA)-synthesizing DBH gene, via two specific upstream promoter domains; one at -62 to -32 bp and the other at -891 to -853 bp.	Norepinephrine	60-73	dopamine beta-hydroxylase	Homo sapiens	92-95
18572378-2	2008	Their spatial and temporal expression at the neural crest is instrumental in determining neuronal precursor fate, and by regulating DbetaH expression, the enzyme catalysing noradrenaline synthesis from dopamine, they also play a role in determination of noradrenergic phenotype.	Norepinephrine	173-186	dopamine beta-hydroxylase	Homo sapiens	132-138
18567701-0	2008	Phospholipase C-delta1 modulates sustained contraction of rat mesenteric small arteries in response to noradrenaline, but not endothelin-1.	Norepinephrine	103-116	phospholipase C, delta 1	Rattus norvegicus	0-22
18567701-2	2008	Our aim was to investigate whether PLC-delta(1), a PLC isoform implicated in alpha(1)-adrenoreceptor signaling and the pathogenesis of hypertension, is involved in noradrenaline (NA) or endothelin (ET-1)-induced PIP(2) hydrolysis and contraction.	Norepinephrine	164-177	phospholipase C, delta 1	Rattus norvegicus	35-47
18648551-8	2008	PC12 cell production of norepinephrine and dopamine was significantly blunted following exposure to recombinant rat C5a in a time-dependent and dose-dependent manner.	Norepinephrine	24-38	complement C5	Rattus norvegicus	116-119
18397915-1	2008	In female rodents, hypothalamic norepinephrine (NE) has a role in stimulating the secretion of gonadotropin-releasing hormone (GnRH) that triggers the ovulatory surge of luteinizing hormone (LH).	Norepinephrine	32-46	gonadotropin releasing hormone 1	Rattus norvegicus	95-125
18397915-1	2008	In female rodents, hypothalamic norepinephrine (NE) has a role in stimulating the secretion of gonadotropin-releasing hormone (GnRH) that triggers the ovulatory surge of luteinizing hormone (LH).	Norepinephrine	32-46	gonadotropin releasing hormone 1	Rattus norvegicus	127-131
20641420-2	2004	MAO-A preferentially oxidizes serotonin and noradrenaline, whereas MAO-B preferentially oxidizes phenethylamine.	Norepinephrine	44-57	monoamine oxidase A	Homo sapiens	0-5
18177483-0	2008	Chronic noradrenaline increases renal expression of NHE-3, NBC-1, BSC-1 and aquaporin-2.	Norepinephrine	8-21	aquaporin 2	Rattus norvegicus	76-87
18177483-13	2008	We conclude that noradrenaline-induced increases in the expression of NHE-3, NBC-1, BSC-1 and aquaporin-2 are likely to play an important role in the regulation of salt and water transport by noradrenaline in the kidney and may explain, at least in part, the altered renal sodium and water handling associated with overactivation of the sympathetic system.	Norepinephrine	17-30	aquaporin 2	Rattus norvegicus	94-105
18194185-9	2008	In CC strips precontracted with norepinephrine, histamine, and endothelin-1, both ClC blockers significantly reversed the tone.	Norepinephrine	32-46	cystic fibrosis transmembrane conductance regulator	Oryctolagus cuniculus	82-85
18388730-1	2008	Monoamine oxidase A (MAOA) enzymatically degrades biogenic amines such as norepinephrine, dopamine, and serotonin, and plays a key role in the regulation of their neurotransmission.	Norepinephrine	74-88	monoamine oxidase A	Homo sapiens	0-19
18388730-1	2008	Monoamine oxidase A (MAOA) enzymatically degrades biogenic amines such as norepinephrine, dopamine, and serotonin, and plays a key role in the regulation of their neurotransmission.	Norepinephrine	74-88	monoamine oxidase A	Homo sapiens	21-25
18193048-1	2008	Morphine, a powerful analgesic, and norepinephrine, the principal neurotransmitter of sympathetic nerves, exert major inhibitory effects on both peripheral and brain neurons by activating distinct cell-surface G protein-coupled receptors-the mu-opioid receptor (MOR) and alpha2A-adrenergic receptor (alpha2A-AR), respectively.	Norepinephrine	36-50	opioid receptor mu 1	Homo sapiens	242-260
18193048-1	2008	Morphine, a powerful analgesic, and norepinephrine, the principal neurotransmitter of sympathetic nerves, exert major inhibitory effects on both peripheral and brain neurons by activating distinct cell-surface G protein-coupled receptors-the mu-opioid receptor (MOR) and alpha2A-adrenergic receptor (alpha2A-AR), respectively.	Norepinephrine	36-50	opioid receptor mu 1	Homo sapiens	262-265
18193048-4	2008	We discovered that morphine binding to the MOR triggers a conformational change in the norepinephrine-occupied alpha2A-AR that inhibits its signaling to G(i) and the downstream MAP kinase cascade.	Norepinephrine	87-101	opioid receptor mu 1	Homo sapiens	43-46
18063000-9	2008	In conclusion, inhibitory P2Y and facilitatory P2X1-like receptors, involved in the regulation of glutamate (P2Y13 and/or P2Y1) and noradrenaline (P2Y13 and/or P2Y1, P2Y12) release have been identified, which provide novel target sites for analgesics acting at the spinal cord level.	Norepinephrine	132-145	purinergic receptor P2Y12	Rattus norvegicus	166-171
18173840-3	2008	Dopamine-beta hydroxylase (DbH) catalyzes the conversion of dopamine to norepinephrine and could, therefore, have an influence on both cocaine action and the basal sensitivity of neurotransmitter systems to cocaine.	Norepinephrine	72-86	dopamine beta-hydroxylase	Homo sapiens	0-25
18173840-3	2008	Dopamine-beta hydroxylase (DbH) catalyzes the conversion of dopamine to norepinephrine and could, therefore, have an influence on both cocaine action and the basal sensitivity of neurotransmitter systems to cocaine.	Norepinephrine	72-86	dopamine beta-hydroxylase	Homo sapiens	27-30
17074321-8	2007	Decreased expression of DBH with age in the retina could lead to reduced production of norepinephrine, potentially resulting in an increase of beta1-adrenergic receptor expression due to denervation supersensitivity.	Norepinephrine	87-101	dopamine beta-hydroxylase	Rattus norvegicus	24-27
17012607-4	2007	Activation of UCP3 is indirectly regulated by norepinephrine (NE) and is dependent upon the availability of free fatty acids (FFAs).	Norepinephrine	46-60	uncoupling protein 3	Rattus norvegicus	14-18
17365979-1	2007	PURPOSE: To elucidate differential functional and phenotypic changes in response to relevant catecholamines, the generation of oxidative free radicals by PMN, and changes in the expression of L-selectin and Mac-1 on the surface of PMN were examined in the presence of epinephrine, norepinephrine and dopamine in physiological and pharmacological concentrations.	Norepinephrine	281-295	selectin L	Homo sapiens	192-202
17229089-2	2006	We thus tested in rats the effect of pharmacological depletion of noradrenaline with the noradrenergic toxin DSP4 (5 mg/kg) on the expression of the TJ proteins zonula occludens-1 (ZO1) and occludin.	Norepinephrine	66-79	tight junction protein 1	Rattus norvegicus	161-179
17229089-2	2006	We thus tested in rats the effect of pharmacological depletion of noradrenaline with the noradrenergic toxin DSP4 (5 mg/kg) on the expression of the TJ proteins zonula occludens-1 (ZO1) and occludin.	Norepinephrine	66-79	tight junction protein 1	Rattus norvegicus	181-184
17356229-1	2006	Phenylethanolamine N-methyltransferase (PNMT) is a final enzyme in catecholamine synthesizing cascade that converts noradrenaline to adrenaline.	Norepinephrine	116-129	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-38
17356229-1	2006	Phenylethanolamine N-methyltransferase (PNMT) is a final enzyme in catecholamine synthesizing cascade that converts noradrenaline to adrenaline.	Norepinephrine	116-129	phenylethanolamine-N-methyltransferase	Rattus norvegicus	40-44
17103145-4	2006	The contractions to 5-HT were competitively antagonized by the 5-HT(2A) receptor antagonist ketanserin, whilst those to noradrenaline were antagonized by alpha(1)-(prazosin), alpha(2)-(rauwolscine and yohimbine) and alpha(2C/2B)-(OPC-28326) adrenoceptor antagonists.	Norepinephrine	120-133	adrenoceptor alpha 1D	Homo sapiens	154-162
17175506-1	2006	Phenylethanolamine N-methyltransferase (PNMT) is the final enzyme in the catecholamine synthesizing cascade that converts noradrenaline (NA) to adrenaline (Adr).	Norepinephrine	122-135	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-38
17175506-1	2006	Phenylethanolamine N-methyltransferase (PNMT) is the final enzyme in the catecholamine synthesizing cascade that converts noradrenaline (NA) to adrenaline (Adr).	Norepinephrine	122-135	phenylethanolamine-N-methyltransferase	Rattus norvegicus	40-44
16876143-1	2006	BACKGROUND: Dopamine beta hydroxylase (DbetaH) catalyzes the conversion of dopamine to noradrenaline.	Norepinephrine	87-100	dopamine beta-hydroxylase	Homo sapiens	12-37
16896926-1	2006	Monoamine oxidase A (MAOA) catalyses the oxidative deamination of biogenic amines including neurotransmitters, mainly norepinephrine and serotonin in the brain and peripheral tissues.	Norepinephrine	118-132	monoamine oxidase A	Homo sapiens	0-19
16896926-1	2006	Monoamine oxidase A (MAOA) catalyses the oxidative deamination of biogenic amines including neurotransmitters, mainly norepinephrine and serotonin in the brain and peripheral tissues.	Norepinephrine	118-132	monoamine oxidase A	Homo sapiens	21-25
17030082-5	2006	In the spinal cord, norepinephrine released from descending pathways suppresses pain by inhibitory action on alpha-2A-adrenoceptors on central terminals of primary afferent nociceptors (presynaptic inhibition), by direct alpha-2-adrenergic action on pain-relay neurons (postsynaptic inhibition), and by alpha-1-adrenoceptor-mediated activation of inhibitory interneurons.	Norepinephrine	20-34	adrenoceptor alpha 1D	Homo sapiens	303-310
16814247-1	2006	Noradrenaline signals the initiation of brown fat thermogenesis and the fatty acids liberated by the hormone-stimulated lipolysis act as second messengers to activate the uncoupling protein UCP1.	Norepinephrine	0-13	uncoupling protein 1	Homo sapiens	190-194
16735605-1	2006	Nicotine"s modulation of hippocampal noradrenergic neurotransmission may contribute to its mnemonic properties, but the nicotinic acetylcholine receptor (nAChR) subtypes that modulate terminal release of norepinephrine are unknown.	Norepinephrine	204-218	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	154-159
17131588-5	2006	DBH encodes the enzyme that converts dopamine to noradrenaline and is crucial to catecholamine regulation.	Norepinephrine	49-62	dopamine beta-hydroxylase	Homo sapiens	0-3
16728402-1	2006	Monoamine oxidase (MAO) A is a key enzyme for the degradation of neurotransmitters serotonin, norepinephrine, and dopamine.	Norepinephrine	94-108	monoamine oxidase A	Homo sapiens	0-25
16252068-1	2006	As the enzyme dopamine-beta-hydroxylase (DbetaH) converts dopamine to norepinephrine and both transmitters seem to be involved in the pathology of alcoholism and severe alcohol withdrawal symptoms, the gene encoding DbetaH (DBH) was applied to explore the genetic background of alcoholism and severe withdrawal symptoms.	Norepinephrine	70-84	dopamine beta-hydroxylase	Homo sapiens	14-39
16805813-0	2006	Cannabinoids attenuate norepinephrine-induced melatonin biosynthesis in the rat pineal gland by reducing arylalkylamine N-acetyltransferase activity without involvement of cannabinoid receptors.	Norepinephrine	23-37	aralkylamine N-acetyltransferase	Rattus norvegicus	105-139
16805813-4	2006	We demonstrated that treatment of cultured rat pineals with 9-carboxy-11-nor-delta-9-tetrahydrocannabinol (THC), cannabidiol or cannabinol significantly reduced norepinephrine-induced arylalkylamine N-acetyltransferase (AANAT) activity and melatonin biosynthesis.	Norepinephrine	161-175	aralkylamine N-acetyltransferase	Rattus norvegicus	184-218
16805813-4	2006	We demonstrated that treatment of cultured rat pineals with 9-carboxy-11-nor-delta-9-tetrahydrocannabinol (THC), cannabidiol or cannabinol significantly reduced norepinephrine-induced arylalkylamine N-acetyltransferase (AANAT) activity and melatonin biosynthesis.	Norepinephrine	161-175	aralkylamine N-acetyltransferase	Rattus norvegicus	220-225
16569708-2	2006	Although inactive in itself, the neuropeptide corticotropin releasing factor (CRF) strongly amplified the effect of BDNF, increasing the number of cells expressing TH and the active accumulation of noradrenaline by a factor of 2 to 3 via a mechanism that was nonmitogenic.	Norepinephrine	198-211	corticotropin releasing hormone	Homo sapiens	46-76
16730340-10	2006	They also suggest that the PDE4D subtype may be of particular importance as an antidepressant target in that it is regulated by repeated treatment with both norepinephrine and serotonin reuptake inhibitors as well as by the PDE4 inhibitor rolipram, drugs that produce antidepressant effects via different neuropharmacological mechanisms.	Norepinephrine	157-171	phosphodiesterase 4D, cAMP specific	Mus musculus	27-32
16574904-3	2006	Here we show that contraction of intact mouse tail arteries induced with 42 mmol/L KCl or 0.5 micromol/L noradrenaline was associated with a approximately 2-fold increase in the phosphorylation of the regulatory subunit of myosin phosphatase (SMPP-1M), MYPT1, at Thr696, which was reversed in arteries relaxed with urocortin.	Norepinephrine	105-118	protein phosphatase 1, regulatory subunit 12A	Mus musculus	253-258
16648270-8	2006	The stimulation of I(Ca,L) in response to beta(2)-AR activation was eliminated by disruption of caveolae with 10 mM methyl beta-cyclodextrin or by small interfering RNA directed against caveolin-3, whereas beta(1)-AR stimulation (norepinephrine plus prazosin) of I(Ca,L) was not altered.	Norepinephrine	230-244	adrenergic receptor, beta 2	Mus musculus	42-52
16612252-9	2006	By contrast, NPY acted less specifically, blocking norepinephrine release triggered by either nicotine or membrane depolarization.	Norepinephrine	51-65	neuropeptide Y	Homo sapiens	13-16
16269576-8	2006	Urinary norepinephrine and epinephrine excretion was higher in RGS2(-/-) than in RGS2(+/+) mice.	Norepinephrine	8-22	regulator of G-protein signaling 2	Mus musculus	63-67
16364652-1	2006	The histamine H3 receptor subtype negatively modulates the release of various neurotransmitters such as histamine, glutamate, norepinephrine, acetylcholine and many others mainly in the CNS and H3 antagonists have been developed to treat central diseases characterized by neurotransmission disturbance such as schizophrenia, memory/learning and sleep disorders.	Norepinephrine	126-140	histamine receptor H3	Homo sapiens	4-25
16202396-2	2006	The monoamine oxidase-A (MAO-A) gene, coding for an enzyme primarily involved in serotonin and noradrenaline catabolism, presents a well-characterized functional polymorphism consisting of a variable number of tandem repeats in the promoter region, with high-activity and low-activity variants.	Norepinephrine	95-108	monoamine oxidase A	Homo sapiens	4-23
16202396-2	2006	The monoamine oxidase-A (MAO-A) gene, coding for an enzyme primarily involved in serotonin and noradrenaline catabolism, presents a well-characterized functional polymorphism consisting of a variable number of tandem repeats in the promoter region, with high-activity and low-activity variants.	Norepinephrine	95-108	monoamine oxidase A	Homo sapiens	25-30
16451083-1	2006	A novel series of dopamine beta-hydroxylase (DBH) inhibitors was designed and synthesized incorporating modifications to the core structure of nepicastat 3, with the principal aim of discovering potent DBH inhibitors exerting minimal effects on dopamine (DA) and noradrenaline (NA) levels in the central nervous system.	Norepinephrine	263-276	dopamine beta-hydroxylase	Rattus norvegicus	45-48
17017570-1	2006	In the 1950s it was found that an artificial aminoacid, 3,4-threo-dihydroxyphenylserine (DOPS), was converted to norepinephrine (NE) in a single step by the enzyme L-aromatic amino acid decarboxylase (AADC), bypassing the need for the rate limiting enzyme dopamine beta hydroxylase.	Norepinephrine	113-127	dopamine beta-hydroxylase	Homo sapiens	256-281
17447416-1	2006	Monoamine oxidases A and B (MAO A and MAO B) are the major enzymes that catalyze the oxidative deamination of monoamine neurotaransmitters such as dopamine (DA), noradrenaline, and serotonin in the central and peripheral nervous systems.	Norepinephrine	162-175	monoamine oxidase A	Homo sapiens	0-26
17447416-1	2006	Monoamine oxidases A and B (MAO A and MAO B) are the major enzymes that catalyze the oxidative deamination of monoamine neurotaransmitters such as dopamine (DA), noradrenaline, and serotonin in the central and peripheral nervous systems.	Norepinephrine	162-175	monoamine oxidase A	Homo sapiens	28-43
16354910-0	2005	Mecp2 deficiency disrupts norepinephrine and respiratory systems in mice.	Norepinephrine	26-40	methyl CpG binding protein 2	Mus musculus	0-5
16099857-2	2005	Addition of c-lact or MG132 3 h after norepinephrine (NE) stimulation produced a significant increase in AA-NAT protein level and enzyme activity.	Norepinephrine	38-52	aralkylamine N-acetyltransferase	Rattus norvegicus	105-111
16307583-2	2005	In Phox2a mutant mice, which do not express A6 neurons, we previously hypothesized that the release of endogenous norepinephrine by A6 neurons is required for a normal respiratory rhythm to occur at birth.	Norepinephrine	114-128	paired-like homeobox 2a	Mus musculus	3-9
16358231-4	2005	On univariate analysis, UTN was inversely related to heart rate (r=-0.24), dialysis treatment duration (r=-0.27), norepinephrine (r=-0.28), neuropeptide Y (NPY) (r=-0.66), brain natriuretic peptide (BNP) (r=-0.41) and atrial natriuretic peptide (ANP) (r=-0.28) (all p&lt;0.008).	Norepinephrine	114-128	urotensin 2	Homo sapiens	24-27
16040158-1	2005	In the prostatic portion of rat vas deferens, activation of adenosine A 2B-receptors, beta2-adrenoceptors, adenylyl cyclase or protein kinase A caused a facilitation of noradrenaline release.	Norepinephrine	169-182	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	127-143
16226229-1	2005	In vitro experiments show norepinephrine activates glycogen phosphorylase and glycogenolysis in forebrain glia.	Norepinephrine	26-40	glycogen phosphorylase L	Rattus norvegicus	51-73
16210796-1	2005	Dopamine and noradrenaline are catecholamine neurotransmitters that are produced by biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine beta -hydroxylase (DBH).	Norepinephrine	13-26	tyrosine hydroxylase	Canis lupus familiaris	113-133
16210796-1	2005	Dopamine and noradrenaline are catecholamine neurotransmitters that are produced by biosynthetic enzymes such as tyrosine hydroxylase (TH) and dopamine beta -hydroxylase (DBH).	Norepinephrine	13-26	tyrosine hydroxylase	Canis lupus familiaris	135-137
16079262-2	2005	The contractile response to noradrenaline (NA) in organ-cultured diabetic rat aortae cultured with insulin or IGF-I was significantly greater than the corresponding responses in (a) diabetic rat aortae cultured in serum-free medium and (b) control rat aortae cultured with insulin or IGF-I.	Norepinephrine	28-41	insulin-like growth factor 1	Rattus norvegicus	110-115
16079262-2	2005	The contractile response to noradrenaline (NA) in organ-cultured diabetic rat aortae cultured with insulin or IGF-I was significantly greater than the corresponding responses in (a) diabetic rat aortae cultured in serum-free medium and (b) control rat aortae cultured with insulin or IGF-I.	Norepinephrine	28-41	insulin-like growth factor 1	Rattus norvegicus	284-289
15762841-8	2005	In primary brown adipocytes from C/EBPbeta(-/-) mice, induction of gene expression by noradrenaline was preserved.	Norepinephrine	86-99	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	33-42
15647328-1	2005	Using a guinea pig heart synaptosomal preparation, we previously observed that norepinephrine (NE) exocytosis was attenuated by a blockade of P2X purinoceptors, potentiated by inhibition of ectonucleoside triphosphate diphosphohydrolase-1 (E-NTPDase1)/CD39, and reduced by soluble CD39, a recombinant form of human E-NTPDase1/CD39.	Norepinephrine	79-93	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	281-285
15647328-1	2005	Using a guinea pig heart synaptosomal preparation, we previously observed that norepinephrine (NE) exocytosis was attenuated by a blockade of P2X purinoceptors, potentiated by inhibition of ectonucleoside triphosphate diphosphohydrolase-1 (E-NTPDase1)/CD39, and reduced by soluble CD39, a recombinant form of human E-NTPDase1/CD39.	Norepinephrine	79-93	ectonucleoside triphosphate diphosphohydrolase 1	Cavia porcellus	315-325
15647328-1	2005	Using a guinea pig heart synaptosomal preparation, we previously observed that norepinephrine (NE) exocytosis was attenuated by a blockade of P2X purinoceptors, potentiated by inhibition of ectonucleoside triphosphate diphosphohydrolase-1 (E-NTPDase1)/CD39, and reduced by soluble CD39, a recombinant form of human E-NTPDase1/CD39.	Norepinephrine	79-93	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	281-285
15647328-2	2005	This suggests that norepinephrine and ATP are coreleased upon depolarization of cardiac sympathetic nerve endings and that ATP enhances norepinephrine exocytosis by an action modulated by E-NTPDase1/CD39 activity.	Norepinephrine	19-33	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	199-203
15647328-2	2005	This suggests that norepinephrine and ATP are coreleased upon depolarization of cardiac sympathetic nerve endings and that ATP enhances norepinephrine exocytosis by an action modulated by E-NTPDase1/CD39 activity.	Norepinephrine	136-150	ectonucleoside triphosphate diphosphohydrolase 1	Cavia porcellus	188-198
15647328-2	2005	This suggests that norepinephrine and ATP are coreleased upon depolarization of cardiac sympathetic nerve endings and that ATP enhances norepinephrine exocytosis by an action modulated by E-NTPDase1/CD39 activity.	Norepinephrine	136-150	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	199-203
15647328-4	2005	We report that E-NTPDase1/CD39 is selectively localized in human and porcine cardiac neurons and that depolarization of porcine heart tissue elicits omega-conotoxin-inhibitable release of both norepinephrine and ATP.	Norepinephrine	193-207	ectonucleoside triphosphate diphosphohydrolase 1	Cavia porcellus	15-25
15647328-4	2005	We report that E-NTPDase1/CD39 is selectively localized in human and porcine cardiac neurons and that depolarization of porcine heart tissue elicits omega-conotoxin-inhibitable release of both norepinephrine and ATP.	Norepinephrine	193-207	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	26-30
15869489-0	2005	A role for norepinephrine in the regulation of context-dependent ZENK expression in male zebra finches (Taeniopygia guttata).	Norepinephrine	11-25	early growth response protein 1	Taeniopygia guttata	65-69
15814105-3	2005	Here, we have used in vivo microdialysis to compare the concentrations of extracellular noradrenaline ("efflux") in the cerebral cortex of anaesthetised NK1-/- and NK1+/+ mice.	Norepinephrine	88-101	tachykinin 1	Mus musculus	153-156
15814105-6	2005	Basal noradrenaline efflux was increased 2 to 4-fold in NK1-/- mice compared with NK1+/+ mice but there was no difference in the effects of desipramine.	Norepinephrine	6-19	tachykinin 1	Mus musculus	56-59
16097364-1	2005	Dopamine-beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine and is released from sympathetic neurons into the circulation.	Norepinephrine	72-86	dopamine beta-hydroxylase	Homo sapiens	0-25
16097364-1	2005	Dopamine-beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine and is released from sympathetic neurons into the circulation.	Norepinephrine	72-86	dopamine beta-hydroxylase	Homo sapiens	27-30
15715653-7	2005	The neuroprotective action of norepinephrine can be explained by (1) its ability to form complexes with Fe3+, (2) the uptake of Fe-norepinephrine complex via the norepinephrine transporter and (3) lack of toxicity of the Fe-norepinephrine complex even when DT-diaphorase is inhibited.	Norepinephrine	30-44	solute carrier family 6 member 2	Rattus norvegicus	162-188
15494609-7	2005	Remarkably, mRNA for phenylethanolamine N-methyltransferase (PNMT), which converts norepinephrine to epinephrine, was reduced (P &lt; 0.05 vs. all) 40% only in D-hypo rats.	Norepinephrine	83-97	phenylethanolamine-N-methyltransferase	Rattus norvegicus	21-59
15494609-7	2005	Remarkably, mRNA for phenylethanolamine N-methyltransferase (PNMT), which converts norepinephrine to epinephrine, was reduced (P &lt; 0.05 vs. all) 40% only in D-hypo rats.	Norepinephrine	83-97	phenylethanolamine-N-methyltransferase	Rattus norvegicus	61-65
15561429-1	2005	The norepinephrine transporter (NET) plays a major role in regulating the actions of norepinephrine by removing norepinephrine from the synapse.	Norepinephrine	85-99	solute carrier family 6 member 2	Rattus norvegicus	4-30
15358679-0	2004	Norepinephrine induction of mitogen-activated protein kinase phosphatase-1 expression in rat pinealocytes: distinct roles of alpha- and beta-adrenergic receptors.	Norepinephrine	0-14	dual specificity phosphatase 1	Rattus norvegicus	28-74
15358679-1	2004	In this study, we investigated the mechanisms through which norepinephrine (NE) regulates MAPK phosphatase-1 (MKP-1) expression in rat pinealocytes.	Norepinephrine	60-74	dual specificity phosphatase 1	Rattus norvegicus	90-108
15358679-1	2004	In this study, we investigated the mechanisms through which norepinephrine (NE) regulates MAPK phosphatase-1 (MKP-1) expression in rat pinealocytes.	Norepinephrine	60-74	dual specificity phosphatase 1	Rattus norvegicus	110-115
15564894-1	2004	Monoamine oxidase A (MAOA) has been suggested to be involved in human behaviour and physiology due to its key role in the metabolism of several different biological amines including the neurotransmitters serotonin, norepinephrin and dopamine.Recently, a 30 bp repeat in the MAOA gene promoter (uMAOA) has been demonstrated to be polymorphic and to affect transcriptional activity.	Norepinephrine	215-228	monoamine oxidase A	Homo sapiens	0-19
15564894-1	2004	Monoamine oxidase A (MAOA) has been suggested to be involved in human behaviour and physiology due to its key role in the metabolism of several different biological amines including the neurotransmitters serotonin, norepinephrin and dopamine.Recently, a 30 bp repeat in the MAOA gene promoter (uMAOA) has been demonstrated to be polymorphic and to affect transcriptional activity.	Norepinephrine	215-228	monoamine oxidase A	Homo sapiens	21-25
15500961-8	2004	Epinephrine, norepinephrine and octopamine also weakly inhibited macroscopic currents at NR1/NR2A and NR1/NR2B receptors.	Norepinephrine	13-27	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	89-92
15500961-8	2004	Epinephrine, norepinephrine and octopamine also weakly inhibited macroscopic currents at NR1/NR2A and NR1/NR2B receptors.	Norepinephrine	13-27	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	102-105
15500961-8	2004	Epinephrine, norepinephrine and octopamine also weakly inhibited macroscopic currents at NR1/NR2A and NR1/NR2B receptors.	Norepinephrine	13-27	glutamate receptor ionotropic, NMDA 2B	Xenopus laevis	106-110
15500541-0	2004	Interaction between norepinephrine, oxytocin, and nitric oxide in the stimulation of gonadotropin-releasing hormone release from proestrous rat basal hypothalamus explants.	Norepinephrine	20-34	gonadotropin releasing hormone 1	Rattus norvegicus	85-115
15500541-1	2004	In the proestrous female rat, norepinephrine, oxytocin and nitric oxide (NO) all participate in the regulation of the preovulatory gonadotropin-releasing hormone (GnRH) surge.	Norepinephrine	30-44	gonadotropin releasing hormone 1	Rattus norvegicus	131-161
15500541-1	2004	In the proestrous female rat, norepinephrine, oxytocin and nitric oxide (NO) all participate in the regulation of the preovulatory gonadotropin-releasing hormone (GnRH) surge.	Norepinephrine	30-44	gonadotropin releasing hormone 1	Rattus norvegicus	163-167
15500541-3	2004	The present studies were undertaken to determine whether norepinephrine could also stimulate GnRH release from similar explants, to identify the receptors responsible for this effect and to investigate interactions between norepinephrine, oxytocin and NO.	Norepinephrine	57-71	gonadotropin releasing hormone 1	Rattus norvegicus	93-97
15500541-4	2004	Norepinephrine significantly stimulated GnRH release from proestrous basal hypothalamus explants, and coadministration of the alpha(1)-adrenergic antagonist prazosin blocked this effect.	Norepinephrine	0-14	gonadotropin releasing hormone 1	Rattus norvegicus	40-44
15500541-5	2004	Combined administration of oxytocin and norepinephrine stimulated significantly more GnRH release than either drug alone, and this stimulation was blocked by inhibition of NO synthase, or by an oxytocin receptor antagonist.	Norepinephrine	40-54	gonadotropin releasing hormone 1	Rattus norvegicus	85-89
15500541-9	2004	These results demonstrate for the first time that oxytocin and norepinephrine dramatically stimulate GnRH release from basal hypothalamus explants harvested on the afternoon of proestrus, and indicate that this involves oxytocin receptor and NO-dependent mechanisms.	Norepinephrine	63-77	gonadotropin releasing hormone 1	Rattus norvegicus	101-105
15306230-6	2004	CONCLUSIONS: In rat tail artery, the A(2A) receptor-mediated facilitation of noradrenaline release requires activation of both PKC and PKA, and PKA activation seems to occur downstream of PKC activation.	Norepinephrine	77-90	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	135-138
15242772-2	2004	Utilizing a three-dimensional (3D) collagen assay and computer-assisted, continuous single cell tracking, we investigated the basic parameters for both the spontaneous and norepinephrine-induced migration of highly metastatic MBA-MB-468 breast, PC-3 prostate, and SW 480 colon carcinoma cells.	Norepinephrine	172-186	chromobox 8	Homo sapiens	245-249
15213629-12	2004	CONCLUSIONS: Depletion of norepinephrine attenuated burn and burn sepsis-induced bone marrow progenitor clonal growth in response to macrophage- and granulocyte-macrophage colony-stimulating factor.	Norepinephrine	26-40	colony stimulating factor 2	Homo sapiens	133-197
15240349-0	2004	Brain circuits involved in corticotropin-releasing factor-norepinephrine interactions during stress.	Norepinephrine	58-72	corticotropin releasing hormone	Homo sapiens	27-57
15020588-9	2004	With aortic rings (without endothelium) preconstricted by high K(+) saline or by the alpha-adrenergic agonist norepinephrine, CFTR activators produced a concentration-dependent relaxation.	Norepinephrine	110-124	CF transmembrane conductance regulator	Rattus norvegicus	126-130
15113605-1	2004	Norepinephrine transporter (NET) mediates the active removal of norepinephrine (NE) released from sympathetic nerve terminals via reuptake, and NET function and expression can be regulated by cocaine.	Norepinephrine	64-78	solute carrier family 6 member 2	Rattus norvegicus	0-26
15113605-1	2004	Norepinephrine transporter (NET) mediates the active removal of norepinephrine (NE) released from sympathetic nerve terminals via reuptake, and NET function and expression can be regulated by cocaine.	Norepinephrine	64-78	solute carrier family 6 member 2	Rattus norvegicus	28-31
15044095-1	2004	Conversion of neurotransmitter dopamine into norepinephrine is catalyzed by dopamine beta-hydroxylase (DbH).	Norepinephrine	45-59	dopamine beta-hydroxylase	Homo sapiens	76-101
15044095-1	2004	Conversion of neurotransmitter dopamine into norepinephrine is catalyzed by dopamine beta-hydroxylase (DbH).	Norepinephrine	45-59	dopamine beta-hydroxylase	Homo sapiens	103-106
15067320-6	2004	NGF expression, cardiac sympathetic innervation, and norepinephrine concentration were specifically reduced in endothelin-1-deficient mouse hearts, but not in angiotensinogen-deficient mice.	Norepinephrine	53-67	endothelin 1	Mus musculus	111-123
14757141-0	2004	Tonic inhibition by orphanin FQ/nociceptin of noradrenaline neurotransmission in the amygdala.	Norepinephrine	46-59	prepronociceptin	Rattus norvegicus	20-31
14757141-0	2004	Tonic inhibition by orphanin FQ/nociceptin of noradrenaline neurotransmission in the amygdala.	Norepinephrine	46-59	prepronociceptin	Rattus norvegicus	32-42
14757141-1	2004	The present microdialysis study investigated whether nociceptin/orphanin FQ exerts a tonic inhibition of the release of noradrenaline in the basolateral nucleus of the amygdala in awake rats.	Norepinephrine	120-133	prepronociceptin	Rattus norvegicus	53-63
14757141-1	2004	The present microdialysis study investigated whether nociceptin/orphanin FQ exerts a tonic inhibition of the release of noradrenaline in the basolateral nucleus of the amygdala in awake rats.	Norepinephrine	120-133	prepronociceptin	Rattus norvegicus	64-75
14757141-5	2004	Local infusion of nociceptin/orphanin FQ (1 microM) itself reduced noradrenaline release in the basolateral nucleus of the amygdala to about 70% of basal levels.	Norepinephrine	67-80	prepronociceptin	Rattus norvegicus	18-28
14757141-5	2004	Local infusion of nociceptin/orphanin FQ (1 microM) itself reduced noradrenaline release in the basolateral nucleus of the amygdala to about 70% of basal levels.	Norepinephrine	67-80	prepronociceptin	Rattus norvegicus	29-40
14757141-6	2004	These results indicate that a large part of basal release of noradrenaline in the basolateral nucleus of the amygdala is under tonic inhibitory control by endogenous nociceptin/orphanin FQ through the N/OFQ peptide receptors localized within the basolateral nucleus of the amygdala.	Norepinephrine	61-74	prepronociceptin	Rattus norvegicus	166-176
14697899-5	2004	The cheese reaction is a consequence of inhibition of MAO-A, the enzyme responsible for metabolism of noradrenaline and serotonin, located in peripheral adrenergic neurons.	Norepinephrine	102-115	monoamine oxidase A	Homo sapiens	54-59
15003356-4	2004	Oxidized NPY, like native NPY, potentiated the noradrenaline and adenosine 5"-triphospahate-induced vasoconstriction, an effect blocked by BIBP 3226 and consonant with the RT-PCR detection of the mRNA encoding the NPY Y1 receptor.	Norepinephrine	47-60	neuropeptide Y	Homo sapiens	9-12
15003356-4	2004	Oxidized NPY, like native NPY, potentiated the noradrenaline and adenosine 5"-triphospahate-induced vasoconstriction, an effect blocked by BIBP 3226 and consonant with the RT-PCR detection of the mRNA encoding the NPY Y1 receptor.	Norepinephrine	47-60	neuropeptide Y	Homo sapiens	26-29
15003356-4	2004	Oxidized NPY, like native NPY, potentiated the noradrenaline and adenosine 5"-triphospahate-induced vasoconstriction, an effect blocked by BIBP 3226 and consonant with the RT-PCR detection of the mRNA encoding the NPY Y1 receptor.	Norepinephrine	47-60	neuropeptide Y	Homo sapiens	26-29
14506227-1	2003	Dopamine beta-hydroxylase (DBH) catalyzes the production of norepinephrine, and its expression defines the noradrenergic phenotype.	Norepinephrine	60-74	dopamine beta-hydroxylase	Homo sapiens	0-25
14506227-1	2003	Dopamine beta-hydroxylase (DBH) catalyzes the production of norepinephrine, and its expression defines the noradrenergic phenotype.	Norepinephrine	60-74	dopamine beta-hydroxylase	Homo sapiens	27-30
12900412-9	2003	The cDNAs tomTHT1-3, tomTHT7-1, and tomTHT7-8 encoded proteins with a high degree of amino acid sequence homology, although the recombinant proteins had different preferences for octopamine and noradrenaline.	Norepinephrine	194-207	N-hydroxycinnamoyl-CoA:tyramine N-hydroxycinnamoyl transferase THT7-1	Solanum lycopersicum	21-30
12842874-4	2003	DBH catalyzes norepinephrine synthesis, and several studies have suggested a role for norepinephrine in ethanol-mediated behaviors.	Norepinephrine	14-28	dopamine beta-hydroxylase	Homo sapiens	0-3
14512028-2	2003	Dopamine-beta-hydroxylase (DBH) is the penultimate enzyme required for synthesis of norepinephrine and is thus a noradrenergic cell type-specific marker.	Norepinephrine	84-98	dopamine beta-hydroxylase	Homo sapiens	0-25
14512028-2	2003	Dopamine-beta-hydroxylase (DBH) is the penultimate enzyme required for synthesis of norepinephrine and is thus a noradrenergic cell type-specific marker.	Norepinephrine	84-98	dopamine beta-hydroxylase	Homo sapiens	27-30
12969236-1	2003	This study evaluated the influence of monoamines, serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline, on differentiating gonadotropin-releasing hormone (GnRH)-producing neurones in foetal mice.	Norepinephrine	92-105	gonadotropin releasing hormone 1	Mus musculus	158-162
12969236-7	2003	These data suggest that an excess of 5-HT and noradrenaline served to accelerate the GnRH neurone migration in Tg8 mice.	Norepinephrine	46-59	gonadotropin releasing hormone 1	Mus musculus	85-89
12969236-8	2003	Moreover, an excess of 5-HT and noradrenaline provided a minor effect on the area and optical density of GnRH neurones (i.e. on GnRH neurone differentiation).	Norepinephrine	32-45	gonadotropin releasing hormone 1	Mus musculus	105-109
12969236-8	2003	Moreover, an excess of 5-HT and noradrenaline provided a minor effect on the area and optical density of GnRH neurones (i.e. on GnRH neurone differentiation).	Norepinephrine	32-45	gonadotropin releasing hormone 1	Mus musculus	128-132
12969236-9	2003	Thus, an excess of 5-HT and noradrenaline appears to inhibit the proliferation of the precursor cells of GnRH neurones and stimulates the GnRH neurone migration to the place of their final location in the septo-preoptic region.	Norepinephrine	28-41	gonadotropin releasing hormone 1	Mus musculus	105-109
12969236-9	2003	Thus, an excess of 5-HT and noradrenaline appears to inhibit the proliferation of the precursor cells of GnRH neurones and stimulates the GnRH neurone migration to the place of their final location in the septo-preoptic region.	Norepinephrine	28-41	gonadotropin releasing hormone 1	Mus musculus	138-142
12960750-2	2003	Dopamine beta-hydroxylase catalyses the conversion of dopamine to norepinephrine in noradrenergic cells.	Norepinephrine	66-80	dopamine beta-hydroxylase	Homo sapiens	0-25
12904944-1	2003	A method to measure catechol- O-methyltransferase (COMT) activity using high performance liquid chromatography-fluorescence detection with norepinephrine (NE) as a natural substrate was optimized for both soluble (S-) and membrane-bound (MB-) COMT activities in rat brain areas, cerebral cortex, cerebellum, hippocampus, brain stem, hypophysis, and hypothalamus.	Norepinephrine	139-153	catechol-O-methyltransferase	Rattus norvegicus	20-49
12904944-1	2003	A method to measure catechol- O-methyltransferase (COMT) activity using high performance liquid chromatography-fluorescence detection with norepinephrine (NE) as a natural substrate was optimized for both soluble (S-) and membrane-bound (MB-) COMT activities in rat brain areas, cerebral cortex, cerebellum, hippocampus, brain stem, hypophysis, and hypothalamus.	Norepinephrine	139-153	catechol-O-methyltransferase	Rattus norvegicus	51-55
12847066-1	2003	BACKGROUND: This study tested the hypothesis that beta1-adrenoreceptor blockade modulates the angiotensin II (Ang II)-evoked neural release of norepinephrine (NE) and epinephrine (Epi) into the cardiac interstitial fluid (ISF) space in experimentally induced mitral regurgitation (MR) in the dog.	Norepinephrine	143-157	adrenoceptor beta 1	Canis lupus familiaris	50-70
12847066-1	2003	BACKGROUND: This study tested the hypothesis that beta1-adrenoreceptor blockade modulates the angiotensin II (Ang II)-evoked neural release of norepinephrine (NE) and epinephrine (Epi) into the cardiac interstitial fluid (ISF) space in experimentally induced mitral regurgitation (MR) in the dog.	Norepinephrine	143-157	ANG	Canis lupus familiaris	110-113
12865408-6	2003	VDU1, but not VDU2, is markedly increased in brown adipocytes by norepinephrine or cold exposure, further amplifying the increase in D2 activity that results from catecholamine-stimulated de novo synthesis.	Norepinephrine	65-79	ubiquitin specific peptidase 33	Homo sapiens	0-4
12736183-1	2003	The effect of cold exposure (4 degrees C) or prolonged norepinephrine infusion on the activity and mRNA levels of glycerokinase (GyK) was investigated in rat interscapular brown adipose tissue (BAT).	Norepinephrine	55-69	glycerol kinase	Rattus norvegicus	114-127
12736183-1	2003	The effect of cold exposure (4 degrees C) or prolonged norepinephrine infusion on the activity and mRNA levels of glycerokinase (GyK) was investigated in rat interscapular brown adipose tissue (BAT).	Norepinephrine	55-69	glycerol kinase	Rattus norvegicus	129-132
12729908-3	2003	We found that noradrenaline transiently induced the expression of mPer1, mPer2, and mE4bp4 1-2 h after alpha(1)-receptor activation.	Norepinephrine	14-27	period circadian clock 1	Mus musculus	66-71
12694379-14	2003	Our laboratory and others have previously reported that NO increased hypothalamic noradrenaline levels, while conversely noradrenaline up-regulated levels of NO synthase, the enzyme responsible for NO formation; and that injection of corticotropin-releasing factor into the brain ventricles releases catecholamines and stimulates NO formation.	Norepinephrine	82-95	corticotropin releasing hormone	Homo sapiens	234-264
12694379-14	2003	Our laboratory and others have previously reported that NO increased hypothalamic noradrenaline levels, while conversely noradrenaline up-regulated levels of NO synthase, the enzyme responsible for NO formation; and that injection of corticotropin-releasing factor into the brain ventricles releases catecholamines and stimulates NO formation.	Norepinephrine	121-134	corticotropin releasing hormone	Homo sapiens	234-264
12679149-4	2003	In vessels from NOS-3 knockout mice, noradrenaline contractions consisted of an early steeply rising phase with a later shallow rising phase to a maximum (10.21+/-0.84 mN), which was significantly greater than in wild-type and NOS-2 knockout mice, and resembled the contraction to phenylephrine (10 microM) in wild-type.	Norepinephrine	37-50	nitric oxide synthase 3, endothelial cell	Mus musculus	16-21
12679149-8	2003	Contractions to noradrenaline in mouse aorta are modulated by NOS-3 and part of the effect involves activation of alpha(2A/D)-adrenoceptors.	Norepinephrine	16-29	nitric oxide synthase 3, endothelial cell	Mus musculus	62-67
12660805-7	2003	These findings reveal that CRH-IR levels are specifically increased in norepinephrine- and serotonin-containing pontine nuclei of depressed suicide men, and thus they are consistent with the hypothesis that CRH neurotransmission is elevated in extra-hypothalamic brain regions of depressed subjects.	Norepinephrine	71-85	corticotropin releasing hormone	Homo sapiens	27-30
12660805-7	2003	These findings reveal that CRH-IR levels are specifically increased in norepinephrine- and serotonin-containing pontine nuclei of depressed suicide men, and thus they are consistent with the hypothesis that CRH neurotransmission is elevated in extra-hypothalamic brain regions of depressed subjects.	Norepinephrine	71-85	corticotropin releasing hormone	Homo sapiens	207-210
12388442-0	2003	Role of nitric oxide and cyclooxygenase-2 in regulating the renal hemodynamic response to norepinephrine.	Norepinephrine	90-104	prostaglandin-endoperoxide synthase 2	Canis lupus familiaris	25-41
12388442-1	2003	We have reported that the renal hemodynamic effects of norepinephrine (NE) are modulated by cyclooxygenase-2 (COX-2)-derived metabolites.	Norepinephrine	55-69	prostaglandin-endoperoxide synthase 2	Canis lupus familiaris	92-108
12388442-1	2003	We have reported that the renal hemodynamic effects of norepinephrine (NE) are modulated by cyclooxygenase-2 (COX-2)-derived metabolites.	Norepinephrine	55-69	prostaglandin-endoperoxide synthase 2	Canis lupus familiaris	110-115
12606256-3	2003	In reserpine-treated rats (97% decrease in endogenous norepinephrine content of the heart), the amplitude of the transient outward current was decreased by 48% and Kv4.2 and Kv4.3 mRNA levels were decreased by 57% and 34%, respectively.	Norepinephrine	54-68	potassium voltage-gated channel subfamily D member 2	Rattus norvegicus	164-169
12522077-0	2003	Pharmacological profiles of presynaptic nociceptin/orphanin FQ receptors modulating 5-hydroxytryptamine and noradrenaline release in the rat neocortex.	Norepinephrine	108-121	prepronociceptin	Rattus norvegicus	40-50
12522077-0	2003	Pharmacological profiles of presynaptic nociceptin/orphanin FQ receptors modulating 5-hydroxytryptamine and noradrenaline release in the rat neocortex.	Norepinephrine	108-121	prepronociceptin	Rattus norvegicus	51-62
12522077-1	2003	1 The pharmacological profiles of presynaptic nociceptin/orphanin FQ (N/OFQ) peptide receptors (NOP) modulating 5-hydroxytryptamine (5-HT) and noradrenaline (NE) release in the rat neocortex were characterized in a preparation of superfused synaptosomes challenged with 10 mM KCl.	Norepinephrine	143-156	prepronociceptin	Rattus norvegicus	46-56
12522077-1	2003	1 The pharmacological profiles of presynaptic nociceptin/orphanin FQ (N/OFQ) peptide receptors (NOP) modulating 5-hydroxytryptamine (5-HT) and noradrenaline (NE) release in the rat neocortex were characterized in a preparation of superfused synaptosomes challenged with 10 mM KCl.	Norepinephrine	143-156	prepronociceptin	Rattus norvegicus	57-68
12488332-0	2003	Immunolesion of norepinephrine and epinephrine afferents to medial hypothalamus alters basal and 2-deoxy-D-glucose-induced neuropeptide Y and agouti gene-related protein messenger ribonucleic acid expression in the arcuate nucleus.	Norepinephrine	16-30	neuropeptide Y	Homo sapiens	123-137
12474218-1	2002	We have previously reported a highly sensitive method for the measurement of catechol-O-methyltransferase (COMT) activities in rat erythrocytes with norepinephrine (NE), an endogenous native substrate, using high-performance liquid chromatography (HPLC)-fluorescence or peroxyoxalate chemiluminescence reaction detection.	Norepinephrine	149-163	catechol-O-methyltransferase	Rattus norvegicus	77-105
12474218-1	2002	We have previously reported a highly sensitive method for the measurement of catechol-O-methyltransferase (COMT) activities in rat erythrocytes with norepinephrine (NE), an endogenous native substrate, using high-performance liquid chromatography (HPLC)-fluorescence or peroxyoxalate chemiluminescence reaction detection.	Norepinephrine	149-163	catechol-O-methyltransferase	Rattus norvegicus	107-111
12375271-4	2002	It has recently been demonstrated that the beta(3)-adrenergic receptor is the functionally relevant adrenergic receptor subtype in brown adipocytes and that its stimulation by noradrenaline (NA) modulates the expression of genes, such as uncoupling protein (UCP)-1 and inducible nitric oxide synthase (iNOS), involved in fat cell proliferation and differentiation.	Norepinephrine	176-189	adrenoceptor beta 3	Homo sapiens	43-70
12375271-4	2002	It has recently been demonstrated that the beta(3)-adrenergic receptor is the functionally relevant adrenergic receptor subtype in brown adipocytes and that its stimulation by noradrenaline (NA) modulates the expression of genes, such as uncoupling protein (UCP)-1 and inducible nitric oxide synthase (iNOS), involved in fat cell proliferation and differentiation.	Norepinephrine	176-189	uncoupling protein 1	Homo sapiens	238-264
12438093-1	2002	Phenylethanolamine N-methyltransferase (PNMT) methylates norepinephrine (NE) to form epinephrine (E).	Norepinephrine	57-71	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-38
12438093-1	2002	Phenylethanolamine N-methyltransferase (PNMT) methylates norepinephrine (NE) to form epinephrine (E).	Norepinephrine	57-71	phenylethanolamine-N-methyltransferase	Rattus norvegicus	40-44
12084707-8	2002	Transient transfection assay using luciferase reporter constructs also indicates that the two half-site CREs are involved in transcriptional regulation of Ucp1 in response to norepinephrine and cAMP.	Norepinephrine	175-189	uncoupling protein 1	Homo sapiens	155-159
12383975-3	2002	To this aim, we carried out the present immunohistochemistry study using two antibodies raised against dopamine beta-hydroxylase (DBH), the enzyme responsible for the conversion of dopamine into noradrenaline, and against the dopamine transporter (DAT), as markers for noradrenergic and dopaminergic fibers, respectively.	Norepinephrine	195-208	dopamine beta-hydroxylase	Rattus norvegicus	103-128
12383975-3	2002	To this aim, we carried out the present immunohistochemistry study using two antibodies raised against dopamine beta-hydroxylase (DBH), the enzyme responsible for the conversion of dopamine into noradrenaline, and against the dopamine transporter (DAT), as markers for noradrenergic and dopaminergic fibers, respectively.	Norepinephrine	195-208	dopamine beta-hydroxylase	Rattus norvegicus	130-133
12163351-0	2002	Direct and indirect inhibition by nociceptin/orphanin FQ on noradrenaline release from rodent cerebral cortex in vitro.	Norepinephrine	60-73	prepronociceptin	Rattus norvegicus	34-44
12163351-0	2002	Direct and indirect inhibition by nociceptin/orphanin FQ on noradrenaline release from rodent cerebral cortex in vitro.	Norepinephrine	60-73	prepronociceptin	Rattus norvegicus	45-56
12163351-1	2002	1 The modulation exerted by nociceptin/orphanin FQ (NC) on noradrenaline (NE) release in rodent cerebral cortex slices and synaptosomes was studied.	Norepinephrine	59-72	prepronociceptin	Rattus norvegicus	28-38
12163351-1	2002	1 The modulation exerted by nociceptin/orphanin FQ (NC) on noradrenaline (NE) release in rodent cerebral cortex slices and synaptosomes was studied.	Norepinephrine	59-72	prepronociceptin	Rattus norvegicus	39-50
12172218-0	2002	Enhanced vasoconstriction to endothelin-1, angiotensin II and noradrenaline in carriers of the GNB3 825T allele in the skin microcirculation.	Norepinephrine	62-75	G protein subunit beta 3	Homo sapiens	95-99
11965360-1	2002	Gene expression of phenylethanolamine N-methyltransferase (PNMT), the enzyme catalyzing conversion of norepinephrine to epinephrine, has been detected in rat spleen using the reverse transcription polymerase chain reaction.	Norepinephrine	102-116	phenylethanolamine-N-methyltransferase	Rattus norvegicus	19-57
11965360-1	2002	Gene expression of phenylethanolamine N-methyltransferase (PNMT), the enzyme catalyzing conversion of norepinephrine to epinephrine, has been detected in rat spleen using the reverse transcription polymerase chain reaction.	Norepinephrine	102-116	phenylethanolamine-N-methyltransferase	Rattus norvegicus	59-63
12575297-1	2002	OBJECTIVE: To explore the interaction of low-dosage aspirin combined with angiotensin-converting enzyme (ACE) inhibitors by prostacyclin (PGI2), thromboxone A2 (TXA2) and norepinephrine (NE)) levels in rabbits" blood.	Norepinephrine	171-185	angiotensin-converting enzyme	Oryctolagus cuniculus	105-108
11943777-1	2002	The homeodomain transcription factor Arix/Phox2a plays a critical role in the specification of noradrenergic neurons by inducing the expression of dopamine beta-hydroxylase (DBH), the terminal enzyme for noradrenaline biosynthesis.	Norepinephrine	204-217	dopamine beta-hydroxylase	Homo sapiens	147-172
11943777-1	2002	The homeodomain transcription factor Arix/Phox2a plays a critical role in the specification of noradrenergic neurons by inducing the expression of dopamine beta-hydroxylase (DBH), the terminal enzyme for noradrenaline biosynthesis.	Norepinephrine	204-217	dopamine beta-hydroxylase	Homo sapiens	174-177
12010762-6	2002	Hence, on the one hand, trans-10, cis-12 inhibited uncoupling protein (UCP) 1 induction by norepinephrine (NE) and produced a decrease in leptin mRNA levels.	Norepinephrine	91-105	uncoupling protein 1	Homo sapiens	51-77
12010186-3	2002	The activity of COMT was estimated by the metabolism of noradrenaline to metanephrine (MN), both measured by high-performance liquid chromatography with electrochemical detection.	Norepinephrine	56-69	catechol-O-methyltransferase	Rattus norvegicus	16-20
12102462-1	2002	Norepinephrine (NE), a vital neurotransmitter in both the central and peripheral nervous systems, is synthesized by dopamine beta-hydroxylase (DBH) through the oxidation of dopamine (DA) to NE.	Norepinephrine	0-14	dopamine beta-hydroxylase	Homo sapiens	116-141
12102462-1	2002	Norepinephrine (NE), a vital neurotransmitter in both the central and peripheral nervous systems, is synthesized by dopamine beta-hydroxylase (DBH) through the oxidation of dopamine (DA) to NE.	Norepinephrine	0-14	dopamine beta-hydroxylase	Homo sapiens	143-146
12057030-3	2002	Platelet I1 sites were quantified by p-[125I]iodoclonidine binding (0.5-15 nM) and displaced by moxonidine under a saturating concentration of norepinephrine to mask alpha2-adrenoceptors.	Norepinephrine	143-157	nischarin	Homo sapiens	9-11
11809916-9	2002	Furthermore, the peak epinephrine to norepinephrine ratio appearing between P7 and P10 in the normoxic offspring was absent in the hypoxic offspring.	Norepinephrine	37-51	solute carrier family 10, member 7	Rattus norvegicus	76-86
11742803-2	2002	Quiescent brown preadipocytes express high levels of UCP-1 mRNA in response to triiodothyronine (T3) and norepinephrine (NE).	Norepinephrine	105-119	uncoupling protein 1	Homo sapiens	53-58
11739311-4	2001	METHODS AND RESULTS: In primary cardiac myocytes from neonatal rats, immunohistochemical analyses using a specific monoclonal antibody against LOX-1 demonstrated that LOX-1 expression was markedly induced by stimulation with norepinephrine and endothelin-1.	Norepinephrine	225-239	oxidized low density lipoprotein receptor 1	Rattus norvegicus	143-148
11739311-4	2001	METHODS AND RESULTS: In primary cardiac myocytes from neonatal rats, immunohistochemical analyses using a specific monoclonal antibody against LOX-1 demonstrated that LOX-1 expression was markedly induced by stimulation with norepinephrine and endothelin-1.	Norepinephrine	225-239	oxidized low density lipoprotein receptor 1	Rattus norvegicus	167-172
11532994-5	2001	These include, as Fe(II), facilitating the production of dopamine from phenylalanine by tyrosine hydroxylase, and as heme, assisting the recycling of ascorbate by cytochrome b-561 required for the generation of norepinephrine from dopamine by dopamine beta-hydroxylase.	Norepinephrine	211-225	cytochrome b-561	Rattus norvegicus	163-179
11465644-1	2001	We performed this study to investigate whether changes in plasma glucose, insulin, and norepinephrine concentrations during an oral glucose tolerance test (OGTT) are associated with changes in plasma leptin levels in normotensive and hypertensive obese women.	Norepinephrine	87-101	leptin	Homo sapiens	200-206
11465644-4	2001	Area under curve (AUC) for plasma leptin showed a direct correlation with norepinephrine AUC in both NT-Ob (r = 0.73, P = .001) and HT-Ob (r = 0.74, P = .001) group, which was still detectable in multivariate analysis (P = .014 and P = .017, respectively).	Norepinephrine	74-88	leptin	Homo sapiens	34-40
11465644-5	2001	Our study confirms that glucose loading increases circulating leptin concentrations in obese women, and demonstrates the existance of an association between leptin and norepinephrine changes during OGTT in both normotensive and hypertensive obese women.	Norepinephrine	168-182	leptin	Homo sapiens	157-163
11406127-4	2001	The level of norepinephrine in the spinal cord of beta3-/- mice was 44% less than that of beta3+/+ mice, and did not differ in the brainstem, cortex or striatum.	Norepinephrine	13-27	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	50-55
11264717-3	2001	In vitro studies showed that mPer1 mRNA and mPER1 protein in mouse pineal gland are induced following the activation of a signalling pathway of fundamental importance for pineal physiology, the norepinephrine/cAMP/phosphoCREB cascade.	Norepinephrine	194-208	period circadian clock 1	Mus musculus	29-34
11264717-3	2001	In vitro studies showed that mPer1 mRNA and mPER1 protein in mouse pineal gland are induced following the activation of a signalling pathway of fundamental importance for pineal physiology, the norepinephrine/cAMP/phosphoCREB cascade.	Norepinephrine	194-208	period circadian clock 1	Mus musculus	44-49
11306173-5	2001	When HB2 cells were stimulated by norepinephrine, the VEGF mRNA level increased without a change in that of VEGF-B, while the VEGF-C mRNA level decreased.	Norepinephrine	34-48	vascular endothelial growth factor B	Mus musculus	108-114
11181015-1	2001	An impairment of norepinephrine (NE) re-uptake by the neuronal NE transporter (NET) has been shown to contribute to the increased cardiac net-release of NE in congestive heart failure (CHF).	Norepinephrine	17-31	solute carrier family 6 member 2	Rattus norvegicus	63-77
11181015-1	2001	An impairment of norepinephrine (NE) re-uptake by the neuronal NE transporter (NET) has been shown to contribute to the increased cardiac net-release of NE in congestive heart failure (CHF).	Norepinephrine	17-31	solute carrier family 6 member 2	Rattus norvegicus	79-82
11181015-1	2001	An impairment of norepinephrine (NE) re-uptake by the neuronal NE transporter (NET) has been shown to contribute to the increased cardiac net-release of NE in congestive heart failure (CHF).	Norepinephrine	17-31	solute carrier family 6 member 2	Rattus norvegicus	138-141
11321513-10	2001	The postprandial rise in plasma leptin was accompanied by a marked increment in gut hormones; gastrin, CCK and PP and stress hormones such as norepinephrine, cortisol and GH.	Norepinephrine	142-156	leptin	Homo sapiens	32-38
28095225-3	2001	administration of noradrenaline were markedly enhanced in eNOS knockout mice.	Norepinephrine	18-31	nitric oxide synthase 3, endothelial cell	Mus musculus	58-62
11258636-3	2001	At the point of exhaustion significantly higher values for norepinephrine and epinephrine were observed in ST2 than in ST1.	Norepinephrine	59-73	syndecan binding protein	Homo sapiens	119-122
11133901-7	2001	At sea level, plasma norepinephrine levels during exercise were 48% greater when subjects were alpha-blocked compared with their placebo trial.	Norepinephrine	21-35	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	3-6
11173978-2	2001	The ADH1 enzymes, the classical liver forms, are involved in several metabolic pathways beside the oxidation of ethanol, e.g. norepinephrine, dopamine, serotonin and bile acid metabolism.	Norepinephrine	126-140	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	4-8
11752890-2	2001	IL-1 and LPS are known to affect cerebral neurotransmission involving norepinephrine and serotonin, both of which have been implicated in feeding behavior and in the pharmacotherapy of depression in man.	Norepinephrine	70-84	interleukin 1 alpha	Homo sapiens	0-4
11179598-3	2001	Blockade of CRH receptors with alphah-CRF (10 microg) attenuated or blocked the BN-induced rise in plasma ACTH, epinephrine, norepinephrine, glucose and corticosterone levels.	Norepinephrine	125-139	corticotropin releasing hormone	Homo sapiens	12-15
11080198-0	2000	Neuropeptide Y cotransmission with norepinephrine in the sympathetic nerve-macrophage interplay.	Norepinephrine	35-49	neuropeptide Y	Homo sapiens	0-14
11080198-2	2000	To study the nerve-macrophage communication, a superfusion method was used to investigate cotransmission of neuropeptide Y (NPY) with norepinephrine (NE), with interleukin (IL)-6 secretion used as the macrophage read-out parameter.	Norepinephrine	134-148	neuropeptide Y	Homo sapiens	124-127
11028916-10	2000	Since PHM is homologous in sequence and mechanism to dopamine beta-monooxygenase (DBM; EC 1.14.17.1), the enzyme that converts dopamine to norepinephrine during catecholamine biosynthesis, these structural and mechanistic insights are extended to DBM.	Norepinephrine	139-153	dopamine beta-hydroxylase	Rattus norvegicus	53-80
10848638-3	2000	Plasma noradrenaline was gradually suppressed (P &lt; 0.05) by 62 +/- 8 and 104 +/- 11 pg mL-1 during xiphoid and neck immersion, respectively, indicating a graded suppression of sympathetic nervous activity.	Norepinephrine	7-20	L1 cell adhesion molecule	Mus musculus	90-94
10866041-6	2000	Adipocytes isolated from AFABP-KO and WT mice fed high- or low-fat diets exhibited similar rates of basal and norepinephrine-stimulated lipolysis and insulin-stimulated rates of glucose conversion to fatty acids and glyceride-glycerol.	Norepinephrine	110-124	fatty acid binding protein 4, adipocyte	Mus musculus	25-30
10942111-1	2000	Non-neuronal monoamine transporters OCT1, OCT2, and EMT, which are all members of the amphiphilic solute facilitator family, control signal transmission by removing released transmitters, such as dopamine, noradrenaline, adrenaline, 5-hydroxytryptamine, and histamine, from the extracellular space.	Norepinephrine	206-219	solute carrier family 22 member 2	Homo sapiens	42-46
10942111-1	2000	Non-neuronal monoamine transporters OCT1, OCT2, and EMT, which are all members of the amphiphilic solute facilitator family, control signal transmission by removing released transmitters, such as dopamine, noradrenaline, adrenaline, 5-hydroxytryptamine, and histamine, from the extracellular space.	Norepinephrine	206-219	IL2 inducible T cell kinase	Homo sapiens	52-55
10997647-1	2000	OBJECTIVES: To determine the dependence of plasma leptin concentrations upon circulating noradrenaline (NA) and thyroid hormones (TH) in humans.	Norepinephrine	89-102	leptin	Homo sapiens	50-56
10718926-0	2000	Adrenoceptor subtype involvement in suppression of prolactin secretion by noradrenaline.	Norepinephrine	74-87	prolactin	Ovis aries	51-60
10718926-1	2000	In sheep, injection of noradrenaline suppresses prolactin secretion by a direct effect at the pituitary gland.	Norepinephrine	23-36	prolactin	Ovis aries	48-57
10718926-2	2000	The aims of this study were to use primary cultures of ovine pituitary cells to examine the receptor subtypes that mediate the inhibitory effect of noradrenaline on prolactin secretion and, by using receptor antagonists in vivo, determine whether noradrenaline acts as a prolactin release-inhibiting factor (PIF).	Norepinephrine	148-161	prolactin	Ovis aries	165-174
10718926-3	2000	Noradrenaline and dopamine suppressed prolactin secretion from ovine pituitary cells with ED50s of 60.9+/-46.6 and 1.5+/-1.0x10-9 mol/l, respectively (P&lt;0.05).	Norepinephrine	0-13	prolactin	Ovis aries	38-47
10718926-4	2000	The in-vitro prolactin release-inhibiting effect of noradrenaline (10-7 mol/l) was not blocked by the dopamine antagonists pimozide (D2) or SCH23390 (D1) but was blocked by each of the adrenoceptor antagonists (alpha1-adrenoceptor antagonists prazosin and WB4101, the alpha2-adrenoceptor antagonist yohimbine and the beta-adrenoceptor antagonist propranolol).	Norepinephrine	52-65	prolactin	Ovis aries	13-22
10737636-8	2000	PNMT is the enzyme that converts noradrenaline to adrenaline and is not expressed in noradrenaline-secreting cells.	Norepinephrine	33-46	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-4
10845761-4	2000	All neurogenic constrictor responses are related to the release of norepinephrine from adrenergic nerves that act on post-junctional alpha-1 and pre-junctional and post-junctional alpha-2 receptor subtypes.	Norepinephrine	67-81	adrenoceptor alpha 1D	Homo sapiens	133-140
10678267-7	2000	During MST-1, norepinephrine increased by 461 +/-165 pmol/L (mean +/- SEM) and epinephrine by 218 +/- 76 pmol/L.	Norepinephrine	14-28	macrophage stimulating 1	Homo sapiens	7-12
10465291-2	1999	In preadipocytes, norepinephrine (NE) increased cAMP levels but the beta3-agonists BRL-37344 and CGP-12177 did not; in contrast, when the cells had differentiated into mature brown adipocytes, a large cAMP response to the beta3-agonists had emerged and was now double that to NE (although the affinity of NE had increased 10-fold).	Norepinephrine	18-32	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	222-227
10502659-2	1999	Noradrenaline and potassium chloride induced concentration-dependent vasoconstrictions in both vessel types but the basal tension, maximum tension, and the -log concentration producing half-maximal response (pEC50) were altered in the presence of 0.1 or 20 U ml-1 EPO.	Norepinephrine	0-13	erythropoietin	Rattus norvegicus	264-267
10425201-6	1999	Murine recombinant leptin (&gt;==50 nM) strongly induced the release of both epinephrine (E) and norepinephrine (NE) from chromaffin cells.	Norepinephrine	97-111	leptin	Mus musculus	19-25
10475560-2	1999	The study focused on the autonomic messengers neuropeptide Y (NPY), tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of noradrenaline (NA), and vasoactive intestinal polypeptide (VIP).	Norepinephrine	140-153	neuropeptide Y	Homo sapiens	46-60
10475560-2	1999	The study focused on the autonomic messengers neuropeptide Y (NPY), tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of noradrenaline (NA), and vasoactive intestinal polypeptide (VIP).	Norepinephrine	140-153	neuropeptide Y	Homo sapiens	62-65
10411589-3	1999	There were small but significant differences between the rat NET and the human or bovine NETs with respect to the affinities of sodium ions (greater for rat than for bovine) of the substrates norepinephrine, epinephrine, and 1-methyl-4-phenylpyridinium (greater for human than for rat), and of the inhibitor cocaine (greater for human and bovine than for rat), whereas the affinities of dopamine and of most inhibitors, including tricyclic antidepressants, showed no species differences.	Norepinephrine	192-206	solute carrier family 6 member 2	Rattus norvegicus	61-64
10381895-7	1999	Pulmonary vasopressor responses to endothelin-1 (ET-1), angiotensin II, and ventilatory hypoxia were reduced significantly in animals transfected with the eNOS gene, whereas pressor responses to norepinephrine and U46619 were not changed.	Norepinephrine	195-209	nitric oxide synthase 3, endothelial cell	Mus musculus	155-159
10224140-10	1999	Acidic metabolites of neurotransmitters derived from dopamine, epinephrine, norepinephrine, and serotonin inhibited the uptake of estrone sulfate via OAT3.	Norepinephrine	76-90	solute carrier family 22 member 8	Rattus norvegicus	150-154
10215671-4	1999	alpha-Methylnoradrenaline dose-dependently increased heart rate, systolic blood pressure, cardiac output, blood glucose, serum insulin, free fatty acids, and gastrin, shortened the duration of heart rate-corrected electromechanical systole, and decreased diastolic blood pressure, total peripheral resistance, and plasma noradrenaline.	Norepinephrine	12-25	gastrin	Homo sapiens	158-165
10205006-0	1999	Adenosine 5"-triphosphate and neuropeptide Y are co-transmitters in conjunction with noradrenaline in the human saphenous vein.	Norepinephrine	85-98	neuropeptide Y	Homo sapiens	30-44
10535688-6	1999	In contrast, the beta2-adrenoceptor-mediated relaxations of the noradrenaline-constricted pulmonary artery and aorta did not display a significant loss of sensitivity.	Norepinephrine	64-77	adrenoceptor beta 2	Rattus norvegicus	17-35
10700334-1	1999	Neuropeptide Y(NPY) co-exists with norepinephrine in the sympathetic nervous system, and NPY may represent the sympathetic-neuronal output.	Norepinephrine	35-49	neuropeptide Y	Homo sapiens	0-19
10068346-2	1999	In vitro application of noradrenaline stimulates expression of cytoskeletal filaments, particularly actin and myosin, by prostatic stromal cells, thus enhancing their differentiation towards smooth muscle cells.	Norepinephrine	24-37	myosin heavy chain 14	Homo sapiens	110-116
10050962-5	1999	When available, plasma samples were evaluated first for levels of 3-methoxy, 4-hydroxyphenolglycol (MHPG), a metabolite of norepinephrine which serves as the most sensitive index of MAO-A activity in humans.	Norepinephrine	123-137	monoamine oxidase A	Homo sapiens	182-187
10073744-1	1999	AIMS: Neuropeptide Y (NPY) is a sympathetic neurotransmitter released with noradrenaline during sympathetic stimulation.	Norepinephrine	75-88	neuropeptide Y	Homo sapiens	6-20
10073744-1	1999	AIMS: Neuropeptide Y (NPY) is a sympathetic neurotransmitter released with noradrenaline during sympathetic stimulation.	Norepinephrine	75-88	neuropeptide Y	Homo sapiens	22-25
9889075-3	1999	Here we find that 8-Br-cAMP, norepinephrine, or SKF38393 given 3 h posttraining into rat CA1 reverses the amnestic effect of KN-62 given into the amygdala 0 h after training, but not that of KN-62 given into CA1 0 h posttraining.	Norepinephrine	29-43	carbonic anhydrase 1	Rattus norvegicus	89-92
9889075-3	1999	Here we find that 8-Br-cAMP, norepinephrine, or SKF38393 given 3 h posttraining into rat CA1 reverses the amnestic effect of KN-62 given into the amygdala 0 h after training, but not that of KN-62 given into CA1 0 h posttraining.	Norepinephrine	29-43	carbonic anhydrase 1	Rattus norvegicus	208-211
9881594-4	1998	Comparison of the effects of anti-B-50 antibodies on glutamate and noradrenaline release from permeated synaptosomes revealed two major differences.	Norepinephrine	67-80	growth associated protein 43	Homo sapiens	34-38
9828226-0	1998	Connexin 32 gap junctions enhance stimulation of glucose output by glucagon and noradrenaline in mouse liver.	Norepinephrine	80-93	gap junction protein, beta 1	Mus musculus	0-11
9763470-1	1998	Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline and is selectively expressed in noradrenergic and adrenergic neurons and neuroendocrine cells.	Norepinephrine	72-85	dopamine beta-hydroxylase	Homo sapiens	0-25
9763470-1	1998	Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline and is selectively expressed in noradrenergic and adrenergic neurons and neuroendocrine cells.	Norepinephrine	72-85	dopamine beta-hydroxylase	Homo sapiens	27-30
9763638-16	1998	Forskolin, an activator of endogenous adenylate cyclase, and 3-isobutyl-1-methylxanthine, a phosphodiesterase inhibitor, mimicked the ability of noradrenaline to increase both steady-state pHi and rates of pHi recovery from imposed acid loads, as did Sp-cAMPS, a selective activator of cAMP-dependent protein kinase.	Norepinephrine	145-158	glucose-6-phosphate isomerase	Rattus norvegicus	189-192
9763638-16	1998	Forskolin, an activator of endogenous adenylate cyclase, and 3-isobutyl-1-methylxanthine, a phosphodiesterase inhibitor, mimicked the ability of noradrenaline to increase both steady-state pHi and rates of pHi recovery from imposed acid loads, as did Sp-cAMPS, a selective activator of cAMP-dependent protein kinase.	Norepinephrine	145-158	glucose-6-phosphate isomerase	Rattus norvegicus	206-209
9763638-19	1998	Noradrenaline also increased steady-state pHi and rates of pHi recovery from imposed acid loads in cultured postnatal rat hippocampal neurones.	Norepinephrine	0-13	glucose-6-phosphate isomerase	Rattus norvegicus	42-45
9763638-19	1998	Noradrenaline also increased steady-state pHi and rates of pHi recovery from imposed acid loads in cultured postnatal rat hippocampal neurones.	Norepinephrine	0-13	glucose-6-phosphate isomerase	Rattus norvegicus	59-62
9763638-22	1998	We conclude that noradrenaline increases the activity of the Na+-H+ exchanger in rat hippocampal neurones, probably by inducing an alkaline shift in the pHi dependence of the antiport, thereby raising steady-state pHi.	Norepinephrine	17-30	glucose-6-phosphate isomerase	Rattus norvegicus	153-156
9763638-22	1998	We conclude that noradrenaline increases the activity of the Na+-H+ exchanger in rat hippocampal neurones, probably by inducing an alkaline shift in the pHi dependence of the antiport, thereby raising steady-state pHi.	Norepinephrine	17-30	glucose-6-phosphate isomerase	Rattus norvegicus	214-217
9724817-3	1998	We now show that the primate ovary expresses both the genes encoding TH and dopamine beta-hydroxylase (DBH), the key enzymes in norepinephrine (NE) biosynthesis.	Norepinephrine	128-142	dopamine beta-hydroxylase	Homo sapiens	76-101
9724817-3	1998	We now show that the primate ovary expresses both the genes encoding TH and dopamine beta-hydroxylase (DBH), the key enzymes in norepinephrine (NE) biosynthesis.	Norepinephrine	128-142	dopamine beta-hydroxylase	Homo sapiens	103-106
9619531-2	1998	It has been speculated that the neurotransmitter norepinephrine (NE) (noradrenaline), possibly via the sympathetic nervous system, may represent the afferent signal which modulates leptin release from adipocytes.	Norepinephrine	49-63	leptin	Homo sapiens	181-187
9619531-2	1998	It has been speculated that the neurotransmitter norepinephrine (NE) (noradrenaline), possibly via the sympathetic nervous system, may represent the afferent signal which modulates leptin release from adipocytes.	Norepinephrine	70-83	leptin	Homo sapiens	181-187
9730267-0	1998	The role of MAO-A and MAO-B in the metabolic degradation of noradrenaline in human arteries.	Norepinephrine	60-73	monoamine oxidase A	Homo sapiens	12-17
9730267-12	1998	In conclusion, three major differences distinguish the metabolism of noradrenaline by human arteries from that observed in other species: (1) the large predominance of deamination over O-methylation; (2) the extremely high formation of DOMA; and (3) the relative lack of selectivity of clorgyline and selegiline for MAO-A and B, respectively.	Norepinephrine	69-82	monoamine oxidase A	Homo sapiens	316-327
9568844-7	1998	RESULTS: In kidneys preconstricted by noradrenaline (NA 1.5 x 10(-7) mol/l) VEGF/VPF (155 pmol/l) caused an almost complete return of renal perfusion flow rate to pre-NA values (before NA 113 +/- 4%, after NA 100%, 15 min with VEGF/VPF 111 +/- 4%).	Norepinephrine	38-51	vascular endothelial growth factor A	Rattus norvegicus	76-84
14684374-0	2004	Coupling of angiotensin II AT1 receptors to neuronal NHE activity and carrier-mediated norepinephrine release in myocardial ischemia.	Norepinephrine	87-101	angiotensin II receptor type 1	Homo sapiens	27-30
14716224-0	2004	AT1 and AT2-receptor antagonists inhibit Ang II-mediated facilitation of noradrenaline release in human atria.	Norepinephrine	73-86	angiotensin II receptor type 1	Homo sapiens	0-3
14716224-0	2004	AT1 and AT2-receptor antagonists inhibit Ang II-mediated facilitation of noradrenaline release in human atria.	Norepinephrine	73-86	angiotensin II receptor type 2	Homo sapiens	8-11
14716224-7	2004	Moreover, the selective AT2-receptor antagonists PD123319 and CGP42112A (0.1 and 1 micromol/L) also inhibited Ang II-induced facilitation of noradrenaline release.	Norepinephrine	141-154	angiotensin II receptor type 2	Homo sapiens	24-27
14716224-10	2004	In conclusion, both AT1- and AT2-receptors seem to play a role in Ang II-mediated facilitation of noradrenaline release in the human heart.	Norepinephrine	98-111	angiotensin II receptor type 1	Homo sapiens	20-23
14716224-10	2004	In conclusion, both AT1- and AT2-receptors seem to play a role in Ang II-mediated facilitation of noradrenaline release in the human heart.	Norepinephrine	98-111	angiotensin II receptor type 2	Homo sapiens	29-32
14730205-0	2004	The inhibitory effect of trilinolein on norepinephrine-induced beta-myosin heavy chain promoter activity, reactive oxygen species generation, and extracellular signal-regulated kinase phosphorylation in neonatal rat cardiomyocytes.	Norepinephrine	40-54	myosin heavy chain 7	Rattus norvegicus	63-86
14697877-5	2004	MAO A KO mice showed increased levels of serotonin (5-HT), norepinephrine (NE), dopamine (DA) whereas MAO B KO mice showed increased phenylethylamine (PEA) levels only.	Norepinephrine	59-73	monoamine oxidase A	Mus musculus	0-5
12736159-1	2003	Norepinephrine stimulates lipolysis and concurrently inhibits insulin-stimulated leptin secretion from white adipocytes.	Norepinephrine	0-14	leptin	Rattus norvegicus	81-87
12736159-3	2003	Palmitic acid (1 mM) mimicked the inhibitory effects of norepinephrine (1 microM) on insulin (10 nM)-stimulated leptin secretion, but only at low albumin concentrations.	Norepinephrine	56-70	leptin	Rattus norvegicus	112-118
12736159-8	2003	These results demonstrate that long-chain fatty acids mimic the effects of norepinephrine on leptin secretion and suggest that they may play a regulatory role as messengers between stimulation of lipolysis by norepinephrine and inhibition of leptin secretion.	Norepinephrine	75-89	leptin	Rattus norvegicus	93-99
16751253-6	2006	Likewise, a reduction in pressor responses to noradrenaline was observed in hypertensive rats treated with IGF-IR antisense compared with full mismatch-treated rats (E(max) was reduced to 60 +/- 6 mm Hg compared with 108 +/- 5 mm Hg, p &lt; 0.01).	Norepinephrine	46-59	insulin-like growth factor 1 receptor	Rattus norvegicus	107-113
16828079-6	2006	A metalloproteinase inhibitor, an anti-heparin-binding-EGF-selective antibody, and a selective EGF-receptor kinase inhibitor blocked the alpha1B-adrenoceptor phosphorylation induced by noradrenaline or endothelin-1.	Norepinephrine	185-198	epidermal growth factor like 1	Rattus norvegicus	55-58
16828079-6	2006	A metalloproteinase inhibitor, an anti-heparin-binding-EGF-selective antibody, and a selective EGF-receptor kinase inhibitor blocked the alpha1B-adrenoceptor phosphorylation induced by noradrenaline or endothelin-1.	Norepinephrine	185-198	epidermal growth factor like 1	Rattus norvegicus	95-98
16828079-6	2006	A metalloproteinase inhibitor, an anti-heparin-binding-EGF-selective antibody, and a selective EGF-receptor kinase inhibitor blocked the alpha1B-adrenoceptor phosphorylation induced by noradrenaline or endothelin-1.	Norepinephrine	185-198	adrenoceptor alpha 1B	Rattus norvegicus	137-157
16765344-0	2006	Centrally administered histamine evokes the adrenal secretion of noradrenaline and adrenaline by brain cyclooxygenase-1- and thromboxane A2-mediated mechanisms in rats.	Norepinephrine	65-78	prostaglandin-endoperoxide synthase 1	Rattus norvegicus	103-119
16765344-11	2006	These results suggest that centrally administered histamine evokes plasma noradrenaline and adrenaline from adrenal medulla by brain cyclooxygenase-1- and thromboxane A(2)-mediated mechanisms in rats.	Norepinephrine	74-87	prostaglandin-endoperoxide synthase 1	Rattus norvegicus	133-149
9608607-0	1998	Mechanism of triazolo-benzodiazepine and benzodiazepine action in anxiety and depression: behavioral studies with concomitant in vivo CA1 hippocampal norepinephrine and serotonin release detection in the behaving animal.	Norepinephrine	150-164	carbonic anhydrase 1	Rattus norvegicus	134-137
12865312-4	2003	Norepinephrine caused a parallel increase in phosphorylated p42/44 MAPK (p42/44(MAPK)) and p90RSK that was reduced by prazosin or propranolol, indicating involvement of both alpha(1)- and beta-adrenergic receptors.	Norepinephrine	0-14	mitogen activated protein kinase 1	Rattus norvegicus	60-71
12887689-0	2003	Noradrenaline induces expression of peroxisome proliferator activated receptor gamma (PPARgamma) in murine primary astrocytes and neurons.	Norepinephrine	0-13	peroxisome proliferator activated receptor gamma	Mus musculus	36-84
7883959-11	1995	beta 3-Adrenoceptor sensitivity, but not alpha 2-, beta 1-, or beta 2-adrenoceptor sensitivity, correlated with norepinephrine-induced lipolysis (r = -0.67, P = 0.0001) and fat cell volume (r = -0.71, P = 0.0001).	Norepinephrine	112-126	adrenoceptor beta 3	Homo sapiens	0-19
12887689-0	2003	Noradrenaline induces expression of peroxisome proliferator activated receptor gamma (PPARgamma) in murine primary astrocytes and neurons.	Norepinephrine	0-13	peroxisome proliferator activated receptor gamma	Mus musculus	86-95
7542993-1	1995	Glutamic acid (GA) and norepinephrine (NE) stimulate luteinizing hormone-releasing hormone (LHRH) release via release of nitric oxide (NO) from NOergic neurons in the arcuate-median eminence region.	Norepinephrine	23-37	gonadotropin releasing hormone 1	Rattus norvegicus	53-90
7542993-1	1995	Glutamic acid (GA) and norepinephrine (NE) stimulate luteinizing hormone-releasing hormone (LHRH) release via release of nitric oxide (NO) from NOergic neurons in the arcuate-median eminence region.	Norepinephrine	23-37	gonadotropin releasing hormone 1	Rattus norvegicus	92-96
7882052-0	1995	Corticotropin-releasing factor administered into the locus coeruleus, but not the parabrachial nucleus, stimulates norepinephrine release in the prefrontal cortex.	Norepinephrine	115-129	corticotropin releasing hormone	Homo sapiens	0-30
7882052-1	1995	Previous studies have indicated that intracerebroventricular application of corticotropin-releasing factor (CRF) activates noradrenergic neurons in the brain stem locus coeruleus (LC) and norepinephrine (NE) metabolism in several brain regions.	Norepinephrine	188-202	corticotropin releasing hormone	Homo sapiens	76-106
7806548-0	1994	Norepinephrine utilizes alpha 1- and beta-adrenoreceptors synergistically to maximally induce c-fos expression in brown adipocytes.	Norepinephrine	0-14	FBJ osteosarcoma oncogene	Mus musculus	94-99
7806548-1	1994	In order to examine how norepinephrine stimulates proliferation and differentiation in brown fat cells, we have investigated the ability of brown fat cells to respond to norepinephrine stimulation with an increase in the expression of the proto-oncogene c-fos.	Norepinephrine	24-38	FBJ osteosarcoma oncogene	Mus musculus	239-259
7806548-1	1994	In order to examine how norepinephrine stimulates proliferation and differentiation in brown fat cells, we have investigated the ability of brown fat cells to respond to norepinephrine stimulation with an increase in the expression of the proto-oncogene c-fos.	Norepinephrine	170-184	FBJ osteosarcoma oncogene	Mus musculus	239-259
7806548-2	1994	Stimulation of brown fat precursor cells (isolated from young mice and grown for 4 days in culture) with norepinephrine led to a marked but transient (maximal approximately 30 min) induction of c-fos expression.	Norepinephrine	105-119	FBJ osteosarcoma oncogene	Mus musculus	194-199
7806548-9	1994	It was concluded that norepinephrine, in agreement with its fundamental role in the control of brown fat cell growth and development, was able to induce c-fos expression, that this induction was not exclusively linked to promotion of either proliferation or differentiation, and that the induction was mediated via a distal synergism between beta/cAMP and alpha 1/[Ca2+]i pathways, thus conferring to the alpha 1-adrenoreceptors on the cell a potentially significant role in the control of cell growth and development.	Norepinephrine	22-36	FBJ osteosarcoma oncogene	Mus musculus	153-158
7844319-1	1994	3-Methoxy-4-hydroxyphenylglycol (MHPG) is formed by the sequential actions of monoamine oxidase (MAO) and catechol-O-methyltransferase on norepinephrine within extraneuronal tissues or by extraneuronal O-methylation of 3,4-dihydroxyphenylglycol (DHPG) produced intraneuronally from norepinephrine.	Norepinephrine	138-152	catechol-O-methyltransferase	Rattus norvegicus	106-134
7833428-4	1994	However, when the effects of CRH were followed over a longer period in a small subgroup, we found that CRH administration produced a two-fold rise in plasma HVA levels 20 hours later, without affecting plasma levels of 3-methoxy-4-hydroxyphenylglycol (MHPG), a major metabolite of norepinephrine.	Norepinephrine	281-295	corticotropin releasing hormone	Homo sapiens	103-106
7874313-0	1994	HIV-1 envelope protein gp120 potentiates NMDA-evoked noradrenaline release by a direct action at rat hippocampal and cortical noradrenergic nerve endings.	Norepinephrine	53-66	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	23-28
7525897-1	1994	Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine, and is expressed specifically in neurons and neuroendocrine cells that release norepinephrine and epinephrine.	Norepinephrine	72-86	dopamine beta-hydroxylase	Rattus norvegicus	0-25
12890395-4	2003	RESULTS: Plasma norepinephrine (NE) levels were significantly higher in patients with severe PIH than those in control subjects (P &lt; 0.05).	Norepinephrine	16-30	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	93-96
12817189-0	2003	Effects of angiotensin-(1-7) and other bioactive components of the renin-angiotensin system on vascular resistance and noradrenaline release in rat kidney.	Norepinephrine	119-132	renin	Rattus norvegicus	67-72
12871570-8	2003	Inhibition of brain MAO-A and -B by TV3326 resulted in significant elevations of dopamine, noradrenaline and serotonin in the striatum and hippocampus.	Norepinephrine	91-104	monoamine oxidase A	Rattus norvegicus	20-25
12654529-5	2003	The suppressive influence of muscimol in the MPOA on GnRH release might be considered a net result of its direct inhibitory effect on GnRH release, indirect inhibitory influence on GnRH release through activation of the beta-endorphinergic system, and facilitation of GnRH neurons by increasing noradrenaline release.	Norepinephrine	295-308	gonadotropin releasing hormone 1	Homo sapiens	53-57
12605405-1	2003	We studied the effects of serotonin and noradrenaline on the expression of arginine-vasopressin (AVP) and vasoactive intestinal peptide (VIP) in the suprachiasmatic nucleus (SCN).	Norepinephrine	40-53	arginine vasopressin	Mus musculus	75-95
12605405-1	2003	We studied the effects of serotonin and noradrenaline on the expression of arginine-vasopressin (AVP) and vasoactive intestinal peptide (VIP) in the suprachiasmatic nucleus (SCN).	Norepinephrine	40-53	arginine vasopressin	Mus musculus	97-100
12464610-3	2003	One such protein is a biogenic amine-binding protein (ABP) that binds serotonin, epinephrine, and norepinephrine.	Norepinephrine	98-112	amine oxidase, copper containing 1	Rattus norvegicus	31-52
12464610-3	2003	One such protein is a biogenic amine-binding protein (ABP) that binds serotonin, epinephrine, and norepinephrine.	Norepinephrine	98-112	amine oxidase, copper containing 1	Rattus norvegicus	54-57
12690638-5	2003	Since the CVS-induced modulation of CRH levels are consistent with an alteration of tyrosine hydroxylase levels in the locus coeruleus, CRH-norepinephrine (NE) interaction in the terminal projection of forebrain NE systems, PVN, BNST and CeA where NE stimulates CRII release, might contribute to the bi-directional change in CRH.	Norepinephrine	140-154	carcinoembryonic antigen gene family 4	Rattus norvegicus	238-241
12724950-0	2003	Thyrotropin releasing hormone (TRH) potentiates the metabolic effect of norepinephrine (NE) in warm-acclimated lean and obese rats.	Norepinephrine	72-86	thyrotropin releasing hormone	Rattus norvegicus	0-29
12724950-0	2003	Thyrotropin releasing hormone (TRH) potentiates the metabolic effect of norepinephrine (NE) in warm-acclimated lean and obese rats.	Norepinephrine	72-86	thyrotropin releasing hormone	Rattus norvegicus	31-34
16900785-6	2006	Intraperitoneal administration of AR at a dose of 1.5 mg/kg scarcely affected beta-endorphin and noradrenaline levels in the central nervous system of HSV-inoculated mice.	Norepinephrine	97-110	artemin	Mus musculus	34-36
16714015-2	2006	Combining the selective alpha(2A)-adrenoceptor antagonist, BRL-44408 (10 mg/kg, s.c.), with fluoxetine (30 mg/kg, s.c.) elevated the extracellular levels of serotonin (5-HT) and noradrenaline in the rat frontal cortex, an effect not observed following antidepressant treatment alone.	Norepinephrine	178-191	adrenoceptor alpha 2A	Rattus norvegicus	24-46
16677282-8	2006	RESULTS: Norepinephrine stimulated the expression of S100A8/S100A9 mRNAs via beta-adrenergic receptors in U-937 cells and significantly increased calprotectin production to about 3.6-fold that of the control.	Norepinephrine	9-23	S100 calcium binding protein A8	Homo sapiens	53-59
16672148-5	2006	Vascular maladaptation in preeclampsia with increased vasomotor tone, endothelial dysfunction, and increased sensitivity to angiotensin II and norepinephrine in manifest preeclampsia may be explained on the basis of angiotensin II-mediated mechanisms through angiotensin receptor type I (AT1) activation.	Norepinephrine	143-157	angiotensin II receptor type 1	Homo sapiens	216-291
16139986-2	2006	Noradrenaline (NA)-producing cells of the brain stem are involved in regulating GnRH cells and project to the preoptic area (POA) and bed nucleus of stria terminalis (BnST).	Norepinephrine	0-13	gonadotropin releasing hormone 1	Homo sapiens	80-84
16458982-1	2006	OBJECTIVE: We analysed the effect of aldosterone on calcitonin gene-related peptide (CGRP) mediated vasodilation in noradrenaline precontracted endothelium denuded mesenteric arteries segments from Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) and the effect of aldosterone on calcitonin receptor-like receptor (CL receptor) and receptor activity modifying protein 1 (RAMP1) expression in endothelium-denuded mesenteric arteries from SHR rats.	Norepinephrine	116-129	calcitonin-related polypeptide alpha	Rattus norvegicus	52-83
16458982-1	2006	OBJECTIVE: We analysed the effect of aldosterone on calcitonin gene-related peptide (CGRP) mediated vasodilation in noradrenaline precontracted endothelium denuded mesenteric arteries segments from Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) and the effect of aldosterone on calcitonin receptor-like receptor (CL receptor) and receptor activity modifying protein 1 (RAMP1) expression in endothelium-denuded mesenteric arteries from SHR rats.	Norepinephrine	116-129	calcitonin-related polypeptide alpha	Rattus norvegicus	85-89
16210420-9	2006	Norepinephrine (NE) concentration decreased significantly in the PVN, AN, and VMH after both intraperitoneal and intracerebroventricular administration of leptin (P &lt; 0.05).	Norepinephrine	0-14	leptin	Rattus norvegicus	155-161
16380518-0	2006	Injection of nerve growth factor into stellate ganglia improves norepinephrine reuptake into failing hearts.	Norepinephrine	64-78	nerve growth factor	Rattus norvegicus	13-32
16380518-3	2006	We hypothesized that injection of nerve growth factor into stellate ganglia normalizes cardiac norepinephrine homeostasis in experimental heart failure.	Norepinephrine	95-109	nerve growth factor	Rattus norvegicus	34-53
16380518-7	2006	As compared with saline, nerve growth factor refilled depleted cardiac norepinephrine stores and improved cardiac [3H]-norepinephrine uptake into isolated perfused hearts of transverse aortic constricted rats.	Norepinephrine	71-85	nerve growth factor	Rattus norvegicus	25-44
16439213-6	2006	Pharmacological or genetic ablation of adrenergic neurotransmission indicates that norepinephrine (NE) signaling controls G-CSF-induced osteoblast suppression, bone CXCL12 downregulation, and HSPC mobilization.	Norepinephrine	83-97	colony stimulating factor 3 (granulocyte)	Mus musculus	122-127
16439213-6	2006	Pharmacological or genetic ablation of adrenergic neurotransmission indicates that norepinephrine (NE) signaling controls G-CSF-induced osteoblast suppression, bone CXCL12 downregulation, and HSPC mobilization.	Norepinephrine	83-97	chemokine (C-X-C motif) ligand 12	Mus musculus	165-171
7965820-2	1994	IL-2 also increases hypothalamic norepinephrine turnover without affecting plasma corticosterone levels, which suggests that it selectively impacts on central sites that mediate sympathetic outflow to lymphoid organs.	Norepinephrine	33-47	interleukin 2	Mus musculus	0-4
17008773-3	2006	The endotoxin-induced increase in the EC(50) value of norepinephrine was decreased by phenylene-1,3-bis[ethane-2-isothiourea] dihydrobromide (1,3-PBIT), a selective inducible NO synthase inhibitor, and U0126, a selective inhibitor of ERK1/2 phosphorylation by MAPK kinase.	Norepinephrine	54-68	mitogen activated protein kinase 3	Rattus norvegicus	234-240
12797383-8	2003	The reduced locomotor activity of Gdnf+/- mice was accompanied by reductions in NE transporter activity in the cerebellum and brain stem as well as decreased norepinephrine tissue levels in the LC.	Norepinephrine	158-172	glial cell line derived neurotrophic factor	Mus musculus	34-38
12504920-3	2002	We hypothesized that norepinephrine (NE), acting on alpha(1) receptors in CeA, may modulate stress-induced anxiety-like behavioral responses and HPA activation.	Norepinephrine	21-35	carcinoembryonic antigen gene family 4	Rattus norvegicus	74-77
14567072-4	2002	Treatment of the aorta from both control and castrated rats with the alpha 1B/alpha 1D-adrenoceptor alkylating agent chloroethylclonidine resulted in approximately 1600-fold rightward shift in the concentration-response curves to noradrenaline.	Norepinephrine	230-243	adrenoceptor alpha 1D	Rattus norvegicus	78-99
12490007-7	2002	In parallel to elevating MABP and CPP, rCBF was significantly increased by norepinephrine and dopamine, being mostly pronounced with norepinephrine (+44% vs. +29%).	Norepinephrine	75-89	CCAAT/enhancer binding protein zeta	Rattus norvegicus	39-43
12145319-5	2002	The amisyn coil domain prevents the SNAP-25 C-terminally mediated rescue of botulinum neurotoxin E inhibition of norepinephrine exocytosis in permeabilized PC12 cells to a greater extent than it prevents the regular exocytosis of these vesicles.	Norepinephrine	113-127	syntaxin binding protein 6	Rattus norvegicus	4-10
7966997-7	1994	Plasma norepinephrine levels increased significantly at maximal workload in STE patients, as compared to the other groups.	Norepinephrine	7-21	sulfotransferase family 1E member 1	Homo sapiens	76-79
16878403-1	2006	Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine.	Norepinephrine	108-122	catechol-O-methyltransferase	Homo sapiens	0-28
16878403-1	2006	Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine.	Norepinephrine	108-122	catechol-O-methyltransferase	Homo sapiens	30-34
8076685-1	1994	The addition of corticotropin-releasing factor (CRF) to molluscan hemocytes induces the release of biogenic amines (norepinephrine, epinephrine, dopamine), a phenomenon we have considered as an ancestral type of stress response [(1992) Gen. Comp.	Norepinephrine	116-130	corticotropin releasing hormone	Homo sapiens	16-46
16160864-10	2005	Using adipocytes from Ucp1(+/+) and Ucp1(-/-) mice, we showed that noradrenaline-mediated phosphorylation of AMPK does not require the presence or activity of UCP1.	Norepinephrine	67-80	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	22-26
16160864-10	2005	Using adipocytes from Ucp1(+/+) and Ucp1(-/-) mice, we showed that noradrenaline-mediated phosphorylation of AMPK does not require the presence or activity of UCP1.	Norepinephrine	67-80	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	36-40
8046459-6	1994	All norepinephrine-containing cell bodies in the brainstem (locus coeruleus and lateral tegmentum) appear to express NET mRNA.	Norepinephrine	4-18	solute carrier family 6 member 2	Rattus norvegicus	117-120
7915614-10	1994	beta 2-Adrenoceptor-mediated relaxation responses to isoprenaline of the pulmonary artery, constricted with noradrenaline (6 x 10(-8) M), showed no significant difference in maximum response or EC50 in tissue from isoprenaline- or dopexamine-infused rats compared with vehicle-infused controls.	Norepinephrine	108-121	adrenoceptor beta 2	Rattus norvegicus	0-19
8132438-1	1994	Neuropeptide Y (NPY) is widely distributed throughout sympathetic nerve endings where it is co-stored and co-secreted with noradrenaline.	Norepinephrine	123-136	neuropeptide Y	Homo sapiens	0-14
16176450-2	2005	2 The alpha(1D)-adrenoceptor is involved in the contractile response to noradrenaline in wild type (WT) mouse aorta.	Norepinephrine	72-85	adrenergic receptor, alpha 1d	Mus musculus	6-28
15878998-8	2005	Norepinephrine reduced tone in the alpha(1D)-adrenoceptor knockout and controls, an effect blocked by rauwolscine and L-NAME but not by prazosin.	Norepinephrine	0-14	adrenergic receptor, alpha 1d	Mus musculus	35-57
15701815-0	2005	Calmodulin mediates norepinephrine-induced receptor-operated calcium entry in preglomerular resistance arteries.	Norepinephrine	20-34	calmodulin 1	Rattus norvegicus	0-10
8132438-1	1994	Neuropeptide Y (NPY) is widely distributed throughout sympathetic nerve endings where it is co-stored and co-secreted with noradrenaline.	Norepinephrine	123-136	neuropeptide Y	Homo sapiens	16-19
7906468-2	1993	Diethyldithiocarbamate, a dopamine-beta-hydroxylase inhibitor, reduces norepinephrine synthesis and acutely inhibits growth hormone (GH) secretion.	Norepinephrine	71-85	dopamine beta-hydroxylase	Rattus norvegicus	26-51
16004579-7	2005	Intravenous infusion of verapamil (VE; 200 microg/kg/min), and norepinephrine (NE; 20 microg/mL/min) to maintain normal blood pressure, increased rCBF by 141.5% at the primary injury site when compared to untreated, FPinjured animals.	Norepinephrine	63-77	CCAAT/enhancer binding protein zeta	Rattus norvegicus	146-150
8245983-5	1993	The rank order for substrate inhibition of [3H]5-HT uptake for both the previously reported rat vMAT1 and the human transporter clone followed the order 5-HT &gt; dopamine &gt; epinephrine &gt; norepinephrine &gt; 1-methyl-4-phenylpyridinium &gt; 2-phenylethylamine &gt; histamine.	Norepinephrine	194-208	solute carrier family 18 member A1	Rattus norvegicus	96-101
15900225-1	2005	OBJECTIVES: Catechol-O-methyltransferase plays a central role in the metabolism of biogenic amines such as norepinephrine, dopamine and serotonin.	Norepinephrine	107-121	catechol-O-methyltransferase	Homo sapiens	12-40
8143898-7	1993	Following preoptic treatment with 5"-ADMP, which depletes selectively norepinephrine (NE), GnRH mRNA level was significantly reduced.	Norepinephrine	70-84	gonadotropin releasing hormone 1	Rattus norvegicus	91-95
15795312-9	2005	Collectively, our data suggest that (a) RyRs play an important role in submaximal noradrenaline- and hypoxia-induced Ca2+ release and contraction; (b) all three subtype RyRs are expressed; and (c) RyR3 gene knockout significantly inhibits hypoxia-, but not submaximal noradrenaline-induced Ca2+ and contractile responses in PASMCs.	Norepinephrine	82-95	ryanodine receptor 3	Rattus norvegicus	197-201
7902747-4	1993	Analysis of the individual metabolites of inositol phospholipid metabolism formed in response to noradrenaline in PKC-depleted astrocytes revealed potentiated accumulations of radiolabelled glycerophosphoinositol (GPI), inositol monophosphate (IP1) and inositol bisphosphate (IP2) but not inositol trisphosphate (IP3) when compared to controls.	Norepinephrine	97-110	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	244-247
15618033-7	2005	The intra-group correlation between MMP-2 and noradrenaline was significant (r=0.33, P=0.01); indeed, noradrenaline appear to be a predictor of MMP-2.	Norepinephrine	102-115	matrix metallopeptidase 2	Homo sapiens	144-149
15618033-9	2005	CONCLUSIONS: The positive correlation between noradrenaline and MMP-2 in severe CHF patients, together with the in vitro induction of MMP-2 by this catecholamine, suggests a potential biochemical link between noradrenaline and MMP-2.	Norepinephrine	46-59	matrix metallopeptidase 2	Homo sapiens	64-69
7694282-3	1993	Since the release of luteinizing hormone-releasing hormone (LHRH) is also driven by norepinephrine and prostaglandin E2, we hypothesized that NO might also control pulsatile release of LHRH in vivo, resulting in turn in pulsatile release of luteinizing hormone (LH).	Norepinephrine	84-98	gonadotropin releasing hormone 1	Rattus norvegicus	21-58
15618033-9	2005	CONCLUSIONS: The positive correlation between noradrenaline and MMP-2 in severe CHF patients, together with the in vitro induction of MMP-2 by this catecholamine, suggests a potential biochemical link between noradrenaline and MMP-2.	Norepinephrine	209-222	matrix metallopeptidase 2	Homo sapiens	64-69
15618033-9	2005	CONCLUSIONS: The positive correlation between noradrenaline and MMP-2 in severe CHF patients, together with the in vitro induction of MMP-2 by this catecholamine, suggests a potential biochemical link between noradrenaline and MMP-2.	Norepinephrine	209-222	matrix metallopeptidase 2	Homo sapiens	134-139
15618033-9	2005	CONCLUSIONS: The positive correlation between noradrenaline and MMP-2 in severe CHF patients, together with the in vitro induction of MMP-2 by this catecholamine, suggests a potential biochemical link between noradrenaline and MMP-2.	Norepinephrine	209-222	matrix metallopeptidase 2	Homo sapiens	134-139
15582720-1	2005	The aim of the present study was to assess whether calcitonin gene-related peptide (CGRP) modulates exocytotic norepinephrine release in ischemic myocardium.	Norepinephrine	111-125	calcitonin-related polypeptide alpha	Rattus norvegicus	84-88
15663891-1	2005	AIM: To investigate the effects of orexin A on release of histamine, norepinephrine, and serotonin in the frontal cortex of mice.	Norepinephrine	69-83	hypocretin	Mus musculus	35-43
15663891-8	2005	CONCLUSION: These results suggest that the arousal effect of orexin A is mainly mediated by histamine, not by norepinephrine or serotonin.	Norepinephrine	110-124	hypocretin	Mus musculus	61-69
15726019-0	2005	Norepinephrine attenuates hypoxia-inhibited thyrotropin-releasing hormone release in median eminence and paraventricular nucleus of rat hypothalamus.	Norepinephrine	0-14	thyrotropin releasing hormone	Rattus norvegicus	44-73
15726019-2	2005	This study presented the effects of hypoxia on TRH secretion in rat hypothalamus, and the norepinephrine (NE) involvement in the modulation of TRH secretion during acute hypoxia exposure.	Norepinephrine	90-104	thyrotropin releasing hormone	Rattus norvegicus	143-146
15573400-11	2005	Moreover, a significant increase in MCT2 expression was observed in cultured neurons exposed to noradrenaline, an effect involving a regulation at the translational level.	Norepinephrine	96-109	solute carrier family 16 member 7	Rattus norvegicus	36-40
15588731-8	2004	The results show a significant increase in tyrosine hydroxylase levels and activity in the right and left ventricle 30 or 90 min after naloxone precipitated withdrawal in parallel with an increase in noradrenaline turnover.	Norepinephrine	200-213	tyrosine hydroxylase	Rattus norvegicus	43-63
15385622-4	2004	We found that catecholamines (l-3,4-hydroxyphenylalanine [l-dopa], dopamine, adrenaline, and noradrenaline) elevate FUS1 and RLM1 transcription.	Norepinephrine	93-106	Fus1p	Saccharomyces cerevisiae S288C	116-120
15385622-4	2004	We found that catecholamines (l-3,4-hydroxyphenylalanine [l-dopa], dopamine, adrenaline, and noradrenaline) elevate FUS1 and RLM1 transcription.	Norepinephrine	93-106	Rlm1p	Saccharomyces cerevisiae S288C	125-129
15542284-4	2004	These adrenoceptors are known to be located both pre-synaptically (alpha(2) and beta(2)) and post-synaptically (beta(1) and beta(2)), raising the possibility that their association with clinical measures in CHF could be mediated either by modulation of the cardiac response to a given level of adrenergic drive or by altering norepinephrine release from sympathetic nerve terminals.	Norepinephrine	326-340	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	80-88
15542284-4	2004	These adrenoceptors are known to be located both pre-synaptically (alpha(2) and beta(2)) and post-synaptically (beta(1) and beta(2)), raising the possibility that their association with clinical measures in CHF could be mediated either by modulation of the cardiac response to a given level of adrenergic drive or by altering norepinephrine release from sympathetic nerve terminals.	Norepinephrine	326-340	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	124-132
15286037-3	2004	The CGRP (10(-10) to 10(-7) M) produced a concentration-dependent relaxation of norepinephrine-induced contractions in mesenteric arteries of all groups.	Norepinephrine	80-94	calcitonin-related polypeptide alpha	Rattus norvegicus	4-8
12023879-3	2002	The lipolytic effect of noradrenaline was lowered by ectopic UCP1 in white adipocytes of aP2-Ucp1 transgenic mice, overexpressing the UCP1 gene from the aP2 gene promoter, reflecting the magnitude of UCP1 expression, the impaired stimulation of cAMP levels by noradrenaline and the reduction of the ATP/ADP ratio in different fat depots.	Norepinephrine	24-37	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	61-65
12023879-3	2002	The lipolytic effect of noradrenaline was lowered by ectopic UCP1 in white adipocytes of aP2-Ucp1 transgenic mice, overexpressing the UCP1 gene from the aP2 gene promoter, reflecting the magnitude of UCP1 expression, the impaired stimulation of cAMP levels by noradrenaline and the reduction of the ATP/ADP ratio in different fat depots.	Norepinephrine	24-37	transcription factor AP-2, alpha	Mus musculus	89-92
12023879-3	2002	The lipolytic effect of noradrenaline was lowered by ectopic UCP1 in white adipocytes of aP2-Ucp1 transgenic mice, overexpressing the UCP1 gene from the aP2 gene promoter, reflecting the magnitude of UCP1 expression, the impaired stimulation of cAMP levels by noradrenaline and the reduction of the ATP/ADP ratio in different fat depots.	Norepinephrine	24-37	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	93-97
12023879-3	2002	The lipolytic effect of noradrenaline was lowered by ectopic UCP1 in white adipocytes of aP2-Ucp1 transgenic mice, overexpressing the UCP1 gene from the aP2 gene promoter, reflecting the magnitude of UCP1 expression, the impaired stimulation of cAMP levels by noradrenaline and the reduction of the ATP/ADP ratio in different fat depots.	Norepinephrine	24-37	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	134-138
12023879-3	2002	The lipolytic effect of noradrenaline was lowered by ectopic UCP1 in white adipocytes of aP2-Ucp1 transgenic mice, overexpressing the UCP1 gene from the aP2 gene promoter, reflecting the magnitude of UCP1 expression, the impaired stimulation of cAMP levels by noradrenaline and the reduction of the ATP/ADP ratio in different fat depots.	Norepinephrine	24-37	transcription factor AP-2, alpha	Mus musculus	153-156
12023879-3	2002	The lipolytic effect of noradrenaline was lowered by ectopic UCP1 in white adipocytes of aP2-Ucp1 transgenic mice, overexpressing the UCP1 gene from the aP2 gene promoter, reflecting the magnitude of UCP1 expression, the impaired stimulation of cAMP levels by noradrenaline and the reduction of the ATP/ADP ratio in different fat depots.	Norepinephrine	24-37	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	134-138
12023879-3	2002	The lipolytic effect of noradrenaline was lowered by ectopic UCP1 in white adipocytes of aP2-Ucp1 transgenic mice, overexpressing the UCP1 gene from the aP2 gene promoter, reflecting the magnitude of UCP1 expression, the impaired stimulation of cAMP levels by noradrenaline and the reduction of the ATP/ADP ratio in different fat depots.	Norepinephrine	260-273	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	61-65
12040535-4	2002	These high concentrations are needed to induce the medullary enzyme, phenylethanolamine-N-methyltransferase (PNMT), which controls the synthesis of epinephrine from norepinephrine.	Norepinephrine	165-179	phenylethanolamine N-methyltransferase	Homo sapiens	69-107
12040535-4	2002	These high concentrations are needed to induce the medullary enzyme, phenylethanolamine-N-methyltransferase (PNMT), which controls the synthesis of epinephrine from norepinephrine.	Norepinephrine	165-179	phenylethanolamine N-methyltransferase	Homo sapiens	109-113
12061138-4	2002	Endogenous norepinephrine (NE) activates alpha 1-adrenoceptors to lead to the activation of protein kinase C (PKC), which, in turn, activates ecto-5"-nucleotidase via phosphorylation, thereby enhancing the production of interstitial adenosine.	Norepinephrine	11-25	5' nucleotidase, ecto	Rattus norvegicus	142-162
12422533-2	2002	MEP induced relaxation in aorta precontracted with noradrenaline (10(-6) M) or KCl (80 mM) (IC50 = 14.49 +/- 1.15 and 5.93 +/- 1.26 micrograms/mL, respectively) in a dose-dependent manner and this relaxant effect was not endothelium-dependent.	Norepinephrine	51-64	neurolysin	Rattus norvegicus	0-3
11952783-12	2002	In the subject homozygous for AQPap-G264V, exercise-induced increase in plasma glycerol was not observed in spite of the increased plasma noradrenaline.	Norepinephrine	138-151	aquaporin 7	Homo sapiens	30-35
7694282-3	1993	Since the release of luteinizing hormone-releasing hormone (LHRH) is also driven by norepinephrine and prostaglandin E2, we hypothesized that NO might also control pulsatile release of LHRH in vivo, resulting in turn in pulsatile release of luteinizing hormone (LH).	Norepinephrine	84-98	gonadotropin releasing hormone 1	Rattus norvegicus	60-64
7694282-3	1993	Since the release of luteinizing hormone-releasing hormone (LHRH) is also driven by norepinephrine and prostaglandin E2, we hypothesized that NO might also control pulsatile release of LHRH in vivo, resulting in turn in pulsatile release of luteinizing hormone (LH).	Norepinephrine	84-98	gonadotropin releasing hormone 1	Rattus norvegicus	185-189
7694282-8	1993	Incubation of medial basal hypothalami with norepinephrine (10 microM) induced an increase in LHRH release that was inhibited by NMMA (300 microM).	Norepinephrine	44-58	gonadotropin releasing hormone 1	Rattus norvegicus	94-98
7694282-13	1993	The combined in vivo and in vitro results indicate that the pulsatile release of LHRH induced by norepinephrine is brought about by alpha 1-adrenergic activation of NO synthase.	Norepinephrine	97-111	gonadotropin releasing hormone 1	Rattus norvegicus	81-85
8276080-7	1993	The facilitation of the evoked overflow of both noradrenaline and adrenaline was blocked by the selective beta 2-adrenoceptor antagonist, ICI 118,551 (0.3 mg/kg).	Norepinephrine	48-61	adrenoceptor beta 2	Rattus norvegicus	106-125
8280187-2	1993	Previous studies show that native LDL immediately and reversibly inhibit acetylcholine-evoked EDRF responses in rabbit aortic ring precontracted with noradrenaline or serotonin whereas Cu(2+)-oxidised LDL (oxLDL) inhibit relaxations after 30 min with a potency that varies with the donor.	Norepinephrine	150-163	alpha hemoglobin stabilizing protein	Homo sapiens	94-98
11834628-0	2002	Comparison of the ORL1 receptor-mediated inhibition of noradrenaline release in human and rat neocortical slices.	Norepinephrine	55-68	opioid related nociceptin receptor 1	Homo sapiens	18-22
15375008-4	2004	Short-term (10-minute) and sustained (24-hour) beta1AR stimulation with norepinephrine similarly enhanced cell contraction and Ca2+ transients, in contrast to anticipated receptor desensitization.	Norepinephrine	72-86	adrenoceptor beta 1	Homo sapiens	47-54
15342279-0	2004	Leptin inhibits norepinephrine efflux from the hypothalamus in vitro: role of gamma aminobutyric acid.	Norepinephrine	16-30	leptin	Rattus norvegicus	0-6
15342279-2	2004	Hypothalamic norepinephrine (NE) is involved in many of the neuroendocrine effects that are associated with leptin.	Norepinephrine	13-27	leptin	Rattus norvegicus	108-114
15262904-0	2004	Reduction of vascular noradrenaline sensitivity by AT1 antagonists depends on functional sympathetic innervation.	Norepinephrine	22-35	angiotensin II receptor, type 1a	Rattus norvegicus	51-54
15262904-1	2004	Blockade of angiotensin II type-1 (AT1) receptors has been shown to reduce the magnitude of the blood pressure response to noradrenaline in pithed rats via an unidentified mechanism.	Norepinephrine	123-136	angiotensin II receptor, type 1a	Rattus norvegicus	35-38
15262904-8	2004	Our experiments show that the reduction of vascular noradrenaline sensitivity by AT1 blockade is dependent on the intact functioning of both neuronal noradrenaline uptake via norepinephrine transporter and presynaptic alpha2-mediated autoinhibition, exclusively provided by the sympathetic innervation.	Norepinephrine	52-65	angiotensin II receptor, type 1a	Rattus norvegicus	81-84
15262904-8	2004	Our experiments show that the reduction of vascular noradrenaline sensitivity by AT1 blockade is dependent on the intact functioning of both neuronal noradrenaline uptake via norepinephrine transporter and presynaptic alpha2-mediated autoinhibition, exclusively provided by the sympathetic innervation.	Norepinephrine	150-163	angiotensin II receptor, type 1a	Rattus norvegicus	81-84
15233745-5	2004	The number of neurons positive for tyrosine hydroxylase (TH) mRNA, the rate-limiting enzyme of noradrenaline synthesis, is reduced to a smaller degree and expression levels are not detectably altered.	Norepinephrine	95-108	tyrosine hydroxylase	Mus musculus	35-55
14759557-1	2004	Based upon the existence of high density of ET-receptors on catecholaminergic neurons of the hypothalamus, we studied the effects of endothelin-1 (ET-1) and endothelin-3 (ET-3) on neuronal norepinephrine (NE) release in the rat posterior hypothalamus.	Norepinephrine	189-203	endothelin 3	Rattus norvegicus	171-175
14980979-15	2004	The present study has shown a predominant role of the alpha(1A)-adrenoceptor in contractions due to exogenous noradrenaline and to neurally released noradrenaline in rat femoral resistance arteries.	Norepinephrine	110-123	adrenoceptor alpha 1A	Rattus norvegicus	54-76
14980979-15	2004	The present study has shown a predominant role of the alpha(1A)-adrenoceptor in contractions due to exogenous noradrenaline and to neurally released noradrenaline in rat femoral resistance arteries.	Norepinephrine	149-162	adrenoceptor alpha 1A	Rattus norvegicus	54-76
14752233-1	2004	The purpose of this study was to investigate mechanisms of suppression of norepinephrine release by 7-OH-DPAT, a dopamine D(2)/D(3) receptor agonist, in PC12 cells pretreated with nerve growth factor (NGF).	Norepinephrine	74-88	nerve growth factor	Rattus norvegicus	180-199
14752233-1	2004	The purpose of this study was to investigate mechanisms of suppression of norepinephrine release by 7-OH-DPAT, a dopamine D(2)/D(3) receptor agonist, in PC12 cells pretreated with nerve growth factor (NGF).	Norepinephrine	74-88	nerve growth factor	Rattus norvegicus	201-204
11882582-8	2002	The abrogating effects of quercetin and OR486 on the metabolism and antimitogenic effects of 2-hydroxyestradiol were mimicked by 20 micromol/L norepinephrine and isoproterenol, substrates for COMT.	Norepinephrine	143-157	catechol-O-methyltransferase	Homo sapiens	192-196
8223568-4	1993	In isolated rat hepatocytes PGF2 alpha, noradrenaline and glucagon activated glycogen phosphorylase but only PGF2 alpha and noradrenaline increased intracellular inositol 1,4,5-trisphosphate (InsP3).	Norepinephrine	40-53	glycogen phosphorylase L	Rattus norvegicus	77-99
11859855-6	2002	Evidence also has been presented to indicate that nicotine acts on alpha7-nicotinic receptors located on sympathetic nerve terminals, resulting in release of norepinephrine which then diffuses to act on beta2-adrenoceptos located on the neighboring nitrergic nerve terminals to release NO and therefore vasodilation.	Norepinephrine	158-172	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	203-208
8223568-5	1993	The noradrenaline- or PGF2 alpha-elicited activation of glycogen phosphorylase and increase in InsP3 were largely reduced after preincubation of the cells for 10 min with PMA, whereas the glucagon-mediated enzyme activation was not affected.	Norepinephrine	4-17	glycogen phosphorylase L	Rattus norvegicus	56-78
7687716-1	1993	Neuropeptide Y (NPY), a potent vasoconstrictor agent reported to be released, in addition to norepinephrine (NE), by sympathetic nerve endings during stress, may contribute to the pressor response to various stimuli.	Norepinephrine	93-107	neuropeptide Y	Homo sapiens	0-14
11746719-1	2001	It was previously shown that the excitatory effect of the 5-HT(1A) agonist 8-OH-DPAT on firing activity of locus coeruleus (LC) norepinephrine (NE) neurons and the inhibitory action of the 5-HT(1A) antagonist WAY 100,635 are dependent on the presence of 5-HT neurons, whereas the inhibitory action of the 5-HT(2) agonist DOI is not.	Norepinephrine	128-142	5-hydroxytryptamine receptor 1A	Rattus norvegicus	58-65
7687716-1	1993	Neuropeptide Y (NPY), a potent vasoconstrictor agent reported to be released, in addition to norepinephrine (NE), by sympathetic nerve endings during stress, may contribute to the pressor response to various stimuli.	Norepinephrine	93-107	neuropeptide Y	Homo sapiens	16-19
8102190-2	1993	Neuropeptide Y (NPY), consisting of 36 amino acids, has been reported to coexist usually with noradrenaline in peripheral sympathetic neurons.	Norepinephrine	94-107	neuropeptide Y	Homo sapiens	0-14
11592955-0	2001	Role of COX-2-derived metabolites in regulation of the renal hemodynamic response to norepinephrine.	Norepinephrine	85-99	cytochrome c oxidase subunit II	Canis lupus familiaris	8-13
15259379-6	2004	BNP was positively related to age, NYHA class, IL-6, TNF-alpha, adrenaline, noradrenaline and cortisol, while negatively with ejection fraction and FT3.	Norepinephrine	76-89	natriuretic peptide B	Homo sapiens	0-3
14717702-1	2004	GTP cyclohydrolase I (GCH) is the rate-limiting enzyme for the synthesis of tetrahydrobiopterin and its activity is important in the regulation of monoamine neurotransmitters such as dopamine, norepinephrine and serotonin.	Norepinephrine	193-207	GTP cyclohydrolase 1	Homo sapiens	0-20
14717702-1	2004	GTP cyclohydrolase I (GCH) is the rate-limiting enzyme for the synthesis of tetrahydrobiopterin and its activity is important in the regulation of monoamine neurotransmitters such as dopamine, norepinephrine and serotonin.	Norepinephrine	193-207	GTP cyclohydrolase 1	Homo sapiens	22-25
15143490-3	2004	Phentolamine, prazosin eliminated the simulative effect of TRH, yohimbine resulted in additional gain of effect, which seems to testify 1) presynaptic action of TRH or 2) increase of the output of norepinephrine, which is potentiated by alpha 2-adrenoceptor antagonists.	Norepinephrine	197-211	thyrotropin releasing hormone	Rattus norvegicus	59-62
12907448-5	2003	However, in circulating chicken embryonic RBCs, the enzyme is induced together with carbonic anhydrase (CAII) and 2,3-bisphosphoglycerate (2,3-BPG) by norepinephrine (NE) and adenosine, which are released by the embryo under hypoxic conditions.	Norepinephrine	151-165	carbonic anhydrase 2	Gallus gallus	104-108
8102190-2	1993	Neuropeptide Y (NPY), consisting of 36 amino acids, has been reported to coexist usually with noradrenaline in peripheral sympathetic neurons.	Norepinephrine	94-107	neuropeptide Y	Homo sapiens	16-19
8102190-7	1993	Present study revealed that NPY might be a possible neuromodulator in lower urinary tract, cooperating with noradrenaline.	Norepinephrine	108-121	neuropeptide Y	Homo sapiens	28-31
8496832-1	1993	Neuropeptide Y (NPY) coexists and is coreleased with norepinephrine (NE) from postganglionic sympathetic nerves.	Norepinephrine	53-67	neuropeptide Y	Oryctolagus cuniculus	0-14
8496832-1	1993	Neuropeptide Y (NPY) coexists and is coreleased with norepinephrine (NE) from postganglionic sympathetic nerves.	Norepinephrine	53-67	neuropeptide Y	Oryctolagus cuniculus	16-19
8510498-1	1993	Dopamine beta-hydroxylase (DBH, EC 1.14.17.1) catalyzes the conversion of dopamine to norepinephrine, the third step of catecholamine biosynthesis.	Norepinephrine	86-100	dopamine beta-hydroxylase	Homo sapiens	0-25
8510498-1	1993	Dopamine beta-hydroxylase (DBH, EC 1.14.17.1) catalyzes the conversion of dopamine to norepinephrine, the third step of catecholamine biosynthesis.	Norepinephrine	86-100	dopamine beta-hydroxylase	Homo sapiens	27-30
8473003-7	1993	In the substantia nigra of rats fed 10 ppm T-2, epinephrine increased after 7 days and norepinephrine decreased after 14 days, when compared with controls.	Norepinephrine	87-101	brachyury 2	Rattus norvegicus	43-46
8382264-1	1993	Administration of carbachol, noradrenaline, and bradykinin induced Egr-1 mRNA expression within 1 h in mouse neuroblastoma x rat glioma hybrid NG108-15 cells.	Norepinephrine	29-42	early growth response 1	Mus musculus	67-72
12972630-1	2003	In rabbit portal vein myocytes noradrenaline activates a non-selective cation current (Icat) which involves a transient receptor potential protein (TRPC6).	Norepinephrine	31-44	short transient receptor potential channel 6	Oryctolagus cuniculus	148-153
14727518-0	2003	[Possible involvement of IGF-1 receptor and IGF-binding protein in insulin-induced enhancement of noradrenaline response in diabetic rat aorta].	Norepinephrine	98-111	insulin-like growth factor 1 receptor	Rattus norvegicus	25-39
14500754-7	2003	Receptor function measured with the [3H]norepinephrine release assay was measurable in both nicotine-treated and NGF-treated cells; however, cytisine-stimulated [3H]norepinephrine release indicated that nicotine treatment increased an nAChR containing beta2 subunits, whereas NGF increased a receptor containing beta4 subunits.	Norepinephrine	40-54	nerve growth factor	Rattus norvegicus	113-116
12768272-4	2003	METHODS: The extracellular noradrenaline level within the CeA during naloxone-precipitated morphine withdrawal was measured using an in vivo microdialysis experiment on unanesthetized and freely moving rats.	Norepinephrine	27-40	carcinoembryonic antigen gene family 4	Rattus norvegicus	58-61
12768272-6	2003	RESULTS: The extracellular noradrenaline level within the CeA was transiently elevated during morphine withdrawal.	Norepinephrine	27-40	carcinoembryonic antigen gene family 4	Rattus norvegicus	58-61
12972688-9	2003	These results also indicate the possibility that Zn ions may regulate physiologically the level of serotonin and norepinephrine content in brain by inhibiting a MAO-A activity.	Norepinephrine	113-127	monoamine oxidase A	Rattus norvegicus	161-166
12970076-0	2003	Lack of CB1 receptors increases noradrenaline release in vas deferens without affecting atrial noradrenaline release or cortical acetylcholine release.	Norepinephrine	32-45	cannabinoid receptor 1 (brain)	Mus musculus	8-11
12970107-0	2003	Possible involvement of IGF-1 receptor and IGF-binding protein in insulin-induced enhancement of noradrenaline response in diabetic rat aorta.	Norepinephrine	97-110	insulin-like growth factor 1 receptor	Rattus norvegicus	24-38
12858360-0	2003	Norepinephrine activates P44 and P42 MAPK in human prostate stromal and smooth muscle cells but not in epithelial cells.	Norepinephrine	0-14	interferon induced protein 44	Homo sapiens	25-28
12878372-2	2003	This has been attributed to blockade of AT1 receptors located presynaptically on sympathetic nerve endings normally facilitating norepinephrine release.	Norepinephrine	129-143	angiotensin II receptor type 1	Homo sapiens	40-43
12890778-1	2003	Thealpha2C subclass of adrenergic receptor (alpha2C-AR) mediates some of the antinociceptive actions of norepinephrine in the spinal cord.	Norepinephrine	104-118	adrenoceptor alpha 2C	Rattus norvegicus	44-54
12906036-0	2003	Norepinephrine-induced inositol 1,4,5-trisphosphate formation in atrial myocytes is regulated by extracellular calcium, protein kinase C, and calmodulin.	Norepinephrine	0-14	calmodulin 1	Rattus norvegicus	142-152
12606673-0	2003	Norepinephrine evoked by potassium depolarization increases interstitial adenosine concentration via activation of ecto-5"-nucleotidase in rat hearts.	Norepinephrine	0-14	5' nucleotidase, ecto	Rattus norvegicus	115-135
11641129-2	2001	Infusion of PACAP (100 nM) increased adrenal epinephrine and norepinephrine output.	Norepinephrine	61-75	adenylate cyclase activating polypeptide 1	Rattus norvegicus	12-17
11684074-1	2001	OBJECTIVE: In this study we have tested the hypothesis that degradation of collagen by matrix metalloproteinase 2 (MMP-2) precedes the deposition of extracellular matrix (ECM) after long term norepinephrine (NE) treatment.	Norepinephrine	192-206	matrix metallopeptidase 2	Rattus norvegicus	87-113
11684074-1	2001	OBJECTIVE: In this study we have tested the hypothesis that degradation of collagen by matrix metalloproteinase 2 (MMP-2) precedes the deposition of extracellular matrix (ECM) after long term norepinephrine (NE) treatment.	Norepinephrine	192-206	matrix metallopeptidase 2	Rattus norvegicus	115-120
11443056-5	2001	Other agonists including norepinephrine, serotonin, histamine, and endothelin-1 (ET-1) also stimulated RhoA, albeit to lesser extents than U-46619.	Norepinephrine	25-39	transforming protein RhoA	Oryctolagus cuniculus	103-107
11448853-1	2001	We elucidated the functional contribution of voltage-dependent calcium channels (VDCCs) and adenylate cyclase to epinephrine (Epi) and norepinephrine (NE) secretion induced by pituitary adenylate cyclase-activating polypeptide (PACAP) in the isolated perfused rat adrenal gland.	Norepinephrine	135-149	adenylate cyclase activating polypeptide 1	Rattus norvegicus	176-226
11443533-1	2001	The synaptic vesicular monoamine transporter (SVMT), alternatively vesicular monoamine transporter 2 (VMAT2), pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles.	Norepinephrine	157-171	solute carrier family 18 member A2	Homo sapiens	4-44
11443533-1	2001	The synaptic vesicular monoamine transporter (SVMT), alternatively vesicular monoamine transporter 2 (VMAT2), pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles.	Norepinephrine	157-171	solute carrier family 18 member A2	Homo sapiens	46-50
11443533-1	2001	The synaptic vesicular monoamine transporter (SVMT), alternatively vesicular monoamine transporter 2 (VMAT2), pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles.	Norepinephrine	157-171	solute carrier family 18 member A2	Homo sapiens	67-100
11443533-1	2001	The synaptic vesicular monoamine transporter (SVMT), alternatively vesicular monoamine transporter 2 (VMAT2), pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles.	Norepinephrine	157-171	solute carrier family 18 member A2	Homo sapiens	102-107
11411741-1	2001	Converting enzyme inhibition and angiotensin II receptor antagonism attenuate elevations in heart rate and plasma norepinephrine in response to insulin, suggesting that integrity of the renin-angiotensin system is necessary for insulin-induced sympathoexcitation.	Norepinephrine	114-128	renin	Rattus norvegicus	186-191
8382264-2	1993	With specific receptor antagonists, the Egr-1 inductions by carbachol and noradrenaline were shown to be mediated via cholinergic muscarinic and alpha 2-adrenergic receptors, respectively.	Norepinephrine	74-87	early growth response 1	Mus musculus	40-45
8382264-5	1993	On the other hand, bradykinin consistently had an additive effect on Egr-1 induction, irrespective of the time of its addition, suggesting that the signal pathways for Egr-1 induction by carbachol or noradrenaline and by bradykinin are different.	Norepinephrine	200-213	early growth response 1	Mus musculus	168-173
8382264-6	1993	Treatment of cells with pertussis toxin or cholera toxin strongly inhibited Egr-1 induction by carbachol or noradrenaline but only partially inhibited the induction by bradykinin.	Norepinephrine	108-121	early growth response 1	Mus musculus	76-81
8443037-8	1993	Thus, neurotransmitters in the central nervous system which are substrate for MAO-A (i.e. noradrenaline, 5-HT) may be involved in the control of capsaicin-induced reflex bronchoconstriction.	Norepinephrine	90-103	monoamine oxidase A	Homo sapiens	78-83
11376117-6	2001	Forskolin, norepinephrine, and dopamine, all of which stimulate cAMP production in GT1 cells, each increased the frequency of Ca(2+) oscillations.	Norepinephrine	11-25	myosin light chain 4	Homo sapiens	83-86
11534803-1	2001	BACKGROUND: The present work aimed to study the changes of both norepinephrine (NE) and dopamine-beta-hydroxylase (DbetaH) in pregnancy-induced hypertension (PIH).	Norepinephrine	64-78	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	158-161
11273730-2	2001	Norepinephrine (NE; 1 microM) in the presence of the beta -AR antagonist propranolol (Pro; 2 microM) caused activation of Ras (&gt;six-fold), MAPK/ERK kinase 1 and 2 (MEK1/2, &gt;10-fold) and extracellular signal-regulated kinases 1 and 2 (ERK1/2, approximately 30-fold) within 5 min, as determined by kinase activity assays and Western blots using phospho-specific antibodies.	Norepinephrine	0-14	mitogen activated protein kinase kinase 1	Rattus norvegicus	167-173
11273730-2	2001	Norepinephrine (NE; 1 microM) in the presence of the beta -AR antagonist propranolol (Pro; 2 microM) caused activation of Ras (&gt;six-fold), MAPK/ERK kinase 1 and 2 (MEK1/2, &gt;10-fold) and extracellular signal-regulated kinases 1 and 2 (ERK1/2, approximately 30-fold) within 5 min, as determined by kinase activity assays and Western blots using phospho-specific antibodies.	Norepinephrine	0-14	mitogen activated protein kinase 3	Rattus norvegicus	192-238
11273730-2	2001	Norepinephrine (NE; 1 microM) in the presence of the beta -AR antagonist propranolol (Pro; 2 microM) caused activation of Ras (&gt;six-fold), MAPK/ERK kinase 1 and 2 (MEK1/2, &gt;10-fold) and extracellular signal-regulated kinases 1 and 2 (ERK1/2, approximately 30-fold) within 5 min, as determined by kinase activity assays and Western blots using phospho-specific antibodies.	Norepinephrine	0-14	mitogen activated protein kinase 3	Rattus norvegicus	240-246
11245920-2	2001	In the present study, we tested the hypothesis that inhibition of catecholamine metabolism with the MAO-A inhibitor, clorgyline, might enhance cocaine-induced increases in extracellular dopamine and norepinephrine in rat nucleus accumbens.	Norepinephrine	199-213	monoamine oxidase A	Rattus norvegicus	100-105
12646175-5	2003	The neurotransmitters, which were implicated in sleep/wake regulation, affected the activity of orexin neurons; noradrenaline and serotonin hyperpolarized, while carbachol depolarized orexin neurons in either the presence or absence of tetrodotoxin.	Norepinephrine	112-125	hypocretin	Mus musculus	96-102
12605405-2	2003	We used transgenic Tg8 mice knockout for the MAO-A (monoamine oxidase A) gene, which are characterized by increased amounts of serotonin and noradrenaline in brain compared to wild-type mice (C3H).	Norepinephrine	141-154	monoamine oxidase A	Mus musculus	45-50
12605405-2	2003	We used transgenic Tg8 mice knockout for the MAO-A (monoamine oxidase A) gene, which are characterized by increased amounts of serotonin and noradrenaline in brain compared to wild-type mice (C3H).	Norepinephrine	141-154	monoamine oxidase A	Mus musculus	52-71
12605405-5	2003	Inhibiting serotonin or noradrenaline synthesis in Tg8 mice by the administration of parachlorophenylalanine or alpha-methylparatyrosine, respectively, the amounts of AVP, VIP and their mRNAs were decreased, but not the number of peptidergic neurons.	Norepinephrine	24-37	arginine vasopressin	Mus musculus	167-170
12605405-6	2003	This study indicates that serotonin and noradrenaline stimulate AVP and VIP expression, and could participate in the differentiation of the neurochemical phenotype in the mouse SCN.	Norepinephrine	40-53	arginine vasopressin	Mus musculus	64-67
8094272-7	1993	In addition to this study, the alpha 1-, alpha 2-, beta 1-, beta 2-, and beta 3-agonists norepinephrine and epinephrine were infused with simultaneous infusion of the beta 1- and beta 2-blocker propranolol.	Norepinephrine	89-103	adrenoceptor alpha 1D	Homo sapiens	31-79
12644001-0	2003	Hypoxia, angiotensin-II, and norepinephrine mediated apoptosis is stimulus specific in canine failed cardiomyocytes: a role for p38 MAPK, Fas-L and cyclin D1.	Norepinephrine	29-43	Fas ligand	Canis lupus familiaris	138-143
12644001-3	2003	AIMS: We tested the hypothesis that hypoxia (HX), angiotensin-II (A-II) and norepinephrine (NEPI) can mediate apoptosis by activating p38 MAPK, and thus initiating stimulus specific changes in Fas-L and cyclin D(1) expression in failing cardiomyocytes.	Norepinephrine	76-90	Fas ligand	Canis lupus familiaris	193-198
12578963-9	2003	Only noradrenaline resulted in a dose- and time-dependent induction of NF-kappaB and NF-kappaB-dependent gene expression, which depended on pertussis-toxin-sensitive G protein-mediated phosphophatidylinositol 3-kinase, Ras/Raf, and mitogen-activated protein kinase activation.	Norepinephrine	5-18	zinc fingers and homeoboxes 2	Homo sapiens	223-226
12524145-0	2003	Prostanoid EP3 and TP receptors-mediated inhibition of noradrenaline release from the isolated rat stomach.	Norepinephrine	55-68	prostaglandin E receptor 3	Rattus norvegicus	11-14
7922157-2	1993	Neuropeptide Y is co-released with noradrenaline by perivascular nerve endings.	Norepinephrine	35-48	neuropeptide Y	Homo sapiens	0-14
8432288-3	1993	In both normal and heart failure patients, NPY-Li-decreased (296 +/- 73 to 233 +/- 63 pg.ml-1 and 652 +/- 36 to 516 +/- 25 pg.ml-1 (P &lt; 0.01) respectively) in response to standing, whereas catecholamines increased in both groups (norepinephrine 203 +/- 73 to 507 +/- 165 pg.ml-1 and 493 +/- 197 to 813 +/- 336 pg.ml-1 (P &lt; 0.001) respectively and epinephrine 23 +/- 12 to 38 +/- 12 pg.ml-1 and 46 +/- 19 to 62 +/- 28 pg.ml-1 (P &lt; 0.001) respectively).	Norepinephrine	233-247	neuropeptide Y	Homo sapiens	43-46
12648529-4	2003	To elucidate whether G(h) mediates norepinephrine-stimulated intracellular signal transductions leading to activation of extracellular signal-regulated kinases (ERKs) and neonatal rat cardiomyocyte hypertrophy, we examined the effects of G(h) on the activation of ERKs and inhibitory effects of CRT on alpha(1)-adrenoceptor/G(h) signaling.	Norepinephrine	35-49	mitogen activated protein kinase 3	Rattus norvegicus	161-165
12648529-5	2003	In neonatal rat cardiomyocytes, norepinephrine-induced ERKs activation was inhibited by an alpha(1)-adrenoceptor blocker (prazosin), but not by an beta-adrenoceptor blocker (propranolol).	Norepinephrine	32-46	mitogen activated protein kinase 3	Rattus norvegicus	55-59
12648529-6	2003	Overexpression of the G(h) protein stimulated norepinephrine-induced ERKs activation, which was inhibited by alpha-adrenoceptor blocker (prazosin).	Norepinephrine	46-60	mitogen activated protein kinase 3	Rattus norvegicus	69-73
12648529-7	2003	Co-overexpression of G(h) and CRT abolished norepinephrine-induced ERKs activation.	Norepinephrine	44-58	calreticulin	Rattus norvegicus	30-33
12648529-7	2003	Co-overexpression of G(h) and CRT abolished norepinephrine-induced ERKs activation.	Norepinephrine	44-58	mitogen activated protein kinase 3	Rattus norvegicus	67-71
12648529-8	2003	Taken together, norepinephrine induces hypertrophy in neonatal rat cardiomyocytes through alpha(1)-AR stimulation and G(h) is partly involved in norepinephrine-induced MEK1,2/ERKs activation.	Norepinephrine	145-159	mitogen activated protein kinase kinase 1	Rattus norvegicus	168-174
12648529-8	2003	Taken together, norepinephrine induces hypertrophy in neonatal rat cardiomyocytes through alpha(1)-AR stimulation and G(h) is partly involved in norepinephrine-induced MEK1,2/ERKs activation.	Norepinephrine	145-159	mitogen activated protein kinase 3	Rattus norvegicus	175-179
19912895-1	1992	The expression of proenkephalin (PENK) mRNA in C6 rat glioma cells was stimulated by norepinephrine (a beta-adrenergic agonist) and markedly enhanced by the addition of dexamethasone (a glucocorticoid agonist) to the culture medium, although dexamethasone alone exhibited no significant increase in PENK mRNA.	Norepinephrine	85-99	proenkephalin	Rattus norvegicus	18-31
12564841-0	2002	Assay of catechol-O-methyltransferase activity in human erythrocytes using norepinephrine as a natural substrate.	Norepinephrine	75-89	catechol-O-methyltransferase	Homo sapiens	9-37
12421355-5	2002	In the neurochemical study, noradrenaline and O-phosphoserine were decreased in the midbrain of the saline-treated histidine decarboxylase gene knockout mice.	Norepinephrine	28-41	histidine decarboxylase	Mus musculus	115-138
19912895-1	1992	The expression of proenkephalin (PENK) mRNA in C6 rat glioma cells was stimulated by norepinephrine (a beta-adrenergic agonist) and markedly enhanced by the addition of dexamethasone (a glucocorticoid agonist) to the culture medium, although dexamethasone alone exhibited no significant increase in PENK mRNA.	Norepinephrine	85-99	proenkephalin	Rattus norvegicus	33-37
1475406-3	1992	Neuropeptide Y (NPY) induces direct vasoconstriction and potentiates the action of noradrenaline.	Norepinephrine	83-96	neuropeptide Y	Homo sapiens	0-14
1475406-3	1992	Neuropeptide Y (NPY) induces direct vasoconstriction and potentiates the action of noradrenaline.	Norepinephrine	83-96	neuropeptide Y	Homo sapiens	16-19
1475406-5	1992	In order to determine if NPY could be involved in the enhanced vascular sensitivity to noradrenaline associated with adrenocortical hyperactivity, we measured plasma NPY in patients with Cushing"s syndrome (n = 26) and primary hyperaldosteronism (n = 15) and compared it with that of hypertensive patients with pheochromocytomas (n = 13) or essential hypertension (n = 51) and with normotensive controls (n = 47).	Norepinephrine	87-100	neuropeptide Y	Homo sapiens	25-28
12490007-7	2002	In parallel to elevating MABP and CPP, rCBF was significantly increased by norepinephrine and dopamine, being mostly pronounced with norepinephrine (+44% vs. +29%).	Norepinephrine	133-147	CCAAT/enhancer binding protein zeta	Rattus norvegicus	39-43
11239487-5	2001	Norepinephrine-induced thermogenesis in brown-fat cells is absolutely dependent on UCP1, as is the uncoupled state and the recoupling by purine nucleotides in isolated brown-fat mitochondria.	Norepinephrine	0-14	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	83-87
1488103-0	1992	Mechanisms of norepinephrine mediated corticotropin-releasing factor-41 release from cultured fetal hypothalamic cells.	Norepinephrine	14-28	corticotropin releasing hormone	Homo sapiens	38-71
11288486-6	2001	TH heterozygous mice showed a reduction of high K(+)-evoked noradrenaline release in the frontal cortex by the microdialysis technique and a reduction of cAMP of the brain cAMP content.	Norepinephrine	60-73	tyrosine hydroxylase	Mus musculus	0-2
12235241-0	2002	Role of adenosine A(1) receptor in angiotensin II- and norepinephrine-induced renal vasoconstriction.	Norepinephrine	55-69	adenosine A1 receptor	Canis lupus familiaris	8-31
12235258-4	2002	alpha(1a)-AR activation by norepinephrine increased the cytosolic Ca(2+) concentration and phosphorylated ERK1/2 in a time- and concentration-dependent manner.	Norepinephrine	27-41	mitogen-activated protein kinase 3	Mus musculus	106-112
12235258-8	2002	Norepinephrine-induced ERK1/2 phosphorylation was inhibited by the adenylyl cyclase activator forskolin and was enhanced by the adenylyl cyclase inhibitor 9-(tetrahydro-2-furanyl)-9H-purine-6-amine (SQ 22536) and the protein kinase A inhibitor 4-cyano-3-methylisoquinoline.	Norepinephrine	0-14	mitogen-activated protein kinase 3	Mus musculus	23-29
1359604-7	1992	CRH content in the locus coeruleus is particularly increased by stress and may influence norepinephrine neurotransmitter function in this structure.	Norepinephrine	89-103	corticotropin releasing hormone	Homo sapiens	0-3
12204768-4	2002	Endogenous norepinephrine (NE) activates both alpha(1)-adrenoceptors and protein kinase C (PKC), which, in turn, activates ecto-5"-nucleotidase via phosphorylation thereby enhancing the production of interstitial adenosine.	Norepinephrine	11-25	5' nucleotidase, ecto	Rattus norvegicus	123-143
12084707-7	2002	Additionally, Western blot analysis for phospho-CREB/ATF1 shows an increase in phosphorylation of CREB/ATF1 in HIB-1B cells after norepinephrine treatment.	Norepinephrine	130-144	activating transcription factor 1	Mus musculus	53-57
11311846-11	2001	Norepinephrine reduces the activity of SS neurons and stimulates the secretion of GHRH via alpha(2)-adrenergic receptors.	Norepinephrine	0-14	growth hormone releasing hormone	Bos taurus	82-86
1511346-6	1992	Since norepinephrine stimulates gonadotropin releasing hormone (GnRH) secretion from the median eminence during proestrus and the GnRH neurons do not contain estrogen receptors, it is suggested that the A2 region is, at least in part, responsible for conveying the estrogen signal to the GnRH neurons.	Norepinephrine	6-20	gonadotropin releasing hormone 1	Rattus norvegicus	64-68
12210276-1	2002	Phenylalanine hydroxylase (PAH), which catalyzes the conversion of phenylalanine to tyrosine, shares physical, structural and catalytic properties with tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) that catalyze the rate-limiting steps in the biosynthesis of the neurotransmitters dopamine, noradrenaline, and serotonin.	Norepinephrine	304-317	phenylalanine hydroxylase	Homo sapiens	0-25
12210276-1	2002	Phenylalanine hydroxylase (PAH), which catalyzes the conversion of phenylalanine to tyrosine, shares physical, structural and catalytic properties with tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) that catalyze the rate-limiting steps in the biosynthesis of the neurotransmitters dopamine, noradrenaline, and serotonin.	Norepinephrine	304-317	phenylalanine hydroxylase	Homo sapiens	27-30
1508391-0	1992	Different functional pools of acetylcholinesterase induce changes in rat locus coeruleus noradrenaline metabolism.	Norepinephrine	89-102	acetylcholinesterase	Rattus norvegicus	30-50
1617531-0	1992	Microdialysis of noradrenaline in rostral ventrolateral medulla after intravenous methionine enkephalin administration in anesthetized rats.	Norepinephrine	17-30	proenkephalin	Rattus norvegicus	93-103
12135946-1	2002	BACKGROUND: Whether catechol-O-methyltransferase (COMT), the enzyme that metabolizes extraneuronal norepinephrine, contributes to blood pressure regulation in humans is unknown.	Norepinephrine	99-113	catechol-O-methyltransferase	Homo sapiens	20-48
12135946-1	2002	BACKGROUND: Whether catechol-O-methyltransferase (COMT), the enzyme that metabolizes extraneuronal norepinephrine, contributes to blood pressure regulation in humans is unknown.	Norepinephrine	99-113	catechol-O-methyltransferase	Homo sapiens	50-54
1617531-7	1992	Intravenous infusion of 100 micrograms/kg/min met-enkephalin increased the extracellular concentration of noradrenaline in the C1 area.	Norepinephrine	106-119	proenkephalin	Rattus norvegicus	50-60
21554614-17	1992	Therefore, the data suggest that an endogenous alpha(1) ligand, such as norepinephrine (or epinephrine), is required to maintain a high level of LHRH gene expression in the ovariectomized rat.	Norepinephrine	72-86	gonadotropin releasing hormone 1	Rattus norvegicus	145-149
12055093-6	2002	We conclude that norepinephrine specifically inhibits insulin-stimulated leptin secretion not only via the low-affinity beta3-adrenoceptors but also via the high-affinity beta1/beta2-adrenoceptors.	Norepinephrine	17-31	leptin	Rattus norvegicus	73-79
1567213-6	1992	In a contraction-relaxation-contraction cycle of long duration, 60-min contractions with K+, histamine, or norepinephrine, cyclic phosphorylation of both the light chain and desmin was observed.	Norepinephrine	107-121	desmin	Homo sapiens	174-180
12086933-6	2002	Double-label in situ hybridization demonstrated neuron-specific GK mRNA expression in locus ceruleus norepinephrine and in hypothalamic neuropeptide Y, pro-opiomelanocortin, and gamma-aminobutyric acid neurons, but it did not demonstrate this expression in orexin neurons.	Norepinephrine	101-115	glucokinase	Rattus norvegicus	64-66
12023879-0	2002	Impaired noradrenaline-induced lipolysis in white fat of aP2-Ucp1 transgenic mice is associated with changes in G-protein levels.	Norepinephrine	9-22	transcription factor AP-2, alpha	Mus musculus	57-60
12023879-0	2002	Impaired noradrenaline-induced lipolysis in white fat of aP2-Ucp1 transgenic mice is associated with changes in G-protein levels.	Norepinephrine	9-22	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	61-65
1313447-3	1992	The rate of recovery of pHi was enhanced threefold by pretreatment (37.5 s) with isoproterenol (K1/2 = 21.5 nM) or norepinephrine (in the presence of phentolamine), and blocked by the beta 1-specific antagonist atenolol, indicating an upregulation of cotransport activity by beta 1-adrenergic stimulation.	Norepinephrine	115-129	glucose-6-phosphate isomerase	Rattus norvegicus	24-27
12184062-5	2002	Eprosartan acts not only at vascular AT1 receptors but also at presynaptic AT1 receptors, causing inhibition of sympathetically stimulated noradrenaline release.	Norepinephrine	139-152	angiotensin II receptor type 1	Homo sapiens	75-78
11959640-1	2002	Heart rate (HR) dynamics were investigated in mice deficient in monoamine oxidase A and B, whose phenotype includes elevated tissue levels of norepinephrine, serotonin, dopamine, and phenylethylamine.	Norepinephrine	142-156	monoamine oxidase A	Mus musculus	64-89
12028362-1	2002	Monoamine oxidase-A knockout (MAO-A KO) mice have elevated brain serotonin (5-HT) and noradrenaline (NA) levels, and one would therefore anticipate increased monoamine release and compensatory changes in other aspects of presynaptic monoamine function.	Norepinephrine	86-99	monoamine oxidase A	Mus musculus	0-19
11979726-4	2002	TH heterozygous mice showed a reduction of high K(+)-evoked noradrenaline release in the frontal cortex measured by the microdialysis technique and of cAMP content in the brain.	Norepinephrine	60-73	tyrosine hydroxylase	Mus musculus	0-2
11880481-1	2002	Noradrenaline and serotonin are known to control arginine-vasopressin (AVP) and oxytocin (OT) secretion in the systemic circulation.	Norepinephrine	0-13	arginine vasopressin	Mus musculus	71-74
11880481-3	2002	To test this hypothesis, we used the Tg8 transgenic mice KO for the monoamine oxidase-A gene, which present high levels of noradrenaline and serotonin in the brain.	Norepinephrine	123-136	monoamine oxidase A	Mus musculus	68-87
11880481-9	2002	These results suggest that noradrenaline may activate AVP and OT expression in the PVN and SON.	Norepinephrine	27-40	arginine vasopressin	Mus musculus	54-57
11958827-1	2002	Phenylethanolamine N-methyltransferase (PNMT), the terminal enzyme of the catecholamine biosynthesis pathway, catalyzes the conversion of norepinephrine (NE) to epinephrine (EPI).	Norepinephrine	138-152	phenylethanolamine N-methyltransferase	Homo sapiens	0-38
11958827-1	2002	Phenylethanolamine N-methyltransferase (PNMT), the terminal enzyme of the catecholamine biosynthesis pathway, catalyzes the conversion of norepinephrine (NE) to epinephrine (EPI).	Norepinephrine	138-152	phenylethanolamine N-methyltransferase	Homo sapiens	40-44
11244495-1	2001	Catechol-O-methyltransferase (COMT) is a major component of the metabolic pathways of neurotransmitters such as dopamine, adrenaline, and noradrenaline.	Norepinephrine	138-151	catechol-O-methyltransferase	Homo sapiens	0-28
11244495-1	2001	Catechol-O-methyltransferase (COMT) is a major component of the metabolic pathways of neurotransmitters such as dopamine, adrenaline, and noradrenaline.	Norepinephrine	138-151	catechol-O-methyltransferase	Homo sapiens	30-34
11191837-1	2001	We have tested the role of various protein kinases in noradrenaline-induced, alpha1A-adrenoceptor-mediated constriction of mesenteric and intrarenal rat microvessels.	Norepinephrine	54-67	adrenoceptor alpha 1A	Rattus norvegicus	77-97
1380602-1	1992	Animal experimental evidence suggests that neuropeptide Y (NPY) is coreleased with norepinephrine (NE) from sympathetic nerve endings and is involved in nonadrenergic neurogenic vascular control of skeletal muscle.	Norepinephrine	83-97	neuropeptide Y	Homo sapiens	43-57
11854096-2	2002	In this study, the accumulation of AA-NAT mRNA induced by norepinephrine (NE) and peptides of the secretin superfamily (pituitary adenylate cyclase activating polypeptide (PACAP), vasoactive intestinal peptide (VIP), growth hormone releasing factor (GRF), secretin) was investigated by a new quantitative reverse transcription-PCR (RT-PCR) assay.	Norepinephrine	58-72	adenylate cyclase activating polypeptide 1	Rattus norvegicus	172-177
11819028-3	2002	Infusion of peptide YY (PYY; 1 microg/kg per min) strongly inhibited the stimulation-evoked overflow of noradrenaline and NPY-LI.	Norepinephrine	104-117	peptide YY	Sus scrofa	24-27
11606427-3	2001	Of several genes that were regulated, we focused on macrophage migration inhibitory factor (MIF), which has been associated with the modulation of norepinephrine metabolism.	Norepinephrine	147-161	macrophage migration inhibitory factor	Rattus norvegicus	52-90
11696583-4	2001	In Dio2(-/-) brown adipocytes, the acute norepinephrine-, CL316,243-, or forskolin-induced increases in lipolysis, UCP1 mRNA, and O(2) consumption are all reduced due to impaired cAMP generation.	Norepinephrine	41-55	deiodinase, iodothyronine, type II	Mus musculus	3-7
11696583-4	2001	In Dio2(-/-) brown adipocytes, the acute norepinephrine-, CL316,243-, or forskolin-induced increases in lipolysis, UCP1 mRNA, and O(2) consumption are all reduced due to impaired cAMP generation.	Norepinephrine	41-55	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	115-119
11677361-7	2001	Inhibition of ETA receptors by darusentan reversed aortic alterations produced by infusion of norepinephrine.	Norepinephrine	94-108	endothelin receptor type A	Rattus norvegicus	14-17
11677361-9	2001	CONCLUSIONS: Antagonism of ETA receptors effectively and rapidly reversed norepinephrine-induced aortic structural and compositional changes, suggesting a central role of endothelin in mediating this response.	Norepinephrine	74-88	endothelin receptor type A	Rattus norvegicus	27-30
11764279-8	2001	On the other hand, mice carrying the mutation in the gene encoding tyrosine hydroxylase (the rate-limiting enzyme of catecholamine biosynthesis) display a reduction in norepinephrine biosynthesis.	Norepinephrine	168-182	tyrosine hydroxylase	Mus musculus	67-87
11602687-2	2001	We recently reported that the alpha1A-adrenoceptor predominantly mediates contraction to norepinephrine in human skeletal muscle resistance arteries.	Norepinephrine	89-103	adrenoceptor alpha 1A	Homo sapiens	30-50
11602687-11	2001	These results suggest the predominant involvement of alpha1A-adrenoceptor in the contractile responses to norepinephrine in these arteries.	Norepinephrine	106-120	adrenoceptor alpha 1A	Homo sapiens	53-73
11735324-4	2001	In the human brain model dopamine and noradrenaline were metabolized primarily by MB-COMT.	Norepinephrine	38-51	catechol-O-methyltransferase	Homo sapiens	85-89
11735324-6	2001	It is suggested that MB-COMT clearly predominates the O-methylation of dopamine and noradrenaline also in vivo.	Norepinephrine	84-97	catechol-O-methyltransferase	Homo sapiens	24-28
11566075-8	2001	In conclusion, dopamine D(2)-receptor blockade with domperidone demonstrates that hypoxic exercise in humans activates D(2)-receptors, resulting in a decrease in circulating levels of noradrenaline.	Norepinephrine	184-197	dopamine receptor D2	Homo sapiens	15-37
11680172-1	2001	Using a microphysiometer with synchronized valve switching, we investigated real-time acid extrusion from CHO cells, in which human alpha-1a adrenoceptor (AR) is stably expressed, in response to noradrenaline (NA).	Norepinephrine	195-208	adrenoceptor alpha 1A	Homo sapiens	132-153
1380602-1	1992	Animal experimental evidence suggests that neuropeptide Y (NPY) is coreleased with norepinephrine (NE) from sympathetic nerve endings and is involved in nonadrenergic neurogenic vascular control of skeletal muscle.	Norepinephrine	83-97	neuropeptide Y	Homo sapiens	59-62
1374311-4	1992	Since there was a direct correlation between plasma NPY before exercise and the increment (delta 80%) in noradrenaline during exercise (r = 0.54; P less than 0.01), it is suggested that plasma NPY determined in the basal situation may be a useful marker of sympathetic nerve failure in diabetic patients.	Norepinephrine	105-118	neuropeptide Y	Homo sapiens	52-55
1374311-4	1992	Since there was a direct correlation between plasma NPY before exercise and the increment (delta 80%) in noradrenaline during exercise (r = 0.54; P less than 0.01), it is suggested that plasma NPY determined in the basal situation may be a useful marker of sympathetic nerve failure in diabetic patients.	Norepinephrine	105-118	neuropeptide Y	Homo sapiens	193-196
1346639-4	1992	A qualitatively similar difference in maximum responses to alpha-1 vs. alpha-2 adrenoceptor stimulation in calcium-free saline was demonstrated for norepinephrine in the presence of antagonists selective for the two alpha adrenoceptor subtypes.	Norepinephrine	148-162	adrenoceptor alpha 1D	Homo sapiens	59-66
1320891-1	1992	Neuropeptide Y, one of the most abundant polypeptides within the nervous system, is co-stored with catecholamines, especially norepinephrine (NE), thus suggesting its possible involvement in pathologies characterized by a noradrenergic impairment.	Norepinephrine	126-140	neuropeptide Y	Homo sapiens	0-14
15815433-1	1992	Neuropeptide Y (NPY) a potent vasoconstrictor peptide, is co-stored with the classic neurotransmitter noradrenaline (NA) in certain peripheral sympathetic neurons and has been suggested to be a co-transmitter in vascular control.	Norepinephrine	102-115	neuropeptide Y	Homo sapiens	0-14
15815433-1	1992	Neuropeptide Y (NPY) a potent vasoconstrictor peptide, is co-stored with the classic neurotransmitter noradrenaline (NA) in certain peripheral sympathetic neurons and has been suggested to be a co-transmitter in vascular control.	Norepinephrine	102-115	neuropeptide Y	Homo sapiens	16-19
1860230-3	1991	Homogenates of rat heart, which contain the enzymes phenylethanolamine N-methyltransferase (PNMT) and nonspecific N-methyltransferase (NMT), methylate norepinephrine to form epinephrine.	Norepinephrine	151-165	phenylethanolamine-N-methyltransferase	Rattus norvegicus	52-90
1677640-2	1991	Dopamine beta-hydroxylase (DBH) deficiency is a genetic disorder in which affected patients cannot synthesize norepinephrine, epinephrine, and octopamine in either the central nervous system or the peripheral autonomic neurons.	Norepinephrine	110-124	dopamine beta-hydroxylase	Homo sapiens	0-25
1677640-2	1991	Dopamine beta-hydroxylase (DBH) deficiency is a genetic disorder in which affected patients cannot synthesize norepinephrine, epinephrine, and octopamine in either the central nervous system or the peripheral autonomic neurons.	Norepinephrine	110-124	dopamine beta-hydroxylase	Homo sapiens	27-30
1677923-2	1991	Dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine to norepinephrine, has been implicated in dystonia because of increased serum levels of DBH in some patients, the influence of catecholaminergic drugs on the human phenotypes, and altered norepinephrine levels in several brain regions in dystonia patients and in genetically dystonic rodents.	Norepinephrine	70-84	dopamine beta-hydroxylase	Homo sapiens	0-25
1677923-2	1991	Dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine to norepinephrine, has been implicated in dystonia because of increased serum levels of DBH in some patients, the influence of catecholaminergic drugs on the human phenotypes, and altered norepinephrine levels in several brain regions in dystonia patients and in genetically dystonic rodents.	Norepinephrine	70-84	dopamine beta-hydroxylase	Homo sapiens	27-30
1677923-2	1991	Dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine to norepinephrine, has been implicated in dystonia because of increased serum levels of DBH in some patients, the influence of catecholaminergic drugs on the human phenotypes, and altered norepinephrine levels in several brain regions in dystonia patients and in genetically dystonic rodents.	Norepinephrine	70-84	dopamine beta-hydroxylase	Homo sapiens	155-158
1677923-2	1991	Dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine to norepinephrine, has been implicated in dystonia because of increased serum levels of DBH in some patients, the influence of catecholaminergic drugs on the human phenotypes, and altered norepinephrine levels in several brain regions in dystonia patients and in genetically dystonic rodents.	Norepinephrine	255-269	dopamine beta-hydroxylase	Homo sapiens	0-25
1677923-2	1991	Dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine to norepinephrine, has been implicated in dystonia because of increased serum levels of DBH in some patients, the influence of catecholaminergic drugs on the human phenotypes, and altered norepinephrine levels in several brain regions in dystonia patients and in genetically dystonic rodents.	Norepinephrine	255-269	dopamine beta-hydroxylase	Homo sapiens	27-30
1884244-0	1991	Increased effect of noradrenaline on synaptic responses in rat CA1 hippocampal area after adrenalectomy.	Norepinephrine	20-33	carbonic anhydrase 1	Rattus norvegicus	63-66
11591352-8	2001	The structure of PNMT shows that the inhibitor interacts with the enzyme in a different mode from the (modeled) substrate noradrenaline.	Norepinephrine	122-135	phenylethanolamine N-methyltransferase	Homo sapiens	17-21
11669473-3	2001	VMAT2 differs from the plasma membrane transporters in its capability to recognize serotonin, histamine, norepinephrine and dopamine with almost the same affinity.	Norepinephrine	105-119	solute carrier family 18 member A2	Homo sapiens	0-5
11675940-8	2001	Multiple regression analysis revealed that the reduction in SBP was significantly and positively associated with the reduction in log sigmaIRI and the reduction in log 24h-urinary norepinephrine excretion at the end of Study I.	Norepinephrine	180-194	selenium binding protein 1	Homo sapiens	60-63
11525314-3	2001	The objective of this study was to: (1) pharmacologically elucidate the alpha1-adrenoceptor subtype mediating norepinephrine-induced contraction of human isolated corpus cavernosal tissue and (2) conduct a clinical proof-of-concept study with Ro70-0004 to test the hypothesis that selective alpha1A-adrenoceptor blockade would improve erectile function in patients with MED.	Norepinephrine	110-124	adrenoceptor alpha 1A	Homo sapiens	291-311
11525314-5	2001	Prazosin, cyclazosin, RS-100329 and Ro70-0004/003 antagonized norepinephrine-induced contractile responses with affinity estimates (pK(B) or pA2) of 8.4, 7.3, 9.2 and 8.8, respectively, consistent with the singular involvement of alpha1A-adrenoceptor subtype.	Norepinephrine	62-76	adrenoceptor alpha 1A	Homo sapiens	230-250
11336641-1	2001	6-Nitrodopamine and 6-nitronoradrenaline (6-nitronorepinephrine), putative products of the nitric oxide (NO)-dependent nitration of dopamine and noradrenaline, are reported to be reversible, competitive inhibitors of neuronal nitric oxide synthase (nNOS) with K(i) values of 45 and 52 microM respectively.	Norepinephrine	27-40	nitric oxide synthase 1	Homo sapiens	217-247
11336641-1	2001	6-Nitrodopamine and 6-nitronoradrenaline (6-nitronorepinephrine), putative products of the nitric oxide (NO)-dependent nitration of dopamine and noradrenaline, are reported to be reversible, competitive inhibitors of neuronal nitric oxide synthase (nNOS) with K(i) values of 45 and 52 microM respectively.	Norepinephrine	27-40	nitric oxide synthase 1	Homo sapiens	249-253
11278912-1	2001	tyrosine phosphorylation of phospholipase d2 in response to norepinephrine.	Norepinephrine	60-74	phospholipase D2	Oryctolagus cuniculus	28-44
11331416-8	2001	These results indicate that P2Y6 receptors mediate UTP-evoked noradrenaline release from rat sympathetic neurons via activation of protein kinase C, but not inhibition of K(M) channels.	Norepinephrine	62-75	pyrimidinergic receptor P2Y6	Rattus norvegicus	28-32
11339685-6	2001	In conclusion both AT1- and AT2 receptor activation seems to be important in controlling noradrenaline sensitivity of rat portal vein smooth muscle.	Norepinephrine	89-102	angiotensin II receptor, type 1a	Rattus norvegicus	19-22
11339685-6	2001	In conclusion both AT1- and AT2 receptor activation seems to be important in controlling noradrenaline sensitivity of rat portal vein smooth muscle.	Norepinephrine	89-102	angiotensin II receptor, type 2	Rattus norvegicus	28-31
1657319-6	1991	These data suggest that early exposure of beta-receptors to norepinephrine "programs" the subsequent efficiency of the receptor linkage to ODC during a critical ontogenetic period that occurs prenatally in the cerebral cortex and postnatally in the cerebellum.	Norepinephrine	60-74	ornithine decarboxylase 1	Rattus norvegicus	139-142
1709566-4	1991	The diazepam-treated patients had also smaller CSF concentrations of noradrenaline (NA) and of the dopamine metabolite, 3,4-dihydroxyphenylacetic acid (DOPAC).	Norepinephrine	69-82	colony stimulating factor 2	Homo sapiens	47-50
1648463-0	1991	Effect of angiotensin-converting enzyme inhibition on renal norepinephrine spillover rate and baroreflex responses in conscious rabbits.	Norepinephrine	60-74	angiotensin-converting enzyme	Oryctolagus cuniculus	10-39
1891070-0	1991	Blockade of neuropeptide Y-induced potentiation of noradrenaline-evoked vasoconstriction by D-myo-inositol-1.2.6-trisphosphate (PP56) in rabbit femoral arteries.	Norepinephrine	51-64	neuropeptide Y	Oryctolagus cuniculus	12-26
11264665-0	2001	Overexpression of the myristoylated alanine-rich C kinase substrate decreases uptake and K(+)-evoked release of noradrenaline in the human neuroblastoma SH-SY5Y.	Norepinephrine	112-125	myristoylated alanine rich protein kinase C substrate	Homo sapiens	22-67
11264665-1	2001	The aim of this study was to investigate a possible role of the myristoylated alanine-rich C kinase substrate (MARCKS) in the mechanism of noradrenaline uptake and release in the human neuroblastoma cell line SH-SY5Y.	Norepinephrine	139-152	myristoylated alanine rich protein kinase C substrate	Homo sapiens	64-109
11264665-1	2001	The aim of this study was to investigate a possible role of the myristoylated alanine-rich C kinase substrate (MARCKS) in the mechanism of noradrenaline uptake and release in the human neuroblastoma cell line SH-SY5Y.	Norepinephrine	139-152	myristoylated alanine rich protein kinase C substrate	Homo sapiens	111-117
11264665-5	2001	In contrast, specific uptake and depolarization-evoked (100 mM K(+)) release of noradrenaline from the cell line overexpressing MARCKS was inhibited by approximately 50% compared with mock-transfected SH-SY5Y.	Norepinephrine	80-93	myristoylated alanine rich protein kinase C substrate	Homo sapiens	128-134
11264665-8	2001	Thus, in SH-SY5Y cells, overexpression of MARCKS leads to a decrease in the K(+)-evoked noradrenaline release possibly by increased actin cross-linking preventing the movement of noradrenaline containing large dense-cored vesicles to the plasma membrane in response to depolarization.	Norepinephrine	88-101	myristoylated alanine rich protein kinase C substrate	Homo sapiens	42-48
11264665-8	2001	Thus, in SH-SY5Y cells, overexpression of MARCKS leads to a decrease in the K(+)-evoked noradrenaline release possibly by increased actin cross-linking preventing the movement of noradrenaline containing large dense-cored vesicles to the plasma membrane in response to depolarization.	Norepinephrine	179-192	myristoylated alanine rich protein kinase C substrate	Homo sapiens	42-48
11169504-5	2001	Results from double staining with antibodies to these subunits and to tyrosine hydroxylase, the enzyme that catalyzes the rate-limiting step in the biosynthesis of the sympathetic neurotransmitter norepinephrine, demonstrated that most neurons in the SCG express both the alpha7 and beta4 subunits.	Norepinephrine	197-211	tyrosine hydroxylase	Rattus norvegicus	70-90
1891070-1	1991	Neuropeptide Y (NPY) potentiates noradrenaline (NA)-evoked constriction of circular segments of the rabbit femoral artery.	Norepinephrine	33-46	neuropeptide Y	Oryctolagus cuniculus	0-14
1891070-1	1991	Neuropeptide Y (NPY) potentiates noradrenaline (NA)-evoked constriction of circular segments of the rabbit femoral artery.	Norepinephrine	33-46	neuropeptide Y	Oryctolagus cuniculus	16-19
1850525-2	1991	The response of cardiac and aortic ornithine decarboxylase (ODC) activity to stimulation by norepinephrine was decreased in rats receiving norepinephrine infusion.	Norepinephrine	92-106	ornithine decarboxylase 1	Rattus norvegicus	35-58
1850525-2	1991	The response of cardiac and aortic ornithine decarboxylase (ODC) activity to stimulation by norepinephrine was decreased in rats receiving norepinephrine infusion.	Norepinephrine	92-106	ornithine decarboxylase 1	Rattus norvegicus	60-63
1850525-2	1991	The response of cardiac and aortic ornithine decarboxylase (ODC) activity to stimulation by norepinephrine was decreased in rats receiving norepinephrine infusion.	Norepinephrine	139-153	ornithine decarboxylase 1	Rattus norvegicus	35-58
1850525-2	1991	The response of cardiac and aortic ornithine decarboxylase (ODC) activity to stimulation by norepinephrine was decreased in rats receiving norepinephrine infusion.	Norepinephrine	139-153	ornithine decarboxylase 1	Rattus norvegicus	60-63
1826401-6	1991	In contrast, vasoactive intestinal peptide has convincingly been demonstrated to stimulate thyroid hormone secretion, and neuropeptide Y to potentiate the inhibitory action of noradrenaline on TSH-induced thyroid hormone secretion.	Norepinephrine	176-189	neuropeptide Y	Homo sapiens	122-136
2002450-1	1991	We have found that (R,S)-1-(phenylthio)-aminopropane (4a), a synthetic alternate substrate for the terminal enzyme of norepinephrine biosynthesis, dopamine beta-monooxygenase (DBM), is both an indirect sympathomimetic and a potent antihypertensive agent in spontaneously hypertensive rats.	Norepinephrine	118-132	dopamine beta-hydroxylase	Rattus norvegicus	147-174
11164826-1	2001	3,4-Dihydroxyphenylglycolaldehyde is the monoamine oxidase-A metabolite of two catecholamine neurotransmitters, epinephrine and norepinephrine.	Norepinephrine	128-142	monoamine oxidase A	Rattus norvegicus	41-60
11171057-1	2001	In rat-1 fibroblasts stably expressing rat alpha(1d)-adrenoceptors, noradrenaline and PMA markedly decreased alpha(1d)-adrenoceptor function (noradrenaline-elicited increases in calcium in whole cells and [(35)S]guanosine 5"-[gamma-thio]triphosphate binding in membranes), suggesting homologous and heterologous desensitizations.	Norepinephrine	68-81	adrenoceptor alpha 1D	Rattus norvegicus	43-65
11171057-1	2001	In rat-1 fibroblasts stably expressing rat alpha(1d)-adrenoceptors, noradrenaline and PMA markedly decreased alpha(1d)-adrenoceptor function (noradrenaline-elicited increases in calcium in whole cells and [(35)S]guanosine 5"-[gamma-thio]triphosphate binding in membranes), suggesting homologous and heterologous desensitizations.	Norepinephrine	142-155	adrenoceptor alpha 1D	Rattus norvegicus	43-65
1707425-3	1991	Application of immunocytochemical methods to visualize tachykinins (predominantly substance P magnitude of SP), serotonin (5-HT), and dopamine B-hydroxylase (DBH), the synthesizing enzyme for norepinephrine, permits us to compare the response of SP systems in rat and cat spinal cord and to examine the response of two descending systems, serotoninergic and noradrenergic, to deafferentation.	Norepinephrine	192-206	dopamine beta-hydroxylase	Rattus norvegicus	134-156
11168848-6	2001	The activity of phenylethanolamine N-methyltransferase, the enzyme that converts noradrenaline into adrenaline, is stimulated by glucocorticoids, which causes the conversion of noradrenergic to adrenergic chromaffin cells.	Norepinephrine	81-94	phenylethanolamine N-methyltransferase	Homo sapiens	16-54
1707425-3	1991	Application of immunocytochemical methods to visualize tachykinins (predominantly substance P magnitude of SP), serotonin (5-HT), and dopamine B-hydroxylase (DBH), the synthesizing enzyme for norepinephrine, permits us to compare the response of SP systems in rat and cat spinal cord and to examine the response of two descending systems, serotoninergic and noradrenergic, to deafferentation.	Norepinephrine	192-206	dopamine beta-hydroxylase	Rattus norvegicus	158-161
11228103-3	2001	The functional results showed: (1) prazosin, the selective alpha1-AR antagonist, phentolamine, the alpha1- and alpha2-ARs antagonist, WB 4101 and 5-MU, the selective alpha1A-AR subtype antagonists were potent, competitive antagonists of noradrenaline (NA)-induced contraction (pA2 values of 11.03, 8.06, 9.02 and 8.34, respectively).	Norepinephrine	237-250	adrenoceptor alpha 1A	Homo sapiens	166-176
1671345-10	1991	These results suggest that norepinephrine and neuropeptide Y are released from sympathetic nerves and mediate EFS contraction by occupation of postjunctional alpha-adrenoceptor and neuropeptide Y receptors.	Norepinephrine	27-41	neuropeptide Y	Oryctolagus cuniculus	181-195
11160998-3	2001	The genotype effects on Lep expression in BAT and plasma-LEP were virtually eliminated when the differences in SNS activity between fa/fa and +/fa pups were equalized by artificial rearing of pups under thermoneutral conditions with or without oral norepinephrine (NE) administration.	Norepinephrine	249-263	leptin	Rattus norvegicus	24-27
11123223-0	2001	ANG II potentiates mitogenic effect of norepinephrine in vascular muscle cells: role of FGF-2.	Norepinephrine	39-53	angiogenin	Homo sapiens	0-3
11115406-0	2001	Diacylglycerol kinase theta is translocated and phosphoinositide 3-kinase-dependently activated by noradrenaline but not angiotensin II in intact small arteries.	Norepinephrine	99-112	diacylglycerol kinase, theta	Rattus norvegicus	0-27
1809554-1	1991	The role of noradrenaline precursor on the release of luteinizing hormone-releasing hormone based on the plasma concentration of luteinizing hormone (LH) was studied in rats.	Norepinephrine	12-25	gonadotropin releasing hormone 1	Rattus norvegicus	54-91
1684835-9	1991	The levels of noradrenaline, GABA and glutamate decarboxylase activity were highest in the dentate gyrus and lowest in CA1.	Norepinephrine	14-27	carbonic anhydrase 1	Rattus norvegicus	119-122
1982556-9	1990	Noradrenaline 10 mumol/l produced the same depression of firing, both in the presence of noradrenaline 1 mumol/l and [Met5]enkephalin 0.03 mumol/l.	Norepinephrine	0-13	proenkephalin	Rattus norvegicus	123-133
2226440-1	1990	Catecholamines (adrenaline, noradrenaline and dopamine) are potent inhibitors of phenylalanine 4-monooxygenase (phenylalanine hydroxylase, EC 1.14.16.1).	Norepinephrine	28-41	phenylalanine hydroxylase	Rattus norvegicus	112-137
2226440-4	1990	The high-affinity binding of L-noradrenaline to phenylalanine hydroxylase, as studied by equilibrium microdialysis (anaerobically) and ultrafiltration (aerobically), shows positive cooperativity (h = 1.9); at pH 7.2 and 20 degrees C the rat enzyme binds about 0.5 mol L-noradrenaline/mol subunit with a half-maximal binding (S50) at 0.25 microM L-noradrenaline.	Norepinephrine	29-44	phenylalanine hydroxylase	Rattus norvegicus	48-73
2226440-4	1990	The high-affinity binding of L-noradrenaline to phenylalanine hydroxylase, as studied by equilibrium microdialysis (anaerobically) and ultrafiltration (aerobically), shows positive cooperativity (h = 1.9); at pH 7.2 and 20 degrees C the rat enzyme binds about 0.5 mol L-noradrenaline/mol subunit with a half-maximal binding (S50) at 0.25 microM L-noradrenaline.	Norepinephrine	268-283	phenylalanine hydroxylase	Rattus norvegicus	48-73
2226440-4	1990	The high-affinity binding of L-noradrenaline to phenylalanine hydroxylase, as studied by equilibrium microdialysis (anaerobically) and ultrafiltration (aerobically), shows positive cooperativity (h = 1.9); at pH 7.2 and 20 degrees C the rat enzyme binds about 0.5 mol L-noradrenaline/mol subunit with a half-maximal binding (S50) at 0.25 microM L-noradrenaline.	Norepinephrine	268-283	phenylalanine hydroxylase	Rattus norvegicus	48-73
1976043-2	1990	These neurons have an uptake mechanism for L-DOPA, and contain the enzymes for converting L-DOPA (but not D-DOPA) to dopamine and noradrenaline, i.e. aromatic L-aminoacid decarboxylase and dopamine beta-hydroxylase.	Norepinephrine	130-143	dopamine beta-hydroxylase	Cavia porcellus	189-214
11205744-8	2001	The concentrations of norepinephrine, the major sympathetic neurotransmitter, and growth cone-located synaptophysin, a neurosecretory granule protein, were increased in NGF-treated SH-SY5Y/trkA but not in NT-3-treated SH-SY5Y/trkC cells.	Norepinephrine	22-36	neurotrophic receptor tyrosine kinase 1	Homo sapiens	189-193
11145986-0	2001	N-methyl-D-aspartate receptors mediating hippocampal noradrenaline and striatal dopamine release display differential sensitivity to quinolinic acid, the HIV-1 envelope protein gp120, external pH and protein kinase C inhibition.	Norepinephrine	53-66	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	177-182
11104823-4	2000	We have found that basal catecholamine release was not modified; both CART peptide-(55-102) and TRH, the former with a higher sensitivity, dose-dependently inhibited depolarization-induced dopamine release, and did not affect the stimulated norepinephrine release.	Norepinephrine	241-255	thyrotropin releasing hormone	Rattus norvegicus	96-99
11003990-6	2000	The intravenous injection of norepinephrine in mice decreased the expression of CD44 and CD18 on CD3(-)NK1.1(+) cells (P &lt; 0.01) and increased the number of CD3(-)NK1.1(+) cells in PBMC (P &lt; 0.01).	Norepinephrine	29-43	CD3 antigen, epsilon polypeptide	Mus musculus	97-100
11003990-6	2000	The intravenous injection of norepinephrine in mice decreased the expression of CD44 and CD18 on CD3(-)NK1.1(+) cells (P &lt; 0.01) and increased the number of CD3(-)NK1.1(+) cells in PBMC (P &lt; 0.01).	Norepinephrine	29-43	CD3 antigen, epsilon polypeptide	Mus musculus	160-163
11229360-1	2000	Mice deficient in monoamine oxidase A (MAO A) have increased brain levels of serotonin (5-HT) and norepinephrine and show enhanced aggression.	Norepinephrine	98-112	monoamine oxidase A	Mus musculus	18-37
11229360-1	2000	Mice deficient in monoamine oxidase A (MAO A) have increased brain levels of serotonin (5-HT) and norepinephrine and show enhanced aggression.	Norepinephrine	98-112	monoamine oxidase A	Mus musculus	39-44
11033316-0	2000	Spatial, cellular and temporal basis of vasopressin potentiation of norepinephrine-induced cAMP formation.	Norepinephrine	68-82	thymus, brain and testes associated	Homo sapiens	0-7
2116978-0	1990	Norepinephrine-induced synthesis of the uncoupling protein thermogenin (UCP) and its mitochondrial targeting in brown adipocytes differentiated in culture.	Norepinephrine	0-14	uncoupling protein 1	Homo sapiens	59-70
10967202-9	2000	Rat alpha-CGRP (10 nM) attenuated contractile responses of the rat prostate to exogenously added noradrenaline (1-100 microM).	Norepinephrine	97-110	calcitonin-related polypeptide alpha	Rattus norvegicus	10-14
2116978-0	1990	Norepinephrine-induced synthesis of the uncoupling protein thermogenin (UCP) and its mitochondrial targeting in brown adipocytes differentiated in culture.	Norepinephrine	0-14	uncoupling protein 1	Homo sapiens	72-75
2116978-3	1990	The synthesis of UCP was stimulated by norepinephrine at physiological concentrations and was observable already after 2 h. It was evident from immunoelectron microscopy that the newly synthesised protein was targeted to the mitochondrial inner membrane, demonstrating the functional competence of these cultured cells.	Norepinephrine	39-53	uncoupling protein 1	Homo sapiens	17-20
2386305-3	1990	Although uptake1 is the most important process for the removal of norepinephrine from the synaptic cleft, the net accumulation of norepinephrine within the neuron also depends on other factors including its vesicular uptake and storage within the granules, its metabolism by monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT), and the efflux of its more lipophilic metabolites.	Norepinephrine	130-144	catechol-O-methyltransferase	Rattus norvegicus	303-331
2386305-3	1990	Although uptake1 is the most important process for the removal of norepinephrine from the synaptic cleft, the net accumulation of norepinephrine within the neuron also depends on other factors including its vesicular uptake and storage within the granules, its metabolism by monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT), and the efflux of its more lipophilic metabolites.	Norepinephrine	130-144	catechol-O-methyltransferase	Rattus norvegicus	333-337
2156732-3	1990	The response to norepinephrine was fully inhibited by the alpha 1-adrenergic antagonist prazosin, but was unaffected by the beta-adrenergic antagonist propranolol, showing that norepinephrine stimulated the 36Cl- efflux pathway via the alpha 1-adrenoceptor.	Norepinephrine	16-30	adrenoceptor alpha 1D	Homo sapiens	58-65
2156732-3	1990	The response to norepinephrine was fully inhibited by the alpha 1-adrenergic antagonist prazosin, but was unaffected by the beta-adrenergic antagonist propranolol, showing that norepinephrine stimulated the 36Cl- efflux pathway via the alpha 1-adrenoceptor.	Norepinephrine	16-30	adrenoceptor alpha 1D	Homo sapiens	236-243
2156732-3	1990	The response to norepinephrine was fully inhibited by the alpha 1-adrenergic antagonist prazosin, but was unaffected by the beta-adrenergic antagonist propranolol, showing that norepinephrine stimulated the 36Cl- efflux pathway via the alpha 1-adrenoceptor.	Norepinephrine	177-191	adrenoceptor alpha 1D	Homo sapiens	58-65
2156732-3	1990	The response to norepinephrine was fully inhibited by the alpha 1-adrenergic antagonist prazosin, but was unaffected by the beta-adrenergic antagonist propranolol, showing that norepinephrine stimulated the 36Cl- efflux pathway via the alpha 1-adrenoceptor.	Norepinephrine	177-191	adrenoceptor alpha 1D	Homo sapiens	236-243
2346958-12	1990	Local release of neuropeptide Y during cardiac ischaemia may be involved in the regulation of coronary vascular tone as well as in the release of noradrenaline and acetylcholine.	Norepinephrine	146-159	neuropeptide Y	Homo sapiens	17-31
10930187-4	2000	ETB receptor responsiveness was tested by sarafotoxin S6c (1-100 nmol/l) and IRL-1620 (0.1-10 nmol/l) concentration-response curves, obtained in the noradrenaline-precontracted MVB.	Norepinephrine	149-162	endothelin receptor type B	Rattus norvegicus	0-3
10898900-2	2000	The enzyme catechol-O-methyltransferase (COMT) plays a key role in the degradation of catecholamines such as dopamine, L-DOPA, adrenaline, and noradrenaline and therefore could be considered as a candidate locus for ADHD susceptibility.	Norepinephrine	143-156	catechol-O-methyltransferase	Homo sapiens	11-39
10898900-2	2000	The enzyme catechol-O-methyltransferase (COMT) plays a key role in the degradation of catecholamines such as dopamine, L-DOPA, adrenaline, and noradrenaline and therefore could be considered as a candidate locus for ADHD susceptibility.	Norepinephrine	143-156	catechol-O-methyltransferase	Homo sapiens	41-45
10888263-5	2000	The calmodulin inhibitor W7 caused a 50 +/- 10% decrease (n = 8; P&lt;0.05) of norepinephrine stimulated protein synthesis, whereas the endothelin-1 response was unaffected.	Norepinephrine	79-93	calmodulin 1	Rattus norvegicus	4-14
10843184-5	2000	Only nocturnal urinary norepinephrine excretion could explain a significant fraction of the variability in both UCP2 and UCP3 expression in muscle, but not adipose tissue.	Norepinephrine	23-37	uncoupling protein 2	Homo sapiens	112-116
10767058-7	2000	These results indicate that synapsin I plays a role in regulating noradrenaline release.	Norepinephrine	66-79	synapsin I	Mus musculus	28-38
10737614-0	2000	Norepinephrine-stimulated increase in Na+, K+-ATPase activity in the rat brain is mediated through alpha1A-adrenoceptor possibly by dephosphorylation of the enzyme.	Norepinephrine	0-14	adrenoceptor alpha 1A	Rattus norvegicus	99-119
10737614-6	2000	Based on these results and our previous findings, it is proposed that norepinephrine acted on alpha1A-adrenoceptor and increased intracellular calcium, which in the presence of calmodulin activated a calmodulin-dependent phosphatase, calcineurin.	Norepinephrine	70-84	adrenoceptor alpha 1A	Rattus norvegicus	94-114
10737614-6	2000	Based on these results and our previous findings, it is proposed that norepinephrine acted on alpha1A-adrenoceptor and increased intracellular calcium, which in the presence of calmodulin activated a calmodulin-dependent phosphatase, calcineurin.	Norepinephrine	70-84	calmodulin 1	Rattus norvegicus	177-187
10737614-6	2000	Based on these results and our previous findings, it is proposed that norepinephrine acted on alpha1A-adrenoceptor and increased intracellular calcium, which in the presence of calmodulin activated a calmodulin-dependent phosphatase, calcineurin.	Norepinephrine	70-84	calmodulin 1	Rattus norvegicus	200-210
2108240-1	1990	The involvement of intrasynaptosomal-free Ca++ concentration [( Ca++]i) in Na(+)-dependent release of endogenous dopamine and noradrenaline from rat brain synaptosomes was studied.	Norepinephrine	126-139	carbonic anhydrase 1	Rattus norvegicus	64-70
2108240-10	1990	The EGTA-stimulated release of dopamine and noradrenaline was blocked by La which also significantly blocked the decrease in [Ca++]i observed after the addition of EGTA.	Norepinephrine	44-57	carbonic anhydrase 1	Rattus norvegicus	126-132
2154750-1	1990	The adrenergic receptors (ARs) (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine.	Norepinephrine	261-275	adrenoceptor alpha 1D	Homo sapiens	41-77
10890507-3	2000	The majority of cells were noradrenergic neurons in which dopamine-beta-hydroxylase, the enzyme that catalyzes norepinephrine synthesis, and neuropeptide Y coexisted.	Norepinephrine	111-125	dopamine beta-hydroxylase	Equus caballus	58-83
10961737-12	1999	These results suggest that bradykinin mediates facilitation of noradrenaline release via the local release of angiotensin onto an atypical AT1 receptor.	Norepinephrine	63-76	angiotensin II receptor, type 1a	Rattus norvegicus	139-142
2077856-2	1990	NPY is a putative neurotransmitter mainly co-localized with noradrenaline in sympathetic fibers which innervate the cerebral vasculature.	Norepinephrine	60-73	neuropeptide Y	Homo sapiens	0-3
10698124-7	1999	ADM concentration-dependently raised basal catecholamine (epinephrine and norepinephrine) release by rat adrenomedullary fragments, and again the response was blocked by both ADM(22-52) and CGRP(8-37).	Norepinephrine	74-88	calcitonin-related polypeptide alpha	Rattus norvegicus	190-194
10564704-0	1999	Salivary secretion of highly concentrated chromogranin a in response to noradrenaline and acetylcholine in isolated and perfused rat submandibular glands.	Norepinephrine	72-85	chromogranin A	Rattus norvegicus	42-56
2350482-1	1990	Norepinephrine is known to play a role in regulating the circadian rhythms of serotonin N-acetyltransferase activity and melatonin formation in the chick pineal gland.	Norepinephrine	0-14	aralkylamine N-acetyltransferase	Gallus gallus	78-107
10499537-11	1999	These studies establish that norepinephrine is required for leptin to regulate its own expression in WAT and UCP1 expression in BAT and indicate that these effects are likely mediated through the centrally expressed long form of the leptin receptor.	Norepinephrine	29-43	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	109-113
10480609-6	1999	A single injection of leptin (0.25-1.0 mg i.v./rat or 0.5-2.0 pg i.c.v./rat) increased plasma norepinephrine (NE) and epinephrine (EPI) concentrations in a dose-dependent manner.	Norepinephrine	94-108	leptin	Rattus norvegicus	22-28
2293574-4	1990	In contrast, adrenal homogenates, which N-methylate norepinephrine to form epinephrine using the enzyme phenylethanolamine-N-methyltransferase (PNMT), methylated dopamine only about 1% as well as norepinephrine.	Norepinephrine	52-66	phenylethanolamine-N-methyltransferase	Rattus norvegicus	104-142
10448071-3	1999	We have investigated the ability of norepinephrine (NE), which rises rapidly in plasma after liver resection, to trigger elevated production of HGF in MRC-5 human embryonic lung fibroblasts.	Norepinephrine	36-50	hepatocyte growth factor	Homo sapiens	144-147
2293574-4	1990	In contrast, adrenal homogenates, which N-methylate norepinephrine to form epinephrine using the enzyme phenylethanolamine-N-methyltransferase (PNMT), methylated dopamine only about 1% as well as norepinephrine.	Norepinephrine	52-66	phenylethanolamine-N-methyltransferase	Rattus norvegicus	144-148
2151774-6	1990	NPY is coreleased with norepinephrine by perivascular nerve endings.	Norepinephrine	23-37	neuropeptide Y	Homo sapiens	0-3
2104880-2	1990	Because (a) NPY has been shown to be colocalized with noradrenaline in peripheral as well as central catecholaminergic neurons, and (b) alpha 2-adrenergic receptors of adipocytes play a major role in the regulation of lipolysis, we investigated the effect of NPY and PYY on isolated fat cells.	Norepinephrine	54-67	neuropeptide Y	Homo sapiens	12-15
10428055-4	1999	Elevation of cellular cGMP content by treatment with norepinephrine, zaprinast (a cGMP phosphodiesterase inhibitor), or nitroprusside was effective in activating MAPK.	Norepinephrine	53-67	mitogen activated protein kinase 3	Rattus norvegicus	162-166
2106713-3	1990	The LHRH released by the median eminence (ME) of castrated rats in the presence of PGE2 (10(-6) M), LTC4 (10(-8) M), norepinephrine (NE) (10(-5) M) or dopamine (DA) (10(-5) M and 10(-4) M) was significantly lower than the LHRH released by intact animals in the presence of these factors.	Norepinephrine	117-131	gonadotropin releasing hormone 1	Rattus norvegicus	4-8
2404349-2	1990	Values of vanillylmandelic acid, homovanillic acid, and noradrenaline excreted in urine were significantly higher in patients with 1 to 10 copies of N-myc (L-group) than in those patients who had more than 10 copies (H-group), whereas values of dopamine in urine were not significantly different between the groups.	Norepinephrine	56-69	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	149-154
24515890-3	2015	Considering norepinephrine-mediated Ca(2+) influx and subsequent protein kinase A (PKA) activation is responsible for downstream cAMP-response element-binding protein (CREB) phosphorylation and melatonin biosynthesis, the present study determined whether Ca(2+) expression, together with the molecular machinery participated in melatonin production would significantly alter after ESD.	Norepinephrine	12-26	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	65-81
10432475-4	1999	The selective 5-HT1A receptor antagonist, WAY100,635, slightly attenuated the (-)-pindolol-induced increase in DA and NAD levels, while the selective 5-HT1B antagonist, SB224,289, was ineffective.	Norepinephrine	118-121	5-hydroxytryptamine receptor 1A	Rattus norvegicus	14-20
10371700-5	1999	In addition, plasma norepinephrine content was enhanced in accordance with cardiac hypertrophy, cardiac beta ARK1 expression, LV dP/d t max, and LVEDP.	Norepinephrine	20-34	G protein-coupled receptor kinase 2	Rattus norvegicus	104-113
24515890-3	2015	Considering norepinephrine-mediated Ca(2+) influx and subsequent protein kinase A (PKA) activation is responsible for downstream cAMP-response element-binding protein (CREB) phosphorylation and melatonin biosynthesis, the present study determined whether Ca(2+) expression, together with the molecular machinery participated in melatonin production would significantly alter after ESD.	Norepinephrine	12-26	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	83-86
10423683-10	1999	In the adult, AChE activity was weakly seen in the clusters of several chromaffin cells showing noradrenaline fluorescence in the adrenal medulla.	Norepinephrine	96-109	acetylcholinesterase	Mus musculus	14-18
10423684-5	1999	AChE activity was strong in a few large ganglion cells and weak in chromaffin cells showing noradrenaline fluorescence, and was found in numerous nerve bundles and fibers of the medulla.	Norepinephrine	92-105	acetylcholinesterase	Mus musculus	0-4
24515890-3	2015	Considering norepinephrine-mediated Ca(2+) influx and subsequent protein kinase A (PKA) activation is responsible for downstream cAMP-response element-binding protein (CREB) phosphorylation and melatonin biosynthesis, the present study determined whether Ca(2+) expression, together with the molecular machinery participated in melatonin production would significantly alter after ESD.	Norepinephrine	12-26	cAMP responsive element binding protein 1	Rattus norvegicus	129-166
24515890-3	2015	Considering norepinephrine-mediated Ca(2+) influx and subsequent protein kinase A (PKA) activation is responsible for downstream cAMP-response element-binding protein (CREB) phosphorylation and melatonin biosynthesis, the present study determined whether Ca(2+) expression, together with the molecular machinery participated in melatonin production would significantly alter after ESD.	Norepinephrine	12-26	cAMP responsive element binding protein 1	Rattus norvegicus	168-172
22844708-3	2012	Additionally, the enzyme dopamine-beta-hydroxylase catalysing the conversion of dopamine to noradrenaline (DbetaH) was immunolocalized in these vessels.	Norepinephrine	92-105	dopamine beta-hydroxylase	Homo sapiens	25-50
10320014-0	1999	Noradrenaline-degrading activity of monoamine oxidase is localized in noradrenergic neurons of the locus coeruleus of the rat.	Norepinephrine	0-13	monoamine oxidase A	Rattus norvegicus	36-53
10320014-1	1999	We found intense monoamine oxidase (MAO) activity in rat locus coeruleus (LC) neurons by means of a histochemical method using noradrenaline as a substrate.	Norepinephrine	127-140	monoamine oxidase A	Rattus norvegicus	17-34
10320014-1	1999	We found intense monoamine oxidase (MAO) activity in rat locus coeruleus (LC) neurons by means of a histochemical method using noradrenaline as a substrate.	Norepinephrine	127-140	monoamine oxidase A	Rattus norvegicus	36-39
10320014-3	1999	The results indicate that noradrenaline produced in LC neurons might be degraded by MAO type A activity.	Norepinephrine	26-39	monoamine oxidase A	Rattus norvegicus	84-87
34970413-5	2021	The norepinephrine (NE) triggered beta 2-AR to activate the FOXO1/NF-kappaB pathway, which induced endometrial inflammation.	Norepinephrine	4-18	adenosine A2a receptor	Homo sapiens	34-43
34938289-10	2021	Among critically ill patients, MCP-1 predicted the duration of mechanical ventilation, highest norepinephrine dose administered, and length of intensive care stay.	Norepinephrine	95-109	C-C motif chemokine ligand 2	Homo sapiens	31-36
34789005-7	2021	In vitro, human embryonic kidney cells were used to investigate the fractionation of SGLT2 after norepinephrine treatment.	Norepinephrine	97-111	solute carrier family 5 member 2	Homo sapiens	85-90
34503991-10	2021	Significance Statement Endogenous catecholamines are metabolized by monoamine oxidase (MAO)-A and -B, yielding the catecholaldehydes 3,4-dihydroxyphenylacetaldehyde (DOPAL) from dopamine (DA) and 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL) from norepinephrine (NE) and epinephrine (EPI).	Norepinephrine	245-259	monoamine oxidase A	Homo sapiens	68-100
34782792-5	2021	Slit3 binds to the ROBO1 receptor on sympathetic neurons to stimulate Ca2+/calmodulin-dependent protein kinase II signalling and norepinephrine release, which enhances adipocyte thermogenesis.	Norepinephrine	129-143	slit guidance ligand 3	Mus musculus	0-5
10192100-5	1999	The Mgi of the lymphocytes treated in vitro with noradrenaline (NA) significantly decreased in comparison with the control (M +/- SD, basal: 244 +/- 26 mumol/l; NA: 198 +/- 25 mumol/l; p = 0.0001), whereas it did not change after incubation with NA and propranolol (P) (M +/- SD, basal: 238 +/- 32 mumol/l; NA + P: 239 +/- 30 mumol/l; NS).	Norepinephrine	49-62	MSD	Homo sapiens	124-132
10192100-5	1999	The Mgi of the lymphocytes treated in vitro with noradrenaline (NA) significantly decreased in comparison with the control (M +/- SD, basal: 244 +/- 26 mumol/l; NA: 198 +/- 25 mumol/l; p = 0.0001), whereas it did not change after incubation with NA and propranolol (P) (M +/- SD, basal: 238 +/- 32 mumol/l; NA + P: 239 +/- 30 mumol/l; NS).	Norepinephrine	49-62	MSD	Homo sapiens	270-278
10100093-4	1999	ETB receptor responsiveness was tested by sarafotoxin S6c concentration-response curves, obtained in the noradrenaline-precontracted mesenteric vascular bed, and repeated after treatment with BQ-788 and after endothelial denudation.	Norepinephrine	105-118	endothelin receptor type B	Rattus norvegicus	0-3
9831823-2	1999	Adrenergic agonists and antagonists showed activation and inhibition constants consistent with the presence of beta2-receptors: Ka of isoproterenol &lt; epinephrine &lt; norepinephrine &lt; phenylephrine; Ki of timolol &lt; betaxolol &lt; celiprolol &lt; atenolol.	Norepinephrine	170-184	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	111-116
9928772-7	1999	In preparations from animals treated 14 days previously with intrathecal NGF, 69% of neurons responded with depolarizing responses whilst 18% of neurons responded to bath applied noradrenaline in tissue prepared from naive animals.	Norepinephrine	179-192	nerve growth factor	Rattus norvegicus	73-76
10389141-2	1999	MAO A preferentially oxidizes serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE), whereas MAO B preferentially oxidizes phenylethylamine (PEA).	Norepinephrine	72-86	monoamine oxidase A	Mus musculus	0-5
34425806-0	2021	Norepinephrine modulates IL-1beta-induced catabolic response of human chondrocytes.	Norepinephrine	0-14	interleukin 1 alpha	Homo sapiens	25-33
34099360-8	2021	Via its inhibitory and excitatory effects on neurons and microglia, noradrenaline sometimes prevents and sometimes accelerates the production and accumulation of amyloid-beta and tau in various brain regions.	Norepinephrine	68-81	microtubule associated protein tau	Homo sapiens	179-182
34116546-8	2021	Our results showed the likelihood that dopamine, ephedrine, and norepinephrine had the lowest probability of decreasing ScO2.	Norepinephrine	64-78	synthesis of cytochrome C oxidase 2	Homo sapiens	120-124
34116546-9	2021	The suggested rank order to maintain ScO2, from higher to lower, was dopamine <ephedrine <norepinephrine <phenylephrine.	Norepinephrine	90-104	synthesis of cytochrome C oxidase 2	Homo sapiens	37-41
34116546-11	2021	Compared with dopamine, the mean difference (95% credible interval) of ScO2 reduction was: ephedrine -3.19 (-15.74, 8.82), norepinephrine -4.44 (-18.23, 9.63) and phenylephrine -6.93 (-18.31, 4.47).	Norepinephrine	123-137	synthesis of cytochrome C oxidase 2	Homo sapiens	71-75
34596459-2	2021	Brain glycogen phosphorylase (GP)-brain (GPbb; AMP-sensitive) and -muscle (GPmm; norepinephrine-sensitive) type isoforms facilitate stimulus-specific control of glycogen disassembly.	Norepinephrine	81-95	glycogen phosphorylase B	Rattus norvegicus	0-28
35501783-9	2022	We additionally demonstrate that the calcium concentration in the brain of mice increases upon IRISIN stimulation, followed by an increase in the content of excitatory amino acids and norepinephrine, while Trpc3-/- mice exhibit the reverse effect.	Norepinephrine	184-198	fibronectin type III domain containing 5	Homo sapiens	95-101
35079095-3	2022	Here we show that norepinephrine (NE) secretion from ICA cells is increased through activation of Toll-like receptor 4 (TLR4) to aggravate myocardial TNF-alpha production and dysfunction by lipopolysaccharide (LPS).	Norepinephrine	18-32	toll like receptor 4	Homo sapiens	98-118
35079095-3	2022	Here we show that norepinephrine (NE) secretion from ICA cells is increased through activation of Toll-like receptor 4 (TLR4) to aggravate myocardial TNF-alpha production and dysfunction by lipopolysaccharide (LPS).	Norepinephrine	18-32	toll like receptor 4	Homo sapiens	120-124
2603996-5	1989	Norepinephrine (10(-9)-3 x 10(-4) M) caused dose-dependent contraction that was blocked by phentolamine and by the inhibitors of cyclooxygenase but was not modified by endothelium removal.	Norepinephrine	0-14	prostaglandin-endoperoxide synthase 1	Canis lupus familiaris	129-143
2573552-4	1989	While adrenaline and the activity of the enzyme phenylethanolamine N-methyltransferase (PNMT), which converts noradrenaline to adrenaline, were present at Embryonic Day 17.3 (E17.3), they were not detectable in E16.3 adrenals.	Norepinephrine	110-123	phenylethanolamine-N-methyltransferase	Rattus norvegicus	48-86
2573552-4	1989	While adrenaline and the activity of the enzyme phenylethanolamine N-methyltransferase (PNMT), which converts noradrenaline to adrenaline, were present at Embryonic Day 17.3 (E17.3), they were not detectable in E16.3 adrenals.	Norepinephrine	110-123	phenylethanolamine-N-methyltransferase	Rattus norvegicus	88-92
2557227-9	1989	Protein synthesis inhibitors cycloheximide and anisomycin also increased markedly the concentration of c-fos mRNA, and in the presence of anisomycin c-fos mRNA was superinduced by the alpha-adrenergic agonist norepinephrine.	Norepinephrine	209-223	FBJ osteosarcoma oncogene	Mus musculus	103-108
2557227-9	1989	Protein synthesis inhibitors cycloheximide and anisomycin also increased markedly the concentration of c-fos mRNA, and in the presence of anisomycin c-fos mRNA was superinduced by the alpha-adrenergic agonist norepinephrine.	Norepinephrine	209-223	FBJ osteosarcoma oncogene	Mus musculus	149-154
2607250-0	1989	Direct pituitary inhibition of prolactin secretion by dopamine and noradrenaline in sheep.	Norepinephrine	67-80	prolactin	Ovis aries	31-40
9884072-15	1998	We conclude that PAR2APs (but not PAR1APs) via a receptor distinct from PAR2, can cause a contractile response in endothelium-intact HUV tissue via the release of a diffusable EDCF, that is different from previously recognized smooth muscle agonists (e.g. prostanoid metabolites, endothelin, noradrenaline, angiotensin-II, acetylcholine).	Norepinephrine	292-305	F2R like trypsin receptor 1	Homo sapiens	17-21
9722148-0	1998	The human immunodeficiency virus-1 envelope protein gp120 binds through its V3 sequence to the glycine site of N-methyl-D-aspartate receptors mediating noradrenaline release in the hippocampus.	Norepinephrine	152-165	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	52-57
9722148-1	1998	Recent results show that the HIV-1 protein gp120 can enhance N-methyl-D-aspartate receptor-mediated release of noradrenaline from CNS nerve endings.	Norepinephrine	111-124	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	43-48
2607250-1	1989	The effects of dopamine, noradrenaline and 3,4-dihydroxyphenylacetic acid (DOPAC) on the release of prolactin were examined in ovariectomized ewes.	Norepinephrine	25-38	prolactin	Ovis aries	100-109
2607250-11	1989	We conclude that the secretion of prolactin from the pituitary gland is under dual inhibitory regulation by both dopamine and noradrenaline in the sheep.	Norepinephrine	126-139	prolactin	Ovis aries	34-43
9808370-4	1998	Injections of an anti-NGF antiserum during postnatal days (PN) PN 8-14, PN 13-19 or during PN 17-23 counteracted the capsaicin effect and reduced noradrenaline towards control levels.	Norepinephrine	146-159	nerve growth factor	Rattus norvegicus	22-25
9648894-0	1998	Norepinephrine increases cyclic GMP levels in cerebellar cells from neuronal nitric oxide synthase knockout mice.	Norepinephrine	0-14	5'-nucleotidase, cytosolic II	Mus musculus	32-35
9648894-0	1998	Norepinephrine increases cyclic GMP levels in cerebellar cells from neuronal nitric oxide synthase knockout mice.	Norepinephrine	0-14	nitric oxide synthase 1, neuronal	Mus musculus	77-98
9648894-3	1998	In this study, we report that in primary cell cultures from the cerebellum of neuronal NOS knockout mice, norepinephrine stimulates an increase in cyclic GMP content.	Norepinephrine	106-120	5'-nucleotidase, cytosolic II	Mus musculus	154-157
9648894-5	1998	These results suggest a novel pathway by which norepinephrine enhances cyclic GMP levels in the nervous system.	Norepinephrine	47-61	5'-nucleotidase, cytosolic II	Mus musculus	78-81
9596526-1	1998	Alpha-adrenergic receptor, subtype 2A (alpha2A-AR), activation is one of the primary modes of action for norepinephrine (NE) in the rat hippocampal formation.	Norepinephrine	105-119	adrenoceptor alpha 2A	Rattus norvegicus	39-49
9539213-8	1998	The selective serotonin-1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT), reduced serotonin levels (-65%) and increased those of dopamine and noradrenaline by +100%), and +175%, respectively.	Norepinephrine	166-179	5-hydroxytryptamine receptor 1A	Rattus norvegicus	14-35
9605572-5	1998	Adrenomedullin and alpha-CGRP caused a concentration-dependent relaxation in the rat aorta contracted with noradrenaline.	Norepinephrine	107-120	calcitonin-related polypeptide alpha	Rattus norvegicus	25-29
9556076-4	1998	Neuronal AT1 receptors are involved in norepinephrine (NE) neuromodulation.	Norepinephrine	39-53	angiotensin II receptor type 1	Homo sapiens	9-12
2576431-1	1989	The effects of the beta 1-adrenoceptor blocking drug atenolol and the beta 2-adrenoceptor blocking drug ICI 118551 (ICI, Melbourne, Australia) on noradrenaline release and blood pressure were investigated using the pithed rat, which was subjected to continuous electrical stimulation of the spinal sympathetic outflow (pulses at 3 Hz).	Norepinephrine	146-159	adrenoceptor beta 2	Rattus norvegicus	70-89
9461536-0	1998	Effects of noradrenaline on the cell-surface glucose transporters in cultured brown adipocytes: novel mechanism for selective activation of GLUT1 glucose transporters.	Norepinephrine	11-24	solute carrier family 2 member 1	Rattus norvegicus	140-145
9461536-7	1998	However, noradrenaline induced an increase in photoaffinity labelling of cell-surface GLUT1 without an apparent increase in the immunoreactive GLUT1 protein in the plasma membrane.	Norepinephrine	9-22	solute carrier family 2 member 1	Rattus norvegicus	86-91
9461536-10	1998	The increased photoaffinity labelling of GLUT1 and increased glucose transport caused by noradrenaline were inhibited by a cAMP antagonist, cAMP-S Rp-isomer.	Norepinephrine	89-102	solute carrier family 2 member 1	Rattus norvegicus	41-46
9461536-11	1998	These results demonstrate that noradrenaline stimulates glucose transport in brown adipocytes by enhancing the functional activity of GLUT1 through a cAMP-dependent mechanism.	Norepinephrine	31-44	solute carrier family 2 member 1	Rattus norvegicus	134-139
2698933-3	1989	Rats treated with 0.3 mg nitrofurantoin showed a 50% decrease in glutathione reductase activity with a twofold increase in the ratio of glutathione disulphide to reduced glutathione in the hypothalamus and brainstem, and a 1.5-fold increase in plasma noradrenaline and plasma renin activity compared with controls.	Norepinephrine	251-264	glutathione-disulfide reductase	Rattus norvegicus	65-86
2553251-2	1989	Epinephrine (Epi) and norepinephrine (NE) activated AH130 adenylate cyclase about half as much as isoproterenol (IPN) but equaled IPN after treatment with the alpha-antagonist phentolamine or islet-activating protein (IAP).	Norepinephrine	22-36	magnesium transporter 1	Rattus norvegicus	192-216
2553251-2	1989	Epinephrine (Epi) and norepinephrine (NE) activated AH130 adenylate cyclase about half as much as isoproterenol (IPN) but equaled IPN after treatment with the alpha-antagonist phentolamine or islet-activating protein (IAP).	Norepinephrine	22-36	magnesium transporter 1	Rattus norvegicus	218-221
2781292-5	1989	In addition, glucocorticoids attenuated the norepinephrine-induced blockade of action potential accommodation in CA1 neurons.	Norepinephrine	44-58	carbonic anhydrase 1	Rattus norvegicus	113-116
9426309-9	1998	[3H]-noradrenaline release was reduced by nifedipine, suggesting an important role for L-Ca2+ channels in neurotransmitter release.	Norepinephrine	5-18	clathrin, light chain A	Rattus norvegicus	87-92
2570461-3	1989	Exposure of eukaryotic cells transfected with this gene to adrenaline or noradrenaline promotes the accumulation of adenosine 3",5"-monophosphate; only 2 of 11 classical beta-AR blockers efficiently inhibited this effect, whereas two others behaved as beta 3-AR agonists.	Norepinephrine	73-86	adrenoceptor beta 3	Homo sapiens	252-261
2568991-4	1989	Treatment of pinealocytes with the physiological regulator of pineal function, norepinephrine, resulted in a concentration-dependent increase in pHi.	Norepinephrine	79-93	glucose-6-phosphate isomerase	Rattus norvegicus	145-148
2568991-9	1989	These findings provide evidence that 1) alpha 1-adrenergic receptor activation increases pinealocyte pHi through Ca2+----protein kinase C-dependent activation of the Na+/H+ antiporter; and 2) norepinephrine stimulation of cGMP accumulation is pHi-dependent.	Norepinephrine	192-206	glucose-6-phosphate isomerase	Rattus norvegicus	243-246
2764101-6	1989	NPY (10(-10) to 10(-6) M) exerted a direct vasoconstrictory effect on small arteries dissected from the cervix and an additive effect of NPY and norepinephrine responses was observed.	Norepinephrine	145-159	neuropeptide Y	Homo sapiens	0-3
2668503-0	1989	Effects of neuropeptide Y on the response of isolated blood vessels to norepinephrine and sympathetic field stimulation.	Norepinephrine	71-85	neuropeptide Y	Oryctolagus cuniculus	11-25
9539874-0	1998	Effects of norepinephrine on expression of IGF-1/IGF-1R and SERCA2 in rat heart.	Norepinephrine	11-25	insulin-like growth factor 1 receptor	Rattus norvegicus	49-55
2668503-8	1989	NPY also produced an endothelium-dependent potentiation of the constrictor response to exogenous norepinephrine in superfused segments of both ear artery and saphenous vein.	Norepinephrine	97-111	neuropeptide Y	Oryctolagus cuniculus	0-3
2568732-1	1989	The alpha-adrenoceptor-mediated contractile effects of noradrenaline (alpha 1 + alpha 2), phenylephrine (alpha 1) and clonidine (alpha 2) on human saphenous veins were investigated in vivo and in vitro.	Norepinephrine	55-68	adrenoceptor alpha 1D	Homo sapiens	70-77
2570849-0	1989	Inhibition of Na+,K+-ATPase activity by phospholipase A2 and several lysophospholipids: possible role of phospholipase A2 in noradrenaline release from cerebral cortical synaptosomes.	Norepinephrine	125-138	phospholipase A2 group IB	Rattus norvegicus	105-121
2472177-0	1989	CSF norepinephrine in schizophrenia is elevated prior to relapse after haloperidol withdrawal.	Norepinephrine	4-18	colony stimulating factor 2	Homo sapiens	0-3
2472177-5	1989	CSF norepinephrine (NE), 3-methoxy-4-hydroxyphenylglycol (MHPG), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5 HIAA) concentrations were measured with high-pressure liquid chromatography (HPLC).	Norepinephrine	4-18	colony stimulating factor 2	Homo sapiens	0-3
2566715-7	1989	Noradrenaline excites supraoptic neurons and leads to phasic firing through an alpha-1 mechanism and decreased K+-conductance.	Norepinephrine	0-13	adrenoceptor alpha 1D	Homo sapiens	79-86
2540318-4	1989	On application of norepinephrine, phenylephrine (alpha-1 adrenergic agonist) or clonidine (alpha-2 adrenergic agonist) the arteries contracted in a dose-dependent manner and, in terms of the mean EC50 values, the order of potencies was clonidine greater than norepinephrine greater than phenylephrine.	Norepinephrine	18-32	adrenoceptor alpha 1D	Homo sapiens	49-56
2540318-4	1989	On application of norepinephrine, phenylephrine (alpha-1 adrenergic agonist) or clonidine (alpha-2 adrenergic agonist) the arteries contracted in a dose-dependent manner and, in terms of the mean EC50 values, the order of potencies was clonidine greater than norepinephrine greater than phenylephrine.	Norepinephrine	259-273	adrenoceptor alpha 1D	Homo sapiens	49-56
2540318-7	1989	Prazosin (selective alpha-1 adrenergic antagonist) depressed both the slope and maximal response of the control curve for norepinephrine but the shift was not significant.	Norepinephrine	122-136	adrenoceptor alpha 1D	Homo sapiens	20-27
2545937-6	1989	These results demonstrate that Met-Enk and Leu-Enk affected presynaptic sites of blood vessels and caused a decrease in electrically-stimulated norepinephrine release from the sympathetic nerve endings.	Norepinephrine	144-158	proenkephalin	Rattus norvegicus	35-38
2545937-6	1989	These results demonstrate that Met-Enk and Leu-Enk affected presynaptic sites of blood vessels and caused a decrease in electrically-stimulated norepinephrine release from the sympathetic nerve endings.	Norepinephrine	144-158	proenkephalin	Rattus norvegicus	47-50
2706916-1	1989	Neuropeptide Y (NPY) has recently been shown be co-released with noradrenaline (NA) from sympathetic nerves and to cause arterial vasoconstriction in experimental animals and man.	Norepinephrine	65-78	neuropeptide Y	Homo sapiens	0-14
2644003-0	1989	Limited responsiveness of LHRH neurons to norepinephrine may account for failure of locus coeruleus or medullary A1 electrical stimulation to increase plasma LH in estrogen-treated ovariectomized rats.	Norepinephrine	42-56	gonadotropin releasing hormone 1	Rattus norvegicus	26-30
2910096-3	1989	RESULTS: Under resting conditions, plasma NPY and norepinephrine levels were elevated in patients with CHF compared with control subjects (551 +/- 48 pg/ml versus 311 +/- 22 pg/ml, p less than or equal to 0.001 for NPY, and 306 +/- 73 pg/ml versus 124 +/- 22 pg/ml, p less than or equal to 0.02 for norepinephrine).	Norepinephrine	299-313	neuropeptide Y	Homo sapiens	42-45
2910096-4	1989	Plasma NPY correlated better with plasma norepinephrine than with epinephrine, indicating its origin from sympathetic nerve terminals.	Norepinephrine	41-55	neuropeptide Y	Homo sapiens	7-10
2545512-2	1989	Neuropeptide Y (NPY) potentiated the contractile responses induced by electrical transmural stimulation, noradrenaline and KCl in the rabbit mesenteric artery.	Norepinephrine	105-118	neuropeptide Y	Oryctolagus cuniculus	0-14
2545512-2	1989	Neuropeptide Y (NPY) potentiated the contractile responses induced by electrical transmural stimulation, noradrenaline and KCl in the rabbit mesenteric artery.	Norepinephrine	105-118	neuropeptide Y	Oryctolagus cuniculus	16-19
2545512-4	1989	In preparations treated with noradrenaline or KCl in Ca2+ free medium, NPY also potentiated the contractile response induced by resupplementation of Ca2+.	Norepinephrine	29-42	neuropeptide Y	Oryctolagus cuniculus	71-74
2566929-13	1989	These results are consistent with a beta 1-adrenoceptor-mediated relaxation caused by (-)-noradrenaline released from sympathetic nerve endings at low stimulation frequencies.	Norepinephrine	86-103	adrenoceptor beta 1	Bos taurus	36-55
2699758-5	1989	Neuropeptide Y (NPY) is coreleased with noradrenaline from perivascular sympathetic nerves.	Norepinephrine	40-53	neuropeptide Y	Homo sapiens	0-14
9629479-9	1998	Norepinephrine or angiotensin II induced a similar level of HSP72 expression in either cell source regardless of sampling time point.	Norepinephrine	0-14	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	60-65
9421421-1	1998	c-Fos/c-Jun dimers (activating protein-1 transcription factor) are involved in the modulatory actions of angiotensin II (Ang II) on brain norepinephrine neurons, effects mediated via Ang II type 1 (AT1) receptors.	Norepinephrine	138-152	angiotensin II receptor, type 1a	Rattus norvegicus	183-196
9421421-1	1998	c-Fos/c-Jun dimers (activating protein-1 transcription factor) are involved in the modulatory actions of angiotensin II (Ang II) on brain norepinephrine neurons, effects mediated via Ang II type 1 (AT1) receptors.	Norepinephrine	138-152	angiotensin II receptor, type 1a	Rattus norvegicus	198-201
2699758-5	1989	Neuropeptide Y (NPY) is coreleased with noradrenaline from perivascular sympathetic nerves.	Norepinephrine	40-53	neuropeptide Y	Homo sapiens	16-19
2699758-6	1989	NPY exerts prejunctional inhibitory actions on noradrenaline release and may also mediate non-adrenergic sympathetic vasoconstriction.	Norepinephrine	47-60	neuropeptide Y	Homo sapiens	0-3
2664885-5	1989	NPY seems to coexist with other on neurotransmitters like somatostatin, galanin, GABA and the catecholamines noradrenaline and adrenaline in discrete brain regions.	Norepinephrine	109-122	neuropeptide Y	Homo sapiens	0-3
9422359-4	1998	Although GTP cyclohydrolase I immunofluorescence within serotonin and norepinephrine neurons was relatively intense, the fluorescence signal within dopamine neurons was faint to nondetectable.	Norepinephrine	70-84	GTP cyclohydrolase 1	Homo sapiens	9-29
9422359-8	1998	Because dopamine and norepinephrine neurons express essentially equal amounts of GTP cyclohydrolase I mRNA, posttranscriptional events may serve to maintain low levels of GTP cyclohydrolase I protein within dopamine neurons.	Norepinephrine	21-35	GTP cyclohydrolase 1	Homo sapiens	171-191
9422390-2	1998	Raf-1-dependent activation of mitogen-activated protein kinase (MAPK) is the key in the chronic norepinephrine neuromodulatory actions of Ang II and is associated with the translocation of MAPK into the nucleus.	Norepinephrine	96-110	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	0-5
9861640-1	1998	Catechol-O-methyltransferase (COMT) catalyses the methylation, and hence the inactivation, of catecholamines including the neurotransmitters dopamine and noradrenaline.	Norepinephrine	154-167	catechol-O-methyltransferase	Homo sapiens	0-28
9861640-1	1998	Catechol-O-methyltransferase (COMT) catalyses the methylation, and hence the inactivation, of catecholamines including the neurotransmitters dopamine and noradrenaline.	Norepinephrine	154-167	catechol-O-methyltransferase	Homo sapiens	30-34
2905622-3	1988	The present electrophysiological study was undertaken to characterize the adrenoceptor mediating the suppressant effect of microiontophoretically applied norepinephrine (NE) on CA1 and CA3 dorsal hippocampus pyramidal neurons of the rat.	Norepinephrine	154-168	carbonic anhydrase 1	Rattus norvegicus	177-180
3253235-5	1988	During cross-country skiing, the average noradrenaline elimination (1166 pmol.min-1) was about 150% higher and the average adrenaline elimination (243 pmol.min-1) about 30% lower than during ski-flying.	Norepinephrine	41-54	SKI proto-oncogene	Homo sapiens	21-24
3253235-6	1988	The noradrenaline-adrenaline ratio was about 4.8 in cross-country skiing and 1.3-1.5 in ski-flying.	Norepinephrine	4-17	SKI proto-oncogene	Homo sapiens	66-69
2853756-4	1988	Exogenous neuropeptide Y reduced nerve stimulation-evoked noradrenaline overflow, possibly through a prejunctional mechanism, and caused dose-dependent vasoconstriction.	Norepinephrine	58-71	neuropeptide Y	Homo sapiens	10-24
3240025-2	1988	In addition, we have shown in vitro that these compounds are facile substrates for dopamine beta-hydroxylase, the terminal enzyme of norepinephrine synthesis.	Norepinephrine	133-147	dopamine beta-hydroxylase	Rattus norvegicus	83-108
3196916-4	1988	The effects of porcine NPY on norepinephrine-induced contraction of rabbit cerebral arteries were also studied in vitro.	Norepinephrine	30-44	neuropeptide Y	Oryctolagus cuniculus	23-26
3196916-5	1988	NPY (1.2 nM) caused a 3-fold potentiation of norepinephrine-induced contraction of cerebral arteries.	Norepinephrine	45-59	neuropeptide Y	Oryctolagus cuniculus	0-3
3196916-10	1988	In addition, NPY in CSF can potentiate the vasoconstrictor effect of norepinephrine which may contribute to the development of cerebral vasospasm.	Norepinephrine	69-83	neuropeptide Y	Oryctolagus cuniculus	13-16
3421335-2	1988	GRP injected into the third cerebral ventricle significantly (P less than 0.01) increased plasma epinephrine but not norepinephrine concentrations.	Norepinephrine	117-131	gastrin releasing peptide	Canis lupus familiaris	0-3
2978748-0	1988	Interaction between atrial natriuretic factor and ouabain: vascular reactivity to noradrenaline in pentobarbital anaesthetized dogs.	Norepinephrine	82-95	natriuretic peptide A	Canis lupus familiaris	20-45
3167696-0	1988	Dual role of norepinephrine in the hippocampal CA1 region of the rat: inhibition and disinhibition.	Norepinephrine	13-27	carbonic anhydrase 1	Rattus norvegicus	47-50
3167696-1	1988	Norepinephrine (NE) has been shown to produce either an inhibitory or an excitatory influence on CA1 pyramidal neurons of the hippocampus depending on the dosage.	Norepinephrine	0-14	carbonic anhydrase 1	Rattus norvegicus	97-100
3169195-4	1988	Bath application of noradrenaline, isoproterenol and histamine or a transient exposure to Mg++-free medium caused a long lasting increase in extracellularly recorded population spikes induced in CA1 by electrical stimulation of stratum radiatum.	Norepinephrine	20-33	carbonic anhydrase 1	Mus musculus	195-198
3138156-20	1988	These results suggest that the moderate enhancing effects of L-DOPS on MSR and PSR are due to conversion of L-DOPS to noradrenaline in the spinal cord.	Norepinephrine	118-131	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Rattus norvegicus	71-74
3125948-0	1987	Noradrenaline neuron plasticity in developing rat brain: effects of neonatal 6-hydroxydopamine demonstrated by dopamine-beta-hydroxylase immunocytochemistry.	Norepinephrine	0-13	dopamine beta-hydroxylase	Rattus norvegicus	111-136
2826755-12	1987	However, the inhibitory effect of a high concentration of captopril (5.0 microM) on beta-2 adrenoceptor-mediated facilitation of norepinephrine release remains to be clarified.	Norepinephrine	129-143	adrenoceptor beta 2	Rattus norvegicus	84-103
3509070-1	1987	Neuropeptide Y (a recently discovered brain peptide that is colocalized with norepinephrine within some adrenergic central nervous system neurons) was measured in the cerebrospinal fluid (CSF) from patients with major affective disorder, chronic schizophrenia, and in normal volunteers.	Norepinephrine	77-91	neuropeptide Y	Homo sapiens	0-14
2890806-0	1987	Endogenous restoration of noradrenaline by precursor therapy in dopamine-beta-hydroxylase deficiency.	Norepinephrine	26-39	dopamine beta-hydroxylase	Homo sapiens	64-89
9474769-3	1997	Substrate recycling occurs and the detection limit is in the lower nanomolar concentration range (e.g. 10 nM dopamine and 1 nM noradrenaline for the laccase- and glucose dehydrogenase-modified electrodes, respectively).	Norepinephrine	127-140	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	149-183
9421306-11	1997	NPY, PYY and PYY(3-36) inhibited [3H]-noradrenaline release from preparations of epididymis (pIC50 values 7.9+/-0.7, 9.6+/-0.8 and 10.0+/-0.9, respectively, all n=6).	Norepinephrine	38-51	peptide YY	Cavia porcellus	5-8
9421306-11	1997	NPY, PYY and PYY(3-36) inhibited [3H]-noradrenaline release from preparations of epididymis (pIC50 values 7.9+/-0.7, 9.6+/-0.8 and 10.0+/-0.9, respectively, all n=6).	Norepinephrine	38-51	peptide YY	Cavia porcellus	13-16
9389511-0	1997	Norepinephrine stimulates mitogen-activated protein kinase activity in GT1-1 gonadotropin-releasing hormone neuronal cell lines.	Norepinephrine	0-14	retinoic acid induced 1	Mus musculus	71-76
9432090-11	1997	We speculate that an increase in COMT-catalyzed O-methylation of CE may indicate that less COMT is available to deactivate norepinephrine.	Norepinephrine	123-137	catechol-O-methyltransferase	Homo sapiens	33-37
9432090-11	1997	We speculate that an increase in COMT-catalyzed O-methylation of CE may indicate that less COMT is available to deactivate norepinephrine.	Norepinephrine	123-137	catechol-O-methyltransferase	Homo sapiens	91-95
9388051-11	1997	We conclude that angiotensin-(1-7) is a component of the renin-angiotensin system that acts to modulate the pressor effects of angiotensin II and noradrenaline.	Norepinephrine	146-159	renin	Rattus norvegicus	57-62
9406118-0	1997	Effects of aldehyde/aldose reductase inhibition on neuronal metabolism of norepinephrine.	Norepinephrine	74-88	aldo-keto reductase family 1 member B1	Rattus norvegicus	20-36
9406118-1	1997	After norepinephrine (NE) is deaminated by monoamine oxidase (MAO), the aldehyde formed is either metabolized to 3,4-dihydroxy-mandelic acid (DHMA) by aldehyde dehydrogenase or is converted to 3,4-dihydroxyphenylglycol (DHPG) by aldehyde or aldose reductase.	Norepinephrine	6-20	monoamine oxidase A	Rattus norvegicus	43-60
9406118-1	1997	After norepinephrine (NE) is deaminated by monoamine oxidase (MAO), the aldehyde formed is either metabolized to 3,4-dihydroxy-mandelic acid (DHMA) by aldehyde dehydrogenase or is converted to 3,4-dihydroxyphenylglycol (DHPG) by aldehyde or aldose reductase.	Norepinephrine	6-20	monoamine oxidase A	Rattus norvegicus	62-65
9406118-1	1997	After norepinephrine (NE) is deaminated by monoamine oxidase (MAO), the aldehyde formed is either metabolized to 3,4-dihydroxy-mandelic acid (DHMA) by aldehyde dehydrogenase or is converted to 3,4-dihydroxyphenylglycol (DHPG) by aldehyde or aldose reductase.	Norepinephrine	6-20	aldo-keto reductase family 1 member B1	Rattus norvegicus	241-257
9403317-4	1997	Norepinephrine and epinephrine operate through differential recruitment of alpha 2- and beta-AR subtypes on the basis of their relative affinity for the different subtypes (the relative order of affinity is alpha 2 &gt; beta 1 &gt; or = beta 2 &gt; beta 3 for norepinephrine).	Norepinephrine	0-14	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	237-243
9326944-2	1997	MAOA preferentially oxidizes serotonin (5-hydroxytryptamine, or 5-HT) and norepinephrine (NE), whereas MAOB preferentially oxidizes beta-phenylethylamine (PEA).	Norepinephrine	74-88	monoamine oxidase A	Mus musculus	0-4
2890807-0	1987	Effect of unnatural noradrenaline precursor on sympathetic control and orthostatic hypotension in dopamine-beta-hydroxylase deficiency.	Norepinephrine	20-33	dopamine beta-hydroxylase	Homo sapiens	98-123
2890807-1	1987	A patient with severe orthostatic hypotension due to dopamine-beta-hydroxylase deficiency was treated with the unnatural aminoacid D,L-threo-3,4-dihydroxyphenylserine (DOPS) in the hope that it would serve as a substrate of aromatic-L-aminoacid decarboxylase to produce (-)-noradrenaline.	Norepinephrine	270-287	dopamine beta-hydroxylase	Homo sapiens	53-78
3319049-7	1987	The balance of norepinephrine to epinephrine found in vesicles in these terminals would be a function of intraneuronal PNMT activity, MAO activity and reuptake which would be the major regulator of intraneuronal norepinephrine concentrations.	Norepinephrine	15-29	phenylethanolamine-N-methyltransferase	Rattus norvegicus	119-123
3319049-7	1987	The balance of norepinephrine to epinephrine found in vesicles in these terminals would be a function of intraneuronal PNMT activity, MAO activity and reuptake which would be the major regulator of intraneuronal norepinephrine concentrations.	Norepinephrine	212-226	phenylethanolamine-N-methyltransferase	Rattus norvegicus	119-123
2960721-0	1987	CSF dopamine increased in depression: CSF dopamine, noradrenaline and their metabolites in depressed patients and in controls.	Norepinephrine	52-65	colony stimulating factor 2	Homo sapiens	0-3
2890722-3	1987	Previous work has shown that norepinephrine administration inhibits melatonin biosynthesis, as measured by the activity of the enzyme serotonin N-acetyltransferase.	Norepinephrine	29-43	aralkylamine N-acetyltransferase	Gallus gallus	134-163
9352569-1	1997	Catechol-O-methyltransferase catalyses the O-methylation of biologically active or toxic catechols and is a major component of the metabolism of drugs and neurotransmitters such as L-dopa, noradrenaline, adrenaline, and dopamine.	Norepinephrine	189-202	catechol-O-methyltransferase	Homo sapiens	0-28
2887563-5	1987	Studies with selective alpha 1-, alpha 2-, and beta-adrenergic agents indicated that norepinephrine was acting through alpha 1-adrenergic receptors.	Norepinephrine	85-99	adrenoceptor alpha 1D	Homo sapiens	23-40
2887563-5	1987	Studies with selective alpha 1-, alpha 2-, and beta-adrenergic agents indicated that norepinephrine was acting through alpha 1-adrenergic receptors.	Norepinephrine	85-99	adrenoceptor alpha 1D	Homo sapiens	23-30
2887563-13	1987	These findings suggest that pineal phospholipase A2 activity is controlled by norepinephrine acting via an alpha 1-adrenergic mechanism which might involve Ca2+ and protein kinase C.	Norepinephrine	78-92	adrenoceptor alpha 1D	Homo sapiens	107-114
3683592-6	1987	The kCOMT values for all four catecholamines, (-)-noradrenaline, dopamine, (-)-adrenaline and (+/-)-isoprenaline exhibit a range from 0.24 to 0.78 min-1; the metabolism of the catecholamines by the COMT differs: (-)-noradrenaline = dopamine less than (-)-adrenaline less than (+/-)-isoprenaline.	Norepinephrine	212-229	catechol-O-methyltransferase	Rattus norvegicus	5-9
2820553-4	1987	These results suggest that the effects of ascorbic acid on the in vitro release of LHRH are mediated by endogenous norepinephrine.	Norepinephrine	115-129	gonadotropin releasing hormone 1	Rattus norvegicus	83-87
9314422-2	1997	Basal norepinephrine spillover was significantly higher in patients with heart failure (1.3+/-0.3 microg/min) than in control subjects (0.7+/-0.1 microg/min, P=.05).	Norepinephrine	6-20	H3 histone pseudogene 4	Homo sapiens	158-163
9288680-10	1997	Noradrenaline (10 microM) increased the adenosine concentration measured in the presence of 100 microM AMP (i.e. the activity of ecto-5"-nucleotidase) by 38.7 +/- 9.6% (n = 5, P &lt; 0.05), an increase which was inhibited by an antagonist of the alpha 1-adrenoceptor (prazosin, 50 microM) or of PKC (chelerythrine, 10 microM).	Norepinephrine	0-13	5' nucleotidase, ecto	Rattus norvegicus	129-149
2442533-3	1987	Following exposure of coronary arteries to 30 nM NPY, the potencies of norepinephrine (in the presence of 3 microM timolol) and histamine in causing contraction were increased twofold, with no change in maximal contraction.	Norepinephrine	71-85	neuropeptide Y	Oryctolagus cuniculus	49-52
2442533-4	1987	After half-maximal contraction of coronary arteries with histamine and addition of 30 nM NPY, relaxation produced by norepinephrine (in the presence of 3 microM phentolamine), adenosine, and acetylcholine was inhibited.	Norepinephrine	117-131	neuropeptide Y	Oryctolagus cuniculus	89-92
2824105-4	1987	Under in vitro conditions activation of alpha 1-, alpha 2-, prostaglandin, adenosine, dopamine and serotonin receptors inhibits noradrenaline release from the kidney.	Norepinephrine	128-141	adrenoceptor alpha 1D	Homo sapiens	40-57
9178880-12	1997	In conclusion, mutual interactions occur between the presynaptic H3 and EP3 receptors involved in the inhibition of noradrenaline release in the mouse brain cortex.	Norepinephrine	116-129	prostaglandin E receptor 3 (subtype EP3)	Mus musculus	72-75
9194512-3	1997	These studies describe the effects of hBNP in New Zealand White rabbits in normotensive and acute norepinephrine-induced hypertensive states.	Norepinephrine	98-112	natriuretic peptide B	Homo sapiens	38-42
2824105-7	1987	Moreover, neuronally released noradrenaline inhibits its own release through activation of both prejunctional alpha 1- and alpha 2-adrenoceptors.	Norepinephrine	30-43	adrenoceptor alpha 1D	Homo sapiens	110-117
9194512-7	1997	In rabbits with norepinephrine-induced acute hypertension, bolus and continuous infusion of hBNP markedly reduced blood pressure.	Norepinephrine	16-30	natriuretic peptide B	Homo sapiens	92-96
2824105-9	1987	Locally produced PGE2, which is formed and released via stimulation of postjunctional alpha 1-adrenoceptors, as well as adenosine, released from postjunctional sites by renal nerve stimulation (RNS), seems to inhibit noradrenaline release through their specific prejunctional receptor systems.	Norepinephrine	217-230	adrenoceptor alpha 1D	Homo sapiens	86-93
3805164-5	1987	Sequential immunostaining with antibodies toward dopamine-beta-hydroxylase (DBH) (an enzyme involved in the synthesis of noradrenaline) and NPY revealed an identical localization of DBH and NPY in nerve cell bodies in the superior cervical ganglion and in perivascular fibers of pial blood vessels, suggesting their coexistence.	Norepinephrine	121-134	dopamine beta-hydroxylase	Rattus norvegicus	49-74
9190864-7	1997	In conclusion, the results shown in the present paper indicate that the potencies of different alpha-1 antagonists against the contractions induced by norepinephrine on tissues of the lower urinary tract of rabbits and dogs are better correlated with their affinity for the putative alpha-1L subtype than for the alpha-1a subtype.	Norepinephrine	151-165	adrenoceptor alpha 1A	Canis lupus familiaris	313-321
3805164-5	1987	Sequential immunostaining with antibodies toward dopamine-beta-hydroxylase (DBH) (an enzyme involved in the synthesis of noradrenaline) and NPY revealed an identical localization of DBH and NPY in nerve cell bodies in the superior cervical ganglion and in perivascular fibers of pial blood vessels, suggesting their coexistence.	Norepinephrine	121-134	dopamine beta-hydroxylase	Rattus norvegicus	76-79
2455181-6	1987	Cardiac tissues were weighed and subsequently analyzed for activities of tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH), two enzymes catalyzing the biosynthesis of catecholamines (CAs), and of choline acetyltransferase (CAT), a marker of parasympathetic activity, as well as for norepinephrine (NE).	Norepinephrine	294-308	dopamine beta-hydroxylase	Cavia porcellus	130-133
9137915-5	1997	The alpha 1A-adrenoceptor antagonist, 2-(2,6-dimethoxyphenoxyethyl) aminomethyl-1,4-benzodioxane (WB 4101), competitively inhibited norepinephrine-induced contractile responses in the ovine uterine artery and umbilical vein with intermediate pA2 values of 8.30 and 8.45, respectively.	Norepinephrine	132-146	adrenoceptor alpha 1A	Homo sapiens	4-25
9139974-0	1997	Modulation of SERCA2 expression by thyroid hormone and norepinephrine in cardiocytes: role of contractility.	Norepinephrine	55-69	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	14-20
9139974-2	1997	We investigated the contractility dependence of the effects of norepinephrine (NE) and thyroid hormone (T3) on SERCA2 expression in cultured neonatal heart cells under serum-free conditions.	Norepinephrine	63-77	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	111-117
9088867-6	1997	WB 4101 (alpha 1A-adrenoceptor antagonist) produced a major reduction in phase-1 of the [Ca2+]i response to noradrenaline, a lesser reduction of phase-2 of the [Ca2+]i response to noradrenaline and least reduction of contraction.	Norepinephrine	108-121	adrenoceptor alpha 1A	Rattus norvegicus	9-30
9088867-6	1997	WB 4101 (alpha 1A-adrenoceptor antagonist) produced a major reduction in phase-1 of the [Ca2+]i response to noradrenaline, a lesser reduction of phase-2 of the [Ca2+]i response to noradrenaline and least reduction of contraction.	Norepinephrine	180-193	adrenoceptor alpha 1A	Rattus norvegicus	9-30
9088867-7	1997	Chlorethylclonidine (alpha 1B-adrenoceptor antagonist) reduced phase-1 and phase-2 of the [Ca2+]i response and contraction to noradrenaline to a similar degree.	Norepinephrine	126-139	adrenoceptor alpha 1B	Rattus norvegicus	21-42
9075465-1	1997	BACKGROUND: We have previously reported an increase in symptoms of anxiety in patients with posttraumatic stress disorder (PTSD) following administration of the beta 2-antagonist yohimbine, which stimulates brain norepinephrine release.	Norepinephrine	213-227	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	161-167
2455193-2	1987	Neuropeptide Y is stored in large dense-cored vesicles and coreleased with noradrenaline (NA) from postganglionic, sympathetic nerves, and with adrenaline (ADR) from the adrenal medulla.	Norepinephrine	75-88	neuropeptide Y	Homo sapiens	0-14
9083230-12	1997	In the norepinephrine-dobutamine group pHi (from 7.30 +/- 0.11 to 7.35 +/- 0.07) and the PCO2 gap (from 10 +/- 3.0 to 4 +/- 2.0 mmHg) were normalized within 6 h (p &lt; 0.01).	Norepinephrine	7-21	glucose-6-phosphate isomerase	Homo sapiens	39-42
9530436-10	1997	Norepinephrine (10(-6) M) increased LHRH release from the stalk-median eminence collected from the control animals, 30 h and 68 h after oestradiol benzoate treatment by 48, 78 and 73 percent, respectively.	Norepinephrine	0-14	gonadotropin releasing hormone 1	Sus scrofa	36-40
22358527-5	1997	The production of interferon-beta (IFN-beta) by MG-63 cells super-induced by Poly (I): Poly (C) was shown to decrease in a dose dependent manner upon the addition of 0.01-10 mug/ml of cortisol or noradrenaline (NA).	Norepinephrine	196-209	interferon beta 1	Homo sapiens	18-33
22358527-5	1997	The production of interferon-beta (IFN-beta) by MG-63 cells super-induced by Poly (I): Poly (C) was shown to decrease in a dose dependent manner upon the addition of 0.01-10 mug/ml of cortisol or noradrenaline (NA).	Norepinephrine	196-209	interferon beta 1	Homo sapiens	35-43
9393937-0	1997	Antagonism to noradrenaline-induced lethality in rats is related to affinity for the alpha1A-adrenoceptor subtype.	Norepinephrine	14-27	adrenoceptor alpha 1A	Rattus norvegicus	85-105
9393937-2	1997	The potency of the tested compounds as antagonists of noradrenaline-induced lethality was correlated with the affinity for the alpha1A- (and alpha1a-) adrenoceptor subtype, but not with the affinity for the other subtypes.	Norepinephrine	54-67	adrenoceptor alpha 1A	Rattus norvegicus	141-163
9414459-3	1997	This review documents recent progress in understanding the role of noradrenaline within the GnRH network and highlights and explains its "enabling" or permissive characteristics.	Norepinephrine	67-80	gonadotropin releasing hormone 1	Homo sapiens	92-96
9414459-4	1997	Network behaviour analysis suggests that noradrenaline should be considered as a permissive agent promoting high output states of the GnRH network.	Norepinephrine	41-54	gonadotropin releasing hormone 1	Homo sapiens	134-138
9414459-6	1997	In this manner, noradrenaline is likely to play a role in bringing about the increased GnRH messenger RNA expression and secretion necessary for ovulation.	Norepinephrine	16-29	gonadotropin releasing hormone 1	Homo sapiens	87-91
2455195-4	1987	Examples include the interactions of neuropeptide Y (NPY) with noradrenaline (NA) and adenosine 5"-triphosphate (ATP) released from some sympathetic nerves; vasoactive intestinal polypeptide (VIP) with acetylcholine (ACh) released from some parasympathetic nerves; and NPY and 5-hydroxytryptamine (5-HT) released from intracardiac neurones supplying coronary vessels.	Norepinephrine	63-76	neuropeptide Y	Homo sapiens	37-51
2455195-4	1987	Examples include the interactions of neuropeptide Y (NPY) with noradrenaline (NA) and adenosine 5"-triphosphate (ATP) released from some sympathetic nerves; vasoactive intestinal polypeptide (VIP) with acetylcholine (ACh) released from some parasympathetic nerves; and NPY and 5-hydroxytryptamine (5-HT) released from intracardiac neurones supplying coronary vessels.	Norepinephrine	63-76	neuropeptide Y	Homo sapiens	53-56
3320555-3	1987	We have found that the diurnal pattern of norepinephrine turnover is altered in critical hypothalamic areas known to regulate the release of LHRH.	Norepinephrine	42-56	gonadotropin releasing hormone 1	Rattus norvegicus	141-145
3777218-1	1986	Fetal lambs treated with sheep anti-mouse nerve growth factor antibodies (anti-NGF) at 80 days gestation subsequently showed a diminished cardiovascular response to intravenous infusion of tyramine (1 mg/min over 10 min) and no significant change in plasma norepinephrine concentrations as measured by reversed-phase high-pressure liquid chromatography and electrochemical detection.	Norepinephrine	257-271	beta-nerve growth factor	Ovis aries	79-82
2431650-2	1986	Pharmacological experiments on isolated temporal artery segments revealed that NPY potentiated the vasoconstrictor responses to noradrenaline, but had no vasoconstrictor ability or only a small vasoconstrictor ability per se.	Norepinephrine	128-141	neuropeptide Y	Homo sapiens	79-82
8971795-4	1996	These results indicate that the effects of serotonergic antidepressant drugs (but not those of desipramine, which mainly blocks noradrenaline reuptake) can be potentiated by 5-HT1A autoreceptor blockade.	Norepinephrine	128-141	5-hydroxytryptamine receptor 1A	Rattus norvegicus	174-180
8914926-1	1996	Monoamine oxidases A/B (EC 1.4.3.4, MAO), flavoenzymes located on the outer mitochondrial membrane, catalyze the oxidative deamination of biogenic amines, such as dopamine, serotonin, and norepinephrine.	Norepinephrine	188-202	monoamine oxidase A	Rattus norvegicus	0-22
8914926-1	1996	Monoamine oxidases A/B (EC 1.4.3.4, MAO), flavoenzymes located on the outer mitochondrial membrane, catalyze the oxidative deamination of biogenic amines, such as dopamine, serotonin, and norepinephrine.	Norepinephrine	188-202	monoamine oxidase A	Rattus norvegicus	36-39
8945673-7	1996	In tension-recording studies, isolated segments of HSV exposed to 100 nM norepinephrine contracted further during progressive block of KCa channels by 0.1-3 mM TEA, suggesting that KCa channels are pathways for repolarization and vasodilation in HSV smooth muscle cells.	Norepinephrine	73-87	casein kappa	Homo sapiens	135-138
8945673-7	1996	In tension-recording studies, isolated segments of HSV exposed to 100 nM norepinephrine contracted further during progressive block of KCa channels by 0.1-3 mM TEA, suggesting that KCa channels are pathways for repolarization and vasodilation in HSV smooth muscle cells.	Norepinephrine	73-87	casein kappa	Homo sapiens	181-184
8957248-7	1996	Our data confirm that noradrenaline can be released by activation of 5-HT1A receptors but show that these receptors are not tonically activated, and may be more sensitive to stimulation than classical postsynaptic 5-HT1a receptors.	Norepinephrine	22-35	5-hydroxytryptamine receptor 1A	Rattus norvegicus	69-75
3024031-16	1986	Angiotensin II, synthesized in response to beta 2-adrenoceptor activation, probably stimulates angiotensin receptors on the noradrenergic nerves, leading to an increase in noradrenaline release.	Norepinephrine	172-185	adrenoceptor beta 2	Rattus norvegicus	43-62
3020540-7	1986	Norepinephrine-stimulated arachidonic acid release but not inositol phosphate formation was also inhibited by decreased extracellular calcium and by TMB-8, suggesting a role for a phospholipase A2.	Norepinephrine	0-14	phospholipase A2 group IB	Rattus norvegicus	180-196
8900127-5	1996	Norepinephrine triggered GLUT4 translocation in cells expressing the Gq-coupled alpha1-adrenergic receptor, but prostaglandin E2 did not cause GLUT4 translocation in cells expressing the Gs-coupled EP4 receptor or the Gi-coupled EP3alpha receptor.	Norepinephrine	0-14	solute carrier family 2 member 4	Homo sapiens	25-30
8897928-2	1996	After exposure to norepinephrine (NE; 0.2 microM) for 24 h, the manganese superoxide dismutase (Mn-SOD) content and activity in the cells were increased from 0.61 +/- 0.03 to 0.87 +/- 0.04 microgram/dish and 22 +/- 1 to 55 +/- 4 U/dish, respectively.	Norepinephrine	18-32	superoxide dismutase 2	Homo sapiens	64-94
2877020-10	1986	It is concluded that all of the effects of splanchnic nerve stimulation on insulin and PP secretion can be explained by interactions of norepinephrine with excitatory beta-receptors on PP-cells and inhibitory receptors on the insulin cells.	Norepinephrine	136-150	pancreatic polypeptide	Sus scrofa	87-89
8897928-2	1996	After exposure to norepinephrine (NE; 0.2 microM) for 24 h, the manganese superoxide dismutase (Mn-SOD) content and activity in the cells were increased from 0.61 +/- 0.03 to 0.87 +/- 0.04 microgram/dish and 22 +/- 1 to 55 +/- 4 U/dish, respectively.	Norepinephrine	18-32	superoxide dismutase 2	Homo sapiens	96-102
2877020-10	1986	It is concluded that all of the effects of splanchnic nerve stimulation on insulin and PP secretion can be explained by interactions of norepinephrine with excitatory beta-receptors on PP-cells and inhibitory receptors on the insulin cells.	Norepinephrine	136-150	pancreatic polypeptide	Sus scrofa	185-187
3014117-1	1986	The contractile response of vascular smooth muscle to l-norepinephrine is mediated almost exclusively by alpha-1 adrenoceptors in some blood vessels, and by a mixture of alpha-1 and postsynaptic alpha-2 receptors in others.	Norepinephrine	54-70	adrenoceptor alpha 1D	Homo sapiens	105-112
8902889-1	1996	Catechol-O-methyl transferase (COMT) metabolizes a variety of catecholamines such as dopamine, adrenaline and noradrenaline.	Norepinephrine	110-123	catechol-O-methyltransferase	Homo sapiens	0-29
8902889-1	1996	Catechol-O-methyl transferase (COMT) metabolizes a variety of catecholamines such as dopamine, adrenaline and noradrenaline.	Norepinephrine	110-123	catechol-O-methyltransferase	Homo sapiens	31-35
3014117-1	1986	The contractile response of vascular smooth muscle to l-norepinephrine is mediated almost exclusively by alpha-1 adrenoceptors in some blood vessels, and by a mixture of alpha-1 and postsynaptic alpha-2 receptors in others.	Norepinephrine	54-70	adrenoceptor alpha 1D	Homo sapiens	170-177
3014117-2	1986	To learn the sensitivity of the Schild plot as a test for the presence of more than one receptor type in such tissues, we constructed the plots to be expected from the dissociation constants of l-norepinephrine and prazosin for alpha-1 and alpha-2 adrenoceptors, using values determined by radioligand methods, and examining the effects of varying the proportions of the two types.	Norepinephrine	194-210	adrenoceptor alpha 1D	Homo sapiens	228-235
8765467-7	1996	Cells treated with pioglitazone for 48 hr, with norepinephrine added during the last 7 hr, demonstrated a 59-fold increase in UCP mRNA.	Norepinephrine	48-62	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	126-129
8765467-8	1996	However, simultaneous treatment with pioglitazone and repeated treatment norepinephrine for 48 hr yielded a greater than 200-fold increase in UCP mRNA.	Norepinephrine	73-87	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	142-145
8765467-9	1996	Examination of UCP protein levels demonstrated a similar time-dependent increase with pioglitazone and/or norepinephrine treatment, as well as a synergistic increase with concurrent pioglitazone and norepinephrine treatment.	Norepinephrine	106-120	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	15-18
8765467-9	1996	Examination of UCP protein levels demonstrated a similar time-dependent increase with pioglitazone and/or norepinephrine treatment, as well as a synergistic increase with concurrent pioglitazone and norepinephrine treatment.	Norepinephrine	199-213	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	15-18
8760369-3	1996	The two RA isomers displayed similar effectiveness as UCP inducers, their effect being comparable with that triggered by noradrenaline, so far considered to be the main modulator of UCP gene expression.	Norepinephrine	121-134	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	182-185
8702430-4	1996	A similar rise in GRF receptor gene expression was obtained by the depletion of noradrenaline, a neurotransmitter thought to stimulate GRF release, and was reversed by 87% by the repeated administration of synthetic GRF.	Norepinephrine	80-93	growth hormone releasing hormone	Rattus norvegicus	18-21
8702430-4	1996	A similar rise in GRF receptor gene expression was obtained by the depletion of noradrenaline, a neurotransmitter thought to stimulate GRF release, and was reversed by 87% by the repeated administration of synthetic GRF.	Norepinephrine	80-93	growth hormone releasing hormone	Rattus norvegicus	135-138
8814607-0	1996	Noradrenaline transport and transporter mRNA of rat chromaffin cells are controlled by dexamethasone and nerve growth factor.	Norepinephrine	0-13	nerve growth factor	Rattus norvegicus	105-124
8901462-7	1996	The catecholamines isoproterenol and norepinephrine stimulated the activity of myocardial G-6-PD in a time- and dose-dependent manner.	Norepinephrine	37-51	glucose-6-phosphate dehydrogenase	Rattus norvegicus	90-96
8797083-4	1996	Although the lipid droplets did not exhibit specific (-)-[3H]DHA binding, norepinephrine induced lipolysis in a cell-free system consisting of the lipid droplets and hormone-sensitive lipase (HSL).	Norepinephrine	74-88	lipase E, hormone sensitive type	Rattus norvegicus	166-190
8797083-4	1996	Although the lipid droplets did not exhibit specific (-)-[3H]DHA binding, norepinephrine induced lipolysis in a cell-free system consisting of the lipid droplets and hormone-sensitive lipase (HSL).	Norepinephrine	74-88	lipase E, hormone sensitive type	Rattus norvegicus	192-195
3532055-0	1986	Norepinephrine stimulates LH-RH secretion into the hypophysial portal blood of the rat.	Norepinephrine	0-14	gonadotropin releasing hormone 1	Rattus norvegicus	26-31
8780020-8	1996	We conclude that calmodulin plays an important role in vesicular noradrenaline release, probably by activating Ca2+/calmodulin-dependent enzymes involved in the regulation of one or more steps in the release mechanism.	Norepinephrine	65-78	calmodulin 1	Rattus norvegicus	17-27
8780020-8	1996	We conclude that calmodulin plays an important role in vesicular noradrenaline release, probably by activating Ca2+/calmodulin-dependent enzymes involved in the regulation of one or more steps in the release mechanism.	Norepinephrine	65-78	calmodulin 1	Rattus norvegicus	116-126
8738299-1	1996	We have reported that chronic treatment of patients with beta 1-adrenoceptor blockers sensitises isolated atrial preparations to adrenaline, noradrenaline and 5-Ht.	Norepinephrine	141-154	adrenoceptor beta 1	Homo sapiens	57-76
3532055-1	1986	The present study was designed to investigate the effect of intracerebroventricular infusion of norepinephrine (NE) on the secretion of luteinizing hormone-releasing hormone (LH-RH) into the hypophysial portal blood of steroid-primed ovariectomized rats.	Norepinephrine	96-110	gonadotropin releasing hormone 1	Rattus norvegicus	136-173
3532055-1	1986	The present study was designed to investigate the effect of intracerebroventricular infusion of norepinephrine (NE) on the secretion of luteinizing hormone-releasing hormone (LH-RH) into the hypophysial portal blood of steroid-primed ovariectomized rats.	Norepinephrine	96-110	gonadotropin releasing hormone 1	Rattus norvegicus	175-180
3755439-1	1986	Neuropeptide Y (NPY) has recently been reported to coexist with noradrenaline (NA) in central as well as peripheral noradrenergic nerves.	Norepinephrine	64-77	neuropeptide Y	Homo sapiens	0-14
8730741-5	1996	Furthermore, the ability of an inhibitor of nitric oxide synthase (NOS), NG-nitro-L-arginine methyl ester (L-NAME, 1-300 microM), to enhance the contractile reactivity to a submaximal concentration of noradrenaline (NA, 3 microM), was significantly attenuated in hypercholesterolaemia.	Norepinephrine	201-214	nitric oxide synthase, brain	Oryctolagus cuniculus	44-65
3755439-1	1986	Neuropeptide Y (NPY) has recently been reported to coexist with noradrenaline (NA) in central as well as peripheral noradrenergic nerves.	Norepinephrine	64-77	neuropeptide Y	Homo sapiens	16-19
3755659-1	1986	Neuropeptide Y (NPY) is colocalised with noradrenaline in post-ganglionic sympathetic neurons.	Norepinephrine	41-54	neuropeptide Y	Homo sapiens	0-14
3755659-1	1986	Neuropeptide Y (NPY) is colocalised with noradrenaline in post-ganglionic sympathetic neurons.	Norepinephrine	41-54	neuropeptide Y	Homo sapiens	16-19
8612391-14	1996	Other mechanisms are capable of regulating the concentrations of norepinephrine and epinephrine in circulating blood (and apparently also at receptors in the heart and vascular tissue) when both COMT and MAO-A activity are inhibited to a significant extent.	Norepinephrine	65-79	catechol-O-methyltransferase	Homo sapiens	195-199
3755659-7	1986	The increase in NPY correlated with the increase in noradrenaline, suggesting that NPY may be released with noradrenaline when sympathetic noradrenergic nerves are activated.	Norepinephrine	52-65	neuropeptide Y	Homo sapiens	16-19
3755659-7	1986	The increase in NPY correlated with the increase in noradrenaline, suggesting that NPY may be released with noradrenaline when sympathetic noradrenergic nerves are activated.	Norepinephrine	52-65	neuropeptide Y	Homo sapiens	83-86
3755659-7	1986	The increase in NPY correlated with the increase in noradrenaline, suggesting that NPY may be released with noradrenaline when sympathetic noradrenergic nerves are activated.	Norepinephrine	108-121	neuropeptide Y	Homo sapiens	16-19
3755659-7	1986	The increase in NPY correlated with the increase in noradrenaline, suggesting that NPY may be released with noradrenaline when sympathetic noradrenergic nerves are activated.	Norepinephrine	108-121	neuropeptide Y	Homo sapiens	83-86
2873241-0	1986	Actions of noradrenaline recorded intracellularly in rat hippocampal CA1 pyramidal neurones, in vitro.	Norepinephrine	11-24	carbonic anhydrase 1	Rattus norvegicus	69-72
3008207-7	1986	As both serotonin and norepinephrine are preferentially metabolized by MAO-A rather than MAO-B, an increased availability of serotonin (the precursor of melatonin) or enhanced noradrenergic function might mediate the melatonin changes observed to follow MAO-A but not MAO-B inhibition.	Norepinephrine	22-36	monoamine oxidase A	Homo sapiens	71-76
3008207-7	1986	As both serotonin and norepinephrine are preferentially metabolized by MAO-A rather than MAO-B, an increased availability of serotonin (the precursor of melatonin) or enhanced noradrenergic function might mediate the melatonin changes observed to follow MAO-A but not MAO-B inhibition.	Norepinephrine	22-36	monoamine oxidase A	Homo sapiens	254-259
3010387-9	1986	NPY and PYY potentiated the response to noradrenaline in the artery, as well as the response to histamine in the vein.	Norepinephrine	40-53	neuropeptide Y	Oryctolagus cuniculus	0-3
3942277-0	1986	CSF noradrenaline and schizophrenia.	Norepinephrine	4-17	colony stimulating factor 2	Homo sapiens	0-3
2434059-2	1986	There is a good correlation between DDT-induced tremor and an increase in the levels of the metabolites of norepinephrine (NE), serotonin (5HT) and, to a lesser extent, dopamine (DA) in the brain stem (BS), hypothalamus (HYP), striatum (STR), or hippocampus (HPC).	Norepinephrine	107-121	D-dopachrome tautomerase	Rattus norvegicus	36-39
3721190-4	1986	Adrenaline and noradrenaline proved to be even more effective in increasing splenic ODC activity than isoproterenol.	Norepinephrine	15-28	ornithine decarboxylase 1	Rattus norvegicus	84-87
8656042-5	1996	However, when the artery was pretreated with norepinephrine (1000 nmol/L) for 10 minutes, followed by a basal-medium washout that left a 13% norepinephrine-induced flow inhibition, 0.05 to 5 mmol/L SCN- caused a marked flow rate reduction of between 20.4% +/- 9.8% and 28.0% +/- 21.8%, as calculated for the entire test perfusion.	Norepinephrine	45-59	sodium voltage-gated channel alpha subunit 2	Rattus norvegicus	198-201
8656042-9	1996	We conclude that SCN- amplifies the norepinephrine-induced vascular smooth muscle tone and that this may be caused by an altered calcium channel activity.	Norepinephrine	36-50	sodium voltage-gated channel alpha subunit 2	Rattus norvegicus	17-20
8861784-9	1996	Isoprenaline, noradrenaline, and adrenaline were almost full agonists in both cell types (intrinsic activity from 74% or 95%) during combined beta 1, beta 2- and alpha 2-adrenoceptor blockade.	Norepinephrine	14-27	adrenoceptor beta 1	Homo sapiens	142-182
8849631-6	1996	Increases in norepinephrine levels and in diastolic blood pressure were nonsignificantly related to increases in BTG levels (ps &lt; .10), whereas increases in epinephrine levels were unrelated.	Norepinephrine	13-27	pro-platelet basic protein	Homo sapiens	113-116
9011760-4	1996	These results suggest that the hypertension of SHR may be related to the high activity of TH due to the high level of TH mRNA which increases norepinephrine levels in the medulla oblongata.	Norepinephrine	142-156	tyrosine hydroxylase	Rattus norvegicus	90-92
9011760-4	1996	These results suggest that the hypertension of SHR may be related to the high activity of TH due to the high level of TH mRNA which increases norepinephrine levels in the medulla oblongata.	Norepinephrine	142-156	tyrosine hydroxylase	Rattus norvegicus	118-120
8654394-7	1996	Similar experiments using several adrenergic agonists revealed that Medaka alpha1A-AR responds to the following agonists in the order: epinephrine &gt; or = (-)norepinephrine &gt; oxymetazoline &gt; or = methoxamine, which is similar to the responses of rat alpha1A receptor expressed in COS cells.	Norepinephrine	160-174	adrenoceptor alpha 1A	Homo sapiens	75-85
8558260-0	1996	Vasoactive intestinal peptide, pituitary adenylate cyclase-activating peptide, and noradrenaline induce the transcription factors CCAAT/enhancer binding protein (C/EBP)-beta and C/EBP delta in mouse cortical astrocytes: involvement in cAMP-regulated glycogen metabolism.	Norepinephrine	83-96	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	130-160
8825367-0	1996	The role of diacylglycerol and activation of protein kinase C in alpha 1A-adrenoceptor-mediated contraction to noradrenaline of rat isolated epididymal vas deferens.	Norepinephrine	111-124	adrenoceptor alpha 1A	Rattus norvegicus	65-86
8833223-2	1996	The production of PLP from pyridoxal (PL) by pyridoxal kinase (PLK) was inhibited by the addition of dopamine (DA), norepinephrine (NE) and 5-hydroxytryptamine (5-HT), but not by that of epinephrine and N-acetyl-serotonin.	Norepinephrine	116-130	pyridoxal (pyridoxine, vitamin B6) kinase	Mus musculus	45-61
8833223-2	1996	The production of PLP from pyridoxal (PL) by pyridoxal kinase (PLK) was inhibited by the addition of dopamine (DA), norepinephrine (NE) and 5-hydroxytryptamine (5-HT), but not by that of epinephrine and N-acetyl-serotonin.	Norepinephrine	116-130	pyridoxal (pyridoxine, vitamin B6) kinase	Mus musculus	63-66
9014240-7	1996	This revised alpha 1a-adrenoceptor model accounts for direct interactions which are proposed between Ser 188 and Ser 192 and the meta and para hydroxyl groups of norepinephrine, respectively, in the G-protein coupled receptor state.	Norepinephrine	162-176	adrenoceptor alpha 1A	Homo sapiens	13-34
3096916-3	1986	Fluorescence microscopy of adjacent sections demonstrated that the cells stained for t-PA contained noradrenaline.	Norepinephrine	100-113	plasminogen activator, tissue type	Rattus norvegicus	85-89
8590997-28	1995	The present results indicate that NPY may play a role in the regulation of retinal blood flow through both a direct contractile action, independent of the vessel size and a potentiation of the responses induced by noradrenaline in the proximal part of the retinal circulation, both effects being mediated by Y1 receptors.	Norepinephrine	214-227	neuropeptide Y	Bos taurus	34-37
3018392-6	1986	Secondly, NPY has an indirect postjunctional effect in that it potentiates the response to various vasoconstrictors; this was studied on the rabbit femoral artery and vein, using noradrenaline and histamine, respectively, as vasoconstrictors.	Norepinephrine	179-192	neuropeptide Y	Oryctolagus cuniculus	10-13
3523279-6	1986	Furthermore, E2 enhanced the sensitivity and the responsiveness of LHRH terminals to norepinephrine (NE).	Norepinephrine	85-99	gonadotropin releasing hormone 1	Rattus norvegicus	67-71
8562484-0	1995	Norepinephrine stimulates the expression of fibroblast growth factor 2 in rat brown adipocyte primary culture.	Norepinephrine	0-14	fibroblast growth factor 2	Rattus norvegicus	44-70
8542674-0	1995	Whole body and renal noradrenaline release during acute infusion of endothelin-1 in conscious sheep.	Norepinephrine	21-34	EDN1	Ovis aries	68-80
2867766-2	1985	The ornithine decarboxylase inhibitor alpha-difluoromethylornithine blocked the K+-stimulated increase in enzyme activity and polyamines and also suppressed the increase in 45Ca2+ influx and efflux and the Ca2+-dependent release of GABA and norepinephrine.	Norepinephrine	241-255	ornithine decarboxylase 1	Rattus norvegicus	4-27
7669252-1	1995	The beta 2 adrenergic receptor (beta 2AR) plays a key role in the signal transduction mechanism for epinephrine and norepinephrine.	Norepinephrine	116-130	adrenoceptor beta 2	Macaca mulatta	4-30
7669252-1	1995	The beta 2 adrenergic receptor (beta 2AR) plays a key role in the signal transduction mechanism for epinephrine and norepinephrine.	Norepinephrine	116-130	adrenoceptor beta 2	Macaca mulatta	32-40
3910121-0	1985	Gonadotropin-releasing hormone release by superfused hypothalami in response to norepinephrine.	Norepinephrine	80-94	gonadotropin releasing hormone 1	Rattus norvegicus	0-30
3910121-7	1985	Norepinephrine stimulates the release of GnRH in a log-linear dose-dependent manner in the range of 10(-9) to 10(-5) M norepinephrine (NE).	Norepinephrine	0-14	gonadotropin releasing hormone 1	Rattus norvegicus	41-45
3910121-7	1985	Norepinephrine stimulates the release of GnRH in a log-linear dose-dependent manner in the range of 10(-9) to 10(-5) M norepinephrine (NE).	Norepinephrine	119-133	gonadotropin releasing hormone 1	Rattus norvegicus	41-45
2418289-0	1985	Competitive inhibition of acetylcholinesterase by bretylium: possible mechanism for its induction of norepinephrine release.	Norepinephrine	101-115	acetylcholinesterase	Rattus norvegicus	26-46
2418289-4	1985	It is suggested that inhibition of acetylcholinesterase activity by bretylium induces norepinephrine release through the effect of accumulated acetylcholine on nicotinic receptors in adrenergic nerve terminals.	Norepinephrine	86-100	acetylcholinesterase	Rattus norvegicus	35-55
4078744-11	1985	The secondary relaxation of arterial vessels reflects an inherent property of their smooth muscle to relax from the constrictor influence of noradrenaline and is more marked in proximal than distal vessels.	Norepinephrine	141-154	neurogenin 3	Rattus norvegicus	14-19
3914638-5	1985	It was also demonstrated, using correlative light microscopic immunostaining on serial sections and double electron microscopic immunocytochemistry, that C-PON and NPY immunoreactivities are co-localized in neuronal cell bodies of the brain cortex, sympathetic ganglion cells, norepinephrine-containing granules of the adrenal medulla and in human pheochromocytoma tumor cells.	Norepinephrine	277-291	neuropeptide Y	Homo sapiens	164-167
2863008-8	1985	Thus, in these human blood vessels, endogenously released norepinephrine does not preferentially activate postjunctional alpha 1-adrenoceptors, but activates receptors with the properties of both the alpha 1- and alpha 2-adrenoceptor subtypes.	Norepinephrine	58-72	adrenoceptor alpha 1D	Homo sapiens	200-207
7499722-7	1995	CORT decreased plasma levels and urinary excretion of norepinephrine (NE).	Norepinephrine	54-68	cortistatin	Rattus norvegicus	0-4
7582530-0	1995	Characterization of an alpha 1D-adrenoceptor mediating the contractile response of rat aorta to noradrenaline.	Norepinephrine	96-109	adrenoceptor alpha 1D	Rattus norvegicus	23-44
7792602-0	1995	Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA.	Norepinephrine	63-77	monoamine oxidase A	Mus musculus	94-98
7582494-2	1995	5-Hydroxytryptamine</compound-id> (5-HT) plays a role in the regulation of noradrenergic neurones in the brain, but the precise mechanism of regulation of noradrenaline (NA) release by 5-HT1A receptors has not been defined.	Norepinephrine	155-168	5-hydroxytryptamine receptor 1A	Rattus norvegicus	185-191
7643912-6	1995	Inhibition of MAO reduced the deamination of dopamine and noradrenaline by 99.8% and 98.6%, respectively, indicating that MAO, and not SSAO, was responsible for deamination of the catecholamines in the lungs.	Norepinephrine	58-71	monoamine oxidase A	Rattus norvegicus	14-17
7643912-6	1995	Inhibition of MAO reduced the deamination of dopamine and noradrenaline by 99.8% and 98.6%, respectively, indicating that MAO, and not SSAO, was responsible for deamination of the catecholamines in the lungs.	Norepinephrine	58-71	monoamine oxidase A	Rattus norvegicus	122-125
4059661-0	1985	Effects of phenylethanolamine N-methyltransferase inhibitors on uptake and release of norepinephrine and dopamine from rat brain.	Norepinephrine	86-100	phenylethanolamine-N-methyltransferase	Rattus norvegicus	11-49
2861818-2	1985	The influence has been studied of 11 phenothiazine drugs on the oxidation of the catecholamine neurotransmitters noradrenaline and dopamine, catalyzed by human ceruloplasmin.	Norepinephrine	113-126	ceruloplasmin	Homo sapiens	160-173
2862963-3	1985	Noradrenaline depletion in the cerebral cortex was obtained by peripheral injections of 6-hydroxydopamine (6-OHDA) at birth or N-2-chloroethyl-N-ethyl-2-bromobenzylamine (DSP4) at various postnatal ages and controlled by the absence of dopamine-beta-hydroxylase-labelled axons.	Norepinephrine	0-13	dopamine beta-hydroxylase	Rattus norvegicus	236-261
7697853-5	1995	Ecto-5"-nucleotidase activity was increased by norepinephrine and methoxamine during 30 minutes in a dose-dependent manner, whereas cytosolic 5"-nucleotidase was not activated.	Norepinephrine	47-61	5' nucleotidase, ecto	Rattus norvegicus	0-20
7697853-5	1995	Ecto-5"-nucleotidase activity was increased by norepinephrine and methoxamine during 30 minutes in a dose-dependent manner, whereas cytosolic 5"-nucleotidase was not activated.	Norepinephrine	47-61	5' nucleotidase, ecto	Rattus norvegicus	5-20
7733239-4	1995	Angiotensin II (ANG II) and norepinephrine (NE) each augmented up to threefold the expression and secretion of latent TGF-beta 1 and TGF-beta 2 and also induced a shift in isoform predominance from beta 1 to beta 2.	Norepinephrine	28-42	transforming growth factor, beta receptor 2	Rattus norvegicus	133-143
7887963-2	1995	In aortic rings precontracted with 0.3 microM norepinephrine PTHrP(1-34) caused a dose-dependent relaxation with the maximal response of 33% being observed at 10(-6) M. PTHrP was nearly equipotent to PTH or CGRP in the vasodilatory action.	Norepinephrine	46-60	calcitonin-related polypeptide alpha	Rattus norvegicus	207-211
7861143-0	1995	N-terminal-specific anti-B-50 (GAP-43) antibodies inhibit Ca(2+)-induced noradrenaline release, B-50 phosphorylation and dephosphorylation, and calmodulin binding.	Norepinephrine	73-86	growth associated protein 43	Rattus norvegicus	31-37
7861143-1	1995	B-50 (GAP-43) is a presynaptic protein kinase C (PKC) substrate implicated in the molecular mechanism of noradrenaline release.	Norepinephrine	105-118	growth associated protein 43	Rattus norvegicus	6-12
7861143-7	1995	We conclude that the N-terminal residues 39-43 of the rat B-50 protein play an important role in the process of Ca(2+)-induced noradrenaline release, presumably by serving as a local calmodulin store that is regulated in a Ca(2+)- and phosphorylation-dependent fashion.	Norepinephrine	127-140	calmodulin 1	Rattus norvegicus	183-193
3839723-0	1985	Increased sensitivity of rabbit ear artery to noradrenaline following perivascular nerve stimulation may be a response to neuropeptide Y released as cotransmitter.	Norepinephrine	46-59	neuropeptide Y	Oryctolagus cuniculus	122-136
7628838-1	1995	Catecholamines (adrenaline and noradrenaline) stimulate adipocyte lipolysis via three beta-adrenoceptor subtypes beta 1, beta 2 and beta 3.	Norepinephrine	31-44	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	121-138
3839723-1	1985	Neuropeptide Y (NPY 10(-10)-10(-7) mol/l) had little or no effect on the perfusion pressure of rabbit isolated ear arteries but potentiated the brief contractile responses to injections of noradrenaline, histamine or brief periods of electrical stimulation (2-20 Hz for 5 s).	Norepinephrine	189-202	neuropeptide Y	Oryctolagus cuniculus	0-14
3839723-1	1985	Neuropeptide Y (NPY 10(-10)-10(-7) mol/l) had little or no effect on the perfusion pressure of rabbit isolated ear arteries but potentiated the brief contractile responses to injections of noradrenaline, histamine or brief periods of electrical stimulation (2-20 Hz for 5 s).	Norepinephrine	189-202	neuropeptide Y	Oryctolagus cuniculus	16-19
4022136-3	1985	The dopamine-beta-hydroxylase inhibitor FLA-63 swiftly elevated the content of dopamine and it lowered the content of noradrenaline in the two noradrenaline regions, but it was ineffective in the substantia nigra.	Norepinephrine	118-131	dopamine beta-hydroxylase	Rattus norvegicus	4-29
4022136-3	1985	The dopamine-beta-hydroxylase inhibitor FLA-63 swiftly elevated the content of dopamine and it lowered the content of noradrenaline in the two noradrenaline regions, but it was ineffective in the substantia nigra.	Norepinephrine	143-156	dopamine beta-hydroxylase	Rattus norvegicus	4-29
2415951-1	1985	A wealth of evidence suggests that catecholamines (particularly norepinephrine) influence gonadotropin secretion via a direct interaction with the LHRH neurons.	Norepinephrine	64-78	gonadotropin releasing hormone 1	Mus musculus	147-151
2987762-3	1985	The extent to which noradrenaline evoked an increase in 2-[14C]DG labelling of glycogen was modified by both morphine and methionine-enkephalin.	Norepinephrine	20-33	proenkephalin	Rattus norvegicus	133-143
3920919-4	1985	In rings of femoral and pulmonary vein contracted with norepinephrine, arachidonic acid produced a concentration-dependent increase in tension that was eliminated by removal of the endothelium or by treatment with the inhibitors of cyclooxygenase (indomethacin, meclofenamate, or acetylsalicyclic acid).	Norepinephrine	55-69	prostaglandin-endoperoxide synthase 1	Canis lupus familiaris	232-246
3987067-1	1985	Fusaric acid, an inhibitor of dopamine beta-hydroxylase, which converts dopamine to noradrenaline, lowered the blood pressure and induced a subjective improvement in patients with phaeochromocytoma.	Norepinephrine	84-97	dopamine beta-hydroxylase	Homo sapiens	30-55
2984573-2	1985	Noradrenaline, released from sympathetic nerve terminals in the pineal gland, regulates a large nocturnal increase in melatonin synthesis by stimulating the activity of arylalkylamine N-acetyltransferase (NAT, EC 2.3.1.87) 30-70-fold.	Norepinephrine	0-13	aralkylamine N-acetyltransferase	Rattus norvegicus	169-203
2988261-1	1985	Noradrenaline (NA) exerts its physiological and pharmacological effects in the central nervous system by interacting with specific receptor sites which are divided into four subtypes, namely alpha-1, alpha-2, beta-1 and beta-2 adrenoceptors.	Norepinephrine	0-13	hemoglobin, beta adult major chain	Mus musculus	209-215
3973827-8	1985	Significant elevations of arterial plasma norepinephrine, epinephrine and dopamine occurred after T-2, with metabolic acidosis, hypocarbia and hyperoxemia in both conscious rats and guinea pigs.	Norepinephrine	42-56	brachyury 2	Rattus norvegicus	98-101
2579826-2	1985	The contractile response induced by norepinephrine in this tissue could be antagonized by prazosin, a selective alpha 1-antagonist, with a receptor dissociation constant (KB) of 4.0 +/- 0.9 nM.	Norepinephrine	36-50	adrenoceptor alpha 1D	Homo sapiens	112-119
2579826-4	1985	The irreversible alpha-antagonists benextramine and phenoxybenzamine, both of which preferentially inactivate the alpha 1-subtype, produced marked depression of norepinephrine-induced contraction.	Norepinephrine	161-175	adrenoceptor alpha 1D	Homo sapiens	114-121
3905724-1	1985	The aim of the present investigation was to study the distribution in the rat pineal gland of dopamine-beta-hydroxylase (DBH) which is essential for the formation of the melatonin synthesis-regulating substance noradrenaline (NA).	Norepinephrine	211-224	dopamine beta-hydroxylase	Rattus norvegicus	94-119
7674815-0	1995	The alpha 1d-adrenoceptor subtype is involved in the noradrenaline-induced contractions of rat aorta.	Norepinephrine	53-66	adrenoceptor alpha 1D	Rattus norvegicus	4-25
3905724-1	1985	The aim of the present investigation was to study the distribution in the rat pineal gland of dopamine-beta-hydroxylase (DBH) which is essential for the formation of the melatonin synthesis-regulating substance noradrenaline (NA).	Norepinephrine	211-224	dopamine beta-hydroxylase	Rattus norvegicus	121-124
2578061-1	1985	Significant amounts of acid-hydrolyzable conjugates of 3,4-dihydroxyphenylethylamine, norepinephrine, and 5-hydroxytryptamine were detected in lumbar CSF from 22 awake unpremedicated healthy individuals.	Norepinephrine	86-100	colony stimulating factor 2	Homo sapiens	150-153
4078568-3	1985	The disappearances of dopamine and noradrenaline after alpha-methyltyrosine and the disappearance of noradrenaline after inhibition of the dopamine-beta-hydroxylase were not changed by decentralization or stimulation.	Norepinephrine	101-114	dopamine beta-hydroxylase	Rattus norvegicus	139-164
2582215-2	1985	This article reviews the relationship between the turnover of the neurotransmitter monoamines noradrenaline, serotonin, and dopamine, and the concentrations in CSF of their principal metabolites, 3-methoxy-4-hydroxyphenylglycol (MHPG), 5-hydroxyindoleacetic acid (5-HIAA), and homovanillic acid (HVA).	Norepinephrine	94-107	colony stimulating factor 2	Homo sapiens	160-163
2984490-2	1985	GABA receptor agonists, by changing the firing rate of the corresponding neurons accelerate noradrenaline turnover without changes in postsynaptic receptor density and diminish serotonin liberation with an up-regulation of 5HT2 receptors.	Norepinephrine	92-105	GABA type A receptor-associated protein	Homo sapiens	0-13
20493019-0	1985	Involvement of phospholipase A(2) in norepinephrine release from synaptosomes isolated from rat cerebral cortex.	Norepinephrine	37-51	phospholipase A2 group IB	Rattus norvegicus	15-32
2580262-1	1985	We have investigated the possible associations between the demographic, clinical and psychological characteristics of 80 patients with low back pain and the CSF levels of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG), the principal central nervous system metabolites of serotonin, dopamine and noradrenaline, and of tryptophan, the amino acid precursor of serotonin.	Norepinephrine	352-365	colony stimulating factor 2	Homo sapiens	157-160
6096749-0	1984	Noradrenaline and prostaglandin E2 stimulate LH-RH release from rat median eminence through distinct 1-alpha-adrenergic and PGE2 receptors.	Norepinephrine	0-13	gonadotropin releasing hormone 1	Rattus norvegicus	45-50
6096749-1	1984	Noradrenaline (NA) and prostaglandin (PG) E2 produced a dose-related stimulation of luteinizing hormone releasing hormone (LH-RH) release from incubated median eminence of adult male rats, with ED50 values of 6.10(-7) and 8.10(-8) M, respectively.	Norepinephrine	0-13	gonadotropin releasing hormone 1	Rattus norvegicus	84-121
6096749-1	1984	Noradrenaline (NA) and prostaglandin (PG) E2 produced a dose-related stimulation of luteinizing hormone releasing hormone (LH-RH) release from incubated median eminence of adult male rats, with ED50 values of 6.10(-7) and 8.10(-8) M, respectively.	Norepinephrine	0-13	gonadotropin releasing hormone 1	Rattus norvegicus	123-128
6148107-9	1984	Adrenergic stimulation, either short-term (by diethyl ether stress) or long-term (by norepinephrine treatment), led to a lowered liver lipase activity.	Norepinephrine	85-99	lipase G, endothelial type	Rattus norvegicus	135-141
6095974-5	1984	Moreover, recent work from my laboratory indicates that in vitro at alkaline pH in the presence of Mg2+, the biologically active diphenols (beta-3,4-dihydroxyphenylalanine and the beta-adrenergic agonists isoproterenol, norepinephrine, and epinephrine) appear to function as electron donor substrates for human erythrocyte catalase and inhibit the production of O2 from H2O2 at micromolar concentrations.	Norepinephrine	220-234	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	140-148
7704341-4	1995	The results of numerical simulation show that: the addition of drugs that inhibit neuronal uptake and catechol-O-methyltransferase cause the augmentation of noradrenaline action on post-synaptic structures and an increase in the amplitude of the generated inhibitory post-synaptic potential (IPSP); treatment with adrenergic antagonists reduces the amplitude of IPSP; decrease in the concentration of extracellular Ca2+ ions and application of TTX abolish the post-synaptic response.	Norepinephrine	157-170	catechol-O-methyltransferase	Homo sapiens	102-130
7715741-0	1995	Prostanoid receptors of the EP3 subtype mediate the inhibitory effect of prostaglandin E2 on noradrenaline release in the mouse brain cortex.	Norepinephrine	93-106	prostaglandin E receptor 3 (subtype EP3)	Mus musculus	28-31
7890118-3	1994	The calmodulin dependent synaptic vesicle protein phosphorylation was enhanced following in vivo and in vitro lead exposure resulting in the depletion of the neurotransmitters norepinephrine and acetylcholine.	Norepinephrine	176-190	calmodulin 1	Rattus norvegicus	4-14
6381693-6	1984	In marked contrast, alpha-methyl substitution of epinephrine, norepinephrine and dopamine was associated with consistent and dramatic increases in potency for beta-2 adrenoceptor-mediated vasodepressor activity.	Norepinephrine	62-76	adrenoceptor beta 2	Rattus norvegicus	159-178
6380618-1	1984	Investigation of the effects of injecting monoamines (noradrenaline, dopamine and serotonin) into the third ventricle of the brain on the LH-RH content in the synaptosomal fraction of the mediobasal hypothalamus in intact and castrated male rats has demonstrated that all the three monoamines are involved in the regulation of synthesis and secretion of LH-RH and that their effects on LH-RH-producing neurons are steroid-dependent.	Norepinephrine	54-67	gonadotropin releasing hormone 1	Rattus norvegicus	138-143
6539879-4	1984	Correction of CSF MHPG levels for the contribution from plasma free MHPG provides an index of central norepinephrine metabolism.	Norepinephrine	102-116	colony stimulating factor 2	Homo sapiens	14-17
6732851-2	1984	However, alongside this effect, carbon disulphide produces a gradual increase in the adrenal content of dopamine-beta-hydroxylase indicated by the increase of in vitro estimated enzyme activity and by the increased in vivo conversion of dopamine to noradrenaline observed 24 hr after the ninth exposure.	Norepinephrine	249-262	dopamine beta-hydroxylase	Rattus norvegicus	104-129
6375731-12	1984	The reciprocal changes in lipase activities occurring during norepinephrine perfusion were hampered by colchicine and propranolol, pointing towards beta-receptor and microtubular mediation of tissue lipase processing and endothelial binding.	Norepinephrine	61-75	lipase G, endothelial type	Rattus norvegicus	26-32
6375731-12	1984	The reciprocal changes in lipase activities occurring during norepinephrine perfusion were hampered by colchicine and propranolol, pointing towards beta-receptor and microtubular mediation of tissue lipase processing and endothelial binding.	Norepinephrine	61-75	lipase G, endothelial type	Rattus norvegicus	199-205
6431755-4	1984	After administration of DL-threo-DOPS, the CSF level of 3-methoxy-4-hydroxyphenylglycol (MHPG), a major metabolite of norepinephrine, was 127.5% of the pretreatment level.	Norepinephrine	118-132	colony stimulating factor 2	Homo sapiens	43-46
6146989-7	1984	This theory was further supported by the finding that reduction of endogenous norepinephrine levels, via administration of the dopamine-beta-hydroxylase inhibitor FLA-63, markedly reduced the turning evoked by MK-801 and to a lesser degree that produced by amphetamine.	Norepinephrine	78-92	dopamine beta-hydroxylase	Rattus norvegicus	127-152
6722174-1	1984	Dopamine beta-hydroxylase (3,4- dihydroxyphenylethylamine ,ascorbate:oxygen oxidoreductase (beta-hydroxylating), EC 1.14.17.1) is the terminal enzyme in the biosynthetic pathway of norepinephrine.	Norepinephrine	181-195	dopamine beta-hydroxylase	Homo sapiens	0-25
6203542-7	1984	They differ from several in vitro studies which indicate a primary role of MAO-A in the metabolism of serotonin and of MAO-B in norepinephrine degradation in primate brain.	Norepinephrine	128-142	monoamine oxidase B	Macaca mulatta	119-124
6707645-6	1984	This divergence of the noradrenaline content appears to be related to differing levels of dopamine beta-monooxygenase activity.	Norepinephrine	23-36	dopamine beta-hydroxylase	Rattus norvegicus	90-117
7878073-9	1994	TH mRNA and TH activity in the adrenal glands were increased in the 3 cold-treated groups and these measures were correlated directly and significantly with plasma norepinephrine and epinephrine concentrations.	Norepinephrine	164-178	tyrosine hydroxylase	Rattus norvegicus	0-2
6200615-9	1984	Contractions evoked by transmural electric field stimulation or pharmacologically with carbachol, noradrenaline, substance P and prostaglandin F2 alpha were equally reduced by VIP 10(-7) mol.	Norepinephrine	98-111	vasoactive intestinal peptide	Sus scrofa	176-179
7933396-8	1994	Although oxygen delivery and oxygen consumption increased in both groups of patients, the pHi increased significantly in those patients treated with norepinephrine whereas the pHi decreased significantly in those patients receiving dopamine (P &lt; .001, for corrected 3-hour value).	Norepinephrine	149-163	glucose-6-phosphate isomerase	Homo sapiens	90-93
6200802-2	1984	In 25 patients with Korsakoff"s disease, we found that CSF levels of metabolites of norepinephrine, dopamine, and serotonin were significantly lower than in controls.	Norepinephrine	84-98	colony stimulating factor 2	Homo sapiens	55-58
7958425-7	1994	Dibutyryl cyclic AMP further enhanced levels of AP-2 transcripts in both P19 astrocytes and primary astrocytes which also respond to agents elevating intracellular cAMP (noradrenaline, isoproterenol, forskolin).	Norepinephrine	170-183	transcription factor AP-2, alpha	Mus musculus	48-52
6145128-0	1984	Luteinizing hormone-releasing hormone increases dopamine turnover in the lateral palisade zone of the median eminence and reduces noradrenaline turnover in the nuc.	Norepinephrine	130-143	gonadotropin releasing hormone 1	Rattus norvegicus	0-37
6145128-3	1984	LH-RH highly selectively increases dopamine (DA) turnover in the lateral palisade zone of the median eminence and highly selectively reduces noradrenaline turnover in the nucleus preopticus medialis without influencing amine levels in these CA nerve terminal systems.	Norepinephrine	141-154	gonadotropin releasing hormone 1	Rattus norvegicus	0-5
6145128-4	1984	It is suggested that the ultrashort feed-back action of LH-RH involves increased release of DA in the lateral palisade zone leading to activation of the DA receptor inhibiting LH-RH release as well as a reduced noradrenaline release in the nucleus preopticus medialis leading to a reduced excitatory influence on the LH-RH neurons at the soma-dendritic level.	Norepinephrine	211-224	gonadotropin releasing hormone 1	Rattus norvegicus	56-61
7532621-6	1994	NGF secretion was induced by catecholaminergic compounds in the following order isoproterenol &gt; epinephrine = norepinephrine &gt;&gt; dopamine.	Norepinephrine	113-127	nerve growth factor	Rattus norvegicus	0-3
6200083-5	1984	The CSF level of norepinephrine (NE) in underweight anorectics and in these patients a few weeks after weight restoration was similar to that in normal subjects.	Norepinephrine	17-31	colony stimulating factor 2	Homo sapiens	4-7
7845598-9	1994	In the pineal, a similar, although not identical, pattern of activator protein-1 activation has also been demonstrated in cultured glands following treatment with norepinephrine.	Norepinephrine	163-177	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	61-80
6426473-1	1984	The adrenergic amines noradrenaline and adrenaline increased flux through phenylalanine hydroxylase by approx.	Norepinephrine	22-35	phenylalanine hydroxylase	Rattus norvegicus	74-99
7813590-6	1994	In the norepinephrine-stimulated aorta, endothelium-dependent relaxation induced by endothelin-3 was antagonized by 0.3-10 microM RES-701-1 in a concentration-dependent manner.	Norepinephrine	7-21	endothelin 3	Rattus norvegicus	84-96
7813592-3	1994	The angiotensin AT1 receptor antagonist, DUP753 (losartan), not only blocked this action but also decreased the IC50 value of l-noradrenaline.	Norepinephrine	126-141	angiotensin II receptor, type 1a	Rattus norvegicus	16-19
6368205-0	1984	Neuropeptide tyrosine (NPY) immunoreactivity in norepinephrine-containing cells and nerves of the mammalian adrenal gland.	Norepinephrine	48-62	neuropeptide Y	Homo sapiens	0-27
6368205-1	1984	The application of immunocytochemistry at both light and electron microscopic levels has revealed neuropeptide tyrosine (NPY)-immunoreactive material to be localized to norepinephrine-containing endocrine cells in the adrenal medulla and also to varicose nerve fibers penetrating the adrenal cortex of several mammalian species, including horse, cat, rat, guinea pig and mouse.	Norepinephrine	169-183	neuropeptide Y	Homo sapiens	98-119
7835624-13	1994	These COMT inhibitors also decrease the amount of COMT dependent metabolites of adrenaline and noradrenaline in plasma.	Norepinephrine	95-108	catechol-O-methyltransferase	Homo sapiens	6-10
7835624-13	1994	These COMT inhibitors also decrease the amount of COMT dependent metabolites of adrenaline and noradrenaline in plasma.	Norepinephrine	95-108	catechol-O-methyltransferase	Homo sapiens	50-54
6368205-1	1984	The application of immunocytochemistry at both light and electron microscopic levels has revealed neuropeptide tyrosine (NPY)-immunoreactive material to be localized to norepinephrine-containing endocrine cells in the adrenal medulla and also to varicose nerve fibers penetrating the adrenal cortex of several mammalian species, including horse, cat, rat, guinea pig and mouse.	Norepinephrine	169-183	neuropeptide Y	Homo sapiens	121-124
6368205-2	1984	Correlative electron microscopic immunostaining has revealed that enkephalin and NPY immunoreactivities are co-localized to the same norepinephrine-containing secretory granules.	Norepinephrine	133-147	neuropeptide Y	Homo sapiens	81-84
6321662-5	1984	Noradrenaline induced serotonin N-acetyltransferase activity with either atmosphere.	Norepinephrine	0-13	aralkylamine N-acetyltransferase	Rattus norvegicus	22-51
6379758-0	1984	Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibers.	Norepinephrine	46-59	neuropeptide Y	Oryctolagus cuniculus	0-14
6379758-2	1984	NPY probably co-exists with noradrenaline in such fibers since chemical or surgical sympathectomy eliminated both NPY and noradrenaline from perivascular nerve fibers and since double staining demonstrated dopamine-beta-hydroxylase, the enzyme that catalyzes the conversion of dopamine to noradrenaline, and NPY in the same perivascular nerve fibers.	Norepinephrine	28-41	neuropeptide Y	Oryctolagus cuniculus	114-117
6379758-2	1984	NPY probably co-exists with noradrenaline in such fibers since chemical or surgical sympathectomy eliminated both NPY and noradrenaline from perivascular nerve fibers and since double staining demonstrated dopamine-beta-hydroxylase, the enzyme that catalyzes the conversion of dopamine to noradrenaline, and NPY in the same perivascular nerve fibers.	Norepinephrine	28-41	neuropeptide Y	Oryctolagus cuniculus	114-117
6379758-2	1984	NPY probably co-exists with noradrenaline in such fibers since chemical or surgical sympathectomy eliminated both NPY and noradrenaline from perivascular nerve fibers and since double staining demonstrated dopamine-beta-hydroxylase, the enzyme that catalyzes the conversion of dopamine to noradrenaline, and NPY in the same perivascular nerve fibers.	Norepinephrine	122-135	neuropeptide Y	Oryctolagus cuniculus	0-3
6379758-2	1984	NPY probably co-exists with noradrenaline in such fibers since chemical or surgical sympathectomy eliminated both NPY and noradrenaline from perivascular nerve fibers and since double staining demonstrated dopamine-beta-hydroxylase, the enzyme that catalyzes the conversion of dopamine to noradrenaline, and NPY in the same perivascular nerve fibers.	Norepinephrine	122-135	neuropeptide Y	Oryctolagus cuniculus	0-3
6379758-4	1984	NPY greatly enhanced the adrenergically mediate contractile response to electrical stimulation and to application of adrenaline, noradrenaline or histamine, as studied in the isolated rabbit gastro-epiploic and femoral arteries.	Norepinephrine	129-142	neuropeptide Y	Oryctolagus cuniculus	0-3
6422033-7	1984	The results indicate that depletion of hypothalamic noradrenaline causes subtle changes in the endogenous release of LHRH and may alter the negative feedback effects of steroids on the hypothalamic-pituitary axis.	Norepinephrine	52-65	gonadotropin releasing hormone 1	Rattus norvegicus	117-121
6693899-0	1984	Glial fibrillary acidic protein: norepinephrine stimulated phosphorylation in intact C-6 glioma cells.	Norepinephrine	33-47	complement C6	Rattus norvegicus	85-88
6142395-7	1984	On the other hand, prazosine (alpha 1-type antagonist) blocked the stimulatory effect of epinephrine and norepinephrine on AC system.	Norepinephrine	105-119	adrenoceptor alpha 1D	Homo sapiens	30-37
6142395-8	1984	Similarly, the alpha 2-agonist, clonidine, did not affect the catecholamines" stimulated AC activity while alpha 1 agonist, phenylephrine, induced an additive enhancement of norepinephrine production of cAMP.	Norepinephrine	174-188	adrenoceptor alpha 1D	Homo sapiens	107-114
6697736-1	1984	Sympathetic nervous system (SNS) activity and circulating norepinephrine (NE) levels may play roles in the elevated pulmonary vascular resistance (PVR) found in patients with pulmonary hypertension.	Norepinephrine	58-72	PVR cell adhesion molecule	Homo sapiens	147-150
8068027-0	1994	Stabilization of the mRNA for the uncoupling protein thermogenin by transcriptional/translational blockade and by noradrenaline in brown adipocytes differentiated in culture: a degradation factor induced by cessation of stimulation?	Norepinephrine	114-127	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	53-64
8068027-2	1994	After 7 days in culture, the cells were stimulated for 24 h with noradrenaline, and a high level of thermogenin mRNA was then observed.	Norepinephrine	65-78	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	100-111
8068027-4	1994	The presence of noradrenaline during transcriptional blockade led to a further stabilization of thermogenin mRNA.	Norepinephrine	16-29	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	96-107
6713511-5	1984	Of these the adrenaline and small-granule chromaffin (SGC) cells were more affected by morphine than noradrenaline cells.	Norepinephrine	101-114	serglycin	Mus musculus	54-57
7954594-10	1994	The alpha 1a adrenergic receptor subtype antagonist WB 4101 abolished noradrenaline stimulated inositol phosphate generation in myocytes, whereas chlorethylclonidine at large doses only partially inhibited this response.	Norepinephrine	70-83	adrenoceptor alpha 1D	Rattus norvegicus	4-32
6320030-2	1984	Blockade of norepinephrine synthesis by the injection of the dopamine beta-hydroxylase inhibitors, diethyldithiocarbamate or fusaric acid, prevented the inhibition of LH release, whereas blockade of epinephrine synthesis by injecting the phenylethanolamine N-methyltransferase inhibitor, 2,3-dichloro-methylbenzylamine, had no effect.	Norepinephrine	12-26	phenylethanolamine-N-methyltransferase	Rattus norvegicus	238-276
8197200-3	1994	dSERT displays highest overall amino acid sequence identity with the mammalian 5HT (51%), norepinephrine (47%), and dopamine (47%) transporters and shares with all transporters 104 absolutely conserved amino acid residues.	Norepinephrine	90-104	Serotonin transporter	Drosophila melanogaster	0-5
8065515-1	1994	Aromatic 1-amino acid decarboxylase (AADC) is involved in the synthesis of the putative neurotransmitters dopamine (DA), norepinephrine (NA) and 5-hydroxytryptamine (5-HT).	Norepinephrine	121-135	dopa decarboxylase	Rattus norvegicus	37-41
6661240-0	1983	Leucine enkephalin antagonizes norepinephrine-induced 45Ca++ accumulation in rat atria.	Norepinephrine	31-45	proenkephalin	Rattus norvegicus	8-18
6417135-2	1983	The 20,000-dalton light chain of myosin was maximally phosphorylated in the stretched noncontracting muscles, equal to that in the nonstretched contracting muscles challenged with K+ or norepinephrine.	Norepinephrine	186-200	myosin heavy chain 14	Homo sapiens	33-39
7518332-3	1994	IL-1 induced the broadest range of neurochemical changes, affecting central norepinephrine (NE), serotonin (5-HT) and dopamine (DA) activity.	Norepinephrine	76-90	interleukin 1 complex	Mus musculus	0-4
8138589-6	1994	The data suggest a) that PGE2 and PGF2 alpha facilitate and synergize with, rather than mediate, the actions of EGF in hepatocytes, and b) that this effect of the PGs occurs by mechanisms that are at least partly distinct from those of norepinephrine.	Norepinephrine	236-250	epidermal growth factor like 1	Rattus norvegicus	112-115
7912402-4	1994	COS cell hSVMT expression yielded nanomolar affinities for tetrabenazine and reserpine, micromolar affinities for haloperidol, GBR12909, serotonin, mazindol, nomifensin and d-amphetamine, while dopamine, epinephrine, norepinephrine and histamine each displayed millimolar affinities.	Norepinephrine	217-231	solute carrier family 18 member A2	Homo sapiens	9-14
6197036-6	1983	Variables that contribute much of the variability of norepinephrine and major monoamine metabolite concentrations in drug-free CSF samples from schizophrenic patients remain unknown and cannot be controlled.	Norepinephrine	53-67	colony stimulating factor 2	Homo sapiens	127-130
6640654-4	1983	Noradrenaline constricted these vessels in a concentration-dependent manner, the response being altered by phentolamine 10(-8) M to 10(-6) M. There was no statistically significant difference between migraine patients and controls with respect to maximal contractile force (Emax) or pD2 (negative logarithm of the concentration eliciting half maximal force).	Norepinephrine	0-13	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	283-286
6140096-3	1983	Norepinephrine appears to inhibit hypothalamic corticotropin-releasing factor, thus decreasing ACTH secretion by the pituitary and, in turn, cortisol secretion by the adrenal glands.	Norepinephrine	0-14	corticotropin releasing hormone	Homo sapiens	47-77
6195528-7	1983	We demonstrate that the increase in intracellular cyclic AMP induced by noradrenaline is markedly enhanced by somatostatin and substance P and is inhibited by enkephalin, even though these peptides on their own have little or no effect on the basal levels of cyclic AMP.	Norepinephrine	72-85	proenkephalin	Rattus norvegicus	159-169
6352871-5	1983	Addition of insulin to chromaffin cell cultures produced a doubling of cellular protein and opioid peptide levels by 6 days and produced a concentration-dependent increase in the dopamine and norepinephrine contents of the cells with only a slight elevation in cell epinephrine.	Norepinephrine	192-206	insulin	Bos taurus	12-19
6228322-0	1983	[Noradrenaline level in the CSF and plasma of patients with acute cerebral vascular diseases].	Norepinephrine	1-14	colony stimulating factor 2	Homo sapiens	28-31
6600810-2	1983	ANA negative patients were shown to have significantly higher levels of cortisol during a cold challenge than either ANA positive patients or normal controls, and exhibited significantly lower levels of plasma norepinephrine compared with normal controls.	Norepinephrine	210-224	BTG anti-proliferation factor 3	Homo sapiens	0-3
7984279-1	1994	Here we have studied the effect of various 5-HT1A and 5-HT2 receptor-selective drugs on noradrenaline release in the hippocampus on anaesthetized and awake rats using microdialysis.	Norepinephrine	88-101	5-hydroxytryptamine receptor 1A	Rattus norvegicus	43-49
7984279-2	1994	In the anaesthetized rat, administration of the 5-HT1A agonists buspirone, gepirone and ipsapirone increased noradrenaline levels in the microdialysates.	Norepinephrine	109-122	5-hydroxytryptamine receptor 1A	Rattus norvegicus	48-54
6196036-6	1983	[D-Pro2]p-SP and [pGlu5, Gly7]-SP5-11 were active in the dopamine-rich areas, but inactive in the noradrenaline (norepinephrine)-predominant parts of the brain.	Norepinephrine	98-111	Sp9 transcription factor	Rattus norvegicus	31-37
8302852-3	1994	Sequence analysis indicates 12 putative transmembrane domains and strong homologies (approximately 50%) among dSERT1 and mammalian 5HT, norepinephrine, and dopamine transporters.	Norepinephrine	136-150	Serotonin transporter	Drosophila melanogaster	110-116
6196036-6	1983	[D-Pro2]p-SP and [pGlu5, Gly7]-SP5-11 were active in the dopamine-rich areas, but inactive in the noradrenaline (norepinephrine)-predominant parts of the brain.	Norepinephrine	113-127	Sp9 transcription factor	Rattus norvegicus	31-37
6653697-6	1983	Measurements of catecholamine turnover rates in the MPO/AH and in the mediobasal hypothalamus (MBH) yielded reduced preoptic but unchanged hypothalamic norepinephrine (NE) and stimulated hypothalamic dopamine (DA) turnover.	Norepinephrine	152-166	myeloperoxidase	Rattus norvegicus	52-55
7862266-3	1994	All TRH doses studied enhanced blood pressure and noradrenaline and adrenaline secretion.	Norepinephrine	50-63	thyrotropin releasing hormone	Rattus norvegicus	4-7
7104386-5	1982	Glucagon, epinephrine, norepinephrine, isoproterenol and phenylephrine each increases significantly glycogen phosphorylase a activity and decreases significantly the pyruvate kinase activity ratio (assayed with 0.8 mM phosphoenolpyruvate +/- 200 microM fructose 1,6-bisphosphate) in hepatocytes from both juvenile and adult rabbits.	Norepinephrine	23-37	pyruvate kinase PKLR	Oryctolagus cuniculus	166-181
8267197-1	1993	BACKGROUND: Previous work has established that 2-chloroprocaine epidural anesthesia has no effect on circulating plasma epinephrine concentrations in young, healthy, resting volunteers, and results in a decrease in norepinephrine concentration only when a level of analgesia to pinprick of C-8 is reached.	Norepinephrine	215-229	homeobox C8	Homo sapiens	290-293
8258340-8	1993	In line with the lower affinity for beta 2-adrenergic receptors, norepinephrine was less effective than EPI in inducing detachment of NK cells from EC.	Norepinephrine	65-79	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	36-42
6289135-3	1982	The endogenous levels of noradrenaline were similar in the cerebral cortex of the Quaking mice and their corresponding controls, while a significant increase of endogenous noradrenaline was found in the brain stem of the mutants.	Norepinephrine	25-38	quaking, KH domain containing RNA binding	Mus musculus	82-89
8216383-3	1993	The procedure is suitable for use with a wide range of MAO substrates, although 5-hydroxytryptamine, adrenaline and noradrenaline are too readily oxidized by hydrogen peroxide to be used.	Norepinephrine	116-129	monoamine oxidase A	Rattus norvegicus	55-58
7104421-0	1982	Increased noradrenaline levels in CSF and plasma of schizophrenic patients.	Norepinephrine	10-23	colony stimulating factor 2	Homo sapiens	34-37
6804217-0	1982	Alterations in the responsiveness of median eminence luteinizing hormone-releasing hormone nerve terminals to norepinephrine and prostaglandin E2 in vitro during the rat estrous cycle.	Norepinephrine	110-124	gonadotropin releasing hormone 1	Rattus norvegicus	53-90
7694764-1	1993	The purpose of the present study was to identify the sites of origin of the noradrenergic fibers that project to areas containing gonadotropin-releasing hormone (GnRH) perikarya since norepinephrine (NE) is known to influence the activity of GnRH neurons.	Norepinephrine	184-198	gonadotropin releasing hormone 1	Homo sapiens	130-160
7694764-1	1993	The purpose of the present study was to identify the sites of origin of the noradrenergic fibers that project to areas containing gonadotropin-releasing hormone (GnRH) perikarya since norepinephrine (NE) is known to influence the activity of GnRH neurons.	Norepinephrine	184-198	gonadotropin releasing hormone 1	Homo sapiens	162-166
7068205-6	1982	Unlike the normal adrenal, P259 in NEDH rats contains mainly norepinephrine and dopamine with little epinephrine; it appears that P259 is deficient in the enzyme phenylethanolamine-N-methyltransferase (PNMT), which converts norepinephrine to epinephrine.	Norepinephrine	224-238	phenylethanolamine-N-methyltransferase	Rattus norvegicus	162-200
7694764-1	1993	The purpose of the present study was to identify the sites of origin of the noradrenergic fibers that project to areas containing gonadotropin-releasing hormone (GnRH) perikarya since norepinephrine (NE) is known to influence the activity of GnRH neurons.	Norepinephrine	184-198	gonadotropin releasing hormone 1	Homo sapiens	242-246
7098494-7	1982	This result suggests that acetyl coenzyme A may play an important role in the norepinephrine-induced induction of serotonin N-acetyltransferase.	Norepinephrine	78-92	aralkylamine N-acetyltransferase	Rattus norvegicus	114-143
7061654-1	1982	This paper describes a new and highly sensitive assay for phenylethanolamine N-methyltransferase (PNMT) activity with noradrenaline as substrate in various rat brain regions by high-performance liquid chromatography with electrochemical detection.	Norepinephrine	118-131	phenylethanolamine-N-methyltransferase	Rattus norvegicus	58-96
8333512-7	1993	In hypothyroid rats with hemidenervation of BAT, norepinephrine (NE) modestly increased ME and G-6-PDH activities in the denervated side, with little or no effect in the intact side.	Norepinephrine	49-63	glucose-6-phosphate dehydrogenase	Rattus norvegicus	95-102
8330200-1	1993	Monoamine oxidase A and B (MAO A and B; EC 1.4.3.4) are integral proteins of the outer mitochondrial membrane that degrade monoamines including the neurotransmitters norepinephrine, dopamine, and serotonin.	Norepinephrine	166-180	monoamine oxidase A	Rattus norvegicus	0-25
8330200-1	1993	Monoamine oxidase A and B (MAO A and B; EC 1.4.3.4) are integral proteins of the outer mitochondrial membrane that degrade monoamines including the neurotransmitters norepinephrine, dopamine, and serotonin.	Norepinephrine	166-180	monoamine oxidase A	Rattus norvegicus	27-38
8391652-11	1993	The results indicate that cerebrocortical noradrenaline release increases gradually during chronic MAO inhibition.	Norepinephrine	42-55	monoamine oxidase A	Rattus norvegicus	99-102
8097683-0	1993	Noradrenaline kinetics and coronary haemodynamics during acute beta 1-adrenoceptor blockade in man.	Norepinephrine	0-13	adrenoceptor beta 1	Homo sapiens	63-82
8097243-5	1993	The influence of prolonged in vivo exposure to norepinephrine on the beta adrenoceptor-mediated lipolytic responses was investigated in both species.	Norepinephrine	47-61	beta-3 adrenergic receptor	Cavia porcellus	74-86
7061654-1	1982	This paper describes a new and highly sensitive assay for phenylethanolamine N-methyltransferase (PNMT) activity with noradrenaline as substrate in various rat brain regions by high-performance liquid chromatography with electrochemical detection.	Norepinephrine	118-131	phenylethanolamine-N-methyltransferase	Rattus norvegicus	98-102
7066709-4	1982	Our results, in both randomly sampled and serially sectioned material, unequivocally establish the presence of AChE in all pontomedullary cell groups emitting catecholamine fluorescence, the majority of which are known to consist of noradrenaline perikarya.	Norepinephrine	233-246	acetylcholinesterase	Rattus norvegicus	111-115
8440378-5	1993	Preconfluent cells in brown fat primary cultures responded to norepinephrine with a decrease in C/EBP alpha and an increase in C/EBP beta mRNA; in confluent cells the expression of both factors was increased.	Norepinephrine	62-76	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	96-107
7066709-5	1982	Hence in contrast to previous reports the occurrence of AChE in central noradrenaline neurons appears to be generalized.	Norepinephrine	72-85	acetylcholinesterase	Rattus norvegicus	56-60
6976501-1	1982	Corticotropin-releasing factor administered intracerebroventricularly produces prolonged elevation of plasma concentration of epinephrine, norepinephrine and glucose.	Norepinephrine	139-153	corticotropin releasing hormone	Homo sapiens	0-30
8458902-2	1993	This assay requires a partially purified PNMT preparation derived from bovine adrenals, with noradrenaline and S-adenosyl-L-methionine (SAM) as co-substrates.	Norepinephrine	93-106	phenylethanolamine N-methyltransferase	Bos taurus	41-45
8382265-5	1993	FTX or nitrendipine reduced adrenaline and noradrenaline release by approximately 80 and 70%, respectively, but both substances together abolished the K(+)-evoked catecholamine release, as measured by HPLC.	Norepinephrine	43-56	FTX transcript, XIST regulator	Homo sapiens	0-3
7058671-6	1982	From the findings described here it may be concluded that 2-hydroxyoestradiol-17 beta, as previously shown in vitro, also affects the metabolism of noradrenaline in vivo by directly interacting with the catechol-O-methyltransferase.	Norepinephrine	148-161	catechol-O-methyltransferase	Rattus norvegicus	203-231
7162634-8	1982	However, pretreatment of the rabbits with monofluoromethyldopa, an irreversible inhibitor of DOPA decarboxylase, transformed the biexponential decline of noradrenaline overflow into a monoexponential one with the same rate constant as that of dopamine beta-hydroxylase overflow.	Norepinephrine	154-167	aromatic-L-amino-acid decarboxylase	Oryctolagus cuniculus	93-111
6117605-8	1981	In vitro studies showed that the spontaneous outflow of noradrenaline from hypothalamic slices was accelerated by GYKI 11679 in a dose-dependent manner in a concentration range of 10(-5) to 10(-7) M. In a 10-fold higher range, GYKI 11679 produced inhibition of both the hypothalamic and the adrenal tyrosine hydroxylase activity but did not alter DOPA-decarboxylase, dopamine-beta-hydroxylase, or monoamine oxidase activities.	Norepinephrine	56-69	dopamine beta-hydroxylase	Rattus norvegicus	367-392
7258379-0	1981	The effect of pimozide on CSF norepinephrine in schizophrenia.	Norepinephrine	30-44	colony stimulating factor 2	Homo sapiens	26-29
7272380-2	1981	The inhibitory effect of the neurotransmitter norepinephrine (NE) on the hypothalamic-pituitary adrenal (HPA) axis through the regulation of corticotropin-releasing factor has been suggested by animal in vitro studies.	Norepinephrine	46-60	corticotropin releasing hormone	Homo sapiens	141-171
7464918-5	1981	Recent studies with antiserum to dopamine-beta-hydroxylase (DBH), the enzyme that converts dopamine to noradrenaline, provided evidence for the existence of noradrenergic cells.	Norepinephrine	103-116	dopamine beta-hydroxylase	Rattus norvegicus	33-58
7464918-8	1981	We report here the simultaneous localization, in the same histological section, of 3H-oestradiol and the enzyme dopamine-beta-hydroxylase in neurones of the rat lower brain stem with a combined technique of thaw-mount autoradiography and immunohistochemistry, demonstrating that noradrenaline- or adrenaline-containing neurones are oestradiol target cells.	Norepinephrine	279-292	dopamine beta-hydroxylase	Rattus norvegicus	112-137
6261951-2	1981	Norepinephrine (NE) and dibutyryl cyclic 3",5"-adenosine monophosphate (dBcAMP) treatment of cells that had been in culture for 5 and 21 days produced a stimulation in the enzyme activity of serotonin N-acetyl transferase, an enzyme important in indole synthesis.	Norepinephrine	0-14	aralkylamine N-acetyltransferase	Rattus norvegicus	191-221
6250208-2	1980	The beta adrenoreceptor mediated desensitization of the hyperpolarization response to norepinephrine observed in pinealocyte membranes was rapidly reversed following the infusion of dopamine-beta-hydroxylase (DBH).	Norepinephrine	86-100	dopamine beta-hydroxylase	Rattus norvegicus	182-207
6250208-2	1980	The beta adrenoreceptor mediated desensitization of the hyperpolarization response to norepinephrine observed in pinealocyte membranes was rapidly reversed following the infusion of dopamine-beta-hydroxylase (DBH).	Norepinephrine	86-100	dopamine beta-hydroxylase	Rattus norvegicus	209-212
6250208-4	1980	We suggest that the dissociation of the concentrations of norepinephrine and dopamine-beta-hydroxylase released into the synaptic cleft as a result of continuous sympathetic nerve stimulation produces a relative dopamine-beta-hydroxylase deficiency which is associated with the beta receptor desensitization.	Norepinephrine	58-72	dopamine beta-hydroxylase	Rattus norvegicus	212-237
6244905-3	1980	Helical strips of rat tail artery relax in response to potassium after norepinephrine-induced contractions in physiological salt solution containing a low-potassium concentration.	Norepinephrine	71-85	relaxin 1	Rattus norvegicus	34-39
1280829-4	1992	We have previously shown that norepinephrine mediates the release of luteinizing hormone-releasing hormone (LHRH) from LHRH terminals in the median eminence into the hypophyseal portal veins, which transport LHRH to the anterior pituitary gland to trigger release of luteinizing hormone from gonadotrophs.	Norepinephrine	30-44	gonadotropin releasing hormone 1	Homo sapiens	69-106
6155770-0	1980	Effects of the histamine H2-receptor agonists dimaprit and 4-methylhistamine on the central noradrenaline and serotonin system.	Norepinephrine	92-105	histamine receptor H 2	Rattus norvegicus	15-36
1280829-4	1992	We have previously shown that norepinephrine mediates the release of luteinizing hormone-releasing hormone (LHRH) from LHRH terminals in the median eminence into the hypophyseal portal veins, which transport LHRH to the anterior pituitary gland to trigger release of luteinizing hormone from gonadotrophs.	Norepinephrine	30-44	gonadotropin releasing hormone 1	Homo sapiens	108-112
1280829-4	1992	We have previously shown that norepinephrine mediates the release of luteinizing hormone-releasing hormone (LHRH) from LHRH terminals in the median eminence into the hypophyseal portal veins, which transport LHRH to the anterior pituitary gland to trigger release of luteinizing hormone from gonadotrophs.	Norepinephrine	30-44	gonadotropin releasing hormone 1	Homo sapiens	119-123
6160707-1	1980	The paper deals with a modulatory function of Substance P (SP) (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2) with bearing on nociperception, behaviour, and norepinephrine uptake.	Norepinephrine	159-173	tachykinin 1	Mus musculus	46-57
1280829-4	1992	We have previously shown that norepinephrine mediates the release of luteinizing hormone-releasing hormone (LHRH) from LHRH terminals in the median eminence into the hypophyseal portal veins, which transport LHRH to the anterior pituitary gland to trigger release of luteinizing hormone from gonadotrophs.	Norepinephrine	30-44	gonadotropin releasing hormone 1	Homo sapiens	119-123
1280829-19	1992	The indication that NO is essential to norepinephrine-induced release of PGE2 from hypothalamic fragments provides insight into the mechanism of LHRH release and the results open the possibility that the importance of NO to neuronal functions may be widespread in the nervous system.	Norepinephrine	39-53	gonadotropin releasing hormone 1	Homo sapiens	145-149
6160707-1	1980	The paper deals with a modulatory function of Substance P (SP) (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2) with bearing on nociperception, behaviour, and norepinephrine uptake.	Norepinephrine	159-173	tachykinin 1	Mus musculus	59-61
6160707-5	1980	SP was found to inhibit or stimulate norepinephrine uptake of hypothalamus preparations depending on the experimental conditions.	Norepinephrine	37-51	tachykinin 1	Mus musculus	0-2
6101345-3	1980	Adrenal dopamine-beta-hydroxylase was also inhibited by NLCAs [3"O-methylnorlaudanosolinecarboxylic acid (MNLCA) Kj = 1.2 x 10(-4) M] and NLCA is a competitive inhibitor of norepinephrine methylation by hepatic catechol-O-methyltransferase (NLCA Kj = 5.6 x 10(-5) M).	Norepinephrine	173-187	dopamine beta-hydroxylase	Rattus norvegicus	8-33
1443867-11	1992	In conclusion, norepinephrine release in the rat trachea is inhibited via prostaglandin receptors that have the pharmacologic characteristics of the EP3 subtype.	Norepinephrine	15-29	prostaglandin E receptor 3	Rattus norvegicus	149-152
571950-0	1979	The direct converstion of dopamine 3-O-sulfate to norepinephrine by dopamine-beta-hydroxylase.	Norepinephrine	50-64	dopamine beta-hydroxylase	Homo sapiens	68-93
1280233-4	1992	Norepinephrine (NE), an alpha-adrenergic agonist, had no effect on basal PRL secretion but abolished thyrotropin-releasing hormone (TRH)-induced PRL secretion in a dose-dependent manner (EC50 100 nM).	Norepinephrine	0-14	thyrotropin releasing hormone	Rattus norvegicus	101-130
1280233-4	1992	Norepinephrine (NE), an alpha-adrenergic agonist, had no effect on basal PRL secretion but abolished thyrotropin-releasing hormone (TRH)-induced PRL secretion in a dose-dependent manner (EC50 100 nM).	Norepinephrine	0-14	thyrotropin releasing hormone	Rattus norvegicus	132-135
367530-1	1979	Dopamine-beta-hydroxylase (DBH), the enzyme that converts dopamine to norepinephrine, has been localized in light and electron microscopic preparations of rat brain by an immunocytochemical method using a peroxidase--anti-peroxidase Fab complex.	Norepinephrine	70-84	dopamine beta-hydroxylase	Rattus norvegicus	0-25
1335355-7	1992	We conclude that even though neonatal treatment of normal Wistar rats with nerve growth factor for 2 weeks induced an elevation of the norepinephrine levels in several tissues at the end of the treatment period, it was not sufficient to produce hypertension and structural alterations in the blood vessels.	Norepinephrine	135-149	nerve growth factor	Rattus norvegicus	75-94
367530-1	1979	Dopamine-beta-hydroxylase (DBH), the enzyme that converts dopamine to norepinephrine, has been localized in light and electron microscopic preparations of rat brain by an immunocytochemical method using a peroxidase--anti-peroxidase Fab complex.	Norepinephrine	70-84	dopamine beta-hydroxylase	Rattus norvegicus	27-30
33344-2	1978	The high Km value for the brain PNMT has been assumed to be responsible for the low methylation ratio between norepinephrine and epinephrine in the CNS.	Norepinephrine	110-124	phenylethanolamine-N-methyltransferase	Rattus norvegicus	32-36
1358633-7	1992	In rats given noradrenaline, CGRP dose dependently decreased MAP, MCFP and increased HR.	Norepinephrine	14-27	calcitonin-related polypeptide alpha	Rattus norvegicus	29-33
29422-0	1978	Effect of norepinephrine synthesis inhibitors and a dopamine agonist on hypothalamic LH-RH serum gonadotrophin and prolactin levels in gonadal steroid treated rats.	Norepinephrine	10-24	gonadotropin releasing hormone 1	Rattus norvegicus	85-90
1603085-5	1992	Addition of 10(-7) M norepinephrine resulted in approximately a 30-fold induction of Ucp mRNA within 4 h. The induction by norepinephrine was independent of cell density and also independent of thyroid hormone and insulin during the first 5 days in culture.	Norepinephrine	21-35	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	85-88
1603085-5	1992	Addition of 10(-7) M norepinephrine resulted in approximately a 30-fold induction of Ucp mRNA within 4 h. The induction by norepinephrine was independent of cell density and also independent of thyroid hormone and insulin during the first 5 days in culture.	Norepinephrine	123-137	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	85-88
1603085-7	1992	In contrast to Ucp, the expression of Gdc-1, which encodes the cytoplasmic glycerol-3-phosphate dehydrogenase and which is also induced in brown fat by cold exposure, was repressed by norepinephrine and induced by the addition of insulin.	Norepinephrine	184-198	glycerol-3-phosphate dehydrogenase 1 (soluble)	Mus musculus	38-43
683787-5	1978	These results are consistent with the hypothesis that biochemically primitive neuroblastomas deficient in dopamine beta-hydroxylase are move virulent than their mature analogues which produce epinephrine, norepinephrine, and their metabolites.	Norepinephrine	205-219	dopamine beta-hydroxylase	Homo sapiens	106-131
81009-0	1978	Biosynthesis of noradrenaline in C1300 mouse neuroblastoma [proceedings].	Norepinephrine	16-29	Rho guanine nucleotide exchange factor (GEF) 16	Mus musculus	45-58
1349592-5	1992	These data suggest that an excess of norepinephrine is present in polycystic ovary syndrome and that the hypophyseal response to LH-RH administration is correlated with catecholamine, especially norepinephrine activity.	Norepinephrine	195-209	gonadotropin releasing hormone 1	Homo sapiens	129-134
1309447-8	1992	Decreased norepinephrine stores correlate weakly with beta 1-adrenergic receptor downregulation consistent with the hypothesis that norepinephrine depletion occurs in response to increased adrenergic drive.	Norepinephrine	10-24	adrenoceptor beta 1	Homo sapiens	54-80
1309447-8	1992	Decreased norepinephrine stores correlate weakly with beta 1-adrenergic receptor downregulation consistent with the hypothesis that norepinephrine depletion occurs in response to increased adrenergic drive.	Norepinephrine	132-146	adrenoceptor beta 1	Homo sapiens	54-80
24033-5	1978	A32390A inhibits dopamine-beta-hydroxylase reduces heart and adrenal norepinephrine levels, lowers blood pressure in hypertensive rats, and possesses antibiotic activity vs. Gram-positive bacteria and fungi, including Candida albicans.	Norepinephrine	69-83	dopamine beta-hydroxylase	Rattus norvegicus	17-42
1346623-0	1992	A biphasic effect of noradrenaline on renin release from rat juxtaglomerular cells in vitro is mediated by alpha 1- and beta-adrenoceptors.	Norepinephrine	21-34	renin	Rattus norvegicus	38-43
1346623-1	1992	The direct effect of noradrenaline on renin release from juxtaglomerular (JG) cells in vitro were investigated in a dynamic superfusion system of dispersed rat renal cortical cells.	Norepinephrine	21-34	renin	Rattus norvegicus	38-43
1346623-2	1992	At low concentrations (1-100 nmol/l), noradrenaline stimulated renin release in a dose-dependent manner, while at higher concentrations (0.1-1 mmol/l) it inhibited renin release.	Norepinephrine	38-51	renin	Rattus norvegicus	63-68
1346623-2	1992	At low concentrations (1-100 nmol/l), noradrenaline stimulated renin release in a dose-dependent manner, while at higher concentrations (0.1-1 mmol/l) it inhibited renin release.	Norepinephrine	38-51	renin	Rattus norvegicus	164-169
196232-2	1977	Mean CSF norepinephrine levels were significantly elevated by chronic cerebellar stimulation and significantly depressed after intermittent cerebral cortical stimulation.	Norepinephrine	9-23	colony stimulating factor 2	Homo sapiens	5-8
1346623-6	1992	These results indicate that low concentrations of noradrenaline directly stimulate renin release from JG cells by the activation of beta-adrenoceptors, while high concentrations of noradrenaline inhibit renin release by the activation of alpha 1-adrenoceptors.	Norepinephrine	50-63	renin	Rattus norvegicus	83-88
1346623-6	1992	These results indicate that low concentrations of noradrenaline directly stimulate renin release from JG cells by the activation of beta-adrenoceptors, while high concentrations of noradrenaline inhibit renin release by the activation of alpha 1-adrenoceptors.	Norepinephrine	181-194	renin	Rattus norvegicus	203-208
1313316-5	1992	The putative irreversible alpha 1B-adrenoceptor antagonist, chlorethylclonidine, inhibited the response to norepinephrine in aortae from all species, but to dramatically different degrees.	Norepinephrine	107-121	adrenoceptor alpha 1B	Rattus norvegicus	26-47
891046-2	1977	Dopamine-beta-hydroxylase (D beta H) activity was measured in sera from ten healthy male students after 2 and 3 days fasting which is associated with increased circulating noradrenaline.	Norepinephrine	172-185	dopamine beta-hydroxylase	Homo sapiens	0-25
321776-0	1977	Suppression of serum LH-RH and LH in rats by an inhibitor of norepinephrine synthesis.	Norepinephrine	61-75	gonadotropin releasing hormone 1	Rattus norvegicus	21-26
1928327-3	1991	Prior exposure to the calmodulin antagonists calmidazolium (3 and 10 microM) and W-7 (10 microM) inhibited contractions to PMA in the presence and absence of extracellular Ca2+, while contractions to norepinephrine and KCl remained relatively unaffected.	Norepinephrine	200-214	calmodulin 1	Rattus norvegicus	22-32
871531-4	1977	Contractions produced by exogenous norepinephrine or serotonin in a potassium-free bath were also made to relax by the addition of potassium.	Norepinephrine	35-49	neurogenin 3	Rattus norvegicus	106-111
1661185-10	1991	In addition, the presence of hCG stimulated (by 40%) norepinephrine-induced release during proestrus, but no changes were apparent during the other stages of the estrous cycle.	Norepinephrine	53-67	chorionic gonadotropin subunit beta 5	Homo sapiens	29-32
991816-7	1976	These results suggest that there is a causal relationship between the high levels of progesterone in the uterus and the reduced amount of norepinephrine transmitter in the adrenergic nerves in this organ, and that plasma progesterone concentration and the changing progesterone receptor levels regulate uterine progesterone concentration.	Norepinephrine	138-152	progesterone receptor	Oryctolagus cuniculus	265-286
988175-0	1976	Effect of dopamine-beta-hydroxylase inhibitors on blood pressure and cardiac norepinephrine levels in rats subjected to immobilization stress.	Norepinephrine	77-91	dopamine beta-hydroxylase	Rattus norvegicus	10-35
1686575-1	1991	In the present study, we investigated the effects of nerve growth factor (NGF) on norepinephrine (NE) release from peripheral sympathetic nerve endings of rat mesenteric artery.	Norepinephrine	82-96	nerve growth factor	Rattus norvegicus	53-72
988175-11	1976	The present data support the hypothesis that the hypotensive action of picolinic acid derivatives may be attributable to the decrease in sympathetic nerve norepinephrine release caused by dopamine-beta-hydroxylase inhibition.	Norepinephrine	155-169	dopamine beta-hydroxylase	Rattus norvegicus	188-213
1686575-1	1991	In the present study, we investigated the effects of nerve growth factor (NGF) on norepinephrine (NE) release from peripheral sympathetic nerve endings of rat mesenteric artery.	Norepinephrine	82-96	nerve growth factor	Rattus norvegicus	74-77
966380-1	1976	Dopamine-beta-hydroxylase (DBH), the enzyme responsible for the biosynthesis of norepinephrine from dopamine was assayed in the blood serum of 23 normal adults, 16 patients with congestive heart failure, 19 patients with asymptomatic ischemic heart disease, 4 patients with angina pectoris at rest, 15 patients with essential hypertension, 8 patients with essential hypotension, 5 patients with neurocirculatory asthenia, and 9 normal adults before and after the exercise test.	Norepinephrine	80-94	dopamine beta-hydroxylase	Homo sapiens	0-25
1686254-6	1991	Thus, the vasodilator effect of the 5-HT1A receptor agonists urapidil, 5-methyl-urapidil, ipsapirone, flesinoxan and 8-OH-DPAT in the noradrenaline-perfused rat kidney appears to be mediated by their concomitant alpha 1A-adrenoceptor blockade.	Norepinephrine	134-147	5-hydroxytryptamine receptor 1A	Rattus norvegicus	36-42
1686254-6	1991	Thus, the vasodilator effect of the 5-HT1A receptor agonists urapidil, 5-methyl-urapidil, ipsapirone, flesinoxan and 8-OH-DPAT in the noradrenaline-perfused rat kidney appears to be mediated by their concomitant alpha 1A-adrenoceptor blockade.	Norepinephrine	134-147	adrenoceptor alpha 1A	Rattus norvegicus	212-233
966380-1	1976	Dopamine-beta-hydroxylase (DBH), the enzyme responsible for the biosynthesis of norepinephrine from dopamine was assayed in the blood serum of 23 normal adults, 16 patients with congestive heart failure, 19 patients with asymptomatic ischemic heart disease, 4 patients with angina pectoris at rest, 15 patients with essential hypertension, 8 patients with essential hypotension, 5 patients with neurocirculatory asthenia, and 9 normal adults before and after the exercise test.	Norepinephrine	80-94	dopamine beta-hydroxylase	Homo sapiens	27-30
180004-1	1976	Phenylalanine hydroxylase in Reuber H4 hepatoma cell cultures can be rapidly inactivated by the addition of epinephrine, norepinephrine, dopamine, or 3,4-dihydroxyphenylalanine, in order of decreasing effectiveness, to the culture medium.	Norepinephrine	121-135	phenylalanine hydroxylase	Rattus norvegicus	0-25
1685524-0	1991	M3-muscarinic receptor mediates prejunctional inhibition of noradrenaline release and the relaxation in cat femoral artery.	Norepinephrine	60-73	cholinergic receptor muscarinic 3	Homo sapiens	0-22
1685558-7	1991	In the sinoatrial pacemaker (-)-adrenaline caused positive chronotropic effects through both beta 1AR and beta 2AR while (-)-noradrenaline does so predominantly through beta 1AR.	Norepinephrine	121-138	adrenoceptor beta 1	Homo sapiens	169-177
1685558-8	1991	During beta 1AR blockade (-)-adrenaline did cause the same maximum effects through beta 2AR as (-)-noradrenaline did through beta 1AR.	Norepinephrine	95-112	adrenoceptor beta 1	Homo sapiens	125-133
1653068-5	1991	Catecholamines inhibited this process with an order of potency: isoprenaline greater than adrenaline greater than noradrenaline indicating involvement of beta 2-adrenoceptors.	Norepinephrine	114-127	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	154-160
1652275-1	1991	Heart rate and force can be increased by noradrenaline and adrenaline through an interaction with both beta 1-adrenoceptors (beta 1AR) and beta 2-adrenoceptors (beta 2 AR).	Norepinephrine	41-54	adrenoceptor beta 1	Homo sapiens	103-123
1652275-1	1991	Heart rate and force can be increased by noradrenaline and adrenaline through an interaction with both beta 1-adrenoceptors (beta 1AR) and beta 2-adrenoceptors (beta 2 AR).	Norepinephrine	41-54	adrenoceptor beta 1	Homo sapiens	125-133
1851836-8	1991	Therefore, the inhibitory effects of ANF and cANF appear to be prejunctional, on the release of the neurotransmitters, norepinephrine and ATP, from the nerve terminal and not postjunctional on the smooth muscle.	Norepinephrine	119-133	natriuretic peptides A	Oryctolagus cuniculus	37-40
1671333-1	1991	A physiologic response such as mucin secretion from epithelial cells in vivo may be under the control of several endogenous substances such as acetylcholine, norepinephrine, and vasoactive intestinal peptide (VIP).	Norepinephrine	158-172	LOC100508689	Homo sapiens	31-36
6786-1	1976	SK&amp;F 64139 is a potent, reversible inhibitor of phenylethanolamine N-methyltransferase; its IC50 concentration in our standard assay system was 1 X 10(-7) M. Kinetically, the compound is a competitive inhibitor with respect to norepinephrine but is uncompetitive when S-adenosylmethionine is the variable substrate.	Norepinephrine	231-245	phenylethanolamine-N-methyltransferase	Rattus norvegicus	52-90
1819921-6	1991	Depending on the DG4 and glaucine doses used, the pressor effects of noradrenaline (NA) and nicotine (NIC) were moderately to strongly suppressed or completely inhibited.	Norepinephrine	69-82	desmoglein 3	Homo sapiens	17-20
1984000-2	1991	The contractions, induced by 10(-8)-10(-5) M norepinephrine, were significantly potentiated at low Mg2+ (0.8 mM v. the normal, 1.2 mM).	Norepinephrine	45-59	mucin 7, secreted	Homo sapiens	99-102
1817163-5	1991	Noradrenaline which has been taken up into Caki-1 cells by uptake2 is metabolized by the intracellular enzymes catechol-O-methyltransferase (COMT) and to a lesser extend by monoamineoxidase (MAO).	Norepinephrine	0-13	catechol-O-methyltransferase	Homo sapiens	111-139
1817163-5	1991	Noradrenaline which has been taken up into Caki-1 cells by uptake2 is metabolized by the intracellular enzymes catechol-O-methyltransferase (COMT) and to a lesser extend by monoamineoxidase (MAO).	Norepinephrine	0-13	catechol-O-methyltransferase	Homo sapiens	141-145
1845768-1	1991	The effect of norepinephrine (NE) on the production of tumor necrosis factor (TNF) by rat spleen macrophages was determined.	Norepinephrine	14-28	tumor necrosis factor-like	Rattus norvegicus	55-76
1845768-1	1991	The effect of norepinephrine (NE) on the production of tumor necrosis factor (TNF) by rat spleen macrophages was determined.	Norepinephrine	14-28	tumor necrosis factor-like	Rattus norvegicus	78-81
1978979-12	1990	The beneficial effects of xamoterol in patients with heart failure could be due to prevention of the detrimental effects of norepinephrine such as beta 1-adrenoceptor downregulation of an increase of Gi (inhibitory guanine-nucleotide binding protein).	Norepinephrine	124-138	adrenoceptor beta 1	Homo sapiens	147-166
2129867-5	1990	We propose that the DBH/NPY/NGF-R-positive adrenal medullary ganglion cells are sympathetic postganglionic neurons producing noradrenaline.	Norepinephrine	125-138	nerve growth factor receptor	Rattus norvegicus	28-33
1697859-2	1990	In these cells, it was possible by norepinephrine (NE) addition to induce specifically the expression of the UCP gene.	Norepinephrine	35-49	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	109-112
2113409-4	1990	administration of TRH (0.6 and 3 nmol) at the T8-10 vertebral level resulted in a dose-related increase in epinephrine (E), norepinephrine (NE), and glucose levels, which was suppressed by prior administration of the ganglionic blocker, hexamethonium (1.5 mg/100 g b.	Norepinephrine	124-138	thyrotropin releasing hormone	Rattus norvegicus	18-21
1971714-8	1990	The action of DDTC could be mediated by a reduction in GHRH due to reduced norepinephrine synthesis, by an increase in somatostatin release through a dopaminergic stimulus, or by a direct dopaminergic effect on somatotrophs.	Norepinephrine	75-89	somatoliberin	Macaca fascicularis	55-59
2201297-2	1990	In control animals, a loss of insulin receptor activity was found with cellular ageing and increased levels of norepinephrine, epinephrine and glycosylated hemoglobin.	Norepinephrine	111-125	insulin receptor	Rattus norvegicus	30-46
1980074-2	1990	Concomitantly, the M2-receptor-mediated negative inotropic effect of carbachol was reduced, while the beta 1-adrenoceptor-mediated positive inotropic effect of noradrenaline was not altered.	Norepinephrine	160-173	adrenoceptor beta 1	Homo sapiens	102-121
6261-4	1976	Placement of bilateral lesions in the ventral norepinephrine bundles resulted in a greater than an 85% fall in the dopamine-beta-hydroxylase activity of the median eminence, arcuate nucleus, and ventromedial nucleus, but had no effect on tyrosine hydroxylase activity measured in those same areas.	Norepinephrine	46-60	dopamine beta-hydroxylase	Rattus norvegicus	115-140
133361-4	1976	The maintenance of a sufficient level of active norepinephrine on beta-receptors, either by displacement of norepinephrine in the nerve endings by dopamine, or by the inhibition of norepinephrine reuptake by imipramine, thus slows down or prevents the decrease in serotonin N-acetyltransferase activity after exposure to light during the night.	Norepinephrine	48-62	aralkylamine N-acetyltransferase	Rattus norvegicus	264-293
2295700-5	1990	Inhibition of duodenal bicarbonate secretion induced by CGRP coincided with significant increases in plasma norepinephrine (NE) and vasopressin concentrations.	Norepinephrine	108-122	calcitonin-related polypeptide alpha	Rattus norvegicus	56-60
1192563-3	1975	The affinity of the adrenergic receptors for norepinephrine was determined by computing the dissociation constant of the norepinephrine-receptor complex (KDR).	Norepinephrine	45-59	kinase insert domain receptor	Rattus norvegicus	154-157
34921047-2	2022	In this brain region, noradrenaline activates Galphaq-coupled alpha1-adrenergic receptors (alpha1-AR), causing action potential firing and serotonin release.	Norepinephrine	22-35	adenosine A1 receptor	Mus musculus	91-100
34921047-3	2022	In vitro, electrical stimulation elicits vesicular noradrenaline release and subsequent activation of alpha1-AR to produce an excitatory postsynaptic current (alpha1-AR-EPSC).	Norepinephrine	51-64	adenosine A1 receptor	Mus musculus	102-111
34921047-3	2022	In vitro, electrical stimulation elicits vesicular noradrenaline release and subsequent activation of alpha1-AR to produce an excitatory postsynaptic current (alpha1-AR-EPSC).	Norepinephrine	51-64	adenosine A1 receptor	Mus musculus	159-168
34921047-6	2022	The amount of noradrenaline released influenced the amplitude of the alpha1-AR-EPSC without altering the time constant of decay suggesting that once released, extracellular noradrenaline was cleared efficiently.	Norepinephrine	14-27	adenosine A1 receptor	Mus musculus	69-78
34921047-6	2022	The amount of noradrenaline released influenced the amplitude of the alpha1-AR-EPSC without altering the time constant of decay suggesting that once released, extracellular noradrenaline was cleared efficiently.	Norepinephrine	173-186	adenosine A1 receptor	Mus musculus	69-78
34921047-7	2022	Reuptake of noradrenaline via noradrenaline transporters was a primary means of terminating the alpha1-AR-EPSC, with little evidence for extrasynaptic diffusion of noradrenaline unless transporter-dependent reuptake was impaired.	Norepinephrine	12-25	adenosine A1 receptor	Mus musculus	96-105
1209687-9	1975	The results suggest that exogenous progesterone administration during late pregnancy increases epinephrine stores by declining monoamine metabolism by MAO and COMT and increasing their synthesis by PNMT which is responsible for N-methylation of norepinephrine to epinephrine.	Norepinephrine	245-259	phenylethanolamine-N-methyltransferase	Rattus norvegicus	198-202
34921047-7	2022	Reuptake of noradrenaline via noradrenaline transporters was a primary means of terminating the alpha1-AR-EPSC, with little evidence for extrasynaptic diffusion of noradrenaline unless transporter-dependent reuptake was impaired.	Norepinephrine	30-43	adenosine A1 receptor	Mus musculus	96-105
34571056-6	2021	Furthermore, a decrease of the levels of the key enzyme (TH) and transporter (VMAT2) of norepinephrine was evident both by western blot analysis and immunofluorescence.	Norepinephrine	88-102	solute carrier family 18 member A2	Homo sapiens	78-83
1201504-2	1975	Mcp (1.0 muM) decreased the inhibitory effects of ATP, ADP, and adenosine on peristalsis induced in the isolated guinea-pig ileum by a constant increase in intraluminal pressure, did not affect inhibition due to theophylline ethylenediamine, whilst it potentiated inhibition of peristalsis due to noradrenaline.	Norepinephrine	297-310	membrane cofactor protein	Cavia porcellus	0-3
34554376-0	2021	rno-miR-128-3p promotes apoptosis in rat granulosa cells (GCs) induced by norepinephrine through Wilms tumor 1 (WT1).	Norepinephrine	74-88	WT1 transcription factor	Rattus norvegicus	112-115
1174970-11	1975	In contrast, and despite the fluorescence findings, the total norepinephrine content of weaver and staggerer cerebella is significantly reduced and concentrations are not significantly different from normal.	Norepinephrine	62-76	RAR-related orphan receptor alpha	Mus musculus	99-108
34419120-1	2021	BACKGROUND: Through venous contraction, norepinephrine (NE) increases stressed blood volume and mean systemic pressure (Pms) and exerts a "fluid-like" effect.	Norepinephrine	40-54	proline rich protein BstNI subfamily 1	Homo sapiens	120-123
34419120-3	2021	Indeed, norepinephrine may enhance the effects of volume expansion: because fluid dilutes into a more constricted, smaller, venous network, fluid may increase Pms to a larger extent at a higher than at a lower dose of NE.	Norepinephrine	8-22	proline rich protein BstNI subfamily 1	Homo sapiens	159-162
34419120-10	2021	The increase in Pms ( Pms) induced by PLR was 13 (9-19)% at the higher dose of norepinephrine and 11 (6-16)% at the lower dose (p < 0.0001).	Norepinephrine	79-93	proline rich protein BstNI subfamily 1	Homo sapiens	16-19
34419120-10	2021	The increase in Pms ( Pms) induced by PLR was 13 (9-19)% at the higher dose of norepinephrine and 11 (6-16)% at the lower dose (p < 0.0001).	Norepinephrine	79-93	proline rich protein BstNI subfamily 1	Homo sapiens	22-25
34419120-11	2021	Pms reached during PLR at the high dose of NE was higher than expected by the sum of Pms at baseline at low dose,  Pms induced by changing the norepinephrine dose and  Pms induced by PLR at low dose of NE (35.6 (11.2) mmHg vs. 33.6 (10.9) mmHg, respectively, p < 0.01).	Norepinephrine	143-157	proline rich protein BstNI subfamily 1	Homo sapiens	115-118
34419120-13	2021	CONCLUSIONS: Norepinephrine enhances the Pms increase induced by PLR.	Norepinephrine	13-27	proline rich protein BstNI subfamily 1	Homo sapiens	41-44
34004054-11	2021	Further analyses revealed that GCN2 activation in macrophages reduced the expression of monoamine oxidase A (MAOA), resulting in increased norepinephrine (NE) secretion from macrophages to adipocytes, and this resulted in enhanced WAT browning and lipolysis.	Norepinephrine	139-153	monoamine oxidase A	Mus musculus	88-107
34004054-11	2021	Further analyses revealed that GCN2 activation in macrophages reduced the expression of monoamine oxidase A (MAOA), resulting in increased norepinephrine (NE) secretion from macrophages to adipocytes, and this resulted in enhanced WAT browning and lipolysis.	Norepinephrine	139-153	monoamine oxidase A	Mus musculus	109-113
35504726-9	2022	Inhibition of hypothalamic AMPK prevented ML364 from increasing serum norepinephrine and blood glucose.	Norepinephrine	70-84	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	27-31
171652-2	1975	These include norepinephrine or isoproterenol, and prostaglandin E1 or adenosine, which stimulate ornithine decarboxylase activity in C6-BU-1 glioma and N115 neuroblastoma cells, respectively.	Norepinephrine	14-28	ornithine decarboxylase 1	Rattus norvegicus	98-121
1120928-1	1975	Dopamine-beta-hydroxylase (DBH), an enxyme catalyzing the final step in the synthesis of norepinephrine, is released with norepinephrine on stimulation of the sympathetic nervous system.	Norepinephrine	89-103	dopamine beta-hydroxylase	Homo sapiens	0-25
1120928-1	1975	Dopamine-beta-hydroxylase (DBH), an enxyme catalyzing the final step in the synthesis of norepinephrine, is released with norepinephrine on stimulation of the sympathetic nervous system.	Norepinephrine	89-103	dopamine beta-hydroxylase	Homo sapiens	27-30
1120928-1	1975	Dopamine-beta-hydroxylase (DBH), an enxyme catalyzing the final step in the synthesis of norepinephrine, is released with norepinephrine on stimulation of the sympathetic nervous system.	Norepinephrine	122-136	dopamine beta-hydroxylase	Homo sapiens	0-25
1120928-1	1975	Dopamine-beta-hydroxylase (DBH), an enxyme catalyzing the final step in the synthesis of norepinephrine, is released with norepinephrine on stimulation of the sympathetic nervous system.	Norepinephrine	122-136	dopamine beta-hydroxylase	Homo sapiens	27-30
1117422-1	1975	Endogenous norepinephrine (NE) content of cat spleen slices was markedly depleted by incubating them in a sodium-free solution for 2 hours at 37 degrees C. Dopamine beta-hydroxylase (DBH) activity was not changed by this treatment.	Norepinephrine	11-25	dopamine beta-hydroxylase	Homo sapiens	183-186
35563271-7	2022	In turn, plasma corticosterone and oxidation of brain ketodienes and conjugated trienes determined the dynamics of brain MAO-A activity, and MAO-A activity determined the dynamics of brain norepinephrine.	Norepinephrine	189-203	monoamine oxidase A	Rattus norvegicus	141-146
35327387-10	2022	CONCLUSION: We demonstrate signs of UCP1-dependent norepinephrine-induced thermogenesis connected with higher expression of DIO2, PPARGC1A, CEBPB and PRDM16 in retroperitoneal VAT of PPGL and its relations to circulating HDLc and triglycerides levels.	Norepinephrine	51-65	CCAAT enhancer binding protein beta	Homo sapiens	140-145
35327387-10	2022	CONCLUSION: We demonstrate signs of UCP1-dependent norepinephrine-induced thermogenesis connected with higher expression of DIO2, PPARGC1A, CEBPB and PRDM16 in retroperitoneal VAT of PPGL and its relations to circulating HDLc and triglycerides levels.	Norepinephrine	51-65	PR/SET domain 16	Homo sapiens	150-156
234804-1	1975	Systemic biochemical indexes of sympathetic nerve functionplasma catecholamine concentrations and serum dopamine-beta-hydroxylase activitywere correlated with regional indexesnorepinephrine concentration activities of norepinephrine biosynthetic enzymes in the vas deferensand with blood pressures and pulse rates of 57 men at the time of vasectomy.	Norepinephrine	175-189	dopamine beta-hydroxylase	Homo sapiens	104-129
4155067-8	1974	All treatments appear to activate tyrosine hydroxylase by causing an increase in its affinity for substrate and pteridine cofactor and by decreasing its affinity for the end-product inhibitor, norepinephrine.	Norepinephrine	193-207	tyrosine 3-monooxygenase	Cavia porcellus	34-54
4155067-9	1974	These results provide direct evidence that the enhanced formation of norepinephrine seen during stimulation of sympathetically innervated tissues arises from an activation of tyrosine hydroxylase.	Norepinephrine	69-83	tyrosine 3-monooxygenase	Cavia porcellus	175-195
4365377-1	1973	Depletion of neural norepinephrine by reserpine treatment or by denervation resulted in a greater induction of serotonin N-acetyltransferase (EC 2.3.1.5) and a higher elevation of cyclic AMP in postsynaptic pineal cell to small amount of isoproterenol.	Norepinephrine	20-34	aralkylamine N-acetyltransferase	Rattus norvegicus	111-140
4722575-0	1973	Release of dopamine from central noradrenaline and dopamine nerves induced by a dopamine-beta-hydroxylase inhibitor.	Norepinephrine	33-46	dopamine beta-hydroxylase	Homo sapiens	80-105
5085235-8	1972	Both AHR 602 and McN-A-343 facilitated the release of noradrenaline by SNS and inhibited that by DMPP.	Norepinephrine	54-67	aryl hydrocarbon receptor	Oryctolagus cuniculus	5-8
5085235-10	1972	The muscarinic compounds (except AHR 602 and McN-A-343) each produce atropine-sensitive inhibition of noradrenaline release evoked both by SNS and DMPP although it is likely that furtrethonium and pilocarpine have additional non-muscarinic inhibitory activity against DMPP.	Norepinephrine	102-115	aryl hydrocarbon receptor	Oryctolagus cuniculus	33-36
2576534-1	1989	Atrial natriuretic peptide (ANP) and sodium nitroprusside have potent vasodilator effects on the noradrenaline-precontracted isolated rabbit aorta.	Norepinephrine	97-110	natriuretic peptides A	Oryctolagus cuniculus	0-26
5085235-13	1972	In terms of the two muscarinic sites known to be present in the superior cervical ganglion, the receptors of the terminal fibres mediating inhibition of noradrenaline release are more likely to correspond to those mediating hyperpolarization than to those mediating depolarization, for which AHR 602 and McN-A-343 show specificity.	Norepinephrine	153-166	aryl hydrocarbon receptor	Oryctolagus cuniculus	292-295
4403307-1	1972	Activity of serotonin N-acetyltransferase (EC 2.3.1.5) in rat pineal organ is rapidly and markedly elevated in vivo after administration of beta-(3,4-dihydroxyphenyl)-L-alanine (L-DOPA), norepinephrine, epinephrine, isoproterenol, monoamine oxidase inhibitors, or theophylline.	Norepinephrine	187-201	aralkylamine N-acetyltransferase	Rattus norvegicus	12-41
2482450-0	1989	Inhibition of noradrenaline release by neuropeptide Y in mouse atria does not involve inhibition of adenylate cyclase or a pertussis toxin-susceptible G protein.	Norepinephrine	14-27	neuropeptide Y	Mus musculus	39-53
5135722-1	1971	Dopamine-beta-hydroxylase(DBH), the enzyme that catalyzes the conversion of dopamine to norepinephrine, is localized in the vesicles containing catecholamine in sympathetic nerves.	Norepinephrine	88-102	dopamine beta-hydroxylase	Cavia porcellus	0-25
5135722-1	1971	Dopamine-beta-hydroxylase(DBH), the enzyme that catalyzes the conversion of dopamine to norepinephrine, is localized in the vesicles containing catecholamine in sympathetic nerves.	Norepinephrine	88-102	dopamine beta-hydroxylase	Cavia porcellus	26-29
5135722-3	1971	The amount of DBH released is proportional to the amount of norepinephrine released, and the ratio of norepinephrine to DBH discharged into the incubation medium is similar to that in the soluble portion of the contents of the synaptic vesicles from the vas deferens.	Norepinephrine	60-74	dopamine beta-hydroxylase	Cavia porcellus	14-17
4257753-0	1971	[Action of catechol O methyltransferase inhibitors on the distribution of norepinephrine-H 3  in rats].	Norepinephrine	74-88	catechol-O-methyltransferase	Rattus norvegicus	11-39
2512185-2	1989	The intravenous administration of 50 micrograms of TRH produced an increase in plasma epinephrine, cerebral dopamine and a reciprocal decrease in norepinephrine and dopamine in diencephalon and midbrain.	Norepinephrine	146-160	thyrotropin releasing hormone	Rattus norvegicus	51-54
4913714-0	1970	Release of dopamine-beta-hydroxylase with norepinephrine during cat splenic nerve stimulation.	Norepinephrine	42-56	dopamine beta-hydroxylase	Homo sapiens	11-36
2812003-0	1989	Inhibition of noradrenaline release by antibodies to B-50 (GAP-43).	Norepinephrine	14-27	growth associated protein 43	Rattus norvegicus	59-65
4390677-17	1969	The evidence indicates that the release of noradrenaline by DCS 30-40 mug/kg per min from nerve terminals supplying the juxtaglomerular apparatus may have caused the enhancement of renin secretion.	Norepinephrine	43-56	renin	Felis catus	181-186
2551657-1	1989	TSH-releasing factor (TRF), administered into the lateral cerebroventricle of adult male rats, elevated plasma concentrations of ACTH, epinephrine, and norepinephrine.	Norepinephrine	152-166	thyrotropin releasing hormone	Rattus norvegicus	0-20
5351985-0	1969	On the significance of central noradrenaline for motor activity: experiments with a new dopamine beta-hydroxylase inhibitor.	Norepinephrine	31-44	dopamine beta-hydroxylase	Homo sapiens	88-113
2551657-1	1989	TSH-releasing factor (TRF), administered into the lateral cerebroventricle of adult male rats, elevated plasma concentrations of ACTH, epinephrine, and norepinephrine.	Norepinephrine	152-166	thyrotropin releasing hormone	Rattus norvegicus	22-25
5762612-2	1969	Both drugs inhibit dopamine-beta-hydroxylase, the enzyme responsible for the final step in the biosynthesis of norepinephrine.	Norepinephrine	111-125	dopamine beta-hydroxylase	Rattus norvegicus	19-44
2568957-1	1989	The activity of tyrosine hydroxylase (TOH), the rate-limiting enzyme in norepinephrine biosynthesis, was measured in selected sympathetic ganglia to develop a quantitative measure of sympathetic autonomic neuropathy in streptozocin-induced diabetic rats.	Norepinephrine	72-86	tyrosine hydroxylase	Rattus norvegicus	16-36
2572419-1	1989	The stimulant effects of adrenaline and noradrenaline on contractile force and adenylate cyclase, mediated through beta 1 and beta 2-adrenoceptors, are analysed in isolated atrial and ventricular myocardium of man.	Norepinephrine	40-53	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	126-132
2572419-3	1989	Usually, both adrenaline and noradrenaline stimulated adenylate cyclase predominantly through ventricular and atrial beta 2-adrenoceptors.	Norepinephrine	29-42	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	117-123
2572419-8	1989	Noradrenaline can increase atrial and ventricular contractile force through beta 2-adrenoceptors but only at high concentrations.	Norepinephrine	0-13	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	76-82
2572419-10	1989	In atria from atenolol-treated patients equi-inotropic concentrations of adrenaline and noradrenaline acting through beta 2 and beta 1-adrenoceptors, respectively, cause similar increases of cyclic AMP and of cyclic AMP-dependent protein kinase activity.	Norepinephrine	88-101	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	117-148
6026255-0	1967	Quantitative aspects of the replacement of norepinephrine by dopamine as a sympathetic transmitter after inhibition of dopamine-beta-hydroxylase by disulfiram.	Norepinephrine	43-57	dopamine beta-hydroxylase	Homo sapiens	119-144
2565196-2	1989	Epinephrine, norepinephrine, isoproterenol, dopamine, and the specific alpha 2-adrenergic agonists clonidine and p-aminoclonidine exhibit dose-dependent inhibition of VIP-stimulated cyclic AMP production.	Norepinephrine	13-27	VIP peptides	Oryctolagus cuniculus	167-170
13785077-1	1961	HC1 on DOPA, dopamine, norepinephrine, epinephrine and serotonin levels in mouse brain.	Norepinephrine	23-37	heterochromatin, Chr 1	Mus musculus	0-3
2468921-8	1989	In human ventricular membranes xamoterol stimulated marginally the adenylate cyclase and antagonized the effects of (-)-norepinephrine with a 30-fold greater affinity for beta 1- than for beta 2-adrenoceptors.	Norepinephrine	116-134	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	188-194
3241255-4	1988	Protein kinase C inhibitor H-7 and the calmodulin antagonist W-7 inhibited the stimulation-evoked noradrenaline release and pressor responses, respectively, in a dose-dependent manner.	Norepinephrine	98-111	calmodulin 1	Rattus norvegicus	39-49
33952633-2	2021	In fact, the locus coeruleus (LC), the sole source of norepinephrine (NE) for >90% of the brain, is the first site of pathological tau accumulation in human AD with axon loss throughout forebrain, including hippocampus.	Norepinephrine	54-68	microtubule associated protein tau	Homo sapiens	131-134
3201126-3	1988	By means of a spectrofluorometric technique, gastric and duodenal norepinephrine concentrations and duodenal dopamine concentrations were measured and found to be increased in animals treated with the MAO inhibitor.	Norepinephrine	66-80	monoamine oxidase A	Rattus norvegicus	201-204
2900601-4	1988	Norepinephrine, however, increased contractile force solely via beta 1-adrenoceptor stimulation.	Norepinephrine	0-14	adrenoceptor beta 1	Homo sapiens	64-83
33904806-9	2021	Epinephrine and norepinephrine significantly decreased LPS-stimulated production of TNF-alpha, compared with the control.	Norepinephrine	16-30	tumor necrosis factor	Canis lupus familiaris	84-93
33904806-12	2021	CONCLUSIONS AND CLINICAL RELEVANCE: Epinephrine and norepinephrine, but not dobutamine, had immunomodulatory effects on LPS-stimulated TNF-alpha and IL-10 production in blood from healthy dogs in this in vitro model of sepsis.	Norepinephrine	52-66	tumor necrosis factor	Canis lupus familiaris	135-144
3292327-0	1988	Effects of insulin on vasoconstrictive responses to norepinephrine and angiotensin II in rabbit femoral artery and vein.	Norepinephrine	52-66	insulin	Oryctolagus cuniculus	11-18
33895869-5	2021	The exclusion of norepinephrine (NE) from synaptic vesicles leads to its oxidation into the toxic metabolite 3,4-dihydroxyphenyl glycolaldehyde (DOPEGAL), which subsequently activates cleavage of Tau at N368 by asparagine endopeptidase (AEP) and triggers LC neurodegeneration.	Norepinephrine	17-31	microtubule associated protein tau	Homo sapiens	196-199
3409003-0	1988	Effect of monoamine oxidase inhibition on the regional cerebral blood flow response to circulating noradrenaline.	Norepinephrine	99-112	monoamine oxidase A	Rattus norvegicus	10-27
3409003-2	1988	infusion of noradrenaline (NA) on regional cerebral blood flow (rCBF) was investigated in the awake rat using [14C]iodoantipyrine as diffusible tracer.	Norepinephrine	12-25	CCAAT/enhancer binding protein zeta	Rattus norvegicus	64-68
33515860-3	2021	Experimental studies reported that norepinephrine (NE) has the ability to disrupt Tau filament and cause Tau degradation.	Norepinephrine	35-49	microtubule associated protein tau	Homo sapiens	82-85
3262067-2	1988	CGRP was found to inhibit norepinephrine-induced contraction but not KCl- or vasopressin-induced contraction.	Norepinephrine	26-40	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
3380104-6	1988	Adjacent sections were examined for the mRNAs encoding enkephalin and phenylethanolamine N-methyltransferase (PNMT), the enzyme that catalyzes the formation of epinephrine from norepinephrine.	Norepinephrine	177-191	phenylethanolamine N-methyltransferase	Bos taurus	70-108
3380104-6	1988	Adjacent sections were examined for the mRNAs encoding enkephalin and phenylethanolamine N-methyltransferase (PNMT), the enzyme that catalyzes the formation of epinephrine from norepinephrine.	Norepinephrine	177-191	phenylethanolamine N-methyltransferase	Bos taurus	110-114
3260987-0	1988	Systemic interleukin-1 administration stimulates hypothalamic norepinephrine metabolism parallelling the increased plasma corticosterone.	Norepinephrine	62-76	interleukin 1 complex	Mus musculus	9-22
3260987-1	1988	Intraperitoneal injection of purified recombinant interleukin-1 (IL-1) into mice increased the cerebral concentration of the norepinephrine (NE) catabolite, 3-methoxy,4-hydroxyphenylethyleneglycol (MHPG), probably reflecting increased activity of noradrenergic neurons.	Norepinephrine	125-139	interleukin 1 complex	Mus musculus	50-63
3260987-1	1988	Intraperitoneal injection of purified recombinant interleukin-1 (IL-1) into mice increased the cerebral concentration of the norepinephrine (NE) catabolite, 3-methoxy,4-hydroxyphenylethyleneglycol (MHPG), probably reflecting increased activity of noradrenergic neurons.	Norepinephrine	125-139	interleukin 1 complex	Mus musculus	65-69
2824755-9	1987	Noradrenaline (5-500 microM) produced a Ca++-dependent release of a nucleotide which was subsequently degraded extracellularly to adenosine by ecto-5"-nucleotidase.	Norepinephrine	0-13	5' nucleotidase, ecto	Rattus norvegicus	143-163
2439545-6	1987	Atrial natriuretic peptide does not alter basal [Ca2+]i nor inhibit the [Ca2+]i transient induced by either histamine or angiotensin II, but blocks that induced by norepinephrine, and blocks the plateau phase induced by either histamine or norepinephrine.	Norepinephrine	164-178	natriuretic peptides A	Oryctolagus cuniculus	0-26
2889157-4	1987	In this study, it has been shown that inhibition of phenylethanolamine-N-methyltransferase selectively decreases tissue levels in the hypothalamus and in vivo release of adrenaline, while monoamine oxidase inhibition and antagonism of alpha 2-adrenoceptors increases the release of both adrenaline and noradrenaline.	Norepinephrine	302-315	phenylethanolamine N-methyltransferase	Homo sapiens	52-90
3626024-0	1987	Effects of calmodulin antagonists on norepinephrine release and vascular responsiveness in rat mesenteric vasculature.	Norepinephrine	37-51	calmodulin 1	Rattus norvegicus	11-21
3626024-3	1987	Pressor responses to electrical nerve stimulation or exogenous norepinephrine were inhibited dose-dependently by each calmodulin antagonist.	Norepinephrine	63-77	calmodulin 1	Rattus norvegicus	118-128
3626024-4	1987	Norepinephrine overflow from the sympathetic nerve endings during electrical nerve stimulation was also suppressed by calmodulin antagonists.	Norepinephrine	0-14	calmodulin 1	Rattus norvegicus	118-128
2829863-0	1987	Adrenaline and noradrenaline increase contractile force of human ventricle through both beta 1- and beta 2-adrenoceptors.	Norepinephrine	15-28	adrenoceptor beta 1	Homo sapiens	88-120
2829863-5	1987	Low adrenaline concentrations and high noradrenaline concentrations can increase contractile strength by up to 50% of maximum through beta 2.	Norepinephrine	39-52	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	134-140
3114792-4	1987	These results are consistent with MAO-A and non-selective MAO inhibitors acting via blockade of degradation of the preferential substrates of MAO-A, serotonin and/or norepinephrine, in adrenergic neurons entering the pineal gland.	Norepinephrine	166-180	monoamine oxidase A	Macaca mulatta	34-39
3809607-3	1986	Neurochemical evidence has been obtained that neuropeptide Y (NPY), although it co-exists and is released with (-)-noradrenaline (NA), it behaves differently as far as its effect on presynaptic modulation of chemical neurotransmission is concerned.	Norepinephrine	111-128	neuropeptide Y	Mus musculus	46-60
3809607-3	1986	Neurochemical evidence has been obtained that neuropeptide Y (NPY), although it co-exists and is released with (-)-noradrenaline (NA), it behaves differently as far as its effect on presynaptic modulation of chemical neurotransmission is concerned.	Norepinephrine	111-128	neuropeptide Y	Mus musculus	62-65
2434752-6	1986	In addition, on atria and on ventricles, adenylate cyclase was activated by norepinephrine (presumably by beta 1- and beta 2-adrenoceptor stimulation) and by procaterol (by beta 2-adrenoceptor stimulation).	Norepinephrine	76-90	adrenoceptor beta 1	Homo sapiens	106-137
3550037-1	1986	Effects of labetalol, a combined alpha- and beta-adrenoceptor blocking agent, on the changes in renin release in response to isoproterenol or norepinephrine were examined in comparison with those of propranolol and prazosin, using rat kidney cortical slices.	Norepinephrine	142-156	renin	Rattus norvegicus	96-101
3550037-7	1986	The decreased response of renin release to 10(-5) M norepinephrine was significantly inhibited by labetalol over 10(-6) M. Labetalol, at a concentration of 10(-5) M, abolished the decreased release by 10(-5) M norepinephrine.	Norepinephrine	52-66	renin	Rattus norvegicus	26-31
3550037-7	1986	The decreased response of renin release to 10(-5) M norepinephrine was significantly inhibited by labetalol over 10(-6) M. Labetalol, at a concentration of 10(-5) M, abolished the decreased release by 10(-5) M norepinephrine.	Norepinephrine	210-224	renin	Rattus norvegicus	26-31
3550037-8	1986	On the other hand, the decreasing effect of 10(-5) M norepinephrine was substantially reversed rather than abolished by prazosin over 10(-7) M. These results indicate that labetalol inhibited the response of renin in rat kidney cortical slices, by beta- and alpha 1-adrenoceptor antagonistic action, respectively.	Norepinephrine	53-67	renin	Rattus norvegicus	208-213
3020011-2	1986	The demonstration that membrane receptors for norepinephrine are coupled in a stimulatory (beta 1, beta 2) or inhibitory (alpha 2) way via nucleotide regulatory proteins to adenylate cyclase, thus increasing or decreasing the formation of the second messenger cyclic AMP, is discussed.	Norepinephrine	46-60	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	99-105
33515860-3	2021	Experimental studies reported that norepinephrine (NE) has the ability to disrupt Tau filament and cause Tau degradation.	Norepinephrine	35-49	microtubule associated protein tau	Homo sapiens	105-108
33855088-4	2021	Results: The norepinephrine levels were markedly high in gastric cancer tissue, while the norepinephrine-degrading enzymes MAOA and MAOB showed low expression.	Norepinephrine	90-104	monoamine oxidase A	Homo sapiens	123-127
3023761-5	1986	Norepinephrine and epinephrine inhibited the capacity of gamma interferon and lipopolysaccharide to stimulate IL-1 production from mouse peritoneal macrophages.	Norepinephrine	0-14	interleukin 1 complex	Mus musculus	110-114
3023761-8	1986	This, coupled with the capacity of norepinephrine and epinephrine to enhance intracellular cAMP levels in macrophages, strongly suggested that the catecholamine-induced suppression of IL-1 production may be mediated by elevated intracellular cAMP levels.	Norepinephrine	35-49	interleukin 1 complex	Mus musculus	184-188
3785579-7	1986	Oxidation of norepinephrine, serotonin, octopamine, tyramine and dopamine by monoamine oxidase (MAO), an enzyme marker of the outer mitochondrial membrane, was inhibited in the presence of 0.01 to 0.1 mM of chlorphentermine.	Norepinephrine	13-27	monoamine oxidase A	Rattus norvegicus	77-94
3785579-7	1986	Oxidation of norepinephrine, serotonin, octopamine, tyramine and dopamine by monoamine oxidase (MAO), an enzyme marker of the outer mitochondrial membrane, was inhibited in the presence of 0.01 to 0.1 mM of chlorphentermine.	Norepinephrine	13-27	monoamine oxidase A	Rattus norvegicus	96-99
3758168-1	1986	Neuropeptide Y (NPY) is known to occur in adrenergic nerves within the thyroid gland and may thus be released concomitantly with noradrenaline upon adrenergic activation.	Norepinephrine	129-142	neuropeptide Y	Mus musculus	0-14
3758168-1	1986	Neuropeptide Y (NPY) is known to occur in adrenergic nerves within the thyroid gland and may thus be released concomitantly with noradrenaline upon adrenergic activation.	Norepinephrine	129-142	neuropeptide Y	Mus musculus	16-19
3758168-5	1986	Noradrenaline inhibited the TSH-induced thyroid hormone secretion to 168 +/- 6% (P less than 0.01), and NPY potentiated this inhibitory action of noradrenaline (P less than 0.01): the TSH-induced thyroid hormone secretion was only 19 +/- 6% after administration of both noradrenaline and NPY.	Norepinephrine	146-159	neuropeptide Y	Mus musculus	104-107
3758168-5	1986	Noradrenaline inhibited the TSH-induced thyroid hormone secretion to 168 +/- 6% (P less than 0.01), and NPY potentiated this inhibitory action of noradrenaline (P less than 0.01): the TSH-induced thyroid hormone secretion was only 19 +/- 6% after administration of both noradrenaline and NPY.	Norepinephrine	146-159	neuropeptide Y	Mus musculus	288-291
3758168-5	1986	Noradrenaline inhibited the TSH-induced thyroid hormone secretion to 168 +/- 6% (P less than 0.01), and NPY potentiated this inhibitory action of noradrenaline (P less than 0.01): the TSH-induced thyroid hormone secretion was only 19 +/- 6% after administration of both noradrenaline and NPY.	Norepinephrine	270-283	neuropeptide Y	Mus musculus	104-107
3022838-2	1986	It was found that a 4 hr cold stress led to a 7-fold increase in the amount of thermogenin mRNA; injection of norepinephrine had a significant but smaller effect.	Norepinephrine	110-124	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	79-90
33855088-8	2021	The norepinephrine-degrading enzymes MAOA and MAOB have significant expression differences in cancer and normal tissue, and their missing or low expression may predict immune therapy outcomes for gastric cancer patients.	Norepinephrine	4-18	monoamine oxidase A	Homo sapiens	37-41
33388353-4	2021	These results suggest that neonatal overfeeding in female rats promotes reproductive dysfunctions in adulthood, such as lower estradiol plasma levels associated with impairments in fertility and noradrenaline-kisspeptin-GnRH pathway during positive feedback.	Norepinephrine	195-208	gonadotropin releasing hormone 1	Rattus norvegicus	220-224
33687595-2	2021	This effect is mediated via sympathetic nervous stimulation of PVAT by a mechanism which involves noradrenaline uptake through organic cation transporter 3 (OCT3) and beta3-adrenoceptor-mediated adiponectin release.	Norepinephrine	98-111	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	127-155
33687595-2	2021	This effect is mediated via sympathetic nervous stimulation of PVAT by a mechanism which involves noradrenaline uptake through organic cation transporter 3 (OCT3) and beta3-adrenoceptor-mediated adiponectin release.	Norepinephrine	98-111	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	157-161
33750832-2	2021	We show that, in comparison to the 11 artiodactyl brains studied (from 11 species), the 5 cetacean brains (from 3 species), exhibit an expanded expression of uncoupling protein 1 (UCP1, UCPs being mitochondrial inner membrane proteins that dissipate the proton gradient to generate heat) in cortical neurons, immunolocalization of UCP4 within a substantial proportion of glia throughout the brain, and an increased density of noradrenergic axonal boutons (noradrenaline functioning to control concentrations of and activate UCPs).	Norepinephrine	456-469	uncoupling protein 1	Homo sapiens	158-178
33750832-2	2021	We show that, in comparison to the 11 artiodactyl brains studied (from 11 species), the 5 cetacean brains (from 3 species), exhibit an expanded expression of uncoupling protein 1 (UCP1, UCPs being mitochondrial inner membrane proteins that dissipate the proton gradient to generate heat) in cortical neurons, immunolocalization of UCP4 within a substantial proportion of glia throughout the brain, and an increased density of noradrenergic axonal boutons (noradrenaline functioning to control concentrations of and activate UCPs).	Norepinephrine	456-469	uncoupling protein 1	Homo sapiens	180-184
33746717-7	2021	Immunolabeling for dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT), enzymes responsible for the synthesis of norepinephrine (NE) and epinephrine (E), respectively, were evaluated.	Norepinephrine	143-157	dopamine beta-hydroxylase	Rattus norvegicus	19-44
3762738-1	1986	Utilizing a specific "low substrate concentration technique", intrasynaptosomal MAO-A and MAO-B activities within the rat brain noradrenaline system were studied.	Norepinephrine	128-141	monoamine oxidase A	Rattus norvegicus	80-85
3762738-3	1986	It is suggested that the intrasynaptosomal pool of MAO in the noradrenaline and the dopamine systems may reflect the density of innervation of the respective system throughout the brain.	Norepinephrine	62-75	monoamine oxidase A	Rattus norvegicus	51-54
33746717-7	2021	Immunolabeling for dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT), enzymes responsible for the synthesis of norepinephrine (NE) and epinephrine (E), respectively, were evaluated.	Norepinephrine	143-157	dopamine beta-hydroxylase	Rattus norvegicus	46-49
33746717-7	2021	Immunolabeling for dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT), enzymes responsible for the synthesis of norepinephrine (NE) and epinephrine (E), respectively, were evaluated.	Norepinephrine	143-157	phenylethanolamine-N-methyltransferase	Rattus norvegicus	95-99
33434145-7	2021	Exposure of excess norepinephrine significantly restricted the induced expression of decidualized markers Dtprp, BMP2, WNT4, and Hand2 in mice.	Norepinephrine	19-33	heart and neural crest derivatives expressed 2	Mus musculus	129-134
33434145-10	2021	The alpha1b-adrenergic receptor expression was upregulated by norepinephrine.	Norepinephrine	62-76	adrenergic receptor, alpha 1b	Mus musculus	4-31
33434145-11	2021	Interestingly, norepinephrine did not inhibit the expression of IGFBP1 in endometrial stromal cells after silencing alpha1b-adrenergic receptor, while significantly suppressed the induced decidualization with overexpression of alpha1b-adrenergic receptor.	Norepinephrine	15-29	adrenergic receptor, alpha 1b	Mus musculus	227-254
33434145-12	2021	When alpha1b-adrenergic receptor was activated, endometrial p-PKC was significantly increased under post-treatment with norepinephrine in vivo and in vitro.	Norepinephrine	120-134	adrenergic receptor, alpha 1b	Mus musculus	5-32
33434145-14	2021	Therefore, norepinephrine exposure inhibited endometrial decidualization through the activation of the PKC signaling pathway by upregulating alpha1b-adrenergic receptor.	Norepinephrine	11-25	adrenergic receptor, alpha 1b	Mus musculus	141-168
33548763-6	2021	Dopamine beta hydroxylase determines the ratio of dopamine to norepinephrine.	Norepinephrine	62-76	dopamine beta-hydroxylase	Homo sapiens	0-25
3525199-0	1986	The different effects of exogenous and neuronally released norepinephrine on renin release in rat kidney cortical slices.	Norepinephrine	59-73	renin	Rattus norvegicus	77-82
33484195-0	2021	Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation.	Norepinephrine	0-14	adrenergic receptor, beta 2	Mus musculus	64-89
32954502-4	2021	These observations suggest that noradrenaline protects neurons from oxidative stress-induced death by increasing the supply of GSH from astrocytes to neurons via the stimulation of beta3 -adrenoceptor in astrocytes.	Norepinephrine	32-45	adrenoceptor beta 3	Homo sapiens	181-200
32954502-7	2021	The neuroprotective effect of noradrenaline was inhibited by SR59230A, a selective beta3 -adrenoceptor antagonist, and CL316243, a selective beta3 -adrenoceptor agonist, mimicked the neuroprotective effect of noradrenaline.	Norepinephrine	30-43	adrenoceptor beta 3	Homo sapiens	83-102
33183171-1	2021	RATIONALE: beta1-adrenoceptors (beta1ARs) exist at intracellular membranes and Organic Cation Transporter 3 (OCT3) mediates norepinephrine entry into cardiomyocytes.	Norepinephrine	124-138	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	79-107
33183171-1	2021	RATIONALE: beta1-adrenoceptors (beta1ARs) exist at intracellular membranes and Organic Cation Transporter 3 (OCT3) mediates norepinephrine entry into cardiomyocytes.	Norepinephrine	124-138	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	109-113
33183171-7	2021	The same was true at the PM for membrane-impermeant norepinephrine, but the SR response to norepinephrine was suppressed in OCT3KO myocytes.	Norepinephrine	91-105	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	124-130
33183171-9	2021	Similarly, OCT3KO selectively suppressed calcium transients and contraction responses to norepinephrine, but not isoproterenol.	Norepinephrine	89-103	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	11-17
33183171-11	2021	Moreover, pretreatment with sotatol in OCT3KO myocytes prevented norepinephrine induced PKA activation at both PM and the SR and contractility.	Norepinephrine	65-79	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	39-45
33476175-4	2020	The aim of the present study was to experimentally examine the anti-nociceptive effects of tapentadol, an opioid agonist and a norepinephrine reuptake inhibitor (MOR/NRI), in our animal model of orofacial pain.	Norepinephrine	127-141	opioid receptor mu 1	Homo sapiens	162-165
2428551-1	1986	The effects of arotinolol on changes in renin release in rat kidney cortical slices in response to isoproterenol (IP) or norepinephrine (NE), were studied in comparison with those of AC-623, a main metabolite of arotinolol, and other typical adrenoceptor antagonists.	Norepinephrine	121-135	renin	Rattus norvegicus	40-45
32942081-1	2020	Monoamine oxidases (MAO-A and MAO-B) are mammalian flavoenzyme, which catalyze the oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine, serotonin, and some other amines.	Norepinephrine	139-153	monoamine oxidase A	Homo sapiens	20-25
33171955-3	2020	)), a selective inhibitor of phenylethanolamine N-methyltransferase (PNMT) that converts noradrenaline (NA) into adrenaline (A), fully reverted mechanical allodynia in the injured hind paw without affecting mechanical sensitivity in the contralateral paw.	Norepinephrine	89-102	phenylethanolamine-N-methyltransferase	Rattus norvegicus	29-67
33171955-3	2020	)), a selective inhibitor of phenylethanolamine N-methyltransferase (PNMT) that converts noradrenaline (NA) into adrenaline (A), fully reverted mechanical allodynia in the injured hind paw without affecting mechanical sensitivity in the contralateral paw.	Norepinephrine	89-102	phenylethanolamine-N-methyltransferase	Rattus norvegicus	69-73
32607551-0	2020	Noradrenaline Release from Locus Coeruleus Terminals in the Hippocampus Enhances Excitation-Spike Coupling in CA1 Pyramidal Neurons Via beta-Adrenoceptors.	Norepinephrine	0-13	carbonic anhydrase 1	Mus musculus	110-113
32607551-2	2020	Noradrenaline is therefore expected to enhance hippocampal responses to synaptic input; however, noradrenergic agonists have been found to have mixed and sometimes contradictory effects on Schaffer collateral synapses and the resulting CA1 output.	Norepinephrine	0-13	carbonic anhydrase 1	Mus musculus	236-239
32607551-3	2020	Here, we examine the effects of endogenous, optogenetically driven noradrenaline release on synaptic transmission and spike output in mouse hippocampal CA1 pyramidal neurons.	Norepinephrine	67-80	carbonic anhydrase 1	Mus musculus	152-155
32607551-4	2020	We show that endogenous noradrenaline release enhances the probability of CA1 pyramidal neuron spiking without altering feedforward excitatory or inhibitory synaptic inputs in the Schaffer collateral pathway.	Norepinephrine	24-37	carbonic anhydrase 1	Mus musculus	74-77
32985027-0	2020	Noradrenaline signaling in the LPBN mediates amylin"s and salmon calcitonin"s hypophagic effect in male rats.	Norepinephrine	0-13	islet amyloid polypeptide	Rattus norvegicus	45-51
2426539-5	1986	Hypothalamic levels of norepinephrine were decreased during hypoxia [(inhibition of TH, MAO, and dopamine beta-hydroxylase (DBH)].	Norepinephrine	23-37	monoamine oxidase A	Rattus norvegicus	88-91
3517539-0	1986	An improved radioenzymatic assay for plasma norepinephrine using purified phenylethanolamine N-methyltransferase.	Norepinephrine	44-58	phenylethanolamine N-methyltransferase	Homo sapiens	74-112
3517539-1	1986	Radioenzymatic assays have been developed for norepinephrine (NE) using either catechol O-methyltransferase (COMT) or phenylethanolamine N-methyltransferase (PNMT).	Norepinephrine	46-60	catechol-O-methyltransferase	Homo sapiens	79-107
3517539-1	1986	Radioenzymatic assays have been developed for norepinephrine (NE) using either catechol O-methyltransferase (COMT) or phenylethanolamine N-methyltransferase (PNMT).	Norepinephrine	46-60	catechol-O-methyltransferase	Homo sapiens	109-113
3517539-1	1986	Radioenzymatic assays have been developed for norepinephrine (NE) using either catechol O-methyltransferase (COMT) or phenylethanolamine N-methyltransferase (PNMT).	Norepinephrine	46-60	phenylethanolamine N-methyltransferase	Homo sapiens	118-156
3517539-1	1986	Radioenzymatic assays have been developed for norepinephrine (NE) using either catechol O-methyltransferase (COMT) or phenylethanolamine N-methyltransferase (PNMT).	Norepinephrine	46-60	phenylethanolamine N-methyltransferase	Homo sapiens	158-162
32896003-2	2020	Dopamine beta-hydroxylase (DbetaH) plays a key role in the conversion of dopamine to norepinephrine, which is related to suicidal behavior and cognitive regulation.	Norepinephrine	85-99	dopamine beta-hydroxylase	Homo sapiens	0-25
32750368-4	2020	Noradrenaline and methoxamine increased alpha1A-adrenoceptor interaction with Rab5 and Rab7 but did not modify it with Rab9.	Norepinephrine	0-13	RAB5A, member RAS oncogene family	Homo sapiens	78-82
32512190-5	2020	This indicates that the accumulation of dopamine is not due to its greater production, but its lesser biotransformation into noradrenaline, due to the blockage of the dopamine beta-hydroxylase enzyme by 4-cresol and vitamin C, both found in high quantities in autistic subjects.	Norepinephrine	125-138	dopamine beta-hydroxylase	Homo sapiens	167-192
32632916-10	2020	All diet protocols in male and female restored decreased responsiveness of the myocardium to norepinephrine in hearts obtained from rats with PAH and prevented vascular changes observed in pulmonary hypertension (thickness of blood vessels and cell infiltration).	Norepinephrine	93-107	phenylalanine hydroxylase	Rattus norvegicus	142-145
3008566-1	1986	It was the aim of the present study to get insight into some of the intracellular mechanisms by which the vasoconstrictor hormones angiotensin II (ANG II), arginine vasopressin (AVP), and norepinephrine (NE) inhibit renin release from renal juxtaglomerular cells.	Norepinephrine	188-202	renin	Rattus norvegicus	216-221
32929122-0	2020	Norepinephrine depleting toxin DSP-4 and LPS alter gut microbiota and induce neurotoxicity in alpha-synuclein mutant mice.	Norepinephrine	0-14	synuclein, alpha	Mus musculus	94-109
2874501-6	1986	In the case of dopamine and norepinephrine, these findings suggest a reevaluation of their role for feedback control of tyrosine hydroxylase in vivo.	Norepinephrine	28-42	tyrosine hydroxylase	Rattus norvegicus	120-140
3753600-2	1986	Selectivity of catechol O-methyltransferase has been examined for the three ring-fluorinated norepinephrines to elucidate the role of acidity of the phenolic groups in their methylation.	Norepinephrine	93-108	catechol-O-methyltransferase	Homo sapiens	15-43
3753600-3	1986	Substitution of fluorine at the 5-position of norepinephrine reverses the selectivity of catechol O-methyltransferase so that p-O-methylation predominates.	Norepinephrine	46-60	catechol-O-methyltransferase	Homo sapiens	89-117
3080257-3	1986	In contrast, following TRH administration (4 mg/kg, iv), an increase in mean arterial pressure was associated with significant increases in plasma epinephrine, norepinephrine, and corticosterone.	Norepinephrine	160-174	thyrotropin releasing hormone	Rattus norvegicus	23-26
31943210-6	2020	An in-vivo microdialysis study in EFhd2 knock out (KO) mice revealed that EFhd2 controls METH- and cocaine-induced changes in extracellular dopamine (DA), serotonin and noradrenaline levels through different mechanisms in the nucleus accumbens (NAc) and prefrontal cortex (PFC).	Norepinephrine	169-182	EF hand domain containing 2	Mus musculus	74-79
32473155-12	2020	Ectopic expression of GATA3 enhanced the expression of UCP-1 and thermogenic genes upon treatment with norepinephrine whereas GATA3 knockdown had the opposite effect.	Norepinephrine	103-117	GATA binding protein 3	Mus musculus	22-27
32303180-0	2020	Comparison of two Norepinephrine rescue bolus for Management of Post-spinal Hypotension during Cesarean Delivery: a randomized controlled trial.	Norepinephrine	18-32	solute carrier family 35 member G1	Homo sapiens	64-68
3780787-6	1986	Loading of noradrenaline resulted in restoration of the fluorescence in the sympathetic nerves in the distal colon subjected to 2, but not 3 h, of ischemia.	Norepinephrine	11-24	CCR4-NOT transcription complex subunit 3	Homo sapiens	135-142
32242018-2	2020	In three cohorts of individuals with depression and treated with serotonin-norepinephrine reuptake inhibitor (N = 424) we show that responders, but not non-responders, display an increase of GPR56 mRNA in the blood.	Norepinephrine	75-89	adhesion G protein-coupled receptor G1	Homo sapiens	191-196
32188130-6	2020	We compared in vitro the efficacy of clonidine, dexmedetomidine, brimonidine, and norepinephrine with epinephrine to restore ADP- and PAR-1-AP-induced washed platelet aggregation inhibited by ticagrelor, as well as resulting platelet cAMP levels.	Norepinephrine	82-96	Prader Willi/Angelman region RNA 1	Homo sapiens	134-139
32188130-8	2020	Compared with epinephrine, norepinephrine, and brimonidine partially restored ADP- and fully restored PAR-1-AP-induced aggregation inhibited by ticagrelor while clonidine and dexmedetomidine were ineffective.	Norepinephrine	27-41	Prader Willi/Angelman region RNA 1	Homo sapiens	102-107
31913053-1	2020	BACKGROUND: Dopamine-beta-hydroxylase (DBH, EC 1.14.17.1), which converts dopamine to norepinephrine, is a candidate gene in neuropsychiatric diseases.	Norepinephrine	86-100	dopamine beta-hydroxylase	Homo sapiens	12-37
3025031-3	1986	Depletion of extracellular calcium or addition of calmodulin antagonists trifluoperazine and W7 diminished the contraction and phosphorylation of myosin light chain by norepinephrine, but did not prevent dephosphorylation by sodium nitroprusside or the elevated levels of cyclic GMP.	Norepinephrine	168-182	calmodulin 1	Rattus norvegicus	50-60
3025031-6	1986	The different proteins phosphorylated by norepinephrine showed varying degrees of sensitivity to Ca2+-free solution and to the calmodulin antagonists.	Norepinephrine	41-55	calmodulin 1	Rattus norvegicus	127-137
31913053-1	2020	BACKGROUND: Dopamine-beta-hydroxylase (DBH, EC 1.14.17.1), which converts dopamine to norepinephrine, is a candidate gene in neuropsychiatric diseases.	Norepinephrine	86-100	dopamine beta-hydroxylase	Homo sapiens	39-42
32098331-8	2020	Protein profiling revealed the upregulation of the pro-metastatic gene Ly6/PLAUR Domain-Containing Protein 3 (LYPD3) in norepinephrine-treated MDA-MB-468 cells.	Norepinephrine	120-134	LY6/PLAUR domain containing 3	Homo sapiens	71-108
2439795-5	1986	On isolated electrically driven human right atria, (+/-)-bisoprolol was approximately 30 times more potent in antagonizing the beta 1-adrenoceptor-mediated positive inotropic effect of noradrenaline (pA2-value, 8.42) than the beta 2-adrenoceptor-mediated positive inotropic effect of procaterol (pA2-value, 6.99).	Norepinephrine	185-198	adrenoceptor beta 1	Homo sapiens	127-146
3945626-1	1986	A rapid, highly sensitive assay for phenylethanolamine N-methyltransferase in brain using the natural substrate, norepinephrine, is described.	Norepinephrine	113-127	phenylethanolamine N-methyltransferase	Homo sapiens	36-74
3900340-7	1985	The hemodynamic responses to exogenous norepinephrine were affected by inhibition of the renin-angiotensin system with captopril and saralasin in a manner analogous to the neurally mediated responses.	Norepinephrine	39-53	renin	Rattus norvegicus	89-94
2999616-14	1985	(-)-Propranolol antagonized the effects of (-)-noradrenaline mediated by beta 2-adrenoceptors 2 to 3 times more potently than the effects mediated by beta 1-adrenoceptors.	Norepinephrine	43-60	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	73-79
4085156-5	1985	It is conceivable that the higher luteal phase noradrenaline is causally related to the higher oestradiol levels, leading to incomplete inactivation by reducing tissue uptake or competitive inhibition of catechol-O-methyl transferase.	Norepinephrine	47-60	catechol-O-methyltransferase	Homo sapiens	204-233
4063469-0	1985	Cold exposure or chronic noradrenaline treatment induces an increase in the calmodulin-like immunoreactivity of brown adipose tissue of rats.	Norepinephrine	25-38	calmodulin 1	Rattus norvegicus	76-86
2413370-6	1985	Levels of dopamine and noradrenaline were both increased in rat frontal cortex after the administration of N-0425, which can be interpreted as a reflection of MAO inactivation.	Norepinephrine	23-36	monoamine oxidase A	Rattus norvegicus	159-162
3999927-6	1985	Although a high microvessel MAO activity (2.2 +/- 0.3 nmol min-1 mg prot.-1) was found using noradrenaline as substrate, significantly higher rates were found with tyramine, serotonin and beta-phenyl-ethylamine.	Norepinephrine	93-106	monoamine oxidase A	Rattus norvegicus	28-31
2989497-0	1985	Inhibitory effects of norepinephrine, methoxamine and phenylephrine on renin release from rat kidney cortical slices.	Norepinephrine	22-36	renin	Rattus norvegicus	71-76
2989497-2	1985	Norepinephrine (NE), methoxamine (ME) and phenylephrine (PE) produced a concentration-dependent inhibition of renin release from rat kidney cortical slices, whereas clonidine was without effect.	Norepinephrine	0-14	renin	Rattus norvegicus	110-115
3923755-4	1985	During a TRH-test, norepinephrine levels remained elevated (P less than 0.001) in the active group, and the difference between the 2 groups was enhanced during the test.	Norepinephrine	19-33	thyrotropin releasing hormone	Homo sapiens	9-12
3923755-5	1985	On the other hand the 2 patients who responded to TRH demonstrated an increase of norepinephrine levels.	Norepinephrine	82-96	thyrotropin releasing hormone	Homo sapiens	50-53
3923755-6	1985	Our results suggest that TRH may stimulate norepinephrine release in acromegalics with an active response to TRH.	Norepinephrine	43-57	thyrotropin releasing hormone	Homo sapiens	25-28
4092239-2	1985	Norepinephrine levels were elevated in the traumatized segment at 1/2, 2, and 4 hours after contusion injury and in the adjacent nontraumatized segment at 1/2 hour.	Norepinephrine	0-14	angiotensin II receptor type 1	Homo sapiens	63-72
4092239-2	1985	Norepinephrine levels were elevated in the traumatized segment at 1/2, 2, and 4 hours after contusion injury and in the adjacent nontraumatized segment at 1/2 hour.	Norepinephrine	0-14	angiotensin II receptor type 1	Homo sapiens	63-67
6149980-3	1984	The contents of EGF in the submandibular glands decreased upon administration of the alpha-adrenergic agonist noradrenaline, and this was confirmed on immunohistochemical investigation of the glands.	Norepinephrine	110-123	epidermal growth factor like 1	Rattus norvegicus	16-19
6088536-8	1984	Pulse-label and pulse-chase studies indicate that the conversion rate of phosphocholine to CDP-choline, catalyzed by CTP:phosphocholine cytidylyltransferase, is diminished by norepinephrine.	Norepinephrine	175-189	cut-like homeobox 1	Rattus norvegicus	91-94
32098331-8	2020	Protein profiling revealed the upregulation of the pro-metastatic gene Ly6/PLAUR Domain-Containing Protein 3 (LYPD3) in norepinephrine-treated MDA-MB-468 cells.	Norepinephrine	120-134	LY6/PLAUR domain containing 3	Homo sapiens	110-115
32098331-11	2020	This study also highlights the first association between ADRbeta2 signalling and LYPD3; its knockdown significantly reduced the basal and norepinephrine-induced activity of MCF-7 cells in vitro.	Norepinephrine	138-152	LY6/PLAUR domain containing 3	Homo sapiens	81-86
32009887-5	2019	Furthermore, we measured the expression of the noradrenaline biosynthetic enzyme dopamine-beta-hydroxylase (DBH) and of alpha2 -AR in the spinal dorsal horn.	Norepinephrine	47-60	dopamine beta-hydroxylase	Rattus norvegicus	81-106
32009887-5	2019	Furthermore, we measured the expression of the noradrenaline biosynthetic enzyme dopamine-beta-hydroxylase (DBH) and of alpha2 -AR in the spinal dorsal horn.	Norepinephrine	47-60	dopamine beta-hydroxylase	Rattus norvegicus	108-111
31793911-0	2020	Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus.	Norepinephrine	0-14	microtubule associated protein tau	Homo sapiens	65-68
31793911-3	2020	Here, we show that 3,4-dihydroxyphenylglycolaldehyde, which is produced exclusively in noradrenergic neurons by monoamine oxidase A metabolism of norepinephrine, activated asparagine endopeptidase that cleaved Tau at residue N368 into aggregation- and propagation-prone forms, thus leading to LC degeneration and the spread of Tau pathology.	Norepinephrine	146-160	monoamine oxidase A	Homo sapiens	112-131
31793911-3	2020	Here, we show that 3,4-dihydroxyphenylglycolaldehyde, which is produced exclusively in noradrenergic neurons by monoamine oxidase A metabolism of norepinephrine, activated asparagine endopeptidase that cleaved Tau at residue N368 into aggregation- and propagation-prone forms, thus leading to LC degeneration and the spread of Tau pathology.	Norepinephrine	146-160	microtubule associated protein tau	Homo sapiens	210-213
31793911-3	2020	Here, we show that 3,4-dihydroxyphenylglycolaldehyde, which is produced exclusively in noradrenergic neurons by monoamine oxidase A metabolism of norepinephrine, activated asparagine endopeptidase that cleaved Tau at residue N368 into aggregation- and propagation-prone forms, thus leading to LC degeneration and the spread of Tau pathology.	Norepinephrine	146-160	microtubule associated protein tau	Homo sapiens	327-330
31468359-2	2020	In nasal mucosa, high concentrations of NPY are stored with noradrenaline in sympathetic nerve fibers.	Norepinephrine	60-73	neuropeptide Y	Homo sapiens	40-43
31875545-3	2019	Norepinephrine activates alpha1 adrenoreceptors in hypothalamic corticotropin-releasing hormone (CRH) neurons to stimulate dendritic release, which triggers an astrocytic calcium response and release of ATP; ATP stimulates action potentials in upstream glutamate and GABA neurons to activate recurrent excitatory and inhibitory synaptic circuits to the CRH neurons.	Norepinephrine	0-14	corticotropin releasing hormone	Homo sapiens	64-95
31875545-3	2019	Norepinephrine activates alpha1 adrenoreceptors in hypothalamic corticotropin-releasing hormone (CRH) neurons to stimulate dendritic release, which triggers an astrocytic calcium response and release of ATP; ATP stimulates action potentials in upstream glutamate and GABA neurons to activate recurrent excitatory and inhibitory synaptic circuits to the CRH neurons.	Norepinephrine	0-14	corticotropin releasing hormone	Homo sapiens	97-100
31875545-3	2019	Norepinephrine activates alpha1 adrenoreceptors in hypothalamic corticotropin-releasing hormone (CRH) neurons to stimulate dendritic release, which triggers an astrocytic calcium response and release of ATP; ATP stimulates action potentials in upstream glutamate and GABA neurons to activate recurrent excitatory and inhibitory synaptic circuits to the CRH neurons.	Norepinephrine	0-14	corticotropin releasing hormone	Homo sapiens	353-356
31875545-4	2019	Thus, norepinephrine activates a retrograde signaling mechanism in CRH neurons that engages astrocytes in order to extend dendritic volume transmission to reach distal presynaptic glutamate and GABA neurons, thereby amplifying volume transmission mediated by dendritic release.	Norepinephrine	6-20	corticotropin releasing hormone	Homo sapiens	67-70
31411815-8	2019	Norepinephrine and cyclic adenosine monophosphate induced GDF15 expression and release by cells through protein kinase A-mediated mechanisms.	Norepinephrine	0-14	growth differentiation factor 15	Mus musculus	58-63
32259069-2	2019	One strategy to mitigate the SNS overdrive is by restricting the biosynthesis of norepinephrine via the inhibition of dopamine beta-hydroxylase (DBH).	Norepinephrine	81-95	dopamine beta-hydroxylase	Rattus norvegicus	118-143
32259069-2	2019	One strategy to mitigate the SNS overdrive is by restricting the biosynthesis of norepinephrine via the inhibition of dopamine beta-hydroxylase (DBH).	Norepinephrine	81-95	dopamine beta-hydroxylase	Rattus norvegicus	145-148
32259069-3	2019	Zamicastat is a new DBH inhibitor that decreases norepinephrine and increases dopamine levels in peripherally sympathetic-innervated tissues.	Norepinephrine	49-63	dopamine beta-hydroxylase	Rattus norvegicus	20-23
32259069-13	2019	In conclusion, DBH inhibition decreased norepinephrine levels, reduced end-organ damage, and improved cardiometabolic and inflammatory biomarkers in aged male SHRs.	Norepinephrine	40-54	dopamine beta-hydroxylase	Rattus norvegicus	15-18
31265749-2	2019	Dopamine beta hydroxylase (DBH) encodes a copper-dependent mono-oxygenase that converts dopamine to norepinephrine, thereby regulating the endogenous dopamine content in the neurons.	Norepinephrine	100-114	dopamine beta-hydroxylase	Homo sapiens	0-25
6381275-3	1984	The plasma levels of insulin were increased by beta-receptor stimulation (isoproterenol, phentolamine + epinephrine) and decreased by alpha-receptor stimulation (epinephrine, norepinephrine, propranolol + epinephrine).	Norepinephrine	175-189	insulin	Oryctolagus cuniculus	21-28
31265749-2	2019	Dopamine beta hydroxylase (DBH) encodes a copper-dependent mono-oxygenase that converts dopamine to norepinephrine, thereby regulating the endogenous dopamine content in the neurons.	Norepinephrine	100-114	dopamine beta-hydroxylase	Homo sapiens	27-30
30456877-1	2019	The monoamine oxidase A (MAOA) enzyme metabolizes monoamine neurotransmitters such as dopamine, serotonin and norepinephrine, and its genetic polymorphism (rs1137070) influences its activity level and is associated with smoking behaviors.	Norepinephrine	110-124	monoamine oxidase A	Homo sapiens	4-23
30456877-1	2019	The monoamine oxidase A (MAOA) enzyme metabolizes monoamine neurotransmitters such as dopamine, serotonin and norepinephrine, and its genetic polymorphism (rs1137070) influences its activity level and is associated with smoking behaviors.	Norepinephrine	110-124	monoamine oxidase A	Homo sapiens	25-29
31526440-0	2019	Effects of leptin on norepinephrine in acute ischemic stroke.	Norepinephrine	21-35	leptin	Homo sapiens	11-17
31526440-4	2019	Leptin administration increased noradrenaline concentration and dopamine beta-monooxygenase (DBH) but decreased noradrenaline transporter (NET) expression in primary cerebral neurons.	Norepinephrine	32-45	leptin	Homo sapiens	0-6
31526440-6	2019	JAK2 silencing also abolished the effects of leptin on noradrenaline metabolism.	Norepinephrine	55-68	leptin	Homo sapiens	45-51
31048375-8	2019	Treatment of brown adipocytes with MetAP2 inhibitors enhances norepinephrine-induced lipolysis and energy expenditure, and prolongs the activity of norepinephrine to increase ucp1 gene expression and energy expenditure in norepinephrine-desensitized brown adipocytes.	Norepinephrine	62-76	methionine aminopeptidase 2	Mus musculus	35-41
31048375-8	2019	Treatment of brown adipocytes with MetAP2 inhibitors enhances norepinephrine-induced lipolysis and energy expenditure, and prolongs the activity of norepinephrine to increase ucp1 gene expression and energy expenditure in norepinephrine-desensitized brown adipocytes.	Norepinephrine	148-162	methionine aminopeptidase 2	Mus musculus	35-41
31048375-8	2019	Treatment of brown adipocytes with MetAP2 inhibitors enhances norepinephrine-induced lipolysis and energy expenditure, and prolongs the activity of norepinephrine to increase ucp1 gene expression and energy expenditure in norepinephrine-desensitized brown adipocytes.	Norepinephrine	148-162	methionine aminopeptidase 2	Mus musculus	35-41
31190968-3	2019	Tapentadol, a centrally acting analgesic, is the first agent of a new class of drugs (MOR-NRI), since it combines two mechanisms of action, namely micro-opioid receptor (MOR) agonism and noradrenaline reuptake inhibition.	Norepinephrine	187-200	opioid receptor mu 1	Homo sapiens	86-89
6738296-4	1984	The work load immediately prior to the steep rise in plasma noradrenaline (sympathetic threshold level: STL) is considered to represent the point from which anaerobic energy-yielding processes play an increasingly greater role as the work load increases.	Norepinephrine	60-73	RNF217 antisense RNA 1 (head to head)	Homo sapiens	104-107
6738296-5	1984	The initial increase in plasma noradrenaline until STL was significantly higher in both the NTO (p less than 0.02) and BHO (p less than 0.005) compared to the control group.	Norepinephrine	31-44	RNF217 antisense RNA 1 (head to head)	Homo sapiens	51-54
6738296-6	1984	The absolute noradrenaline level at STL and the increase in noradrenaline from baseline to STL were significantly higher in the BHO group (p less than 0.02, p less than 0.005).	Norepinephrine	13-26	RNF217 antisense RNA 1 (head to head)	Homo sapiens	36-39
31367831-2	2019	In this study, we used a rat model that allowed blocking the synthesis of noradrenalin in the brain and evaluated gene expression and protein levels of noradrenaline key synthesis enzymes such as tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) in peripheral noradrenaline-producing organs.	Norepinephrine	152-165	dopamine beta-hydroxylase	Rattus norvegicus	226-251
31109396-2	2019	A specific high performance liquid chromatography-coulometric electrochemical detection method, for the assay of COMT activity was developed by measuring the formation of normetanephrine from norepinephrine.	Norepinephrine	192-206	catechol-O-methyltransferase	Rattus norvegicus	113-117
6428922-2	1984	Perfusion with ACh (100 nM-100 microM) produced dose-dependent vasodilatation of arteries preconstricted with norepinephrine and antagonized pressor responses to periarterial electrical stimulation.	Norepinephrine	110-124	acyl-CoA thioesterase 12	Rattus norvegicus	15-18
31109396-11	2019	The results confirmed the ability of entacapone to inhibit COMT activity by decreasing the production of all the metabolites of norepinephrine.	Norepinephrine	128-142	catechol-O-methyltransferase	Rattus norvegicus	59-63
6584029-4	1984	Similarly, in long-term (10-day) monolayer cultures of cells from four corpora lutea, human chorionic gonadotropin (hCG) (50 ng/ml) and PGE2 stimulated, but none of the adrenergic or cholinergic agents altered, the production of progesterone significantly, except for an inhibitory effect of norepinephrine and carbachol in the presence of 17 beta-estradiol (10(-7)M) added to the culture medium.	Norepinephrine	292-306	chorionic gonadotropin subunit beta 5	Homo sapiens	92-120
31019235-7	2019	Moreover, we revealed that plasma norepinephrine levels are elevated in SMA mice, which contributes to mechanical hypersensitivity via the beta2-adrenergic receptor.	Norepinephrine	34-48	adrenergic receptor, beta 2	Mus musculus	139-164
30971593-9	2019	There is a comparable increase in the SVR in both group, PVR showed a significant increase in the norepinephrine group compared to the terlipressin group (240.5 +- 23 vs. 140.6 +- 13 at skin closure than 190.3 +- 32 vs. 120.3 +- 10 at 24 h postoperatively).	Norepinephrine	98-112	PVR cell adhesion molecule	Homo sapiens	57-60
6371583-5	1984	Dopamine, noradrenaline, and adrenaline cells exhibited characteristic staining intensities to anti-aromatic L-amino acid decarboxylase reflective of relative enzyme levels in the different groups.	Norepinephrine	10-23	dopa decarboxylase	Rattus norvegicus	100-135
6319050-4	1984	In a novel technique designed to determine the specific activity of small quantities of tritiated S-adenosylmethionine, high performance liquid chromatography with electrochemical detection was used to measure the amount of adrenaline formed from unlabelled noradrenaline, in the presence of phenylethanolamine-N-methyltransferase and tritiated S-adenosylmethionine.	Norepinephrine	258-271	phenylethanolamine N-methyltransferase	Homo sapiens	292-330
30852703-4	2019	Finally, the density of monoamine oxidase-A (MAO-A), a mitochondrial enzyme that degrades 5-HT, norepinephrine, and dopamine (DA), was reported as lower in the OFC and ventral striatum of ASPD.	Norepinephrine	96-110	monoamine oxidase A	Homo sapiens	24-43
30852703-4	2019	Finally, the density of monoamine oxidase-A (MAO-A), a mitochondrial enzyme that degrades 5-HT, norepinephrine, and dopamine (DA), was reported as lower in the OFC and ventral striatum of ASPD.	Norepinephrine	96-110	monoamine oxidase A	Homo sapiens	45-50
30759385-0	2019	Age- and alpha-Synuclein-Dependent Degeneration of Dopamine and Noradrenaline Neurons in the Annual Killifish Nothobranchius furzeri.	Norepinephrine	64-77	synuclein alpha	Homo sapiens	9-24
29341465-7	2019	Moreover, loss of P2Y12 decreased the level of noradrenaline and the expression of noradrenergic alpha receptors, subtypes alpha2 (ARalpha2b) in mouse cerebellum and hippocampus.	Norepinephrine	47-60	purinergic receptor P2Y, G-protein coupled 12	Mus musculus	18-23
30429409-0	2019	Eukaryotic elongation factor 2 kinase inhibitor, A484954 inhibits noradrenaline-induced acute increase of blood pressure in rats.	Norepinephrine	66-79	eukaryotic elongation factor-2 kinase	Rattus norvegicus	0-37
31685777-8	2019	These observations demonstrate that enhanced GGT activity contributes to cardiac damage after myocardial ischemia/reperfusion, possibly via increased oxidative stress and subsequent norepinephrine overflow.	Norepinephrine	182-196	gamma-glutamyltransferase 1	Rattus norvegicus	45-48
30419287-1	2019	The human alpha1D-adrenergic receptor is a seven transmembrane-domain protein that mediates many of the physiological actions of adrenaline and noradrenaline and participates in the development of hypertension and benign prostatic hyperplasia.	Norepinephrine	144-157	adrenoceptor alpha 1D	Homo sapiens	10-37
30747098-5	2019	Corticotropin-releasing factor can be considered a fundamental biological element of resilience, which also involves neural mechanisms such as the hypothalamic-pituitary-adrenal (HPA) axis, the locus coeruleus/norepinephrine system, the mesolimbic reward circuit and the fear circuit.	Norepinephrine	210-224	corticotropin releasing hormone	Homo sapiens	0-30
6141712-6	1984	PNMT with norepinephrine as substrate was also significantly decreased in parkinsonian brains.	Norepinephrine	10-24	phenylethanolamine N-methyltransferase	Homo sapiens	0-4
6746191-5	1984	Significant decreases in systolic blood pressure, heart rate, plasma noradrenaline and urinary excretion of noradrenaline were observed in Gp I but not in Gp II.	Norepinephrine	69-82	glucose-6-phosphate isomerase	Homo sapiens	139-143
6746191-5	1984	Significant decreases in systolic blood pressure, heart rate, plasma noradrenaline and urinary excretion of noradrenaline were observed in Gp I but not in Gp II.	Norepinephrine	108-121	glucose-6-phosphate isomerase	Homo sapiens	139-143
31307617-2	2019	The pathology underlying this condition is thought to involve the deposition of alpha synuclein in the autonomic ganglia leading to diminished norepinephrine release and progressive autonomic dysfunction.	Norepinephrine	143-157	synuclein alpha	Homo sapiens	80-95
30341172-4	2018	Dopamine is converted to norepinephrine by dopamine-beta-hydroxylase (DBH), which acquires its essential Cu cofactor from ATP7A.	Norepinephrine	25-39	dopamine beta-hydroxylase	Homo sapiens	43-68
30341172-4	2018	Dopamine is converted to norepinephrine by dopamine-beta-hydroxylase (DBH), which acquires its essential Cu cofactor from ATP7A.	Norepinephrine	25-39	dopamine beta-hydroxylase	Homo sapiens	70-73
30551684-7	2018	Using biochemical assays, melatonin, norepinephrine, acetylcholine and serotonin levels in the brain were found to be significantly reduced in lepa KO fish, while the levels of dopamine, glycine and cortisol in the brain were significantly elevated.	Norepinephrine	37-51	leptin a	Danio rerio	143-147
6152777-4	1984	In contrast to their lack of effect in the Syrian hamster, norepinephrine and isoproterenol stimulated pineal serotonin N-acetyltransferase activity and melatonin content in the Djungarian hamster.	Norepinephrine	59-73	serotonin N-acetyltransferase	Mesocricetus auratus	110-139
6152777-5	1984	Hourly injection of norepinephrine during a continuation of light into the normal dark period stimulated increases in the activity of serotonin N-acetyltransferase and melatonin content in the Djungarian hamster but was without effect on these pineal parameters in the Syrian hamster.	Norepinephrine	20-34	serotonin N-acetyltransferase	Mesocricetus auratus	134-163
6235366-0	1984	Interactions of non-selective monoamine oxidase inhibitors, tranylcypromine and nialamide, with inhibitors of 5-hydroxytryptamine, dopamine or noradrenaline re-uptake.	Norepinephrine	143-156	monoamine oxidase A	Rattus norvegicus	30-47
30209240-5	2018	Both CNTF and secretagogin ablation occlude stress-induced cortical norepinephrine synthesis, ensuing neuronal excitation and behavioral stereotypes.	Norepinephrine	68-82	secretagogin, EF-hand calcium binding protein	Homo sapiens	14-26
30003648-4	2018	The mitochondrial enzyme monoamine oxidase-A (MAO-A) is a relevant source of ROS in the heart through the formation of H2 O2 derived from the degradation of its main substrates, norepinephrine (NE) and serotonin.	Norepinephrine	178-192	monoamine oxidase A	Homo sapiens	25-44
30003648-4	2018	The mitochondrial enzyme monoamine oxidase-A (MAO-A) is a relevant source of ROS in the heart through the formation of H2 O2 derived from the degradation of its main substrates, norepinephrine (NE) and serotonin.	Norepinephrine	178-192	monoamine oxidase A	Homo sapiens	46-51
30271325-1	2018	Monoamine oxidase A (MAO-A) is an enzyme that regulates the levels of monoamine neurotransmitters, such as serotonin, noradrenaline and dopamine and it has been used as a therapeutic target for depression.	Norepinephrine	118-131	monoamine oxidase A	Homo sapiens	0-19
6747915-0	1984	Interactions of a non-selective monoamine oxidase inhibitor, phenelzine, with inhibitors of 5-hydroxytryptamine, dopamine or noradrenaline re-uptake.	Norepinephrine	125-138	monoamine oxidase A	Rattus norvegicus	32-49
30271325-1	2018	Monoamine oxidase A (MAO-A) is an enzyme that regulates the levels of monoamine neurotransmitters, such as serotonin, noradrenaline and dopamine and it has been used as a therapeutic target for depression.	Norepinephrine	118-131	monoamine oxidase A	Homo sapiens	21-26
6323066-13	1983	Catecholamines are probably intimately involved in the generation of GnRH pulses--which for noradrenaline poses a paradox as all noradrenergic cell bodies lie outside the MBH.	Norepinephrine	92-105	gonadotropin releasing hormone 1	Homo sapiens	69-73
29751052-1	2018	This meta-analytical review examines whether a deletion variant in ADRA2B, a gene that encodes alpha2B adrenoceptor in the regulation of norepinephrine availability, influences cognitive processing of emotional information in human observers.	Norepinephrine	137-151	adrenoceptor alpha 2B	Homo sapiens	67-73
6645113-9	1983	It was concluded that an increase in MAO activity in SHR brain stem may trigger a reduction in noradrenaline content and that propranolol may be responsible for its restoration, thus reducing peripheral sympathetic activity; moreover, the increase in MAO activity in the hearts of SHR may be of genetic origin.	Norepinephrine	95-108	monoamine oxidase A	Rattus norvegicus	37-40
6317123-6	1983	This response appeared to be mediated by both beta 1- and beta 2-adrenoceptors in tracheal spirals as the pA2 value for the beta 1-selective antagonist, atenolol, varied depending upon which agonist was used, and, in the presence of the beta 2-adrenoceptor antagonist ICI 118,551, noradrenaline and isoprenaline produced biphasic concentration-effect curves.	Norepinephrine	281-294	beta-2 adrenergic receptor	Cavia porcellus	58-77
29739827-9	2018	Finally, renal nerve dysfunction in Uchl1-/- mice is suggested given increased renal nerve arborization, decreased urinary norepinephrine, and impaired vascular reactivity.	Norepinephrine	123-137	ubiquitin C-terminal hydrolase L1	Homo sapiens	36-41
6413344-3	1983	Insulin and noradrenaline stimulated TRH release from frog skin in a dose-related manner.	Norepinephrine	12-25	thyrotropin releasing hormone	Homo sapiens	37-40
28760662-8	2018	Intriguingly, in vivo EtOH exposure (4g/kg IP) enhanced c-FOS colocalization with tyrosine hydroxylase via immunohistochemical methods, indicating that NTS norepinephrine neurons may be activated by acute EtOH exposure.	Norepinephrine	156-170	FBJ osteosarcoma oncogene	Mus musculus	56-61
6652339-0	1983	In vivo, noradrenaline is a substrate for rat brain monoamine oxidase A and B.	Norepinephrine	9-22	monoamine oxidase A	Rattus norvegicus	52-77
6652339-1	1983	In vivo clorgyline (5 mg/kg) and (-)-deprenyl (5 mg/kg) selectively inhibit monoamine oxidase (MAO) type A and B activities in rat brain hypothalamus and caudate nucleus using 5-hydroxytryptamine (5-HT), noradrenaline (NA), and beta-phenylethylamine (PEA) as substrates.	Norepinephrine	204-217	monoamine oxidase A	Rattus norvegicus	76-112
6300893-8	1983	Addition of norepinephrine (10 microM) led to increases in burst frequency and beta-endorphin secretion mediated by activation of beta-adrenergic receptors.	Norepinephrine	12-26	pro-opiomelanocortin-alpha	Mus musculus	79-93
29485127-0	2018	Norepinephrine Inhibits Th17 Cells via beta2-Adrenergic Receptor (beta2-AR) Signaling in a Mouse Model of Rheumatoid Arthritis.	Norepinephrine	0-14	adrenergic receptor, beta 2	Mus musculus	39-64
6299476-0	1983	Regulation of choline acetyltransferase in primary cell cultures of spinal cord by neurotransmitter L-norepinephrine.	Norepinephrine	100-116	choline acetyltransferase	Mus musculus	14-39
6299476-1	1983	Neurotransmitter L-norepinephrine increased up to 8-fold the activity of choline acetyltransferase (CAT), the enzyme responsible for the synthesis of acetylcholine, in mouse spinal cord cells in culture grown for several days.	Norepinephrine	17-33	choline acetyltransferase	Mus musculus	73-98
6299476-1	1983	Neurotransmitter L-norepinephrine increased up to 8-fold the activity of choline acetyltransferase (CAT), the enzyme responsible for the synthesis of acetylcholine, in mouse spinal cord cells in culture grown for several days.	Norepinephrine	17-33	choline acetyltransferase	Mus musculus	100-103
6299476-2	1983	The increase of CAT activity by L-norepinephrine was mediated by a beta-adrenergic receptor in the same manner as the response of intracellular cyclic AMP.	Norepinephrine	32-48	choline acetyltransferase	Mus musculus	16-19
29485127-0	2018	Norepinephrine Inhibits Th17 Cells via beta2-Adrenergic Receptor (beta2-AR) Signaling in a Mouse Model of Rheumatoid Arthritis.	Norepinephrine	0-14	adrenergic receptor, beta 2	Mus musculus	66-74
6826683-0	1983	Sensitive and specific radioenzymatic assay for norepinephrine, epinephrine and dopamine based on the thin-layer chromatographic separation of their Dns-O-methyl derivatives.	Norepinephrine	48-62	dysplastic nevus syndrome	Homo sapiens	149-152
6826683-1	1983	A radioenzymatic assay is described in which norepinephrine, epinephrine and dopamine are converted to their tritiated 3-O-methyl derivatives by reaction with S-[methyl-3H]adenosyl-L-methionine in the presence of catechol-O-methyltransferase.	Norepinephrine	45-59	catechol-O-methyltransferase	Homo sapiens	213-241
29456827-9	2018	Moreover, neurotransmitters including serotonin, norepinephrine, and dopamine were significantly increased in different brain regions of the Arhgef10 knockout mice.	Norepinephrine	49-63	Rho guanine nucleotide exchange factor (GEF) 10	Mus musculus	141-149
6301307-4	1983	Beta 1- and beta 2-responses were expressed as the increments of cyclic AMP content of 10(6) lymphocytes incubated with norepinephrine (beta 1-stimulant) and salbutamol (beta 2-stimulant).	Norepinephrine	120-134	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	12-18
6196020-2	1983	Monoamine-oxidase (MAO) activity was detected in rat pineal gland with dopamine, 5-hydroxytryptamine (5-HT), norepinephrine and tryptamine as substrates, and nitroblue tetrazolium salt as electron acceptor.	Norepinephrine	109-123	monoamine oxidase A	Rattus norvegicus	0-17
6196020-2	1983	Monoamine-oxidase (MAO) activity was detected in rat pineal gland with dopamine, 5-hydroxytryptamine (5-HT), norepinephrine and tryptamine as substrates, and nitroblue tetrazolium salt as electron acceptor.	Norepinephrine	109-123	monoamine oxidase A	Rattus norvegicus	19-22
29247240-3	2017	Using genetic and RNA interference approaches, we show that the activity of the Oamb gene, which encodes a receptor for octopamine (OA, the invertebrate homologue of norepinephrine), plays a major role in controlled sugar consumption.	Norepinephrine	166-180	Octopamine receptor in mushroom bodies	Drosophila melanogaster	80-84
6138754-1	1983	It has been found that ATP-ase activity increases considerably in the heart after intravenous administration of adrenaline, noradrenaline, phenylephrine (50 micrograms/kg), phentolamine, atropine, and also after vagotomy and adrenaline given after vagotomy.	Norepinephrine	124-137	dynein axonemal heavy chain 8	Homo sapiens	23-30
6138754-2	1983	In the skeletal muscle ATP-ase activity increases considerably after noradrenaline, isoprenaline, phenylephrine (50 micrograms/kg), adrenaline given after phentolanine and Ach given after denervation of the muscle.	Norepinephrine	69-82	dynein axonemal heavy chain 8	Homo sapiens	23-30
6763912-0	1982	Renal denervation in rats: effects of intravenous infusions of norepinephrine on plasma renin activity &amp; renal excretory functions.	Norepinephrine	63-77	renin	Rattus norvegicus	88-93
6762615-1	1982	The relationship between renin secretion and PGI2 production, in response to intrarenal infusion of norepinephrine, was examined in the isolated perfused rat kidney.	Norepinephrine	100-114	renin	Rattus norvegicus	25-30
6762615-2	1982	Infusion of norepinephrine in a dose which caused substantial vasoconstriction (100 ng/min), markedly increased urinary excretion of 6-keto PGF1 alpha, the stable derivative of PGI2, without significantly altering renin secretion measured in the effluent perfusate.	Norepinephrine	12-26	renin	Rattus norvegicus	214-219
6762615-6	1982	These findings clearly indicate that in the rat kidney prostacyclin production and renin release in response to norepinephrine are dissociated.	Norepinephrine	112-126	renin	Rattus norvegicus	83-88
7163642-3	1982	MAO inhibitors and reserpine blocked norepinephrine stimulation but uptake inhibition did not.	Norepinephrine	37-51	monoamine oxidase A	Rattus norvegicus	0-3
7163642-4	1982	These data demonstrate that, under the tested conditions, MAO mediated norepinephrine metabolism does stimulate shunt activity but not at physiological concentrations.	Norepinephrine	71-85	monoamine oxidase A	Rattus norvegicus	58-61
6127586-2	1982	The beta-adrenoceptors had some of the characteristics of mammalian beta 2-adrenoceptors in that (i) adrenaline was more potent than noradrenaline and (ii) the pA2 values of two selection beta-adrenoceptor antagonists, atenolol (pA2 = 5.84) and alpha-methylpropranolol (pA2 = 8.42), were close to the values reported on beta 2-adrenoceptors in mammalian tissues.	Norepinephrine	133-146	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	68-74
6806317-2	1982	When CNS stores of norepinephrine (NE) were selectively reduced by the subcutaneous administration of the dopamine-beta-hydroxylase inhibitor FLA-63, TRH concentrations were significantly reduced throughout the brain.	Norepinephrine	19-33	thyrotropin releasing hormone	Rattus norvegicus	150-153
6126864-3	1982	Release of LHRH, somatostatin and vasopressin is affected by a variety of neurotransmitters or neuromodulators, such as norepinephrine, dopamine, epinephrine, histamine, cholinergic and opioid agonists, and peptides such as angiotensin II.	Norepinephrine	120-134	gonadotropin releasing hormone 1	Homo sapiens	11-15
6175369-5	1982	2 In a separate group of animals, noradrenaline infusion in this manner and at similar dose rate increased plasma renin activity approximately 3 fold.	Norepinephrine	34-47	renin	Rattus norvegicus	114-119
6175369-10	1982	5 These data show that the regulation of glomerular filtration rate in response to the vasoconstrictor drug, noradrenaline, is partly mediated via the renin-angiotensin system.	Norepinephrine	109-122	renin	Rattus norvegicus	151-156
6279209-0	1982	[Activation of citrate synthase of liver mitochondria by norepinephrine and cyclic AMP].	Norepinephrine	57-71	citrate synthase	Homo sapiens	15-31
6133950-12	1982	The stimulation of membrane ATPase (by switching off K and its readmission) results in an inhibition of both ACh and noradrenaline release evoked by axonal stimulation.	Norepinephrine	117-130	dynein, axonemal, heavy chain 8	Mus musculus	28-34
6794869-4	1981	The correlation existing between dihydrotetrabenazine site occupancy and noradrenaline uptake inhibition indicates that these sites are located on the monoamine transporter.	Norepinephrine	73-86	solute carrier family 18 member A2	Homo sapiens	151-172
6166354-1	1981	Mice treated with D,L-alpha-monofluoromethyl-dopa (MFMD, RMI 71963), an irreversible inhibitor of aromatic L-amino acid decarboxylase (AADC), showed marked decrease in whole-brain concentrations of norepinephrine, dopamine and serotonin.	Norepinephrine	198-212	dopa decarboxylase	Mus musculus	107-133
6166354-1	1981	Mice treated with D,L-alpha-monofluoromethyl-dopa (MFMD, RMI 71963), an irreversible inhibitor of aromatic L-amino acid decarboxylase (AADC), showed marked decrease in whole-brain concentrations of norepinephrine, dopamine and serotonin.	Norepinephrine	198-212	dopa decarboxylase	Mus musculus	135-139
6125573-2	1981	The decrease in norepinephrine levels was accompanied by a decrease in the activity of the rate-limiting biosynthetic enzyme, tyrosine hydroxylase.	Norepinephrine	16-30	tyrosine hydroxylase	Rattus norvegicus	126-146
6125573-3	1981	However, the decrease in enzyme activity was less pronounced than the decrease in norepinephrine levels, resulting in an increase in the ratio of tyrosine hydroxylase activity to norepinephrine content.	Norepinephrine	82-96	tyrosine hydroxylase	Rattus norvegicus	146-166
6260644-4	1981	These cells responded to epinephrine and norepinephrine by increasing both synthesis and release of renin.	Norepinephrine	41-55	renin	Rattus norvegicus	100-105
7004860-7	1981	Microinjections of epinephrine and norepinephrine into the VMH also caused rises in the levels of both glucagon and insulin, although the effects of norepinephrine were much less than those of epinephrine.	Norepinephrine	35-49	insulin	Oryctolagus cuniculus	116-123
7001180-0	1980	Acute effects of insulin on plasma noradrenaline and the cardiovascular system.	Norepinephrine	35-48	insulin	Oryctolagus cuniculus	17-24
7001180-1	1980	It is now known that insulin has marked acute effects on plasma noradrenaline and the cardiovascular system.	Norepinephrine	64-77	insulin	Oryctolagus cuniculus	21-28
7001180-3	1980	Intravenous injection of insulin in juvenile diabetics increased plasma noradrenaline and heart rate and decreased glomerular filtration rate, renal and peripheral blood flow, and plasma volume.	Norepinephrine	72-85	insulin	Oryctolagus cuniculus	25-32
7001180-12	1980	The mechanism of action of insulin on plasma noradrenaline, heart rate, plasma volume, and urinary albumin excretion is not known.	Norepinephrine	45-58	insulin	Oryctolagus cuniculus	27-34
7001180-13	1980	The rise in plasma noradrenaline after insulin may be compensatory to hypovolemia or to antagonizing effects of insulin on some actions of noradrenaline.	Norepinephrine	19-32	insulin	Oryctolagus cuniculus	39-46
7001180-13	1980	The rise in plasma noradrenaline after insulin may be compensatory to hypovolemia or to antagonizing effects of insulin on some actions of noradrenaline.	Norepinephrine	19-32	insulin	Oryctolagus cuniculus	112-119
7001180-13	1980	The rise in plasma noradrenaline after insulin may be compensatory to hypovolemia or to antagonizing effects of insulin on some actions of noradrenaline.	Norepinephrine	139-152	insulin	Oryctolagus cuniculus	39-46
7001180-13	1980	The rise in plasma noradrenaline after insulin may be compensatory to hypovolemia or to antagonizing effects of insulin on some actions of noradrenaline.	Norepinephrine	139-152	insulin	Oryctolagus cuniculus	112-119
7470592-5	1980	The level of plasma norepinephrine in healthy subjects at recumbency was 297 +/- 95 pg ml-1 (mean +/- SD).	Norepinephrine	20-34	interleukin 17F	Homo sapiens	87-91
7470592-6	1980	The lower limit of sensitivity was 25 pg ml-1 of norepinephrine in plasma.	Norepinephrine	49-63	interleukin 17F	Homo sapiens	41-45
6931118-1	1980	The secretion of N-acetyl-beta-glucosaminidase of mouse submaxillary gland into saliva was stimulated by norepinephrine and phenylephrine but not by pilocarpine and isoproterenol.	Norepinephrine	105-119	O-GlcNAcase	Mus musculus	17-46
6105122-2	1980	Isoproterenol was the most potent and norepinephrine the least potent of the three stimuli, suggesting a beta 2 type of an adrenergic response.	Norepinephrine	38-52	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	105-111
7000971-2	1980	The assay consists basically of 1. conversion of epinephrine, norepinephrine, and dopamine into their respective methyl-derivates in the presence of catechol-O-methyltransferase and S-adenosylmethionine-[3H]methyl, 2. extraction of the methylated 3H labelled amines with diethyl ether, 3. separation by thin-layer chromatography, 4. measurement in a beta radiation scintillation counter.	Norepinephrine	62-76	catechol-O-methyltransferase	Homo sapiens	149-177
6998806-1	1980	The purpose of this study was to determine if increased concentrations of pancreatic islet norepinephrine, dopamine, or serotonin after insulin secretion.	Norepinephrine	91-105	insulin	Mesocricetus auratus	136-143
7192903-1	1980	Monoamine oxidase (MAO) activity was studied in hyporthalamus, midbrain, brain stem and liver tissue of rats after single and repeated administration of ethanol using noradrenaline and dopamine as MAO substrates.	Norepinephrine	167-180	monoamine oxidase A	Rattus norvegicus	19-22
6776573-5	1980	These data, along with the findings that MK-771 and TRH enhance depletion of brain norepinephrine induced by alpha-methyl-p-tyrosine, indicate that these agents may affect central noradrenergic mechanisms.	Norepinephrine	83-97	thyrotropin releasing hormone	Rattus norvegicus	52-55
44425-3	1979	Intravenous infusion of noradrenaline or adrenaline markedly reduced rCBF (by 22-48% of control levels) in all regions except thalamus, mesencephalon, and pons.	Norepinephrine	24-37	CCAAT/enhancer binding protein zeta	Rattus norvegicus	69-73
459155-1	1979	Effects of intraventricularly administered serotonin (5HT), noradrenaline (NA), dopamine (DA) and metaraminol on the reserpine-induced spikes recorded from the medial nucleus Trapezoides (Trap.	Norepinephrine	60-73	tartrate-resistant acid phosphatase type 5	Oryctolagus cuniculus	175-179
17955643-3	1979	It is concluded that desoxycorticosterone potentiates the effects of noradrenaline by inhibiting its inactivation by Catechol-O-methyltransferase.	Norepinephrine	69-82	catechol-O-methyltransferase	Homo sapiens	117-145
709862-1	1978	We have developed a radioenzymatic method for the estimation of noradrenalin in small plasma samples by utilizing partly purified phenylethanolamine-N-methyltransferase.	Norepinephrine	64-76	phenylethanolamine N-methyltransferase	Homo sapiens	130-168
580532-7	1978	Adrenaline and noradrenaline reduce significantly the secretion HCS by full term placentas and have no action on HCG secretion.	Norepinephrine	15-28	holocarboxylase synthetase	Homo sapiens	64-67
348542-6	1978	Perfusion of the isolated pancreas of the diabetic rats pretreated with IAP showed an increase in insulin response to glucose and loss of suppression of glucagon secretion by noradrenaline.	Norepinephrine	175-188	Cd47 molecule	Rattus norvegicus	72-75
100063-0	1978	[Action of TRH on the capture and storage of noradrenaline by the isolated ductus deferens of the rat].	Norepinephrine	45-58	thyrotropin releasing hormone	Rattus norvegicus	11-14
207081-5	1978	Arterial blood pressure rise after intraventricular administration of noradrenaline is caused by activation of the renin-angiotensin system in the periphery.	Norepinephrine	70-83	renin	Rattus norvegicus	115-120
579535-0	1978	Effect of the depletion on brain noradrenaline on the plasma FSH and growth hormone levels in ovariectomized rats.	Norepinephrine	33-46	gonadotropin releasing hormone receptor	Rattus norvegicus	69-83
921400-0	1977	Influence of MAO inhibitors on uptake and release of norepinephrine in rat brain in vitro.	Norepinephrine	53-67	monoamine oxidase A	Rattus norvegicus	13-16
19604975-1	1977	Evidence for discrete changes in dopamine and noradrenaline turnover following growth hormone administration.	Norepinephrine	46-59	gonadotropin releasing hormone receptor	Rattus norvegicus	79-93
18744-3	1977	These results suggest that the enhanced brain norepinephrine turnover reported to occur after treatment with TRH is not due to synthesis of new TH enzyme protein.	Norepinephrine	46-60	thyrotropin releasing hormone	Rattus norvegicus	109-112
918143-1	1977	This work reports the effects of acute and chronic administration of L-dopa and ethanol + L-dopa on MAO activity in rat brain stem and cerebral cortex using noradrenaline (NA), dopamine (DA), serotonin (5-HT) and tryptamine (Try) as substrates.	Norepinephrine	157-170	monoamine oxidase A	Rattus norvegicus	100-103
136359-2	1976	Dopamine and norepinephrine added in vitro showed a dose-dependent stimulation of Na+ and K+ activated and oligomycin sensitive Mg2+ ATPase activities in brain but not kidney and liver tissue fractions.	Norepinephrine	13-27	dynein, axonemal, heavy chain 8	Mus musculus	133-139
12423-4	1976	Principally, TH was present in neuron systems with a distribution similar to known dopamine, noradrenaline and adrenaline systems.	Norepinephrine	93-106	tyrosine hydroxylase	Rattus norvegicus	13-15
5851-0	1976	Beta2-adrenoceptors facilitating noradrenaline secretion from human vasoconstrictor nerves.	Norepinephrine	33-46	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	0-5
938990-0	1976	The renin-angiotensin system, dietary salt, and increased sensitivity to noradrenaline in mesenteric vasculature preparations from renal/salt hypertensive rats.	Norepinephrine	73-86	renin	Rattus norvegicus	4-9
938990-2	1976	The noradrenaline supersensitivity of tissues from renal/salt hypertensive rats, with low plasma renin activity, is not caused by endogenous angiotensin II since it was unaffected by Sar1 Ileu8 angiotensin II.	Norepinephrine	4-17	renin	Rattus norvegicus	97-102
172259-3	1976	The potentiation of vasoconstrictor responses to sympathetic nerve stimulation and injected norepinephrine which was elicited by renin substrate and angiotensin I was abolished by an inhibitor of angiotensin I-converting enzyme, SQ 20,881, and by an angiotensin II receptor antagonist, [Sar1-Ile8]angiotensin II.	Norepinephrine	92-106	renin	Rattus norvegicus	129-134
1250856-0	1976	The effect of age and norepinephrine on renin release by rat kidney slices in vitro.	Norepinephrine	22-36	renin	Rattus norvegicus	40-45
1250856-4	1976	However, the ability of renin release to respond to stimuli, such as norepinephrine, is enhanced at the time of declining basal renin release and developing hypertension.	Norepinephrine	69-83	renin	Rattus norvegicus	24-29
1250856-4	1976	However, the ability of renin release to respond to stimuli, such as norepinephrine, is enhanced at the time of declining basal renin release and developing hypertension.	Norepinephrine	69-83	renin	Rattus norvegicus	128-133
1204291-0	1975	The stimulation of renin secretion by non-vasocontrictor infusions of adrenaline and noradrenaline in the isolated rat kidney.	Norepinephrine	85-98	renin	Rattus norvegicus	19-24
1204291-4	1975	Under these conditions adrenaline and noradrenaline significantly increased renin secretion rates, compared with control experiments in which no catecholamine was infused.	Norepinephrine	38-51	renin	Rattus norvegicus	76-81
1241962-4	1975	Clorgyline inhibited the formation of HVA, DOPAC and MOPEG with an ED50 of about 0.2 mg/kg s.c. and l-deprenyldopamine and noradrenaline are formed by the same type of monoamine oxidase(s), probably type A, in the rat brain in vivo.	Norepinephrine	123-136	monoamine oxidase A	Rattus norvegicus	168-185
1153625-13	1975	The smaller increase of brain noradrenaline (NA) after Tc and RbCl suggests that a lower percentage of NA is being metabolised by MAO.	Norepinephrine	30-43	monoamine oxidase A	Rattus norvegicus	130-133
812145-0	1975	Interactions of the tripeptide pyroglutamyl-histidyl-proline amide (thyrotropin-releasing hormone) with brain norepinephrine metabolism: evidence for an extrahypophyseal action of TRH on central nervous system function.	Norepinephrine	110-124	thyrotropin releasing hormone	Homo sapiens	68-97
4458861-0	1974	Proceedings: The effect of delta-1-tetrahydrocannabinol on the noradrenaline and dopamine content of the brain and heart of the rat.	Norepinephrine	63-76	delta like canonical Notch ligand 1	Rattus norvegicus	27-34
4207412-0	1974	Enhancement of cerebral noradrenaline turnover by thyrotropin-releasing hormone.	Norepinephrine	24-37	thyrotropin releasing hormone	Homo sapiens	50-79
4276583-0	1974	Proceedings: Thyrotropin-releasing hormone: activation of cerebral noradrenaline turnover.	Norepinephrine	67-80	thyrotropin releasing hormone	Homo sapiens	13-42
4405624-3	1973	Evidence is presented that additionally the antibiotics inhibit the activity of tyrosine hydroxylase, a finding that suggests that their amnestic effect may be due in part to reduction of the functional pool of norepinephrine.	Norepinephrine	211-225	tyrosine hydroxylase	Rattus norvegicus	80-100
4117772-1	1972	The transport of norepinephrine and two key enzymes involved in its synthesis, tyrosine hydroxylase (EC 1.14.3a) and dopamine beta-hydroxylase (EC 1.14.2.1), has been studied in relation to other axonal constituents in ligated chicken sciatic nerves.	Norepinephrine	17-31	tyrosine hydroxylase	Gallus gallus	79-99
5061245-2	1972	A single intraventricular injection of nerve growth factor, given at the time of axonal damage, resulted in an increased formation and growth of new noradrenaline sprouts 7 days later.	Norepinephrine	149-162	nerve growth factor	Rattus norvegicus	39-58
4961855-0	1967	[Effect of sodium nitrate and nitroglycerine on incorporation of P-32 into energetic phosphates in the heart--antagonism to noradrenaline].	Norepinephrine	124-137	inhibitor of growth family member 2	Homo sapiens	65-69
28593564-3	2017	In this study, we treated H9c2 cardiac myoblasts with norepinephrine (NE, 2 microM), inducing ROS generation that was inhibited by Nox2-specific peptide inhibitor gp91ds-tat.	Norepinephrine	54-68	cytochrome b-245 beta chain	Homo sapiens	131-135
6031982-0	1967	[Comparison of the action of noradrenaline and adrenaline on the metabolism of energetic phosphates in the heart by the use of P32].	Norepinephrine	29-42	inhibitor of growth family member 2	Homo sapiens	127-130
13882415-0	1961	Effect of inhibiting both catechol-O-methyl transferase and monoamine oxidase on cardiovascular responses to norepinephrine.	Norepinephrine	109-123	catechol-O-methyltransferase	Homo sapiens	26-55
14442503-1	1960	Histidine decarboxylase activity of mouse tissues is increased by stress and by injection of epinephrine and norepinephrine, suggesting a balance between histamine and catechol amines producing a component of circulatory homeostasis.	Norepinephrine	109-123	histidine decarboxylase	Mus musculus	0-23
33677066-11	2021	beta1-AR were stimulated with the physiological agonist norepinephrine (100 muM).	Norepinephrine	56-70	adrenoceptor beta 1	Homo sapiens	0-8
33550481-12	2021	Modulation in cortical levels of histamine, norepinephrine and dopamine provides the neurochemical basis for wake-promoting and anticataplectic effects observed in orexin knockout mice.	Norepinephrine	44-58	hypocretin	Mus musculus	164-170
33093660-0	2021	Binding pathway determines norepinephrine selectivity for the human beta1AR over beta2AR.	Norepinephrine	27-41	adrenoceptor beta 1	Homo sapiens	68-75
33093660-2	2021	While the hormone epinephrine binds beta1AR and beta2AR with similar affinity, the smaller neurotransmitter norepinephrine is approximately tenfold selective for the beta1AR.	Norepinephrine	108-122	adrenoceptor beta 1	Homo sapiens	166-173
33722543-10	2021	Our results suggest that both extracellular dopamine and norepinephrine homeostasis could be regulated by ErbB4 in human catecholaminergic cells, and ErbB4 may regulate extracellular dopamine, but not norepinephrine, through the p38 MAPK signaling pathway, thus indicating different regulatory pathways of dopamine and norepinephrine by ErbB4 in catecholaminergic neurons.	Norepinephrine	57-71	erb-b2 receptor tyrosine kinase 4	Homo sapiens	106-111
33854153-7	2021	Immunohistochemically P75NTR protein level changes after DEX were investigated in the brainstem Locus Coereleus norepinephrine neurons (NE).	Norepinephrine	112-126	nerve growth factor receptor	Rattus norvegicus	22-28
29472953-1	2017	Objective: Several studies have shown that some polymorphisms of genes encoding catechol-O-methyltransferase (COMT), the key enzyme in degrading dopamine, and norepinephrine and the human brain-derived neurotropic factor (BDNF), a nerve growth factor, are strong candidates for risk of schizophrenia (SCZ).	Norepinephrine	159-173	brain derived neurotrophic factor	Homo sapiens	222-226
28663279-1	2017	The alpha-like octopamine receptors (OctR) are believed to be the evolutionary precursor to the vertebrate alpha2-adrenergic receptors (alpha2-ARs) based upon sequence similarity and the ability to interact with norepinephrine and a number of compounds that bind with high affinity to alpha2-ARs.	Norepinephrine	212-226	nicotinic Acetylcholine Receptor alpha1	Drosophila melanogaster	4-14
28472693-8	2017	In the CRH group, the total increase of sAA activity significantly correlated with noradrenaline release, indicating that sAA activity reflects pharmacologically induced sympathetic activation.	Norepinephrine	83-96	amylase alpha 1A	Homo sapiens	122-125
33833669-4	2021	Our results show that application of norepinephrine leads to a cytosolic calcium rise in astrocytes which is independent of neuronal activity and mainly mediated by PLC/IP3-dependent internal calcium release.	Norepinephrine	37-51	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	165-168
33691909-1	2021	Cold-induced norepinephrine activates beta3-adrenergic receptors (beta3-AR) to stimulate the kinase cascade and cAMP-response element-binding protein, leading to the induction of thermogenic gene expression including uncoupling protein 1 (Ucp1).	Norepinephrine	13-27	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	217-237
33691909-1	2021	Cold-induced norepinephrine activates beta3-adrenergic receptors (beta3-AR) to stimulate the kinase cascade and cAMP-response element-binding protein, leading to the induction of thermogenic gene expression including uncoupling protein 1 (Ucp1).	Norepinephrine	13-27	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	239-243
33691777-1	2021	OBJECTIVE: Lymphocytes express tyrosine hydroxylase (TH), the rate-limiting enzyme for the synthesis of dopamine, norepinephrine and epinephrine.	Norepinephrine	114-128	tyrosine hydroxylase	Mus musculus	31-51
33481407-16	2021	CONCLUSIONS: Our findings demonstrate that treatment with epinephrine or norepinephrine strongly reduces endothelial permeability induced by agonists of multiple Toll-like receptors (Toll-like receptor-2, Toll-like receptor-3, Toll-like receptor-4) in vitro.	Norepinephrine	73-87	toll like receptor 3	Homo sapiens	205-225
33368026-1	2021	BACKGROUND AND OBJECTIVES: Viloxazine extended-release (viloxazine ER, SPN-812) is a novel non-stimulant with activity at serotonin receptors and the norepinephrine transporter, which is under investigation as a potential treatment for attention-deficit/hyperactivity disorder.	Norepinephrine	150-164	epiregulin	Homo sapiens	67-69
28458039-1	2017	Dexamethaone (DEX, glucocorticoid receptor agonist) and RU486 (glucocorticoid receptor inhibitor) may affect the behavior of attention deficit hyperactivity disorder (ADHD) rats, by changing the level of dopamine and noradrenaline and dopamine transporter in different regions of their brain.	Norepinephrine	217-230	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	19-42
32246947-11	2020	There was a positive correlation between noradrenaline release and formation of C1P and/or CerK-HA levels in NGF- and clasto-lactacystin-treated cells.	Norepinephrine	41-54	nerve growth factor	Rattus norvegicus	109-112
32356961-3	2020	Here, we found that the isomers of MCAT are nearly equieffective at dopamine and norepinephrine transporters (DAT and NET, respectively) as transporter substrates (i.e., as releasing agents), and are >63-fold less potent at the serotonin transporter (SERT).	Norepinephrine	81-95	solute carrier family 6 member 3	Rattus norvegicus	110-113
32269106-5	2020	In the present study we investigate the potential for matrix metalloprotease-9 (MMP-9), an endopeptidase secreted in response to neuronal activity, to contribute to the antidepressant efficacy of the serotonin/norepinephrine reuptake inhibitor venlafaxine in male mice.	Norepinephrine	210-224	matrix metallopeptidase 9	Mus musculus	54-78
32269106-5	2020	In the present study we investigate the potential for matrix metalloprotease-9 (MMP-9), an endopeptidase secreted in response to neuronal activity, to contribute to the antidepressant efficacy of the serotonin/norepinephrine reuptake inhibitor venlafaxine in male mice.	Norepinephrine	210-224	matrix metallopeptidase 9	Mus musculus	80-85
32303636-3	2020	Here, we analyzed the correlation between ligand binding and receptor conformation of the alpha1A-adrenoceptor, a GPCR that stimulates smooth muscle contraction in response to binding noradrenaline.	Norepinephrine	184-197	adrenoceptor alpha 1A	Homo sapiens	90-110
32281745-2	2020	This study investigates the effect of chronic administration of the serotonin-norepinephrine reuptake inhibitor, venlafaxine, on the expression and methylation status of SOD1, SOD2, GPx1, GPx4, CAT, NOS1 and NOS2 in the brain and blood of rats exposed to a chronic mild stress (CMS) model of depression.	Norepinephrine	78-92	glutathione peroxidase 4	Rattus norvegicus	188-192
32006557-8	2020	In addition, IF1 treatment showed sympathetic nerve activation as measured by serum norepinephrine levels and UCP-1 expression in the subcutaneous fat of HFD-fed male mice.	Norepinephrine	84-98	ATP synthase inhibitory factor subunit 1	Homo sapiens	13-16
31955266-7	2020	The AGE-BSA-mediated suppression of noradrenaline-induced contraction was prevented by the organic cation transporter 3 (OCT3) inhibitor corticosterone, whereas the expression of OCT3 protein was similar between control and AGE-BSA-treated endothelium-denuded carotid arteries.	Norepinephrine	36-49	solute carrier family 22 member 3	Rattus norvegicus	91-119
31955266-7	2020	The AGE-BSA-mediated suppression of noradrenaline-induced contraction was prevented by the organic cation transporter 3 (OCT3) inhibitor corticosterone, whereas the expression of OCT3 protein was similar between control and AGE-BSA-treated endothelium-denuded carotid arteries.	Norepinephrine	36-49	solute carrier family 22 member 3	Rattus norvegicus	121-125
31955266-8	2020	These findings suggest that noradrenaline-induced arterial contraction is reduced by prolonged AGE-BSA exposure due to activation of BKCa channels via H2O2 generation and increased OCT3-mediated noradrenaline transport activity.	Norepinephrine	28-41	solute carrier family 22 member 3	Rattus norvegicus	181-185
31955266-8	2020	These findings suggest that noradrenaline-induced arterial contraction is reduced by prolonged AGE-BSA exposure due to activation of BKCa channels via H2O2 generation and increased OCT3-mediated noradrenaline transport activity.	Norepinephrine	195-208	solute carrier family 22 member 3	Rattus norvegicus	181-185
32104529-0	2020	Norepinephrine Induces Lung Microvascular Endothelial Cell Death by NADPH Oxidase-Dependent Activation of Caspase-3.	Norepinephrine	0-14	caspase 3	Rattus norvegicus	106-115
31810852-7	2020	The Molecular Docking and afterward Molecular Dynamics calculations of formed complexes between octopamine/norepinephrine with beta1- and beta2- adrenergic receptors examined in details the interactions that lead to the formation of stable complexes.	Norepinephrine	107-121	adrenoceptor beta 1	Homo sapiens	127-165
28458039-1	2017	Dexamethaone (DEX, glucocorticoid receptor agonist) and RU486 (glucocorticoid receptor inhibitor) may affect the behavior of attention deficit hyperactivity disorder (ADHD) rats, by changing the level of dopamine and noradrenaline and dopamine transporter in different regions of their brain.	Norepinephrine	217-230	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	63-86
28116771-13	2017	Tensions following combined application of endothelin-2 or -3 with U46619 stayed below noradrenaline-induced contractions.	Norepinephrine	87-100	endothelin 2	Homo sapiens	43-55
28100476-10	2017	These findings indicate a functional islet defect in anemic fetuses, which likely involves direct effects of low oxygen and/or increased norepinephrine on insulin release.	Norepinephrine	137-151	LOC105613195	Ovis aries	155-162
31771069-3	2020	Catechol-O-methyltransferase (COMT) and monoamine oxidase B (MAOB) are the enzymes that regulate degradation of dopamine, while dopamine beta-hydroxylase (DBH) is involved in synthesis of noradrenaline.	Norepinephrine	188-201	catechol-O-methyltransferase	Homo sapiens	0-28
31771069-3	2020	Catechol-O-methyltransferase (COMT) and monoamine oxidase B (MAOB) are the enzymes that regulate degradation of dopamine, while dopamine beta-hydroxylase (DBH) is involved in synthesis of noradrenaline.	Norepinephrine	188-201	catechol-O-methyltransferase	Homo sapiens	30-34
32378629-4	2020	It has been suggested that the extracellular noradrenaline (NA) level is increased by stress in the laterodorsal tegmental nucleus (LDT), which sends cholinergic projections to dopamine (DA) neurons in the ventral tegmental area (VTA), and medial prefrontal cortex (mPFC), which receives DA input from the VTA.	Norepinephrine	45-58	complement factor properdin	Mus musculus	266-270
31843979-3	2020	The olfactory bulb (OB) and the anterior olfactory cortex (aPC), both modulated by norepinephrine (NE), have been identified as part of a neural circuit supporting this transitory olfactory learning.	Norepinephrine	83-97	APC regulator of WNT signaling pathway	Rattus norvegicus	59-62
30935897-13	2019	CONCLUSION: When given in a manually adjusted infusion, norepinephrine effectively maintained maternal SBP during caesarean delivery under spinal anaesthesia with lower number of physician interventions, and likely less incidence of reactive hypertension and bradycardia compared to phenylephrine.	Norepinephrine	56-70	selenium binding protein 1	Homo sapiens	103-106
28232237-1	2017	It has been suggested that central norepinephrine (NE) activity may be inferred from increases in salivary alpha-amylase (SAA), but data in favor of this proposition are limited.	Norepinephrine	35-49	amylase alpha 1A	Homo sapiens	98-120
28232237-1	2017	It has been suggested that central norepinephrine (NE) activity may be inferred from increases in salivary alpha-amylase (SAA), but data in favor of this proposition are limited.	Norepinephrine	35-49	amylase alpha 1A	Homo sapiens	122-125
26549422-2	2017	Recent evidence suggests that the norepinephrine system and more specifically the alpha2A -adrenergic receptor (ADRA2A) are impacted by chronic cocaine use while also being potentially involved in the neural mechanisms underlying DD.	Norepinephrine	34-48	adrenoceptor alpha 2A	Homo sapiens	112-118
26549422-8	2017	As the relationship between DD and cocaine use was moderated by ADRA2A SNPs and by peripheral ADRA2A gene expression, we propose that the norepinephrine system is involved in DD deficits observed in cocaine using individuals.	Norepinephrine	138-152	adrenoceptor alpha 2A	Homo sapiens	64-70
26549422-8	2017	As the relationship between DD and cocaine use was moderated by ADRA2A SNPs and by peripheral ADRA2A gene expression, we propose that the norepinephrine system is involved in DD deficits observed in cocaine using individuals.	Norepinephrine	138-152	adrenoceptor alpha 2A	Homo sapiens	94-100
28865224-3	2017	The aim of this study was to investigate adrenal medulla activity in vitro depending, on a dose of CRH, AVP and OXY on adrenaline and noradrenaline release.	Norepinephrine	134-147	corticoliberin	Ovis aries	99-102
28865224-3	2017	The aim of this study was to investigate adrenal medulla activity in vitro depending, on a dose of CRH, AVP and OXY on adrenaline and noradrenaline release.	Norepinephrine	134-147	vasopressin-neurophysin 2-copeptin	Ovis aries	104-107
28865224-5	2017	The results showed that CRH stimulates adrenaline and noradrenaline release from the adrenal medulla tissue.	Norepinephrine	54-67	corticoliberin	Ovis aries	24-27
28865224-6	2017	The stimulating influence of AVP on adrenaline release was visible after the application of the two lower doses of this neuropeptide; however, AVP reduced noradrenaline release from the adrenal medulla tissue.	Norepinephrine	155-168	vasopressin-neurophysin 2-copeptin	Ovis aries	143-146
28652540-5	2017	Then, we showed that noradrenaline treatment stimulated ghrelin secretion via beta1-adrenergic receptor, and fasting-induced ghrelin elevation was completely inhibited by the beta1-adrenergic receptor antagonist in mice.	Norepinephrine	21-34	adrenergic receptor, beta 1	Mus musculus	78-103
28652540-5	2017	Then, we showed that noradrenaline treatment stimulated ghrelin secretion via beta1-adrenergic receptor, and fasting-induced ghrelin elevation was completely inhibited by the beta1-adrenergic receptor antagonist in mice.	Norepinephrine	21-34	adrenergic receptor, beta 1	Mus musculus	175-200
28848192-9	2017	In vitro activation of splenocytes isolated from immunized mice with agonists targeting TLR2 and NOD2 together with beta2-adrenergic activation (induced by epinephrine, norepinephrine, or salbutamol) resulted in decreased IFN-gamma but increased IL-17 immune responses.	Norepinephrine	169-183	hemoglobin, beta adult minor chain	Mus musculus	116-121
31101572-2	2019	Norepinephrine (NE) has a relationship with AF and nerve growth factor (NGF) injection can induce sympathetic innervation.	Norepinephrine	0-14	beta-nerve growth factor	Oryctolagus cuniculus	51-70
31101572-2	2019	Norepinephrine (NE) has a relationship with AF and nerve growth factor (NGF) injection can induce sympathetic innervation.	Norepinephrine	0-14	beta-nerve growth factor	Oryctolagus cuniculus	72-75
31490245-9	2019	The invasive/oscillometric mean arterial pressures and SBP differences were +0.1 +- 3.4 and 7.6 +- 1.6 mmHg in patients treated with nothing or a maximum norepinephrine dose of 0.6 microg/kg/min.	Norepinephrine	154-168	selenium binding protein 1	Homo sapiens	55-58
31490245-10	2019	However, treatment with very high doses of norepinephrine was associated with a steep rise in mean arterial pressures and SBP invasive/oscillometric differences (-9.5 +- 3.3 and -8.5 +- 5.2 mmHg).	Norepinephrine	43-57	selenium binding protein 1	Homo sapiens	122-125
31299273-4	2019	Here, adult rat ventricular myocytes were transfected with specifically targeted calmodulin-based GECIs and Ca2+ responses to a physiological stimulus, norepinephrine (NE, 10 muM), were observed in a) sarcoplasmic reticulum (SR), b) mitochondria, c) the space between the mitochondria and SR, termed the Mitochondria Associated Membrane space (MAM) and d) cytosol for 10 min after stimulation.	Norepinephrine	152-166	calmodulin 1	Rattus norvegicus	81-91
30651588-6	2019	In the adrenal glands of adult SHR, the expression of catecholamine biosynthetic enzymes Th, Ddc, Dbh and Pnmt was decreased along the amounts of dopamine and noradrenaline (50% and 38%, respectively, p < 0.001).	Norepinephrine	159-172	dopa decarboxylase	Rattus norvegicus	93-96
28848192-10	2017	The beta2-adrenergic antagonist propranolol could restore IFN-gamma production, whereas only the norepinephrine-induced increase in IL-17 production was abrogated.	Norepinephrine	97-111	interleukin 17A	Mus musculus	132-137
27059884-8	2016	Norepinephrine (noradrenaline) released at the distal end of the splenic nerve links to the beta2 adrenergic receptor of splenic lymphocytes that release ACh.	Norepinephrine	0-14	adrenoceptor beta 2	Homo sapiens	92-117
27059884-8	2016	Norepinephrine (noradrenaline) released at the distal end of the splenic nerve links to the beta2 adrenergic receptor of splenic lymphocytes that release ACh.	Norepinephrine	16-29	adrenoceptor beta 2	Homo sapiens	92-117
27672365-11	2016	Sensitivity to beta1 and beta2-adrenoceptor stimulation was the same in EHT as in adult CM (-logEC50: 5.9 and 6.1 for norepinephrine (NE) and epinephrine (Epi), respectively), but very low concentrations of Rp-8-Br-cAMPS were sufficient to suppress effects (-logEC50: 5.3 and 5.3 respectively for NE and Epi).	Norepinephrine	118-132	adrenoceptor beta 2	Homo sapiens	25-43
30759250-9	2019	As exemplified by norepinephrine, the release of neurotransmitters from Gnpat KO brain slices was diminished in response to strong electrical and chemical stimuli.	Norepinephrine	18-32	glyceronephosphate O-acyltransferase	Mus musculus	72-77
31048375-6	2019	Norepinephrine increases energy expenditure in brown adipose tissue by providing fatty acid substrate through lipolysis and by increasing expression of uncoupled protein-1 (UCP1).	Norepinephrine	0-14	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	152-171
31088083-2	2019	Herein, polynorepinephrine nanoparticles (PNE NPs) with a high photothermal conversion efficiency (eta) of 808 nm laser (67%), pH/thermal responsibility, and little to no long-term toxicity were synthesized from an endogenic neurotransmitter norepinephrine.	Norepinephrine	12-26	phenylalanine hydroxylase	Homo sapiens	127-129
27325446-2	2016	Here, we describe our medicinal chemistry approach to discover a novel series of highly potent, peripheral-selective, and orally available noradrenaline reuptake inhibitors with a low multidrug resistance protein 1 (MDR1) efflux ratio by cyclization of an amide moiety and introduction of an acidic group.	Norepinephrine	139-152	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	184-214
27325446-2	2016	Here, we describe our medicinal chemistry approach to discover a novel series of highly potent, peripheral-selective, and orally available noradrenaline reuptake inhibitors with a low multidrug resistance protein 1 (MDR1) efflux ratio by cyclization of an amide moiety and introduction of an acidic group.	Norepinephrine	139-152	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	216-220
27452863-7	2016	Norepinephrine depresses aggrecans expression but stimulates MMP-3, MMP-13 and RANKL production by chondrocytes through ERK1/2 and PKA pathway; these effects were abolished by an alpha2A-adrenoreceptor antagonist.	Norepinephrine	0-14	matrix metallopeptidase 3	Rattus norvegicus	61-66
27452863-7	2016	Norepinephrine depresses aggrecans expression but stimulates MMP-3, MMP-13 and RANKL production by chondrocytes through ERK1/2 and PKA pathway; these effects were abolished by an alpha2A-adrenoreceptor antagonist.	Norepinephrine	0-14	matrix metallopeptidase 13	Rattus norvegicus	68-74
27376152-5	2016	ADRA2A is the main presynaptic inhibitory feedback G protein-coupled receptor regulating norepinephrine release.	Norepinephrine	89-103	adrenoceptor alpha 2A	Homo sapiens	0-6
27378937-11	2016	Melanocortin 4 receptor mRNA levels were increased in the brains of both uDNX and UniNX compared to Sham and may contribute to increased tissue noradrenaline levels.	Norepinephrine	144-157	melanocortin 4 receptor	Rattus norvegicus	0-23
30520144-0	2019	alpha1A-adrenoceptor is involved in norepinephrine-induced proliferation of pulmonary artery smooth muscle cells via CaMKII signaling.	Norepinephrine	36-50	adrenoceptor alpha 1A	Rattus norvegicus	0-20
26721188-8	2016	Stable depletion of SNAP-25 inhibited high-K(+)-induced noradrenaline secretion.	Norepinephrine	56-69	synaptosome associated protein 25	Rattus norvegicus	20-27
27305421-10	2016	In the probabilistic sensitivity analysis, it was verified that the cost of the treatment with noradrenaline could vary between Int$2,326.53 and Int$3,644.16, while costs related to the treatment using terlipressin are not variable.	Norepinephrine	95-108	notch receptor 4	Homo sapiens	145-150
26843180-11	2016	The potency of norepinephrine for adrenergic alpha2A receptor was only about 20-fold higher compared with D3R and D4R across the three functional assays.	Norepinephrine	15-29	adrenoceptor alpha 2A	Homo sapiens	34-61
26023064-2	2016	Neurons expressing the neuropeptide, relaxin-3 (RLN3), and its cognate receptor, RXFP3, constitute a putative "ascending arousal system", which shares neuroanatomical and functional similarities with serotonin (5-HT)/dorsal raphe and noradrenaline (NA)/locus coeruleus monoamine systems.	Norepinephrine	234-247	relaxin 3	Mus musculus	37-46
26023064-2	2016	Neurons expressing the neuropeptide, relaxin-3 (RLN3), and its cognate receptor, RXFP3, constitute a putative "ascending arousal system", which shares neuroanatomical and functional similarities with serotonin (5-HT)/dorsal raphe and noradrenaline (NA)/locus coeruleus monoamine systems.	Norepinephrine	234-247	relaxin 3	Mus musculus	48-52
26741414-17	2016	Norepinephrine augments loss of neurons in CA1 and CA3 hippocampus of male piglets after fluid percussion injury in an extracellular signal-regulated kinase mitogen-activated protein kinase-dependent and interleukin-6-dependent manner but prevents loss of neurons in females after fluid percussion injury.	Norepinephrine	0-14	carbonic anhydrase 1	Homo sapiens	43-46
26691781-1	2016	Previously we showed that activation of the Nucleus of the Solitary Tract (NTS)-Nucleus Paragigantocellularis (PGi)-Locus coeruleus (LC) pathway, which theoretically culminates with norepinephrine (NE) release in dorsal hippocampus (CA1 region) and basolateral amygdala (BLA) is necessary for the consolidation of object recognition (OR) memory.	Norepinephrine	182-196	carbonic anhydrase 1	Homo sapiens	233-236
26209364-8	2015	Together, these effects induced by psychostimulants, mediated through a non-dopamine transporter-mediated mechanism involving norepinephrine and the prefrontal cortex, may also contribute importantly to the reinforcing properties of these drugs.	Norepinephrine	126-140	solute carrier family 6 member 3	Homo sapiens	76-96
31142902-4	2019	Catechol-O-Methyltransferase (COMT) is an enzyme in the metabolic inactivation of catecholamine and substances containing catecholamines such as dopamine, epinephrine, and norepinephrine.	Norepinephrine	172-186	catechol-O-methyltransferase	Homo sapiens	0-28
31142902-4	2019	Catechol-O-Methyltransferase (COMT) is an enzyme in the metabolic inactivation of catecholamine and substances containing catecholamines such as dopamine, epinephrine, and norepinephrine.	Norepinephrine	172-186	catechol-O-methyltransferase	Homo sapiens	30-34
26049402-7	2015	However, HFD-fed Glp1r-KO mice exhibited relatively less EE when housed at a cooler standard room temperature, and had relatively lower [Formula: see text] in response to a noradrenaline challenge, which is consistent with impaired BAT thermogenic capacity.	Norepinephrine	173-186	glucagon-like peptide 1 receptor	Mus musculus	17-22
30894805-0	2019	Norepinephrine Induces PTSD-Like Memory Impairments via Regulation of the beta-Adrenoceptor-cAMP/PKA and CaMK II/PKC Systems in the Basolateral Amygdala.	Norepinephrine	0-14	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	105-112
26321956-4	2015	In human neutrophils, adrenaline and noradrenaline inhibit migration, CD11b/CD18 expression, and oxidative metabolism, possibly through beta-AR, although the role of alpha1- and alpha2-AR requires further investigation.	Norepinephrine	37-50	integrin subunit alpha M	Homo sapiens	70-75
30697747-14	2019	We observe that the serotonin/norepinephrine reuptake inhibitor venlafaxine increases hippocampal matrix metalloproteinase (MMP)-9 levels as determined by ELISA and concomitantly reduces PNN integrity in murine hippocampus as determined by analysis of sections following their staining with a fluorescent PNN-binding lectin.	Norepinephrine	30-44	matrix metallopeptidase 9	Mus musculus	98-130
30697747-14	2019	We observe that the serotonin/norepinephrine reuptake inhibitor venlafaxine increases hippocampal matrix metalloproteinase (MMP)-9 levels as determined by ELISA and concomitantly reduces PNN integrity in murine hippocampus as determined by analysis of sections following their staining with a fluorescent PNN-binding lectin.	Norepinephrine	30-44	pinin	Mus musculus	187-190
30571558-0	2019	Norepinephrine-Induced Stimulation of Kir4.1/Kir5.1 Is Required for the Activation of NaCl Transporter in Distal Convoluted Tubule.	Norepinephrine	0-14	potassium inwardly-rectifying channel, subfamily J, member 10	Mus musculus	38-44
31061349-3	2019	In addition, indirect vascular contractions induced by noradrenaline (NA), the release of which is mediated through Ang II receptor type 1 (AT1) existing at the sympathetic nerve terminals (SNTs), also contribute to the vasopressor effects of Ang II.	Norepinephrine	55-68	angiotensin II receptor type 1	Homo sapiens	116-143
26321956-4	2015	In human neutrophils, adrenaline and noradrenaline inhibit migration, CD11b/CD18 expression, and oxidative metabolism, possibly through beta-AR, although the role of alpha1- and alpha2-AR requires further investigation.	Norepinephrine	37-50	adrenergic receptor, beta 1	Mus musculus	136-143
30376995-6	2018	Blockade of TRPM8 channels also reduced WS-12- and tBHP-evoked norepinephrine secretion from the cells.	Norepinephrine	63-77	transient receptor potential cation channel, subfamily M, member 8	Rattus norvegicus	12-17
26203906-0	2015	Norepinephrine-Induced Adrenergic Activation Strikingly Increased the Atrial Fibrillation Duration through beta1- and alpha1-Adrenergic Receptor-Mediated Signaling in Mice.	Norepinephrine	0-14	adrenergic receptor, beta 1	Mus musculus	107-144
30070610-6	2018	In a separate series of experiments, we show that insulin stimulates ULK1 phosphorylation at Ser757 (inhibitory site) in both hypoglycemic and euglycemic conditions, suggesting that counter-regulatory hormones (such as epinephrine, norepinephrine, growth hormone and glucagon) have limited effects on autophagy signaling in human skeletal muscle.	Norepinephrine	232-246	unc-51 like autophagy activating kinase 1	Homo sapiens	69-73
29867144-3	2018	Copper imaging and gene expression analysis in zebrafish identifies the locus coeruleus-norepinephrine (LC-NE) system, a vertebrate-specific neuromodulatory circuit critical for regulating sleep, arousal, attention, memory and emotion, as a copper-enriched unit with high levels of copper transporters CTR1 and ATP7A and the copper enzyme dopamine beta-hydroxylase (DBH) that produces NE.	Norepinephrine	88-102	solute carrier family 31 member 1	Danio rerio	302-306
30009731-9	2018	While comparing the accuracy of individual variable/system of SOFA, the accuracy rate of norepinephrine of UC group was much higher than NUC group [80.7% (71/88) vs. 66.1% (72/109), chi2 = 5.235, P = 0.022], but the accuracy of Glasgow coma scale (GCS) was much lower in NUC group [38.6% (27/70) vs. 81.6% (71/87), chi2 = 30.629, P &lt; 0.001].	Norepinephrine	89-103	nucleobindin 1	Homo sapiens	271-274
30009731-14	2018	The calculating error in norepinephrine from NUC physicians was higher than the UC group [33.9% (37/109) vs. 19.3% (17/88), chi2 = 5.235, P = 0.022], there was no significant difference in any other first type mistakes between the two groups.	Norepinephrine	25-39	nucleobindin 1	Homo sapiens	45-48
29274505-2	2018	Skeletal cannabinoid type 1 (CB1) receptor signaling transmits retrograde signals that restrain norepinephrine (NE) release, thus transiently stimulating bone formation following an acute challenge, suggesting a feedback circuit between sympathetic nerve terminals and osteoblasts.	Norepinephrine	96-110	cannabinoid receptor 1 (brain)	Mus musculus	29-32
29386392-0	2018	Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice.	Norepinephrine	50-64	leucine-rich repeat kinase 2	Mus musculus	86-91
29233551-3	2018	We showed that continuing BMP4 and curtailing FGF2 in vitro, augmented with corticosteroid mimetic, induced these cells to upregulate the chromaffin cell-specific marker PNMT and other CA synthesis and storage markers, and we demonstrated noradrenaline and adrenaline by Faglu and high-performance liquid chromatography.	Norepinephrine	239-252	bone morphogenetic protein 4	Homo sapiens	26-30
25912576-0	2015	Norepinephrine attenuates CXCR4 expression and the corresponding invasion of MDA-MB-231 breast cancer cells via beta2-adrenergic receptors.	Norepinephrine	0-14	C-X-C motif chemokine receptor 4	Homo sapiens	26-31
25912576-6	2015	The CXCR4 gene demonstrated the greatest response to norepinephrine treatment, with a reduction of transcription of 95.7%, and was the focus of subsequent investigations.	Norepinephrine	53-67	C-X-C motif chemokine receptor 4	Homo sapiens	4-9
25912576-7	2015	Real-time reverse transcription-PCR was used to determine the level of CXCR4 transcription after treatment with norepinephrine at various concentrations and for different durations.	Norepinephrine	112-126	C-X-C motif chemokine receptor 4	Homo sapiens	71-76
25912576-8	2015	RESULTS: The results revealed that norepinephrine reduced CXCR4 transcription in a dose-dependent manner.	Norepinephrine	35-49	C-X-C motif chemokine receptor 4	Homo sapiens	58-63
25912576-9	2015	Norepinephrine was also found to exert a negative effect on CXCR4 translational expression, as evidenced by a 44 +- 1.7% reduction in expression after a 12-h treatment with 10 microM norepinephrine.	Norepinephrine	0-14	C-X-C motif chemokine receptor 4	Homo sapiens	60-65
25912576-9	2015	Norepinephrine was also found to exert a negative effect on CXCR4 translational expression, as evidenced by a 44 +- 1.7% reduction in expression after a 12-h treatment with 10 microM norepinephrine.	Norepinephrine	183-197	C-X-C motif chemokine receptor 4	Homo sapiens	60-65
25912576-11	2015	Finally, we found the specific beta2-adrenergic antagonist, ICI 118,551, eliminated the impact of norepinephrine on CXCR4 expression.	Norepinephrine	98-112	C-X-C motif chemokine receptor 4	Homo sapiens	116-121
25912576-12	2015	CONCLUSIONS: Norepinephrine attenuates CXCR4 expression and the corresponding invasion of MDA-MB-231 tumor cells via the beta2-adrenergic receptor.	Norepinephrine	13-27	C-X-C motif chemokine receptor 4	Homo sapiens	39-44
25912576-12	2015	CONCLUSIONS: Norepinephrine attenuates CXCR4 expression and the corresponding invasion of MDA-MB-231 tumor cells via the beta2-adrenergic receptor.	Norepinephrine	13-27	adrenoceptor beta 2	Homo sapiens	121-146
25793511-10	2015	Central GLP-1R activation also increased NTS expression of dopamine-beta-hydroxylase, a key enzyme in noradrenaline synthesis, indicating a biological link between these two systems.	Norepinephrine	102-115	glucagon-like peptide 1 receptor	Rattus norvegicus	8-14
25304347-4	2015	To activate nuclear adrenergic receptors in adult cardiac myocytes, uptake of endogenous catecholamines epinephrine and norepinephrine occurs via organic cation transporter 3 (OCT3), a member of the slc22a family of genes.	Norepinephrine	120-134	OCTN3	Homo sapiens	146-174
25304347-4	2015	To activate nuclear adrenergic receptors in adult cardiac myocytes, uptake of endogenous catecholamines epinephrine and norepinephrine occurs via organic cation transporter 3 (OCT3), a member of the slc22a family of genes.	Norepinephrine	120-134	OCTN3	Homo sapiens	176-180
25359531-9	2015	Noradrenaline in the CeA was increased by CRD, further increased by CRH, and inhibited by CRH-R1 antagonist.	Norepinephrine	0-13	corticotropin releasing hormone receptor 1	Rattus norvegicus	90-96
25566095-6	2014	beta3-adrenoceptor agonist (BRL37344) reduced baseline vascular resistance, the tyramine-stimulated norepinephrine overflow and the positive inotropic response to tyramine in hypertensive but not normotensive rats.	Norepinephrine	100-114	adrenoceptor beta 3	Rattus norvegicus	0-18
25566095-7	2014	beta3-adrenoceptor antagonist (SR59230A) reduced tyramine-stimulated norepinephrine release in both strains and the secretion of epinephrine in hypertensive rats.	Norepinephrine	69-83	adrenoceptor beta 3	Rattus norvegicus	0-18
25549103-5	2014	After the memory reactivation we administer an oral dose of 40 mg of propranolol HCl, a beta-adrenergic receptor antagonist that indirectly targets the protein synthesis required for reconsolidation by inhibiting the noradrenaline-stimulated CREB phosphorylation.	Norepinephrine	217-230	cAMP responsive element binding protein 1	Homo sapiens	242-246
25218306-0	2014	VEGF-induced antidepressant effects involve modulation of norepinephrine and serotonin systems.	Norepinephrine	58-72	vascular endothelial growth factor A	Mus musculus	0-4
25218306-7	2014	However, we found imbalances in brain monoamine contents, in which the levels of norepinephrine and serotonin, but not dopamine, were decreased exclusively in the regions where VEGF was expressed.	Norepinephrine	81-95	vascular endothelial growth factor A	Mus musculus	177-181
25218306-12	2014	These data suggest that VEGF-induced antidepressant-like effects involve modulation of norepinephrine and serotonin systems.	Norepinephrine	87-101	vascular endothelial growth factor A	Mus musculus	24-28
25402186-4	2014	In the present study, using immunodetection methods, we revealed the presence of several proteins important for the dopamine uptake and signalling in mammalian sperm, specifically monoamine transporters as dopamine (DAT), serotonin (SERT) and norepinephrine (NET) transporters in equine sperm.	Norepinephrine	243-257	solute carrier family 6 member 3	Homo sapiens	216-219
25355210-9	2014	Collectively, these results indicate that chronic restraint stress impairs the alpha1-AR LTD by reducing the function of presynaptic CB1 receptors and reveal a novel mechanism by which noradrenaline controls synaptic strength and plasticity in the DRn.	Norepinephrine	185-198	cannabinoid receptor 1	Rattus norvegicus	133-136
25049076-1	2014	The beta2-adrenergic receptor (beta2AR) is the prototypic member of G protein-coupled receptors (GPCRs) involved in the production of physiological responses to adrenaline and noradrenaline.	Norepinephrine	176-189	adrenoceptor beta 2	Homo sapiens	4-29
25049076-1	2014	The beta2-adrenergic receptor (beta2AR) is the prototypic member of G protein-coupled receptors (GPCRs) involved in the production of physiological responses to adrenaline and noradrenaline.	Norepinephrine	176-189	adrenoceptor beta 2	Homo sapiens	31-38
24553734-2	2014	We found that microinfusion of norepinephrine (NE) into the CA1 area of the dorsal hippocampus during the early phase (0 h) after extinction enhanced extinction LTM at 2 and 14 days after extinction.	Norepinephrine	31-45	carbonic anhydrase 1	Homo sapiens	60-63
24451568-0	2014	Pharmacological characterization of BDNF promoters I, II and IV reveals that serotonin and norepinephrine input is sufficient for transcription activation.	Norepinephrine	91-105	brain-derived neurotrophic factor	Rattus norvegicus	36-40
24384038-9	2014	The selective sigma1 receptor antagonist S1RA results in inhibition of formalin-evoked Glu release, no modification of GABA levels, and enhancement of noradrenaline (NA) levels.	Norepinephrine	151-164	sigma non-opioid intracellular receptor 1	Rattus norvegicus	14-29
24553185-5	2014	Norepinephrine (NE) reduced the nAChR currents, an effect partially mimicked by a beta-adrenergic receptor agonist, isoproterenol, and blocked by a beta-adrenergic receptor antagonist, propranolol.	Norepinephrine	0-14	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	32-37
24554716-0	2014	Growth differentiation factor (GDF)-15 blocks norepinephrine-induced myocardial hypertrophy via a novel pathway involving inhibition of epidermal growth factor receptor transactivation.	Norepinephrine	46-60	growth differentiation factor 15	Homo sapiens	0-38
24554716-3	2014	In this present study, we demonstrate that GDF-15 blocks norepinephrine (NE)-induced myocardial hypertrophy through a novel pathway involving inhibition of EGFR transactivation.	Norepinephrine	57-71	growth differentiation factor 15	Homo sapiens	43-49
23978467-4	2013	The noradrenaline that is recruited by the action of the antidepressants on reuptake transporters has been proposed to act through beta2-adrenoceptors (beta2-ARs) to lead to the observed therapeutic effect.	Norepinephrine	4-17	hemoglobin, beta adult minor chain	Mus musculus	131-136
23978467-4	2013	The noradrenaline that is recruited by the action of the antidepressants on reuptake transporters has been proposed to act through beta2-adrenoceptors (beta2-ARs) to lead to the observed therapeutic effect.	Norepinephrine	4-17	hemoglobin, beta adult minor chain	Mus musculus	152-157
23978467-8	2013	More particularly, we report that antidepressant-recruited noradrenaline acts, within dorsal root ganglia, on beta2-ARs expressed by non-neuronal satellite cells.	Norepinephrine	59-72	hemoglobin, beta adult minor chain	Mus musculus	110-115
24072708-9	2013	Indicative of a direct regulatory role for Them2 in heat production, cultured primary brown adipocytes from Them2(-/-) mice exhibited increased norepinephrine-mediated triglyceride hydrolysis and increased rates of O2 consumption, together with elevated expression of thermogenic genes.	Norepinephrine	144-158	acyl-CoA thioesterase 13	Mus musculus	108-113
24010080-3	2013	There is a close association between salivary alpha amylase and plasma norepinephrine under stressful physical conditions.	Norepinephrine	71-85	amylase alpha 1A	Homo sapiens	37-59
23806689-2	2013	We previously reported that noradrenaline (NA) suppressed K(+) currents via Gi/o protein-coupled alpha1B-adrenergic receptor (alpha1B-AR) in human osteoblast SaM-1 cells.	Norepinephrine	28-41	adrenoceptor alpha 1B	Homo sapiens	97-124
23806689-2	2013	We previously reported that noradrenaline (NA) suppressed K(+) currents via Gi/o protein-coupled alpha1B-adrenergic receptor (alpha1B-AR) in human osteoblast SaM-1 cells.	Norepinephrine	28-41	adrenoceptor alpha 1B	Homo sapiens	126-136
23672601-6	2013	We also show here that Slc6a17mRNA is up-regulated in animals subjected to short term food deprivation as well as animals treated with the serotonin reuptake inhibitor fluoxetine and the dopamine/noradrenaline reuptake inhibitor bupropion.	Norepinephrine	196-209	solute carrier family 6 member 17	Rattus norvegicus	23-30
23364786-0	2013	Differential phosphorylation, desensitization, and internalization of alpha1A-adrenoceptors activated by norepinephrine and oxymetazoline.	Norepinephrine	105-119	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	70-77
23364786-3	2013	It is well established that alpha1A-ARs are less phosphorylated, desensitized, and internalized on exposure to the phenethylamines norepinephrine (NE), epinephrine, or phenylephrine (PE) than are the alpha1B and alpha1D subtypes.	Norepinephrine	131-145	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	28-35
23302980-12	2013	CONCLUSIONS: This study provides evidence that anandamide and PEA induce peripheral antinociception activating CB1 and CB2 cannabinoid receptors, respectively, stimulating an endogenous norepinephrine release that activates peripheral adrenoceptors inducing antinociception.	Norepinephrine	186-200	cannabinoid receptor 1	Rattus norvegicus	111-114
23524625-1	2013	OBJECTIVES: We previously demonstrated that the direct microinjection of cholinesterase inhibitor (neostigmine) into the hippocampus in rats activated the hypothalamo-pituitary -adrenal axis and increased the level of norepinephrine in the plasma.	Norepinephrine	218-232	butyrylcholinesterase	Rattus norvegicus	73-87
22865387-12	2012	Interestingly, the heart of P2Y(4)-null mice displayed a reduced sympathetic innervation associated with a decreased norepinephrine level.	Norepinephrine	117-131	pyrimidinergic receptor P2Y, G-protein coupled, 4	Mus musculus	28-34
22723268-7	2012	Intriguingly, not only ACTH, but also norepinephrine stimulated lipolysis were substantially reduced demonstrating functional significance of MC2R for general lipolysis pathway.	Norepinephrine	38-52	melanocortin 2 receptor	Mus musculus	142-146
28888989-4	2017	alpha1A-Adrenergic receptor interaction with beta-arrestins (colocalization/coimmunoprecipitation) was induced by noradrenaline and oxymetazoline and, to a lesser extent, by phorbol myristate acetate.	Norepinephrine	114-127	adrenoceptor alpha 1D	Homo sapiens	0-27
29123236-4	2017	Leptin injection into the ventromedial hypothalamus (VMH) increased 2-deoxy-D-glucose (2DG) uptake in red-type skeletal muscle in wild-type (WT) mice accompanied with increased phosphorylation of the insulin receptor (IR) and Akt as well as of norepinephrine (NE) turnover in the muscle.	Norepinephrine	244-258	leptin	Mus musculus	0-6
29046732-2	2017	For example, the beta-3 adrenergic receptor (ADRB3) responds to noradrenaline and mediates lipolysis in adipocytes.	Norepinephrine	64-77	adrenoceptor beta 3	Homo sapiens	17-43
29046732-2	2017	For example, the beta-3 adrenergic receptor (ADRB3) responds to noradrenaline and mediates lipolysis in adipocytes.	Norepinephrine	64-77	adrenoceptor beta 3	Homo sapiens	45-50
28598954-4	2017	METHOD: We used human renal proximal tubule cells to investigate the effects of noradrenaline on SGLT2 regulation.	Norepinephrine	80-93	solute carrier family 5 member 2	Homo sapiens	97-102
22441984-7	2012	Accordingly, norepinephrine-induced ROS production, promoter methylation, and PKCepsilon gene repression were completely abrogated by knockdown of Nox1 in cardiomyocytes.	Norepinephrine	13-27	NADPH oxidase 1	Rattus norvegicus	147-151
28502584-6	2017	miR-325-3p blocked norepinephrine (NE) induced Aanat activation in cultured pinealocytes.	Norepinephrine	19-33	aralkylamine N-acetyltransferase	Rattus norvegicus	47-52
22441984-8	2012	These findings provide evidence of a novel interaction between elevated norepinephrine and epigenetic repression of PKCepsilon gene in the heart mediated by Nox1-dependent oxidative stress and suggest new insights of molecular mechanisms linking the heightened sympathetic activity to aberrant cardioprotection and increased ischemic vulnerability in the heart.	Norepinephrine	72-86	NADPH oxidase 1	Rattus norvegicus	157-161
22379120-5	2012	To examine the effects of increasing concentrations of the endogenous agonist norepinephrine on the speed and extent of alpha(2A)-AR activation with very high temporal resolution, we took advantage of a fluorophore-containing alpha(2A)-AR sensor.	Norepinephrine	78-92	adrenoceptor alpha 2A	Homo sapiens	120-132
22379120-5	2012	To examine the effects of increasing concentrations of the endogenous agonist norepinephrine on the speed and extent of alpha(2A)-AR activation with very high temporal resolution, we took advantage of a fluorophore-containing alpha(2A)-AR sensor.	Norepinephrine	78-92	adrenoceptor alpha 2A	Homo sapiens	226-238
22379120-8	2012	To analyze the ability of norepinephrine to trigger a downstream intracellular response after alpha(2A)-AR stimulation, we monitored the kinetics and amplitude of G(i) activation in real time by using a fluorophore-containing G(i) sensor.	Norepinephrine	26-40	adrenoceptor alpha 2A	Homo sapiens	94-106
22579288-3	2012	BMP8B is induced by nutritional and thermogenic factors in mature BAT, increasing the response to noradrenaline through enhanced p38MAPK/CREB signaling and increased lipase activity.	Norepinephrine	98-111	bone morphogenetic protein 8b	Mus musculus	0-5
22260985-4	2012	In the presence of endothelium, neurogenic and exogenous noradrenaline vasoconstrictions were enhanced by L-NOArg (n=7, P&lt;0.05 and P&lt;0.01 respectively) and ODQ (n=7, both P&lt;0.05); in denuded arteries, nNOS inhibition with N(omega)-propyl-L-arginine increased neurogenic contraction (n=7, P&lt;0.05).	Norepinephrine	57-70	nitric oxide synthase 1	Sus scrofa	210-214
28472693-0	2017	Salivary alpha-amylase and noradrenaline responses to corticotropin-releasing hormone administration in humans.	Norepinephrine	27-40	corticotropin releasing hormone	Homo sapiens	54-85
28472693-7	2017	Results showed that CRH administration increased plasma noradrenaline and cortisol concentrations, sAA activity, heart rate, as well as self-reported side effects (i.e. flushing in the facial area, heart rate changes, giddiness, malaise and restlessness) and stress perception, while plasma adrenaline levels remained unaffected.	Norepinephrine	56-69	corticotropin releasing hormone	Homo sapiens	20-23
28472693-8	2017	In the CRH group, the total increase of sAA activity significantly correlated with noradrenaline release, indicating that sAA activity reflects pharmacologically induced sympathetic activation.	Norepinephrine	83-96	corticotropin releasing hormone	Homo sapiens	7-10
28423914-4	2017	Neuropeptide Y is co-localized with noradrenaline in central and sympathetic nervous systems.	Norepinephrine	36-49	neuropeptide Y	Homo sapiens	0-14
28707163-1	2017	Dopamine-beta-hydroxylase (DBH, EC 1.14.17.1), an oxido-reductase that catalyses the conversion of dopamine to norepinephrine, is largely expressed in sympathetic neurons and adrenal medulla.	Norepinephrine	111-125	dopamine beta-hydroxylase	Homo sapiens	0-25
28707163-1	2017	Dopamine-beta-hydroxylase (DBH, EC 1.14.17.1), an oxido-reductase that catalyses the conversion of dopamine to norepinephrine, is largely expressed in sympathetic neurons and adrenal medulla.	Norepinephrine	111-125	dopamine beta-hydroxylase	Homo sapiens	27-30
22398028-0	2012	Norepinephrine suppresses IFN-gamma and TNF-alpha production by murine intestinal intraepithelial lymphocytes via the beta1 adrenoceptor.	Norepinephrine	0-14	adrenergic receptor, beta 1	Mus musculus	118-136
21855626-3	2012	We have also learned that engagement of the beta(2)AR on lymphocytes, by either norepinephrine or a selective pharmacologic ligand, regulates the level of lymphocyte activity differentially, depending on the time of receptor engagement in relation to the activation and differentiation state of the cell, the molecular signaling pathway activated, and the cytokine microenvironment.	Norepinephrine	80-94	adrenoceptor beta 2	Homo sapiens	44-53
23507624-2	2012	Norepinephrine (NE) release due to sympathetic activation leads to a Th2 deviation via the beta-2 adrenergic receptor Beta-2 adrenergic receptor (beta-2AR) and could increase cancer progression.	Norepinephrine	0-14	adrenoceptor beta 2	Homo sapiens	91-117
23507624-2	2012	Norepinephrine (NE) release due to sympathetic activation leads to a Th2 deviation via the beta-2 adrenergic receptor Beta-2 adrenergic receptor (beta-2AR) and could increase cancer progression.	Norepinephrine	0-14	adrenoceptor beta 2	Homo sapiens	118-144
23507624-2	2012	Norepinephrine (NE) release due to sympathetic activation leads to a Th2 deviation via the beta-2 adrenergic receptor Beta-2 adrenergic receptor (beta-2AR) and could increase cancer progression.	Norepinephrine	0-14	adrenoceptor beta 2	Homo sapiens	146-154
22914593-4	2012	Exercise significantly elevated endogenous norepinephrine (measured via the biomarker, salivary alpha-amylase) in both aMCI patients and controls.	Norepinephrine	43-57	amylase alpha 1A	Homo sapiens	87-109
22916250-15	2012	CONCLUSIONS: Beta-adrenergic receptor-1 mediates liver norepinephrine modulation of the pro-inflammatory response in CCl(4)-treated mice with bacterial-DNA.	Norepinephrine	55-69	chemokine (C-C motif) ligand 4	Mus musculus	117-123
22116378-9	2012	The manipulation of the noradrenaline activity was confirmed by salivary alpha-amylase (sAA) samples taken pre-, during and post-exposure.	Norepinephrine	24-37	amylase alpha 1A	Homo sapiens	64-86
22116378-9	2012	The manipulation of the noradrenaline activity was confirmed by salivary alpha-amylase (sAA) samples taken pre-, during and post-exposure.	Norepinephrine	24-37	amylase alpha 1A	Homo sapiens	88-91
22116378-11	2012	Manipulation of noradrenaline levels with YOH was successful, with significantly higher levels of sAA in the YOH group when entering exposure.	Norepinephrine	16-29	amylase alpha 1A	Homo sapiens	98-101
21900458-5	2011	TAL NaCl reabsorption is subject to exquisite control by hormones like vasopressin, parathyroid, glucagon, and adrenergic agonists (epinephrine and norepinephrine) that stimulate NaCl reabsorption.	Norepinephrine	148-162	transaldolase 1	Homo sapiens	0-3
22184028-1	2011	To interfere with the drug-cue memory processes of addicts such as reconsolidation by the administration of the beta-adrenergic receptor (beta-AR) of norepinephrine (NE) antagonist propranolol (PRO) has become a potential therapy in the future to decrease or inhibit relapse.	Norepinephrine	150-164	adrenergic receptor, beta 1	Mus musculus	112-136
22184028-1	2011	To interfere with the drug-cue memory processes of addicts such as reconsolidation by the administration of the beta-adrenergic receptor (beta-AR) of norepinephrine (NE) antagonist propranolol (PRO) has become a potential therapy in the future to decrease or inhibit relapse.	Norepinephrine	150-164	adrenergic receptor, beta 1	Mus musculus	138-145
21740976-7	2011	Additionally, saliva samples were taken throughout the experimental session to examine salivary alpha-amylase, a biomarker for norepinephrine.	Norepinephrine	127-141	amylase alpha 1A	Homo sapiens	87-109
21726532-5	2011	Employing a novel anti-phospho-Ser-412-specific antibody, we demonstrate that this site in PKD is rapidly phosphorylated in primary cardiac myocytes exposed to hypertrophic agonists, including norepinephrine (NE) and endothelin-1 (ET-1).	Norepinephrine	193-207	protein kinase D1	Homo sapiens	91-94
28282374-0	2017	Depletion of cardiac catecholamine stores impairs cardiac norepinephrine re-uptake by downregulation of the norepinephrine transporter.	Norepinephrine	58-72	solute carrier family 6 member 2	Rattus norvegicus	108-134
28282374-1	2017	In heart failure (HF), a disturbed cardiac norepinephrine (NE) homeostasis is characterized by depleted cardiac NE stores, impairment of the cardiac NE re-uptake by the neuronal norepinephrine transporter (NET) and enhanced cardiac NE net release.	Norepinephrine	43-57	solute carrier family 6 member 2	Rattus norvegicus	178-204
28282374-1	2017	In heart failure (HF), a disturbed cardiac norepinephrine (NE) homeostasis is characterized by depleted cardiac NE stores, impairment of the cardiac NE re-uptake by the neuronal norepinephrine transporter (NET) and enhanced cardiac NE net release.	Norepinephrine	43-57	solute carrier family 6 member 2	Rattus norvegicus	206-209
28282374-1	2017	In heart failure (HF), a disturbed cardiac norepinephrine (NE) homeostasis is characterized by depleted cardiac NE stores, impairment of the cardiac NE re-uptake by the neuronal norepinephrine transporter (NET) and enhanced cardiac NE net release.	Norepinephrine	43-57	solute carrier family 6 member 2	Rattus norvegicus	235-238
28352352-3	2017	Noradrenaline-induced lipolysis was enhanced by caffeine, which markedly increased the protein expression of adipose triglyceride lipase and hormone sensitive lipase.	Norepinephrine	0-13	patatin-like phospholipase domain containing 2	Mus musculus	109-136
28352358-13	2017	In conclusion, the current study suggests that under conditions of stress, VEGF serves a role in the mechanism of action of DMI, through modulating activity of the norepinephrine system.	Norepinephrine	164-178	vascular endothelial growth factor A	Rattus norvegicus	75-79
27778639-1	2017	Context: Dopamine beta-hydroxylase (DBH) deficiency is a rare genetic disorder characterized by failure to convert dopamine to norepinephrine.	Norepinephrine	127-141	dopamine beta-hydroxylase	Homo sapiens	9-34
27778639-1	2017	Context: Dopamine beta-hydroxylase (DBH) deficiency is a rare genetic disorder characterized by failure to convert dopamine to norepinephrine.	Norepinephrine	127-141	dopamine beta-hydroxylase	Homo sapiens	36-39
28508370-5	2017	Tyrosine hydroxylase, dopamine beta hydroxylase are the key enzymes for the synthesis of norepinephrine; and neuropeptide Y (NPY) is the peptide that is co-stored and co-released with norepinephrine.	Norepinephrine	89-103	dopamine beta-hydroxylase	Homo sapiens	22-47
28508370-5	2017	Tyrosine hydroxylase, dopamine beta hydroxylase are the key enzymes for the synthesis of norepinephrine; and neuropeptide Y (NPY) is the peptide that is co-stored and co-released with norepinephrine.	Norepinephrine	89-103	neuropeptide Y	Homo sapiens	109-123
28508370-5	2017	Tyrosine hydroxylase, dopamine beta hydroxylase are the key enzymes for the synthesis of norepinephrine; and neuropeptide Y (NPY) is the peptide that is co-stored and co-released with norepinephrine.	Norepinephrine	89-103	neuropeptide Y	Homo sapiens	125-128
28508370-5	2017	Tyrosine hydroxylase, dopamine beta hydroxylase are the key enzymes for the synthesis of norepinephrine; and neuropeptide Y (NPY) is the peptide that is co-stored and co-released with norepinephrine.	Norepinephrine	184-198	neuropeptide Y	Homo sapiens	109-123
28508370-5	2017	Tyrosine hydroxylase, dopamine beta hydroxylase are the key enzymes for the synthesis of norepinephrine; and neuropeptide Y (NPY) is the peptide that is co-stored and co-released with norepinephrine.	Norepinephrine	184-198	neuropeptide Y	Homo sapiens	125-128
27651310-6	2016	Notably, clinically approved antihypertensive drugs that block L-type VDCC prevented the effects of chronic stress or norepinephrine on the IGF2/IGF-1R signaling cascade, along with transformation of lung epithelial cells and lung tumor formation.	Norepinephrine	118-132	insulin-like growth factor 2	Mus musculus	140-144
27734680-0	2016	Empirical Valence Bond Simulations of the Hydride-Transfer Step in the Monoamine Oxidase A Catalyzed Metabolism of Noradrenaline.	Norepinephrine	115-128	monoamine oxidase A	Homo sapiens	71-90
27734680-1	2016	Monoamine oxidases (MAOs) A and B are flavoenzymes responsible for the metabolism of biogenic amines, such as dopamine, serotonin, and noradrenaline (NA), which is why they have been extensively implicated in the etiology and course of various neurodegenerative disorders and, accordingly, used as primary pharmacological targets to treat these debilitating cognitive diseases.	Norepinephrine	135-148	monoamine oxidase A	Homo sapiens	0-33
27734680-3	2016	In this work, we present atomistic empirical valence bond simulations of the rate-limiting step of the MAO-A-catalyzed NA (norepinephrine) degradation, involving hydride transfer from the substrate alpha-methylene group to the flavin moiety of the flavin adenine dinucleotide prosthetic group, employing the full dimensionality and thermal fluctuations of the hydrated enzyme, with extensive configurational sampling.	Norepinephrine	123-137	monoamine oxidase A	Homo sapiens	103-108
27501468-8	2016	Western blot results showed that over-expression of miR-181a and miR-29b significantly repressed protein levels of NET, which is accompanied by a reduced [3 H] norepinephrine uptake, and glucocorticoid receptors in PC12 cells.	Norepinephrine	160-174	solute carrier family 6 member 2	Rattus norvegicus	115-118
27490896-6	2016	CTGF mRNA and protein levels were decreased in LV following RSD (p&lt;0.01), accompanied by decreased expression of norepinephrine, renin, angiotensin II and aldosterone in plasma (p&lt;0.05) compared with untreated MI rats.	Norepinephrine	116-130	cellular communication network factor 2	Rattus norvegicus	0-4
26919286-2	2016	Catechol-O-methyl transferase (COMT) is a catecholamine-degrading enzyme, the substrates of which include dopamine, epinephrine, and norepinephrine.	Norepinephrine	133-147	catechol-O-methyltransferase	Rattus norvegicus	0-29
26919286-2	2016	Catechol-O-methyl transferase (COMT) is a catecholamine-degrading enzyme, the substrates of which include dopamine, epinephrine, and norepinephrine.	Norepinephrine	133-147	catechol-O-methyltransferase	Rattus norvegicus	31-35
26776902-2	2016	In particular, converging lines of evidence have documented that these maladaptive manifestations of aggression are influenced by monoamine oxidase A (MAOA), the enzyme that catalyzes the degradation of brain serotonin, norepinephrine and dopamine.	Norepinephrine	220-234	monoamine oxidase A	Homo sapiens	130-149
26776902-2	2016	In particular, converging lines of evidence have documented that these maladaptive manifestations of aggression are influenced by monoamine oxidase A (MAOA), the enzyme that catalyzes the degradation of brain serotonin, norepinephrine and dopamine.	Norepinephrine	220-234	monoamine oxidase A	Homo sapiens	151-155
26959714-1	2016	OBJECTIVE: Dopamine-beta-hydroxylase (DBH), an enzyme that converts dopamine into norepinephrine, is a drug target in cardiovascular and neuropsychiatric disorders.	Norepinephrine	82-96	dopamine beta-hydroxylase	Homo sapiens	11-36
26959714-1	2016	OBJECTIVE: Dopamine-beta-hydroxylase (DBH), an enzyme that converts dopamine into norepinephrine, is a drug target in cardiovascular and neuropsychiatric disorders.	Norepinephrine	82-96	dopamine beta-hydroxylase	Homo sapiens	38-41
20832122-1	2011	There is growing evidence that blood levels of brain-derived neurotrophic factor (BDNF) and 3-methoxy-4-hydroxyphenylglycol (MHPG), a major metabolite of noradrenaline, are related to depression-associated personality traits as well as to depressive, suicidal and anxious states.	Norepinephrine	154-167	brain derived neurotrophic factor	Homo sapiens	47-80
20832122-1	2011	There is growing evidence that blood levels of brain-derived neurotrophic factor (BDNF) and 3-methoxy-4-hydroxyphenylglycol (MHPG), a major metabolite of noradrenaline, are related to depression-associated personality traits as well as to depressive, suicidal and anxious states.	Norepinephrine	154-167	brain derived neurotrophic factor	Homo sapiens	82-86
21237150-2	2011	administered (+-)-epibatidine (a non-selective agonist of nicotinic acetylcholine receptors) elevates plasma noradrenaline and adrenaline through brain nicotinic acetylcholine receptor-mediated mechanisms in rats.	Norepinephrine	109-122	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	58-90
27043247-1	2016	Synaptotagmin 7 (Syt7) is expressed in cardiac sympathetic nerve terminals where norepinephrine (NE) is released in both Ca(2+)-dependent exocytosis and Ca(2+)-independent norepinephrine transporter (NET)-mediated overflow.	Norepinephrine	81-95	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Mus musculus	172-198
20933023-0	2011	Central injections of noradrenaline induce reinstatement of cocaine seeking and increase c-fos mRNA expression in the extended amygdala.	Norepinephrine	22-35	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	89-94
27043247-1	2016	Synaptotagmin 7 (Syt7) is expressed in cardiac sympathetic nerve terminals where norepinephrine (NE) is released in both Ca(2+)-dependent exocytosis and Ca(2+)-independent norepinephrine transporter (NET)-mediated overflow.	Norepinephrine	81-95	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Mus musculus	200-203
21253359-1	2011	The pancreatic beta cell harbors alpha2-adrenergic and glucagon-like peptide-1 (GLP-1) receptors on its plasma membrane to sense the corresponding ligands adrenaline/noradrenaline and GLP-1 to govern glucose-stimulated insulin secretion.	Norepinephrine	166-179	glucagon	Rattus norvegicus	80-85
27124282-7	2016	RESULTS: At baseline, serum FABP4 level was correlated with adiposity, renal dysfunction and noradrenaline level.	Norepinephrine	93-106	fatty acid binding protein 4	Homo sapiens	28-33
27124282-9	2016	Change in FABP4 level was positively correlated with change in levels of fasting glucose (r = 0.329, P = 0.044), HbA1c (r = 0.329, P = 0.044) and noradrenaline (r = 0.329, P = 0.041) but was not significantly correlated with change in adiposity or other variables.	Norepinephrine	146-159	fatty acid binding protein 4	Homo sapiens	10-15
26891013-3	2016	Dopamine beta-hydroxylase (DbetaH) is a key enzyme that converts dopamine to norepinephrine and for which activity and levels are under strong genetic control.	Norepinephrine	77-91	dopamine beta-hydroxylase	Homo sapiens	0-25
26891013-3	2016	Dopamine beta-hydroxylase (DbetaH) is a key enzyme that converts dopamine to norepinephrine and for which activity and levels are under strong genetic control.	Norepinephrine	77-91	dopamine beta-hydroxylase	Homo sapiens	27-33
20875861-2	2011	Recently, we showed that AP-2beta, a member of the AP2 family, plays a critical role in the development of sympathetic neurons and locus coeruleus and their norepinephrine (NE) neurotransmitter phenotype.	Norepinephrine	157-171	transcription factor AP-2 beta	Mus musculus	25-33
20813157-5	2010	Pretreatment with the selective alpha(1B)-adrenergic receptor antagonist chloroethylclonidine eliminated the inhibitory effect of noradrenaline.	Norepinephrine	130-143	adrenoceptor alpha 1B	Homo sapiens	32-61
26428673-0	2016	Resveratrol attenuates norepinephrine-induced ovarian cancer invasiveness through downregulating hTERT expression.	Norepinephrine	23-37	telomerase reverse transcriptase	Homo sapiens	97-102
26459348-7	2015	Treatment of mice housed at 22 C with a beta2-adrenergic antagonist reverses the norepinephrine-driven suppression of GVHD and yields similar disease to mice housed at 30 C. Conversely, administering a beta2-adrenergic agonist decreases GVHD in mice housed at 30 C. In further mechanistic studies using beta2-adrenergic receptor-deficient (beta2-AR(-/-)) mice, we found that it is host cell beta2-AR signaling that is essential for decreasing GVHD.	Norepinephrine	81-95	adrenergic receptor, beta 2	Mus musculus	303-328
26459348-7	2015	Treatment of mice housed at 22 C with a beta2-adrenergic antagonist reverses the norepinephrine-driven suppression of GVHD and yields similar disease to mice housed at 30 C. Conversely, administering a beta2-adrenergic agonist decreases GVHD in mice housed at 30 C. In further mechanistic studies using beta2-adrenergic receptor-deficient (beta2-AR(-/-)) mice, we found that it is host cell beta2-AR signaling that is essential for decreasing GVHD.	Norepinephrine	81-95	adrenergic receptor, beta 2	Mus musculus	340-348
26459348-7	2015	Treatment of mice housed at 22 C with a beta2-adrenergic antagonist reverses the norepinephrine-driven suppression of GVHD and yields similar disease to mice housed at 30 C. Conversely, administering a beta2-adrenergic agonist decreases GVHD in mice housed at 30 C. In further mechanistic studies using beta2-adrenergic receptor-deficient (beta2-AR(-/-)) mice, we found that it is host cell beta2-AR signaling that is essential for decreasing GVHD.	Norepinephrine	81-95	adrenergic receptor, beta 2	Mus musculus	391-399
20813157-8	2010	These results suggest that noradrenaline suppresses Cs-sensitive and TEA-insensitive potassium channels via the alpha(1B)-adrenergic receptor in human osteoblasts.	Norepinephrine	27-40	adrenoceptor alpha 1B	Homo sapiens	112-141
21046458-4	2010	Under basal conditions, VMAT1 is widely expressed in all adrenal chromaffin cells, while VMAT2 is co-localized with tyrosine hydroxylase (TH) but not phenylethanolamine N-methyltransferase (PNMT), indicating its expression in norepinephrine (NE)-, but not epinephrine (Epi)-synthesizing chromaffin cells.	Norepinephrine	226-240	solute carrier family 18 member A2	Rattus norvegicus	89-94
26492961-6	2015	This new molecule, by combining two distinct mechanisms of action, mu-opioid receptor agonism (MOR) and noradrenaline reuptake inhibition (NRI), introduces a new pharmacological class called MOR-NRI.	Norepinephrine	104-117	opioid receptor mu 1	Homo sapiens	191-194
26004513-8	2015	P2X1 receptors mediate the vasocontractile actions of ATP released as a neurotransmitter with noradrenaline (NA) from sympathetic perivascular nerves, and are located on the vascular smooth muscle adjacent to the nerve varicosities, the sites of neurotransmitter release.	Norepinephrine	94-107	purinergic receptor P2X 1	Homo sapiens	0-4
26058426-4	2015	Treatments with norepinephrine (beta2-adrenoreceptor agonist) in mice xenografted with human DU145 prostate cancer cells increased the metastatic potential of these cells.	Norepinephrine	16-30	adrenergic receptor, beta 2	Mus musculus	32-52
25162503-9	2015	The relaxant effect of p-NP on KCl-induced uterine contractions was inhibited by noradrenaline (p&lt;0.05) but not by propranolol (p&gt;0.05).	Norepinephrine	81-94	purine nucleoside phosphorylase	Rattus norvegicus	23-27
25336319-3	2015	Moreover, DBH, whose activity and levels are strongly controlled by the DBH gene, is a key enzyme in the conversion of dopamine (DA) to norepinephrine (NE) associated with excited behavior.	Norepinephrine	136-150	dopamine beta-hydroxylase	Homo sapiens	10-13
25336319-3	2015	Moreover, DBH, whose activity and levels are strongly controlled by the DBH gene, is a key enzyme in the conversion of dopamine (DA) to norepinephrine (NE) associated with excited behavior.	Norepinephrine	136-150	dopamine beta-hydroxylase	Homo sapiens	72-75
20679667-5	2010	Affected males in this family showed an inherited hemizygous deletion restricted to NDP and two immediately telomeric genes, monoamine oxidase-B (MAO-B) and monoamine oxidase-A (MAO-A), which encode closely related enzymes that metabolize biogenic amines including serotonin, dopamine, and norepinephrine.	Norepinephrine	290-304	monoamine oxidase B	Homo sapiens	125-144
20679667-5	2010	Affected males in this family showed an inherited hemizygous deletion restricted to NDP and two immediately telomeric genes, monoamine oxidase-B (MAO-B) and monoamine oxidase-A (MAO-A), which encode closely related enzymes that metabolize biogenic amines including serotonin, dopamine, and norepinephrine.	Norepinephrine	290-304	monoamine oxidase B	Homo sapiens	146-151
20485326-1	2010	Monoamine oxidases (MAO-A and MAO-B) have a key role in the degradation of amine neurotransmitters, such as dopamine, norepinephrine and serotonin.	Norepinephrine	118-132	monoamine oxidase B	Homo sapiens	30-35
19725917-6	2010	Pre-incubation of mesenteric arterioles with anti-TRPC1 and anti-TRPC3 antibodies significantly reduced norepinephrine-induced vasomotion and calcium influx.	Norepinephrine	104-118	transient receptor potential cation channel, subfamily C, member 1	Rattus norvegicus	50-55
23051576-4	2010	I present a case report of PLP showing good response to Milnacipran - a novel antidepressant (SNRI) with dual mechanism of action through serotonin and norepinephrine reuptake inhibition similar to TCAs.	Norepinephrine	152-166	proteolipid protein 1	Homo sapiens	27-30
20584925-4	2010	Since neurotransmitter deficiencies are thought to underlie depression, we examined neurotransmitter levels in Cplx2-/- mice and found a significant decrease in levels of noradrenaline and the serotonin metabolite 5-hydroxyindoleacetic acid in the hippocampus.	Norepinephrine	171-184	complexin 2	Mus musculus	111-116
20808911-1	2010	BACKGROUND: Catechol-O-methyltransferase (COMT) is a key enzyme responsible for the degradation of dopamine and norepinephrine.	Norepinephrine	112-126	catechol-O-methyltransferase	Mus musculus	12-40
25151968-0	2015	hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness.	Norepinephrine	15-29	telomerase reverse transcriptase	Homo sapiens	0-5
25151968-3	2015	We thus sought to determine whether the stress hormone norepinephrine (NE) could induce hTERT expression and subsequently ovarian cancer progression.	Norepinephrine	55-69	telomerase reverse transcriptase	Homo sapiens	88-93
20808911-1	2010	BACKGROUND: Catechol-O-methyltransferase (COMT) is a key enzyme responsible for the degradation of dopamine and norepinephrine.	Norepinephrine	112-126	catechol-O-methyltransferase	Mus musculus	42-46
20363235-5	2010	In addition, amitriptyline, nortriptyline and imipramine were substantially more potent in the inhibition of noradrenaline-induced intracellular Ca(2+) increases in HEK-293 cells expressing alpha(1A)- or a truncated version of alpha(1D)-adrenoceptors which traffics more efficiently towards the cell membrane than in cells expressing alpha(1B)-adrenoceptors.	Norepinephrine	109-122	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	190-198
20363235-7	2010	The differential affinities for these receptors indicate that the alpha(1)-adrenoceptor subtype which activation is most increased by the augmented noradrenaline availability resultant from the blockade of neuronal reuptake is the alpha(1B)-adrenoceptor.	Norepinephrine	148-161	adrenoceptor alpha 1B	Homo sapiens	231-253
27227082-7	2016	In urine, the thrombomodulin level correlated strongly with adrenaline (rho = 0.806) and noradrenaline (rho = 0.760) levels.	Norepinephrine	89-102	thrombomodulin	Homo sapiens	14-28
20331606-1	2010	BACKGROUND AND PURPOSE: The present study tested the hypothesis that selective caspase-3 (C-3) knock-out would regulate the contractile actions of noradrenaline (NA) in the dysfunction of adult rat ventricular myocytes (ARVMs) induced by sepsis.	Norepinephrine	147-160	complement C3	Rattus norvegicus	79-93
27227082-10	2016	Median concentrations of plasma noradrenaline and urinary adrenaline were higher after exposure to +10 C than to +30 C. Thus, further evidence of the association between thrombomodulin and catecholamines was gained in a physiologically relevant setting in humans.	Norepinephrine	32-45	thrombomodulin	Homo sapiens	170-184
25789868-11	2015	RESULTS: Adrenaline and noradrenaline correlated positively with syndecan-1 and thrombomodulin i.e., biomarkers reflecting endothelial damage (both p&lt;0.05).	Norepinephrine	24-37	thrombomodulin	Homo sapiens	80-94
20094056-10	2010	AM and nicardipine similarly stimulated plasma noradrenaline and renin activity.	Norepinephrine	47-60	adrenomedullin	Homo sapiens	0-2
20061033-0	2010	Noradrenaline reuptake inhibitors inhibit expression of chemokines IP-10 and RANTES and cell adhesion molecules VCAM-1 and ICAM-1 in the CNS following a systemic inflammatory challenge.	Norepinephrine	0-13	C-C motif chemokine ligand 5	Rattus norvegicus	77-83
20061033-0	2010	Noradrenaline reuptake inhibitors inhibit expression of chemokines IP-10 and RANTES and cell adhesion molecules VCAM-1 and ICAM-1 in the CNS following a systemic inflammatory challenge.	Norepinephrine	0-13	intercellular adhesion molecule 1	Rattus norvegicus	123-129
20537159-4	2010	RESULTS: The changes in CIpc accurately tracked the changes in CItd induced by volume expansion (bias, -0.20 +/- 0.63 L/min/m2) as well as by norepinephrine (bias, -0.05 +/- 0.74 L/min/m2).	Norepinephrine	142-156	CLOCK interacting pacemaker	Homo sapiens	24-28
20537159-5	2010	The changes in CIpc accurately detected an increase in CItd &gt;or= 15% induced by volume expansion and norepinephrine introduction/increase (area under ROC curves, 0.878 (0.736 to 0.960) and 0.924 (0.795 to 0.983), respectively; P &lt; 0.05 versus 0.500 for both).	Norepinephrine	104-118	CLOCK interacting pacemaker	Homo sapiens	15-19
20537159-8	2010	CONCLUSIONS: The CIpc was reliable and accurate for assessing the CI changes induced by volume expansion and norepinephrine.	Norepinephrine	109-123	CLOCK interacting pacemaker	Homo sapiens	17-21
20595783-0	2010	Noradrenaline induces clock gene Per1 mRNA expression in C6 glioma cells through beta(2)-adrenergic receptor coupled with protein kinase A - cAMP response element binding protein (PKA-CREB) and Src-tyrosine kinase - glycogen synthase kinase-3beta (Src-GSK-3beta).	Norepinephrine	0-13	cAMP responsive element binding protein 1	Homo sapiens	141-178
20595783-0	2010	Noradrenaline induces clock gene Per1 mRNA expression in C6 glioma cells through beta(2)-adrenergic receptor coupled with protein kinase A - cAMP response element binding protein (PKA-CREB) and Src-tyrosine kinase - glycogen synthase kinase-3beta (Src-GSK-3beta).	Norepinephrine	0-13	cAMP responsive element binding protein 1	Homo sapiens	184-188
19596829-11	2009	However, rats in the AHF+PP36 group demonstrated a 60% decrease in cardiac endothelial nitric oxide synthase (eNOS) protein expression, and a 56% reduction of myocardial norepinephrine release, when compared with the AHF group"s animals.	Norepinephrine	170-184	linker for activation of T cells	Rattus norvegicus	25-29
19500686-4	2009	We show that norepinephrine affects the production and release of Dr fimbriae in Afa/Dr DAEC WT-IH11128 bacteria.	Norepinephrine	13-27	AFA	Homo sapiens	81-84
19457096-4	2009	Interestingly, HIF-2alpha depleted MAH cells showed dramatically lower (5-12 times) levels of dopamine and noradrenaline compared with wild-type and scrambled controls, even in normoxia (21% O(2)).	Norepinephrine	107-120	endothelial PAS domain protein 1	Rattus norvegicus	15-25
24888991-2	2015	Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine in central neurons and thus is critically involved in maintaining the transformational homeostasis.	Norepinephrine	72-86	dopamine beta-hydroxylase	Homo sapiens	0-25
24888991-2	2015	Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine in central neurons and thus is critically involved in maintaining the transformational homeostasis.	Norepinephrine	72-86	dopamine beta-hydroxylase	Homo sapiens	27-30
25498793-6	2015	CCI also induced a norepinephrine-triggered nociception that was inhibited by an alpha-adrenoceptor antagonist, norepinephrine transporter block and monoamine oxidase inhibition.	Norepinephrine	19-33	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Mus musculus	112-138
25506603-9	2015	This review uses the major brain norepinephrine system as a model stress-response system to demonstrate how co-regulation by opposing pro-stress (corticotropin-releasing factor) and anti-stress (enkephalin) neuromodulators must be fine-tuned to produce an adaptive response to stress.	Norepinephrine	33-47	corticotropin releasing hormone	Homo sapiens	146-176
25478705-2	2015	In vitro, norepinephrine and epinephrine inhibit placental 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), which protects the fetus from F overexposure by inactivating it to cortisone (E).	Norepinephrine	10-24	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	59-114
25975715-10	2015	Reduced DBH expression would be consistent with decreased conversion of dopamine to noradrenaline and thus with a relative hypo-noradrenergic state in ADHD.	Norepinephrine	84-97	dopamine beta-hydroxylase	Homo sapiens	8-11
25326128-1	2014	RATIONALE: Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine in the central nervous system and peripherally.	Norepinephrine	83-97	dopamine beta-hydroxylase	Homo sapiens	11-36
25326128-1	2014	RATIONALE: Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine in the central nervous system and peripherally.	Norepinephrine	83-97	dopamine beta-hydroxylase	Homo sapiens	38-41
25317765-14	2014	This genomic region harbors monooxygenase dopamine beta-hydroxylase-like 1 gene (MOXD1), implicated in the biosynthesis of norepinephrine, which is prominently involved in cognitive functions.	Norepinephrine	123-137	monooxygenase DBH like 1	Homo sapiens	81-86
25179535-6	2014	Furthermore, the expression of the Notch ligand Jagged 1 was significantly upregulated by norepinephrine at both mRNA and protein levels in breast cancer cells.	Norepinephrine	90-104	jagged canonical Notch ligand 1	Homo sapiens	48-56
25179535-7	2014	Inhibitors of beta2-adrenergic receptor (beta2-AR), protein kinase A (PKA), and mTOR could reverse norepinephrine-induced Jagged 1 upregulation, indicating that the beta2-AR-PKA-mTOR pathway participates in this process.	Norepinephrine	99-113	jagged canonical Notch ligand 1	Homo sapiens	122-130
25179535-8	2014	Knockdown of Jagged 1 expression in breast cancer cells not only repressed norepinephrine-induced activation of the Notch pathway in cocultured endothelial cells but also evidently impaired the effects of norepinephrine on capillary-like sprout formation.	Norepinephrine	75-89	jagged canonical Notch ligand 1	Homo sapiens	13-21
19190077-9	2009	Most abdominal and thoracic SDHB-PGLs hypersecrete either norepinephrine or norepinephrine and dopamine.	Norepinephrine	58-72	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	28-32
19190077-9	2009	Most abdominal and thoracic SDHB-PGLs hypersecrete either norepinephrine or norepinephrine and dopamine.	Norepinephrine	76-90	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	28-32
25179535-8	2014	Knockdown of Jagged 1 expression in breast cancer cells not only repressed norepinephrine-induced activation of the Notch pathway in cocultured endothelial cells but also evidently impaired the effects of norepinephrine on capillary-like sprout formation.	Norepinephrine	205-219	jagged canonical Notch ligand 1	Homo sapiens	13-21
25179535-9	2014	These data demonstrate that tumor angiogenesis mediated by the Jagged 1/Notch intercellular signaling is governed by the norepinephrine-activated beta2-AR-PKA-mTOR pathway.	Norepinephrine	121-135	jagged canonical Notch ligand 1	Homo sapiens	63-71
19217831-7	2009	The peak values of IL-6 and IL-8 also correlated positively with the peak values of noradrenaline (r=0.603 and r=0.681, respectively).These results suggest that a pronounced activation of the sympathetic nervous system and the inflammatory response occurs in acute stage of SAH.	Norepinephrine	84-97	interleukin 6	Canis lupus familiaris	19-23
25187989-2	2014	In the current study we demonstrate that the noradrenalin analogue octopamine and the cholecystokinin (CCK) homologue Drosulfakinin (Dsk) function downstream of TfAP-2 and Tiwaz (Twz) to control the number of meals in adult flies.	Norepinephrine	45-57	Transcription factor AP-2	Drosophila melanogaster	161-167
19179649-7	2009	At 7 mo, alpha(2A)/alpha(2C)ARKO mice displayed exercise intolerance and increased muscular norepinephrine, muscular atrophy, capillary rarefaction, and increased oxidative stress.	Norepinephrine	92-106	adrenergic receptor, alpha 2c	Mus musculus	19-27
19452616-7	2009	Further, the results for choline acetyltransferase indicate that early depletion of norepinephrine compromises development of acetylcholine systems, consistent with a trophic role for this neurotransmitter.	Norepinephrine	84-98	choline O-acetyltransferase	Rattus norvegicus	25-50
25050919-7	2014	Importantly, pro-hypertrophic signalling pathways such as those driven by angiotensin II and norepinephrine also regulate miR-23a-miR-27a-miR-24-2 cluster proximal promoter activity.	Norepinephrine	93-107	microRNA 24-2	Homo sapiens	138-146
19212675-2	2009	By microarray expression analysis (Affymetrix HU133A) important players in the noradrenalin biosynthesis pathway (DBH, DDC, GATA2, GATA3, PHOX2A, PHOX2B, SLC6A2 SLC18A1 and TH) were found to be among the top ranked genes in showing lower expression in unfavorable NB tumor types as compared to favorable ones.	Norepinephrine	79-91	GATA binding protein 3	Homo sapiens	131-136
18923403-1	2009	The antidepressant desipramine inhibits the reuptake of norepinephrine (NE), leading to activation of both pre- and postsynaptic adrenergic receptors, including alpha-1, alpha-2, beta-1, and beta-2 subtypes.	Norepinephrine	56-70	hemoglobin, beta adult minor chain	Mus musculus	191-197
24951589-4	2014	The contractile responses of arteries from knock-out mice to norepinephrine were inhibited by Rho-associated kinase (ROCK) and protein kinase C inhibitors and were associated with inhibition of phosphorylation of the myosin light chain phosphatase inhibitor CPI-17.	Norepinephrine	61-75	protein phosphatase 1, regulatory inhibitor subunit 14A	Mus musculus	258-264
24657329-7	2014	All of the nine antidepressant compounds showed moderate inhibitory effects on OCT2-mediated metformin, serotonin and/or norepinephrine uptake.	Norepinephrine	121-135	solute carrier family 22 member 2	Homo sapiens	79-83
19059194-4	2009	Noradrenaline and the selective beta2-adrenoceptor agonists isoprenaline and salmeterol stimulated osteoclast formation and bone resorption in BM osteoblast co-cultures and increased expression of RANK-L by osteoblasts.	Norepinephrine	0-13	TNF superfamily member 11	Homo sapiens	197-203
24952646-8	2014	Under conditions of chronic variable stress in mice, sympathetic nerve fibers released surplus noradrenaline, which signaled bone marrow niche cells to decrease CXCL12 levels through the beta3-adrenergic receptor.	Norepinephrine	95-108	adrenergic receptor, beta 3	Mus musculus	187-212
18554250-1	2008	In the mammalian pineal gland, the rhythm in melatonin biosynthesis depends on the norepinephrine (NE)-driven regulation of arylalkylamine N-acetyltransferase (AANAT), the penultimate enzyme of melatonin biosynthesis.	Norepinephrine	83-97	aralkylamine N-acetyltransferase	Homo sapiens	124-158
18554250-1	2008	In the mammalian pineal gland, the rhythm in melatonin biosynthesis depends on the norepinephrine (NE)-driven regulation of arylalkylamine N-acetyltransferase (AANAT), the penultimate enzyme of melatonin biosynthesis.	Norepinephrine	83-97	aralkylamine N-acetyltransferase	Homo sapiens	160-165
19067837-7	2008	Expression of TLR-9 and TLR-11 in cells exposed to norepinephrine (NE) and parasites was significantly decreased when compared to cells exposed to parasites only.	Norepinephrine	51-65	toll-like receptor 9	Mus musculus	14-19
18762182-5	2008	Opposite effects were also observed in the expression of the transcription factor CREB with norepinephrine upregulating phosphorylated CREB (pCREB) levels, while dexamethasone downregulated CREB mRNA and protein levels, as well as pCREB levels.	Norepinephrine	92-106	cAMP responsive element binding protein 1	Homo sapiens	82-86
18762182-5	2008	Opposite effects were also observed in the expression of the transcription factor CREB with norepinephrine upregulating phosphorylated CREB (pCREB) levels, while dexamethasone downregulated CREB mRNA and protein levels, as well as pCREB levels.	Norepinephrine	92-106	cAMP responsive element binding protein 1	Homo sapiens	135-139
18762182-5	2008	Opposite effects were also observed in the expression of the transcription factor CREB with norepinephrine upregulating phosphorylated CREB (pCREB) levels, while dexamethasone downregulated CREB mRNA and protein levels, as well as pCREB levels.	Norepinephrine	92-106	cAMP responsive element binding protein 1	Homo sapiens	135-139
18840973-2	2008	They include transporters for norepinephrine, dopamine and serotonin, which are encoded by the SLC6A2, SLC6A3, and SLC6A4 genes, respectivily.	Norepinephrine	30-44	solute carrier family 6 member 2	Canis lupus familiaris	95-101
18338249-3	2008	GATA-3 robustly transactivates the promoter function of the noradrenaline (NA)-synthesizing DBH gene, via two specific upstream promoter domains; one at -62 to -32 bp and the other at -891 to -853 bp.	Norepinephrine	60-73	GATA binding protein 3	Homo sapiens	0-6
18620029-2	2008	In the present work we have studied in detail the regional and cellular localization of the dopamine D(4) receptor immunoreactivity (IR) in the rat cerebral cortex and its relationship to the dopaminergic and noradrenergic nerve terminal networks, since both dopamine and noradrenaline have a high affinity for this receptor.	Norepinephrine	272-285	dopamine receptor D4	Rattus norvegicus	92-114
18668589-10	2008	Culture of CD4+CD25+ cells with norepinephrine (10(-5)M) for 24 hours before transfer worsened the arthritis.	Norepinephrine	32-46	CD4 antigen	Mus musculus	11-14
18505450-8	2008	At 0.3, 1.0 and 3.0 nmol/animal, GLP-1 dose-dependently elevated plasma levels of noradrenaline and adrenaline and the 1.0 nmol GLP-1-induced response was dose-dependently reduced by 5 and 10 nmol/animal exendin (5-39), a selective GLP-1 receptor antagonist.	Norepinephrine	82-95	glucagon	Rattus norvegicus	33-38
18505450-14	2008	These results suggest that, in rats, centrally administered GLP-1 induces the secretion of adrenaline from the adrenal medulla by brain thromboxane A(2)-mediated mechanisms, whereas the peptide evokes the release of noradrenaline from sympathetic nerves by brain prostanoids via mechanisms other than those mediated by thromboxane A(2).	Norepinephrine	216-229	glucagon	Rattus norvegicus	60-65
18636164-6	2008	We also evaluated the ability of norepinephrine to induce interleukin-6 (IL-6), interleukin-10 (IL-10), and vascular endothelial growth factor (VEGF).	Norepinephrine	33-47	interleukin 10	Homo sapiens	80-94
18636164-6	2008	We also evaluated the ability of norepinephrine to induce interleukin-6 (IL-6), interleukin-10 (IL-10), and vascular endothelial growth factor (VEGF).	Norepinephrine	33-47	interleukin 10	Homo sapiens	96-101
18550369-1	2008	The design, synthesis, and SAR of a series of ring-constrained norepinephrine reuptake inhibitors are described.	Norepinephrine	63-77	sarcosine dehydrogenase	Homo sapiens	27-30
18577832-7	2008	The treatment of anti-HMGB1 mAb significantly increased the plasma troponin-T and norepinephrine (NE) content in the heart in comparison with the control (p&lt;0.05).	Norepinephrine	82-96	high mobility group box 1	Rattus norvegicus	22-27
18543980-3	2008	Here, we built structural models of human transporters of dopamine, norepinephrine, and serotonin using the LeuT structure.	Norepinephrine	68-82	Leucine transport, high	Homo sapiens	108-112
18387943-10	2008	Finally, we show that 1,2-dioleoyl-sn-glycerol mimics the effect of PMA to drive PKCdelta to caveolae and increase PKCdelta-Tyr(311) phosphorylation, whereas G protein-coupled receptor agonists such as norepinephrine and endothelin-1 do not.	Norepinephrine	202-216	protein kinase C, delta	Mus musculus	81-89
18387943-11	2008	These results suggest that norepinephrine and endothelin-1 increase 1,2-dioleoyl-sn-glycerol accumulation and activate PKCdelta exclusively in non-caveolae membranes.	Norepinephrine	27-41	protein kinase C, delta	Mus musculus	119-127
18485637-2	2008	Interaction of c-kit receptor with its ligand-SCF potent enhances the melanocytic melanogenesis, which can be repressed by norepinephrine (NE).	Norepinephrine	123-137	KIT ligand	Homo sapiens	46-49
21499463-13	2008	Propranolol treatment alone produced depression, and antagonized the effects of alprazolam and imipramine, even producing depression in combined treatments.In conclusion, our results reveal that alprazolam may produce antidepressant effects through the release of noradrenaline, which stimulates beta2 receptors to produce an antidepressant action.	Norepinephrine	264-277	hemoglobin, beta adult minor chain	Mus musculus	296-301
18403121-10	2008	Interestingly, 5-LOX deficiency and MK-886 treatment have been shown to be capable of increasing the behavioral effects of a noradrenaline/dopamine-potentiating drug, cocaine.	Norepinephrine	125-138	arachidonate 5-lipoxygenase	Mus musculus	15-20
25039112-0	2014	Effect of neuropeptide Y on norepinephrine-induced constriction in the rabbit facial artery after carotid artery occlusion.	Norepinephrine	28-42	neuropeptide Y	Oryctolagus cuniculus	10-24
24440144-0	2014	The sympathetic nervous system modulates CD4(+)Foxp3(+) regulatory T cells via noradrenaline-dependent apoptosis in a murine model of lymphoproliferative disease.	Norepinephrine	79-92	forkhead box P3	Mus musculus	47-52
24582917-7	2014	Systemic administration of norepinephrine reuptake inhibitor atomoxetine increased c-Fos protein expression in BLA neurons following fear conditioning training and promoted the expression of conditioned fear in resistant mice.	Norepinephrine	27-41	FBJ osteosarcoma oncogene	Mus musculus	83-88
24510409-1	2014	Monoamine oxidase A (MAOA) catalyzes monoamine neurotransmitters including dopamine, 5-hydroxytryptamine (5-HT, serotonin), and norepinephrine.	Norepinephrine	128-142	monoamine oxidase A	Homo sapiens	0-19
24323315-4	2014	METHODS AND RESULTS: Norepinephrine (NE) elevated contraction in endothelium-intact vessels in a dose-dependent manner, to a greater extent in DJ-1/park7 knockout (DJ-1/park7(-/-)) mice than in wild-type (DJ-1/park7(+/+)) mice.	Norepinephrine	21-35	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	143-153
24323315-4	2014	METHODS AND RESULTS: Norepinephrine (NE) elevated contraction in endothelium-intact vessels in a dose-dependent manner, to a greater extent in DJ-1/park7 knockout (DJ-1/park7(-/-)) mice than in wild-type (DJ-1/park7(+/+)) mice.	Norepinephrine	21-35	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	164-174
24323315-4	2014	METHODS AND RESULTS: Norepinephrine (NE) elevated contraction in endothelium-intact vessels in a dose-dependent manner, to a greater extent in DJ-1/park7 knockout (DJ-1/park7(-/-)) mice than in wild-type (DJ-1/park7(+/+)) mice.	Norepinephrine	21-35	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	164-174
24252179-2	2014	Based on our previous study showing that overexpression of wild-type or mutant alpha-synuclein (alpha-SYN) interferes with cAMP/PKA-dependent transcriptional activation in norepinephrine (NE)-producing cells, the effect of wild-type and mutant alpha-SYN on cAMP response element (CRE)-mediated regulation of the NE-synthesizing enzyme dopamine beta-hydroxylase (DBH) was evaluated in this study.	Norepinephrine	172-186	synuclein, alpha	Mus musculus	79-94
24252179-2	2014	Based on our previous study showing that overexpression of wild-type or mutant alpha-synuclein (alpha-SYN) interferes with cAMP/PKA-dependent transcriptional activation in norepinephrine (NE)-producing cells, the effect of wild-type and mutant alpha-SYN on cAMP response element (CRE)-mediated regulation of the NE-synthesizing enzyme dopamine beta-hydroxylase (DBH) was evaluated in this study.	Norepinephrine	172-186	synuclein, alpha	Mus musculus	96-105
24465756-4	2014	Since norepinephrine affects motility of EHEC O157:H7 through a qseBC-encoded two-component quorum sensing signaling, we also determined whether the hha-mediated regulation of motility is affected by norepinephrine and whether this effect is qseBC dependent.	Norepinephrine	200-214	H-HA	Escherichia coli	149-152
24391727-10	2013	Since dopamine beta-hydroxylase (DBH) catalyzes conversion of dopamine to norepinephrine, we studied functional variation at DBH; DBH promoter haplotypes predicted transcriptional activity (p&lt;0.001), plasma DBH (p&lt;0.0001) and norepinephrine (p = 0.0297) secretion; transcriptional activity was inversely (p&lt;0.0001) associated with basal eGFR.	Norepinephrine	74-88	dopamine beta-hydroxylase	Homo sapiens	6-31
24391727-10	2013	Since dopamine beta-hydroxylase (DBH) catalyzes conversion of dopamine to norepinephrine, we studied functional variation at DBH; DBH promoter haplotypes predicted transcriptional activity (p&lt;0.001), plasma DBH (p&lt;0.0001) and norepinephrine (p = 0.0297) secretion; transcriptional activity was inversely (p&lt;0.0001) associated with basal eGFR.	Norepinephrine	74-88	dopamine beta-hydroxylase	Homo sapiens	33-36
24391727-10	2013	Since dopamine beta-hydroxylase (DBH) catalyzes conversion of dopamine to norepinephrine, we studied functional variation at DBH; DBH promoter haplotypes predicted transcriptional activity (p&lt;0.001), plasma DBH (p&lt;0.0001) and norepinephrine (p = 0.0297) secretion; transcriptional activity was inversely (p&lt;0.0001) associated with basal eGFR.	Norepinephrine	74-88	dopamine beta-hydroxylase	Homo sapiens	125-128
24391727-10	2013	Since dopamine beta-hydroxylase (DBH) catalyzes conversion of dopamine to norepinephrine, we studied functional variation at DBH; DBH promoter haplotypes predicted transcriptional activity (p&lt;0.001), plasma DBH (p&lt;0.0001) and norepinephrine (p = 0.0297) secretion; transcriptional activity was inversely (p&lt;0.0001) associated with basal eGFR.	Norepinephrine	74-88	dopamine beta-hydroxylase	Homo sapiens	125-128
24391727-10	2013	Since dopamine beta-hydroxylase (DBH) catalyzes conversion of dopamine to norepinephrine, we studied functional variation at DBH; DBH promoter haplotypes predicted transcriptional activity (p&lt;0.001), plasma DBH (p&lt;0.0001) and norepinephrine (p = 0.0297) secretion; transcriptional activity was inversely (p&lt;0.0001) associated with basal eGFR.	Norepinephrine	74-88	dopamine beta-hydroxylase	Homo sapiens	125-128
24391727-10	2013	Since dopamine beta-hydroxylase (DBH) catalyzes conversion of dopamine to norepinephrine, we studied functional variation at DBH; DBH promoter haplotypes predicted transcriptional activity (p&lt;0.001), plasma DBH (p&lt;0.0001) and norepinephrine (p = 0.0297) secretion; transcriptional activity was inversely (p&lt;0.0001) associated with basal eGFR.	Norepinephrine	232-246	dopamine beta-hydroxylase	Homo sapiens	6-31
24391727-10	2013	Since dopamine beta-hydroxylase (DBH) catalyzes conversion of dopamine to norepinephrine, we studied functional variation at DBH; DBH promoter haplotypes predicted transcriptional activity (p&lt;0.001), plasma DBH (p&lt;0.0001) and norepinephrine (p = 0.0297) secretion; transcriptional activity was inversely (p&lt;0.0001) associated with basal eGFR.	Norepinephrine	232-246	dopamine beta-hydroxylase	Homo sapiens	33-36
24391727-10	2013	Since dopamine beta-hydroxylase (DBH) catalyzes conversion of dopamine to norepinephrine, we studied functional variation at DBH; DBH promoter haplotypes predicted transcriptional activity (p&lt;0.001), plasma DBH (p&lt;0.0001) and norepinephrine (p = 0.0297) secretion; transcriptional activity was inversely (p&lt;0.0001) associated with basal eGFR.	Norepinephrine	232-246	dopamine beta-hydroxylase	Homo sapiens	125-128
24391727-10	2013	Since dopamine beta-hydroxylase (DBH) catalyzes conversion of dopamine to norepinephrine, we studied functional variation at DBH; DBH promoter haplotypes predicted transcriptional activity (p&lt;0.001), plasma DBH (p&lt;0.0001) and norepinephrine (p = 0.0297) secretion; transcriptional activity was inversely (p&lt;0.0001) associated with basal eGFR.	Norepinephrine	232-246	dopamine beta-hydroxylase	Homo sapiens	125-128
24391727-10	2013	Since dopamine beta-hydroxylase (DBH) catalyzes conversion of dopamine to norepinephrine, we studied functional variation at DBH; DBH promoter haplotypes predicted transcriptional activity (p&lt;0.001), plasma DBH (p&lt;0.0001) and norepinephrine (p = 0.0297) secretion; transcriptional activity was inversely (p&lt;0.0001) associated with basal eGFR.	Norepinephrine	232-246	dopamine beta-hydroxylase	Homo sapiens	125-128
24075956-1	2013	Uptake of norepinephrine via the neuronal norepinephrine transporter is reduced in the heart during deoxycorticosterone (DOCA)-salt hypertension.	Norepinephrine	10-24	solute carrier family 6 member 2	Rattus norvegicus	42-68
23906995-1	2013	OBJECTIVE: Dopamine-beta-hydroxylase (DBH) metabolizes the conversion of dopamine to noradrenaline.	Norepinephrine	85-98	dopamine beta-hydroxylase	Homo sapiens	11-36
23906995-1	2013	OBJECTIVE: Dopamine-beta-hydroxylase (DBH) metabolizes the conversion of dopamine to noradrenaline.	Norepinephrine	85-98	dopamine beta-hydroxylase	Homo sapiens	38-41
18177483-0	2008	Chronic noradrenaline increases renal expression of NHE-3, NBC-1, BSC-1 and aquaporin-2.	Norepinephrine	8-21	solute carrier family 12 member 1	Rattus norvegicus	66-71
18177483-13	2008	We conclude that noradrenaline-induced increases in the expression of NHE-3, NBC-1, BSC-1 and aquaporin-2 are likely to play an important role in the regulation of salt and water transport by noradrenaline in the kidney and may explain, at least in part, the altered renal sodium and water handling associated with overactivation of the sympathetic system.	Norepinephrine	17-30	solute carrier family 12 member 1	Rattus norvegicus	84-89
18300261-1	2008	The alpha(2A)-adrenoceptor (AR) subtype, a G protein-coupled receptor located both pre- and postsynaptically, mediates adrenaline/noradrenaline functions.	Norepinephrine	130-143	adrenoceptor alpha 2A	Danio rerio	4-26
24005671-0	2013	Extracellular norepinephrine clearance by the norepinephrine transporter is required for skeletal homeostasis.	Norepinephrine	14-28	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Mus musculus	46-72
18300261-1	2008	The alpha(2A)-adrenoceptor (AR) subtype, a G protein-coupled receptor located both pre- and postsynaptically, mediates adrenaline/noradrenaline functions.	Norepinephrine	130-143	adrenoceptor alpha 2A	Danio rerio	28-30
18193048-1	2008	Morphine, a powerful analgesic, and norepinephrine, the principal neurotransmitter of sympathetic nerves, exert major inhibitory effects on both peripheral and brain neurons by activating distinct cell-surface G protein-coupled receptors-the mu-opioid receptor (MOR) and alpha2A-adrenergic receptor (alpha2A-AR), respectively.	Norepinephrine	36-50	adrenoceptor alpha 2A	Homo sapiens	271-298
18193048-1	2008	Morphine, a powerful analgesic, and norepinephrine, the principal neurotransmitter of sympathetic nerves, exert major inhibitory effects on both peripheral and brain neurons by activating distinct cell-surface G protein-coupled receptors-the mu-opioid receptor (MOR) and alpha2A-adrenergic receptor (alpha2A-AR), respectively.	Norepinephrine	36-50	adrenoceptor alpha 2A	Homo sapiens	300-310
24205443-2	2013	In drug-free patients, CSF levels of the metabolites of noradrenaline (MHPG), serotonin (5-HIAA), and dopamine (HVA), neurotransmitters involved in eating behavior, were estimated in searching for associations with body mass index (BMI).	Norepinephrine	56-69	colony stimulating factor 2	Homo sapiens	23-26
18193048-4	2008	We discovered that morphine binding to the MOR triggers a conformational change in the norepinephrine-occupied alpha2A-AR that inhibits its signaling to G(i) and the downstream MAP kinase cascade.	Norepinephrine	87-101	adrenoceptor alpha 2A	Homo sapiens	111-121
17056037-6	2006	Neurotensin produced a marked increase in coronary effluent norepinephrine release, an effect abolished by SR 48692, a specific neurotensin receptor antagonist.	Norepinephrine	60-74	neurotensin	Rattus norvegicus	0-11
23714242-10	2013	Current study suggests that norepinephrine inhibits synthesis of Bcl-2 and increases Bax and apoptosis of cardiomyocytes.	Norepinephrine	28-42	BCL2 associated X, apoptosis regulator	Rattus norvegicus	85-88
17056037-6	2006	Neurotensin produced a marked increase in coronary effluent norepinephrine release, an effect abolished by SR 48692, a specific neurotensin receptor antagonist.	Norepinephrine	60-74	neurotensin	Rattus norvegicus	128-139
17056037-9	2006	In conclusion, these data indicate that following chronic beta-adrenoceptor activation, neurotensin-induced effects on norepinephrine release and subsequent contractile changes are markedly down-regulated.	Norepinephrine	119-133	neurotensin	Rattus norvegicus	88-99
16973367-2	2006	Efforts to design selective norepinephrine reuptake inhibitors based on SAR from the aryloxypropanamine series of monoamine reuptake inhibitors have led to the identification of a potent new class of dual acting norepinephrine and serotonin reuptake inhibitors, namely the 3-(1H-indol-1-yl)-3-arylpropan-1-amines.	Norepinephrine	28-42	sarcosine dehydrogenase	Homo sapiens	72-75
16973367-2	2006	Efforts to design selective norepinephrine reuptake inhibitors based on SAR from the aryloxypropanamine series of monoamine reuptake inhibitors have led to the identification of a potent new class of dual acting norepinephrine and serotonin reuptake inhibitors, namely the 3-(1H-indol-1-yl)-3-arylpropan-1-amines.	Norepinephrine	212-226	sarcosine dehydrogenase	Homo sapiens	72-75
17205149-5	2006	Factors such as leptin inducible factors (for example, noradrenaline), that regulate the activity of profibrogenic cytokines, such as IL-10 and TGF-beta, dictate the extent of fibrosis that occurs during liver injury.	Norepinephrine	55-68	interleukin 10	Homo sapiens	134-139
16556729-8	2006	However, the excretion of epinephrine, norepinephrine, and dopamine was significantly elevated in the Chga null mutants.	Norepinephrine	39-53	chromogranin A	Mus musculus	102-106
23845478-1	2013	Norepinephrine (NE) is detected amperometrically using the enzyme Phenylethanolamine N-methyl transferase and cofactor S-(5"-Adenosyl)-l-methionine chloride dihydrochloride with disposable screen printed mesoporous carbon electrodes.	Norepinephrine	0-14	phenylethanolamine N-methyltransferase	Oryctolagus cuniculus	66-105
16822586-1	2006	CART is expressed abundantly in the hypothalamic paraventricular nucleus and locus coeruleus, major corticotropin releasing factor (CRF) and noradrenaline sources, respectively.	Norepinephrine	141-154	CART prepropeptide	Rattus norvegicus	0-4
23384717-1	2013	OBJECTIVES: Dopamine-beta-hydroxylase (DBH) is the enzyme responsible for the conversion of dopamine (DA) to norepinephrine (NE, noradrenaline) which is a key neurotransmitter in the central and peripheral nervous systems.	Norepinephrine	109-123	dopamine beta-hydroxylase	Homo sapiens	12-37
23384717-1	2013	OBJECTIVES: Dopamine-beta-hydroxylase (DBH) is the enzyme responsible for the conversion of dopamine (DA) to norepinephrine (NE, noradrenaline) which is a key neurotransmitter in the central and peripheral nervous systems.	Norepinephrine	109-123	dopamine beta-hydroxylase	Homo sapiens	39-42
23384717-1	2013	OBJECTIVES: Dopamine-beta-hydroxylase (DBH) is the enzyme responsible for the conversion of dopamine (DA) to norepinephrine (NE, noradrenaline) which is a key neurotransmitter in the central and peripheral nervous systems.	Norepinephrine	129-142	dopamine beta-hydroxylase	Homo sapiens	12-37
23384717-1	2013	OBJECTIVES: Dopamine-beta-hydroxylase (DBH) is the enzyme responsible for the conversion of dopamine (DA) to norepinephrine (NE, noradrenaline) which is a key neurotransmitter in the central and peripheral nervous systems.	Norepinephrine	129-142	dopamine beta-hydroxylase	Homo sapiens	39-42
23539726-12	2013	CONCLUSION: This case represents the first association of a somatic HIF2A gain-of-function mutation with PHEO and congenital polycythemia, and it alerts physicians to perform proper genetic screening in patients presenting with multiple norepinephrine-producing PHEOs and polycythemia.	Norepinephrine	237-251	endothelial PAS domain protein 1	Homo sapiens	68-73
23510745-1	2013	By balancing the ratios of dopamine and norepinephrine, dopamine beta hydroxylase (DBH) plays an important role in brain reward circuit that is involved with behavioral effects of heroin addiction.	Norepinephrine	40-54	dopamine beta-hydroxylase	Homo sapiens	56-81
23510745-1	2013	By balancing the ratios of dopamine and norepinephrine, dopamine beta hydroxylase (DBH) plays an important role in brain reward circuit that is involved with behavioral effects of heroin addiction.	Norepinephrine	40-54	dopamine beta-hydroxylase	Homo sapiens	83-86
23478410-6	2013	Moreover, HSPC motility was regulated by norepinephrine and insulin-like growth factor-1 (IGF-1), which increased or reduced, respectively, GSK3beta expression in BM HSPCs and their subsequent egress.	Norepinephrine	41-55	glycogen synthase kinase 3 beta	Mus musculus	140-148
16449297-4	2006	Baseline epinephrine and glucagon were similar, and norepinephrine was elevated, in CRH KO vs. WT mice.	Norepinephrine	52-66	corticotropin releasing hormone	Mus musculus	84-87
16449297-10	2006	However, Prior Hypo CRH KO mice had significantly lower day 2 epinephrine and norepinephrine vs.	Norepinephrine	78-92	corticotropin releasing hormone	Mus musculus	20-23
16569708-2	2006	Although inactive in itself, the neuropeptide corticotropin releasing factor (CRF) strongly amplified the effect of BDNF, increasing the number of cells expressing TH and the active accumulation of noradrenaline by a factor of 2 to 3 via a mechanism that was nonmitogenic.	Norepinephrine	198-211	brain derived neurotrophic factor	Homo sapiens	116-120
16585966-0	2006	Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion.	Norepinephrine	70-84	renin	Cavia porcellus	26-31
16585966-4	2006	Local generation of cardiac Ang II from mast cell-derived renin also elicited norepinephrine release from isolated sympathetic nerve terminals.	Norepinephrine	78-92	renin	Cavia porcellus	58-63
16585966-11	2006	Thus, mast cell-derived renin is pivotal for activating a cardiac renin-angiotensin system leading to excessive norepinephrine release in ischemia/reperfusion.	Norepinephrine	112-126	renin	Cavia porcellus	24-29
16585966-11	2006	Thus, mast cell-derived renin is pivotal for activating a cardiac renin-angiotensin system leading to excessive norepinephrine release in ischemia/reperfusion.	Norepinephrine	112-126	renin	Cavia porcellus	66-71
16515684-2	2006	The transporters for the monoamines dopamine, norepinephrine, and serotonin (DAT, NET, and SERT) are targets for several popular psychostimulant drugs of abuse.	Norepinephrine	46-60	solute carrier family 6 member 3	Homo sapiens	77-80
16428474-12	2006	Norepinephrine also increased tumor cell expression of MMP-2 (P = 0.02 for both SKOV3 and EG cells) and MMP-9 (P = 0.01 and 0.04, respectively), and pharmacologic blockade of MMPs abrogated the effects of norepinephrine on tumor cell invasive potential.	Norepinephrine	0-14	matrix metallopeptidase 9	Homo sapiens	104-109
16210849-1	2006	Beta-adrenergic receptor (betaAR) activation has been shown to maintain heart rate during hypoxia and to rescue the fetus from the fetal lethality that occurs in the absence of norepinephrine.	Norepinephrine	177-191	adrenergic receptor, beta 1	Mus musculus	26-32
17073682-3	2006	The fact that all three monoamine (dopamine, norepinephrine, and serotonin) transporters (DAT, NET and SERT) are involved in various neurological and psychiatric diseases further emphasizes the need to develop suitable NET ligands so that researchers will be able to probe the contributions of each monoamine transporter system to specific CNS disorders.	Norepinephrine	45-59	solute carrier family 6 member 3	Homo sapiens	90-93
16102757-6	2006	The affinity of the beta2-adrenoceptor for isoprenaline and adrenaline (beta2-values of 8.3 and 7.9) was clearly higher than for noradrenaline (beta2-value of 6.5).	Norepinephrine	129-142	beta-2 adrenergic receptor	Oncorhynchus mykiss	20-38
16722229-3	2006	Cotransport in norepinephrine (NET), epinephrine (EpiT), dopamine (DAT), and serotonin (SERT) transporters couples downhill Na+ flux to uphill transmitter flux.	Norepinephrine	15-29	solute carrier family 6 member 3	Homo sapiens	67-70
16722235-11	2006	The TEs of OCT1 and OCT2 for dopamine, noradrenaline, adrenaline and 5-HT in general are rather low, in the range relative to MPP+ of 5%-15%.	Norepinephrine	39-52	solute carrier family 22 member 1	Rattus norvegicus	11-15
16368196-5	2006	Furthermore the same dose of N-methyl-D-aspartic acid induced a significant increase in cyclic GMP for 30 min (P&lt;0.05), as well as in acetylcholine (P&lt;0.001) and norepinephrine for 15 min (P&lt;0.001).	Norepinephrine	168-182	5'-nucleotidase, cytosolic II	Homo sapiens	95-98
16368196-8	2006	These results suggested that nitric oxide release in the LDT induced by activation of the N-methyl-D-aspartic acid receptor on the cholinergic neurons of the LDT, then through the cyclic GMP system, facilitates norepinephrine release from the terminals of noradrenergic neurons in the locus coeruleus.	Norepinephrine	211-225	5'-nucleotidase, cytosolic II	Homo sapiens	187-190
16479149-2	2006	The accessory beta(3) subunits of Ca(2+) channels (Ca(V)beta(3)) are preferentially associated with the alpha(1B) subunit to form N-type Ca(2+) channels, and are therefore expected to play a functional role in the stimulation-evoked release of noradrenaline.	Norepinephrine	244-257	calcium channel, voltage-dependent, N type, alpha 1B subunit	Mus musculus	104-112
16140489-10	2005	However, during early development, when the chromaffin cells are actively dividing and during aging, when the adrenal medullary cells are known to show hyperplastic lesions, ATP acting through P2Y2 receptors may be involved in other physiological activities, such as proliferation and/or differentiation of the chromaffin cells associated with their adrenaline or noradrenaline phenotype.	Norepinephrine	364-377	purinergic receptor P2Y2	Rattus norvegicus	193-197
23469282-6	2013	Here, we examined the expression profile of the HDAC protein family from HDAC1 to HDAC11 in corticotropin-releasing hormone, oxytocin, vasopressin, agouti-related peptide (AgRP), pro-opiomelanocortin (POMC), orexin, histamine, dopamine, serotonin, and noradrenaline neurons.	Norepinephrine	252-265	histone deacetylase 11	Homo sapiens	82-88
22999823-6	2012	Labeling for dopamine-beta-hydroxylase (DBH; the enzyme involved in norepinephrine synthesis) in the ventromedial nucleus of the hypothalamus (VMH) was densest in females that acquired nest sites compared to spring-like females without nest sites or fall-like females.	Norepinephrine	68-82	dopamine beta-hydroxylase	Sturnus vulgaris	13-38
22999823-6	2012	Labeling for dopamine-beta-hydroxylase (DBH; the enzyme involved in norepinephrine synthesis) in the ventromedial nucleus of the hypothalamus (VMH) was densest in females that acquired nest sites compared to spring-like females without nest sites or fall-like females.	Norepinephrine	68-82	dopamine beta-hydroxylase	Sturnus vulgaris	40-43
22964465-0	2012	Involvement of presynaptic voltage-dependent Kv3 channel in endothelin-1-induced inhibition of noradrenaline release from rat gastric sympathetic nerves.	Norepinephrine	95-108	potassium voltage-gated channel subfamily A member 3	Rattus norvegicus	45-48
22837346-1	2012	Norepinephrine (NE) amplifies the mitogenic effect of EGF in a rat liver through the adrenergic receptor coupled with G protein, Ghalpha.	Norepinephrine	0-14	epidermal growth factor	Rattus norvegicus	54-57
22761303-3	2012	Because excessive norepinephrine release in the heart is a pivotal arrhythmogenic mechanism, we hypothesized that neuronal ALDH2 activation might diminish ischemic norepinephrine release.	Norepinephrine	18-32	aldehyde dehydrogenase 2 family member	Rattus norvegicus	123-128
22761303-3	2012	Because excessive norepinephrine release in the heart is a pivotal arrhythmogenic mechanism, we hypothesized that neuronal ALDH2 activation might diminish ischemic norepinephrine release.	Norepinephrine	164-178	aldehyde dehydrogenase 2 family member	Rattus norvegicus	123-128
23205094-5	2012	Epinephrine, norepinephrine and isoproterenol increased the cellular proliferation of the rat OS cell line COS1NR and rat MSCs in a dose-dependent and beta2AR antagonist-sensitive manner.	Norepinephrine	13-27	adrenoceptor beta 2	Rattus norvegicus	151-158
23675273-1	2012	Dopoamine-beta-hydroxylase (DBH) is a catecholamine-synthesizing enzyme which catalyzes the formation of norepinephrine from dopamine.	Norepinephrine	105-119	dopamine beta-hydroxylase	Rattus norvegicus	0-26
23675273-1	2012	Dopoamine-beta-hydroxylase (DBH) is a catecholamine-synthesizing enzyme which catalyzes the formation of norepinephrine from dopamine.	Norepinephrine	105-119	dopamine beta-hydroxylase	Rattus norvegicus	28-31
21973085-6	2012	Similarly, in 3-month-old mice, caveolin-1 KO reduced contractility to noradrenaline by an L-NNA-sensitive mechanism.	Norepinephrine	71-84	caveolin 1, caveolae protein	Mus musculus	32-42
16083857-1	2005	The human sulfotransferase, SULT1A3, catalyzes specifically the sulfonation of monoamines such as dopamine, epinephrine, and norepinephrine.	Norepinephrine	125-139	sulfotransferase family 1A member 3	Homo sapiens	28-35
15894566-9	2005	Notably, rAdv.heNOS decreased plasma levels of norepinephrine and plasma renin activity in cold-exposed rats, which suggests that eNOS gene transfer may decrease the activities of the sympathetic nervous system and the renin-angiotensin system.	Norepinephrine	47-61	nitric oxide synthase 3	Rattus norvegicus	15-19
15993437-1	2005	We have previously shown that dimethylphenylpiperazinium (DMPP) increases the release of noradrenaline (NA) from rat hippocampal slices via two distinct mechanisms: a nicotinic acetylcholine receptor (nAChR)-mediated exocytosis and a carrier-mediated release induced by the reversal of NA transporters.	Norepinephrine	89-102	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	167-199
15993437-1	2005	We have previously shown that dimethylphenylpiperazinium (DMPP) increases the release of noradrenaline (NA) from rat hippocampal slices via two distinct mechanisms: a nicotinic acetylcholine receptor (nAChR)-mediated exocytosis and a carrier-mediated release induced by the reversal of NA transporters.	Norepinephrine	89-102	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	201-206
16141665-7	2005	Norepinephrine (NE, 10 microM) stimulated the redistribution of RhoA from the cytosolic to the membrane fraction in swine pulmonary artery smooth muscle.	Norepinephrine	0-14	ras homolog family member A	Sus scrofa	64-68
15845618-7	2005	These results indicate that TRalpha is necessary for T(3) to modulate the central control of T(C) and for an essential step in norepinephrine activation of BAT thermogenesis but not to sustain obligatory thermogenesis.	Norepinephrine	127-141	guanine nucleotide binding protein, alpha transducing 1	Mus musculus	28-35
15911163-1	2005	The alpha2A and alpha2C adrenergic receptor (AR) subtypes mediate antinociception when activated by the endogenous ligand norepinephrine.	Norepinephrine	122-136	adrenergic receptor, alpha 2c	Mus musculus	16-43
15665039-0	2005	Alpha1- and beta1-adrenoceptor signaling fully compensates for beta3-adrenoceptor deficiency in brown adipocyte norepinephrine-stimulated glucose uptake.	Norepinephrine	112-126	adrenergic receptor, beta 1	Mus musculus	12-30
22513716-2	2012	Dopamine beta hydroxylase (DBH) is an enzyme that catalyses the conversion of dopamine into noradrenaline.	Norepinephrine	92-105	dopamine beta-hydroxylase	Homo sapiens	0-25
22513716-2	2012	Dopamine beta hydroxylase (DBH) is an enzyme that catalyses the conversion of dopamine into noradrenaline.	Norepinephrine	92-105	dopamine beta-hydroxylase	Homo sapiens	27-30
22538810-1	2012	Parathyroid hormone (PTH), the major calcium-regulating hormone, and norepinephrine (NE), the principal neurotransmitter of sympathetic nerves, regulate bone remodeling by activating distinct cell-surface G protein-coupled receptors in osteoblasts: the parathyroid hormone type 1 receptor (PTHR) and the beta(2)-adrenergic receptor (beta(2)AR), respectively.	Norepinephrine	69-83	adrenergic receptor, beta 2	Mus musculus	304-331
22538810-1	2012	Parathyroid hormone (PTH), the major calcium-regulating hormone, and norepinephrine (NE), the principal neurotransmitter of sympathetic nerves, regulate bone remodeling by activating distinct cell-surface G protein-coupled receptors in osteoblasts: the parathyroid hormone type 1 receptor (PTHR) and the beta(2)-adrenergic receptor (beta(2)AR), respectively.	Norepinephrine	69-83	adrenergic receptor, beta 2	Mus musculus	333-342
15763132-1	2005	Pre-synaptic norepinephrine (NE) and dopamine (DA) transporters (NET and DAT) terminate catecholamine synaptic transmission through reuptake of released neurotransmitter.	Norepinephrine	13-27	solute carrier family 6 member 3	Homo sapiens	73-76
21729140-1	2012	Neuropeptide Y (NPY) has been shown to induce contraction of isolated human penile erectile tissue and potentiate the response to noradrenaline.	Norepinephrine	130-143	neuropeptide Y	Homo sapiens	0-20
15763138-3	2005	We investigated whether substrates (dopamine, norepinephrine) of the human dopamine (hDAT) and norepinephrine (hNET) transporters can directly induce c-Fos protein in HEK-293 (HEK) cells transfected with the hDAT and hNET and whether PKC modulators affect this process.	Norepinephrine	46-60	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	150-155
15763138-4	2005	Dopamine and norepinephrine robustly induced c-Fos immunofluorescence in both hDAT and hNET cells, but not in untransfected HEK-293 cells, demonstrating that catecholamine-induced c-Fos induction was DAT- and NET-dependent.	Norepinephrine	13-27	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	45-50
21965192-4	2012	Since both noradrenaline and corticosterone are known to quickly affect properties of AMPA-type glutamate receptors (AMPAR), we here examined - in hippocampal neurons - three parameters which give insight in the functionality of AMPARs: phosphorylation, surface expression and spontaneous synaptic transmission.	Norepinephrine	11-24	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	229-235
15763138-4	2005	Dopamine and norepinephrine robustly induced c-Fos immunofluorescence in both hDAT and hNET cells, but not in untransfected HEK-293 cells, demonstrating that catecholamine-induced c-Fos induction was DAT- and NET-dependent.	Norepinephrine	13-27	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	180-185
15763138-4	2005	Dopamine and norepinephrine robustly induced c-Fos immunofluorescence in both hDAT and hNET cells, but not in untransfected HEK-293 cells, demonstrating that catecholamine-induced c-Fos induction was DAT- and NET-dependent.	Norepinephrine	13-27	solute carrier family 6 member 3	Homo sapiens	79-82
15763138-7	2005	BIS pretreatment abolished norepinephrine-induced c-Fos expression hNET but not dopamine-induced c-Fos induction in hDAT cells.	Norepinephrine	27-41	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	50-55
15763138-8	2005	In conclusion, induction of c-Fos by dopamine and norepinephrine requires the presence of hDAT and hNET but the contributions of hDAT and hNET to c-Fos induction is distinguishable on the basis of differing responses to a PKC inhibitor.	Norepinephrine	50-64	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	28-33
15725340-7	2005	Therefore, corticosterone potentiates noradrenaline-induced melatonin and NAS production through GR inhibition of NFkappaB nuclear translocation.	Norepinephrine	38-51	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	97-99
22093159-10	2012	Up-regulation of the sympathetic repellent semaphorin 3F in the polyps possibly triggers sympathetic repulsion and polyp growth due to the loss of anti-proliferative noradrenaline and presence of SP from local SP+ cells.	Norepinephrine	166-179	semaphorin 3F	Homo sapiens	43-56
15741322-5	2005	Normally, this division projects noradrenergic efferents to the cortex that appear to be diminished in Ear2-/- since the cortical concentration of noradrenaline is four times lower in these mice.	Norepinephrine	147-160	eosinophil-associated, ribonuclease A family, member 2	Mus musculus	103-107
20641715-8	2004	In noradrenergic neurons, dopamine is converted to norepinephrine (NE) by dopamine beta-hydroxylase (DBH) and stored in vesicles in the neurons (4).	Norepinephrine	51-65	dopamine beta-hydroxylase	Homo sapiens	74-99
20641715-8	2004	In noradrenergic neurons, dopamine is converted to norepinephrine (NE) by dopamine beta-hydroxylase (DBH) and stored in vesicles in the neurons (4).	Norepinephrine	51-65	dopamine beta-hydroxylase	Homo sapiens	101-104
22172866-1	2011	INTRODUCTION: Renalase, an enzyme that breaks down catecholamines like adrenaline and noradrenaline in the blood circulation, was discovered in 2005.	Norepinephrine	86-99	renalase, FAD dependent amine oxidase	Homo sapiens	14-22
21963947-1	2011	Having previously observed that noradrenaline activation of beta adrenergic receptors induces the synthesis of the chemokine monocyte chemoattractant protein (CCL2/MCP-1) in astrocytes, it is our interest to analyze the mechanisms involved in this process, particularly the possible effect of noradrenaline-modulating drugs.	Norepinephrine	32-45	C-C motif chemokine ligand 2	Rattus norvegicus	159-163
21963947-1	2011	Having previously observed that noradrenaline activation of beta adrenergic receptors induces the synthesis of the chemokine monocyte chemoattractant protein (CCL2/MCP-1) in astrocytes, it is our interest to analyze the mechanisms involved in this process, particularly the possible effect of noradrenaline-modulating drugs.	Norepinephrine	32-45	C-C motif chemokine ligand 2	Rattus norvegicus	164-169
21963947-1	2011	Having previously observed that noradrenaline activation of beta adrenergic receptors induces the synthesis of the chemokine monocyte chemoattractant protein (CCL2/MCP-1) in astrocytes, it is our interest to analyze the mechanisms involved in this process, particularly the possible effect of noradrenaline-modulating drugs.	Norepinephrine	293-306	C-C motif chemokine ligand 2	Rattus norvegicus	159-163
21963947-1	2011	Having previously observed that noradrenaline activation of beta adrenergic receptors induces the synthesis of the chemokine monocyte chemoattractant protein (CCL2/MCP-1) in astrocytes, it is our interest to analyze the mechanisms involved in this process, particularly the possible effect of noradrenaline-modulating drugs.	Norepinephrine	293-306	C-C motif chemokine ligand 2	Rattus norvegicus	164-169
21963947-6	2011	While the activation of beta adrenergic receptors and the subsequent elevation of cAMP levels seem to be the main pathway for noradrenaline to induce CCL2/MCP-1 in astrocytes, our data indicate that the alpha2 adrenergic receptors also regulate CCL2/MCP-1 expression working as inhibitory mediators.	Norepinephrine	126-139	C-C motif chemokine ligand 2	Rattus norvegicus	150-154
21963947-6	2011	While the activation of beta adrenergic receptors and the subsequent elevation of cAMP levels seem to be the main pathway for noradrenaline to induce CCL2/MCP-1 in astrocytes, our data indicate that the alpha2 adrenergic receptors also regulate CCL2/MCP-1 expression working as inhibitory mediators.	Norepinephrine	126-139	C-C motif chemokine ligand 2	Rattus norvegicus	155-160
21963947-6	2011	While the activation of beta adrenergic receptors and the subsequent elevation of cAMP levels seem to be the main pathway for noradrenaline to induce CCL2/MCP-1 in astrocytes, our data indicate that the alpha2 adrenergic receptors also regulate CCL2/MCP-1 expression working as inhibitory mediators.	Norepinephrine	126-139	C-C motif chemokine ligand 2	Rattus norvegicus	245-249
21963947-6	2011	While the activation of beta adrenergic receptors and the subsequent elevation of cAMP levels seem to be the main pathway for noradrenaline to induce CCL2/MCP-1 in astrocytes, our data indicate that the alpha2 adrenergic receptors also regulate CCL2/MCP-1 expression working as inhibitory mediators.	Norepinephrine	126-139	C-C motif chemokine ligand 2	Rattus norvegicus	250-255
22101429-3	2011	Acting via the beta(3)-adrenergic receptors, noradrenaline induces lipolysis in white adipocytes, whereas it stimulates the expression of thermogenic genes, such as PPAR-gamma coactivator 1a (Ppargc1a), uncoupling protein 1 (Ucp1) and acyl-CoA synthetase long-chain family member 1 (Acsl1), in brown adipocytes.	Norepinephrine	45-58	uncoupling protein 1	Homo sapiens	203-223
22101429-3	2011	Acting via the beta(3)-adrenergic receptors, noradrenaline induces lipolysis in white adipocytes, whereas it stimulates the expression of thermogenic genes, such as PPAR-gamma coactivator 1a (Ppargc1a), uncoupling protein 1 (Ucp1) and acyl-CoA synthetase long-chain family member 1 (Acsl1), in brown adipocytes.	Norepinephrine	45-58	uncoupling protein 1	Homo sapiens	225-229
21536121-8	2011	The noradrenaline-induced enhancement of IL-33 production was completely blocked by beta(2)-adrenoceptor specific antagonist ICI 118,551, while beta(2)-adrenoceptor specific agonist salmeterol enhanced DC production of IL-33.	Norepinephrine	4-17	adrenergic receptor, beta 2	Mus musculus	84-104
21996211-1	2011	BACKGROUND: Renalase is an enzyme that catabolizes catecholamines such as adrenaline and noradrenaline in the circulation.	Norepinephrine	89-102	renalase, FAD dependent amine oxidase	Homo sapiens	12-20
21784415-2	2011	In the brain, ALDH1A1 participates in the metabolism of catecholamines including dopamine (DA) and norepinephrine, but is uniquely expressed in a subset of dopaminergic (DAergic) neurons in the ventral mesencephalon where it converts 3,4-dihydroxyphenylacetaldehyde, a potentially toxic aldehyde, to 3,4-dihydroxyphenylacetic acid, a non toxic metabolite.	Norepinephrine	99-113	aldehyde dehydrogenase 1 family member A1	Homo sapiens	14-21
21521766-5	2011	Presynaptic injection of NT or AID peptide into SCGN synapses inhibited synaptic transmission and also attenuated noradrenaline-induced G protein modulation.	Norepinephrine	114-127	secretagogin, EF-hand calcium binding protein	Homo sapiens	48-52
21377513-0	2011	Norepinephrine and ss1-adrenergic signaling facilitate activation of hippocampal CA1 pyramidal neurons during contextual memory retrieval.	Norepinephrine	0-14	carbonic anhydrase 1	Mus musculus	81-84
21347840-7	2011	On the other hand, agents that mobilize Ca(2+) from endoplasmic reticulum such as noradrenaline or thapsigargin, induced Bax translocation, while mitochondrial Ca(2+) release evoked by carbonyl cyanide-p-(trifluoromethoxyphenyl) hydrazone was not able to cause Bax punctation.	Norepinephrine	82-95	BCL2 associated X, apoptosis regulator	Rattus norvegicus	121-124
21347840-7	2011	On the other hand, agents that mobilize Ca(2+) from endoplasmic reticulum such as noradrenaline or thapsigargin, induced Bax translocation, while mitochondrial Ca(2+) release evoked by carbonyl cyanide-p-(trifluoromethoxyphenyl) hydrazone was not able to cause Bax punctation.	Norepinephrine	82-95	BCL2 associated X, apoptosis regulator	Rattus norvegicus	261-264
21302344-2	2011	Well-characterized common functional polymorphisms in the genes MAOA, COMT, and 5HTTLPR each have predictable effects on the availability of the monoamine neurotransmitters dopamine, noradrenaline, and serotonin.	Norepinephrine	183-196	monoamine oxidase A	Homo sapiens	64-68
21297130-4	2011	In C57BL/6 mice immunized with myelin oligodendrocyte glycoprotein peptide 35-55 to develop chronic disease, cortical and spinal cord levels of noradrenaline were significantly reduced versus control mice.	Norepinephrine	144-157	myelin oligodendrocyte glycoprotein	Mus musculus	31-66
16027803-3	2005	Experiments with combined application of acetylcholine and norepinephrine against the background of ouabain showed that the nonspecific action of the test neurotransmitters is related to modulation of Na/K-ATPase activity.	Norepinephrine	59-73	ATPase Na+/K+ transporting subunit alpha 1	Gallus gallus	201-212
15466664-8	2004	In vitro alpha(1)AR mesenteric microvascular contractile responses to endogenous norepinephrine (NE; elicited by electrical field stimulation 10 Hz) was markedly depressed in alpha(1B)AR KO mice compared with WT (12.4+/-1.7% versus 21.5+/-1.2%; P&lt;0.001).	Norepinephrine	81-95	calcium channel, voltage-dependent, N type, alpha 1B subunit	Mus musculus	175-183
15210450-1	2004	There is evidence that neuropeptide Y (NPY) acts as a neurotransmitter in vascular smooth muscle and is released with norepinephrine from sympathetic nerves.	Norepinephrine	118-132	neuropeptide Y	Canis lupus familiaris	23-37
21288809-3	2011	We demonstrate that haploinsufficiency for the O(2)-regulated HIF-2alpha subunit results in augmented carotid body sensitivity to hypoxia, irregular breathing, apneas, hypertension, and elevated plasma norepinephrine levels in adult Hif-2alpha(+/-) mice.	Norepinephrine	202-216	endothelial PAS domain protein 1	Mus musculus	62-72
15210450-1	2004	There is evidence that neuropeptide Y (NPY) acts as a neurotransmitter in vascular smooth muscle and is released with norepinephrine from sympathetic nerves.	Norepinephrine	118-132	neuropeptide Y	Canis lupus familiaris	39-42
14751847-2	2004	Subcutaneous administration of adrenomedullin (1.5 microg.kg(-1).h(-1)) for 1 wk inhibited the ANG II-induced (33.3 microg.kg(-1).h(-1) sc) increase in mean arterial pressure by 67% (P &lt; 0.001) but had no effect of norepinephrine-induced (300 microg.kg(-1).h(-1) sc) hypertension.	Norepinephrine	218-232	adrenomedullin	Rattus norvegicus	31-45
14751847-3	2004	Adrenomedullin enhanced the ANG II-induced improvement in systolic function, resulting in a further 9% increase (P &lt; 0.01) in the left ventricular ejection fraction and 19% increase (P &lt; 0.05) in the left ventricular fractional shortening measured by echocardiography, meanwhile norepinephrine-induced changes in systolic function were remained unaffected.	Norepinephrine	285-299	adrenomedullin	Rattus norvegicus	0-14
15145188-0	2004	Increased norepinephrine production associated with burn injuries results in CCL2 production and type 2 T cell generation.	Norepinephrine	10-24	chemokine (C-C motif) ligand 2	Mus musculus	77-81
21310276-4	2011	The characterization of this disorder provides evidence for the link between DHFR and metabolism of cerebral tetrahydrobiopterin, which is required for the formation of dopamine, serotonin, and norepinephrine and for the hydroxylation of aromatic amino acids.	Norepinephrine	194-208	dihydrofolate reductase	Homo sapiens	77-81
15145188-3	2004	In this study, influence of norepinephrine (NE) on CCL2 production in mice early after thermal injury (TI) was investigated.	Norepinephrine	28-42	chemokine (C-C motif) ligand 2	Mus musculus	51-55
15145612-1	2004	Endogenous catecholamine, epinephrine and norepinephrine, and isoproterenol concentration-dependently induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, and inhibited that of IL-10 in human peripheral blood mononuclear cells (PBMC).	Norepinephrine	42-56	interleukin 18	Homo sapiens	128-147
15145612-1	2004	Endogenous catecholamine, epinephrine and norepinephrine, and isoproterenol concentration-dependently induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, and inhibited that of IL-10 in human peripheral blood mononuclear cells (PBMC).	Norepinephrine	42-56	interleukin 10	Homo sapiens	233-238
15475682-11	2004	Since many of the alpha2A-AR+/non-cholinergic neurons we detected are likely to be GABAergic cells, our data support the hypothesis that noradrenaline may act via basal forebrain cholinergic and non-cholinergic neurons to influence cortical activity.	Norepinephrine	137-150	adrenoceptor alpha 2A	Homo sapiens	18-28
15164608-1	2004	Following exocytotic release of the biogenic amine neurotransmitters, norepinephrine and dopamine, are removed from the synaptic cleft by the respective transporter, norepinephrine transporter (NET) and dopamine transporter (DAT) located on the plasma membrane.	Norepinephrine	70-84	solute carrier family 6 member 3	Homo sapiens	203-223
15164608-1	2004	Following exocytotic release of the biogenic amine neurotransmitters, norepinephrine and dopamine, are removed from the synaptic cleft by the respective transporter, norepinephrine transporter (NET) and dopamine transporter (DAT) located on the plasma membrane.	Norepinephrine	70-84	solute carrier family 6 member 3	Homo sapiens	225-228
14981238-2	2004	To validate this structure, we use the HierDock first principles method to predict the ligand-binding sites for epinephrine and norepinephrine and for eight other ligands, including agonists and antagonists to beta 2 AR and ligands not observed to bind to beta 2 AR.	Norepinephrine	128-142	adrenoceptor beta 2	Homo sapiens	256-265
14656380-7	2003	Agonist competition assays with [3H]DHA showed the following rank order of potency: isoproterenol&gt;epinephrine&gt; norepinephrine, consistent with beta2AR interaction.	Norepinephrine	117-131	adrenoceptor beta 2	Homo sapiens	149-156
12959998-3	2003	Therefore, the effect of testosterone, 17 beta-estradiol, progesterone, and norepinephrine (NE) on adrenergic receptor (AR) gene expression (alpha 2A-, beta 1-, -, and beta 3-AR) and lipolytic activity was investigated in differentiated brown adipocytes in culture.	Norepinephrine	76-90	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	141-177
12807698-0	2003	Norepinephrine transport by the extraneuronal monoamine transporter in human bronchial arterial smooth muscle cells.	Norepinephrine	0-14	solute carrier family 22 member 3	Homo sapiens	32-67
20814407-1	2011	BACKGROUND: Dopamine beta-hydroxylase (DBH) plays an indispensable role in catecholamine synthesis by converting dopamine into norepinephrine.	Norepinephrine	127-141	dopamine beta-hydroxylase	Homo sapiens	12-37
20814407-1	2011	BACKGROUND: Dopamine beta-hydroxylase (DBH) plays an indispensable role in catecholamine synthesis by converting dopamine into norepinephrine.	Norepinephrine	127-141	dopamine beta-hydroxylase	Homo sapiens	39-42
20890184-9	2011	MEASUREMENTS AND MAIN RESULTS: Compared with single norepinephrine therapy, the selective V1aR agonist Phe2-Orn8-Vasotocin reduced norepinephrine requirements (2-6 hrs: p &lt; .05 each) and fluid accumulation (p = .043).	Norepinephrine	131-145	vasopressin V1a receptor	Ovis aries	90-94
20890184-14	2011	In addition, the selective V1aR agonist Phe2-Orn8-Vasotocin slightly prolonged survival when compared with arginine vasopressin (p = .01) and standard treatment with norepinephrine (p = .003).	Norepinephrine	166-180	vasopressin V1a receptor	Ovis aries	27-31
21625389-6	2011	Our results suggest that norepinephrine activity can be further decreased, giving rise to a strong own song selective signal in dorsal NCM.	Norepinephrine	25-39	CWC22 spliceosome associated protein homolog	Homo sapiens	135-138
20926777-0	2010	Identification and functional implication of a Rho kinase-dependent moesin-EBP50 interaction in noradrenaline-stimulated artery.	Norepinephrine	96-109	SLC9A3 regulator 1	Rattus norvegicus	75-80
20926777-5	2010	Immunoprecipitation of EBP50 in noradrenaline-stimulated arteries allowed identification of its interaction with moesin and several other proteins involved in cytoskeleton regulation.	Norepinephrine	32-45	SLC9A3 regulator 1	Rattus norvegicus	23-28
20739611-6	2010	We used conotoxin probes together with subunit-null mice to interrogate nAChR subtypes that modulate hippocampal norepinephrine release.	Norepinephrine	113-127	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	72-77
20858707-4	2010	hPMAT is highly selective toward serotonin (5-HT) and dopamine, with the rank order of transport efficiency (V(max)/K(m)) being: dopamine, 5-HT &gt;&gt; histamine, norepinephrine, epinephrine.	Norepinephrine	164-178	solute carrier family 29 member 4	Homo sapiens	0-5
20435076-4	2010	They contain noradrenaline, but subsets of these neurons also express prolactin-releasing peptide acting synergistically with noradrenaline in the activation of the hypothalamic paraventricular nucleus during stress.	Norepinephrine	126-139	prolactin releasing hormone	Rattus norvegicus	70-97
14512028-9	2003	Our data suggest that HAND2 regulates cell type-specific expression of norepinephrine in concert with Phox2a by a novel mechanism.	Norepinephrine	71-85	heart and neural crest derivatives expressed 2	Homo sapiens	22-27
12904082-3	2003	Derivatives 6 and 7 were able to relax the prostatic portion of rat vas deferens contracted by (-)-noradrenaline because of both their alpha(1A)-antagonist and their NO-donor properties.	Norepinephrine	95-112	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	135-143
20650329-7	2010	We found that DSP-4 treatment depleted the expression of the norepinephrine marker dopamine -hydroxylase (DBH) in the locus coeruleus and its projection area, the basolateral nucleus of the amygdala, confirming locus coeruleus noradrenergic lesion in the experimental animals.	Norepinephrine	61-75	dopamine beta-hydroxylase	Rattus norvegicus	106-109
12871047-9	2003	Physiological substrates for EMT include the monoamines serotonin, dopamine, noradrenaline, adrenaline and histamine.	Norepinephrine	77-90	solute carrier family 22 member 3	Homo sapiens	29-32
20642018-2	2004	MAO-A preferentially oxidizes serotonin and noradrenaline, whereas MAO-B preferentially oxidizes phenethylamine.	Norepinephrine	44-57	monoamine oxidase A	Homo sapiens	0-5
20448147-1	2010	A neurotransmitter, norepinephrine (NE), amplifies the mitogenic effect of epidermal growth factor (EGF) in the liver by acting on the alpha(1)-adrenergic receptor coupled with G protein, Galpha(h).	Norepinephrine	20-34	epidermal growth factor	Homo sapiens	75-98
12761825-5	2003	LYAAT-1-IR (immunoreactivity) levels varied among different neuroanatomical structures but were present in neurons independently of the neurotransmitter used (glutamate, GABA, acetylcholine, noradrenaline, serotonin, or glycine).	Norepinephrine	191-204	solute carrier family 36 member 1	Rattus norvegicus	0-7
20448147-1	2010	A neurotransmitter, norepinephrine (NE), amplifies the mitogenic effect of epidermal growth factor (EGF) in the liver by acting on the alpha(1)-adrenergic receptor coupled with G protein, Galpha(h).	Norepinephrine	20-34	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	188-194
20402963-6	2010	However, OCT3 was determined to be a high-capacity and low-affinity transporter for the neurotransmitters dopamine (DA), norepinephrine (NE), and serotonin (5-HT).	Norepinephrine	121-135	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	9-13
12620813-4	2003	2-APB and heparin abolished norepinephrine (10 microM; 0 Ca2+)-evoked Ca2+ transients but increased caffeine (10 mM; 0 Ca2+) transients in fura 2-loaded myocytes.	Norepinephrine	28-42	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	57-60
20388489-6	2010	Unlike the other members of the mitochondrial carrier superfamily, the eutherian uncoupling protein UCP1 has evolved to achieve its heat-generating capacity in the physiological context provided by the brown adipocyte and therefore it is activated by the low fatty acid concentrations generated by the noradrenaline-stimulated lipolysis.	Norepinephrine	302-315	uncoupling protein 1	Homo sapiens	100-104
12620813-4	2003	2-APB and heparin abolished norepinephrine (10 microM; 0 Ca2+)-evoked Ca2+ transients but increased caffeine (10 mM; 0 Ca2+) transients in fura 2-loaded myocytes.	Norepinephrine	28-42	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	70-73
12620813-4	2003	2-APB and heparin abolished norepinephrine (10 microM; 0 Ca2+)-evoked Ca2+ transients but increased caffeine (10 mM; 0 Ca2+) transients in fura 2-loaded myocytes.	Norepinephrine	28-42	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	70-73
12620813-6	2003	Ca2+ sparks and transients evoked by norepinephrine and caffeine were abolished by thimerosal (100 microM), which sensitizes the IP3R to IP3.	Norepinephrine	37-51	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	0-3
12889599-4	2003	Our results show that met-enkephalin, substance P, bombesin, dopamine, and norepinephrine have a stimulatory effect on the migration of the breast cancer cells; moreover, these cells show positive chemotaxis towards norepinephrine as was analyzed by the directionality and persistence on a single-cell basis.	Norepinephrine	216-230	gastrin releasing peptide	Homo sapiens	51-59
12802495-11	2003	Obesity and a polymorphism in the perilipin gene associate with decreased protein content of perilipin and increased basal (unstrained) and noradrenaline-induced lipolysis.	Norepinephrine	140-153	perilipin 1	Homo sapiens	34-43
12618215-1	2003	Noradrenaline-stimulated phosphoinositide breakdown in cultured glia was found to be mediated by alpha(1A)-adrenoceptors.	Norepinephrine	0-13	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	97-105
12618215-2	2003	The alpha(1A)-selective agonist A61603 was as effective as noradrenaline in eliciting 3H-inositol phosphate (IP) accumulation but was approximately 50-fold more potent.	Norepinephrine	59-72	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	4-12
12618215-3	2003	In addition, the use of selective antagonists revealed a clear rank order of potency in the ability of these drugs to reverse the effect of noradrenaline on phosphoinositide breakdown: RS17053 (alpha(1A)-selective) &gt;&gt;AH11110A (alpha(1B)-selective)&gt;BMY7378 (alpha(1D)-selective).	Norepinephrine	140-153	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	194-202
12651937-5	2003	The norepinephrine effect was blocked by the selective beta(2)-adrenoceptor antagonist, ICI 118,551, but not by pre-treatment with the selective beta(1)-adrenoceptor antagonist, atenolol.	Norepinephrine	4-18	adrenoceptor beta 2	Bos taurus	55-75
20332182-1	2010	Monoamine oxidase A (MAOA) and the transporters for serotonin (5-HTT) and norepinephrine (NET) may play important roles in regulating maternal monoamine neurotransmitters transferred across the placenta to the fetus.	Norepinephrine	74-88	monoamine oxidase A	Homo sapiens	0-19
20332182-1	2010	Monoamine oxidase A (MAOA) and the transporters for serotonin (5-HTT) and norepinephrine (NET) may play important roles in regulating maternal monoamine neurotransmitters transferred across the placenta to the fetus.	Norepinephrine	74-88	monoamine oxidase A	Homo sapiens	21-25
20193660-0	2010	Pontine norepinephrine defects in Mecp2-null mice involve deficient expression of dopamine beta-hydroxylase but not a loss of catecholaminergic neurons.	Norepinephrine	8-22	methyl CpG binding protein 2	Mus musculus	34-39
20042730-12	2010	These results indicate that there are several electrophysiological abnormalities in LC neurons of Mecp2(-/Y) mice, which may contribute to the dysfunction of the norepinephrine system in Rett syndrome.	Norepinephrine	162-176	methyl CpG binding protein 2	Mus musculus	98-103
20035031-6	2010	Isoproterenol-induced coronary vasodilation was mediated through the beta(2)-adrenoceptor, whereas norepinephrine-induced coronary vasodilation was principally mediated through the beta(1)-adrenoceptor.	Norepinephrine	99-113	adrenoceptor beta 1	Sus scrofa	181-201
20009769-1	2010	RATIONALE: Dopamine beta-hydroxylase (DBH) plays an essential role in catecholamine synthesis by converting dopamine into norepinephrine.	Norepinephrine	122-136	dopamine beta-hydroxylase	Homo sapiens	11-36
20009769-1	2010	RATIONALE: Dopamine beta-hydroxylase (DBH) plays an essential role in catecholamine synthesis by converting dopamine into norepinephrine.	Norepinephrine	122-136	dopamine beta-hydroxylase	Homo sapiens	38-41
19860854-3	2010	The initiation of Aanat transcription at night is controlled largely by the norepinephrine-stimulated phosphorylation of cAMP response element-binding protein by protein kinase A.	Norepinephrine	76-90	aralkylamine N-acetyltransferase	Rattus norvegicus	18-23
19912474-1	2010	The prolactin-releasing peptide (PrRP) has been proposed to be a co-transmitter or modulator of noradrenaline (NA) because it colocalises with NA in the A1 (in the ventrolateral reticular formation) and A2 (in the nucleus of the solitary tract; NTS) cell groups in the caudal medulla.	Norepinephrine	96-109	prolactin releasing hormone	Rattus norvegicus	4-31
12690430-13	2003	In additional experiments, designed to study the native murine beta(1)-adrenoceptor function, we used the physiological beta(1)-adrenoceptor agonist (-)-noradrenaline.	Norepinephrine	149-166	adrenergic receptor, beta 1	Mus musculus	120-140
12618232-9	2003	CONCLUSION: These findings suggest that norepinephrine-induced hypertrophy is linked closely with p38 MAP kinase activation, which can be endogenously modulated through estrogen-responsive regulation of MKP-1 expression.	Norepinephrine	40-54	dual specificity phosphatase 1	Mus musculus	203-208
12603820-2	2003	nAChR activation regulates release of various neurotransmitters, including norepinephrine (NA).	Norepinephrine	75-89	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	0-5
19912474-1	2010	The prolactin-releasing peptide (PrRP) has been proposed to be a co-transmitter or modulator of noradrenaline (NA) because it colocalises with NA in the A1 (in the ventrolateral reticular formation) and A2 (in the nucleus of the solitary tract; NTS) cell groups in the caudal medulla.	Norepinephrine	96-109	prolactin releasing hormone	Rattus norvegicus	33-37
19482560-1	2009	In this study we investigated the changes in norepinephrine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) gene expression in the stellate ganglia of naive controls and long-term socially isolated (12 weeks) adult rats and the response of these animals to additional immobilization stress.	Norepinephrine	45-59	dopamine beta-hydroxylase	Rattus norvegicus	108-133
19482560-1	2009	In this study we investigated the changes in norepinephrine biosynthetic enzymes tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT) gene expression in the stellate ganglia of naive controls and long-term socially isolated (12 weeks) adult rats and the response of these animals to additional immobilization stress.	Norepinephrine	45-59	dopamine beta-hydroxylase	Rattus norvegicus	135-138
19388884-10	2009	We also measured extracellular glutamate and norepinephrine concentration in hippocampal CA1 in the four groups.	Norepinephrine	45-59	carbonic anhydrase 1	Rattus norvegicus	89-92
19573018-7	2009	Transfection of shRNAs specific to Phox2a or Phox2b genes significantly reduced mRNA and protein levels of NET and DBH after shutdown of endogenous Phox2, which was accompanied by a decreased [(3)H]norepinephrine uptake.	Norepinephrine	198-212	dopamine beta-hydroxylase	Homo sapiens	115-118
19500370-10	2009	RESULTS: In the animals receiving the Sry1 plasmid there were significant increases after 21 days in resting plasma norepinephrine (NE, 27%) and renal tyrosine hydroxylase content (41%, p &lt; .05) compared to controls.	Norepinephrine	116-130	sex determining region Y	Rattus norvegicus	38-42
19371348-0	2009	Neuropeptide S selectively inhibits the release of 5-HT and noradrenaline from mouse frontal cortex nerve endings.	Norepinephrine	60-73	neuropeptide S	Mus musculus	0-14
19244246-7	2009	Norepinephrine-mediated depression on neuronal excitability was mediated by activation of TREK-2, a type of two-pore domain K(+) channel, and mutation of the protein kinase A phosphorylation site on TREK-2 channels annulled the effects of norepinephrine.	Norepinephrine	0-14	potassium two pore domain channel subfamily K member 10	Homo sapiens	90-96
19244246-7	2009	Norepinephrine-mediated depression on neuronal excitability was mediated by activation of TREK-2, a type of two-pore domain K(+) channel, and mutation of the protein kinase A phosphorylation site on TREK-2 channels annulled the effects of norepinephrine.	Norepinephrine	0-14	potassium two pore domain channel subfamily K member 10	Homo sapiens	199-205
19244246-7	2009	Norepinephrine-mediated depression on neuronal excitability was mediated by activation of TREK-2, a type of two-pore domain K(+) channel, and mutation of the protein kinase A phosphorylation site on TREK-2 channels annulled the effects of norepinephrine.	Norepinephrine	239-253	potassium two pore domain channel subfamily K member 10	Homo sapiens	90-96
19244246-7	2009	Norepinephrine-mediated depression on neuronal excitability was mediated by activation of TREK-2, a type of two-pore domain K(+) channel, and mutation of the protein kinase A phosphorylation site on TREK-2 channels annulled the effects of norepinephrine.	Norepinephrine	239-253	potassium two pore domain channel subfamily K member 10	Homo sapiens	199-205
19244246-8	2009	Our results indicate a novel action mode in which norepinephrine depresses neuronal excitability in the entorhinal cortex by disinhibiting protein kinase A-mediated tonic inhibition of TREK-2 channels.	Norepinephrine	50-64	potassium two pore domain channel subfamily K member 10	Homo sapiens	185-191
18849110-0	2009	The inhibitory effect of norepinephrine on the migration of ES-2 ovarian carcinoma cells involves a Rap1-dependent pathway.	Norepinephrine	25-39	RAP1A, member of RAS oncogene family	Homo sapiens	100-104
12591155-7	2003	Furthermore, evidence was obtained that (i) adrenaline and noradrenaline share the same binding site, and that this site would correspond to a repeated sequence present in the SCO-spondin, the major protein component of RF; and (ii) serotonin has its own binding site in RF.	Norepinephrine	59-72	SCO-spondin	Bos taurus	176-187
12538832-0	2003	Norepinephrine-induced stimulation of p38 mitogen-activated protein kinase is mediated by arachidonic acid metabolites generated by activation of cytosolic phospholipase A(2) in vascular smooth muscle cells.	Norepinephrine	0-14	cytosolic phospholipase A2	Oryctolagus cuniculus	146-173
12488332-0	2003	Immunolesion of norepinephrine and epinephrine afferents to medial hypothalamus alters basal and 2-deoxy-D-glucose-induced neuropeptide Y and agouti gene-related protein messenger ribonucleic acid expression in the arcuate nucleus.	Norepinephrine	16-30	agouti related neuropeptide	Homo sapiens	142-169
12215478-7	2002	Preganglionic electrical stimulation (0.5 Hz) raised basal norepinephrine levels 11-fold and further enhanced the angiotensin-induced increase in norepinephrine (4.04 ng/mL at 1 microg/kg ANG).	Norepinephrine	146-160	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	Mus musculus	170-177
19236326-4	2009	Also, we found that NO released from hypothalamic NOergic neurons in response to norepinephrine diffuses to luteinizing hormone-releasing hormone (LHRH) neurons that activate cyclooxygenase and guanylate cyclase.	Norepinephrine	81-95	gonadotropin releasing hormone 1	Rattus norvegicus	108-145
19236326-4	2009	Also, we found that NO released from hypothalamic NOergic neurons in response to norepinephrine diffuses to luteinizing hormone-releasing hormone (LHRH) neurons that activate cyclooxygenase and guanylate cyclase.	Norepinephrine	81-95	gonadotropin releasing hormone 1	Rattus norvegicus	147-151
19038969-6	2009	Combined activation of insulin-like growth factor 1 and epidermal growth factor receptors was particularly notable for antagonistic interactions at some levels of signal transduction and norepinephrine production, but potentiation at other levels of signaling and cytoprotection.	Norepinephrine	187-201	epidermal growth factor	Homo sapiens	56-79
19129402-0	2009	Astrocyte-derived MCP-1 mediates neuroprotective effects of noradrenaline.	Norepinephrine	60-73	C-C motif chemokine ligand 2	Homo sapiens	18-23
21274292-0	2009	The relationship between leptin and norepinephrine levels during OGTT in normotensive and hypertensive obese adolescents.	Norepinephrine	36-50	leptin	Homo sapiens	25-31
21274292-3	2009	Our study is designed to explore the relationship between leptin and norepinephrine levels in pediatric patients and to identify any contributors to hypertension for this population.	Norepinephrine	69-83	leptin	Homo sapiens	58-64
18781376-2	2009	Here, we investigated the mechanism of hERG K(+) channel current (I(hERG)) blockade expressed in HEK-293 cells by sibutramine HCl, a serotonin-norepinephrine reuptake inhibitor.	Norepinephrine	143-157	potassium voltage-gated channel subfamily H member 2	Homo sapiens	39-73
18973765-2	2009	The balance of dopamine and noradrenaline in the cortex is controlled by the DBH gene.	Norepinephrine	28-41	dopamine beta-hydroxylase	Homo sapiens	77-80
19212441-3	2009	Phagocytes isolated from adrenalectomized rats displayed enhanced expression of tyrosine-hydroxylase and dopamine-beta-hydroxylase, two key enzymes for catecholamine production and exhibited higher baseline secretion of norepinephrine and epinephrine.	Norepinephrine	220-234	dopamine beta-hydroxylase	Rattus norvegicus	105-130
19020050-5	2008	Conversely, the transfection of synthetic anti-miR oligonucleotides that inhibit miR-338 increases COXIV levels, and results in a significant increase in oxidative phosphorylation and also norepinephrine uptake in the axons.	Norepinephrine	189-203	microRNA 338	Homo sapiens	81-88
18722504-1	2008	Local application of alphabetaMeATP (ligand for P2X3 receptors) and capsaicin (ligand for TRPV1 receptors) to the rat hindpaw produces pain behaviors (flinching) which are enhanced by noradrenaline (NA).	Norepinephrine	184-197	purinergic receptor P2X 3	Rattus norvegicus	48-52
18437281-1	2008	Monoamine oxidase A (MAOA) abnormality has been suggested as a crucial factor in the pathogenesis of mood disorder, because MAOA is associated with the metabolism of monoamines such as serotonin and norepinephrine.	Norepinephrine	199-213	monoamine oxidase A	Homo sapiens	0-19
18437281-1	2008	Monoamine oxidase A (MAOA) abnormality has been suggested as a crucial factor in the pathogenesis of mood disorder, because MAOA is associated with the metabolism of monoamines such as serotonin and norepinephrine.	Norepinephrine	199-213	monoamine oxidase A	Homo sapiens	21-25
18437281-1	2008	Monoamine oxidase A (MAOA) abnormality has been suggested as a crucial factor in the pathogenesis of mood disorder, because MAOA is associated with the metabolism of monoamines such as serotonin and norepinephrine.	Norepinephrine	199-213	monoamine oxidase A	Homo sapiens	124-128
18772255-0	2008	Intra-amygdala injections of CREB antisense impair inhibitory avoidance memory: role of norepinephrine and acetylcholine.	Norepinephrine	88-102	cAMP responsive element binding protein 1	Rattus norvegicus	29-33
18772255-7	2008	In addition, CREB antisense infusions dampened the training-related release of norepinephrine, and to a lesser extent of acetylcholine, in the amygdala.	Norepinephrine	79-93	cAMP responsive element binding protein 1	Rattus norvegicus	13-17
18772255-9	2008	These findings suggest that intra-amygdala treatment with CREB antisense may affect processes involved in modulation of memory in part through interference with norepinephrine and acetylcholine neurotransmission in the amygdala.	Norepinephrine	161-175	cAMP responsive element binding protein 1	Rattus norvegicus	58-62
12186683-9	2002	Stress decreased dopaminergic activity in the frontal cortex and amygdala of males but not females; whereas, in CA3 of the hippocampus, stress increased levels of 5-HT and norepinephrine in females, but not males, and increased GABA in males, but not females.	Norepinephrine	172-186	carbonic anhydrase 3	Rattus norvegicus	112-115
12124378-3	2002	This tyrosine residue is conserved within the third transmembrane domain in members of the Na(+):neurotransmitter transporter family (SNF), where it plays a role in binding pharmacological ligands such as cocaine to the serotonin (SERT), dopamine (DAT) and norepinephrine (NET) transporters.	Norepinephrine	257-271	small nuclear ribonucleoprotein polypeptide A S homeolog	Xenopus laevis	134-137
12124378-3	2002	This tyrosine residue is conserved within the third transmembrane domain in members of the Na(+):neurotransmitter transporter family (SNF), where it plays a role in binding pharmacological ligands such as cocaine to the serotonin (SERT), dopamine (DAT) and norepinephrine (NET) transporters.	Norepinephrine	257-271	solute carrier family 6 (neurotransmitter transporter), member 3 S homeolog	Xenopus laevis	248-251
12090750-9	2002	A significant correlation between protein and neurohumoral levels was exclusively found for the Na+-Ca2+ exchanger with norepinephrine (r=0.64; P=0.01).	Norepinephrine	120-134	nascent polypeptide associated complex subunit alpha 2	Homo sapiens	96-103
12170059-10	2002	CONCLUSION: These results suggest that one mechanism by which nAChR agonists act for analgesia is to stimulate spinal norepinephrine release.	Norepinephrine	118-132	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	62-67
12065661-2	2002	5-HT is present in organelles distinct from l-glutamate-containing synaptic-like microvesicles as well as in the cytoplasm of pinealocytes, and is secreted upon stimulation by norepinephrine (NE) to enhance serotonin N-acetyltransferase activity via the 5-HT2 receptor.	Norepinephrine	176-190	aralkylamine N-acetyltransferase	Homo sapiens	207-236
11922898-11	2002	In parallel, norepinephrine caused a translocation of PKC-alpha and PKC-delta into the particular fractions and this effect of norepinephrine was also enhanced by co-presence of NPY.	Norepinephrine	13-27	protein kinase C, alpha	Rattus norvegicus	54-63
11922898-11	2002	In parallel, norepinephrine caused a translocation of PKC-alpha and PKC-delta into the particular fractions and this effect of norepinephrine was also enhanced by co-presence of NPY.	Norepinephrine	127-141	protein kinase C, alpha	Rattus norvegicus	54-63
12196911-1	2002	The norepinephrine, dopamine and serotonin transporters (NET, DAT and SERT, respectively), limit cellular signaling by recapturing released neurotransmitter, and serve as targets for antidepressants and drugs of abuse, emphasizing the integral role these molecules play in neurotransmission and pathology.	Norepinephrine	4-18	solute carrier family 6 member 3	Homo sapiens	62-65
11429392-4	2001	5-Methyl-urapidil competitively antagonized responses to noradrenaline with a pK(B) value of 8.48 and a Schild slope of 0.99, consistent with the presence of alpha(1A)-adrenoceptors.	Norepinephrine	57-70	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	158-166
11408527-7	2001	Norepinephrine is known to activate alpha1-adrenoceptors and PKC.	Norepinephrine	0-14	protein kinase C, gamma	Rattus norvegicus	61-64
18239728-6	2001	The beta agonist isoproterenol mimicked the effect of norepinephrine on oscillation frequency and truncated the responses suggesting that a beta-adrenergic upregulation of H current modifies the internal structure (frequency) of thalamic oscillations.	Norepinephrine	54-68	amyloid beta precursor protein	Rattus norvegicus	138-144
11440275-7	2001	Adrenomedullin levels correlated with plasma noradrenaline (r = 0.516, p = 0.0124).	Norepinephrine	45-58	adrenomedullin	Homo sapiens	0-14
11440275-11	2001	CONCLUSIONS: This study demonstrates that circulating adrenomedullin is increased in pheochromocytoma, and is also correlated with plasma noradrenaline levels.	Norepinephrine	138-151	adrenomedullin	Homo sapiens	54-68
11306173-5	2001	When HB2 cells were stimulated by norepinephrine, the VEGF mRNA level increased without a change in that of VEGF-B, while the VEGF-C mRNA level decreased.	Norepinephrine	34-48	vascular endothelial growth factor A	Mus musculus	54-58
11092898-1	2001	The norepinephrine (NET) and dopamine (DAT) transporters are highly homologous proteins, displaying many pharmacological similarities.	Norepinephrine	4-18	solute carrier family 6 member 3	Homo sapiens	39-42
18227761-1	2008	BACKGROUND: The monoamine oxidase-A (MAOA) gene plays a vital role in the metabolism of neurotransmitters, e.g, serotonin, norepinephrine, and dopamine.	Norepinephrine	123-137	monoamine oxidase A	Homo sapiens	16-35
18227761-1	2008	BACKGROUND: The monoamine oxidase-A (MAOA) gene plays a vital role in the metabolism of neurotransmitters, e.g, serotonin, norepinephrine, and dopamine.	Norepinephrine	123-137	monoamine oxidase A	Homo sapiens	37-41
18312831-1	2008	INTRODUCTION: The norepinephrine transporter (NET) is located presynaptically on noradrenergic nerve terminals and plays a critical role in the regulation of the synaptic norepinephrine (NE) concentration via the reuptake of NE.	Norepinephrine	18-32	solute carrier family 6 member 2	Rattus norvegicus	46-49
18673168-2	2008	As such, modulation of the histamine H(3) receptor is expected to affect wake via control of the release of histamine and to affect cognition via regulation of several other neurotransmitters including acetylcholine and norepinephrine.	Norepinephrine	220-234	histamine receptor H3	Homo sapiens	27-50
19020660-11	2008	CONCLUSIONS: Our results show that the binding of apoB100-LDL to adipocytes via the LDL receptor inhibits intracellular noradrenaline-induced lipolysis in adipocytes.	Norepinephrine	120-133	apolipoprotein B	Mus musculus	50-57
18054863-6	2007	These data illustrate a mechanism of presynaptic modulation where the output of a large multiple-release-site synapse is potently regulated by endogenously released noradrenaline and suggests that the CeA may be a target for the central nociceptive actions of noradrenaline.	Norepinephrine	165-178	pregnancy specific beta-1-glycoprotein 2	Homo sapiens	201-204
18054863-6	2007	These data illustrate a mechanism of presynaptic modulation where the output of a large multiple-release-site synapse is potently regulated by endogenously released noradrenaline and suggests that the CeA may be a target for the central nociceptive actions of noradrenaline.	Norepinephrine	260-273	pregnancy specific beta-1-glycoprotein 2	Homo sapiens	201-204
18396760-0	2007	[The influence of terbutaline on VEGF gene expression in rat astrocytes after norepinephrine and burn serum induction].	Norepinephrine	78-92	vascular endothelial growth factor A	Rattus norvegicus	33-37
18396760-1	2007	OBJECTIVE: To investigate the influence of adrenoreceptor beta-agonists terbutaline on gene expression of vascular endothelial growth factor (VEGF) in rat astrocyte after induction by norepinephrine (NE) and burn serum.	Norepinephrine	184-198	vascular endothelial growth factor A	Rattus norvegicus	106-140
18396760-1	2007	OBJECTIVE: To investigate the influence of adrenoreceptor beta-agonists terbutaline on gene expression of vascular endothelial growth factor (VEGF) in rat astrocyte after induction by norepinephrine (NE) and burn serum.	Norepinephrine	184-198	vascular endothelial growth factor A	Rattus norvegicus	142-146
17673674-1	2007	Alpha2-adrenoceptors are essential presynaptic regulators of norepinephrine release from sympathetic nerves.	Norepinephrine	61-75	adrenergic receptor, alpha 2b	Mus musculus	0-20
17200925-2	2007	The gene encoding dopamine beta-hydroxylase (DBH) could be one such factor since this hydroxylase converts dopamine to norepinephrine both of which are involved in cognition regulation.	Norepinephrine	119-133	dopamine beta-hydroxylase	Homo sapiens	18-43
17200925-2	2007	The gene encoding dopamine beta-hydroxylase (DBH) could be one such factor since this hydroxylase converts dopamine to norepinephrine both of which are involved in cognition regulation.	Norepinephrine	119-133	dopamine beta-hydroxylase	Homo sapiens	45-48
17923045-16	2007	CONCLUSION: Sustained caused increased tone of sympathetic, heterogeneous accumulation of noradrenaline and down regulation of beta1 receptor, which was mediated by NGF.	Norepinephrine	90-103	nerve growth factor	Canis lupus familiaris	165-168
17531968-6	2007	To determine whether Hand2 regulates noradrenergic differentiation, the levels of the norepinephrine biosynthetic enzymes, tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH) was examined.	Norepinephrine	86-100	heart and neural crest derivatives expressed 2	Mus musculus	21-26
11262584-5	2001	In clinical studies carbonic anhydrase I from erythrocytes increased by 87% after noradrenaline administration, by 71% after orciprenaline and by 82% after isoprenaline.	Norepinephrine	82-95	carbonic anhydrase 1	Homo sapiens	20-40
11226400-2	2001	Endothelin-1 (10(-10) M) potentiated the contractions induced by electrical stimulation and noradrenaline.	Norepinephrine	92-105	endothelin-1	Oryctolagus cuniculus	0-12
11226400-6	2001	The results indicate that endothelin-1 potentiates the responses to electrical stimulation and noradrenaline by activating endothelin ET(B) receptors.	Norepinephrine	95-108	endothelin-1	Oryctolagus cuniculus	26-38
11171092-0	2001	As the proliferation promoter noradrenaline induces expression of ICER (induced cAMP early repressor) in proliferative brown adipocytes, ICER may not be a universal tumour suppressor.	Norepinephrine	30-43	cAMP responsive element modulator	Homo sapiens	66-70
11171092-0	2001	As the proliferation promoter noradrenaline induces expression of ICER (induced cAMP early repressor) in proliferative brown adipocytes, ICER may not be a universal tumour suppressor.	Norepinephrine	30-43	cAMP responsive element modulator	Homo sapiens	72-100
11171092-0	2001	As the proliferation promoter noradrenaline induces expression of ICER (induced cAMP early repressor) in proliferative brown adipocytes, ICER may not be a universal tumour suppressor.	Norepinephrine	30-43	cAMP responsive element modulator	Homo sapiens	137-141
11171092-4	2001	In brown adipocytes in primary culture, ICER gene expression was induced by noradrenaline (norepinephrine) not only in the mature state (where noradrenaline potentiates differentiation), but also in the proliferative state of the cell cultures (where noradrenaline enhances cell proliferation).	Norepinephrine	76-89	cAMP responsive element modulator	Homo sapiens	40-44
11171092-4	2001	In brown adipocytes in primary culture, ICER gene expression was induced by noradrenaline (norepinephrine) not only in the mature state (where noradrenaline potentiates differentiation), but also in the proliferative state of the cell cultures (where noradrenaline enhances cell proliferation).	Norepinephrine	91-105	cAMP responsive element modulator	Homo sapiens	40-44
11171092-4	2001	In brown adipocytes in primary culture, ICER gene expression was induced by noradrenaline (norepinephrine) not only in the mature state (where noradrenaline potentiates differentiation), but also in the proliferative state of the cell cultures (where noradrenaline enhances cell proliferation).	Norepinephrine	143-156	cAMP responsive element modulator	Homo sapiens	40-44
11171092-4	2001	In brown adipocytes in primary culture, ICER gene expression was induced by noradrenaline (norepinephrine) not only in the mature state (where noradrenaline potentiates differentiation), but also in the proliferative state of the cell cultures (where noradrenaline enhances cell proliferation).	Norepinephrine	143-156	cAMP responsive element modulator	Homo sapiens	40-44
11258636-3	2001	At the point of exhaustion significantly higher values for norepinephrine and epinephrine were observed in ST2 than in ST1.	Norepinephrine	59-73	ST2	Homo sapiens	107-110
11123297-0	2001	IFN-gamma production by Th1 cells generated from naive CD4+ T cells exposed to norepinephrine.	Norepinephrine	79-93	CD4 antigen	Mus musculus	55-58
11123297-1	2001	During activation in vivo, naive CD4(+) T cells are exposed to various endogenous ligands, such as cytokines and the neurotransmitter norepinephrine (NE).	Norepinephrine	134-148	CD4 antigen	Mus musculus	33-36
11179598-3	2001	Blockade of CRH receptors with alphah-CRF (10 microg) attenuated or blocked the BN-induced rise in plasma ACTH, epinephrine, norepinephrine, glucose and corticosterone levels.	Norepinephrine	125-139	gastrin releasing peptide	Homo sapiens	80-82
11145760-10	2000	Immunoreactive G-protein coupled receptor kinase-2 level was increased in denervated rabbits receiving norepinephrine.	Norepinephrine	103-117	beta-adrenergic receptor kinase 1	Oryctolagus cuniculus	15-50
11032873-5	2000	Both sodium propionate and 5-(N,N-hexamethylene)amiloride (HMA), two treatments that abolished the effect of norepinephrine on cytoplasmic alkalization, also reduced norepinephrine-mediated increases in membrane-associated PKCalpha, delta, and epsilon.	Norepinephrine	109-123	protein kinase C, alpha	Rattus norvegicus	223-231
17448453-1	2007	OBJECTIVE: Phenylethanolamine-N-methyltransferase (PNMT), the enzyme that synthesizes epinephrine (EPI) from norepinephrine (NE) in the adrenal gland, is present in extra-adrenal tissues including heart.	Norepinephrine	109-123	phenylethanolamine N-methyltransferase	Oryctolagus cuniculus	51-55
17448453-1	2007	OBJECTIVE: Phenylethanolamine-N-methyltransferase (PNMT), the enzyme that synthesizes epinephrine (EPI) from norepinephrine (NE) in the adrenal gland, is present in extra-adrenal tissues including heart.	Norepinephrine	109-123	phenylethanolamine N-methyltransferase	Oryctolagus cuniculus	11-49
11032873-5	2000	Both sodium propionate and 5-(N,N-hexamethylene)amiloride (HMA), two treatments that abolished the effect of norepinephrine on cytoplasmic alkalization, also reduced norepinephrine-mediated increases in membrane-associated PKCalpha, delta, and epsilon.	Norepinephrine	166-180	protein kinase C, alpha	Rattus norvegicus	223-231
11012844-4	2000	Intraperitoneal preadministration of a selective nonpeptidic CRFR1 antagonist, CRA1000, completely blocked the conditioned fear-induced release of noradrenaline.	Norepinephrine	147-160	corticotropin releasing hormone receptor 1	Rattus norvegicus	61-66
20144064-1	2007	The histamine H(3) receptor is involved in the central and peripheral regulation of levels of histamine and other neurotransmitters (e.g., acetylcholine, noradrenaline, dopamine, serotonin and GABA), which sets it up as a target in the treatment of various CNS (e.g., depression, schizophrenia, ADHD, dementia, neuropathic pain and sleep disorders), metabolic syndrome (e.g., obesity) and allergic disorders.	Norepinephrine	154-167	histamine receptor H3	Homo sapiens	4-27
11012844-5	2000	These results suggest that CRFR1 is involved in the release of noradrenaline in the hypothalamic PVN induced by conditioned fear.	Norepinephrine	63-76	corticotropin releasing hormone receptor 1	Rattus norvegicus	27-32
10993216-5	2000	These results suggest that serotonin and noradrenaline are likely involved in the modulation of the expression of Fos-ir cells in response to the urine in the accessory olfactory bulb.	Norepinephrine	41-54	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	114-117
17437549-1	2007	We recently reported a diurnal and norepinephrine (NE) -induced expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) in the rat pineal gland and postulated that this MKP-1 expression might impact adrenergic-regulated arylalkylamine-N-acetyltransferase (AA-NAT) activity via modulation of MAPKs.	Norepinephrine	35-49	dual specificity phosphatase 1	Rattus norvegicus	133-138
17437549-1	2007	We recently reported a diurnal and norepinephrine (NE) -induced expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) in the rat pineal gland and postulated that this MKP-1 expression might impact adrenergic-regulated arylalkylamine-N-acetyltransferase (AA-NAT) activity via modulation of MAPKs.	Norepinephrine	35-49	dual specificity phosphatase 1	Rattus norvegicus	189-194
17437549-1	2007	We recently reported a diurnal and norepinephrine (NE) -induced expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) in the rat pineal gland and postulated that this MKP-1 expression might impact adrenergic-regulated arylalkylamine-N-acetyltransferase (AA-NAT) activity via modulation of MAPKs.	Norepinephrine	35-49	aralkylamine N-acetyltransferase	Rattus norvegicus	240-274
17437549-1	2007	We recently reported a diurnal and norepinephrine (NE) -induced expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) in the rat pineal gland and postulated that this MKP-1 expression might impact adrenergic-regulated arylalkylamine-N-acetyltransferase (AA-NAT) activity via modulation of MAPKs.	Norepinephrine	35-49	aralkylamine N-acetyltransferase	Rattus norvegicus	276-282
10910482-7	2000	Similarly, incubation of PBMCs (T1) with plasma obtained after CPB (T2) as well as addition of IL-10 or norepinephrine in concentrations present in plasma after CPB led to a reduced lipopolysaccharide-stimulated TNF-alpha and an increased IL-10 response.	Norepinephrine	104-118	interleukin 10	Homo sapiens	239-244
10910482-11	2000	Although norepinephrine fails to induce a cytokine response in the absence of other stimuli, its administration seems to augment the antiinflammatory IL-10 response while attenuating the TNF-alpha response.	Norepinephrine	9-23	interleukin 10	Homo sapiens	150-155
10860769-0	2000	Isolation and characterization of the murine cardiotrophin-1 gene: expression and norepinephrine-induced transcriptional activation.	Norepinephrine	82-96	cardiotrophin 1	Mus musculus	45-60
17725036-2	2007	An immunocytochemical study has been performed of development of neurons producing gonadotropin-releasing hormone (GnRH) under conditions of excess of serotonin and noradrenaline in the mice in embryogenesis.	Norepinephrine	165-178	gonadotropin releasing hormone 1	Mus musculus	83-113
10860769-3	2000	In this study, we isolated and characterized the mouse CT-1 gene and studied the expression of CT-1 mRNA under norepinephrine (NE) stimulation.	Norepinephrine	111-125	cardiotrophin 1	Mus musculus	95-99
17725036-2	2007	An immunocytochemical study has been performed of development of neurons producing gonadotropin-releasing hormone (GnRH) under conditions of excess of serotonin and noradrenaline in the mice in embryogenesis.	Norepinephrine	165-178	gonadotropin releasing hormone 1	Mus musculus	115-119
17725036-5	2007	The percent of the GnRH-neurons in the Tg8 mouse embryos in caudal parts of the migration trajectory was lower than in rostral parts, the opposite distribution of the neurons being observed in the C3H line mouse embryos; at the excess of serotonin and noradrenaline in the Tg8 line mouse embryos, the total amount of GnRH-neurons in the brain was lower than in the C3H mice.	Norepinephrine	252-265	gonadotropin releasing hormone 1	Mus musculus	19-23
17725036-6	2007	In males of the Tg8 line mice under conditions of excess of serotonin and noradrenaline the optical density of neurons, which correlated with the GnRH concentration in the cell, was higher than in control mice.	Norepinephrine	74-87	gonadotropin releasing hormone 1	Mus musculus	146-150
17725036-7	2007	Thus, in the Tg8 mice under conditions of the serotonin and noradrenaline excess, migration of the GnRH-neurons to their final anlage in hypothalamus is accelerated as well as the total number of the GnRH-neurons decreases, which indicates a decrease of proliferation of cells-precursors and the earlier differentiation of neurons.	Norepinephrine	60-73	gonadotropin releasing hormone 1	Mus musculus	99-103
10911894-0	2000	Dopamine, serotonin, and noradrenaline strongly inhibit the direct perforant path-CA1 synaptic input, but have little effect on the Schaffer collateral input.	Norepinephrine	25-38	carbonic anhydrase 1	Homo sapiens	82-85
17725036-7	2007	Thus, in the Tg8 mice under conditions of the serotonin and noradrenaline excess, migration of the GnRH-neurons to their final anlage in hypothalamus is accelerated as well as the total number of the GnRH-neurons decreases, which indicates a decrease of proliferation of cells-precursors and the earlier differentiation of neurons.	Norepinephrine	60-73	gonadotropin releasing hormone 1	Mus musculus	200-204
10820200-2	2000	In cells stably expressing alpha(1A)-adrenergic receptors, norepinephrine activated all five reporters [AP1 (activator protein-1), SRE (serum response element), CRE (cyclic AMP response element), NFkappaB) (nuclear factor-kappaB), and NFAT (nuclear factor of activated T cells)], whereas nerve growth factor (NGF) and epidermal growth factor activated only AP1 and SRE.	Norepinephrine	59-73	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	27-35
10820200-7	2000	inhibition of Src eliminated SRE responses to norepinephrine and NGF, and reduced all responses except CRE.	Norepinephrine	46-60	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	14-17
10854049-1	2000	Rab3B is a monomeric GTPase that modulates norepinephrine secretion when expressed in PC12 neuroendocrine cells.	Norepinephrine	43-57	RAB3B, member RAS oncogene family	Rattus norvegicus	0-5
17334639-6	2007	Investigations carried out in the rat show that galanin is also able to directly stimulate corticosterone (glucocorticoid) secretion from adrenocortical cells, through GAL-R1 and GAL-R2 coupled to the adenylate cyclase-protein kinase A signaling cascade, and nor-epinephrine release from adrenal medulla.	Norepinephrine	259-274	galanin receptor 1	Rattus norvegicus	168-185
10854049-4	2000	ZO-1 localization was not appreciably affected by the expression of a GTP binding mutant of rab3B (N135I) that stimulates norepinephrine secretion by PC12 cells.	Norepinephrine	122-136	RAB3B, member RAS oncogene family	Rattus norvegicus	92-97
17287146-1	2007	Limiting dopamine beta-monooxygenase results in lower norepinephrine (NE) and higher dopamine (DA) concentrations in copper-deficient Cu- tissues compared to copper-adequate Cu+ tissues.	Norepinephrine	54-68	dopamine beta-hydroxylase	Rattus norvegicus	9-36
10775486-2	2000	beta(1)-AR signaling, by the endogenous neurotransmitter norepinephrine, is central to the regulation of myocardial contractility.	Norepinephrine	57-71	adrenergic receptor, beta 1	Mus musculus	0-10
20409839-7	2007	In vitro studies indicate that renalase is a novel amine oxidase that specifically metabolizes circulating catecholamines including epinephrine and norepinephrine.	Norepinephrine	148-162	renalase, FAD dependent amine oxidase	Homo sapiens	31-39
17082254-2	2007	Treatment of pinealocytes with norepinephrine (NE) caused an increase in the mRNA and protein levels of MKP-1 and AA-NAT, as well as in the AA-NAT activity and melatonin production.	Norepinephrine	31-45	dual specificity phosphatase 1	Rattus norvegicus	104-109
17082254-2	2007	Treatment of pinealocytes with norepinephrine (NE) caused an increase in the mRNA and protein levels of MKP-1 and AA-NAT, as well as in the AA-NAT activity and melatonin production.	Norepinephrine	31-45	aralkylamine N-acetyltransferase	Rattus norvegicus	114-120
17082254-2	2007	Treatment of pinealocytes with norepinephrine (NE) caused an increase in the mRNA and protein levels of MKP-1 and AA-NAT, as well as in the AA-NAT activity and melatonin production.	Norepinephrine	31-45	aralkylamine N-acetyltransferase	Rattus norvegicus	140-146
17133078-4	2007	These systems allow bacteria to communicate across species boundaries, and the AI-3/epinephrine/norepinephrine system is involved in interkingdom signaling.	Norepinephrine	96-110	family with sequence similarity 83 member H	Homo sapiens	79-83
16959848-4	2006	The endogenous adrenergic neurotransmitter norepinephrine induced a potent increase in GLUT1 mRNA and a decrease of GLUT4 mRNA in mature brown adipocytes.	Norepinephrine	43-57	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	87-92
16959848-8	2006	Norepinephrine treatment led to a large increase of GLUT1 protein amount in brown adipocytes as visualized with immunocytochemical staining and subcellular fractionation.	Norepinephrine	0-14	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	52-57
16893531-2	2006	Because norepinephrine is an important regulator of spontaneous locomotor activity, we speculated that norepinephrine transporter blockade contributes to the effects of some antidepressants on spontaneous locomotor activity.	Norepinephrine	8-22	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Mus musculus	103-129
16788141-0	2006	Urea transporter UT-A1 and aquaporin-2 proteins decrease in response to angiotensin II or norepinephrine-induced acute hypertension.	Norepinephrine	90-104	aquaporin 2	Rattus norvegicus	27-38
16788141-7	2006	Norepinephrine (7 days) increased BP, urine volume, sodium excretion, and decreased urine osmolality and UT-A1, AQP2, and NKCC2/BSC1 abundances, similar to ANG II.	Norepinephrine	0-14	aquaporin 2	Rattus norvegicus	112-116
16788141-11	2006	We conclude that decreases in UT-A1, AQP2, and NKCC2/BSC1 proteins may contribute to the diuresis and natriuresis that occur following ANG II or norepinephrine-induced acute hypertension and do not appear to involve ANG II stimulation of aldosterone or thirst.	Norepinephrine	145-159	aquaporin 2	Rattus norvegicus	37-41
17027833-3	2006	This study examines the associations of beta2-adrenoceptor polymorphism with relationships between plasma norepinephrine (NE) and leptin to evaluate further the mechanisms of obesity.	Norepinephrine	106-120	leptin	Homo sapiens	130-136
16904088-4	2006	Treatment with EPO significantly reduced apoptosis induced by norepinephrine (NE) in the wild-type cardiomyocytes.	Norepinephrine	62-76	erythropoietin	Mus musculus	15-18
16735605-1	2006	Nicotine"s modulation of hippocampal noradrenergic neurotransmission may contribute to its mnemonic properties, but the nicotinic acetylcholine receptor (nAChR) subtypes that modulate terminal release of norepinephrine are unknown.	Norepinephrine	204-218	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	120-152
18079991-4	2006	Peripheral and central administration of IL-1 also induces norepinephrine (NE) release in the brain, most markedly in the hypothalamus.	Norepinephrine	59-73	interleukin 1 alpha	Homo sapiens	41-45
10737636-9	2000	These studies revealed that both CRLR and L1 were expressed only in cells that did not express PNMT, suggesting that adrenomedullin receptors are only found in noradrenaline-secreting cells.	Norepinephrine	160-173	adrenomedullin	Rattus norvegicus	117-131
10734146-6	2000	Both the alpha(2A)- and alpha(2C)-subtypes are important in the presynaptic inhibition of norepinephrine release and appear to have distinct regulatory roles.	Norepinephrine	90-104	adrenergic receptor, alpha 2c	Mus musculus	24-32
10773546-7	2000	Using LLC-PK(1) cells specifically expressing the individual transporter (i.e. dopamine [DAT], norepinephrine [NET], and SERT, respectively), ODAM showed a strong inhibition on SERT (K(i) = 0.12 +/- 0.02 nM).	Norepinephrine	95-109	odontogenic, ameloblast associated	Rattus norvegicus	142-146
10662890-0	2000	Protein kinase C-dependent inhibition of K+ currents in noradrenaline-induced depolarization of smooth muscle of guinea-pig vas deferens.	Norepinephrine	56-69	Prkca	Cavia porcellus	0-16
10607885-1	1999	Human alpha(1b)-adrenoceptors stably expressed (B(max) approximately 800 fmol/mg membrane protein) in mouse fibroblasts were able to increase intracellular Ca(2+) and inositol phosphate production in response to noradrenaline.	Norepinephrine	212-225	calcium channel, voltage-dependent, N type, alpha 1B subunit	Mus musculus	6-14
16712929-4	2006	Balb/c mice treated (i.p., twice, 16 h apart) with MPTP (30 mg/kg) or PRP-1 (1.6 mg/kg), but not PRP-4 (1.6 mg/kg) showed significant loss of striatal dopamine and norepinephrine as assayed by an HPLC-electrochemical procedure.	Norepinephrine	164-178	placental prolactin-related protein 1	Bos taurus	70-75
16829576-1	2006	Monoamine oxidase A (MAO A) degrades serotonin, norepinephrine, and dopamine and produces reactive oxygen that may cause neuronal cell death.	Norepinephrine	48-62	monoamine oxidase A	Homo sapiens	0-19
16829576-1	2006	Monoamine oxidase A (MAO A) degrades serotonin, norepinephrine, and dopamine and produces reactive oxygen that may cause neuronal cell death.	Norepinephrine	48-62	monoamine oxidase A	Homo sapiens	21-26
16762425-2	2006	This review focuses on the molecular function of two major classes of neurotransmitter transporter that are present in the cell membrane of neurons and/or glial cells: the solute carrier (SLC)1 transporter family, which includes the transporters that mediate the Na(+)-dependent uptake of glutamate, and the SLC6 transporter family, which includes the transporters that mediate the Na(+)-dependent uptake of dopamine, 5-HT, norepinephrine, glycine and GABA.	Norepinephrine	424-438	melanin concentrating hormone receptor 1	Homo sapiens	172-193
10543947-3	1999	SULT1A3 specifically sulfonates catecholamines such as dopamine, adrenaline and noradrenaline.	Norepinephrine	80-93	sulfotransferase family 1A member 3	Homo sapiens	0-7
10454495-8	1999	Contractile responses of the rabbit saphenous vein to both 5-HT(1A) receptor agonists were markedly inhibited by prazosin and dextrally shifted by WAY 100635, supporting the idea that the 5-HT(1A) receptor agonists were activating presynaptic 5-HT(1A) receptors to enhance norepinephrine release even in the absence of field stimulation.	Norepinephrine	273-287	5-hydroxytryptamine receptor 1A	Oryctolagus cuniculus	188-195
10454495-8	1999	Contractile responses of the rabbit saphenous vein to both 5-HT(1A) receptor agonists were markedly inhibited by prazosin and dextrally shifted by WAY 100635, supporting the idea that the 5-HT(1A) receptor agonists were activating presynaptic 5-HT(1A) receptors to enhance norepinephrine release even in the absence of field stimulation.	Norepinephrine	273-287	5-hydroxytryptamine receptor 1A	Oryctolagus cuniculus	188-195
10454495-10	1999	These observations suggested that serotonergic nerves or other cell types in the saphenous vein are activated by field stimulation to release serotonin, which in turn activates presynaptic 5-HT(1A) receptors on adrenergic neurons to effect norepinephrine release.	Norepinephrine	240-254	5-hydroxytryptamine receptor 1A	Oryctolagus cuniculus	189-196
10559681-1	1999	We tested the hypothesis that an elevated potassium-42 ((42)K(+)) efflux (highly dependent on Ca(2+)) and an increase in the sensitivity of contraction and (42)K(+) efflux to norepinephrine (NE) in conduit arteries of aldosterone-salt hypertensive rats (AHR) extended to smaller, distributing arteries.	Norepinephrine	175-189	aryl hydrocarbon receptor	Rattus norvegicus	254-257
10385678-1	1999	The recently identified transport proteins organic cation transporter 1 (OCT1), OCT2, and extraneuronal monoamine transporter (EMT) accept dopamine, noradrenaline, adrenaline, and 5-hydroxytryptamine as substrates and hence qualify as non-neuronal monoamine transporters.	Norepinephrine	149-162	POU class 2 homeobox 2	Homo sapiens	80-84
10385678-1	1999	The recently identified transport proteins organic cation transporter 1 (OCT1), OCT2, and extraneuronal monoamine transporter (EMT) accept dopamine, noradrenaline, adrenaline, and 5-hydroxytryptamine as substrates and hence qualify as non-neuronal monoamine transporters.	Norepinephrine	149-162	solute carrier family 22 member 3	Homo sapiens	90-125
10385678-1	1999	The recently identified transport proteins organic cation transporter 1 (OCT1), OCT2, and extraneuronal monoamine transporter (EMT) accept dopamine, noradrenaline, adrenaline, and 5-hydroxytryptamine as substrates and hence qualify as non-neuronal monoamine transporters.	Norepinephrine	149-162	solute carrier family 22 member 3	Homo sapiens	127-130
10431757-0	1999	Cannabinoid CB1 receptor-mediated inhibition of NMDA- and kainate-stimulated noradrenaline and dopamine release in the brain.	Norepinephrine	77-90	cannabinoid receptor 1	Rattus norvegicus	12-15
16696852-1	2006	Phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28) is the terminal enzyme of the catecholaminergic pathway converting noradrenaline to adrenaline.	Norepinephrine	126-139	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-38
16696852-1	2006	Phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28) is the terminal enzyme of the catecholaminergic pathway converting noradrenaline to adrenaline.	Norepinephrine	126-139	phenylethanolamine-N-methyltransferase	Rattus norvegicus	40-44
10431757-9	1999	In conclusion, activation of CB1 receptors inhibits the NMDA- and kainate-stimulated noradrenaline release in guinea-pig hippocampus and the NMDA-stimulated dopamine release in rat striatum.	Norepinephrine	85-98	cannabinoid receptor 1	Rattus norvegicus	29-32
10200422-2	1999	The release of [3H]-noradrenaline ([3H]-NA) in response to nicotinic acetylcholine receptor (nAChR) agonists was compared with agonist-induced currents in cultured rat superior cervical ganglion (SCG) neurones.	Norepinephrine	20-33	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	59-91
16580377-14	2006	CONCLUSION(S): This study demonstrated that ATP is a co-transmitter with noradrenaline in the contraction of the human vas deferens predominantly acting through the P2X1 receptor.	Norepinephrine	73-86	purinergic receptor P2X 1	Homo sapiens	165-178
16052243-3	2006	Since the neurotransmitter norepinephrine (NE) has both antidepressant and anticonvulsant properties, we speculated that NE transporter (NET) inhibitor antidepressants might be therapeutic candidates for comorbid individuals.	Norepinephrine	27-41	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Mus musculus	121-135
16052243-3	2006	Since the neurotransmitter norepinephrine (NE) has both antidepressant and anticonvulsant properties, we speculated that NE transporter (NET) inhibitor antidepressants might be therapeutic candidates for comorbid individuals.	Norepinephrine	27-41	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Mus musculus	137-140
16505658-1	2006	OBJECTIVES: To evaluate the potential differential effects of norepinephrine, an alpha1-, beta1-, and beta2-receptor agonist, to the alpha1-agonist phenylephrine on jejunal mucosal perfusion, gastric-arterial PCO2 gradient, and the global splanchnic oxygen demand-supply relationship after cardiac surgery.	Norepinephrine	62-76	adrenoceptor alpha 1D	Homo sapiens	133-139
16356685-4	2006	By contrast, knockout of the NE transporter (NET) gene, which elevates synaptic levels of norepinephrine, decreases seizure severity in mice fed normal diets.	Norepinephrine	90-104	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Mus musculus	29-43
16356685-4	2006	By contrast, knockout of the NE transporter (NET) gene, which elevates synaptic levels of norepinephrine, decreases seizure severity in mice fed normal diets.	Norepinephrine	90-104	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Mus musculus	45-48
10411311-2	1999	In the present study, the PKC isozymes expressed in rat pinealocytes and their regulation by norepinephrine (NE) were investigated.	Norepinephrine	93-107	protein kinase C, alpha	Rattus norvegicus	26-29
16423344-0	2006	[35S]GTPgammaS binding at the human dopamine D4 receptor variants hD4.2, hD4.4 and hD4.7 following stimulation by dopamine, epinephrine and norepinephrine.	Norepinephrine	140-154	dopamine receptor D4	Homo sapiens	36-56
16423344-8	2006	Agonism of norepinephrine and epinephrine at the dopamine D4 receptor may indicate an important way of cross-reactivity among the different monoamine neurotransmitter systems.	Norepinephrine	11-25	dopamine receptor D4	Homo sapiens	49-69
16412264-6	2006	However, relative to the normal saline group, in the norepinephrine-treated hearts, heart function, and myocardial ultrastructure deteriorated significantly, apoptosis and amount of Bax product increased significantly, and the ATP, phosphocreatine, and glycogen content decreased significantly, as did the amount of Bcl-2 product.	Norepinephrine	53-67	BCL2 associated X, apoptosis regulator	Rattus norvegicus	182-185
16380518-1	2006	An impairment of cardiac norepinephrine reuptake through the neuronal norepinephrine transporter promotes depletion of cardiac norepinephrine stores and local cardiac sympathetic activation in heart failure.	Norepinephrine	25-39	solute carrier family 6 member 2	Rattus norvegicus	70-96
16474208-3	2006	We investigated the role of JNK in the contractile response to norepinephrine (NE) in rat aortic smooth muscle.	Norepinephrine	63-77	mitogen-activated protein kinase 8	Rattus norvegicus	28-31
16931444-1	2006	Dopamine-beta-hydroxylase (DbetaH), the enzyme that synthesizes noradrenaline from dopamine, was studied in the locus coeruleus (LC) of neonate rats exposed to 2,4-dichlorophenoxyacetic acid (2,4-D) through lactation for 14 days (from PND 9 to 22).	Norepinephrine	64-77	dopamine beta-hydroxylase	Rattus norvegicus	0-25
16931444-1	2006	Dopamine-beta-hydroxylase (DbetaH), the enzyme that synthesizes noradrenaline from dopamine, was studied in the locus coeruleus (LC) of neonate rats exposed to 2,4-dichlorophenoxyacetic acid (2,4-D) through lactation for 14 days (from PND 9 to 22).	Norepinephrine	64-77	dopamine beta-hydroxylase	Rattus norvegicus	27-33
10079004-7	1999	The results suggest that contractions evoked by noradrenaline in both muscle types of human vas deferens is mediated via activation of alpha1-adrenoceptors with pharmacological profile of the alpha1A-subtype.	Norepinephrine	48-61	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	192-199
10022442-4	1999	In addition, circulating norepinephrine levels increased by 55 +/- 16% (P &lt; 0.02) 1 h after intracerebroventricular leptin administration, but did not increase after artificial cerebrospinal fluid administration.	Norepinephrine	25-39	leptin	Macaca mulatta	119-125
9927621-2	1999	In PC12 cells stably transfected with the human alpha-1A AR, norepinephrine (NE) strongly activated both extracellular signal regulated kinases (ERKs) and c-jun-NH2-terminal kinases (JNK).	Norepinephrine	61-75	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	48-56
9892008-3	1999	Norepinephrine activated PI 3-kinase in cells expressing human alpha1A and alpha1B via pertussis toxin-insensitive G proteins; alpha1D-receptors did not detectably activate this kinase.	Norepinephrine	0-14	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	63-70
10090125-8	1999	Norepinephrine-precontracted urethral rings of male guinea pigs exhibit a relaxation response at 10 Hz that is alpha1-adrenergic, non-cholinergic, non-purinergic, and independent of NPY.	Norepinephrine	0-14	pro-neuropeptide Y	Cavia porcellus	182-185
9856972-9	1998	We conclude that there is differential regulation of PKC isoform expression by D1-like agonists that inhibits membranous PKC-delta and PKC-zeta in WKY but stimulates them in SHR; this effect in SHR is similar to the stimulatory effect of norepinephrine and angiotensin II and may be a mechanism for their differential effects on sodium transport.	Norepinephrine	238-252	protein kinase C, alpha	Rattus norvegicus	53-56
9862381-1	1998	Neuropeptide Y (NPY) is both co-stored and co-released with noradrenaline from sympathetic nerve terminals.	Norepinephrine	60-73	neuropeptide Y	Canis lupus familiaris	0-14
9862381-1	1998	Neuropeptide Y (NPY) is both co-stored and co-released with noradrenaline from sympathetic nerve terminals.	Norepinephrine	60-73	neuropeptide Y	Canis lupus familiaris	16-19
9770549-1	1998	Norepinephrine (NE) and angiotensin II (Ang II), by promoting extracellular Ca2+ influx, increase Ca2+/calmodulin-dependent kinase II (CaMKII) activity, leading to activation of mitogen-activated protein kinase (MAPK) and cytosolic phospholipase A2 (cPLA2), resulting in release of arachidonic acid (AA) for prostacyclin synthesis in rabbit vascular smooth muscle cells.	Norepinephrine	0-14	cytosolic phospholipase A2	Oryctolagus cuniculus	222-248
9770549-1	1998	Norepinephrine (NE) and angiotensin II (Ang II), by promoting extracellular Ca2+ influx, increase Ca2+/calmodulin-dependent kinase II (CaMKII) activity, leading to activation of mitogen-activated protein kinase (MAPK) and cytosolic phospholipase A2 (cPLA2), resulting in release of arachidonic acid (AA) for prostacyclin synthesis in rabbit vascular smooth muscle cells.	Norepinephrine	0-14	cytosolic phospholipase A2	Oryctolagus cuniculus	250-255
9774489-0	1998	Role of endothelial-derived reactive oxygen species and nitric oxide in norepinephrine-induced rat aortic ring contractions.	Norepinephrine	72-86	mediator complex subunit 28	Rattus norvegicus	8-27
9774489-1	1998	In the present investigation involvement of endothelial-derived reactive oxygen species (ROS) and their interaction with nitric oxide (NO), during norepinephrine (NE)-induced contraction of rat aortic rings was studied.	Norepinephrine	147-161	mediator complex subunit 28	Rattus norvegicus	44-63
9650827-3	1998	A 0.1-ml bolus of 1 nmol human adrenomedullin is a potent inhibitor of the pressor response to exogenous norepinephrine infusion in an ex vivo canine tibia perfusion model for a duration of at least 70 min (P &lt; 0.005).	Norepinephrine	105-119	adrenomedullin	Homo sapiens	31-45
9861628-4	1998	The results indicate that: 1) CCK-33 enhances the influence of catecholamines: noradrenaline and isoprenaline, mainly on the function of isolated heart.	Norepinephrine	79-92	cholecystokinin	Rattus norvegicus	30-33
9730267-0	1998	The role of MAO-A and MAO-B in the metabolic degradation of noradrenaline in human arteries.	Norepinephrine	60-73	monoamine oxidase B	Homo sapiens	22-27
17184598-5	2006	DBH is an enzyme responsible for the conversion of dopamine into noradrenaline.	Norepinephrine	65-78	dopamine beta-hydroxylase	Homo sapiens	0-3
9512271-11	1998	The functional role of GAL may be related to noradrenaline, possibly by a presynaptic action.	Norepinephrine	45-58	galanin and GMAP prepropeptide	Homo sapiens	23-26
16139427-1	2005	Monoamine oxidase A (MAO-A) is an enzyme involved in the metabolism of monoamine neurotransmitters such as dopamine, serotonin, and noradrenaline in the brain.	Norepinephrine	132-145	monoamine oxidase A	Homo sapiens	0-19
16139427-1	2005	Monoamine oxidase A (MAO-A) is an enzyme involved in the metabolism of monoamine neurotransmitters such as dopamine, serotonin, and noradrenaline in the brain.	Norepinephrine	132-145	monoamine oxidase A	Homo sapiens	21-26
16358768-2	2005	Administration of alpha-methyl-para-tyrosine led to decreased levels of dopamine and noradrenaline in the areas of migration of GnRH-neurons in fetuses on days 17 and 21 of prenatal development.	Norepinephrine	85-98	gonadotropin releasing hormone 1	Rattus norvegicus	128-132
15975715-2	2005	After 14 postnatal days, concentrations of biogenic amines were smaller in mecp2-null mice than those in control mice and at 42 postnatal days, norepinephrine, dopamine and serotonin concentrations in mecp2-null mice were significantly smaller by 25, 24 and 16%, respectively.	Norepinephrine	144-158	methyl CpG binding protein 2	Mus musculus	201-206
16211406-1	2005	The non-neuronal monoamine transporters OCT1, OCT2 and EMT (human gene symbols SLC22A1-A3) efficiently transport a number of positively-charged monoamines and some small organic cations across the plasma membrane, and thus are implicated in the inactivation of released monoamine transmitters (e.g. noradrenaline, histamine, agmatine) in vivo.	Norepinephrine	299-312	solute carrier family 22 member 2	Homo sapiens	46-50
16211406-1	2005	The non-neuronal monoamine transporters OCT1, OCT2 and EMT (human gene symbols SLC22A1-A3) efficiently transport a number of positively-charged monoamines and some small organic cations across the plasma membrane, and thus are implicated in the inactivation of released monoamine transmitters (e.g. noradrenaline, histamine, agmatine) in vivo.	Norepinephrine	299-312	IL2 inducible T cell kinase	Homo sapiens	55-58
15964316-1	2005	Norepinephrine (NE) stimulates phospholipase D (PLD) activity via phospholipase A2-dependent arachidonic acid release in rabbit aortic vascular smooth muscle cells (VSMC).	Norepinephrine	0-14	phospholipase A2	Oryctolagus cuniculus	66-82
9548392-12	1998	These data suggest that endogenous PAF contributes to the vascular hyporeactivity to noradrenaline induced by endotoxin and that NO plays a major role in the endotoxin-induced hyporeactivity.	Norepinephrine	85-98	PCNA clamp associated factor	Rattus norvegicus	35-38
7753398-8	1995	Replacing Ca2+ with Mg2+ or adding 0.8 mM of Cd2+ reversibly blocked the norepinephrine effects.	Norepinephrine	73-87	Cd2 molecule	Rattus norvegicus	45-48
7864642-8	1995	These results suggest that laparotomy releases glucocorticoids and neural noradrenaline that stimulates alpha 1-adrenergic receptors, thereby leading to the serine dehydratase gene expression.	Norepinephrine	74-87	serine dehydratase	Rattus norvegicus	157-175
15850450-1	2005	BACKGROUND INFORMATION: NPY (neuropeptide Y) may have an effect on the properties of vascular endothelial cells such as pro-angiogenic effects and potentiation of noradrenaline-induced vasoconstriction.	Norepinephrine	163-176	neuropeptide Y	Homo sapiens	24-27
15850450-1	2005	BACKGROUND INFORMATION: NPY (neuropeptide Y) may have an effect on the properties of vascular endothelial cells such as pro-angiogenic effects and potentiation of noradrenaline-induced vasoconstriction.	Norepinephrine	163-176	neuropeptide Y	Homo sapiens	29-43
15929740-3	2005	We also studied the effects of altered body weight on expression of dopamine beta-hydroxylase (DBH), the enzyme that produces noradrenalin from dopamine.	Norepinephrine	126-138	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	Ovis aries	68-93
15929740-3	2005	We also studied the effects of altered body weight on expression of dopamine beta-hydroxylase (DBH), the enzyme that produces noradrenalin from dopamine.	Norepinephrine	126-138	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	Ovis aries	95-98
15857612-5	2005	Ca(2+) sensitization induced by phenylephrine, norepinephrine and carbachol was markedly antagonized by all three ROK inhibitors.	Norepinephrine	47-61	Rho-associated coiled-coil containing protein kinase 2	Rattus norvegicus	114-117
15626688-0	2005	Norepinephrine induces endoplasmic reticulum stress and downregulation of norepinephrine transporter density in PC12 cells via oxidative stress.	Norepinephrine	0-14	solute carrier family 6 member 2	Rattus norvegicus	74-100
15661972-7	2005	Urinary norepinephrine excretion was higher in RGS2-/-than in RGS2+/+mice.	Norepinephrine	8-22	regulator of G-protein signaling 2	Mus musculus	47-51
15661972-7	2005	Urinary norepinephrine excretion was higher in RGS2-/-than in RGS2+/+mice.	Norepinephrine	8-22	regulator of G-protein signaling 2	Mus musculus	62-66
15841207-5	2005	Here we report the identification of a novel flavin adenine dinucleotide-dependent amine oxidase (renalase) that is secreted into the blood by the kidney and metabolizes catecholamines in vitro (renalase metabolizes dopamine most efficiently, followed by epinephrine, and then norepinephrine).	Norepinephrine	277-291	renalase, FAD dependent amine oxidase	Homo sapiens	98-106
15841207-5	2005	Here we report the identification of a novel flavin adenine dinucleotide-dependent amine oxidase (renalase) that is secreted into the blood by the kidney and metabolizes catecholamines in vitro (renalase metabolizes dopamine most efficiently, followed by epinephrine, and then norepinephrine).	Norepinephrine	277-291	renalase, FAD dependent amine oxidase	Homo sapiens	195-203
15671203-4	2005	MAO-A activity was estimated by measuring concentrations of 3,4-dihydroxyphenylglycol (DHPG), a stable metabolite of norepinephrine.	Norepinephrine	117-131	monoamine oxidase A	Homo sapiens	0-5
15930502-5	2005	In mice lacking norepinephrine and epinephrine, many of these regions exhibited significantly reduced activation (e.g., hippocampal CA1), while other regions did not (e.g., hippocampal CA3).	Norepinephrine	16-30	carbonic anhydrase 1	Mus musculus	132-135
15809019-12	2005	Myocardial content of noradrenaline was lower in the GFAP-bGH group (p&lt;0.05).	Norepinephrine	22-35	glial fibrillary acidic protein	Mus musculus	53-57
15615865-7	2005	In functional studies, coexpression with beta2-AR significantly enhanced the coupling of alpha1D-AR to norepinephrine-stimulated Ca2+ mobilization.	Norepinephrine	103-117	adrenoceptor alpha 1D	Homo sapiens	89-99
7830064-1	1995	Cyclic GMP accumulation in pinealocytes is elevated &gt; 100-fold by norepinephrine (NE) through a mechanism involving conjoint activation of alpha 1- and beta 1-adrenergic receptors.	Norepinephrine	69-83	5'-nucleotidase, cytosolic II	Homo sapiens	7-10
7730990-13	1995	injection of CCK increased the concentrations in the dialysate of noradrenaline and serotonin, but not of either adrenaline or dopamine.	Norepinephrine	66-79	cholecystokinin	Rattus norvegicus	13-16
7730990-17	1995	Inclusion of morphine in the dialysate also blocked the increase in noradrenaline and serotonin in response to CCK in a naloxone-reversible manner.	Norepinephrine	68-81	cholecystokinin	Rattus norvegicus	111-114
7730990-19	1995	These observations indicate that morphine acts near or within the supraoptic nucleus to block CCK-evoked noradrenaline release presynaptically.	Norepinephrine	105-118	cholecystokinin	Rattus norvegicus	94-97
7867036-7	1994	The response was time and concentration dependent with the maximal increase at 12 min, EC50 5.3 x 10(-9) M, and maximum effect at 10(-6) M. Both noradrenalin and endothelin-1 stimulated phosphatidylbutanol production in the presence of butanol (100 mM), indicating that both agonists activate phospholipase D. CONCLUSIONS: Noradrenaline at physiological concentrations elicits both a rapid and a delayed increase in phosphatidic acid in adult rabbit ventricular myocytes.	Norepinephrine	323-336	endothelin-1	Oryctolagus cuniculus	162-174
15669056-10	2005	Some long projection neurons such as the pyramidal, mitral, principal neurons of several cranial nuclei, and presumably monoaminergic cells containing noradrenalin, dopamine, and serotonin, expressed high levels of L1cam.	Norepinephrine	151-163	L1 cell adhesion molecule	Mus musculus	215-220
7995014-2	1994	Although not all features of its antiParkinson action are known, studies that used brains obtained at autopsy from patients who took l-deprenyl show that the selective inhibition of MAO-B with a concomitant increase of phenylethylamine and dopamine, but not of serotonin or noradrenaline, in the basal ganglia may be responsible for its mode of action.	Norepinephrine	274-287	monoamine oxidase B	Homo sapiens	182-187
15813642-8	2005	Furthermore, antagonism or genetic inactivation of the NK1R causes alterations in serotonin and norepinephrine neuronal transmission that are likely to contribute to the antidepressant/anxiolytic activity of NK1R antagonists but that are--at least partially--distinct from those produced by established antidepressant drugs.	Norepinephrine	96-110	tachykinin receptor 1	Homo sapiens	55-59
15813642-8	2005	Furthermore, antagonism or genetic inactivation of the NK1R causes alterations in serotonin and norepinephrine neuronal transmission that are likely to contribute to the antidepressant/anxiolytic activity of NK1R antagonists but that are--at least partially--distinct from those produced by established antidepressant drugs.	Norepinephrine	96-110	tachykinin receptor 1	Homo sapiens	208-212
15306634-0	2005	Histamine H3-receptor-induced attenuation of norepinephrine exocytosis: a decreased protein kinase a activity mediates a reduction in intracellular calcium.	Norepinephrine	45-59	histamine receptor H3	Homo sapiens	0-21
7839857-3	1994	Two series of experiments were performed on vessels: the dose-response relationship of PACAP-38 (10(-10)-10(-7) M) was established on noradrenaline- (NA, 10(-6) M) contracted vessels.	Norepinephrine	134-147	LOW QUALITY PROTEIN: pituitary adenylate cyclase-activating polypeptide	Oryctolagus cuniculus	87-92
7882162-2	1994	We now demonstrated that the addition of elastin peptides to rat aorta rings precontracted with noradrenaline produced an endothelium-dependent vasorelaxation.	Norepinephrine	96-109	elastin	Rattus norvegicus	41-48
16075814-5	2005	UCP1 is only expressed in BAT through the synergistic action of norepinephrine (NE) and thyroid hormones in animals exposed to cold and to a lesser degree after meals.	Norepinephrine	64-78	uncoupling protein 1	Homo sapiens	0-4
7947060-1	1994	Neuropeptide Y (NPY) is a potent vasoconstrictive polypeptide colocalized with norepinephrine in sympathetic neurons.	Norepinephrine	79-93	neuropeptide Y	Canis lupus familiaris	0-14
7947060-1	1994	Neuropeptide Y (NPY) is a potent vasoconstrictive polypeptide colocalized with norepinephrine in sympathetic neurons.	Norepinephrine	79-93	neuropeptide Y	Canis lupus familiaris	16-19
7921614-13	1994	It is concluded that PKA activation is involved in the noradrenaline release enhancing effect of the two 8-substituted cyclic GMP analogues, whereas a cyclic GMP/PKG-operated pathway accounts for the inhibitory effects of the cyclic GMP and its analogues on vascular smooth muscle contraction.	Norepinephrine	55-68	5'-nucleotidase, cytosolic II	Homo sapiens	126-129
8187273-1	1994	It is well-documented that norepinephrine (NE) induces the expression of immediate-early genes (IEGs), such as c-fos, c-jun, and jun-B, in cultured neonatal heart cells and leads to cell growth without cell division (ie, hypertrophy).	Norepinephrine	27-41	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	111-116
8187273-1	1994	It is well-documented that norepinephrine (NE) induces the expression of immediate-early genes (IEGs), such as c-fos, c-jun, and jun-B, in cultured neonatal heart cells and leads to cell growth without cell division (ie, hypertrophy).	Norepinephrine	27-41	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	118-123
8032591-12	1994	In hD2-transfected cells, but not untransfected cells, high-threshold currents were depressed by quinpirole (30 +/- 4% at 100 nM; n = 15) with a pEC50 of 8.61 +/- 0.22 (n = 5), as well as by (-)-noradrenaline (28 +/- 5% at 1 microM, n = 9).	Norepinephrine	191-208	immunoglobulin heavy diversity 2-15	Homo sapiens	3-6
8045100-2	1994	Intravenous infusion of noradrenaline (0.5 microgram/kg per min for 2 hr) totally suppressed plasma GH concentrations.	Norepinephrine	24-37	somatotropin	Ovis aries	100-102
8045100-3	1994	Concomitant treatment of animals with the beta-adrenergic antagonist propranolol completely blocked the noradrenaline-induced suppression of GH.	Norepinephrine	104-117	somatotropin	Ovis aries	141-143
8045100-5	1994	To further investigate the central adrenergic regulation of GH secretion 10 micrograms of noradrenaline or adrenaline was microinjected (1 microliter) directly into the preoptic area of the hypothalamus of ovariectomized ewes.	Norepinephrine	90-103	somatotropin	Ovis aries	60-62
8045100-6	1994	When the time of injection coincided with a GH trough period, both noradrenaline and adrenaline caused an increase in plasma GH concentrations, whereas if the injection coincided with an endogenous pulse of GH no additional GH response was obtained.	Norepinephrine	67-80	somatotropin	Ovis aries	44-46
8045100-6	1994	When the time of injection coincided with a GH trough period, both noradrenaline and adrenaline caused an increase in plasma GH concentrations, whereas if the injection coincided with an endogenous pulse of GH no additional GH response was obtained.	Norepinephrine	67-80	somatotropin	Ovis aries	125-127
8045100-6	1994	When the time of injection coincided with a GH trough period, both noradrenaline and adrenaline caused an increase in plasma GH concentrations, whereas if the injection coincided with an endogenous pulse of GH no additional GH response was obtained.	Norepinephrine	67-80	somatotropin	Ovis aries	125-127
8045100-6	1994	When the time of injection coincided with a GH trough period, both noradrenaline and adrenaline caused an increase in plasma GH concentrations, whereas if the injection coincided with an endogenous pulse of GH no additional GH response was obtained.	Norepinephrine	67-80	somatotropin	Ovis aries	125-127
8138103-8	1993	Norepinephrine which might leak from varicosities of chromatic nerve fibers by virtue of the action of prolactin molecules may be responsible for melanosome aggregation.	Norepinephrine	0-14	prolactin	Oreochromis niloticus	103-112
7511425-0	1993	Comparative effects of bradykinin and atrial natriuretic factor on neuronal and non-neuronal noradrenaline uptake in the central nervous system of the rat.	Norepinephrine	93-106	natriuretic peptide A	Rattus norvegicus	38-63
8234284-5	1993	In the present experiments, microinjection of norepinephrine into the AV3V region induced natriuresis and an increase in plasma ANP.	Norepinephrine	46-60	natriuretic peptide A	Rattus norvegicus	128-131
7902002-5	1993	Insulin infusion resulted in hyperinsulinemic-hypoglycemia, a surge in epinephrine and norepinephrine concentration, and increases in the combined ventricular output and regional blood flow to the heart, adrenal glands, kidney, gastrointestinal tract, liver, fat, muscle, carcass, and placenta.	Norepinephrine	87-101	LOC105613195	Ovis aries	0-7
8277975-6	1993	Adenosine deaminase at the concentration of 0.5 mu.ml-1 decreased but at that of 2.0 mu.ml-1 increased noradrenaline overflow.	Norepinephrine	103-116	adenosine deaminase	Rattus norvegicus	0-19
8106008-0	1993	Norepinephrine-stimulated PI hydrolysis in oligodendrocytes is mediated by alpha 1A-adrenoceptors.	Norepinephrine	0-14	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	75-83
8405122-5	1993	The inhibitory effect of these agents on the KCl-, norepinephrine-and phorbol 12,13-dibutyrate-induced contractions showed good correlations to the concentrations of the agents producing 50% inhibition (IC50) of cyclic GMP-inhibited cyclic nucleotide phosphodiesterase.	Norepinephrine	51-65	phosphodiesterase 3A	Rattus norvegicus	233-268
8336141-6	1993	Histamine-stimulated catecholamine secretion was also greater in epinephrine cells than in norepinephrine cells, whereas high K+, bradykinin, phorbol 12,13-dibutyrate, and angiotensin II all caused greater secretion from norepinephrine cells than from epinephrine cells.	Norepinephrine	221-235	kininogen 1	Bos taurus	130-140
8500726-8	1993	Intravenous infusion of VIP and norepinephrine inhibited CCK-induced gallbladder contraction and these responses were abolished dose dependently by intravenous infusion of (4Cl-D-Phe6-Leu17)VIP and phentolamine, respectively.	Norepinephrine	32-46	cholecystokinin	Canis lupus familiaris	57-60
8232769-10	1993	This embryonic GR may modulate the development of inter alia neuro-endocrine areas such as the paraventricular and arcuate nuclei and arousal-related areas such as the central 5-hydroxytryptamine and noradrenaline neuronal systems.	Norepinephrine	200-213	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	15-17
16110245-1	2005	Monoamine oxidase A (MAOA), a mitochondrial outer membrane enzyme, degrades biogenic amines including norepinephrine, dopamine and serotonin, which have been implicated in the expression of personality traits.	Norepinephrine	102-116	monoamine oxidase A	Homo sapiens	0-19
16110245-1	2005	Monoamine oxidase A (MAOA), a mitochondrial outer membrane enzyme, degrades biogenic amines including norepinephrine, dopamine and serotonin, which have been implicated in the expression of personality traits.	Norepinephrine	102-116	monoamine oxidase A	Homo sapiens	21-25
8491504-3	1993	Under control conditions, infusion of norepinephrine (10-40 ng/min per milliliter per minute of control renal blood flow) increased plasma renin activity and decreased renal blood flow progressively by approximately 10-75%.	Norepinephrine	38-52	renin	Canis lupus familiaris	139-144
7689357-0	1993	Atrial natriuretic peptide and bradykinin interaction on norepinephrine uptake in rat adrenal medulla.	Norepinephrine	57-71	natriuretic peptide A	Rattus norvegicus	0-26
15613462-8	2004	Over-expression of the hypoxia-inducible transcription factor, HIF-2alpha, in norepinephrine-predominant sporadic and VHL tumors compared with epinephrine-producing tumors indicates that expression of this gene depends on the noradrenergic biochemical phenotype.	Norepinephrine	78-92	endothelial PAS domain protein 1	Homo sapiens	63-73
15613462-9	2004	The findings fit with the known expression of HIF-2alpha in norepinephrine-producing cells of the sympathetic nervous system and might explain both the development and noradrenergic biochemical phenotype of pheochromocytomas in VHL syndrome.	Norepinephrine	60-74	endothelial PAS domain protein 1	Homo sapiens	46-56
7689357-1	1993	Interactions between atrial natriuretic peptide (ANP) and bradykinin (BDK) on norepinephrine (NE) uptake were demonstrated in the adrenal medulla of the rat.	Norepinephrine	78-92	natriuretic peptide A	Rattus norvegicus	21-47
8380260-9	1993	We conclude, therefore, that the inhibitory effects of antecedent sympathetic release stimulation on cardiac sympathetic neurotransmission are mediated prejunctionally, probably via an inhibition of the neuronal release of norepinephrine by neuropeptide Y.	Norepinephrine	223-237	neuropeptide Y	Canis lupus familiaris	241-255
15527789-0	2004	Mitogen-activated protein kinase phosphatase-1 (MKP-1): &gt;100-fold nocturnal and norepinephrine-induced changes in the rat pineal gland.	Norepinephrine	83-97	dual specificity phosphatase 1	Rattus norvegicus	0-46
15527789-0	2004	Mitogen-activated protein kinase phosphatase-1 (MKP-1): &gt;100-fold nocturnal and norepinephrine-induced changes in the rat pineal gland.	Norepinephrine	83-97	dual specificity phosphatase 1	Rattus norvegicus	48-53
15527789-1	2004	The norepinephrine-driven increase in mitogen-activated protein kinase (MAPK) activity is part of the mechanism that regulates arylalkylamine N-acetyltransferase (AA-NAT) activity in the rat pineal gland.	Norepinephrine	4-18	aralkylamine N-acetyltransferase	Rattus norvegicus	127-161
15527789-1	2004	The norepinephrine-driven increase in mitogen-activated protein kinase (MAPK) activity is part of the mechanism that regulates arylalkylamine N-acetyltransferase (AA-NAT) activity in the rat pineal gland.	Norepinephrine	4-18	aralkylamine N-acetyltransferase	Rattus norvegicus	163-169
15527789-3	2004	MKP-1 expression was regulated by norepinephrine acting through both alpha- and beta-adrenergic receptors.	Norepinephrine	34-48	dual specificity phosphatase 1	Rattus norvegicus	0-5
1473014-4	1992	Administration of IRAP largely prevented the effects of IL-1 alpha or IL-1 beta on the elevation of plasma corticosterone and the concomitant increase in hypothalamic norepinephrine metabolism, but failed to alter the responses to LPS.	Norepinephrine	167-181	interleukin 1 receptor antagonist	Mus musculus	18-22
15662096-1	2004	Dopamine beta-hydroxylase (DBH) which catalyzes conversion of dopamine into noradrenaline, may be a good blood marker of unipolar depression.	Norepinephrine	76-89	dopamine beta-hydroxylase	Rattus norvegicus	0-25
1429734-7	1992	The addition of PKC enhanced phosphorylation of p145 under conditions of fully reconstituted Ca(2+)-activated norepinephrine secretion.	Norepinephrine	110-124	POM121 transmembrane nucleoporin	Rattus norvegicus	48-52
15662096-1	2004	Dopamine beta-hydroxylase (DBH) which catalyzes conversion of dopamine into noradrenaline, may be a good blood marker of unipolar depression.	Norepinephrine	76-89	dopamine beta-hydroxylase	Rattus norvegicus	27-30
1358654-2	1992	Seven days after the intracerebroventricular administration of 0.25 and 0.5 mumol 2,4,5-trihydroxyamphetamine, hippocampal tryptophan hydroxylase (TPH) activity was reduced to 5 and 1% of control, respectively, while norepinephrine (NE) concentration was depressed to 10 and 18% of control.	Norepinephrine	217-231	tryptophan hydroxylase 1	Rattus norvegicus	147-150
1333978-2	1992	The effectiveness of electrical stimulation of the locus coeruleus and of microiontophoretic application of norepinephrine (NE) in suppressing the firing activity of CA3 pyramidal neurons was studied in the dorsal hippocampus.	Norepinephrine	108-122	carbonic anhydrase 3	Rattus norvegicus	166-169
1436127-8	1992	The time-course of the development of changes in CCK-8 binding paralleled with some lag the development of changes in noradrenaline uptake.	Norepinephrine	118-131	cholecystokinin	Rattus norvegicus	49-52
1279289-4	1992	beta 1-Adrenoceptor-mediated effects were isoprenaline (ISO) infusion-induced increase in systolic blood pressure (SBP) and bicycle exercise-induced increase in heart rate (HR); beta 2-adrenoceptor-mediated effects were ISO infusion-induced increase in plasma norepinephrine (NE) and decrease in diastolic blood pressure (DBP); ISO infusion-induced increase in HR was assessed as mixed beta 1- and beta 2-adrenoceptor-mediated effect.	Norepinephrine	260-274	adrenoceptor beta 2	Homo sapiens	178-197
1279294-6	1992	Thus, NPY, which is colocalized not only with norepinephrine in sympathetic perivascular fibers but also with VIP and ACh in some parasympathetic neurons, can greatly reduce the vasodilatory effect of ACh and VIP, as well as of the sensory peptide SP.	Norepinephrine	46-60	pro-neuropeptide Y	Cavia porcellus	6-9
1301634-0	1992	Effects of atrial natriuretic peptide, angiotensin II and III on norepinephrine uptake in the rat adrenal medulla.	Norepinephrine	65-79	natriuretic peptide A	Rattus norvegicus	11-37
1300039-2	1992	NPY microinjection (1.5 micrograms) also produced marked decreases in noradrenaline (5 +/- 4 pmol.ml-1) and adrenaline (23 +/- 8 pmol.ml-1), but no significant change in dopamine in blood plasma.	Norepinephrine	70-83	neuropeptide Y	Felis catus	0-3
15505174-1	2004	Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine (NE).	Norepinephrine	72-86	dopamine beta-hydroxylase	Homo sapiens	0-25
15505174-1	2004	Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine (NE).	Norepinephrine	72-86	dopamine beta-hydroxylase	Homo sapiens	27-30
15509759-1	2004	The neuropeptide corticotropin-releasing hormone (CRH) activates locus ceruleus (LC) neurons, thereby increasing norepinephrine levels throughout the CNS.	Norepinephrine	113-127	corticotropin releasing hormone	Homo sapiens	17-48
15509759-1	2004	The neuropeptide corticotropin-releasing hormone (CRH) activates locus ceruleus (LC) neurons, thereby increasing norepinephrine levels throughout the CNS.	Norepinephrine	113-127	corticotropin releasing hormone	Homo sapiens	50-53
1300039-3	1992	The results suggest that the depressor effect of NPY in A1 noradrenergic nucleus may be realized by not only reducing the release of noradrenaline in sympathetic terminals around the peripheral vascular beds but also inhibiting the sympathetico-adrenal system.	Norepinephrine	133-146	neuropeptide Y	Felis catus	49-52
1392057-6	1992	injection of increasing doses of endothelin-1 (ET) (0.01-0.3 microgram) caused a weak but long-lasting and dose-dependent vasoconstriction of the thoracic aorta; its effect was less potent than that of angiotensin II or norepinephrine when their peak responses were compared.	Norepinephrine	220-234	endothelin-1	Oryctolagus cuniculus	33-45
1392057-6	1992	injection of increasing doses of endothelin-1 (ET) (0.01-0.3 microgram) caused a weak but long-lasting and dose-dependent vasoconstriction of the thoracic aorta; its effect was less potent than that of angiotensin II or norepinephrine when their peak responses were compared.	Norepinephrine	220-234	endothelin-1	Oryctolagus cuniculus	47-49
1325876-2	1992	Stimulation of the adult gland with norepinephrine elevates both cyclic AMP and cyclic GMP production, through remarkably similar mechanisms requiring activation of both beta- and alpha 1-adrenergic receptors.	Norepinephrine	36-50	5'-nucleotidase, cytosolic II	Homo sapiens	87-90
15464018-4	2004	In addition, the detection of the diverse receptor populations for ATP, noradrenaline and NPY in blood vessels, either in the smooth muscle, endothelial cells or nerve endings, further contribute to the notion that sympathetic vascular reflexes encompass the orchestrated action of the noradrenaline and ATP, and their modulation by NPY.	Norepinephrine	286-299	neuropeptide Y	Homo sapiens	90-93
15464018-4	2004	In addition, the detection of the diverse receptor populations for ATP, noradrenaline and NPY in blood vessels, either in the smooth muscle, endothelial cells or nerve endings, further contribute to the notion that sympathetic vascular reflexes encompass the orchestrated action of the noradrenaline and ATP, and their modulation by NPY.	Norepinephrine	286-299	neuropeptide Y	Homo sapiens	333-336
15363956-0	2004	Brain phospholipase C-diacylglycerol lipase pathway is involved in vasopressin-induced release of noradrenaline and adrenaline from adrenal medulla in rats.	Norepinephrine	98-111	lipase G, endothelial type	Rattus norvegicus	13-19
15363956-13	2004	These results suggest that vasopressin evokes the release of noradrenaline and adrenaline from adrenal medulla by the brain PLC- and diacylglycerol lipase-dependent mechanisms in rats.	Norepinephrine	61-74	lipase G, endothelial type	Rattus norvegicus	148-154
15356201-0	2004	Uptake and release of norepinephrine by serotonergic terminals in norepinephrine transporter knock-out mice: implications for the action of selective serotonin reuptake inhibitors.	Norepinephrine	22-36	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Mus musculus	66-92
15262904-6	2004	Blockade of norepinephrine transporter or alpha2-adrenoceptors using desipramine or rauwolscine reduced the losartan-induced shifts in the ED50 values of noradrenaline by 63% and 21%, respectively.	Norepinephrine	154-167	solute carrier family 6 member 2	Rattus norvegicus	12-38
15262904-7	2004	Combined blockade of norepinephrine transporter and alpha2-adrenoceptors eliminated the influence of losartan on noradrenaline sensitivity (ED50 5.5+/-1.3 versus 5.6+/-1.2 nmol/kg), a result also observed after sympathetic denervation by reserpine (ED50 7.1+/-0.8 versus 7.8+/-0.8 nmol/kg).	Norepinephrine	113-126	solute carrier family 6 member 2	Rattus norvegicus	21-47
15262904-8	2004	Our experiments show that the reduction of vascular noradrenaline sensitivity by AT1 blockade is dependent on the intact functioning of both neuronal noradrenaline uptake via norepinephrine transporter and presynaptic alpha2-mediated autoinhibition, exclusively provided by the sympathetic innervation.	Norepinephrine	52-65	solute carrier family 6 member 2	Rattus norvegicus	175-201
15262904-8	2004	Our experiments show that the reduction of vascular noradrenaline sensitivity by AT1 blockade is dependent on the intact functioning of both neuronal noradrenaline uptake via norepinephrine transporter and presynaptic alpha2-mediated autoinhibition, exclusively provided by the sympathetic innervation.	Norepinephrine	150-163	solute carrier family 6 member 2	Rattus norvegicus	175-201
15262269-5	2004	Furthermore, in a different model of serotonergic and noradrenergic degeneration, BDNF protein levels were similarly increased in response to depletions in hippocampal serotonin and norepinephrine caused by the chemical neurotoxin 1-methyl-4-(2"-aminophenyl)-1,2,3,6-tetrahydropyridine (2"-NH2-MPTP).	Norepinephrine	182-196	brain derived neurotrophic factor	Mus musculus	82-86
1385164-4	1992	In addition to its contractile activity, NPY greatly reduced the maximal response to vasoactive intestinal peptide (VIP), noradrenaline (NA), substance P (SP) and 5-hydroxytryptamine (5-HT), without affecting their pD2 values.	Norepinephrine	122-135	pro-neuropeptide Y	Cavia porcellus	41-44
1629106-6	1992	The catecholamine- (epinephrine plus norepinephrine) to-insulin molar ratio was correlated with Ra during the early period (r = 0.52, P less than 0.01) and over the entire period of exercise (r = 0.66, P less than 0.0001).	Norepinephrine	37-51	insulin	Canis lupus familiaris	56-63
1377629-0	1992	Modulation of hypothalamic norepinephrine release by atrial natriuretic peptide: involvement of cyclic GMP.	Norepinephrine	27-41	natriuretic peptide A	Rattus norvegicus	53-79
15173897-0	2004	Impact of substance P receptor antagonism on the serotonin and norepinephrine systems: relevance to the antidepressant/anxiolytic response.	Norepinephrine	63-77	tachykinin receptor 1	Rattus norvegicus	10-30
15127327-16	2004	A significant (p &lt; 0.001) increase in IN/ME perfusate concentrations of dopamine and noradrenaline metabolites was noted in PRL-treated ewes in comparison with those in the control.	Norepinephrine	88-101	prolactin	Ovis aries	127-130
14736843-0	2004	M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals.	Norepinephrine	46-60	potassium voltage-gated channel subfamily Q member 2	Rattus norvegicus	22-27
1716066-1	1991	Norepinephrine and four families of neuropeptides, namely, neuropeptide Y (NPY), opioid peptides, galanin, and growth hormone-releasing factor (GRH), have been shown to stimulate feeding after central administration.	Norepinephrine	0-14	neuropeptide Y	Canis lupus familiaris	59-73
14741406-8	2004	These data show that the expression of Per1 and Cry2 in the rat pineal gland is regulated by the clock-driven changes in norepinephrine, in a similar manner to the melatonin rhythm-generating enzyme arylalkylamine N-acetyltransferase.	Norepinephrine	121-135	cryptochrome circadian regulator 2	Rattus norvegicus	48-52
15539858-2	2004	Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine.	Norepinephrine	108-122	monoamine oxidase A	Homo sapiens	0-19
1716066-1	1991	Norepinephrine and four families of neuropeptides, namely, neuropeptide Y (NPY), opioid peptides, galanin, and growth hormone-releasing factor (GRH), have been shown to stimulate feeding after central administration.	Norepinephrine	0-14	neuropeptide Y	Canis lupus familiaris	75-78
15539858-2	2004	Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine.	Norepinephrine	108-122	monoamine oxidase A	Homo sapiens	21-25
1861148-6	1991	These observations contrast with those in another report in which we showed that bradykinin stimulation of either [32P]phosphatidic acid accumulation or noradrenaline release is not affected by R 59 022.	Norepinephrine	153-166	kininogen 1	Bos taurus	81-91
14697876-10	2004	MAO-A oxidizes noradrenaline and serotonin; and MAO-B, mainly beta-phenylethylamine.	Norepinephrine	15-28	monoamine oxidase A	Homo sapiens	0-5
14678242-17	2003	Lipoxygenase products may blunt noradrenaline-induced vasoconstriction, but our observations may, instead, reflect LOX-independent effects of esculetin.	Norepinephrine	32-45	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	0-12
1659347-1	1991	Neuropeptide Y (NPY) is coreleased with noradrenaline (NA) from sympathetic nerve endings.	Norepinephrine	40-53	neuropeptide Y	Canis lupus familiaris	0-14
14514739-4	2003	Univariate analysis revealed that plasma NPY was directly related to plasma norepinephrine (r = 0.37, P &lt; 0.001) and epinephrine (r = 0.17, P = 0.005), exceeding the upper limit of the normal range in the majority of patients with end-stage renal disease (170 of 277, 61%).	Norepinephrine	76-90	neuropeptide Y	Homo sapiens	41-44
14514739-7	2003	Plasma NPY maintained its predictive power for CV events in statistical model including plasma norepinephrine.	Norepinephrine	95-109	neuropeptide Y	Homo sapiens	7-10
12771046-7	2003	In the kidney, the catechol-O-methyltransferase inhibitor quercetin and norepinephrine (10 micromol/L) reduced methylation of 2-hydroxyestradiol by approximately 90% and 41%, respectively.	Norepinephrine	72-86	catechol-O-methyltransferase	Rattus norvegicus	19-47
12818698-2	2003	In the current study, we examined the role of protein kinase A, protein kinase C and Ca(2+) entry through L-type Ca(2+) channels in naloxone-precipitated increase turnover of noradrenaline in the right and left ventricle.	Norepinephrine	175-188	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	46-62
12818698-6	2003	Taken together, these data might indicate that protein kinase A activity is necessary for the enhancement of noradrenaline turnover during morphine withdrawal and that an up-regulated Ca(2+) system might contribute to the increase of noradrenaline turnover.	Norepinephrine	109-122	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	47-63
12754374-4	2003	Acute administration of adrenaline or noradrenaline increased mPer1 but not mPer2 expression in the liver of mice in vivo and in hepatic slices in vitro.	Norepinephrine	38-51	period circadian clock 1	Mus musculus	62-67
12668587-4	2003	Renal norepinephrine spillover was correlated with plasma leptin (r=0.628, P&lt;0.01), but other measures of sympathoadrenal function did not.	Norepinephrine	6-20	leptin	Homo sapiens	58-64
12651915-3	2003	In endothelium-intact strips, the AT1R-blocker olmesartan (1 microM) and the ACE-inhibitor temocaprilat (1 microM) each enhanced the ACh (0.03 microM)-induced relaxation during the contraction induced by noradrenaline (NA, 10 microM).	Norepinephrine	204-217	angiotensin-converting enzyme	Oryctolagus cuniculus	77-80
1659347-1	1991	Neuropeptide Y (NPY) is coreleased with noradrenaline (NA) from sympathetic nerve endings.	Norepinephrine	40-53	neuropeptide Y	Canis lupus familiaris	16-19
1654268-0	1991	Alpha 2A- and alpha 2C-adrenoceptor subtypes are differentially down-regulated by norepinephrine.	Norepinephrine	82-96	adrenoceptor alpha 2A	Homo sapiens	0-35
1717871-1	1991	The purpose of this study was to determine whether norepinephrine (NE) mediated the reduction in the activity of tryptophan hydroxylase (TPH) in the hippocampus and other serotonergic changes, induced by a single or multiple administrations of methamphetamine.	Norepinephrine	51-65	tryptophan hydroxylase 1	Rattus norvegicus	113-135
1717871-1	1991	The purpose of this study was to determine whether norepinephrine (NE) mediated the reduction in the activity of tryptophan hydroxylase (TPH) in the hippocampus and other serotonergic changes, induced by a single or multiple administrations of methamphetamine.	Norepinephrine	51-65	tryptophan hydroxylase 1	Rattus norvegicus	137-140
2033506-1	1991	Previous studies have reported that maximally effective concentrations of the "mixed" alpha and beta adrenoceptor agonists, epinephrine and norepinephrine, cause greater amounts of mucin secretion than the "pure" beta adrenoceptor agonist, isoproterenol, and that this response requires extracellular calcium.	Norepinephrine	140-154	solute carrier family 13 member 2	Rattus norvegicus	181-186
12615050-1	2003	The beta-2-adrenergic receptor (beta(2)AR) is expressed by most lymphocyte populations and binds the sympathetic neurotransmitter norepinephrine (NE).	Norepinephrine	130-144	adrenergic receptor, beta 2	Mus musculus	4-30
12615050-1	2003	The beta-2-adrenergic receptor (beta(2)AR) is expressed by most lymphocyte populations and binds the sympathetic neurotransmitter norepinephrine (NE).	Norepinephrine	130-144	adrenergic receptor, beta 2	Mus musculus	32-41
12535931-11	2003	Taken together, the data indicate that GTP cyclohydrolase I plays a crucial role in regulating norepinephrine biosynthesis by a pathway the activity of which is triggered by lipopolysaccharide i.p.	Norepinephrine	95-109	GTP cyclohydrolase 1	Mus musculus	39-59
12444905-1	2002	Neuropeptide Y (NPY) is co-released with noradrenaline from sympathetic nerves, has a strong vasoconstrictive action, and causes an attenuation of parasympathetic action in animal experiments.	Norepinephrine	41-54	neuropeptide Y	Homo sapiens	0-14
12444905-1	2002	Neuropeptide Y (NPY) is co-released with noradrenaline from sympathetic nerves, has a strong vasoconstrictive action, and causes an attenuation of parasympathetic action in animal experiments.	Norepinephrine	41-54	neuropeptide Y	Homo sapiens	16-19
12502025-0	2002	Interleukin 1alpha alters hippocampal serotonin and norepinephrine release during open-field behavior in Sprague-Dawley animals: differences from the Fawn-Hooded animal model of depression.	Norepinephrine	52-66	interleukin 1 alpha	Homo sapiens	0-18
12242714-1	2002	There are three subtypes of alpha2 adrenoceptor, i.e., alpha2A, alpha2B, and alpha2C, mediating the specific effect of epinephrine and norepinephrine in various tissues by means of G protein-coupled signal transduction pathways.	Norepinephrine	135-149	adrenergic receptor, alpha 2b	Mus musculus	64-71
1882084-3	1991	The findings revealed that oxytocin caused the release of more norepinephrine (NE) from the denervated glands up to 24 h after treatment.	Norepinephrine	63-77	oxytocin/neurophysin I prepropeptide	Homo sapiens	27-35
2000991-0	1991	Adenosine deaminase and adenosine attenuate ventricular arrhythmias caused by norepinephrine.	Norepinephrine	78-92	adenosine deaminase	Canis lupus familiaris	0-19
2000991-3	1991	Ventricular tachycardia caused by 200 ng.kg-1.min-1 norepinephrine was reduced from 1.2 +/- 0.3 to 0.1 +/- 0.1 bouts/10 cardiac cycles (P less than 0.05) by adenosine deaminase.	Norepinephrine	52-66	adenosine deaminase	Canis lupus familiaris	157-176
2000991-6	1991	We conclude that both adenosine and adenosine deaminase significantly attenuate norepinephrine-induced ventricular arrhythmias.	Norepinephrine	80-94	adenosine deaminase	Canis lupus familiaris	36-55
1908674-2	1991	A single injection of norepinephrine (2.5 micrograms/kg to 2.5 mg/kg) led to transient increases in the levels of both c-fos and c-myc mRNA.	Norepinephrine	22-36	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	119-124
1705122-0	1991	Endothelin-1 stimulation of noradrenaline and adrenaline release from adrenal chromaffin cells.	Norepinephrine	28-41	endothelin 1	Bos taurus	0-12
12050158-0	2002	Norepinephrine increases I kappa B alpha expression in astrocytes.	Norepinephrine	0-14	NFKB inhibitor alpha	Rattus norvegicus	25-40
12193117-10	2002	We conclude from our results that dogs receiving the selective ET-A inhibitor ABT-627 seem to show a different hormonal response after haemorrhage compared with controls, displaying considerably higher noradrenaline concentrations.	Norepinephrine	202-215	endothelin receptor type A	Canis lupus familiaris	63-67
12074941-4	2002	The depressor response to human urotensin II (3 nmol/kg) was attenuated by approximately 50% in rats with MAP elevated through pretreatment with N(G)-nitro-L-arginine methyl ester (inhibitor of NO synthase), relative to that in rats with MAP elevated to a similar level through a continuous infusion of noradrenaline.	Norepinephrine	303-316	urotensin 2	Homo sapiens	32-44
12106798-3	2002	The possible actions of neuropeptide Y, that is co-localized and released with noradrenaline, as a sympathetic co-transmitter has attracted much attention during the last decade.	Norepinephrine	79-92	neuropeptide Y	Homo sapiens	24-38
12059116-1	2002	Adrenergic receptors mediate the central and peripheral actions of norepinephrine and epinephrine and are pharmacologically divided into three major types, alpha-1, alpha-2, and beta.	Norepinephrine	67-81	adrenoceptor alpha 1D	Homo sapiens	156-163
1705122-1	1991	Endothelin-1 (ET-1) stimulated release of both noradrenaline and adrenaline from cultured bovine adrenal chromaffin cells; stimulated release was small compared to that elicited by 50 mM potassium.	Norepinephrine	47-60	endothelin 1	Bos taurus	0-12
11857576-2	2002	The DBH gene, the locus that encodes the enzyme dopamine-beta-hydroxylase (DbetaH), seems to be an important candidate gene for association studies, since DbetaH catalyzes the conversion of dopamine to norepinephrine.	Norepinephrine	202-216	dopamine beta-hydroxylase	Homo sapiens	4-7
11857576-2	2002	The DBH gene, the locus that encodes the enzyme dopamine-beta-hydroxylase (DbetaH), seems to be an important candidate gene for association studies, since DbetaH catalyzes the conversion of dopamine to norepinephrine.	Norepinephrine	202-216	dopamine beta-hydroxylase	Homo sapiens	48-73
1705122-1	1991	Endothelin-1 (ET-1) stimulated release of both noradrenaline and adrenaline from cultured bovine adrenal chromaffin cells; stimulated release was small compared to that elicited by 50 mM potassium.	Norepinephrine	47-60	endothelin 1	Bos taurus	14-18
1705122-7	1991	These results show that ET-1 may stimulate both noradrenaline and adrenaline containing chromaffin cells by a mechanism which, while partially dependent on dihydropyridine sensitive calcium channels, is distinct from the calcium channel agonist or membrane depolarization.	Norepinephrine	48-61	endothelin 1	Bos taurus	24-28
2085713-9	1990	The effect of a low dose of PAF (0.1 microgram kg-1) on the vascular permeability of the trachea and bronchi (but not of the parenchyma) was potentiated by compound U-44069 (5.0 micrograms kg-1) or noradrenaline (400 ng kg-1) whereas the effect of a high dose of PAF (5.0 micrograms kg-1) was not affected.	Norepinephrine	198-211	PCNA clamp associated factor	Rattus norvegicus	28-31
11857564-1	2002	Norepinephrine (NE), a key neurotransmitter of the central and peripheral nervous systems, is synthesized by dopamine beta-hydroxylase (DBH) that catalyzes oxidation of dopamine (DA) to NE.	Norepinephrine	0-14	dopamine beta-hydroxylase	Homo sapiens	109-134
11857564-1	2002	Norepinephrine (NE), a key neurotransmitter of the central and peripheral nervous systems, is synthesized by dopamine beta-hydroxylase (DBH) that catalyzes oxidation of dopamine (DA) to NE.	Norepinephrine	0-14	dopamine beta-hydroxylase	Homo sapiens	136-139
11904129-1	2002	BACKGROUND: Plasma activity of dopamine beta-hydroxylase (DbetaH), the enzyme that converts dopamine to norepinephrine, is reportedly lower in patients with unipolar major depression with psychotic features (UDPF) than in those with nonpsychotic unipolar major depression (UD).	Norepinephrine	104-118	dopamine beta-hydroxylase	Homo sapiens	31-56
11904129-1	2002	BACKGROUND: Plasma activity of dopamine beta-hydroxylase (DbetaH), the enzyme that converts dopamine to norepinephrine, is reportedly lower in patients with unipolar major depression with psychotic features (UDPF) than in those with nonpsychotic unipolar major depression (UD).	Norepinephrine	104-118	dopamine beta-hydroxylase	Homo sapiens	58-64
11904129-13	2002	In this regard, we hypothesize that abnormal regulation of hypothalamic-pituitary-adrenal function in UDPF lowers expression of DbetaH protein, which could in turn alter the ratio of dopamine and norepinephrine in noradrenergic neurons, thereby promoting development of psychotic symptoms.	Norepinephrine	196-210	dopamine beta-hydroxylase	Homo sapiens	128-134
11904130-2	2002	Dopamine beta-hydroxylase (DbetaH) catalyses the key step in biosynthesis of the neurotransmitter noradrenaline from dopamine, and low DbetaH activity is a possible risk factor for developing psychotic depression.	Norepinephrine	98-111	dopamine beta-hydroxylase	Homo sapiens	0-25
2253318-2	1990	PAF infusion (50 ng/kg/min for 60 min) resulted in a sustained hypotension, with tachycardia and elevated plasma norepinephrine (NE; 1.8-fold increase), epinephrine (E; 6.7-fold increase), and dopamine (DA; 1.0-fold increase) at 30 min after beginning infusion.	Norepinephrine	113-127	PCNA clamp associated factor	Rattus norvegicus	0-3
1981788-5	1990	Compared to naive PC12 cells, K-ras infected PC12 cells had (a) higher activities of acetylcholinesterase and choline acetyltransferase, two enzymes involved in acetylcholine metabolism; (b) enhanced activity of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis; (c) a higher, evoked norepinephrine release; and (d) similar levels of sodium-dependent uptake of both choline and norepinephrine.	Norepinephrine	311-325	KRAS proto-oncogene, GTPase	Rattus norvegicus	30-35
1981788-5	1990	Compared to naive PC12 cells, K-ras infected PC12 cells had (a) higher activities of acetylcholinesterase and choline acetyltransferase, two enzymes involved in acetylcholine metabolism; (b) enhanced activity of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis; (c) a higher, evoked norepinephrine release; and (d) similar levels of sodium-dependent uptake of both choline and norepinephrine.	Norepinephrine	405-419	KRAS proto-oncogene, GTPase	Rattus norvegicus	30-35
1983139-8	1990	A significant relationship between the concentrations of somatostatin and noradrenaline in cord blood was found, (r = 0.7, n = 11, P less than 0.01).	Norepinephrine	74-87	somatostatin	Homo sapiens	57-69
11867178-5	2002	NPY levels correlated inversely with renal plasma flow and glomerular filtration rate and directly with norepinephrine.	Norepinephrine	104-118	neuropeptide Y	Homo sapiens	0-3
11882635-1	2002	We have reported that norepinephrine (NE) and angiotensin II (Ang II) increase CaM kinase II activity, which, in turn, activates cytosolic phospholipase A(2) (PLA(2)) and releases arachidonic acid.	Norepinephrine	22-36	phospholipase A2 group IB	Rattus norvegicus	139-157
11882635-1	2002	We have reported that norepinephrine (NE) and angiotensin II (Ang II) increase CaM kinase II activity, which, in turn, activates cytosolic phospholipase A(2) (PLA(2)) and releases arachidonic acid.	Norepinephrine	22-36	phospholipase A2 group IB	Rattus norvegicus	159-165
11854096-2	2002	In this study, the accumulation of AA-NAT mRNA induced by norepinephrine (NE) and peptides of the secretin superfamily (pituitary adenylate cyclase activating polypeptide (PACAP), vasoactive intestinal peptide (VIP), growth hormone releasing factor (GRF), secretin) was investigated by a new quantitative reverse transcription-PCR (RT-PCR) assay.	Norepinephrine	58-72	aralkylamine N-acetyltransferase	Rattus norvegicus	35-41
11805223-9	2002	Norepinephrine release promoted by ATP was also potentiated by the nucleotidase inhibitor 6-N,N-diethyl-beta-gamma-dibromomethylene-D-adenosine-5"-triphosphate (ARL67156) (30 microM) and blocked by a recombinant, soluble form of human E-NTPDase1 (solCD39).	Norepinephrine	0-14	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	235-245
1983139-15	1990	We conclude that the somatostatin level, but not the gastrin level is influenced by the degree of fetal stress during labour, as evidenced by the relationship with noradrenaline.	Norepinephrine	164-177	somatostatin	Homo sapiens	21-33
1697381-7	1990	Inosine in combination with ADA antagonized the noradrenaline-induced positive inotropic effect and the increase in cardiac output.	Norepinephrine	48-61	adenosine deaminase	Rattus norvegicus	28-31
11903811-0	2002	Noradrenaline and dopamine regulation of prolactin secretion in sheep: role in prolactin homeostasis but not photoperiodism.	Norepinephrine	0-13	prolactin	Ovis aries	79-88
11903811-1	2002	The role of noradrenaline (NA) and dopamine (DA) in the hypothalamic control of prolactin (PRL) secretion was investigated in hypothalamic intact (control) and hypothalamo-pituitary disconnected (HPD) Soay rams.	Norepinephrine	12-25	prolactin	Ovis aries	80-89
12448081-8	2002	The co-localization of GAL and dopamine beta-hydroxylase (D beta H--a key enzyme of the noradrenaline synthesis pathway) in perivascular nerve fibers could lead to considerable vasospasms in the pancreas, resulting in deeper hypoxia of the organ.	Norepinephrine	88-101	dopamine beta-hydroxylase	Homo sapiens	31-56
1697381-9	1990	bolus injection of noradrenaline in rats pretreated with inosine and ADA did not increase blood pressure and total peripheral resistance.	Norepinephrine	19-32	adenosine deaminase	Rattus norvegicus	69-72
1698509-1	1990	The neuropeptide galanin (GAL) has been found to elicit feeding after injection into the paraventricular hypothalamic nucleus (PVN), where it coexists with norepinephrine (NE), a neurotransmitter believed to be important in the control of natural feeding behavior.	Norepinephrine	156-170	galanin and GMAP prepropeptide	Homo sapiens	17-24
11782784-1	2001	Amylin (10(-10)M) induced relaxation of norepinephrine-precontracted rat aortic rings by more than 50%.	Norepinephrine	40-54	islet amyloid polypeptide	Rattus norvegicus	0-6
11520626-11	2001	Knocking out the dopamine beta-hydroxylase gene results in fetal death, suggesting that noradrenaline is essential for survival.	Norepinephrine	88-101	dopamine beta-hydroxylase	Homo sapiens	17-42
11571937-2	2001	The brain"s ability to mobilize this so-called stress response is paralleled by activation of corticotropin-releasing hormone (CRH) in several nuclei, including the hypothalamus, amygdala and locus ceruleus, and stimulation of the locus ceruleus norepinephrine (LC/NE) system in the brain stem.	Norepinephrine	246-260	corticotropin releasing hormone	Homo sapiens	94-125
11571937-2	2001	The brain"s ability to mobilize this so-called stress response is paralleled by activation of corticotropin-releasing hormone (CRH) in several nuclei, including the hypothalamus, amygdala and locus ceruleus, and stimulation of the locus ceruleus norepinephrine (LC/NE) system in the brain stem.	Norepinephrine	246-260	corticotropin releasing hormone	Homo sapiens	127-130
11677796-2	2001	The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3).	Norepinephrine	45-58	adrenergic receptor, alpha 2b	Mus musculus	246-254
11677796-2	2001	The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3).	Norepinephrine	45-58	hemoglobin, beta adult major chain	Mus musculus	292-298
11481155-0	2001	CSF norepinephrine concentrations in posttraumatic stress disorder.	Norepinephrine	4-18	colony stimulating factor 2	Homo sapiens	0-3
1698509-1	1990	The neuropeptide galanin (GAL) has been found to elicit feeding after injection into the paraventricular hypothalamic nucleus (PVN), where it coexists with norepinephrine (NE), a neurotransmitter believed to be important in the control of natural feeding behavior.	Norepinephrine	156-170	galanin and GMAP prepropeptide	Homo sapiens	26-29
2328760-4	1990	In aorta, ISF-2405 inhibited the increase in [Ca2+]cyt and muscle tension caused by norepinephrine.	Norepinephrine	84-98	carbonic anhydrase 2	Canis lupus familiaris	46-49
2328760-5	1990	A Ca2+ channel blocker, verapamil, inhibited the norepinephrine-stimulated increase in [Ca2+]cyt more potently than it inhibited the increase in muscle tension, and ISF-2405 inhibited the verapamil-resistant part of the contraction.	Norepinephrine	49-63	carbonic anhydrase 2	Canis lupus familiaris	2-5
2328760-5	1990	A Ca2+ channel blocker, verapamil, inhibited the norepinephrine-stimulated increase in [Ca2+]cyt more potently than it inhibited the increase in muscle tension, and ISF-2405 inhibited the verapamil-resistant part of the contraction.	Norepinephrine	49-63	carbonic anhydrase 2	Canis lupus familiaris	88-91
2328760-6	1990	In Ca2(+)-free solution, norepinephrine induced transient increases in [Ca2+]cyt and muscle tension.	Norepinephrine	25-39	carbonic anhydrase 2	Canis lupus familiaris	3-6
2328760-6	1990	In Ca2(+)-free solution, norepinephrine induced transient increases in [Ca2+]cyt and muscle tension.	Norepinephrine	25-39	carbonic anhydrase 2	Canis lupus familiaris	72-75
1969352-1	1990	Phosphorylation of the neuron-specific substrate of protein kinase C (PKC), B-50 (GAP-43), was studied parallel with noradrenaline release in rat brain synaptosomes.	Norepinephrine	117-130	protein kinase C, gamma	Rattus norvegicus	52-68
1969352-4	1990	To investigate the involvement of PKC-mediated B-50 phosphorylation in noradrenaline release, we applied a variety of kinase inhibitors.	Norepinephrine	71-84	protein kinase C, gamma	Rattus norvegicus	34-37
1969403-9	1990	The percentage of cells in which PCNA could be detected was higher in the norepinephrine and norepinephrine plus propranolol groups.	Norepinephrine	74-88	proliferating cell nuclear antigen	Rattus norvegicus	33-37
1969403-9	1990	The percentage of cells in which PCNA could be detected was higher in the norepinephrine and norepinephrine plus propranolol groups.	Norepinephrine	93-107	proliferating cell nuclear antigen	Rattus norvegicus	33-37
2252308-17	1990	In the rat saphenous vein, 5-HT1B receptors mediate inhibition of noradrenaline release.	Norepinephrine	66-79	5-hydroxytryptamine receptor 1B	Rattus norvegicus	27-33
11481155-2	2001	The goal of this study was to determine serial CSF norepinephrine levels in patients with PTSD.	Norepinephrine	51-65	colony stimulating factor 2	Homo sapiens	47-50
11481155-4	2001	Thus the authors were able to determine hourly CSF norepinephrine concentrations under baseline (unstressed) conditions.	Norepinephrine	51-65	colony stimulating factor 2	Homo sapiens	47-50
11481155-6	2001	RESULTS: CSF norepinephrine concentrations were significantly higher in the men with PTSD than in the healthy men.	Norepinephrine	13-27	colony stimulating factor 2	Homo sapiens	9-12
11481155-7	2001	Moreover, CSF norepinephrine levels strongly and positively correlated with the severity of PTSD symptoms.	Norepinephrine	14-28	colony stimulating factor 2	Homo sapiens	10-13
11470013-10	2001	At the postsynaptic level, all currently used antihypertensive drugs have been found to attenuate alpha1-adrenergic functions either by interfering directly with intracellular mechanisms underlying alpha1-adrenergic functions or indirectly by decreasing the release of norepinephrine from peripheral sympathetic nerves.	Norepinephrine	269-283	adrenoceptor alpha 1D	Homo sapiens	98-104
2369799-0	1990	Effects of a protein kinase C inhibitor (H-7) on norepinephrine release from vascular adrenergic neurons in spontaneously hypertensive rats.	Norepinephrine	49-63	solute carrier family 9 member A2	Rattus norvegicus	41-44
2177712-0	1990	Role of adenylate cyclase in modulatory effect of neuropeptide Y on [3H]noradrenaline release in guinea-pig vas deferens.	Norepinephrine	72-85	pro-neuropeptide Y	Cavia porcellus	50-64
11394305-0	2001	A method for the measurement of catechol-O-methyltransferase activity using norepinephrine, an endogenous substrate.	Norepinephrine	76-90	catechol-O-methyltransferase	Rattus norvegicus	32-60
2182573-6	1990	Both norepinephrine and epinephrine containing cells of the adrenal medulla exhibited a strong reaction for PLI.	Norepinephrine	5-19	serpin family F member 2	Homo sapiens	108-111
1981283-14	1990	In addition, the time course of the norepinephrine-mediated slow EPSPs and IPSPs in SPN is consistent with a gain-setting function.	Norepinephrine	36-50	DEAF1 transcription factor	Homo sapiens	84-87
34957858-12	2022	These responses may be mediated by hypoxemia induced endocrine responses including increased norepinephrine and cortisol, which inhibit pancreatic insulin secretion resulting in lower insulin concentrations and decreased stimulation of glucose utilization.	Norepinephrine	93-107	LOC105613195	Ovis aries	184-191
11394305-1	2001	We propose a highly sensitive method for the measurement of catechol-O-methyltransferase (COMT) activity with norepinephrine (NE), an endogenous native substrate.	Norepinephrine	110-124	catechol-O-methyltransferase	Rattus norvegicus	60-88
11394305-1	2001	We propose a highly sensitive method for the measurement of catechol-O-methyltransferase (COMT) activity with norepinephrine (NE), an endogenous native substrate.	Norepinephrine	110-124	catechol-O-methyltransferase	Rattus norvegicus	90-94
11316770-2	2001	Stress activates A1/A2 noradrenergic neurons, and then noradrenaline (NA) stimulates ACTH secretion through hypothalamic CRH.	Norepinephrine	55-68	corticotropin releasing hormone	Homo sapiens	121-124
34958827-9	2022	Norepinephrine (NE), PMA and m-3M3FBS were used to activate alpha-1 adrenergic signaling.	Norepinephrine	0-14	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	60-67
11264228-6	2001	Inhibition of noradrenaline-induced contractions by DXR was attenuated by superoxide dismutase, and alpha(1A)-adrenoceptor protein expression recovered.	Norepinephrine	14-27	alpha-1A adrenergic receptor	Oryctolagus cuniculus	100-122
11264228-13	2001	These results suggest that 0.3 microM DXR selectively down-regulates the alpha(1A)-adrenoceptor protein expression, resulting in a decrease in the noradrenaline-induced contraction.	Norepinephrine	147-160	alpha-1A adrenergic receptor	Oryctolagus cuniculus	73-95
11239919-0	2001	Inhibition by L-3,4-dihydroxyphenylalanine of hippocampal CA1 neurons with facilitation of noradrenaline and gamma-aminobutyric acid release.	Norepinephrine	91-104	carbonic anhydrase 1	Rattus norvegicus	58-61
11239021-0	2001	Erythropoietin modulates angiotensin II- or noradrenaline-induced Ca(2+) mobilization in cultured rat vascular smooth-muscle cells.	Norepinephrine	44-57	erythropoietin	Rattus norvegicus	0-14
34968668-8	2022	The TGF-alpha siRNA-treated HF rats also exhibited lower plasma norepinephrine levels and improved peripheral manifestations of HF.	Norepinephrine	64-78	transforming growth factor alpha	Rattus norvegicus	4-13
34880955-11	2021	These results suggest that elevation of solitary nitric oxide signaling derived from nNOS mediates stress-precipitated anxiety and norepinephrine release in the BNST during protracted EtOHW.	Norepinephrine	131-145	nitric oxide synthase 1	Rattus norvegicus	85-89
34425806-5	2021	The activity of beta-ARs was modulated by an agonist, norepinephrine (NE), and antagonists, including propranolol, atenolol, nebivolol, and nadolol.	Norepinephrine	54-68	alanyl-tRNA synthetase 1	Homo sapiens	16-24
35568869-7	2022	GSK3 inactivation also prevents B2AR agonist norepinephrine or MOR agonist DAMGO from affecting MDA-MB-231 and MDA-MB-468 cell proliferation.	Norepinephrine	45-59	adrenoceptor beta 2	Homo sapiens	32-36
35351968-8	2022	EBI2 activation in brown adipocytes significantly reduces norepinephrine-induced cAMP production, whereas pharmacological inhibition or genetic ablation of EBI2 results in an increased response.	Norepinephrine	58-72	G protein-coupled receptor 183	Mus musculus	0-4
35351968-8	2022	EBI2 activation in brown adipocytes significantly reduces norepinephrine-induced cAMP production, whereas pharmacological inhibition or genetic ablation of EBI2 results in an increased response.	Norepinephrine	58-72	G protein-coupled receptor 183	Mus musculus	156-160
35351968-9	2022	Importantly, EBI2 significantly inhibits norepinephrine-induced activation of human brown adipocytes.	Norepinephrine	41-55	G protein-coupled receptor 183	Homo sapiens	13-17
34772856-8	2022	Furthermore, urinary excretion of adrenaline and noradrenaline by fld mice was significantly higher compared with that of control mice.	Norepinephrine	49-62	lipin 1	Mus musculus	66-69
11285376-10	2001	The CSF metabolite of norepinephrine (MHPG) was lower (P:=0.003) in PFS patients (8.33+/-0.33 ng/ml) than in matched controls (9.89+/-0.31 ng/ml) and 5-HIAA was lower (P=0.042) in PFS female patients (22.34+/-1.78 ng/ml) than in matched controls (25.75+/-1.75 ng/ml).	Norepinephrine	22-36	colony stimulating factor 2	Homo sapiens	4-7
35051185-5	2022	During spontaneous atrial contraction, PKD2L1del-Tg atria showed enhanced sensitivity to isoproterenol, norepinephrine, and epinephrine.	Norepinephrine	104-118	polycystic kidney disease 2-like 1	Mus musculus	39-45
11170900-1	2001	Dopamine-beta-hydroxylase (D beta H) catalyzes the conversion of dopamine to norepinephrine and is released from sympathetic neurons into the circulation.	Norepinephrine	77-91	dopamine beta-hydroxylase	Homo sapiens	0-25
35054851-2	2022	This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA.	Norepinephrine	72-86	adrenoceptor beta 2	Homo sapiens	44-64
11154836-2	2001	These cells express the mRNA encoding estrogen receptor alpha (ERalpha) and respond to physiological concentrations of 17beta-estradiol (E2) by reducing the accumulation of cyclic adenosine monophosphate induced by norepinephrine, but not that induced by direct activation of adenylate cyclase.	Norepinephrine	215-229	estrogen receptor 1 (alpha)	Mus musculus	38-61
11154836-2	2001	These cells express the mRNA encoding estrogen receptor alpha (ERalpha) and respond to physiological concentrations of 17beta-estradiol (E2) by reducing the accumulation of cyclic adenosine monophosphate induced by norepinephrine, but not that induced by direct activation of adenylate cyclase.	Norepinephrine	215-229	estrogen receptor 1 (alpha)	Mus musculus	63-70
35054851-2	2022	This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA.	Norepinephrine	72-86	interleukin 17A	Homo sapiens	110-124
35054851-2	2022	This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA.	Norepinephrine	72-86	interleukin 17A	Homo sapiens	126-131
35054851-2	2022	This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA.	Norepinephrine	72-86	adrenoceptor beta 2	Homo sapiens	374-394
12369708-6	2001	BDNF enhanced norepinephrine turnover and increased uncoupling protein-1 mRNA expression in the interscapular brown adipose tissue.	Norepinephrine	14-28	brain derived neurotrophic factor	Mus musculus	0-4
35054851-2	2022	This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA.	Norepinephrine	352-366	adrenoceptor beta 2	Homo sapiens	44-64
35054851-2	2022	This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA.	Norepinephrine	352-366	interleukin 17A	Homo sapiens	110-124
35054851-2	2022	This study aimed to clarify the role of the beta2-adrenoreceptor in the norepinephrine-mediated modulation of interleukin-17 (IL-17) and interferon-gamma (IFN-gamma) production, which play a critical pathogenetic role in MS. CD4+ T cells obtained from twenty-five relapsing-remitting MS patients and sixteen healthy subjects were cultured ex vivo with norepinephrine and/or beta2-adrenoreceptor antagonist or agonist, followed by a cytokine production analysis using ELISA.	Norepinephrine	352-366	interleukin 17A	Homo sapiens	126-131
10921912-3	2000	The activatory effects of norepinephrine and retinoic acid (RA) on rodent ucp1 gene transcription have been well characterized.	Norepinephrine	26-40	uncoupling protein 1	Homo sapiens	74-78
35054851-3	2022	Norepinephrine suppressed IL-17 and IFN-gamma production by the anti-CD3/anti-CD28-microbead-stimulated CD4+ T cells in both groups.	Norepinephrine	0-14	interleukin 17A	Homo sapiens	26-31
35054851-4	2022	Blockade of the beta2-adrenoreceptor with the specific antagonist ICI 118.551 enhanced norepinephrine-mediated IL-17 suppression but decreased its inhibitory effect on IFN-gamma production in MS patients.	Norepinephrine	87-101	interleukin 17A	Homo sapiens	111-116
35054851-8	2022	These data illustrate the inhibitory effect of norepinephrine on IL-17 and IFN-gamma production by CD4+ T cells in MS.	Norepinephrine	47-61	interleukin 17A	Homo sapiens	65-70
35054851-9	2022	The inhibitory effect of norepinephrine on IFN-gamma production by CD4+ T cells in MS could be mediated via beta2-adrenoreceptor activation.	Norepinephrine	25-39	adrenoceptor beta 2	Homo sapiens	108-128
2615846-0	1989	Neuropeptide Y differentiates between exocytotic and nonexocytotic noradrenaline release in guinea-pig heart.	Norepinephrine	67-80	pro-neuropeptide Y	Cavia porcellus	0-14
11033344-5	2000	Naloxone and opioid agents, such as morphine, beta-endorphin and [Met(5)]-enkephalin, significantly enhanced and attenuated the stress-induced increase in noradrenaline release in these regions and the stress-induced emotional change, respectively.	Norepinephrine	155-168	proenkephalin	Rattus norvegicus	74-84
2615846-10	1989	The results indicate that NPY is co-released with noradrenaline only during calcium-dependent exocytosis.	Norepinephrine	50-63	pro-neuropeptide Y	Cavia porcellus	26-29
11081224-2	2000	Results of the biochemical analysis of the MAO A activity with serotonin or noradrenaline as substrates revealed a seasonal dependence of the substrate specific changes of this enzyme activity in hibernating animals.	Norepinephrine	76-89	monoamine oxidase A	Homo sapiens	43-48
2555449-0	1989	A molecular modelling study of the interaction of noradrenaline with the beta 2-adrenergic receptor.	Norepinephrine	50-63	adrenoceptor beta 2	Homo sapiens	73-99
10961962-2	2000	Neuropeptide Y (NPY), which is costored and released with norepinephrine (NE) during sympathetic activity, is a potent vasoconstrictor with a relatively long half-life.	Norepinephrine	58-72	neuropeptide Y	Homo sapiens	0-14
10961962-2	2000	Neuropeptide Y (NPY), which is costored and released with norepinephrine (NE) during sympathetic activity, is a potent vasoconstrictor with a relatively long half-life.	Norepinephrine	58-72	neuropeptide Y	Homo sapiens	16-19
2752979-11	1989	In isolated helical strips of rat aorta, PTHrp and PTH relaxed norepinephrine-contracted tissues in a concentration-dependent fashion.	Norepinephrine	63-77	parathyroid hormone-like hormone	Rattus norvegicus	41-46
2547929-3	1989	Synthetic rat ANF (99-126) inhibited K+-induced norepinephrine and dopamine release, as measured by high-performance liquid chromatography, in a concentration-dependent manner over the concentration range of 10(-11) to 10(-8) M. ANF stimulated intracellular cGMP accumulation, as measured by specific radioimmunoassay, in a concentration-dependent manner over the same concentration range.	Norepinephrine	48-62	natriuretic peptide A	Rattus norvegicus	14-17
2571509-1	1989	The effect of prolonged treatment with antidepressant drugs on the phenylephrine- and norepinephrine (NE)-evoked reaction in hippocampal slices was examined by extracellular recording of the spontaneous activity of CA1 layer neurons.	Norepinephrine	86-100	carbonic anhydrase 1	Homo sapiens	215-218
2763865-3	1989	Norepinephrine levels were elevated in the dorsal amygdala of rats injected with 10 micrograms of CCK as well as in the septum of rats injected with 1 and 10 micrograms of CCK.	Norepinephrine	0-14	cholecystokinin	Rattus norvegicus	98-101
2763865-3	1989	Norepinephrine levels were elevated in the dorsal amygdala of rats injected with 10 micrograms of CCK as well as in the septum of rats injected with 1 and 10 micrograms of CCK.	Norepinephrine	0-14	cholecystokinin	Rattus norvegicus	172-175
2544113-6	1989	Norepinephrine-precontracted vascular strips from ADR rats were more sensitive to ANF (ED50: 1.7 x 10(-8) M) than those from sham-operated animals (ED50: 1.5 x 10(-7) M).	Norepinephrine	0-14	natriuretic peptide A	Rattus norvegicus	82-85
2657281-4	1989	ZAC reduces acid and peptic secretion, increases mucus secretion, protects mucosa from disruption by aspirin and reverses the reduction of blood flow caused by noradrenaline.	Norepinephrine	160-173	PLAG1 like zinc finger 1	Homo sapiens	0-3
2566928-1	1989	The relationship between noradrenaline and neuropeptide Y (NPY) release was investigated in the in situ perfused guinea pig heart with intact sympathetic innervation.	Norepinephrine	25-38	pro-neuropeptide Y	Cavia porcellus	59-62
2566928-4	1989	When two subsequent stimulations (12 Hz; each for 1 min) were performed in the same heart, addition of noradrenaline (10 microM) 5 min prior to the second stimulation reduced NPY overflow by 43 +/- 10%.	Norepinephrine	103-116	pro-neuropeptide Y	Cavia porcellus	175-178
10952676-2	2000	Human U-II was a potent vasoconstrictor of endothelium-intact isolated rat thoracic aorta (EC(50)=3.5+/-1.1 nM, R(max)=103+/-10% of control contraction induced by 60 mM KCl and 1 microM noradrenaline).	Norepinephrine	186-199	urotensin 2	Homo sapiens	6-10
2566928-7	1989	Exogenous NPY (100 nM) attenuated the stimulated overflow of noradrenaline by 30 +/- 6%.	Norepinephrine	61-74	pro-neuropeptide Y	Cavia porcellus	10-13
2789414-8	1989	These data suggest that the increased responsiveness to L-5-HTP caused by T3 involves an indirect (norepinephrine-mediated) rather than a direct effect on serotonergic processes.	Norepinephrine	99-113	kinocilin	Mus musculus	56-59
10887204-1	2000	Dopamine-beta-hydroxylase (DbetaH) is a copper-containing enzyme that uses molecular oxygen and ascorbate to catalyze the addition of a hydroxyl group on the beta-carbon of dopamine to form norepinephrine.	Norepinephrine	190-204	dopamine beta-hydroxylase	Homo sapiens	0-25
10887204-1	2000	Dopamine-beta-hydroxylase (DbetaH) is a copper-containing enzyme that uses molecular oxygen and ascorbate to catalyze the addition of a hydroxyl group on the beta-carbon of dopamine to form norepinephrine.	Norepinephrine	190-204	dopamine beta-hydroxylase	Homo sapiens	27-33
2905622-3	1988	The present electrophysiological study was undertaken to characterize the adrenoceptor mediating the suppressant effect of microiontophoretically applied norepinephrine (NE) on CA1 and CA3 dorsal hippocampus pyramidal neurons of the rat.	Norepinephrine	154-168	carbonic anhydrase 3	Rattus norvegicus	185-188
2467974-3	1988	Stimulation-evoked noradrenaline release and pressor responses were inhibited by substance P and neurotensin.	Norepinephrine	19-32	neurotensin	Rattus norvegicus	97-108
10826917-8	2000	Other MPO systems inactivating LADH were (a) MPO/H2O2/chlorpromazine; (b) MPO/H2O2/monophenolic systems, including L-tyrosine, serotonin and acetaminophen and (c) MPO/H2O2/di- and polyphenolic systems, including norepinephrine, catechol, nordihydroguaiaretic acid, caffeic acid, quercetin and catechin.	Norepinephrine	212-226	myeloperoxidase	Sus scrofa	6-9
2467974-6	1988	These results showed that substance P and neurotensin could affect the presynaptic site of the blood vessels and cause a decrease in electrically stimulated noradrenaline release from the vascular adrenergic neurons.	Norepinephrine	157-170	neurotensin	Rattus norvegicus	42-53
10998536-2	2000	Nociceptin inhibits the electrically or K(+)-evoked noradrenaline, dopamine, serotonin, and glutamate release in brain slices from guinea-pig, rat, and mouse.	Norepinephrine	52-65	prepronociceptin	Rattus norvegicus	0-10
3209809-3	1988	Low concentrations of NPY (10(-8)-3 X 10(-7) mol.l-1) were more potent than equimolar concentrations of noradrenaline (NA).	Norepinephrine	104-117	pro-neuropeptide Y	Cavia porcellus	22-25
3401255-6	1988	Adenosine deaminase (0.5 U/ml) increased basal as well as theophylline- and norepinephrine-induced lipolysis.	Norepinephrine	76-90	adenosine deaminase	Rattus norvegicus	0-19
10981165-3	2000	Intravenous leptin increases norepinephrine turnover and sympathetic nerve activity to thermogenic brown adipose tissue.	Norepinephrine	29-43	leptin	Homo sapiens	12-18
2841837-6	1988	These results led to the following conclusions: Dopexamine hydrochloride stimulates the heart by 2 mechanisms--(1) baroreceptor-mediated release of norepinephrine resulting from hypotension produced by beta 2 adrenoceptor and DA1 dopamine receptor-mediated vasodilatation, and (2) potentiation of the released norepinephrine due to prevention of norepinephrine uptake by sympathetic nerves.	Norepinephrine	148-162	tropomyosin 2	Homo sapiens	226-229
10679505-8	2000	In all cases, the alpha(2)-AR-deficient groups tended to have higher norepinephrine levels than their wild-type counterparts.	Norepinephrine	69-83	adrenergic receptor, alpha 2b	Mus musculus	18-29
10679505-9	2000	Surprisingly, this difference was significant only in the alpha(2B)-AR-deficient mice, which, despite the elevated norepinephrine, were unable to raise their BP.	Norepinephrine	115-129	adrenergic receptor, alpha 2b	Mus musculus	58-70
10685879-7	2000	Procaine also inhibited uptake of norepinephrine (NE) and serotonin (5-HT) by the norepinephrine transporter (NET) or serotonin transporter (SERT) expressed in COS cells.	Norepinephrine	34-48	solute carrier family 6 member 2	Rattus norvegicus	82-108
10685879-7	2000	Procaine also inhibited uptake of norepinephrine (NE) and serotonin (5-HT) by the norepinephrine transporter (NET) or serotonin transporter (SERT) expressed in COS cells.	Norepinephrine	34-48	solute carrier family 6 member 2	Rattus norvegicus	110-113
10670458-5	2000	The promotion of memory consolidation by noradrenaline or isoprenaline at low doses was attributable to beta3-adrenoceptors and at medium doses to beta2-adrenoceptors.	Norepinephrine	41-54	basic helix-loop-helix family member e22	Gallus gallus	104-109
10647887-7	1999	The uVNTR genotype may be a common genetic determinant of significant individual differences in oxidizing capacity for critical MAO-A substrates, which include serotonin, norepinephrine, and tyramine.	Norepinephrine	171-185	monoamine oxidase A	Homo sapiens	128-133
10513987-3	1999	The stimulation of PLA2/lysophospholipase activity by noradrenaline (NA) was prevented either by the alpha1-adrenergic antagonist prazosin or arachidonyl trifluoromethyl ketone, a selective inhibitor of the 85-110 kDa, sn-2-arachidonyl-specific cytosolic PLA2.	Norepinephrine	54-67	phospholipase A2 group IB	Rattus norvegicus	19-23
10513987-3	1999	The stimulation of PLA2/lysophospholipase activity by noradrenaline (NA) was prevented either by the alpha1-adrenergic antagonist prazosin or arachidonyl trifluoromethyl ketone, a selective inhibitor of the 85-110 kDa, sn-2-arachidonyl-specific cytosolic PLA2.	Norepinephrine	54-67	phospholipase A2 group IB	Rattus norvegicus	255-259
2978748-2	1988	The influence of intra-arterial infusion of rat atrial natriuretic factor (ANF 8-33) and/or ouabain on the vascular responses to noradrenaline was investigated in the denervated and flow-controlled hindlimb preparations in pentobarbital anaesthetized dogs.	Norepinephrine	129-142	natriuretic peptide A	Rattus norvegicus	48-73
3289995-3	1988	In response to the elevated insulin level (263 +/- 39 microU/ml), plasma glucose level fell (41 +/- 3 mg/dl), and levels of the counterregulatory hormones glucagon, epinephrine, norepinephrine, and cortisol increased (91 +/- 29 to 271 +/- 55 pg/ml, 83 +/- 26 to 2356 +/- 632 pg/ml, 128 +/- 31 to 596 +/- 81 pg/ml, and 1.5 +/- 0.4 to 11.1 +/- 1.0 micrograms/dl, respectively; for all, P less than .05).	Norepinephrine	178-192	insulin	Canis lupus familiaris	28-35
3224030-5	1988	The release of norepinephrine from the postganglionic fiber of the superior cervical ganglia controls the production of melatonin in the pineal by regulating the activity of serotonin-N-acetyltransferase.	Norepinephrine	15-29	aralkylamine N-acetyltransferase	Homo sapiens	174-203
10598792-8	1999	Noradrenaline-induced [3H]IP1 accumulation was also inhibited by alpha1-antagonists.	Norepinephrine	0-13	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	26-29
10598792-10	1999	The accumulation of [3H]IP1 in response to 100 microM noradrenaline was not significantly affected by raising the extracellular Ca2+ concentration from 1.3 to 4 mM.	Norepinephrine	54-67	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	24-27
10598792-12	1999	Pretreatment with chloroethylclonidine (10 microM, 15 min) abolished noradrenaline-induced [3H]IP1 accumulation and Ca2+ mobilisation.	Norepinephrine	69-82	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	95-98
10499537-0	1999	Norepinephrine is required for leptin effects on gene expression in brown and white adipose tissue.	Norepinephrine	0-14	leptin	Mus musculus	31-37
10499537-11	1999	These studies establish that norepinephrine is required for leptin to regulate its own expression in WAT and UCP1 expression in BAT and indicate that these effects are likely mediated through the centrally expressed long form of the leptin receptor.	Norepinephrine	29-43	leptin	Mus musculus	60-66
10499537-11	1999	These studies establish that norepinephrine is required for leptin to regulate its own expression in WAT and UCP1 expression in BAT and indicate that these effects are likely mediated through the centrally expressed long form of the leptin receptor.	Norepinephrine	29-43	leptin receptor	Mus musculus	233-248
10629875-5	1999	And norepinephrine enhanced the effect of neuropeptide Y on lung vascular permeability.	Norepinephrine	4-18	neuropeptide Y	Homo sapiens	42-56
10409268-2	1999	In this study, primary brown adipocyte cultures were used to determine the role of beta-AR subtypes in mediating lipolysis and uncoupling protein-1 (UCP1) gene expression, elicited by the physiological neurohormone norepinephrine (NE).	Norepinephrine	215-229	uncoupling protein 1	Homo sapiens	127-153
3420006-2	1988	Results of these studies indicate that norepinephrine and carbachol evoke pharmacologically and temporally distinctive patterns of antral gastrin release.	Norepinephrine	39-53	gastrin	Rattus norvegicus	138-145
10443582-1	1999	Alpha1-adrenoceptors are one of three subfamilies of receptors (alpha1, alpha2, beta) mediating responses to adrenaline and noradrenaline.	Norepinephrine	124-137	adrenoceptor alpha 1D	Homo sapiens	0-6
10443582-1	1999	Alpha1-adrenoceptors are one of three subfamilies of receptors (alpha1, alpha2, beta) mediating responses to adrenaline and noradrenaline.	Norepinephrine	124-137	adrenoceptor alpha 1D	Homo sapiens	64-70
10037744-2	1999	NET is expressed only in neuronal tissues that synthesize and secrete norepinephrine and in most cases is co-expressed with the norepinephrine-synthetic enzyme dopamine beta-hydroxylase (DBH).	Norepinephrine	128-142	dopamine beta-hydroxylase	Homo sapiens	187-190
9928995-4	1999	It is concluded that sympathetic control of VEGF expression via noradrenaline acting on beta3-adrenoceptors plays a major role in developmental and adaptive angiogenesis, and defects in this contribute to the reduced thermogenic capacity of BAT in genetic obesity.	Norepinephrine	64-77	vascular endothelial growth factor A	Rattus norvegicus	44-48
3420006-3	1988	Dose-response experiments indicate that norepinephrine is approximately 10,000 times more potent on a molar basis than carbachol in stimulating antral gastrin release.	Norepinephrine	40-54	gastrin	Rattus norvegicus	151-158
10071761-3	1999	Recent studies have shown that the sympathetic nervous system, via norepinephrine (beta-adrenoceptors) and cAMP, as well as thyroid hormones and PPAR gamma ligands seem to be major regulators of UCP expression.	Norepinephrine	67-81	uncoupling protein 1	Homo sapiens	195-198
3420006-4	1988	Adrenergic (norepinephrine, isoproterenol) stimulation of antral gastrin release was prevented by propranolol, and cholinergic- (carbachol) mediated peptide release was blocked by both atropine and pirenzepine.	Norepinephrine	12-26	gastrin	Rattus norvegicus	65-72
3348422-0	1988	Adenosine deaminase attenuates norepinephrine-induced coronary functional hyperemia.	Norepinephrine	31-45	adenosine deaminase	Canis lupus familiaris	0-19
10467023-2	1999	Addition of beta-adrenoceptor agonists produced a concentration-dependent relaxation of noradrenaline-precontracted tissues, a rank order potency being isoproterenol (1) &gt; salbutamol (0.95) &gt; selective beta(3)-adrenoceptor agonists, CL 316243 (0.85), and BRL 37344 (0.	Norepinephrine	88-101	adrenoceptor beta 3	Canis lupus familiaris	208-228
10098976-3	1999	In this study, further characterization of p53LMAC01 cell line was investigated according to cell growth and differentiation, and especially focused into the changes of cell feature, actin filaments" formation, and changes of intracellular calcium concentrations to sympathetic nerve transmitter, norepinephrine.	Norepinephrine	297-311	transformation related protein 53, pseudogene	Mus musculus	43-46
10473248-3	1999	Norepinephrine axons, labeled with dopamine-beta-hydroxylase antibodies, formed a bed of fine varicose axons that co-distributed with the cholinergic cells.	Norepinephrine	0-14	dopamine beta-hydroxylase	Homo sapiens	35-60
2906499-1	1988	We investigated the direct pancreatic effects of noradrenaline in vivo on the secretion of insulin, glucagon, and somatostatin from the in situ pancreas in halothane-anaesthetized dogs.	Norepinephrine	49-62	insulin	Canis lupus familiaris	91-98
2906499-4	1988	The acute insulin response (AIR) to an intravenous injection of arginine (2.5 g), which was 4293 +/- 1260 microM min-1 under control conditions, was reduced to 1054 +/- 396 microU min-1 by noradrenaline (P less than 0.01).	Norepinephrine	189-202	insulin	Canis lupus familiaris	10-17
3171572-7	1988	In general, noradrenaline-containing neuronal cell body areas showed monoamine oxidase A, and 5-hydroxytryptamine-rich areas monoamine oxidase B.	Norepinephrine	12-25	monoamine oxidase B	Rattus norvegicus	125-144
3340619-1	1988	Carbon disulfide (CS2), tetraethyl lead (TEL), tetraethyl tin (TeET), dithiothreitol (DTT), and gossypol acetic acid (GAA) significantly decreased brain norepinephrine (NE) in rats.	Norepinephrine	153-167	calsyntenin 2	Rattus norvegicus	18-21
3340619-1	1988	Carbon disulfide (CS2), tetraethyl lead (TEL), tetraethyl tin (TeET), dithiothreitol (DTT), and gossypol acetic acid (GAA) significantly decreased brain norepinephrine (NE) in rats.	Norepinephrine	153-167	alpha glucosidase	Rattus norvegicus	118-121
2890079-6	1987	The intravenous injection of ovine GH (100 micrograms/kg) or equimolar amounts of SRIF (7.5 micrograms/kg) produced in the hepatic portal circulation a transient but statistically significant rise of serotonin and a concomitant reduction in the concentration of dopamine, norepinephrine, and epinephrine.	Norepinephrine	272-286	somatotropin	Canis lupus familiaris	35-37
2889453-3	1987	Conversely, EN, DA, and norepinephrine (NE) decreased the NGF content in growing cells.	Norepinephrine	24-38	nerve growth factor	Mus musculus	58-61
10189964-2	1999	In particular, hormones such as angiotensin II, endothelin 1, norepinephrine and prostaglandin F2 alpha which bind to and activate cardiomyocyte membrane receptors coupled to the Gq class of GTP binding proteins have been implicated in the development and ultimate decompensation of cardiac hypertrophy.	Norepinephrine	62-76	endothelin 1	Mus musculus	48-60
2442626-2	1987	Noradrenaline (NA) released from sympathetic nerves acts on alpha 1-adrenoceptors to increase cytosolic Ca2+ and promote smooth muscle contraction.	Norepinephrine	0-13	carbonic anhydrase 2	Homo sapiens	104-107
3683595-0	1987	Inhibition of noradrenaline release via presynaptic 5-HT1B receptors of the rat vena cava.	Norepinephrine	14-27	5-hydroxytryptamine receptor 1B	Rattus norvegicus	52-58
9886882-1	1998	OBJECTIVES: Recently, in rat aortae, two putative digitalis-like factors, marinobufagenin and ouabain, were shown to interact with alpha-1 (sarcolemma) and alpha-3 (nerve endings) subunits of the sodium pump, respectively, and elicit vasoconstriction via inhibition of the Na+,K+-pump in vascular smooth muscle or norepinephrine release.	Norepinephrine	314-328	adrenoceptor alpha 1D	Homo sapiens	131-138
9819240-11	1998	In this same population of dorsal horn neurons, norepinephrine has a direct alpha1-mediated excitatory effect.	Norepinephrine	48-62	adrenoceptor alpha 1D	Homo sapiens	76-82
2441031-0	1987	The role of NADPH- and reduced glutathione-dependent enzymes in the norepinephrine modulation of the ATP-dependent, hepatic microsomal calcium pump: a new pathway for the noradrenergic regulation of cytosolic calcium in the hepatocyte.	Norepinephrine	68-82	2,4-dienoyl-CoA reductase 1	Homo sapiens	12-17
2441031-6	1987	At 10(-7) to 10(-6) M norepinephrine, with either NADP+ or NADPH, the uptake was significantly lower than at other norepinephrine concentrations.	Norepinephrine	22-36	2,4-dienoyl-CoA reductase 1	Homo sapiens	59-64
2441031-6	1987	At 10(-7) to 10(-6) M norepinephrine, with either NADP+ or NADPH, the uptake was significantly lower than at other norepinephrine concentrations.	Norepinephrine	115-129	2,4-dienoyl-CoA reductase 1	Homo sapiens	59-64
3032791-4	1987	The sensitivity of norepinephrine-precontracted aorta to ANP was significantly reduced in DOCA-salt hypertensive rats (p less than 0.001).	Norepinephrine	19-33	natriuretic peptide A	Rattus norvegicus	57-60
3595711-0	1987	Increases in CSF norepinephrine associated with the onset of digoxin-induced arrhythmias.	Norepinephrine	17-31	colony stimulating factor 2	Canis lupus familiaris	13-16
9722148-12	1998	Considering the importance of N-methyl-D-aspartate receptor activation and of noradrenaline in cognitive processes, the effects of gp120 and V3 described here may be relevant to the pathology of AIDS dementia.	Norepinephrine	78-91	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	131-143
9788975-0	1998	Inhibition of norepinephrine-induced cardiac hypertrophy in s100beta transgenic mice.	Norepinephrine	14-28	S100 protein, beta polypeptide, neural	Mus musculus	60-68
9648875-10	1998	These results suggest that norepinephrine terminals regulate extracellular dopamine concentrations in the medial prefrontal cortex and to a lesser extent in the nucleus accumbens shell through the uptake of dopamine by the norepinephrine transporter.	Norepinephrine	27-41	solute carrier family 6 member 2	Rattus norvegicus	223-249
3595711-2	1987	A continuous peripheral digoxin infusion produced significant increases in CSF norepinephrine just prior to arrhythmogenesis in anesthetized dogs.	Norepinephrine	79-93	colony stimulating factor 2	Canis lupus familiaris	75-78
2884590-0	1987	Behavioural and biochemical evidence for the release of noradrenaline in mouse brain by TRH and some of its biologically stable analogues.	Norepinephrine	56-69	thyrotropin releasing hormone	Mus musculus	88-91
9641484-1	1998	Nepicastat (RS-25560-197) is a novel, selective, and potent inhibitor of dopamine beta-hydroxylase, which modulates catecholamine levels (reduces norepinephrine and elevates dopamine) in cardiovascular tissues.	Norepinephrine	146-160	dopamine beta-hydroxylase	Rattus norvegicus	73-98
2884590-14	1987	Viewed overall, the data showed that TRH and its analogues induced the release of noradrenaline in the brain.	Norepinephrine	82-95	thyrotropin releasing hormone	Mus musculus	37-40
3575912-1	1987	Neuropeptide-Y (NPY) is a peptide co-localised with noradrenaline in many sympathetic nerves.	Norepinephrine	52-65	neuropeptide Y	Felis catus	0-14
9669490-2	1998	One such mediator is neuropeptide Y (NPY), which is co-localized with noradrenaline in sympathetic perivascular nerves.	Norepinephrine	70-83	neuropeptide Y	Homo sapiens	21-35
9669490-2	1998	One such mediator is neuropeptide Y (NPY), which is co-localized with noradrenaline in sympathetic perivascular nerves.	Norepinephrine	70-83	neuropeptide Y	Homo sapiens	37-40
3575912-1	1987	Neuropeptide-Y (NPY) is a peptide co-localised with noradrenaline in many sympathetic nerves.	Norepinephrine	52-65	neuropeptide Y	Felis catus	16-19
3544861-0	1987	Neurotensin releases norepinephrine differentially from perfused hypothalamus of sated and fasted rat.	Norepinephrine	21-35	neurotensin	Rattus norvegicus	0-11
3442342-5	1987	In addition, the pulmonary arterial blood temperature and the noradrenaline plasma concentrations (double isotope enzymatic assay) increased significantly during period 2.	Norepinephrine	62-75	period circadian regulator 2	Homo sapiens	162-170
2880980-4	1987	However, the digoxin-induce increase in CSF noradrenaline was decreased significantly in apomorphine-pretreated animals.	Norepinephrine	44-57	colony stimulating factor 2	Canis lupus familiaris	40-43
2880980-6	1987	As with apomorphine, pimozide-pretreated animals accumulated significantly less noradrenaline in CSF compared with control dogs.	Norepinephrine	80-93	colony stimulating factor 2	Canis lupus familiaris	97-100
2876643-6	1986	Injection of neostigmine (5 X 10(-8) mol), an inhibitor of cholinesterase, into the ventricle resulted in the increase of not only glucose, but also glucagon, epinephrine, and norepinephrine in the hepatic venous plasma.	Norepinephrine	176-190	butyrylcholinesterase	Rattus norvegicus	59-73
9435281-5	1998	In particular, we show that, in the absence of MASH1, these neurons fail to initiate expression of the noradrenaline biosynthetic enzyme dopamine beta-hydroxylase.	Norepinephrine	103-116	dopamine beta-hydroxylase	Homo sapiens	137-162
9475874-4	1998	When administered in the presence of norepinephrine, 10(-8) and 10(-7) M NPY (n = 6) produced extreme increases in Ppa to 66.1 +/- 20.5 and 114.7 +/- 25.5 mmHg, respectively, that were due primarily to an increased arterial resistance.	Norepinephrine	37-51	neuropeptide Y	Oryctolagus cuniculus	73-76
9535054-11	1998	Our data suggest the presence of several distinct types of catecholamine receptors in the rat intermediate lobe, and the dominant involvement of D-2 and beta-adrenergic receptors in the noradrenaline-induced regulation of melanotropes.	Norepinephrine	186-199	solute carrier family 3 member 1	Rattus norvegicus	145-148
9483533-6	1998	The norepinephrine-induced calcium current inhibition was mediated by alpha 2-adrenergic receptors; it was mimicked by UK 14304, an alpha 2-adrenergic receptor agonist and blocked by idazoxan, an alpha 2-adrenergic receptor antagonist, but not affected by prazosin or propanolol (alpha 1 and beta adrenergic antagonists, respectively).	Norepinephrine	4-18	adrenoceptor alpha 1D	Homo sapiens	280-296
9539874-0	1998	Effects of norepinephrine on expression of IGF-1/IGF-1R and SERCA2 in rat heart.	Norepinephrine	11-25	insulin-like growth factor 1	Rattus norvegicus	43-48
3800944-0	1986	Effect of adenosine deaminase, N6-phenylisopropyladenosine and hypothyroidism on the responsiveness of rat brown adipocytes to noradrenaline.	Norepinephrine	127-140	adenosine deaminase	Rattus norvegicus	10-29
9366411-2	1997	In the present study, we proposed that the level of beta 2AR expression on anti-CD3 mAb-activated CD4+ effector Th cells may differ from the level on resting cells, and that a change in receptor expression may alter the functional responsiveness of these cells to either the beta 2AR-selective ligand terbutaline or the sympathetic neurotransmitter norepinephrine.	Norepinephrine	349-363	adrenergic receptor, beta 2	Mus musculus	52-60
9366411-9	1997	Additionally, norepinephrine down-modulates IL-2, but not IFN-gamma, production by binding specifically to the beta-adrenergic receptor.	Norepinephrine	14-28	interleukin 2	Mus musculus	44-48
9348548-4	1997	Substantial regional differences in the density and distribution of CRH-immunoreactive axons were found in the dopamine-, noradrenaline- and serotonin-containing cell body regions of the human brainstem.	Norepinephrine	122-135	corticotropin releasing hormone	Homo sapiens	68-71
9403317-4	1997	Norepinephrine and epinephrine operate through differential recruitment of alpha 2- and beta-AR subtypes on the basis of their relative affinity for the different subtypes (the relative order of affinity is alpha 2 &gt; beta 1 &gt; or = beta 2 &gt; beta 3 for norepinephrine).	Norepinephrine	0-14	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	249-255
3800944-1	1986	Adenosine deaminase (1 unit/ml) potentiated the lipolytic action of noradrenaline in adipocytes isolated from brown adipose tissue of 1- and 6-week-old rats by decreasing the EC50 (concn.	Norepinephrine	68-81	adenosine deaminase	Rattus norvegicus	0-19
3800944-3	1986	With cells from neonatal rabbit tissue, adenosine deaminase only had a small, non-significant, effect on the EC50 for noradrenaline.	Norepinephrine	118-131	adenosine deaminase	Oryctolagus cuniculus	40-59
3800944-8	1986	Responsiveness of lipolysis to noradrenaline was particularly decreased in hypothyroidism and was partially restored by addition of adenosine deaminase.	Norepinephrine	31-44	adenosine deaminase	Rattus norvegicus	132-151
3016179-1	1986	Pineal cyclic AMP and cyclic GMP are regulated by norepinephrine (NE) acting through alpha 1- and beta-adrenoceptors.	Norepinephrine	50-64	5'-nucleotidase, cytosolic II	Homo sapiens	29-32
2871469-9	1986	Catecholamine had different effects on TRH levels in RMN and the controls; this might be due to the excess accumulation of noradrenaline in the RMN brain.	Norepinephrine	123-136	thyrotropin releasing hormone	Mus musculus	39-42
3085873-0	1986	Stimulation by gastrin-releasing peptide, neurotensin and DN1417, a novel TRH analog, of dopamine and norepinephrine release from perifused rat hypothalamic fragments in vitro.	Norepinephrine	102-116	gastrin releasing peptide	Rattus norvegicus	15-40
3742254-0	1986	Effects of neurotensin on regional concentrations of norepinephrine in rat brain.	Norepinephrine	53-67	neurotensin	Rattus norvegicus	11-22
3742254-1	1986	The effects of intraventricular administration of either 7.5 or 30 micrograms neurotensin on norepinephrine concentrations were examined in several brain regions at 5 or 30 min post-injection.	Norepinephrine	93-107	neurotensin	Rattus norvegicus	78-89
2420199-1	1986	We investigated the role of calcium and calmodulin as intracellular mediators of kallikrein and tonin release induced by norepinephrine (NE).	Norepinephrine	121-135	kallikrein 1-related peptidase C2	Rattus norvegicus	96-101
3005093-1	1986	The response to insulin-induced hypoglycemia includes increased plasma levels of glucagon, epinephrine, norepinephrine, cortisol, and growth hormone.	Norepinephrine	104-118	insulin	Canis lupus familiaris	16-23
3005829-8	1986	In competition studies, alpha-adrenergic antagonists and agonists inhibited the binding of 125I-rau-pAPC with a potency order consistent with an interaction at alpha 2-adrenergic receptors (rauwolscine greater than phentolamine greater than prazosin; clonidine greater than (-)-epinephrine greater than (-)-norepinephrine greater than dopamine greater than (+)-epinephrine).	Norepinephrine	303-321	protocadherin 8	Homo sapiens	100-104
2935881-5	1986	Furthermore, ANF suppressed the compensatory increase of norepinephrine excretion secondary to adrenalectomy.	Norepinephrine	57-71	natriuretic peptide A	Rattus norvegicus	13-16
3008207-7	1986	As both serotonin and norepinephrine are preferentially metabolized by MAO-A rather than MAO-B, an increased availability of serotonin (the precursor of melatonin) or enhanced noradrenergic function might mediate the melatonin changes observed to follow MAO-A but not MAO-B inhibition.	Norepinephrine	22-36	monoamine oxidase B	Homo sapiens	89-94
3008207-7	1986	As both serotonin and norepinephrine are preferentially metabolized by MAO-A rather than MAO-B, an increased availability of serotonin (the precursor of melatonin) or enhanced noradrenergic function might mediate the melatonin changes observed to follow MAO-A but not MAO-B inhibition.	Norepinephrine	22-36	monoamine oxidase B	Homo sapiens	268-273
3010387-6	1986	Thirdly, NPY and PYY act prejunctionally in that they suppress the release of noradrenaline from sympathetic nerve endings upon stimulation; this was studied in the rat vas deferens.	Norepinephrine	78-91	peptide YY	Rattus norvegicus	17-20
3010387-10	1986	The NPY- and PYY-induced suppression of noradrenaline release from the prostatic portion of the rat vas deferens was reproduced by PYY 13-36 but not by the shorter fragments nor by desamido-NPY.	Norepinephrine	40-53	peptide YY	Rattus norvegicus	13-16
3010387-10	1986	The NPY- and PYY-induced suppression of noradrenaline release from the prostatic portion of the rat vas deferens was reproduced by PYY 13-36 but not by the shorter fragments nor by desamido-NPY.	Norepinephrine	40-53	peptide YY	Rattus norvegicus	131-134
3028057-3	1986	The purpose of the present study was to investigate the effects of norepinephrine, isoproterenol, methacholine, and cholecystokinin on the simultaneous release of kallikrein and tonin from the rat submandibular gland.	Norepinephrine	67-81	kallikrein 1-related peptidase C2	Rattus norvegicus	178-183
3028057-7	1986	Similarly, norepinephrine at 10(-5) M enhanced the release of tonin from a basal rate of 4.4 +/- 0.6 to 57 +/- 14.4 ng/min/mg tissue (p less than .05), and at 10(-4) M the rate increased to 91.3 +/- 20.0 ng/min/mg tissue (p less than .01).	Norepinephrine	11-25	kallikrein 1-related peptidase C2	Rattus norvegicus	62-67
9421826-0	1997	Alprazolam, diazepam, yohimbine, clonidine: in vivo CA1 hippocampal norepinephrine and serotonin release profiles under chloral hydrate anesthesia.	Norepinephrine	68-82	carbonic anhydrase 1	Rattus norvegicus	52-55
2946967-0	1986	Norepinephrine-induced acute renal failure: beneficial effects of atrial natriuretic factor.	Norepinephrine	0-14	natriuretic peptide A	Rattus norvegicus	66-91
9334997-0	1997	Angiotensin converting enzyme inhibition improves baroreflex-induced noradrenaline spillover responses in rabbits with heart failure.	Norepinephrine	69-82	angiotensin-converting enzyme	Oryctolagus cuniculus	0-29
9389931-3	1997	Dexamethasone and noradrenaline suppressed secretion of IL-2, IFN alpha, IFN gamma, TNF alpha, IL-1 alpha and IL-1 beta.	Norepinephrine	18-31	interleukin 1 alpha	Homo sapiens	95-105
2946967-1	1986	The effect of the atrial natriuretic factor (ANF) on early norepinephrine-induced acute renal failure (ARF) was investigated.	Norepinephrine	59-73	natriuretic peptide A	Rattus norvegicus	18-43
2946967-1	1986	The effect of the atrial natriuretic factor (ANF) on early norepinephrine-induced acute renal failure (ARF) was investigated.	Norepinephrine	59-73	natriuretic peptide A	Rattus norvegicus	45-48
2932194-3	1985	Synthetic ANF was found to cause relaxation of the renal vessels when these were sub-maximally activated with K+, noradrenaline or 5-hydroxytryptamine, but had no effect on the responses of the other vessels to these agonists.	Norepinephrine	114-127	natriuretic peptide A	Rattus norvegicus	10-13
9288221-1	1997	Neuropeptide Y (NPY) is co-localized with noradrenaline (NA) in perivascular sympathetic nerve and is a vasoconstrictor.	Norepinephrine	42-55	neuropeptide Y	Homo sapiens	0-14
9288221-1	1997	Neuropeptide Y (NPY) is co-localized with noradrenaline (NA) in perivascular sympathetic nerve and is a vasoconstrictor.	Norepinephrine	42-55	neuropeptide Y	Homo sapiens	16-19
9214397-1	1997	Neuropeptide Y (NPY) is a peptide hormone that is expressed, stored, and released in sympathetic neurones together with noradrenaline.	Norepinephrine	120-133	neuropeptide Y	Homo sapiens	0-14
9214397-1	1997	Neuropeptide Y (NPY) is a peptide hormone that is expressed, stored, and released in sympathetic neurones together with noradrenaline.	Norepinephrine	120-133	neuropeptide Y	Homo sapiens	16-19
9533823-2	1997	The present study was carried out with the aim of elucidating the mechanism of PAF action on vasoconstrictive response to noradrenaline (NA-R) in the presence of autologous platelets.	Norepinephrine	122-135	PCNA clamp associated factor	Homo sapiens	79-82
9533823-2	1997	The present study was carried out with the aim of elucidating the mechanism of PAF action on vasoconstrictive response to noradrenaline (NA-R) in the presence of autologous platelets.	Norepinephrine	137-141	PCNA clamp associated factor	Homo sapiens	79-82
9533823-4	1997	PAF action through stimulation of platelets by noradrenaline (NA) was explored during infusion of platelet rich plasma (PRP) with PAF into the perfusion circuit.	Norepinephrine	47-60	PCNA clamp associated factor	Homo sapiens	0-3
9533823-8	1997	Thus, it is concluded that PAF action on NA-R through platelets may be related partly to neurotransmitters originating from perivascular autonomic depressant nerves stimulated by some neuroeffector agents.	Norepinephrine	41-45	PCNA clamp associated factor	Homo sapiens	27-30
3903555-3	1985	Strongly GR immunoreactive nerve cells were mainly found in the area of the noradrenaline, adrenaline and 5-hydroxytryptamine (5-HT) cell groups of the lower brain stem, and of the substantia gelatinosa of the nuc.	Norepinephrine	76-89	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	9-11
3161659-0	1985	Atrial natriuretic factor inhibits the hypertension induced by chronic infusion of norepinephrine in conscious rats.	Norepinephrine	83-97	natriuretic peptide A	Rattus norvegicus	0-25
9160936-12	1997	Adrenomedullin, a novel peptide with known vasodilator properties, relaxed vascular smooth muscle in all three groups and also attenuated the pressor response to norepinephrine.	Norepinephrine	162-176	adrenomedullin	Canis lupus familiaris	0-14
9213209-5	1997	NPY, its endogenous analog, peptide YY, and its C-terminal fragment, NPY13-36, but not its analog, [Leu31,Pro34]NPY, concentration dependently (1-100 nM) inhibited [3H]noradrenaline release in all tissues studied.	Norepinephrine	168-181	neuropeptide Y	Homo sapiens	0-3
3161659-3	1985	When the same dose of atrial natriuretic factor was administered simultaneously with 1.8 mg/kg per day of norepinephrine infused intraperitoneally by osmotic minipumps, the systolic blood pressure of conscious rats rose on day 1 to only 127.3 +/- 6.3 mm Hg compared with the rise to 146.3 +/- 1.6 mm Hg when norepinephrine alone was infused (P less than 0.05).	Norepinephrine	308-322	natriuretic peptide A	Rattus norvegicus	22-47
9213209-5	1997	NPY, its endogenous analog, peptide YY, and its C-terminal fragment, NPY13-36, but not its analog, [Leu31,Pro34]NPY, concentration dependently (1-100 nM) inhibited [3H]noradrenaline release in all tissues studied.	Norepinephrine	168-181	neuropeptide Y	Homo sapiens	69-72
9213209-7	1997	We conclude that prejunctional inhibition of noradrenaline release in human heart and human and rabbit kidney occurs through NPY receptors of the Y2 subtype, which appear to couple to a pertussis toxin-sensitive G protein.	Norepinephrine	45-58	neuropeptide Y	Oryctolagus cuniculus	125-128
3161659-4	1985	The antihypertensive effect of atrial natriuretic factor was sustained for 3 days in rats infused with norepinephrine.	Norepinephrine	103-117	natriuretic peptide A	Rattus norvegicus	31-56
3161659-5	1985	The administration of atrial natriuretic factor to rats made hypertensive by 3 days of infusion with norepinephrine alone returned the blood pressure to control levels, and the antihypertensive effect was sustained throughout the experimental period lasting for 3 days.	Norepinephrine	101-115	natriuretic peptide A	Rattus norvegicus	22-47
2992694-2	1985	In caudal regions, GAD-stained cells were adjacent to the "precerebellar" lateral reticular nucleus and partially overlapped the A1 area of norepinephrine synthesizing neurons.	Norepinephrine	140-154	glutamate decarboxylase 1	Homo sapiens	19-22
9126981-2	1997	The sympathetic neurotransmitter norepinephrine modulates the level of T and B lymphocyte activity by binding to the beta2-adrenergic receptor (beta2AR).	Norepinephrine	33-47	adrenergic receptor, beta 2	Mus musculus	117-142
9126981-2	1997	The sympathetic neurotransmitter norepinephrine modulates the level of T and B lymphocyte activity by binding to the beta2-adrenergic receptor (beta2AR).	Norepinephrine	33-47	adrenergic receptor, beta 2	Mus musculus	144-151
9251764-3	1997	We have found that nitric oxide (NO) controls luteinizing hormone-releasing hormone (LHRH) release from the hypothalamus acting as a signal transducer in norepinephrine (NE)-induced LHRH release.	Norepinephrine	154-168	gonadotropin releasing hormone 1	Rattus norvegicus	46-83
9251764-3	1997	We have found that nitric oxide (NO) controls luteinizing hormone-releasing hormone (LHRH) release from the hypothalamus acting as a signal transducer in norepinephrine (NE)-induced LHRH release.	Norepinephrine	154-168	gonadotropin releasing hormone 1	Rattus norvegicus	85-89
9251764-3	1997	We have found that nitric oxide (NO) controls luteinizing hormone-releasing hormone (LHRH) release from the hypothalamus acting as a signal transducer in norepinephrine (NE)-induced LHRH release.	Norepinephrine	154-168	gonadotropin releasing hormone 1	Rattus norvegicus	182-186
9112832-3	1997	Superimposition of norepinephrine and gauche forms of serotonin and mociobemide suggest that the phenyl ring, electronegative group attached to the aromatic ring and the amine terminal group may serve as the recognition elements for binding to monoamine oxidase-A (MAO-A).	Norepinephrine	19-33	monoamine oxidase A	Homo sapiens	244-263
9112832-3	1997	Superimposition of norepinephrine and gauche forms of serotonin and mociobemide suggest that the phenyl ring, electronegative group attached to the aromatic ring and the amine terminal group may serve as the recognition elements for binding to monoamine oxidase-A (MAO-A).	Norepinephrine	19-33	monoamine oxidase A	Homo sapiens	265-270
9091308-5	1997	After pre-incubation with PDGF-AB or TGF-beta 1 in the presence of CRH or ACTH, norepinephrine and epinephrine release falls.	Norepinephrine	80-94	corticotropin releasing hormone	Homo sapiens	67-70
9074703-8	1997	Plasma SSAO correlated with plasma atrial natriuretic peptide (r = 0.42; P &lt; 0.0001), with plasma norepinephrine (r = 0.27; P &lt; 0.0001) and with left ventricular ejection fraction (r = -0.13; P = 0.0162).	Norepinephrine	101-115	amine oxidase copper containing 2	Homo sapiens	7-11
9152617-1	1997	Noradrenaline (NA) is one of the most important neurotransmitters involved in the regulation of gonadotropin-releasing hormone (GnRH) secretion.	Norepinephrine	0-13	gonadotropin releasing hormone 1	Mus musculus	96-126
9152617-1	1997	Noradrenaline (NA) is one of the most important neurotransmitters involved in the regulation of gonadotropin-releasing hormone (GnRH) secretion.	Norepinephrine	0-13	gonadotropin releasing hormone 1	Mus musculus	128-132
9023284-3	1997	By studying influence of appropriate adrenoceptor blockers, qualitative characteristics of the inotropic response and sensitivity of the inotropic response to cholinergic stimulation, it was revealed that norepinephrine evoked both alpha-1 and beta adrenoceptor-mediated inotropic effects in failing human ventricle myocardium.	Norepinephrine	205-219	adrenoceptor alpha 1D	Homo sapiens	232-248
2995061-2	1985	A first series of experiments served to assess the responsiveness of CA3 hippocampal pyramidal neurons to microiontophoretically applied serotonin (5-HT) and norepinephrine (NE).	Norepinephrine	158-172	carbonic anhydrase 3	Rattus norvegicus	69-72
3930975-2	1985	Isoprenaline, adrenaline and noradrenaline stimulated pepsinogen release in a dose-dependent manner with similar maximal effects, but isoprenaline was significantly more potent than the other two agonists.	Norepinephrine	29-42	pepsin II-2/3	Oryctolagus cuniculus	54-64
4069759-2	1985	The mechanism whereby norepinephrine elicits thrombosis during intravascular coagulation was investigated further in rabbits given a 4 h infusion of thrombin (1 NIH unit/kg/min).	Norepinephrine	22-36	prothrombin	Oryctolagus cuniculus	149-157
4069759-6	1985	Study of the glomerular circulation with colloidal carbon showed that norepinephrine elicits severe glomerular capillary stasis in thrombin treated rabbits; the vasomotor reaction precedes increased fibrinogen consumption and focal deposition of fibrin in the glomeruli.	Norepinephrine	70-84	prothrombin	Oryctolagus cuniculus	131-139
3997236-6	1985	Both plasma norepinephrine levels and the fall in mean arterial pressure after ganglionic blockade decreased during intrarenal adenosine deaminase infusion in one-kidney, one-clip animals.	Norepinephrine	12-26	adenosine deaminase	Rattus norvegicus	127-146
3997236-7	1985	Renal denervation in one-kidney, one-clip animals prevented the changes in mean arterial pressure and plasma norepinephrine levels during intrarenal adenosine deaminase infusion.	Norepinephrine	109-123	adenosine deaminase	Rattus norvegicus	149-168
2988261-1	1985	Noradrenaline (NA) exerts its physiological and pharmacological effects in the central nervous system by interacting with specific receptor sites which are divided into four subtypes, namely alpha-1, alpha-2, beta-1 and beta-2 adrenoceptors.	Norepinephrine	0-13	hemoglobin, beta adult minor chain	Mus musculus	220-226
2579383-1	1985	Noradrenaline, apparently working through activation of beta-adrenergic receptors, alters the state of phosphorylation of a substantial proportion of synapsin I in rat frontal cortex.	Norepinephrine	0-13	synapsin I	Rattus norvegicus	150-160
2579383-2	1985	Since synapsin I is enriched in virtually all axon terminals in this brain region, the results indicate that noradrenaline, a sparsely distributed neurotransmitter, affects a large number of axon terminals in this region.	Norepinephrine	109-122	synapsin I	Rattus norvegicus	6-16
2863929-6	1985	The "rules" for coexistence are not clear, since somatostatin coexist in some instances with norepinephrine, in other cases with GABA, and probably with other classical transmitters as well.	Norepinephrine	93-107	somatostatin	Homo sapiens	49-61
2990773-1	1985	The natriuretic substances were purified from rat atrium (ANF, atrial natriuretic factor) and were shown to be identical with the inhibitor of norepinephrine-induced contraction of smooth muscle.	Norepinephrine	143-157	natriuretic peptide A	Rattus norvegicus	58-61
2990773-1	1985	The natriuretic substances were purified from rat atrium (ANF, atrial natriuretic factor) and were shown to be identical with the inhibitor of norepinephrine-induced contraction of smooth muscle.	Norepinephrine	143-157	natriuretic peptide A	Rattus norvegicus	63-88
6097220-6	1984	Stimulation of mucin release by isoproterenol (10 microM), noradrenaline (10 microM) or adrenaline (10 microM) was inhibited by propranolol (30 microM) but not by phentolamine (30 microM).	Norepinephrine	59-72	solute carrier family 13 member 2	Rattus norvegicus	15-20
9023284-5	1997	Concomitant stimulation of alpha-1 and beta adrenoceptors by norepinephrine alone revealed a contribution of an alpha-1 adrenoceptor-mediated component to the final and unopposed inotropic response.	Norepinephrine	61-75	adrenoceptor alpha 1D	Homo sapiens	27-43
6242556-4	1984	A significantly smaller augmentation of the natriuretic response to ANF was produced by equipressor does of norepinephrine and epinephrine, suggesting that the potentiation by ANG II and AVP were not entirely due to increased mean arterial pressure (MAP).	Norepinephrine	108-122	natriuretic peptide A	Rattus norvegicus	68-71
8988954-7	1997	RESULTS: CSF norepinephrine concentration was significantly higher in the patients with advanced Alzheimer"s disease (mean = 279 pg/ml, SD = 122) than in those with mild to moderate severity (mean = 198 pg/ml, SD = 89), normal older subjects (mean = 219 pg/ml, SD = 88), or normal young subjects (mean = 154 pg/ml, SD = 53).	Norepinephrine	13-27	colony stimulating factor 2	Homo sapiens	9-12
8988954-9	1997	CONCLUSIONS: Despite the loss of locus ceruleus neurons in Alzheimer"s disease, the aging-associated high concentration of CSF norepinephrine is retained in the earlier stages of Alzheimer"s disease and increases further as the disease progresses.	Norepinephrine	127-141	colony stimulating factor 2	Homo sapiens	123-126
6091272-1	1984	Norepinephrine, briefly superfused during high-frequency stimulation of the mossy fibers in the rat hippocampal slice in vitro, produced a reversible increase in the magnitude, duration, and probability of induction of long-term synaptic potentiation in the CA3 subfield.	Norepinephrine	0-14	carbonic anhydrase 3	Rattus norvegicus	258-261
6492007-3	1984	The distribution of intracellular Ca2+ was determined, with electron probe X-ray microanalysis, in cryosections of preparations frozen in the relaxed state and at the peak of noradrenaline-induced contractions.	Norepinephrine	175-188	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	34-37
6492007-7	1984	The amplitude of reproducible interrupted contractions in Ca2+-free, high-K+ solution was graded with noradrenaline concentration.	Norepinephrine	102-115	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	58-61
6492007-14	1984	is the store from which noradrenaline and caffeine release Ca2+.	Norepinephrine	24-37	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	59-62
6146513-8	1984	In separate experiments, bilateral stimulation of the splanchnic nerves or pancreatic arterial infusion of norepinephrine to a final concentration of 60 microM decreased ISR and the somatostatin secretion rate (SSR).	Norepinephrine	107-121	somatostatin	Homo sapiens	182-194
6092250-7	1984	Degradation of released adenosine by addition of adenosine deaminase significantly enhanced the noradrenaline action on glycerol release in both groups of sand rats.	Norepinephrine	96-109	adenosine deaminase	Rattus norvegicus	49-68
9088896-10	1997	It may be assumed that noradrenaline released from degenerating sympathetic neurons located at the superior cervical ganglia (SCG) affects the GnRH-ergic terminals in the median eminence.	Norepinephrine	23-36	gonadotropin releasing hormone 1	Rattus norvegicus	143-147
6092250-8	1984	Even though the noradrenaline-stimulated lipolytic activity of adipose tissue from normo- and hyperglycemic animals was enhanced in the presence of adenosine deaminase, the hormone resistance of adipose tissue from hyperglycemic sand rats was nevertheless not abolished.	Norepinephrine	16-29	adenosine deaminase	Rattus norvegicus	148-167
6086876-2	1984	The magnitude and kinetics of the enhanced antibody response to norepinephrine alone, or to norepinephrine in the presence of phentolamine, were more closely mimicked with a beta-2 adrenoceptor agonist (terbutaline) than with a beta-1 adrenoceptor agonist (dobutamine).	Norepinephrine	64-78	adrenergic receptor, beta 1	Mus musculus	228-247
9023776-0	1997	Protein kinase A-mediated enhancement of miniature IPSC frequency by noradrenaline in rat cerebellar stellate cells.	Norepinephrine	69-82	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	0-16
6145466-4	1984	alpha-Adrenoceptor agonists such as noradrenaline stimulated kallikrein-like esterase and tonin release in a dose-dependent manner, whereas the beta-adrenoceptor agonist isoprenaline and cholinoceptor agonist methacoline were both inactive.	Norepinephrine	36-49	kallikrein 1-related peptidase C2	Rattus norvegicus	90-95
6145466-5	1984	Noradrenaline-induced release of kallikrein-like esterase and tonin were completely blocked by prior addition of the alpha-adrenoceptor antagonist, phenoxybenzamine.	Norepinephrine	0-13	kallikrein 1-related peptidase C2	Rattus norvegicus	62-67
6144271-1	1984	Norepinephrine is generally regarded as an inhibitor of insulin release.	Norepinephrine	0-14	insulin	Canis lupus familiaris	56-63
6144271-2	1984	It has been shown, however, that under hyperglycemic circumstances, norepinephrine infused at a high dose may also stimulate insulin secretion.	Norepinephrine	68-82	insulin	Canis lupus familiaris	125-132
6144271-6	1984	Norepinephrine stimulated insulin, somatostatin, and glucagon secretion without significant changes in either blood glucose concentration or pancreaticoduodenal venous blood flow.	Norepinephrine	0-14	insulin	Canis lupus familiaris	26-33
6144271-8	1984	Because bilateral cervical vagotomy prevented stimulation of insulin secretion by norepinephrine, central neural pathways must have been involved in the stimulatory process.	Norepinephrine	82-96	insulin	Canis lupus familiaris	61-68
6089134-6	1984	These findings are consistent with a hyperactivity of norepinephrine pathways in spontaneously hypertensive rats, leading to a reduced number of cardiac post-junctional secretin/VIP receptors bound to adenylate cyclase.	Norepinephrine	54-68	secretin	Rattus norvegicus	169-177
6316932-1	1983	The rate of noradrenaline-stimulated lipolysis is lower in fat-cells from lactating than from pregnant rats; this difference is eliminated by the addition of adenosine deaminase [Aitchison, Clegg &amp; Vernon (1982) Biochem.	Norepinephrine	12-25	adenosine deaminase	Rattus norvegicus	158-177
9364202-2	1997	On the other hand, IR1 possess low affinity for norepinephrine (NE) and other catecholamines.	Norepinephrine	48-62	nischarin	Homo sapiens	19-22
8982508-13	1996	This effect was antagonized by the selective protein kinase A (PKA) antagonist, Rp-8-chloroadenosine 3",5"-cyclic monophosphorothioate (RClcAMPS, 300 microM), suggesting that PKA activation enhances basal noradrenaline biosynthesis in sympathetic nerve terminals.	Norepinephrine	205-218	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	45-61
8982508-13	1996	This effect was antagonized by the selective protein kinase A (PKA) antagonist, Rp-8-chloroadenosine 3",5"-cyclic monophosphorothioate (RClcAMPS, 300 microM), suggesting that PKA activation enhances basal noradrenaline biosynthesis in sympathetic nerve terminals.	Norepinephrine	205-218	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	63-66
8982508-13	1996	This effect was antagonized by the selective protein kinase A (PKA) antagonist, Rp-8-chloroadenosine 3",5"-cyclic monophosphorothioate (RClcAMPS, 300 microM), suggesting that PKA activation enhances basal noradrenaline biosynthesis in sympathetic nerve terminals.	Norepinephrine	205-218	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	175-178
8922360-4	1996	Interestingly, both norepinephrine and isoproterenol reduced the level of leptin mRNA to about 20% of that found in untreated control cells in a dose-dependent fashion.	Norepinephrine	20-34	leptin	Homo sapiens	74-80
8961076-6	1996	Pretreatment of aortas with a cyclooxygenase inhibitor, indomethacin (10(-5) M) caused a slight decrease in the norepinephrine-induced contractions, suggesting that the factor could be a vasoconstrictor cyclooxygenase metabolite or a vasodilatory lipoxygenase or cytochrome P450 epoxygenase metabolite.	Norepinephrine	112-126	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	247-259
8961076-8	1996	Whereas the lipoxygenase inhibitor, nordihydroguaiaretic acid (5 x 10(-5) M), caused a slight increase in the contractions to norepinephrine in cholesterol-fed rabbits compared with normal rabbits, the cytochrome P450 epoxygenase inhibitor, metyrapone (10(-4) M), produced a greater enhancement of norepinephrine-induced contractions in cholesterol-fed rabbits but had no effect on responses in the normal rabbits.	Norepinephrine	126-140	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	12-24
8961076-8	1996	Whereas the lipoxygenase inhibitor, nordihydroguaiaretic acid (5 x 10(-5) M), caused a slight increase in the contractions to norepinephrine in cholesterol-fed rabbits compared with normal rabbits, the cytochrome P450 epoxygenase inhibitor, metyrapone (10(-4) M), produced a greater enhancement of norepinephrine-induced contractions in cholesterol-fed rabbits but had no effect on responses in the normal rabbits.	Norepinephrine	298-312	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	12-24
8961076-9	1996	Characterization of [3H]arachidonic acid metabolism in cholesterol-fed aortic tissue indicated that norepinephrine stimulated the synthesis of both lipoxygenase and epoxygenase metabolites in an endothelium-dependent manner.	Norepinephrine	100-114	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	148-160
6137369-11	1983	Hypokalaemia and raised levels of noradrenaline are also known to occur under such stressful conditions as acute myocardial infarction, when circulating levels of the endogenous beta 2-adrenoceptor agonist adrenaline are high.	Norepinephrine	34-47	adrenoceptor beta 2	Homo sapiens	178-197
8982651-0	1996	Neuropeptide Y potentiates noradrenaline-induced contraction through the neuropeptide Y Y1 receptor.	Norepinephrine	27-40	neuropeptide Y	Homo sapiens	0-14
8982651-0	1996	Neuropeptide Y potentiates noradrenaline-induced contraction through the neuropeptide Y Y1 receptor.	Norepinephrine	27-40	neuropeptide Y	Homo sapiens	73-87
8982651-2	1996	Neuropeptide Y significantly potentiated the noradrenaline-induced contraction in non-incubated vessels (pEC50 6.4 +/- 0.2 vs. 5.9 +/- 0.2) and in vessels incubated with 1 microM Sense oligodeoxynucleotide (Sense) (pEC50 6.0 +/- 0.1 vs. 5.6 +/- 0.2).	Norepinephrine	45-58	neuropeptide Y	Homo sapiens	0-14
6298402-2	1983	Intrarenal infusions of norepinephrine and epinephrine at doses adjusted to reduce renal blood flow by 20 and 50% of baseline values elicited renin release that was not completely blocked by either alpha adrenoceptor blockade with phentolamine or beta adrenoceptor blockade with propranolol.	Norepinephrine	24-38	renin	Canis lupus familiaris	142-147
6298402-5	1983	These data are consistent with the hypothesis that norepinephrine and epinephrine stimulate renin release by activation of both the renal beta and renal alpha adrenoceptors.	Norepinephrine	51-65	renin	Canis lupus familiaris	92-97
8982651-6	1996	On the basis of our results we conclude that the neuropeptide Y-induced potentiation of the noradrenaline-induced contraction is mediated by the neuropeptide Y Y1 receptor.	Norepinephrine	92-105	neuropeptide Y	Homo sapiens	49-63
6847818-0	1983	Neurotensin-like immunoreactivity in a subpopulation of noradrenaline-containing cells of the cat adrenal gland.	Norepinephrine	56-69	neurotensin	Bos taurus	0-11
8982651-6	1996	On the basis of our results we conclude that the neuropeptide Y-induced potentiation of the noradrenaline-induced contraction is mediated by the neuropeptide Y Y1 receptor.	Norepinephrine	92-105	neuropeptide Y	Homo sapiens	145-159
9116208-0	1996	Neuropeptide Y elevates intracellular Ca2+ and evokes noradrenaline release in SH-SY5Y cells.	Norepinephrine	54-67	neuropeptide Y	Homo sapiens	0-14
6847818-3	1983	Using immunocytochemical procedures at both light and ultrastructural levels, a neurotensin-like immunoreactive material was localized to a subpopulation of noradrenaline-containing cells quite distinct from the previously described enkephalin-immunoreactive chromaffin cells.	Norepinephrine	157-170	neurotensin	Bos taurus	80-91
6847818-5	1983	The finding of neurotensin-like immunoreactivity in noradrenaline-containing cells of the cat adrenal medulla provides further evidence in support of the postulated existence of heterogeneous subpopulations of noradrenaline-containing cells and suggests a possible functional interrelationship between neurotensin and catecholamine.	Norepinephrine	52-65	neurotensin	Bos taurus	15-26
8945965-5	1996	However, in the saline-infused subjects there was a positive correlation between the percent change in plasma norepinephrine concentrations and the percent change in muscle LPL activity (r = 0.826, P &lt; 0.05).	Norepinephrine	110-124	lipoprotein lipase	Homo sapiens	173-176
6847818-5	1983	The finding of neurotensin-like immunoreactivity in noradrenaline-containing cells of the cat adrenal medulla provides further evidence in support of the postulated existence of heterogeneous subpopulations of noradrenaline-containing cells and suggests a possible functional interrelationship between neurotensin and catecholamine.	Norepinephrine	210-223	neurotensin	Bos taurus	15-26
6131439-4	1983	Norepinephrine (20 micrograms ICV) induced feeding was suppressed at the 20 microgram neurotensin dose but not at the 10 microgram or 1 microgram dose.	Norepinephrine	0-14	neurotensin	Rattus norvegicus	86-97
6283915-2	1982	When given to slices maintained at 37 degrees C, the beta-agonists isoproterenol (ISP) and norepinephrine stimulated renin release from the slices.	Norepinephrine	91-105	renin	Canis lupus familiaris	117-122
8944402-3	1996	In comparison with lorazepam (2 mg), alprazolam (1 mg) showed reduced MBP levels during supine rest, whereas lorazepam showed a higher heart rate level during supine rest, a reduced plasma noradrenaline response to the OCT and a performance deterioration to the CWT.	Norepinephrine	189-202	plexin A2	Homo sapiens	219-222
8987112-0	1996	Different classes of PAF-antagonists block norepinephrine-induced vascular escape and tachyphylaxis in the isolated rabbit kidney.	Norepinephrine	43-57	PCNA clamp associated factor	Homo sapiens	21-24
8878434-7	1996	Preincubation of cells with insulin or IGF-I enhanced subsequent norepinephrine stimulation of mitogen activated kinase activity.	Norepinephrine	65-79	insulin-like growth factor 1	Rattus norvegicus	39-44
8938587-14	1996	Levels of mRNA encoding the glucocorticoid-dependent enzyme phenylethanolamine N-methyltransferase which catalyses the conversion of noradrenaline to adrenaline, were also significantly reduced in those rats given glycyrrhizic acid (1.12 +/- 0.04 vs 0.78 +/- 0.04), while those for the glucocorticoid-independent enzyme tyrosine hydroxylase (1.9 kb), which catalyses the conversion of tyrosine to DOPA, were unchanged (0.64 +/- 0.04 vs 0.61 +/- 0.04).	Norepinephrine	133-146	phenylethanolamine-N-methyltransferase	Rattus norvegicus	60-98
8781343-3	1996	Kupffer cells have been implicated as the source of prostanoids in the anaphylatoxin-dependent signalling chain and Ito cells in the nerve stimulation-dependent signalling chain, because anaphylatoxins and noradrenaline increased prostanoid synthesis in isolated Kupffer and Ito cells, respectively.	Norepinephrine	206-219	complement C5	Rattus norvegicus	71-84
8796125-0	1996	Norepinephrine induces cardiac heat shock protein 70 and delayed cardioprotection in the rat through alpha 1 adrenoceptors.	Norepinephrine	0-14	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	31-52
8702430-4	1996	A similar rise in GRF receptor gene expression was obtained by the depletion of noradrenaline, a neurotransmitter thought to stimulate GRF release, and was reversed by 87% by the repeated administration of synthetic GRF.	Norepinephrine	80-93	growth hormone releasing hormone receptor	Rattus norvegicus	18-30
8701243-9	1996	In the CSF of cluster headache patients norepinephrine (p &lt; 0.05), HVA (p &lt; 0.01), and 5-HIAA (p &lt; 0.01) were significantly decreased.	Norepinephrine	40-54	colony stimulating factor 2	Homo sapiens	7-10
8701243-10	1996	Plasma norepinephrine was correlated with CSF values of HVA and 5-HIAA.	Norepinephrine	7-21	colony stimulating factor 2	Homo sapiens	42-45
8695909-1	1996	Bacterial cells respond to monoamine compounds, such as tyramine, dopamine, octopamine, or norepinephrine, and induce the syntheses of tyramine oxidase encoded by tynA and monoamine oxidase encoded by maoA.	Norepinephrine	91-105	monoamine oxidase A	Homo sapiens	201-205
6283920-6	1982	Norepinephrine reversed the suppressive effect of bombesin but not that of cholecystokinin.	Norepinephrine	0-14	gastrin releasing peptide	Homo sapiens	50-58
7062033-3	1982	The release rates of noradrenaline and dopamine into artificial CSF perfusates were 38 +/- 6 and 46 +/- 6 pg/h (225 +/- 36 and 301 +/- 39 fmol/h), respectively; when 0.5 mM amphetamine was added to the CSF, the release rates of noradrenaline and dopamine increased to 176 +/- 50 and 1183 +/- 453 ph/h (1041 +/- 296 and 7732 +/- 2961 fmol/h), respectively.	Norepinephrine	21-34	colony stimulating factor 2	Rattus norvegicus	64-67
7062033-3	1982	The release rates of noradrenaline and dopamine into artificial CSF perfusates were 38 +/- 6 and 46 +/- 6 pg/h (225 +/- 36 and 301 +/- 39 fmol/h), respectively; when 0.5 mM amphetamine was added to the CSF, the release rates of noradrenaline and dopamine increased to 176 +/- 50 and 1183 +/- 453 ph/h (1041 +/- 296 and 7732 +/- 2961 fmol/h), respectively.	Norepinephrine	21-34	colony stimulating factor 2	Rattus norvegicus	202-205
6811784-1	1982	Rolling Mouse Nagoya (RMN), weaver and reeler mice were examined for the clinical effectiveness of drugs (thyrotropin releasing hormone (TRH), reserpine, L-dopa) that are reported to facilitate or alter the metabolic system of noradrenaline (NA).	Norepinephrine	227-240	thyrotropin releasing hormone	Mus musculus	106-135
6282271-7	1982	The noradrenaline-stimulated lipolysis rate rose above the virgin rate during pregnancy and fell below it during lactation; inclusion of adenosine deaminase in incubations abolished these differences in response to noradrenaline.	Norepinephrine	215-228	adenosine deaminase	Rattus norvegicus	137-156
8724036-10	1996	Finally, gp120 reversed (1 nM) and surmounted (10nM) the antagonism by 10 microM 7-chlorokynurenate of the NMDA-evoked [3H]-noradrenaline release.	Norepinephrine	124-137	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	9-14
8780011-0	1996	Noradrenaline increases the expression of the proenkephalin gene in cultured astroglial cells by acting on beta 1- and alpha 1-adrenoceptors.	Norepinephrine	0-13	proenkephalin	Rattus norvegicus	46-59
8780011-4	1996	In the present study, how noradrenaline affected the expression of the proenkephalin gene in both cell types was investigated.	Norepinephrine	26-39	proenkephalin	Rattus norvegicus	71-84
8792338-10	1996	Norepinephrine neurons of the locus coeruleus (A6) and subcoeruleus (A6v) exhibited significantly higher levels of GTP cyclohydrolase I mRNA than did neurons in other norepinephrine (A1 and A2) or epinephrine (C1 and C2) cell groups.	Norepinephrine	0-14	complement C2	Rattus norvegicus	210-219
8635209-1	1996	We have previously shown that extracellular ATP, like norepinephrine (NE) and many other hypertrophy-inducing agents, increases expression of the immediate-early genes c-fos and junB in cultured neonatal cardiac myocytes but that the intracellular signaling pathways activated by ATP and responsible for these changes differ from those stimulated by NE.	Norepinephrine	54-68	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	178-182
8925253-3	1996	DBH catalyzes the synthesis of norepinephrine from dopamine in noradrenergic neurons.	Norepinephrine	31-45	dopamine beta-hydroxylase	Homo sapiens	0-3
8740562-4	1996	Anti-D beta H-saporin, directed against dopamine beta-hydroxylase, the enzyme that converts dopamine to norepinephrine, selectively destroys noradrenergic neurons (sympathetic, CNS).	Norepinephrine	104-118	dopamine beta-hydroxylase	Homo sapiens	40-65
8710209-2	1996	Noradrenaline (NA) neurons in A1, A5, A7 regions, locus coeruleus (LC) and nucleus subcoeruleus (SC) and adrenaline (Ad) neurons in C1 region were double-labeled due to DBH or PNMT and retrogradely transported FluoSpheres, and the ratio of their coexistence was higher in A1, A5, A7 and C1 than in LC and SC.	Norepinephrine	0-13	dopamine beta-hydroxylase	Rattus norvegicus	169-172
7028613-1	1981	Sodium depletion, a maneuver that is accompanied by a 14-fold elevation of plasma renin activity (PRA), alters the norepinephrine concentration of the canine area postrema (AP), a circumventricular organ of the 4th ventricle known to be sensitive to circulating angiotensin II.	Norepinephrine	115-129	renin	Canis lupus familiaris	82-87
6271668-1	1981	The effect of continuous intrarenal infusion of norepinephrine, isoproterenol, and methoxamine on renin release was studied in the uninephrectomized conscious dog.	Norepinephrine	48-62	renin	Canis lupus familiaris	98-103
6271668-2	1981	Chronic intrarenal infusion of norepinephrine produced a biphasic curve of plasma renin activity (PRA) and a sustained 25 mm Hg increase in mean arterial pressure (MAP).	Norepinephrine	31-45	renin	Canis lupus familiaris	82-87
6266953-2	1981	Tonin potentiates the effect of norepinephrine (NE) in the rat mesenteric artery preparation and in the aortic strips from normal and hypertensive rats.	Norepinephrine	32-46	kallikrein 1-related peptidase C2	Rattus norvegicus	0-5
7253345-5	1981	C8-CCK (10(-9) g/ml) potentiated both contractile and relaxing responses to noradrenaline, in the gallbladder.	Norepinephrine	76-89	cholecystokinin	Cavia porcellus	3-6
20487821-2	1981	Cholecystokinin octapeptide sulphate ester and the tyrosine-sulphate-methionine and tyrosine-sulphate-methionine-glycine fragments increased the dopamine and norepinephrine contents of the hypothalamus and mesencephalon.	Norepinephrine	158-172	cholecystokinin	Rattus norvegicus	0-15
6993660-3	1980	In response to stimulation by norepinephrine and serotonin, aortic strips from 2 to 28 day AHR developed the same tension as controls, whereas aortas of 6 and 14 day AHR had reduced maximal responses.	Norepinephrine	30-44	aryl hydrocarbon receptor	Rattus norvegicus	91-94
6993660-3	1980	In response to stimulation by norepinephrine and serotonin, aortic strips from 2 to 28 day AHR developed the same tension as controls, whereas aortas of 6 and 14 day AHR had reduced maximal responses.	Norepinephrine	30-44	aryl hydrocarbon receptor	Rattus norvegicus	166-169
6167608-4	1980	The "apparent affinity" for neurotensin (pD2 = 7.5 +/- 0.3, S.D., n = 10) was about 10 times less than for angiotensin II while higher than for both the other peptides and for norepinephrine.	Norepinephrine	176-190	neurotensin	Rattus norvegicus	28-39
7353588-1	1980	After in vivo ligation for 24 of the cat hypogastric nerve, large amounts of noradrenaline (NA) and dopamine beta-hydroxylase (DBH) accumulated in the nerve segment immediately proximal to the ligature (P 1).	Norepinephrine	77-90	crystallin gamma F, pseudogene	Homo sapiens	203-206
43064-2	1979	The leakage of 125IHSA (human serum albumin) into the brains from rats given adrenaline was significantly larger than in the brains from rats given noradrenaline or angiotensin.	Norepinephrine	148-161	albumin	Rattus norvegicus	30-43
378326-6	1979	Interactions of neurotensin with other neurotransmitter candidates are also suggested by its presence in areas enriched in norepinephrine, dopamine, serotonin, and substance P. Certain neurotensin localizations suggest an association of the peptide with functional brain systems preferentially involving these regions.	Norepinephrine	123-137	neurotensin	Rattus norvegicus	16-27
217278-5	1979	The potentiation of exogenous norepinephrine by AII, AIII, and [des-Asp1-Arg2]AII was inhibited by [Sar1-Ile8]AII (110%, 113%, and 108%, respectively) and by [Ile7]AIII (50%, 64%, 91%, respectively).	Norepinephrine	30-44	arginase 2	Rattus norvegicus	73-77
8848277-4	1996	It is now shown that the marked increase in jun-B mRNA expression following norepinephrine stimulation in vitro, is mediated through a post-transcriptional mechanism that involves mRNA stabilization.	Norepinephrine	76-90	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	44-49
217278-6	1979	We conclude that AII possesses the capacity both to increase norpinephrine release during sympathetic nerve stimulation and to decrease norepinephrine reuptake, whereas AIII and [des-Asp1-Arg2]AII decrease norepinephrine release and reuptake.	Norepinephrine	206-220	arginase 2	Rattus norvegicus	188-192
220287-1	1979	C-6 glial tumor cells treated with norepinephrine and sodium azide accumulated cyclic GMP to concentrations approximately 10-fold greater than the sum of the separate responses.	Norepinephrine	35-49	5'-nucleotidase, cytosolic II	Homo sapiens	86-89
740049-8	1978	Both neurotensin and [Gln4]-neurotensin also accelerated the disappearance of dopamine, noradrenaline and 5-hydroxytryptamine after inhibition of monoamine synthesis.	Norepinephrine	88-101	neurotensin	Rattus norvegicus	5-16
740049-8	1978	Both neurotensin and [Gln4]-neurotensin also accelerated the disappearance of dopamine, noradrenaline and 5-hydroxytryptamine after inhibition of monoamine synthesis.	Norepinephrine	88-101	neurotensin	Rattus norvegicus	28-39
570404-1	1978	The effect of PLP on the noradrenaline-induced relaxation of coronary arteries was studied in vitro, after known inhibitor of COMT, Pyrogallol.	Norepinephrine	25-38	proteolipid protein 1	Homo sapiens	14-17
570404-2	1978	Relaxation of response to noradrenaline were increased by PLP.	Norepinephrine	26-39	proteolipid protein 1	Homo sapiens	58-61
570404-4	1978	It is concluded that PLP enhances the response of coronary smooth muscle to noradrenaline by inhibiting a enzymatic pathway for the inactivation of catecolamines.	Norepinephrine	76-89	proteolipid protein 1	Homo sapiens	21-24
674813-0	1978	Rat hippocampal norepinephrine response to cholinesterase inhibition.	Norepinephrine	16-30	butyrylcholinesterase	Rattus norvegicus	43-57
674813-2	1978	Results indicate that this cholinesterase inhibiting compound caused a significant decrease (congruent to 14%) in hippocampal norepinephrine within 3 hours of exposure.	Norepinephrine	126-140	butyrylcholinesterase	Rattus norvegicus	27-41
674817-3	1978	Following acute myocardial infarction, significant correlations were found to exist between plasma norepinephrine and plasma renin activity and between the levels of these vasoactive substances and the measured indices of ischemic damage.	Norepinephrine	99-113	renin	Canis lupus familiaris	125-130
668387-0	1978	Plasma renin activity in acute renal failure induced by norepinephrine infusion in unilaterally nephrectomized dogs.	Norepinephrine	56-70	renin	Canis lupus familiaris	7-12
861305-3	1977	It was found that human blood plasma after the contact with norepinephrine loses its ability to increase the BAEE-esterase activity, when tanic acid, which activates factor XII (Hageman factor), was added.	Norepinephrine	60-74	coagulation factor XII	Homo sapiens	178-192
11370235-10	1976	The data indicate that in pentobarbital anesthetized dogs, the increase in growth hormone secretion produced by L-dopa is mediated by norepinephrine, rather than dopamine, that the site of action of the norepinephrine is central, above the median eminence and inside the "blood-brain barrier", and that the norepinephrine acts via alpha-adrenergic receptors.	Norepinephrine	134-148	somatotropin	Canis lupus familiaris	75-89
11370235-10	1976	The data indicate that in pentobarbital anesthetized dogs, the increase in growth hormone secretion produced by L-dopa is mediated by norepinephrine, rather than dopamine, that the site of action of the norepinephrine is central, above the median eminence and inside the "blood-brain barrier", and that the norepinephrine acts via alpha-adrenergic receptors.	Norepinephrine	203-217	somatotropin	Canis lupus familiaris	75-89
11370235-10	1976	The data indicate that in pentobarbital anesthetized dogs, the increase in growth hormone secretion produced by L-dopa is mediated by norepinephrine, rather than dopamine, that the site of action of the norepinephrine is central, above the median eminence and inside the "blood-brain barrier", and that the norepinephrine acts via alpha-adrenergic receptors.	Norepinephrine	203-217	somatotropin	Canis lupus familiaris	75-89
186790-2	1976	The concentrations by bioassay of nerve growth factor in both epinephrine- and norepinephrine-induced saliva (3400 and 900 mug/ml, respectively) are higher than reported in any other source.	Norepinephrine	79-93	nerve growth factor	Mus musculus	34-53
186790-4	1976	The specific activity of the salivary nerve growth factor was 41, 36, 2, and 0.6 mug/mg of protein in secretions elicited by epinephrine, norepinephrine, pilocarpine, and isoproterenol, respectively.	Norepinephrine	138-152	nerve growth factor	Mus musculus	38-57
185109-0	1976	Additive effects of norepinephrine and cyclic AMP on the activation of the protein kinase from adipose tissue.	Norepinephrine	20-34	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	75-89
185109-4	1976	Wtih intact tissue, norepinephrine not only stimulates the protein kinase activity measured without exogenous cyclic AMP but also the total activity measured in the presence of cyclic AMP (5 X 10(-6) M); thus the effect of norepinephrine, obtained during incubation of the tissue, and that of cyclic AMP, added to the soluble fraction after incubation, were additive.	Norepinephrine	20-34	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	59-73
185109-9	1976	These results suggest that the effects of norepinephrine on the protein kinase of the fat pads cannot be completely explained by the model of Brostrom and colleagues.	Norepinephrine	42-56	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	64-78
1023189-3	1976	Noradrenaline (1--2 Mg/kg/min) produced the contrary changes in the renin secretion and diuresis, this being associated with a different activity of catecholamines in respect to tha alpha- and beta-adrenoreceptors.	Norepinephrine	0-13	renin	Canis lupus familiaris	68-73
933208-1	1976	The effect of the chronic administration of alpha-MSH on the incorporation of tritiated tyrosine into noradrenalin and dopamine and of tritiated tryptophan into serotonin was studied in different regions of the rat brain.	Norepinephrine	102-114	proopiomelanocortin	Rattus norvegicus	44-53
1265094-3	1976	In the present study driven atrial strips removed from stressed male CSF rats were found to exhibit an enhanced sensitivity to both norepinephrine and epinephrine.	Norepinephrine	132-146	colony stimulating factor 2	Rattus norvegicus	69-72
1186497-1	1975	The effect of somatostatin, on the secretion of noradrenaline and adrenaline was studied in eight normal subjects during exercise and in insulin induced hypoglycemia.	Norepinephrine	48-61	somatostatin	Homo sapiens	14-26
8786529-2	1996	We studied several histamine homologues as potential ligands for the histamine H3 receptor in two binding assays ([125l]iodophenpropit and N alpha-[3H]methylhistamine binding to rat brain cortex membranes) and two functional H3 receptor models (inhibition of the neurogenic contraction in the guinea pig jejunum and of [3H]noradrenaline release in mouse brain cortex slices).	Norepinephrine	323-336	histamine receptor H3	Rattus norvegicus	69-90
1186497-3	1975	Plasma noradrenaline during exercise tended to be lower during the infusion of somatostatin but the difference was not significant.	Norepinephrine	7-20	somatostatin	Homo sapiens	79-91
1153091-0	1975	The effect of ketamine HC1 on the in vitro metabolism of norepinephrine in rat cerebral cortex tissue.	Norepinephrine	57-71	Hypercalciuria QTL 1	Rattus norvegicus	23-26
9053798-1	1996	Norepinephrine-containing fibres in the medial prefrontal cortex derive from the locus coeruleus, a brainstem nucleus which also receives a dense innervation of enkephalin-immunoreactive axon terminals.	Norepinephrine	0-14	proenkephalin	Rattus norvegicus	161-171
805673-5	1975	Endogenous prostaglandin E-2 production contributes to the regulation of blood pressure by (1) opposing the vasoconstrictor and antidiuretic actions of circulating pressor hormones; (2) braking the release of norepinephrine from vasoconstrictor nerves; and (3) participating in the control extracellular fluid volume through its renal hemodynamic actions.	Norepinephrine	209-223	cystatin 12, pseudogene	Homo sapiens	25-28
9011768-1	1996	Dopamine beta-hydroxylase catalyzes the final step in noradrenaline synthesis and is expressed exclusively in noradrenergic and adrenergic cells.	Norepinephrine	54-67	dopamine beta-hydroxylase	Rattus norvegicus	0-25
8558260-0	1996	Vasoactive intestinal peptide, pituitary adenylate cyclase-activating peptide, and noradrenaline induce the transcription factors CCAAT/enhancer binding protein (C/EBP)-beta and C/EBP delta in mouse cortical astrocytes: involvement in cAMP-regulated glycogen metabolism.	Norepinephrine	83-96	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	162-173
165982-5	1975	On the one hand, insulin action (glucose transport) is inhibited by compounds (cholera toxin, ACTH, glucagon and L-norepinephrine) that stimulate adenylate cyclase; conversely, insulin both inhibits the lipolytic action of these compounds, and raises cellular levels of cyclic GMP.	Norepinephrine	113-129	5'-nucleotidase, cytosolic II	Homo sapiens	277-280
8551341-0	1996	Excitatory actions of norepinephrine on multiple classes of hippocampal CA1 interneurons.	Norepinephrine	22-36	carbonic anhydrase 1	Rattus norvegicus	72-75
8551341-1	1996	Norepinephrine (NE) causes an increase in the frequency of inhibitory postsynaptic potentials in CA1 pyramidal neurons in vitro.	Norepinephrine	0-14	carbonic anhydrase 1	Rattus norvegicus	97-100
237167-0	1975	Inhibitory action of norepinephrine on the induction of tryptophan-2,3-dioxygenase by cortisol: mediation by the alpha-receptor.	Norepinephrine	21-35	tryptophan 2,3-dioxygenase	Homo sapiens	56-82
8871132-5	1996	The NK-2 receptor agonist [beta Ala8]-NKA(4-10) (0.06 to 1 microgram/kg) also dose-dependently lowered blood pressure in the pithed guinea pig with noradrenaline-supported blood pressure, although it failed to do so in the same rat preparation.	Norepinephrine	148-161	substance-K receptor	Cavia porcellus	4-17
8746761-2	1996	Sympathetic nerve fibres, with their origin in the superior cervical ganglia, contain neuropeptide Y colocalized with norepinephrine.	Norepinephrine	118-132	neuropeptide Y	Homo sapiens	86-100
9112626-3	1996	This noncompetitive inhibitory effect of butobendin was stronger than the feed-back DBH inhibition by adrenaline and noradrenaline or by quinidine used as a standard antiarrhythmic compound.	Norepinephrine	117-130	dopamine beta-hydroxylase	Homo sapiens	84-87
8597392-3	1995	Norepinephrine (NE) potently stimulates CRH neurons in the PVN; however, the physiologic role of NE in stress-induced activation of the HPA is unknown.	Norepinephrine	0-14	corticotropin releasing hormone	Homo sapiens	40-43
4371328-0	1974	An ontogenic study on the effect of catecholamine receptor-stimulating agents on the turnover of noradrenaline and dopamine in the brain.	Norepinephrine	97-110	adrenoceptor beta 2	Homo sapiens	36-58
4766218-4	1973	Elastin binds the (-)-isomer of adrenaline and noradrenaline to twice the extent of the (+)-isomer.3.	Norepinephrine	47-60	elastin	Rattus norvegicus	0-7
8529333-2	1995	Human neuropeptide Y is an endogenous vasoconstrictor peptide that is costored with norepinephrine in sympathetic nerve endings and coreleased with the catecholamine under various physiologic and pathologic conditions.	Norepinephrine	84-98	neuropeptide Y	Homo sapiens	6-20
4766218-10	1973	The results of the study suggest that in tissues with a high content of collagen and elastin, binding to extracellular sites is the major mechanism for terminating the response to noradrenaline or to adrenergic nerve stimulation.	Norepinephrine	180-193	elastin	Rattus norvegicus	85-92
5279472-0	1971	Changes in activity of choline acetylase in central nervous system of rat after intraventricular administration of noradrenaline.	Norepinephrine	115-128	choline O-acetyltransferase	Rattus norvegicus	23-40
5262991-0	1969	Brain norepinephrine: evidence that neuronal release is essential for sham rage behavior following brainstem transection in cat.	Norepinephrine	6-20	long intergenic non-protein coding RNA 914	Homo sapiens	75-79
5262991-1	1969	There is a direct relationship between the magnitude of sham rage produced by brainstem transection in cat and the decrease of brainstem norepinephrine.	Norepinephrine	137-151	long intergenic non-protein coding RNA 914	Homo sapiens	61-65
5262991-2	1969	The attacks of rage are augmented by protriptyline and inhibited by haloperidol, drugs respectively facilitating or depressing the action of norepinephrine centrally.	Norepinephrine	141-155	long intergenic non-protein coding RNA 914	Homo sapiens	15-19
5642626-0	1968	[Analysis of the "biologic response" relationship for the action of oxytocin and noradrenaline on the skin and bladder of the frog].	Norepinephrine	81-94	oxytocin/neurophysin I prepropeptide	Homo sapiens	68-76
17772081-1	1963	Infusion of angiotensin or renin in small quantities affects the sympathetic nervous system so that responses are increased to either drugs or reflexes that cause release of norepinephrine at nerve endings.	Norepinephrine	174-188	renin	Canis lupus familiaris	27-32
33751565-6	2021	In vitro, the treatments of MDSCs with epinephrine (EPI) and norepinephrine (NE) but not corticosterone (CORT) treated H22 conditioned medium obviously inhibited T cell proliferation, as well as enhanced CXCR2 expression and Erk phosphorylation.	Norepinephrine	61-75	chemokine (C-X-C motif) receptor 2	Mus musculus	204-209
33580322-2	2021	Hindbrain noradrenergic neurons innervate the VMN, where norepinephrine regulates nNOS and GAD expression.	Norepinephrine	57-71	glutamate decarboxylase 1	Homo sapiens	91-94
33911125-2	2021	In this study, acute administration of the glucagon-like peptide-1 receptor agonist (GLP-1RA) liraglutide to mice increased the cecal levels of caseinolytic protease B, a component of Escherichia coli, and of norepinephrine.	Norepinephrine	209-223	glucagon-like peptide 1 receptor	Mus musculus	43-75
33402011-7	2021	Remarkably, endogenous beta2-adrenergic receptor/ADRB2 dynamic mass redistribution functional responses to norepinephrine were significantly decreased following CHX treatment, with a time course equivalent to that observed with the SNAP-ADRB2 degradation assay.	Norepinephrine	107-121	adrenoceptor beta 2	Homo sapiens	23-48
7479983-1	1995	Previous research indicates that norepinephrine and dopamine stimulate release of luteinizing hormone (LH)-releasing hormone (LHRH), which then reaches the adenohypophysis via the hypophyseal portal vessels to release LH.	Norepinephrine	33-47	gonadotropin releasing hormone 1	Rattus norvegicus	82-124
7479983-1	1995	Previous research indicates that norepinephrine and dopamine stimulate release of luteinizing hormone (LH)-releasing hormone (LHRH), which then reaches the adenohypophysis via the hypophyseal portal vessels to release LH.	Norepinephrine	33-47	gonadotropin releasing hormone 1	Rattus norvegicus	126-130
7486151-11	1995	In contrast, affected limbs of NP2 rats had a reduced arteriovenous increment in norepinephrine concentrations, compared to that in the control side (P &lt; 0.05).	Norepinephrine	81-95	neuronal pentraxin 2	Rattus norvegicus	31-34
33402011-7	2021	Remarkably, endogenous beta2-adrenergic receptor/ADRB2 dynamic mass redistribution functional responses to norepinephrine were significantly decreased following CHX treatment, with a time course equivalent to that observed with the SNAP-ADRB2 degradation assay.	Norepinephrine	107-121	adrenoceptor beta 2	Homo sapiens	49-54
33402011-7	2021	Remarkably, endogenous beta2-adrenergic receptor/ADRB2 dynamic mass redistribution functional responses to norepinephrine were significantly decreased following CHX treatment, with a time course equivalent to that observed with the SNAP-ADRB2 degradation assay.	Norepinephrine	107-121	adrenoceptor beta 2	Homo sapiens	237-242
33855088-4	2021	Results: The norepinephrine levels were markedly high in gastric cancer tissue, while the norepinephrine-degrading enzymes MAOA and MAOB showed low expression.	Norepinephrine	90-104	monoamine oxidase B	Homo sapiens	132-136
33855088-8	2021	The norepinephrine-degrading enzymes MAOA and MAOB have significant expression differences in cancer and normal tissue, and their missing or low expression may predict immune therapy outcomes for gastric cancer patients.	Norepinephrine	4-18	monoamine oxidase B	Homo sapiens	46-50
33665818-0	2021	Downregulation of connexin43 potentiates noradrenaline-induced expression of brain-derived neurotrophic factor in primary cultured cortical astrocytes.	Norepinephrine	41-54	brain derived neurotrophic factor	Homo sapiens	77-110
33665818-8	2021	Knockdown of Cx43 potentiated noradrenaline (NA)-induced expression of BDNF mRNA in cultured astrocytes.	Norepinephrine	30-43	brain derived neurotrophic factor	Homo sapiens	71-75
33367607-5	2021	Repeated exposure to norepinephrine or salbutamol suppressed both the glucagon and epinephrine responses to hypoglycemia compared to controls.	Norepinephrine	21-35	glucagon	Rattus norvegicus	70-78
33434145-8	2021	In vitro, 10 microM norepinephrine markedly downregulated the expressions of prolactin, IGFBP1, and PLZF, which are the specifical markers of decidual stromal cells during decidualization.	Norepinephrine	20-34	prolactin	Mus musculus	77-86
33443233-2	2020	The fight-or-flight response induces the release of the stress response hormone norepinephrine to stimulate beta-adrenergic receptors, cAMP production, and protein kinase A activity to augment Ca2+ influx through Cav1.2 and, consequently, cardiomyocyte contractility.	Norepinephrine	80-94	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	213-219
33165197-8	2020	Our results suggest that norepinephrine activation of beta-adrenoceptors in the hippocampal dentate gyrus is involved in spatial learning and memory enhancement induced by CRS in aged rats, in part via modulations of synaptic efficiency and CREB-BDNF signaling pathway.	Norepinephrine	25-39	brain-derived neurotrophic factor	Rattus norvegicus	246-250
8565052-0	1995	Norepinephrine-induced phosphorylation of the transcription factor CREB in isolated rat pinealocytes: an immunocytochemical study.	Norepinephrine	0-14	cAMP responsive element binding protein 1	Rattus norvegicus	67-71
8565052-3	1995	Treatment with norepinephrine or beta-adrenergic agonists resulted in a similar, time-dependent induction of p-CREB immunoreactivity, exclusively found in cell nuclei.	Norepinephrine	15-29	cAMP responsive element binding protein 1	Rattus norvegicus	111-115
8565052-8	1995	The results show that norepinephrine stimulation induces p-CREB immunoreactivity by acting upon beta-adrenergic receptors in virtually all rat pinealocytes.	Norepinephrine	22-36	cAMP responsive element binding protein 1	Rattus norvegicus	59-63
8645567-4	1995	Besides stimulating the acute thermogenic processes, norepinephrine can induce the expression of tissue-specific proteins such as the uncoupling protein, induce expression of non-tissue specific proteins necessary of the thermogenic processes (e.g. lipoprotein lipase) and repress the expression of non-essential proteins (e.g. subunit c of the ATP-synthase).	Norepinephrine	53-67	lipoprotein lipase	Homo sapiens	249-267
33075480-1	2020	The selective norepinephrine (NE) alpha2A-adrenoceptor (alpha2A-AR) agonist, guanfacine (Intuniv ), is FDA-approved for treating Attention Deficit Hyperactivity Disorder (ADHD) based on research in animals, a translational success story.	Norepinephrine	14-28	adrenoceptor alpha 2A	Homo sapiens	34-54
33075480-1	2020	The selective norepinephrine (NE) alpha2A-adrenoceptor (alpha2A-AR) agonist, guanfacine (Intuniv ), is FDA-approved for treating Attention Deficit Hyperactivity Disorder (ADHD) based on research in animals, a translational success story.	Norepinephrine	14-28	adrenoceptor alpha 2A	Homo sapiens	56-66
32948909-8	2020	Pharmacologic strategies include abrogating the beta2-adrenergic receptor signaling pathway to antagonize epinephrine and norepinephrine action on tumor and immune cells.	Norepinephrine	122-136	adrenoceptor beta 2	Homo sapiens	48-73
32942081-1	2020	Monoamine oxidases (MAO-A and MAO-B) are mammalian flavoenzyme, which catalyze the oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine, serotonin, and some other amines.	Norepinephrine	139-153	monoamine oxidase B	Homo sapiens	30-35
32981364-10	2020	Collectively, our findings support the existence of a norepinephrine-activated alpha1-adrenoceptor gated pathway that relies on WNK/SPAK/OxSR1 signaling to regulate NCC activity in SSH.	Norepinephrine	54-68	serine threonine kinase 39	Rattus norvegicus	132-136
32668300-3	2020	We previously identified an essential role of the molecular scaffold 14-3-3zeta in adipogenesis, but one of the earliest, identified functions of 14-3-3zeta is its regulatory effects on the activity of tyrosine hydroxylase, the rate-limiting enzyme in the synthesis of norepinephrine.	Norepinephrine	269-283	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	Mus musculus	146-156
8521164-16	1995	Furthermore, as the beta 3-adrenoceptor activity correlates to the norepinephrine activity, more pronounced effects will be expected in catecholamine sensitive subjects.	Norepinephrine	67-81	adrenoceptor beta 3	Homo sapiens	20-39
8748207-5	1995	Neuropeptide Y potentiated the mitogenic effect of noradrenaline, and together with adenosine 5"-triphosphate, the sympathetic cotransmitters reached a mitogenic effect of approximately 20% of fetal calf serum.	Norepinephrine	51-64	neuropeptide Y	Homo sapiens	0-14
33020652-4	2020	Intrathecal norepinephrine induced mechanical pain hypersensitivity via alpha1A-ARs in Hes5+ astrocytes, and chemogenetic stimulation of Hes5+ SDH astrocytes was sufficient to produce the hypersensitivity.	Norepinephrine	12-26	hes family bHLH transcription factor 5	Homo sapiens	87-91
7616202-2	1995	We previously generated transgenic mice expressing phenylethanolamine N-methyltransferase (PNMT) under the control of a human dopamine beta-hydroxylase gene promoter to switch catecholamine specificity from the norepinephrine phenotype to the epinephrine phenotype.	Norepinephrine	211-225	dopamine beta-hydroxylase	Homo sapiens	126-151
7616203-3	1995	In situ, the cDNA hybridizes specifically within norepinephrine-secreting cells, but in neither dopamine nor serotonin neurons, suggesting strongly it is a partial rat norepinephrine transporter cDNA.	Norepinephrine	49-63	solute carrier family 6 member 2	Rattus norvegicus	168-194
33020652-4	2020	Intrathecal norepinephrine induced mechanical pain hypersensitivity via alpha1A-ARs in Hes5+ astrocytes, and chemogenetic stimulation of Hes5+ SDH astrocytes was sufficient to produce the hypersensitivity.	Norepinephrine	12-26	hes family bHLH transcription factor 5	Homo sapiens	137-141
7612024-1	1995	We examined the effect of antiserum against HPC-1/Syntaxin-1A on the norepinephrine release from digitonin-permeabilized PC12h cells.	Norepinephrine	69-83	syntaxin 1A	Rattus norvegicus	50-61
32520577-5	2020	The relationship between the norepinephrine infusion rate and the use of beta-blockers and plasma cytokines was assessed in 195 patients with septic shock.Measurements and Main Results: Norepinephrine attenuated the production of proinflammatory mediators and reactive oxygen species and augmented antiinflammatory IL-10 production both in vitro and in LPS-challenged mice.	Norepinephrine	186-200	interleukin 10	Homo sapiens	315-320
7543257-4	1995	With norepinephrine, serotonin, prostaglandin F2 alpha, and K+, Cao from 0.025 to 0.8 mM induced a graded increase in Cai and active stress.	Norepinephrine	5-19	carbonic anhydrase 1	Rattus norvegicus	118-121
7792602-1	1995	Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family.	Norepinephrine	80-94	monoamine oxidase A	Homo sapiens	14-33
32702980-11	2020	Structural analysis revealed that inhibitor 3 binds to hPNMT by filling the catalytic binding pockets for the cofactor (SAM) and the substrate (norepinephrine) binding sites.	Norepinephrine	144-158	protein phosphatase 1 regulatory inhibitor subunit 11	Homo sapiens	34-45
7792602-1	1995	Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family.	Norepinephrine	80-94	monoamine oxidase A	Homo sapiens	35-39
32335195-6	2020	Ang-(1-7) (0.3 nmol in 2 microL) promoted the release of splenic norepinephrine and attenuated tumor necrosis factor (TNF) and nitric oxide (NO), but increased interleukin-10 (IL-10), levels in the serum, spleen, and liver in endotoxemic rats.	Norepinephrine	65-79	angiogenin	Rattus norvegicus	0-8
32335195-11	2020	Together, our results indicate that Ang-(1-7) regulates systemic inflammation and vascular hyporesponsiveness in endotoxemia via activation of a central Mas receptors/sympathetic circuits/norepinephrine axis and provide novel mechanistic insights into the anti-inflammatory Ang-(1-7) properties.	Norepinephrine	188-202	angiogenin	Rattus norvegicus	36-44
32406234-6	2020	Arrays of HD-CNTf rods microelectrode were applied to detect neurotransmitters i.e. dopamine (DA), serotonin (5-HT), epinephrine (Epn) and nor-epinephrine (Nor-epn) using voltammetric techniques.	Norepinephrine	139-154	ciliary neurotrophic factor	Homo sapiens	13-17
32485758-6	2021	However, norepinephrine-induced vasoconstriction was substantially higher in aortic rings in CAF-treated male mice.	Norepinephrine	9-23	caffeine susceptibility	Mus musculus	93-96
32157301-8	2020	ApoA-IV increased sympathetic activity assessed by norepinephrine turnover (NETO) rate in BAT and EWAT of chow-fed mice, whereas it elevated NETO only in EWAT of HFD-fed mice.	Norepinephrine	51-65	apolipoprotein A-IV	Mus musculus	0-7
32084491-2	2020	VMAT2 is present in the membrane of secretory vesicles and transports dopamine (DA), norepinephrine (NE), serotonin (5-HT), histamine, glutamate (Glu), and GABA into vesicles for presynaptic release.	Norepinephrine	85-99	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	0-5
32098331-11	2020	This study also highlights the first association between ADRbeta2 signalling and LYPD3; its knockdown significantly reduced the basal and norepinephrine-induced activity of MCF-7 cells in vitro.	Norepinephrine	138-152	adrenoceptor alpha 2A	Homo sapiens	57-65
32140623-3	2020	Inhibition of SGLT2 prevented weight gain, reduced blood pressure, significantly reduced elevations of tyrosine hydroxylase and norepinephrine, and protects against endothelial dysfunction.	Norepinephrine	128-142	solute carrier family 5 (sodium/glucose cotransporter), member 2	Mus musculus	14-19
31941827-3	2020	Our results show that Abeta oligomers bind to an allosteric site on alpha2A adrenergic receptor (alpha2AAR) to redirect norepinephrine-elicited signaling to glycogen synthase kinase 3beta (GSK3beta) activation and tau hyperphosphorylation.	Norepinephrine	120-134	adrenoceptor alpha 2A	Homo sapiens	68-95
31941827-3	2020	Our results show that Abeta oligomers bind to an allosteric site on alpha2A adrenergic receptor (alpha2AAR) to redirect norepinephrine-elicited signaling to glycogen synthase kinase 3beta (GSK3beta) activation and tau hyperphosphorylation.	Norepinephrine	120-134	adrenoceptor alpha 2A	Homo sapiens	97-106
31793911-0	2020	Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus.	Norepinephrine	0-14	legumain	Homo sapiens	44-47
31813250-8	2020	Suggesting a critical role of IL-17A in Paneth cell-mediated release of norepinephrine, recombinant IL-17A induces norepinephrine release in small intestine of mice.	Norepinephrine	72-86	interleukin 17A	Mus musculus	30-36
31813250-8	2020	Suggesting a critical role of IL-17A in Paneth cell-mediated release of norepinephrine, recombinant IL-17A induces norepinephrine release in small intestine of mice.	Norepinephrine	72-86	interleukin 17A	Mus musculus	100-106
31813250-8	2020	Suggesting a critical role of IL-17A in Paneth cell-mediated release of norepinephrine, recombinant IL-17A induces norepinephrine release in small intestine of mice.	Norepinephrine	115-129	interleukin 17A	Mus musculus	100-106
31747589-2	2019	We find that ASL is prominently expressed in the nucleus locus coeruleus (LC), the central source of norepinephrine.	Norepinephrine	101-115	argininosuccinate lyase	Mus musculus	13-16
31649525-0	2019	Alpha1-Adrenergic Receptor Mediated Long-Term Depression at CA3-CA1 Synapses Can Be Induced via Accumulation of Endogenous Norepinephrine and Is Preserved Following Noradrenergic Denervation.	Norepinephrine	123-137	carbonic anhydrase 3	Rattus norvegicus	60-67
31325464-0	2019	Sites phosphorylated in human alpha1B-adrenoceptors in response to noradrenaline and phorbol myristate acetate.	Norepinephrine	67-80	alpha-1-B glycoprotein	Homo sapiens	30-37
31322231-3	2019	However, limited evidence of TPH alteration has been found in selective serotonin and noradrenaline reuptake inhibitors (SNRIs), and more key enzymes need to be investigated.	Norepinephrine	86-99	tryptophan hydroxylase 1	Rattus norvegicus	29-32
31248037-0	2019	Norepinephrine Inhibits Synovial Adipose Stem Cell Chondrogenesis via alpha2a-Adrenoceptor-Mediated ERK1/2 Activation.	Norepinephrine	0-14	adrenoceptor alpha 2A	Homo sapiens	70-90
30920175-10	2019	CONCLUSIONS: The association of ENaC, Na-K-ATPase, and SGK1 expression with the cord blood norepinephrine concentration points to the importance of birth stress in promoting lung fluid clearance during early postnatal pulmonary adaptation.	Norepinephrine	91-105	serum/glucocorticoid regulated kinase 1	Homo sapiens	55-59
7617129-6	1995	Noradrenaline (NA) triggered CRH release in a dose-dependent (1-20 microM) and time-dependent (0.5-6 h) manner.	Norepinephrine	0-13	corticotropin releasing hormone	Homo sapiens	29-32
7724578-14	1995	Previous results have indicated that norepinephrine stimulates release of NO from the NOergic neurons, which then stimulates the release of LHRH.	Norepinephrine	37-51	gonadotropin releasing hormone 1	Rattus norvegicus	140-144
7617706-2	1995	The female TGF alpha mice showed elevated levels of norepinephrine (NE) in the hypothalamus and serotonin (5-HT) in the cortex and brain stem when compared with nontransgenic CD-1 females.	Norepinephrine	52-66	transforming growth factor alpha	Mus musculus	11-20
31021732-2	2019	We have previously shown that the mandated housing temperature for laboratory mice (~22 C) induces mild, but chronic, cold stress resulting in increased circulating norepinephrine, which binds to, and triggers activation of, beta-adrenergic receptors (beta-AR) on tumor and immune cells.	Norepinephrine	165-179	adrenergic receptor, beta 1	Mus musculus	225-250
31021732-2	2019	We have previously shown that the mandated housing temperature for laboratory mice (~22 C) induces mild, but chronic, cold stress resulting in increased circulating norepinephrine, which binds to, and triggers activation of, beta-adrenergic receptors (beta-AR) on tumor and immune cells.	Norepinephrine	165-179	adrenergic receptor, beta 1	Mus musculus	252-259
30930287-1	2019	Beta-adrenergic receptor (b-AR) activation by noradrenaline (NA) enhances memory formation and long-term potentiation (LTP), a form of synaptic plasticity characterized by an activity-dependent increase in synaptic strength.	Norepinephrine	46-59	adrenoceptor beta 2	Homo sapiens	0-24
30930287-1	2019	Beta-adrenergic receptor (b-AR) activation by noradrenaline (NA) enhances memory formation and long-term potentiation (LTP), a form of synaptic plasticity characterized by an activity-dependent increase in synaptic strength.	Norepinephrine	46-59	adrenoceptor beta 2	Homo sapiens	26-30
31657686-6	2019	RESULTS: Infusion of apelin into PVN of Wistar-Kyoto (WKY) rats induced chronic increases in systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), plasma norepinephrine (NE) level, maximal depressor response to hexamethonium (Hex), NAD(P)H oxidase activity, superoxide anions levels, and Nox4 expression.	Norepinephrine	193-207	apelin	Rattus norvegicus	21-27
7789743-1	1995	The activity of serotonin N-acetyltransferase in the rat pineal is regulated through a synergistic action of norepinephrine on alpha 1- and beta 1-adrenoceptors.	Norepinephrine	109-123	aralkylamine N-acetyltransferase	Rattus norvegicus	16-45
30571558-3	2019	Application of norepinephrine increased the basolateral 40 pS K+ channel (Kir4.1/Kir5.1 heterotetramer) in the DCT.	Norepinephrine	15-29	potassium inwardly-rectifying channel, subfamily J, member 16	Mus musculus	81-87
7648607-8	1995	There is a concomitant increase in excitatory inputs, mainly noradrenaline, excitatory amino acids, and NPY, which increase the synthesis and release of GnRH at the beginning of the juvenile period and participate in the coupling of GnRH neural activity to the ongoing rhythmic activity of a hypothalamic circadian oscillator.	Norepinephrine	61-74	gonadotropin releasing hormone 1	Rattus norvegicus	153-157
7648607-8	1995	There is a concomitant increase in excitatory inputs, mainly noradrenaline, excitatory amino acids, and NPY, which increase the synthesis and release of GnRH at the beginning of the juvenile period and participate in the coupling of GnRH neural activity to the ongoing rhythmic activity of a hypothalamic circadian oscillator.	Norepinephrine	61-74	gonadotropin releasing hormone 1	Rattus norvegicus	233-237
30341172-4	2018	Dopamine is converted to norepinephrine by dopamine-beta-hydroxylase (DBH), which acquires its essential Cu cofactor from ATP7A.	Norepinephrine	25-39	ATPase copper transporting alpha	Homo sapiens	122-127
30619611-1	2019	alpha1A- and alpha1B-adrenoceptors (ARs) are G protein-coupled receptors (GPCRs) that are activated by adrenaline and noradrenaline to modulate smooth muscle contraction in the periphery, and neuronal outputs in the central nervous system (CNS).	Norepinephrine	118-131	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	0-7
7823957-6	1995	Glutamate, norepinephrine, and bradykinin elicited phosphorylation of p51 in cultures of primary rat type 1 astrocytes.	Norepinephrine	11-25	tumor protein p63	Homo sapiens	70-73
7775405-3	1995	Continuous administration of noradrenaline or isoproterenol (beta-agonist) for 10 days resulted in increased synthesis of the mitochondrial uncoupling protein and an isoform of glucose transporter (GLUT4), and tissue hyperplasia, in the same way as after cold exposure of the same duration.	Norepinephrine	29-42	solute carrier family 2 member 4	Rattus norvegicus	198-203
7798950-1	1995	Dopamine beta-hydroxylase (DBH) catalyzes the synthesis of the neurohormone norepinephrine and is expressed only in noradrenergic and adrenergic cells of the nervous and endocrine systems.	Norepinephrine	76-90	dopamine beta-hydroxylase	Rattus norvegicus	0-25
7798950-1	1995	Dopamine beta-hydroxylase (DBH) catalyzes the synthesis of the neurohormone norepinephrine and is expressed only in noradrenergic and adrenergic cells of the nervous and endocrine systems.	Norepinephrine	76-90	dopamine beta-hydroxylase	Rattus norvegicus	27-30
8788067-1	1995	GTP cyclohydrolase I (GCH) is the first and rate-limiting enzyme for the biosynthesis of tetrahydrobiopterin (BH4), the cofactor of phenylalanine, tyrosine, and tryptophan hydroxylases, the enzymes that synthesize tyrosine, catecholamines (dopamine, noradrenaline, and adrenaline), and serotonin, respectively.	Norepinephrine	250-263	GTP cyclohydrolase 1	Mus musculus	0-20
8788067-1	1995	GTP cyclohydrolase I (GCH) is the first and rate-limiting enzyme for the biosynthesis of tetrahydrobiopterin (BH4), the cofactor of phenylalanine, tyrosine, and tryptophan hydroxylases, the enzymes that synthesize tyrosine, catecholamines (dopamine, noradrenaline, and adrenaline), and serotonin, respectively.	Norepinephrine	250-263	GTP cyclohydrolase 1	Mus musculus	22-25
8788067-4	1995	Using this antibody specific for GCH, we observed strong GCH immunostaining in the liver cells, in the dopamine-, noradrenaline-, adrenaline-, or serotonin-containing cells of the brain, and in the adrenal gland of mice.	Norepinephrine	114-127	GTP cyclohydrolase 1	Mus musculus	33-36
8584674-1	1995	Monoamine oxidase (MAO) A (EC 1.4.3.4) oxidizes norepinephrine and serotonin and is expressed in a cell type-specific manner.	Norepinephrine	48-62	monoamine oxidase A	Homo sapiens	0-25
7695023-4	1994	In early withdrawal, there was a significant positive correlation between CSF norepinephrine (NE) and corticotropin releasing hormone (CRH) concentrations (r = 0.95, p &lt; 0.001).	Norepinephrine	78-92	corticotropin releasing hormone	Homo sapiens	135-138
7874313-5	1994	The [3H]noradrenaline release evoked by NMDA (100 microM)+gp120 (100 pM) was prevented by classical NMDA receptor antagonists, as well as by 10 microM memantine.	Norepinephrine	8-21	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	58-63
29476941-0	2018	Postoperative serum levels of Endocan are associated with the duration of norepinephrine support after coronary artery bypass surgery.	Norepinephrine	74-88	endothelial cell specific molecule 1	Homo sapiens	30-37
29476941-12	2018	The norepinephrine support increases the risk of Endocan release, suggesting a relationship between the kinetic of Endocan and the vasoplegic syndrome.	Norepinephrine	4-18	endothelial cell specific molecule 1	Homo sapiens	49-56
29476941-12	2018	The norepinephrine support increases the risk of Endocan release, suggesting a relationship between the kinetic of Endocan and the vasoplegic syndrome.	Norepinephrine	4-18	endothelial cell specific molecule 1	Homo sapiens	115-122
30209240-5	2018	Both CNTF and secretagogin ablation occlude stress-induced cortical norepinephrine synthesis, ensuing neuronal excitation and behavioral stereotypes.	Norepinephrine	68-82	ciliary neurotrophic factor	Homo sapiens	5-9
30341696-1	2018	In early 1920s, tyramine oxidase was discovered that metabolized tyramine and in 1933 Blaschko demonstrated that this enzyme also metabolized adrenaline, noradrenaline and dopamine.	Norepinephrine	154-167	monoamine oxidase B	Homo sapiens	16-32
30037827-8	2018	The spatial structure of both fluctuation patterns resembled the spatial distribution of the expression of catecholamine receptor genes: alpha1 norepinephrine receptors (for the fluctuation pattern: placebo > atomoxetine), D2-like dopamine receptors (pattern: atomoxetine > placebo), and beta norepinephrine receptors (for both patterns, with correlations of opposite sign).	Norepinephrine	144-158	adrenoceptor beta 2	Homo sapiens	107-129
30037827-8	2018	The spatial structure of both fluctuation patterns resembled the spatial distribution of the expression of catecholamine receptor genes: alpha1 norepinephrine receptors (for the fluctuation pattern: placebo > atomoxetine), D2-like dopamine receptors (pattern: atomoxetine > placebo), and beta norepinephrine receptors (for both patterns, with correlations of opposite sign).	Norepinephrine	293-307	adrenoceptor beta 2	Homo sapiens	107-129
29738736-4	2018	One such GR-independent mechanism involves corticosteroid-induced inhibition of monoamine transport mediated by "uptake2" transporters, including organic cation transporter 3 (OCT3), a low-affinity, high-capacity transporter for norepinephrine, epinephrine, dopamine, serotonin and histamine.	Norepinephrine	229-243	OCTN3	Homo sapiens	146-174
29738736-4	2018	One such GR-independent mechanism involves corticosteroid-induced inhibition of monoamine transport mediated by "uptake2" transporters, including organic cation transporter 3 (OCT3), a low-affinity, high-capacity transporter for norepinephrine, epinephrine, dopamine, serotonin and histamine.	Norepinephrine	229-243	OCTN3	Homo sapiens	176-180
29377263-4	2018	In the present study, we investigated the effects of adrenaline (AD) and norepinephrine (NE) on hepatic hepcidin regulation.	Norepinephrine	73-87	hepcidin antimicrobial peptide	Mus musculus	104-112
29555480-7	2018	Moreover, we also found that CORT levels in serum were significantly increased, along with the decrease of brain-derived neurotrophic factor (BDNF) mRNA, BDNF protein, 5-hydroxytryptamine (5-HT) and norepinephrine (NE) levels in the hippocampus.	Norepinephrine	199-213	cortistatin	Mus musculus	29-33
8039596-11	1994	In contrast to their action in the mesenteric artery, insulin (exceeding 100 nM) and IGF-I (1-30 nM) attenuated AVP- and norepinephrine-induced contraction in rat aortic rings.	Norepinephrine	121-135	insulin-like growth factor 1	Rattus norvegicus	85-90
7990977-2	1994	Local infusions of NPY had no measurable effect on venous tone, but coinfusion of a constant high dose of NPY (242 pmol/min) with noradrenaline caused a 2.9-fold increase in the mean ED50 for noradrenaline.	Norepinephrine	130-143	neuropeptide Y	Homo sapiens	106-109
7990977-2	1994	Local infusions of NPY had no measurable effect on venous tone, but coinfusion of a constant high dose of NPY (242 pmol/min) with noradrenaline caused a 2.9-fold increase in the mean ED50 for noradrenaline.	Norepinephrine	192-205	neuropeptide Y	Homo sapiens	106-109
7990977-5	1994	Although functional interactions between NPY or VIP and noradrenaline could be demonstrated, the dosages of the peptides required were high.	Norepinephrine	56-69	neuropeptide Y	Homo sapiens	41-44
7921609-14	1994	Nitric oxide gas in solution (0.2-2.2 microM; NOg) relaxed artery segments precontracted with noradrenaline.	Norepinephrine	94-107	noggin	Rattus norvegicus	46-49
7994163-1	1994	The aim of this experiment was to measure the concentration of neuropeptide Y (NPY), a vasoactive transmitter which co-exists with noradrenaline in sympathetic nerve terminals, in venous blood taken from the painful and contralateral limbs of 16 patients with features of reflex sympathetic dystrophy (RSD) or causalgia.	Norepinephrine	131-144	neuropeptide Y	Homo sapiens	63-77
7994163-1	1994	The aim of this experiment was to measure the concentration of neuropeptide Y (NPY), a vasoactive transmitter which co-exists with noradrenaline in sympathetic nerve terminals, in venous blood taken from the painful and contralateral limbs of 16 patients with features of reflex sympathetic dystrophy (RSD) or causalgia.	Norepinephrine	131-144	neuropeptide Y	Homo sapiens	79-82
7949234-9	1994	We conclude that post norepinephrine induced hyperemia in the rat mesenteric circulation is modulated by alpha 2 and beta 2 adrenergic receptor activation, adenosine release, and endothelial factors.	Norepinephrine	22-36	adrenoceptor beta 2	Rattus norvegicus	105-143
8047545-2	1994	Both alkaloids relax, concentration dependently, the contractile response elicited by depolarizing solution (KCl 80 mM) or noradrenaline (1 microM).	Norepinephrine	123-136	neurogenin 3	Rattus norvegicus	15-20
8032664-3	1994	In the present work the P1 and P2Y purinoceptor antagonists, 8-phenyltheophylline and reactive blue 2, respectively, were used to study the mechanisms of relaxation responses induced by GTP, guanosine, adenosine 5"-triphosphate (ATP) and adenosine in noradrenaline-precontracted rat mesenteric artery rings.	Norepinephrine	251-264	perforin 1	Rattus norvegicus	24-47
29496635-8	2018	There was a significant increase in norepinephrine concentration in the SN of Pink1 -/- animals.	Norepinephrine	36-50	PTEN induced kinase 1	Rattus norvegicus	78-83
29524394-8	2018	Collectively, these findings provide useful information relevant to the differential metabolism of dopamine, epinephrine, norepinephrine and serotonin through sulfoconjugation in individuals having different SULT1A3/SULT1A4 genotypes.	Norepinephrine	122-136	sulfotransferase family 1A member 3	Homo sapiens	208-215
7935259-2	1994	Structurally related dithiocarbamates have been found to decrease norepinephrine (NE) synthesis by suppressing the activity of dopamine-beta-hydroxylase.	Norepinephrine	66-80	dopamine beta-hydroxylase	Rattus norvegicus	127-152
8032617-17	1994	However, surgical denervation of the rat kidney, resulting in more than 90% reduction in renal noradrenaline content, selectively reduced the beta 2-adrenoceptor population by 80%, implying the presence of beta 2-adrenoceptors on renal sympathetic nerve terminals.	Norepinephrine	95-108	adrenoceptor beta 2	Rattus norvegicus	142-161
7511093-4	1994	Treatment of GT1-1 cells with increasing concentrations of L-arginine, the direct precursor of NO, produced a marked reduction of norepinephrine-stimulated GnRH release despite a lack of effect on basal secretion.	Norepinephrine	130-144	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	13-16
8016410-0	1994	Neuropeptide Y stimulates proliferation of human vascular smooth muscle cells: cooperation with noradrenaline and ATP.	Norepinephrine	96-109	neuropeptide Y	Homo sapiens	0-14
7509126-4	1994	By including the interactions of paranoia subscale by CSF norepinephrine and anxiety by CSF norepinephrine, the model correctly identified 20 relapsers and 23 nonrelapsers with a sensitivity and specificity of 83% and 88%, respectively.	Norepinephrine	92-106	colony stimulating factor 2	Homo sapiens	88-91
8205750-10	1994	Arterial insulin as well as Adr and noradrenaline increased with the combined NPY-and Adr infusion as with Adr alone.	Norepinephrine	36-49	neuropeptide Y	Homo sapiens	78-81
8204564-4	1994	The drug attenuated the inhibitory action of PKC activator, TPA, on the noradrenergic response from alpha 1-adrenoceptor and the potentiating action of TPA on the cyclic AMP stimulated with noradrenaline and isoproterenol.	Norepinephrine	190-203	plasminogen activator, tissue type	Rattus norvegicus	60-63
8204564-4	1994	The drug attenuated the inhibitory action of PKC activator, TPA, on the noradrenergic response from alpha 1-adrenoceptor and the potentiating action of TPA on the cyclic AMP stimulated with noradrenaline and isoproterenol.	Norepinephrine	190-203	plasminogen activator, tissue type	Rattus norvegicus	152-155
8192837-1	1994	Immunoreactivity for Fos protein following 30 min of sensory and behavioral experience with foster pups was measured in different brain areas of nulliparous female Balb/c mice who were intact, ovariectomized, or selectively depleted of olfactory bulb noradrenaline.	Norepinephrine	251-264	FBJ osteosarcoma oncogene	Mus musculus	21-24
8192837-4	1994	Noradrenaline depletion of the olfactory bulb prevented Fos induction in primary olfactory areas, but not in the medial preoptic area, whereas distal exposure to pup cues enhanced Fos expression in the olfactory areas but not in the medial preoptic area.	Norepinephrine	0-13	FBJ osteosarcoma oncogene	Mus musculus	56-59
7909482-0	1994	Release of acetylcholine and noradrenaline from the cholinergic and adrenergic afferents in rat hippocampal CA1, CA3 and dentate gyrus regions.	Norepinephrine	29-42	carbonic anhydrase 1	Rattus norvegicus	108-111
8012897-4	1994	Plasma noradrenaline increased significantly at 1 week and increased further after 3 weeks of pacing (control, 202 +/- 16; 1 week, 528 +/- 62; 3 weeks, 750 +/- 139 pg.mL-1).	Norepinephrine	7-20	L1 cell adhesion molecule	Mus musculus	167-171
8372797-8	1993	The increase in the ejection fraction by these drugs and the decrease of plasma norepinephrine levels by ACE inhibitors may contribute to improved long-term survival.	Norepinephrine	80-94	angiotensin I converting enzyme	Canis lupus familiaris	105-108
8219410-12	1993	Collectively, the overlapping distribution of AChE+ and NA nerve profiles in spleen and parallel loss of both population of nerve fibers following surgical and chemical sympathectomy support the presence of AChE in NA nerves colocalized with norepinephrine, and thus make AChE+ staining an inappropriate marker for cholinergic innervation in the rat spleen.	Norepinephrine	242-256	acetylcholinesterase	Rattus norvegicus	207-211
8219410-12	1993	Collectively, the overlapping distribution of AChE+ and NA nerve profiles in spleen and parallel loss of both population of nerve fibers following surgical and chemical sympathectomy support the presence of AChE in NA nerves colocalized with norepinephrine, and thus make AChE+ staining an inappropriate marker for cholinergic innervation in the rat spleen.	Norepinephrine	242-256	acetylcholinesterase	Rattus norvegicus	207-211
8411814-15	1993	It is concluded that the decrease of MUP after phentolamine administration is due to the relaxation of periurethral part of external urethral sphincter, and clinical denervation supersensitivity of the external urethral sphincter after norepinephrine administration was not demonstrated in the PNI groups.	Norepinephrine	236-250	major urinary protein, pseudogene	Homo sapiens	37-40
7688735-1	1993	Dopamine beta-hydroxylase (DBH), the enzyme catalyzing the conversion of dopamine to norepinephrine, is specifically expressed in adrenergic and noradrenergic neurons in the central nervous system.	Norepinephrine	85-99	dopamine beta-hydroxylase	Homo sapiens	0-25
7688735-1	1993	Dopamine beta-hydroxylase (DBH), the enzyme catalyzing the conversion of dopamine to norepinephrine, is specifically expressed in adrenergic and noradrenergic neurons in the central nervous system.	Norepinephrine	85-99	dopamine beta-hydroxylase	Homo sapiens	27-30
8370239-1	1993	Neuropeptide Y (NPY) is a peptide released together with noradrenaline (NA) from sympathetic nerve endings.	Norepinephrine	57-70	neuropeptide Y	Homo sapiens	0-14
8370239-1	1993	Neuropeptide Y (NPY) is a peptide released together with noradrenaline (NA) from sympathetic nerve endings.	Norepinephrine	57-70	neuropeptide Y	Homo sapiens	16-19
8331563-1	1993	Normetanephrine (NMN) and metanephrine (MN) are produced by the actions of catechol-O-methyltransferase on norepinephrine (NE) and epinephrine (E).	Norepinephrine	107-121	catechol-O-methyltransferase	Rattus norvegicus	75-103
8509133-0	1993	Modulation of interferon-gamma-induced major histocompatibility complex class II and Fc receptor expression on isolated microglia by transforming growth factor-beta 1, interleukin-4, noradrenaline and glucocorticoids.	Norepinephrine	183-196	interferon gamma	Rattus norvegicus	14-30
8509133-7	1993	Non-cytokine mediators present during stimulation, such as noradrenaline, dexamethasone and corticosterone, are also potent inhibitors of IFN-gamma-induced activation of microglia and macrophages.	Norepinephrine	59-72	interferon gamma	Rattus norvegicus	138-147
8321627-0	1993	Disinhibition of AVP release during noradrenaline and angiotensin II infusions in dogs by maintaining normotension with sodium nitroprusside.	Norepinephrine	36-49	arginine vasopressin	Canis lupus familiaris	17-20
8318751-1	1993	Thiram has been reported to inhibit dopamine-beta-hydroxylase (D beta H), thereby affecting norepinephrine (NE) synthesis.	Norepinephrine	92-106	dopamine beta-hydroxylase	Rattus norvegicus	36-61
8440378-5	1993	Preconfluent cells in brown fat primary cultures responded to norepinephrine with a decrease in C/EBP alpha and an increase in C/EBP beta mRNA; in confluent cells the expression of both factors was increased.	Norepinephrine	62-76	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	127-137
1359011-2	1992	In this study we have found that in PC12 cells, the mRNA levels of dopamine beta-hydroxylase (DBH), the enzyme that catalyzes the formation of norepinephrine from dopamine, can be regulated by glucocorticoids and cyclic AMP (cAMP) analogues.	Norepinephrine	143-157	dopamine beta-hydroxylase	Rattus norvegicus	67-92
1359011-2	1992	In this study we have found that in PC12 cells, the mRNA levels of dopamine beta-hydroxylase (DBH), the enzyme that catalyzes the formation of norepinephrine from dopamine, can be regulated by glucocorticoids and cyclic AMP (cAMP) analogues.	Norepinephrine	143-157	dopamine beta-hydroxylase	Rattus norvegicus	94-97
1363791-5	1992	One possible explanation for this muscarinically mediated stimulation of GnRH release is that it results from cross-talk between the muscarinic and the alpha 1-adrenergic receptors, i.e., muscarinic agonists might inhibit the release induced by alpha 1-agonists, and muscarinic antagonists, by cancelling this inhibitory effect, might thus allow the endogenous alpha 1-agent, norepinephrine, to induce the release of GnRH.	Norepinephrine	376-390	gonadotropin releasing hormone 1	Rattus norvegicus	73-77
1280593-0	1992	Atrial natriuretic peptide suppresses renal vasoconstriction induced by angiotensin II and norepinephrine in dogs.	Norepinephrine	91-105	natriuretic peptide A	Canis lupus familiaris	0-26
1280593-1	1992	Atrial natriuretic peptide (ANP, 10 and 50 ng/kg per min), infused into the renal artery, suppressed decreases in renal blood flow induced by intrarenal arterial injection of angiotensin II (Ang II, 25-100 ng) and norepinephrine (NE, 0.25-1 microgram) in anesthetized dogs.	Norepinephrine	214-228	natriuretic peptide A	Canis lupus familiaris	0-26
1280593-1	1992	Atrial natriuretic peptide (ANP, 10 and 50 ng/kg per min), infused into the renal artery, suppressed decreases in renal blood flow induced by intrarenal arterial injection of angiotensin II (Ang II, 25-100 ng) and norepinephrine (NE, 0.25-1 microgram) in anesthetized dogs.	Norepinephrine	214-228	natriuretic peptide A	Canis lupus familiaris	28-31
1426125-0	1992	Brain norepinephrine reductions in soman-intoxicated rats: association with convulsions and AChE inhibition, time course, and relation to other monoamines.	Norepinephrine	6-20	acetylcholinesterase	Rattus norvegicus	92-96
1331754-4	1992	The endogenous catecholamines epinephrine (EPI) and norepinephrine (NE) were found to have low affinities (micromolar) for the beta 3AR of both species.	Norepinephrine	52-66	adrenoceptor beta 3	Homo sapiens	127-135
1415530-5	1992	Norepinephrine injections increased lipoprotein lipase mRNA levels in the tissue; this effect was mediated via a beta-adrenergic receptor.	Norepinephrine	0-14	lipase G, endothelial type	Rattus norvegicus	48-54
1354602-1	1992	The release of GnRH evoked by norepinephrine (NE) was studied in GT1 GnRH neuronal cell lines in superfusion and static cultures.	Norepinephrine	30-44	gonadotropin releasing hormone 1	Mus musculus	15-19
1354602-1	1992	The release of GnRH evoked by norepinephrine (NE) was studied in GT1 GnRH neuronal cell lines in superfusion and static cultures.	Norepinephrine	30-44	gonadotropin releasing hormone 1	Mus musculus	69-73
1356432-6	1992	These studies indicate that, in addition to the dopamine system, the norepinephrine and serotonin systems also play prominent roles in the activation of zif268 and c-fos by cocaine and amphetamine.	Norepinephrine	69-83	early growth response 1	Homo sapiens	153-159
1312014-4	1992	A 24 h pre-incubation with either CRH, epinephrine or nor-epinephrine increased the [125I]IL-1 alpha binding sites in the AtT-20 cells and conversely, a similar pre-incubation with either dexamethasone or tumour necrosis factor-alpha (TNF alpha) decreased them without affecting the affinity of the receptors in either case.	Norepinephrine	54-69	interleukin 1 alpha	Mus musculus	90-100
1577991-1	1992	Phenylethanolamine N-methyltransferase (PNMT), the final enzyme in the catecholamine biosynthetic pathway that converts norepinephrine to epinephrine, has been detected in the retinas of various vertebrate species.	Norepinephrine	120-134	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-38
1577991-1	1992	Phenylethanolamine N-methyltransferase (PNMT), the final enzyme in the catecholamine biosynthetic pathway that converts norepinephrine to epinephrine, has been detected in the retinas of various vertebrate species.	Norepinephrine	120-134	phenylethanolamine-N-methyltransferase	Rattus norvegicus	40-44
21554582-0	1992	Morphine but not Naloxone Enhances Luteinizing Hormone-Releasing Hormone Neuronal Responsiveness to Norepinephrine.	Norepinephrine	100-114	gonadotropin releasing hormone 1	Rattus norvegicus	35-72
1635895-3	1992	This reduced norepinephrine release may augment the fall in blood pressure induced by accumulated acetylcholine stimulating muscarinic receptors following cholinesterase inhibition.	Norepinephrine	13-27	butyrylcholinesterase	Homo sapiens	155-169
1493849-7	1992	The data also suggested the existence of a slower elimination phase, with a half life of 13 h. The venous plasma concentration of noradrenaline (NA) increased 3-fold within 15 min after the yohimbine injection while plasma adrenaline (A) and neuropeptide Y-like immunoreactivity (NPY-LI) remained unchanged.	Norepinephrine	130-143	neuropeptide Y	Homo sapiens	280-283
12106301-10	1992	Thus the present experiments suggest that the action of muscarinic agonists on IAHP cannot be explained by an effect on protein kinase C, but support a role for protein kinase A in mediating the action of noradrenalin.	Norepinephrine	205-217	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	161-177
1786546-1	1991	Noradrenaline-containing nerve terminals within the cat spinal dorsal horn were studied by immunocytochemical localization of dopamine-beta-hydroxylase.	Norepinephrine	0-13	dopamine beta-hydroxylase	Homo sapiens	126-151
1935790-11	1991	In vivo administration of prazosin blocked the effect of both noradrenaline and fasting on hepatic endothelial lipase activity in whole liver.	Norepinephrine	62-75	lipase G, endothelial type	Rattus norvegicus	99-117
1656768-4	1991	Reduction of pHi by sodium propionate reduced the norepinephrine-stimulated cGMP accumulation by 70%, and its effect on the ISO-stimulated cGMP response was stimulatory.	Norepinephrine	50-64	glucose-6-phosphate isomerase	Rattus norvegicus	13-16
1940021-3	1991	Subsequent inhibition of phenylethanolamine-N-methyltransferase (PNMT) allowed the gradual restoration of dopamine and noradrenaline but not adrenaline, resulting in a greater relative depletion of adrenaline.	Norepinephrine	119-132	phenylethanolamine-N-methyltransferase	Rattus norvegicus	25-63
1940021-3	1991	Subsequent inhibition of phenylethanolamine-N-methyltransferase (PNMT) allowed the gradual restoration of dopamine and noradrenaline but not adrenaline, resulting in a greater relative depletion of adrenaline.	Norepinephrine	119-132	phenylethanolamine-N-methyltransferase	Rattus norvegicus	65-69
2035576-6	1991	Neuropeptide Y (10(-7) mol/L) often, but not always, enhanced the contraction induced by noradrenaline (10(-6) mol/L).	Norepinephrine	89-102	neuropeptide Y	Homo sapiens	0-14
1645362-1	1991	Metabolic events stimulated by epinephrine and norepinephrine in hepatocytes isolated from fetal and early postnatal male rats are largely mediated through the beta 2-adrenergic receptor-/cyclic AMP dependent-system, whereas the same stimuli are transduced through the alpha 1-adrenergic receptor-/phosphatidylinositol dependent-system in hepatocytes isolated from young adult male rats.	Norepinephrine	47-61	adrenoceptor beta 2	Rattus norvegicus	160-186
19215520-9	1991	Using systems optimized to avoid technical artifacts, stimulation with naloxone demonstrated dose-dependent GnRH release in both systems whereas norepinephrine gave a clear dose-dependent GnRH release only in the static system.	Norepinephrine	145-159	gonadotropin releasing hormone 1	Rattus norvegicus	188-192
1901415-8	1991	IL-1 alpha reduced basal LHRH release and blocked LHRH release induced by norepinephrine.	Norepinephrine	74-88	gonadotropin releasing hormone 1	Rattus norvegicus	50-54
1801509-2	1991	The decreases found in hypothalamic norepinephrine and dopamine are particularly important since they lead to reduced gonadotropic hormone secretin and cessation of estrous cycles in female rats and a decrease in testosterone secretion in male rats, lower GH and somatomedin (IGF-I) secretion and reduced protein synthesis, diminished thyroid hormone secretion and lower body metabolism, higher PRL secretion and development of numerous mammary and pituitary tumours, and reduced immune competence.	Norepinephrine	36-50	insulin-like growth factor 1	Rattus norvegicus	263-274
1801509-2	1991	The decreases found in hypothalamic norepinephrine and dopamine are particularly important since they lead to reduced gonadotropic hormone secretin and cessation of estrous cycles in female rats and a decrease in testosterone secretion in male rats, lower GH and somatomedin (IGF-I) secretion and reduced protein synthesis, diminished thyroid hormone secretion and lower body metabolism, higher PRL secretion and development of numerous mammary and pituitary tumours, and reduced immune competence.	Norepinephrine	36-50	insulin-like growth factor 1	Rattus norvegicus	276-281
1840112-1	1991	The effects of Type 1 diabetes mellitus and of exposure to mainstream cigarette smoke on noradrenaline (NA) uptake and its subsequent metabolism by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO) in the perfused lungs of rats were examined.	Norepinephrine	89-102	catechol-O-methyltransferase	Rattus norvegicus	178-182
1721688-4	1991	This action of neuropeptide Y could contribute to analgesia, particularly if this neuropeptide is co-released with noradrenaline from axon terminals in the superficial dorsal horn.	Norepinephrine	115-128	neuropeptide Y	Homo sapiens	15-29
1861777-2	1991	Treatment with FLA63, an inhibitor of dopamine beta-hydroxylase (10 mg/kg, 2 h before killing), induced depletion of noradrenaline and adrenaline in the preoptic area and median eminence (sites, respectively, inside and outside the blood-brain barrier) but, paradoxically, resulted in a significant increase (+77%) in the pineal content of adrenaline without affecting that of noradrenaline.	Norepinephrine	117-130	dopamine beta-hydroxylase	Rattus norvegicus	38-63
2292030-2	1990	Neonatal depletion of noradrenaline by daily subcutaneous injections of clonidine results in supersensitivity to noradrenaline in adult hippocampal CA1 cells as shown in our previous microiontophoretic study.	Norepinephrine	22-35	carbonic anhydrase 1	Rattus norvegicus	148-151
2292030-2	1990	Neonatal depletion of noradrenaline by daily subcutaneous injections of clonidine results in supersensitivity to noradrenaline in adult hippocampal CA1 cells as shown in our previous microiontophoretic study.	Norepinephrine	113-126	carbonic anhydrase 1	Rattus norvegicus	148-151
2079356-1	1990	3,4-Dihydroxyphenyl ethylene glycol (DOPEG), a metabolite of noradrenaline (NA), was estimated in CSF of 30 patients of depression diagnosed by the criteria of American Psychiatric Association in DSM-III; and compared with levels in 10 non-depressed individuals who served as controls.	Norepinephrine	61-74	colony stimulating factor 2	Homo sapiens	98-101
1979873-4	1990	Although THC (10 nM) did not alter basal release of LH-releasing hormone (LHRH) from MEs in vitro, it completely blocked the stimulatory action of dopamine or norepinephrine on LHRH release.	Norepinephrine	159-173	gonadotropin releasing hormone 1	Rattus norvegicus	177-181
2173628-4	1990	Since DBH is coreleased with norepinephrine, these results indicate that a functional coupling of the putative beta-adrenergic receptor with DBH may exist in cardiac muscle.	Norepinephrine	29-43	dopamine beta-hydroxylase	Homo sapiens	141-144
2285243-5	1990	rIL-2, at concentrations of 0.1-1000 U/ml, did not induce any modification of perfusion pressure in isolated rat tail artery but produced a significant displacement to the left of the dose-response curves for norepinephrine compared to basal conditions.	Norepinephrine	209-223	interleukin 2	Rattus norvegicus	0-5
1980236-2	1990	The alpha receptor is divided into two types, alpha 1 and alpha 2, based on response to epinephrine and norepinephrine.	Norepinephrine	104-118	adrenoceptor alpha 1D	Homo sapiens	46-65
2129867-5	1990	We propose that the DBH/NPY/NGF-R-positive adrenal medullary ganglion cells are sympathetic postganglionic neurons producing noradrenaline.	Norepinephrine	125-138	dopamine beta-hydroxylase	Rattus norvegicus	20-23
2233767-5	1990	However in an adolescent boy with renal hypertension plasma concentration of noradrenaline and NPY fell following clonidine application (noradrenaline from 1.9 to 1.3 nmol/l, NPY from 3.6 to 2.4 pmol/l).	Norepinephrine	77-90	neuropeptide Y	Homo sapiens	175-178
2233767-5	1990	However in an adolescent boy with renal hypertension plasma concentration of noradrenaline and NPY fell following clonidine application (noradrenaline from 1.9 to 1.3 nmol/l, NPY from 3.6 to 2.4 pmol/l).	Norepinephrine	137-150	neuropeptide Y	Homo sapiens	95-98
1698642-1	1990	Galanin and neuropeptide Y are known to coexist with noradrenaline in neurones of the locus coeruleus.	Norepinephrine	53-66	neuropeptide Y	Homo sapiens	12-26
2364490-1	1990	Neuropeptide Y (NPY) is stored with norepinephrine in sympathetic nerves throughout the cardiovascular system and is released during activation of the sympathetic nervous system in humans and other animals.	Norepinephrine	36-50	neuropeptide Y	Homo sapiens	0-14
2364490-1	1990	Neuropeptide Y (NPY) is stored with norepinephrine in sympathetic nerves throughout the cardiovascular system and is released during activation of the sympathetic nervous system in humans and other animals.	Norepinephrine	36-50	neuropeptide Y	Homo sapiens	16-19
2384133-0	1990	The neuropeptides vasoactive intestinal polypeptide, peptide histidine isoleucine and neuropeptide Y modulate [3H]noradrenaline release from sympathetic nerves in the choroid plexus.	Norepinephrine	114-127	vasoactive intestinal peptide	Sus scrofa	18-51
2172554-3	1990	ODC activity peaked 4 h after the addition of serum and returned to initial levels at 8 h. In the absence of serum, non-cytotoxic concentrations of the adrenergic agonists epinephrine, norepinephrine or isoproterenol did not stimulate ODC activity.	Norepinephrine	185-199	ornithine decarboxylase 1	Rattus norvegicus	0-3
19210375-0	1990	A comparison of the effects of medial preoptic electrical versus electrochemical stimulation on luteinizing hormone-releasing hormone neuronal responsiveness to norepinephrine.	Norepinephrine	161-175	gonadotropin releasing hormone 1	Rattus norvegicus	96-133
19210375-1	1990	Abstract Recently, we reported that luteinizing hormone-releasing hormone (LHRH) neurons of estrogen-treated, ovariectomized rats have only limited responsiveness to norepinephrine (NE).	Norepinephrine	166-180	gonadotropin releasing hormone 1	Rattus norvegicus	36-73
1971714-3	1990	These measurements were repeated 2 weeks later, 2 h after the intravenous administration of 12.5 mg/kg of the dopamine-beta-hydroxylase inhibitor diethyldithiocarbamate (DDTC), which has been shown to be an effective norepinephrine synthesis inhibitor in the rat.	Norepinephrine	217-231	dopamine beta-hydroxylase	Rattus norvegicus	110-135
2164166-5	1990	These findings confirm the role of NPY as a co-transmitter at ocular sympathetic neuroeffector junctions, either mimicking or augmenting the actions of endogenously released norepinephrine.	Norepinephrine	174-188	neuropeptide Y	Oryctolagus cuniculus	35-38
2311663-6	1990	Contractile responses to exogenous noradrenaline (1 microM) and alpha,beta-methylene ATP (1 microM) were both significantly potentiated following incubation with neuropeptide Y (0.3 microM); the degree of potentiation being similar for both agonists.	Norepinephrine	35-48	neuropeptide Y	Oryctolagus cuniculus	162-176
2174218-1	1990	The coexistence of neuropeptide Y (NPY) with noradrenaline (NA) in perivascular nerves as well as in sympathetic nerves to muscle in the heart, spleen and vas deferens suggests a role for NPY in autonomic transmission.	Norepinephrine	45-58	neuropeptide Y	Homo sapiens	35-38
2174219-13	1990	In addition, some of the NPY-axons in the ventral portions of striatum and cerebral cortex may be catecholaminergic, and thus originate in brainstem areas recognized to contain NPY and epinephrine or norepinephrine.	Norepinephrine	200-214	neuropeptide Y	Homo sapiens	25-28
1970494-10	1990	The combination of the two antagonists at the above-mentioned concentrations caused a marked, parallel shift to the right of the noradrenaline concentration-response curve, the shift of the pD2 was 2.68.	Norepinephrine	129-142	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	190-193
33779845-11	2021	The present study provides evidence that GnRH from CG may trigger neuronal signals that promote the luteal regression in late pregnancy by affecting the release of NO and noradrenaline in the ovary.	Norepinephrine	171-184	gonadotropin releasing hormone 1	Rattus norvegicus	41-45
33801190-12	2021	Partial correlation (controlling for age, gender and Body Mass Index (BMI)) revealed a significant direct relation between MCP-1 and norepinephrine (r = 0.47, p = 0.03) and MCP-1 and epinephrine (r = 0.46, p = 0.04) in patients with -D+CAD at rest.	Norepinephrine	133-147	C-C motif chemokine ligand 2	Homo sapiens	123-128
34853408-6	2022	Norepinephrine further increased VEGF mRNA expression under hypoxia; this effect was abolished by doxazosin.	Norepinephrine	0-14	vascular endothelial growth factor A	Rattus norvegicus	33-37
34853408-11	2022	In conclusion, doxazosin abolished the beneficial effects of ADSC sheets on rat MI hearts as well as the enhancing effect of norepinephrine on VEGF expression in ADSCs, indicating that ADSC sheets promote angiogenesis and prevent cardiac dysfunction and remodeling after MI via their alpha1-ARs.	Norepinephrine	125-139	vascular endothelial growth factor A	Rattus norvegicus	143-147
34923109-2	2022	Among these, Monoamine oxidase A (MAOA) catalyzes the degradation of dopamine, norepinephrine, and serotonin into their inactive metabolites.	Norepinephrine	79-93	monoamine oxidase A	Homo sapiens	13-32
34923109-2	2022	Among these, Monoamine oxidase A (MAOA) catalyzes the degradation of dopamine, norepinephrine, and serotonin into their inactive metabolites.	Norepinephrine	79-93	monoamine oxidase A	Homo sapiens	34-38
34767786-8	2021	SIGNIFICANCE The beta2-adrenergic receptor (beta2 AR), which belongs to the vast family of Guanine nucleotide-binding protein coupled receptors (GPCRs), is a transmembrane protein that is activated by the catecholamines norepinephrine (noradrenaline) and epinephrine (adrenaline).	Norepinephrine	220-234	adenosine A2a receptor	Homo sapiens	44-52
34767786-8	2021	SIGNIFICANCE The beta2-adrenergic receptor (beta2 AR), which belongs to the vast family of Guanine nucleotide-binding protein coupled receptors (GPCRs), is a transmembrane protein that is activated by the catecholamines norepinephrine (noradrenaline) and epinephrine (adrenaline).	Norepinephrine	236-249	adenosine A2a receptor	Homo sapiens	44-52
34837110-7	2022	These results suggest that noradrenaline may act on the basement membrane of the proximal tubules through alpha2A- and alpha2B-adrenoceptors.	Norepinephrine	27-40	spectrin, alpha, non-erythrocytic 1	Rattus norvegicus	106-113
34772699-5	2021	We report that norepinephrine treatment dramatically altered moMF cytokine production, whereas DCs were unresponsive to norepinephrine and critically lack beta2-adrenergic receptor expression.	Norepinephrine	15-29	adrenergic receptor, beta 2	Mus musculus	155-180
34713714-8	2021	The effects of norepinephrine on the expression of GLP-1R and neprilysin in kidney epithelial LLC-PK1 cells were also examined.	Norepinephrine	15-29	glucagon like peptide 1 receptor	Sus scrofa	51-57
34870059-13	2021	Histological findings in our case give a possible hypothesis that the mechanism underlying a dopamine-secreting pheochromocytoma is associated with immature catecholamine vesicles in which dopamine beta-hydroxylase is localized, thus resulting in inhibited conversion from dopamine to norepinephrine.	Norepinephrine	285-299	dopamine beta-hydroxylase	Homo sapiens	189-214
34074423-6	2021	The linearity was 0.25-500 ng mL-1 for norepinephrine, epinephrine, dopamine, normetanephrine 3-methoxytyramine, serotonin, histamine, and 0.1-500 ng mL-1 for metanephrine.	Norepinephrine	39-53	L1 cell adhesion molecule	Mus musculus	30-34
34275002-9	2021	The expression of Bmal1, Per1 and Per3 in control subjects was also influenced by incubation with 1 microM norepinephrine.	Norepinephrine	107-121	period circadian regulator 3	Homo sapiens	34-38
34275002-12	2021	Per3 expression at ZT4 was significant higher in the group of control samples incubated with 1 microM norepinephrine, compared to the control group without norepinephrine.	Norepinephrine	102-116	period circadian regulator 3	Homo sapiens	0-4
34104996-8	2021	With the proposed method, the linearity range was from 0.500 to 500 ng mL-1 for norepinephrine and epinephrine and from 1.00 to 500 ng mL-1 for dopamine.	Norepinephrine	80-94	L1 cell adhesion molecule	Mus musculus	71-75
34104996-9	2021	The detection limits were 0.050, 0.11, and 0.20 ng mL-1 for norepinephrine, epinephrine, and dopamine, respectively.	Norepinephrine	60-74	L1 cell adhesion molecule	Mus musculus	51-55
35597124-6	2022	The effect of norepinephrine (NE), acetylcholine (ACh) and neuregulin-1 (NRG-1) on alpha7nAChR expression was detected by real-time PCR.	Norepinephrine	14-28	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	83-94
35498018-8	2022	Furthermore, in vitro experiments using cardiac myocytes demonstrated that miR-145-5p mimic transfection up-regulated the expression of brain and atrial natriuretic peptide genes, which are markers of cardiac hypertrophy, while anti-miR-145-5p transfection abrogated the expression of these genes in response to norepinephrine stimulus.	Norepinephrine	312-326	microRNA 145	Homo sapiens	75-82
35498018-8	2022	Furthermore, in vitro experiments using cardiac myocytes demonstrated that miR-145-5p mimic transfection up-regulated the expression of brain and atrial natriuretic peptide genes, which are markers of cardiac hypertrophy, while anti-miR-145-5p transfection abrogated the expression of these genes in response to norepinephrine stimulus.	Norepinephrine	312-326	microRNA 145	Homo sapiens	233-240
35045722-2	2022	We previously showed that DPP4 inhibition attenuates the hypotensive effect of acute ACE (angiotensin-converting enzyme) inhibition and increases norepinephrine.	Norepinephrine	146-160	dipeptidyl peptidase 4	Homo sapiens	26-30
35045722-6	2022	RESULTS: We found that DPP4 inhibition increased norepinephrine during ramipril but did not increase blood pressure.	Norepinephrine	49-63	dipeptidyl peptidase 4	Homo sapiens	23-27
35327387-6	2022	UCP1 expression correlated only with norepinephrine levels and its metabolite.	Norepinephrine	37-51	uncoupling protein 1	Homo sapiens	0-4
35327387-10	2022	CONCLUSION: We demonstrate signs of UCP1-dependent norepinephrine-induced thermogenesis connected with higher expression of DIO2, PPARGC1A, CEBPB and PRDM16 in retroperitoneal VAT of PPGL and its relations to circulating HDLc and triglycerides levels.	Norepinephrine	51-65	uncoupling protein 1	Homo sapiens	36-40
35327387-10	2022	CONCLUSION: We demonstrate signs of UCP1-dependent norepinephrine-induced thermogenesis connected with higher expression of DIO2, PPARGC1A, CEBPB and PRDM16 in retroperitoneal VAT of PPGL and its relations to circulating HDLc and triglycerides levels.	Norepinephrine	51-65	iodothyronine deiodinase 2	Homo sapiens	124-128
34854078-0	2022	Elevated norepinephrine may interact with alpha-synuclein to promote Parkinson"s disease and DLB.	Norepinephrine	9-23	synuclein alpha	Homo sapiens	42-57
2557415-10	1989	The reduction of [Ca++]i by nicorandil may result in a decrease in Ca++ in the norepinephrine-sensitive store; hence, the reduction of [Ca++]i elevation by norepinephrine.	Norepinephrine	79-93	carbonic anhydrase 1	Rattus norvegicus	18-24
2557415-10	1989	The reduction of [Ca++]i by nicorandil may result in a decrease in Ca++ in the norepinephrine-sensitive store; hence, the reduction of [Ca++]i elevation by norepinephrine.	Norepinephrine	79-93	carbonic anhydrase 1	Rattus norvegicus	136-142
2557415-10	1989	The reduction of [Ca++]i by nicorandil may result in a decrease in Ca++ in the norepinephrine-sensitive store; hence, the reduction of [Ca++]i elevation by norepinephrine.	Norepinephrine	156-170	carbonic anhydrase 1	Rattus norvegicus	18-24
2557415-10	1989	The reduction of [Ca++]i by nicorandil may result in a decrease in Ca++ in the norepinephrine-sensitive store; hence, the reduction of [Ca++]i elevation by norepinephrine.	Norepinephrine	156-170	carbonic anhydrase 1	Rattus norvegicus	136-142
2612490-2	1989	In this study, the immunocytochemical localization of dopamine beta-hydroxylase (DBH), the synthesizing enzyme for norepinephrine, was compared between GEPR-9s and SD rats.	Norepinephrine	115-129	dopamine beta-hydroxylase	Rattus norvegicus	54-79
2612490-2	1989	In this study, the immunocytochemical localization of dopamine beta-hydroxylase (DBH), the synthesizing enzyme for norepinephrine, was compared between GEPR-9s and SD rats.	Norepinephrine	115-129	dopamine beta-hydroxylase	Rattus norvegicus	81-84
2574070-4	1989	However, there was a significantly stronger depression of glutamate-evoked activity of CA1 pyramidal neurons by noradrenaline in the clonidine-treated rats.	Norepinephrine	112-125	carbonic anhydrase 1	Rattus norvegicus	87-90
2743742-1	1989	The purpose of the present study was to evaluate whether neuropeptide Y, which coexists with noradrenaline in sympathetic nerves, may be released upon cigarette smoking.	Norepinephrine	93-106	neuropeptide Y	Homo sapiens	57-71
2743742-4	1989	Systemic plasma levels of noradrenaline and neuropeptide Y were significantly elevated after 3 and 5 min of smoking, respectively, and reached maximal values (neuropeptide Y from 32 +/- 4 to 49 +/- 7 pmol l-1, and noradrenaline from 0.72 +/- 0.16 to 1.8 +/- 0.44 nmol l-1) 2-5 min after the smoking period.	Norepinephrine	26-39	neuropeptide Y	Homo sapiens	159-173
2743742-4	1989	Systemic plasma levels of noradrenaline and neuropeptide Y were significantly elevated after 3 and 5 min of smoking, respectively, and reached maximal values (neuropeptide Y from 32 +/- 4 to 49 +/- 7 pmol l-1, and noradrenaline from 0.72 +/- 0.16 to 1.8 +/- 0.44 nmol l-1) 2-5 min after the smoking period.	Norepinephrine	214-227	neuropeptide Y	Homo sapiens	44-58
2544045-7	1989	Hypothalamic norepinephrine and serum corticosterone levels increased in a dose-related manner after 2 weeks of T-2 exposure.	Norepinephrine	13-27	brachyury 2	Mus musculus	112-115
2707360-1	1989	Noradrenergic input to the rat substantia innominata (SI) was analyzed in this study by immunocytochemical localization of dopamine beta-hydroxylase (DBH), the synthetic enzyme for noradrenaline.	Norepinephrine	181-194	dopamine beta-hydroxylase	Rattus norvegicus	123-148
2707360-1	1989	Noradrenergic input to the rat substantia innominata (SI) was analyzed in this study by immunocytochemical localization of dopamine beta-hydroxylase (DBH), the synthetic enzyme for noradrenaline.	Norepinephrine	181-194	dopamine beta-hydroxylase	Rattus norvegicus	150-153
2709335-0	1989	Stimulation of histamine H2 receptor in rat hypothalamus releases endogenous norepinephrine.	Norepinephrine	77-91	histamine receptor H 2	Rattus norvegicus	15-36
2566254-4	1989	We also present data on the CSF metabolites dopamine, norepinephrine and serotonin of one patient.	Norepinephrine	54-68	colony stimulating factor 2	Homo sapiens	28-31
2765685-1	1989	Human anaphylatoxin C5a injected directly to the perifornical hypothalamus (PFH) of the rat elicits food intake in sated rats, an effect which mimics that of norepinephrine (NE) at the PFH.	Norepinephrine	158-172	complement C5	Rattus norvegicus	20-23
2708265-1	1989	It was the purpose of this investigation to examine any age-related changes in norepinephrine turnover (NEt) in four tissues at rest and during exercise.	Norepinephrine	79-93	solute carrier family 6 member 2	Rattus norvegicus	104-107
2706916-1	1989	Neuropeptide Y (NPY) has recently been shown be co-released with noradrenaline (NA) from sympathetic nerves and to cause arterial vasoconstriction in experimental animals and man.	Norepinephrine	65-78	neuropeptide Y	Homo sapiens	16-19
2924106-3	1989	By light microscopy, varicose processes showing intense PNMT-like immunoreactivity (LI) were seen throughout the neuropil surrounding neuronal perikarya which in adjacent sections were shown to contain immunoreactivity for the noradrenaline synthesizing enzyme, dopamine-beta-hydroxylase.	Norepinephrine	227-240	phenylethanolamine-N-methyltransferase	Rattus norvegicus	56-60
2743605-1	1989	Neuropeptide Y (NPY) coexists with noradrenaline in postganglionic sympathetic neurons and with noradrenaline and adrenaline in the central nervous system.	Norepinephrine	35-48	neuropeptide Y	Homo sapiens	0-14
2743605-1	1989	Neuropeptide Y (NPY) coexists with noradrenaline in postganglionic sympathetic neurons and with noradrenaline and adrenaline in the central nervous system.	Norepinephrine	35-48	neuropeptide Y	Homo sapiens	16-19
2743605-1	1989	Neuropeptide Y (NPY) coexists with noradrenaline in postganglionic sympathetic neurons and with noradrenaline and adrenaline in the central nervous system.	Norepinephrine	96-109	neuropeptide Y	Homo sapiens	0-14
2743605-1	1989	Neuropeptide Y (NPY) coexists with noradrenaline in postganglionic sympathetic neurons and with noradrenaline and adrenaline in the central nervous system.	Norepinephrine	96-109	neuropeptide Y	Homo sapiens	16-19
2468936-3	1989	After exposure of cerebral arteries to 1.5 nM NPY, the potencies of norepinephrine (NE) and histamine in causing contraction were increased by approximately twofold, with no change in maximal contraction.	Norepinephrine	68-82	neuropeptide Y	Oryctolagus cuniculus	46-49
3146034-9	1988	In 39 and 20% of the 119 neurons tested, the norepinephrine responses were potentiated and attenuated, respectively, by luteinizing hormone-releasing hormone.	Norepinephrine	45-59	gonadotropin releasing hormone 1	Rattus norvegicus	120-157
3066432-1	1988	Previously, we demonstrated immunocytochemically that certain phenylethanolamine N-methyltransferase neurons in the inner nuclear layer of rat retina contain other catecholamine synthesizing enzymes, including tyrosine hydroxylase and aromatic-L-amino acid decarboxylase but not dopamine beta-hydroxylase (DBH), the norepinephrine biosynthetic enzyme.	Norepinephrine	316-330	phenylethanolamine-N-methyltransferase	Rattus norvegicus	62-100
2899914-6	1988	Norepinephrine (mixed alpha 1- and alpha 2-agonist) significantly increased intestinal absorption and vascular resistance.	Norepinephrine	0-14	adrenoceptor alpha 1D	Homo sapiens	22-42
3262452-4	1988	Incubation of rat aortas with human monocyte-derived interleukin 1 or recombinant human tumor necrosis factor resulted in diminished aortic contraction and sensitivity to norepinephrine, and gel filtration of medium conditioned by endotoxin-stimulated macrophages yielded suppressive activity at a molecular weight equivalent to interleukin 1 and tumor necrosis factor.	Norepinephrine	171-185	interleukin 1 alpha	Homo sapiens	53-66
2899848-8	1988	Results of this study support the hypothesis that epinephrine and/or norepinephrine regulate the release of ACTH and vasopressin via alpha-1- and alpha-2-adrenergic receptors associated with CRF- and VP-containing somata within the PVN.	Norepinephrine	69-83	adrenoceptor alpha 1D	Homo sapiens	133-141
3271616-2	1988	In the isolated perfused and superfused rabbit ear artery, neuropeptide Y (NPY, 0.3-100 nmol/l) had no direct vasoconstrictor action, but produced a concentration-dependent and reversible enhancement of vasoconstrictor responses to both sympathetic nerve stimulation and exogenous noradrenaline.	Norepinephrine	281-294	neuropeptide Y	Oryctolagus cuniculus	59-73
3285962-1	1988	The effect of age on norepinephrine (NE) stimulation of luteinizing hormone-releasing hormone (LH-RH) secretion from preoptic area-mediobasal hypothalamic (POA-MBH) explants was examined in the present study.	Norepinephrine	21-35	gonadotropin releasing hormone 1	Rattus norvegicus	95-100
3358538-2	1988	It is postulated that since hypothalamic norepinephrine (NE) is known to inhibit corticotropin-releasing hormone (CRH), an increase in brain NE as measured by its metabolite 3-methoxy-4-hydroxy-phenylglycol (MHPG) could reflect the depression of the hypothalamic-pituitary-adrenal (HPA) axis as measured by urinary cortisol levels.	Norepinephrine	41-55	corticotropin releasing hormone	Homo sapiens	81-112
3358538-2	1988	It is postulated that since hypothalamic norepinephrine (NE) is known to inhibit corticotropin-releasing hormone (CRH), an increase in brain NE as measured by its metabolite 3-methoxy-4-hydroxy-phenylglycol (MHPG) could reflect the depression of the hypothalamic-pituitary-adrenal (HPA) axis as measured by urinary cortisol levels.	Norepinephrine	41-55	corticotropin releasing hormone	Homo sapiens	114-117
2843588-0	1988	Eicosapentaenoic acid inhibits vasoconstrictor- and noradrenaline-potentiating effects of neuropeptide Y in the isolated rabbit ear.	Norepinephrine	52-65	neuropeptide Y	Oryctolagus cuniculus	90-104
2834010-1	1988	The effects of norepinephrine (NE) on inhibitory synaptic potentials were studied on CA1 pyramidal neurons in the hippocampal slice in vitro.	Norepinephrine	15-29	carbonic anhydrase 1	Rattus norvegicus	85-88
2834010-2	1988	Norepinephrine caused the appearance of multiple population spikes in the CA1 region of the hippocampal slice, reminiscent of the actions of gamma-aminobutyric acid (GABA) antagonists.	Norepinephrine	0-14	carbonic anhydrase 1	Rattus norvegicus	74-77
2897878-4	1987	Norepinephrine (NE) released from superior cervical ganglion (SCG) neurons that provide sympathetic innervation to the pineal acts through alpha1- and beta 1- adrenoceptors to stimulate melatonin synthesis and release.	Norepinephrine	0-14	adrenoceptor alpha 1D	Homo sapiens	139-157
3431657-0	1987	Involvement of 5-lipoxygenase pathway in norepinephrine stimulation of rat pineal melatonin synthesis.	Norepinephrine	41-55	arachidonate 5-lipoxygenase	Rattus norvegicus	15-29
3497798-0	1987	Facilitation of immunoreactive corticotropin-releasing factor secretion into the hypophysial-portal circulation after activation of catecholaminergic pathways or central norepinephrine injection.	Norepinephrine	170-184	corticotropin releasing hormone	Homo sapiens	31-61
3683592-6	1987	The kCOMT values for all four catecholamines, (-)-noradrenaline, dopamine, (-)-adrenaline and (+/-)-isoprenaline exhibit a range from 0.24 to 0.78 min-1; the metabolism of the catecholamines by the COMT differs: (-)-noradrenaline = dopamine less than (-)-adrenaline less than (+/-)-isoprenaline.	Norepinephrine	46-63	catechol-O-methyltransferase	Rattus norvegicus	5-9
3623070-5	1987	Injection of norepinephrine into the dorsal lymph sac of Xenopus caused immediate secretion and depletion from skin of PAM activity but did not cause a comparable immediate decrease in skin levels of cerulein mRNA or total RNA.	Norepinephrine	13-27	peptidylglycine alpha-amidating monooxygenase L homeolog	Xenopus laevis	119-122
2884858-1	1987	Doxazosin is a competitive inhibitor of norepinephrine at alpha 1 adrenoceptors on vascular smooth muscle, where it blocks vasoconstriction.	Norepinephrine	40-54	adrenoceptor alpha 1D	Homo sapiens	58-65
2953624-2	1987	ANF caused a concentration-dependent relaxation in arterial strips submaximally precontracted with noradrenaline, 5-hydroxytryptamine, or high-potassium solution (10-30 mM).	Norepinephrine	99-112	natriuretic peptide A	Canis lupus familiaris	0-3
3100285-1	1987	Ca2+-dependent and TSH-, norepinephrine (NE)-, and A23187-induced iodide (I-) efflux from FRTL-5 rat thyroid cells is inhibited by quinacrine and trifluoroperazine, agents that inhibit phospholipase A2 activity.	Norepinephrine	25-39	phospholipase A2 group IB	Rattus norvegicus	185-201
3611599-1	1987	In agreement with the inhibition of dopamine-beta-hydroxylase by exposure to CS2, the extension of exposure time from 4 to 16 h increased dopamine concentrations in the hypothalmus and adrenals, and decreased noradrenaline concentration in the hypothalmus.	Norepinephrine	209-222	dopamine beta-hydroxylase	Rattus norvegicus	36-61
3304727-3	1987	An alternative approach to stimulating dopamine receptors, while at the same time blunting sympathetic nervous system activity, would be by inhibiting the enzyme dopamine beta-hydroxylase (D beta H), thus increasing the cardiovascular and renal ratio of dopamine to norepinephrine.	Norepinephrine	266-280	dopamine beta-hydroxylase	Rattus norvegicus	162-187
3099112-7	1986	It seems probable that ascorbate may enhance the activity of endogenous norepinephrine in the MBH and, thereby, lead to increased release of LHRH.	Norepinephrine	72-86	gonadotropin releasing hormone 1	Rattus norvegicus	141-145
3492236-1	1986	Corticotropin-releasing factor (CRF) has been microinjected into different brain areas in an effort to characterize specific sites of action of this peptide to influence the concentrations of norepinephrine in plasma.	Norepinephrine	192-206	corticotropin releasing hormone	Homo sapiens	0-30
2946569-2	1986	Since abnormalities in several of these functions are observed in diabetic subjects, we investigated the effects of streptozotocin-induced diabetes on the activity of the enzyme that converts norepinephrine to epinephrine [phenylethanolamine N-methyltransferase (PNMT)] in the brainstem and hypothalamus of the rat.	Norepinephrine	192-206	phenylethanolamine-N-methyltransferase	Rattus norvegicus	223-261
3022291-4	1986	The alpha-adrenergic agonist norepinephrine (0.002-20 microM) increased levels of c-myc-encoded mRNA to 10-fold over control levels.	Norepinephrine	29-43	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	82-87
3783085-2	1986	Various inhibitors of phenylethanolamine N-methyltransferase (PNMT), the enzyme which catalyses the conversion of noradrenaline to adrenaline, were administered to freely moving ovariectomized rats bearing an atrial cannula.	Norepinephrine	114-127	phenylethanolamine-N-methyltransferase	Rattus norvegicus	22-60
3783085-2	1986	Various inhibitors of phenylethanolamine N-methyltransferase (PNMT), the enzyme which catalyses the conversion of noradrenaline to adrenaline, were administered to freely moving ovariectomized rats bearing an atrial cannula.	Norepinephrine	114-127	phenylethanolamine-N-methyltransferase	Rattus norvegicus	62-66
3730591-4	1986	The difference was revealed between the influence of some drugs on deamination of two monoamine oxidase A substrates: norepinephrine and serotonin.	Norepinephrine	118-132	monoamine oxidase A	Bos taurus	86-105
3014521-1	1986	Evidence exists that a norepinephrine/prostaglandin E2 (PGE2)/cAMP pathway is involved in the regulation of luteinizing hormone-releasing hormone (LHRH) secretion.	Norepinephrine	23-37	gonadotropin releasing hormone 1	Rattus norvegicus	108-145
3014521-1	1986	Evidence exists that a norepinephrine/prostaglandin E2 (PGE2)/cAMP pathway is involved in the regulation of luteinizing hormone-releasing hormone (LHRH) secretion.	Norepinephrine	23-37	gonadotropin releasing hormone 1	Rattus norvegicus	147-151
3014521-5	1986	Activation of the PGE2/cAMP pathway by either norepinephrine, PGE2, or forskolin (a stimulator of adenylate cyclase) increased LHRH release.	Norepinephrine	46-60	gonadotropin releasing hormone 1	Rattus norvegicus	127-131
3014521-6	1986	Dioctanoylglycerol or phorbol ester in conjunction with either norepinephrine, PGE2 or forskolin resulted in an additive effect on LHRH release suggesting coexistence of both pathways.	Norepinephrine	63-77	gonadotropin releasing hormone 1	Rattus norvegicus	131-135
3717353-7	1986	Both norepinephrine and dopamine were rapidly metabolized by catechol-O-methyltransferase and monoamine oxidase, but renal phenolsulfotransferase appeared to have no action on the catecholamines.	Norepinephrine	5-19	catechol-O-methyltransferase	Rattus norvegicus	61-89
2426539-5	1986	Hypothalamic levels of norepinephrine were decreased during hypoxia [(inhibition of TH, MAO, and dopamine beta-hydroxylase (DBH)].	Norepinephrine	23-37	dopamine beta-hydroxylase	Rattus norvegicus	97-122
2426539-5	1986	Hypothalamic levels of norepinephrine were decreased during hypoxia [(inhibition of TH, MAO, and dopamine beta-hydroxylase (DBH)].	Norepinephrine	23-37	dopamine beta-hydroxylase	Rattus norvegicus	124-127
3714115-0	1986	Dissociated cells of foetal rat pallium grown in culture medium supplemented with noradrenaline: effects on the expression of neuron-specific enolase and cell adhesion molecule L1.	Norepinephrine	82-95	enolase 2	Rattus norvegicus	126-149
2943770-4	1986	Moreover, a significantly negative correlation was found between the CSF norepinephrine level and the pre-dexamethasone 4 p.m. plasma cortisol level in those endogenous depressed patients who had a positive DST response.	Norepinephrine	73-87	colony stimulating factor 2	Homo sapiens	69-72
3007540-0	1986	Norepinephrine decreases EGF binding in primary rat hepatocyte cultures.	Norepinephrine	0-14	epidermal growth factor	Rattus norvegicus	25-28
3007540-1	1986	Norepinephrine (NE) produced a dose-dependent inhibition of 125I-epidermal growth factor (EGF) binding to adult rat hepatocytes in primary culture.	Norepinephrine	0-14	epidermal growth factor	Rattus norvegicus	60-88
3007540-1	1986	Norepinephrine (NE) produced a dose-dependent inhibition of 125I-epidermal growth factor (EGF) binding to adult rat hepatocytes in primary culture.	Norepinephrine	0-14	epidermal growth factor	Rattus norvegicus	90-93
3005555-4	1986	Responses to norepinephrine in the presence of rauwolscine were antagonized by prazosin and are therefore mediated predominantly by alpha-1 adrenoceptors.	Norepinephrine	13-27	adrenoceptor alpha 1D	Homo sapiens	132-139
3517691-3	1986	The sensitivities of these responses to depression by phencyclidine was N-methyl-D-aspartic acid (IC50 0.4 microM) greater than noradrenaline (IC50 3.9 microM) greater than [D-Ala2,MePhe4,Gly-ol5]enkephalin (IC50 8.5 microM) greater than prolongation of the action potential (41% increase by 30 microM).	Norepinephrine	128-141	proenkephalin	Rattus norvegicus	196-206
3941078-1	1986	Presumptive evidence suggests that the brown fat mitochondrial uncoupling protein, thermogenin, is involved in the mechanism of stimulation of respiration by norepinephrine in the intact tissue.	Norepinephrine	158-172	uncoupling protein 1	Homo sapiens	83-94
3550891-0	1986	Neuropeptide Y: coexistence with noradrenaline.	Norepinephrine	33-46	neuropeptide Y	Homo sapiens	0-14
4079740-1	1985	Many experimental studies have utilized the activity of dopamine-beta-hydroxylase (DBH) as an index of sympathetic activity, since this enzyme is not submitted to uptake mechanisms or to enzymatic metabolism as are the circulating catecholamines norepinephrine (NE) and epinephrine (E).	Norepinephrine	246-260	dopamine beta-hydroxylase	Homo sapiens	56-81
4079740-1	1985	Many experimental studies have utilized the activity of dopamine-beta-hydroxylase (DBH) as an index of sympathetic activity, since this enzyme is not submitted to uptake mechanisms or to enzymatic metabolism as are the circulating catecholamines norepinephrine (NE) and epinephrine (E).	Norepinephrine	246-260	dopamine beta-hydroxylase	Homo sapiens	83-86
3840999-2	1985	The plasma levels of neuropeptide Y correlated better with the levels of noradrenaline than adrenaline, suggesting release of a neural origin.	Norepinephrine	73-86	neuropeptide Y	Homo sapiens	21-35
2999648-0	1985	Effects of noradrenaline on some potassium currents in CA1 neurones in rat hippocampal slices.	Norepinephrine	11-24	carbonic anhydrase 1	Rattus norvegicus	55-58
2864433-2	1985	Spontaneous and evoked release of epinephrine was markedly reduced, when rats were pretreated with 2,3-dichloro-alpha-methylbenzylamine, an inhibitor of phenylethanolamine N-methyltransferase, the enzyme catalyzing the formation of epinephrine from norepinephrine, 80 mg/kg i.p., before decapitation.	Norepinephrine	249-263	phenylethanolamine-N-methyltransferase	Rattus norvegicus	153-191
2864784-1	1985	The action of neuropeptide Y (NPY), which coexists with noradrenaline (NA) in perivascular sympathetic nerves, has been examined on feline cerebrovascular smooth muscle using a sensitive in vitro system.	Norepinephrine	56-69	neuropeptide Y	Homo sapiens	14-28
2864784-1	1985	The action of neuropeptide Y (NPY), which coexists with noradrenaline (NA) in perivascular sympathetic nerves, has been examined on feline cerebrovascular smooth muscle using a sensitive in vitro system.	Norepinephrine	56-69	neuropeptide Y	Homo sapiens	30-33
2993777-0	1985	Dopamine-beta-hydroxylase inhibition acutely stimulates rats hypothalamic noradrenaline and dopamine neuronal activity as assessed from metabolic ratios and circulating glucose and ACTH responses.	Norepinephrine	74-87	dopamine beta-hydroxylase	Rattus norvegicus	0-25
2993777-1	1985	Because central noradrenaline neuronal activity is tonically inhibited by noradrenaline (NA) itself via an action at prejunctional alpha 2-adrenoceptors, it was hypothesised that the blockade of central NA synthesis following acute dopamine-beta -hydroxylase (DBH) inhibition might primarily deplete prejunctional NA levels and result in an increase in central NA neuronal activity through reduced NA autoinhibition.	Norepinephrine	74-87	dopamine beta-hydroxylase	Rattus norvegicus	232-258
3896847-0	1985	The effect of insulin and noradrenaline on the uptake of 2-[1-14C]deoxyglucose in vivo by brown adipose tissue and other glucose-utilising tissues of the mouse.	Norepinephrine	26-39	WD and tetratricopeptide repeats 1	Mus musculus	96-103
3896847-2	1985	When mice were treated with noradrenaline the rate of uptake of 2-[1-14C]deoxyglucose by brown adipose tissue was increased 6-fold with the only other change occurring in heart where a 5-fold increase was observed.	Norepinephrine	28-41	WD and tetratricopeptide repeats 1	Mus musculus	95-102
3896847-4	1985	The amount of 2-[1-14C]deoxyglucose taken up by brown adipose tissue compared to other tissues and the changes in this uptake after administration of noradrenaline or insulin suggest that brown adipose tissue is capable of playing a quantitatively important role in glucose removal from the blood.	Norepinephrine	150-163	WD and tetratricopeptide repeats 1	Mus musculus	54-61
3896847-4	1985	The amount of 2-[1-14C]deoxyglucose taken up by brown adipose tissue compared to other tissues and the changes in this uptake after administration of noradrenaline or insulin suggest that brown adipose tissue is capable of playing a quantitatively important role in glucose removal from the blood.	Norepinephrine	150-163	WD and tetratricopeptide repeats 1	Mus musculus	194-201
3928874-0	1985	Neuropeptide Y potentiates noradrenaline-evoked vasoconstriction: mode of action.	Norepinephrine	27-40	neuropeptide Y	Oryctolagus cuniculus	0-14
3928874-1	1985	Neuropeptide Y (NPY), which co-exists with noradrenaline (NA) in postganglionic sympathetic nerves, was able to potentiate NA-evoked constriction in certain isolated rabbit blood vessels.	Norepinephrine	43-56	neuropeptide Y	Oryctolagus cuniculus	0-14
3928874-1	1985	Neuropeptide Y (NPY), which co-exists with noradrenaline (NA) in postganglionic sympathetic nerves, was able to potentiate NA-evoked constriction in certain isolated rabbit blood vessels.	Norepinephrine	43-56	neuropeptide Y	Oryctolagus cuniculus	16-19
2863829-5	1985	Inasmuch as mepacrine and corticosterone antagonized the response to norepinephrine on PG release the possible involvement of the adrenergic agonist on the activity of phospholipase A2 is suggested.	Norepinephrine	69-83	phospholipase A2 group IB	Rattus norvegicus	168-184
2862967-6	1985	The putative role of corticotropin releasing factor as the mediator of norepinephrine and serotonin effects on feeding is discussed.	Norepinephrine	71-85	corticotropin releasing hormone	Homo sapiens	21-51
3991764-0	1985	Dopamine-beta-hydroxylase inhibitors, feeding and locomotor activity: reinstatement of feeding following central norepinephrine.	Norepinephrine	113-127	dopamine beta-hydroxylase	Rattus norvegicus	0-25
3925090-1	1985	Immunocytochemical localization of dopamine beta-hydroxylase (DBH) was used to study the synthesis and storage sites of norepinephrine (noradrenaline) in the rat and cat carotid bodies.	Norepinephrine	120-134	dopamine beta-hydroxylase	Rattus norvegicus	35-60
3925090-1	1985	Immunocytochemical localization of dopamine beta-hydroxylase (DBH) was used to study the synthesis and storage sites of norepinephrine (noradrenaline) in the rat and cat carotid bodies.	Norepinephrine	120-134	dopamine beta-hydroxylase	Rattus norvegicus	62-65
3925090-1	1985	Immunocytochemical localization of dopamine beta-hydroxylase (DBH) was used to study the synthesis and storage sites of norepinephrine (noradrenaline) in the rat and cat carotid bodies.	Norepinephrine	136-149	dopamine beta-hydroxylase	Rattus norvegicus	35-60
3925090-1	1985	Immunocytochemical localization of dopamine beta-hydroxylase (DBH) was used to study the synthesis and storage sites of norepinephrine (noradrenaline) in the rat and cat carotid bodies.	Norepinephrine	136-149	dopamine beta-hydroxylase	Rattus norvegicus	62-65
3925090-11	1985	Our results indicate that some of glomus cells in the rat and most of the glomus cells in the cat contain DBH and therefore may be sites of norepinephrine synthesis.	Norepinephrine	140-154	dopamine beta-hydroxylase	Rattus norvegicus	106-109
2982014-10	1985	When rats were pretreated with 2,3-dichloro-alpha-methylbenzylamine, an inhibitor of phenylethanolamine N-methyltransferase, the enzyme catalyzing the formation of epinephrine from norepinephrine, 80 mg/kg i.p.	Norepinephrine	181-195	phenylethanolamine-N-methyltransferase	Rattus norvegicus	85-123
3921855-6	1985	It is concluded that both MAO A and B are able to deaminate noradrenaline and NMN, but that in the intact tissue the former has no access to MAO B.	Norepinephrine	60-73	monoamine oxidase A	Canis lupus familiaris	26-31
3921856-0	1985	Influence of MAO A and MAO B on the inactivation of noradrenaline in the saphenous vein of the dog.	Norepinephrine	52-65	monoamine oxidase A	Canis lupus familiaris	13-18
3967057-3	1985	Lipase activity at pH 5.0 is completely inhibited by 0.2 M sodium fluoride and can be stimulated by norepinephrine (10 micrograms/ml).	Norepinephrine	100-114	lipase G, endothelial type	Rattus norvegicus	0-6
2408793-3	1985	Transplantable norepinephrine-rich tumors, which gave rise to significant blood pressure elevations, contained measurable immunoreactive enkephalins as determined by specific radioimmunoassays for leucine-enkephalin and methionine-enkephalin.	Norepinephrine	15-29	proenkephalin	Rattus norvegicus	137-147
6149973-1	1984	Phenylethanolamine N-methyltransferase (PNMT) is the enzyme that catalyzes the S-adenosyl-L-methionine-dependent methylation of (-)norepinephrine to (-)epinephrine in the adrenal medulla.	Norepinephrine	128-145	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-38
6149973-1	1984	Phenylethanolamine N-methyltransferase (PNMT) is the enzyme that catalyzes the S-adenosyl-L-methionine-dependent methylation of (-)norepinephrine to (-)epinephrine in the adrenal medulla.	Norepinephrine	128-145	phenylethanolamine-N-methyltransferase	Rattus norvegicus	40-44
6593107-3	1984	NPY greatly potentiated the response of the gastro-epiploic and femoral arteries to noradrenaline without affecting the maximum response.	Norepinephrine	84-97	neuropeptide Y	Oryctolagus cuniculus	0-3
6593107-5	1984	As tested on the femoral artery the potentiating effect of 30 nM NPY on noradrenaline-evoked contractions was apparent immediately and 30 min after the application of NPY, but not after one hour.	Norepinephrine	72-85	neuropeptide Y	Oryctolagus cuniculus	65-68
6593107-5	1984	As tested on the femoral artery the potentiating effect of 30 nM NPY on noradrenaline-evoked contractions was apparent immediately and 30 min after the application of NPY, but not after one hour.	Norepinephrine	72-85	neuropeptide Y	Oryctolagus cuniculus	167-170
6593107-6	1984	NPY (30 nM) potentiated the contractile response to noradrenaline and histamine but not to 5-hydroxytryptamine or high K+.	Norepinephrine	52-65	neuropeptide Y	Oryctolagus cuniculus	0-3
6489447-0	1984	[Leu5]enkephalin inhibits norepinephrine-induced contraction of rat aorta.	Norepinephrine	26-40	proenkephalin	Rattus norvegicus	6-16
6489447-1	1984	Leucine-enkephalin produces a dose related decrease in the contractile response of spirally cut strips of rat aorta to norepinephrine (NE).	Norepinephrine	119-133	proenkephalin	Rattus norvegicus	8-18
6476551-7	1984	Norepinephrine and epinephrine demonstrate activity at alpha 1, alpha 2, beta 1, and beta 2 receptor sites.	Norepinephrine	0-14	adrenoceptor alpha 1D	Homo sapiens	55-91
6473080-6	1984	The relative effect of catecholamines on steady-state pHi was: adrenaline = isoproterenol greater than noradrenaline.	Norepinephrine	103-116	glucose-6-phosphate isomerase	Rattus norvegicus	54-57
6733355-8	1984	produced profound decreases in dopamine-beta-hydroxylase activity in the frontal cortex and in the concentrations of noradrenaline in various brain regions indicating degeneration of the locus coeruleus noradrenaline system.	Norepinephrine	203-216	dopamine beta-hydroxylase	Rattus norvegicus	31-56
6709427-4	1984	Furthermore, the concentration of dopamine, norepinephrine, and epinephrine in the CSF increased significantly during the development of cerebral edema in all patients with Reye"s syndrome as compared with concentrations in a control population.	Norepinephrine	44-58	colony stimulating factor 2	Homo sapiens	83-86
6321867-0	1984	Desensitization of ornithine decarboxylase activity to norepinephrine in the testis of rat.	Norepinephrine	55-69	ornithine decarboxylase 1	Rattus norvegicus	19-42
6321867-1	1984	Injection of norepinephrine (NE) at a dose of 10 micrograms per testis caused the testis refractory in terms of ornithine decarboxylase (ODC) activity at 24 h. This desensitization was found to be both time and dose dependent.	Norepinephrine	13-27	ornithine decarboxylase 1	Rattus norvegicus	112-135
6321867-1	1984	Injection of norepinephrine (NE) at a dose of 10 micrograms per testis caused the testis refractory in terms of ornithine decarboxylase (ODC) activity at 24 h. This desensitization was found to be both time and dose dependent.	Norepinephrine	13-27	ornithine decarboxylase 1	Rattus norvegicus	137-140
6321867-2	1984	Injection with follicle stimulating hormone, luteinizing hormone, prostaglandin F2 alpha, cyclic AMP or epinephrine to norepinephrine desensitized testis caused stimulation of ODC activity.	Norepinephrine	119-133	ornithine decarboxylase 1	Rattus norvegicus	176-179
6693902-8	1984	Thus, if catechol-O-methyltransferase was inhibited during the injection of [3H]noradrenaline, a higher percentage of the amine had been taken up into spaces with a slow noradrenaline turnover.	Norepinephrine	80-93	catechol-O-methyltransferase	Rattus norvegicus	9-37
6693902-11	1984	The tropolone effect on the noradrenaline recovery possibly shows that there might be a saturable "methylating system," similar to that described for the periphery, in which catechol-O-methyltransferase is linked to the extraneuronal uptake2.	Norepinephrine	28-41	catechol-O-methyltransferase	Rattus norvegicus	174-202
6143680-2	1984	retarded the disappearance of noradrenaline induced by the dopamine-beta-hydroxylase (DBH) inhibitor FLA 63, in the hypothalamus, nucleus of the solitary tract (A-2/C-2 area), and lateral reticular nucleus (A-1/C-1 area) regions, while propranolol (20 mg/kg i.p.)	Norepinephrine	30-43	dopamine beta-hydroxylase	Rattus norvegicus	59-84
6143680-2	1984	retarded the disappearance of noradrenaline induced by the dopamine-beta-hydroxylase (DBH) inhibitor FLA 63, in the hypothalamus, nucleus of the solitary tract (A-2/C-2 area), and lateral reticular nucleus (A-1/C-1 area) regions, while propranolol (20 mg/kg i.p.)	Norepinephrine	30-43	dopamine beta-hydroxylase	Rattus norvegicus	86-89
6466878-4	1984	At a norepinephrine concentration of 0.5 microM, the frequency (f) of rhythmic contractions increases from 0.2 to 0.65 [sec-1], when the mean circumferential wall stress (sigma) is increased from 1 .	Norepinephrine	5-19	secretory blood group 1	Rattus norvegicus	120-125
6150762-4	1984	Dopamine beta-hydroxylase was identified in most paraganglionic cells, indicating that they synthesized norepinephrine.	Norepinephrine	104-118	dopamine beta-hydroxylase	Rattus norvegicus	0-25
6358412-4	1984	On the other hand, levels of NSE subunit (gamma subunit or 14-3-2 protein) in adipose tissue (0.51 +/- 0.03 gamma gamma-equivalent pmol/mg protein) were increased to 170% of control by serial injection (for 7 days) of epinephrine or norepinephrine with little change of the level of enolase alpha subunit on a mg protein basis.	Norepinephrine	233-247	enolase 2	Rattus norvegicus	29-32
6089242-1	1984	Stimulation of GABA receptors (e.g. by progabide, a new GABA receptor antagonist, or by muscimol) enhances the liberation of norepinephrine in limbic forebrain areas of the rat and reduces 5-hydroxytryptamine turnover.	Norepinephrine	125-139	GABA type A receptor-associated protein	Homo sapiens	15-28
6356136-3	1983	Inhibition of dopamine and norepinephrine synthesis with alpha-methyl-p-tyrosine (alpha-MT) reduced the LHRH content in the MBH in both oil- and EB-treated animals and partially reversed the decrease in plasma LH levels.	Norepinephrine	27-41	gonadotropin releasing hormone 1	Rattus norvegicus	104-108
6356136-4	1983	Inhibition of norepinephrine synthesis with fusaric acid decreased LHRH content in both oil- and EB-treated rats but had no effect on plasma LH levels.	Norepinephrine	14-28	gonadotropin releasing hormone 1	Rattus norvegicus	67-71
6352246-0	1983	Evidence that norepinephrine and epinephrine systems mediate the stimulatory effects of ovarian hormones on luteinizing hormone and luteinizing hormone-releasing hormone.	Norepinephrine	14-28	gonadotropin releasing hormone 1	Rattus norvegicus	132-169
6195471-8	1983	Neuronally released (--)-norepinephrine activated alpha 2-adrenoceptors, and its effect was attenuated by beta 2-adrenoceptor-mediated vasodilation in contrast to that of intravenously administered (--)-norepinephrine.	Norepinephrine	20-39	adrenoceptor beta 2	Rattus norvegicus	106-125
6414679-1	1983	Perfusion of 50 microM norepinephrine (NE) produced a marked, reversible decrease (range 20-28%) of the extracellular population spike and excitatory postsynaptic potential (EPSP) responses of the CA1 region evoked by stratum radiatum stimulation in the rat hippocampal slice preparation.	Norepinephrine	23-37	carbonic anhydrase 1	Rattus norvegicus	197-200
6368207-0	1983	Norepinephrine induces releases of both LH-RH from the hypothalamus and LH from the rat pituitary in vitro.	Norepinephrine	0-14	gonadotropin releasing hormone 1	Rattus norvegicus	40-45
6192235-5	1983	Subanalgesic doses of Leu-enkephalin or norepinephrine potentiated the antinociceptive activity of morphine in the substance P assay.	Norepinephrine	40-54	tachykinin 1	Mus musculus	115-126
6134515-1	1983	Dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine to norepinephrine, was measured in the CSF of 30 schizophrenic patients and 27 normal controls.	Norepinephrine	70-84	dopamine beta-hydroxylase	Homo sapiens	0-25
6134515-1	1983	Dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine to norepinephrine, was measured in the CSF of 30 schizophrenic patients and 27 normal controls.	Norepinephrine	70-84	dopamine beta-hydroxylase	Homo sapiens	27-30
6136632-2	1983	The catecholestrogen may act by its catechol A ring on the nucleus arcuatus COMT, consequently leaving the noradrenaline free.	Norepinephrine	107-120	catechol-O-methyltransferase	Rattus norvegicus	76-80
6835005-2	1983	Intracisternal administration of histamine or norepinephrine to developing rats produced age-dependent stimulation of ODC in brain.	Norepinephrine	46-60	ornithine decarboxylase 1	Rattus norvegicus	118-121
6835005-7	1983	Thus, the trophic effect of histamine or norepinephrine toward ODC activity is present or develops postnatally and appears to terminate with synaptogenesis and onset of neurotransmitter properties of the amines.	Norepinephrine	41-55	ornithine decarboxylase 1	Rattus norvegicus	63-66
6132592-5	1983	We also observed significant correlations between somatostatin and 5-hydroxyindoleacetic acid and norepinephrine in the CSF.	Norepinephrine	98-112	colony stimulating factor 2	Homo sapiens	120-123
6222267-7	1983	Phenylethanolamine N-methyltransferase, the enzyme responsible for converting noradrenaline to adrenaline, is shown to be inhibited in vivo by p-chlorophenylalanine and in vitro by its metabolite, p-chlorophenylethylamine.	Norepinephrine	78-91	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-38
6317336-9	1983	Moreover, modifications of dopamine-beta-hydroxylase, an enzyme that changes dopamine into noradrenaline, have been mentioned in some cases of autism.	Norepinephrine	91-104	dopamine beta-hydroxylase	Homo sapiens	27-52
6295557-3	1982	This report describes the effects of lithium on the central and peripheral levels of activity of dopamine-beta-hydroxylase (DBH), the enzyme that catalyzes the final step in the biosynthetic pathway to the formation of norepinephrine (NE) from dopamine.	Norepinephrine	219-233	dopamine beta-hydroxylase	Rattus norvegicus	97-122
6295557-3	1982	This report describes the effects of lithium on the central and peripheral levels of activity of dopamine-beta-hydroxylase (DBH), the enzyme that catalyzes the final step in the biosynthetic pathway to the formation of norepinephrine (NE) from dopamine.	Norepinephrine	219-233	dopamine beta-hydroxylase	Rattus norvegicus	124-127
7159481-0	1982	Monoamine oxidase type A: differences in selectivity towards l-norepinephrine compared to serotonin.	Norepinephrine	61-77	monoamine oxidase A	Homo sapiens	0-24
7159481-3	1982	Serotonin was a more selective substrate for MAO-A, being inhibited by low concentrations (less than 10(-7) M) of the irreversible MAO-A inhibitor, clorgyline, more consistently and to a greater extent (80-100%) than was l-norepinephrine (30-85%).	Norepinephrine	221-237	monoamine oxidase A	Homo sapiens	45-50
7159481-7	1982	Thus, l-norepinephrine, like dopamine, should be regarded as a substrate for both MAO-A and MAO-B in vitro.	Norepinephrine	6-22	monoamine oxidase A	Homo sapiens	82-87
7128025-2	1982	Phenylethanolamine N-methyltransferase (PNMT) converts noradrenaline into adrenaline and brain PNMT is elevated in spontaneously hypertensive and deoxycorticosterone acetate (DOCA)-salt hypertensive rats.	Norepinephrine	55-68	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-38
7128025-2	1982	Phenylethanolamine N-methyltransferase (PNMT) converts noradrenaline into adrenaline and brain PNMT is elevated in spontaneously hypertensive and deoxycorticosterone acetate (DOCA)-salt hypertensive rats.	Norepinephrine	55-68	phenylethanolamine-N-methyltransferase	Rattus norvegicus	40-44
7128025-2	1982	Phenylethanolamine N-methyltransferase (PNMT) converts noradrenaline into adrenaline and brain PNMT is elevated in spontaneously hypertensive and deoxycorticosterone acetate (DOCA)-salt hypertensive rats.	Norepinephrine	55-68	phenylethanolamine-N-methyltransferase	Rattus norvegicus	95-99
6290819-2	1982	After treatment of rats with a dopamine beta-hydroxylase inhibitor, 1-cyclohexyl-2-mercapto-imidazole (CHMI), there was a rapid increase in dopamine concentration even before norepinephrine concentration had decreased perceptibility.	Norepinephrine	175-189	dopamine beta-hydroxylase	Rattus norvegicus	31-56
6806317-2	1982	When CNS stores of norepinephrine (NE) were selectively reduced by the subcutaneous administration of the dopamine-beta-hydroxylase inhibitor FLA-63, TRH concentrations were significantly reduced throughout the brain.	Norepinephrine	19-33	dopamine beta-hydroxylase	Rattus norvegicus	106-131
7046838-3	1982	Intraventricular noradrenaline had a stimulating effect on the synthesis and secretion of LH-RH in both intact and castrated animals.	Norepinephrine	17-30	gonadotropin releasing hormone 1	Rattus norvegicus	90-95
7101471-2	1982	Dopamine-beta hydroxylase is stated to participate in manifestation of dopamine effect on the heart AMP-aminohydrolase, the same may be said with respect to monoaminooxidase in realization of the norepinephrine action on the brain AMP-aminohydrolase.	Norepinephrine	196-210	dopamine beta-hydroxylase	Homo sapiens	0-25
7098494-6	1982	After treating cultured rat pineal glands with l-norepinephrine (10 microM) for 6 hr, the concentration of acetyl coenzyme A was increased significantly from 3.26 +/- 0.37 to 10.24 +/- 0.93 pmol/gland, while the activity of serotonin N-acetyltransferase increased 68-fold.	Norepinephrine	47-63	aralkylamine N-acetyltransferase	Rattus norvegicus	224-253
6803810-6	1982	Alpha-substitution of DOPA, noradrenaline and isoprenaline causes a decrease in the affinity of catechol-O-methyltransferase for these compounds.	Norepinephrine	28-41	catechol-O-methyltransferase	Sus scrofa	96-124
6276133-1	1982	Studies were conducted to determine if the stimulatory effect that norepinephrine (NE) exerts on the release of prostaglandin E2 (PGE2) and LHRH from the median eminence is mediated by alpha- or beta-adrenergic receptors.	Norepinephrine	67-81	gonadotropin releasing hormone 1	Rattus norvegicus	140-144
7087247-0	1982	[An epidemiological study of the relationship between serum dopamine-beta-hydroxylase activity and urinary noradrenaline, and their relationship to blood pressure in women living in a rural area (author"s transl)].	Norepinephrine	107-120	dopamine beta-hydroxylase	Homo sapiens	60-85
7074998-10	1982	The altered relationship between noradrenaline content and DBH activity observed in young SHR when compared to WKY suggests a change in noradrenergic neurones activity and/or structure which could correspond to a genetically transmitted neurochemical abnormality associated with the initiation of hypertension in the SHR.	Norepinephrine	33-46	dopamine beta-hydroxylase	Rattus norvegicus	59-62
7105433-1	1982	Several medullary cardiovascular relay nuclei contain high concentrations of epinephrine and phenylethanolamine-N-methyl transferase (PNMT), the enzyme which catalyzes the conversion of norepinephrine to epinephrine.	Norepinephrine	186-200	phenylethanolamine-N-methyltransferase	Rattus norvegicus	93-132
7105433-1	1982	Several medullary cardiovascular relay nuclei contain high concentrations of epinephrine and phenylethanolamine-N-methyl transferase (PNMT), the enzyme which catalyzes the conversion of norepinephrine to epinephrine.	Norepinephrine	186-200	phenylethanolamine-N-methyltransferase	Rattus norvegicus	134-138
7183588-6	1982	In man, repetitive electrical stimulation via epidural electrodes increases plasma levels of norepinephrine, epinephrine, and dopamine, and CSF levels of norepinephrine.	Norepinephrine	154-168	colony stimulating factor 2	Homo sapiens	140-143
6127640-3	1982	Blockade of dopamine beta-hydroxylase activity by disulfiram depleted brain noradrenaline (NA) and decreased HPT-SRIF.	Norepinephrine	76-89	dopamine beta-hydroxylase	Rattus norvegicus	12-37
7327272-1	1981	One--day cold exposure decreases the monoamine oxidase type A activity by 52--54% (serotonin and noradrenaline substrates); the monoamine oxidase type B activity by 14%.	Norepinephrine	97-110	monoamine oxidase A	Homo sapiens	37-61
6798947-6	1981	Inhibitors of phospholipase A2 (mepacrine, p-bromophenacyl bromide) abolished the noradrenaline-induced PGE2-release and reduced the effect of A 23187; the stimulation of PGE2-release by arachidonic acid was not affected.	Norepinephrine	82-95	phospholipase A2	Oryctolagus cuniculus	14-30
6263414-1	1981	The effect of perfused norepinephrine (NE) on evoked potentials in CA1 of the in vitro rat hippocampus was examined.	Norepinephrine	23-37	carbonic anhydrase 1	Rattus norvegicus	67-70
7259893-0	1981	[Norepinephrine (NE) in cerebral vasospasm: assay of NE in CSF from patients with a ruptured intracranial aneurysm and its role in experimental vasospasm (author"s transl)].	Norepinephrine	1-15	colony stimulating factor 2	Homo sapiens	59-62
7224914-0	1981	CSF levels of norepinephrine during alcohol withdrawal.	Norepinephrine	14-28	colony stimulating factor 2	Homo sapiens	0-3
7242852-1	1981	The enzyme which converts to norepinephrine to epinephrine, phenylethanolamine N-methyltransferase (PNMT), is found in brain as well as in the adrenal medulla.	Norepinephrine	29-43	phenylethanolamine-N-methyltransferase	Rattus norvegicus	60-98
7242852-1	1981	The enzyme which converts to norepinephrine to epinephrine, phenylethanolamine N-methyltransferase (PNMT), is found in brain as well as in the adrenal medulla.	Norepinephrine	29-43	phenylethanolamine-N-methyltransferase	Rattus norvegicus	100-104
7037365-2	1981	This serotonin N-acetyltransferase inactivating substance enhances the thermal inactivation of the norepinephrine-stimulated serotonin N-acetyltransferase activity in rat pineal homogenate.	Norepinephrine	99-113	aralkylamine N-acetyltransferase	Rattus norvegicus	5-34
7037365-2	1981	This serotonin N-acetyltransferase inactivating substance enhances the thermal inactivation of the norepinephrine-stimulated serotonin N-acetyltransferase activity in rat pineal homogenate.	Norepinephrine	99-113	aralkylamine N-acetyltransferase	Rattus norvegicus	125-154
7219664-6	1981	Norepinephrine, injection into the lateral ventricle of the rabbit brain, stimulated the hydrolysis of the various 1,2-diacyl-, acylalkyl, and and acylalkenyl-glycerophosphatides by the phospholipase A2 from both glia and neurons.	Norepinephrine	0-14	phospholipase A2	Oryctolagus cuniculus	186-202
7202481-1	1980	After 7 day dosing with SK &amp; F 64139, an inhibitor of adrenal and CNS PNMT, a stoichiometric relationship is observed between epinephrine decrease and norepinephrine increase in adrenal tissue.	Norepinephrine	155-169	phenylethanolamine-N-methyltransferase	Rattus norvegicus	74-78
7459080-1	1980	Dopamine-beta-Hydroxylase is the enzyme that catalyzes the conversion of dopamine to norepinephrine.	Norepinephrine	85-99	dopamine beta-hydroxylase	Homo sapiens	0-25
6766787-0	1980	Increased dopamine and norepinephrine concentrations in primate CSF following amphetamine and phenylethylamine administration.	Norepinephrine	23-37	colony stimulating factor 2	Homo sapiens	64-67
6101988-3	1980	However, in the C-2-area, the epinephrine and norepinephrine stimulated cyclic AMP formation involved the activation of a single receptor type which was alpha-like in character.	Norepinephrine	46-60	complement C2	Rattus norvegicus	16-19
7362418-2	1980	Dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine to norepinephrine, was measured in the CSF of 32 subjects.	Norepinephrine	70-84	dopamine beta-hydroxylase	Homo sapiens	0-25
7362418-2	1980	Dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine to norepinephrine, was measured in the CSF of 32 subjects.	Norepinephrine	70-84	dopamine beta-hydroxylase	Homo sapiens	27-30
223726-1	1979	The present study was undertaken to identify the hypothalamic locus where norepinephrine (NE) nerve terminals communicate with luteinizing hormone-releasing hormone (LH-RH)-containing neurons involved in the stimulatory feedback action of gonadal steroids on LH and FSH release.	Norepinephrine	74-88	gonadotropin releasing hormone 1	Rattus norvegicus	166-171
476231-6	1979	Since DBH does not occur in dopamine neurons, it is likely that the psychological effects were due to changes in dopamine or norepinephrine in norepinephrine neurons.	Norepinephrine	143-157	dopamine beta-hydroxylase	Homo sapiens	6-9
458440-2	1979	The present study represents an effort to evaluate and to place in proper perspective data based on the DbetaH activity found in the region of the light vesicle peak of noradrenaline (NA), which is used as a quantitative measure of a population of small terminal vesicles.	Norepinephrine	169-182	dopamine beta-hydroxylase	Rattus norvegicus	104-110
44867-6	1979	The antidepressive action of ECT fits the amine hypothesis, ECT causes a sustained increase of the synthesis of norepinephrine and of the sensitivity of amine receptors and creates conditions for alleviating both "low-output" and "low-sensitivity" depression.	Norepinephrine	112-126	ECT	Homo sapiens	29-32
44867-6	1979	The antidepressive action of ECT fits the amine hypothesis, ECT causes a sustained increase of the synthesis of norepinephrine and of the sensitivity of amine receptors and creates conditions for alleviating both "low-output" and "low-sensitivity" depression.	Norepinephrine	112-126	ECT	Homo sapiens	60-63
29697-5	1978	Immunohistochemical localization of antibodies to dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) demonstrated that types of SIF cell localize antibodies to DBH but not PNMT, providing strong evidence that norepinephrine is the neurotransmitter for all the SIF cells of the guinea pig SCG.	Norepinephrine	240-254	phenylethanolamine N-methyltransferase	Cavia porcellus	126-130
29697-5	1978	Immunohistochemical localization of antibodies to dopamine-beta-hydroxylase (DBH) and phenylethanolamine-N-methyltransferase (PNMT) demonstrated that types of SIF cell localize antibodies to DBH but not PNMT, providing strong evidence that norepinephrine is the neurotransmitter for all the SIF cells of the guinea pig SCG.	Norepinephrine	240-254	dopamine beta-hydroxylase	Cavia porcellus	191-194
730257-0	1978	CSF norepinephrine in cerebrovascular accidents.	Norepinephrine	4-18	colony stimulating factor 2	Homo sapiens	0-3
84757-3	1978	Since the mature secretory granules in the Small Granule Chromaffin (SGC) cell were argentaffin and were mainly located along the cell membrane, this cell was clearly distinguishable under the light microscope both from the A (adrenaline) cell whose secretory granules were non-argentaffin and from the NA (noradrenaline) cell whose cytoplasm was rich and was filled with large, strongly argentaffin granules.	Norepinephrine	307-320	serglycin	Mus musculus	43-67
84757-3	1978	Since the mature secretory granules in the Small Granule Chromaffin (SGC) cell were argentaffin and were mainly located along the cell membrane, this cell was clearly distinguishable under the light microscope both from the A (adrenaline) cell whose secretory granules were non-argentaffin and from the NA (noradrenaline) cell whose cytoplasm was rich and was filled with large, strongly argentaffin granules.	Norepinephrine	307-320	serglycin	Mus musculus	69-72
25469-9	1978	These data suggest that cAMP mediates the effect of norepinephrine, which has been shown to diminish the change in pHi accompanying respiratory acidosis.	Norepinephrine	52-66	glucose-6-phosphate isomerase	Rattus norvegicus	115-118
580191-0	1978	Inhibition of cholinesterase by epinephrine and norepinephrine.	Norepinephrine	48-62	butyrylcholinesterase	Homo sapiens	14-28
639364-6	1978	All doses of met5-enkephalin amide (150,200 and 600 microgram) and morphine (134 and 200 microgram) increased the brain levels of 5-hydroxyindoleacetic acid, whereas only the large doses modified the levels of noradrenaline and serotonin.	Norepinephrine	210-223	proenkephalin	Rattus norvegicus	18-28
729942-0	1978	Action of norepinephrine on the serum gastrin level.	Norepinephrine	10-24	gastrin	Homo sapiens	38-45
729942-1	1978	The authors have studied the influence of endogenous norepinephrine released during exercise on the level of serum gastrin.	Norepinephrine	53-67	gastrin	Homo sapiens	115-122
756492-1	1978	Dopamine-beta-hydroxylase (DBH), an enzyme that catalyzes the conversion of dopamine (DA) to norepinephrine (NE) in adrenal medullary chromaffin granules, increases the electrical conductance of bimolecular lipid membranes.	Norepinephrine	93-107	dopamine beta-hydroxylase	Homo sapiens	0-25
756492-1	1978	Dopamine-beta-hydroxylase (DBH), an enzyme that catalyzes the conversion of dopamine (DA) to norepinephrine (NE) in adrenal medullary chromaffin granules, increases the electrical conductance of bimolecular lipid membranes.	Norepinephrine	93-107	dopamine beta-hydroxylase	Homo sapiens	27-30
201940-0	1977	Possible role of dopamine-beta-hydroxylase in the regulation of norepinephrine biosynthesis in rat brain.	Norepinephrine	64-78	dopamine beta-hydroxylase	Rattus norvegicus	17-42
201940-1	1977	In Experiment 1, the dose-response effects of three dopamine-beta-hydroxylase (DBH) inhibitors (diethyldithiocarbamate, FLA-63 and U-14, 624) on the endogenous levels of norepinephrine and dopamine in pons-medulla of rat brain were determined.	Norepinephrine	170-184	dopamine beta-hydroxylase	Rattus norvegicus	52-77
201940-1	1977	In Experiment 1, the dose-response effects of three dopamine-beta-hydroxylase (DBH) inhibitors (diethyldithiocarbamate, FLA-63 and U-14, 624) on the endogenous levels of norepinephrine and dopamine in pons-medulla of rat brain were determined.	Norepinephrine	170-184	dopamine beta-hydroxylase	Rattus norvegicus	79-82
201940-5	1977	The results from the three experiments are consistent with the idea that DBH is involved in the regulation of norepinephrine biosynthesis.	Norepinephrine	110-124	dopamine beta-hydroxylase	Rattus norvegicus	73-76
19952-1	1977	Catecholamines, especially norepinephrine and dopamine, as well as GABA extracted from porcine hypothalamic tissue, were found to possess PIF activity in vitro.	Norepinephrine	27-41	PIF1 5'-to-3' DNA helicase	Homo sapiens	138-141
1053066-1	1976	Study is presented of the effect of noradrenaline on thermic denaturation of DNA-total histone complexes within the range of protein concentrations which corresponds to c1/c2 0-1.7 in solutions of 10(-3) M Na+ ionic strength (c1 and c2 being the weight concentrations of protein and nucleic acid, respectively).	Norepinephrine	36-49	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	169-180
782312-3	1976	Dopamine-beta-hydroxylase, the enzyme responsible for conversion of dopamine to norepinephrine, is released along with catecholamines from the adrenal medulla and from sympathetic nerve endings.	Norepinephrine	80-94	dopamine beta-hydroxylase	Homo sapiens	0-25
782312-12	1976	Inhibition of dopamine-beta-hydroxylase provides a useful pharmacologic approach to evaluating the role of norepinephrine in psychiatric disorders.	Norepinephrine	107-121	dopamine beta-hydroxylase	Homo sapiens	14-39
954850-0	1976	Enkephalin: a potential modulator of noradrenaline release in rat brain.	Norepinephrine	37-50	proenkephalin	Rattus norvegicus	0-10
1033105-5	1976	2) TLP-607 slightly hypertension induced by dopamine, adrenaline and noradrenaline, but had no effect on hypotension induced by acetylcholine and histamine.	Norepinephrine	69-82	cysteine rich protein 3	Homo sapiens	3-6
1278114-3	1976	Dopamine, norepinephrine, and epinephrine were incubated with catechol-O-methyl transferase (COMT) and [3H]S-acenosyl methionine ([3H]SAM) and were converted to the O-methylated tritiated derivatives: [3H]methoxytyramine, [3H]normetanephrine, and [3H]metanephrine, respectively.	Norepinephrine	10-24	catechol-O-methyltransferase	Rattus norvegicus	62-91
4197-3	1976	The ratio between tyrosine hydroxylase and dopamine-beta-hydroxylase activities showed a significant correlation when compared with the ratio of dopamine and norepinephrine concentrations for the areas studied.	Norepinephrine	158-172	dopamine beta-hydroxylase	Rattus norvegicus	43-68
176346-5	1976	The time for aortic preparations from spontaneously hypertensive rats to relax to base-line tension after maximum contraction with norepinephrine, serotonin and potassium chloride was significantly prolonged compared to recovery time for vessels from Kyoto Wistar normotensive rats.	Norepinephrine	131-145	neurogenin 3	Rattus norvegicus	73-78
1244775-2	1976	The dissociation between transmitter release and enzyme release in the presence of cyclopropane may be the result of either an increase in the affinity of norepinephrine for binding sites on the vesicular membrane produced by cyclopropane, or a direct effect of cyclopropane on a mechanism of release of norepinephrine that could be controlled independently of release of dopamine-beta-hydroxylase.	Norepinephrine	155-169	dopamine beta-hydroxylase	Cavia porcellus	372-397
176694-17	1976	Further, a comparison of adenylate cyclase activities with norepinephrine binding yields a turnover number for the enzyme of the order of 10(-2) sec-1, assuming a 1:1 relationship between beta-adrenergic recptor and adenylate cyclase.	Norepinephrine	59-73	secretory blood group 1	Rattus norvegicus	145-150
1064147-0	1976	Effect of epinephrine and norepinephrine on gastrin release and gastric secretion of acid in man.	Norepinephrine	26-40	gastrin	Homo sapiens	44-51
1064147-3	1976	Norepinephrine in the low dose (n=11) caused a very small increase in gastrin release and no change in acid secretion, whereas the high dose (n=11) inhibited acid secretion without any change in gastrin concentration.	Norepinephrine	0-14	gastrin	Homo sapiens	70-77
1064147-5	1976	It is concluded that epinephrine and norepinephrine both may be of importance in the physiological regulation of gastrin release and gastric acid secretion.	Norepinephrine	37-51	gastrin	Homo sapiens	113-120
1233385-5	1975	A dopamine-beta-hydroxylase inhibitor, U-14, 624, depleted norepinephrine an additional 70% yet failed to alter self-stimulation in any of the groups.	Norepinephrine	59-73	dopamine beta-hydroxylase	Rattus norvegicus	2-27
1241912-3	1975	Since treatment of schizophrenic patients with disulfiram, an inhibitor of norepinephrine synthesis that acts at the level of the enzyme dopamine beta-hydroxylase, thereby leading to increased dopamine concentrations, had been found to profoundly exaggerate psychotic symptomatology, amphetamine behavioral syndrome in the cat as it is modified by pretreatment with disulfiram.	Norepinephrine	75-89	dopamine beta-hydroxylase	Homo sapiens	137-162
1100685-3	1975	DBH is the enzyme that catalyzes the conversion of dopamine to noradrenaline, and as such is useful as an anatomical marker for noradrenaline and possibly adrenaline neurons.	Norepinephrine	63-76	dopamine beta-hydroxylase	Rattus norvegicus	0-3
1100685-3	1975	DBH is the enzyme that catalyzes the conversion of dopamine to noradrenaline, and as such is useful as an anatomical marker for noradrenaline and possibly adrenaline neurons.	Norepinephrine	128-141	dopamine beta-hydroxylase	Rattus norvegicus	0-3
1237420-2	1975	It has been recently reported that plasma dopamine-beta-hydroxylase (DBH) excreted through the mechanism of the exocytosis with noradrenaline from the sympathetic postganglionic nervous endings is a mirror of the function of the sympathetic nervous system.	Norepinephrine	128-141	dopamine beta-hydroxylase	Homo sapiens	42-67
1237420-2	1975	It has been recently reported that plasma dopamine-beta-hydroxylase (DBH) excreted through the mechanism of the exocytosis with noradrenaline from the sympathetic postganglionic nervous endings is a mirror of the function of the sympathetic nervous system.	Norepinephrine	128-141	dopamine beta-hydroxylase	Homo sapiens	69-72
1111112-1	1975	Postmorten brain specimens from nine chronic schizophrenic patients and nine control were assayed for activity of dopamine beta-hydroxylase, the enzyme responsible for the conversion of dopamine to norepinephrine.	Norepinephrine	198-212	dopamine beta-hydroxylase	Homo sapiens	114-139
1150360-1	1975	Dopamine-beta-hydroxylase (DBH) the enzyme responsible for the biosynthesis of noradrenaline from dopamine, was assayed in the blood plasma of 19 cases with hypertension before and during beta-receptor blockade.	Norepinephrine	79-92	dopamine beta-hydroxylase	Homo sapiens	0-25
1150360-1	1975	Dopamine-beta-hydroxylase (DBH) the enzyme responsible for the biosynthesis of noradrenaline from dopamine, was assayed in the blood plasma of 19 cases with hypertension before and during beta-receptor blockade.	Norepinephrine	79-92	dopamine beta-hydroxylase	Homo sapiens	27-30
1151368-1	1975	The activity of dopamine-beta-hydroxylase, the enzyme that catalyzes the conversion of dopamine to norepinephrine, was measured in the serum of a strain of Wistar rats homozygous and heterozygous for a genetic form of hypothalamic diabetes insipidus and in Wistar control rats.	Norepinephrine	99-113	dopamine beta-hydroxylase	Rattus norvegicus	16-41
1145901-1	1975	Dopamine-beta-hydroxylase (DBH), the enzyme responsible for the biosynthesis of noradrenalin from dopamine, was assayed in the blood plasma of 20 men with primary hypertension.	Norepinephrine	80-92	dopamine beta-hydroxylase	Homo sapiens	0-25
1145901-1	1975	Dopamine-beta-hydroxylase (DBH), the enzyme responsible for the biosynthesis of noradrenalin from dopamine, was assayed in the blood plasma of 20 men with primary hypertension.	Norepinephrine	80-92	dopamine beta-hydroxylase	Homo sapiens	27-30
4805003-8	1973	However, addition of reduced ascorbic acid, the cosubstrate for dopamine beta-hydroxylase, markedly stimulated the conversion of dopamine (DA) to norepinephrine (NE).	Norepinephrine	146-160	dopamine beta-hydroxylase	Homo sapiens	64-89
4719906-1	1973	Postmortem brain specimens from 18 schizophrenic patients and 12 normal controls were assayed for dopamine-beta-hydroxylase (DBH), the enzyme responsible for the final step in norepinephrine biosynthesis.	Norepinephrine	176-190	dopamine beta-hydroxylase	Homo sapiens	98-123
4719906-1	1973	Postmortem brain specimens from 18 schizophrenic patients and 12 normal controls were assayed for dopamine-beta-hydroxylase (DBH), the enzyme responsible for the final step in norepinephrine biosynthesis.	Norepinephrine	176-190	dopamine beta-hydroxylase	Homo sapiens	125-128
5289380-1	1971	Dopamine-beta-hydroxylase (EC 1.14.2.1), an enzyme localized in sympathetic synaptic vesicles, was released together with norepinephrine during in vitro stimulation of the hypogastric nerve that innervates the vas deferens of the guinea pig.	Norepinephrine	122-136	dopamine beta-hydroxylase	Cavia porcellus	0-25
5289380-4	1971	These findings suggest that the release of the sympathetic neurotransmitter, norepinephrine, occurs by a process of exocytosis in which the vesicular content of soluble dopamine-beta-hydroxylase is also released.	Norepinephrine	77-91	dopamine beta-hydroxylase	Cavia porcellus	169-194
4930475-0	1971	Fusaric (5-butylpicolinic) acid, an inhibitor of dopamine beta-hydroxylase, affects serotonin and noradrenaline.	Norepinephrine	98-111	dopamine beta-hydroxylase	Homo sapiens	49-74
5121935-0	1971	[Action of catechol-O-methyltransferase on norepinephrine effects in rats adaptated to various temperatures].	Norepinephrine	43-57	catechol-O-methyltransferase	Rattus norvegicus	11-39
5472868-0	1970	Studies on central and peripheral noradrenaline neurons using a new dopamine-(beta)-hydroxylase inhibitor.	Norepinephrine	34-47	dopamine beta-hydroxylase	Homo sapiens	68-95
33990796-0	2021	APOE4 provokes tau aggregation via inhibition of noradrenaline transport.	Norepinephrine	49-62	microtubule associated protein tau	Homo sapiens	15-18
33904806-1	2021	OBJECTIVE: To determine the in vitro effects of epinephrine, norepinephrine, and dobutamine on lipopolysaccharide (LPS)-stimulated production of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-10 (IL-10) in blood from healthy dogs.	Norepinephrine	61-75	tumor necrosis factor	Canis lupus familiaris	145-172
33093660-0	2021	Binding pathway determines norepinephrine selectivity for the human beta1AR over beta2AR.	Norepinephrine	27-41	adenosine A2a receptor	Homo sapiens	81-88
33420473-5	2021	We further used lentivirus-mediated RNA interference to study the role of renalase in the progression of pathological ventricular hypertrophy and found that renalase inhibition attenuated the noradrenaline-induced hypertrophic response in vitro or the pressure overload-induced hypertrophic response in vivo.	Norepinephrine	192-205	renalase, FAD dependent amine oxidase	Homo sapiens	74-82
33420473-5	2021	We further used lentivirus-mediated RNA interference to study the role of renalase in the progression of pathological ventricular hypertrophy and found that renalase inhibition attenuated the noradrenaline-induced hypertrophic response in vitro or the pressure overload-induced hypertrophic response in vivo.	Norepinephrine	192-205	renalase, FAD dependent amine oxidase	Homo sapiens	157-165
33995135-1	2021	Dopamine-beta-hydroxylase (DbetaH) is an enzyme converting dopamine to norepinephrine, a key neurotransmitter in mood disorders, such as major depressive disorder (MDD) and bipolar disorder (BD).	Norepinephrine	71-85	dopamine beta-hydroxylase	Homo sapiens	0-25
33722543-8	2021	Consistent with previous in vivo observations in mice, ErbB4 deficiency led to increases in extracellular dopamine and norepinephrine levels.	Norepinephrine	119-133	erb-b2 receptor tyrosine kinase 4	Mus musculus	55-60
33850134-3	2021	Here, we employ the Drosophila melanogaster dopamine transporter as a surrogate for the norepinephrine transporter and determine X-ray structures of the transporter in its substrate-free and norepinephrine-bound forms.	Norepinephrine	191-205	Dopamine transporter	Drosophila melanogaster	44-64
33845730-3	2022	Such persistent HSC activation could be mediated by norepinephrine (NE), a reaction product of dopamine beta-hydroxylase (DBH).	Norepinephrine	52-66	dopamine beta-hydroxylase	Homo sapiens	95-120
33845730-3	2022	Such persistent HSC activation could be mediated by norepinephrine (NE), a reaction product of dopamine beta-hydroxylase (DBH).	Norepinephrine	52-66	dopamine beta-hydroxylase	Homo sapiens	122-125
33931975-5	2021	The role norepinephrine (NE) plays in AD remains complicated but pre-tangle tau has consistently been shown to arise in the locus coeruleus (LC) of patients with AD decades before symptom onset.	Norepinephrine	9-23	microtubule associated protein tau	Homo sapiens	76-79
33002334-6	2021	Norepinephrine or epinephrine were used in the presence of the beta2 -selective antagonist (ICI 118,551, 50nM) or the beta1 -selective antagonist (CGP 20712A, 300 nM) to stimulate beta1 -AR or beta2 -AR, respectively.	Norepinephrine	0-14	adenosine A2a receptor	Homo sapiens	193-202
33481407-16	2021	CONCLUSIONS: Our findings demonstrate that treatment with epinephrine or norepinephrine strongly reduces endothelial permeability induced by agonists of multiple Toll-like receptors (Toll-like receptor-2, Toll-like receptor-3, Toll-like receptor-4) in vitro.	Norepinephrine	73-87	toll like receptor 4	Homo sapiens	227-247
33055197-10	2020	Rln3 neurons project to the limbic cortex, septum, hippocampus, and hypothalamus, in a way that resembles the ascending brain systems expressing dopamine, serotonin, and norepinephrine.	Norepinephrine	170-184	relaxin 3	Homo sapiens	0-4
32246947-10	2020	When knockdown or overexpression of CerK was performed, Ca2+-induced release of [3H] noradrenaline was reduced or enhanced, respectively, but neurite extension was not modified.	Norepinephrine	85-98	ceramide kinase	Rattus norvegicus	36-40
32246947-11	2020	There was a positive correlation between noradrenaline release and formation of C1P and/or CerK-HA levels in NGF- and clasto-lactacystin-treated cells.	Norepinephrine	41-54	ceramide kinase	Rattus norvegicus	91-95
32894465-2	2020	The activity of noradrenaline synthesis enzymes tyrosine hydroxylase and dopamine-beta-hydroxylase was measured in the brain and adrenal glands 48 and 72 h after the injection of immunotoxin (anti-dopamine-beta-hydroxylase-saporin) into the rat brain ventricles.	Norepinephrine	16-29	dopamine beta-hydroxylase	Rattus norvegicus	73-98
32894465-2	2020	The activity of noradrenaline synthesis enzymes tyrosine hydroxylase and dopamine-beta-hydroxylase was measured in the brain and adrenal glands 48 and 72 h after the injection of immunotoxin (anti-dopamine-beta-hydroxylase-saporin) into the rat brain ventricles.	Norepinephrine	16-29	dopamine beta-hydroxylase	Rattus norvegicus	197-222
32253104-1	2020	Endogenous noradrenaline (NA) has multiple bioactive functions and, in the central nervous system (CNS), has been implicated in modulating neuroinflammation via beta-adrenergic receptors (beta-ARs).	Norepinephrine	11-24	alanyl-tRNA synthetase	Mus musculus	188-196
32493616-1	2020	BACKGROUND: Neuropeptide Y acts directly on the vasculature as a cotransmitter with norepinephrine for an augmented contraction.	Norepinephrine	84-98	neuropeptide Y	Homo sapiens	12-26
32070787-5	2020	Another major aspect of the hypothesis is that phenol or polyphenol molecules, found in various plants, may combine with particular fats or even ethanol to form dopamine, which can then be converted to norepinephrine through the already established step involving the enzyme dopamine beta-hydroxylase.	Norepinephrine	202-216	dopamine beta-hydroxylase	Homo sapiens	275-300
32244188-16	2020	Injections of norepinephrine into the ArcPomc-/- female mice reduced circulating adiponectin levels, whereas injections of propranolol significantly increased adiponectin levels.	Norepinephrine	14-28	adiponectin, C1Q and collagen domain containing	Mus musculus	81-92
32332538-8	2020	RESULTS: Grafts treated by extracellular vesicles derived from adipose-derived stem cells showed enhanced beige adipose regeneration with increased neovascularization, M2 macrophage proportion, and norepinephrine secretion at postgraft week 4.	Norepinephrine	198-212	WD and tetratricopeptide repeats 1	Mus musculus	63-70
31995740-5	2020	In addition, the dynamic transition of the polarization spectrum from C6 to C3v line profile was observed in a cell culture in which norepinephrine induced an alpha- to beta-myosin transition.	Norepinephrine	133-147	myosin heavy chain 14	Homo sapiens	174-180
31940997-7	2020	Matured hop bitter acids (MHBAs), oxidized components with beta-carbonyl moieties derived from aged hops, also enhance memory functions via norepinephrine neurotransmission-mediated mechanisms.	Norepinephrine	140-154	HOP homeobox	Homo sapiens	8-11
31771069-3	2020	Catechol-O-methyltransferase (COMT) and monoamine oxidase B (MAOB) are the enzymes that regulate degradation of dopamine, while dopamine beta-hydroxylase (DBH) is involved in synthesis of noradrenaline.	Norepinephrine	188-201	dopamine beta-hydroxylase	Homo sapiens	128-153
31771069-3	2020	Catechol-O-methyltransferase (COMT) and monoamine oxidase B (MAOB) are the enzymes that regulate degradation of dopamine, while dopamine beta-hydroxylase (DBH) is involved in synthesis of noradrenaline.	Norepinephrine	188-201	dopamine beta-hydroxylase	Homo sapiens	155-158
31613389-1	2020	Dopamine beta-hydroxylase (DbetaH) is an essential neurotransmitter-synthesizing enzyme that catalyzes the formation of norepinephrine (NE) from dopamine and has been extensively studied since its discovery in the 1950s.	Norepinephrine	120-134	dopamine beta-hydroxylase	Homo sapiens	0-25
31891756-4	2019	It was hypothesised that NAT would be expressed exclusively on nerve fibres labelled by dopamine beta hydroxylase (DbetaH), an enzyme involved in the conversion of dopamine to noradrenaline.	Norepinephrine	176-189	dopamine beta-hydroxylase	Rattus norvegicus	88-113
32186162-10	2019	Finally, we find that kidney invigoration method can change the concentrations of central neurotransmitters of norepinephrine and glutamate to regulate neuro-osteogenic network, and promote the recovery of ovarian function and have an estrogen-like effect by regulating the hypothalamus-pituitary-ovarian axis, which thus influences bone metabolism without clinically significant estrogen-like side effects, and regulate NPY, CGRP and SP involved in the bone metabolism.	Norepinephrine	111-125	neuropeptide Y	Homo sapiens	421-424
31344438-6	2019	D1870-mediated enhancement of PLN Ser16 phosphorylation was also observed after exposure to isoprenaline or noradrenaline (NA) stimuli that do not activate RSK.	Norepinephrine	108-121	phospholamban	Rattus norvegicus	30-33
31831958-2	2019	Molecular dynamics simulation (MDS) and docking analysis of biogenic monoamines with ceruloplasmin explain the role of Asp1025, Glu935, Glu272, Glu232 and Glu230 together with the binding site water molecules (referred as conserved water molecules) in the stabilization of neurotransmitter (Serotonin, Norepinephrine and Epinephrine) molecules within the binding cavity of hCP.	Norepinephrine	302-316	ceruloplasmin	Homo sapiens	85-98
31484844-3	2019	More recently, we have revealed that a selective eEF2K inhibitor, A484954 induced vasorelaxation via opening inward rectifier K+ channel and activating beta2-adrenergic receptor in smooth muscle of rat isolated mesenteric artery, which contributes to prevent noradrenaline-induced acute increase in blood pressure (BP).	Norepinephrine	259-272	eukaryotic elongation factor-2 kinase	Rattus norvegicus	49-54
31631645-5	2019	The comparison among the ischemic group vs Br preconditioned (P&lt;0.05), and Nor preconditioned (P&lt;0.001) groups after 48 h of reperfusion, showed statistically significant decrease of Mn-SOD activity.	Norepinephrine	78-81	SOD-2	Oryctolagus cuniculus	189-195
31339804-4	2019	In contrast, hypothalamic-specific ablation of Fgf13 recapitulated weight gain at 30 C. Norepinephrine turnover in brown fat was reduced at both housing temperatures.	Norepinephrine	88-102	fibroblast growth factor 13	Mus musculus	47-52
31603552-12	2019	The low levels of ARG, homoarginine, and citrulline may be the consequence of high circulating levels of alpha1 -agonists, such as epinephrine and norepinephrine, and their biochemical interaction with endothelial trace amine-associated receptor 1 that induces activation of NO synthase, resulting in NO synthesis in the circulation, NO release, intense vasodilation, and as a result, the cluster attack.	Norepinephrine	147-161	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	18-21
31237989-6	2019	Moreover, metabolomic analysis reveals that serum norepinephrine (NE) and isovalerate levels are significantly increased in response to PW5 intervention, with decreased serum levels of acetylcholine (AChe) and valerate, compared with the vehicle-treated APP/PS1 mice.	Norepinephrine	50-64	presenilin 1	Mus musculus	258-261
30894696-7	2019	Urinary L-DOPA and noradrenaline levels were significantly increased in sik1-/- mice fed a high-salt diet as compared with sik1-/- mice on a control diet.	Norepinephrine	19-32	salt inducible kinase 1	Mus musculus	72-76
30894696-8	2019	Similarly, the activity of dopamine beta-hydroxylase (DbetaH), the enzyme that converts dopamine to noradrenaline, was significantly increased in the adrenal glands of sik1-/- mice on a high-salt intake compared with sik1+/+ and sik1-/- mice on a control diet.	Norepinephrine	100-113	salt inducible kinase 1	Mus musculus	168-172
30651588-6	2019	In the adrenal glands of adult SHR, the expression of catecholamine biosynthetic enzymes Th, Ddc, Dbh and Pnmt was decreased along the amounts of dopamine and noradrenaline (50% and 38%, respectively, p < 0.001).	Norepinephrine	159-172	dopamine beta-hydroxylase	Rattus norvegicus	98-101
30651588-6	2019	In the adrenal glands of adult SHR, the expression of catecholamine biosynthetic enzymes Th, Ddc, Dbh and Pnmt was decreased along the amounts of dopamine and noradrenaline (50% and 38%, respectively, p < 0.001).	Norepinephrine	159-172	phenylethanolamine-N-methyltransferase	Rattus norvegicus	106-110
31528826-0	2019	Dipeptidyl Peptidase 4 Inhibition Increases Postprandial Norepinephrine via Substance P (NK1 Receptor) During RAAS Inhibition.	Norepinephrine	57-71	dipeptidyl peptidase 4	Homo sapiens	0-22
31528826-0	2019	Dipeptidyl Peptidase 4 Inhibition Increases Postprandial Norepinephrine via Substance P (NK1 Receptor) During RAAS Inhibition.	Norepinephrine	57-71	tachykinin receptor 1	Homo sapiens	89-101
31528826-12	2019	During treatment with an ACE inhibitor or angiotensin receptor blocker, DPP4 inhibition increased postprandial norepinephrine through a substance P receptor-dependent mechanism.	Norepinephrine	111-125	dipeptidyl peptidase 4	Homo sapiens	72-76
31528826-12	2019	During treatment with an ACE inhibitor or angiotensin receptor blocker, DPP4 inhibition increased postprandial norepinephrine through a substance P receptor-dependent mechanism.	Norepinephrine	111-125	tachykinin receptor 1	Homo sapiens	136-156
31242414-7	2019	Moreover, the sympathetic neurotransmitter norepinephrine could inhibit the LPS-elicited innate immunity cell-intrinsically via beta2-adrenergic receptor signaling.	Norepinephrine	43-57	adrenergic receptor, beta 2	Mus musculus	128-153
30917654-0	2019	Binding of Noradrenaline to Native and Intermediate States during the Fibrillation of alpha-Synuclein Leads to the Formation of Stable and Structured Cytotoxic Species.	Norepinephrine	11-24	synuclein alpha	Homo sapiens	86-101
31178828-2	2019	Here, I review findings from mouse studies on the direct modulation of GnRH neuron activity and GnRH secretion by non-peptide neurotransmitters (GABA, glutamate, dopamine, serotonin, norepinephrine, epinephrine, histamine, ATP, adenosine, and acetylcholine), gasotransmitters (nitric oxide and carbon monoxide), and gliotransmitters (prostaglandin E2 and possibly GABA, glutamate, and ATP).	Norepinephrine	183-197	gonadotropin releasing hormone 1	Mus musculus	71-75
31178828-2	2019	Here, I review findings from mouse studies on the direct modulation of GnRH neuron activity and GnRH secretion by non-peptide neurotransmitters (GABA, glutamate, dopamine, serotonin, norepinephrine, epinephrine, histamine, ATP, adenosine, and acetylcholine), gasotransmitters (nitric oxide and carbon monoxide), and gliotransmitters (prostaglandin E2 and possibly GABA, glutamate, and ATP).	Norepinephrine	183-197	gonadotropin releasing hormone 1	Mus musculus	96-100
29498170-1	2019	The alpha1 -adrenergic antagonist, doxazosin, has improved cocaine use disorder (CUD) presumably by blocking norepinephrine (NE) stimulation and reward from cocaine-induced NE increases.	Norepinephrine	109-123	adrenoceptor alpha 1D	Homo sapiens	4-10
30703415-1	2019	alpha2-adrenoceptor (alpha2-AR) isoforms, abundant in sympathetic synapses and noradrenergic neurons of the central nervous system, are integral in the presynaptic feed-back loop mechanism that moderates norepinephrine surges.	Norepinephrine	204-218	adenosine A2a receptor	Homo sapiens	21-30
30759876-4	2019	This uncoupling protein 1 (UCP1)-mediated process requires input from sympathetic nerves releasing norepinephrine.	Norepinephrine	99-113	uncoupling protein 1	Homo sapiens	5-25
30759876-4	2019	This uncoupling protein 1 (UCP1)-mediated process requires input from sympathetic nerves releasing norepinephrine.	Norepinephrine	99-113	uncoupling protein 1	Homo sapiens	27-31
31304429-4	2019	The biogenic aldehydes produced from dopamine, norepinephrine and serotonin are known to be toxic, generate reactive oxygen species and/or cause aggregation of proteins such as alpha-synuclein.	Norepinephrine	47-61	synuclein alpha	Homo sapiens	177-192
30510101-3	2019	In the study described here, the noradrenergic system was found to be suppressed with decreased levels of norepinephrine (NE) in brains of infected animals and in infected human and rat neural cells in vitro The mechanism responsible for the NE suppression was found to be downregulation of dopamine beta-hydroxylase (DBH) gene expression, encoding the enzyme that synthesizes norepinephrine from dopamine, with downregulation observed in vitro and in infected brain tissue, particularly in the dorsal locus coeruleus/pons region.	Norepinephrine	106-120	dopamine beta-hydroxylase	Rattus norvegicus	291-316
30510101-3	2019	In the study described here, the noradrenergic system was found to be suppressed with decreased levels of norepinephrine (NE) in brains of infected animals and in infected human and rat neural cells in vitro The mechanism responsible for the NE suppression was found to be downregulation of dopamine beta-hydroxylase (DBH) gene expression, encoding the enzyme that synthesizes norepinephrine from dopamine, with downregulation observed in vitro and in infected brain tissue, particularly in the dorsal locus coeruleus/pons region.	Norepinephrine	106-120	dopamine beta-hydroxylase	Rattus norvegicus	318-321
31029854-10	2019	Doxycycline-induced tetNGN3-HIEs secreted serotonin, monocyte chemoattractant protein-1, glucose-dependent insulinotropic peptide, peptide YY, and ghrelin in response to norepinephrine and rotavirus infection, further supporting the presence of multiple EEC types.	Norepinephrine	170-184	C-C motif chemokine ligand 2	Homo sapiens	53-87
30043181-2	2018	After the demonstrations that both cardiac neuronal and extraneuronal MAO-A contribute to the degradation of norepinephrine and serotonin, several studies attempted to determine the impact of MAO-A activity in the control of local concentration of the two biogenic amines and in their receptor-mediated effects.	Norepinephrine	109-123	monoamine oxidase A	Homo sapiens	70-75
29478130-0	2018	CCL2 Induces the Production of beta2 Adrenergic Receptors and Modifies Astrocytic Responses to Noradrenaline.	Norepinephrine	95-108	C-C motif chemokine ligand 2	Rattus norvegicus	0-4
29478130-3	2018	Our previous studies of the mechanisms involved in this process indicate that noradrenaline induces the production of the chemokine CCL2 in astrocytes.	Norepinephrine	78-91	C-C motif chemokine ligand 2	Rattus norvegicus	132-136
29478130-4	2018	While CCL2 can protect neurons against certain injuries, its overproduction has also proven to be harmful and to prevent noradrenaline neuroprotective effects.	Norepinephrine	121-134	C-C motif chemokine ligand 2	Rattus norvegicus	6-10
29478130-5	2018	Therefore, in this study, we analyze if the modifications caused to astrocytes by an excessive production of CCL2 may alter their response to noradrenaline.	Norepinephrine	142-155	C-C motif chemokine ligand 2	Rattus norvegicus	109-113
29478130-8	2018	Furthermore, although CCL2 potentiates noradrenaline induction of glycogenolysis, this does not translate into an augmented release of lactate, one of the processes through which astrocytes help support neurons.	Norepinephrine	39-52	C-C motif chemokine ligand 2	Rattus norvegicus	22-26
29478130-9	2018	Additionally, other neuroprotective actions of noradrenaline, such as the production of brain derived neurotrophic factor and the inhibition of the inducible nitric oxide synthase in astrocytes were modified by CCL2.	Norepinephrine	47-60	C-C motif chemokine ligand 2	Rattus norvegicus	211-215
29478130-10	2018	These data suggest that some of the central nervous system alterations related to CCL2 could be due to its effects on adrenergic receptors and its interference with noradrenaline signaling.	Norepinephrine	165-178	C-C motif chemokine ligand 2	Rattus norvegicus	82-86
30192450-3	2018	The antidepressant duloxetine, acting as a serotonin-norepinephrine reuptake inhibitor, is mainly metabolized via CYP1A2.	Norepinephrine	53-67	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	114-120
30171520-0	2018	Correction to: Resveratrol attenuates norepinephrine-induced ovarian cancer invasiveness through downregulating hTERT expression.	Norepinephrine	38-52	telomerase reverse transcriptase	Homo sapiens	112-117
29987109-2	2018	NPY (neuropeptide Y) is coreleased with norepinephrine, causes vasoconstriction via the Y1 receptor, and is degraded by DPP4 to NPY (3-36) in vitro.	Norepinephrine	40-54	neuropeptide Y	Homo sapiens	0-3
29987109-2	2018	NPY (neuropeptide Y) is coreleased with norepinephrine, causes vasoconstriction via the Y1 receptor, and is degraded by DPP4 to NPY (3-36) in vitro.	Norepinephrine	40-54	neuropeptide Y	Homo sapiens	5-19
29987109-3	2018	NPY (3-36) decreases release of norepinephrine via the Y2 receptor.	Norepinephrine	32-46	neuropeptide Y	Homo sapiens	0-3
29935188-5	2018	Norepinephrine content and concentration were reduced depending on the treatment regimen, with a rank order of deficits of PN7-9 &gt; PN1-3 &gt; GD17-19.	Norepinephrine	0-14	serpin family E member 2	Rattus norvegicus	134-139
30125310-6	2018	Plasma norepinephrine and epinephrine concentrations were significantly higher in patients with oral and oropharyngeal squamous cell carcinoma (SCC) compared to non-cancer patients.	Norepinephrine	7-21	serpin family B member 3	Homo sapiens	144-147
30125310-7	2018	Oral SCC patients displayed plasma norepinephrine levels about six times higher than oropharyngeal SCC patients, and nine times higher than oral leukoplakia patients (p &lt; .001).	Norepinephrine	35-49	serpin family B member 3	Homo sapiens	5-8
30125310-9	2018	Oropharyngeal SCC patients had higher plasma norepinephrine (p = .0382) and epinephrine levels (p = .045) than patients with oral leukoplakia.	Norepinephrine	45-59	serpin family B member 3	Homo sapiens	14-17
30125310-10	2018	Multiple regression analyses showed that a history of high alcohol consumption was predictive for reduced plasma norepinephrine levels in the oral SCC group (p &lt; .001).	Norepinephrine	113-127	serpin family B member 3	Homo sapiens	147-150
30125310-11	2018	Anxiety symptom of "hand tremor" measured by the BAI was an independent predictor for higher plasma norepinephrine levels in HNSCC patients (beta = 157.5, p = .0377), while the "heart pounding/racing" symptom was independently associated with higher plasma epinephrine levels in the oropharyngeal SCC group (beta = 15.8, p = .0441).	Norepinephrine	100-114	serpin family B member 3	Homo sapiens	127-130
29570827-4	2018	In this study, we show that mitochondrial fission factor (MFF) is up-regulated upon hypertrophic agonist noradrenaline (NA) treatment.	Norepinephrine	105-118	mitochondrial fission factor	Rattus norvegicus	28-56
29570827-4	2018	In this study, we show that mitochondrial fission factor (MFF) is up-regulated upon hypertrophic agonist noradrenaline (NA) treatment.	Norepinephrine	105-118	mitochondrial fission factor	Rattus norvegicus	58-61
29875227-5	2018	TAS-303 [4-piperidinyl 2,2-diphenyl-2-(propoxy-1,1,2,2,3,3,3-day7 )acetate hydrochloride] is a novel small-molecule selective norepinephrine reuptake inhibitor that displays significant norepinephrine transporter (NET) inhibitory activity toward the serotonin or dopamine transporters.	Norepinephrine	126-140	solute carrier family 6 member 2	Rattus norvegicus	186-212
29875227-5	2018	TAS-303 [4-piperidinyl 2,2-diphenyl-2-(propoxy-1,1,2,2,3,3,3-day7 )acetate hydrochloride] is a novel small-molecule selective norepinephrine reuptake inhibitor that displays significant norepinephrine transporter (NET) inhibitory activity toward the serotonin or dopamine transporters.	Norepinephrine	126-140	solute carrier family 6 member 2	Rattus norvegicus	214-217
29758252-8	2018	In contrast, selective noradrenaline reuptake inhibitor desipramine had a significant effect on RGS8tg in the FST.	Norepinephrine	23-36	regulator of G-protein signaling 8	Mus musculus	96-100
29867144-3	2018	Copper imaging and gene expression analysis in zebrafish identifies the locus coeruleus-norepinephrine (LC-NE) system, a vertebrate-specific neuromodulatory circuit critical for regulating sleep, arousal, attention, memory and emotion, as a copper-enriched unit with high levels of copper transporters CTR1 and ATP7A and the copper enzyme dopamine beta-hydroxylase (DBH) that produces NE.	Norepinephrine	88-102	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	Danio rerio	366-369
29962965-10	2018	SBE 13 and cyclapolin 9 inhibited contractions by the alpha1-agonists methoxamine, phenylephrine, and noradrenaline.	Norepinephrine	102-115	adrenoceptor alpha 1D	Homo sapiens	54-60
29478144-7	2018	The MAOA gene encodes an enzyme which is involved in the catabolism of dopamine, norepinephrine, serotonin, and other monoaminergic neurotransmitters.	Norepinephrine	81-95	monoamine oxidase A	Homo sapiens	4-8
29424419-11	2018	PNMT and VGluT2 co-occur in some pre-synaptic terminals indicating the potential for co-transmission of glutamate and norepinephrine.	Norepinephrine	118-132	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-4
29424419-11	2018	PNMT and VGluT2 co-occur in some pre-synaptic terminals indicating the potential for co-transmission of glutamate and norepinephrine.	Norepinephrine	118-132	solute carrier family 17 member 6	Rattus norvegicus	9-15
29186431-2	2018	Monoamine oxidase A is one of the key enzymes mediating the turnover of noradrenaline.	Norepinephrine	72-85	monoamine oxidase A	Homo sapiens	0-19
29355945-0	2018	Essential role of hippocampal noradrenaline in the regulation of spatial working memory and TDP-43 tissue pathology.	Norepinephrine	30-43	TAR DNA binding protein	Rattus norvegicus	92-98
29496660-2	2018	Activation of beta3-adrenoceptors by sympathetic nerve-derived NA (noradrenaline) may be implicated in this effect and may stimulate the release of the vasodilator adiponectin from adipocytes.	Norepinephrine	67-80	adiponectin, C1Q and collagen domain containing	Mus musculus	164-175
29318546-3	2018	We here describe detailed methodology for the detection of pro- and active- forms of both MMP-2 (gelatinase A) and MMP-9 (gelatinase B) in cells using norepinephrine-stimulated H9c2 cardiomyoblasts as model.	Norepinephrine	151-165	matrix metallopeptidase 9	Homo sapiens	115-120
28888989-0	2017	Noradrenaline, oxymetazoline and phorbol myristate acetate induce distinct functional actions and phosphorylation patterns of alpha1A-adrenergic receptors.	Norepinephrine	0-13	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	126-133
28830684-7	2017	In addition, the treatment of norepinephrine (NE) to in vitro cardiomyocytes increased Axud1 level and induced cell apoptosis.	Norepinephrine	30-44	cysteine and serine rich nuclear protein 1	Rattus norvegicus	87-92
27836486-1	2017	Vesicular monoamine transporter 2 (VMAT2, SLC18A2) is a transmembrane transporter protein that packages dopamine, serotonin, norepinephrine, and histamine into vesicles in preparation for neurotransmitter release from the presynaptic neuron.	Norepinephrine	125-139	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	0-33
28598954-6	2017	RESULTS: Noradrenaline treatment resulted in a pronounced increase in SGLT2 and interleukin (IL)-6 expression in HK2 cells and promoted translocation of SGLT2 to the cell surface.	Norepinephrine	9-22	solute carrier family 5 (sodium/glucose cotransporter), member 2	Mus musculus	70-75
28598954-6	2017	RESULTS: Noradrenaline treatment resulted in a pronounced increase in SGLT2 and interleukin (IL)-6 expression in HK2 cells and promoted translocation of SGLT2 to the cell surface.	Norepinephrine	9-22	solute carrier family 5 (sodium/glucose cotransporter), member 2	Mus musculus	153-158
28598954-8	2017	SGLT2 inhibition significantly reduced high-fat diet-induced elevations of tyrosine hydroxylase and noradrenaline in the kidney and heart.	Norepinephrine	100-113	solute carrier family 5 (sodium/glucose cotransporter), member 2	Mus musculus	0-5
28855875-4	2017	Both alpha2C- and alpha2A-AR share autoreceptor functions to exert negative feedback control on noradrenaline (NA) release, with alpha2C-AR heteroreceptors regulating non-noradrenergic transmission (e.g., serotonin, dopamine).	Norepinephrine	96-109	adrenoceptor alpha 2A	Homo sapiens	18-28
28569366-15	2017	Since BPS/IC patients present high levels of noradrenaline, alpha 1A stimulation may be an additional trigger for bladder dysfunction presented by these patients.	Norepinephrine	45-58	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	60-68
28472693-8	2017	In the CRH group, the total increase of sAA activity significantly correlated with noradrenaline release, indicating that sAA activity reflects pharmacologically induced sympathetic activation.	Norepinephrine	83-96	amylase alpha 1A	Homo sapiens	40-43
28473352-0	2017	miR-21 is involved in norepinephrine-mediated rat granulosa cell apoptosis by targeting SMAD7.	Norepinephrine	22-36	microRNA 21	Rattus norvegicus	0-6
28430139-5	2017	In addition, noradrenaline, the major neurotransmitter of the sympathetic nervous system, results in elevated Adam28 mRNA expression in human monocytes.	Norepinephrine	13-26	ADAM metallopeptidase domain 28	Homo sapiens	110-116
27860160-6	2017	CPAP treatment decreased norepinephrine levels while the 24-hour profiles of growth hormone and cortisol remained unchanged.	Norepinephrine	25-39	centromere protein J	Homo sapiens	0-4
27923568-7	2017	Noradrenaline also increased CX3CL1 in its soluble form despite the inhibition of the activity and synthesis of ADAM10 and ADAM17, the main proteases known to cleave CX3CL1 from the neuronal membrane.	Norepinephrine	0-13	ADAM metallopeptidase domain 17	Homo sapiens	123-129
27951473-6	2017	In anaesthetized 7-week-old male Sprague-Dawley rats, the OA (3.8 mg of intravenous injection)-induced increase in plasma noradrenaline secretion was suppressed by TRPA1 or TRPV1 antagonist and by a beta2- or beta3-adrenoceptor antagonist.	Norepinephrine	122-135	adrenoceptor beta 3	Rattus norvegicus	209-227
27237101-0	2017	Beta-adrenoceptor Activation by Norepinephrine Enhances Lipopolysaccharide-induced Matrix Metalloproteinase-9 Expression Through the ERK/JNK-c-Fos Pathway in Human THP-1 Cells.	Norepinephrine	32-46	matrix metallopeptidase 9	Homo sapiens	83-109
27237101-0	2017	Beta-adrenoceptor Activation by Norepinephrine Enhances Lipopolysaccharide-induced Matrix Metalloproteinase-9 Expression Through the ERK/JNK-c-Fos Pathway in Human THP-1 Cells.	Norepinephrine	32-46	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	141-146
27694974-1	2016	Indatraline is an antidepressive agent and a non-selective monoamine transporter inhibitor that blocks the reuptake of neurotransmitters (dopamine, serotonin, and norepinephrine).	Norepinephrine	163-177	solute carrier family 18 member A2	Rattus norvegicus	59-80
27372867-5	2016	Changes in microcirculatory flow, by altering the flow mediated effect of plasma noradrenaline, are mainly responsible for altering the noradrenergic balance in the peripheral tissues; changes in CSF flow are speculated to be mainly responsible for doing the same in the brain, by altering the balance between synaptic noradrenaline in the brain and nonsynaptic noradrenaline in the subarachnoid CSF.	Norepinephrine	319-332	colony stimulating factor 2	Canis lupus familiaris	196-199
27372867-5	2016	Changes in microcirculatory flow, by altering the flow mediated effect of plasma noradrenaline, are mainly responsible for altering the noradrenergic balance in the peripheral tissues; changes in CSF flow are speculated to be mainly responsible for doing the same in the brain, by altering the balance between synaptic noradrenaline in the brain and nonsynaptic noradrenaline in the subarachnoid CSF.	Norepinephrine	319-332	colony stimulating factor 2	Canis lupus familiaris	196-199
27320040-4	2016	Using multiple hPSC reporter lines, we recapitulated human autonomic neuron development in vitro and successfully isolated PHOX2B::eGFP+ neurons that exhibit sympathetic marker expression and electrophysiological properties and norepinephrine secretion.	Norepinephrine	228-242	paired like homeobox 2B	Homo sapiens	123-129
27301276-14	2016	It decreases the contractile response of (-)-noradrenaline through the alpha2B-AR subtype, blocks the function of alpha2A-AR subtype and alters the G protein coupling of these receptors, promoting a Gs-dependent pathway.	Norepinephrine	41-58	adrenoceptor alpha 2B	Rattus norvegicus	71-81
27043247-0	2016	Dysregulation of Norepinephrine Release in the Absence of Functional Synaptotagmin 7.	Norepinephrine	17-31	synaptotagmin VII	Mus musculus	69-84
27043247-1	2016	Synaptotagmin 7 (Syt7) is expressed in cardiac sympathetic nerve terminals where norepinephrine (NE) is released in both Ca(2+)-dependent exocytosis and Ca(2+)-independent norepinephrine transporter (NET)-mediated overflow.	Norepinephrine	81-95	synaptotagmin VII	Mus musculus	0-15
27043247-1	2016	Synaptotagmin 7 (Syt7) is expressed in cardiac sympathetic nerve terminals where norepinephrine (NE) is released in both Ca(2+)-dependent exocytosis and Ca(2+)-independent norepinephrine transporter (NET)-mediated overflow.	Norepinephrine	81-95	synaptotagmin VII	Mus musculus	17-21
27190169-6	2016	Inasmuch as they increase synaptic dopamine levels, dopamine transporter (DAT) inhibitors, whether they are selective or have actions on noradrenaline or serotonin transporters, theoretically represent an attractive way to alleviate parkinsonism per se and potentially enhance l-DOPA antiparkinsonian action (provided that sufficient dopamine terminals remain within the striatum).	Norepinephrine	137-150	solute carrier family 6 member 3	Homo sapiens	52-72
27190169-6	2016	Inasmuch as they increase synaptic dopamine levels, dopamine transporter (DAT) inhibitors, whether they are selective or have actions on noradrenaline or serotonin transporters, theoretically represent an attractive way to alleviate parkinsonism per se and potentially enhance l-DOPA antiparkinsonian action (provided that sufficient dopamine terminals remain within the striatum).	Norepinephrine	137-150	solute carrier family 6 member 3	Homo sapiens	74-77
26257064-4	2016	Increased metabolites, PTGS2 and PTGES protein levels were found in Skov3-ip1 and HeyA8 cells treated with norepinephrine (NE), and these changes were shown to be mediated by ADRB2 receptor signaling.	Norepinephrine	107-121	prostaglandin E synthase	Homo sapiens	33-38
26257064-4	2016	Increased metabolites, PTGS2 and PTGES protein levels were found in Skov3-ip1 and HeyA8 cells treated with norepinephrine (NE), and these changes were shown to be mediated by ADRB2 receptor signaling.	Norepinephrine	107-121	adrenoceptor beta 2	Homo sapiens	175-180
26572541-1	2016	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of catecholamines and TH immunoreactivity is indicative of cells synthesising either adrenaline/noradrenaline or dopamine.	Norepinephrine	167-180	tyrosine hydroxylase	Danio rerio	0-20
26572541-1	2016	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of catecholamines and TH immunoreactivity is indicative of cells synthesising either adrenaline/noradrenaline or dopamine.	Norepinephrine	167-180	tyrosine hydroxylase	Danio rerio	93-95
26572539-4	2016	Adrenomedullary content of the secreted adrenal catecholamines norepinephrine (NE) and epinephrine (EPI) was decreased 30-40 % in Chga-KO mice.	Norepinephrine	63-77	chromogranin A	Mus musculus	130-134
26842107-2	2016	This paper describes the protocol for a randomised controlled trial (MIR) to investigate the extent to which the addition of the antidepressant mirtazapine is effective in reducing the symptoms of depression compared with placebo in patients who are still depressed after they have been treated with a selective serotonin reuptake inhibitor (SSRI) or serotonin and noradrenaline reuptake inhibitor (SNRI) for at least 6 weeks in primary care.	Norepinephrine	365-378	membrane associated ring-CH-type finger 8	Homo sapiens	69-72
26536590-7	2015	Ang-(1-7) via Mas receptor also inhibited both Angiotensin II- and noradrenaline/norephinephrine-induced transactivation of ErbB2 and/or EGFR receptors.	Norepinephrine	67-80	angiogenin	Rattus norvegicus	0-8
26536590-7	2015	Ang-(1-7) via Mas receptor also inhibited both Angiotensin II- and noradrenaline/norephinephrine-induced transactivation of ErbB2 and/or EGFR receptors.	Norepinephrine	67-80	erb-b2 receptor tyrosine kinase 2	Rattus norvegicus	124-129
26536590-7	2015	Ang-(1-7) via Mas receptor also inhibited both Angiotensin II- and noradrenaline/norephinephrine-induced transactivation of ErbB2 and/or EGFR receptors.	Norepinephrine	67-80	epidermal growth factor receptor	Rattus norvegicus	137-141
26277325-0	2015	Reduction in renal blood flow following administration of norepinephrine and phenylephrine in septic rats treated with Kir6.1 ATP-sensitive and KCa1.1 calcium-activated K+ channel blockers.	Norepinephrine	58-72	potassium inwardly-rectifying channel, subfamily J, member 8	Rattus norvegicus	119-125
26058426-6	2015	Mice treated with norepinephrine, displayed an increased number of metastatic foci of DU145 cells in inguinal lymph nodes and also showed an increased expression of MMP2 and MMP9 in tumor samples compared to controls.	Norepinephrine	18-32	matrix metallopeptidase 9	Homo sapiens	174-178
25728347-10	2015	Propranolol inhibited norepinephrine-induced cell invasion by reducing the expression of MMP-9, VEGF, and p-cofilin.	Norepinephrine	22-36	matrix metallopeptidase 9	Homo sapiens	89-94
25728347-11	2015	NO and VEGF release induced by norepinephrine was decreased by propranolol pretreatment, coincident with alterations in the phosphorylation of Akt, eNOS, and VEGFR-2.	Norepinephrine	31-45	kinase insert domain receptor	Homo sapiens	158-165
25916729-9	2015	In addition, Ad.PRSx8-mCherry/CAPON also reduced (3)H-norepinephrine release from spontaneously hypertensive rat atria (n=7).	Norepinephrine	54-68	nitric oxide synthase 1 adaptor protein	Rattus norvegicus	30-35
25151968-0	2015	hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness.	Norepinephrine	15-29	snail family transcriptional repressor 2	Homo sapiens	38-42
25437118-7	2015	In vitro, norepinephrine up-regulated expression of VEGF and IL-8 in sunitinib-treated cancer cells mainly through the beta-adrenoceptor-cAMP-PKA signaling pathway.	Norepinephrine	10-24	vascular endothelial growth factor A	Mus musculus	52-56
25448824-1	2015	5-HT2c G-protein coupled receptors located in the central nervous system bind the endogenous neurotransmitters serotonin and couple to G protein to mediate excitatory neurotransmission, which inhibits dopamine and norepinephrine release in the brain.	Norepinephrine	214-228	5-hydroxytryptamine receptor 2C	Rattus norvegicus	0-6
25569089-3	2015	Blockade of 5-HT2c receptors causes release of both noradrenaline and dopamine at the fronto-cortical dopaminergic and noradrenergic pathways.	Norepinephrine	52-65	5-hydroxytryptamine receptor 2C	Homo sapiens	12-18
24647754-7	2015	Monoamine quantification and gene expression profiling demonstrated a specific enrichment of noradrenaline only in the superficial layers of the superior colliculus of Isl2-EphA3 knock-in mice, where the retinotopy is duplicated, whereas transcript levels of receptors, transporters and metabolic enzymes of the monoaminergic pathway were not affected.	Norepinephrine	93-106	insulin related protein 2 (islet 2)	Mus musculus	168-172
26630956-4	2015	Several FAAH or MAGL inhibitors are reported to have no cannabimimetic side effects and, therefore, are new potential therapeutic options for patients with MDD who are resistant to first-line antidepressants (selective serotonin and serotonin-norepinephrine reuptake inhibitors).	Norepinephrine	243-257	monoglyceride lipase	Homo sapiens	16-20
25433327-2	2015	Peptidomic analysis of host-defense peptides in norepinephrine-stimulated skin secretions from frogs from the Cape Peninsula range resulted in the identification of two magainins, two peptide glycine-leucine-amide (PGLa) peptides, two xenopsin-precursor fragment (XPF) peptides, nine caerulein-precursor fragment (CPF) peptides, and a peptide related to peptide glycine-glutamine (PGQ) previously found in an extract of Xenopus laevis stomach.	Norepinephrine	48-62	prepro-PGLa S homeolog	Xenopus laevis	215-219
25002345-3	2014	It is observed that the combined infusion supplemented with norepinephrine brought about a lower mean pulmonary artery pressure; lower high-mobility group box 1 levels, pulmonary levels of interleukin-6, and arterial total nitrate/nitrite; lower apoptotic cells scores and total histological scores; but higher pulmonary gas exchange when compared with the separate infusion group and norepinephrine group.	Norepinephrine	60-74	high mobility group box 1	Rattus norvegicus	135-160
25128931-0	2014	Norepinephrine infusion with and without alpha-adrenergic blockade by phentolamine increases salivary alpha amylase in healthy men.	Norepinephrine	0-14	amylase alpha 1A	Homo sapiens	93-115
25128931-2	2014	While stress-induced sAA increases correlate with norepinephrine (NE) secretion, a potential mediating role of noradrenergic mechanisms remains unclear.	Norepinephrine	50-64	amylase alpha 1A	Homo sapiens	21-24
25179535-7	2014	Inhibitors of beta2-adrenergic receptor (beta2-AR), protein kinase A (PKA), and mTOR could reverse norepinephrine-induced Jagged 1 upregulation, indicating that the beta2-AR-PKA-mTOR pathway participates in this process.	Norepinephrine	99-113	adrenoceptor beta 2	Homo sapiens	14-39
25179535-7	2014	Inhibitors of beta2-adrenergic receptor (beta2-AR), protein kinase A (PKA), and mTOR could reverse norepinephrine-induced Jagged 1 upregulation, indicating that the beta2-AR-PKA-mTOR pathway participates in this process.	Norepinephrine	99-113	adrenoceptor beta 2	Homo sapiens	41-49
25179535-7	2014	Inhibitors of beta2-adrenergic receptor (beta2-AR), protein kinase A (PKA), and mTOR could reverse norepinephrine-induced Jagged 1 upregulation, indicating that the beta2-AR-PKA-mTOR pathway participates in this process.	Norepinephrine	99-113	adrenoceptor beta 2	Homo sapiens	165-173
25179535-9	2014	These data demonstrate that tumor angiogenesis mediated by the Jagged 1/Notch intercellular signaling is governed by the norepinephrine-activated beta2-AR-PKA-mTOR pathway.	Norepinephrine	121-135	adrenoceptor beta 2	Homo sapiens	146-154
25229819-8	2014	However, conditioned media from astrocytes exposed to norepinephrine or isoproterenol (a beta adrenergic agonist) significantly increased neurite outgrowth when applied to neuronal cultures.	Norepinephrine	54-68	amyloid beta precursor protein	Rattus norvegicus	87-93
24995933-12	2014	Chronic infusion of apelin-13 into the PVN in normotensive rats induced hypertension, increased plasma noradrenaline and AVP levels and promoted myocardial atrial natriuretic peptide and beta-myosin heavy chain mRNA expressions, two indicative markers of cardiac hypertrophy.	Norepinephrine	103-116	apelin	Rattus norvegicus	20-26
25050919-7	2014	Importantly, pro-hypertrophic signalling pathways such as those driven by angiotensin II and norepinephrine also regulate miR-23a-miR-27a-miR-24-2 cluster proximal promoter activity.	Norepinephrine	93-107	microRNA 23a	Homo sapiens	122-129
24614156-9	2014	Norepinephrine impaired keratinocyte migration; this effect was abrogated with B2AR-selective antagonist ICI-118,551 but not with B1AR-selective antagonist bisoprolol.	Norepinephrine	0-14	adrenoceptor beta 2	Homo sapiens	79-83
24614156-10	2014	Finally, for clinical relevance, we determined that norepinephrine was present in freshly wounded skin, thus providing a potential mechanism for impaired healing by local B2AR activation in wound-edge keratinocytes.	Norepinephrine	52-66	adrenoceptor beta 2	Homo sapiens	171-175
24614156-12	2014	Norepinephrine appears to be a stress-related mediator that impairs keratinocyte migration through activation of the B2AR.	Norepinephrine	0-14	adrenoceptor beta 2	Homo sapiens	117-121
25006259-7	2014	A crystal structure of the beta2-adrenoreceptor in complex with a covalent noradrenaline analog and a conformationally selective antibody (nanobody) verified that these agonists can be used to facilitate crystallogenesis.	Norepinephrine	75-88	adrenoceptor beta 2	Homo sapiens	27-47
24837703-11	2014	Consistently, in the presence of propranolol (10(-6)M), a beta-AR blocker, the arterenol (10(-8)M) effects on thymocytes were augmented.	Norepinephrine	79-88	adrenoceptor beta 2	Homo sapiens	63-65
24777478-5	2014	We demonstrate that norepinephrine acts through alpha1-adrenergic receptors to increase cytoplasmic Ca(2+), activating calcineurin and promoting migration of the fission protein Drp1 (encoded by Dnml1) to mitochondria.	Norepinephrine	20-34	dynamin 1-like	Rattus norvegicus	178-182
24777478-5	2014	We demonstrate that norepinephrine acts through alpha1-adrenergic receptors to increase cytoplasmic Ca(2+), activating calcineurin and promoting migration of the fission protein Drp1 (encoded by Dnml1) to mitochondria.	Norepinephrine	20-34	dynamin 1-like	Rattus norvegicus	195-200
24777478-6	2014	Dominant-negative Drp1 (K38A) not only prevented mitochondrial fission, it also blocked hypertrophic growth of cardiomyocytes in response to norepinephrine.	Norepinephrine	141-155	dynamin 1-like	Rattus norvegicus	18-22
24629015-6	2014	Ninety days after MI both WT and beta2 KO mice presented to cardiac dysfunction and remodelling accompanied by significantly increased norepinephrine and epinephrine plasma levels, exercise intolerance, changes towards more glycolytic fibres and vascular rarefaction in plantaris muscle.	Norepinephrine	135-149	hemoglobin, beta adult minor chain	Mus musculus	33-38
24796498-4	2014	Vasodilation induced by G-1 (selective GPER-agonist, 3 muM) from HRAs pre-contracted with norepinephrine amounted to 40+-5% in PMW, significantly larger than those obtained from M (20+-5%) or PGW (20+-5%).	Norepinephrine	90-104	G protein-coupled estrogen receptor 1	Homo sapiens	39-43
24440144-0	2014	The sympathetic nervous system modulates CD4(+)Foxp3(+) regulatory T cells via noradrenaline-dependent apoptosis in a murine model of lymphoproliferative disease.	Norepinephrine	79-92	CD4 antigen	Mus musculus	41-44
24497580-5	2014	Analysis of germline VGF-knockout mouse adrenal medulla revealed decreased LDCV size in noradrenergic chromaffin cells, increased adrenal norepinephrine and epinephrine content and circulating plasma epinephrine, and decreased adrenal CgB.	Norepinephrine	138-152	VGF nerve growth factor inducible	Mus musculus	21-24
24748481-2	2014	To explore this possibility, we assessed the treatment effects of desipramine and citalopram, which inhibit the reuptake of norepinephrine and serotonin into the presynaptic terminals, respectively, on changes in levels of CART-IR before and after the test swim in mouse brain.	Norepinephrine	124-138	CART prepropeptide	Mus musculus	223-227
24706871-1	2014	Galanin is a stress-inducible neuropeptide and cotransmitter in serotonin and norepinephrine neurons with a possible role in stress-related disorders.	Norepinephrine	78-92	galanin and GMAP prepropeptide	Homo sapiens	0-7
24431221-3	2014	The sympathetic neurotransmitter Norepinephrine (NE) induced complete and rapid mitochondrial fragmentation in BA, characterized by Drp1 phosphorylation and Opa1 cleavage.	Norepinephrine	33-47	OPA1, mitochondrial dynamin like GTPase	Mus musculus	157-161
24362581-7	2014	Tumors arising in patients with mutations of the SDHB gene have at least a 30 % chance of metastasizing and typically produce norepinephrine and/or dopamine.	Norepinephrine	126-140	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	49-53
24231511-9	2014	Brain Ang (1-7) administration profoundly modified responses to stress, indicated by altered levels of several stress hormones, including Ang II, glucocorticoid, norepinephrine, serotonin, and dopamine, in blood or stress-related brain regions.	Norepinephrine	162-176	angiogenin	Rattus norvegicus	6-9
24877149-2	2014	In the rodent, Aanat gene expression displays a marked circadian rhythm; release of norepinephrine in the gland at night causes a cAMP-based induction of Aanat transcription.	Norepinephrine	84-98	aralkylamine N-acetyltransferase	Homo sapiens	154-159
24138638-2	2014	Activation of brain CB1 receptors inhibited the secretion of adrenal catecholamines (noradrenaline and adrenaline) induced by i.c.v.	Norepinephrine	85-98	cannabinoid receptor 1	Rattus norvegicus	20-23
24189139-0	2014	Role of calcium and EPAC in norepinephrine-induced ghrelin secretion.	Norepinephrine	28-42	Rap guanine nucleotide exchange factor 3	Homo sapiens	20-24
24025942-11	2014	The coordinate loss of dopamine and norepinephrine neurons in VMAT2 LO mice parallels the pattern of neurodegeneration that occurs in human PD, and demonstrates that insufficient catecholamine storage can cause spontaneous degeneration in susceptible neurons, underscoring cytosolic catecholamine catabolism as a determinant of neuronal susceptibility in PD.	Norepinephrine	36-50	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	62-67
24144187-3	2013	Herein, the interaction of Ngb with the quinones generated by oxidation of catecholamines (dopamine, norepinephrine) and catechol estrogens (2-hydroxyestradiol and 4-hydroxyestradiol), which have been implicated in neurodegenerative pathologies like Parkinson"s and Alzheimer"s diseases, has been investigated.	Norepinephrine	101-115	neuroglobin	Homo sapiens	27-30
24295263-7	2013	The contraction induced by norepinephrine was reversed by the drugs with the following rank order of efficacy: sodium nitroprusside &gt; delquamine &gt; sildenafil &gt; C-type natriuretic peptide &gt; forskolin &gt; acetylcholine.	Norepinephrine	27-41	natriuretic peptide C	Homo sapiens	169-195
23810893-10	2013	Importantly, PDE2-overexpressing cardiomyocytes showed marked protection from norepinephrine-induced hypertrophic responses.	Norepinephrine	78-92	phosphodiesterase 2A	Rattus norvegicus	13-17
23742775-16	2013	Norepinephrine significantly increased the activity of ROCK-1 in normal rats but not in cirrhotic ones.	Norepinephrine	0-14	Rho-associated coiled-coil containing protein kinase 1	Rattus norvegicus	55-61
23742775-17	2013	Norepinephrine significantly increased ROCK-1 activity in cirrhotic rats when GRK-2 inhibitor was used.	Norepinephrine	0-14	Rho-associated coiled-coil containing protein kinase 1	Rattus norvegicus	39-45
23609393-7	2013	After medication, increasing possession of a G allele at the MspI polymorphism of the ADRA2A gene was associated with increased MPH-related change in response time variability in the flanker task (P = 1.0 x 10).Our study suggested an association between norepinephrine gene variants and response time variability measured at baseline and after MPH treatment in children with ADHD.	Norepinephrine	254-268	adrenoceptor alpha 2A	Homo sapiens	86-92
23061915-7	2013	KEY RESULTS: In SaM-1 cells, bath-applied noradrenaline elevated intracellular Ca(2+)  concentration and this effect was abolished by both chloroethylclonidine, an alpha(1B) -adrenoceptor antagonist, and U73122, a PLC inhibitor.	Norepinephrine	42-55	adrenoceptor alpha 1B	Homo sapiens	164-187
23303344-10	2013	Treatment with norepinephrine bitartrate stimulated Vegf messenger RNA expression and protein secretion in ChECs and RPE cells.	Norepinephrine	15-29	vascular endothelial growth factor A	Mus musculus	52-56
23421681-4	2013	The 6-position of serotonin and the para-hydroxyl groups of dopamine and norepinephrine were found to face Ala173 in hSERT, Gly153 in hDAT, and Gly149 in hNET.	Norepinephrine	73-87	solute carrier family 6 member 3	Homo sapiens	134-138
23421681-7	2013	Uptake experiments support that the 5-hydroxyl group of serotonin and the meta-hydroxyl group norepinephrine and dopamine are placed in the hydrophilic pocket around Ala173, Ser438, and Thr439 in hSERT corresponding to Gly149, Ser419, Ser420 in hNET and Gly153 Ser422 and Ala423 in hDAT.	Norepinephrine	94-108	solute carrier family 6 member 3	Homo sapiens	282-286
22508464-0	2013	Increased vulnerability of the brain norepinephrine system of females to corticotropin-releasing factor overexpression.	Norepinephrine	37-51	corticotropin releasing hormone	Mus musculus	73-103
23011268-3	2013	First, we found reduced levels of dopamine, serotonin and norepinephrine in the nucleus accumbens (NAC) of DISC1-Q31L mutants.	Norepinephrine	58-72	disrupted in schizophrenia 1	Mus musculus	107-112
23469282-8	2013	HDAC10 expression was found in AgRP neurons, POMC neurons, dopamine neurons and noradrenaline neurons but not in other neuronal groups.	Norepinephrine	80-93	histone deacetylase 10	Homo sapiens	0-6
23105094-8	2012	Interestingly, the Ser-364 allele (detected in ~15% subjects) was strongly associated with profound reduction (up to ~2.1-fold) in plasma norepinephrine/epinephrine levels consistent with the diminished nAChR desensitization-blocking effect of CST-Ser-364 as compared with CST-WT.	Norepinephrine	138-152	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	203-208
22923471-7	2012	Moreover, L-PGDS knockout mice exhibited increased expression of genes involved in thermogenesis and increased norepinephrine-stimulated glucose uptake to BAT, suggesting that sympathetically mediated changes in glucose uptake may have improved glucose tolerance.	Norepinephrine	111-125	prostaglandin D2 synthase (brain)	Mus musculus	10-16
23190744-10	2012	Patients with elevated cTnI more frequently required vasopressors-norepinephrine (73% vs 50%, P = 0.008).	Norepinephrine	66-80	troponin I3, cardiac type	Homo sapiens	23-27
22996798-2	2012	CE with LIF detection for the determination of FITC derivatized catecholamines (dopamine, epinephrine, and norepinephrine) was demonstrated.	Norepinephrine	107-121	LIF, interleukin 6 family cytokine	Rattus norvegicus	8-11
22722024-0	2012	Presynaptic alpha2-adrenoceptors control the inhibitory action of presynaptic CB1 cannabinoid receptors on prefrontocortical norepinephrine release in the rat.	Norepinephrine	125-139	cannabinoid receptor 1	Rattus norvegicus	78-81
22752240-1	2012	Norepinephrine transporter (NET) regulates noradrenergic synaptic transmission by controlling extracellular levels of norepinephrine (NE).	Norepinephrine	118-132	solute carrier family 6 member 2	Bos taurus	0-26
22513004-6	2012	Functional studies, conducted primarily on lipocalin 2 (Lcn2), the mouse homologue of human NGAL have revealed that Lcn2 has a strong affinity for iron complexed to both bacterial siderophores (iron-binding proteins) and certain human proteins like norepinephrine.	Norepinephrine	249-263	lipocalin 2	Homo sapiens	92-96
22513004-6	2012	Functional studies, conducted primarily on lipocalin 2 (Lcn2), the mouse homologue of human NGAL have revealed that Lcn2 has a strong affinity for iron complexed to both bacterial siderophores (iron-binding proteins) and certain human proteins like norepinephrine.	Norepinephrine	249-263	lipocalin 2	Homo sapiens	116-120
23487485-1	2012	Our previous study showed a significant relationships between static exercise-induced changes in plasma adrenomedullin (ADM) and those in endothelin-1 (ET-1), noradrenaline (NA) and pre-ejection period/left ventricular ejection time ratio (PEP/LVET) in older healthy men.	Norepinephrine	159-172	adrenomedullin	Homo sapiens	104-118
22372951-2	2012	Cytokines that act through gp130, such as ciliary neurotrophic factor (CNTF) decrease norepinephrine production in sympathetic neurons by suppressing TH mRNA and stimulating degradation of TH protein, leading to the loss of enzyme.	Norepinephrine	86-100	Neutrophil migration (granulocyte glycoprotein)	Homo sapiens	27-32
22372951-2	2012	Cytokines that act through gp130, such as ciliary neurotrophic factor (CNTF) decrease norepinephrine production in sympathetic neurons by suppressing TH mRNA and stimulating degradation of TH protein, leading to the loss of enzyme.	Norepinephrine	86-100	ciliary neurotrophic factor	Homo sapiens	42-69
22372951-2	2012	Cytokines that act through gp130, such as ciliary neurotrophic factor (CNTF) decrease norepinephrine production in sympathetic neurons by suppressing TH mRNA and stimulating degradation of TH protein, leading to the loss of enzyme.	Norepinephrine	86-100	ciliary neurotrophic factor	Homo sapiens	71-75
22318196-8	2012	In cultured hippocampal neurons, application of serotonin or norepinephrine (10-50 muM) induced increase in synaptic transmission and targeting of BDNF mRNA in dendrites.	Norepinephrine	61-75	brain derived neurotrophic factor	Homo sapiens	147-151
22538810-1	2012	Parathyroid hormone (PTH), the major calcium-regulating hormone, and norepinephrine (NE), the principal neurotransmitter of sympathetic nerves, regulate bone remodeling by activating distinct cell-surface G protein-coupled receptors in osteoblasts: the parathyroid hormone type 1 receptor (PTHR) and the beta(2)-adrenergic receptor (beta(2)AR), respectively.	Norepinephrine	69-83	parathyroid hormone 1 receptor	Mus musculus	290-294
22371491-3	2012	By utilizing the G protein-coupled receptor (GPCR) heteromer identification technology on the live cell-based bioluminescence resonance energy transfer (BRET) assay platform, our studies in human embryonic kidney 293 cells have identified norepinephrine-dependent beta-arrestin recruitment that was in turn dependent upon co-expression of alpha(1A)AR with CXCR2.	Norepinephrine	239-253	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	339-347
23429762-1	2012	OBJECTIVE: This study examined the association between the brain-derived neurotrophic factor (BDNF) (Val66Met) polymorphism and the response to the addition of an atypical antipsychotic drug to a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) in treatment-refractory depression.	Norepinephrine	255-269	brain derived neurotrophic factor	Homo sapiens	59-92
23429762-1	2012	OBJECTIVE: This study examined the association between the brain-derived neurotrophic factor (BDNF) (Val66Met) polymorphism and the response to the addition of an atypical antipsychotic drug to a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) in treatment-refractory depression.	Norepinephrine	255-269	brain derived neurotrophic factor	Homo sapiens	94-98
22253419-6	2012	In brown adipocytes in culture, norepinephrine, cAMP, and activators of PPARgamma and PPARalpha induced RBP4 gene expression and RBP4 protein release.	Norepinephrine	32-46	retinol binding protein 4, plasma	Mus musculus	104-108
22253419-6	2012	In brown adipocytes in culture, norepinephrine, cAMP, and activators of PPARgamma and PPARalpha induced RBP4 gene expression and RBP4 protein release.	Norepinephrine	32-46	retinol binding protein 4, plasma	Mus musculus	129-133
22253419-7	2012	The induction of RBP4 gene expression by norepinephrine required intact PPAR-dependent pathways, as evidenced by impaired response of the RBP4 gene expression to norepinephrine in PPARalpha-null brown adipocytes or in the presence of inhibitors of PPARgamma and PPARalpha.	Norepinephrine	41-55	retinol binding protein 4, plasma	Mus musculus	17-21
22253419-7	2012	The induction of RBP4 gene expression by norepinephrine required intact PPAR-dependent pathways, as evidenced by impaired response of the RBP4 gene expression to norepinephrine in PPARalpha-null brown adipocytes or in the presence of inhibitors of PPARgamma and PPARalpha.	Norepinephrine	41-55	retinol binding protein 4, plasma	Mus musculus	138-142
22253419-7	2012	The induction of RBP4 gene expression by norepinephrine required intact PPAR-dependent pathways, as evidenced by impaired response of the RBP4 gene expression to norepinephrine in PPARalpha-null brown adipocytes or in the presence of inhibitors of PPARgamma and PPARalpha.	Norepinephrine	162-176	retinol binding protein 4, plasma	Mus musculus	17-21
22253419-8	2012	PPARgamma and norepinephrine can also induce the RBP4 gene in white adipocytes, and overexpression of PPARalpha confers regulation by this PPAR subtype to white adipocytes.	Norepinephrine	14-28	retinol binding protein 4, plasma	Mus musculus	49-53
22253419-11	2012	The induction of the RBP4 gene expression by norepinephrine in brown adipocytes is protein synthesis dependent and requires PPARgamma-coactivator-1-alpha, which acts as a norepinephine-induced coactivator of PPAR on the RBP4 gene.	Norepinephrine	45-59	retinol binding protein 4, plasma	Mus musculus	21-25
22253419-11	2012	The induction of the RBP4 gene expression by norepinephrine in brown adipocytes is protein synthesis dependent and requires PPARgamma-coactivator-1-alpha, which acts as a norepinephine-induced coactivator of PPAR on the RBP4 gene.	Norepinephrine	45-59	retinol binding protein 4, plasma	Mus musculus	220-224
22127496-0	2012	Norepinephrine promotes the beta1-integrin-mediated adhesion of MDA-MB-231 cells to vascular endothelium by the induction of a GROalpha release.	Norepinephrine	0-14	integrin subunit beta 1	Homo sapiens	28-42
22127496-0	2012	Norepinephrine promotes the beta1-integrin-mediated adhesion of MDA-MB-231 cells to vascular endothelium by the induction of a GROalpha release.	Norepinephrine	0-14	C-X-C motif chemokine ligand 1	Homo sapiens	127-135
22127496-4	2012	The adhesion of MDA-MB-231 cells was based on a norepinephrine-mediated release of GROalpha from HMVECs.	Norepinephrine	48-62	C-X-C motif chemokine ligand 1	Homo sapiens	83-91
22219298-7	2012	Noradrenaline and dopamine enhanced LTP induction in STX1A(-/-) mice, whereas catecholamine depletion reduced LTP induction in wild-type mice.	Norepinephrine	0-13	syntaxin 1A (brain)	Mus musculus	53-58
23226423-8	2012	Noradrenaline- (NA-) and phenylephrine- (PE-) induced phosphorylation of Elk1 was assessed by Western blot analysis using a phospho-specific antibody.	Norepinephrine	0-13	ETS transcription factor ELK1	Homo sapiens	73-77
23226423-16	2012	CONCLUSIONS: Silodosin blocks the activation of the two transcription factors, Elk1 and SRF, which is induced by noradrenaline in the human prostate.	Norepinephrine	113-126	ETS transcription factor ELK1	Homo sapiens	79-83
23226423-16	2012	CONCLUSIONS: Silodosin blocks the activation of the two transcription factors, Elk1 and SRF, which is induced by noradrenaline in the human prostate.	Norepinephrine	113-126	serum response factor	Homo sapiens	88-91
21536121-4	2011	In the present study, we examined the effects of noradrenaline and adrenaline, stress-related catecholamines, on IL-33 production by dendritic cells (DCs).	Norepinephrine	49-62	interleukin 33	Mus musculus	113-118
21536121-7	2011	Noradrenaline or adrenaline dramatically enhanced IL-33 mRNA expression and its protein synthesis by DCs upon LPS stimulation.	Norepinephrine	0-13	interleukin 33	Mus musculus	50-55
21536121-8	2011	The noradrenaline-induced enhancement of IL-33 production was completely blocked by beta(2)-adrenoceptor specific antagonist ICI 118,551, while beta(2)-adrenoceptor specific agonist salmeterol enhanced DC production of IL-33.	Norepinephrine	4-17	interleukin 33	Mus musculus	41-46
21536121-8	2011	The noradrenaline-induced enhancement of IL-33 production was completely blocked by beta(2)-adrenoceptor specific antagonist ICI 118,551, while beta(2)-adrenoceptor specific agonist salmeterol enhanced DC production of IL-33.	Norepinephrine	4-17	interleukin 33	Mus musculus	219-224
21536121-9	2011	Protein kinase A (PKA) specific inhibitor H89 blocked the noradrenaline-induced IL-33 production.	Norepinephrine	58-71	interleukin 33	Mus musculus	80-85
21683614-10	2011	In addition, intradermal injection of norepinephrine along with Pam3CysSK4+muramyl dipeptide increased the Th17 response to an immunogenic protein and this effect was reversed by a beta2-adrenoceptor antagonist.	Norepinephrine	38-52	hemoglobin, beta adult minor chain	Mus musculus	181-186
21738056-8	2011	Furthermore, the inhibition of ErbB2 expression in the RVLM by RNA interference significantly increased arterial pressure, HR, and urinary norepinephrine excretion in conscious WKY rats (P &lt; 0.01).	Norepinephrine	139-153	erb-b2 receptor tyrosine kinase 2	Rattus norvegicus	31-36
21936631-6	2011	CONCLUSIONS: Norepinephrine increases ubiquitination of Cx43 in cardiomyocytes, possibly via Nedd4.	Norepinephrine	13-27	NEDD4 E3 ubiquitin protein ligase	Rattus norvegicus	93-98
21560326-3	2011	The effects of accumulated apelin on pulmonary arterial rings preconstricted with norepinephrine (NE) were observed by using tissue organ bath system.	Norepinephrine	82-96	apelin	Rattus norvegicus	27-33
21035322-1	2011	Rapid oxidation of dopamine (DA) or L-noradrenaline (NA) by K(3)Fe(CN)(6) yields poly(DA) (PDA(C)) or poly(NA) (PNA(C)) with glucose oxidase (GOx) effectively entrapped, and such an enzyme-entrapped catecholamine polymer is cast on an Au electrode followed by chitosan (CS) strengthening for biosensing and fabrication of a biofuel cell (BFC).	Norepinephrine	36-51	hydroxyacid oxidase 1	Homo sapiens	125-140
21035322-1	2011	Rapid oxidation of dopamine (DA) or L-noradrenaline (NA) by K(3)Fe(CN)(6) yields poly(DA) (PDA(C)) or poly(NA) (PNA(C)) with glucose oxidase (GOx) effectively entrapped, and such an enzyme-entrapped catecholamine polymer is cast on an Au electrode followed by chitosan (CS) strengthening for biosensing and fabrication of a biofuel cell (BFC).	Norepinephrine	36-51	hydroxyacid oxidase 1	Homo sapiens	142-145
21233615-5	2011	RESULTS: The reactivity of SMAs and VSMCs to norepinephrine after shock or hypoxia was positively correlated with changes in the RhoA and Rac1 activity ratio.	Norepinephrine	45-59	ras homolog family member A	Rattus norvegicus	129-133
22076148-6	2011	In vivo, chronic treatment with the non-selective antidepressant imipramine as well as the norepinephrine-selective reuptake inhibitor desipramine or the serotonin-selective reuptake inhibitor fluoxetine all decrease p21 expression, and this was associated with increased neurogenesis.	Norepinephrine	91-105	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	217-220
20926777-0	2010	Identification and functional implication of a Rho kinase-dependent moesin-EBP50 interaction in noradrenaline-stimulated artery.	Norepinephrine	96-109	moesin	Rattus norvegicus	68-74
20858707-6	2010	In contrast, hOCT3 is less selective than hPMAT toward the monoamines, and the V(max)/K(m) rank order for hOCT3 is: histamine &gt; norepinephrine, epinephrine &gt; dopamine &gt;5-HT.	Norepinephrine	131-145	solute carrier family 22 member 3	Homo sapiens	13-18
20858707-6	2010	In contrast, hOCT3 is less selective than hPMAT toward the monoamines, and the V(max)/K(m) rank order for hOCT3 is: histamine &gt; norepinephrine, epinephrine &gt; dopamine &gt;5-HT.	Norepinephrine	131-145	solute carrier family 22 member 3	Homo sapiens	106-111
20858707-9	2010	Our results suggest that hOCT3 represents a major uptake(2) transporter for histamine, epinephrine, and norepinephrine.	Norepinephrine	104-118	solute carrier family 22 member 3	Homo sapiens	25-30
20680617-1	2010	In this study, the first micro-total analysis system (mu-TAS) for catecholamines (dopamine, epinephrine, and norepinephrine) analysis in which preconcentration, separation, and determination steps were integrated on a microchip was developed.	Norepinephrine	109-123	THAS	Homo sapiens	57-60
20599923-8	2010	Norepinephrine responses in veins from alpha(2C)-adrenoceptor knock-out (KO) mice were not different from wild type veins.	Norepinephrine	0-14	adrenergic receptor, alpha 2c	Mus musculus	39-47
20599923-9	2010	Yohimbine inhibited norepinephrine constrictions in alpha(2C)-adrenoceptor KO veins suggesting that there is upregulation of other alpha(2)-adrenoceptors in alpha(2C)-KO mice.	Norepinephrine	20-34	adrenergic receptor, alpha 2c	Mus musculus	52-60
20361987-0	2010	Noradrenaline acting at beta-adrenoceptors induces expression of IL-1beta and its negative regulators IL-1ra and IL-1RII, and drives an overall anti-inflammatory phenotype in rat cortex.	Norepinephrine	0-13	interleukin 1 receptor antagonist	Rattus norvegicus	102-108
20464574-3	2010	This hypothesis derived from the results of the biochemical studies, mainly generated from our laboratory, on the possible metabolic shifts of tyrosine toward an activation of decarboxylase enzyme activity with an increased synthesis of traces amines, i.e. tyr, oct and syn, and an unphysiological synthesis of noradrenalin and dopamine.	Norepinephrine	311-323	synemin	Homo sapiens	224-227
20147605-6	2010	The stimulation of chloride transport by norepinephrine was mediated entirely by its beta-adrenergic effect; however, both the beta- and alpha-adrenergic agonists isoproterenol and phenylephrine prevent the ANG II-mediated inhibition in chloride transport.	Norepinephrine	41-55	angiogenin	Rattus norvegicus	207-210
20086155-0	2010	Neutrophil gelatinase-associated lipocalin expresses antimicrobial activity by interfering with L-norepinephrine-mediated bacterial iron acquisition.	Norepinephrine	96-112	lipocalin 2	Homo sapiens	0-42
21299064-5	2010	These effects of GAL in promoting overconsumption may involve various neurotransmitters, with GAL facilitating intake by stimulating norepinephrine and dopamine and reducing satiety by decreasing serotonin and acetylcholine.	Norepinephrine	133-147	galanin and GMAP prepropeptide	Homo sapiens	94-97
19968887-6	2009	In contrast, activated CD8+ T lymphocytes showed a reduced migratory activity in the presence of norepinephrine and substance P.	Norepinephrine	97-111	CD8a molecule	Homo sapiens	23-26
19968887-7	2009	With regard to extravasation we found norepinephrine to induce adhesion of activated CD8+ T cells: norepinephrine increased the interleukin-8 release from endothelium, which in turn had effect on the activated CXCR1+ CD8+ T cells.	Norepinephrine	38-52	CD8a molecule	Homo sapiens	85-88
19968887-7	2009	With regard to extravasation we found norepinephrine to induce adhesion of activated CD8+ T cells: norepinephrine increased the interleukin-8 release from endothelium, which in turn had effect on the activated CXCR1+ CD8+ T cells.	Norepinephrine	38-52	C-X-C motif chemokine receptor 1	Homo sapiens	210-215
19968887-7	2009	With regard to extravasation we found norepinephrine to induce adhesion of activated CD8+ T cells: norepinephrine increased the interleukin-8 release from endothelium, which in turn had effect on the activated CXCR1+ CD8+ T cells.	Norepinephrine	38-52	CD8a molecule	Homo sapiens	217-220
19968887-7	2009	With regard to extravasation we found norepinephrine to induce adhesion of activated CD8+ T cells: norepinephrine increased the interleukin-8 release from endothelium, which in turn had effect on the activated CXCR1+ CD8+ T cells.	Norepinephrine	99-113	CD8a molecule	Homo sapiens	85-88
19968887-7	2009	With regard to extravasation we found norepinephrine to induce adhesion of activated CD8+ T cells: norepinephrine increased the interleukin-8 release from endothelium, which in turn had effect on the activated CXCR1+ CD8+ T cells.	Norepinephrine	99-113	C-X-C motif chemokine receptor 1	Homo sapiens	210-215
19968887-7	2009	With regard to extravasation we found norepinephrine to induce adhesion of activated CD8+ T cells: norepinephrine increased the interleukin-8 release from endothelium, which in turn had effect on the activated CXCR1+ CD8+ T cells.	Norepinephrine	99-113	CD8a molecule	Homo sapiens	217-220
19502771-8	2009	Moreover, norepinephrine levels were inversely correlated (r=-0.591; p&lt;0.001) with IFN-gamma expression, a typical Th1 cytokine.	Norepinephrine	10-24	negative elongation factor complex member C/D	Homo sapiens	118-121
19295473-0	2009	Central cannabinoid 1 receptor antagonist administration prevents endotoxic hypotension affecting norepinephrine release in the preoptic anterior hypothalamic area.	Norepinephrine	98-112	cannabinoid receptor 1	Rattus norvegicus	8-21
19502644-6	2009	Consistent with increased fatty acid utilization, brown adipocytes cultured from Pctp(-/-) mice exhibited higher oxygen consumption rates in response to norepinephrine.	Norepinephrine	153-167	phosphatidylcholine transfer protein	Mus musculus	81-85
19643099-4	2009	NOX-1 induced a relaxation of vascular smooth muscles in both endothelium intact and denuded rat aortic rings precontracted with norepinephrine or phenylephrine or KCl.	Norepinephrine	129-143	NADPH oxidase 1	Rattus norvegicus	0-5
19643099-5	2009	NOX-1 also significantly antagonized cumulative dose-response effect of norepinephrine, phenylephrine, KCl or calcium with reduction in submaximal contractions.	Norepinephrine	72-86	NADPH oxidase 1	Rattus norvegicus	0-5
19464349-3	2009	We hypothesized that the 5-HT and norepinephrine reuptake inhibitor, venlafaxine, would stimulate BDNF expression and alter LTP more effectively than the selective 5-HT reuptake inhibitor, citalopram.	Norepinephrine	34-48	brain-derived neurotrophic factor	Rattus norvegicus	98-102
19632110-2	2009	Synthesis of the two diastereomeric isomers of the molecule followed by chiral resolution of each enantiomer revealed the (2R,3S)-isomer to be a potent norepinephrine reuptake inhibitor (IC(50)=28 nM) with excellent selectivity over the dopamine transporter and 13-fold selectivity over the serotonin transporter.	Norepinephrine	152-166	solute carrier family 6 member 3	Homo sapiens	237-257
19573018-7	2009	Transfection of shRNAs specific to Phox2a or Phox2b genes significantly reduced mRNA and protein levels of NET and DBH after shutdown of endogenous Phox2, which was accompanied by a decreased [(3)H]norepinephrine uptake.	Norepinephrine	198-212	paired like homeobox 2B	Homo sapiens	45-51
19576631-0	2009	Brain derived neurotrophic factor and neurotrophin-4 employ different intracellular pathways to modulate norepinephrine uptake and release in rat hypothalamus.	Norepinephrine	105-119	brain-derived neurotrophic factor	Rattus norvegicus	0-33
19576631-0	2009	Brain derived neurotrophic factor and neurotrophin-4 employ different intracellular pathways to modulate norepinephrine uptake and release in rat hypothalamus.	Norepinephrine	105-119	neurotrophin 4	Rattus norvegicus	38-52
19576631-4	2009	Thus, we have studied the effects of the neurotrophin family members nerve growth factor (NGF), brain derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4) on norepinephrine (NE) neuronal uptake and its evoked release, as well as the receptor and the intracellular pathways involved in these processes in rat hypothalamus.	Norepinephrine	166-180	neurotrophin 4	Rattus norvegicus	141-155
19576631-4	2009	Thus, we have studied the effects of the neurotrophin family members nerve growth factor (NGF), brain derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4) on norepinephrine (NE) neuronal uptake and its evoked release, as well as the receptor and the intracellular pathways involved in these processes in rat hypothalamus.	Norepinephrine	166-180	neurotrophin 4	Rattus norvegicus	157-161
19553450-5	2009	We hypothesized that since these animals exhibit deficits in other monoamine systems (norepinephrine and serotonin), which are known to regulate some of these behaviors, the VMAT2-deficient mice may display some of the nonmotor symptoms associated with PD.	Norepinephrine	86-100	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	174-179
19393628-4	2009	In endothelium-intact rat aorta, pretreatment with visfatin (100 ng/ml, 30 min) inhibited noradrenaline (NA; 1 nM-1 microM)-induced contraction.	Norepinephrine	90-103	nicotinamide phosphoribosyltransferase	Rattus norvegicus	51-59
19152834-10	2009	They further suggest that the inhibitory effect of noradrenaline on PS may be due to the A1/C1, A2 and to a lesser degree to A5 neurons but not from those of the LC as previously hypothesized.	Norepinephrine	51-64	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	89-98
19073902-3	2009	We hypothesized that in this setting, renin secretion and renin-dependent sodium excretion are controlled by via the renal nerves and therefore are eliminated or reduced by blocking the action of norepinephrine on the juxtaglomerular cells with the beta1-receptor antagonist metoprolol.	Norepinephrine	196-210	renin	Canis lupus familiaris	38-43
19073902-3	2009	We hypothesized that in this setting, renin secretion and renin-dependent sodium excretion are controlled by via the renal nerves and therefore are eliminated or reduced by blocking the action of norepinephrine on the juxtaglomerular cells with the beta1-receptor antagonist metoprolol.	Norepinephrine	196-210	renin	Canis lupus familiaris	58-63
19073902-12	2009	In conclusion, PRC depended on dietary sodium and beta1-adrenergic control as expected; however, the acute sodium-driven decrease in PRC at constant MAP and GFR was unaffected by beta1-receptor blockade demonstrating that renin may be regulated without changes in MAP, GFR, or beta1-mediated effects of norepinephrine.	Norepinephrine	303-317	renin	Canis lupus familiaris	222-227
18854975-7	2009	Due to the noradrenaline infusion heart rate, end-systolic pressure as well as dp/dt (max) and dp/dt (max) were significantly higher and relaxation time significantly lower in the CLP-mice, again without difference between the genetic strains.	Norepinephrine	11-24	hyaluronan and proteoglycan link protein 1	Mus musculus	180-183
19077688-7	2009	Similarly, renal vascular reactivity to angiotensin II, endothelin-1 and norepinephrine is attenuated by approximately 50% in mice lacking CD38, the main mammalian ADPR cyclase.	Norepinephrine	73-87	CD38 antigen	Mus musculus	139-143
19092146-7	2009	As compared with control subjects, MC4R-deficient subjects had a lower increase in heart rate on waking (P=0.007), a lower heart rate during euglycemic hyperinsulinemia (P&lt;0.001), and lower 24-hour urinary norepinephrine excretion (P=0.04).	Norepinephrine	209-223	melanocortin 4 receptor	Homo sapiens	35-39
19262750-2	2009	We have previously shown that OAMB, a Drosophila G-protein-coupled receptor for octopamine (the insect counterpart of mammalian norepinephrine), is required for ovulation induced upon mating.	Norepinephrine	128-142	Octopamine receptor in mushroom bodies	Drosophila melanogaster	30-34
19120138-3	2008	Forced swimming, systemic interleukin-1beta (IL-1beta), and cholecystokinin (CCK) all activate brain stem noradrenergic cell groups, stimulate noradrenaline release in the PVN, and activate the HPA axis in nonpregnant rats.	Norepinephrine	143-156	cholecystokinin	Rattus norvegicus	60-75
19120138-3	2008	Forced swimming, systemic interleukin-1beta (IL-1beta), and cholecystokinin (CCK) all activate brain stem noradrenergic cell groups, stimulate noradrenaline release in the PVN, and activate the HPA axis in nonpregnant rats.	Norepinephrine	143-156	cholecystokinin	Rattus norvegicus	77-80
18772317-1	2008	Fluorescence studies with purified human beta(2)-adrenoceptor (beta(2)AR) revealed that the endogenous catecholamines, (-)-epinephrine (EPI), (-)-norepinephrine (NE), and dopamine (DOP), stabilize distinct active receptor conformations.	Norepinephrine	142-160	adrenoceptor beta 2	Homo sapiens	41-61
18772317-1	2008	Fluorescence studies with purified human beta(2)-adrenoceptor (beta(2)AR) revealed that the endogenous catecholamines, (-)-epinephrine (EPI), (-)-norepinephrine (NE), and dopamine (DOP), stabilize distinct active receptor conformations.	Norepinephrine	142-160	adrenoceptor beta 2	Homo sapiens	63-72
19020050-5	2008	Conversely, the transfection of synthetic anti-miR oligonucleotides that inhibit miR-338 increases COXIV levels, and results in a significant increase in oxidative phosphorylation and also norepinephrine uptake in the axons.	Norepinephrine	189-203	membrane associated ring-CH-type finger 8	Homo sapiens	47-50
18980978-11	2008	In vitro analyses showed that macrophage MMP-9 production could be directly enhanced (up to a 2-fold increase) by the stress hormones norepinephrine and cortisol.	Norepinephrine	134-148	matrix metallopeptidase 9	Homo sapiens	41-46
18594791-10	2008	Urinary epinephrine and norepinephrine excretion in Il1ra (-/-) mice was significantly increased compared with WT mice, suggesting that Il1ra (-/-) mice have increased sympathetic tone.	Norepinephrine	24-38	interleukin 1 receptor antagonist	Mus musculus	52-57
18644202-2	2008	Noradrenaline-induced relaxations of the muscularis mucosae in each region were unaffected by atenolol, butoxamine or propranolol, but they were attenuated by the selective beta3-adrenoceptor antagonist cyanopindolol.	Norepinephrine	0-13	adrenoceptor beta 3	Rattus norvegicus	173-191
18644202-8	2008	Distal colonic muscularis mucosae lacked excitatory adrenoceptors and only responded to noradrenaline with beta3-adrenoceptor-mediated relaxations.	Norepinephrine	88-101	adrenoceptor beta 3	Rattus norvegicus	107-125
18598300-0	2008	Geniposide enhances melanogenesis by stem cell factor/c-Kit signalling in norepinephrine-exposed normal human epidermal melanocyte.	Norepinephrine	74-88	KIT ligand	Homo sapiens	37-53
18598300-2	2008	Stem cell factor from keratinocyte recognizes and activates its receptor c-kit carried by melanocyte to potent enhance melanocytic melanogenesis that can be suppressed by norepinephrine.	Norepinephrine	171-185	KIT ligand	Homo sapiens	0-16
18598300-8	2008	In addition, spectrophotometry demonstrated the enhancement effect of geniposide on melanogenesis (tyrosinase activity and melanin production) in norepinephrine-exposed normal human epidermal melanocyte at the presence of stem cell factor, which was blocked by c-kit inhibitory antibody K44.2.	Norepinephrine	146-160	KIT ligand	Homo sapiens	222-238
18598300-9	2008	Data from this study suggest that geniposide can enhance melanogenesis by stem cell factor/c-kit signalling in which the expression of c-kit receptor is augmented in norepinephrine-exposed normal human epidermal melanocyte.	Norepinephrine	166-180	KIT ligand	Homo sapiens	74-90
18424435-3	2008	Indeed, AP-2beta null mice expressed significantly reduced levels of both noradrenaline (NA) and NA-synthesizing dopamine beta-hydroxylase in the peripheral nervous system.	Norepinephrine	74-87	transcription factor AP-2 beta	Mus musculus	8-16
18423439-4	2008	In addition, the corticotropin-releasing factor-induced elevation of noradrenaline release in the hypothalamic paraventricular nucleus and plasma corticosterone were abolished by hexamethonium, a non-selective nicotinic acetylcholine receptor antagonist, at 1.8 micromol/animal, intracerebroventricularly, and alpha-conotoxin MII, a potent alpha(3)beta(2) nicotinic acetylcholine receptor antagonist, at 30 nmol/animal, i.c.v.	Norepinephrine	69-82	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	210-242
18423439-4	2008	In addition, the corticotropin-releasing factor-induced elevation of noradrenaline release in the hypothalamic paraventricular nucleus and plasma corticosterone were abolished by hexamethonium, a non-selective nicotinic acetylcholine receptor antagonist, at 1.8 micromol/animal, intracerebroventricularly, and alpha-conotoxin MII, a potent alpha(3)beta(2) nicotinic acetylcholine receptor antagonist, at 30 nmol/animal, i.c.v.	Norepinephrine	69-82	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	356-388
18172756-0	2008	BDNF level in the rat prefrontal cortex increases following chronic but not acute treatment with duloxetine, a dual acting inhibitor of noradrenaline and serotonin re-uptake.	Norepinephrine	136-149	brain-derived neurotrophic factor	Rattus norvegicus	0-4
18172756-2	2008	The brain level of BDNF is changed by several mood stabilizers and antidepressant drugs acting on neurotransmitters such as noradrenaline and serotonin.	Norepinephrine	124-137	brain-derived neurotrophic factor	Rattus norvegicus	19-23
18310473-5	2008	We confirmed that TAAR1 was activated by dopamine, norepinephrine, and serotonin and demonstrated that TAAR1 signaling was attenuated by monoamine autoreceptors at exposure to dopamine, norepinephrine, and serotonin.	Norepinephrine	51-65	trace amine associated receptor 1	Homo sapiens	18-23
18310473-5	2008	We confirmed that TAAR1 was activated by dopamine, norepinephrine, and serotonin and demonstrated that TAAR1 signaling was attenuated by monoamine autoreceptors at exposure to dopamine, norepinephrine, and serotonin.	Norepinephrine	186-200	trace amine associated receptor 1	Homo sapiens	103-108
18310473-6	2008	In transfected cells, TAAR1 in response to dopamine, norepinephrine, and serotonin significantly inhibited uptake and promoted efflux of [3H]dopamine, [3H]norepinephrine, and [3H]serotonin, respectively, whereas the monoamine autoreceptors, D2s, alpha(2A), and 5-HT(1B) enhanced the uptake function under the same condition.	Norepinephrine	53-67	trace amine associated receptor 1	Homo sapiens	22-27
18310473-6	2008	In transfected cells, TAAR1 in response to dopamine, norepinephrine, and serotonin significantly inhibited uptake and promoted efflux of [3H]dopamine, [3H]norepinephrine, and [3H]serotonin, respectively, whereas the monoamine autoreceptors, D2s, alpha(2A), and 5-HT(1B) enhanced the uptake function under the same condition.	Norepinephrine	155-169	trace amine associated receptor 1	Homo sapiens	22-27
18065472-10	2008	Norepinephrine and dopamine occupy the same binding region, between TM3, TM5, and TM6, whereas the binding site of salbutamol is shifted toward TM4.	Norepinephrine	0-14	tropomyosin 3	Homo sapiens	68-71
18065472-10	2008	Norepinephrine and dopamine occupy the same binding region, between TM3, TM5, and TM6, whereas the binding site of salbutamol is shifted toward TM4.	Norepinephrine	0-14	tropomyosin 3	Homo sapiens	73-76
17853072-11	2008	These results suggest that systemic epinephrine, perhaps by evoking central norepinephrine release, modulates the increase in forebrain GABAA receptor binding induced by both insulin and stress.	Norepinephrine	76-90	gamma-aminobutyric acid type A receptor gamma3 subunit	Gallus gallus	136-150
18219438-1	2008	Our aim was to study fracture risk in users of various antidepressants (tricyclic antidepressants, selective serotonin reuptake inhibitors, and the group of other antidepressants including monoamine oxidase B inhibitors and drugs with effect on the norepinephrine system) and its relationship with effects on inhibition of the cholinergic and serotonin transporter system.	Norepinephrine	249-263	monoamine oxidase B	Homo sapiens	189-208
18056263-0	2008	Norepinephrine- and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytes.	Norepinephrine	0-14	adrenoceptor beta 2	Homo sapiens	49-67
19020660-11	2008	CONCLUSIONS: Our results show that the binding of apoB100-LDL to adipocytes via the LDL receptor inhibits intracellular noradrenaline-induced lipolysis in adipocytes.	Norepinephrine	120-133	low density lipoprotein receptor	Mus musculus	84-96
17726147-0	2007	Norepinephrine and rosiglitazone synergistically induce Elovl3 expression in brown adipocytes.	Norepinephrine	0-14	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3	Mus musculus	56-62
17726147-4	2007	By using primary cultures of brown adipocytes, we show here that the induced Elovl3 gene expression is synergistically regulated by norepinephrine and the peroxisome proliferator-activated receptor (PPAR) gamma ligand rosiglitazone.	Norepinephrine	132-146	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3	Mus musculus	77-83
17915260-3	2007	In isolated hippocampal neurons, norepinephrine (NE) application also increases the immunoreactivity of BDNF and several pro-survival signaling molecules.	Norepinephrine	33-47	brain derived neurotrophic factor	Homo sapiens	104-108
17557926-4	2007	We report the case of a 15-year-old girl with hypertension and a norepinephrine-secreting abdominal paraganglioma who was found to harbour a novel nonsense SDHC mutation, demonstrating that the clinical presentation of PGL3 syndrome can be more diverse than expected.	Norepinephrine	65-79	succinate dehydrogenase complex subunit C	Homo sapiens	156-160
17557926-4	2007	We report the case of a 15-year-old girl with hypertension and a norepinephrine-secreting abdominal paraganglioma who was found to harbour a novel nonsense SDHC mutation, demonstrating that the clinical presentation of PGL3 syndrome can be more diverse than expected.	Norepinephrine	65-79	succinate dehydrogenase complex subunit C	Homo sapiens	219-223
17565006-2	2007	Blockade of ectonucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) potentiates norepinephrine exocytosis, whereas recombinant soluble CD39 (solCD39) in-hibits it.	Norepinephrine	91-105	ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	12-60
17565006-2	2007	Blockade of ectonucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) potentiates norepinephrine exocytosis, whereas recombinant soluble CD39 (solCD39) in-hibits it.	Norepinephrine	91-105	ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	73-77
17827867-1	2007	The mechanism for noradrenaline (NA)-induced increases in intracellular Ca(2+) concentration ([Ca(2+)](i)) and physiological significance of Na(+) influx through receptor-operated channels (ROCs) and store-operated channels (SOCs) were studied in Chinese hamster ovary (CHO) cells stably expressing human alpha(1A)-adrenoceptor (alpha(1A)-AR).	Norepinephrine	18-31	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	305-313
17092970-2	2007	The purpose of the present study was to investigate whether the G196A polymorphism of the brain-derived neurotrophic factor (BDNF) gene is associated with the antidepressant effect of milnacipran, a serotonin norepinephrine reuptake inhibitor, and fluvoxamine, a selective serotonin reuptake inhibitor.	Norepinephrine	209-223	brain derived neurotrophic factor	Homo sapiens	90-123
17092970-2	2007	The purpose of the present study was to investigate whether the G196A polymorphism of the brain-derived neurotrophic factor (BDNF) gene is associated with the antidepressant effect of milnacipran, a serotonin norepinephrine reuptake inhibitor, and fluvoxamine, a selective serotonin reuptake inhibitor.	Norepinephrine	209-223	brain derived neurotrophic factor	Homo sapiens	125-129
17664853-0	2007	High plasma norepinephrine levels associated with beta2-adrenoceptor polymorphisms predict future renal damage in nonobese normotensive individuals.	Norepinephrine	12-26	adrenoceptor beta 2	Homo sapiens	50-68
17515698-12	2007	After administration of the COX 1 inhibitor SC 560, the arachidonic acid-induced vasopressor responses were significantly attenuated while U46619, angiotensin II, and norepinephrine-induced vasopressor, and PGE1-induced vasodepressor responses were not significantly altered.	Norepinephrine	167-181	cytochrome c oxidase subunit I	Felis catus	28-33
17515698-13	2007	After administration of the COX 2 inhibitor nimesulide, both the PGE 1 vasodepressor responses and arachidonic acid-induced vasopressor responses were significantly decreased while the U46619, angiotensin II, and norepinephrine-induced vasopressor responses were not significantly attenuated.	Norepinephrine	213-227	cytochrome c oxidase subunit II	Felis catus	28-33
16944358-1	2007	Endothelin (ET)-1 is an endogenous vasoconstrictor which modulates norepinephrine (NE) release in myocardial ischemia reperfusion.	Norepinephrine	67-81	endothelin-1	Cavia porcellus	0-17
17287506-2	2007	We report that genetic depletion of serotonin, dopamine, and norepinephrine in mice lacking the vesicular monoamine transporter (VMAT2 KO mice) causes an increase in cell death in the superficial layers of the cingulate and retrosplenial cortices during early postnatal life (postnatal days 0-4).	Norepinephrine	61-75	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	129-134
17331215-3	2007	In anaesthetized subjects, the concentration of extracellular noradrenaline in NK1R-/- mice was two-fourfold greater than in NK1R+/+ mice.	Norepinephrine	62-75	tachykinin receptor 1	Mus musculus	79-83
17331215-3	2007	In anaesthetized subjects, the concentration of extracellular noradrenaline in NK1R-/- mice was two-fourfold greater than in NK1R+/+ mice.	Norepinephrine	62-75	tachykinin receptor 1	Mus musculus	125-129
17331215-10	2007	It is concluded that the greater basal efflux of noradrenaline in NK1R-/- mice is explained by increased transmitter release, coupled with desensitization of somatodendritic alpha2a-adrenoceptors.	Norepinephrine	49-62	tachykinin receptor 1	Mus musculus	66-70
16788141-11	2006	We conclude that decreases in UT-A1, AQP2, and NKCC2/BSC1 proteins may contribute to the diuresis and natriuresis that occur following ANG II or norepinephrine-induced acute hypertension and do not appear to involve ANG II stimulation of aldosterone or thirst.	Norepinephrine	145-159	solute carrier family 12 member 1	Rattus norvegicus	47-52
16788141-11	2006	We conclude that decreases in UT-A1, AQP2, and NKCC2/BSC1 proteins may contribute to the diuresis and natriuresis that occur following ANG II or norepinephrine-induced acute hypertension and do not appear to involve ANG II stimulation of aldosterone or thirst.	Norepinephrine	145-159	solute carrier family 12 member 1	Rattus norvegicus	53-57
17027833-3	2006	This study examines the associations of beta2-adrenoceptor polymorphism with relationships between plasma norepinephrine (NE) and leptin to evaluate further the mechanisms of obesity.	Norepinephrine	106-120	adrenoceptor beta 2	Homo sapiens	40-58
16531006-9	2006	Furthermore, cotransfection of alpha2A-adrenergic receptor and APLP1 into HEK293 cells significantly increased norepinephrine mediated inhibition of adenylate cyclase activity.	Norepinephrine	111-125	adrenoceptor alpha 2A	Homo sapiens	31-58
16531006-9	2006	Furthermore, cotransfection of alpha2A-adrenergic receptor and APLP1 into HEK293 cells significantly increased norepinephrine mediated inhibition of adenylate cyclase activity.	Norepinephrine	111-125	amyloid beta precursor like protein 1	Homo sapiens	63-68
16388933-7	2006	Interestingly, exposure to a lower concentration (1 microM) of the antidepressants tended to increase T-cell-derived IL-10 production, with significant effects elicited by the noradrenaline reuptake inhibitors reboxetine and desipramine.	Norepinephrine	176-189	interleukin 10	Homo sapiens	117-122
16699769-1	2006	PURPOSE: The purpose of this study was to investigate the monoamine transporter status of dopamine, serotonin and norepinephrine throughout the brain in spinocerebellar ataxia type 2 (SCA2).	Norepinephrine	114-128	ataxin 2	Homo sapiens	153-182
16699769-1	2006	PURPOSE: The purpose of this study was to investigate the monoamine transporter status of dopamine, serotonin and norepinephrine throughout the brain in spinocerebellar ataxia type 2 (SCA2).	Norepinephrine	114-128	ataxin 2	Homo sapiens	184-188
16672216-7	2006	These changes likely result from increased sympathetic nervous system activity rather than adipose cell-autonomous effects, as we found that XLalphas is not normally expressed in adult adipose tissue, and Gnasxl(m+/p-) mice had increased urinary norepinephrine levels but not increased metabolic responsiveness to a beta3-adrenergic agonist.	Norepinephrine	246-260	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	Mus musculus	205-211
16774125-2	2006	However, N-type Ca2+ channel alpha1B-deficient mice with a CBA/JN background show normal plasma norepinephrine and epinephrine levels, presumably owing to compensation by other gene(s).	Norepinephrine	96-110	calcium channel, voltage-dependent, N type, alpha 1B subunit	Mus musculus	29-36
16774125-5	2006	These results suggest that the compensatory mechanisms to maintain normal levels of epinephrine and norepinephrine in the adrenal gland of N-type Ca2+ channel alpha1B-deficient mice include increased expression of alpha1A and beta4 subunits and increased catecholamine biosynthetic activity.	Norepinephrine	100-114	calcium channel, voltage-dependent, N type, alpha 1B subunit	Mus musculus	159-166
16531560-5	2006	Data will be discussed from studies involving the stimulation of the beta2 adrenergic receptor expressed on CD4+ T cells and B cells by norepinephrine or selective agonists.	Norepinephrine	136-150	adrenoceptor beta 2	Homo sapiens	69-94
16677282-8	2006	RESULTS: Norepinephrine stimulated the expression of S100A8/S100A9 mRNAs via beta-adrenergic receptors in U-937 cells and significantly increased calprotectin production to about 3.6-fold that of the control.	Norepinephrine	9-23	S100 calcium binding protein A9	Homo sapiens	60-66
16583235-2	2006	PPI is also disrupted by the norepinephrine alpha-1 agonist, cirazoline, and the PPI-disruptive effects of the indirect dopamine agonist amphetamine are opposed by the norepinephrine reuptake inhibitor, desipramine.	Norepinephrine	29-43	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	44-51
16495759-2	2006	In this study we explored whether neurotensin, a neuropeptide found in heart tissue, could modify myocardial norepinephrine release in spontaneously hypertensive rats (SHR).	Norepinephrine	109-123	neurotensin	Rattus norvegicus	34-45
16495759-4	2006	Neurotensin increased coronary effluent norepinephrine concentrations and induced positive inotropic responses, effects that were enhanced in spontaneously hypertensive rats compared with Wistar Kyoto rats.	Norepinephrine	40-54	neurotensin	Rattus norvegicus	0-11
16495759-8	2006	In summary, in the hypertensive heart there is an increased sensitivity to neurotensin"s actions on myocardial norepinephrine release and subsequent contractile changes.	Norepinephrine	111-125	neurotensin	Rattus norvegicus	75-86
16183708-0	2006	Induction of beta3-adrenergic receptor functional expression following chronic stimulation with noradrenaline in neonatal rat cardiomyocytes.	Norepinephrine	96-109	adrenoceptor beta 3	Rattus norvegicus	13-38
16213535-1	2006	Nicotinic acetylcholine receptor (nAChR)-evoked release of norepinephrine (NE) has been demonstrated in a number of brain regions that receive sole noradrenergic innervation from the locus coeruleus (LC).	Norepinephrine	59-73	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	0-32
16213535-1	2006	Nicotinic acetylcholine receptor (nAChR)-evoked release of norepinephrine (NE) has been demonstrated in a number of brain regions that receive sole noradrenergic innervation from the locus coeruleus (LC).	Norepinephrine	59-73	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	34-39
16099895-1	2005	Existing evidence suggests that neuropeptide Y (NPY) acts as a neurotransmitter in vascular smooth muscle and is coreleased with norepinephrine from sympathetic nerves.	Norepinephrine	129-143	neuropeptide Y	Canis lupus familiaris	32-46
16099895-1	2005	Existing evidence suggests that neuropeptide Y (NPY) acts as a neurotransmitter in vascular smooth muscle and is coreleased with norepinephrine from sympathetic nerves.	Norepinephrine	129-143	neuropeptide Y	Canis lupus familiaris	48-51
16237719-9	2005	In the medial prefrontal cortex of AQP4-knockout mice, the levels of serotonin and norepinephrine were increased, but no significant change in dopamine level was found.	Norepinephrine	83-97	aquaporin 4	Mus musculus	35-39
16280290-0	2005	Rebound weight gain as associated with high plasma norepinephrine levels that are mediated through polymorphisms in the beta2-adrenoceptor.	Norepinephrine	51-65	adrenoceptor beta 2	Homo sapiens	120-138
16869081-0	2005	[Effects of endogenous endothelin 1 on norepinephrine release and arrhythmia in cardiac ischemia and reperfusion--a study by Langendorff perfusion system using the heart excised from a guinea pig].	Norepinephrine	39-53	endothelin-1	Cavia porcellus	23-35
15855229-3	2005	In cultured brown adipocytes, a mixture of norepinephrine, dexamethasone, and the PPARalpha ligand Wy-14643, which rendered the adipocytes a high oxidative state, was required for substantial induction of Elovl3 expression, whereas the same treatment suppressed Elovl1 mRNA levels.	Norepinephrine	43-57	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3	Mus musculus	205-211
15855229-3	2005	In cultured brown adipocytes, a mixture of norepinephrine, dexamethasone, and the PPARalpha ligand Wy-14643, which rendered the adipocytes a high oxidative state, was required for substantial induction of Elovl3 expression, whereas the same treatment suppressed Elovl1 mRNA levels.	Norepinephrine	43-57	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1	Mus musculus	262-268
15894570-3	2005	However, NGF also facilitates synaptic transmission and norepinephrine uptake, effects that would be expected to restrain such deleterious outcomes.	Norepinephrine	56-70	nerve growth factor	Mus musculus	9-12
15894570-10	2005	In conclusion, overexpression of NGF in heart leads to sympathetic hyperinnervation that is not associated with detrimental effects on LV performance and is likely due to concomitantly enhanced norepinephrine neuronal uptake.	Norepinephrine	194-208	nerve growth factor	Mus musculus	33-36
16159376-6	2005	The number of double-labelled tyrosine hydroxylase/Fos immunoreactive neurones in locus coeruleus was significantly higher at 14.00 h of oestrus, suggesting an increase in its activity preceding the prolactin surge that generally occurs at 15.00 h. Therefore, the increase in locus coeruleus activity on the afternoon of oestrus supports the data obtained with bilateral lesion of this nucleus, suggesting a stimulatory role of locus coeruleus norepinephrine in the genesis of the secondary surge of prolactin.	Norepinephrine	444-458	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	51-54
16154127-2	2005	Exogenous neurotensin evoked contractile responses in isolated ventricular preparations, which were equivalent in magnitude to those of norepinephrine and histamine, but greater than those for serotonin and angiotensin II.	Norepinephrine	136-150	neurotensin	Rattus norvegicus	10-21
16154127-6	2005	Neurotensin elicited an increase in coronary effluent norepinephrine concentrations, and a strong relationship between the magnitude of neurotensin-induced contractile effects and increments in myocardial norepinephrine release were noted.	Norepinephrine	54-68	neurotensin	Rattus norvegicus	0-11
16154127-6	2005	Neurotensin elicited an increase in coronary effluent norepinephrine concentrations, and a strong relationship between the magnitude of neurotensin-induced contractile effects and increments in myocardial norepinephrine release were noted.	Norepinephrine	54-68	neurotensin	Rattus norvegicus	136-147
16154127-6	2005	Neurotensin elicited an increase in coronary effluent norepinephrine concentrations, and a strong relationship between the magnitude of neurotensin-induced contractile effects and increments in myocardial norepinephrine release were noted.	Norepinephrine	205-219	neurotensin	Rattus norvegicus	0-11
16154127-6	2005	Neurotensin elicited an increase in coronary effluent norepinephrine concentrations, and a strong relationship between the magnitude of neurotensin-induced contractile effects and increments in myocardial norepinephrine release were noted.	Norepinephrine	205-219	neurotensin	Rattus norvegicus	136-147
15970488-10	2005	The sympathetic nervous system and gut-derived norepinephrine mediate the pro-inflammatory effects by activating alpha2A-adrenoceptor on Kupffer cells.	Norepinephrine	47-61	adrenoceptor alpha 2A	Homo sapiens	113-133
16292510-0	2005	Muller Cells as a source of brain-derived neurotrophic factor in the retina: noradrenaline upregulates brain-derived neurotrophic factor levels in cultured rat Muller cells.	Norepinephrine	77-90	brain-derived neurotrophic factor	Rattus norvegicus	28-61
16292510-0	2005	Muller Cells as a source of brain-derived neurotrophic factor in the retina: noradrenaline upregulates brain-derived neurotrophic factor levels in cultured rat Muller cells.	Norepinephrine	77-90	brain-derived neurotrophic factor	Rattus norvegicus	103-136
16292510-6	2005	Noradrenaline administration caused an upregulation of BDNF mRNA and protein expression by cultured Muller cells.	Norepinephrine	0-13	brain-derived neurotrophic factor	Rattus norvegicus	55-59
16282996-3	2005	Our results suggest that trophic function of acetylcholine and norepinephrine is associated with regulation of Na,K-ATPase activity as a signal transducer.	Norepinephrine	63-77	ATPase Na+/K+ transporting subunit alpha 1	Gallus gallus	111-122
16087140-1	2005	We have documented a pre-junctional beta-2 adrenoceptor mediated reduction in cardiac norepinephrine spillover (CNES) in heart failure patients receiving chronic beta-blockade.	Norepinephrine	86-100	adrenoceptor beta 2	Homo sapiens	36-55
15888529-0	2005	Inhibition of perforant path input to the CA1 region by serotonin and noradrenaline.	Norepinephrine	70-83	carbonic anhydrase 1	Homo sapiens	42-45
15888529-1	2005	Bath-applied monoamines-dopamine (DA), serotonin (5-HT), and noradrenaline (NE)-strongly suppress the perforant path (PP) input to CA1 hippocampal region with very little effect on the Schaffer collaterals (SC) input.	Norepinephrine	61-74	carbonic anhydrase 1	Homo sapiens	131-134
16036433-6	2005	The results of autonomic function tests were not different between patients treated with BDNF and placebo, but norepinephrine levels were higher in the BDNF group.	Norepinephrine	111-125	brain derived neurotrophic factor	Homo sapiens	152-156
16036433-8	2005	The elevation of norepinephrine levels might reflect a non-specific up-regulation, and its association with BDNF an autocrine effect.	Norepinephrine	17-31	brain derived neurotrophic factor	Homo sapiens	108-112
15944024-3	2005	It is possible that such a function may be revealed by examining the interaction of GAL with norepinephrine (NE), with which it is prominently co-localized.	Norepinephrine	93-107	galanin and GMAP prepropeptide	Homo sapiens	84-87
15756641-4	2005	beta2AR activation by epinephrine, norepinephrine, and salbutamol suppressed the IgE receptor-dependent release of histamine, lipid mediators, and TNF-alpha, and inhibited SCF-dependent MC proliferation and migration.	Norepinephrine	35-49	adrenoceptor beta 2	Homo sapiens	0-7
15756641-4	2005	beta2AR activation by epinephrine, norepinephrine, and salbutamol suppressed the IgE receptor-dependent release of histamine, lipid mediators, and TNF-alpha, and inhibited SCF-dependent MC proliferation and migration.	Norepinephrine	35-49	KIT ligand	Homo sapiens	172-175
15615865-7	2005	In functional studies, coexpression with beta2-AR significantly enhanced the coupling of alpha1D-AR to norepinephrine-stimulated Ca2+ mobilization.	Norepinephrine	103-117	adrenoceptor beta 2	Homo sapiens	41-49
16097416-1	2005	OBJECTIVE: To examine if the decline in post-ischemic hyperemic flow after repeated brief periods of myocardial ischemia is accompanied by augmented cardiac release of the vasoconstrictors endothelin-1 (ET-1) and norepinephrine (NE).	Norepinephrine	213-227	endothelin-1	Sus scrofa	203-207
15762558-0	2005	Dopamine-, L-DOPA-, adrenaline-, and noradrenaline-induced growth of Au nanoparticles: assays for the detection of neurotransmitters and of tyrosinase activity.	Norepinephrine	37-50	tyrosinase	Homo sapiens	140-150
15652511-3	2005	Here, we demonstrate stimulations with GPCR agonists (norepinephrine, angiotensin II, and endothelin 1) and phorbol ester activated and translocated protein kinase D1 (PKD1) to the Z-discs in neonatal rat cardiomyocytes in a protein kinase C (PKC)-dependent manner, whereas gp130 agonist did not.	Norepinephrine	54-68	protein kinase D1	Rattus norvegicus	149-166
15548235-9	2004	In contrast, very high positive correlation was observed between noradrenaline level and L(max)-DBP (r = 0.59; P = 0.0005) or L(max)-SBP (r = 0.53; P &lt; 0.002).	Norepinephrine	65-78	D-box binding PAR bZIP transcription factor	Rattus norvegicus	96-99
15126242-9	2004	The glucagon and norepinephrine responses to insulin-induced hypoglycemia are blunted in late pregnancy in the dog, impacting on the magnitude of the metabolic responses to the fall in glucose.	Norepinephrine	17-31	insulin	Canis lupus familiaris	45-52
15322265-1	2004	The neurotoxin 1-methyl-4-(2"-aminophenyl)-1,2,3,6-tetrahydropyridine (2"-NH(2)-MPTP) damages forebrain serotonin (5-HT) and norepinephrine (NE) nerve terminals while sparing striatal dopaminergic innervation.	Norepinephrine	125-139	protein tyrosine phosphatase, non-receptor type 2	Mus musculus	80-84
15308313-0	2004	Soluble beta-amyloid (A beta) 40 causes attenuation or potentiation of noradrenaline-induced vasoconstriction in rats depending upon the concentration employed.	Norepinephrine	71-84	amyloid beta precursor protein	Rattus norvegicus	8-28
15249992-7	2004	Moreover, Western blot analysis revealed a peak expression of c-fos in the right and left ventricles after naloxone-precipitated withdrawal in parallel with an increase in noradrenaline (NA) turnover.	Norepinephrine	172-185	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	62-67
15125834-1	2004	Norepinephrine released by the sympathetic nerve terminals regulates the immune system primarily via its stimulation of beta(2)-adrenergic receptor (beta(2)AR), but the underlying molecular mechanisms remain to be elicited.	Norepinephrine	0-14	adrenoceptor beta 2	Homo sapiens	120-147
15125834-1	2004	Norepinephrine released by the sympathetic nerve terminals regulates the immune system primarily via its stimulation of beta(2)-adrenergic receptor (beta(2)AR), but the underlying molecular mechanisms remain to be elicited.	Norepinephrine	0-14	adrenoceptor beta 2	Homo sapiens	149-158
15009661-6	2004	We found that the levels of noradrenaline were significantly increased in the limbic forebrain of TTR-null mice.	Norepinephrine	28-41	transthyretin	Mus musculus	98-101
14678390-3	2004	The potency and intrinsic activity of amidephrine and Ro 115-1240 relative to noradrenaline were determined in native and cell-based assays using human recombinant alpha1-ARs; they acted as selective alpha1A/1L-AR full and partial agonists, respectively.	Norepinephrine	78-91	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	200-207
15017115-10	2004	CONCLUSION: These results reveal that glucose able to induce hypertension and provide evidence that glucose inhibits the transcriptions of both 11beta-HSD2 and CYP 11B2 in vasculature, leading to lower aldosterone and higher corticosterone production in vessels, and increased vasoconstrictor responses to norepinephrine.	Norepinephrine	306-320	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	144-155
15017115-10	2004	CONCLUSION: These results reveal that glucose able to induce hypertension and provide evidence that glucose inhibits the transcriptions of both 11beta-HSD2 and CYP 11B2 in vasculature, leading to lower aldosterone and higher corticosterone production in vessels, and increased vasoconstrictor responses to norepinephrine.	Norepinephrine	306-320	cytochrome P450, family 11, subfamily b, polypeptide 2	Rattus norvegicus	160-168
14709821-5	2003	In the aortae isolated from both CD38(+/+) and CD38(-/-) mice, KCl, phenylephrine and norepinephrine induced concentration-dependent contraction.	Norepinephrine	86-100	CD38 antigen	Mus musculus	33-37
14709821-5	2003	In the aortae isolated from both CD38(+/+) and CD38(-/-) mice, KCl, phenylephrine and norepinephrine induced concentration-dependent contraction.	Norepinephrine	86-100	CD38 antigen	Mus musculus	47-51
14709821-8	2003	Phenylephrine- and norepinephrine-induced contractions were, however, significantly smaller in the aortae from CD38(-/-) mice than in those from CD38(+/+) mice.	Norepinephrine	19-33	CD38 antigen	Mus musculus	111-115
14709821-8	2003	Phenylephrine- and norepinephrine-induced contractions were, however, significantly smaller in the aortae from CD38(-/-) mice than in those from CD38(+/+) mice.	Norepinephrine	19-33	CD38 antigen	Mus musculus	145-149
12820982-0	2003	Implication of ionotropic glutamate receptors in the release of noradrenaline in hippocampal CA1 and CA3 subregions under oxygen and glucose deprivation.	Norepinephrine	64-77	carbonic anhydrase 1	Homo sapiens	93-96
12820982-5	2003	Maximum effect on noradrenaline release was observed in CA1 region.	Norepinephrine	18-31	carbonic anhydrase 1	Homo sapiens	56-59
12820982-9	2003	The AMPA receptor antagonist GYKI-53784 had no effect in CA3, but partly reduced noradrenaline release in CA1.	Norepinephrine	81-94	carbonic anhydrase 1	Homo sapiens	106-109
12820982-10	2003	Our results suggest that ionotropic glutamate receptors seem to be implicated in the massive cytoplasmic release of noradrenaline in CA1 what may contribute to its selective vulnerability.	Norepinephrine	116-129	carbonic anhydrase 1	Homo sapiens	133-136
14612195-3	2003	We have found that neuraminidase completely abolish the inhibitory effect of ACP-1 on dopamine release, while the inhibitory activity of ACP-1 on norepinephrine release is partially lost.	Norepinephrine	146-160	acid phosphatase 1	Rattus norvegicus	137-142
14499136-0	2003	Phenylephrine and norepinephrine increase dopamine transporter ligand binding in striatum.	Norepinephrine	18-32	solute carrier family 6 member 3	Homo sapiens	42-62
12736175-3	2003	In the present study, we tested the hypothesis that norepinephrine (NE) is necessary for satiety induced by peripheral CCK-8 by using mice lacking dopamine beta-hydroxylase (Dbh(-/-)), the enzyme responsible for synthesizing NE and epinephrine from dopamine.	Norepinephrine	52-66	cholecystokinin	Mus musculus	119-122
12727985-4	2003	Adipocytes of PCOS women were about 25% larger than in the controls (P &lt; 0.05) and had 40% reduced noradrenaline-induced lipolysis (P &lt; 0.05), which could be attributed to a 10-fold decreased beta(2)-adrenoceptor sensitivity (P &lt; 0.05) and low ability of cAMP to activate the protein kinase A (PKA)/hormone-sensitive lipase (HSL) complex (P &lt; 0.05).	Norepinephrine	102-115	lipase E, hormone sensitive type	Homo sapiens	334-337
12578875-6	2003	Baseline ST2 levels were correlated with baseline B-type natriuretic peptide (BNP) levels (r=0.36, P&lt;0.0001), baseline proatrial natriuretic peptide (ProANP) levels (r=0.36, P&lt;0.0001), and baseline norepinephrine levels (r=0.39, P&lt;0.0001).	Norepinephrine	204-218	ST2	Homo sapiens	9-12
12538816-3	2003	In the present study, we found that norepinephrine, epinephrine, or isoproterenol down-regulated IL-18 (100 ng/ml)-induced intercellular adhesion molecule (ICAM)-1 expression on monocytes in a dose-dependent manner (10(-8)-10(-4) M), but did not effect B7.1 and B7.2 expression after 24-h incubation.	Norepinephrine	36-50	interleukin 18	Homo sapiens	97-102
12538816-3	2003	In the present study, we found that norepinephrine, epinephrine, or isoproterenol down-regulated IL-18 (100 ng/ml)-induced intercellular adhesion molecule (ICAM)-1 expression on monocytes in a dose-dependent manner (10(-8)-10(-4) M), but did not effect B7.1 and B7.2 expression after 24-h incubation.	Norepinephrine	36-50	intercellular adhesion molecule 1	Homo sapiens	137-163
12538816-6	2003	In the same manner, salbutanol and terbutaline as well as norepinephrine, epinephrine, and isoproterenol regulated the IL-18-induced cytokine production, including IL-12, tumor necrosis factor-alpha or interferon-gamma through the stimulation of beta 2-AR.	Norepinephrine	58-72	interleukin 18	Homo sapiens	119-124
12688395-4	2003	Meanwhile, activation of the alpha1b-adrenoceptor through increased interstitial noradrenaline by ischemic preconditioning is also associated with the ischemic preconditioning effect.	Norepinephrine	81-94	alpha-1B adrenergic receptor	Oryctolagus cuniculus	29-49
12478197-11	2003	Norepinephrine depolarized the membrane and elicited oscillatory potentials with an associated elevation in [Ca2+].	Norepinephrine	0-14	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	109-112
12478197-16	2003	Neurally released norepinephrine and ATP are increased [Ca2+] by the influx of Ca2+ through L-type Ca2+ channels and also by the release of Ca2+ from internal stores.	Norepinephrine	18-32	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	56-59
12478197-16	2003	Neurally released norepinephrine and ATP are increased [Ca2+] by the influx of Ca2+ through L-type Ca2+ channels and also by the release of Ca2+ from internal stores.	Norepinephrine	18-32	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	79-82
12478197-16	2003	Neurally released norepinephrine and ATP are increased [Ca2+] by the influx of Ca2+ through L-type Ca2+ channels and also by the release of Ca2+ from internal stores.	Norepinephrine	18-32	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	79-82
12478197-16	2003	Neurally released norepinephrine and ATP are increased [Ca2+] by the influx of Ca2+ through L-type Ca2+ channels and also by the release of Ca2+ from internal stores.	Norepinephrine	18-32	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	79-82
12585694-2	2002	We have previously reported that atrial natriuretic factor (ANF) decreases neuronal norepinephrine (NE) release.	Norepinephrine	84-98	natriuretic peptide A	Rattus norvegicus	33-58
12585694-2	2002	We have previously reported that atrial natriuretic factor (ANF) decreases neuronal norepinephrine (NE) release.	Norepinephrine	84-98	natriuretic peptide A	Rattus norvegicus	60-63
12502025-1	2002	Detection of two biogenic amine neurotransmitters, serotonin (5-HT) and norepinephrine (NE) within the CA1 region of the hippocampus (HPC) of behaving male laboratory animals (Rattus norvegicus), was performed with miniature carbon sensors (BRODERICK PROBES) and in vivo semidifferential microvoltammetry after acute administration of the soluble immune factor, human recombinant, interleukin (IL) 1alpha (10 and 100 ng/kg i.p.).	Norepinephrine	72-86	carbonic anhydrase 1	Homo sapiens	103-106
12866809-4	2002	In some tissues alpha1A- or alpha1D-adrenoceptors were "protected" from inactivation by incubation in the presence of the selective alpha1A- or 1D-adrenoceptor antagonists 5-methylurapidil and BMY 7378 before recording further responses to noradrenaline.	Norepinephrine	240-253	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	16-23
12866809-4	2002	In some tissues alpha1A- or alpha1D-adrenoceptors were "protected" from inactivation by incubation in the presence of the selective alpha1A- or 1D-adrenoceptor antagonists 5-methylurapidil and BMY 7378 before recording further responses to noradrenaline.	Norepinephrine	240-253	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	132-139
12242714-1	2002	There are three subtypes of alpha2 adrenoceptor, i.e., alpha2A, alpha2B, and alpha2C, mediating the specific effect of epinephrine and norepinephrine in various tissues by means of G protein-coupled signal transduction pathways.	Norepinephrine	135-149	adrenergic receptor, alpha 2c	Mus musculus	77-84
12239109-0	2002	Expression of estrogen receptor-alpha and cFos in norepinephrine and epinephrine neurons of young and middle-aged rats during the steroid-induced luteinizing hormone surge.	Norepinephrine	50-64	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	42-46
12596890-2	2002	Three endogenous natriuretic peptide ligands (natriuretic peptide, ANP; brain natriuretic peptide, BNP; C-type natriuretic peptide, CNP) produced a concentration-dependent relaxation in de-endothelialized guinea-pig aorta pre-contracted by noradrenaline (NA), with a potency order of ANP &gt; or = BNP &gt;&gt; CNP.	Norepinephrine	240-253	2',3'-cyclic-nucleotide 3'-phosphodiesterase	Cavia porcellus	132-135
12170059-0	2002	Nicotinic acetylcholine receptor regulation of spinal norepinephrine release.	Norepinephrine	54-68	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	0-32
12170059-3	2002	This study tested whether nAChR agonists stimulate spinal release of the neurotransmitter norepinephrine either by direct actions on noradrenergic terminals or indirectly by stimulating release of other neurotransmitters to induce norepinephrine release.	Norepinephrine	90-104	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	26-31
11916794-2	2002	To study the effects of tramadol on norepinephrine transporter (NET) function, we assayed the effect of tramadol on [3H]-norepinephrine ([3H]-NE) uptake and [3H]-desipramine binding to plasma membranes isolated from bovine adrenal medulla.	Norepinephrine	36-50	solute carrier family 6 member 2	Bos taurus	64-67
11985823-5	2002	Comparison of synaptosomal and slice preparations, as well as examination of the effects of tetrodotoxin, indicated that at least two nicotinic acetylcholine receptor populations regulated [(3)H]norepinephrine release from neonatal and adult hippocampus; one localized on noradrenergic terminals, the other on adjacent cells.	Norepinephrine	195-209	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	134-166
11880481-0	2002	Activation by serotonin and noradrenaline of vasopressin and oxytocin expression in the mouse paraventricular and supraoptic nuclei.	Norepinephrine	28-41	oxytocin	Mus musculus	61-69
11880481-1	2002	Noradrenaline and serotonin are known to control arginine-vasopressin (AVP) and oxytocin (OT) secretion in the systemic circulation.	Norepinephrine	0-13	oxytocin	Mus musculus	80-88
12361188-1	2002	OBJECTIVE: Since beta2-adrenergic receptors (beta2AR) can influence blood pressure not only by vasodilation, but also participate in noradrenaline release from sympathetic nerve endings, we have studied whether Arg16Gly polymorphism of the beta2AR gene is associated with predisposition to essential hypertension and increased plasma noradrenaline concentration in offspring from normotensive (SN) and hypertensive parents (SH).	Norepinephrine	133-146	adrenoceptor beta 2	Homo sapiens	17-43
12361188-1	2002	OBJECTIVE: Since beta2-adrenergic receptors (beta2AR) can influence blood pressure not only by vasodilation, but also participate in noradrenaline release from sympathetic nerve endings, we have studied whether Arg16Gly polymorphism of the beta2AR gene is associated with predisposition to essential hypertension and increased plasma noradrenaline concentration in offspring from normotensive (SN) and hypertensive parents (SH).	Norepinephrine	133-146	adrenoceptor beta 2	Homo sapiens	45-52
12361188-1	2002	OBJECTIVE: Since beta2-adrenergic receptors (beta2AR) can influence blood pressure not only by vasodilation, but also participate in noradrenaline release from sympathetic nerve endings, we have studied whether Arg16Gly polymorphism of the beta2AR gene is associated with predisposition to essential hypertension and increased plasma noradrenaline concentration in offspring from normotensive (SN) and hypertensive parents (SH).	Norepinephrine	334-347	adrenoceptor beta 2	Homo sapiens	17-43
11799094-5	2002	The norepinephrine-induced increase in 8-epi-PGF(2alpha) levels could be completely normalized by 3 different classes of antihypertensive drugs: prazosin, an alpha-adrenergic receptor blocker; hydralazine, a nonspecific vasodilator; and losartan, a specific angiotensin type 1 (AT(1)) receptor antagonist.	Norepinephrine	4-18	placental growth factor	Rattus norvegicus	45-48
11799094-8	2002	In summary, continuous infusion of both Ang II and norepinephrine potently increases plasma levels of 8-epi-PGF(2alpha) and thus in vivo oxidative stress.	Norepinephrine	51-65	placental growth factor	Rattus norvegicus	108-111
11799094-9	2002	Ang II and norepinephrine seem to induce this increase in 8-epi-PGF(2alpha) via mechanisms with different pressor dependencies.	Norepinephrine	11-25	placental growth factor	Rattus norvegicus	64-67
12448081-8	2002	The co-localization of GAL and dopamine beta-hydroxylase (D beta H--a key enzyme of the noradrenaline synthesis pathway) in perivascular nerve fibers could lead to considerable vasospasms in the pancreas, resulting in deeper hypoxia of the organ.	Norepinephrine	88-101	galanin and GMAP prepropeptide	Homo sapiens	23-26
11739254-10	2001	Locally administered gastrin-17 and sulfated cholecystokinin-8 mobilized histamine as did pituitary adenylate cyclase-activating peptide-27, vasoactive intestinal peptide, peptide YY, met-enkephalin, endothelin and noradrenaline, adrenaline and isoprenaline.	Norepinephrine	215-228	gastrin	Rattus norvegicus	21-28
11739254-12	2001	While gastrin, sulfated-cholecystokinin-8, met-enkephalin and isoprenaline induced a sustained elevation of the submucosal histamine concentration, endothelin, peptide YY, pituitary adenylate cyclase activating peptide, vasoactive intestinal peptide, noradrenaline and adrenaline induced a transient elevation.	Norepinephrine	251-264	gastrin	Rattus norvegicus	6-13
11677361-5	2001	RESULTS: Increases in medial cell number and accumulation of collagen and elastin characterized norepinephrine-induced aortic remodeling.	Norepinephrine	96-110	elastin	Rattus norvegicus	74-81
11602687-8	2001	Prazosin, 5-methyl-urapidil, and 2-[2,6-dimethoxyphenoxyethyl]aminomethyl)-1,4-benzodioxane (WB 4101) shifted the potency of norepinephrine concentration dependently giving pA2 values of 9.4, 8.9, and 10.1, respectively, showing the presence of the alpha1A-subtype in these arteries.	Norepinephrine	125-139	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	249-256
12030814-6	2001	In the striatum, CART(62-76) decreased the levels of noradrenaline and 5-HT.	Norepinephrine	53-66	CART prepropeptide	Rattus norvegicus	17-21
11676206-4	2001	The present results suggest that the two endocannabinoids may oppositely participate in the CB1-receptor-mediated modulation of sympathetic norepinephrine release.	Norepinephrine	140-154	cannabinoid receptor 1	Rattus norvegicus	92-95
11677796-2	2001	The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3).	Norepinephrine	45-58	calcium channel, voltage-dependent, N type, alpha 1B subunit	Mus musculus	190-198
11677796-2	2001	The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3).	Norepinephrine	45-58	adrenergic receptor, alpha 2c	Mus musculus	256-264
11677796-2	2001	The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3).	Norepinephrine	45-58	hemoglobin, beta adult minor chain	Mus musculus	300-314
11677796-8	2001	The release of noradrenaline from sympathetic nerves is controlled by presynaptic alpha 2A- and alpha 2C-receptors.	Norepinephrine	15-28	adrenergic receptor, alpha 2c	Mus musculus	96-104
11373287-2	2001	Botulinum neurotoxin E cleaves the C-terminal coil of SNAP-25, inhibiting exocytosis of norepinephrine from permeabilized PC12 cells.	Norepinephrine	88-102	synaptosome associated protein 25	Rattus norvegicus	54-61
11429392-11	2001	These results show that contractile responses to noradrenaline in human skeletal muscle resistance arteries are predominantly mediated by the alpha(1A)-adrenoceptor subtype with a minor population of an unknown alpha(1)-adrenoceptor subtype.	Norepinephrine	49-62	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	142-150
11427501-0	2001	Antiproliferative action of dopamine and norepinephrine in neuroblastoma cells expressing the human dopamine transporter.	Norepinephrine	41-55	solute carrier family 6 member 3	Homo sapiens	100-120
11413241-1	2001	It has previously been shown that nicotine-evoked dopamine release from rat striatal synaptosomes and nicotine-evoked norepinephrine release from hippocampal synaptosomes are mediated by distinct nicotinic acetylcholine receptor (nAChR) subtypes.	Norepinephrine	118-132	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	196-228
11413241-1	2001	It has previously been shown that nicotine-evoked dopamine release from rat striatal synaptosomes and nicotine-evoked norepinephrine release from hippocampal synaptosomes are mediated by distinct nicotinic acetylcholine receptor (nAChR) subtypes.	Norepinephrine	118-132	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	230-235
11278912-0	2001	Phospholipase D activation by norepinephrine is mediated by 12(s)-, 15(s)-, and 20-hydroxyeicosatetraenoic acids generated by stimulation of cytosolic phospholipase a2.	Norepinephrine	30-44	cytosolic phospholipase A2	Oryctolagus cuniculus	141-167
11259564-5	2001	The antinociceptive potency of [Dmt1]DALDA far exceeded its affinity and potency at the mu-opioid receptor and may be explained by its ability to inhibit norepinephrine (NE) uptake in spinal cord synaptosomes.	Norepinephrine	154-168	RoBo-1	Rattus norvegicus	32-36
11153756-12	2001	In the presence of norepinephrine, inhibition of beta1-adrenoceptors increased the amount of protein kinase C-alpha and -delta isoforms translocated into the particulate fraction.	Norepinephrine	19-33	protein kinase C, alpha	Rattus norvegicus	93-126
11104823-3	2000	We have studied the effect of CART peptide-(55-102) and TRH on basal and depolarization (K+ 15 mM)-induced norepinephrine and dopamine release from rat hypothalamic neuronal endings (synaptosomes) in vitro.	Norepinephrine	107-121	CART prepropeptide	Rattus norvegicus	30-34
11046223-14	2000	The interaction of intravenous anesthetics with NET may modulate the neuronal transmission of norepinephrine during anesthesia.	Norepinephrine	94-108	solute carrier family 6 member 2	Bos taurus	48-51
11196449-2	2000	Noradrenaline, octopamine and Compound A inhibited the type I DOC induced difference spectrum of P450c11 and elicited a type II difference spectrum when added alone.	Norepinephrine	0-13	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	97-104
11003990-5	2000	The binding capacity of NK cells to a CD44 ligand, hyaluronate, was reduced by the stimulation with norepinephrine (P &lt; 0.01).	Norepinephrine	100-114	CD44 molecule (Indian blood group)	Homo sapiens	38-42
11003990-6	2000	The intravenous injection of norepinephrine in mice decreased the expression of CD44 and CD18 on CD3(-)NK1.1(+) cells (P &lt; 0.01) and increased the number of CD3(-)NK1.1(+) cells in PBMC (P &lt; 0.01).	Norepinephrine	29-43	CD44 antigen	Mus musculus	80-84
10893647-10	2000	Functional affinity of each antagonist suggested that noradrenaline-induced contractions were mainly mediated by alpha 1L-AR in the human prostate and by alpha 1B-AR in the mesenteric artery.	Norepinephrine	54-67	adrenoceptor alpha 1B	Homo sapiens	154-165
11021986-0	2000	Effect of corticotropin releasing factor receptor 1 antagonist on extracellular norepinephrine, dopamine and serotonin in hippocampus and prefrontal cortex of rats in vivo.	Norepinephrine	80-94	corticotropin releasing hormone receptor 1	Rattus norvegicus	10-51
10843184-5	2000	Only nocturnal urinary norepinephrine excretion could explain a significant fraction of the variability in both UCP2 and UCP3 expression in muscle, but not adipose tissue.	Norepinephrine	23-37	uncoupling protein 3	Homo sapiens	121-125
10652114-3	2000	NPY produced a concentration-dependent inhibition in fast ESP amplitude in the majority of neurones (17/21) with a calculated IC50 value of 7 nM; in some neurones this inhibition was mediated via the local release of noradrenaline.	Norepinephrine	217-230	pro-neuropeptide Y	Cavia porcellus	0-3
11263248-7	2000	Treatment with norepinephrine (NE) in the presence of propranolol for 24 h increased DNA synthesis in HEK293/alpha 1A- or HEK293/alpha 1B-AR cells concentration-dependently, with EC50 values of 48.8 nmol.L-1 (95% confidence limits 9.7-246 nmol.L-1) and 8.4 nmol.L-1 (95% confidence limits 2.1-32.9 nmol.L-1), respectively.	Norepinephrine	15-29	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	109-117
11263248-7	2000	Treatment with norepinephrine (NE) in the presence of propranolol for 24 h increased DNA synthesis in HEK293/alpha 1A- or HEK293/alpha 1B-AR cells concentration-dependently, with EC50 values of 48.8 nmol.L-1 (95% confidence limits 9.7-246 nmol.L-1) and 8.4 nmol.L-1 (95% confidence limits 2.1-32.9 nmol.L-1), respectively.	Norepinephrine	15-29	adrenoceptor alpha 1B	Homo sapiens	129-140
10714892-8	2000	These data suggest that the alpha1A/L-adrenoceptor mediates primarily those responses to noradrenaline in this artery.	Norepinephrine	89-102	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	28-35
11452226-5	2000	RESULTS: We found that 1) noradrenaline, 10-5 M, 10-6 M, and 10-7 M, significantly suppressed the production of IFNgamma and that noradrenaline, 10-5 M, significantly enhanced the production of IL-10.	Norepinephrine	26-39	interleukin 10	Homo sapiens	194-199
11452226-5	2000	RESULTS: We found that 1) noradrenaline, 10-5 M, 10-6 M, and 10-7 M, significantly suppressed the production of IFNgamma and that noradrenaline, 10-5 M, significantly enhanced the production of IL-10.	Norepinephrine	130-143	interleukin 10	Homo sapiens	194-199
11452226-7	2000	Noradrenaline, 10-5 M and 10-6 M, and clonidine, 10-5 M, significantly suppressed the IFNgamma/IL-10 production ratio.	Norepinephrine	0-13	interleukin 10	Homo sapiens	95-100
10651063-0	1999	Atrial natriuretic factor inhibits norepinephrine biosynthesis and turnover in the rat hypothalamus.	Norepinephrine	35-49	natriuretic peptide A	Rattus norvegicus	0-25
10651063-1	1999	We have previously reported that atrial natriuretic factor (ANF) increased neuronal norepinephrine (NE) uptake and reduced basal and evoked neuronal NE release.	Norepinephrine	84-98	natriuretic peptide A	Rattus norvegicus	33-58
10570042-3	1999	Recently, we demonstrated that platelet-derived growth factor (PDGF)-beta receptor stimulation, but not various other growth factors, inhibits transcription of alpha1D-, but not alpha1A- or alpha1B-ARs, resulting in reduced norepinephrine-mediated SMC growth.	Norepinephrine	224-238	platelet derived growth factor subunit B	Rattus norvegicus	63-73
10647009-6	1999	Both low- and high-frequency regulation seem to be physiologically important, as mice lacking both alpha2A- and alpha2C-receptor subtypes have elevated plasma noradrenaline concentrations and develop cardiac hypertrophy with decreased left ventricular contractility by four months of age.	Norepinephrine	159-172	adrenergic receptor, alpha 2c	Mus musculus	112-119
11270969-4	1999	Norepinephrine-induced increase of [Ca2+]i was inhibited by the tyrosine kinase inhibitors quercetin and tyrphostin by 23.8% and 21.4%, respectively, but the accumulation of [3H]InsPs induced by norepinephrine was not.	Norepinephrine	0-14	TXK tyrosine kinase	Homo sapiens	64-79
10494451-2	1999	We evaluated if a functional Cys23Ser polymorphism in the 5-HT2C receptor gene, the principal serotonin receptor in the brain, contributes to variation in serotonin, norepinephrine and dopamine activity, as indexed by their major metabolite concentrations in cerebrospinal fluid (CSF).	Norepinephrine	166-180	5-hydroxytryptamine receptor 2C	Homo sapiens	58-64
10494451-10	1999	This finding suggests that 5-HT2C receptors are involved in the regulation of norepinephrine turnover in humans; however, HTR2C Cys23Ser does not appear to contribute to the risk of alcoholism, or its contribution to this complex and heterogenous disorder is too small to be detected by a sample of this size and structure.	Norepinephrine	78-92	5-hydroxytryptamine receptor 2C	Homo sapiens	27-33
10423355-7	1999	Furthermore, since norepinephrine infusion also increased HO-1 transcript and protein levels, the HO-1 system probably was induced in RHF by the increased interstitial norepinephrine levels known to occur in failing myocardium.	Norepinephrine	168-182	heme oxygenase 1	Canis lupus familiaris	98-102
10338466-1	1999	BACKGROUND: Elevated circulating norepinephrine (NE) has been implicated in causing the profound beta-adrenergic receptor (betaAR) downregulation and receptor uncoupling that are characteristic of end-stage human dilated cardiomyopathy, a process mediated in part by increased levels of beta-adrenergic receptor kinase (betaARK1).	Norepinephrine	33-47	adrenergic receptor, beta 1	Mus musculus	123-129
10369486-0	1999	Further characterization of the ORL1 receptor-mediated inhibition of noradrenaline release in the mouse brain in vitro.	Norepinephrine	69-82	opioid receptor-like 1	Mus musculus	32-36
10369486-9	1999	In conclusion, nociceptin inhibits noradrenaline release in the mouse cortex via ORL1 receptors, which interact with presynaptic alpha2-autoreceptors on noradrenergic neurones.	Norepinephrine	35-48	opioid receptor-like 1	Mus musculus	81-85
10233122-5	1999	The Tc/Tsk contribution ratio was relatively lower for thermal comfort (1:1) than for vasomotor changes (3:1; P = 0.008), metabolic heat production (3.6:1; P = 0.001), norepinephrine (1.8:1; P = 0.03), and epinephrine (3:1; P = 0.006) responses.	Norepinephrine	168-182	tsukushi, small leucine rich proteoglycan	Homo sapiens	7-10
10228005-0	1999	Suppression of antigen-specific Th2 cell-dependent IgM and IgG1 production following norepinephrine depletion in vivo.	Norepinephrine	85-99	LOC105243590	Mus musculus	59-63
10399886-11	1999	These results reveal that cholic acid is able to induce hypertension and provide evidence that cholic acid inhibits the transcription of both 11beta-HSD2 and CYP11B2 in vasculature, leading to lower aldosterone and higher corticosterone production in vessels and increased vasoconstrictor responses to norepinephrine.	Norepinephrine	302-316	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	142-153
10399886-11	1999	These results reveal that cholic acid is able to induce hypertension and provide evidence that cholic acid inhibits the transcription of both 11beta-HSD2 and CYP11B2 in vasculature, leading to lower aldosterone and higher corticosterone production in vessels and increased vasoconstrictor responses to norepinephrine.	Norepinephrine	302-316	cytochrome P450, family 11, subfamily b, polypeptide 2	Rattus norvegicus	158-165
9930739-4	1999	GFRP mRNA expression was abundant in serotonin neurons of the dorsal raphe nucleus but was undetectable in dopamine neurons of the midbrain or norepinephrine neurons of the locus coeruleus.	Norepinephrine	143-157	GTP cyclohydrolase I feedback regulator	Rattus norvegicus	0-4
10437163-7	1999	CONCLUSION: Only alpha 1A-adrenoceptors mediate the norepinephrine-induced vasopressor response in perfused rat mesenteric vascular bed.	Norepinephrine	52-66	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	17-25
10634350-7	1999	Medications with dual effects--blocking reuptake of both serotonin and norepinephrine (e.g., clomipramine and venlafaxine XR)--have superior benefits in achieving remission in major depression and GAD.	Norepinephrine	71-85	glutamate decarboxylase 1	Homo sapiens	197-200
10193907-3	1999	In NAT-cells amphetamine stimulated [3H]noradrenaline efflux concentration-dependently when added to the superfusion buffer at 0.01, 0.1 and 1 microM.	Norepinephrine	40-53	bromodomain containing 2	Homo sapiens	3-6
10477081-6	1999	PACAP increased tyrosine hydroxylase and dopamine beta-hydroxylase activities, but slightly lowered phenylethanolamine N-methyltransferase activity, resulting in a preferential rise in norepinephrine over epinephrine.	Norepinephrine	185-199	adenylate cyclase activating polypeptide 1	Bos taurus	0-5
9928183-2	1998	It is hypothesized that increased activity of the locus coeruleus (LC) neurons, the principal norepinephrine (NE)-containing cells in the brain, causes release of galanin (GAL) in the ventral tegmentum (VTA) from LC axon terminals in which GAL is colocalized with NE.	Norepinephrine	94-108	galanin and GMAP prepropeptide	Homo sapiens	163-170
9928183-2	1998	It is hypothesized that increased activity of the locus coeruleus (LC) neurons, the principal norepinephrine (NE)-containing cells in the brain, causes release of galanin (GAL) in the ventral tegmentum (VTA) from LC axon terminals in which GAL is colocalized with NE.	Norepinephrine	94-108	galanin and GMAP prepropeptide	Homo sapiens	172-175
9792725-3	1998	Using Rat1 cells stably transfected with each of the three cloned human alpha1 adrenergic receptor subtypes, norepinephrine strongly stimulated CREB phosphorylation in alpha1A and alpha1B but more weakly in alpha1D-transfected cells.	Norepinephrine	109-123	cAMP responsive element binding protein 1	Homo sapiens	144-148
9792725-3	1998	Using Rat1 cells stably transfected with each of the three cloned human alpha1 adrenergic receptor subtypes, norepinephrine strongly stimulated CREB phosphorylation in alpha1A and alpha1B but more weakly in alpha1D-transfected cells.	Norepinephrine	109-123	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	168-175
9792725-7	1998	In addition, alpha1 adrenergic receptor-induced CREB phosphorylation was not mediated via the mitogen-activated protein kinase pathway because norepinephrine did not stimulate mitogen-activated protein kinase activity in these cells.	Norepinephrine	143-157	cAMP responsive element binding protein 1	Homo sapiens	48-52
9769330-5	1998	The negative inotropic effects of a beta3-adrenoceptor agonist, BRL 37344, and also of norepinephrine in the presence of alpha- and beta1-2-blockade were inhibited both by a nonspecific blocker of NO, methylene blue, and two NO synthase (NOS) inhibitors, L-N-monomethyl-arginine and L-nitroarginine-methyl ester.	Norepinephrine	87-101	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	132-139
9792233-1	1998	We have previously reported that atrial natriuretic factor (ANF) increases neuronal uptake and endogenous content of norepinephrine (NE) and diminishes neuronal release, synthesis and turn-over of NE in rat hypothalamus and adrenal medulla.	Norepinephrine	117-131	natriuretic peptide A	Rattus norvegicus	33-58
9792233-1	1998	We have previously reported that atrial natriuretic factor (ANF) increases neuronal uptake and endogenous content of norepinephrine (NE) and diminishes neuronal release, synthesis and turn-over of NE in rat hypothalamus and adrenal medulla.	Norepinephrine	117-131	natriuretic peptide A	Rattus norvegicus	60-63
9687576-3	1998	In Xenopus laevis oocytes expressing hOCT2, electrogenic transport of norepinephrine, histamine, dopamine, serotonin, and the antiparkinsonian drugs memantine and amantadine was demonstrated by tracer influx, tracer efflux, electrical measurements, or a combination.	Norepinephrine	70-84	POU class 2 homeobox 2	Homo sapiens	37-42
9655843-8	1998	3-Isobutyl-1-methylxanthine in rates of 0.6 to 1.3 mumol/ min attenuated the CNP-induced positive inotropic responses, when it potentiated the positive inotropic response to norepinephrine.	Norepinephrine	174-188	natriuretic peptide C	Canis lupus familiaris	77-80
9565624-4	1998	In HuH-7.MCAT-1 cells, L-arginine uptake was significantly up-regulated by norepinephrine and dexamethasone, and hepatocyte growth factor also increased L-arginine uptake along with cellular DNA synthesis.	Norepinephrine	75-89	MIR7-3 host gene	Homo sapiens	3-8
9605572-5	1998	Adrenomedullin and alpha-CGRP caused a concentration-dependent relaxation in the rat aorta contracted with noradrenaline.	Norepinephrine	107-120	adrenomedullin	Rattus norvegicus	0-14
9523560-7	1998	The effect of IFN-alpha on [3H]noradrenaline uptake was diminished in protein kinase C-down-regulated cells.	Norepinephrine	31-44	interferon alpha-A	Bos taurus	14-23
9507151-6	1998	These results suggest that microsphere embolism-induced changes in noradrenaline release from nerve terminals are due to a failure in the process following phosphorylation of synapsin I.	Norepinephrine	67-80	synapsin I	Rattus norvegicus	175-185
9666280-0	1998	The role of norepinephrine and beta-2-adrenergic receptor stimulation in the modulation of Th1, Th2, and B lymphocyte function.	Norepinephrine	12-26	negative elongation factor complex member C/D	Homo sapiens	91-94
9505862-0	1998	Increased plasma levels of adrenomedullin in patients with hypertrophic cardiomyopathy: its relation to endothelin-I, natriuretic peptides and noradrenaline.	Norepinephrine	143-156	adrenomedullin	Homo sapiens	27-41
9505862-16	1998	Our results indicate that adrenomedullin may play an important role to maintain haemodynamics in patients with hypertrophic cardiomyopathy, and its action may be related to endothelin-1 but independent of atrial natriuretic peptide, brain natriuretic peptide and noradrenaline.	Norepinephrine	263-276	adrenomedullin	Homo sapiens	26-40
9421421-1	1998	c-Fos/c-Jun dimers (activating protein-1 transcription factor) are involved in the modulatory actions of angiotensin II (Ang II) on brain norepinephrine neurons, effects mediated via Ang II type 1 (AT1) receptors.	Norepinephrine	138-152	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
9474095-8	1998	After precontraction with norepinephrine, the maximal relaxation to acetylcholine (endothelium-dependent, receptor-mediated agonist) for control vein grafts was 0%, whereas for VEGF-treated vein grafts it was 25% +/- 9% (p &lt; 0.05 vs control grafts).	Norepinephrine	26-40	vascular endothelial growth factor A	Oryctolagus cuniculus	177-181
9686497-7	1998	Plasma adrenomedullin was correlated strongly with endothelin-1,2, atrial natriuretic peptide, and noradrenaline, and relatively weakly with left ventricular ejection fraction.	Norepinephrine	99-112	adrenomedullin	Homo sapiens	7-21
9769705-13	1998	Both serotonin, acting through 5-HT2C receptors, and norepinephrine, acting through beta 2 and/or beta 3 receptors, reduce food intake.	Norepinephrine	53-67	hemoglobin, beta adult minor chain	Mus musculus	84-104
9405459-8	1997	Since a subpressor dose of Ang II did not increase GRK5 mRNA levels and norepinephrine infusion also increased GRK5 mRNA expression, we conclude that Ang II-induced GRK5 up-regulation in rat aortas may be due to hypertension per se.	Norepinephrine	72-86	G protein-coupled receptor kinase 5	Rattus norvegicus	111-115
9405459-8	1997	Since a subpressor dose of Ang II did not increase GRK5 mRNA levels and norepinephrine infusion also increased GRK5 mRNA expression, we conclude that Ang II-induced GRK5 up-regulation in rat aortas may be due to hypertension per se.	Norepinephrine	72-86	G protein-coupled receptor kinase 5	Rattus norvegicus	111-115
9421306-11	1997	NPY, PYY and PYY(3-36) inhibited [3H]-noradrenaline release from preparations of epididymis (pIC50 values 7.9+/-0.7, 9.6+/-0.8 and 10.0+/-0.9, respectively, all n=6).	Norepinephrine	38-51	pro-neuropeptide Y	Cavia porcellus	0-3
9436100-5	1997	Elevated norepinephrine concentrations during the pretreatment period were associated with the inhibition of oxytocin responses.	Norepinephrine	9-23	oxytocin/neurophysin I prepropeptide	Homo sapiens	109-117
9436100-6	1997	When norepinephrine concentrations during the pretreatment period exceeded 300 pg/ml for Friescens, or were rising and exceeded 700 pg/ml at initiation of the experimental period for Lacaunes, oxytocin release was inhibited.	Norepinephrine	5-19	oxytocin/neurophysin I prepropeptide	Homo sapiens	193-201
9396553-7	1997	Upon induction of acidosis, pHi fell rapidly in the artery precontracted by norepinephrine or high KCl, and the depression of pHi was similar in the two groups.	Norepinephrine	76-90	glucose-6-phosphate isomerase	Oryctolagus cuniculus	28-31
9449068-13	1997	Neurotrophin-3 (NT-3) specifically promotes high affinity uptake of norepinephrine by neural crest cells and is thus thought to play a critical role in the differentiation of sympathetic neuroblasts.	Norepinephrine	68-82	neurotrophin 3	Homo sapiens	0-14
9428617-11	1997	Combination of norepinephrine with pre- and afterload elevation induced the c-fos mRNA signal to appear earlier, to be more pronounced, and to persist for a longer period of time.	Norepinephrine	15-29	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	76-81
9403317-4	1997	Norepinephrine and epinephrine operate through differential recruitment of alpha 2- and beta-AR subtypes on the basis of their relative affinity for the different subtypes (the relative order of affinity is alpha 2 &gt; beta 1 &gt; or = beta 2 &gt; beta 3 for norepinephrine).	Norepinephrine	0-14	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	220-226
9251973-3	1997	Noradrenaline, clonidine (an alpha2-adrenergic receptor agonist), or phenylephrine (an alpha1-adrenergic receptor agonist) injected into the MnPO of sham-lesioned rats reduced water ingestion induced by ANG II injected into the same area.	Norepinephrine	0-13	angiogenin	Rattus norvegicus	203-206
9432289-4	1997	The inhibition of MAO-A cause the rise of norepinephrine, dopamine and serotonin in the synaptic cleft, of MAO-B only of dopamine.	Norepinephrine	42-56	monoamine oxidase B	Homo sapiens	107-112
9166734-6	1997	The glial norepinephrine response was blocked by phentolamine but not by the removal of external Ca2+, indicating a direct activation of alpha1-adrenergic receptors that mediated release of Ca2+ from intracellular stores.	Norepinephrine	10-24	carbonic anhydrase 2	Homo sapiens	190-193
9154329-13	1997	In cross-loading experiments, 5 mM Na(+)- or 0 Cl(-)-induced efflux was much lower from [3H]-noradrenaline-loaded DAT, than NAT cells and was sensitive to mazindol, but not to desipramine.	Norepinephrine	93-106	solute carrier family 6 member 3	Homo sapiens	114-117
9146881-0	1997	Simulatory effect of porcine insulin on noradrenaline secretion in guinea-pig ileum myenteric nerve terminals.	Norepinephrine	40-53	insulin	Cavia porcellus	29-36
9146881-2	1997	The effect of insulin on the release of noradrenaline (NA) from nerve terminals was investigated in isolated ileal synaptosomes of guinea-pig.	Norepinephrine	40-53	insulin	Cavia porcellus	14-21
9137239-13	1997	CONCLUSIONS: During sympathetic nerve stimulation, the vasoconstrictive actions of NPY are masked by norepinephrine under intact alpha-adrenoceptor conditions, manifest during alpha-blockade and modulated by KATP channel activity.	Norepinephrine	101-115	neuropeptide Y	Canis lupus familiaris	83-86
9044380-8	1997	The results, based on these pharmacological profiles, suggest the possible involvement of alpha 3 and beta 2 nicotinic acetylcholine receptor subunits in the control of [3H]noradrenaline release from hippocampal slices.	Norepinephrine	173-186	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	109-141
9057895-6	1997	Norepinephrine (NE)-induced pressor response was inhibited by the ChE inhibitors with the same order and magnitude as the depressor response.	Norepinephrine	0-14	cholinesterase	Oryctolagus cuniculus	66-69
9076657-3	1997	The naloxone-induced rise in norepinephrine release was attenuated by concomitant administration of a protein kinase inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine hydrochloride (H-7) or an NMDA receptor antagonist, (+)-5-methyl-10, 11-dihydro-5H-dibenzo[a,d]-cyclohepten-5, 10-imine hydrogen maleate (dizocilpine, MK-801) with morphine.	Norepinephrine	29-43	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	102-116
9812844-2	1997	10(-6) mol/L ADM could also ameliorate alteration of the hemorheology induced by 10(-5) mol/L norepinephrine (NE) or 10(-7) mol/L endothelin (ET).	Norepinephrine	94-108	adrenomedullin	Rattus norvegicus	13-16
9038983-2	1997	Contractile response to five concentrations (10(-8)-10(-7) M) of the beta 1-AR agonist norepinephrine (NE) plus prazosin (10(-6) M) was measured after a 60-s rest, i.e., rested-state contraction (RSC), and during steady-state contraction (SSC) stimulation at 0.5 Hz (23 degrees C).	Norepinephrine	87-101	adrenergic receptor, beta 1	Mus musculus	69-78
9437706-1	1997	We have previously reported that atrial natriuretic factor (ANF) modulates adrenomedullar norepinephrine (NE) metabolism.	Norepinephrine	90-104	natriuretic peptide A	Rattus norvegicus	33-58
9437706-1	1997	We have previously reported that atrial natriuretic factor (ANF) modulates adrenomedullar norepinephrine (NE) metabolism.	Norepinephrine	90-104	natriuretic peptide A	Rattus norvegicus	60-63
8952593-8	1996	Atrial natriuretic factor, however, increased at 7 and 14 days of servo-controlled norepinephrine, and plasma renin activity increased on day 14 of norepinephrine infusion.	Norepinephrine	148-162	renin	Canis lupus familiaris	110-115
8939965-0	1996	Calcium/calmodulin-dependent protein kinase IIalpha mediates activation of mitogen-activated protein kinase and cytosolic phospholipase A2 in norepinephrine-induced arachidonic acid release in rabbit aortic smooth muscle cells.	Norepinephrine	142-156	cytosolic phospholipase A2	Oryctolagus cuniculus	112-138
8903325-0	1996	Atrial natriuretic peptide regulation of noradrenaline release in the anterior hypothalamic area of spontaneously hypertensive rats.	Norepinephrine	41-54	natriuretic peptide A	Rattus norvegicus	0-26
8903325-2	1996	Atrial natriuretic peptide (ANP) can inhibit the release of noradrenaline, and ANP concentration is elevated in the AHA of SHR.	Norepinephrine	60-73	natriuretic peptide A	Rattus norvegicus	0-26
8903325-2	1996	Atrial natriuretic peptide (ANP) can inhibit the release of noradrenaline, and ANP concentration is elevated in the AHA of SHR.	Norepinephrine	60-73	natriuretic peptide A	Rattus norvegicus	28-31
8903325-3	1996	The present study tests the hypothesis that in SHR, local ANP inhibits noradrenaline release from nerve terminals in AHA.	Norepinephrine	71-84	natriuretic peptide A	Rattus norvegicus	58-61
8903325-5	1996	In SHR on the basal diet, microperfusion of exogenous ANP into the AHA elicited a dose-related decrease in the concentration of the major noradrenaline metabolite 3-methoxy-4-hydroxy-phenylglycol (MOPEG) in the AHA; this effect was attenuated in the other two groups.	Norepinephrine	138-151	natriuretic peptide A	Rattus norvegicus	54-57
8898084-2	1996	In voltage-clamp experiments with rOCT1-expressing Xenopus oocytes, superfusion with dopamine, serotonin, noradrenaline, histamine and the permanent cation acetylcholine induced saturable inwardly directed currents with apparent Km values ranging from 20 to 100 microM.	Norepinephrine	106-119	solute carrier family 22 member 1	Rattus norvegicus	34-39
8911658-4	1996	In ovariectomised oil-treated rats, a third ventricular infusion of noradrenaline (45 micrograms) resulted in a significant (P &lt; 0.05) increase in the numbers of Fos-immunoreactive cell nuclei throughout the preoptic area, compared to vehicle controls.	Norepinephrine	68-81	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	165-168
8911658-9	1996	These results show that noradrenaline-induced Fos expression in the preoptic area is dependent on estrogen status and suggest that the estrogenic regulation of reproductive functions may thus involve altered responses to noradrenaline in sub-populations of preoptic neurones.	Norepinephrine	24-37	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	46-49
8896816-10	1996	Concomitant with the changes nNOS gene expression in central sites, the plasma concentration of norepinephrine was significantly elevated in rats with heart failure compared to sham-operated control rats.	Norepinephrine	96-110	nitric oxide synthase 1	Rattus norvegicus	29-33
8902882-5	1996	Norepinephrine and epinephrine also suppressed IL-12 production in a dose-dependent fashion and at physiological concentrations; both catecholamines, however, dose-dependently increased the production of IL-10.	Norepinephrine	0-14	interleukin 10	Homo sapiens	204-209
8759029-5	1996	The marked susceptibility to down-regulation displayed by PKC-alpha and -delta was accompanied by an enhanced secretory response to norepinephrine as compared with control cells.	Norepinephrine	132-146	protein kinase C, alpha	Rattus norvegicus	58-78
8759029-6	1996	Further, the selective PKC inhibitors Ro 31-8220 and CGP 41,251 also produced a concentration-dependent enhancement of norepinephrine-induced amylase secretion.	Norepinephrine	119-133	protein kinase C, alpha	Rattus norvegicus	23-26
8876997-0	1996	Poly(ADP-ribose) polymerase inhibitors protect against MPTP-induced depletions of striatal dopamine and cortical noradrenaline in C57B1/6 mice.	Norepinephrine	113-126	poly (ADP-ribose) polymerase family, member 1	Mus musculus	0-27
8864538-0	1996	Inhibition of exocytotic noradrenaline release by presynaptic cannabinoid CB1 receptors on peripheral sympathetic nerves.	Norepinephrine	25-38	cannabinoid receptor 1	Rattus norvegicus	74-77
8878061-9	1996	It is concluded that ethanol predominantly inhibits NMDA receptors containing a high proportion of the NMDAR2B subunit (as reflected by high sensitivity to ifenprodil), i.e. the NMDA receptors involved in stimulation of noradrenaline, 5-hydroxytryptamine and GABA release.	Norepinephrine	220-233	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	103-110
8897649-4	1996	Colocalization studies of tyrosine hydroxylase (TH) and Fos protein revealed that in the brainstem, 73 to 85% of noradrenaline-containing cells expressed Fos immunoreactivity.	Norepinephrine	113-126	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	56-59
8897649-4	1996	Colocalization studies of tyrosine hydroxylase (TH) and Fos protein revealed that in the brainstem, 73 to 85% of noradrenaline-containing cells expressed Fos immunoreactivity.	Norepinephrine	113-126	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	154-157
8670175-7	1996	In addition, experiments in vitro indicate that low millimolar amounts of either adrenaline (IC50 5.2 mM) or noradrenaline (IC50 2.4 mM) can significantly impair the proteolytic activity of recombinant murine prohormone convertase 1 when assayed with synthetic fluorogenic and/or peptidyl substrates.	Norepinephrine	109-122	proprotein convertase subtilisin/kexin type 1	Mus musculus	209-232
8661508-2	1996	CATH.a cells express several differentiated neuronal characteristics including medium and light chain neurofilament proteins, synaptophysin, tyrosine hydroxylase, and dopamine beta-hydroxylase; they synthesize dopamine and norepinephrine.	Norepinephrine	223-237	cathepsin H	Mus musculus	0-4
8631897-2	1996	Induction of the promoter by transforming growth factor beta or norepinephrine requires serum response factor (SRF) and TEF-1; expression is inhibited by YY1.	Norepinephrine	64-78	serum response factor	Homo sapiens	88-109
8631897-2	1996	Induction of the promoter by transforming growth factor beta or norepinephrine requires serum response factor (SRF) and TEF-1; expression is inhibited by YY1.	Norepinephrine	64-78	serum response factor	Homo sapiens	111-114
8627519-10	1996	Thus, only antidepressant drugs that affect norepinephrine uptake (i.e., imipramine, desipramine and nisoxetine) antagonized swim stress-induced Fos-LI.	Norepinephrine	44-58	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	145-148
8792338-7	1996	Overall, a 30-fold range of GTP cyclohydrolase I mRNA expression was observed, with the transcript being significantly more abundant in serotonin than in dopamine or norepinephrine/epinephrine neurons.	Norepinephrine	166-180	GTP cyclohydrolase 1	Rattus norvegicus	28-48
8792338-10	1996	Norepinephrine neurons of the locus coeruleus (A6) and subcoeruleus (A6v) exhibited significantly higher levels of GTP cyclohydrolase I mRNA than did neurons in other norepinephrine (A1 and A2) or epinephrine (C1 and C2) cell groups.	Norepinephrine	0-14	GTP cyclohydrolase 1	Rattus norvegicus	115-135
8635209-1	1996	We have previously shown that extracellular ATP, like norepinephrine (NE) and many other hypertrophy-inducing agents, increases expression of the immediate-early genes c-fos and junB in cultured neonatal cardiac myocytes but that the intracellular signaling pathways activated by ATP and responsible for these changes differ from those stimulated by NE.	Norepinephrine	54-68	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	168-173
8636125-3	1996	Rab3A and Rab3B both targeted to norepinephrine (NE)-containing large dense core vesicles (LDCVs) when stably expressed in PC12 cells, as determined by immunofluorescence and membrane fractionation.	Norepinephrine	33-47	RAB3B, member RAS oncogene family	Rattus norvegicus	10-15
8846821-14	1996	Tyr-W-MIF-1 is mediated through spinal mu2-receptors, and is modulated by norepinephrine and alpha 2-adrenoceptors.	Norepinephrine	74-88	predicted gene 4924	Mus musculus	6-11
8648514-3	1996	A 0.1 ml bolus injection of 10(-5) M human adrenomedullin suppressed the pressor response of the canine tibia preparation to an infusion of norepinephrine by 43-52% for a duration of 100 minutes.	Norepinephrine	140-154	adrenomedullin	Homo sapiens	43-57
8648514-4	1996	An injection of 10(-6) adrenomedullin suppressed the pressor response to an infusion of norepinephrine by 22-23% for a duration of 40 minutes.	Norepinephrine	88-102	adrenomedullin	Homo sapiens	23-37
8692281-0	1996	Inhibition of noradrenaline release via presynaptic 5-HT1D alpha receptors in human atrium.	Norepinephrine	14-27	5-hydroxytryptamine receptor 1D	Homo sapiens	52-64
8788483-10	1996	In strips of atrial appendages, 5-HT receptor agonists (e.g. 5-HT, 5-CT and sumatriptan) inhibited noradrenaline release at potencies which are correlated with their ki values at 5-HT1D alpha and 5-HT1D beta receptors.	Norepinephrine	99-112	5-hydroxytryptamine receptor 1D	Homo sapiens	179-191
8722501-3	1996	In human and guinea-pig isolated arteries alpha-trinositol potently (10 nM to 1 microM extracellular concentration) suppressed the constriction evoked by neuropeptide Y alone, the potentiation by neuropeptide Y of noradrenaline-evoked constriction, and the neuropeptide Y-induced inhibition of relaxation.	Norepinephrine	214-227	pro-neuropeptide Y	Cavia porcellus	196-210
8722501-3	1996	In human and guinea-pig isolated arteries alpha-trinositol potently (10 nM to 1 microM extracellular concentration) suppressed the constriction evoked by neuropeptide Y alone, the potentiation by neuropeptide Y of noradrenaline-evoked constriction, and the neuropeptide Y-induced inhibition of relaxation.	Norepinephrine	214-227	pro-neuropeptide Y	Cavia porcellus	196-210
8848120-7	1996	When incubating the organotypic hippocampal cultures with different concentrations of noradrenaline, nerve growth factor and brain-derived neurotrophic factor messenger RNAs but not neurotrophin-3 messenger RNA were significantly reduced in the dentate gyrus.	Norepinephrine	86-99	brain-derived neurotrophic factor	Rattus norvegicus	125-158
8848120-8	1996	We conclude that nerve growth factor and brain-derived neurotrophic factor but not neurotrophin-3 expression are inhibited by noradrenaline, arising from the locus coeruleus.	Norepinephrine	126-139	brain-derived neurotrophic factor	Rattus norvegicus	41-74
8548058-3	1995	Human GAL administration significantly reduced both the release of basal norepinephrine and the response to insulin-induced hypoglycemia, whereas it attenuated the epinephrine response by 26%, with the hGAL-induced decrease in epinephrine release failing to achieve statistical significance.	Norepinephrine	73-87	galanin and GMAP prepropeptide	Homo sapiens	6-9
8548058-3	1995	Human GAL administration significantly reduced both the release of basal norepinephrine and the response to insulin-induced hypoglycemia, whereas it attenuated the epinephrine response by 26%, with the hGAL-induced decrease in epinephrine release failing to achieve statistical significance.	Norepinephrine	73-87	galanin and GMAP prepropeptide	Homo sapiens	202-206
8548058-5	1995	We conclude that GAL receptor stimulation exerts an inhibitory effect on basal and insulin-induced hypoglycemia-stimulated release of norepinephrine.	Norepinephrine	134-148	galanin and GMAP prepropeptide	Homo sapiens	17-20
8565052-1	1995	In the present study we investigated whether norepinephrine, which stimulates melatonin biosynthesis in the mammalian pineal organ, causes phosphorylation of the cyclic AMP responsive element binding protein (CREB) in rat pinealocytes.	Norepinephrine	45-59	cAMP responsive element binding protein 1	Homo sapiens	162-207
8565052-1	1995	In the present study we investigated whether norepinephrine, which stimulates melatonin biosynthesis in the mammalian pineal organ, causes phosphorylation of the cyclic AMP responsive element binding protein (CREB) in rat pinealocytes.	Norepinephrine	45-59	cAMP responsive element binding protein 1	Homo sapiens	209-213
7562554-1	1995	In previous investigations, we have demonstrated that cholinesterase inhibitors such as physostigmine (PHY) and heptylphysostigmine (HEP) elicit a significant and simultaneous increase in acetylcholine (ACh) and norepinephrine (NE) levels in the rat cortex.	Norepinephrine	212-226	butyrylcholinesterase	Rattus norvegicus	54-68
8748977-0	1995	Norepinephrine induces expression of c-fos mRNA through the alpha-adrenoceptor in rat aortic rings.	Norepinephrine	0-14	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	37-42
8748977-1	1995	We examined whether norepinephrine at pharmacologically relevant doses induces increased expression of c-fos mRNA in rat aortic rings.	Norepinephrine	20-34	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	103-108
8748977-2	1995	c-fos mRNA was expressed at norepinephrine concentrations known to cause minimum and maximum contraction of rat aorta in vitro.	Norepinephrine	28-42	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
8748977-3	1995	At the concentration known to cause maximum contraction, norepinephrine produced a marked and sustained increase of c-fos mRNA expression.	Norepinephrine	57-71	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	116-121
8748977-5	1995	A prazosin inhibition curve showed that 1 nmol/L prazosin inhibited 10 micromol/L norepinephrine induced c-fos expression by 40%.	Norepinephrine	82-96	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	105-110
8748977-6	1995	At the pharmacologic dose known to cause maximum contraction, norepinephrine induces c-fos mRNA expression through the alpha-adrenoceptor in rat aortic rings.	Norepinephrine	62-76	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	85-90
7657838-0	1995	Proadrenomedullin NH(2)-terminal 20 peptide, a new product of the adrenomedullin gene, inhibits norepinephrine overflow from nerve endings.	Norepinephrine	96-110	adrenomedullin	Rattus norvegicus	3-17
7657838-5	1995	In contrast, vasoconstrictive response of mesenteric arteries to exogenous norepinephrine was significantly attenuated by 10 pmol/ml of adrenomedullin but not by the same dose of PAMP.	Norepinephrine	75-89	adrenomedullin	Rattus norvegicus	136-150
7666200-10	1995	In the CNS, dopamine, norepinephrine, epinephrine, 5-HT, and histamine cell groups all express VMAT2.	Norepinephrine	22-36	solute carrier family 18 member A2	Rattus norvegicus	95-100
8545048-0	1995	Atrial natriuretic factor enhances norepinephrine uptake in circumventricular organs, locus coeruleus and nucleus tractus solitarii of the rat.	Norepinephrine	35-49	natriuretic peptide A	Rattus norvegicus	0-25
7498270-0	1995	Platelet-activating factor-induced loss of vascular responsiveness to noradrenaline in pithed rats: involvement of nitric oxide.	Norepinephrine	70-83	PCNA clamp associated factor	Rattus norvegicus	0-26
7611494-3	1995	Des-Asp1-angiotensin I, angiotensin I, II, and III produced similar increases in perfusion pressure and were approximately 300-fold more potent than (p-amino-Phe6)-angiotensin II, 100-fold more potent than angiotensin IV, 30-fold more potent than norepinephrine, and 10-fold more potent than U-46619.	Norepinephrine	247-261	beta-secretase 2	Homo sapiens	4-8
7737731-3	1995	During the first 60 minutes of norepinephrine infusion in control dogs, mean arterial pressure increased 9 +/- 4 mm Hg in association with a twofold to threefold rise in plasma renin activity.	Norepinephrine	31-45	renin	Canis lupus familiaris	177-182
7612155-4	1995	In addition, c-fos induction in response to acute restraint stress was down-regulated by chronic, but not acute, administration of tranylcypromine or imipramine, two drugs that nonselectively increase synaptic levels of norepinephrine and serotonin by inhibition of monoamine oxidase or neurotransmitter reuptake, respectively.	Norepinephrine	220-234	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	13-18
7612155-5	1995	Moreover, chronic administration of desipramine or sertraline, selective re-uptake inhibitors of norepinephrine, or serotonin, respectively, also significantly down-regulated the induction of c-fos mRNA in response to restraint stress.	Norepinephrine	97-111	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	192-197
7727409-2	1995	The resonance Raman spectra of hTH1 complexed with dopamine, noradrenaline, tyramine, and catechol have been studied and compared to those obtained for TH isolated from bovine adrenal glands or rat phaeochromocytoma tissue.	Norepinephrine	61-74	negative elongation factor complex member C/D	Homo sapiens	31-35
7601207-5	1995	Neuropeptide Y, but not peptide YY or neuropeptide Y analogues, evoked the release of noradrenaline.	Norepinephrine	86-99	pro-neuropeptide Y	Cavia porcellus	0-14
7781701-2	1995	We investigated the effect of the cholinesterase inhibitor, MDL 73,745 (2,2,2-trifluoro-1-(3-trimethylsilylphenyl)ethanone), on the extracellular levels of acetylcholine, norepinephrine, dopamine and 5-hydroxytryptamine in the cerebral cortex of the rat by high-performance liquid chromatography coupled with electrochemical detection.	Norepinephrine	171-185	butyrylcholinesterase	Rattus norvegicus	34-48
7887963-2	1995	In aortic rings precontracted with 0.3 microM norepinephrine PTHrP(1-34) caused a dose-dependent relaxation with the maximal response of 33% being observed at 10(-6) M. PTHrP was nearly equipotent to PTH or CGRP in the vasodilatory action.	Norepinephrine	46-60	parathyroid hormone-like hormone	Rattus norvegicus	61-66
7887963-2	1995	In aortic rings precontracted with 0.3 microM norepinephrine PTHrP(1-34) caused a dose-dependent relaxation with the maximal response of 33% being observed at 10(-6) M. PTHrP was nearly equipotent to PTH or CGRP in the vasodilatory action.	Norepinephrine	46-60	parathyroid hormone-like hormone	Rattus norvegicus	169-174
7891145-1	1995	We investigated whether interleukin-1 (IL-1) activity in the rat hypothalamus was increased by immobilization stress (IS), and whether pretreatment with an interleukin-1 receptor antagonist (IL-1Ra) is capable of inhibiting IS-induced elevations of hypothalamic norepinephrine (NE), dopamine (DA), and serotonin (5-HT) and the levels of their metabolites as well as of plasma adrenocorticotropic hormone (ACTH).	Norepinephrine	262-276	interleukin 1 receptor antagonist	Rattus norvegicus	156-189
7891145-1	1995	We investigated whether interleukin-1 (IL-1) activity in the rat hypothalamus was increased by immobilization stress (IS), and whether pretreatment with an interleukin-1 receptor antagonist (IL-1Ra) is capable of inhibiting IS-induced elevations of hypothalamic norepinephrine (NE), dopamine (DA), and serotonin (5-HT) and the levels of their metabolites as well as of plasma adrenocorticotropic hormone (ACTH).	Norepinephrine	262-276	interleukin 1 receptor antagonist	Rattus norvegicus	191-197
7840338-4	1995	The catecholamine output from the adrenal glands in the sham group significantly increased (P &lt; 0.05), reaching a maximum level 45 min after insulin injection from a control value for epinephrine of 86.35 +/- 26.65 ng/min and for norepinephrine of 32.14 +/- 11.68 ng/min to 659.03 +/- 269.39 and 181.21 +/- 63.03 ng/min, respectively.	Norepinephrine	233-247	insulin	Canis lupus familiaris	144-151
7628838-1	1995	Catecholamines (adrenaline and noradrenaline) stimulate adipocyte lipolysis via three beta-adrenoceptor subtypes beta 1, beta 2 and beta 3.	Norepinephrine	31-44	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	113-119
8839228-2	1995	In norepinephrine-contracted arteries, ITF 296, NTG, and ISDN elicited maximal and concentration-dependent vasodilation with pD2 values of 7.07, 7.95, and 7.2, respectively.	Norepinephrine	3-17	trefoil factor 3	Rattus norvegicus	39-42
8839228-5	1995	A time-dependent increase in cGMP content and a positive correlation between cGMP and vasodilation were observed in norepinephrine-contracted arteries after exposure to a single submaximal concentration of ITF 296 (1 microM).	Norepinephrine	116-130	trefoil factor 3	Rattus norvegicus	206-209
7760370-1	1995	We have studied the effects of pressure and volume overload as well as of norepinephrine (NE) alone and in combination on the expression of the proto-oncogenes c-fos and c-myc in isolated perfused working rat hearts.	Norepinephrine	74-88	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	160-165
7721026-7	1994	MAO-B inhibitors can selectively and dramatically increase the level of beta-phenylethylamine, which has been shown to potentiate dopamine and noradrenaline function in the central nervous system.	Norepinephrine	143-156	monoamine oxidase B	Homo sapiens	0-5
7962564-6	1994	Moreover, adrenomedullin showed intimate correlations with norepinephrine, atrial natriuretic peptide, and cAMP in plasma (r = 0.625, P &lt; 0.001; r = 0.656, P &lt; 0.001; and r = 0.462, P &lt; 0.001; respectively).	Norepinephrine	59-73	adrenomedullin	Homo sapiens	10-24
8013086-2	1994	Pretreatment with TGF-beta 1 potentiated norepinephrine (NE)-induced and stretch-induced (+10% and +20% elongation, for 30 minutes) c-fos mRNA expression by 2.2-fold, whereas TGF-beta 1 alone did not induce c-fos mRNA expression in Northern blot analysis.	Norepinephrine	41-55	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	132-137
7963511-11	1994	Moreover, the change in systolic blood pressure (SBP) between weeks 0 and 2 was negatively correlated with the change in urinary kallikrein activity between weeks 0 and 2, the change in total dopamine between weeks 0 and 2 was negatively correlated with the change in diastolic blood pressure in the same period, and the change in SBP between weeks 0 and 10 was positively correlated with the change in total noradrenaline in the same period in the exercise group.	Norepinephrine	409-422	kallikrein related peptidase 4	Homo sapiens	129-139
8024626-4	1994	Norepinephrine (10(-9) mol/l) slightly, but not significantly, decreased the CRF-stimulated ANP release and did not change the basal ANP output.	Norepinephrine	0-14	natriuretic peptide A	Rattus norvegicus	92-95
8063046-4	1994	The noradrenaline resistance could be ascribed to a 10-fold decrease in lipolytic beta 2-adrenoceptor sensitivity (p &lt; 0.01).	Norepinephrine	4-17	adrenoceptor beta 2	Homo sapiens	82-101
7910371-10	1994	Overall, the rank order of efficacy of these agonists to elicit stimulation of adenylyl cyclase activity by alpha 2C10 was epinephrine = norepinephrine = UK-14304 &gt; BHT-933 &gt; BHT-920 &gt; oxymetazoline.	Norepinephrine	137-151	adrenoceptor alpha 2A	Homo sapiens	108-118
8028022-3	1994	Activation of alpha 1-adrenergic receptors by norepinephrine (in the presence of propranolol) increased the rate of ANP secretion approximately two-fold (EC50 = 0.32 microM).	Norepinephrine	46-60	natriuretic peptide A	Rattus norvegicus	116-119
8173946-16	1994	This suggests that NPY acts by decreasing noradrenaline release.	Norepinephrine	42-55	neuropeptide Y	Canis lupus familiaris	19-22
8173946-18	1994	NPY increases acid secretion by decreasing tonic central adrenergic inhibition of acid by decreasing release of noradrenaline at a pre-synaptic level.	Norepinephrine	112-125	neuropeptide Y	Canis lupus familiaris	0-3
7907526-2	1994	Previous work has shown that direct microinjections of the alpha 2 agonist clonidine and of norepinephrine into the mPRF suppress the REM phase of sleep.	Norepinephrine	92-106	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	116-120
8294418-0	1994	Phorbol esters and norepinephrine destabilize alpha 1B-adrenergic receptor mRNA in vascular smooth muscle cells.	Norepinephrine	19-33	alpha-1B adrenergic receptor	Oryctolagus cuniculus	46-74
8294418-1	1994	The mechanism by which norepinephrine (NE) down-regulates alpha 1B-adrenergic receptor (alpha-AR) mRNA was studied in rabbit aortic smooth muscle cells.	Norepinephrine	23-37	alpha-1B adrenergic receptor	Oryctolagus cuniculus	58-86
8294418-1	1994	The mechanism by which norepinephrine (NE) down-regulates alpha 1B-adrenergic receptor (alpha-AR) mRNA was studied in rabbit aortic smooth muscle cells.	Norepinephrine	23-37	alpha-1B adrenergic receptor	Oryctolagus cuniculus	88-96
8201228-6	1994	Atrial natriuretic peptide-induced changes in plasma norepinephrine concentrations were significantly higher in normal than in cirrhotic rats (1827 +/- 834 vs. 59 +/- 46 pg/ml, mean +/- S.E., respectively).	Norepinephrine	53-67	natriuretic peptide A	Rattus norvegicus	0-26
7908124-3	1994	While CH-38083 and idazoxan, non-subtype selective alpha 2-adrenoceptor antagonists and BRL44408, a selective alpha 2A-adrenoceptor antagonist as well as WB4101 potentiated the lipolytic effect of noradrenaline, ARC-239, the selective alpha 2B-adrenoceptor antagonist failed to affect it.	Norepinephrine	197-210	adrenoceptor alpha 2A	Homo sapiens	110-131
8287409-7	1993	When noradrenaline was infused, c-fos mRNA was increased fivefold after 30, threefold after 60, and 3.8-fold after 90 min.	Norepinephrine	5-18	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	32-37
8114953-3	1993	beta 1-adrenoceptors were activated by (-)-noradrenaline during beta 2-adrenoceptor blockade with 50 nmol/l ICI 118551.	Norepinephrine	39-56	adrenoceptor beta 2	Homo sapiens	64-83
8114954-3	1993	Neuropeptide Y (NPY), its C-terminal fragment NPY (16-36) and peptide YY (PYY), at a concentration of 0.1 mumol/l all, potentiated the effect of noradrenaline, while [Leu31, Pro34]NPY (0.1 mumol/l) was inactive.	Norepinephrine	145-158	peptide YY	Rattus norvegicus	62-72
8114954-3	1993	Neuropeptide Y (NPY), its C-terminal fragment NPY (16-36) and peptide YY (PYY), at a concentration of 0.1 mumol/l all, potentiated the effect of noradrenaline, while [Leu31, Pro34]NPY (0.1 mumol/l) was inactive.	Norepinephrine	145-158	peptide YY	Rattus norvegicus	74-77
7904926-0	1993	Atrial natriuretic factor inhibits noradrenaline release in the presence of angiotensin II and III in the rat hypothalamus.	Norepinephrine	35-48	natriuretic peptide A	Rattus norvegicus	0-25
8263948-0	1993	Expression of c-fos and related genes in the rat heart in response to norepinephrine.	Norepinephrine	70-84	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-19
8263948-1	1993	We have investigated the cellular and regional localization of Fos-like immunoreactivity (FLI) in the rat heart in response to the hypertrophic hormone norepinephrine (NE).	Norepinephrine	152-166	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	63-66
8292267-1	1993	The sensitivity of rat anococcygeus muscle to noradrenaline (NA) was reduced following carbon disulphide (CS2) pretreatment.	Norepinephrine	46-59	calsyntenin 2	Rattus norvegicus	106-109
8232276-2	1993	In the present work, we studied the effect of AdoMet on norepinephrine (NE)-stimulated inositol phosphate production in 3H-inositol-labelled crude synaptosomal suspensions of rat brain.	Norepinephrine	56-70	methionine adenosyltransferase 1A	Rattus norvegicus	46-52
7686534-0	1993	Potentiation of norepinephrine-induced contractions by endothelin-1 in the rabbit aorta.	Norepinephrine	16-30	endothelin-1	Oryctolagus cuniculus	55-67
7686534-1	1993	Subthreshold concentrations of endothelin-1 potentiated the norepinephrine-induced contraction in isometrically mounted rings of the rabbit aorta.	Norepinephrine	60-74	endothelin-1	Oryctolagus cuniculus	31-43
7686534-2	1993	Pretreatment with endothelin-1 (0.1 nM) for 10 minutes increased the sensitivity of the aortic rings to norepinephrine without affecting the maximal contraction.	Norepinephrine	104-118	endothelin-1	Oryctolagus cuniculus	18-30
7686534-7	1993	We conclude that endothelin-1 potentiation of the norepinephrine-induced contraction occurs in the absence of changes in stimulated Ca2+ entry and is endothelium independent.	Norepinephrine	50-64	endothelin-1	Oryctolagus cuniculus	17-29
8343229-0	1993	Effects of neurotensin on norepinephrine release in blood vessels of spontaneously hypertensive rats.	Norepinephrine	26-40	neurotensin	Rattus norvegicus	11-22
8343229-3	1993	In studies with male standard Wistar rats, endogenous norepinephrine release during periarterial nerve stimulation was inhibited by neurotensin in a dose-dependent manner.	Norepinephrine	54-68	neurotensin	Rattus norvegicus	132-143
8343229-7	1993	These results show that neurotensin could have a modulatory effect on noradrenergic activity and cause a decrease in stimulation-evoked norepinephrine release from vascular adrenergic neurons.	Norepinephrine	136-150	neurotensin	Rattus norvegicus	24-35
8343229-8	1993	The lesser reduction of pressor responses and norepinephrine release by neurotensin in SHR might suggest an insufficient regulation of vascular adrenergic transmission by the peptide hormone in hypertension.	Norepinephrine	46-60	neurotensin	Rattus norvegicus	72-83
8514914-0	1993	Noradrenaline in the brain of the South African clawed frog Xenopus laevis: a study with antibodies against noradrenaline and dopamine-beta-hydroxylase.	Norepinephrine	0-13	dopamine beta-hydroxylase (dopamine beta-monooxygenase) L homeolog	Xenopus laevis	126-151
8402382-0	1993	Influence of atrial natriuretic factor on uptake, intracellular distribution, and release of norepinephrine in rat adrenal medulla.	Norepinephrine	93-107	natriuretic peptide A	Rattus norvegicus	13-38
8402382-3	1993	The aim of the present work was to investigate atrial natriuretic factor effects on the uptake, intracellular distribution, and release of norepinephrine in the rat adrenal medulla.	Norepinephrine	139-153	natriuretic peptide A	Rattus norvegicus	47-72
8402382-4	1993	Results showed that 100 nM atrial natriuretic factor induced a rapid increase of norepinephrine uptake during the first minute of the incubation period.	Norepinephrine	81-95	natriuretic peptide A	Rattus norvegicus	27-52
8402382-7	1993	Atrial natriuretic factor modified the intracellular distribution of the amine store: the granular fraction of norepinephrine increased, while the cytosolic fraction decreased.	Norepinephrine	111-125	natriuretic peptide A	Rattus norvegicus	0-25
8402382-9	1993	Furthermore, atrial natriuretic factor (10 nM) also reduced high potassium solution evoked secretion of norepinephrine.	Norepinephrine	104-118	natriuretic peptide A	Rattus norvegicus	13-38
19912907-10	1993	AVP had significant inhibitory effects on noradrenaline-provoked melatonin secretion in vitro.	Norepinephrine	42-55	arginine vasopressin	Bos taurus	0-3
1281495-11	1992	However, norepinephrine produced a marked elevation of BDNF mRNA in astrocytes, an effect that was further enhanced by glutamate receptor agonists.	Norepinephrine	9-23	brain-derived neurotrophic factor	Rattus norvegicus	55-59
1362158-8	1992	As TFMPP exhibits a close similarity to 5-HT in these experiments, the 5-HT receptor subtype being activated to induce noradrenaline release may either be a 5-HT1C or a 5-HT1S subtype.	Norepinephrine	119-132	5-hydroxytryptamine receptor 2C	Rattus norvegicus	157-163
1472974-7	1992	NPY and the Y1-selective agonist, NPY[Leu31,Pro34], potentiated the constrictor responses to U46619 in both arterioles and responses to noradrenaline in the guinea-pig arterioles.	Norepinephrine	136-149	pro-neuropeptide Y	Cavia porcellus	0-3
1472974-7	1992	NPY and the Y1-selective agonist, NPY[Leu31,Pro34], potentiated the constrictor responses to U46619 in both arterioles and responses to noradrenaline in the guinea-pig arterioles.	Norepinephrine	136-149	pro-neuropeptide Y	Cavia porcellus	34-37
1415729-0	1992	ANF inhibits norepinephrine-stimulated fluid absorption in rat proximal straight tubules.	Norepinephrine	13-27	natriuretic peptide A	Rattus norvegicus	0-3
1438987-0	1992	Effects of atrial natriuretic factor on norepinephrine release in the rat hypothalamus.	Norepinephrine	40-54	natriuretic peptide A	Rattus norvegicus	11-36
1438987-1	1992	The effects of atrial natriuretic factor on the mechanisms involved in norepinephrine release were studied "in vitro" in slices of Wistar rat hypothalamus.	Norepinephrine	71-85	natriuretic peptide A	Rattus norvegicus	15-40
1356432-6	1992	These studies indicate that, in addition to the dopamine system, the norepinephrine and serotonin systems also play prominent roles in the activation of zif268 and c-fos by cocaine and amphetamine.	Norepinephrine	69-83	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	164-169
1355548-0	1992	Effects of platelet activating factor on contractions and 45Ca influx induced by noradrenaline and potassium in rat rubbed and intact aorta.	Norepinephrine	81-94	PCNA clamp associated factor	Rattus norvegicus	11-37
1355548-2	1992	In order to clarify the mechanism of hypotensive activity of platelet activating factor (PAF), the effects of this drug on blood pressure in anaesthetized normotensive rats, on KCl- and noradrenaline-induced 45Ca uptake and contractile responses in rat aorta rings with and without endothelium were studied.	Norepinephrine	186-199	PCNA clamp associated factor	Rattus norvegicus	61-87
1928327-2	1991	Prior exposure to PKC antagonists staurosporine (0.03 microM) and H-7 (10 microM) had relatively little effect on contractions to phorbol 12-myristate 13-acetate (PMA), while contractions to norepinephrine and KCl were greatly inhibited.	Norepinephrine	191-205	protein kinase C, gamma	Rattus norvegicus	18-21
1920125-1	1991	Neuropeptide Y (NPY) inhibits the release of noradrenaline (NA) or acetylcholine (ACh) from nerve terminals in the heart.	Norepinephrine	45-58	neuropeptide Y	Canis lupus familiaris	0-14
1920125-1	1991	Neuropeptide Y (NPY) inhibits the release of noradrenaline (NA) or acetylcholine (ACh) from nerve terminals in the heart.	Norepinephrine	45-58	neuropeptide Y	Canis lupus familiaris	16-19
1665390-5	1991	When two subsequent stimulations were performed in the same heart, adding exogenous noradrenaline before the second stimulation reduced NPY overflow on the contrary, and NPY decreased the overflow of noradrenaline.	Norepinephrine	84-97	pro-neuropeptide Y	Cavia porcellus	136-139
1665390-5	1991	When two subsequent stimulations were performed in the same heart, adding exogenous noradrenaline before the second stimulation reduced NPY overflow on the contrary, and NPY decreased the overflow of noradrenaline.	Norepinephrine	200-213	pro-neuropeptide Y	Cavia porcellus	170-173
1887900-5	1991	Norepinephrine infusion into the portal vein (1-5 micrograms.min-1.kg-1) caused Ppv to increase and the portal venous flow to decrease but did not significantly affect Phv.	Norepinephrine	0-14	protein phosphatase 6, catalytic subunit	Rattus norvegicus	80-83
1816758-3	1991	Endothelin-2 (10(-11)-10(-7) M) evoked a dose-dependent contractile response, having the same efficacy as noradrenaline and 100 times its potency.	Norepinephrine	106-119	endothelin 2	Homo sapiens	0-12
1654511-7	1991	In the presence of the beta-adrenergic receptor antagonist propranolol, norepinephrine activated a background current with properties similar to those of the PKC-sensitive current.	Norepinephrine	72-86	protein kinase C, gamma	Rattus norvegicus	158-161
1829900-1	1991	Previous studies from our laboratories have demonstrated a selective increase in stores of atrial natriuretic peptide (ANP) in the anterior hypothalamus of NaCl-sensitive spontaneously hypertensive rats (SHR-S) compared to NaCl-resistant Wistar-Kyoto (WKY) controls and have suggested that anterior hypothalamic ANP contributes to the pathogenesis of NaCl-sensitive hypertension in SHR-S by local inhibition of norepinephrine release.	Norepinephrine	411-425	natriuretic peptide A	Rattus norvegicus	91-117
1900942-0	1991	Norepinephrine and isoproterenol increase the phosphorylation of synapsin I and synapsin II in dentate slices of young but not aged Fisher 344 rats.	Norepinephrine	0-14	synapsin I	Rattus norvegicus	65-75
1671204-6	1991	Tissue culture in the presence of insulin increased the basal rate of lipolysis and increased the ratio of the rate of noradrenaline-stimulated/isoprenaline-stimulated lipolysis, indicating a decrease in the 2-adrenergic effect of noradrenaline.	Norepinephrine	119-132	LOC105613195	Ovis aries	34-41
1671204-6	1991	Tissue culture in the presence of insulin increased the basal rate of lipolysis and increased the ratio of the rate of noradrenaline-stimulated/isoprenaline-stimulated lipolysis, indicating a decrease in the 2-adrenergic effect of noradrenaline.	Norepinephrine	231-244	LOC105613195	Ovis aries	34-41
1962795-8	1990	Norepinephrine-precontracted aorta strips from rats receiving a non-pressor dose of angiotensin II were more sensitive to the relaxant effect of ANF.	Norepinephrine	0-14	natriuretic peptide A	Rattus norvegicus	145-148
2146891-3	1990	The release of ANP was markedly blunted to acute volume expansion (+67% vs. +357% in controls, P less than 0.01) but was only moderately reduced after norepinephrine infusion (+106% vs. +212%, P less than 0.05) and was normal after acute salt load [+148% vs. +180% in controls, not significant (NS)].	Norepinephrine	151-165	natriuretic peptide A	Rattus norvegicus	15-18
1973424-9	1990	The present study demonstrates that neuropeptide Y is co-released with noradrenaline from sympathetic nerve fibers during haemorrhage.	Norepinephrine	71-84	neuropeptide Y	Canis lupus familiaris	36-50
1973424-10	1990	Since the release of neuropeptide Y appeared to follow a similar time course to that of noradrenaline release, the present observations suggest that haemorrhagic hypotension enhances both neuropeptide Y and noradrenaline release presumably through a common releasing mechanism.	Norepinephrine	88-101	neuropeptide Y	Canis lupus familiaris	188-202
1973424-11	1990	These results also indicate that, in peripheral sympathetic nerves but not in the adrenal gland, neuropeptide Y release is also modulated presynaptically by the inhibitory alpha 2-adrenoceptors in conjunction with the noradrenaline release.	Norepinephrine	218-231	neuropeptide Y	Canis lupus familiaris	97-111
1701203-5	1990	ET-1 also enhanced both components of the response to high frequency field stimulation (2 to 16 Hz) and contractions induced by submaximal concentrations of noradrenaline, ATP or KCl.	Norepinephrine	157-170	DNA segment, Chr 9, MRC UK Mouse Genome Centre 40 expressed	Mus musculus	0-4
2314485-2	1990	PAF caused a dose-dependent vasodilation of norepinephrine-contracted mesenteric vascular bed, which was sensitive to CV-3988, a PAF antagonist, but insensitive to tetrodotoxin, atropine, propranolol and indomethacin.	Norepinephrine	44-58	PCNA clamp associated factor	Rattus norvegicus	0-3
2314485-2	1990	PAF caused a dose-dependent vasodilation of norepinephrine-contracted mesenteric vascular bed, which was sensitive to CV-3988, a PAF antagonist, but insensitive to tetrodotoxin, atropine, propranolol and indomethacin.	Norepinephrine	44-58	PCNA clamp associated factor	Rattus norvegicus	129-132
34973951-8	2022	Responses to intra-renal administration of adrenergic agonists including noradrenaline (NA), phenylephrine (PE), methoxamine (ME), and angiotensin-II (ANG-II) were larger in diabetic WKY, but significantly blunted with adiponectin treatment in diabetic WKYs to 35-40%, and further reduced by 65-70% in combination with pioglitazone.	Norepinephrine	73-86	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	219-230
34767786-8	2021	SIGNIFICANCE The beta2-adrenergic receptor (beta2 AR), which belongs to the vast family of Guanine nucleotide-binding protein coupled receptors (GPCRs), is a transmembrane protein that is activated by the catecholamines norepinephrine (noradrenaline) and epinephrine (adrenaline).	Norepinephrine	220-234	adrenoceptor beta 2	Homo sapiens	17-42
34767786-8	2021	SIGNIFICANCE The beta2-adrenergic receptor (beta2 AR), which belongs to the vast family of Guanine nucleotide-binding protein coupled receptors (GPCRs), is a transmembrane protein that is activated by the catecholamines norepinephrine (noradrenaline) and epinephrine (adrenaline).	Norepinephrine	236-249	adrenoceptor beta 2	Homo sapiens	17-42
34713714-14	2021	Finally, exposure of the renal epithelial cells to norepinephrine in vitro led to downregulation of GLP-1R expression but upregulation of neprilysin expression and activity.	Norepinephrine	51-65	glucagon-like peptide 1 receptor	Rattus norvegicus	100-106
34713714-14	2021	Finally, exposure of the renal epithelial cells to norepinephrine in vitro led to downregulation of GLP-1R expression but upregulation of neprilysin expression and activity.	Norepinephrine	51-65	membrane metallo-endopeptidase	Rattus norvegicus	138-148
34358571-10	2021	These findings demonstrate statistically significant relationships among vocal impairment, anxiety, and brainstem norepinephrine in the Pink1-/- rat model of PD.	Norepinephrine	114-128	PTEN induced kinase 1	Rattus norvegicus	136-141
34445205-8	2021	The reduced expression of NT-3, TrkC, and NET, and the lack of molecular complexes in T cells of patients with schizophrenia may lead to a peripheral dysregulation of intracellular signaling pathways and an abnormal reuptake of norepinephrine (NE) by NET.	Norepinephrine	228-242	neurotrophic receptor tyrosine kinase 3	Homo sapiens	32-36
34275002-9	2021	The expression of Bmal1, Per1 and Per3 in control subjects was also influenced by incubation with 1 microM norepinephrine.	Norepinephrine	107-121	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	18-23
34104992-3	2021	One such mechanism involves the direct inhibition by corticosteroid hormones of monoamine transport mediated by the "uptake2" transporter, organic cation transporter 3 (OCT3), a high-capacity, low-affinity transporter for norepinephrine, epinephrine, dopamine, serotonin, and histamine.	Norepinephrine	222-236	OCTN3	Homo sapiens	139-167
35174415-3	2022	Aims of the study were to monitor the effect of a single session of dTMS on body temperature in subjects with obesity, and to correlate the dTMS-induced changes in body temperature with activation of the SNS (epinephrine and norepinephrine release).	Norepinephrine	225-239	tms	Drosophila melanogaster	140-144
35264016-3	2022	Given that an increase in cardiac mass is often caused by adrenergic hyperactivity, we hypothesized that VAChT KDHOM mice might have an increase in cardiac norepinephrine (NE) levels.	Norepinephrine	156-170	solute carrier family 18 (vesicular monoamine), member 3	Mus musculus	105-110
35245122-1	2022	The alpha2A adrenergic receptor (alpha2AAR) is a G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor that mediates important physiological functions in response to the endogenous neurotransmitters norepinephrine and epinephrine, as well as numerous chemically distinct drugs.	Norepinephrine	224-238	adrenoceptor alpha 2A	Homo sapiens	4-31
35245122-1	2022	The alpha2A adrenergic receptor (alpha2AAR) is a G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor that mediates important physiological functions in response to the endogenous neurotransmitters norepinephrine and epinephrine, as well as numerous chemically distinct drugs.	Norepinephrine	224-238	adrenoceptor alpha 2A	Homo sapiens	33-42
35245122-3	2022	Here, we report the cryo-electron microscopy structures of the human alpha2AAR-GoA complex bound to norepinephrine and three imidazoline derivatives (brimonidine, dexmedetomidine, and oxymetazoline).	Norepinephrine	100-114	adrenoceptor alpha 2A	Homo sapiens	69-78
35245122-5	2022	Further structural analyses uncover different molecular determinants between alpha2AAR and betaARs for recognition of norepinephrine and key regions that determine the G protein coupling selectivity.	Norepinephrine	118-132	adrenoceptor alpha 2A	Homo sapiens	77-86
2676489-4	1989	Labeling of consecutive sections with phenylethanolamine-N-methyltransferase or AVT antibodies showed that both noradrenaline- and adrenaline-storing cells contain AVT-like immunoreactivity.	Norepinephrine	112-125	phenylethanolamine N-methyltransferase	Canis lupus familiaris	38-76
2776842-4	1989	Pretreating the coronary system of these hearts with NPY caused a marked potentiation of the vasocontractile effect of noradrenaline, displacing its dose-response curve to the left in a non-parallel fashion.	Norepinephrine	119-132	neuropeptide Y	Canis lupus familiaris	53-56
2569455-5	1989	Propranolol had no significant effect on the response to nerve stimulation, whereas ICI 118551, a selective beta 2-adrenoceptor antagonist, enhanced responses to nerve stimulation and injected norepinephrine.	Norepinephrine	193-207	adrenoceptor beta 2	Homo sapiens	108-127
2714445-4	1989	3-Hydroxytyramine (DA) and norepinephrine (NE) also increased the cellular NGF mRNA content.	Norepinephrine	27-41	nerve growth factor	Mus musculus	75-78
2537155-2	1989	Melittin, a polypeptide found in honeybee venom and a known activator of phospholipase A2, induced transient, endothelium-dependent relaxations of rat thoracic aortae contracted with norepinephrine.	Norepinephrine	183-197	melittin	Apis mellifera	0-8
2677641-5	1989	Caffeine and norepinephrine release Ca2+ from this store to induce a transient contraction.	Norepinephrine	13-27	carbonic anhydrase 2	Homo sapiens	36-39
2634963-1	1989	The effects of L-adrenaline and L-noradrenaline on human lecithin: cholesterol acyltransferase (LCAT) activity were investigated in vitro.	Norepinephrine	32-47	lecithin-cholesterol acyltransferase	Homo sapiens	96-100
2471016-9	1989	In norepinephrine-treated animals, adipose tissue lipoprotein lipase activity was enhanced (+30%) by doxazosin.	Norepinephrine	3-17	lipoprotein lipase	Mesocricetus auratus	50-68
2473320-1	1989	Addition of endothelin-1 (ET-1) to primary cultures of bovine adrenal chromaffin cells causes a significant enhancement of norepinephrine and epinephrine efflux, with an EC50 of about 1 nM.	Norepinephrine	123-137	endothelin 1	Bos taurus	12-24
2473320-1	1989	Addition of endothelin-1 (ET-1) to primary cultures of bovine adrenal chromaffin cells causes a significant enhancement of norepinephrine and epinephrine efflux, with an EC50 of about 1 nM.	Norepinephrine	123-137	endothelin 1	Bos taurus	26-30
2473320-3	1989	The amounts of noradrenaline and adrenaline released by ET-1 was smaller than the release elicited by maximally effective concentrations of bradykinin or prostaglandin E2.	Norepinephrine	15-28	endothelin 1	Bos taurus	56-60
3241276-2	1988	In the pithed rat the increase in diastolic blood pressure elicited by Ang II consisted of an interaction with the sympathetic nervous system involving presynaptically released noradrenaline and of a direct stimulation of postsynaptic Ang II-receptors on vascular smooth muscle.	Norepinephrine	177-190	angiogenin	Rattus norvegicus	71-74
3247254-1	1988	This investigation was undertaken in the unrestrained rat to determine the localized effect of neurotensin (NT) on the profile of release and turnover of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) within the hypothalamus.	Norepinephrine	154-168	neurotensin	Rattus norvegicus	95-106
3247254-1	1988	This investigation was undertaken in the unrestrained rat to determine the localized effect of neurotensin (NT) on the profile of release and turnover of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) within the hypothalamus.	Norepinephrine	154-168	neurotensin	Rattus norvegicus	108-110
2842284-5	1988	Synthesis of mucin, and its secretion in response to norepinephrine or cAMP, dropped precipitously to very low levels after 2 d. However, synthesis of DNA, general proteins, and glycoproteins dropped only transiently after 2 d, rising to levels approaching those of freshly dissociated complexes by 22 d. These data indicate that a shift occurred from the synthesis of large quantities of secretory proteins and glycoproteins, especially mucins, during the first 2 d in culture, to other materials thereafter.	Norepinephrine	53-67	solute carrier family 13 member 2	Rattus norvegicus	13-18
2969977-3	1988	In the present study, we utilized an in vitro perfused hydronephrotic rat kidney model to assess directly the actions of ANP on renal microvessels during norepinephrine (NE)-induced renal vasoconstriction.	Norepinephrine	154-168	natriuretic peptide A	Rattus norvegicus	121-124
2969821-0	1988	Atrial natriuretic factor inhibits norepinephrine release in an adrenergic clonal cell line (PC12).	Norepinephrine	35-49	natriuretic peptide A	Rattus norvegicus	0-25
2454064-3	1988	Every preparation treated with somatostatin, and one tissue treated with NPY, showed an enhanced noradrenaline-induced contraction.	Norepinephrine	97-110	neuropeptide Y	Canis lupus familiaris	73-76
2839012-6	1988	Catecholamines (epinephrine, norepinephrine and isoproterenol) reduced the basal secretion of ANP, whereas acetylcholine stimulated the release of ANP.	Norepinephrine	29-43	natriuretic peptide A	Rattus norvegicus	94-97
3227888-2	1988	The effects of noradrenaline (NA)-induced vasoconstriction on the transcapillary passage of albumin was evaluated by an external detection technique, allowing repetitive measurements of albumin clearance (Cl) during various conditions (in the same animal).	Norepinephrine	15-28	albumin	Rattus norvegicus	92-99
3227888-2	1988	The effects of noradrenaline (NA)-induced vasoconstriction on the transcapillary passage of albumin was evaluated by an external detection technique, allowing repetitive measurements of albumin clearance (Cl) during various conditions (in the same animal).	Norepinephrine	15-28	albumin	Rattus norvegicus	186-193
3382942-1	1988	The apparently non-specific accumulation of c-fos proto-oncogene mRNA was found in rat hippocampus as a result of injection of either glutamate, noradrenaline, or physiological saline.	Norepinephrine	145-158	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	44-49
3260379-3	1988	MPTP produced dose-dependent marked reductions in the concentrations of dopamine and noradrenaline in mouse brain 2 hours as well as 7 days after the administration.	Norepinephrine	85-98	calbindin 1	Mus musculus	108-115
3371399-6	1988	NPY suppressed the contractile effect of noradrenaline (NA) on isolated cerebral arteries and pretreatment with NPY suppressed the effect of NA on VBF, indicating that NPY contributes to the inhibitory modulation of postsynaptic adrenergic mechanisms.	Norepinephrine	41-54	neuropeptide Y	Canis lupus familiaris	0-3
2840274-5	1988	The DHEA-S concentration in the medium was significantly increased by angiotensin-II (10(-7)M), noradrenalin (3 X 10(-5) M), adrenalin (3 X 10(-5) M) or alpha-melanocyte-stimulating hormone (alpha-MSH, 10(-7) M), none of which was associated with cAMP production.	Norepinephrine	96-108	sulfotransferase family 2A member 1	Homo sapiens	4-10
3143879-3	1988	A 1-hr pretreatment, but not a 24-hr pretreatment, with the monoamine oxidase B inhibitor, L-deprenyl (10 mg/kg ip), prevented the depletion of norepinephrine by xylamine.	Norepinephrine	144-158	monoamine oxidase B	Rattus norvegicus	60-79
3427094-6	1987	The inhibition by thyroid hormones may have implications for regulation of ADH catalysis of ethanol and alcohols in the intermediary metabolism of dopamine, norepinephrine, and serotonin and in steroid metabolism.	Norepinephrine	157-171	aldo-keto reductase family 1 member A1	Homo sapiens	75-78
2890660-5	1987	Superfusion with 10 muM norepinephrine produced a biphasic rise in ANP secretion with a peak response 2.5-fold above baseline secretion.	Norepinephrine	24-38	natriuretic peptide A	Rattus norvegicus	67-70
3138899-1	1987	Rat growth hormone-releasing factor (rGRF) and norepinephrine (NE) stimulate secretion of calcitonin (CT) and neurotensin (NT) from cultured C-cells.	Norepinephrine	47-61	neurotensin	Rattus norvegicus	110-121
3440821-4	1987	It is suggested that NPY is released from cardiac sympathetic neurons with noradrenaline following activation of the sympathetic nerve and inhibits cardiac vagal action.	Norepinephrine	75-88	neuropeptide Y	Canis lupus familiaris	21-24
3040721-6	1987	The adrenergic agonists isoproterenol and norepinephrine blocked the elevation of cellular c-sis mRNA accompanying exposure to either thrombin or TGF-beta.	Norepinephrine	42-56	platelet derived growth factor subunit B	Homo sapiens	91-96
2890184-3	1987	Somatostatin potentiates the venoconstrictive activity of noradrenaline, adrenaline and dopamine, but not that of 5-hydroxytryptamine and tyramine.	Norepinephrine	58-71	somatostatin	Homo sapiens	0-12
2882402-2	1987	Norepinephrine had a potent inhibitory effect on I-CRF release in a dose-dependent manner at 0.1 nM-1 microM concentrations, but dopamine did not.	Norepinephrine	0-14	regenerating family member 1 alpha	Rattus norvegicus	49-54
2882402-6	1987	These results suggest that norepinephrine inhibits I-CRF release mainly through the beta-adrenergic receptor and partially through the alpha 1-receptor.	Norepinephrine	27-41	regenerating family member 1 alpha	Rattus norvegicus	51-56
3031661-5	1987	Additional studies with muscle slices incubated with [3H]norepinephrine or [3H]choline showed that neuropeptide Y stimulated norepinephrine release from sympathetic nerves, which, in turn, inhibited the release of acetylcholine via alpha 2 receptors located on postganglionic nerves.	Norepinephrine	57-71	pro-neuropeptide Y	Cavia porcellus	99-113
3611599-1	1987	In agreement with the inhibition of dopamine-beta-hydroxylase by exposure to CS2, the extension of exposure time from 4 to 16 h increased dopamine concentrations in the hypothalmus and adrenals, and decreased noradrenaline concentration in the hypothalmus.	Norepinephrine	209-222	calsyntenin 2	Rattus norvegicus	77-80
3466164-0	1986	Human class II (pi) alcohol dehydrogenase has a redox-specific function in norepinephrine metabolism.	Norepinephrine	75-89	aldo-keto reductase family 1 member A1	Homo sapiens	20-41
3466164-7	1986	These features and the presence of pi ADH in human liver imply a physiological role for pi ADH in the degradation of circulating epinephrine and norepinephrine.	Norepinephrine	145-159	aldo-keto reductase family 1 member A1	Homo sapiens	38-41
3466164-7	1986	These features and the presence of pi ADH in human liver imply a physiological role for pi ADH in the degradation of circulating epinephrine and norepinephrine.	Norepinephrine	145-159	aldo-keto reductase family 1 member A1	Homo sapiens	91-94
2945673-7	1986	There was an excellent correlation between plasma norepinephrine and renin activity before the animals were killed in both the VP1 and VP2 groups (r = .88, p less than .001).	Norepinephrine	50-64	renin	Canis lupus familiaris	69-74
2434752-6	1986	In addition, on atria and on ventricles, adenylate cyclase was activated by norepinephrine (presumably by beta 1- and beta 2-adrenoceptor stimulation) and by procaterol (by beta 2-adrenoceptor stimulation).	Norepinephrine	76-90	adrenoceptor beta 2	Homo sapiens	118-137
3536002-0	1986	CCK and other peptides modulate hypothalamic norepinephrine release in the rat: dependence on hunger or satiety.	Norepinephrine	45-59	cholecystokinin	Rattus norvegicus	0-3
3019887-2	1986	Norepinephrine, epinephrine, and phenylephrine stimulated tonin release, an effect that was inhibited by phentolamine but not by propranolol, whereas isoproterenol, carbachol, histamine, and serotonin did not stimulate tonin release.	Norepinephrine	0-14	kallikrein 1-related peptidase C2	Rattus norvegicus	58-63
3019887-2	1986	Norepinephrine, epinephrine, and phenylephrine stimulated tonin release, an effect that was inhibited by phentolamine but not by propranolol, whereas isoproterenol, carbachol, histamine, and serotonin did not stimulate tonin release.	Norepinephrine	0-14	kallikrein 1-related peptidase C2	Rattus norvegicus	195-200
3019887-6	1986	The apparent molecular size of immunoreactive tonin released into the medium under basal and norepinephrine-stimulated conditions was similar to that of standard tonin by gel exclusion chromatography.	Norepinephrine	93-107	kallikrein 1-related peptidase C2	Rattus norvegicus	46-51
3021940-8	1986	Angiotensin II secreted from the vascular bed by the beta 2-adrenoceptor stimulation acts locally to facilitate norepinephrine release.	Norepinephrine	112-126	adrenoceptor beta 2	Homo sapiens	53-72
2875175-2	1986	Maximum contraction with thrombin represented between 50 and 66% of the maximum arterial response to norepinephrine (NE).	Norepinephrine	101-115	prothrombin	Oryctolagus cuniculus	25-33
3762738-1	1986	Utilizing a specific "low substrate concentration technique", intrasynaptosomal MAO-A and MAO-B activities within the rat brain noradrenaline system were studied.	Norepinephrine	128-141	monoamine oxidase B	Rattus norvegicus	90-95
3717362-6	1986	ADA completely blocked the norepinephrine-induced vasodilation (n = 6).	Norepinephrine	27-41	adenosine deaminase	Canis lupus familiaris	0-3
3700383-3	1986	Treatment of the cells with either norepinephrine or epinephrine in the range of 0.05-0.2 mM for 24 h resulted in a 3-20-fold increase in NGF content in the medium of the L-M cells.	Norepinephrine	35-49	nerve growth factor	Mus musculus	138-141
3700383-7	1986	These results suggested that norepinephrine and epinephrine stimulated the de novo synthesis and secretion of NGF protein.	Norepinephrine	29-43	nerve growth factor	Mus musculus	110-113
2941312-0	1986	Atrial natriuretic factor inhibits norepinephrine release evoked by sympathetic nerve stimulation in isolated perfused rat mesenteric arteries.	Norepinephrine	35-49	natriuretic peptide A	Rattus norvegicus	0-25
3754217-3	1986	Neuropeptide Y, on a molar basis, was 7 and 120 times less potent than noradrenaline and angiotensin, respectively, in producing a 50 mm Hg rise in mean arterial blood pressure.	Norepinephrine	71-84	neuropeptide Y	Felis catus	0-14
3754217-5	1986	Neuropeptide Y had a similar potency to noradrenaline in causing these resistance changes.	Norepinephrine	40-53	neuropeptide Y	Felis catus	0-14
2948068-0	1986	Human atrial natriuretic factor prevents against norepinephrine-induced acute renal failure in the rat.	Norepinephrine	49-63	natriuretic peptide A	Rattus norvegicus	6-31
2948068-1	1986	The aim of the present study was to investigate the potential protective effect of atrial natriuretic factor (ANF) on the norepinephrine (NE)-induced acute renal failure (ARF).	Norepinephrine	122-136	natriuretic peptide A	Rattus norvegicus	83-108
2948068-1	1986	The aim of the present study was to investigate the potential protective effect of atrial natriuretic factor (ANF) on the norepinephrine (NE)-induced acute renal failure (ARF).	Norepinephrine	122-136	natriuretic peptide A	Rattus norvegicus	110-113
2948068-5	1986	ANF pretreatment prevented the norepinephrine-induced ARF.	Norepinephrine	31-45	natriuretic peptide A	Rattus norvegicus	0-3
20493043-2	1986	Noradrenaline synthesis is depressed by adenosine deaminase and the adenosine antagonist, 8-phenyltheophylline and stimulated by the adenosine agonist, 2-chloroadenosine.	Norepinephrine	0-13	adenosine deaminase	Rattus norvegicus	40-59
2935879-2	1986	We have now found that this natriuretic effect of ANF is associated with a suppression of the initially elevated urinary excretion of norepinephrine and epinephrine and increase of the excretion of the main dopamine metabolite-dihydroxyphenylacetic acid as well as of the urinary dopamine to norepinephrine ratio.	Norepinephrine	134-148	natriuretic peptide A	Rattus norvegicus	50-53
2935879-2	1986	We have now found that this natriuretic effect of ANF is associated with a suppression of the initially elevated urinary excretion of norepinephrine and epinephrine and increase of the excretion of the main dopamine metabolite-dihydroxyphenylacetic acid as well as of the urinary dopamine to norepinephrine ratio.	Norepinephrine	292-306	natriuretic peptide A	Rattus norvegicus	50-53
2856724-2	1985	Synthetic ANF caused a relaxation of the renal vessels when these were submaximally activated with noradrenaline or serotonin, but had no effect on the responses of the other vessels to these agonists.	Norepinephrine	99-112	natriuretic peptide A	Rattus norvegicus	10-13
2999616-13	1985	As expected from beta 1-adrenoceptors, the high-sensitivity component of the curve for (-)-noradrenaline was selectively antagonized by (-)-bisoprolol; as expected from beta 2-adrenoceptors, the low-sensitivity component was selectively antagonized by ICI 118,551.	Norepinephrine	87-104	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	17-23
4041988-2	1985	An injection of ovine GH (6 or 100 micrograms/kg) into a cephalic vein produced in the hepatic portal circulation a transient, statistically significant rise of serotonin and a concomitant significant reduction in the concentration of dopamine, norepinephrine, and epinephrine.	Norepinephrine	245-259	somatotropin	Canis lupus familiaris	22-24
3872460-2	1985	N-Methyl-4-phenylpyridine (MPP+), a metabolite of MPTP formed by monoamine oxidase B, is accumulated into striatal and cerebral cortical synaptosomes by the dopamine and norepinephrine uptake systems, respectively, whereas MPTP itself is not accumulated.	Norepinephrine	170-184	monoamine oxidase B	Rattus norvegicus	65-84
3921855-7	1985	Even in intact tissues MAO B may play a role in the metabolism (but not in the inactivation) of noradrenaline by deaminating the NMN formed from noradrenaline and giving preferentially origin to MOPEG.	Norepinephrine	96-109	monoamine oxidase B	Canis lupus familiaris	23-28
3921855-7	1985	Even in intact tissues MAO B may play a role in the metabolism (but not in the inactivation) of noradrenaline by deaminating the NMN formed from noradrenaline and giving preferentially origin to MOPEG.	Norepinephrine	145-158	monoamine oxidase B	Canis lupus familiaris	23-28
3921856-0	1985	Influence of MAO A and MAO B on the inactivation of noradrenaline in the saphenous vein of the dog.	Norepinephrine	52-65	monoamine oxidase B	Canis lupus familiaris	23-28
3978237-3	1985	The present study reports that bovine PTH-(1-34) can relax isolated rat tail artery helical strips precontracted by either arginine vasopressin, depolarizing concentrations of potassium chloride, or norepinephrine.	Norepinephrine	199-213	parathyroid hormone	Bos taurus	38-41
6548381-0	1984	Neurochemical properties of AHR-9377: a novel inhibitor of norepinephrine reuptake.	Norepinephrine	59-73	aryl hydrocarbon receptor	Rattus norvegicus	28-31
6548381-1	1984	A novel potential antidepressant, AHR-9377, was evaluated for its inhibition of norepinephrine (NE), serotonin (5-HT) and dopamine (DA) reuptake in hypothalmic, cortical, and striatal rat synaptosomal preparations.	Norepinephrine	80-94	aryl hydrocarbon receptor	Rattus norvegicus	34-37
6522106-6	1984	ADP associated with thrombin failed to trigger formation of microthrombi but initiated platelet-rich thrombi in the pulmonary vasculature when associated with norepinephrine.	Norepinephrine	159-173	prothrombin	Oryctolagus cuniculus	20-28
6522106-8	1984	Furthermore, the ability of norepinephrine to elicit glomerular thrombosis in thrombin injected rabbits may provide an explanation for requirement of alpha-adrenergic stimulation in the endotoxin-induced generalized Shwartzman reaction.	Norepinephrine	28-42	prothrombin	Oryctolagus cuniculus	78-86
6088536-8	1984	Pulse-label and pulse-chase studies indicate that the conversion rate of phosphocholine to CDP-choline, catalyzed by CTP:phosphocholine cytidylyltransferase, is diminished by norepinephrine.	Norepinephrine	175-189	phosphate cytidylyltransferase 1A, choline	Rattus norvegicus	117-156
6541480-5	1984	The dose-response relationships determined for the four peptides in relaxing norepinephrine-induced contraction of rabbit thoracic aorta showed half-maximum relaxation at concentrations ranging from 1.5 X 10(-9) to 2.5 X 10(-9) M. Comparable dose-response relationships were observed in relaxation of carbacol-induced contraction of chick rectum strips as tested with ANF-II and ANF-IV.	Norepinephrine	77-91	natriuretic peptide A	Rattus norvegicus	368-371
6541480-5	1984	The dose-response relationships determined for the four peptides in relaxing norepinephrine-induced contraction of rabbit thoracic aorta showed half-maximum relaxation at concentrations ranging from 1.5 X 10(-9) to 2.5 X 10(-9) M. Comparable dose-response relationships were observed in relaxation of carbacol-induced contraction of chick rectum strips as tested with ANF-II and ANF-IV.	Norepinephrine	77-91	natriuretic peptide A	Rattus norvegicus	379-382
6205029-8	1984	However, mucin release after treatment with SP followed by norepinephrine (NE) was 161% of that caused by NE alone (p less than 0.01) and may reflect an additive response to the independent stimulation of SP and NE receptors.	Norepinephrine	59-73	solute carrier family 13 member 2	Rattus norvegicus	9-14
6146262-3	1984	Likewise, several neuropeptides, e.g., bombesin, corticotropin-releasing factor, thyrotropin-releasing factor, and somatostatin-related peptides, act within the central nervous system to produce differential changes in the relative concentrations of epinephrine and norepinephrine in plasma.	Norepinephrine	266-280	gastrin releasing peptide	Homo sapiens	39-47
6326156-4	1984	Intravenous infusion of ANF in the bilaterally nephrectomized, hexamethonium-treated rat produces only a small transient pressor response, probably due to potentiation of endogenous norepinephrine.	Norepinephrine	182-196	natriuretic peptide A	Rattus norvegicus	24-27
6326157-5	1984	By contrast, peripherally administered isoproterenol, norepinephrine or epinephrine, each increased plasma levels of alpha-MSH-LI together with beta-END-LI in a dose-dependent manner.	Norepinephrine	54-68	proopiomelanocortin	Rattus norvegicus	117-126
6539299-0	1984	Atrial natriuretic factor inhibits angiotensin-, norepinephrine-, and potassium-induced vascular contractility.	Norepinephrine	49-63	natriuretic peptide A	Rattus norvegicus	0-25
6143680-2	1984	retarded the disappearance of noradrenaline induced by the dopamine-beta-hydroxylase (DBH) inhibitor FLA 63, in the hypothalamus, nucleus of the solitary tract (A-2/C-2 area), and lateral reticular nucleus (A-1/C-1 area) regions, while propranolol (20 mg/kg i.p.)	Norepinephrine	30-43	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	207-214
6141513-3	1984	Acute pretreatment with the selective inhibitor of norepinephrine (NE) synthesis, DU-18288, or with a potent antagonist of presynaptic alpha 2-receptors, mianserin abolished the GH rise induced by CLON (4 /micrograms/Kg iv).	Norepinephrine	51-65	somatotropin	Canis lupus familiaris	178-180
6397510-6	1983	Mean plasma concentrations of renin, angiotensin II and aldosterone tended to be lower during prolonged infusion of noradrenaline, but only the fall of renin during the second week was significant in one group of dogs.	Norepinephrine	116-129	renin	Canis lupus familiaris	30-35
6397510-7	1983	Noradrenaline at higher rates significantly raised blood pressure and increased plasma concentrations of renin and angiotensin II.	Norepinephrine	0-13	renin	Canis lupus familiaris	105-129
6132592-5	1983	We also observed significant correlations between somatostatin and 5-hydroxyindoleacetic acid and norepinephrine in the CSF.	Norepinephrine	98-112	somatostatin	Homo sapiens	50-62
6841966-1	1983	Norepinephrine concentration of the whole brain was found to be statistically different between the HBP and LBP mouse stains that had been selectively bred for high and low systolic blood pressure, respectively.	Norepinephrine	0-14	lipopolysaccharide binding protein	Mus musculus	108-111
6341134-0	1983	Differences between the effects of adrenaline and noradrenaline on insulin secretion in the dog.	Norepinephrine	50-63	insulin	Canis lupus familiaris	67-74
6341134-7	1983	In hyperglycaemic dogs, adrenaline (2 micrograms X kg-1 X min-1) reduced the insulin response and enhanced the hyperglycaemia; noradrenaline (2 micrograms X kg-1 X min-1) markedly increased the insulin response (+ 2250%) without any significant change in blood glucose.	Norepinephrine	127-140	insulin	Canis lupus familiaris	194-201
6341134-8	1983	Propranolol (0.3 mg/kg, IV) prevented the increase of insulin induced by noradrenaline.	Norepinephrine	73-86	insulin	Canis lupus familiaris	54-61
6341134-9	1983	These findings show that, in the normal dog, adrenaline and noradrenaline infusions can produce opposite effects on insulin response depending on the experimental conditions.	Norepinephrine	60-73	insulin	Canis lupus familiaris	116-123
6131439-9	1983	We conclude that neurotensin may play a role in short-term appetite regulation by a complex interaction with monoamines and neuropeptides, particularly norepinephrine and the kappa opiate agonist, dynorphin.	Norepinephrine	152-166	neurotensin	Rattus norvegicus	17-28
6295549-0	1982	Effects of norepinephrine and serotonin upon spontaneous activity and responses to mossy fiber stimulation of CA3 neurons in hippocampal slices.	Norepinephrine	11-25	carbonic anhydrase 3	Rattus norvegicus	110-113
7159481-6	1982	In contrast, the MAO-B in human platelets deaminated l-norepinephrine more readily than serotonin.	Norepinephrine	53-69	monoamine oxidase B	Homo sapiens	17-22
7159481-7	1982	Thus, l-norepinephrine, like dopamine, should be regarded as a substrate for both MAO-A and MAO-B in vitro.	Norepinephrine	6-22	monoamine oxidase B	Homo sapiens	92-97
7159481-8	1982	The prominent role of MAO-B in norepinephrine degradation in primates may need to be considered in interpreting laboratory and clinical studies of clorgyline and other selective MAO-inhibiting drugs.	Norepinephrine	31-45	monoamine oxidase B	Homo sapiens	22-27
6821292-6	1982	These results suggest that mechanism of the improvement of ataxic gait by TRH may not be sufficiently explained through only changing norepinephrine metabolism.	Norepinephrine	134-148	thyrotropin releasing hormone	Mus musculus	74-77
7175524-0	1982	Effects of Cd2+, Mn2+, and Al3+ on rat brain synaptosomal uptake of noradrenaline and serotonin.	Norepinephrine	68-81	Cd2 molecule	Rattus norvegicus	11-14
7175524-2	1982	In the absence of Ca2+, the rank order of inhibition of noradrenaline uptake was: Cd2+ (IC50 = 250 microM) greater than Al3+ (IC50 = 430 microM) greater than Mn2+ (IC50 = 1.50 mM), the IC50 being the concentration of metal ions that gave rise to 50% inhibition of uptake.	Norepinephrine	56-69	Cd2 molecule	Rattus norvegicus	82-85
7175524-5	1982	Ca2+, at 1 mM, definitely antagonized the inhibitory actions of Cd2+ on noradrenaline and serotonin uptake.	Norepinephrine	72-85	Cd2 molecule	Rattus norvegicus	64-67
7127680-7	1982	In the veins, arachidonic acid and thrombin caused endothelium-dependent increases in tension during contractions evoked by norepinephrine.	Norepinephrine	124-138	coagulation factor II, thrombin	Bos taurus	35-43
6212052-9	1982	The effect of noradrenaline appeared to be exerted through a beta- rather than an alpha-type of adrenoceptor.	Norepinephrine	14-27	amyloid beta precursor protein	Rattus norvegicus	59-65
7071077-4	1982	The putative satiety hormones, bombesin (10 micrograms/kg; subcutaneously) and cholecystokinin octapeptide (10 micrograms/kg; subcutaneously) also reduced norepinephrine induced eating, as did ICV administration of calcitonin (2 units).	Norepinephrine	155-169	gastrin releasing peptide	Homo sapiens	31-39
7054638-0	1982	Neurotensin-induced release of endogenous noradrenaline from rat hypothalamic slices.	Norepinephrine	42-55	neurotensin	Rattus norvegicus	0-11
6175823-0	1982	Prolonged infusion of norepinephrine in the conscious dog: effects on blood pressure, heart rate, renin, angiotensin II, and aldosterone.	Norepinephrine	22-36	renin	Canis lupus familiaris	98-103
6127639-2	1982	The catecholamines dopamine (DA) and norepinephrine (NE) inhibited the release of alpha-MSH from pituitary glands incubated in vitro.	Norepinephrine	37-51	proopiomelanocortin	Rattus norvegicus	82-91
7040635-5	1981	Infusion noradrenaline by either route resulted in dose-related rises in plasma renin activity.	Norepinephrine	9-22	renin	Canis lupus familiaris	80-85
6274461-0	1981	Insulin-induced enhancement of uptake of noradrenaline in atrial strips.	Norepinephrine	41-54	insulin	Cavia porcellus	0-7
6274461-3	1981	3 The response os isolated atria to noradrenaline was significantly reduced in the presence of insulin.	Norepinephrine	36-49	insulin	Cavia porcellus	95-102
6274461-7	1981	6 The ability of insulin to facilitate uptake of noradrenaline would be expected to cause a decrease in the amount of the amine reaching the receptors, thus leading to a diminished response to this amine.	Norepinephrine	49-62	insulin	Cavia porcellus	17-24
6274461-8	1981	This may explain, at least in part, insulin-induced subsensitivity to noradrenaline.	Norepinephrine	70-83	insulin	Cavia porcellus	36-43
7320735-1	1981	The circadian release of norepinephrine from nerve terminals in the pineal gland drives acetyl-CoA:serotonin N-acetyltransferase (NAT; EC 2.3.1.5) activity in the adult pineal from a daytime low to a nighttime high.	Norepinephrine	25-39	aralkylamine N-acetyltransferase	Homo sapiens	99-128
7320735-1	1981	The circadian release of norepinephrine from nerve terminals in the pineal gland drives acetyl-CoA:serotonin N-acetyltransferase (NAT; EC 2.3.1.5) activity in the adult pineal from a daytime low to a nighttime high.	Norepinephrine	25-39	bromodomain containing 2	Homo sapiens	130-133
6271374-0	1981	Effects of tonin on the response to norepinephrine by the aortic strip of the hypertensive rat.	Norepinephrine	36-50	kallikrein 1-related peptidase C2	Rattus norvegicus	11-16
7017342-4	1981	Acute replacement (8 units PZI) 12hr before the measurements resulted in resting and noradrenaline-stimulated values for VO2 that were similar to those of non-diabetic cafeteria rats.	Norepinephrine	85-98	serpin family A member 10	Rattus norvegicus	27-30
6270688-1	1981	Studies of the adrenergic regulation of cyclic GMP in the pineal gland show that (-)-norepinephrine stimulates cyclic GMP primarily in pineal cells, rather than in nerve endings as previously thought.	Norepinephrine	81-99	5'-nucleotidase, cytosolic II	Homo sapiens	47-50
6270688-1	1981	Studies of the adrenergic regulation of cyclic GMP in the pineal gland show that (-)-norepinephrine stimulates cyclic GMP primarily in pineal cells, rather than in nerve endings as previously thought.	Norepinephrine	81-99	5'-nucleotidase, cytosolic II	Homo sapiens	118-121
7011963-8	1981	The CSF norepinephrine was related inversely to the CSF sodium concentration and directly to plasma renin activity.	Norepinephrine	8-22	renin	Canis lupus familiaris	100-105
6109792-6	1981	Both carbachol- and norepinephrine-mediated gastrin release are modified by somatostatin and adenosine.	Norepinephrine	20-34	gastrin	Rattus norvegicus	44-51
7253345-9	1981	These results suggest that C8-CCK enhances the contractile and relaxing responses to noradrenaline, and that prostaglandins act in a similar way on the postsynaptic response and, in addition, inhibit presynaptically the release of noradrenaline in the gallbladder.	Norepinephrine	85-98	cholecystokinin	Cavia porcellus	30-33
7218373-3	1981	Depressant responses of cortical neurones to noradrenaline were also markedly potentiated by weak background application of p-TA.	Norepinephrine	45-58	pre T-cell antigen receptor alpha	Rattus norvegicus	124-128
6256117-8	1980	Tonin potentiated the contraction induced by noradrenaline in aortic strips from hypertensive and normotensive rats.	Norepinephrine	45-58	kallikrein 1-related peptidase C2	Rattus norvegicus	0-5
6256117-10	1980	In the aortic and mesenteric strips from normal rabbits, tonin produced not only potentiation to noradrenaline but direct contraction.	Norepinephrine	97-110	kallikrein 1-related peptidase C2	Rattus norvegicus	57-62
6256117-12	1980	The potentiation to noradrenaline and the direct effect of tonin were not affected by a variety of antagonists but were blocked by a calcium ion antagonist, verapamil, suggesting that tonin may act directly on vascular smooth muscle through mechanisms which might be mediated by calcium ions.	Norepinephrine	20-33	kallikrein 1-related peptidase C2	Rattus norvegicus	184-189
6968237-1	1980	The responsiveness of hippocampal CA3 pyramidal neurons to microiontophoretic applications of serotonin (5-HT), norepinephrine (NE), gamma-aminobutyric acid (GABA) and isoproterenol (ISO) was assessed in rats following 5,7-dihydroxy-tryptamine (5,7-DHT) and 6-hydroxydopamine (6-OHDA) pretreatments and bilateral locus coeruleus lesions.	Norepinephrine	112-126	carbonic anhydrase 3	Rattus norvegicus	34-37
6252494-0	1980	The kinetics of norepinephrine-induced stimulation of serotonin N-acetyltransferase in bovine pineal gland.	Norepinephrine	16-30	serotonin N-acetyltransferase	Bos taurus	54-83
7255763-8	1980	The potent inhibitory effects of locally applied NT appear to result from release of the inhibitory transmitter, norepinephrine from locus coeruleus-derived afferents.	Norepinephrine	113-127	neurotensin	Rattus norvegicus	49-51
7255763-9	1980	We postulate that the excitations, which appear when postsynaptic effects of norepinephrine are antagonized or release is reduced, may be the direct result of NT action at the postsynaptic P neuron membrane.	Norepinephrine	77-91	neurotensin	Rattus norvegicus	159-161
6105122-1	1980	In vitro incubation studies with bovine parathyroid gland slices compared the relative responsiveness of parathyroid hormone (PTH) secretion to isoprotherenol, epinephrine or norepinephrine.	Norepinephrine	175-189	parathyroid hormone	Bos taurus	105-124
7463880-3	1980	However, since a tendency to increase in norepinephrine turnover rate after CCK injection was noticed, the possibility that brain monoamines are involved in the central action of CCK could not be excluded.	Norepinephrine	41-55	cholecystokinin	Rattus norvegicus	76-79
222624-4	1979	beta-Endorphin, VIP, secretin, and glucagon all produce discrete changes in norepinephrine turnover in various hypothalamic nuclei.	Norepinephrine	76-90	secretin	Rattus norvegicus	21-29
287079-4	1979	In brown adipocytes, the Ca2+ ionophore A23187 and the Na+ ionophore monensin increase respiration if substrate is added, and incubation in a low-Na+ buffer decreases norepinephrine-induced respiration.	Norepinephrine	167-181	carbonic anhydrase 2	Homo sapiens	25-28
232613-0	1979	Effect on renal function and renin secretion of noradrenaline infused into the renal artery.	Norepinephrine	48-61	renin	Canis lupus familiaris	29-34
232613-3	1979	Noradrenaline infusion resulted in a significant elevation of renin secretion associated with marked vasoconstriction.	Norepinephrine	0-13	renin	Canis lupus familiaris	62-67
232613-6	1979	The simultaneous infusion of noradrenaline enhanced renin release without affecting renal haemodynamics or reducing Na-excretion.	Norepinephrine	29-42	renin	Canis lupus familiaris	52-57
375113-4	1979	Renal kallikrein is released by high arterial pressure, vasodilators, low doses of noradrenaline, angiotensin II, mineralocorticoids and rapid volume expansion.	Norepinephrine	83-96	kallikrein related peptidase 4	Homo sapiens	6-16
106542-1	1979	Effects of biogenic amines--noradrenaline and serotonin--on phosphorylase, acid alpha-glucosidase (gamma-amilase), glycogen synthetase as well as on content of glycogen in rat liver tissue, heart and skeletal muscles were studied in vivo.	Norepinephrine	28-41	alpha glucosidase	Rattus norvegicus	75-97
106542-3	1979	Noradrenaline, administered into rats, caused a decrease in activity of acid alpha-glucosidase in heart and liver tissues and did not affect the enzymatic activity in skeletal muscles.	Norepinephrine	0-13	alpha glucosidase	Rattus norvegicus	72-94
713169-0	1978	[Studies on hypertension: I) The effects of angiotensin II and norepinephrine infusion on renal hemodynamics and renin angiotensin system in anesthetized dogs.	Norepinephrine	63-77	renin	Canis lupus familiaris	113-118
212018-8	1978	Adenosine deaminase corrected the differences in response to noradrenaline and glucagon resulting from adrenalectomy.	Norepinephrine	61-74	adenosine deaminase	Rattus norvegicus	0-19
212018-10	1978	In the presence of adenosine deaminase rates of lipolysis, after stimulation by high concentrations of noradrenaline, glucagon, corticotropin or theophylline, were the same in cells from adrenalectomized or sham-operated rats.	Norepinephrine	103-116	adenosine deaminase	Rattus norvegicus	19-38
672009-1	1978	The effect of a single insulin injection on the reaction of the coronary vessels to adrenaline, noradrenaline, and acetylcholine was studied in experiments on dogs.	Norepinephrine	96-109	insulin	Canis lupus familiaris	23-30
672009-2	1978	Insulin induces a decrease of arterial pressure and of the resistance of the coronary and peripheral vessels reduces the reflex cholinergic and beta-adrenergic reactions of dilatation of the coronary vessels, and promotes alpha-adrenergic reactions in intracoronary administration of adrenaline and noradrenaline.	Norepinephrine	299-312	insulin	Canis lupus familiaris	0-7
206750-5	1978	Met- and leu-enkephalin (10(-7)-10(-5) M) decreased the high potassium induced [3H]-norepinephrine release from vas deferens, while substance P (10(-6) M) significantly increased it.	Norepinephrine	84-98	prodynorphin	Mus musculus	9-23
578406-3	1977	Daily exposure to 4.0 mg/l CS2 (first exposure 24 h after the first phenobarbitone injection) for 4 h prevented the decline in susceptibility on the 3rd and 4th days after phenobarbitone, when the reaction of unexposed rats to noradrenaline returned to normal.	Norepinephrine	227-240	calsyntenin 2	Rattus norvegicus	27-30
193126-0	1977	Action of tonin on the response of rat on mesenteric vessels to norepinephrine.	Norepinephrine	64-78	kallikrein 1-related peptidase C2	Rattus norvegicus	10-15
192922-4	1977	Intrarenal arterial infusion of norepinephrine at a control pressure increased a renin secretion.	Norepinephrine	32-46	renin	Canis lupus familiaris	81-86
192922-5	1977	However, norepinephrine infusion at a reduced pressure suppressed the renin release with a recovery of the vascular resistance to the control level.	Norepinephrine	9-23	renin	Canis lupus familiaris	70-75
966375-5	1976	Intrarenal arterial infusion of norepinephrine at a control pressure increased a renin release.	Norepinephrine	32-46	renin	Canis lupus familiaris	81-86
966375-6	1976	However, norepinephrine infusion at reduced pressure suppressed the renin release with recovery a vascular resistance to the control level.	Norepinephrine	9-23	renin	Canis lupus familiaris	68-73
1276544-12	1976	8 A large dose of insulin, 10 iu, transiently reduced HAVR and caused a weak and very transient inhibition of the effect of test doses of noradrenaline.	Norepinephrine	138-151	insulin	Canis lupus familiaris	18-25
24271344-3	1976	We found that PDEA can be released from brain particulate fraction by 1 muM norepinephrine, dopamine, adenosine, and histamine in the presence of ATP and a purified cAMP-dependent protein kinase; in similar conditions, serotonin is ineffective in concentrations up to 0.1 mM.	Norepinephrine	76-90	phosphodiesterase 6A	Homo sapiens	14-18
24271344-4	1976	Norepinephrine and dopamine activate the adenylate cyclase activity of those preparations from which they release the PDEA.	Norepinephrine	0-14	phosphodiesterase 6A	Homo sapiens	118-122
24271344-5	1976	Norepinephrine is more potent than dopamine in releasing PDEA from the particulate fraction of cerebellum, whereas dopamine is more active than norepinephrine in releasing PDEA from the particulate fraction of striatum.	Norepinephrine	0-14	phosphodiesterase 6A	Homo sapiens	57-61
24271344-5	1976	Norepinephrine is more potent than dopamine in releasing PDEA from the particulate fraction of cerebellum, whereas dopamine is more active than norepinephrine in releasing PDEA from the particulate fraction of striatum.	Norepinephrine	144-158	phosphodiesterase 6A	Homo sapiens	172-176
1208233-0	1975	The activation of the renin--angiotensin system in the dog after injection of noradrenaline into the lateral brain ventricle.	Norepinephrine	78-91	renin	Canis lupus familiaris	22-27
1115240-7	1975	In additional experiments in which the plasma renin level was measured, the potentiation of responses to sympathetic stimulation and a high dose of norepinephrine (2 mug) occurred at the time that the renin level was increased by hemorrhage.	Norepinephrine	148-162	renin	Canis lupus familiaris	46-51
1115240-7	1975	In additional experiments in which the plasma renin level was measured, the potentiation of responses to sympathetic stimulation and a high dose of norepinephrine (2 mug) occurred at the time that the renin level was increased by hemorrhage.	Norepinephrine	148-162	renin	Canis lupus familiaris	201-206
164437-2	1975	Adenosine deaminase markedly potentiated cyclic AMP accumulation due to norepinephrine.	Norepinephrine	72-86	adenosine deaminase	Rattus norvegicus	0-19
164437-14	1975	However, the addition of adenosine deaminase to fat cells incubated with 1.5 muM norepinephrine abolished the antilipolytic action of insulin and markedly reduced the increase in glucose oxidation due to insulin.	Norepinephrine	81-95	adenosine deaminase	Rattus norvegicus	25-44
1096294-0	1975	Effect of circulating norepinephrine on the renin release from the denervated kidney.	Norepinephrine	22-36	renin	Canis lupus familiaris	44-49
1096294-1	1975	The effect of renal denervation on the reactivity of the renin release mechanism to circulating norepinephrine was studied in six dogs with renal autografts.	Norepinephrine	96-110	renin	Canis lupus familiaris	57-62
1096294-3	1975	Both kidneys showed an increased release of renin when norepinephrine was given.	Norepinephrine	55-69	renin	Canis lupus familiaris	44-49
1096294-5	1975	Propranolol blocked the release of renin induced by norepinephrine without affecting either the reduced blood flow thorugh the autograft or the elevated blood pressure.	Norepinephrine	52-66	renin	Canis lupus familiaris	35-40
1096294-7	1975	The findings indicate that the renin release induced by circulating norepinephrine is independent of the intrarenal adrenergic nerves, and rather suggest that it is the result of an action of norepinephrine directly on the renin-producing juxtaglomerular cells.	Norepinephrine	68-82	renin	Canis lupus familiaris	31-36
1096294-7	1975	The findings indicate that the renin release induced by circulating norepinephrine is independent of the intrarenal adrenergic nerves, and rather suggest that it is the result of an action of norepinephrine directly on the renin-producing juxtaglomerular cells.	Norepinephrine	192-206	renin	Canis lupus familiaris	31-36
1096294-7	1975	The findings indicate that the renin release induced by circulating norepinephrine is independent of the intrarenal adrenergic nerves, and rather suggest that it is the result of an action of norepinephrine directly on the renin-producing juxtaglomerular cells.	Norepinephrine	192-206	renin	Canis lupus familiaris	223-228
4727451-5	1973	Release of insulin was strongly inhibited after epinephrine and norepinephrine, and strongly stimulated after isoproterenol.	Norepinephrine	64-78	insulin	Canis lupus familiaris	11-18
4727451-7	1973	Secretion of insulin remained unchanged after epinephrine and norepinephrine, but was stimulated by isoproterenol.	Norepinephrine	62-76	insulin	Canis lupus familiaris	13-20
4746448-0	1973	Influence of orphenadrine HC1 and its N-demethylated derivatives on the in vitro uptake of noradrenaline and 5-hydroxytryptamine by rat brain slices.	Norepinephrine	91-104	Hypercalciuria QTL 1	Rattus norvegicus	26-29
4403383-5	1972	Plasma cyclic GMP rose in response to infusions of alpha-adrenergic agents, viz., epinephrine or norepinephrine infused together with the beta-blocking agent, propranolol.	Norepinephrine	97-111	5'-nucleotidase, cytosolic II	Homo sapiens	14-17
5256232-0	1969	Stimulation of C14-melatonin synthesis from C14-tryptophan by noradrenaline in rat pineal in organ culture.	Norepinephrine	62-75	anti-Mullerian hormone receptor type 2	Rattus norvegicus	15-18
5256232-0	1969	Stimulation of C14-melatonin synthesis from C14-tryptophan by noradrenaline in rat pineal in organ culture.	Norepinephrine	62-75	anti-Mullerian hormone receptor type 2	Rattus norvegicus	44-47
13795313-1	1959	Pyrogallol inhibits the Omethylation of epinephrine and norepinephrine by catechol-O-methyl transferase in vitro as well as the metabolism of these catecholamines, and the formation of their O-methylated metabolites, in the intact mouse.	Norepinephrine	56-70	catechol-O-methyltransferase	Mus musculus	74-103
13030793-0	1953	Effect of tyrosinase upon the fluorimetric determination of epinephrine and arterenol.	Norepinephrine	76-85	tyrosinase	Homo sapiens	10-20
34053940-5	2021	A docking simulation using a triple reuptake inhibitor 8k and a serotonin/norepinephrine reuptake inhibitor 7j showed that the regions spanning transmembrane domain (TM)1, TM3, and TM6 form the ligand binding pocket.	Norepinephrine	74-88	tropomyosin 3	Homo sapiens	172-175
33988526-2	2021	While norepinephrine is usually delivered at a concentration of 16 to 32 mug/mL, out of concern for extravasation and interstitial necrosis, some patients receive more dilute norepinephrine solutions through peripheral intravenous catheters.	Norepinephrine	6-20	thrombopoietin	Mus musculus	77-79
33988526-3	2021	We describe a case of severe hyponatremia and seizure resulting from administration of norepinephrine concentrated at 4 mug/mL in dextrose 5% in water.	Norepinephrine	87-101	thrombopoietin	Mus musculus	124-126
33895869-5	2021	The exclusion of norepinephrine (NE) from synaptic vesicles leads to its oxidation into the toxic metabolite 3,4-dihydroxyphenyl glycolaldehyde (DOPEGAL), which subsequently activates cleavage of Tau at N368 by asparagine endopeptidase (AEP) and triggers LC neurodegeneration.	Norepinephrine	17-31	legumain	Homo sapiens	211-235
33895869-5	2021	The exclusion of norepinephrine (NE) from synaptic vesicles leads to its oxidation into the toxic metabolite 3,4-dihydroxyphenyl glycolaldehyde (DOPEGAL), which subsequently activates cleavage of Tau at N368 by asparagine endopeptidase (AEP) and triggers LC neurodegeneration.	Norepinephrine	17-31	legumain	Homo sapiens	237-240
33915109-4	2021	Intravital two-photon imaging after injection of noradrenaline revealed transient inhibition of CD8+ and CD4+ T cell locomotion in tissues.	Norepinephrine	49-62	CD8a molecule	Homo sapiens	96-99
33871822-7	2021	We further showed that the catecholaminergic neurotransmitter norepinephrine exerted a pro-inflammatory function by enhancing the expression of IL-17 cytokines.	Norepinephrine	62-76	interleukin 17A	Homo sapiens	144-149
33917814-5	2021	Results showed increased hippocampal ROS and NOX2 levels, serotonin turnover, kynurenine, and noradrenaline contents in Abeta-treated rats.	Norepinephrine	94-107	amyloid beta precursor protein	Rattus norvegicus	120-125
33515535-0	2021	Norepinephrine inhibits migration and invasion of human glioblastoma cell cultures possibly via MMP-11 inhibition.	Norepinephrine	0-14	matrix metallopeptidase 11	Homo sapiens	96-102
33515535-9	2021	Human Tumor Metastasis RT2 Profiler PCR Array assay showed that matrix metallopeptidase-11 (MMP-11) was decreased following norepinephrine treatment.	Norepinephrine	124-138	matrix metallopeptidase 11	Homo sapiens	64-90
33515535-9	2021	Human Tumor Metastasis RT2 Profiler PCR Array assay showed that matrix metallopeptidase-11 (MMP-11) was decreased following norepinephrine treatment.	Norepinephrine	124-138	matrix metallopeptidase 11	Homo sapiens	92-98
33451866-9	2021	The proportions of postoperative norepinephrine demand of patients carrying the AA genotype of ADRB2 rs1042713 (P = 0.016) and the AG genotype of COMT rs4680 (P = 0.018) were low.	Norepinephrine	33-47	adrenoceptor beta 2	Homo sapiens	95-100
32956676-6	2021	The present studies focused on the initial characterization of a novel atypical DAT inhibitor, CT-005404, which binds to DAT with high selectivity relative to serotonin and norepinephrine transport, and produces long-term elevations of extracellular DA.	Norepinephrine	173-187	solute carrier family 6 member 3	Homo sapiens	80-83
33551812-2	2020	Many of these are inhibitors of the presynaptic noradrenaline, dopamine, and serotonin transporters (NET, DAT, and SERT).	Norepinephrine	48-61	solute carrier family 6 member 3	Homo sapiens	106-109
33430014-10	2021	Furthermore, Ang-(1-7) applied centrally restored mean arterial blood pressure (MABP) without affecting heart rate (HR) and prevented vascular hyporesponsiveness to norepinephrine (NE) and AVP in animals that received LPS.	Norepinephrine	165-179	angiogenin	Rattus norvegicus	13-21
33437747-2	2020	Epinephrine and norepinephrine are stress hormones which affect many cells, including immune cells through interaction with adrenergic receptors, mainly beta2-adrenergic receptor.	Norepinephrine	16-30	adrenoceptor beta 2	Homo sapiens	153-178
32684737-19	2020	CONCLUSION: The inhibition of SGLT2 reduces the intermediate metabolite succinate, increases SCFA butyric acid levels and reduces norepinephrine content in mouse models of T1D.	Norepinephrine	130-144	solute carrier family 5 (sodium/glucose cotransporter), member 2	Mus musculus	30-35
32152116-5	2020	Interestingly, CD300f-/- mice displayed several characteristic MDD traits such as augmented microglial numbers, increased interleukin 6 and interleukin 1 receptor antagonist messenger RNA, alterations in synaptic strength, and noradrenaline-dependent and persistent depressive-like and anhedonic behaviors in females.	Norepinephrine	227-240	CD300 molecule like family member f	Homo sapiens	15-21
31818916-7	2020	In rodent brain, the compound time- and dose-dependently bound to MAGL, indirectly led to CB1 occupancy by raising 2-AG levels, and raised norepinephrine levels in cortex.	Norepinephrine	139-153	monoglyceride lipase	Homo sapiens	66-70
11152280-2	2000	Cleavage of syntaxin and SNAP-25 by BoNT/C1 decreased in a dose-dependent way the release of both noradrenaline and adrenaline, but noradrenaline release was more sensitive to BoNT/C1.	Norepinephrine	98-111	synaptosome associated protein 25	Bos taurus	25-32
11152280-2	2000	Cleavage of syntaxin and SNAP-25 by BoNT/C1 decreased in a dose-dependent way the release of both noradrenaline and adrenaline, but noradrenaline release was more sensitive to BoNT/C1.	Norepinephrine	132-145	synaptosome associated protein 25	Bos taurus	25-32
11152280-3	2000	Cleavage of SNAP-25 by BoNT/A also had a larger inhibitory effect on noradrenaline release than on adrenaline release.	Norepinephrine	69-82	synaptosome associated protein 25	Bos taurus	12-19
11003990-4	2000	When PBMC were stimulated with 10(-8)M norepinephrine in vitro, the expression of these adhesion molecules on CD3(-)CD56(+) NK cells was downmodulated within 30 min.	Norepinephrine	39-53	CD3 antigen, epsilon polypeptide	Mus musculus	110-113
11033234-5	2000	ACTH plasma levels were significantly associated with norepinephrine (NE) concentrations in the medulla and pons, but not with hypothalamic NE levels.	Norepinephrine	54-68	pro-opiomelanocortin-alpha	Mus musculus	0-4
10997600-2	2000	Both serotonin, acting through 5HT1B/2C receptors, and norepinephrine acting through beta2 and/or beta3 receptors reduce food intake and augment sympathetic activity.	Norepinephrine	55-69	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	85-90
11193002-4	2000	The selective alpha1D-adrenoceptor agonist, noradrenaline, elicited concentration-dependent contractions in all arterial rings from both species.	Norepinephrine	44-57	adrenoceptor alpha 1D	Rattus norvegicus	14-34
10835639-7	2000	We show that Th and Dbh deficiencies lead to reduced noradrenaline in the SNS, and that noradrenaline deficiency is a proximal cause of death in mutants by feeding catechol intermediates to pregnant dams, thereby partially averting Gata3 mutation-induced lethality.	Norepinephrine	53-66	tyrosine hydroxylase	Mus musculus	13-15
10827134-9	2000	Surprisingly, norepinephrine activates p38-MAPK via beta-ARs in mouse cardiomyocytes, but beta-AR activation of p38-MAPK alone is not sufficient to induce cardiomyocyte hypertrophy.	Norepinephrine	14-28	mitogen-activated protein kinase 14	Mus musculus	39-42
10801302-4	2000	Plasma catecholamine concentrations significantly increased at 60 min after intracerebroventricular injection of leptin (control vs. 60 min; epinephrine: 33 +/- 12 vs. 97 +/- 27 pg/ml, P &lt; 0.05; norepinephrine: 298 +/- 39 vs. 503 +/- 86 pg/ml, P &lt; 0.05).	Norepinephrine	198-212	leptin	Oryctolagus cuniculus	113-119
10719089-2	2000	We examined by immunohistochemistry the effects of monoamine oxidase (MAO) inhibition on the content of dopamine (DA) and noradrenaline (NA) in locus coeruleus (LC) neurons of the rat.	Norepinephrine	122-135	monoamine oxidase A	Rattus norvegicus	51-68
10719089-2	2000	We examined by immunohistochemistry the effects of monoamine oxidase (MAO) inhibition on the content of dopamine (DA) and noradrenaline (NA) in locus coeruleus (LC) neurons of the rat.	Norepinephrine	122-135	monoamine oxidase A	Rattus norvegicus	70-73
10718914-4	2000	In addition, we examined the effects of chronic central noradrenaline depletion upon GH secretagogue-induced activation of the arcuate nucleus.	Norepinephrine	56-69	gonadotropin releasing hormone receptor	Rattus norvegicus	85-87
10688962-9	2000	Collectively, the present findings allow us to conclude that cerebellin 1) directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and 2) indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release.	Norepinephrine	95-109	cerebellin 1 precursor	Rattus norvegicus	61-73
10789691-13	2000	The data strongly suggest that AT1 receptors are involved in this interaction, since selective AT1 receptor blockade with losartan significantly reduced the angiotensin II induced norepinephrine concentration.	Norepinephrine	180-194	angiotensin II receptor, type 1a	Rattus norvegicus	31-34
10789691-13	2000	The data strongly suggest that AT1 receptors are involved in this interaction, since selective AT1 receptor blockade with losartan significantly reduced the angiotensin II induced norepinephrine concentration.	Norepinephrine	180-194	angiotensin II receptor, type 1a	Rattus norvegicus	95-98
10629458-8	2000	A small decrease in IFN-gamma production and an increase in IL-10, IL-4, and IL-5 production were also observed with norepinephrine.	Norepinephrine	117-131	interleukin 5	Homo sapiens	77-81
10651151-7	2000	In conclusion, the present data suggest that the postganglionic sympathetic nerve fibers innervating the resistance vessels of the rat are endowed with prejunctional ORL1 receptors, activation of which causes inhibition of noradrenaline release.	Norepinephrine	223-236	opioid related nociceptin receptor 1	Rattus norvegicus	166-170
10581494-4	1999	The Catechol-O-Methyltransferase (COMT) gene is an interesting candidate for ADHD as it is involved in the breakdown of dopamine and norepinephrine, neurotransmitters strongly implicated in the etiology of ADHD.	Norepinephrine	133-147	catechol-O-methyltransferase	Homo sapiens	4-32
10581494-4	1999	The Catechol-O-Methyltransferase (COMT) gene is an interesting candidate for ADHD as it is involved in the breakdown of dopamine and norepinephrine, neurotransmitters strongly implicated in the etiology of ADHD.	Norepinephrine	133-147	catechol-O-methyltransferase	Homo sapiens	34-38
10644007-3	1999	Here we show that MIF is able to catalyze the conversion of dopaminechrome and norepinephrinechrome, toxic quinone products of the neurotransmitters dopamine and norepinephrine, respectively, to indole derivatives that may serve as precursors to neuromelanin.	Norepinephrine	79-93	macrophage migration inhibitory factor	Homo sapiens	18-21
10490706-7	1999	It should be noted that the association between the high-enzyme activity COMT val allele that increases CNS dopamine (and norepinephrine) clearance is consistent with the use of methylphenidate, an agent that increases dopamine (and norepinephrine) turnover, in the treatment of this disorder.	Norepinephrine	122-136	catechol-O-methyltransferase	Homo sapiens	73-77
10490706-7	1999	It should be noted that the association between the high-enzyme activity COMT val allele that increases CNS dopamine (and norepinephrine) clearance is consistent with the use of methylphenidate, an agent that increases dopamine (and norepinephrine) turnover, in the treatment of this disorder.	Norepinephrine	233-247	catechol-O-methyltransferase	Homo sapiens	73-77
10555559-5	1999	Treatment of mouse brown adipocytes in primary culture with noradrenaline also triggered a dose-dependent increase of the levels of UCP1 mRNA and UCP2 mRNA.	Norepinephrine	60-73	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	132-136
10484544-3	1999	METHODS AND RESULTS: Rats infused with norepinephrine or Ang II for 6 days developed similar hypertensive responses, but only Ang II-treated rats exhibited significant increases in aortic VCAM-1 protein and mRNA expression.	Norepinephrine	39-53	vascular cell adhesion molecule 1	Rattus norvegicus	188-194
10499371-1	1999	The regulation of extracellular noradrenaline levels in the cingulate cortex by somatodendritic alpha2-adrenoceptors located in the locus coeruleus was evaluated in the rat by using dual-probe microdialysis.	Norepinephrine	32-45	adrenoceptor alpha 2A	Rattus norvegicus	96-116
10424772-0	1999	Aldose reductase, a key enzyme in the oxidative deamination of norepinephrine in rats.	Norepinephrine	63-77	aldo-keto reductase family 1 member B1	Rattus norvegicus	0-16
10419546-5	1999	The dose-dependent inductions of ICER protein by norepinephrine, the beta(1)-adrenergic receptor agonist isoproterenol, vasoactive intestinal peptide, pituitary adenylate cyclase-activating polypeptide, and adenosine are correlated to regulatory dynamics in melatonin production.	Norepinephrine	49-63	cAMP responsive element modulator	Rattus norvegicus	33-37
10419546-5	1999	The dose-dependent inductions of ICER protein by norepinephrine, the beta(1)-adrenergic receptor agonist isoproterenol, vasoactive intestinal peptide, pituitary adenylate cyclase-activating polypeptide, and adenosine are correlated to regulatory dynamics in melatonin production.	Norepinephrine	49-63	adenylate cyclase activating polypeptide 1	Rattus norvegicus	151-201
10385385-5	1999	Norepinephrine elicits a potent stimulatory effect on M-D1 messenger RNA and enzyme activities, whereas PRL only increases M-D 1 activity and may modulate the enzyme response to norepinephrine.	Norepinephrine	0-14	MAFD1	Homo sapiens	54-58
10344349-1	1999	BACKGROUND: Pregnant rats with adriamycin nephropathy (ADRP rats) develop hypertension and have an increased vascular reactivity to noradrenaline in the isolated mesenteric bed in vitro.	Norepinephrine	132-145	perilipin 2	Rattus norvegicus	55-59
10435003-7	1999	Noradrenaline (NA, 1 microM) was used to stimulate beta 1-AR and isoprenaline (ISO, 1 microM) in the presence of the beta 1-AR antagonist CGP 20712A (0.1 microM) to stimulate beta 2-AR.	Norepinephrine	0-13	adrenoceptor beta 1	Homo sapiens	51-60
10435003-7	1999	Noradrenaline (NA, 1 microM) was used to stimulate beta 1-AR and isoprenaline (ISO, 1 microM) in the presence of the beta 1-AR antagonist CGP 20712A (0.1 microM) to stimulate beta 2-AR.	Norepinephrine	0-13	adrenoceptor beta 1	Homo sapiens	117-126
10218872-1	1999	Recent studies indicate that 5-HT1A receptor agonists stimulate noradrenaline release in the brain.	Norepinephrine	64-77	5-hydroxytryptamine receptor 1A	Rattus norvegicus	29-35
10218872-2	1999	Here we investigate the mechanism underlying the increase in extracellular noradrenaline induced by (+/-)-MDL 73005EF, a weak 5-HT1A receptor agonist.	Norepinephrine	75-88	5-hydroxytryptamine receptor 1A	Rattus norvegicus	126-132
10218872-12	1999	In conclusion, our data suggest that (+/-)-MDL 73005EF increases noradrenaline release in rat hippocampus through activation of 5HT1A receptors that appear to be located postsynaptically.	Norepinephrine	65-78	5-hydroxytryptamine receptor 1A	Rattus norvegicus	128-133
9933504-7	1999	While CRH, norepinephrine, and epinephrine evoked significant increases in beta-endorphin release, lactate, in combination with these secretagogues did not alter their effects.	Norepinephrine	11-25	pro-opiomelanocortin-alpha	Mus musculus	75-89
9988104-11	1999	These results also suggest that PACAP-27 produces tachycardia by directly releasing norepinephrine from cardiac sympathetic nerve terminals rather than by direct or baroreceptor reflex-mediated increases in sympathetic nerve activity.	Norepinephrine	84-98	adenylate cyclase activating polypeptide 1	Rattus norvegicus	32-37
9988105-15	1999	The increased responsiveness to norepinephrine may involve (i) a rapid up-regulation of cardiac beta1-adrenoceptors and cAMP signaling in cardiac pacemaker cells due to the loss of the inhibitory influence of cardiac NO, and (ii) the up-regulation of beta1-adrenoceptor-mediated signal transduction processes in response to the L-NAME-induced withdrawal of cardiac sympathetic nerve activity.	Norepinephrine	32-46	adrenoceptor beta 1	Homo sapiens	96-114
9884381-10	1999	CONCLUSIONS: Norepinephrine and epinephrine hasten human ventricular relaxation and promote phosphorylation of implicated proteins through both beta1- and beta2-adrenergic receptors, thereby potentially improving diastolic function.	Norepinephrine	13-27	adrenoceptor beta 1	Homo sapiens	144-181
10573779-3	1999	There is an ongoing thoracolumbar sympathetic outflow to the lower urinary tract during filling, and noradrenaline, released from adrenergic nerves and acting through stimulation of beta-adrenoceptors (beta 2 and beta 3), may relax the bladder, due to a relative dominance of beta- over alpha-adrenoceptors in the detrusor.	Norepinephrine	101-114	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	202-219
9838121-0	1998	Monoamine oxidase activity in noradrenaline neurons of the locus coeruleus of the rat.	Norepinephrine	30-43	monoamine oxidase A	Rattus norvegicus	0-17
9879729-0	1998	ORL1 receptor-mediated inhibition by nociceptin of noradrenaline release from perivascular sympathetic nerve endings of the rat tail artery.	Norepinephrine	51-64	opioid related nociceptin receptor 1	Rattus norvegicus	0-4
9781735-9	1998	In septic patients, norepinephrine seems to increase pHi.	Norepinephrine	20-34	glucose-6-phosphate isomerase	Homo sapiens	53-56
9751781-7	1998	Norepinephrine inhibited wt and beta3-/- neurons similarly but the voltage sensitive component was greater for N-type than P/Q-type Ca2+ channels.	Norepinephrine	0-14	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	32-40
9712661-0	1998	Plasma membrane transporters of serotonin, dopamine, and norepinephrine mediate serotonin accumulation in atypical locations in the developing brain of monoamine oxidase A knock-outs.	Norepinephrine	57-71	monoamine oxidase A	Mus musculus	152-171
9712709-1	1998	Phenylethanolamine N-methyltransferase (PNMT) catalyzes the production of epinephrine from norepinephrine using S-adenosyl-L-methionine as a methyl donor.	Norepinephrine	91-105	phenylethanolamine N-methyltransferase	Homo sapiens	0-38
9712709-1	1998	Phenylethanolamine N-methyltransferase (PNMT) catalyzes the production of epinephrine from norepinephrine using S-adenosyl-L-methionine as a methyl donor.	Norepinephrine	91-105	phenylethanolamine N-methyltransferase	Homo sapiens	40-44
9707197-9	1998	The increase of noradrenaline may promote the secretion of BNP.	Norepinephrine	16-29	natriuretic peptide B	Homo sapiens	59-62
9754635-5	1998	Intraperitoneal injections of various doses (0.2-2 mg kg(-1)) of noradrenaline and adrenaline dose-dependently induced hepatic c-fos and c-jun mRNA levels.	Norepinephrine	65-78	jun proto-oncogene	Mus musculus	137-142
9754635-6	1998	The time-course study showed that there was an increase in c-fos and c-jun mRNA levels within 15 min, which reached a peak at 30 min, and returned to the basal levels 1-2 h after noradrenaline or adrenaline injection (2 mg kg(-1), i.p.).	Norepinephrine	179-192	jun proto-oncogene	Mus musculus	69-74
9754635-7	1998	A Western blot assay revealed that c-Jun protein levels were maximally increased at 30 min and 1-2 h in noradrenaline- and adrenaline-treated mice, respectively.	Norepinephrine	104-117	jun proto-oncogene	Mus musculus	35-40
9754635-23	1998	The results suggest that noradrenaline elicits the hepatic c-fos and c-jun mRNA responses by stimulating alpha1-adrenergic receptors, whereas in the case of adrenaline, this is elicited by stimulating both alpha1- and beta2-adrenergic receptors in mice.	Norepinephrine	25-38	jun proto-oncogene	Mus musculus	69-74
9518674-1	1998	3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the monoamine oxidase A metabolite of norepinephrine (NE) and epinephrine.	Norepinephrine	85-99	monoamine oxidase A	Rattus norvegicus	51-70
9517384-8	1998	The contractile response to noradrenaline was unaltered by irradiation throughout the experimental period, but in contrast to control vessels, an increase in the sensitivity to noradrenaline in the presence of the nitric oxide synthase (NOS) inhibitor N(G)-nitro-L-arginine was not observed in the irradiated vessels.	Norepinephrine	28-41	nitric oxide synthase, brain	Oryctolagus cuniculus	214-235
9517384-8	1998	The contractile response to noradrenaline was unaltered by irradiation throughout the experimental period, but in contrast to control vessels, an increase in the sensitivity to noradrenaline in the presence of the nitric oxide synthase (NOS) inhibitor N(G)-nitro-L-arginine was not observed in the irradiated vessels.	Norepinephrine	177-190	nitric oxide synthase, brain	Oryctolagus cuniculus	214-235
9489993-7	1998	Interestingly, the ability of norepinephrine to increase intracellular calcium concentration was not altered by pretreatment of the cells with bradykinin, i.e. bradykinin induced alpha1b-adrenoceptor phosphorylation but this did not lead to receptor desensitization.	Norepinephrine	30-44	adrenoceptor alpha 1B	Rattus norvegicus	179-199
9833158-2	1998	Consequently, the inhibition of the converting enzyme by ACE inhibitors resulting in a lower concentration of angiotensin II or blockade of the specific AT1 receptors by AT1 receptor blocking agents should lead to a decrease in both noradrenaline and adrenaline release.	Norepinephrine	233-246	angiotensin II receptor, type 1a	Rattus norvegicus	153-156
9833158-2	1998	Consequently, the inhibition of the converting enzyme by ACE inhibitors resulting in a lower concentration of angiotensin II or blockade of the specific AT1 receptors by AT1 receptor blocking agents should lead to a decrease in both noradrenaline and adrenaline release.	Norepinephrine	233-246	angiotensin II receptor, type 1a	Rattus norvegicus	170-173
9833158-3	1998	It has been demonstrated that ACE inhibition did not influence the net catecholamine overflow during stimulation of the sympathetic nerves in contrast to AT1 antagonists which can specifically and dose dependently diminish noradrenaline and adrenaline release, an effect that could be explained by a compensating mechanism of bradykinin.	Norepinephrine	223-236	angiotensin II receptor, type 1a	Rattus norvegicus	154-157
9833158-6	1998	As could be demonstrated with losartan and HR 720, candesartan lowered AT1 receptor mediated angiotensin II-induced noradrenaline release in a dose-dependent manner.	Norepinephrine	116-129	angiotensin II receptor, type 1a	Rattus norvegicus	71-74
9661134-2	1998	In the present study, the relevance of AT1-mediated noradrenaline and adrenaline release in a whole-animal model, which reflects the peripherally sympathetic system (pithed rat), was investigated.	Norepinephrine	52-65	angiotensin II receptor, type 1a	Rattus norvegicus	39-42
9585117-4	1998	The alpha1B-adrenoceptor subtype may be located on a space more proximal to the sympathetic nerve endings than the alpha1A-adrenoceptor subtype, because the positive inotropic effect of endogenous norepinephrine was mediated entirely by the alpha1B-adrenoceptor subtype.	Norepinephrine	197-211	adrenoceptor alpha 1A	Homo sapiens	115-135
9398725-13	1997	ET-1 was 2.5-fold more potent than noradrenaline in eliciting contraction of ovarian artery, acting through the ETA receptor.	Norepinephrine	35-48	endothelin receptor type A	Homo sapiens	112-115
9386176-5	1997	Endothelin-1 (ET-1) and norepinephrine (NE) increased both OP and atrial natriuretic peptide (ANP) mRNA levels twofold to threefold (P&lt;.01).	Norepinephrine	24-38	secreted phosphoprotein 1	Rattus norvegicus	59-61
9652973-4	1997	Neuronal AT1 receptors are involved in norepinephrine (NE) neuromodulation.	Norepinephrine	39-53	angiotensin II receptor type 1	Homo sapiens	9-12
9341183-2	1997	Basal alpha1b-adrenoreceptor phosphorylation was markedly increased by endothelin-1, norepinephrine, and phorbol esters.	Norepinephrine	85-99	adrenoceptor alpha 1B	Rattus norvegicus	6-28
9337215-8	1997	Plasma norepinephrine and endothelin increased by more than fivefold with chronic pacing and remained elevated with AT1 Ang II blockade.	Norepinephrine	7-21	angiotensin II receptor type 1	Sus scrofa	116-119
9300318-1	1997	In this study we examined the effects of long-term treatment of 19 patients with primary hypertension with the beta 1-adrenoceptor antagonist atenolol on norepinephrine and epinephrine kinetics, at rest and during sympathoadrenal stimulation by lower body negative pressure.	Norepinephrine	154-168	adrenoceptor beta 1	Homo sapiens	111-130
9322222-4	1997	The hypothesized pathway is via norepinephrine-induced release of NO from NOergic neurons which activates LHRH release.	Norepinephrine	32-46	gonadotropin releasing hormone 1	Homo sapiens	106-110
9218503-2	1997	Although leptin increases norepinephrine turnover in thermogenic tissues, the effects of leptin on directly measured sympathetic nerve activity to thermogenic and other tissues are not known.	Norepinephrine	26-40	leptin	Rattus norvegicus	9-15
9237667-5	1997	In addition, on treatment with norepinephrine (NE), transcript level of H-FABP was elevated markedly but that of A-FABP was not changed in rat brown adipocytes.	Norepinephrine	31-45	fatty acid binding protein 3	Rattus norvegicus	72-78
9237667-5	1997	In addition, on treatment with norepinephrine (NE), transcript level of H-FABP was elevated markedly but that of A-FABP was not changed in rat brown adipocytes.	Norepinephrine	31-45	fatty acid binding protein 4	Rattus norvegicus	113-119
9237550-1	1997	3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the monoamine oxidase A metabolite of norepinephrine and epinephrine.	Norepinephrine	85-99	monoamine oxidase A	Rattus norvegicus	51-70
9278773-14	1997	We conclude that noradrenaline contracts rat interlobar arteries by an alpha(1)A-adrenoceptor; its co-transmitter, neuropeptide Y, affects the response only marginally in this vascular bed.	Norepinephrine	17-30	adrenoceptor alpha 1A	Rattus norvegicus	71-93
9166715-3	1997	In the presence of 40 microM H-89, mRNA levels of TH, DBH, and PNMT were reduced to 17 +/- 8, 19 +/- 8, and 14 +/- 2% of the untreated control, respectively, in 24 h, and intracellular norepinephrine and epinephrine levels were decreased to 20 and 34%, respectively, in 72 h. At 20 microM, although the basal enzyme gene expression levels were little affected, their induction by forskolin was abolished and norepinephrine and epinephrine levels fell to 55 and 74%.	Norepinephrine	185-199	tyrosine hydroxylase	Bos taurus	50-52
9166715-3	1997	In the presence of 40 microM H-89, mRNA levels of TH, DBH, and PNMT were reduced to 17 +/- 8, 19 +/- 8, and 14 +/- 2% of the untreated control, respectively, in 24 h, and intracellular norepinephrine and epinephrine levels were decreased to 20 and 34%, respectively, in 72 h. At 20 microM, although the basal enzyme gene expression levels were little affected, their induction by forskolin was abolished and norepinephrine and epinephrine levels fell to 55 and 74%.	Norepinephrine	185-199	phenylethanolamine N-methyltransferase	Bos taurus	63-67
9166715-3	1997	In the presence of 40 microM H-89, mRNA levels of TH, DBH, and PNMT were reduced to 17 +/- 8, 19 +/- 8, and 14 +/- 2% of the untreated control, respectively, in 24 h, and intracellular norepinephrine and epinephrine levels were decreased to 20 and 34%, respectively, in 72 h. At 20 microM, although the basal enzyme gene expression levels were little affected, their induction by forskolin was abolished and norepinephrine and epinephrine levels fell to 55 and 74%.	Norepinephrine	408-422	tyrosine hydroxylase	Bos taurus	50-52
9166715-3	1997	In the presence of 40 microM H-89, mRNA levels of TH, DBH, and PNMT were reduced to 17 +/- 8, 19 +/- 8, and 14 +/- 2% of the untreated control, respectively, in 24 h, and intracellular norepinephrine and epinephrine levels were decreased to 20 and 34%, respectively, in 72 h. At 20 microM, although the basal enzyme gene expression levels were little affected, their induction by forskolin was abolished and norepinephrine and epinephrine levels fell to 55 and 74%.	Norepinephrine	408-422	phenylethanolamine N-methyltransferase	Bos taurus	63-67
9205950-6	1997	Furthermore, both beta 1 and beta 2-adrenoceptors can mediate experimental arrhythmias in human cardiac preparations elicited by noradrenaline and adrenaline.	Norepinephrine	129-142	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	29-35
9159177-1	1997	Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex, hippocampus, and cerebellum, compared with normal wild-type mice.	Norepinephrine	92-106	monoamine oxidase A	Mus musculus	18-37
9159177-1	1997	Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex, hippocampus, and cerebellum, compared with normal wild-type mice.	Norepinephrine	92-106	monoamine oxidase A	Mus musculus	39-43
9159177-1	1997	Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex, hippocampus, and cerebellum, compared with normal wild-type mice.	Norepinephrine	136-150	monoamine oxidase A	Mus musculus	18-37
9159177-1	1997	Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex, hippocampus, and cerebellum, compared with normal wild-type mice.	Norepinephrine	136-150	monoamine oxidase A	Mus musculus	39-43
9084425-3	1997	The comigration of noradrenaline, secretogranin II, and dopamine-beta-hydroxylase on sucrose-D2O gradient fractions indicates the presence of a population of noradrenaline-containing large dense-cored vesicles (LDCVs).	Norepinephrine	158-171	secretogranin II	Homo sapiens	34-50
9054858-0	1997	Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both alpha 1- and beta-adrenoceptors.	Norepinephrine	0-14	Raf-1 proto-oncogene, serine/threonine kinase	Rattus norvegicus	27-32
9054858-2	1997	METHODS AND RESULTS: To elucidate the molecular mechanism of norepinephrine-induced hypertrophic responses, we examined the effects of protein kinase A and protein kinase C on the activities of raf-1 kinase and mitogen-activated protein (MAP) kinases and on protein synthesis rates using cultured cardiomyocytes of neonatal rats.	Norepinephrine	61-75	Raf-1 proto-oncogene, serine/threonine kinase	Rattus norvegicus	194-199
9054858-8	1997	CONCLUSIONS: Norepinephrine activates the raf-1 kinase/MAP kinase cascade through both alpha 1- and beta-adrenergic stimulation, and signaling pathways from the two receptors synergistically induce cardiomyocyte hypertrophy.	Norepinephrine	13-27	Raf-1 proto-oncogene, serine/threonine kinase	Rattus norvegicus	42-47
24394658-9	1997	Although the development of thromboxane-like constrictor response, after the inhibition of nitric oxide in hypertensive vessels, was unaffected by test diets, both TRF and GPO feeding prevented the amplification of this unwanted constriction by a threshold dose (7.2x10-10 M) of noradrenaline.	Norepinephrine	279-292	interleukin 5	Rattus norvegicus	164-167
9138687-0	1997	Pharmacological characterization of an alpha 1A-adrenoceptor mediating contractile responses to noradrenaline in isolated caudal artery of rat.	Norepinephrine	96-109	adrenoceptor alpha 1A	Rattus norvegicus	39-60
9048762-7	1997	The present data demonstrate that combined blockade of 5-HT1A and 5-HT1B autoreceptors markedly and selectively potentiates the fluoxetine-induced increase in dialysate levels of 5-HT versus DA and NAD in the FCx of freely moving rats.	Norepinephrine	198-201	5-hydroxytryptamine receptor 1A	Rattus norvegicus	55-72
9167626-4	1997	After 21 days, concentrations of norepinephrine and epinephrine were significantly increased in the group treated with nerve growth factor compared with those in the control group (211% norepinephrine and 322% epinephrine).	Norepinephrine	33-47	nerve growth factor	Rattus norvegicus	119-138
9167626-4	1997	After 21 days, concentrations of norepinephrine and epinephrine were significantly increased in the group treated with nerve growth factor compared with those in the control group (211% norepinephrine and 322% epinephrine).	Norepinephrine	186-200	nerve growth factor	Rattus norvegicus	119-138
9121699-1	1997	Catechol-O-methyltransferase (COMT) is an enzyme that inactivates catecholamines such as adrenaline, noradrenaline, dopamine, and levodopa.	Norepinephrine	101-114	catechol-O-methyltransferase	Homo sapiens	0-28
9121699-1	1997	Catechol-O-methyltransferase (COMT) is an enzyme that inactivates catecholamines such as adrenaline, noradrenaline, dopamine, and levodopa.	Norepinephrine	101-114	catechol-O-methyltransferase	Homo sapiens	30-34
9029240-3	1997	In addition, the strong affinity of CE for the catecholamine-deactivating enzyme catechol-O-methyltransferase (COMT) has led to speculations about their possible role in safeguarding norepinephrine from premature decomposition during exercise.	Norepinephrine	183-197	catechol-O-methyltransferase	Homo sapiens	81-109
9029240-3	1997	In addition, the strong affinity of CE for the catecholamine-deactivating enzyme catechol-O-methyltransferase (COMT) has led to speculations about their possible role in safeguarding norepinephrine from premature decomposition during exercise.	Norepinephrine	183-197	catechol-O-methyltransferase	Homo sapiens	111-115
9034207-6	1997	These findings suggest that the difference in norepinephrine-induced lipolysis between visceral and subcutaneous fat cells may be due to the differences in HSL activity and lipid droplet character at each site.	Norepinephrine	46-60	lipase E, hormone sensitive type	Rattus norvegicus	156-159
8969197-4	1996	Similarly, in brown fat cell cultures, norepinephrine addition led to down-regulation of beta3 gene expression, with a lag phase of 30 min and with an apparent half-life of beta3 mRNA of approximately 30 min.	Norepinephrine	39-53	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	89-94
8969197-4	1996	Similarly, in brown fat cell cultures, norepinephrine addition led to down-regulation of beta3 gene expression, with a lag phase of 30 min and with an apparent half-life of beta3 mRNA of approximately 30 min.	Norepinephrine	39-53	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	173-178
8969197-5	1996	This down-regulation was stimulated via the beta3 receptors themselves and mediated via cAMP; the apparent affinity of norepinephrine was extremely high (&lt;1 nM).	Norepinephrine	119-133	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	44-49
8930173-9	1996	Norepinephrine displayed, respectively, 18- and 31-fold selectivity for the high affinity state of the alpha-2C adrenoceptor as compared to alpha-2A- or alpha-2B adrenoceptors, and was &gt; 100,000- fold selective over platelet I1-imidazoline sites.	Norepinephrine	0-14	adrenoceptor alpha 2C	Homo sapiens	103-124
8900127-6	1996	The norepinephrine-stimulated GLUT4 translocation and glucose uptake via Gq may possibly contribute to the fuel supply required for thermogenesis in brown adipocytes and for the enhanced contractility in cardiomyocytes, both of which have an abundant endogenous GLUT4.	Norepinephrine	4-18	solute carrier family 2 member 4	Homo sapiens	30-35
8900127-6	1996	The norepinephrine-stimulated GLUT4 translocation and glucose uptake via Gq may possibly contribute to the fuel supply required for thermogenesis in brown adipocytes and for the enhanced contractility in cardiomyocytes, both of which have an abundant endogenous GLUT4.	Norepinephrine	4-18	solute carrier family 2 member 4	Homo sapiens	262-267
8853428-5	1996	Angiotensin II and norepinephrine reduced predominantly only CBF (-24 and -19%, respectively).	Norepinephrine	19-33	CCAAT/enhancer binding protein zeta	Rattus norvegicus	61-64
8756584-5	1996	Using the activation of lipolysis as an index of cAMP-dependent protein kinase activity, we show that inhibition of leptin release by norepinephrine or the selective beta 3-adrenergic receptor agonist, CL316,243, occurred in parallel to activation of cAMP-dependent protein kinase.	Norepinephrine	134-148	leptin	Rattus norvegicus	116-122
8878107-4	1996	NOR and PHE induced a stronger inhibition on the 3% NaCl intake induced by renin than on the intake induced by deoxycorticosterone (DOC), and CLO did the opposite.	Norepinephrine	0-3	renin	Rattus norvegicus	75-80
12114640-0	1996	Deficiency of Phenylethanolamine N-Methyltransferase in Norepinephrine-Producing Pheochromocytoma.	Norepinephrine	56-70	phenylethanolamine N-methyltransferase	Homo sapiens	14-52
8901462-9	1996	The G-6-PD mRNA was elevated by norepinephrine.	Norepinephrine	32-46	glucose-6-phosphate dehydrogenase	Rattus norvegicus	4-10
8813537-2	1996	A subpopulation of interneurons in layer III of the rat piriform cortex that are excited by 5-hydroxytryptamine (5-HT) via 5-HT2A receptors are also excited by norepinephrine via alpha 1-adrenoceptors.	Norepinephrine	160-174	5-hydroxytryptamine receptor 2A	Rattus norvegicus	123-129
8813537-4	1996	The pA2 values for the antagonist blockade of norepinephrine-mediated interneuron excitation were significantly correlated to literature values for the pKi values of antagonist binding to the alpha 1B-adrenoceptor (r = 0.919) and the cloned alpha 1b-adrenoceptor (r = 0.849) but were not correlated to the pKi values of antagonist binding to the alpha 1A-adrenoceptor or the cloned alpha 1a- and alpha 1d-adrenoceptor.	Norepinephrine	46-60	adrenoceptor alpha 1B	Rattus norvegicus	192-213
8813537-4	1996	The pA2 values for the antagonist blockade of norepinephrine-mediated interneuron excitation were significantly correlated to literature values for the pKi values of antagonist binding to the alpha 1B-adrenoceptor (r = 0.919) and the cloned alpha 1b-adrenoceptor (r = 0.849) but were not correlated to the pKi values of antagonist binding to the alpha 1A-adrenoceptor or the cloned alpha 1a- and alpha 1d-adrenoceptor.	Norepinephrine	46-60	adrenoceptor alpha 1B	Rattus norvegicus	241-262
8813537-4	1996	The pA2 values for the antagonist blockade of norepinephrine-mediated interneuron excitation were significantly correlated to literature values for the pKi values of antagonist binding to the alpha 1B-adrenoceptor (r = 0.919) and the cloned alpha 1b-adrenoceptor (r = 0.849) but were not correlated to the pKi values of antagonist binding to the alpha 1A-adrenoceptor or the cloned alpha 1a- and alpha 1d-adrenoceptor.	Norepinephrine	46-60	adrenoceptor alpha 1A	Rattus norvegicus	346-367
8813537-4	1996	The pA2 values for the antagonist blockade of norepinephrine-mediated interneuron excitation were significantly correlated to literature values for the pKi values of antagonist binding to the alpha 1B-adrenoceptor (r = 0.919) and the cloned alpha 1b-adrenoceptor (r = 0.849) but were not correlated to the pKi values of antagonist binding to the alpha 1A-adrenoceptor or the cloned alpha 1a- and alpha 1d-adrenoceptor.	Norepinephrine	46-60	adrenoceptor alpha 1A	Rattus norvegicus	382-417
8640984-12	1996	Bosentan attenuated norepinephrine-induced increases in ventricular weight, ratio of RNA to protein, and expression of skeletal alpha-actin mRNA and beta-myosin heavy chain mRNA at 5 days, but it did not attenuate increased ventricular expression of atrial natriuretic factor mRNA.	Norepinephrine	20-34	myosin heavy chain 7	Rattus norvegicus	149-172
8641736-3	1996	Norepinephrine causes a 66 percent decrease in Bmax of Ang II type 1 (AT1) receptors in neuronal cultures of WKY brain.	Norepinephrine	0-14	angiotensin II receptor, type 1a	Rattus norvegicus	55-68
8641736-3	1996	Norepinephrine causes a 66 percent decrease in Bmax of Ang II type 1 (AT1) receptors in neuronal cultures of WKY brain.	Norepinephrine	0-14	angiotensin II receptor, type 1a	Rattus norvegicus	70-73
8641736-4	1996	This decrease is mediated by the interaction of norepinephrine with the alpha1a-adrenergic receptor subtype.	Norepinephrine	48-62	adrenoceptor alpha 1D	Rattus norvegicus	72-99
8641736-5	1996	Norepinephrine also causes a decrease in mRNA levels for AT1 receptors.	Norepinephrine	0-14	angiotensin II receptor, type 1a	Rattus norvegicus	57-60
8641736-6	1996	A maximal decrease of 83 percent in AT1, receptor mRNA is observed in 8 hours with 100 micromol/L norepinephrine, is blocked by 5-methyluradipil, and involves inhibition of AT1 receptor transcription.	Norepinephrine	98-112	angiotensin II receptor, type 1a	Rattus norvegicus	36-39
8641736-9	1996	Thus, these data show that norepinephrine-mediated downregulation of AT1 receptors is associated with a parallel decrease in AT1 mRNA and Ang II stimulation of norepinephrine transporter mRNA and involves the alpha1a-adrenergic receptor in neurons of WKY brain.	Norepinephrine	27-41	angiotensin II receptor, type 1a	Rattus norvegicus	69-72
8641736-9	1996	Thus, these data show that norepinephrine-mediated downregulation of AT1 receptors is associated with a parallel decrease in AT1 mRNA and Ang II stimulation of norepinephrine transporter mRNA and involves the alpha1a-adrenergic receptor in neurons of WKY brain.	Norepinephrine	27-41	angiotensin II receptor, type 1a	Rattus norvegicus	125-128
8641736-9	1996	Thus, these data show that norepinephrine-mediated downregulation of AT1 receptors is associated with a parallel decrease in AT1 mRNA and Ang II stimulation of norepinephrine transporter mRNA and involves the alpha1a-adrenergic receptor in neurons of WKY brain.	Norepinephrine	27-41	adrenoceptor alpha 1D	Rattus norvegicus	209-236
8813375-1	1996	3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the monoamine oxidase A (MAO-A) metabolite of norepinephrine (NE) and epinephrine (Epi).	Norepinephrine	93-107	monoamine oxidase A	Rattus norvegicus	51-70
8813375-1	1996	3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the monoamine oxidase A (MAO-A) metabolite of norepinephrine (NE) and epinephrine (Epi).	Norepinephrine	93-107	monoamine oxidase A	Rattus norvegicus	72-77
8817480-8	1996	The noradrenaline enhancement of creatine accumulation at 48 h was inhibited by the mixed alpha- and beta-antagonist labetalol and by the beta-antagonist propranolol, but was unaffected by the alpha 2 antagonist phentolamine; greater inhibition was caused by the beta 2 antagonist butoxamine than the beta 1 antagonist atenolol.	Norepinephrine	4-17	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	263-269
8724036-0	1996	Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120.	Norepinephrine	54-67	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	123-128
8724036-6	1996	HIV-1 gp120 potentiated the NMDA (1 mM)-evoked [3H]-noradrenaline release (maximal effect approximately 110% at 1 nM).	Norepinephrine	52-65	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	6-11
8733596-22	1996	Thus, the non-selective ETA/ETB receptor antagonist, SB 209670, augments the degree of (i) hypotension, (ii) vascular hyporeactivity to noradrenaline, (iii) renal dysfunction and (iv) metabolic acidosis caused by endotoxin in the anaesthetized rat.	Norepinephrine	136-149	endothelin receptor type A	Rattus norvegicus	24-27
8635568-0	1996	Increased perivascular norepinephrine following intracerebroventricular infusion of NGF into adult rats.	Norepinephrine	23-37	nerve growth factor	Rattus norvegicus	84-87
8635568-2	1996	Following administration of NGF, a significant increase (87.3%) in perivascular norepinephrine (NE; microgram/g) was observed when compared with vehicle-infused controls, suggesting that increased sympathetic neurotransmitter accompanies the NGF-induced sprouting response by sympathetic perivascular axons previously observed using electron microscopy (13, 15).	Norepinephrine	80-94	nerve growth factor	Rattus norvegicus	28-31
8635568-4	1996	Thus, when compared with controls, the relative amount of norepinephrine per axon apparently is reduced following NGF infusion.	Norepinephrine	58-72	nerve growth factor	Rattus norvegicus	114-117
8780020-0	1996	Evidence for a role of calmodulin in calcium-induced noradrenaline release from permeated synaptosomes: effects of calmodulin antibodies and antagonists.	Norepinephrine	53-66	calmodulin 1	Rattus norvegicus	23-33
8780020-3	1996	Anti-calmodulin antibodies, which inhibited Ca2+/calmodulin-dependent protein kinase II autophosphorylation and calcineurin phosphatase activity, decreased Ca(2+)-induced nor-adrenaline release from permeated synaptosomes.	Norepinephrine	171-185	calmodulin 1	Rattus norvegicus	5-15
8780020-3	1996	Anti-calmodulin antibodies, which inhibited Ca2+/calmodulin-dependent protein kinase II autophosphorylation and calcineurin phosphatase activity, decreased Ca(2+)-induced nor-adrenaline release from permeated synaptosomes.	Norepinephrine	171-185	calmodulin 1	Rattus norvegicus	49-59
8740147-9	1996	When MAO-B was also inhibited, 10 nmol/l amezinium caused 84% inhibition of the deamination of noradrenaline by MAO-A in the lungs.	Norepinephrine	95-108	monoamine oxidase A	Rattus norvegicus	112-117
8613198-7	1996	Vasoactive substances with the protein kinase C-calcium pathway, such as norepinephrine and angiotensin II, also downregulated the AT2 mRNA level in myocytes.	Norepinephrine	73-87	angiotensin II receptor, type 2	Rattus norvegicus	131-134
8723982-4	1996	RESULTS: Systolic and diastolic blood pressure (SBP and DBP, respectively) were positively related to body mass index, abdomen:hip ratio, norepinephrine excretion, and insulin levels in univariate analyses.	Norepinephrine	138-152	selenium binding protein 1	Homo sapiens	48-51
8723982-5	1996	The relationship between insulin level and SBP and DBP persisted after adjustment for body mass index, abdomen:hip ratio, norepinephrine, age, smoking, physical activity level, and antihypertensive medication use.	Norepinephrine	122-136	selenium binding protein 1	Homo sapiens	25-46
8723982-6	1996	The norepinephrine level was related to SBP and DBP after adjustment for insulin level, age, smoking, physical activity level, and antihypertensive medication use, and these relationships remained marginally significant after further adjustment for body mass index and abdomen:hip ratio.	Norepinephrine	4-18	selenium binding protein 1	Homo sapiens	40-43
8666056-2	1996	The rank order of potency at the rat aorta was the same as that obtained for binding affinity at the rat clonal alpha 1d-adrenoceptor: norepinephrine &gt; epinephrine &gt; cirazoline &gt; phenylephrine &gt; oxymetazoline &gt; A-61603 &gt; methoxamine.	Norepinephrine	135-149	adrenoceptor alpha 1D	Rattus norvegicus	112-133
8821443-10	1996	Our observations indicate that (1) both pyramidal and nonpyramidal neurons are receptive to norepinephrine via alpha 2AAR, (2) alpha 2AAR synthesis is robust prior to synaptogenesis, and (3) alpha 2AAR operates both pre- and postsynaptically.	Norepinephrine	92-106	adrenoceptor alpha 2A	Rattus norvegicus	111-121
8622571-2	1996	Previous results have shown that both dopamine (DA) and norepinephrine (NE) stimulate GnRH secretion in GT1 neuronal cell lines.	Norepinephrine	56-70	retinoic acid induced 1	Mus musculus	104-107
8845008-8	1996	administration of thyrotropin releasing hormone (TRH) (10 nmol/animal) also induced increases in plasma levels of adrenaline and noradrenaline, however, these increases were not modified by i.c.v.	Norepinephrine	129-142	thyrotropin releasing hormone	Rattus norvegicus	18-47
8721251-7	1996	The potency of beta-adrenergic agonists in increasing ODC activity was on the following order: noradrenaline, ritodrine, isoproterenol, clenbuterol.	Norepinephrine	95-108	ornithine decarboxylase	Gallus gallus	54-57
8844771-2	1996	VIP, PHM, PHV, PACAP-27, and PACAP-38 added in single-dose experiments (10(-9), 10(-8), 10(-7), and 10(-6) M) induced all a significant dose-related relaxation of noradrenaline (NA)-precontracted vessels and displayed similar potencies.	Norepinephrine	163-176	VIP peptides	Oryctolagus cuniculus	0-3
8825897-1	1995	The principal brain synaptic vesicular monoamine transporter (VMAT2) is responsible for the reuptake of serotonin, dopamine, norepinephrine, epinephrine, and histamine from the cytoplasm into synaptic vesicles, thus contributing to determination of the size of releasable neurotransmitter vesicular pools.	Norepinephrine	125-139	solute carrier family 18 member A2	Homo sapiens	62-67
8847744-3	1995	Neonatal 6-OHDA injection causes norepinephrine (NE) depletion in the frontal cortex, which triggers a compensatory increase of dopamine, serotonin (5-HT), and met-enkephalin content correlated by the increased density of tyrosine hydroxylase- and 5-HT-positive axons.	Norepinephrine	33-47	tyrosine hydroxylase	Rattus norvegicus	222-242
9072316-4	1995	Cumulative addition of CGRP (10(-11)-10(-7) mol/L) caused endothelium-independent relaxation of arterial rings precontracted with noradrenaline (10(-6) mol/L).	Norepinephrine	130-143	calcitonin-related polypeptide alpha	Rattus norvegicus	23-27
9053735-5	1995	In the presence of indometacin and yohimbine, sulprostone (an agonist at EP1/EP3 receptors) and misoprostol (an agonist at EP2/EP3 receptors) reduced the noradrenaline overflow evoked by stimulation at 3 Hz maximally by about 80% (EC50: 6 nmol/l and 11 nmol/l, respectively).	Norepinephrine	154-167	prostaglandin E receptor 1	Rattus norvegicus	73-90
9053735-9	1995	In conclusion, impulse-induced noradrenaline release in the rat stomach is controlled by multiple presynaptic mechanisms involving alpha 2-adrenergic autoreceptors, EP3 prostanoid and muscarine heteroreceptors, whereas histaminergic mechanisms do not appear to be significant.	Norepinephrine	31-44	prostaglandin E receptor 3	Rattus norvegicus	165-168
8590979-0	1995	Alpha 2C-adrenoceptor-modulated release of noradrenaline in human right atrium.	Norepinephrine	43-56	adrenoceptor alpha 2C	Homo sapiens	0-21
8590997-22	1995	NPY (10 nM) induced a 2.9 fold leftwards shift of the noradrenaline concentration-response curves in PRA and increased maximal response by 50 +/- 16%.	Norepinephrine	54-67	neuropeptide Y	Bos taurus	0-3
8590997-24	1995	[Pro34]NPY (10 nM), but not NPY(13-36), mimicked the potentiating effect of NPY on noradrenaline responses in PRA.	Norepinephrine	83-96	neuropeptide Y	Bos taurus	7-10
8590997-26	1995	TXA2 analogue, U46619, at 10 nM elicited 3.6 fold leftwards shift of the noradrenaline concentration-responses curves in PRA and increased the maximal contraction by 32 +/- 3%, whereas in the presence of 1 microM SQ30741, 10 nM NPY did not potentiate noradrenaline responses.	Norepinephrine	73-86	neuropeptide Y	Bos taurus	228-231
7581987-0	1995	Interactions between angiotensin II and norepinephrine on renin release by juxtaglomerular cells.	Norepinephrine	40-54	renin	Rattus norvegicus	58-63
8697051-7	1995	The relative order of affinity of the various fat cell ARs for the physiological amines defined in binding studies and in vitro assays is alpha 2 &gt; beta 1 &gt; or = beta 2 &gt; beta 3 for norepinephrine and alpha 2 &gt; beta 2 &gt; beta 1 &gt; beta 3 for epinephrine.	Norepinephrine	191-205	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	168-174
8697051-8	1995	When considering differential beta-AR recruitment by catecholamines, it is the beta 1-AR which is always activated at the lowest norepinephrine levels, whatever the species, while the activation of the beta 3-AR requires higher norepinephrine levels.	Norepinephrine	129-143	adrenoceptor beta 1	Homo sapiens	79-88
8588834-2	1995	For this purpose, confocal microscopy was used to analyze sections treated for the double fluorescence immunostaining of dopamine and either noradrenaline or phenylethanolamine-N- methyltransferase (the enzyme in adrenergic neurons that converts noradrenaline into adrenaline).	Norepinephrine	246-259	phenylethanolamine N-methyltransferase	Homo sapiens	158-197
7791817-9	1995	Sympathetic activity in the forearm was greater in blacks than in whites, but isoproterenol-stimulated presynaptic beta 2-adrenergic responses (which facilitated norepinephrine release) did not differ significantly between blacks and whites.	Norepinephrine	162-176	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	115-121
8548177-15	1995	As the expressed alpha 1c-adrenoceptor clone corresponds to the alpha 1A-adrenoceptor expressed in tissues, contraction of the human prostate to noradrenaline is therefore mediated by an alpha 1A-adrenoceptor.	Norepinephrine	145-158	adrenoceptor alpha 1A	Homo sapiens	64-85
8548177-15	1995	As the expressed alpha 1c-adrenoceptor clone corresponds to the alpha 1A-adrenoceptor expressed in tissues, contraction of the human prostate to noradrenaline is therefore mediated by an alpha 1A-adrenoceptor.	Norepinephrine	145-158	adrenoceptor alpha 1A	Homo sapiens	187-208
7607719-7	1995	The decrease in plasma norepinephrine correlated positively with the decreases in beta-thromboglobulin (r = .72, P &lt; .02) and platelet factor 4 (r = .85, P &lt; .01).	Norepinephrine	23-37	pro-platelet basic protein	Homo sapiens	82-102
7607719-7	1995	The decrease in plasma norepinephrine correlated positively with the decreases in beta-thromboglobulin (r = .72, P &lt; .02) and platelet factor 4 (r = .85, P &lt; .01).	Norepinephrine	23-37	platelet factor 4	Homo sapiens	129-146
18800459-6	1995	The neurohormonal effects of AT1 receptor antagonists lead to decreases in plasma norepinephrine, aldosterone and atrial natriuretic peptide and an increase in plasma angiotensin II levels.	Norepinephrine	82-96	angiotensin II receptor type 1	Homo sapiens	29-32
7611522-2	1995	We expected REM sleep deprivation (REMSD) to increase norepinephrine utilization and activate the tyrosine hydroxylase (TH) gene critical for norepinephrine production.	Norepinephrine	142-156	tyrosine hydroxylase	Rattus norvegicus	98-118
7611522-2	1995	We expected REM sleep deprivation (REMSD) to increase norepinephrine utilization and activate the tyrosine hydroxylase (TH) gene critical for norepinephrine production.	Norepinephrine	142-156	tyrosine hydroxylase	Rattus norvegicus	120-122
7582489-0	1995	Elevation of plasma noradrenaline levels in urethane-anaesthetized rats by activation of central prostanoid EP3 receptors.	Norepinephrine	20-33	prostaglandin E receptor 3	Rattus norvegicus	108-111
7761447-5	1995	Cyclic AMP-, protein kinase C-, and calmodulin-dependent second messenger pathways all modulated norepinephrine secretion caused by acetylcholine and high potassium and showed a distinct hierarchy in their effectiveness.	Norepinephrine	97-111	calmodulin 1	Rattus norvegicus	36-46
7670730-19	1995	The present study demonstrates that the alpha 1A-adrenoceptor is the predominant alpha 1-adrenoceptor subtype mediating vasoconstrictor responses to exogenously administered noradrenaline in the isolated perfused kidney of rat.	Norepinephrine	174-187	adrenoceptor alpha 1A	Rattus norvegicus	40-61
7624029-4	1995	Both PACAP 27 and PACAP 38 are able to stimulate proliferation of adult rat chromaffin cells in vitro, either alone or in conjunction with PMA, an activator of protein kinase C. BrdU-labelled nuclei are observed in both epinephrine and norepinephrine cells, and proliferation of both cell types is stimulated by the same concentrations of PACAP that elicit secretion of catecholamines.	Norepinephrine	236-250	adenylate cyclase activating polypeptide 1	Rattus norvegicus	5-10
7624029-4	1995	Both PACAP 27 and PACAP 38 are able to stimulate proliferation of adult rat chromaffin cells in vitro, either alone or in conjunction with PMA, an activator of protein kinase C. BrdU-labelled nuclei are observed in both epinephrine and norepinephrine cells, and proliferation of both cell types is stimulated by the same concentrations of PACAP that elicit secretion of catecholamines.	Norepinephrine	236-250	adenylate cyclase activating polypeptide 1	Rattus norvegicus	18-23
7624029-4	1995	Both PACAP 27 and PACAP 38 are able to stimulate proliferation of adult rat chromaffin cells in vitro, either alone or in conjunction with PMA, an activator of protein kinase C. BrdU-labelled nuclei are observed in both epinephrine and norepinephrine cells, and proliferation of both cell types is stimulated by the same concentrations of PACAP that elicit secretion of catecholamines.	Norepinephrine	236-250	adenylate cyclase activating polypeptide 1	Rattus norvegicus	18-23
7724577-5	1995	The proposed pathway is via norepinephrine-induced release of NO from NOergic neurons, which then activates LHRH release.	Norepinephrine	28-42	gonadotropin releasing hormone 1	Homo sapiens	108-112
7779145-4	1995	Ceruloplasmin exhibited a cardioprotective effect and prevented the oxygen free radical-induced release of noradrenaline, indicating that it can also protect the sympathetic nerve endings from oxygen free-radical injury.	Norepinephrine	107-120	ceruloplasmin	Rattus norvegicus	0-13
7630431-1	1995	Previous studies on the pulmonary removal and metabolism of catecholamines in rat lungs have shown that, when the lungs are perfused with a low concentration (1 nmol/l) of noradrenaline, the amine is metabolized by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO), but is predominantly O-methylated, and the activities of COMT and MAO are 0.357 min-1 and 0.186 min-1, respectively.	Norepinephrine	172-185	monoamine oxidase A	Rattus norvegicus	255-272
7630431-1	1995	Previous studies on the pulmonary removal and metabolism of catecholamines in rat lungs have shown that, when the lungs are perfused with a low concentration (1 nmol/l) of noradrenaline, the amine is metabolized by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO), but is predominantly O-methylated, and the activities of COMT and MAO are 0.357 min-1 and 0.186 min-1, respectively.	Norepinephrine	172-185	monoamine oxidase A	Rattus norvegicus	274-277
7630431-1	1995	Previous studies on the pulmonary removal and metabolism of catecholamines in rat lungs have shown that, when the lungs are perfused with a low concentration (1 nmol/l) of noradrenaline, the amine is metabolized by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO), but is predominantly O-methylated, and the activities of COMT and MAO are 0.357 min-1 and 0.186 min-1, respectively.	Norepinephrine	172-185	monoamine oxidase A	Rattus norvegicus	346-349
7605896-13	1995	In the isolated perfused working rat heart, norepinephrine (3 x 10(-8) M) increased the expression of the proto-oncogenes c-fos and c-myc after 30 and 60 minutes, respectively.	Norepinephrine	44-58	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	132-137
7605896-15	1995	In intact rats, norepinephrine elicited an increase in the mRNA and activity of glucose-6-phosphate dehydrogenase, the first and regulating enzyme of the oxidative pentose phosphate pathway, in a time-dependent manner.	Norepinephrine	16-30	glucose-6-phosphate dehydrogenase	Rattus norvegicus	80-113
7892112-3	1994	Activation of alpha 2-adrenoceptors by clonidine (an alpha 2-adrenoceptor agonist) or noradrenaline (a non-selective alpha-adrenoceptor agonist), both in the presence of 0.1 microM prazosin to block alpha 1-adrenoceptors, caused a slow and sustained increase in [Ca2+]i which was inhibited by 0.1 microM rauwolscine (an alpha 2-adrenoceptor antagonist).	Norepinephrine	86-99	adrenoceptor alpha 2A	Rattus norvegicus	14-35
7986204-5	1994	This relatively small increase in PNMT was reflected in the catecholamine levels in that the total epinephrine (EPI) was elevated by only 16% while norepinephrine (NE) was elevated by 99%, which caused a shift in the molar ratio of EPI to NE from 7.0 in the untreated control to 4.1 after forskolin treatment.	Norepinephrine	148-162	phenylethanolamine N-methyltransferase	Bos taurus	34-38
7990274-4	1994	These results suggested that the hypertension of SHR may be related to the high activity of TH due to the high level of TH mRNA, which increases epinephrine and norepinephrine levels in the adrenal medulla.	Norepinephrine	161-175	tyrosine hydroxylase	Rattus norvegicus	92-94
7990274-4	1994	These results suggested that the hypertension of SHR may be related to the high activity of TH due to the high level of TH mRNA, which increases epinephrine and norepinephrine levels in the adrenal medulla.	Norepinephrine	161-175	tyrosine hydroxylase	Rattus norvegicus	120-122
9296690-0	1994	[The role of renin-angiotensin system in the regulation of noradrenaline inactivation in lungs during immobilization stress in rats].	Norepinephrine	59-72	renin	Rattus norvegicus	13-18
8175974-2	1994	Compared to placebo, BNP induced significant increases in effective renal plasma flow (para-aminohippurate clearance), glomerular filtration rate (creatinine clearance), urine flow rate, and sodium excretion without affecting blood pressure, heart rate, cardiac output (echocardiographic method), peripheral vascular resistance, PRA, plasma aldosterone, or plasma norepinephrine to any significant extent.	Norepinephrine	364-378	natriuretic peptide B	Homo sapiens	21-24
8148373-0	1994	Localization of c-myc protooncogene expression in the rat heart in vivo and in the isolated, perfused heart following treatment with norepinephrine.	Norepinephrine	133-147	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	16-21
8148373-4	1994	In the isolated, perfused heart, addition of norepinephrine to the perfusion buffer and elevation of perfusion pressure separately increase c-myc mRNA suggesting both direct hormonal and hemodynamic factors might be important in vivo.	Norepinephrine	45-59	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	140-145
8148373-5	1994	Immunocytochemistry showed that Myc protein accumulated predominantly in the nuclei of non-myocyte cells following norepinephrine treatment indicating that expression at the mRNA level culminated in protein synthesis.	Norepinephrine	115-129	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	32-35
8148373-6	1994	These findings suggest that the c-myc expression observed in the hypertrophying adult heart following exposure to norepinephrine may be associated with proliferating cells like fibroblasts rather than cardiomyocytes.	Norepinephrine	114-128	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	32-37
8087094-15	1994	Recent experiments have provided complementary evidence for the physiological balance between inhibitory and excitatory transmission resulting in modulation of the action of noradrenaline to evoke LHRH release.	Norepinephrine	174-187	gonadotropin releasing hormone 1	Homo sapiens	197-201
7516996-1	1994	Morphine not only suppresses norepinephrine-induced increases in LHRH mRNA levels but, in these same animals, it simultaneously amplifies norepinephrine (NE)-induced LH release.	Norepinephrine	29-43	gonadotropin releasing hormone 1	Homo sapiens	65-69
7907951-6	1994	Pre-embedding electron microscopy showed GAP-43 immunoreactivity associated with the plasma membranes and cytoplasm of noradrenaline-producing chromaffin cells, and with processes of nonmyelin-forming Schwann cells.	Norepinephrine	119-132	growth associated protein 43	Rattus norvegicus	41-47
27520516-6	1994	COMT inhibitors also decrease the levels of COMT-dependent metabolites of adrenaline (epinephrine) and noradrenaline (norepinephrine) in plasma.Entacapone, to1capone and CGP 28014 improve the bioavailability of levodopa and inhibit the formation of 3-0-methyldopa in human volunteers.	Norepinephrine	103-116	catechol-O-methyltransferase	Homo sapiens	0-4
27520516-6	1994	COMT inhibitors also decrease the levels of COMT-dependent metabolites of adrenaline (epinephrine) and noradrenaline (norepinephrine) in plasma.Entacapone, to1capone and CGP 28014 improve the bioavailability of levodopa and inhibit the formation of 3-0-methyldopa in human volunteers.	Norepinephrine	103-116	catechol-O-methyltransferase	Homo sapiens	44-48
27520516-6	1994	COMT inhibitors also decrease the levels of COMT-dependent metabolites of adrenaline (epinephrine) and noradrenaline (norepinephrine) in plasma.Entacapone, to1capone and CGP 28014 improve the bioavailability of levodopa and inhibit the formation of 3-0-methyldopa in human volunteers.	Norepinephrine	118-132	catechol-O-methyltransferase	Homo sapiens	0-4
27520516-6	1994	COMT inhibitors also decrease the levels of COMT-dependent metabolites of adrenaline (epinephrine) and noradrenaline (norepinephrine) in plasma.Entacapone, to1capone and CGP 28014 improve the bioavailability of levodopa and inhibit the formation of 3-0-methyldopa in human volunteers.	Norepinephrine	118-132	catechol-O-methyltransferase	Homo sapiens	44-48
8156093-5	1994	An exaggerated response of norepinephrine to TRH was observed in hypothyroid patients before therapy (incremental peak (IP) = 0.59 +/- 0.13 nmol/l) but not in hypothyroid patients during therapy (IP = 0.19 +/- 0.02 nmol/l p &lt; 0.02) or in the control group (IP = 0.15 +/- 0.04 nmol/l; p &lt; 0.05).	Norepinephrine	27-41	thyrotropin releasing hormone	Homo sapiens	45-48
8138937-0	1994	Different metabolism of norepinephrine and epinephrine by catechol-O-methyltransferase and monoamine oxidase in rats.	Norepinephrine	24-38	monoamine oxidase A	Rattus norvegicus	91-108
7984279-8	1994	In conclusion, our data indicate that there are clear differences in the effects of 5-HT1A and 5-HT2 receptor-selective drugs on noradrenaline efflux in hippocampus of the anaesthetized versus awake rat.	Norepinephrine	129-142	5-hydroxytryptamine receptor 1A	Rattus norvegicus	84-90
7905411-2	1994	In tissue culture, these tumor cells expressed the brown fat-specific mitochondrial uncoupling protein (Ucp) gene when stimulated by norepinephrine.	Norepinephrine	133-147	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	104-107
7905411-4	1994	We found that the addition of 10(-7)-10(-6) M norepinephrine was critical for establishing cells with high Ucp expression, mitochondrial content, and adipogenesis.	Norepinephrine	46-60	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	107-110
8127399-4	1994	Immunohistochemistry revealed the presence of PACAP-27-LI in the noradrenaline-storing chromaffin cells of the adrenal medulla.	Norepinephrine	65-78	adenylate cyclase activating polypeptide 1	Rattus norvegicus	46-51
8154929-1	1994	Catechol-O-methyltransferase (COMT) is involved in the metabolism of neurotransmitters such as epinephrine, norepinephrine and dopamine.	Norepinephrine	108-122	catechol-O-methyltransferase	Homo sapiens	0-28
8154929-1	1994	Catechol-O-methyltransferase (COMT) is involved in the metabolism of neurotransmitters such as epinephrine, norepinephrine and dopamine.	Norepinephrine	108-122	catechol-O-methyltransferase	Homo sapiens	30-34
8175918-6	1994	Upon transfection of HIB 1B cells with a reporter gene containing the UCP promoter, the activity of the transgene was regulatable by cAMP and norepinephrine.	Norepinephrine	142-156	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	70-73
7931217-0	1994	Modification of cerebral cortical noradrenaline release by chronic inhibition of MAO-A.	Norepinephrine	34-47	monoamine oxidase A	Rattus norvegicus	81-86
7931219-4	1994	The results are in line with the hypothesis that preservation from oxidation of both MAO-A substrates, noradrenaline and serotonin, upon clorgyline administration contributes to the observed increase in melatonin biosynthesis thought to be associated with the anti-depressant effects of MAO inhibition.	Norepinephrine	103-116	monoamine oxidase A	Rattus norvegicus	85-90
7931221-1	1994	This study aimed to examine whether the increase in heart radioactivity levels after intravenous injection of 14C-tyramine to rats pretreated with the irreversible MAO inhibitor tranylcypromine could be antagonized by reboxetine, a potent and selective noradrenaline uptake blocker.	Norepinephrine	253-266	monoamine oxidase A	Rattus norvegicus	164-167
8263536-6	1994	Nevertheless, norepinephrine biosynthesis was inhibited by N-ethylmaleimide, 4-chloro-7-nitrobenzofurazane, and N,N-dicyclohexylcarbodiimide, specific inhibitors of the secretory vesicle ATPase that may directly affect proton pumping.	Norepinephrine	14-28	dynein axonemal heavy chain 8	Homo sapiens	187-193
8579767-5	1994	The amounts of the metabolites by L-amino acid decarboxylase (norepinephrine and its metabolites) were 0.4% of the total amounts of metabolites detected in the dialysate, while those by catechol-O-methyltransferase, 2.1%, and by DOPS-aldolase, 97.5%, after 100 min perfusion of L-threo-DOPS.	Norepinephrine	62-76	leucine rich transmembrane and O-methyltransferase domain containing	Rattus norvegicus	186-217
8264627-1	1994	Previous studies on the regulation of a Ucp minigene in transgenic mice demonstrated that the sequences necessary for brown-fat-specific expression and inducibility by norepinephrine were located in the 5" flanking region between 1 and 2.8 kb from the transcriptional start site.	Norepinephrine	168-182	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	40-43
7969853-4	1994	This suggests that postsynaptic adrenoceptor sensitivity is decreased and, possibly, that presynaptic noradrenaline secretion is increased in ADD-H/CD patients with heroin addiction.	Norepinephrine	102-115	RNA polymerase III subunit A	Homo sapiens	142-150
7953289-2	1994	A proposed mechanism of ligand-activated trans-membrane proton transfer within alpha-helices III, IV, V, VI and VII of the beta 1-adrenoceptor involving activation of a Tyr377-Arg156-Tyr157 proton shuttle by two hydrogen bond proton donor interactions of the natural ligand, nor-adrenaline is found to have an equivalent representation in the m2-muscarinic receptor.	Norepinephrine	275-289	adrenoceptor beta 1	Homo sapiens	123-142
8152624-0	1993	Nerve growth factor induces sensitivity to botulinum neurotoxin type A in norepinephrine-secreting PC12 cells.	Norepinephrine	74-88	nerve growth factor	Rattus norvegicus	0-19
8112823-5	1993	In addition, in these cells, beta-endorphin release is regulated by a classical neurotransmitter, such as noradrenaline, adding some evidence of communication between neurons and microglial cells.	Norepinephrine	106-119	pro-opiomelanocortin-alpha	Mus musculus	29-43
8226929-0	1993	Differential expression of transporters for norepinephrine and glutamate in wild type, variant, and WNT1-expressing PC12 cells.	Norepinephrine	44-58	Wnt family member 1	Rattus norvegicus	100-104
7506268-4	1993	The secretion of GnRH from GT1 cells is stimulated by both norepinephrine and dopamine respectively via beta 1-adrenergic and D1-dopaminergic receptors.	Norepinephrine	59-73	gonadotropin releasing hormone 1	Homo sapiens	17-21
8408651-5	1993	Insulin caused no vasoconstriction in either Af- or Ef-Arts, but it reversed norepinephrine-induced constriction in Ef-Arts but not Af-Arts (suggesting a vasodilator action selective to the Ef-Art): at 200 microU/ml, insulin increased Ef-Art luminal diameter by 75.8 +/- 7.0% from the preconstricted level (n = 6; P &lt; 0.008).	Norepinephrine	77-91	insulin	Oryctolagus cuniculus	0-7
8408651-5	1993	Insulin caused no vasoconstriction in either Af- or Ef-Arts, but it reversed norepinephrine-induced constriction in Ef-Arts but not Af-Arts (suggesting a vasodilator action selective to the Ef-Art): at 200 microU/ml, insulin increased Ef-Art luminal diameter by 75.8 +/- 7.0% from the preconstricted level (n = 6; P &lt; 0.008).	Norepinephrine	77-91	insulin	Oryctolagus cuniculus	217-224
7902547-0	1993	Basic fibroblast growth factor (bFGF, FGF-2) immunoreactivity exists in the noradrenaline, adrenaline and 5-HT nerve cells of the rat brain.	Norepinephrine	76-89	fibroblast growth factor 2	Rattus norvegicus	0-30
7902547-0	1993	Basic fibroblast growth factor (bFGF, FGF-2) immunoreactivity exists in the noradrenaline, adrenaline and 5-HT nerve cells of the rat brain.	Norepinephrine	76-89	fibroblast growth factor 2	Rattus norvegicus	32-36
7902547-0	1993	Basic fibroblast growth factor (bFGF, FGF-2) immunoreactivity exists in the noradrenaline, adrenaline and 5-HT nerve cells of the rat brain.	Norepinephrine	76-89	fibroblast growth factor 2	Rattus norvegicus	38-43
7690708-5	1993	CGRP produced cumulative decreases both in the tension and in R340/380 increased by norepinephrine.	Norepinephrine	84-98	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
7690708-7	1993	The pretreatment with CGRP (10(-6.5) M) also significantly inhibited the norepinephrine-induced increase both in the tension and in R340/380.	Norepinephrine	73-87	calcitonin-related polypeptide alpha	Rattus norvegicus	22-26
8323563-3	1993	Thus, we cultured the cells in the presence of norepinephrine for 24h, and then induced the MHC class II antigen by the addition of interferon-gamma.	Norepinephrine	47-61	major histocompatibility complex, class II, DR beta 6 (pseudogene)	Homo sapiens	92-112
8323563-5	1993	These results suggest that an increase of poly(ADP-ribose) synthetase by norepinephrine cause the inhibition of interferon-gamma-mediated MHC class II antigen expression.	Norepinephrine	73-87	major histocompatibility complex, class II, DR beta 6 (pseudogene)	Homo sapiens	138-158
8403112-9	1993	Subsequently, 16 patients required the infusion of norepinephrine (4-8 micrograms.min-1) to maintain a SBP &gt; 80 mmHg.	Norepinephrine	51-65	selenium binding protein 1	Homo sapiens	103-106
8100175-9	1993	To determine whether the increase in TH protein quantity could be related to a change in norepinephrine (NE) content, the rate constant of disappearance (k) of NE was measured in the catecholaminergic areas of intact or chemodenervated rats submitted to long-term hypoxia.	Norepinephrine	89-103	tyrosine hydroxylase	Rattus norvegicus	37-39
8100176-6	1993	To determine whether the increase in TH protein quantity could be related to a change in norepinephrine (NE) content, the rate constant of disappearance (k) of NE was measured in the catecholaminergic regions of the same rats treated with dihydralazine.	Norepinephrine	89-103	tyrosine hydroxylase	Rattus norvegicus	37-39
8099794-4	1993	This has been attributed to the absence of the norepinephrine-methylating enzyme, phenylethanolamine-N-methyltransferase (PNMT), required for epinephrine synthesis.	Norepinephrine	47-61	phenylethanolamine N-methyltransferase	Homo sapiens	82-120
8099794-4	1993	This has been attributed to the absence of the norepinephrine-methylating enzyme, phenylethanolamine-N-methyltransferase (PNMT), required for epinephrine synthesis.	Norepinephrine	47-61	phenylethanolamine N-methyltransferase	Homo sapiens	122-126
8479290-8	1993	Increased GAP-43 mRNA levels 6 days after vibrissectomy were reproduced by complete transection of the infraorbital nerve and were blocked by depletion of brain norepinephrine.	Norepinephrine	161-175	growth associated protein 43	Rattus norvegicus	10-16
7681896-13	1993	It also attenuated markedly the norepinephrine (NE)-induced increase in the activity of cardiac glucose-6-phosphate dehydrogenase (G-6-PD), the first and rate-limiting enzyme of the oxidative pentose phosphate pathway (PPP), although a 37% stimulation persisted.	Norepinephrine	32-46	glucose-6-phosphate dehydrogenase	Rattus norvegicus	96-129
7681896-13	1993	It also attenuated markedly the norepinephrine (NE)-induced increase in the activity of cardiac glucose-6-phosphate dehydrogenase (G-6-PD), the first and rate-limiting enzyme of the oxidative pentose phosphate pathway (PPP), although a 37% stimulation persisted.	Norepinephrine	32-46	glucose-6-phosphate dehydrogenase	Rattus norvegicus	131-137
8098163-1	1993	Acute treatment with the beta-2 adrenergic agonist zinterol increased norepinephrine (NE) turnover in cerebral cortex and hypothalamus as measured by the rate of disappearance of NE after treatment with alpha-methyl-p-tyrosine.	Norepinephrine	70-84	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	25-31
8093234-0	1993	Cooperative effects of ciliary neurotrophic factor and norepinephrine on tyrosine hydroxylase expression in cultured rat locus coeruleus neurons.	Norepinephrine	55-69	tyrosine hydroxylase	Rattus norvegicus	73-93
8093234-1	1993	Ciliary neurotrophic factor (CNTF) was found to promote the expression of tyrosine hydroxylase (TH) immunoreactivity by cultured noradrenergic neurons from the locus coeruleus (LC) of E18 rat fetuses, but only in the concomitant presence of norepinephrine (NE), their own neurotransmitter.	Norepinephrine	241-255	tyrosine hydroxylase	Rattus norvegicus	96-98
8433522-4	1993	Analysis of transgenic mice indicated that the additional expression of human PNMT in norepinephrine-producing cells can convert these cells to the epinephrine phenotype, and suggested that norepinephrine-producing cells normally possess the fundamental machinery required for the synthesis of epinephrine except for the PNMT expression.	Norepinephrine	86-100	phenylethanolamine N-methyltransferase	Homo sapiens	78-82
8433522-4	1993	Analysis of transgenic mice indicated that the additional expression of human PNMT in norepinephrine-producing cells can convert these cells to the epinephrine phenotype, and suggested that norepinephrine-producing cells normally possess the fundamental machinery required for the synthesis of epinephrine except for the PNMT expression.	Norepinephrine	86-100	phenylethanolamine N-methyltransferase	Homo sapiens	321-325
8433522-4	1993	Analysis of transgenic mice indicated that the additional expression of human PNMT in norepinephrine-producing cells can convert these cells to the epinephrine phenotype, and suggested that norepinephrine-producing cells normally possess the fundamental machinery required for the synthesis of epinephrine except for the PNMT expression.	Norepinephrine	190-204	phenylethanolamine N-methyltransferase	Homo sapiens	78-82
8433522-4	1993	Analysis of transgenic mice indicated that the additional expression of human PNMT in norepinephrine-producing cells can convert these cells to the epinephrine phenotype, and suggested that norepinephrine-producing cells normally possess the fundamental machinery required for the synthesis of epinephrine except for the PNMT expression.	Norepinephrine	190-204	phenylethanolamine N-methyltransferase	Homo sapiens	321-325
1343976-4	1992	In the ewe, noradrenaline, dopamine and serotonin of the brain are implicated in the control of LHRH output, and hence luteinizing hormone (LH) release, during both the anoestrous and breeding seasons.	Norepinephrine	12-25	gonadotropin releasing hormone 1	Homo sapiens	96-100
1359398-9	1992	It is proposed that sustained stimulation of alpha 2-adrenoceptors by endogenous norepinephrine, after inhibition of neuronal uptake, increases their disappearance rate (degradation), leading to a reduction in receptor number.	Norepinephrine	81-95	adrenoceptor alpha 2A	Rattus norvegicus	45-66
1327420-7	1992	Additionally, the effect of norepinephrine on the phosphorylation of GFAP and vimentin was blocked by alprenolol.	Norepinephrine	28-42	vimentin	Rattus norvegicus	78-86
1323843-6	1992	The cultured adipocytes express mRNA for UCP upon stimulation with N6,O2"-dibutyryladenosine 3",5"-cyclic monophosphate, norepinephrine, isoproterenol or D7114, a beta 3 adrenergic agonist.	Norepinephrine	121-135	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	41-44
1407001-1	1992	The uptake and subsequent metabolism by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO) of dopamine, adrenaline, isoprenaline and noradrenaline in isolated perfused lungs of rats has been examined.	Norepinephrine	146-159	monoamine oxidase A	Rattus norvegicus	80-97
1407001-1	1992	The uptake and subsequent metabolism by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO) of dopamine, adrenaline, isoprenaline and noradrenaline in isolated perfused lungs of rats has been examined.	Norepinephrine	146-159	monoamine oxidase A	Rattus norvegicus	99-102
1407001-2	1992	In lung preparations in which COMT and MAO were inhibited, the uptake of 3H-labelled dopamine, (-)-adrenaline and (-)-noradrenaline, but not (+/-)-isoprenaline, was reduced by cocaine (10 or 100 mumol/l).	Norepinephrine	114-131	monoamine oxidase A	Rattus norvegicus	39-42
1407001-5	1992	In lung preparations with COMT and MAO intact, dopamine and noradrenaline were removed from the circulation (50% and 32%, respectively) and mainly metabolized.	Norepinephrine	60-73	monoamine oxidase A	Rattus norvegicus	35-38
1407001-8	1992	If dopamine or adrenaline are perfused through the pulmonary circulation in isolated lungs of the rat, they are taken up and then metabolized by COMT and MAO, as also occurs for noradrenaline.	Norepinephrine	178-191	monoamine oxidase A	Rattus norvegicus	154-157
1511517-9	1992	The segregation of noradrenaline immunoreactivity in the ventral and dorsal horns, the IML and the periependymal area was more obvious at all levels by P14 and P20.	Norepinephrine	19-32	S100 calcium binding protein A9	Rattus norvegicus	152-155
1599423-4	1992	High levels of thermogenin could be induced by noradrenaline treatment in cells grown for more than 5 days in culture, and in such cell cultures continuously stimulated with noradrenaline, the thermogenin level continued to increase for at least a further 5 days.	Norepinephrine	47-60	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	15-26
1303174-1	1992	We have determined the genetic location of the human gene encoding phenylethanolamine N-methyltransferase (PNMT), the terminal enzyme of the catecholamine pathway catalyzing the synthesis of epinephrine (adrenaline) from norepinephrine.	Norepinephrine	221-235	phenylethanolamine N-methyltransferase	Homo sapiens	67-105
1303174-1	1992	We have determined the genetic location of the human gene encoding phenylethanolamine N-methyltransferase (PNMT), the terminal enzyme of the catecholamine pathway catalyzing the synthesis of epinephrine (adrenaline) from norepinephrine.	Norepinephrine	221-235	phenylethanolamine N-methyltransferase	Homo sapiens	107-111
1559367-2	1992	We tested the hypothesis that TNF-alpha causes myocardial depression and alters the cardiac responsiveness to administered norepinephrine.	Norepinephrine	123-137	tumor necrosis factor	Cavia porcellus	30-39
1559367-7	1992	The norepinephrine concentration that elicited a 50% maximal left atrial contractile response (ED50) was higher in TNF-alpha treated animals compared with controls (p less than .05).	Norepinephrine	4-18	tumor necrosis factor	Cavia porcellus	115-124
1559367-9	1992	CONCLUSIONS: These results indicate that TNF-alpha injected in vivo causes in vitro myocardial depression and alters cardiac responsiveness to norepinephrine.	Norepinephrine	143-157	tumor necrosis factor	Cavia porcellus	41-50
1535692-2	1992	The initial rate of uptake of noradrenaline was measured in isolated lungs of rats perfused with 2 nmol/l 3H-(-)-noradrenaline for 2 min with monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT) inhibited, in the absence or presence of drugs that are substrates or inhibitors of Uptake1 or Uptake2 or of alterations in the ionic composition of the Krebs solution.	Norepinephrine	30-43	monoamine oxidase A	Rattus norvegicus	142-159
1535692-2	1992	The initial rate of uptake of noradrenaline was measured in isolated lungs of rats perfused with 2 nmol/l 3H-(-)-noradrenaline for 2 min with monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT) inhibited, in the absence or presence of drugs that are substrates or inhibitors of Uptake1 or Uptake2 or of alterations in the ionic composition of the Krebs solution.	Norepinephrine	30-43	monoamine oxidase A	Rattus norvegicus	161-164
1542654-3	1992	Human PNMT transcripts and immunoreactivity were mainly detected in norepinephrine neurons in brain and sympathetic ganglion as well as in norepinephrine-producing cells in adrenal medulla of transgenic mice, indicating that the human DBH gene promoter of 4 kilobases is sufficient to direct expression of the gene in norepinephrine-producing cells.	Norepinephrine	68-82	phenylethanolamine N-methyltransferase	Homo sapiens	6-10
1542654-3	1992	Human PNMT transcripts and immunoreactivity were mainly detected in norepinephrine neurons in brain and sympathetic ganglion as well as in norepinephrine-producing cells in adrenal medulla of transgenic mice, indicating that the human DBH gene promoter of 4 kilobases is sufficient to direct expression of the gene in norepinephrine-producing cells.	Norepinephrine	139-153	phenylethanolamine N-methyltransferase	Homo sapiens	6-10
1542654-3	1992	Human PNMT transcripts and immunoreactivity were mainly detected in norepinephrine neurons in brain and sympathetic ganglion as well as in norepinephrine-producing cells in adrenal medulla of transgenic mice, indicating that the human DBH gene promoter of 4 kilobases is sufficient to direct expression of the gene in norepinephrine-producing cells.	Norepinephrine	139-153	phenylethanolamine N-methyltransferase	Homo sapiens	6-10
1542654-4	1992	Analysis of catecholamines in the various tissues showed that the expression of human PNMT in transgenic mice induced the appearance of epinephrine in sympathetic ganglion and dramatic changes in norepinephrine and epinephrine levels in brain, adrenal gland, and blood.	Norepinephrine	196-210	phenylethanolamine N-methyltransferase	Homo sapiens	86-90
1346138-8	1992	In contrast, both norepinephrine and CGP-12177 were able to induce the expression of the uncoupling protein thermogenin in the confluent cultured cells.	Norepinephrine	18-32	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	108-119
1589148-1	1992	Endothelin-3 (ET-3) evoked the release of dopamine/noradrenaline from cortical slices and dopamine from striatal slices in a concentration-dependent manner.	Norepinephrine	51-64	endothelin 3	Rattus norvegicus	0-18
1427636-2	1992	At the hypothalamic level, control of gonadotropin releasing hormone (GnRH) involves noradrenaline, GABA, glutamate, angiotensin II, neuropeptide Y, neurotensin, and 5-hydroxytryptamine as well as interleukins 1 and 2.	Norepinephrine	85-98	gonadotropin releasing hormone 1	Homo sapiens	38-68
1427636-2	1992	At the hypothalamic level, control of gonadotropin releasing hormone (GnRH) involves noradrenaline, GABA, glutamate, angiotensin II, neuropeptide Y, neurotensin, and 5-hydroxytryptamine as well as interleukins 1 and 2.	Norepinephrine	85-98	gonadotropin releasing hormone 1	Homo sapiens	70-74
1348181-2	1992	Postganglionic sympathetic nerves were identified using an immunoperoxidase technique in which the primary antiserum was directed against tyrosine hydroxylase, the rate-limiting enzyme in norepinephrine synthesis.	Norepinephrine	188-202	tyrosine 3-monooxygenase	Macaca fascicularis	138-158
1687117-7	1991	On the other hand, for long-term treatment selective beta 1-adrenoceptor antagonists may be beneficial since they protect the heart from the deleterious effects of chronic exposure to high (cardiac derived) noradrenaline and simultaneously may restore the previously reduced beta-adrenoceptor function.	Norepinephrine	207-220	adrenoceptor beta 1	Homo sapiens	53-72
1659547-7	1991	Low concentrations of trimebutine inhibit norepinephrine release via the mu-opioid receptor and enhance intestinal motility by preventing the adrenergic inhibition of acetylcholine release.	Norepinephrine	42-56	mu-type opioid receptor	Cavia porcellus	73-91
1948034-2	1991	The DA transporter is a 619-amino acid protein with 12 hydrophobic putative membrane-spanning domains and homology to the norepinephrine and gamma-aminobutyric acid transporters.	Norepinephrine	122-136	solute carrier family 6 member 3	Rattus norvegicus	4-18
1681086-4	1991	Noradrenaline or isoprenaline in the absence and presence of a selective beta-2 receptor antagonist, or the selective beta-1 adrenergic agonist dobutamine, caused a 2- to 2.5-fold transient lipolytic response which also peaked at 30 min but then (within 3 hr) declined to the base-line level.	Norepinephrine	0-13	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	73-79
1944612-2	1991	These SCN(-)-induced biphasic contractions were also noted in rat aortas precontracted by 80 mM KCl and 100 microM noradrenaline.	Norepinephrine	115-128	sodium voltage-gated channel alpha subunit 2	Rattus norvegicus	6-9
1680223-2	1991	It has been found that the TRH content was increased in both those structures after alpha-MT, an inhibitor of tyrosine hydroxylase which reduced the concentration of both dopamine (DA) and noradrenaline (NA), but not after FLA-63, an inhibitor of DA-beta-hydroxylase which decreased the NA level without affecting DA.	Norepinephrine	189-202	thyrotropin releasing hormone	Rattus norvegicus	27-30
1685558-14	1991	Consistent with this finding, around 80% of the adenylyl cyclase stimulation by both (-)-noradrenaline and (-)-adrenaline was mediated through beta 1AR, around 20% through beta 2AR.	Norepinephrine	85-102	adrenoceptor beta 1	Homo sapiens	143-151
1685558-15	1991	The positive inotropic effects of (-)-noradrenaline appeared to be nearly exclusively mediated through beta 1AR in right ventricular papillary muscles.	Norepinephrine	34-51	adrenoceptor beta 1	Homo sapiens	103-111
1788146-10	1991	In conclusion, receptors capable of interacting with NPY, presumably of the Y1 type, and VIP are present in the rabbit ovarian artery, and activation of these receptors may profoundly influence the response of the artery to norepinephrine.	Norepinephrine	224-238	VIP peptides	Oryctolagus cuniculus	89-92
1646163-7	1991	The application of norepinephrine or 125 mM K+ solution induced contraction in the arterial segments with an accompanying fall in pHi.	Norepinephrine	19-33	glucose-6-phosphate isomerase	Homo sapiens	130-133
1848811-2	1991	In vitro, norepinephrine action at this receptor heterologously down-regulates epidermal growth factor receptors.	Norepinephrine	10-24	epidermal growth factor like 1	Rattus norvegicus	79-102
1996081-1	1991	The stimulation of beta-adrenergic receptors by isoproterenol increases nerve growth factor (NGF) biosynthesis in C6 rat glioma cells, suggesting that norepinephrine may regulate NGF biosynthesis in vivo.	Norepinephrine	151-165	nerve growth factor	Rattus norvegicus	72-91
1996081-1	1991	The stimulation of beta-adrenergic receptors by isoproterenol increases nerve growth factor (NGF) biosynthesis in C6 rat glioma cells, suggesting that norepinephrine may regulate NGF biosynthesis in vivo.	Norepinephrine	151-165	nerve growth factor	Rattus norvegicus	93-96
1996081-1	1991	The stimulation of beta-adrenergic receptors by isoproterenol increases nerve growth factor (NGF) biosynthesis in C6 rat glioma cells, suggesting that norepinephrine may regulate NGF biosynthesis in vivo.	Norepinephrine	151-165	nerve growth factor	Rattus norvegicus	179-182
1912246-5	1991	It is shown that the increase in venous perfusion pressure caused by infusion of noradrenaline into the vascular bed of the shank is essentially equivalent to the increase in mean capillary pressure as determined isovolumetrically.	Norepinephrine	81-94	SH3 and multiple ankyrin repeat domains 2	Homo sapiens	124-129
1879043-4	1991	At 1.5 x 10(-6)-1.5 x 10(-5) M, THP markedly relaxed a contraction induced by 10(-7) M norepinephrine in rat aorta with endothelium but not in that without endothelium.	Norepinephrine	87-101	uromodulin	Rattus norvegicus	32-35
1825947-2	1991	A significant correlation was found between serum noradrenaline and HbA1 at baseline (r = 0.53, p less than 0.025) and after exercise (r = 0.71, p less than 0.001).	Norepinephrine	50-63	hemoglobin subunit alpha 1	Homo sapiens	68-72
1761187-14	1991	However, it is uncertain whether hypothalamic norepinephrine is involved in the hypovolemic thirst mediated via stimulation of renin-angiotensin system.	Norepinephrine	46-60	renin	Rattus norvegicus	127-132
2176208-5	1990	In these cells, it was possible, by using norepinephrine, to induce specifically the synthesis of the UCP but not of F1-ATPase or cytochrome oxidase.	Norepinephrine	42-56	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	102-105
2176208-6	1990	The maximal response was observed at 0.1 microM norepinephrine and the synthesis of UCP remained activated for at least 24 h. Detailed analysis revealed a major role of the beta-adrenergic receptors and elevated intracellular concentration of cAMP in stimulation of UCP synthesis.	Norepinephrine	48-62	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	266-269
1701135-1	1990	The neuropeptide galanin (GAL) is widely distributed throughout the diffuse neuroendocrine system, and is coexpressed with acetylcholine, norepinephrine, prolactin, and a variety of other messenger substances in different cell types.	Norepinephrine	138-152	galanin and GMAP prepropeptide	Bos taurus	26-29
1979509-8	1990	On isolated, electrically driven right atria the beta 1-adrenoceptor-mediated positive inotropic effect of noradrenaline was - even with beta 1-adrenoceptor number increased - not altered, while the beta 2-adrenoceptor-mediated effect of procaterol was markedly enhanced.	Norepinephrine	107-120	adrenoceptor beta 1	Homo sapiens	49-68
2169451-5	1990	In the cirrhotic patients studied, sodium and potassium-activated ATPase inhibition and antidigoxin antibodies directly correlated with the degree of impairment of hepatic and renal function, plasma renin activity and plasma levels of aldosterone and norepinephrine.	Norepinephrine	251-265	dynein axonemal heavy chain 8	Homo sapiens	66-72
2162378-8	1990	In parallel with calmodulin adenylate cyclase, cyclic AMP accumulation elicited by noradrenaline in slices of cerebral cortex was suppressed by both stress and daily CORT injections, with smaller effects observed with CORT in the drinking water.	Norepinephrine	83-96	calmodulin 1	Rattus norvegicus	17-27
2365006-3	1990	In the presence of endothelium, EGF relaxed vascular smooth muscle precontracted with 40 mM K+, 10(-5) M prostaglandin F2 alpha or 10(-6) M norepinephrine.	Norepinephrine	140-154	epidermal growth factor like 1	Rattus norvegicus	32-35
2365006-4	1990	The relaxation induced by EGF was more prominent on the prostaglandin F2 alpha- and norepinephrine-induced contractions than on the K(+)-induced contraction.	Norepinephrine	84-98	epidermal growth factor like 1	Rattus norvegicus	26-29
2259391-0	1990	Inhibition of noradrenaline release by neuropeptide Y does not involve protein kinase C in mouse atria.	Norepinephrine	14-27	neuropeptide Y	Mus musculus	39-53
2259391-1	1990	In this study, we investigated the possible involvement of protein kinase C in the inhibitory effect of neuropeptide Y (NPY) on the electrical stimulation-induced release of radioactivity from mouse atria incubated with [3H]-noradrenaline.	Norepinephrine	225-238	neuropeptide Y	Mus musculus	104-118
2259391-1	1990	In this study, we investigated the possible involvement of protein kinase C in the inhibitory effect of neuropeptide Y (NPY) on the electrical stimulation-induced release of radioactivity from mouse atria incubated with [3H]-noradrenaline.	Norepinephrine	225-238	neuropeptide Y	Mus musculus	120-123
2259391-6	1990	Moreover, in the presence of the protein kinase C inhibitors, K-252a (1 mumol/l) or polymyxin B (70 mumol/l), NPY (0.3 mumol/l) also significantly inhibited the release of noradrenaline.	Norepinephrine	172-185	neuropeptide Y	Mus musculus	110-113
2227123-6	1990	Moreover, although intravenous injection of CGRP (5.67 nmol/kg) elicited a significant increase in plasma epinephrine and norepinephrine concentrations, concomitant administration of epinephrine and norepinephrine, inducing a more prominent rise in plasma catecholamines than those induced by CGRP, affected neither plasma glucose nor insulin levels.	Norepinephrine	122-136	calcitonin-related polypeptide alpha	Rattus norvegicus	44-48
2299343-3	1990	The potentiation of tyramine-induced [3H]noradrenaline release from PC12 cells by MAO-A inhibitors has been linked to the presence of MAO-A in these cells, for which tyramine and noradrenaline are substrates.	Norepinephrine	41-54	monoamine oxidase A	Rattus norvegicus	82-87
2299343-3	1990	The potentiation of tyramine-induced [3H]noradrenaline release from PC12 cells by MAO-A inhibitors has been linked to the presence of MAO-A in these cells, for which tyramine and noradrenaline are substrates.	Norepinephrine	41-54	monoamine oxidase A	Rattus norvegicus	134-139
1688551-6	1990	The physiological alpha-adrenergic agonist norepinephrine also increased aortic PDGF-A mRNA levels.	Norepinephrine	43-57	platelet derived growth factor subunit A	Rattus norvegicus	80-86
2275726-2	1990	It has been observed that subcutaneous administration of noradrenaline, dihydroergotoxine, isoprenaline, propranolol and adrenaline influence the amplitudes of ERG and VEP waves.	Norepinephrine	57-70	transcriptional regulator ERG	Oryctolagus cuniculus	160-163
2089098-2	1990	Three such "metabolizing systems" are involved in the inactivation of noradrenaline: 1) Neuronal uptake (high-affinity uptake1) in association with neuronal MAO (and vesicular uptake), 2) extraneuronal uptake (low affinity uptake2) in association with intracellular COMT and MAO (in smooth muscles, myocardial cells, glands), and 3) uptake1 of non-neuronal cells in association with intracellular COMT and/or MAO (in vascular endothelium of rat lung).	Norepinephrine	70-83	catechol-O-methyltransferase	Homo sapiens	266-270
2089098-2	1990	Three such "metabolizing systems" are involved in the inactivation of noradrenaline: 1) Neuronal uptake (high-affinity uptake1) in association with neuronal MAO (and vesicular uptake), 2) extraneuronal uptake (low affinity uptake2) in association with intracellular COMT and MAO (in smooth muscles, myocardial cells, glands), and 3) uptake1 of non-neuronal cells in association with intracellular COMT and/or MAO (in vascular endothelium of rat lung).	Norepinephrine	70-83	catechol-O-methyltransferase	Homo sapiens	397-401
2089098-7	1990	Hence, membrane-bound COMT appears to be responsible for the extraneuronal O-methylation of noradrenaline.	Norepinephrine	92-105	catechol-O-methyltransferase	Homo sapiens	22-26
2303915-6	1990	Both fractional and calculated turnover of norepinephrine following inhibition of tyrosine 3-monooxygenase by alpha-methyl-p-DL-tyrosine methyl ester (alpha-MT) was higher in hearts from -Cu mice than in those from +Cu mice.	Norepinephrine	43-57	tyrosine hydroxylase	Mus musculus	82-106
2266783-1	1990	This modification of the catechol-O-methyltransferase (COMT) based radioenzymatic assay for norepinephrine (NE) and epinephrine (E) improves sensitivity, selectivity and eliminates many inhibitors of COMT.	Norepinephrine	92-106	catechol-O-methyltransferase	Homo sapiens	25-53
2266783-1	1990	This modification of the catechol-O-methyltransferase (COMT) based radioenzymatic assay for norepinephrine (NE) and epinephrine (E) improves sensitivity, selectivity and eliminates many inhibitors of COMT.	Norepinephrine	92-106	catechol-O-methyltransferase	Homo sapiens	55-59
2266783-1	1990	This modification of the catechol-O-methyltransferase (COMT) based radioenzymatic assay for norepinephrine (NE) and epinephrine (E) improves sensitivity, selectivity and eliminates many inhibitors of COMT.	Norepinephrine	92-106	catechol-O-methyltransferase	Homo sapiens	200-204
33796867-4	2021	This olfactory circuit signals the gut to suppress DR-mediated longevity via octopamine, the mammalian homolog of norepinephrine, by regulating the energy sensor AMPK through a Gq-PLCbeta-CaMKK-dependent mechanism.	Norepinephrine	114-128	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	162-166
33796867-5	2021	In mouse primary cells, we find that norepinephrine signaling regulates AMPK through a similar mechanism.	Norepinephrine	37-51	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	72-76
25459102-1	2015	beta2-Adrenergic receptors (beta2-ARs) transduce the effects of (nor)epinephrine on a variety of cell types and act as key mediators of the body"s reaction to stress.	Norepinephrine	64-80	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	0-5
25459102-1	2015	beta2-Adrenergic receptors (beta2-ARs) transduce the effects of (nor)epinephrine on a variety of cell types and act as key mediators of the body"s reaction to stress.	Norepinephrine	64-80	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	28-33
34871559-8	2022	In addition, the ability of C9 bis(4-aminoquinoline) to modulate the activation of the alpha1A adrenoceptor by norepinephrine was subsequently examined, showing that C9 acted as a non-competitive antagonist.	Norepinephrine	111-125	adrenoceptor alpha 1A	Homo sapiens	87-107
34608562-9	2022	In vessels, there was no change in genetic transcription (RNAseq) or protein expression (immunofluorescence); however, inhibition of GRK2 (paroxetine) led to improved vasodilation to norepinephrine in the old control (OC) and O + SVF, indicating greater GRK2 functional inhibition of beta1-AR in aging.	Norepinephrine	183-197	G protein-coupled receptor kinase 2	Rattus norvegicus	133-137
34853083-0	2022	Hypocretin/orexin interactions with norepinephrine contribute to the opiate withdrawal syndrome.	Norepinephrine	36-50	hypocretin	Mus musculus	0-10
34853083-0	2022	Hypocretin/orexin interactions with norepinephrine contribute to the opiate withdrawal syndrome.	Norepinephrine	36-50	hypocretin	Mus musculus	11-17
34747448-1	2022	BACKGROUND: Ansofaxine (LY03005) extended-release (ER) tablet is a potential triple reuptake inhibitor of serotonin, norepinephrine, and dopamine.	Norepinephrine	117-131	epiregulin	Homo sapiens	51-53
34547331-2	2021	We have found that in doses that support the development of a conditioned taste aversion ethanol increases the activity of tyrosine hydroxylase (TH) positive neurons in the locus coeruleus (LC), a primary source of norepinephrine (NE).	Norepinephrine	215-229	tyrosine hydroxylase	Mus musculus	123-143
34547331-2	2021	We have found that in doses that support the development of a conditioned taste aversion ethanol increases the activity of tyrosine hydroxylase (TH) positive neurons in the locus coeruleus (LC), a primary source of norepinephrine (NE).	Norepinephrine	215-229	tyrosine hydroxylase	Mus musculus	145-147
34470979-2	2021	We reported that noradrenaline inhibits the activity of transient receptor potential vanilloid 1 (TRPV1) evoked by capsaicin through alpha2 receptors in cultured rat dorsal root ganglion (DRG) neurons.	Norepinephrine	17-30	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	56-96
34470979-2	2021	We reported that noradrenaline inhibits the activity of transient receptor potential vanilloid 1 (TRPV1) evoked by capsaicin through alpha2 receptors in cultured rat dorsal root ganglion (DRG) neurons.	Norepinephrine	17-30	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	98-103
34485365-6	2021	In white adipocytes, green tea compounds decreased both basal and norepinephrine-induced UCP1 mRNA levels, and this was associated with the suppression of cell differentiation, indicated by reduced lipogenic gene expression and lipid accumulation.	Norepinephrine	66-80	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	89-93
34083626-3	2021	We found that senior investors display higher gray matter volume and increased structural brain connectivity in dopamine-related pathways, as well as a set of genes functionally associated with adrenaline and noradrenaline biosynthesis (SLC6A3, TH and SLC18A2), which is seemingly involved in reward processing and bodily stress responses during financial trading.	Norepinephrine	209-222	solute carrier family 18 member A2	Homo sapiens	252-259
34206106-5	2021	Finally, the treatment of neonatal cardiomyocytes in culture with EE/Alg/AuNS 2% + Ang-(1-9) 20% pNPs decreased the area and perimeter, demonstrating efficacy in preventing norepinephrine-induced cardiomyocyte hypertrophy.	Norepinephrine	173-187	angiopoietin 1	Homo sapiens	83-91
35615681-3	2022	While cannabigerol can bind to classical cannabinoid receptors, it is also an agonist at alpha2-adrenoreceptors (alpha2AR) which, when activated, inhibit presynaptic norepinephrine release.	Norepinephrine	166-180	adenosine A2a receptor	Mus musculus	113-121
35112881-8	2022	In lean CRIg-/- or C3-/- (complement component 3) mice intravenously injected with gut mEVs, adrenal microbial DNA accumulation elevated adrenal inflammation and norepinephrine secretion, concomitant with hypertension.	Norepinephrine	162-176	V-set and immunoglobulin domain containing 4	Mus musculus	8-12
2557014-5	1989	On the other hand, the reactivity of brown fat to increase expression of UCP and COII mRNAs in response to acute cold or noradrenaline treatment is not impaired during lactation.	Norepinephrine	121-134	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	81-85
2558326-3	1989	Rats chronically cannulated in the right jugular veins showed a time-related increase in plasma corticosterone concentrations in response to intraperitoneal administration of IL-1 that lasted up to 4 h. In the same rats, plasma epinephrine (E) and norepinephrine (NE) concentrations were only slightly elevated (2-fold increase) at 30 min and at 1 h after IL-1 administration.	Norepinephrine	248-262	interleukin 1 complex	Mus musculus	175-179
2789491-7	1989	Responsive vessels exhibited maximal EGF-induced contractions that were approximately 25% of that associated with angiotensin II and were characterized by an ED50 of 7 x 10(-8) M. Relaxant activity of EGF could not be demonstrated in isolated arterial preparations with normal resting tone or with tone elevated by addition of norepinephrine to the tissue bath.	Norepinephrine	327-341	epidermal growth factor like 1	Rattus norvegicus	37-40
2569506-2	1989	Both cell cultures contain adenylate cyclase stimulated by catecholamines with a potency order of isoprenaline greater than adrenaline greater than salbutamol much greater than noradrenaline, which is consistent with the presence of beta 2-adrenergic receptors.	Norepinephrine	177-190	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	233-239
2759199-3	1989	Use of a novel assay to measure tissue A formation revealed that many tissues can synthesize A using PNMT and another enzyme that N-methylates both noradrenaline and dopamine.	Norepinephrine	148-161	phenylethanolamine N-methyltransferase	Homo sapiens	101-105
2756732-6	1989	Cox regression analysis revealed that the ratio of plasma vs myocardial norepinephrine was the best prognostic indicator for patients with an EF less than 30% and this ratio plus the plasma norepinephrine concentration were the best prognostic indicators for the whole group of patients.	Norepinephrine	72-86	cytochrome c oxidase subunit 8A	Homo sapiens	0-3
2719113-5	1989	Norepinephrine decreased the response to VIP (500 pM) but not to higher or lower VIP concentrations.	Norepinephrine	0-14	VIP peptides	Oryctolagus cuniculus	41-44
2497023-0	1989	Brown adipocytes differentiated in vitro can express the gene for the uncoupling protein thermogenin: effects of hypothyroidism and norepinephrine.	Norepinephrine	132-146	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	89-100
2497023-4	1989	However, in cells derived from hypothyroid (methimazole-treated) mice there was a higher expression of thermogenin, and norepinephrine had a marked augmenting effect on the thermogenin mRNA level in these cells.	Norepinephrine	120-134	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	173-184
2497023-6	1989	It was concluded that brown-fat cells in culture can reach a differentiated state, sufficiently advanced that the unique properties of these cells can be expressed, and that thermogenin gene expression (i.e., the level of thermogenin mRNA) is under direct control of norepinephrine.	Norepinephrine	267-281	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	174-185
2497023-6	1989	It was concluded that brown-fat cells in culture can reach a differentiated state, sufficiently advanced that the unique properties of these cells can be expressed, and that thermogenin gene expression (i.e., the level of thermogenin mRNA) is under direct control of norepinephrine.	Norepinephrine	267-281	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	222-233
2715385-2	1989	In this study, the distribution of fibers containing dopamine-beta-hydroxylase (DBH), the enzyme that converts dopamine to norepinephrine, was characterized immunohistochemically in the prefrontal cortical regions of Old World cynomolgus monkeys (Macaca fascicularis) and New World squirrel monkeys (Saimiri sciureus).	Norepinephrine	123-137	dopamine beta-hydroxylase	Macaca fascicularis	53-78
2715385-2	1989	In this study, the distribution of fibers containing dopamine-beta-hydroxylase (DBH), the enzyme that converts dopamine to norepinephrine, was characterized immunohistochemically in the prefrontal cortical regions of Old World cynomolgus monkeys (Macaca fascicularis) and New World squirrel monkeys (Saimiri sciureus).	Norepinephrine	123-137	dopamine beta-hydroxylase	Macaca fascicularis	80-83
2715385-12	1989	Since other data suggest that anti-DBH selectively labels noradrenergic axons in monkey neocortex, the distinctive innervation patterns exhibited by DBH-immunoreactive fibers reveal the regions and layers that may be the principal sites of action of norepinephrine in exerting its effects on prefrontal cortical function.	Norepinephrine	250-264	dopamine beta-hydroxylase	Macaca fascicularis	35-38
2715385-12	1989	Since other data suggest that anti-DBH selectively labels noradrenergic axons in monkey neocortex, the distinctive innervation patterns exhibited by DBH-immunoreactive fibers reveal the regions and layers that may be the principal sites of action of norepinephrine in exerting its effects on prefrontal cortical function.	Norepinephrine	250-264	dopamine beta-hydroxylase	Macaca fascicularis	149-152
2537092-5	1989	The calmodulin antagonist (W-7) inhibited the stimulation-evoked norepinephrine overflow and pressor responses in a dose-dependent manner.	Norepinephrine	65-79	calmodulin 1	Rattus norvegicus	4-14
2537092-8	1989	Further, it is suggested that the marked reduction in stimulation-evoked norepinephrine overflow and vasoconstrictor responses by W-7 showed the greater calmodulin-dependent regulation in the vascular adrenergic activity of DOCA-salt hypertension.	Norepinephrine	73-87	calmodulin 1	Rattus norvegicus	153-163
2913308-2	1989	In addition, these analogues provided information about the effects of conformational flexibility on active-site interaction of the aminoethyl side chain in phenolic phenylethylamines that may aid in learning the manner in which norepinephrine binds at the active site of PNMT.	Norepinephrine	229-243	phenylethanolamine N-methyltransferase	Homo sapiens	272-276
2478663-4	1989	It is suggested that blocking of the oxidation of both MAO-A substrates, noradrenaline and serotonin, upon clorgyline administration results in the observed increase in melatonin synthesis which is thought to contribute to the antidepressant effects of MAO inhibition.	Norepinephrine	73-86	monoamine oxidase A	Rattus norvegicus	55-60
2478663-4	1989	It is suggested that blocking of the oxidation of both MAO-A substrates, noradrenaline and serotonin, upon clorgyline administration results in the observed increase in melatonin synthesis which is thought to contribute to the antidepressant effects of MAO inhibition.	Norepinephrine	73-86	monoamine oxidase A	Rattus norvegicus	55-58
2542808-20	1989	The more efficient activation of contractile force by (-)-noradrenaline in cat, compared to man, appears to be related to a 2-fold higher density of beta 1-adrenoceptors, a 6-fold higher production of cyclic AMP per beta 1-adrenoceptor and possibly to a more effective use of cyclic AMP for contraction.	Norepinephrine	54-71	adrenoceptor beta 1	Homo sapiens	149-168
2844567-7	1988	However, the sympathetic neurotransmitter norepinephrine (NE) decreased both NGF and its mRNA levels specifically in a dose-dependent manner (0.01-1 mM) to a minimum of about 25% of control.	Norepinephrine	42-56	nerve growth factor	Rattus norvegicus	77-80
3244393-9	1988	The effect of cocaine on the overflow of noradrenaline was potentiated by prior inhibition of MAO with clorgyline.	Norepinephrine	41-54	monoamine oxidase A	Rattus norvegicus	94-97
3052110-0	1988	Stimulatory effects of neuronally released norepinephrine on renin release in vitro.	Norepinephrine	43-57	renin	Rattus norvegicus	61-66
3052110-9	1988	These observations suggest to us that the high potassium plus nifedipine-induced increase in renin release from the slices is mediated by norepinephrine derived from renal sympathetic nerves and that this neuronally released norepinephrine stimulates renin release via activation of beta-adrenoceptors.	Norepinephrine	138-152	renin	Rattus norvegicus	93-98
3052110-9	1988	These observations suggest to us that the high potassium plus nifedipine-induced increase in renin release from the slices is mediated by norepinephrine derived from renal sympathetic nerves and that this neuronally released norepinephrine stimulates renin release via activation of beta-adrenoceptors.	Norepinephrine	225-239	renin	Rattus norvegicus	93-98
3052110-9	1988	These observations suggest to us that the high potassium plus nifedipine-induced increase in renin release from the slices is mediated by norepinephrine derived from renal sympathetic nerves and that this neuronally released norepinephrine stimulates renin release via activation of beta-adrenoceptors.	Norepinephrine	225-239	renin	Rattus norvegicus	251-256
2904503-1	1988	Effects of calcium channel blockers and of calmodulin antagonist on the contractile responses to norepinephrine (NE) were compared between strips of mesenteric arteries from 6- and 14-week-old spontaneously hypertensive rats (SHR) and age-matched, normotensive Wistar-Kyoto rats (WKY).	Norepinephrine	97-111	calmodulin 1	Rattus norvegicus	43-53
3372503-1	1988	Phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28) catalyzes the synthesis of epinephrine from norepinephrine, the last step of catecholamine biosynthesis.	Norepinephrine	103-117	phenylethanolamine N-methyltransferase	Homo sapiens	0-38
3372503-1	1988	Phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28) catalyzes the synthesis of epinephrine from norepinephrine, the last step of catecholamine biosynthesis.	Norepinephrine	103-117	phenylethanolamine N-methyltransferase	Homo sapiens	40-44
2899538-4	1988	Of these hormones and drugs, norepinephrine, a alpha-receptor mediator, clearly prevented CT effect on biliary calcium excretion.	Norepinephrine	29-43	calcitonin-related polypeptide alpha	Rattus norvegicus	90-92
3359248-5	1988	In both types of gradient, Met-enkephalin and neuropeptide Y were found in the more dense region of the gradient, coinciding with the main peak of noradrenaline.	Norepinephrine	147-160	neuropeptide Y	Bos taurus	46-60
3359248-8	1988	These results indicate that neuropeptide Y and Met-enkephalin are stored with noradrenaline in "heavy" or large "dense cored" vesicles in the cell bodies of sympathetic neurons of bovine ganglion stellatum.	Norepinephrine	78-91	neuropeptide Y	Bos taurus	28-42
2852942-3	1988	The level of circulating catecholamines (epinephrine, norepinephrine) was significantly higher in patients were severe HF, which probably caused more evident decrease in lymphocyte beta 2-adrenoceptors density in these patients.	Norepinephrine	54-68	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	181-187
2891452-5	1988	The plasma levels of norepinephrine and epinephrine were increased by TRH, while there was no change in plasma renin activity or vasopressin.	Norepinephrine	21-35	thyrotropin releasing hormone	Rattus norvegicus	70-73
2906279-4	1988	The calmodulin antagonist, W-7, reduced not only vasoconstrictor responses but also norepinephrine overflow during nerve stimulation.	Norepinephrine	84-98	calmodulin 1	Rattus norvegicus	4-14
3261256-5	1988	The hypotensive response to 20 nmol noradrenaline (NA) was significantly modified by simultaneous administration of a low dose (40 fmol, ineffective alone) of rCGRP.	Norepinephrine	36-49	calcitonin-related polypeptide alpha	Rattus norvegicus	159-164
3336016-1	1988	beta-Phenylethanolamines have long been known to be substrates for the enzyme that converts norepinephrine to epinephrine (phenylethanolamine N-methyltransferase, PNMT, EC 2.1.1.28).	Norepinephrine	92-106	phenylethanolamine N-methyltransferase	Homo sapiens	123-161
3336016-1	1988	beta-Phenylethanolamines have long been known to be substrates for the enzyme that converts norepinephrine to epinephrine (phenylethanolamine N-methyltransferase, PNMT, EC 2.1.1.28).	Norepinephrine	92-106	phenylethanolamine N-methyltransferase	Homo sapiens	163-167
3420537-3	1988	Following differential centrifugation and sucrose density gradient centrifugation, neuropeptide Y was found to coincide with noradrenaline in the more dense region of the gradient, where the large dense cored vesicles are found.	Norepinephrine	125-138	neuropeptide Y	Bos taurus	83-97
3420537-6	1988	We conclude that in the bovine vas deferens neuropeptide Y is only present in large dense cored vesicles of adrenergic neurons and that the peptide and noradrenaline are co-released from these vesicles in a calcium dependent manner.	Norepinephrine	152-165	neuropeptide Y	Bos taurus	44-58
2446707-4	1987	Administration of the alpha 2-adrenoceptor antagonist idazoxan and the MAO inhibitor tranylcypromine elicited increases in hypothalamic extracellular levels of both adrenaline and noradrenaline by 208% and 229%, respectively.	Norepinephrine	180-193	monoamine oxidase A	Rattus norvegicus	71-74
2887164-4	1987	The stimulatory effect of (-)-noradrenaline is antagonized by beta 1-selective metoprolol and also by beta 2-selective ICI 118,551.	Norepinephrine	26-43	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	102-108
2886078-2	1987	We hypothesized that activation of cardiac beta 2 receptors by endogenously released epinephrine and norepinephrine during surgical stress would add to the positive chronotropic response mediated by beta 1 stimulation.	Norepinephrine	101-115	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	43-49
3114651-6	1987	Fractionation of the effluent showed that release of both free noradrenaline and metabolites was decreased by MAO inhibitor treatment in vivo, but this effect was not reproduced by in vitro incubation of the vas deferens with clorgyline (1 microM).	Norepinephrine	63-76	monoamine oxidase A	Rattus norvegicus	110-113
3114651-9	1987	These results could be explained by a proportionally greater release of tritium from a cytoplasmic compartment following veratrine and KCl than electrical stimulation, since MAO inhibition increases cytoplasmic noradrenaline levels.	Norepinephrine	211-224	monoamine oxidase A	Rattus norvegicus	174-177
3114651-10	1987	Alternatively, release by electrical stimulation may be affected to a greater extent by presynaptic alpha 2-adrenoceptors, and presynaptic receptors may be stimulated by increased synaptic levels of free noradrenaline following MAO inhibition.	Norepinephrine	204-217	monoamine oxidase A	Rattus norvegicus	228-231
2885075-1	1987	The activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in norepinephrine synthesis, was determined in the mediobasal hypothalamus of adult male rats during acute and semistarvation.	Norepinephrine	71-85	tyrosine hydroxylase	Rattus norvegicus	16-36
2885075-1	1987	The activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in norepinephrine synthesis, was determined in the mediobasal hypothalamus of adult male rats during acute and semistarvation.	Norepinephrine	71-85	tyrosine hydroxylase	Rattus norvegicus	38-40
2885075-6	1987	These results suggest that TH activity in the brain contributes to decreased norepinephrine (NE) turnover in starvation.	Norepinephrine	77-91	tyrosine hydroxylase	Rattus norvegicus	27-29
2439680-6	1987	The combination of the maximum effective doses of calcium channel agonists and norepinephrine exerted an apparent additive effect on the release of renin.	Norepinephrine	79-93	renin	Rattus norvegicus	148-153
3031117-9	1987	Vasopressin and norepinephrine stimulated ACTH release to a much lesser extent, but both potentiated the stimulatory effect of CRH.	Norepinephrine	16-30	corticoliberin	Macaca fascicularis	127-130
3796219-1	1987	Dopamine-beta-hydroxylase catalyzes the beta-oxidation of dopamine to noradrenaline while phenylethanolamine-N-methyltransferase converts noradrenaline to adrenaline.	Norepinephrine	138-151	phenylethanolamine N-methyltransferase	Homo sapiens	90-128
3274655-0	1987	Stimulation of the hypothalamic-pituitary-adrenal axis and inhibition of growth hormone release via increased central noradrenaline neuronal activity by urethane anaesthesia in the rat: blockade by clonidine.	Norepinephrine	118-131	gonadotropin releasing hormone receptor	Rattus norvegicus	73-87
2878742-0	1987	Hemodynamic effects of the beta 1-adrenoceptor partial agonist xamoterol in relation to plasma norepinephrine levels during exercise in patients with left ventricular dysfunction.	Norepinephrine	95-109	adrenoceptor beta 1	Homo sapiens	27-46
3038398-7	1987	The marked reduction of the pressor responses and norepinephrine overflow to nerve stimulation by captopril in the SHR suggests that the renin-angiotensin system in the vascular beds in enhanced in this model of hypertension.	Norepinephrine	50-64	renin	Rattus norvegicus	137-142
3035083-2	1987	In the present study it is shown that the GH response to clonidine is weaker in rats exposed to depletion of both noradrenaline and serotonin (by means of reserpine or the combined treatment of FLA-63 and PCPA) than in animals exposed to noradrenaline depletion (by means of FLA-63) only.	Norepinephrine	114-127	gonadotropin releasing hormone receptor	Rattus norvegicus	42-44
3035083-2	1987	In the present study it is shown that the GH response to clonidine is weaker in rats exposed to depletion of both noradrenaline and serotonin (by means of reserpine or the combined treatment of FLA-63 and PCPA) than in animals exposed to noradrenaline depletion (by means of FLA-63) only.	Norepinephrine	238-251	gonadotropin releasing hormone receptor	Rattus norvegicus	42-44
3295118-1	1987	"Metabolizing systems" are responsible for the quick inactivation of noradrenaline released from adrenergic nerve endings: a transport mechanism (uptake1 or uptake2) is arranged in series with the intracellular enzyme (monoamine oxidase, MAO; catechol-O-methyltransferase, COMT).	Norepinephrine	69-82	monoamine oxidase A	Rattus norvegicus	238-241
3295118-5	1987	Second, in the rat vas deferens it is demonstrated that inhibition of neuronal MAO leads to very pronounced rises of the axoplasmic noradrenaline concentration--and this is again a reflection of the high activity of neuronal MAO.	Norepinephrine	132-145	monoamine oxidase A	Rattus norvegicus	79-82
3668521-0	1987	Modification of dopamine and norepinephrine metabolism in the rat brain by monoamine oxidase inhibitors.	Norepinephrine	29-43	monoamine oxidase A	Rattus norvegicus	75-92
3668521-1	1987	The treatment of Sprague-Dawley rats with monoamine oxidase (MAO) inhibitors (pargyline, tranylcypromine) profoundly affects dopamine (DA) and norepinephrine (NE) metabolism in the brain.	Norepinephrine	143-157	monoamine oxidase A	Rattus norvegicus	42-59
3668521-1	1987	The treatment of Sprague-Dawley rats with monoamine oxidase (MAO) inhibitors (pargyline, tranylcypromine) profoundly affects dopamine (DA) and norepinephrine (NE) metabolism in the brain.	Norepinephrine	143-157	monoamine oxidase A	Rattus norvegicus	61-64
33268792-4	2020	Vigilance-dependent astroglial activation is abolished by deletion of alpha1A-adrenergic receptor from astroglia, indicating that norepinephrine acts directly on these ubiquitous glial cells.	Norepinephrine	130-144	adrenergic receptor, alpha 1d	Mus musculus	70-97
33109226-7	2020	Moreover, patch-clamp recording using spinal slices showed that noradrenaline facilitated inhibitory synaptic inputs onto gastrin-releasing peptide receptor-expressing SDH neurons, a neuronal subset known to be essential for itch transmission.	Norepinephrine	64-77	gastrin releasing peptide receptor	Mus musculus	122-156
33178600-9	2020	Luciferase reporter gene experiments further demonstrated that the expression of CD147 is up-regulated primarily by norepinephrine via the beta-Adrenalin receptor (betaAR)-beta-arrestin1-ERK1/2-Sp1 pathway.	Norepinephrine	116-130	mitogen-activated protein kinase 3	Mus musculus	187-193
32398581-17	2020	Performance error calculations showed that SBP was maintained closer to baseline with the norepinephrine infusion.	Norepinephrine	90-104	selenium binding protein 1	Homo sapiens	43-46
32447219-8	2020	The FAAH inhibitor URB597 enhances reduced noradrenaline content, affecting its uptake directly at the level of the spleen.	Norepinephrine	43-56	fatty-acid amide hydrolase-like	Rattus norvegicus	4-8
32727346-7	2020	CONCLUSIONS: LC-NE neuronal firing activity decreased in necdin-deficient mice, suggesting that LC, the primary source of norepinephrine in the central nervous system, is possibly involved in PWS pathogenesis.	Norepinephrine	122-136	necdin, MAGE family member	Mus musculus	57-63
32623336-4	2020	We demonstrated that YAP1 was dephosphorylated and translocated from the cytoplasm to the nucleus by norepinephrine, a process initiated by ADRB2/cAMP/protein kinase A activation.	Norepinephrine	101-115	yes-associated protein 1	Mus musculus	21-25
32623336-5	2020	Furthermore, anoikis resistance and YAP1 activation induced by norepinephrine could be rescued by a broad beta-adrenergic receptor antagonist, propranolol.	Norepinephrine	63-77	yes-associated protein 1	Mus musculus	36-40
32552439-10	2020	In the norepinephrine group compared with the control group, upregulated cleaved caspase-3 protein expression in brain tissue determined by Western blot was reduced (P=0.02) and the densities of apoptotic cells in hippocampal CA1 and CA3 regions determined by terminal deoxynucleotidyl transferase-mediated dUTP biotin nick-end labeling were decreased (P<0.001).	Norepinephrine	7-21	caspase 3	Rattus norvegicus	81-90
32382785-1	2020	RATIONALE: Synaptic neurotransmission with dopamine (DA), norepinephrine (NE), and serotonin (5-HT) is terminated primarily by reuptake into presynaptic terminals via the DA, NE, and 5-HT transporters (DAT/NET/SERT, respectively).	Norepinephrine	58-72	solute carrier family 6 member 3	Rattus norvegicus	202-205
32045472-3	2020	We demonstrate here a role for the beta2-adrenergic receptor (beta2-AR), which binds the stress mediators adrenaline and noradrenaline, in modulating host response to mouse cytomegalovirus (MCMV) infection.	Norepinephrine	121-134	adenosine A2a receptor	Mus musculus	62-70
31570243-8	2020	Plasma syndecan-1 levels were lower in patients with vasoplegic syndrome at the 3 time-points and were associated with the cumulative norepinephrine dose.	Norepinephrine	134-148	syndecan 1	Homo sapiens	7-17
32035089-1	2020	BACKGROUND: Tyrosine hydroxylase (TH) catalyzes the rate-limiting step for the biosynthesis of the catecholamines dopamine, noradrenaline and adrenaline.	Norepinephrine	124-137	tyrosine hydroxylase	Mus musculus	12-32
32035089-1	2020	BACKGROUND: Tyrosine hydroxylase (TH) catalyzes the rate-limiting step for the biosynthesis of the catecholamines dopamine, noradrenaline and adrenaline.	Norepinephrine	124-137	tyrosine hydroxylase	Mus musculus	34-36
30481504-0	2020	Orexin as a modulator of fear-related behavior: Hypothalamic control of noradrenaline circuit.	Norepinephrine	72-85	hypocretin neuropeptide precursor	Homo sapiens	0-6
32162598-1	2020	Aim: Phenylethanolamine N-methyltransferase (PNMT) catalyzes the conversion of sympathetic neurotransmitter norepinephrine to epinephrine.	Norepinephrine	108-122	phenylethanolamine N-methyltransferase	Homo sapiens	5-43
32162598-1	2020	Aim: Phenylethanolamine N-methyltransferase (PNMT) catalyzes the conversion of sympathetic neurotransmitter norepinephrine to epinephrine.	Norepinephrine	108-122	phenylethanolamine N-methyltransferase	Homo sapiens	45-49
31539561-0	2019	Norepinephrine upregulates the expression of tyrosine hydroxylase and protects dopaminegic neurons against 6-hydrodopamine toxicity.	Norepinephrine	0-14	tyrosine hydroxylase	Mus musculus	45-65
31560870-0	2019	Prostaglandin E2 receptor EP3 subtype in the paraventricular hypothalamic nucleus mediates corticotropin-releasing factor-induced elevation of plasma noradrenaline levels in rats.	Norepinephrine	150-163	prostaglandin E receptor 3	Rattus norvegicus	0-37
31560870-7	2019	Our results showed that intracerebroventricular pretreatment with an antagonist of the PGE2 receptor EP3 subtype, but not other subtypes, suppressed CRF-induced elevations in plasma noradrenaline levels.	Norepinephrine	182-195	prostaglandin E receptor 3	Rattus norvegicus	87-112
31306636-1	2019	Different classes of antidepressants, such as tricyclic antidepressants, selective serotonin reuptake inhibitor (SSRI), and serotonin and norepinephrine reuptake inhibitor (SNRI), have been shown to increase GDNF production in astrocytes, which could be a key mechanism of the psychotropic effect of antidepressants.	Norepinephrine	138-152	glial cell derived neurotrophic factor	Rattus norvegicus	208-212
31317231-5	2019	RESULTS: Combined treatment with the peroxisome proliferator-activated receptor gamma (PPARgamma) agonist rosiglitazone, the SMAD3 inhibitor SIS3 and the adrenergic receptor agonist noradrenaline (norepinephrine) synergistically induced Ucp1, Fgf21 and Cited1 expression, triggering brown adipogenesis.	Norepinephrine	182-195	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	237-241
31317231-5	2019	RESULTS: Combined treatment with the peroxisome proliferator-activated receptor gamma (PPARgamma) agonist rosiglitazone, the SMAD3 inhibitor SIS3 and the adrenergic receptor agonist noradrenaline (norepinephrine) synergistically induced Ucp1, Fgf21 and Cited1 expression, triggering brown adipogenesis.	Norepinephrine	182-195	fibroblast growth factor 21	Mus musculus	243-248
31317231-5	2019	RESULTS: Combined treatment with the peroxisome proliferator-activated receptor gamma (PPARgamma) agonist rosiglitazone, the SMAD3 inhibitor SIS3 and the adrenergic receptor agonist noradrenaline (norepinephrine) synergistically induced Ucp1, Fgf21 and Cited1 expression, triggering brown adipogenesis.	Norepinephrine	182-195	Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1	Mus musculus	253-259
31152692-7	2019	We observed an exploration-dependent enhancement of the P300 only, suggesting a critical role of norepinephrine (but not dopamine) in triggering decisions to explore.	Norepinephrine	97-111	E1A binding protein p300	Homo sapiens	56-60
32743496-11	2019	Conclusions: The co-presence of norepinephrine in serum samples can artifactually elevate alpha1AR and beta1AR activity, which can be avoided by serum pre-treatment with MAO.	Norepinephrine	32-46	adrenoceptor beta 1	Homo sapiens	103-110
31048375-6	2019	Norepinephrine increases energy expenditure in brown adipose tissue by providing fatty acid substrate through lipolysis and by increasing expression of uncoupled protein-1 (UCP1).	Norepinephrine	0-14	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	173-177
31127136-9	2019	These findings indicate that BNP and noradrenaline coordinately activate glucose metabolism during ACS, with noradrenaline increasing glucose levels, as an energy substrate, while BNP improves IR and promotes glucose utilization.	Norepinephrine	109-122	natriuretic peptide B	Homo sapiens	29-32
30772446-12	2019	These data suggest that 26RFa microinjected into the contralateral LC induced noradrenaline release in the spinal cord and produced an analgesic effect.	Norepinephrine	78-91	pyroglutamylated RFamide peptide	Rattus norvegicus	24-29
30504424-4	2019	Transwell migration and coculture assays were used to evaluate myeloid cell trafficking and cytokine profile changes evoked by Myc-CaP cells that had been treated with norepinephrine (NE), a major elevated neurotransmitter in depression.	Norepinephrine	168-182	myelocytomatosis oncogene	Mus musculus	127-130
30467710-3	2019	In acute experiments, we found that both nicotine (60 muM) and PACAP (0.1 muM) decreased intracellular norepinephrine (NE) content and increased 3H-NE secretion, with both effects markedly inhibited by co-treatment with CST (2 muM).	Norepinephrine	103-117	adenylate cyclase activating polypeptide 1	Rattus norvegicus	63-68
30232529-1	2019	RATIONALE: Synthetic cathinones constitute a class of abused drugs that can act at dopamine, norepinephrine, and serotonin transporters (DAT, NET, and SERT, respectively).	Norepinephrine	93-107	solute carrier family 6 member 3	Rattus norvegicus	137-140
30472113-9	2019	Taken together, our data present evidence of unexpected asocial tendencies in heterozygous (DAT-HET) rats associated with neurochemical alterations in norepinephrine neurotransmission.	Norepinephrine	151-165	solute carrier family 6 member 3	Rattus norvegicus	92-95
30388565-6	2019	Moreover, the coordinated catalysis of bi-enzymes (laccase and glucose dehydrogenase) could avoid the fluctuated concentration of detection target (e.g. norepinephrine), while the application of bi-nanospheres loaded with large amount of enzymes could effectively amplify the signal of biosensors.	Norepinephrine	153-167	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	51-84
30389842-11	2019	Epigenetic tuning of CAPS variants may allow modulation of endocrine adrenaline and noradrenaline release.	Norepinephrine	84-97	Ca2+-dependent secretion activator	Mus musculus	21-25
30399587-10	2019	Contractions induced by norepinephrine were primarily inhibited by the COX2 inhibitor, but not the NOS inhibitor, and the expression of COX2 was downregulated after TRPV4 inhibition.	Norepinephrine	24-38	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	71-75
29878130-9	2018	Similarly, UCP2 and UCP3 protein levels were increased in differentiated adipocytes upon acute norepinephrine stimulation.	Norepinephrine	95-109	uncoupling protein 2	Homo sapiens	11-15
30139713-4	2018	A61603, a alpha1A-adrenoceptor agonist, was a full agonist with a potency 21-fold greater than that of noradrenaline.	Norepinephrine	103-116	adrenoceptor alpha 1A	Homo sapiens	10-30
29480946-6	2018	In addition, the enhancing effect of norepinephrine (NE) on melatonin synthesis was abolished by Isl1 knockdown.	Norepinephrine	37-51	ISL LIM homeobox 1	Sus scrofa	97-101
29802242-4	2018	Testosterone deficiency by castration causes expansion of BAFF-producing fibroblastic reticular cells (FRCs) in spleen, which may be coupled to lower splenic noradrenaline levels in castrated males, as an alpha-adrenergic agonist decreases splenic FRC number in vitro.	Norepinephrine	158-171	TNF superfamily member 13b	Homo sapiens	58-62
29575696-8	2018	In addition, central leptin decreased serum and hepatic endogenous norepinephrine levels of FR rats, exerting a homeostatic effect beyond its antisteatotic actions.	Norepinephrine	67-81	leptin	Rattus norvegicus	21-27
29328415-3	2018	The primary source of noradrenaline in the central nervous system is tyrosine hydroxylase (TH)-positive neurons, located in the locus coeruleus (LC).	Norepinephrine	22-35	tyrosine hydroxylase	Mus musculus	69-89
29328415-3	2018	The primary source of noradrenaline in the central nervous system is tyrosine hydroxylase (TH)-positive neurons, located in the locus coeruleus (LC).	Norepinephrine	22-35	tyrosine hydroxylase	Mus musculus	91-93
29328415-4	2018	TH is the rate-limiting enzyme for noradrenaline synthesis; therefore, regulation of TH protein expression and intrinsic enzyme activity represents the central means for controlling the synthesis of noradrenaline.	Norepinephrine	35-48	tyrosine hydroxylase	Mus musculus	0-2
29328415-4	2018	TH is the rate-limiting enzyme for noradrenaline synthesis; therefore, regulation of TH protein expression and intrinsic enzyme activity represents the central means for controlling the synthesis of noradrenaline.	Norepinephrine	35-48	tyrosine hydroxylase	Mus musculus	85-87
29328415-4	2018	TH is the rate-limiting enzyme for noradrenaline synthesis; therefore, regulation of TH protein expression and intrinsic enzyme activity represents the central means for controlling the synthesis of noradrenaline.	Norepinephrine	199-212	tyrosine hydroxylase	Mus musculus	0-2
29328415-4	2018	TH is the rate-limiting enzyme for noradrenaline synthesis; therefore, regulation of TH protein expression and intrinsic enzyme activity represents the central means for controlling the synthesis of noradrenaline.	Norepinephrine	199-212	tyrosine hydroxylase	Mus musculus	85-87
29267189-2	2017	Besides a variety of reports showing the involvement of norepinephrine and its receptor systems in cognition, amyloid beta (Abeta) metabolism, neuroinflammation, and neurogenesis, little is known about the contribution of the specific receptors to these actions.	Norepinephrine	56-70	amyloid beta (A4) precursor protein	Mus musculus	124-129
29209170-0	2017	Noradrenaline Modulates the Membrane Potential and Holding Current of Medial Prefrontal Cortex Pyramidal Neurons via beta1-Adrenergic Receptors and HCN Channels.	Norepinephrine	0-13	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	148-151
29209170-10	2017	Thus, noradrenaline controls the resting membrane potential and holding current in mPFC pyramidal neurons through beta1-adrenergic receptors, which in turn activate HCN channels via a signaling pathway involving the betagamma subunit.	Norepinephrine	6-19	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	165-168
28746816-2	2017	Choline acetyltransferase (ChAT), enzyme forming acetylcholine, tyrosine hydroxylase (TH), and dopamine-beta-hydroxylase (DBH), enzymes participating in noradrenaline synthesis, are responsible for the production of classical neurotransmitters, and atrial natriuretic peptide (ANP) is produced by cardiomyocytes.	Norepinephrine	153-166	dopamine beta-hydroxylase	Rattus norvegicus	122-125
28583436-9	2017	Stepwise regression analysis revealed that %FABP4 was highly correlated with that in norepinephrine.	Norepinephrine	85-99	fatty acid binding protein 4	Homo sapiens	44-49
28583436-10	2017	CONCLUSIONS: Our study reveals the significant correlation between circulating FABP4 and norepinephrine levels during exercise testing.	Norepinephrine	89-103	fatty acid binding protein 4	Homo sapiens	79-84
28979194-0	2017	The Locus Coeruleus-Norepinephrine System Mediates Empathy for Pain through Selective Up-Regulation of P2X3 Receptor in Dorsal Root Ganglia in Rats.	Norepinephrine	20-34	purinergic receptor P2X 3	Rattus norvegicus	103-107
28412373-10	2017	Although the density of dopamine transporter is low in cortex, the increase of dopamine and norepinephrine levels in cortex could be mediated through the inhibition of norepinephrine transporter.	Norepinephrine	92-106	solute carrier family 6 member 2	Rattus norvegicus	168-194
28412373-11	2017	In the dorsal horn, increase in norepinephrine levels could be due to inhibition of norepinephrine transporter in the spinal cord.	Norepinephrine	32-46	solute carrier family 6 member 2	Rattus norvegicus	84-110
28389717-5	2017	Selective blockade of beta1 (CGP20712) or beta3 (SR59230A), but not beta2 (ICI118,551) adrenoceptors, greatly increased alpha-adrenergic constriction (norepinephrine) of aorta in female SHRs, but not in male SHRs at 12 weeks of age.	Norepinephrine	151-165	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	42-47
28539820-10	2017	eNOS inhibition increased the response to noradrenaline in the three groups with a significant lower magnitude in aortic rings from obese mice receiving bifidobacteria supplement.	Norepinephrine	42-55	nitric oxide synthase 3, endothelial cell	Mus musculus	0-4
27979380-7	2017	Interestingly, NPY decreased brain serotonin and norepinephrine concentrations in fed chicks, but increased concentrations of brain dopamine and its metabolites in fasted and fed chicks, respectively.	Norepinephrine	49-63	neuropeptide Y	Homo sapiens	15-18
27979380-8	2017	Plasma epinephrine was decreased by NPY in fed chicks, but plasma concentrations of norepinephrine and epinephrine were increased significantly by NPY in fasted-heat exposed chicks.	Norepinephrine	84-98	neuropeptide Y	Homo sapiens	147-150
27776953-2	2017	Dopamine beta-hydroxylase (DBH) gene associated with dopamine and norepinephrine systems influences cognition.	Norepinephrine	66-80	dopamine beta-hydroxylase	Homo sapiens	0-25
27776953-2	2017	Dopamine beta-hydroxylase (DBH) gene associated with dopamine and norepinephrine systems influences cognition.	Norepinephrine	66-80	dopamine beta-hydroxylase	Homo sapiens	27-30
27753095-16	2017	Noradrenaline also evoked TRPC1 channel activity and associations between TRPC1, STIM1, Galphaq and PLCbeta1, which were inhibited by STIM1 knockdown.	Norepinephrine	0-13	G protein subunit alpha q	Homo sapiens	88-95
28066248-2	2016	One of the main enzymes to take into account in pharmacogenomics is catechol O-methyltransferase (COMT), which catalyzes the transfer of a methyl group from S-adenosylmethionine to catechols and catecholamines, like the neurotransmitters dopamine, epinephrine, and norepinephrine.	Norepinephrine	265-279	catechol-O-methyltransferase	Rattus norvegicus	68-96
28066248-2	2016	One of the main enzymes to take into account in pharmacogenomics is catechol O-methyltransferase (COMT), which catalyzes the transfer of a methyl group from S-adenosylmethionine to catechols and catecholamines, like the neurotransmitters dopamine, epinephrine, and norepinephrine.	Norepinephrine	265-279	catechol-O-methyltransferase	Rattus norvegicus	98-102
27959576-6	2016	We found modestly increased adrenal expression of Dbh in transgenic rats versus SHR non-transgenic controls that was associated with reduced adrenal levels of dopamine and increased plasma levels of norepinephrine and epinephrine.	Norepinephrine	199-213	dopamine beta-hydroxylase	Rattus norvegicus	50-53
27650061-0	2016	Norepinephrine inhibits mesenchymal stem cell chemotaxis migration by increasing stromal cell-derived factor-1 secretion by vascular endothelial cells via NE/abrd3/JNK pathway.	Norepinephrine	0-14	mitogen-activated protein kinase 8	Rattus norvegicus	164-167
26667034-1	2016	The dopamine beta-hydroxylase (DbetaH) enzyme transforms dopamine into noradrenaline.	Norepinephrine	71-84	dopamine beta-hydroxylase	Homo sapiens	4-29
27979701-0	2016	GPR40/FFAR1 deficient mice increase noradrenaline levels in the brain and exhibit abnormal behavior.	Norepinephrine	36-49	free fatty acid receptor 1	Mus musculus	0-5
27979701-0	2016	GPR40/FFAR1 deficient mice increase noradrenaline levels in the brain and exhibit abnormal behavior.	Norepinephrine	36-49	free fatty acid receptor 1	Mus musculus	6-11
27979701-11	2016	Therefore, these results suggest that brain GPR40/FFAR1 is associated with anxiety- and depression-related behavior regulated by the increment of noradrenaline in the brain.	Norepinephrine	146-159	free fatty acid receptor 1	Mus musculus	44-49
27979701-11	2016	Therefore, these results suggest that brain GPR40/FFAR1 is associated with anxiety- and depression-related behavior regulated by the increment of noradrenaline in the brain.	Norepinephrine	146-159	free fatty acid receptor 1	Mus musculus	50-55
26916829-1	2016	It has been shown that oleuropein, a phenolic compound in the fruit and leaves of the olive tree (Olea europaea) induces mammalian uncoupling protein 1 (UCP1) expression via an increased secretion of noradrenaline and adrenaline.	Norepinephrine	200-213	uncoupling protein 1	Homo sapiens	153-157
27194378-3	2016	Dopamine beta-hydroxylase (DBH) converts dopamine to norepinephrine; the T allele of a functional single-nucleotide polymorphism rs1611115 (C-1021T) in the DBH gene is associated with less DBH activity and has been linked to emotional processes and addiction.	Norepinephrine	53-67	dopamine beta-hydroxylase	Homo sapiens	0-25
27194378-3	2016	Dopamine beta-hydroxylase (DBH) converts dopamine to norepinephrine; the T allele of a functional single-nucleotide polymorphism rs1611115 (C-1021T) in the DBH gene is associated with less DBH activity and has been linked to emotional processes and addiction.	Norepinephrine	53-67	dopamine beta-hydroxylase	Homo sapiens	27-30
27194378-3	2016	Dopamine beta-hydroxylase (DBH) converts dopamine to norepinephrine; the T allele of a functional single-nucleotide polymorphism rs1611115 (C-1021T) in the DBH gene is associated with less DBH activity and has been linked to emotional processes and addiction.	Norepinephrine	53-67	dopamine beta-hydroxylase	Homo sapiens	156-159
27194378-3	2016	Dopamine beta-hydroxylase (DBH) converts dopamine to norepinephrine; the T allele of a functional single-nucleotide polymorphism rs1611115 (C-1021T) in the DBH gene is associated with less DBH activity and has been linked to emotional processes and addiction.	Norepinephrine	53-67	dopamine beta-hydroxylase	Homo sapiens	156-159
27224648-9	2016	A positive correlation was also found between urinary noradrenaline and adrenaline levels and LAT1 gene expression in PHEO.	Norepinephrine	54-67	solute carrier family 7 member 5	Homo sapiens	94-98
27148966-1	2016	Dopamine beta-hydroxylase (DBH) converts dopamine (DA) to norepinephrine (NE) in noradrenergic/adrenergic cells.	Norepinephrine	58-72	dopamine beta-hydroxylase	Homo sapiens	0-25
27148966-1	2016	Dopamine beta-hydroxylase (DBH) converts dopamine (DA) to norepinephrine (NE) in noradrenergic/adrenergic cells.	Norepinephrine	58-72	dopamine beta-hydroxylase	Homo sapiens	27-30
27152332-3	2016	We report the crystal structure of human dopamine beta-hydroxylase, which is the enzyme converting dopamine to norepinephrine.	Norepinephrine	111-125	dopamine beta-hydroxylase	Homo sapiens	41-66
26790973-9	2016	In contrast, early postoperative parameters revealed a higher correlation with the occurrence of mesenteric ischemia including the use of norepinephrine (OR 3.5 CI95% 1.6-7.8), epinephrine (OR 2.0, CI95% 1.1-3.7), and serum lactate levels &gt;3 mmol/L (OR 2.9, CI95% 1.5-5.6).	Norepinephrine	138-152	olfactory receptor family 5 subfamily H member 4 pseudogene	Homo sapiens	154-160
26663782-0	2016	Norepinephrine Controls Effector T Cell Differentiation through beta2-Adrenergic Receptor-Mediated Inhibition of NF-kappaB and AP-1 in Dendritic Cells.	Norepinephrine	0-14	adrenergic receptor, beta 2	Mus musculus	64-89
26556532-2	2016	Noradrenaline (NA) is one of the main modulators of GnRH release, and NA fibers are found in close apposition to kisspeptin neurons in the RP3V.	Norepinephrine	0-13	gonadotropin releasing hormone 1	Rattus norvegicus	52-56
26025460-0	2016	Erythropoietin Reverses Sepsis-Induced Vasoplegia to Norepinephrine Through Preservation of alpha1D-Adrenoceptor mRNA Expression and Inhibition of GRK2-Mediated Desensitization in Mouse Aorta.	Norepinephrine	53-67	erythropoietin	Mus musculus	0-14
26008896-2	2015	Neuropeptide Y (NPY) is a neurotransmitter that is co-released with norepinephrine and is up-regulated during increased sympathetic activity.	Norepinephrine	68-82	neuropeptide Y	Homo sapiens	0-14
26008896-2	2015	Neuropeptide Y (NPY) is a neurotransmitter that is co-released with norepinephrine and is up-regulated during increased sympathetic activity.	Norepinephrine	68-82	neuropeptide Y	Homo sapiens	16-19
26523867-2	2015	Here we found that the transcription factor Nr4a1 regulated the production of norepinephrine (NE) in macrophages and thereby limited experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis.	Norepinephrine	78-92	nuclear receptor subfamily 4, group A, member 1	Mus musculus	44-49
26181106-6	2015	2) Among the neurotransmitter receptors, adrenergic receptors alpha1a, alpha2a, alpha2b, and beta1 were all highly expressed, with norepinephrine and isoproterenol acting as positive regulators.	Norepinephrine	131-145	adrenergic receptor, alpha 2b	Mus musculus	80-87
26181106-6	2015	2) Among the neurotransmitter receptors, adrenergic receptors alpha1a, alpha2a, alpha2b, and beta1 were all highly expressed, with norepinephrine and isoproterenol acting as positive regulators.	Norepinephrine	131-145	hemoglobin, beta adult major chain	Mus musculus	93-98
26403854-10	2015	In multiple regression analysis, renalase was predicted by plasma dopamine and norepinephrine as also diastolic office blood pressure and left ventricle ejection fraction.	Norepinephrine	79-93	renalase, FAD dependent amine oxidase	Homo sapiens	33-41
26444903-7	2015	Increases in hnRNP R additionally improved AANAT production in rat pinealocytes under norepinephrine (NE) treatment.	Norepinephrine	86-100	aralkylamine N-acetyltransferase	Rattus norvegicus	43-48
26362189-8	2015	Taken together, our data suggest that curcumin can potentially prevent obesity by inducing browning of inguinal WAT via the norepinephrine-beta3AR pathway.	Norepinephrine	124-138	adrenergic receptor, beta 3	Mus musculus	139-146
26173457-7	2015	Within the adrenal medulla, pendrin localizes to both epinephrine- and norepinephrine-producing chromaffin cells.	Norepinephrine	71-85	solute carrier family 26, member 4	Mus musculus	28-35
26173457-11	2015	With 20 min of immobilization stress, epinephrine and norepinephrine concentrations increased more in pendrin-null than in wild-type mice, although stress produced a similar increase in blood pressure in both groups.	Norepinephrine	54-68	solute carrier family 26, member 4	Mus musculus	102-109
26002194-0	2015	Life-long norepinephrine transporter (NET) knock-out leads to the increase in the NET mRNA in brain regions rich in norepinephrine terminals.	Norepinephrine	10-24	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Mus musculus	38-41
26002194-0	2015	Life-long norepinephrine transporter (NET) knock-out leads to the increase in the NET mRNA in brain regions rich in norepinephrine terminals.	Norepinephrine	10-24	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Mus musculus	82-85
26002194-5	2015	Surprisingly, the studies have shown that the mRNA encoding NET accumulated in the brain regions rich in norepinephrine nerve endings in the NET-KO mice.	Norepinephrine	105-119	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Mus musculus	60-63
26002194-5	2015	Surprisingly, the studies have shown that the mRNA encoding NET accumulated in the brain regions rich in norepinephrine nerve endings in the NET-KO mice.	Norepinephrine	105-119	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Mus musculus	141-144
26049174-10	2015	Mesenteric arteries from high-fat-BK beta1-knockout mice had higher norepinephrine reactivity, greater wall thickness and collagen accumulation than high-fat-wild-type mesenteric arteries.	Norepinephrine	68-82	hemoglobin, beta adult major chain	Mus musculus	37-42
25869507-7	2015	The combined treatment reversed the hyporeactivity to nor-adrenaline through preservation of alpha1D AR mRNA/protein expression and reversal of alpha1D AR desensitization mediated by GRK2/Gbetagamma pathway.	Norepinephrine	54-68	G protein-coupled receptor kinase 2	Mus musculus	183-187
25956992-0	2015	Stabilization of Alpha-Synuclein Oligomers In Vitro by the Neurotransmitters, Dopamine and Norepinephrine: The Effect of Oxidized Catecholamines.	Norepinephrine	91-105	synuclein alpha	Homo sapiens	17-32
25956992-2	2015	The neurotransmitters dopamine and norepinephrine have been shown to both inhibit the formation of these fibrils and disaggregate existing fibrils, yielding the more toxic oligomeric form of alpha-synuclein.	Norepinephrine	35-49	synuclein alpha	Homo sapiens	191-206
25818584-9	2015	Norepinephrine also decreased mRNA expression of osterix, collagen I, and osteocalcin by mesenchymal stem cells at 7 and 14 d of stimulation and increased the expression of RANKL and RANKL/OPG ratio by mesenchymal stem cells at 2 h. In conclusion, CIS and UAC synergistically promote condylar subchondral bone loss and cartilage degradation; such processes are partially regulated by norepinephrine within subchondral bone.	Norepinephrine	0-14	bone gamma-carboxyglutamate protein 2	Mus musculus	74-85
25818584-9	2015	Norepinephrine also decreased mRNA expression of osterix, collagen I, and osteocalcin by mesenchymal stem cells at 7 and 14 d of stimulation and increased the expression of RANKL and RANKL/OPG ratio by mesenchymal stem cells at 2 h. In conclusion, CIS and UAC synergistically promote condylar subchondral bone loss and cartilage degradation; such processes are partially regulated by norepinephrine within subchondral bone.	Norepinephrine	0-14	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	173-178
25818584-9	2015	Norepinephrine also decreased mRNA expression of osterix, collagen I, and osteocalcin by mesenchymal stem cells at 7 and 14 d of stimulation and increased the expression of RANKL and RANKL/OPG ratio by mesenchymal stem cells at 2 h. In conclusion, CIS and UAC synergistically promote condylar subchondral bone loss and cartilage degradation; such processes are partially regulated by norepinephrine within subchondral bone.	Norepinephrine	0-14	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	183-188
25344273-6	2015	In these conditions, sympathetic neurotransmitters such as neuropeptide Y (NPY) can be released in addition to noradrenaline, and plasma levels correlate with infarct size and mortality.	Norepinephrine	111-124	neuropeptide Y	Homo sapiens	59-73
25799564-9	2015	It was observed that when alpha1B-adrenergic receptors were stimulated with noradrenaline, the receptors interacted with proteins present in early endosomes, such as the early endosomes antigen 1, Rab 5, Rab 4, and Rab 11 but not with late endosome markers, such as Rab 9 and Rab 7.	Norepinephrine	76-89	RAB5A, member RAS oncogene family	Homo sapiens	197-202
25498224-1	2015	Norepinephrine acting via beta-adrenergic receptors (beta-ARs) plays an important role in hippocampal plasticity including the subiculum which is the principal target of CA1 pyramidal cells and which controls information transfer from the hippocampus to other brain regions including the neighboring presubiculum and the entorhinal cortex (EC).	Norepinephrine	0-14	carbonic anhydrase 1	Rattus norvegicus	170-173
25497549-9	2015	In addition, the levels of norepinephrine in serum as well as nicotinamide adenine dinucleotide (NAD(+)) and ATP in myocardium were determined, which implied that cardiac protection of renalase against I/R may be related, at least in part, to its metabolism of catecholamine and regulation of energy.	Norepinephrine	27-41	renalase, FAD-dependent amine oxidase	Mus musculus	185-193
24986918-1	2014	Dopamine beta-hydroxylase (DBH) is the biosynthetic enzyme catalyzing formation of norepinephrine.	Norepinephrine	83-97	dopamine beta-hydroxylase	Homo sapiens	0-25
24986918-1	2014	Dopamine beta-hydroxylase (DBH) is the biosynthetic enzyme catalyzing formation of norepinephrine.	Norepinephrine	83-97	dopamine beta-hydroxylase	Homo sapiens	27-30
25220264-1	2014	Monoamine oxidases (MAOs) A and B are flavoenzymes responsible for the metabolism of biogenic amines such as dopamine, serotonin and noradrenaline.	Norepinephrine	133-146	monoamine oxidase A	Homo sapiens	0-33
25131562-8	2014	Triple-labeling immunocytochemistry revealed that alpha2A-AR and CB1R were localised to processes that contained dopamine-beta-hydroxylase, a marker of norepinephrine.	Norepinephrine	152-166	dopamine beta-hydroxylase	Rattus norvegicus	113-138
24863408-3	2014	In the present study, we examined the effects of the stress-related catecholamines adrenaline and noradrenaline on macrophage expression of TG2 in RAW264.7 murine macrophages and murine bone marrow-derived macrophages.	Norepinephrine	98-111	transglutaminase 2, C polypeptide	Mus musculus	140-143
24863408-6	2014	Noradrenaline also increased TG2 mRNA expression at higher doses than the effective doses of adrenaline.	Norepinephrine	0-13	transglutaminase 2, C polypeptide	Mus musculus	29-32
23988761-1	2014	Dopamine beta-hydroxylase (DBH), an enzyme that converts dopamine to norepinephrine, has broad influences on social functions.	Norepinephrine	69-83	dopamine beta-hydroxylase	Homo sapiens	0-25
23988761-1	2014	Dopamine beta-hydroxylase (DBH), an enzyme that converts dopamine to norepinephrine, has broad influences on social functions.	Norepinephrine	69-83	dopamine beta-hydroxylase	Homo sapiens	27-30
24817036-2	2014	One of many biochemical actions of disulfiram is inhibition of dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine (DA) to norepinephrine (NE) in noradrenergic neurons.	Norepinephrine	138-152	dopamine beta-hydroxylase	Rattus norvegicus	63-88
24817036-2	2014	One of many biochemical actions of disulfiram is inhibition of dopamine beta-hydroxylase (DBH), the enzyme that converts dopamine (DA) to norepinephrine (NE) in noradrenergic neurons.	Norepinephrine	138-152	dopamine beta-hydroxylase	Rattus norvegicus	90-93
24780611-4	2014	APN intracerebroventricular infusions decreased uncoupling protein 1 (UCP1) expression in brown adipose tissue, epinephrine and norepinephrine serum levels, and osteoclast numbers, whereas osteoblast osteogenic marker expression and trabecular bone mass increased in APN-KO and WT mice.	Norepinephrine	128-142	adiponectin, C1Q and collagen domain containing	Mus musculus	0-3
24168152-1	2014	AIMS: Etamicastat is a reversible dopamine-beta-hydroxylase inhibitor that decreases noradrenaline levels in sympathetically innervated tissues and slows down sympathetic nervous system drive.	Norepinephrine	85-98	dopamine beta-hydroxylase	Homo sapiens	34-59
24607627-7	2014	We then demonstrated that MAOA suppressed norepinephrine/epinephrine (NE/E)-induced HCC invasion and anoikis inhibition, and uncovered that the effects of NE/E on HCC behaviors were primarily mediated through alpha 1A (ADRA1A) and beta 2 adrenergic receptors (ADRB2).	Norepinephrine	42-56	monoamine oxidase A	Homo sapiens	26-30
24904340-7	2014	Glutamate, serotonin, noradrenaline, and histamine are activated by stress and exert an inhibitory effect on serotonin outflow, in part by "flooding" 5-HT1A autoreceptors by serotonin itself.	Norepinephrine	22-35	5-hydroxytryptamine receptor 1A	Homo sapiens	150-156
24510409-1	2014	Monoamine oxidase A (MAOA) catalyzes monoamine neurotransmitters including dopamine, 5-hydroxytryptamine (5-HT, serotonin), and norepinephrine.	Norepinephrine	128-142	monoamine oxidase A	Homo sapiens	21-25
24333843-5	2014	Given its opiate-sensitivity and its well-characterized molecular and cellular adaptations to morphine exposure, we investigated the anatomical distribution of WLS and MOR in the rat locus coeruleus (LC)-norepinephrine (NE) system.	Norepinephrine	204-218	Wnt ligand secretion mediator	Rattus norvegicus	160-163
24599883-6	2014	Plasma norepinephrine levels positively correlated with plasma renalase levels (r = 0.64, P &lt; 0.002) as well as with urine renalase levels and activity (r = 0.47 P &lt; 0.02; r = 0.71, P &lt; 0.0005, respectively) and negatively correlated with plasma renalase activity (r = -0.57, P &lt; 0.002).	Norepinephrine	7-21	renalase, FAD dependent amine oxidase	Homo sapiens	63-71
24599883-6	2014	Plasma norepinephrine levels positively correlated with plasma renalase levels (r = 0.64, P &lt; 0.002) as well as with urine renalase levels and activity (r = 0.47 P &lt; 0.02; r = 0.71, P &lt; 0.0005, respectively) and negatively correlated with plasma renalase activity (r = -0.57, P &lt; 0.002).	Norepinephrine	7-21	renalase, FAD dependent amine oxidase	Homo sapiens	126-134
24599883-6	2014	Plasma norepinephrine levels positively correlated with plasma renalase levels (r = 0.64, P &lt; 0.002) as well as with urine renalase levels and activity (r = 0.47 P &lt; 0.02; r = 0.71, P &lt; 0.0005, respectively) and negatively correlated with plasma renalase activity (r = -0.57, P &lt; 0.002).	Norepinephrine	7-21	renalase, FAD dependent amine oxidase	Homo sapiens	126-134
24466223-10	2014	SDHx/VHL/EPAS1 associated cases had higher norepinephrine output (P = 0.03) and lower epinephrine output (P&lt;0.001) compared to RET/NF1/H-RAS cases.	Norepinephrine	43-57	endothelial PAS domain protein 1	Homo sapiens	9-14
24757681-1	2014	Neuropeptide Y was isolated from the porcine brain in 1982 and shown to be colocalized with noradrenaline in sympathetic nerve terminals.	Norepinephrine	92-105	neuropeptide Y	Homo sapiens	0-14
24297249-1	2014	We found previously that stimulation of natriuretic peptide receptor (NPR)-B by C-type natriuretic peptide (CNP) in failing rat ventricle potentiates beta1-adrenoceptor (beta1-AR)-mediated inotropic response to noradrenaline through cGMP-mediated inhibition of phosphodiesterase (PDE) 3, thereby enhancing cAMP-mediated signalling.	Norepinephrine	211-224	natriuretic peptide receptor 2	Rattus norvegicus	70-76
24297249-9	2014	We identified several small molecule NPR-B antagonists by high throughput screening and show in a functional heart preparation that blocking NPR-B stimulation with a small molecule compound can reduce the potentiating effect of CNP on the beta1-AR-mediated inotropic response to noradrenaline.	Norepinephrine	279-292	natriuretic peptide receptor 2	Rattus norvegicus	141-146
24051022-0	2013	Spinal-supraspinal and intrinsic mu-opioid receptor agonist-norepinephrine reuptake inhibitor (MOR-NRI) synergy of tapentadol in diabetic heat hyperalgesia in mice.	Norepinephrine	60-74	opioid receptor mu 1	Homo sapiens	33-51
23858446-2	2013	The combined deficiency of MAO A and B results in significantly elevated levels of serotonin (5-hydroxytryptamine), norepinephrine, dopamine, and beta-phenylethylamine; in humans and mice, these neurochemical changes are accompanied by neurodevelopmental perturbations as well as autistic-like responses.	Norepinephrine	116-130	monoamine oxidase A	Homo sapiens	27-38
23604714-4	2013	The perfusion pressure increases in isolated perfused mesenteric vascular beds in response to norepinephrine were also enhanced in CPI-17-Tg mice.	Norepinephrine	94-108	protein phosphatase 1, regulatory inhibitor subunit 14A	Mus musculus	131-137
23707643-1	2013	Many genes associated with dopamine (DA) and norepinephrine (NE) systems influence cognitive deficits of schizophrenia patients, but one key enzyme is dopamine beta-hydroxylase (DBH), which converts DA to NE and whose activity and levels are under strong genetic control.	Norepinephrine	45-59	dopamine beta-hydroxylase	Homo sapiens	151-176
23707643-1	2013	Many genes associated with dopamine (DA) and norepinephrine (NE) systems influence cognitive deficits of schizophrenia patients, but one key enzyme is dopamine beta-hydroxylase (DBH), which converts DA to NE and whose activity and levels are under strong genetic control.	Norepinephrine	45-59	dopamine beta-hydroxylase	Homo sapiens	178-181
23559427-2	2013	Dopamine beta-hydroxylase (DBH) is a key enzyme in the conversion of dopamine to norepinephrine, and plasma DBH activity is altered in TD patients.	Norepinephrine	81-95	dopamine beta-hydroxylase	Homo sapiens	0-25
23559427-2	2013	Dopamine beta-hydroxylase (DBH) is a key enzyme in the conversion of dopamine to norepinephrine, and plasma DBH activity is altered in TD patients.	Norepinephrine	81-95	dopamine beta-hydroxylase	Homo sapiens	27-30
23450051-10	2013	Although baseline PCSK9 concentrations were not associated to severity scores, PCSK9 values at day 8 were related to injury severity score (beta = 6.17; P = .0007), length of stay in ICU (beta = 6.14; P = .0001), and duration of both mechanical ventilation (beta = 8.26; P = .0001) and norepinephrine infusion (beta = 18.57; P = .015).	Norepinephrine	286-300	proprotein convertase subtilisin/kexin type 9	Homo sapiens	79-84
22883210-0	2013	Selective loss of noradrenaline exacerbates early cognitive dysfunction and synaptic deficits in APP/PS1 mice.	Norepinephrine	18-31	amyloid beta (A4) precursor protein	Mus musculus	97-104
23142129-1	2013	Peptidomic analysis of norepinephrine-stimulated skin secretions of the tetraploid clawed frog Xenopus laevis (Pipidae) led to the identification of 10 peptides with the ability to stimulate the release of insulin from the rat BRIN-BD11 clonal beta cell line.	Norepinephrine	23-37	insulin S homeolog	Xenopus laevis	206-213
23231070-5	2013	More recently, AI-3 and the host neuroendocrine (NE) hormones adrenaline and noradrenaline were reported to display cross-talk for the activation of the same signalling pathways.	Norepinephrine	77-90	family with sequence similarity 83 member H	Homo sapiens	15-19
23805714-1	2013	Peptides of the insulin superfamily (insulin, insulin-like growth factor, relaxin), epidermal.growth factor (ECF) and biogenic amines (isoproterenol, adrenalin, noradrenalin, serotonin) stimulate the adenylyl cyclase signaling system (ACSS).	Norepinephrine	161-173	epidermal growth factor	Homo sapiens	84-107
23375328-1	2013	INTRODUCTION: Renalase, an enzyme that cetabolyzes catecholamines, such as circulating adrenaline and noradrenaline, is released by the human kidney to regulate blood pressure.	Norepinephrine	102-115	renalase, FAD dependent amine oxidase	Homo sapiens	14-22
22923736-7	2012	Indeed, selective H(3) and H(4) receptor agonists each synergized with a PKG inhibitor and a PDE3 activator in attenuating BNP-induced norepinephrine release from cardiac sympathetic nerve endings.	Norepinephrine	135-149	phosphodiesterase 4D, cAMP-specific-like 1	Rattus norvegicus	93-97
26593027-1	2012	Monoamine oxidase (MAO), which exists in two isozymic forms, MAO A and MAO B, is an important flavoenzyme responsible for the metabolism of amine neurotransmitters such as dopamine, serotonin, and norepinephrine.	Norepinephrine	197-211	monoamine oxidase A	Homo sapiens	61-66
22765285-2	2012	We have typed 2 functional polymorphisms of relevance for both biosynthesis and catabolism of noradrenalin: The Val158Met single-nucleotide polymorphism (SNP) of the Catechol-O-methyl transferase gene (COMT) and the 1021C/T SNP of the dopamine dehydroxylase gene (DBH).	Norepinephrine	94-106	dopamine beta-hydroxylase	Homo sapiens	264-267
22761303-6	2012	ALDH2 activation substantially reduced acetaldehyde- and hypoxia-induced norepinephrine release, an action prevented by inhibition of ALDH2 or protein kinase Cepsilon (PKCepsilon).	Norepinephrine	73-87	aldehyde dehydrogenase 2 family member	Rattus norvegicus	0-5
22761303-6	2012	ALDH2 activation substantially reduced acetaldehyde- and hypoxia-induced norepinephrine release, an action prevented by inhibition of ALDH2 or protein kinase Cepsilon (PKCepsilon).	Norepinephrine	73-87	aldehyde dehydrogenase 2 family member	Rattus norvegicus	134-139
22761303-12	2012	This pathway comprises the sequential activation of PKCepsilon and ALDH2, culminating in aldehyde detoxification and inhibition of hypoxic norepinephrine release.	Norepinephrine	139-153	aldehyde dehydrogenase 2 family member	Rattus norvegicus	67-72
22761303-13	2012	Thus, pharmacological activation of PKCepsilon and ALDH2 in cardiac sympathetic nerves may have significant protective effects by alleviating norepinephrine-induced life-threatening arrhythmias that characterize myocardial ischemia/reperfusion.	Norepinephrine	142-156	aldehyde dehydrogenase 2 family member	Rattus norvegicus	51-56
23035305-2	2004	The human H3R gene is located on chromosome 20q13.33, and its products are expressed predominantly in the basal ganglia, hippocampus, and cortical areas, which participate in the synthesis and release of neurotransmitters (e.g., acetylcholine, dopamine, serotonin, and noradrenaline) from histaminergic neurons (2-4).	Norepinephrine	269-282	histamine receptor H3	Homo sapiens	10-13
22593004-0	2012	ATP and noradrenaline activate CREB in astrocytes via noncanonical Ca(2+)  and cyclic AMP independent pathways.	Norepinephrine	8-21	cAMP responsive element binding protein 1	Rattus norvegicus	31-35
22593004-4	2012	Here we sought to determine whether and how ATP and noradrenaline cause CREB-dependent transcription in rat cortical astrocyte cultures.	Norepinephrine	52-65	cAMP responsive element binding protein 1	Rattus norvegicus	72-76
22593004-8	2012	We conclude that ATP and noradrenaline activate CREB-dependent transcription in cortical astrocytes via an atypical protein kinase C. It is of relevance that the signaling involved be starkly different to the one described in neurons since there is no convergence of Ca(2+) and cyclic AMP-dependent pathways on CRTC, which, moreover, exerts a modulatory rather than a central role.	Norepinephrine	25-38	cAMP responsive element binding protein 1	Rattus norvegicus	48-52
22739762-2	2012	Norepinephrine is routinely administered to maintain cerebral perfusion pressure and, thereby, cerebral blood flow, but norepinephrine reduces the scO2.	Norepinephrine	120-134	synthesis of cytochrome C oxidase 2	Homo sapiens	147-151
22739762-3	2012	We hypothesized that norepinephrine-induced reduction in scO2 is influenced by cutaneous vasoconstriction.	Norepinephrine	21-35	synthesis of cytochrome C oxidase 2	Homo sapiens	57-61
22698264-5	2012	Tapentadol"s MOR agonist activity is several-fold greater than tramadol"s, with prominent norepinephrine reuptake inhibition and minimal serotonin effect.	Norepinephrine	90-104	opioid receptor mu 1	Homo sapiens	13-16
22754515-8	2012	The final study used double immunohistochemistry labeling of c-fos and dopamine beta hydroxylase (DBH), the enzyme for norepinephrine synthesis to determine if epinephrine administration alone or stimulation of the vagus nerve at an intensity identical to that which improved memory in Experiment 1 produces similar patterns of neuronal activity in brain areas involved in processing memory for emotional events.	Norepinephrine	119-133	dopamine beta-hydroxylase	Homo sapiens	98-101
22816096-3	2012	Simultaneous addition of norepinephrine and peptides into the culture potentiated the expression of AANAT and pCREB.	Norepinephrine	25-39	aralkylamine N-acetyltransferase	Rattus norvegicus	100-105
22890201-2	2012	Both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) regulate neurochemistry by degrading monoamine neurotransmitters (serotonin, dopamine, and norepinephrine).	Norepinephrine	156-170	monoamine oxidase A	Homo sapiens	5-24
22890201-2	2012	Both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) regulate neurochemistry by degrading monoamine neurotransmitters (serotonin, dopamine, and norepinephrine).	Norepinephrine	156-170	monoamine oxidase A	Homo sapiens	26-31
22426196-7	2012	Despite this unusual topography, AmAC2t-activity could be stimulated by norepinephrine and NKH477 with EC(50s) of 0.07 muM and 3 muM.	Norepinephrine	72-86	adenylate cyclase type 2	Apis mellifera	33-38
22593735-5	2012	CRH neuronal activity is largely orchestrated by three neurotransmitters: GABA, glutamate, and norepinephrine.	Norepinephrine	95-109	corticotropin releasing hormone	Homo sapiens	0-3
22899923-10	2012	The SLIT2 SNP rs1379659 and the FAM5C SNP rs1935881 were associated with norepinephrine change during exercise.	Norepinephrine	73-87	slit guidance ligand 2	Homo sapiens	4-9
22899923-11	2012	Finally, the OPRM1 SNP rs1799971 was related to changes in norepinephrine, lactate, and rate of perceived exertion (RPE) during exercise.	Norepinephrine	59-73	opioid receptor mu 1	Homo sapiens	13-18
22166418-3	2012	In this neurorescue/neurorestorative paradigm, M30 was orally administered to mice for 14 days (2.5-5 mg/kg/day) following post MPTP or lactacystin lesion and was shown to significantly elevate striatal dopamine, serotonin and noradrenaline levels, reduce their metabolism, and elevate tyrosine-hydroxylase protein levels.	Norepinephrine	227-240	olfactory receptor family 10 subfamily N member 1	Mus musculus	47-50
23029049-0	2012	Immune sculpting of norepinephrine on MHC-I, B7-1, IDO and B7-H1 expression and regulation of proliferation and invasion in pancreatic carcinoma cells.	Norepinephrine	20-34	indoleamine 2,3-dioxygenase 1	Homo sapiens	51-54
23029049-0	2012	Immune sculpting of norepinephrine on MHC-I, B7-1, IDO and B7-H1 expression and regulation of proliferation and invasion in pancreatic carcinoma cells.	Norepinephrine	20-34	CD274 molecule	Homo sapiens	59-64
21509519-1	2011	Dopamine beta-hydroxylase (DbetaH) catalyzes the conversion of dopamine to norepinephrine.	Norepinephrine	75-89	dopamine beta-hydroxylase	Homo sapiens	0-25
21943397-0	2011	CFTR mediates noradrenaline-induced ATP efflux from DRG neurons.	Norepinephrine	14-27	CF transmembrane conductance regulator	Rattus norvegicus	0-4
21943397-1	2011	In our earlier study, noradrenaline (NA) stimulated ATP release from dorsal root ganglion (DRG) neurons as mediated via beta(3) adrenoceptors linked to G(s) protein involving protein kinase A (PKA) activation, to cause allodynia.	Norepinephrine	22-35	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	175-191
21943397-1	2011	In our earlier study, noradrenaline (NA) stimulated ATP release from dorsal root ganglion (DRG) neurons as mediated via beta(3) adrenoceptors linked to G(s) protein involving protein kinase A (PKA) activation, to cause allodynia.	Norepinephrine	22-35	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	193-196
21761554-2	2011	Dopamine beta-hydroxylase (DbetaH) converts dopamine to norepinephrine, and its activity is under strong genetic control.	Norepinephrine	56-70	dopamine beta-hydroxylase	Homo sapiens	0-25
21761555-1	2011	Monoamine oxidase A (MAOA) plays a critical role in the metabolism of monoamine neurotransmitters including serotonin (5-HT), norepinephrine (NE), and dopamine (DA).	Norepinephrine	126-140	monoamine oxidase A	Homo sapiens	0-19
21761555-1	2011	Monoamine oxidase A (MAOA) plays a critical role in the metabolism of monoamine neurotransmitters including serotonin (5-HT), norepinephrine (NE), and dopamine (DA).	Norepinephrine	126-140	monoamine oxidase A	Homo sapiens	21-25
20810002-1	2011	BACKGROUND: Monoamine oxidase A (MAOA) is an important enzyme that metabolizes monoamines such as serotonin, norepinephrine and dopamine in the brain.	Norepinephrine	109-123	monoamine oxidase A	Homo sapiens	12-31
20810002-1	2011	BACKGROUND: Monoamine oxidase A (MAOA) is an important enzyme that metabolizes monoamines such as serotonin, norepinephrine and dopamine in the brain.	Norepinephrine	109-123	monoamine oxidase A	Homo sapiens	33-37
21247719-5	2011	A good linear relationship with coefficients &gt;=0.99 was achieved over the concentration ranges of 10-1000ngmL(-1) for 5-hydroxytryptamine (5-HT) and norepinephrine (NE); 2-250ngmL(-1) for methionine-enkephalin (M-ENK) and leucine-enkephalin (L-ENK).	Norepinephrine	152-166	proenkephalin	Rattus norvegicus	202-212
21247719-5	2011	A good linear relationship with coefficients &gt;=0.99 was achieved over the concentration ranges of 10-1000ngmL(-1) for 5-hydroxytryptamine (5-HT) and norepinephrine (NE); 2-250ngmL(-1) for methionine-enkephalin (M-ENK) and leucine-enkephalin (L-ENK).	Norepinephrine	152-166	proenkephalin	Rattus norvegicus	216-219
21247719-5	2011	A good linear relationship with coefficients &gt;=0.99 was achieved over the concentration ranges of 10-1000ngmL(-1) for 5-hydroxytryptamine (5-HT) and norepinephrine (NE); 2-250ngmL(-1) for methionine-enkephalin (M-ENK) and leucine-enkephalin (L-ENK).	Norepinephrine	152-166	proenkephalin	Rattus norvegicus	247-250
21525270-6	2011	We conclude that Hcrt-r2 is a vital element in a feedback loop integrating Hcrt, acetylcholine, and norepinephrine function.	Norepinephrine	100-114	hypocretin receptor 2	Canis lupus familiaris	17-24
21525270-6	2011	We conclude that Hcrt-r2 is a vital element in a feedback loop integrating Hcrt, acetylcholine, and norepinephrine function.	Norepinephrine	100-114	hypocretin neuropeptide precursor	Canis lupus familiaris	17-21
21195750-0	2011	Noradrenaline enhances ATP P2X3 receptor expression in dorsal root ganglion neurons of rats.	Norepinephrine	0-13	purinergic receptor P2X 3	Rattus norvegicus	27-31
21195750-3	2011	In the present study, we examined the effects of noradrenaline (NA) on the P2X3 receptor expression in the DRG of Sprague-Dawley rats.	Norepinephrine	49-62	purinergic receptor P2X 3	Rattus norvegicus	75-79
21572590-4	2011	More specifically, we demonstrate that noradrenaline used locally within V1 mediates the light-driven gene expression of egr-1, an immediate early gene implicated as a mediator of neuronal plasticity.	Norepinephrine	39-52	early growth response 1	Mus musculus	121-126
21156805-4	2011	The alpha(1)-adrenergic receptor agonist norepinephrine selectively activates PKD1, thrombin and PDGF selectively activate PKD2, and endothelin-1 and PMA activate both PKD1 and PKD2.	Norepinephrine	41-55	polycystin 1, transient receptor potential channel interacting	Homo sapiens	78-82
21156805-4	2011	The alpha(1)-adrenergic receptor agonist norepinephrine selectively activates PKD1, thrombin and PDGF selectively activate PKD2, and endothelin-1 and PMA activate both PKD1 and PKD2.	Norepinephrine	41-55	polycystin 1, transient receptor potential channel interacting	Homo sapiens	168-172
21129446-1	2011	Norepinephrine and serotonin involvement in nociceptive functions is supported by observations of analgesic effects of norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitors such as amitriptyline.	Norepinephrine	0-14	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Mus musculus	119-145
21297953-8	2011	Renal expression of renalase was reduced (protein: 0.476+-0.043 for control, 0.248+-0.029 for operation versus 0.636+-0.151 for sham-operation) and this was associated with an increase in circulating norepinephrine (0.168+-0.016 ng/mL for control, 0.203+-0.019 ng/mL for operation versus 0.138+-0.008 ng/mL for sham-operation).	Norepinephrine	200-214	renalase, FAD-dependent amine oxidase	Rattus norvegicus	20-28
21297953-9	2011	CONCLUSIONS/SIGNIFICANCE: Renalase expression is influenced by renal blood flow and impaired synthesis of renalase by the kidney may represent a potential mechanism underlying circulating norepinephrine accumulation in heart failure.	Norepinephrine	188-202	renalase, FAD-dependent amine oxidase	Rattus norvegicus	26-34
21297953-9	2011	CONCLUSIONS/SIGNIFICANCE: Renalase expression is influenced by renal blood flow and impaired synthesis of renalase by the kidney may represent a potential mechanism underlying circulating norepinephrine accumulation in heart failure.	Norepinephrine	188-202	renalase, FAD-dependent amine oxidase	Rattus norvegicus	106-114
20851100-2	2011	Depending upon the dose of norepinephrine (agonist) exposure, hypertrophy and apoptosis are initiated by differential induction of two discrete constituents of the transcription factor AP-1, i.e., FosB and Fra-1.	Norepinephrine	27-41	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	206-211
20800684-4	2010	In the first study, E and the ERalpha agonist increased norepinephrine in cortex and all three ER ligands increased it in the ventral hippocampus.	Norepinephrine	56-70	estrogen receptor 1	Rattus norvegicus	30-37
20728435-5	2010	A small number of HSD2 immunoreactive neurons was also labeled for dopamine-beta-hydroxylase (DBH), an enzyme involved in norepinephrine biosynthesis.	Norepinephrine	122-136	dopamine beta-hydroxylase	Rattus norvegicus	67-92
20937870-2	2010	During the fight-or-flight response, epinephrine released by the adrenal medulla and norepinephrine released from sympathetic nerves increase muscle contractility by activation of the beta-adrenergic receptor/cAMP-dependent protein kinase pathway and up-regulation of Ca(V)1 channels in skeletal and cardiac muscle.	Norepinephrine	85-99	caveolin-1	Oryctolagus cuniculus	268-274
20600439-5	2010	In both cases, the effect on norepinephrine uptake was coupled to protein kinase A and C as well as nitric oxide pathways.	Norepinephrine	29-43	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	66-82
20810904-6	2010	Norepinephrine and isoproterenol upregulated the expression of Abeta receptor mFPR2, a mouse homolog of human formyl peptide receptor FPR2, through activation of beta(2)AR in microglia.	Norepinephrine	0-14	formyl peptide receptor 2	Homo sapiens	79-83
20554938-3	2010	Expression of c-Fos protein was used as a marker for neuronal activation and dopamine-beta-hydroxylase (DBH), the enzyme-catalyzing noradrenaline synthesis, as a marker for noradrenergic neurons.	Norepinephrine	132-145	dopamine beta-hydroxylase	Rattus norvegicus	104-107
20170659-7	2010	Short interfering RNA targeting XBP1 suppressed the induction of BNP expression by a pharmacological ER stressor or norepinephrine, which was rescued by the adenovirus-mediated overexpression of sXBP1.	Norepinephrine	116-130	X-box binding protein 1	Homo sapiens	32-36
20351116-7	2010	At 4 weeks post-MI, plasma levels of both norepinephrine and epinephrine were reduced in PNMT-driven GRK2 KO, compared with control mice, suggesting markedly reduced post-MI sympathetic activation.	Norepinephrine	42-56	G protein-coupled receptor kinase 2	Mus musculus	101-105
20193756-0	2010	Noradrenaline acting at central beta-adrenoceptors induces interleukin-10 and suppressor of cytokine signaling-3 expression in rat brain: implications for neurodegeneration.	Norepinephrine	0-13	interleukin 10	Rattus norvegicus	59-112
20193756-3	2010	Administration of the noradrenaline reuptake inhibitor reboxetine (15mg/kg; ip) combined with the alpha(2)-adrenoceptor antagonist idazoxan (1mg/kg; ip) induced interleukin-10 (IL-10) expression in rat cortex and hippocampus.	Norepinephrine	22-35	interleukin 10	Rattus norvegicus	161-175
20193756-3	2010	Administration of the noradrenaline reuptake inhibitor reboxetine (15mg/kg; ip) combined with the alpha(2)-adrenoceptor antagonist idazoxan (1mg/kg; ip) induced interleukin-10 (IL-10) expression in rat cortex and hippocampus.	Norepinephrine	22-35	interleukin 10	Rattus norvegicus	177-182
20132473-0	2010	Regulation of MCP-1 production in brain by stress and noradrenaline-modulating drugs.	Norepinephrine	54-67	C-C motif chemokine ligand 2	Rattus norvegicus	14-19
20086041-12	2010	Interestingly, KL-shRNA increased brain ET1 expression and plasma norepinephrine level, suggesting that silencing of brain klotho increased ET1 production and the sympathetic nervous activity.	Norepinephrine	66-80	Klotho	Rattus norvegicus	123-129
20525314-6	2010	With synovial cell-culture experiments and ELISA, effects of norepinephrine, TNF, and cortisol on HNP1-3 were detected.	Norepinephrine	61-75	HNP1	Homo sapiens	98-104
20525314-10	2010	Norepinephrine dose-dependently decreased HNP1-3 levels from RA and OA cells.	Norepinephrine	0-14	HNP1	Homo sapiens	42-48
20525314-14	2010	CONCLUSIONS: This study demonstrated an inhibitory effect of norepinephrine on HNP1-3 of mixed synovial cells.	Norepinephrine	61-75	HNP1	Homo sapiens	79-85
20525314-15	2010	In light of these findings, the loss of sympathetic nerve fibers with low resting norepinephrine levels might also augment the inflammatory process through HNP1-3.	Norepinephrine	82-96	HNP1	Homo sapiens	156-162
23675164-1	2009	Dopamine-beta-hydroxylase (DBH) is a neurotransmitter synthesizing enzyme which catalyzes the formation of norepinephrine from dopamine.	Norepinephrine	107-121	dopamine beta-hydroxylase	Homo sapiens	0-25
23675164-1	2009	Dopamine-beta-hydroxylase (DBH) is a neurotransmitter synthesizing enzyme which catalyzes the formation of norepinephrine from dopamine.	Norepinephrine	107-121	dopamine beta-hydroxylase	Homo sapiens	27-30
19693491-19	2009	Both PDE3 and PDE4 control atrial and ventricular positive inotropic effects of (-)-noradrenaline.	Norepinephrine	80-97	phosphodiesterase 4D, cAMP-specific-like 1	Rattus norvegicus	5-9
19615672-5	2009	Plasma MAOA dependent metabolites of norepinephrine: dihydroxyphenylglycol; dopamine: homovanillic and dihydroxyphenylacetic acid; and serotonin: 5-hydroxy-indol acetic acid were measured at the end of the second trimester, at delivery, and in arterial cord blood along with plasma cotinine.	Norepinephrine	37-51	monoamine oxidase A	Homo sapiens	7-11
19470703-2	2009	Here we report Sik1 expression was induced by norepinephrine (NE) in rat pinealocytes primarily through activation of beta-adrenergic receptors, with a minor contribution from activation of alpha-adrenergic receptors.	Norepinephrine	46-60	salt-inducible kinase 1	Rattus norvegicus	15-19
19672024-5	2009	RESULTS: In pheochromocytoma tissue, AdpR1 mRNA expression was higher in adrenaline (A)-type tumors than in noradrenaline (NA)-type tumors.	Norepinephrine	108-121	adiponectin receptor 1	Homo sapiens	37-42
19079842-1	2009	Cu is an essential cofactor for at least twelve mammalian enzymes including dopamine beta-mono-oxygenase (DBM), which converts dopamine (DA) to noradrenaline (NA).	Norepinephrine	144-157	dopamine beta-hydroxylase	Rattus norvegicus	76-104
19345680-4	2009	In particular, noradrenaline (NA) is required for late-LTP in the dentate gyrus and dopamine for late-LTP in the apical CA1-dendrites.	Norepinephrine	15-28	carbonic anhydrase 1	Rattus norvegicus	120-123
19356247-4	2009	NET function in adult noradrenergic neurons of the peripheral and central nervous systems is to internalize norepinephrine from the synaptic cleft.	Norepinephrine	108-122	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Mus musculus	0-3
19374850-12	2009	These results suggest that centrally administered epibatidine activates the brain nicotinic acethylcholine receptors, thereby evoking the secretion of noradrenaline and adrenaline from the adrenal medulla by brain cyclooxygenase- and prostanoid TP receptor-mediated mechanisms in rats.	Norepinephrine	151-164	thromboxane A2 receptor	Rattus norvegicus	214-256
19120146-9	2008	Positive association was found between baseline concentrations of norepinephrine and PAI-1 (r= 0.418, P= 0.02).	Norepinephrine	66-80	serpin family E member 1	Homo sapiens	85-90
18418364-4	2008	Reduced NET expression resulted in reduced norepinephrine uptake, measured in vitro, and increased noradrenergic neurotransmission, measured in vivo using microdialysis.	Norepinephrine	43-57	solute carrier family 6 member 2	Rattus norvegicus	8-11
18706965-0	2008	Antimicrobial action of histone H2B in Escherichia coli: evidence for membrane translocation and DNA-binding of a histone H2B fragment after proteolytic cleavage by outer membrane proteinase T. Previous studies have led to the isolation of histone H2B with antibacterial properties from an extract of the skin of the Schlegel"s green tree frog Rhacophorus schlegelii and it is now demonstrated that the intact peptide is released into norepinephrine-stimulated skin secretions.	Norepinephrine	435-449	H2B clustered histone 21	Homo sapiens	32-35
18706965-0	2008	Antimicrobial action of histone H2B in Escherichia coli: evidence for membrane translocation and DNA-binding of a histone H2B fragment after proteolytic cleavage by outer membrane proteinase T. Previous studies have led to the isolation of histone H2B with antibacterial properties from an extract of the skin of the Schlegel"s green tree frog Rhacophorus schlegelii and it is now demonstrated that the intact peptide is released into norepinephrine-stimulated skin secretions.	Norepinephrine	435-449	H2B clustered histone 21	Homo sapiens	122-125
18706965-0	2008	Antimicrobial action of histone H2B in Escherichia coli: evidence for membrane translocation and DNA-binding of a histone H2B fragment after proteolytic cleavage by outer membrane proteinase T. Previous studies have led to the isolation of histone H2B with antibacterial properties from an extract of the skin of the Schlegel"s green tree frog Rhacophorus schlegelii and it is now demonstrated that the intact peptide is released into norepinephrine-stimulated skin secretions.	Norepinephrine	435-449	H2B clustered histone 21	Homo sapiens	122-125
18981694-1	2008	Catecholamines, namely, dopamine, norepinephrine and epinephrine, play important roles in higher animals as neurotransmitters or hormones, and are metabolized by catechol-O-methyltransferase (COMT).	Norepinephrine	34-48	catechol-O-methyltransferase	Rattus norvegicus	162-190
18981694-1	2008	Catecholamines, namely, dopamine, norepinephrine and epinephrine, play important roles in higher animals as neurotransmitters or hormones, and are metabolized by catechol-O-methyltransferase (COMT).	Norepinephrine	34-48	catechol-O-methyltransferase	Rattus norvegicus	192-196
18638525-0	2008	Distinct regulation of brain-derived neurotrophic factor and noradrenaline in S100B knockout mice.	Norepinephrine	61-74	S100 protein, beta polypeptide, neural	Mus musculus	78-83
18800308-4	2008	An intracerebroventricular injection of leptin attenuated the increases in hypothalamic noradrenaline release and plasma ACTH concentrations after FSs, while ghrelin augmented these responses.	Norepinephrine	88-101	leptin	Homo sapiens	40-46
18800308-5	2008	These data suggest that leptin inhibits and ghrelin facilitates neuroendocrine stress responses via noradrenaline release and indicate that a decrease in leptin and an increase in ghrelin release after food deprivation might contribute to augmentation of stress-induced ACTH release in a fasting state.	Norepinephrine	100-113	leptin	Homo sapiens	24-30
18480676-3	2008	Among these are several genes associated with the catecholaminergic system including the dopamine receptor genes (DRD4 and DRD5), the dopamine transporter gene, and the gene for dopamine beta-hydroxylase, which catalyzes conversion of dopamine to norepinephrine.	Norepinephrine	247-261	dopamine receptor D4	Homo sapiens	114-118
18480676-3	2008	Among these are several genes associated with the catecholaminergic system including the dopamine receptor genes (DRD4 and DRD5), the dopamine transporter gene, and the gene for dopamine beta-hydroxylase, which catalyzes conversion of dopamine to norepinephrine.	Norepinephrine	247-261	dopamine beta-hydroxylase	Homo sapiens	178-203
18463263-1	2008	The genetic deletion of monoamine oxidase A (MAO A), an enzyme that breaks down the monoamine neurotransmitters norepinephrine, serotonin, and dopamine, produces aggressive phenotypes across species.	Norepinephrine	112-126	monoamine oxidase A	Homo sapiens	24-43
18463263-1	2008	The genetic deletion of monoamine oxidase A (MAO A), an enzyme that breaks down the monoamine neurotransmitters norepinephrine, serotonin, and dopamine, produces aggressive phenotypes across species.	Norepinephrine	112-126	monoamine oxidase A	Homo sapiens	45-50
18177483-13	2008	We conclude that noradrenaline-induced increases in the expression of NHE-3, NBC-1, BSC-1 and aquaporin-2 are likely to play an important role in the regulation of salt and water transport by noradrenaline in the kidney and may explain, at least in part, the altered renal sodium and water handling associated with overactivation of the sympathetic system.	Norepinephrine	192-205	aquaporin 2	Rattus norvegicus	94-105
18278799-7	2008	We also used immunocytochemistry to assess these areas for immunoreactive dopamine-beta-hydroxylase (DBH-ir), the enzyme that synthesizes norepinephrine.	Norepinephrine	138-152	dopamine beta-hydroxylase	Sturnus vulgaris	74-99
18278799-7	2008	We also used immunocytochemistry to assess these areas for immunoreactive dopamine-beta-hydroxylase (DBH-ir), the enzyme that synthesizes norepinephrine.	Norepinephrine	138-152	dopamine beta-hydroxylase	Sturnus vulgaris	101-104
18194185-5	2008	MAIN OUTCOME MEASURE: Both spontaneous myogenic activity and contractile responses to field stimulation, norepinephrine, histamine, and endothelin-1 were reduced by ClC blockers.	Norepinephrine	105-119	cystic fibrosis transmembrane conductance regulator	Oryctolagus cuniculus	165-168
17884271-5	2008	The present results suggest that high-activity MAO-A genotypes possibly by consecutively decreased serotonin and/or norepinephrine availability negatively influence antidepressant treatment response during the first six weeks of pharmacological treatment in female patients with Major Depression.	Norepinephrine	116-130	monoamine oxidase A	Homo sapiens	47-52
17978496-4	2007	COMT activities were assessed by measuring normetanephrine with the use of norepinephrine as an endogenous substrate.	Norepinephrine	75-89	catechol-O-methyltransferase	Rattus norvegicus	0-4
17951539-1	2007	To examine whether norepinephrine, through activation of alpha1b-adrenergic receptor, regulates male fertility and testicular functions, we used alpha1b-adrenergic receptor knockout (alpha1b-AR-KO) mice.	Norepinephrine	19-33	adrenergic receptor, alpha 1b	Mus musculus	57-84
17507294-13	2007	This observation may depend on altered coupling between electrical nerve activity and norepinephrine release and/or a changed norepinephrine uptake in RGS2-/- mice.	Norepinephrine	126-140	regulator of G-protein signaling 2	Mus musculus	151-155
17868372-6	2007	Dopamine beta hydroxylase staining was used to confirm N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine-depleted terminal norepinephrine levels.	Norepinephrine	118-132	dopamine beta-hydroxylase	Rattus norvegicus	0-25
17625104-2	2007	Norepinephrine is synthesized from dopamine by dopamine-beta-hydroxylase (DBH).	Norepinephrine	0-14	dopamine beta-hydroxylase	Homo sapiens	47-72
17625104-2	2007	Norepinephrine is synthesized from dopamine by dopamine-beta-hydroxylase (DBH).	Norepinephrine	0-14	dopamine beta-hydroxylase	Homo sapiens	74-77
17625104-9	2007	High DBH in POTS was linked to elevated plasma levels of norepinephrine.	Norepinephrine	57-71	dopamine beta-hydroxylase	Homo sapiens	5-8
17394554-0	2007	Noradrenaline enhances the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of PI3K/Akt and the mTOR/S6K pathway.	Norepinephrine	0-13	solute carrier family 16 member 7	Homo sapiens	82-86
17394554-1	2007	Monocarboxylate transporter 2 (MCT2) expression is up-regulated by noradrenaline (NA) in cultured cortical neurons via a putative but undetermined translational mechanism.	Norepinephrine	67-80	solute carrier family 16 member 7	Homo sapiens	0-29
17394554-1	2007	Monocarboxylate transporter 2 (MCT2) expression is up-regulated by noradrenaline (NA) in cultured cortical neurons via a putative but undetermined translational mechanism.	Norepinephrine	67-80	solute carrier family 16 member 7	Homo sapiens	31-35
17429057-9	2007	Indeed, K(+)-induced norepinephrine exocytosis from cardiac synaptosomes was potentiated in PAI-1(-/-), attenuated in t-PA(-/-) and not different from WT in u-PA(-/-) and plgn(-/-) mice.	Norepinephrine	21-35	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	92-97
17429342-0	2007	Modulation of angiotensin II and norepinephrine-induced plasminogen activator inhibitor-1 expression by AT1a receptor deficiency.	Norepinephrine	33-47	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	56-89
17429342-8	2007	Norepinephrine increased PAI-1 expression in WT heart and aorta, and in AT(1a)-/- heart, kidney, and liver with no effect of losartan.	Norepinephrine	0-14	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	25-30
17429342-11	2007	Further, norepinephrine induces PAI-1 expression in vivo with AT(1a) receptor deficiency modulating the effect.	Norepinephrine	9-23	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	32-37
17394158-9	2007	Our results extend current knowledge about noradrenergic projections to specialized nuclei of the song control circuit and provide neuroanatomical evidence for the functional action of norepinephrine-modulating context-dependent ZENK expression in area X.	Norepinephrine	185-199	early growth response protein 1	Taeniopygia guttata	229-233
17417058-1	2007	OBJECTIVE: Monoamine oxidase A is a mitochondrial enzyme involved in the degradation of certain neurotransmitter amines: serotonin and norepinephrine.	Norepinephrine	135-149	monoamine oxidase A	Homo sapiens	11-30
17585061-2	2007	The monoamine oxidase-A (MAOA) gene, which plays a vital role in degradation of neurotransmitters such as serotonin, norepinephrine, and dopamine, contains a polymorphism in its promoter region (MAOA-uVNTR) that affects transcriptional efficiency.	Norepinephrine	117-131	monoamine oxidase A	Homo sapiens	4-23
17585061-2	2007	The monoamine oxidase-A (MAOA) gene, which plays a vital role in degradation of neurotransmitters such as serotonin, norepinephrine, and dopamine, contains a polymorphism in its promoter region (MAOA-uVNTR) that affects transcriptional efficiency.	Norepinephrine	117-131	monoamine oxidase A	Homo sapiens	25-29
17585061-2	2007	The monoamine oxidase-A (MAOA) gene, which plays a vital role in degradation of neurotransmitters such as serotonin, norepinephrine, and dopamine, contains a polymorphism in its promoter region (MAOA-uVNTR) that affects transcriptional efficiency.	Norepinephrine	117-131	monoamine oxidase A	Homo sapiens	195-199
17514581-3	2007	Furthermore, we observed that gene expression of GCH in the locus coeruleus (LC) in mice was enhanced by peripheral administration of LPS, resulting in increased concentrations of BH4, and norepinephrine, and its metabolite 4-hydroxy-3-methoxyphenylglycol (MHPG).	Norepinephrine	189-203	GTP cyclohydrolase 1	Mus musculus	49-52
17514581-4	2007	These results suggest that tyrosine hydroxylase (TH) activity is increased by increased content of BH4 due to enhanced mRNA expression of GCH in the LC resulting in the increase in norepinephrine in the LC during endotoxemia.	Norepinephrine	181-195	GTP cyclohydrolase 1	Mus musculus	138-141
17485013-1	2007	BACKGROUND: The aim of the present study was to evaluate the intervention of COX-1- and COX-2-derived prostaglandins in the responses of human gastroepiploic artery to sympathetic stimulation and norepinephrine.	Norepinephrine	196-210	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	77-82
17303090-2	2007	The control of GnRH secretion depends on several neurotransmitters, such as serotonin (5-HT), noradrenaline (NA), dopamine (DA) and nitric oxide (NO).	Norepinephrine	94-107	gonadotropin releasing hormone 1	Rattus norvegicus	15-19
17439480-3	2007	We previously showed that the Mecp2-deficient mice, a mouse model of RS, have highly variable respiratory rhythm and frequent apneas due to reduced norepinephrine (NE) content, and a drastic decrease of tyrosine hydroxylase (TH)-expressing neurons in the medulla.	Norepinephrine	148-162	methyl CpG binding protein 2	Mus musculus	30-35
17318500-0	2007	The effects of both noradrenaline and CGP12177, mediated through human beta1 -adrenoceptors, are reduced by PDE3 in human atrium but PDE4 in CHO cells.	Norepinephrine	20-33	phosphodiesterase 4D, cAMP-specific-like 1	Rattus norvegicus	108-112
17318500-9	2007	PDE3, but not PDE4, blunts the positive inotropic effects of both (-)-noradrenaline and (-)-CGP12177 through H and L sites, respectively, of human atrial beta1 -adrenoceptors.	Norepinephrine	66-83	phosphodiesterase 4D, cAMP-specific-like 1	Rattus norvegicus	0-4
17328795-3	2007	Monoamine oxidase A (MAO-A) encodes an enzyme that degrades biogenic amines, including neurotransmitters such as norepinephrine, dopamine and serotonin.	Norepinephrine	113-127	monoamine oxidase A	Homo sapiens	0-19
17328795-3	2007	Monoamine oxidase A (MAO-A) encodes an enzyme that degrades biogenic amines, including neurotransmitters such as norepinephrine, dopamine and serotonin.	Norepinephrine	113-127	monoamine oxidase A	Homo sapiens	21-26
17079074-4	2007	In contrast, treatment with proteasome inhibitors increased norepinephrine-stimulated MKP-1 protein levels and abolished the decline in norepinephrine-stimulated MKP-1 protein levels caused by inhibition of transcription or translation, or blockade of alpha-adrenergic receptors.	Norepinephrine	60-74	dual specificity phosphatase 1	Rattus norvegicus	86-91
17079074-4	2007	In contrast, treatment with proteasome inhibitors increased norepinephrine-stimulated MKP-1 protein levels and abolished the decline in norepinephrine-stimulated MKP-1 protein levels caused by inhibition of transcription or translation, or blockade of alpha-adrenergic receptors.	Norepinephrine	136-150	dual specificity phosphatase 1	Rattus norvegicus	162-167
17187001-4	2006	Dopamine-beta-hydroxylase (DBH) is an enzyme responsible for the conversion of dopamine into noradrenaline.	Norepinephrine	93-106	dopamine beta-hydroxylase	Homo sapiens	0-25
17187001-4	2006	Dopamine-beta-hydroxylase (DBH) is an enzyme responsible for the conversion of dopamine into noradrenaline.	Norepinephrine	93-106	dopamine beta-hydroxylase	Homo sapiens	27-30
17041759-0	2006	Norepinephrine induces apoptosis in neonatal rat endothelial cells via a ROS-dependent JNK activation pathway.	Norepinephrine	0-14	mitogen-activated protein kinase 8	Rattus norvegicus	87-90
17088501-2	2006	Monoamine oxidase A (MAO-A) is an enzyme that metabolizes monoamines, such as serotonin, norepinephrine, and dopamine.	Norepinephrine	89-103	monoamine oxidase A	Homo sapiens	0-19
17088501-2	2006	Monoamine oxidase A (MAO-A) is an enzyme that metabolizes monoamines, such as serotonin, norepinephrine, and dopamine.	Norepinephrine	89-103	monoamine oxidase A	Homo sapiens	21-26
16824047-0	2006	Abnormal compartmentalization of norepinephrine in mouse dentate gyrus in alpha-synuclein knockout and A30P transgenic mice.	Norepinephrine	33-47	synuclein, alpha	Mus musculus	74-89
16824047-3	2006	We also found that alpha-synuclein, a presynaptic protein that plays a crucial role in dopamine compartmentalization in the striatum, is also involved in the compartmentalization of norepinephrine in the dentate gyrus.	Norepinephrine	182-196	synuclein, alpha	Mus musculus	19-34
16824047-5	2006	Addition of mutated human alpha-synuclein abolished the normal norepinephrine mobilization.	Norepinephrine	63-77	synuclein alpha	Homo sapiens	26-41
17014691-4	2006	Here we analyzed the effect of tumor necrosis factor-alpha (TNF-alpha) and corticosterone on the transcription of the Aa-nat, hiomt and 14-3-3 protein genes in denervated pineal glands of rats stimulated for 5 hr with norepinephrine, using real-time reverse transcription-polymerase chain reaction.	Norepinephrine	218-232	aralkylamine N-acetyltransferase	Rattus norvegicus	118-142
17014691-8	2006	In addition, corticosterone induced a potentiation of norepinephrine-induced Aa-nat transcription even after 48 hr of incubation.	Norepinephrine	54-68	aralkylamine N-acetyltransferase	Rattus norvegicus	77-83
16770335-2	2006	Monoamine oxidase A deaminates the monoamine neurotransmitters serotonin, dopamine (DA), and noradrenaline.	Norepinephrine	93-106	monoamine oxidase A	Homo sapiens	0-19
16893419-2	2006	Interestingly, in GATA-3-/- mice, noradrenaline (NA) deficiency is a proximal cause of embryonic lethality.	Norepinephrine	34-47	GATA binding protein 3	Mus musculus	18-24
16725119-2	2006	Norepinephrine is degraded by monoamine oxidase A (MAOA) and catechol-O-methyl transferase (COMT).	Norepinephrine	0-14	monoamine oxidase A	Homo sapiens	30-49
16725119-2	2006	Norepinephrine is degraded by monoamine oxidase A (MAOA) and catechol-O-methyl transferase (COMT).	Norepinephrine	0-14	monoamine oxidase A	Homo sapiens	51-55
16510159-6	2006	In particular, central catecholamine depletion, dexmedetomidine-induced inhibition of noradrenaline release and blockade of alpha(1)-adrenoceptors with prazosin, up-regulated CYP1A2 expression.	Norepinephrine	86-99	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	175-181
16442134-6	2006	Interestingly, sex-specific alterations in neurochemical levels were detected, including elevated noradrenaline and reduced glutamate levels in striatum of Wa-1 males, increased noradrenaline and reduced serotonin metabolite levels in hippocampus of Wa-1 females, reduced serotonin metabolite levels in cortex and amygdala of Wa-1 females, and reduced noradrenaline, dopamine, serotonin, glutamate and glycine levels in hypothalamus of Wa-1 females compared to their respective controls.	Norepinephrine	98-111	transforming growth factor alpha	Mus musculus	156-160
16154248-3	2006	In addition, all three proteins are required for l-norepinephrine-facilitated iron uptake from transferrin as judged by failure of a fepA iroN cir triple mutant to grow in serum-containing medium in the presence of l-norepinephrine.	Norepinephrine	49-65	circling	Mus musculus	143-146
16513451-2	2006	ET-1, angiotensin II, and norepinephrine act via G protein-coupled receptors with a possible involvement of the G-protein beta3 subunit (GNB3) C825T polymorphism.	Norepinephrine	26-40	G protein subunit beta 3	Homo sapiens	112-127
16513451-2	2006	ET-1, angiotensin II, and norepinephrine act via G protein-coupled receptors with a possible involvement of the G-protein beta3 subunit (GNB3) C825T polymorphism.	Norepinephrine	26-40	G protein subunit beta 3	Homo sapiens	137-141
16462018-6	2006	COMT activities were assessed by measuring normetanephrine with the use of norepinephrine as an endogenous substrate.	Norepinephrine	75-89	catechol-O-methyltransferase	Rattus norvegicus	0-4
16687308-3	2006	At the beginning of the night, norepinephrine (NE) elicits a rapid and sustained phosphorylation of CREB into pCREB and a transient synthesis of the immediate early gene products c-FOS and c-JUN that peak 3 h after dark onset.	Norepinephrine	31-45	cAMP responsive element binding protein 1	Rattus norvegicus	100-104
16687309-2	2006	Studies with proteasome inhibitors, MG132 and clasto-lactacystin beta-lactone (c-lact), show two opposite effects of proteasomal inhibition on norepinephrine (NE)-induction of Aanat.	Norepinephrine	143-157	aralkylamine N-acetyltransferase	Rattus norvegicus	176-181
16166080-2	2005	Norepinephrine binds to the beta-adrenergic receptor and stimulates an increase in intracellular cAMP levels, leading to the transcriptional activation of serotonin N-acetyltransferase, which in turn promotes melatonin production.	Norepinephrine	0-14	aralkylamine N-acetyltransferase	Rattus norvegicus	155-184
16171784-0	2005	Norepinephrine but not hypoxia stimulates HIF-1alpha gene expression in brown adipocytes.	Norepinephrine	0-14	hypoxia inducible factor 1, alpha subunit	Mus musculus	42-52
16171784-2	2005	In the present study, the sympathetically controlled brown adipose tissue was used to investigate the effect of norepinephrine on HIF-1alpha gene expression.	Norepinephrine	112-126	hypoxia inducible factor 1, alpha subunit	Mus musculus	130-140
16171784-3	2005	Norepinephrine increased HIF-1alpha mRNA levels in cultured brown adipocytes, whereas the hypoxia-mimic cobalt was without effect.	Norepinephrine	0-14	hypoxia inducible factor 1, alpha subunit	Mus musculus	25-35
16171784-6	2005	These results demonstrate that cold-induced HIF-1alpha gene expression is independent of thermogenic oxygen consumption leading to hypoxia, but is consistent with a norepinephrine regulation of HIF-1alpha gene expression.	Norepinephrine	165-179	hypoxia inducible factor 1, alpha subunit	Mus musculus	194-204
16171784-7	2005	Thus, by elevating HIF-1alpha gene expression, norepinephrine may mediate an increased potential to respond to hypoxia in brown adipose tissue and possibly in other tissues.	Norepinephrine	47-61	hypoxia inducible factor 1, alpha subunit	Mus musculus	19-29
16051698-6	2005	Isoprenaline, noradrenaline, and adrenaline (-log EC(50) = 5.9, 5.5, and 5.7, respectively) stimulated an association between the beta(2)-adrenoceptor and beta-arrestin 2 at much higher concentrations than required for activation of cAMP accumulation (-log EC(50) = 7.6, 6.3, and 7.7, respectively).	Norepinephrine	14-27	adrenergic receptor, beta 2	Mus musculus	130-150
16051698-6	2005	Isoprenaline, noradrenaline, and adrenaline (-log EC(50) = 5.9, 5.5, and 5.7, respectively) stimulated an association between the beta(2)-adrenoceptor and beta-arrestin 2 at much higher concentrations than required for activation of cAMP accumulation (-log EC(50) = 7.6, 6.3, and 7.7, respectively).	Norepinephrine	14-27	arrestin, beta 2	Mus musculus	155-170
16127244-4	2005	Depletion of central noradrenaline by 6-hydroxydopamine abolished the depressant effect of tizanidine on the MSR almost completely and attenuated the effect on the DSR.	Norepinephrine	21-34	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Rattus norvegicus	109-112
15939797-0	2005	Norepinephrine induces lipolysis in beta1/beta2/beta3-adrenoceptor knockout mice.	Norepinephrine	0-14	hemoglobin, beta adult major chain	Mus musculus	36-41
15939797-0	2005	Norepinephrine induces lipolysis in beta1/beta2/beta3-adrenoceptor knockout mice.	Norepinephrine	0-14	adrenergic receptor, beta 3	Mus musculus	48-66
15939797-2	2005	Norepinephrine and epinephrine act through three subtypes of beta-adrenoceptors (beta-AR) expressed in the adipocytes.	Norepinephrine	0-14	adrenergic receptor, beta 3	Mus musculus	81-88
15936529-2	2005	Noradrenaline (NA) is catabolized by monoamine oxidase A (MAOA) and cathecol-O-methyl transferase (COMT).	Norepinephrine	0-13	monoamine oxidase A	Homo sapiens	37-56
15936529-2	2005	Noradrenaline (NA) is catabolized by monoamine oxidase A (MAOA) and cathecol-O-methyl transferase (COMT).	Norepinephrine	0-13	monoamine oxidase A	Homo sapiens	58-62
15949713-0	2005	Gut-derived norepinephrine plays an important role in up-regulating IL-1beta and IL-10.	Norepinephrine	12-26	interleukin 10	Rattus norvegicus	81-86
15809070-5	2005	Treatment with Ucn 2 increased noradrenaline secretion and induced phosphorylation of PKA and Erk1/2.	Norepinephrine	31-44	urocortin 2	Rattus norvegicus	15-20
15809070-9	2005	Thus, Ucn 2 induces noradrenaline secretion and TH phosphorylation through the PKA pathway and the PKA-Erk1/2 pathway, respectively.	Norepinephrine	20-33	urocortin 2	Rattus norvegicus	6-11
15647328-0	2005	Ectonucleoside triphosphate diphosphohydrolase 1/CD39, localized in neurons of human and porcine heart, modulates ATP-induced norepinephrine exocytosis.	Norepinephrine	126-140	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	0-48
15647328-0	2005	Ectonucleoside triphosphate diphosphohydrolase 1/CD39, localized in neurons of human and porcine heart, modulates ATP-induced norepinephrine exocytosis.	Norepinephrine	126-140	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	49-53
15647328-1	2005	Using a guinea pig heart synaptosomal preparation, we previously observed that norepinephrine (NE) exocytosis was attenuated by a blockade of P2X purinoceptors, potentiated by inhibition of ectonucleoside triphosphate diphosphohydrolase-1 (E-NTPDase1)/CD39, and reduced by soluble CD39, a recombinant form of human E-NTPDase1/CD39.	Norepinephrine	79-93	ectonucleoside triphosphate diphosphohydrolase 1	Cavia porcellus	190-238
15647328-1	2005	Using a guinea pig heart synaptosomal preparation, we previously observed that norepinephrine (NE) exocytosis was attenuated by a blockade of P2X purinoceptors, potentiated by inhibition of ectonucleoside triphosphate diphosphohydrolase-1 (E-NTPDase1)/CD39, and reduced by soluble CD39, a recombinant form of human E-NTPDase1/CD39.	Norepinephrine	79-93	ectonucleoside triphosphate diphosphohydrolase 1	Cavia porcellus	240-250
15647328-1	2005	Using a guinea pig heart synaptosomal preparation, we previously observed that norepinephrine (NE) exocytosis was attenuated by a blockade of P2X purinoceptors, potentiated by inhibition of ectonucleoside triphosphate diphosphohydrolase-1 (E-NTPDase1)/CD39, and reduced by soluble CD39, a recombinant form of human E-NTPDase1/CD39.	Norepinephrine	79-93	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	252-256
15627480-8	2005	Both, reduced noradrenaline release in central nervous system induced with dexmedetomidine and central catecholamine depletion, as well as blockade of central alpha1-adrenoceptors induced with prazosin, all were associated with up-regulation of CYP1A1 expression.	Norepinephrine	14-27	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	245-251
15619008-5	2005	In contrast, spontaneous tumor cell migration is largely independent of non-muscle myosin II activity, whereas the norepinephrine-induced migration is completely inhibited by either direct inhibition of non-muscle myosin II or of the kinases phosphorylating the myosin light chain, namely ROCK or the calcium/calmodulin-dependent myosin light-chain kinase.	Norepinephrine	115-129	myosin heavy chain 14	Homo sapiens	214-220
15619008-5	2005	In contrast, spontaneous tumor cell migration is largely independent of non-muscle myosin II activity, whereas the norepinephrine-induced migration is completely inhibited by either direct inhibition of non-muscle myosin II or of the kinases phosphorylating the myosin light chain, namely ROCK or the calcium/calmodulin-dependent myosin light-chain kinase.	Norepinephrine	115-129	myosin heavy chain 14	Homo sapiens	214-220
15619008-5	2005	In contrast, spontaneous tumor cell migration is largely independent of non-muscle myosin II activity, whereas the norepinephrine-induced migration is completely inhibited by either direct inhibition of non-muscle myosin II or of the kinases phosphorylating the myosin light chain, namely ROCK or the calcium/calmodulin-dependent myosin light-chain kinase.	Norepinephrine	115-129	myosin heavy chain 14	Homo sapiens	214-220
15813642-5	2005	In addition, the SP/NK1R system shows significant spatial overlap with neurotransmitters such as serotonin and noradrenaline (norepinephrine), which are known to be involved in the regulation of stress, mood and anxiety.	Norepinephrine	111-124	tachykinin receptor 1	Homo sapiens	20-24
15813642-5	2005	In addition, the SP/NK1R system shows significant spatial overlap with neurotransmitters such as serotonin and noradrenaline (norepinephrine), which are known to be involved in the regulation of stress, mood and anxiety.	Norepinephrine	126-140	tachykinin receptor 1	Homo sapiens	20-24
15990460-1	2005	Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine and these neurotransmitters are hypothesized to be involved in the cognitive function of humans.	Norepinephrine	108-122	monoamine oxidase A	Homo sapiens	0-19
15990460-1	2005	Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine and these neurotransmitters are hypothesized to be involved in the cognitive function of humans.	Norepinephrine	108-122	monoamine oxidase A	Homo sapiens	21-25
15796803-3	2005	The dopamine beta hydroxylase (DbetaH) is the key enzyme to ADHD since it catalyzes the conversion of dopamine to norepinephrine, and dysfunction there of is believed to be one of the causes of the disorder.	Norepinephrine	114-128	dopamine beta-hydroxylase	Homo sapiens	4-29
15569098-0	2004	Reduced sympathetic responsiveness as well as plasma and tissue noradrenaline concentration in growth hormone transgenic mice.	Norepinephrine	64-77	growth hormone	Mus musculus	95-109
15447813-1	2004	Antidepressants, such as serotonin or noradrenaline reuptake inhibitors (e.g. fluoxetine, nefadozone) or 5-HT1A agonists (flibanserin), desensitize the 5-HT1A autoreceptor, which may contribute to their clinical efficacy.	Norepinephrine	38-51	5-hydroxytryptamine receptor 1A	Homo sapiens	152-158
15599324-4	2004	The univariate analysis demonstrated that CCL2/MCP-1 release was significantly associated with the surgical team in charge for organ harvesting, the proteins for dilution solution, the type of gradient, the type of enzyme, and the donor noradrenalin treatment.	Norepinephrine	237-249	C-C motif chemokine ligand 2	Homo sapiens	42-46
15599324-4	2004	The univariate analysis demonstrated that CCL2/MCP-1 release was significantly associated with the surgical team in charge for organ harvesting, the proteins for dilution solution, the type of gradient, the type of enzyme, and the donor noradrenalin treatment.	Norepinephrine	237-249	C-C motif chemokine ligand 2	Homo sapiens	47-52
15313455-4	2004	Sympathetic nerve endings release noradrenaline (NA) in the proximity of brown fat cells, where noradrenaline activates G-protein-coupled beta-adrenergic receptors (AR) and by doing so initiates a cascade of metabolic events culminating in the activation of uncoupling protein 1 (UCP1).	Norepinephrine	34-47	uncoupling protein 1	Homo sapiens	258-278
15313455-4	2004	Sympathetic nerve endings release noradrenaline (NA) in the proximity of brown fat cells, where noradrenaline activates G-protein-coupled beta-adrenergic receptors (AR) and by doing so initiates a cascade of metabolic events culminating in the activation of uncoupling protein 1 (UCP1).	Norepinephrine	34-47	uncoupling protein 1	Homo sapiens	280-284
15313455-4	2004	Sympathetic nerve endings release noradrenaline (NA) in the proximity of brown fat cells, where noradrenaline activates G-protein-coupled beta-adrenergic receptors (AR) and by doing so initiates a cascade of metabolic events culminating in the activation of uncoupling protein 1 (UCP1).	Norepinephrine	96-109	uncoupling protein 1	Homo sapiens	258-278
15313455-4	2004	Sympathetic nerve endings release noradrenaline (NA) in the proximity of brown fat cells, where noradrenaline activates G-protein-coupled beta-adrenergic receptors (AR) and by doing so initiates a cascade of metabolic events culminating in the activation of uncoupling protein 1 (UCP1).	Norepinephrine	96-109	uncoupling protein 1	Homo sapiens	280-284
15293052-11	2004	We conclude that the effect of training on the response of noradrenaline to exercise seems to be involved in the delay in the normalization of leptin levels.	Norepinephrine	59-72	leptin	Homo sapiens	143-149
15293052-12	2004	We suggest that the amplitude of the noradrenaline response to exercise induced an increase in fat use and a rapid leptin recovery after exercise.	Norepinephrine	37-50	leptin	Homo sapiens	115-121
15276785-1	2004	Previous work using the retrogradely transported immunotoxin, saporin (SAP) conjugated to a monoclonal antibody against dopamine-beta-hydroxylase (DBH; DSAP), to selectively lesion norepinephrine (NE) and epinephrine (E) neurons projecting to the medial hypothalamus, demonstrated the essential role of these neurons for appetitive ingestive responses to glucoprivation.	Norepinephrine	181-195	dopamine beta-hydroxylase	Rattus norvegicus	120-145
15276785-1	2004	Previous work using the retrogradely transported immunotoxin, saporin (SAP) conjugated to a monoclonal antibody against dopamine-beta-hydroxylase (DBH; DSAP), to selectively lesion norepinephrine (NE) and epinephrine (E) neurons projecting to the medial hypothalamus, demonstrated the essential role of these neurons for appetitive ingestive responses to glucoprivation.	Norepinephrine	181-195	dopamine beta-hydroxylase	Rattus norvegicus	147-150
15495941-1	2004	The DBH gene encodes dopamine-beta-hydroxylase (DbetaH), the enzyme that catalyses the formation of norepinephrine from dopamine.	Norepinephrine	100-114	dopamine beta-hydroxylase	Homo sapiens	4-7
15495941-1	2004	The DBH gene encodes dopamine-beta-hydroxylase (DbetaH), the enzyme that catalyses the formation of norepinephrine from dopamine.	Norepinephrine	100-114	dopamine beta-hydroxylase	Homo sapiens	21-46
15495941-1	2004	The DBH gene encodes dopamine-beta-hydroxylase (DbetaH), the enzyme that catalyses the formation of norepinephrine from dopamine.	Norepinephrine	100-114	dopamine beta-hydroxylase	Homo sapiens	48-54
15193150-0	2004	Noradrenaline represses PPAR (peroxisome-proliferator-activated receptor) gamma2 gene expression in brown adipocytes: intracellular signalling and effects on PPARgamma2 and PPARgamma1 protein levels.	Norepinephrine	0-13	peroxisome proliferator activated receptor alpha	Homo sapiens	24-28
15242813-3	2004	We did not identify an inhibition at the level of the adrenergic receptors, but a first site of inhibition was identified as the generation of cAMP by adenylyl cyclase; this led to inhibition of norepinephrine-induced expression of the uncoupling protein-1 (UCP1) gene and reduced norepinephrine-induced lipolysis as secondary effects.	Norepinephrine	195-209	uncoupling protein 1	Homo sapiens	236-262
15363607-0	2004	Noradrenaline storage function of species-specific protein bodies, markers of monoamine neurons in human locus coeruleus demonstrated by dopamine-beta-hydroxylase immunogold localization.	Norepinephrine	0-13	dopamine beta-hydroxylase	Homo sapiens	137-162
15363607-7	2004	Since dopamine-beta-hydroxylase (DBH) is a hallmark of noradrenaline identity and present in dense core vesicles, the investigation of DBH localization with the immunogold method constituted the experiment of choice for this study.	Norepinephrine	55-68	dopamine beta-hydroxylase	Homo sapiens	6-31
15363607-7	2004	Since dopamine-beta-hydroxylase (DBH) is a hallmark of noradrenaline identity and present in dense core vesicles, the investigation of DBH localization with the immunogold method constituted the experiment of choice for this study.	Norepinephrine	55-68	dopamine beta-hydroxylase	Homo sapiens	33-36
15027894-9	2004	Interaction revealed that subjects with high cortisol/low noradrenaline had higher PAI-1 than subjects with low cortisol/high noradrenaline (P=0.038).	Norepinephrine	58-71	serpin family E member 1	Homo sapiens	83-88
15189762-0	2004	Resistin, but not adiponectin, inhibits dopamine and norepinephrine release in the hypothalamus.	Norepinephrine	53-67	resistin	Homo sapiens	0-8
15189762-5	2004	We have found that adiponectin does not modify either basal or depolarization-induced amine release, while resistin inhibits the stimulated release of dopamine and norepinephrine, leaving unaffected serotonin release.	Norepinephrine	164-178	resistin	Homo sapiens	107-115
14722031-5	2004	Total and renal norepinephrine spillover rates correlated directly with whole body leptin secretion rate.	Norepinephrine	16-30	leptin	Homo sapiens	83-89
15030373-13	2004	During ETA blockade, noradrenaline increased after haemorrhage instead of adrenaline, and the MAP recovery after retransfusion was blunted.	Norepinephrine	21-34	endothelin receptor type A	Canis lupus familiaris	7-10
14617573-3	2004	Treatment of pinealocytes with norepinephrine (NE) caused a time-dependent increase in the levels of AA-NAT mRNA, AA-NAT protein, and enzymatic activity as well as MT production.	Norepinephrine	31-45	aralkylamine N-acetyltransferase	Rattus norvegicus	101-107
14617573-3	2004	Treatment of pinealocytes with norepinephrine (NE) caused a time-dependent increase in the levels of AA-NAT mRNA, AA-NAT protein, and enzymatic activity as well as MT production.	Norepinephrine	31-45	aralkylamine N-acetyltransferase	Rattus norvegicus	114-120
14715701-5	2004	Epinephrine and norepinephrine up-regulated MMP-1 and potentiated LPS-induced expression of MMP-1 in peripheral blood monocytes and monocyte-derived macrophages.	Norepinephrine	16-30	matrix metallopeptidase 1	Homo sapiens	44-49
14715701-5	2004	Epinephrine and norepinephrine up-regulated MMP-1 and potentiated LPS-induced expression of MMP-1 in peripheral blood monocytes and monocyte-derived macrophages.	Norepinephrine	16-30	matrix metallopeptidase 1	Homo sapiens	92-97
14757141-6	2004	These results indicate that a large part of basal release of noradrenaline in the basolateral nucleus of the amygdala is under tonic inhibitory control by endogenous nociceptin/orphanin FQ through the N/OFQ peptide receptors localized within the basolateral nucleus of the amygdala.	Norepinephrine	61-74	prepronociceptin	Rattus norvegicus	177-188
14729385-2	2004	An extensive body of evidence shows that activation of the histamine H3 receptor attenuates sympathetic tone by presynaptic inhibition of noradrenaline release.	Norepinephrine	138-151	histamine receptor H3	Homo sapiens	59-80
14732207-0	2004	Norepinephrine-induced acute heart failure in transgenic mice overexpressing erythropoietin.	Norepinephrine	0-14	erythropoietin	Mus musculus	77-91
14508509-3	2003	Since monoamine oxidase A metabolises noradrenalin, a positive association with the MAOA gene would be biologically plausible.	Norepinephrine	38-50	monoamine oxidase A	Homo sapiens	6-25
14508509-3	2003	Since monoamine oxidase A metabolises noradrenalin, a positive association with the MAOA gene would be biologically plausible.	Norepinephrine	38-50	monoamine oxidase A	Homo sapiens	84-88
14598308-0	2003	Centrally administered norepinephrine modifies the behavior induced by corticotropin-releasing factor in neonatal chicks.	Norepinephrine	23-37	corticotropin releasing hormone	Homo sapiens	71-101
14598308-1	2003	We previously reported that glucagon-like peptide-1 decreased corticotropin-releasing factor (CRF)-induced behaviors in neonatal chicks, and such an effect is hypothesized to act through norepinephrine (NE).	Norepinephrine	187-201	corticotropin releasing hormone	Homo sapiens	62-92
12967948-11	2003	(6) These data suggested (1) a role for the 5-lipoxygenase pathway in the regulation of blood pressure in l-NAME-treated rats and (2) the involvement of endothelial CysLTs in noradrenaline-induced contraction in aorta from l-NAME-treated rats.	Norepinephrine	175-188	arachidonate 5-lipoxygenase	Rattus norvegicus	44-58
12871653-2	2003	The memory enhancing action of noradrenaline injected into the basal ganglia (lobus parolfactorius-LPO) was reduced in the presence of the alpha(2)-adrenoceptor antagonist yohimbine, but when noradrenaline was injected into the multi-modal association area (intermediate medial hyperstriatum ventrale-IMHV), yohimbine failed to prevent memory enhancement.	Norepinephrine	31-44	lactoperoxidase	Gallus gallus	99-102
12871653-2	2003	The memory enhancing action of noradrenaline injected into the basal ganglia (lobus parolfactorius-LPO) was reduced in the presence of the alpha(2)-adrenoceptor antagonist yohimbine, but when noradrenaline was injected into the multi-modal association area (intermediate medial hyperstriatum ventrale-IMHV), yohimbine failed to prevent memory enhancement.	Norepinephrine	192-205	lactoperoxidase	Gallus gallus	99-102
12810089-1	2003	We had previously reported that activation of histamine H(3)-receptors (H(3)R) on cardiac adrenergic nerve terminals decreases norepinephrine (NE) overflow from ischemic hearts and alleviates reperfusion arrhythmias.	Norepinephrine	127-141	histamine receptor H3	Mus musculus	72-77
12774312-1	2003	Previously we reported that the synthesis of catecholamines, dopamine, and noradrenaline was enhanced by overexpression of V-1 protein, a neuronal protein active in the initial stage of development of the rat cerebellum, in the neuronal cell line PC12D, a model of dopamine cells (Yamakuni et al.	Norepinephrine	75-88	myotrophin	Rattus norvegicus	123-134
12802890-4	2003	Correlations among dopamine-beta-hydroxylase measures and behavior reinforced these tonic norepinephrine/behavior associations.	Norepinephrine	90-104	dopamine beta-hydroxylase	Rattus norvegicus	19-44
12609984-4	2003	We used sympathetic neurons and SK-N-BE(2)M17 neuroblastoma cells to investigate CDF down-regulation of the norepinephrine synthetic enzyme dopamine-beta-hydroxylase (DBH).	Norepinephrine	108-122	dopamine beta-hydroxylase	Homo sapiens	140-165
12609984-4	2003	We used sympathetic neurons and SK-N-BE(2)M17 neuroblastoma cells to investigate CDF down-regulation of the norepinephrine synthetic enzyme dopamine-beta-hydroxylase (DBH).	Norepinephrine	108-122	dopamine beta-hydroxylase	Homo sapiens	167-170
12641739-1	2003	The rat pineal gland is a suitable model to investigate neurotransmitter-controlled gene expression, because it is well established that the stimulation of melatonin biosynthesis by norepinephrine (NE) depends on the activation of the gene that encodes arylalkylamine N-acetyltransferase (AANAT), the melatonin rhythm enzyme.	Norepinephrine	182-196	aralkylamine N-acetyltransferase	Rattus norvegicus	253-287
12641739-1	2003	The rat pineal gland is a suitable model to investigate neurotransmitter-controlled gene expression, because it is well established that the stimulation of melatonin biosynthesis by norepinephrine (NE) depends on the activation of the gene that encodes arylalkylamine N-acetyltransferase (AANAT), the melatonin rhythm enzyme.	Norepinephrine	182-196	aralkylamine N-acetyltransferase	Rattus norvegicus	289-294
15166499-0	2003	Norepinephrine upregulates vascular endothelial growth factor in rat cardiac myocytes by a paracrine mechanism.	Norepinephrine	0-14	vascular endothelial growth factor A	Rattus norvegicus	27-61
15166499-2	2003	The present study in cultured neonatal rat cardiac myocytes tested the hypothesis that norepinephrine also stimulates expression of vascular endothelial growth factor (VEGF), an important angiogenic factor.	Norepinephrine	87-101	vascular endothelial growth factor A	Rattus norvegicus	132-166
15166499-2	2003	The present study in cultured neonatal rat cardiac myocytes tested the hypothesis that norepinephrine also stimulates expression of vascular endothelial growth factor (VEGF), an important angiogenic factor.	Norepinephrine	87-101	vascular endothelial growth factor A	Rattus norvegicus	168-172
15166499-4	2003	When cardiac myocytes were stimulated with 1 micro M norepinephrine for 24 h in the presence or absence of the specific alpha - and beta -adrenoceptor antagonists prazosin and propranolol, respectively, VEGF mRNA levels and splice variant pattern did not change, whereas atrial natriuretic peptide mRNA levels increased 3 to 4-fold.	Norepinephrine	53-67	vascular endothelial growth factor A	Rattus norvegicus	203-207
15166499-6	2003	When cardiac myocytes were cultured with conditioned medium from non-myocytes that had been stimulated with norepinephrine for 24 h VEGF mRNA increased 2-fold.	Norepinephrine	108-122	vascular endothelial growth factor A	Rattus norvegicus	132-136
12488060-2	2002	Dopamine-beta-hydroxylase (DbetaH) converts dopamine to norepinephrine.	Norepinephrine	56-70	dopamine beta-hydroxylase	Homo sapiens	0-25
12488060-2	2002	Dopamine-beta-hydroxylase (DbetaH) converts dopamine to norepinephrine.	Norepinephrine	56-70	dopamine beta-hydroxylase	Homo sapiens	27-33
12457232-1	2002	The rat pineal organ is an established model to study signal transduction cascades that are activated by norepinephrine (NE) and cause increases in cAMP levels and stimulation of protein kinase A (PKA).	Norepinephrine	105-119	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	197-200
12882365-8	2002	The most prominent neurochemical alterations in the forebrains of aged eNOS-/- mice were: (a) increased acetylcholine levels in the neostriatum; (b) decreased noradrenaline concentrations in the ventral striatum; and (c) lower serotonin levels in the frontal cortex and ventral striatum.	Norepinephrine	159-172	nitric oxide synthase 3, endothelial cell	Mus musculus	71-75
12423672-8	2002	An alpha2 agonist clonidine and dobutamine upregulated the expression of mRNA encoding catechol-O-methyl transferase, an important enzyme to degrade norepinephrine.	Norepinephrine	149-163	catechol-O-methyltransferase	Rattus norvegicus	87-116
12475182-3	2002	Testosterone-treated cells showed fewer and smaller lipid droplets than control cells and a dose-dependent inhibition of UCP1 mRNA expression, under adrenergic stimulation by norepinephrine (NE).	Norepinephrine	175-189	uncoupling protein 1	Homo sapiens	121-125
12241539-0	2002	The Trp64Arg beta3-adrenergic receptor amino acid variant confers increased sensitivity to the pressor effects of noradrenaline in Sardinian subjects.	Norepinephrine	114-127	adrenoceptor beta 3	Homo sapiens	13-38
12241539-3	2002	The aim of the present study was to evaluate the effect of the Trp64Arg beta(3)AR variant on the regulation of triacylglycerol levels and blood pressure during the exogenous infusion of noradrenaline.	Norepinephrine	186-199	adrenoceptor beta 3	Homo sapiens	72-81
12241539-11	2002	In conclusion, our data indicate that the Trp64Arg amino acid variant of the beta(3)AR confers increased sensitivity to the pressure effect of noradrenaline.	Norepinephrine	143-156	adrenoceptor beta 3	Homo sapiens	77-86
12202245-3	2002	Alpha(2B)-AR bind natural (adrenaline and noradrenaline) and synthetic ligands with different affinities to mediate a variety of physiological and pharmacological responses.	Norepinephrine	42-55	adrenoceptor alpha 2B	Homo sapiens	0-12
12176394-5	2002	When rat tail artery was treated with norepinephrine (10 mM), PLCbeta2 was shown to translocate from cytosol to membranes.	Norepinephrine	38-52	phospholipase C, beta 2	Rattus norvegicus	62-70
12176394-8	2002	This evidence is consistent with the model wherein an agonist such as norepinephrine can activate smooth muscle contraction via interaction with a plasma membrane receptor which can easily interact with a plasma membrane-associated isoform of PLC, such as PLCbeta2.	Norepinephrine	70-84	phospholipase C, beta 2	Rattus norvegicus	256-264
12091475-1	2002	The antidepressant desipramine (DMI) is a selective inhibitor of norepinephrine (NE) transport that down-regulates the norepinephrine transporter (NET) protein in a concentration- and time-dependent manner in vitro.	Norepinephrine	65-79	solute carrier family 6 member 2	Rattus norvegicus	119-145
12091475-1	2002	The antidepressant desipramine (DMI) is a selective inhibitor of norepinephrine (NE) transport that down-regulates the norepinephrine transporter (NET) protein in a concentration- and time-dependent manner in vitro.	Norepinephrine	65-79	solute carrier family 6 member 2	Rattus norvegicus	147-150
12056558-5	2002	Substance P and NK1 receptors are also intimately associated with ascending 5-HT and norepinephrine projections to the forebrain, and alterations in the function of these systems are also likely to be related to the antidepressant efficacy of SPAs.	Norepinephrine	85-99	tachykinin 1	Mus musculus	0-11
12056558-5	2002	Substance P and NK1 receptors are also intimately associated with ascending 5-HT and norepinephrine projections to the forebrain, and alterations in the function of these systems are also likely to be related to the antidepressant efficacy of SPAs.	Norepinephrine	85-99	tachykinin 1	Mus musculus	16-19
11956964-5	2002	The homozygous Ala280Val variation in the third intracellular loop of the histamine H(3) receptor of a patient with Shy-Drager syndrome may be related to the etiology of the illness due to altered norepinephrine release.	Norepinephrine	197-211	histamine receptor H3	Homo sapiens	74-97
11919656-4	2002	The ratios of V(max) for noradrenaline uptake and B(max) for nisoxetine binding (which are a measure of the turnover number of the transporter, i.e. the number of transport cycles per min) were greater for rNET and rR612Q than for hNET, rK7D, rE62K and rK375N.	Norepinephrine	25-38	solute carrier family 6 member 2	Rattus norvegicus	206-210
11919656-5	2002	The K(m) of noradrenaline was lower for hNET, rK7D, rE62K and rK375N than for rNET or rR612Q.	Norepinephrine	12-25	solute carrier family 6 member 2	Rattus norvegicus	78-82
12077484-3	2002	Norepinephrine (NE) induced AA-NAT and Per1, whereas its effect on Per2 was negligible.	Norepinephrine	0-14	aralkylamine N-acetyltransferase	Rattus norvegicus	28-34
11805341-1	2002	Noradrenaline (NA), a key neurotransmitter of the endogenous pain inhibitory system, acutely inhibits nociceptive transmission (including that mediated by substance P), potentiates opioid analgesia, and underlies part of the antinociceptive effects of the widely prescribed tricyclic antidepressants.	Norepinephrine	0-13	tachykinin 1	Mus musculus	155-166
11752397-0	2002	Decreased intracellular calcium mediates the histamine H3-receptor-induced attenuation of norepinephrine exocytosis from cardiac sympathetic nerve endings.	Norepinephrine	90-104	histamine receptor H3	Homo sapiens	45-66
11752397-1	2002	Activation of presynatic histamine H(3) receptors (H(3)R) down-regulates norepinephrine exocytosis from cardiac sympathetic nerve terminals, in both normal and ischemic conditions.	Norepinephrine	73-87	histamine receptor H3	Homo sapiens	14-57
12140786-1	2002	Monoamine oxidase A (MAO A) is located on the X chromosome and metabolizes biogenic amines including dopamine, norepinephrine and serotonin.	Norepinephrine	111-125	monoamine oxidase A	Homo sapiens	0-19
12140786-1	2002	Monoamine oxidase A (MAO A) is located on the X chromosome and metabolizes biogenic amines including dopamine, norepinephrine and serotonin.	Norepinephrine	111-125	monoamine oxidase A	Homo sapiens	21-26
11823070-8	2002	The mechanism by which chronic substance P receptor antagonist or conventional antidepressant treatment influences the pattern of firing activity of norepinephrine neurones remains to be elucidated.	Norepinephrine	149-163	tachykinin receptor 1	Homo sapiens	31-51
11551920-2	2001	The alpha(1)-adrenergic agonist, norepinephrine (NE), enhances epidermal growth factor-stimulated DNA synthesis and inhibits activin A-induced growth inhibition, but the mechanisms of these actions are unclear.	Norepinephrine	33-47	inhibin subunit beta A	Rattus norvegicus	125-134
11729636-4	2001	BAT thermogenesis by UCP-1, which has been studied most extensively, is controlled directly by sympathetic nerves principally through the beta-adrenergic action of norepinephrine.	Norepinephrine	164-178	uncoupling protein 1	Homo sapiens	21-26
11514309-1	2001	Phenylethanolamine N-methyltransferase (PNMT) is the enzyme that synthesizes epinephrine from norepinephrine.	Norepinephrine	94-108	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-38
11514309-1	2001	Phenylethanolamine N-methyltransferase (PNMT) is the enzyme that synthesizes epinephrine from norepinephrine.	Norepinephrine	94-108	phenylethanolamine-N-methyltransferase	Rattus norvegicus	40-44
11532892-3	2001	Noradrenaline dose-dependently stimulates phosphoinositide (PI) breakdown in both immature and mature cultures through the activation of alpha1 receptors.	Norepinephrine	0-13	adrenoceptor alpha 1D	Homo sapiens	137-143
11798029-8	2001	Nucleotides maintain the proton conductance inhibited while fatty acids act as cytosolic second messengers of noradrenaline to active UCP1.	Norepinephrine	110-123	uncoupling protein 1	Homo sapiens	134-138
11504801-0	2001	Alpha(1) and beta(2) adrenoreceptor agonists inhibit pentylenetetrazole-induced seizures in mice lacking norepinephrine.	Norepinephrine	105-119	adrenergic receptor, beta 2	Mus musculus	13-35
11337745-2	2001	Since previous findings showed that some families with autistic children have a low level of serum dopamine beta-hydroxylase (DbetaH), which catalyzes the conversion of dopamine to norepinephrine, we examined the DBH gene as a candidate locus in families with two or more children with autism spectrum disorder using the affected sib-pair method.	Norepinephrine	181-195	dopamine beta-hydroxylase	Homo sapiens	99-124
11306460-6	2001	In summary, norepinephrine-induced locomotion of SW 480 cells is beta2-adrenoceptor mediated and distinct from spontaneous locomotion concerning the PTK involvement.	Norepinephrine	12-26	protein tyrosine kinase 2 beta	Homo sapiens	149-152
11282402-1	2001	Dopamine beta-hydroxylase (DBH) catalyzes the beta-hydroxylation of dopamine to norepinephrine.	Norepinephrine	80-94	dopamine beta-hydroxylase	Homo sapiens	0-25
11282402-1	2001	Dopamine beta-hydroxylase (DBH) catalyzes the beta-hydroxylation of dopamine to norepinephrine.	Norepinephrine	80-94	dopamine beta-hydroxylase	Homo sapiens	27-30
11310603-2	2001	Metaraminol ((1R,2S)-2-amino-1-(3-hydroxyphenyl)-1-propanol) is a metabolically stable structural analogue of norepinephrine and possesses high affinity towards the norepinephrine transporter and the vesicular monoamine transporter.	Norepinephrine	110-124	solute carrier family 6 member 2	Rattus norvegicus	165-191
11160591-5	2001	Anemia (by causing hypoxia) and iron deficiency (by increasing serum norepinephrine concentrations) can induce maternal and fetal stress, which stimulates the synthesis of corticotropin-releasing hormone (CRH).	Norepinephrine	69-83	corticotropin releasing hormone	Homo sapiens	172-203
11160591-5	2001	Anemia (by causing hypoxia) and iron deficiency (by increasing serum norepinephrine concentrations) can induce maternal and fetal stress, which stimulates the synthesis of corticotropin-releasing hormone (CRH).	Norepinephrine	69-83	corticotropin releasing hormone	Homo sapiens	205-208
11516836-10	2001	These results indicate that arylalkylamine N-acetyltransferase mRNA in ganglionectomized rats is not induced by circulating catecholamines and may be caused by both a centrally originated norepinephrine, as already suggested, and other non-adrenergic transmitter(s).	Norepinephrine	188-202	aralkylamine N-acetyltransferase	Rattus norvegicus	28-62
11516836-11	2001	In conclusion, this work shows that norepinephrine drives the nocturnal increase of arylalkylamine N-acetyltransferase gene expression both in the superficial and deep pineal and strongly suggests that other neurotransmitters are involved in day-time inhibition and night-time stimulation of pineal metabolism.	Norepinephrine	36-50	aralkylamine N-acetyltransferase	Rattus norvegicus	84-118
11120594-2	2000	In the present study, we show that norepinephrine and terbutaline stimulate the beta2AR to decrease the level of IL-2 produced by freshly isolated murine splenic naive CD4+ T cells from either Balb/C or DO11.10 transgenic mice and activated polyclonally with anti-CD3 and anti-CD28 mAbs.	Norepinephrine	35-49	adrenergic receptor, beta 2	Mus musculus	80-87
11120594-2	2000	In the present study, we show that norepinephrine and terbutaline stimulate the beta2AR to decrease the level of IL-2 produced by freshly isolated murine splenic naive CD4+ T cells from either Balb/C or DO11.10 transgenic mice and activated polyclonally with anti-CD3 and anti-CD28 mAbs.	Norepinephrine	35-49	interleukin 2	Mus musculus	113-117
11100982-2	2000	We previously demonstrated that atrial natriuretic factor and B- and C-type natriuretic peptides (ANF, BNP, and CNP, respectively) modified catecholamine metabolism by increasing the neuronal uptake and decreasing the neuronal release of norepinephrine in the rat hypothalamus.	Norepinephrine	238-252	2',3'-cyclic nucleotide 3' phosphodiesterase	Rattus norvegicus	112-115
11100982-3	2000	The aim of the present work was to study the effects of natriuretic peptides BNP and CNP on norepinephrine uptake as an index of the amine metabolism in discrete areas and nuclei of the central nervous system (CNS) of the rat.	Norepinephrine	92-106	2',3'-cyclic nucleotide 3' phosphodiesterase	Rattus norvegicus	85-88
11100982-6	2000	Results showed that 100 nM BNP and 1 nM CNP increased norepinephrine (NE) uptake in all brain areas and nuclei studied.	Norepinephrine	54-68	2',3'-cyclic nucleotide 3' phosphodiesterase	Rattus norvegicus	40-43
11084220-4	2000	The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA.	Norepinephrine	22-35	interleukin 1 receptor antagonist	Homo sapiens	175-181
11084220-4	2000	The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA.	Norepinephrine	22-35	interleukin 1 receptor antagonist	Homo sapiens	351-357
11084220-4	2000	The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA.	Norepinephrine	96-109	interleukin 1 receptor antagonist	Homo sapiens	175-181
11084220-4	2000	The results show that noradrenaline, 10(-5) M, significantly suppressed the production of IL-6; noradrenaline, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA and TNF alpha; clonidine, 10(-5) M, significantly suppressed the production of TNF alpha; and yohimbine, 10(-5) and 10(-6) M, significantly suppressed the production of IL-1RA.	Norepinephrine	96-109	interleukin 1 receptor antagonist	Homo sapiens	351-357
11055982-5	2000	In mouse myocyte cultures, triiodothyronine (T3), norepinephrine (NE) through a beta-adrenergic receptor, and leukemia inhibitory factor induced hypertrophy by a 20% to 30% increase in [(3)H]phenylalanine-labeled protein content.	Norepinephrine	50-64	leukemia inhibitory factor	Mus musculus	80-136
11003990-4	2000	When PBMC were stimulated with 10(-8)M norepinephrine in vitro, the expression of these adhesion molecules on CD3(-)CD56(+) NK cells was downmodulated within 30 min.	Norepinephrine	39-53	neural cell adhesion molecule 1	Homo sapiens	116-120
10998646-10	2000	Co-incubation of P. aeruginosa with norepinephrine increased PA-I expression in vitro, suggesting that norepinephrine plays a role in the observed response in vivo.	Norepinephrine	36-50	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	61-65
10998646-10	2000	Co-incubation of P. aeruginosa with norepinephrine increased PA-I expression in vitro, suggesting that norepinephrine plays a role in the observed response in vivo.	Norepinephrine	103-117	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	61-65
10991930-5	2000	Nociceptin produced a concentration-dependent inhibition of the adrenergic motor response to electrical-field stimulation (EC(50) 19 nM, pEC(50) 7.7+/-0.1, n=8), but the response to exogenous noradrenaline (0.2 - 1 microM) was unaffected.	Norepinephrine	192-205	prepronociceptin	Rattus norvegicus	0-10
10971815-13	2000	infusion of E2, which induces a preovulatory surge-like release of LH, stimulates brain noradrenaline activity; this enhanced activity likely involves an ER-mediated process and is reflected by hypothalamic noradrenaline release and locus coeruleus TH mRNA expression.	Norepinephrine	88-101	tyrosine hydroxylase	Macaca mulatta	249-251
10900181-0	2000	Interactions of dynorphin A-(1-13) and nociceptin with cardiac D2 binding sites: inhibition of ischemia-evoked release of noradrenaline from synaptosomal-mitochondrial fractions.	Norepinephrine	122-135	prepronociceptin	Rattus norvegicus	39-49
10878345-1	2000	The neurotransmitter norepinephrine (NE) binds to the beta 2-adrenergic receptor (beta 2AR) expressed on various immune cells to influence cell homing, proliferation, and function.	Norepinephrine	21-35	adrenergic receptor, beta 2	Mus musculus	54-80
10878345-1	2000	The neurotransmitter norepinephrine (NE) binds to the beta 2-adrenergic receptor (beta 2AR) expressed on various immune cells to influence cell homing, proliferation, and function.	Norepinephrine	21-35	adrenergic receptor, beta 2	Mus musculus	82-90
10997600-2	2000	Both serotonin, acting through 5HT1B/2C receptors, and norepinephrine acting through beta2 and/or beta3 receptors reduce food intake and augment sympathetic activity.	Norepinephrine	55-69	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	98-103
10997617-5	2000	Activity and expression of the three UCP"s are stimulated by several neuromediators and hormones such as noradrenaline, tri-iodothyronine and leptin.	Norepinephrine	105-118	uncoupling protein 1	Homo sapiens	37-40
10835639-0	2000	Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system.	Norepinephrine	47-60	GATA binding protein 3	Mus musculus	0-5
10788502-0	2000	Norepinephrine induces vascular endothelial growth factor gene expression in brown adipocytes through a beta -adrenoreceptor/cAMP/protein kinase A pathway involving Src but independently of Erk1/2.	Norepinephrine	0-14	Rous sarcoma oncogene	Mus musculus	165-168
10769386-1	2000	The action of norepinephrine (NE) is terminated, in part, by its uptake into presynaptic noradrenergic neurons by the plasma-membrane NE transporter (NET), which is a target for antidepressants and psychostimulants.	Norepinephrine	14-28	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Mus musculus	134-148
10769386-1	2000	The action of norepinephrine (NE) is terminated, in part, by its uptake into presynaptic noradrenergic neurons by the plasma-membrane NE transporter (NET), which is a target for antidepressants and psychostimulants.	Norepinephrine	14-28	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Mus musculus	150-153
10718926-10	2000	In summary, these experiments suggest that adrenoceptors and not dopamine receptors are responsible for the inhibitory effect of noradrenaline on prolactin secretion in vitro but do not implicate a particular adrenoceptor subtype.	Norepinephrine	129-142	prolactin	Ovis aries	146-155
10715359-2	2000	In turn, neuropeptide Y (NPY) has been shown to inhibit the release of norepinephrine from sympathetic noradrenergic neurons.	Norepinephrine	71-85	neuropeptide Y	Homo sapiens	9-23
10715359-2	2000	In turn, neuropeptide Y (NPY) has been shown to inhibit the release of norepinephrine from sympathetic noradrenergic neurons.	Norepinephrine	71-85	neuropeptide Y	Homo sapiens	25-28
10762326-2	2000	This rhythm involves the transcriptional regulation of the AANAT by two norepinephrine (NE)-inducible transcription factors, e.g. the activator pCREB (phosphorylated Ca2+/cAMP-response element binding protein) and the inhibitor ICER (inducible cAMP early repressor).	Norepinephrine	72-86	arylalkylamine N-acetyltransferase	Mus musculus	59-64
10723850-12	2000	Disulfiram inhibits dopamine beta-hydroxylase resulting in an excess of dopamine and decreased synthesis of norepinephrine.	Norepinephrine	108-122	dopamine beta-hydroxylase	Homo sapiens	20-45
23531135-6	2000	Inhibitors of MAO A are clinically useful to treat anxiety and depression since they are expected to increase both noradrenalin and serotonin levels in the brain.	Norepinephrine	115-127	monoamine oxidase A	Homo sapiens	14-19
10629750-2	1999	Upon binding of L-glutamate to the class II metabotropic glutamate receptor, norepinephrine (NE)-dependent formation of cAMP was inhibited, resulting in decreased serotonin-N-acetyltransferase (NAT) activity and melatonin output.	Norepinephrine	77-91	aralkylamine N-acetyltransferase	Rattus norvegicus	163-192
10629750-2	1999	Upon binding of L-glutamate to the class II metabotropic glutamate receptor, norepinephrine (NE)-dependent formation of cAMP was inhibited, resulting in decreased serotonin-N-acetyltransferase (NAT) activity and melatonin output.	Norepinephrine	77-91	aralkylamine N-acetyltransferase	Rattus norvegicus	194-197
10619567-10	1999	These results show that homozygous BDNF mutations produce severe depletions within the nigrostriatal dopaminergic system and substantial reductions of norepinephrine within the hypothalamus and olfactory bulb.	Norepinephrine	151-165	brain derived neurotrophic factor	Mus musculus	35-39
10573542-1	1999	Dopamine beta-monooxygenase (DBM), a cuproenzyme, converts dopamine to norepinephrine in selected cells.	Norepinephrine	71-85	dopamine beta-hydroxylase	Rattus norvegicus	0-27
10573542-1	1999	Dopamine beta-monooxygenase (DBM), a cuproenzyme, converts dopamine to norepinephrine in selected cells.	Norepinephrine	71-85	dopamine beta-hydroxylase	Rattus norvegicus	29-32
10560019-0	1999	Genetic approaches to studying norepinephrine function: knockout of the mouse norepinephrine transporter gene.	Norepinephrine	31-45	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Mus musculus	78-104
10560019-6	1999	For the norepinephrine transporter knockout mice, this altered state of the norepinephrine system should simulate the therapeutic effects of norepinephrine selective antidepressants and some of the effects of psychostimulants.	Norepinephrine	76-90	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Mus musculus	8-34
10535767-1	1999	Phosphorylation of cyclic AMP response element binding protein (CREB) at amino acid serine 133 appears as an important link between the norepinephrine (NE)-induced activation of second messenger systems and the stimulation of melatonin biosynthesis.	Norepinephrine	136-150	cAMP responsive element binding protein 1	Rattus norvegicus	19-62
10535767-1	1999	Phosphorylation of cyclic AMP response element binding protein (CREB) at amino acid serine 133 appears as an important link between the norepinephrine (NE)-induced activation of second messenger systems and the stimulation of melatonin biosynthesis.	Norepinephrine	136-150	cAMP responsive element binding protein 1	Rattus norvegicus	64-68
10385422-0	1999	Fluctuating estrogen and progesterone receptor expression in brainstem norepinephrine neurons through the rat estrous cycle.	Norepinephrine	71-85	progesterone receptor	Rattus norvegicus	25-46
10375675-1	1999	In the rat pineal gland, norepinephrine activates alpha1- and beta-adrenergic receptors and triggers melatonin production through an increase in the intracellular calcium concentration ([Ca2+]i) and stimulation of the cAMP/cAMP responsive element-binding protein (CREB) cascade.	Norepinephrine	25-39	cAMP responsive element binding protein 1	Rattus norvegicus	218-262
10375675-1	1999	In the rat pineal gland, norepinephrine activates alpha1- and beta-adrenergic receptors and triggers melatonin production through an increase in the intracellular calcium concentration ([Ca2+]i) and stimulation of the cAMP/cAMP responsive element-binding protein (CREB) cascade.	Norepinephrine	25-39	cAMP responsive element binding protein 1	Rattus norvegicus	264-268
10375675-5	1999	Norepinephrine-regulated calcium signaling and phosphorylation of CREB are already fully developed at birth, i.e., prior to ingrowth of the sympathetic innervation into the pineal parenchyma, and appear to develop in an innervation-independent manner.	Norepinephrine	0-14	cAMP responsive element binding protein 1	Rattus norvegicus	66-70
10375680-2	1999	LHRH secretion is probably controlled by prior pulsatile norepinephrine (NE) release.	Norepinephrine	57-71	gonadotropin releasing hormone 1	Rattus norvegicus	0-4
9933594-8	1999	Inhibition of Cdk5 with olomoucine decreased evoked norepinephrine secretion from chromaffin cells, an effect not observed with the inactive analogue iso-olomoucine.	Norepinephrine	52-66	cyclin dependent kinase 5	Homo sapiens	14-18
9930750-2	1999	A quantitative double-label in situ hybridization technique was used to examine CNS GTPCH mRNA expression within serotonin, dopamine, and norepinephrine neurons of male and female wild-type and hph-1 mice.	Norepinephrine	138-152	GTP cyclohydrolase 1	Mus musculus	84-89
9878889-0	1999	Accumulation of 3,4-dihydroxyphenylglycolaldehyde, the neurotoxic monoamine oxidase A metabolite of norepinephrine, in locus ceruleus cell bodies in Alzheimer"s disease: mechanism of neuron death.	Norepinephrine	100-114	monoamine oxidase A	Homo sapiens	66-85
9878889-1	1999	3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the neurotoxic monoamine oxidase A (MAO-A) metabolite of norepinephrine (NE).	Norepinephrine	104-118	monoamine oxidase A	Homo sapiens	62-81
9878889-1	1999	3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the neurotoxic monoamine oxidase A (MAO-A) metabolite of norepinephrine (NE).	Norepinephrine	104-118	monoamine oxidase A	Homo sapiens	83-88
10094138-1	1999	The effect of the cholinesterase inhibitor neostigmine on hippocampal noradrenaline (NA) release was studied using in vivo microdialysis.	Norepinephrine	70-83	butyrylcholinesterase	Homo sapiens	18-32
9917358-0	1999	The neurotransmitter noradrenaline drives noggin-expressing ectoderm cells to activate N-tubulin and become neurons.	Norepinephrine	21-34	tubulin beta 2B class IIb S homeolog	Xenopus laevis	87-96
9917358-6	1999	By contrast, 10(-8) M noradrenaline activated N-tubulin in ectoderm caps expressing the neural inducing molecule noggin by the time intact siblings had become mid-neurulae.	Norepinephrine	22-35	tubulin beta 2B class IIb S homeolog	Xenopus laevis	46-55
9917358-8	1999	The alpha-adrenergic receptor blocker prazosin inhibited both noradrenaline- and methoxamine-induced activation of N-tubulin.	Norepinephrine	62-75	tubulin beta 2B class IIb S homeolog	Xenopus laevis	115-124
9917358-13	1999	We propose that noradrenaline is an important endogenous modulator of neuronal fate, driving noggin-expressing cells to become neurons by binding to alpha-adrenergic receptors and activating a cascade that culminates in the expression of the neuronal markers N-tubulin and 3A10.	Norepinephrine	16-29	tubulin beta 2B class IIb S homeolog	Xenopus laevis	259-268
10075201-3	1999	The primary antibody used recognized DBH, the key enzyme in the conversion of dopamine to noradrenaline.	Norepinephrine	90-103	dopamine beta-hydroxylase	Homo sapiens	37-40
10075201-9	1999	CONCLUSIONS: The localization of DBH-related immunoreactivity is generally consistent with the known physiological roles of noradrenaline.	Norepinephrine	124-137	dopamine beta-hydroxylase	Homo sapiens	33-36
10027098-0	1999	Histamine H3 receptor-mediated inhibition of noradrenaline release in the human brain.	Norepinephrine	45-58	histamine receptor H3	Homo sapiens	0-21
10465445-5	1999	Local infusion of the acetylcholinesterase inhibitor soman (0.4 mM) into the olfactory bulb increased basal norepinephrine levels by 134% of control, suggesting that endogenously released acetylcholine modulates norepinephrine release.	Norepinephrine	108-122	acetylcholinesterase	Rattus norvegicus	22-42
10465445-5	1999	Local infusion of the acetylcholinesterase inhibitor soman (0.4 mM) into the olfactory bulb increased basal norepinephrine levels by 134% of control, suggesting that endogenously released acetylcholine modulates norepinephrine release.	Norepinephrine	212-226	acetylcholinesterase	Rattus norvegicus	22-42
10197057-6	1998	An alternative strategy for directly modulating sympathetic nerve function is to inhibit the biosynthesis of norepinephrine (NE) via inhibition of dopamine-beta-hydroxylase (DBH), the enzyme which catalyzes the conversion of dopamine (DA) to NE in sympathetic nerves.	Norepinephrine	109-123	dopamine beta-hydroxylase	Homo sapiens	147-172
10197057-6	1998	An alternative strategy for directly modulating sympathetic nerve function is to inhibit the biosynthesis of norepinephrine (NE) via inhibition of dopamine-beta-hydroxylase (DBH), the enzyme which catalyzes the conversion of dopamine (DA) to NE in sympathetic nerves.	Norepinephrine	109-123	dopamine beta-hydroxylase	Homo sapiens	174-177
9879729-0	1998	ORL1 receptor-mediated inhibition by nociceptin of noradrenaline release from perivascular sympathetic nerve endings of the rat tail artery.	Norepinephrine	51-64	prepronociceptin	Rattus norvegicus	37-47
9771557-6	1998	T-2 treatment increased 5-hydroxy-3-indoleacetic acid and serotonin throughout the brain, and produced a transient increase in norepinephrine in the nucleus raphe magnus and a temporary decrease in the substantia nigra.	Norepinephrine	127-141	brachyury 2	Rattus norvegicus	0-3
9763638-0	1998	Effects of noradrenaline on intracellular pH in acutely dissociated adult rat hippocampal CA1 neurones.	Norepinephrine	11-24	carbonic anhydrase 1	Rattus norvegicus	90-93
9763638-7	1998	Noradrenaline evoked a concentration-dependent and sustained rise in steady-state pHi and increased rates of pHi recovery from imposed intracellular acid loads.	Norepinephrine	0-13	glucose-6-phosphate isomerase	Rattus norvegicus	82-85
9763638-7	1998	Noradrenaline evoked a concentration-dependent and sustained rise in steady-state pHi and increased rates of pHi recovery from imposed intracellular acid loads.	Norepinephrine	0-13	glucose-6-phosphate isomerase	Rattus norvegicus	109-112
9763638-8	1998	The effects of noradrenaline were not dependent upon the presence of external HCO3- but were blocked by substituting external Na+ with N-methyl-D-glucamine, suggesting that noradrenaline acts to increase steady-state pHi by increasing the activity of the Na+-H+ exchanger.	Norepinephrine	15-28	glucose-6-phosphate isomerase	Rattus norvegicus	217-220
9763638-8	1998	The effects of noradrenaline were not dependent upon the presence of external HCO3- but were blocked by substituting external Na+ with N-methyl-D-glucamine, suggesting that noradrenaline acts to increase steady-state pHi by increasing the activity of the Na+-H+ exchanger.	Norepinephrine	173-186	glucose-6-phosphate isomerase	Rattus norvegicus	217-220
9763638-10	1998	The effects of noradrenaline on steady-state pHi and on rates of pHi recovery from imposed acid loads were mimicked by beta1- and beta2-, but not alpha-, adrenoceptor agonists.	Norepinephrine	15-28	glucose-6-phosphate isomerase	Rattus norvegicus	45-48
9763638-10	1998	The effects of noradrenaline on steady-state pHi and on rates of pHi recovery from imposed acid loads were mimicked by beta1- and beta2-, but not alpha-, adrenoceptor agonists.	Norepinephrine	15-28	glucose-6-phosphate isomerase	Rattus norvegicus	65-68
9763638-11	1998	The beta-adrenoceptor antagonist propranolol blocked the ability of noradrenaline to increase both steady-state pHi and rates of pHi recovery from acid loads.	Norepinephrine	68-81	glucose-6-phosphate isomerase	Rattus norvegicus	112-115
9763638-11	1998	The beta-adrenoceptor antagonist propranolol blocked the ability of noradrenaline to increase both steady-state pHi and rates of pHi recovery from acid loads.	Norepinephrine	68-81	glucose-6-phosphate isomerase	Rattus norvegicus	129-132
9763638-13	1998	The effects of noradrenaline on steady-state pHi and on pHi recovery rates following acid loads were not dependent on changes in [Ca2+]i.	Norepinephrine	15-28	glucose-6-phosphate isomerase	Rattus norvegicus	45-48
9763638-13	1998	The effects of noradrenaline on steady-state pHi and on pHi recovery rates following acid loads were not dependent on changes in [Ca2+]i.	Norepinephrine	15-28	glucose-6-phosphate isomerase	Rattus norvegicus	56-59
9760026-8	1998	The angiotensin AT1 receptor antagonist elicited a fall in plasma noradrenaline values after a 1 Hz stimulation and abolished the increase in plasma noradrenaline levels induced by the 10 (but not 20) Hz stimulation.	Norepinephrine	66-79	angiotensin II receptor type 1	Canis lupus familiaris	16-19
9760026-8	1998	The angiotensin AT1 receptor antagonist elicited a fall in plasma noradrenaline values after a 1 Hz stimulation and abolished the increase in plasma noradrenaline levels induced by the 10 (but not 20) Hz stimulation.	Norepinephrine	149-162	angiotensin II receptor type 1	Canis lupus familiaris	16-19
9648849-1	1998	Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline and is selectively expressed in noradrenergic and adrenergic neurons in the nervous system.	Norepinephrine	72-85	dopamine beta-hydroxylase	Homo sapiens	0-25
9648849-1	1998	Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline and is selectively expressed in noradrenergic and adrenergic neurons in the nervous system.	Norepinephrine	72-85	dopamine beta-hydroxylase	Homo sapiens	27-30
9608581-4	1998	NPY is a 36 amino acid peptide neurotransmitter located in sympathetic and nonsympathetic nerve fibers, as well as in brain structures such as the locus coeruleus, where it is colocalized with norepinephrine.	Norepinephrine	193-207	neuropeptide Y	Homo sapiens	0-3
9608581-5	1998	NPY has been shown to inhibit locus coeruleus neuronal firing, decrease norepinephrine release, and increase postsynaptic noradrenergic signal transduction.	Norepinephrine	72-86	neuropeptide Y	Homo sapiens	0-3
9754635-5	1998	Intraperitoneal injections of various doses (0.2-2 mg kg(-1)) of noradrenaline and adrenaline dose-dependently induced hepatic c-fos and c-jun mRNA levels.	Norepinephrine	65-78	FBJ osteosarcoma oncogene	Mus musculus	127-132
9754635-6	1998	The time-course study showed that there was an increase in c-fos and c-jun mRNA levels within 15 min, which reached a peak at 30 min, and returned to the basal levels 1-2 h after noradrenaline or adrenaline injection (2 mg kg(-1), i.p.).	Norepinephrine	179-192	FBJ osteosarcoma oncogene	Mus musculus	59-64
9754635-23	1998	The results suggest that noradrenaline elicits the hepatic c-fos and c-jun mRNA responses by stimulating alpha1-adrenergic receptors, whereas in the case of adrenaline, this is elicited by stimulating both alpha1- and beta2-adrenergic receptors in mice.	Norepinephrine	25-38	FBJ osteosarcoma oncogene	Mus musculus	59-64
9754639-6	1998	TPA+ (0.3-3 microM) potentiated the contractile responses induced by noradrenaline and ATP, whilst, TPA+ (10 microM) concentration-dependently reduced the agonist-induced contractions.	Norepinephrine	69-82	plasminogen activator, tissue type	Rattus norvegicus	0-3
9590190-10	1998	In stepwise multiple regression analysis, NPY alone explained blood pressure elevation when analyzed with fluid overload and angiotensin II, renin, noradrenaline, and adrenaline levels.	Norepinephrine	148-161	neuropeptide Y	Homo sapiens	42-45
9630349-2	1998	We investigated the potentiating effect of low concentrations of neuropeptide Y (NPY) on the vasoconstriction induced by transmural nerve stimulation (TNS) and noradrenaline (NA) in human saphenous veins.	Norepinephrine	160-173	neuropeptide Y	Homo sapiens	65-79
9630349-2	1998	We investigated the potentiating effect of low concentrations of neuropeptide Y (NPY) on the vasoconstriction induced by transmural nerve stimulation (TNS) and noradrenaline (NA) in human saphenous veins.	Norepinephrine	160-173	neuropeptide Y	Homo sapiens	81-84
9575810-0	1998	Norepinephrine stimulates arachidonic acid release from vascular smooth muscle via activation of cPLA2.	Norepinephrine	0-14	phospholipase A2 group IVA	Rattus norvegicus	97-102
9554647-15	1998	Significant differences between the two groups were found in the norepinephrine dosages at maximum values of S-TnT.	Norepinephrine	65-79	troponin T1, slow skeletal type	Homo sapiens	109-114
9535946-7	1998	Similarly, norepinephrine depressed excitatory synaptic transmission in the NAc by an alpha-adrenergic receptor-dependent mechanism but was without effect on excitatory transmission in the dorsal striatum.	Norepinephrine	11-25	synuclein alpha	Homo sapiens	76-79
9489742-0	1998	Glucocorticoids provoke a shift from alpha2- to alpha1-adrenoreceptor activities in cultured hypothalamic slices leading to opposite noradrenaline effect on corticotropin-releasing hormone release.	Norepinephrine	133-146	corticotropin releasing hormone	Homo sapiens	157-188
9489742-1	1998	We have shown previously that noradrenaline (NA) stimulated or inhibited the release of corticotropin-releasing hormone (CRH) according to the availability of adrenal steroids.	Norepinephrine	30-43	corticotropin releasing hormone	Homo sapiens	88-119
9489742-1	1998	We have shown previously that noradrenaline (NA) stimulated or inhibited the release of corticotropin-releasing hormone (CRH) according to the availability of adrenal steroids.	Norepinephrine	30-43	corticotropin releasing hormone	Homo sapiens	121-124
9458879-1	1998	Neuropeptide Y (NPY) is a vasoconstrictor peptide and a cotransmitter with norepinephrine (NE) in sympathetic nerve terminals and is thought to be involved in sympathetic nerve stimulation (SNS)-induced vasoconstriction.	Norepinephrine	75-89	neuropeptide Y	Homo sapiens	0-14
9458879-1	1998	Neuropeptide Y (NPY) is a vasoconstrictor peptide and a cotransmitter with norepinephrine (NE) in sympathetic nerve terminals and is thought to be involved in sympathetic nerve stimulation (SNS)-induced vasoconstriction.	Norepinephrine	75-89	neuropeptide Y	Homo sapiens	16-19
9597749-3	1998	Norepinephrine, released from sympathetic terminals and acting via beta-adrenoceptors and cAMP, is the main positive regulator of both UCP synthesis and activity.	Norepinephrine	0-14	uncoupling protein 1	Homo sapiens	135-138
9786171-8	1998	Blockade experiments showed that the vasomotor responses to norepinephrine were blocked by prazosin, to NPY by BIBP 3226, acetylcholine by atropin, substance P by RP 67580, and the human alpha-CGRP response by human alpha-CGRP(8-37).	Norepinephrine	60-74	neuropeptide Y	Homo sapiens	104-107
9462871-0	1997	Activation of fos in mouse amygdala by local infusion of norepinephrine or atipamezole.	Norepinephrine	57-71	FBJ osteosarcoma oncogene	Mus musculus	14-17
9364061-1	1997	Prostaglandin E2 (PGE2) mediates the stimulatory effect of norepinephrine (NE) on the secretion of luteinizing hormone-releasing hormone (LHRH), the neuropeptide controlling reproductive function.	Norepinephrine	59-73	gonadotropin releasing hormone 1	Mus musculus	99-136
9364061-1	1997	Prostaglandin E2 (PGE2) mediates the stimulatory effect of norepinephrine (NE) on the secretion of luteinizing hormone-releasing hormone (LHRH), the neuropeptide controlling reproductive function.	Norepinephrine	59-73	gonadotropin releasing hormone 1	Mus musculus	138-142
9359850-4	1997	The cold-induced increase in VEGF mRNA was abolished by surgical sympathetic denervation, but mimicked by administration of noradrenaline or a beta3-adrenoceptor agonist CL316,243, indicating the critical role of the beta-adrenergic pathway in VEGF expression in BAT.	Norepinephrine	124-137	vascular endothelial growth factor A	Rattus norvegicus	29-33
9452885-3	1997	Cell extracts from epidermal suction blister roofs revealed only half the normal activity of phenylethanolamine-N-methyl transferase (PNMT) together with a threefold induction of the norepinephrine-degrading enzyme monoamine oxidase A (MAO-A).	Norepinephrine	183-197	monoamine oxidase A	Homo sapiens	215-234
9368819-14	1997	The difference in beta 3- and alpha 2-adrenoceptor function might explain why noradrenaline induced lipolysis is increased in the two visceral fat depots, as compared to the subcutaneous fat depot.	Norepinephrine	78-91	adrenoceptor beta 3	Homo sapiens	18-50
9329158-5	1997	Coronal sections of rat brain were processed to visualize immunoreactivity for the norepinephrine synthetic enzyme dopamine beta-hydroxylase (DBH), a specific marker for noradrenergic processes.	Norepinephrine	83-97	dopamine beta-hydroxylase	Rattus norvegicus	115-140
9329158-5	1997	Coronal sections of rat brain were processed to visualize immunoreactivity for the norepinephrine synthetic enzyme dopamine beta-hydroxylase (DBH), a specific marker for noradrenergic processes.	Norepinephrine	83-97	dopamine beta-hydroxylase	Rattus norvegicus	142-145
9337215-8	1997	Plasma norepinephrine and endothelin increased by more than fivefold with chronic pacing and remained elevated with AT1 Ang II blockade.	Norepinephrine	7-21	angiogenin	Sus scrofa	120-123
9322991-6	1997	Intravenous leptin increases norepinephrine turnover and sympathetic nerve activity to thermogenic brown adipose tissue.	Norepinephrine	29-43	leptin	Homo sapiens	12-18
9299378-14	1997	In contrast, inhibition of cytosolic phospholipase A2 activity by the specific inhibitor AACOCF3 (1 micromol/l) prevented bradykinin-induced increase in noradrenaline release (S2/S1: 1.09+/-0.15; P&lt;0.01).	Norepinephrine	153-166	phospholipase A2 group IVA	Rattus norvegicus	27-53
9299378-16	1997	Intraneuronal coupling of B2-receptors to phospholipase A2 appears to mediate the facilitatory effect of bradykinin on noradrenaline release in rat heart.	Norepinephrine	119-132	phospholipase A2 group IB	Rattus norvegicus	42-58
9353800-4	1997	Neurochemicals commonly reported in the vLGN and IGL are neuropeptide Y, GABA, enkephalin, and nitric oxide synthase (localized in cells) and serotonin, acetylcholine, histamine, dopamine and noradrenalin (localized in fibers).	Norepinephrine	192-204	immunoglobulin lambda locus	Homo sapiens	49-52
9288945-6	1997	However, maximal cAMP accumulation was significantly reduced in response to various beta3-adrenergic agonists, including endogenous catecholamines, (-)-epinephrine and (-)-norepinephrine, the non-selective agonist (-)-isoproterenol, and the beta3-adrenergic selective agonist CGP 12177A.	Norepinephrine	168-186	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	84-89
9288945-6	1997	However, maximal cAMP accumulation was significantly reduced in response to various beta3-adrenergic agonists, including endogenous catecholamines, (-)-epinephrine and (-)-norepinephrine, the non-selective agonist (-)-isoproterenol, and the beta3-adrenergic selective agonist CGP 12177A.	Norepinephrine	168-186	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	241-246
9253353-0	1997	Influence of circulating epinephrine and norepinephrine on insulin-like growth factor binding protein-1 in humans.	Norepinephrine	41-55	insulin like growth factor binding protein 1	Homo sapiens	59-103
9253353-1	1997	The aim of the present study was to investigate the influence of circulating epinephrine (Epi) and norepinephrine (Norepi) on serum insulin-like growth factor binding protein-1 (IGFBP-1) concentrations.	Norepinephrine	99-113	insulin like growth factor binding protein 1	Homo sapiens	132-176
9253353-1	1997	The aim of the present study was to investigate the influence of circulating epinephrine (Epi) and norepinephrine (Norepi) on serum insulin-like growth factor binding protein-1 (IGFBP-1) concentrations.	Norepinephrine	99-113	insulin like growth factor binding protein 1	Homo sapiens	178-185
9253353-1	1997	The aim of the present study was to investigate the influence of circulating epinephrine (Epi) and norepinephrine (Norepi) on serum insulin-like growth factor binding protein-1 (IGFBP-1) concentrations.	Norepinephrine	115-121	insulin like growth factor binding protein 1	Homo sapiens	132-176
9253353-1	1997	The aim of the present study was to investigate the influence of circulating epinephrine (Epi) and norepinephrine (Norepi) on serum insulin-like growth factor binding protein-1 (IGFBP-1) concentrations.	Norepinephrine	115-121	insulin like growth factor binding protein 1	Homo sapiens	178-185
9253353-7	1997	Norepi resulted in a slight increase in circulating IGFBP-1 (43 +/- 6 to 54 +/- 8 nmol/L, NS).	Norepinephrine	0-6	insulin like growth factor binding protein 1	Homo sapiens	52-59
9247147-1	1997	Mouse brown adipocytes in primary culture were shown to contain high levels of mRNA for interleukin-1alpha (IL-1alpha) which could be further stimulated up to 9-fold by norepinephrine (NE).	Norepinephrine	169-183	interleukin 1 alpha	Mus musculus	88-106
9247147-1	1997	Mouse brown adipocytes in primary culture were shown to contain high levels of mRNA for interleukin-1alpha (IL-1alpha) which could be further stimulated up to 9-fold by norepinephrine (NE).	Norepinephrine	169-183	interleukin 1 alpha	Mus musculus	108-117
9213209-4	1997	The effects of subtype-selective NPY analogs on the stimulation-induced noradrenaline release were studied.	Norepinephrine	72-85	neuropeptide Y	Homo sapiens	33-36
9145932-6	1997	Altogether, MGL mice showed a more restless behavior, a higher rectal temperature, and much higher brain (+17%) and urine (+200%) noradrenaline levels than the MGH animals.	Norepinephrine	130-143	C-type lectin domain family 10, member A	Mus musculus	12-15
9226400-3	1997	NPY (10(-7) M) did not affect either basal tone or spontaneous rhythmic contractions of the isolated intravesical ureter, but significantly enhanced the increases in both tone and frequency of phasic activity elicited by noradrenaline (10(-6) and 10(-5) M).	Norepinephrine	221-234	neuropeptide Y	Equus caballus	0-3
9226400-6	1997	Submaximal concentrations of NPY (10(-8) M) significantly increased the sensitivity of ureteral arteries to noradrenaline.	Norepinephrine	108-121	neuropeptide Y	Equus caballus	29-32
9226400-9	1997	Thus, NPY potentiates the phasic contractions and tone elicited by noradrenaline through Y2-receptors, whereas it both contracts and potentiates noradrenaline vasoconstriction in ureteral arteries via Y1-receptors.	Norepinephrine	67-80	neuropeptide Y	Equus caballus	6-9
9084425-3	1997	The comigration of noradrenaline, secretogranin II, and dopamine-beta-hydroxylase on sucrose-D2O gradient fractions indicates the presence of a population of noradrenaline-containing large dense-cored vesicles (LDCVs).	Norepinephrine	158-171	dopamine beta-hydroxylase	Homo sapiens	56-81
9122267-10	1997	Oxytocin appeared to act to stimulate norepinephrine terminals in the medial basal hypothalamus, which activated NOS by alpha1-adrenergic receptors, because prazocine, an alpha1 receptor blocker, inhibited the LHRH-releasing action of oxytocin.	Norepinephrine	38-52	gonadotropin releasing hormone 1	Rattus norvegicus	210-214
9054387-4	1997	The increase in AA-NAT mRNA is generated by norepinephrine acting through a cAMP mechanism.	Norepinephrine	44-58	aralkylamine N-acetyltransferase	Rattus norvegicus	16-22
9054858-1	1997	BACKGROUND: Although norepinephrine induces cardiac hypertrophy by activating protein kinase A and C through beta- and alpha 1-adrenoceptors, respectively, protein kinase A has been reported to inhibit cell growth in many other cell types.	Norepinephrine	21-35	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	78-154
9054858-1	1997	BACKGROUND: Although norepinephrine induces cardiac hypertrophy by activating protein kinase A and C through beta- and alpha 1-adrenoceptors, respectively, protein kinase A has been reported to inhibit cell growth in many other cell types.	Norepinephrine	21-35	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	78-94
9120070-7	1997	We show here that amnesiac, a neurological mutation, and Dihydroxyphenylalanine decarboxylasetemperature sensitive, a mutation that interferes with synthesis of dopamine, norepinephrine, and serotonin, result in slower heart rate and reduced regularity across a normal range of temperatures for these flies.	Norepinephrine	171-185	amnesiac	Drosophila melanogaster	18-26
9003072-0	1997	Epinephrine and norepinephrine act as potent agonists at the recombinant human dopamine D4 receptor.	Norepinephrine	16-30	dopamine receptor D4	Homo sapiens	79-99
9039093-1	1997	Neuropeptide Y coexists with norepinephrine in sympathetic nerves and is coreleased into the circulation on sympathetic activation.	Norepinephrine	29-43	neuropeptide Y	Homo sapiens	0-14
9241547-0	1997	Effect of the alpha-1 adrenoceptor blocker on tissue norepinephrine contents in human benign prostatic hyperplasia.	Norepinephrine	53-67	adrenoceptor alpha 1D	Homo sapiens	14-21
8952593-8	1996	Atrial natriuretic factor, however, increased at 7 and 14 days of servo-controlled norepinephrine, and plasma renin activity increased on day 14 of norepinephrine infusion.	Norepinephrine	83-97	natriuretic peptide A	Canis lupus familiaris	0-25
8922421-3	1996	It has been shown previously that Phox2 is such a homeodomain protein, expressed exclusively in differentiated groups of neurons or their precursors, and that its expression correlated with that of the noradrenaline synthesis enzyme dopamine-beta-hydroxylase.	Norepinephrine	202-215	dopamine beta-hydroxylase	Homo sapiens	233-258
9004162-3	1996	In this study, by means of binding assays on cardiac membranes or by evaluating contractility and cAMP levels of isolated rat atria in the presence of IL-2, we demonstrate that IL-2 may indirectly stimulate beta-adrenergic-mediated function by triggering the presynaptic release of norepinephrine (NE) on isolated rat atria.	Norepinephrine	282-296	interleukin 2	Rattus norvegicus	177-181
8930173-9	1996	Norepinephrine displayed, respectively, 18- and 31-fold selectivity for the high affinity state of the alpha-2C adrenoceptor as compared to alpha-2A- or alpha-2B adrenoceptors, and was &gt; 100,000- fold selective over platelet I1-imidazoline sites.	Norepinephrine	0-14	nischarin	Homo sapiens	228-230
8921301-3	1996	The modulation of IAHP by noradrenaline has previously been shown to be mediated by beta 1 receptors, cyclic AMP and protein kinase A, but not by alpha receptors.	Norepinephrine	26-39	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	117-133
8897640-3	1996	The aim of the present work was to investigate BNP and CNP effects on the uptake and release of norepinephrine (NE) in rat hypothalamic slices incubated in vitro.	Norepinephrine	96-110	2',3'-cyclic nucleotide 3' phosphodiesterase	Rattus norvegicus	55-58
8790370-4	1996	Thus, connexin32-containing gap junctions are essential in mouse liver for maximal intercellular propagation of the noradrenaline signal from the periportal (upstream) area, where it is received from sympathetic nerve endings, to perivenous (downstream) hepatocytes.	Norepinephrine	116-129	gap junction protein, beta 1	Mus musculus	6-16
8828539-2	1996	Neuropeptide Y (NPY) is co-localized with norepinephrine in sympathetic perivascular nerves.	Norepinephrine	42-56	neuropeptide Y	Homo sapiens	0-14
8828539-2	1996	Neuropeptide Y (NPY) is co-localized with norepinephrine in sympathetic perivascular nerves.	Norepinephrine	42-56	neuropeptide Y	Homo sapiens	16-19
8828539-3	1996	NPY is released with norepinephrine on sympathetic nerve stimulation and produces long-lasting vasoconstriction of the nasal vascular bed.	Norepinephrine	21-35	neuropeptide Y	Homo sapiens	0-3
8898322-4	1996	Decreased availability of estrogen may also increase the levels of neuropeptide Y, leading to decreased release of noradrenaline from the ventromedial hypothalamus.	Norepinephrine	115-128	neuropeptide Y	Homo sapiens	67-81
8898322-5	1996	The increased noradrenaline content may increase the concentration of galanin, which will decrease the circulating levels of insulin and increase the pace of transcription of the neuropeptide Y gene.	Norepinephrine	14-27	neuropeptide Y	Homo sapiens	179-193
8710943-3	1996	During neonatal cardiomyocyte hypertrophy induced by norepinephrine or spontaneous contraction, changes in the expression of a ribosomal DNA transcription factor, UBF, correlated with increased rates of ribosome biogenesis.	Norepinephrine	53-67	upstream binding transcription factor	Homo sapiens	163-166
8964116-6	1996	Incubation with norepinephrine or the alpha2-adrenergic agonist BHT 920 also caused dose-dependent increases in nitrite production, which were blocked by the B2-receptor antagonist HOE 140.	Norepinephrine	16-30	bradykinin receptor B2	Homo sapiens	158-169
8817112-5	1996	Beta 3-adrenergic receptor function was investigated by measuring lipolysis in isolated visceral white fat cells incubated with noradrenaline (natural ligand) or (CGP) 12,177 (selective beta 3-agonist).	Norepinephrine	128-141	adrenoceptor beta 3	Homo sapiens	0-26
8818542-7	1996	The expression of the IL-1A gene in cultured brown adipocytes was increased 6-8-fold by IL-1 beta, TNF-alpha, LPS and by noradrenaline.	Norepinephrine	121-134	interleukin 1 alpha	Mus musculus	22-27
8641736-9	1996	Thus, these data show that norepinephrine-mediated downregulation of AT1 receptors is associated with a parallel decrease in AT1 mRNA and Ang II stimulation of norepinephrine transporter mRNA and involves the alpha1a-adrenergic receptor in neurons of WKY brain.	Norepinephrine	27-41	solute carrier family 6 member 2	Rattus norvegicus	160-186
8829205-0	1996	Enhancement of brain noradrenaline and dopamine turnover by thyrotropin-releasing hormone and its analogue NS-3 in mice and rats.	Norepinephrine	21-34	mal, T-cell differentiation protein	Rattus norvegicus	107-111
8636412-6	1996	The induction of hsp70 mRNA by either norepinephrine or by phorbol dibutyrate was blunted in aortas from old (24-27 mo) rats whereas c-fos responses were not diminished in the older vessels.	Norepinephrine	38-52	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	17-22
8911654-7	1996	For example, plasma NPY, a peptide co-localized with norepinephrine in the sympathetic nervous system, is low in patients with FM.	Norepinephrine	53-67	neuropeptide Y	Homo sapiens	20-23
9053060-1	1996	Corticotropin-releasing hormone administration into the neostriatum was shown to increase the level of corticosterone in the blood, as well as adrenaline and noradrenaline contents in the adrenal glands.	Norepinephrine	158-171	corticotropin releasing hormone	Homo sapiens	0-31
8755013-2	1996	The selective alpha-1 blockers reduce peripheral vascular resistance by blocking the alpha-1 receptors and preventing norepinephrine from reaching them.	Norepinephrine	118-132	adrenoceptor alpha 1D	Homo sapiens	14-21
8780011-5	1996	Noradrenaline enhanced the levels of proenkephalin mRNA in a concentration-dependent manner.	Norepinephrine	0-13	proenkephalin	Rattus norvegicus	37-50
8780011-9	1996	However, concentrations of noradrenaline that produced a maximal increase in cAMP caused only submaximal elevations of proenkephalin mRNA.	Norepinephrine	27-40	proenkephalin	Rattus norvegicus	119-132
8780011-10	1996	This discrepancy was explained by the finding that noradrenaline increased the expression of the proenkephalin gene also via alpha 1-adrenoceptors.	Norepinephrine	51-64	proenkephalin	Rattus norvegicus	97-110
8627569-8	1996	It is concluded that clonidine acts on alpha-1 adrenoceptors as a partial agonist, causing relaxation of the mesenteric artery precontracted with norepinephrine or contraction of preparations precontracted with endothelin.	Norepinephrine	146-160	adrenoceptor alpha 1D	Homo sapiens	39-46
8848409-1	1996	Neuropeptide Y (NPY) has been recently characterized as a circulating vasoconstrictor peptide which is co-stored with noradrenaline in sympathetic neurons.	Norepinephrine	118-131	neuropeptide Y	Homo sapiens	0-20
8601816-1	1996	The present study demonstrates that chronic, but not acute, adminstration of several different classes of antidepressants, including serotonin- and norepinephrine-selective reuptake inhibitors, increases the expression of cAMP response element binding protein (CREB) mRNA in rat hippocampus.	Norepinephrine	148-162	cAMP responsive element binding protein 1	Rattus norvegicus	222-259
8601816-1	1996	The present study demonstrates that chronic, but not acute, adminstration of several different classes of antidepressants, including serotonin- and norepinephrine-selective reuptake inhibitors, increases the expression of cAMP response element binding protein (CREB) mRNA in rat hippocampus.	Norepinephrine	148-162	cAMP responsive element binding protein 1	Rattus norvegicus	261-265
8740147-8	1996	In lungs perfused with 1 nmol/l 3H-noradrenaline (COMT inhibited), 10, 30 and 300 nmol/l amezinium caused 58%, 76% and 74% inhibition of noradrenaline deamination, respectively, and 30, 300 and 3000 nmol/l debrisoquine caused 56%, 89% and 96% inhibition of noradrenaline deamination, respectively.	Norepinephrine	35-48	catechol-O-methyltransferase	Rattus norvegicus	50-54
8935715-5	1996	Long-term treatment with 5-HT-uptake inhibitors and noradrenaline-uptake inhibitor produces desensitization of 5-HT1A autoreceptors and alpha 2-heteroreceptors, respectively, which may be related therapeutically to the delayed onset of the effects of antidepressants.	Norepinephrine	52-65	5-hydroxytryptamine receptor 1A	Homo sapiens	111-117
8935709-3	1996	Monoamine oxidase was inhibited and, in experiments with noradrenaline, catechol-O-methyltransferase was also inhibited.	Norepinephrine	57-70	catechol-O-methyltransferase	Rattus norvegicus	72-100
8678123-1	1996	The monoamine oxidases (MAO-A and MAO-B) are the enzymes primarily responsible for the degradation of amine neurotransmitters, such as dopamine, norepinephrine, and serotonin.	Norepinephrine	145-159	monoamine oxidase A	Homo sapiens	24-29
8851174-8	1996	The respective contributions of the beta 1- and the beta 3-subtypes to the production of cAMP were resolved by an Eadie-Hofstee computer analysis of isoproterenol and norepinephrine concentration-response curve of adenylyl cyclase activity.	Norepinephrine	167-181	hemoglobin, beta adult major chain	Mus musculus	36-42
8851174-11	1996	In addition, approximately 84% of the maximal norepinephrine-stimulated lipolysis was mediated by the beta 3-adrenoceptor in fully differentiated adipocytes.	Norepinephrine	46-60	adrenergic receptor, beta 3	Mus musculus	102-121
8591854-0	1996	Norepinephrine reverses the effects of activin A on DNA synthesis and apoptosis in cultured rat hepatocytes.	Norepinephrine	0-14	inhibin subunit beta A	Rattus norvegicus	39-48
8917909-2	1996	Generally, in anestrous ewes beta-endorphin and/or corticoliberin significantly change extracellular concentrations of monoamine metabolites in the MBH-ME, but in estrous ewes both beta-endorphin and CRF alters also dopamine, noradrenaline and serotonin levels.	Norepinephrine	226-239	corticotropin releasing hormone	Homo sapiens	51-65
8722501-1	1996	Neuropeptide Y is a sympathetic co-neurotransmitter released with noradrenaline upon sympathetic nerve stimulation.	Norepinephrine	66-79	neuropeptide Y	Homo sapiens	0-14
8622571-2	1996	Previous results have shown that both dopamine (DA) and norepinephrine (NE) stimulate GnRH secretion in GT1 neuronal cell lines.	Norepinephrine	56-70	gonadotropin releasing hormone 1	Mus musculus	86-90
8787934-3	1996	Clear inter-individual variations in the adipocyte lipolytic adrenoceptor sensitivity (pD2) for noradrenaline were observed in dose-response experiments (i.e., about 4 log units).	Norepinephrine	96-109	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	87-90
8787934-4	1996	An inverse and independent correlation was found between the 24-hour systolic blood pressure and pD2 for noradrenaline (r = -0.67, p &lt; 0.01).	Norepinephrine	105-118	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	97-100
8821761-5	1995	All these results suggest that norepinephrine, through stimulation of both alpha 1- and alpha 2- (alpha 2A- and alpha 2B/2C-) adrenoceptor subtypes, is involved in producing fever in response to bacterial LPS.	Norepinephrine	31-45	alpha-2A adrenergic receptor	Oryctolagus cuniculus	98-138
9019375-7	1995	Noradrenaline and histamine evoked concentration dependent constrictions which were potentiated by neuropeptide Y (3 x 10(-7) M).	Norepinephrine	0-13	neuropeptide Y	Oryctolagus cuniculus	99-113
9053735-5	1995	In the presence of indometacin and yohimbine, sulprostone (an agonist at EP1/EP3 receptors) and misoprostol (an agonist at EP2/EP3 receptors) reduced the noradrenaline overflow evoked by stimulation at 3 Hz maximally by about 80% (EC50: 6 nmol/l and 11 nmol/l, respectively).	Norepinephrine	154-167	prostaglandin E receptor 2	Rattus norvegicus	123-140
8801271-1	1995	Dopamine-beta-hydroxylase (D beta H) is the enzyme responsible for intraneural conversion of dopamine to norepinephrine.	Norepinephrine	105-119	dopamine beta-hydroxylase	Homo sapiens	0-25
8697051-7	1995	The relative order of affinity of the various fat cell ARs for the physiological amines defined in binding studies and in vitro assays is alpha 2 &gt; beta 1 &gt; or = beta 2 &gt; beta 3 for norepinephrine and alpha 2 &gt; beta 2 &gt; beta 1 &gt; beta 3 for epinephrine.	Norepinephrine	191-205	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	180-186
8739199-7	1995	In the brain of untreated OB rats, the concentrations of noradrenaline were reduced; IL-2 treatment significantly increased the concentrations of noradrenaline and serotonin.	Norepinephrine	146-159	interleukin 2	Rattus norvegicus	85-89
7498294-3	1995	The alpha 1-adrenoceptor antagonist prazosin antagonized the contraction elicited by noradrenaline and phenylephrine.	Norepinephrine	85-98	adrenoceptor alpha 1D	Homo sapiens	4-11
7580872-3	1995	S-antigen immunoreactive pinealocytes were shown to respond to norepinephrine stimulation with an elevation of the intracellular free calcium concentration ([Ca2+]i).	Norepinephrine	63-77	S-antigen visual arrestin	Rattus norvegicus	0-9
7631894-4	1995	A net uptake of norepinephrine was found in resting legs at sea level (0.28 +/- 0.05 nmol/min) and with acute exposure (0.07 +/- 0.06 nmol/min); however, a significant switch to net leg norepinephrine release was observed with chronic altitude exposure (0.51 +/- 0.11 nmol/min).	Norepinephrine	16-30	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	60-63
7631894-5	1995	With exercise, a net release of norepinephrine by the leg occurred across all conditions with chronic exposure, again eliciting the greatest values (5.3 +/- 0.6, 8.0 +/- 1.7, and 14.4 +/- 3.1 nmol/min for sea level, acute, and chronic exposure, respectively).	Norepinephrine	32-46	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	205-208
8529072-8	1995	In renal cortical membranes, intrarenal administration of norepinephrine for 3-4 h increases PLC beta expression and activity but has no effect on PLC gamma activity.	Norepinephrine	58-72	heparan sulfate proteoglycan 2	Homo sapiens	93-96
7621895-1	1995	The beta 3-adrenoceptor is a G protein-coupled receptor which mediates metabolic functions of the endogenous catecholamines epinephrine and norepinephrine.	Norepinephrine	140-154	adrenoceptor beta 3	Homo sapiens	4-23
7635178-5	1995	The delta-opioid receptor agonist, [D-Pen2,D-Pen5]enkephalin, had no effect on resting tension but potentiated the contractions induced by noradrenaline; these effects were abolished by naltrindol.	Norepinephrine	139-152	proenkephalin	Rattus norvegicus	50-60
7713937-2	1995	We studied the regulation of ribosomal RNA synthesis and the levels of RNA polymerase I and the ribosomal DNA transcription factor, UBF, during norepinephrine-induced hypertrophy of contraction-arrested neonatal cardiomyocytes in culture.	Norepinephrine	144-158	upstream binding transcription factor	Homo sapiens	96-135
7713937-5	1995	Northern blots demonstrated norepinephrine-induced increases in UBF mRNA in neonatal cardiomyocytes indicating that the response was regulated, at least in part, at the pretranslational stage.	Norepinephrine	28-42	upstream binding transcription factor	Homo sapiens	64-67
7713937-9	1995	These results implicate UBF as a possible regulatory factor of the accelerated rDNA transcription observed during norepinephrine-mediated cardiomyocyte hypertrophy.	Norepinephrine	114-128	upstream binding transcription factor	Homo sapiens	24-27
7630431-0	1995	Evidence for saturation of catechol-O-methyltransferase by low concentrations of noradrenaline in perfused lungs of rats.	Norepinephrine	81-94	catechol-O-methyltransferase	Rattus norvegicus	27-55
7630431-1	1995	Previous studies on the pulmonary removal and metabolism of catecholamines in rat lungs have shown that, when the lungs are perfused with a low concentration (1 nmol/l) of noradrenaline, the amine is metabolized by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO), but is predominantly O-methylated, and the activities of COMT and MAO are 0.357 min-1 and 0.186 min-1, respectively.	Norepinephrine	172-185	catechol-O-methyltransferase	Rattus norvegicus	215-243
7630431-1	1995	Previous studies on the pulmonary removal and metabolism of catecholamines in rat lungs have shown that, when the lungs are perfused with a low concentration (1 nmol/l) of noradrenaline, the amine is metabolized by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO), but is predominantly O-methylated, and the activities of COMT and MAO are 0.357 min-1 and 0.186 min-1, respectively.	Norepinephrine	172-185	catechol-O-methyltransferase	Rattus norvegicus	245-249
7630431-1	1995	Previous studies on the pulmonary removal and metabolism of catecholamines in rat lungs have shown that, when the lungs are perfused with a low concentration (1 nmol/l) of noradrenaline, the amine is metabolized by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO), but is predominantly O-methylated, and the activities of COMT and MAO are 0.357 min-1 and 0.186 min-1, respectively.	Norepinephrine	172-185	catechol-O-methyltransferase	Rattus norvegicus	337-341
7525897-1	1994	Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine, and is expressed specifically in neurons and neuroendocrine cells that release norepinephrine and epinephrine.	Norepinephrine	72-86	dopamine beta-hydroxylase	Rattus norvegicus	27-30
7525897-1	1994	Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine, and is expressed specifically in neurons and neuroendocrine cells that release norepinephrine and epinephrine.	Norepinephrine	167-181	dopamine beta-hydroxylase	Rattus norvegicus	0-25
7525897-1	1994	Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine, and is expressed specifically in neurons and neuroendocrine cells that release norepinephrine and epinephrine.	Norepinephrine	167-181	dopamine beta-hydroxylase	Rattus norvegicus	27-30
7842524-2	1994	In order to further investigate the postnatal development of this neurotransmitter system, especially in relation to the critical period, we used a polyclonal antibody against dopamine-beta-hydroxylase to localize noradrenaline-containing afferents in visual cortex of kittens of various ages from birth to adulthood.	Norepinephrine	214-227	dopamine beta-hydroxylase	Homo sapiens	176-201
7719704-2	1994	DBH is required for conversion of dopamine to norepinephrine, the third step in catecholamine biosynthesis.	Norepinephrine	46-60	dopamine beta-hydroxylase	Homo sapiens	0-3
7626916-11	1994	In conclusion, in porcine intrapulmonary arteries, L-NAME inhibited noradrenaline induced endothelium dependent reduction in tone, which was also inhibited by alpha-1 and alpha-2 antagonists.	Norepinephrine	68-81	adrenoceptor alpha 1D	Homo sapiens	159-166
7519662-1	1994	Monoamine oxidase (MAO) A (EC 1.4.3.4) oxidizes norepinephrine and serotonin and is expressed in a cell type-specific manner.	Norepinephrine	48-62	monoamine oxidase A	Homo sapiens	0-25
7800657-3	1994	Moreover, the inhibitor of dopamine-beta-hydroxylase, disulfiram, caused significant decrease in brain noradrenaline (NA) and significant increase in brain dopamine (DA) contents.	Norepinephrine	103-116	dopamine beta-hydroxylase	Homo sapiens	27-52
7801776-4	1994	IC50 and K1 values of l-norepinephrine (NE), dl-propranol (Pro), d-timolol (d-Tim), and l-Tim competed for the [3H]DHA binding sites were 171 +/- 10, 10.3 +/- 4.3, 6.5 +/- 2.1, 0.40 +/- 0.23 nmol.L-1 and 113 +/- 6, 6.3 +/- 2.8, 4.0 +/- 1.3, 0.25 +/- 0.14 nmol.L-1, respectively.	Norepinephrine	22-38	L1 cell adhesion molecule	Mus musculus	196-218
7969507-0	1994	Pre- and postganglionic stimulation-induced noradrenaline overflow is markedly facilitated by a prejunctional beta 2-adrenoceptor-mediated control mechanism in the pithed rat.	Norepinephrine	44-57	adrenoceptor beta 2	Rattus norvegicus	110-129
8064781-1	1994	Neuropeptide Y (NPY) has been recently characterised as a circulating vasoconstrictor peptide which is co-stored with noradrenaline (NA) in sympathetic neurons.	Norepinephrine	118-131	neuropeptide Y	Homo sapiens	0-20
7509734-10	1994	Norepinephrine and epinephrine infusions increased IGFBP-1 levels significantly (2- to 5-fold) in fetal plasma within 8-12 h, and the time course pattern of elevation of plasma IGFBP-1 levels was similar to that observed in prolonged hypoxia.	Norepinephrine	0-14	insulin-like growth factor-binding protein 1	Ovis aries	51-58
7509734-10	1994	Norepinephrine and epinephrine infusions increased IGFBP-1 levels significantly (2- to 5-fold) in fetal plasma within 8-12 h, and the time course pattern of elevation of plasma IGFBP-1 levels was similar to that observed in prolonged hypoxia.	Norepinephrine	0-14	insulin-like growth factor-binding protein 1	Ovis aries	177-184
7509734-11	1994	After 24 h of either norepinephrine or epinephrine infusion, IGFBP-1 mRNA levels in the liver of fetuses were increased significantly (5- to 7-fold) compared to those of vehicle infused fetuses.	Norepinephrine	21-35	insulin-like growth factor-binding protein 1	Ovis aries	61-68
8138937-0	1994	Different metabolism of norepinephrine and epinephrine by catechol-O-methyltransferase and monoamine oxidase in rats.	Norepinephrine	24-38	catechol-O-methyltransferase	Rattus norvegicus	58-86
11224250-0	1994	Noradrenaline-serotonin interactions in the anxiolytic effects of 5-HT(1A) agonists.	Norepinephrine	0-13	5-hydroxytryptamine receptor 1A	Homo sapiens	66-73
8046992-0	1994	Lead (Pb) alters the norepinephrine-induced secretion of luteinizing hormone releasing hormone from the median eminence of adult male rats in vitro.	Norepinephrine	21-35	gonadotropin releasing hormone 1	Rattus norvegicus	57-94
7506268-4	1993	The secretion of GnRH from GT1 cells is stimulated by both norepinephrine and dopamine respectively via beta 1-adrenergic and D1-dopaminergic receptors.	Norepinephrine	59-73	beta-1,4-galactosyltransferase 1	Homo sapiens	27-30
8255183-2	1993	infusions of norepinephrine (NE) on plasma LH and on LHRH mRNA levels in the organum vasculosum of the lamina terminalis (OVLT) and in neurons located in the rostral (r), middle (m) and caudal (c) preoptic areas (POA) of ovariectomized, estrogen-treated rats.	Norepinephrine	13-27	gonadotropin releasing hormone 1	Rattus norvegicus	53-57
8284028-6	1993	In the adrenal medulla the DARP signal was found in segregated cells forming clusters similar to the homotypic distribution of norepinephrine and epinephrine cells.	Norepinephrine	127-141	ankyrin repeat domain 23	Homo sapiens	27-31
8513972-5	1993	In all three groups, subcutaneous insulin activated the sympathetic nervous system (approximately 30% increase in norepinephrine concentration).	Norepinephrine	114-128	insulin	Bos taurus	34-41
8224732-4	1993	In the periphery, NPY coexists with noradrenaline (NA) in perivascular sympathetic fibers.	Norepinephrine	36-49	neuropeptide Y	Homo sapiens	18-21
8103576-3	1993	This effect of neurotensin was inhibited by stimulation of alpha 2-adrenoceptors: noradrenaline, clonidine, xylazine or dexmedetomidine (alpha 2-adrenoceptor agonists) inhibited neurotensin-induced release of acetycholine (ACh) as well as the contractions, while CH-38083 or yohimbine (alpha 2-adrenoceptor antagonist) prevented this inhibitory effect.	Norepinephrine	82-95	neurotensin/neuromedin N	Cavia porcellus	15-26
8103576-4	1993	Our findings suggest that neurotensin may play a neuromodulatory role in the regulation of cholinergic neuronal activity in the gut and this modulatory effect is continuously controlled by the tonic activity of the sympathetic nervous system: endogenous noradrenaline release is capable of reducing the release of ACh and the consequent contraction of the gut enhanced by neurotensin.	Norepinephrine	254-267	neurotensin/neuromedin N	Cavia porcellus	26-37
8103576-4	1993	Our findings suggest that neurotensin may play a neuromodulatory role in the regulation of cholinergic neuronal activity in the gut and this modulatory effect is continuously controlled by the tonic activity of the sympathetic nervous system: endogenous noradrenaline release is capable of reducing the release of ACh and the consequent contraction of the gut enhanced by neurotensin.	Norepinephrine	254-267	neurotensin/neuromedin N	Cavia porcellus	372-383
8106131-2	1993	This receptor can be stimulated with catecholamines or selective pharmacological beta 3-adrenoceptor agonists and it fulfils similar function of norepinephrine in rodent and dog adipose tissue.	Norepinephrine	145-159	adrenoceptor beta 3	Canis lupus familiaris	81-100
8224066-11	1993	Noradrenaline, the alpha 1-agonist PHE and the beta-agonist ISO exerted a weak depressant action on high-frequency maintained activity, but during low-frequency single spike activity and/or burst activity a facilitatory effect was evident, which prevented the generation of burst discharges and slightly increased single spike firing.	Norepinephrine	0-13	adrenoceptor alpha 1D	Homo sapiens	19-26
8464343-4	1993	Furthermore, only in SHR, 10 U/ml erythropoietin enhanced contraction induced by 10(-7) M norepinephrine (+145% vs +121%, p &lt; 0.04) and reduced relaxation by 10(-7) M acetylcholine (-69% vs -96%, p &lt; 0.05).	Norepinephrine	90-104	erythropoietin	Rattus norvegicus	34-48
1385204-1	1992	Recent studies in this laboratory have demonstrated that intramuscular injection of the irreversible acetylcholinesterase (AChE) inhibitor, soman (pinacolylmethylphosphonofluoridate), produces a rapid (1-2 h) and profound depletion (70% of control) of norepinephrine (NE) in the olfactory bulb and forebrain.	Norepinephrine	252-266	acetylcholinesterase	Rattus norvegicus	101-121
1385204-1	1992	Recent studies in this laboratory have demonstrated that intramuscular injection of the irreversible acetylcholinesterase (AChE) inhibitor, soman (pinacolylmethylphosphonofluoridate), produces a rapid (1-2 h) and profound depletion (70% of control) of norepinephrine (NE) in the olfactory bulb and forebrain.	Norepinephrine	252-266	acetylcholinesterase	Rattus norvegicus	123-127
1382062-1	1992	Dopamine beta-hydroxylase, the enzyme which converts dopamine to norepinephrine, is expressed in a cell type-restricted pattern in neuroendocrine tissue.	Norepinephrine	65-79	dopamine beta-hydroxylase	Rattus norvegicus	0-25
1383833-7	1992	When rats were pretreated with the beta 2-adrenoceptor agonist clenbuterol (0.3 mg.kg-1, s.c., twice daily, 14 days), a treatment which desensitizes beta-adrenoceptor-mediated facilitation of noradrenaline release (Kazanietz and Enero 1989), the facilitatory effect of forskolin and IBMX in the presence of yohimbine was abolished.	Norepinephrine	192-205	adrenoceptor beta 2	Rattus norvegicus	35-54
1326853-2	1992	Angiotensin converting enzyme (ACE)-inhibition by benazeprilat increased nerve stimulation (2 Hz, 4 min)-evoked noradrenaline (NA) overflow (+ 21 +/- 5%) with alpha-adrenoceptors intact, but reduced NA overflow (- 18 +/- 6%) when alpha-adrenoceptors were blocked.	Norepinephrine	112-125	angiotensin I converting enzyme	Canis lupus familiaris	0-29
1326853-2	1992	Angiotensin converting enzyme (ACE)-inhibition by benazeprilat increased nerve stimulation (2 Hz, 4 min)-evoked noradrenaline (NA) overflow (+ 21 +/- 5%) with alpha-adrenoceptors intact, but reduced NA overflow (- 18 +/- 6%) when alpha-adrenoceptors were blocked.	Norepinephrine	112-125	angiotensin I converting enzyme	Canis lupus familiaris	31-34
1407001-1	1992	The uptake and subsequent metabolism by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO) of dopamine, adrenaline, isoprenaline and noradrenaline in isolated perfused lungs of rats has been examined.	Norepinephrine	146-159	catechol-O-methyltransferase	Rattus norvegicus	40-68
1407001-1	1992	The uptake and subsequent metabolism by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO) of dopamine, adrenaline, isoprenaline and noradrenaline in isolated perfused lungs of rats has been examined.	Norepinephrine	146-159	catechol-O-methyltransferase	Rattus norvegicus	70-74
1407001-2	1992	In lung preparations in which COMT and MAO were inhibited, the uptake of 3H-labelled dopamine, (-)-adrenaline and (-)-noradrenaline, but not (+/-)-isoprenaline, was reduced by cocaine (10 or 100 mumol/l).	Norepinephrine	114-131	catechol-O-methyltransferase	Rattus norvegicus	30-34
1407001-5	1992	In lung preparations with COMT and MAO intact, dopamine and noradrenaline were removed from the circulation (50% and 32%, respectively) and mainly metabolized.	Norepinephrine	60-73	catechol-O-methyltransferase	Rattus norvegicus	26-30
1407001-7	1992	In lung preparations in which only MAO was inhibited, the rank order of COMT activity for O-methylation of the amines was dopamine much much greater than noradrenaline greater than or equal to adrenaline (kCOMT values: 4.98 min-1, 0.357 min-1 and 0.234 min-1, respectively).	Norepinephrine	154-167	catechol-O-methyltransferase	Rattus norvegicus	72-76
1407001-8	1992	If dopamine or adrenaline are perfused through the pulmonary circulation in isolated lungs of the rat, they are taken up and then metabolized by COMT and MAO, as also occurs for noradrenaline.	Norepinephrine	178-191	catechol-O-methyltransferase	Rattus norvegicus	145-149
1279652-5	1992	The actions of both intrathecal norepinephrine (0.025 microgram) and intrathecal clonidine (0.025 microgram) were significantly attenuated when substance P (5 micrograms) was given intrathecally 55 and 45 min.	Norepinephrine	32-46	tachykinin 1	Mus musculus	144-155
1572308-1	1992	We previously reported that the injection of neostigmine, an inhibitor of acetylcholinesterase, into the third cerebral ventricle of fasted rats produced hyperglycemia associated with the secretion of epinephrine and norepinephrine.	Norepinephrine	217-231	acetylcholinesterase	Rattus norvegicus	74-94
1381830-8	1992	In the temporal artery, NPY did not induce contraction but potentiated the vasoconstrictor response to noradrenaline.	Norepinephrine	103-116	neuropeptide Y	Homo sapiens	24-27
1468602-6	1992	The secretion of GnRH is stimulated by depolarization and by the neurotransmitter norepinephrine.	Norepinephrine	82-96	gonadotropin releasing hormone 1	Mus musculus	17-21
1350995-4	1992	The beta 2-adrenoceptor antagonist, ICI 118,551, was approximately 3000 fold more potent than the beta 1-adrenoceptor antagonist, atenolol, in blocking the effects of fenoterol (pA2 9.32 and 5.88 respectively) and 400 times more potent in antagonising noradrenaline (pA2 8.96 vs. 6.23).	Norepinephrine	252-265	adrenoceptor beta 2	Rattus norvegicus	4-23
1582134-8	1992	Plasma noradrenaline fell by 20% (P less than 0.02) and arterial glucose by 3% (P less than 0.005) during the NPY infusion.	Norepinephrine	7-20	neuropeptide Y	Homo sapiens	110-113
1582134-10	1992	The results also suggest that elevated plasma NPY-levels may be associated with changes in the turnover of noradrenaline and glucose.	Norepinephrine	107-120	neuropeptide Y	Homo sapiens	46-49
1535692-2	1992	The initial rate of uptake of noradrenaline was measured in isolated lungs of rats perfused with 2 nmol/l 3H-(-)-noradrenaline for 2 min with monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT) inhibited, in the absence or presence of drugs that are substrates or inhibitors of Uptake1 or Uptake2 or of alterations in the ionic composition of the Krebs solution.	Norepinephrine	30-43	catechol-O-methyltransferase	Rattus norvegicus	170-198
1535692-2	1992	The initial rate of uptake of noradrenaline was measured in isolated lungs of rats perfused with 2 nmol/l 3H-(-)-noradrenaline for 2 min with monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT) inhibited, in the absence or presence of drugs that are substrates or inhibitors of Uptake1 or Uptake2 or of alterations in the ionic composition of the Krebs solution.	Norepinephrine	30-43	catechol-O-methyltransferase	Rattus norvegicus	200-204
1596693-0	1992	Inhibition of neuropeptide Y-induced potentiation of noradrenaline-induced vasoconstriction by PP56 (D-myo-inositol 1,2,6-tris-phosphate).	Norepinephrine	53-66	neuropeptide Y	Oryctolagus cuniculus	14-28
1596693-4	1992	The potentiating effect of NPY on noradrenaline-induced contraction was present in endothelium-denuded femoral arteries.	Norepinephrine	34-47	neuropeptide Y	Oryctolagus cuniculus	27-30
1596693-6	1992	The potentiating effect of NPY on noradrenaline-induced contraction was antagonized by PP56 (D-myo-inositol 1,2,6-trisphosphate) in low concentrations (down to 0.1 nM).	Norepinephrine	34-47	neuropeptide Y	Oryctolagus cuniculus	27-30
1425026-2	1992	The interaction is amongst noradrenaline and other neurotransmitters such as GABA (gamma-aminobutyric acid), opiates, serotonin and excitatory amino acids (N-methyl-D-aspartate, NMDA) on LHRH neuronal activity are complex.	Norepinephrine	27-40	gonadotropin releasing hormone 1	Rattus norvegicus	187-191
1425026-3	1992	GABA and opiates suppress the presynaptic release of noradrenaline but only GABA also directly affects the responsiveness of LHRH neurons to noradrenaline.	Norepinephrine	141-154	gonadotropin releasing hormone 1	Rattus norvegicus	125-129
1425026-4	1992	Morphine induces the release of serotonin which either directly or indirectly via other neurotransmitters (e.g. dopamine) sensitizes LHRH neurons to the stimulatory effects of noradrenaline.	Norepinephrine	176-189	gonadotropin releasing hormone 1	Rattus norvegicus	133-137
1425026-8	1992	Normally, LHRH message levels increase about the time of increased noradrenaline secretion just before the LH surge.	Norepinephrine	67-80	gonadotropin releasing hormone 1	Rattus norvegicus	10-14
1361458-6	1992	Moreover, NPY activates postsynaptic messenger pathways that complement and reinforce those affected by norepinephrine, which is another major neuroregulator of LHRH secretion and which is released as a cotransmitter with NPY in the median eminence.	Norepinephrine	104-118	gonadotropin releasing hormone 1	Rattus norvegicus	161-165
1609114-5	1992	In the central nervous system of man MAO-A seems to be mainly involved in the metabolism of 5 HT and noradrenaline, whereas 2-phenylethylamine and probably dopamine are predominantly deaminated by MAO-B.	Norepinephrine	101-114	monoamine oxidase A	Homo sapiens	37-42
1962565-3	1991	Ascorbate is the cofactor for the dopamine beta-hydroxylase and peptidylglycine alpha-amidating monooxygenase systems, which catalyze the synthesis of norepinephrine and a variety of alpha-amidated peptides, respectively.	Norepinephrine	151-165	dopamine beta-hydroxylase	Homo sapiens	34-59
1837318-8	1991	The early elevation of pANP correlated with plasma concentrations of both noradrenaline (r = 0.55, n = 27, p less than 0.01) and creatine phosphokinase (r = 0.54, n = 27, p less than 0.01).	Norepinephrine	74-87	PILR alpha associated neural protein	Homo sapiens	23-27
1686742-0	1991	Norepinephrine neurons in mouse locus coeruleus express c-fos protein after N-methyl-D,L-aspartic acid (NMDA) treatment: relation to LH release.	Norepinephrine	0-14	FBJ osteosarcoma oncogene	Mus musculus	56-61
1922677-0	1991	Effects of active immunization against gonadotrophin-releasing hormone on the concentrations of noradrenaline, dopamine, 5-hydroxytryptamine and some of their metabolites in the brain and sexual organs of male rats.	Norepinephrine	96-109	gonadotropin releasing hormone 1	Rattus norvegicus	39-70
1788146-10	1991	In conclusion, receptors capable of interacting with NPY, presumably of the Y1 type, and VIP are present in the rabbit ovarian artery, and activation of these receptors may profoundly influence the response of the artery to norepinephrine.	Norepinephrine	224-238	neuropeptide Y	Oryctolagus cuniculus	53-56
1860614-7	1991	UCP gene expression is strongly controlled at the level of transcription by signals that are activated after the stimulation of brown adipocytes by norepinephrine.	Norepinephrine	148-162	uncoupling protein 1	Homo sapiens	0-3
1999028-2	1991	NPY coexists with noradrenaline in perivascular nerve terminals, may be released during sympathetic stimulation, and is a potent constrictor of the human coronary circulation and other vascular beds.	Norepinephrine	18-31	neuropeptide Y	Homo sapiens	0-3
1999028-3	1991	In vitro studies show that NPY can act either directly on vascular smooth muscle or indirectly by modulation of the presynaptic release or the postsynaptic actions of noradrenaline.	Norepinephrine	167-180	neuropeptide Y	Homo sapiens	27-30
1999028-5	1991	METHODS AND RESULTS: The effect on forearm blood flow of intra-arterial NPY was studied in six volunteers during coinfusion of noradrenaline and during reflex sympathetic stimulation induced by lower-body negative pressure.	Norepinephrine	127-140	neuropeptide Y	Homo sapiens	72-75
1880809-2	1991	Recently, NPY has also been reported to inhibit the relaxation to noradrenaline in isolated rabbit coronary arteries, but the composition of the Krebs solution described in this study indicated that it contained no magnesium.	Norepinephrine	66-79	neuropeptide Y	Oryctolagus cuniculus	10-13
1670626-3	1991	Neuropeptide Y (NPY), a 36-amino acid neuropeptide that is colocalized and released with norepinephrine from sympathetic nerves, has already been implicated in inflammatory reactions via modulation of histamine release from mast cells.	Norepinephrine	89-103	neuropeptide Y	Homo sapiens	0-14
1670626-3	1991	Neuropeptide Y (NPY), a 36-amino acid neuropeptide that is colocalized and released with norepinephrine from sympathetic nerves, has already been implicated in inflammatory reactions via modulation of histamine release from mast cells.	Norepinephrine	89-103	neuropeptide Y	Homo sapiens	16-19
1804579-9	1991	We then found that alpha 1-adrenoceptor agonism (phenylephrine or noradrenaline plus idazoxan) given intra-arterially stimulated VIP release (p less than 0.01).	Norepinephrine	66-79	vasoactive intestinal peptide	Sus scrofa	129-132
2147724-5	1990	Exogenous ANP given to dogs under constant norepinephrine infusion resulted in improvement of hemodynamic and renal parameters.	Norepinephrine	43-57	natriuretic peptide A	Canis lupus familiaris	10-13
2177121-4	1990	), a precursor of dopamine and noradrenaline, markedly potentiated the mono- (MSR) and polysynaptic reflexes (PSR).	Norepinephrine	31-44	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Rattus norvegicus	78-81
2171961-12	1990	These results suggest that noradrenaline acts on DDT1 MF-2 smooth muscle cells, represented by the formation of InsP3 and enhancement of internal Ca2+ originating from internal structures, via the alpha 1B-adrenoceptor subtype.	Norepinephrine	27-40	alpha-1B adrenergic receptor	Mesocricetus auratus	197-218
2385755-10	1990	These glucocorticoids stimulate phenylethanolamine-N-methyltransferase, which transforms norepinephrine to epinephrine.	Norepinephrine	89-103	phenylethanolamine-N-methyltransferase	Rattus norvegicus	32-70
1966520-5	1990	There was a 35%-55% increase in the release of arachidonate elicited by 10(-8) M EGF in the presence of 10(-4) M Bt2cAMP, noradrenaline, or isoproterenol.	Norepinephrine	122-135	epidermal growth factor	Homo sapiens	81-84
2346532-8	1990	The lack of increase in noradrenaline and adrenaline in the group of patients may be related to reduced activity of dopamine-beta-hydroxylase in patients with congestive heart failure NYHA class IV.	Norepinephrine	24-37	dopamine beta-hydroxylase	Homo sapiens	116-141
1970339-6	1990	The results demonstrate that neuropeptide Y is colocalized with noradrenaline in most of the human sympathetic neurons and that the nerve fibres may innervate selectively the noradrenergic and cholinergic subpopulations of ganglion cells depending on the transmitters of the nerves.	Norepinephrine	64-77	neuropeptide Y	Homo sapiens	29-43
1982606-7	1990	From these results we conclude: 1) norepinephrine infusion causes disparate responses in the coronary microvasculature: constriction occurs in vessels greater than 100 microns in diameter, but dilation, via autoregulatory escape, predominates in vessels less than 100 microns in diameter; 2) alpha 1-adrenergic receptors are located in coronary arterioles and arteries; and 3) alpha 2-adrenergic receptors are preferentially located in small coronary arterioles.	Norepinephrine	35-49	adrenoceptor alpha 1D	Homo sapiens	292-299
1983458-3	1990	The effects of noradrenaline microinjection (30 nmol in 1 microliter) into the LHA on urinary sodium excretion (UNaV) are blocked by previous injection of the alpha-1 antagonist prazosin (4 nmol in 1 microliter) from 3.22 +/- 0.25 to 0.59 +/- 0.04 microEq min-1 100 g body weight-1.	Norepinephrine	15-28	adrenoceptor alpha 1D	Homo sapiens	159-166
2328515-5	1990	Atrial adrenaline forming activity resembled adrenal phenylethanolamine-N-methyltransferase (PNMT) in its relatively high affinity for noradrenaline, substrate specificity for noradrenaline over dopamine, and inhibition by the PNMT inhibitor SKF 29661.	Norepinephrine	135-148	phenylethanolamine-N-methyltransferase	Rattus norvegicus	53-91
2328515-5	1990	Atrial adrenaline forming activity resembled adrenal phenylethanolamine-N-methyltransferase (PNMT) in its relatively high affinity for noradrenaline, substrate specificity for noradrenaline over dopamine, and inhibition by the PNMT inhibitor SKF 29661.	Norepinephrine	135-148	phenylethanolamine-N-methyltransferase	Rattus norvegicus	93-97
2328515-5	1990	Atrial adrenaline forming activity resembled adrenal phenylethanolamine-N-methyltransferase (PNMT) in its relatively high affinity for noradrenaline, substrate specificity for noradrenaline over dopamine, and inhibition by the PNMT inhibitor SKF 29661.	Norepinephrine	176-189	phenylethanolamine-N-methyltransferase	Rattus norvegicus	53-91
2328515-5	1990	Atrial adrenaline forming activity resembled adrenal phenylethanolamine-N-methyltransferase (PNMT) in its relatively high affinity for noradrenaline, substrate specificity for noradrenaline over dopamine, and inhibition by the PNMT inhibitor SKF 29661.	Norepinephrine	176-189	phenylethanolamine-N-methyltransferase	Rattus norvegicus	93-97
1966021-4	1990	It is assumed that either alpha-receptor density is affected or that signal transduction is altered, since electrophysiologically a persistent supersensitivity was found for the noradrenaline-evoked depression of glutamate-evoked firing in e.g. CA1 pyramidal cells of the hippocampus.	Norepinephrine	178-191	carbonic anhydrase 1	Rattus norvegicus	245-248
2250565-3	1990	MAO-A inhibition, as evidenced by up to 80% decreases in the plasma concentration of 3,4-dihydroxyphenylglycol, a deaminated metabolite of norepinephrine, was similar after both pretreatments.	Norepinephrine	139-153	monoamine oxidase A	Homo sapiens	0-5
33775645-2	2021	Most norepinephrine is taken up through the neuronal norepinephrine transporter (NET), which is implicated in cardiovascular diseases.	Norepinephrine	5-19	solute carrier family 6 member 2	Rattus norvegicus	53-79
33805843-8	2021	We found that A30P*A53T*alpha-Syn mice at 4-5 months of age showed 3.5-fold increases in human alpha-Syn expression in dopamine (DA) and norepinephrine (NE) neurons of the substantia nigra pars compacta (SNc) and locus coeruleus (LC), respectively, compared with mouse alpha-Syn levels.	Norepinephrine	137-151	synuclein alpha	Homo sapiens	24-33
33805843-8	2021	We found that A30P*A53T*alpha-Syn mice at 4-5 months of age showed 3.5-fold increases in human alpha-Syn expression in dopamine (DA) and norepinephrine (NE) neurons of the substantia nigra pars compacta (SNc) and locus coeruleus (LC), respectively, compared with mouse alpha-Syn levels.	Norepinephrine	137-151	synuclein, alpha	Mus musculus	95-104
33796867-4	2021	This olfactory circuit signals the gut to suppress DR-mediated longevity via octopamine, the mammalian homolog of norepinephrine, by regulating the energy sensor AMPK through a Gq-PLCbeta-CaMKK-dependent mechanism.	Norepinephrine	114-128	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	188-193
34767786-6	2021	Similarly, lowest energy conformations of noradrenaline and dopamine generated by docking into flexible beta2 AR models had binding free energies lower than those of best poses in rigid receptor models.	Norepinephrine	42-55	adenosine A2a receptor	Homo sapiens	104-112
34767786-7	2021	Furthermore, our findings show that L-DOPA and Droxidopa molecules have binding affinities comparable to those predicted for adrenaline, noradrenaline, and dopamine, which are consistent with previous experimental and computational findings and supported by the MD simulations of beta2AR-ligand complexes performed here.	Norepinephrine	137-150	adenosine A2a receptor	Homo sapiens	280-287
34867179-5	2021	Cerebellar surface perfusion of 25 muM noradrenaline induced decreases in the amplitude and area under the curve of N1 and N2, accompanied by an increase in the N2/N1 ratio.	Norepinephrine	39-52	notch 1	Mus musculus	116-125
34832862-2	2021	Histamine H3 receptor antagonists may represent an effective therapy as they have been shown to modulate histamine synthesis and release and affect a number of other neurotransmitters (norepinephrine, acetylcholine, gamma-aminobutyric acid, serotonin, substance P) thus influencing the food intake.	Norepinephrine	185-199	histamine receptor H3	Rattus norvegicus	0-21
34399896-8	2021	The method detection limits were 0.06, 0.16, 0.03 and 0.14 ng mL-1 for norepinephrine, epinephrine, dopamine and isoprenaline, respectively, and relative recoveries for these catecholamines were in the range of 98.56-108.1%, 92.56-110.0%, 98.79-112.3% and 88.14-97.81%, respectively.	Norepinephrine	71-85	L1 cell adhesion molecule	Mus musculus	62-66
34260097-2	2021	The well-known tryptophan64arginine polymorphism of the ADRB3 gene alters the response of the receptor to various stimuli, including adrenalin and noradrenalin, and may increase the susceptibility to develop overactive bladder (OAB).	Norepinephrine	147-159	adrenoceptor beta 3	Homo sapiens	56-61
34485365-6	2021	In white adipocytes, green tea compounds decreased both basal and norepinephrine-induced UCP1 mRNA levels, and this was associated with the suppression of cell differentiation, indicated by reduced lipogenic gene expression and lipid accumulation.	Norepinephrine	66-80	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	27-30
35045380-1	2022	Abnormally phosphorylated tau, an indicator of Alzheimer"s disease, accumulates in the first decades of life in the locus coeruleus (LC), the brain"s main noradrenaline supply.	Norepinephrine	155-168	microtubule associated protein tau	Homo sapiens	26-29
35210489-5	2022	Our ex vivo efflux experiments reveal that the NE transporter (NET) blocker desipramine elevates both norepinephrine (NE) and dopamine (DA), but not 5-HT levels, in PFC tissue slices from wild-type (WT) and DAT-KO, but not NET-KO mice.	Norepinephrine	102-116	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	Mus musculus	47-61
35167100-5	2022	Methods for characterization described here include norepinephrine-induced thermogenic gene expression using qPCR; norepinephrine-induced mitochondrial uncoupling using the Seahorse XFe96 Analyzer, and norepinephrine-induced expression of UCP1 using the RNAscope  Technology.	Norepinephrine	202-216	uncoupling protein 1	Homo sapiens	239-243
2532076-7	1989	After 2 weeks of pacing, ANP lowered norepinephrine release (by 16 +/- 6%) without affecting blood pressure or plasma renin activity, and vascular nonresponsiveness to ANP was verified under autonomic blockade.	Norepinephrine	37-51	natriuretic peptide A	Canis lupus familiaris	25-28
2532076-8	1989	These data indicate that, during the development of heart failure, an inhibitory action of ANP on norepinephrine release is unmasked by an ANP-specific vascular desensitization, whereas the inhibition of epinephrine release is observed throughout.	Norepinephrine	98-112	natriuretic peptide A	Canis lupus familiaris	91-94
2510587-4	1989	Patients with deficiency of dopamine-beta-hydroxylase had increased levels of dopa and dihydroxyphenylacetic acid and markedly decreased levels of norepinephrine and dihydroxyphenylglycol, suggesting compensatory increases in sympathetic nerve activity in the absence of norepinephrine biosynthesis.	Norepinephrine	147-161	dopamine beta-hydroxylase	Homo sapiens	28-53
2510587-4	1989	Patients with deficiency of dopamine-beta-hydroxylase had increased levels of dopa and dihydroxyphenylacetic acid and markedly decreased levels of norepinephrine and dihydroxyphenylglycol, suggesting compensatory increases in sympathetic nerve activity in the absence of norepinephrine biosynthesis.	Norepinephrine	271-285	dopamine beta-hydroxylase	Homo sapiens	28-53
2572175-4	1989	Several selective alpha 1- and alpha 2-adrenoceptor agonists and the endogenous mixed agonist, norepinephrine, all produced dose-related increases in pHi.	Norepinephrine	95-109	glucose-6-phosphate isomerase	Rattus norvegicus	150-153
2570793-2	1989	Norepinephrine (NE)-producing neurons are identified by immunocytochemistry of two NE biosynthetic enzymes, tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH), visualized by the peroxidase-antiperoxidase and immunogold-silver-staining methods.	Norepinephrine	0-14	dopamine beta-hydroxylase	Homo sapiens	138-163
2570793-2	1989	Norepinephrine (NE)-producing neurons are identified by immunocytochemistry of two NE biosynthetic enzymes, tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH), visualized by the peroxidase-antiperoxidase and immunogold-silver-staining methods.	Norepinephrine	0-14	dopamine beta-hydroxylase	Homo sapiens	165-168
2583236-3	1989	Conditions that increase the biophase concentration of norepinephrine, longer stimulation trains or application of yohimbine, decreased the potentiation by NPY, although in the presence of cocaine potentiation by NPY was unchanged.	Norepinephrine	55-69	neuropeptide Y	Oryctolagus cuniculus	156-159
2746226-10	1989	In conclusion, sympathetic nerves in the rat pineal gland contain tyrosine hydroxylase and dopamine beta-hydroxylase, the two enzymes required for the synthesis of noradrenaline.	Norepinephrine	164-177	dopamine beta-hydroxylase	Rattus norvegicus	91-116
2817346-1	1989	The monoamine oxidase A metabolite of noradrenaline, 3,4-dihydroxyphenylglycolaldehyde, is the precursor of 3,4-dihydroxymandelic acid, and 3,4-dihydroxyphenylglycol, metabolites of noradrenaline.	Norepinephrine	38-51	monoamine oxidase A	Homo sapiens	4-23
2817346-1	1989	The monoamine oxidase A metabolite of noradrenaline, 3,4-dihydroxyphenylglycolaldehyde, is the precursor of 3,4-dihydroxymandelic acid, and 3,4-dihydroxyphenylglycol, metabolites of noradrenaline.	Norepinephrine	182-195	monoamine oxidase A	Homo sapiens	4-23
2774765-4	1989	In aorta strips depleted of Ca2+ by several applications of noradrenaline (10(-6) M), Sr2+ induced a dose-response contraction in a Ca2+-free solution.	Norepinephrine	60-73	Stress response QTL 2	Rattus norvegicus	86-89
2702581-6	1989	This suggests a dopamine-norepinephrine pathway block, which supports previous reports of deficiency of dopamine beta-hydroxylase activity in some neuroblastomas.	Norepinephrine	25-39	dopamine beta-hydroxylase	Homo sapiens	104-129
2705532-1	1989	Neuropeptide Y (NPY) is a potent vasoconstrictor peptide contained in sympathetic nerve terminals and is co-released with norepinephrine.	Norepinephrine	122-136	neuropeptide Y	Homo sapiens	0-14
2705532-1	1989	Neuropeptide Y (NPY) is a potent vasoconstrictor peptide contained in sympathetic nerve terminals and is co-released with norepinephrine.	Norepinephrine	122-136	neuropeptide Y	Homo sapiens	16-19
2924733-10	1989	The effect of NPY was dose related and augmented by the addition of norepinephrine (10 nM).	Norepinephrine	68-82	neuropeptide Y	Homo sapiens	14-17
19210461-0	1989	Corticotrophin-Releasing Factor Antagonist [alpha helical CRF(9-41)] Blocks Central Noradrenaline-lnduced ACTH Secretion.	Norepinephrine	84-97	corticotropin releasing hormone	Homo sapiens	0-31
2538388-2	1989	In initial experiments, treatment with the centrally active phenylethanolomine N-methyltransferase (PNMT; the enzyme catalyzing methylation of norepinephrine to epinephrine) inhibitor SKF-64139 inhibited lordosis behavior induced by estradiol-17 beta benzoate plus progesterone.	Norepinephrine	143-157	phenylethanolamine N-methyltransferase	Cavia porcellus	60-98
2538388-2	1989	In initial experiments, treatment with the centrally active phenylethanolomine N-methyltransferase (PNMT; the enzyme catalyzing methylation of norepinephrine to epinephrine) inhibitor SKF-64139 inhibited lordosis behavior induced by estradiol-17 beta benzoate plus progesterone.	Norepinephrine	143-157	phenylethanolamine N-methyltransferase	Cavia porcellus	100-104
2481466-4	1989	DBH immunoreactive plexuses are found in all areas which conform in appearance to previous demonstrations of noradrenaline localization by fluorescence histochemistry.	Norepinephrine	109-122	dopamine beta-hydroxylase	Homo sapiens	0-3
2481466-8	1989	These observations indicate that NPY and GAL are distributed differently in LC neurons from noradrenaline and DBH.	Norepinephrine	92-105	neuropeptide Y	Homo sapiens	33-36
2563197-4	1989	Norepinephrine and acetylcholine increased immunoreactive corticotropin-releasing factor release into the culture medium in a dose-related manner.	Norepinephrine	0-14	corticotropin releasing hormone	Homo sapiens	58-88
2565245-0	1989	Evidence for the occurrence of an enkephalin-like peptide in adrenaline and noradrenaline neurons of the rat medulla oblongata.	Norepinephrine	76-89	proenkephalin	Rattus norvegicus	34-44
3241208-3	1988	The ability of neuropeptide Y to potentiate the constrictor response to noradrenaline in the ear artery was also dependent on the presence of an intact endothelium.	Norepinephrine	72-85	neuropeptide Y	Oryctolagus cuniculus	15-29
2844513-9	1988	The approximately equipotent effect of epinephrine and norepinephrine indicated that the beta-adrenergic effect on cAMP production is principally mediated via the beta 1-adrenergic receptor.	Norepinephrine	55-69	adrenoceptor beta 1	Bos taurus	163-189
2843407-6	1988	(-)-Norepinephrine, the unspecific beta-adrenergic agonist (-)-isoproterenol, and the beta 2-specific agonist terbutaline mimicked the effect of epinephrine on LDL-receptor activity.	Norepinephrine	0-18	low density lipoprotein receptor	Homo sapiens	160-172
3407677-8	1988	The vasoconstriction produced by noradrenaline was potentiated by subthreshold concentrations of NPY.	Norepinephrine	33-46	neuropeptide Y	Homo sapiens	97-100
2898856-0	1988	Blood levels, clearance rates and effects of epinephrine and norepinephrine on insulin and metabolites during alpha- and beta-adrenergic blockade in cattle in vivo, and in vitro degradation of dopamine in bovine blood.	Norepinephrine	61-75	insulin	Bos taurus	79-86
2898856-4	1988	alpha- and beta-adrenergic blockade markedly modified insulin, glucose and non-esterified fatty acid responses to epinephrine and norepinephrine.	Norepinephrine	130-144	insulin	Bos taurus	54-61
3285962-1	1988	The effect of age on norepinephrine (NE) stimulation of luteinizing hormone-releasing hormone (LH-RH) secretion from preoptic area-mediobasal hypothalamic (POA-MBH) explants was examined in the present study.	Norepinephrine	21-35	gonadotropin releasing hormone 1	Rattus norvegicus	56-93
2843779-1	1988	Norepinephrine (NE) has been shown to have a biphasic effect on evoked potentials in the CA1 region of the hippocampus of the rat in vitro, with a beta receptor mediating an increase and an alpha receptor eliciting a decrease in the amplitude of the population spike.	Norepinephrine	0-14	carbonic anhydrase 1	Rattus norvegicus	89-92
2834003-1	1988	Prostaglandin E2 (PGE2) has been implicated as a mediator of norepinephrine-induced luteinizing hormone-releasing hormone (LHRH) release from the hypothalamus.	Norepinephrine	61-75	gonadotropin releasing hormone 1	Rattus norvegicus	84-121
2834003-1	1988	Prostaglandin E2 (PGE2) has been implicated as a mediator of norepinephrine-induced luteinizing hormone-releasing hormone (LHRH) release from the hypothalamus.	Norepinephrine	61-75	gonadotropin releasing hormone 1	Rattus norvegicus	123-127
2848631-2	1988	NPY has been localized in neurons that synthesize norepinephrine or epinephrine and also in many cell bodies which are not catecholaminergic.	Norepinephrine	50-64	neuropeptide Y	Homo sapiens	0-3
3345900-0	1988	Leucine-enkephalin- and neuropeptide Y-modulation of [3H]noradrenaline release in the oviduct of mature and juvenile rabbits.	Norepinephrine	57-70	neuropeptide Y	Oryctolagus cuniculus	24-38
3345900-2	1988	The effects of leucine-enkephalin and neuropeptide Y (NPY) on [3H]noradrenaline release induced by electrical field stimulation were studied in the isthmic part of the oviduct of juvenile and mature rabbits.	Norepinephrine	66-79	neuropeptide Y	Oryctolagus cuniculus	54-57
20501291-3	1988	The role of this glutamate receptor site was investigated by studying the effects of select glutamate receptor agonists and antagonists and of ?-aminobutyric acid on the basal- and on the norepinephrine-stimulated activity of arylalkylamine N-acetyltransferase in rat pineal glands that were incubated in Dulbecco"s Modified Eagle Medium at 37 degrees C for 20 min in an atmosphere of 5% CO(2)/95% O(2).	Norepinephrine	188-202	aralkylamine N-acetyltransferase	Rattus norvegicus	226-260
3233105-2	1988	Because dopamine-beta-hydroxylase, an essential enzyme in norepinephrine biosynthesis, is copper-dependent, we studied norepinephrine metabolism in vivo in 5 affected children.	Norepinephrine	58-72	dopamine beta-hydroxylase	Homo sapiens	8-33
3233105-2	1988	Because dopamine-beta-hydroxylase, an essential enzyme in norepinephrine biosynthesis, is copper-dependent, we studied norepinephrine metabolism in vivo in 5 affected children.	Norepinephrine	119-133	dopamine beta-hydroxylase	Homo sapiens	8-33
3691657-3	1987	Turnover in the left ventricles, as estimated by the decrease of noradrenaline under dopamine beta-hydroxylase inhibition with bis-(4-methyl-1-homo-piperazinyl-thiocarbonyl)-disulfide (FLA-63), was unaffected by ligation whether in untreated, adrenalectomized, or hexamethonium-treated rats.	Norepinephrine	65-78	dopamine beta-hydroxylase	Rattus norvegicus	85-110
2894798-1	1987	Ornithine decarboxylase activity of rat lung was induced by s.c. injection of acetylcholine, norepinephrine, epinephrine, dopamine, serotonin, vasopressin, angiotensin II, and adrenocorticotropic hormone, but not by gonadotropin, aldosterone, corticosterone or hydrocortisone.	Norepinephrine	93-107	ornithine decarboxylase 1	Rattus norvegicus	0-23
3441159-2	1987	The mean CSF concentrations of noradrenaline and dopamine were found to be 123 +/- 48 pg/ml and 10 +/- 6 pg/ml, respectively, in 14 drug-free subjects.	Norepinephrine	31-44	colony stimulating factor 2	Homo sapiens	9-12
3441159-5	1987	As a preliminary investigation, signs of seasonal variation in the CSF concentration of noradrenaline and dopamine were registered in 4 female subjects.	Norepinephrine	88-101	colony stimulating factor 2	Homo sapiens	67-70
3662525-1	1987	The copper-containing monooxygenase dopamine beta-hydroxylase catalyzes the hydroxylation of dopamine at the benzylic position to form norepinephrine.	Norepinephrine	135-149	dopamine beta-hydroxylase	Homo sapiens	36-61
2821226-0	1987	Norepinephrine regulation of alpha-1 receptors and alpha-1-stimulated phosphoinositide hydrolysis in primary neuronal cultures.	Norepinephrine	0-14	adrenoceptor alpha 1D	Homo sapiens	29-36
2821226-1	1987	Alpha-1 receptor density and alpha-1 receptor-stimulated phosphoinositide hydrolysis in neuronal primary cultures are regulated by exposure of the cells to the alpha-1 agonist norepinephrine (NE).	Norepinephrine	176-190	adrenoceptor alpha 1D	Homo sapiens	0-7
2821226-1	1987	Alpha-1 receptor density and alpha-1 receptor-stimulated phosphoinositide hydrolysis in neuronal primary cultures are regulated by exposure of the cells to the alpha-1 agonist norepinephrine (NE).	Norepinephrine	176-190	adrenoceptor alpha 1D	Homo sapiens	29-36
2821226-1	1987	Alpha-1 receptor density and alpha-1 receptor-stimulated phosphoinositide hydrolysis in neuronal primary cultures are regulated by exposure of the cells to the alpha-1 agonist norepinephrine (NE).	Norepinephrine	176-190	adrenoceptor alpha 1D	Homo sapiens	160-167
2883548-2	1987	The theory suggests that final effects on alpha-1 mediated neurotransmission may be produced not only by drugs which have direct effects on the alpha-1 receptor or its second messenger, but also by drugs having effects on neurotransmitter systems such as acetylcholine, GABA, and serotonin, among others, which modulate the activity of central norepinephrine neurons or, via feedback mechanisms, by drugs having effects on adrenergic receptors other than the alpha-1 receptor itself.	Norepinephrine	344-358	adrenoceptor alpha 1D	Homo sapiens	42-49
2883548-2	1987	The theory suggests that final effects on alpha-1 mediated neurotransmission may be produced not only by drugs which have direct effects on the alpha-1 receptor or its second messenger, but also by drugs having effects on neurotransmitter systems such as acetylcholine, GABA, and serotonin, among others, which modulate the activity of central norepinephrine neurons or, via feedback mechanisms, by drugs having effects on adrenergic receptors other than the alpha-1 receptor itself.	Norepinephrine	344-358	adrenoceptor alpha 1D	Homo sapiens	144-151
2883548-2	1987	The theory suggests that final effects on alpha-1 mediated neurotransmission may be produced not only by drugs which have direct effects on the alpha-1 receptor or its second messenger, but also by drugs having effects on neurotransmitter systems such as acetylcholine, GABA, and serotonin, among others, which modulate the activity of central norepinephrine neurons or, via feedback mechanisms, by drugs having effects on adrenergic receptors other than the alpha-1 receptor itself.	Norepinephrine	344-358	adrenoceptor alpha 1D	Homo sapiens	144-151
2953252-6	1987	In heart-failure dogs, infusion of atrial natriuretic peptide increased plasma concentrations of norepinephrine and epinephrine.	Norepinephrine	97-111	natriuretic peptide A	Canis lupus familiaris	35-61
3033703-2	1987	The secretion of luteinizing hormone-releasing hormone (LHRH) under basal conditions, and in the presence of norepinephrine (NE; 60 microM), was significantly enhanced in median eminence fragments obtained 1 hr post-treatment with THC (50 mg/kg), while addition of THC (250 ng/ml) to the incubation media enhanced clonidine, as well as NE-stimulated LHRH release, but did not affect basal LHRH release.	Norepinephrine	109-123	gonadotropin releasing hormone 1	Mus musculus	17-54
3033703-2	1987	The secretion of luteinizing hormone-releasing hormone (LHRH) under basal conditions, and in the presence of norepinephrine (NE; 60 microM), was significantly enhanced in median eminence fragments obtained 1 hr post-treatment with THC (50 mg/kg), while addition of THC (250 ng/ml) to the incubation media enhanced clonidine, as well as NE-stimulated LHRH release, but did not affect basal LHRH release.	Norepinephrine	109-123	gonadotropin releasing hormone 1	Mus musculus	56-60
3495811-2	1987	Among 21 depressed patients cerebrospinal fluid (CSF) levels of CRH significantly correlated with urinary outputs of norepinephrine and its major metabolites, and there were trends for significant correlations with both CSF and plasma levels of norepinephrine.	Norepinephrine	117-131	corticotropin releasing hormone	Homo sapiens	64-67
3495811-2	1987	Among 21 depressed patients cerebrospinal fluid (CSF) levels of CRH significantly correlated with urinary outputs of norepinephrine and its major metabolites, and there were trends for significant correlations with both CSF and plasma levels of norepinephrine.	Norepinephrine	245-259	corticotropin releasing hormone	Homo sapiens	64-67
3495811-3	1987	These results suggest that CRH may be associated with the dysregulation of the norepinephrine system that is found in desperation.	Norepinephrine	79-93	corticotropin releasing hormone	Homo sapiens	27-30
2437709-1	1987	In previous reports of studies of patients with alcoholic Korsakoff"s psychosis, data were presented showing significant correlations between neuropsychometric measures of amnesia and the CSF levels of the major brain metabolite of norepinephrine (NE), which was consistently reduced among a large group of experimental subjects.	Norepinephrine	232-246	colony stimulating factor 2	Homo sapiens	188-191
3106991-2	1987	L-threo-DOPS in combination with nialamide markedly increased both the locomotor activity and the concentrations of the brain, heart and kidney norepinephrine (NE) in the FLA-63-treated mice.	Norepinephrine	144-158	4-hydroxyphenylpyruvic acid dioxygenase	Mus musculus	171-174
3796219-1	1987	Dopamine-beta-hydroxylase catalyzes the beta-oxidation of dopamine to noradrenaline while phenylethanolamine-N-methyltransferase converts noradrenaline to adrenaline.	Norepinephrine	70-83	dopamine beta-hydroxylase	Homo sapiens	0-25
3796219-1	1987	Dopamine-beta-hydroxylase catalyzes the beta-oxidation of dopamine to noradrenaline while phenylethanolamine-N-methyltransferase converts noradrenaline to adrenaline.	Norepinephrine	138-151	dopamine beta-hydroxylase	Homo sapiens	0-25
2884200-8	1987	In addition to vascular noradrenaline-containing fibers as described earlier the study shows parenchymal DBH-immunoreactive fibers in the neural lobe, suggesting a local role for noradrenaline in this lobe.	Norepinephrine	179-192	dopamine beta-hydroxylase	Rattus norvegicus	105-108
2455171-1	1987	Neuropeptide Y (NPY) is a cotransmitter with noradrenaline in perivascular sympathetic nerves.	Norepinephrine	45-58	neuropeptide Y	Oryctolagus cuniculus	0-14
2455171-1	1987	Neuropeptide Y (NPY) is a cotransmitter with noradrenaline in perivascular sympathetic nerves.	Norepinephrine	45-58	neuropeptide Y	Oryctolagus cuniculus	16-19
2455181-6	1987	Cardiac tissues were weighed and subsequently analyzed for activities of tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH), two enzymes catalyzing the biosynthesis of catecholamines (CAs), and of choline acetyltransferase (CAT), a marker of parasympathetic activity, as well as for norepinephrine (NE).	Norepinephrine	294-308	tyrosine 3-monooxygenase	Cavia porcellus	73-93
2878972-7	1987	In addition, the abundance of adrenaline in this area at early gestational stages strongly suggests that, despite the paucity of tyrosine hydroxylase, phenylethanolamine N-methyltransferase is active in vivo and is utilizing a substrate other than noradrenaline.	Norepinephrine	248-261	phenylethanolamine-N-methyltransferase	Rattus norvegicus	151-189
3295118-1	1987	"Metabolizing systems" are responsible for the quick inactivation of noradrenaline released from adrenergic nerve endings: a transport mechanism (uptake1 or uptake2) is arranged in series with the intracellular enzyme (monoamine oxidase, MAO; catechol-O-methyltransferase, COMT).	Norepinephrine	69-82	catechol-O-methyltransferase	Rattus norvegicus	243-271
3295118-1	1987	"Metabolizing systems" are responsible for the quick inactivation of noradrenaline released from adrenergic nerve endings: a transport mechanism (uptake1 or uptake2) is arranged in series with the intracellular enzyme (monoamine oxidase, MAO; catechol-O-methyltransferase, COMT).	Norepinephrine	69-82	catechol-O-methyltransferase	Rattus norvegicus	273-277
3480939-2	1987	However, availability of other selective MAO-B inhibitors have clearly shown that this is not the case, since the "cheese effect" is associated with the selective inhibition of MAO-A, the enzyme responsible for intraneuronal oxidation of noradrenaline.	Norepinephrine	238-251	monoamine oxidase A	Homo sapiens	177-182
3480939-3	1987	Following inhibition of neuronal MAO-A, noradrenaline in the cytoplasmic intraneuronal pool can increase to high levels.	Norepinephrine	40-53	monoamine oxidase A	Homo sapiens	33-38
33352230-9	2021	Knockdown of Piezo2 in NG also attenuated the baroreflex and increased serum norepinephrine (NE) concentration in WKY rats.	Norepinephrine	77-91	piezo-type mechanosensitive ion channel component 2	Rattus norvegicus	13-19
31812551-4	2020	We found that Mdga1-KO mice exhibited statistically significant impairment of PPI, and had higher levels of homovanillic acid (HVA) in all three brain regions studied compared with Mdga1-HT and WT mice (P &lt; 0.05), while levels of norepinephrine, DA and its metabolites 3,4-dihydroxyphenylacetic acid and 3-methoxytyramine remained unchanged.	Norepinephrine	233-247	MAM domain containing glycosylphosphatidylinositol anchor 1	Mus musculus	14-19
31771069-3	2020	Catechol-O-methyltransferase (COMT) and monoamine oxidase B (MAOB) are the enzymes that regulate degradation of dopamine, while dopamine beta-hydroxylase (DBH) is involved in synthesis of noradrenaline.	Norepinephrine	188-201	monoamine oxidase B	Homo sapiens	40-59
31771069-3	2020	Catechol-O-methyltransferase (COMT) and monoamine oxidase B (MAOB) are the enzymes that regulate degradation of dopamine, while dopamine beta-hydroxylase (DBH) is involved in synthesis of noradrenaline.	Norepinephrine	188-201	monoamine oxidase B	Homo sapiens	61-65
31356684-2	2019	The nuclear translocation of nuclear factor kappa-B (NFkappaB) homodimers, lacking transactivation domains, once induced by lipopolysaccharide (LPS) or tumor necrosis factor (TNF), inhibits the expression of Aanat gene and the synthesis of noradrenaline (NA)-induced melatonin.	Norepinephrine	240-253	aralkylamine N-acetyltransferase	Homo sapiens	208-213
30943999-5	2019	It was proposed that norepinephrine is released from Merkel cells upon mechanical stimulation to subsequently activate beta2 adrenergic receptors on Merkel disc nerve endings leading to nerve impulses.	Norepinephrine	21-35	hemoglobin, beta adult minor chain	Mus musculus	119-124
30651375-1	2019	Beta-adrenergic receptor (beta-AR) activation by norepinephrine (NE) enhances memory and stabilizes long-term potentiation (LTP), a form of synaptic plasticity believed to underlie some forms of hippocampal memory.	Norepinephrine	49-63	adrenergic receptor, beta 1	Mus musculus	0-24
30651375-1	2019	Beta-adrenergic receptor (beta-AR) activation by norepinephrine (NE) enhances memory and stabilizes long-term potentiation (LTP), a form of synaptic plasticity believed to underlie some forms of hippocampal memory.	Norepinephrine	49-63	adrenergic receptor, beta 1	Mus musculus	26-33
30571558-0	2019	Norepinephrine-Induced Stimulation of Kir4.1/Kir5.1 Is Required for the Activation of NaCl Transporter in Distal Convoluted Tubule.	Norepinephrine	0-14	potassium inwardly-rectifying channel, subfamily J, member 16	Mus musculus	45-51
30341278-8	2018	Fine-tuning of noradrenaline homeostasis by a MIR579 genetic variation modulated central and peripheral sympathetic noradrenergic activation during fear processing and anxiety.	Norepinephrine	15-28	microRNA 579	Homo sapiens	46-52
30007012-1	2018	BACKGROUND AND PURPOSE: We have demonstrated that i.c.v.-administered (+-)-epibatidine, a nicotinic ACh receptor (nAChR) agonist, induced secretion of noradrenaline and adrenaline (catecholamines) from the rat adrenal medulla with dihydro-beta-erythroidin (an alpha4beta2 nAChR antagonist)-sensitive brain mechanisms.	Norepinephrine	151-164	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	90-112
30007012-1	2018	BACKGROUND AND PURPOSE: We have demonstrated that i.c.v.-administered (+-)-epibatidine, a nicotinic ACh receptor (nAChR) agonist, induced secretion of noradrenaline and adrenaline (catecholamines) from the rat adrenal medulla with dihydro-beta-erythroidin (an alpha4beta2 nAChR antagonist)-sensitive brain mechanisms.	Norepinephrine	151-164	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	114-119
30007012-1	2018	BACKGROUND AND PURPOSE: We have demonstrated that i.c.v.-administered (+-)-epibatidine, a nicotinic ACh receptor (nAChR) agonist, induced secretion of noradrenaline and adrenaline (catecholamines) from the rat adrenal medulla with dihydro-beta-erythroidin (an alpha4beta2 nAChR antagonist)-sensitive brain mechanisms.	Norepinephrine	151-164	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	272-277
29478130-9	2018	Additionally, other neuroprotective actions of noradrenaline, such as the production of brain derived neurotrophic factor and the inhibition of the inducible nitric oxide synthase in astrocytes were modified by CCL2.	Norepinephrine	47-60	brain-derived neurotrophic factor	Rattus norvegicus	88-121
29851347-6	2018	Here, we briefly discuss the effects of catecholamine receptor modulators on synaptic plasticity in the BNST due to the role of norepinephrine in LTD and dopamine on the short-term component of LTP as well as the role that signaling at these receptors plays in reinstatement of drug- and alcohol-seeking behaviors.	Norepinephrine	128-142	adrenoceptor beta 2	Homo sapiens	40-62
29377263-0	2018	The alpha1-adrenergic receptor is involved in hepcidin upregulation induced by adrenaline and norepinephrine via the STAT3 pathway.	Norepinephrine	94-108	hepcidin antimicrobial peptide	Mus musculus	46-54
29658580-0	2018	Norepinephrine inhibits the cytotoxicity of NK92-MI cells via the beta2-adrenoceptor/cAMP/PKA/p-CREB signaling pathway.	Norepinephrine	0-14	adrenoceptor beta 2	Homo sapiens	66-84
29658580-0	2018	Norepinephrine inhibits the cytotoxicity of NK92-MI cells via the beta2-adrenoceptor/cAMP/PKA/p-CREB signaling pathway.	Norepinephrine	0-14	cAMP responsive element binding protein 1	Homo sapiens	96-100
29720569-2	2018	We tested whether phosphodiesterase 2A (PDE2A), which regulates the action of BNP-activated cyclic guanosine monophosphate (cGMP), was directly involved in modulating Ca2+ handling from stellate ganglia (SG) neurons and cardiac norepinephrine (NE) release in rats and humans with an enhanced sympathetic phenotype.	Norepinephrine	228-242	phosphodiesterase 2A	Rattus norvegicus	18-38
29720569-2	2018	We tested whether phosphodiesterase 2A (PDE2A), which regulates the action of BNP-activated cyclic guanosine monophosphate (cGMP), was directly involved in modulating Ca2+ handling from stellate ganglia (SG) neurons and cardiac norepinephrine (NE) release in rats and humans with an enhanced sympathetic phenotype.	Norepinephrine	228-242	phosphodiesterase 2A	Rattus norvegicus	40-45
29524394-2	2018	The current study aimed to clarify the effects of single nucleotide polymorphisms (SNPs) of human SULT1A3 and SULT1A4 genes on the enzymatic characteristics of the sulfation of dopamine, epinephrine, norepinephrine and serotonin by SULT1A3 allozymes.	Norepinephrine	200-214	sulfotransferase family 1A member 3	Homo sapiens	98-105
29888233-4	2018	Fez1-knockout (KO) mice show reduced expression of tyrosine hydroxylase in the midbrain and the brain stem and have reduced levels of dopamine, norepinephrine, or their metabolites in both the nucleus accumbens and the prefrontal cortex.	Norepinephrine	144-158	fasciculation and elongation protein zeta 1 (zygin I)	Mus musculus	0-4
29552556-1	2018	Monoamine oxidase B (MAO-B) catalyzes deamination of monoamines such as neurotransmitters dopamine and norepinephrine.	Norepinephrine	103-117	monoamine oxidase B	Homo sapiens	0-19
29552556-1	2018	Monoamine oxidase B (MAO-B) catalyzes deamination of monoamines such as neurotransmitters dopamine and norepinephrine.	Norepinephrine	103-117	monoamine oxidase B	Homo sapiens	21-26
33371319-2	2020	The histamine 3 receptor (H3R) is known to be cardioprotective during acute ischemia by acting to limit norepinephrine release.	Norepinephrine	104-118	histamine receptor H3	Mus musculus	4-24
33371319-2	2020	The histamine 3 receptor (H3R) is known to be cardioprotective during acute ischemia by acting to limit norepinephrine release.	Norepinephrine	104-118	histamine receptor H3	Mus musculus	26-29
33165197-8	2020	Our results suggest that norepinephrine activation of beta-adrenoceptors in the hippocampal dentate gyrus is involved in spatial learning and memory enhancement induced by CRS in aged rats, in part via modulations of synaptic efficiency and CREB-BDNF signaling pathway.	Norepinephrine	25-39	cAMP responsive element binding protein 1	Rattus norvegicus	241-245
33110450-5	2020	Results: Peroxisome proliferator activated receptor gamma- coactivator-1 alpha (PGC-1 alpha) and uncoupling protein 1 gene expression increased significantly in the normal weight group, but not in the overweight group, with norepinephrine treatment.	Norepinephrine	224-238	uncoupling protein 1	Homo sapiens	97-117
33178600-8	2020	We demonstrated that knockdown of CD147 inhibited glioma invasiveness and metastasis with norepinephrine stimulation.	Norepinephrine	90-104	basigin (Ok blood group)	Homo sapiens	34-39
33178600-9	2020	Luciferase reporter gene experiments further demonstrated that the expression of CD147 is up-regulated primarily by norepinephrine via the beta-Adrenalin receptor (betaAR)-beta-arrestin1-ERK1/2-Sp1 pathway.	Norepinephrine	116-130	basigin (Ok blood group)	Homo sapiens	81-86
32801034-8	2020	Furthermore, there was a significant reduction (p <= 0.05) in the effect of norepinephrine on cell migration when the beta2-AR was inhibited by propranolol.	Norepinephrine	76-90	adenosine A2a receptor	Homo sapiens	118-126
32275785-0	2020	Norepinephrine stabilizes translation-dependent, homosynaptic long-term potentiation through mechanisms requiring the cAMP sensor Epac, mTOR and MAPK.	Norepinephrine	0-14	mechanistic target of rapamycin kinase	Mus musculus	136-140
32275785-7	2020	Norepinephrine mediated enhancement of LTP was reduced by inhibition of mTOR and Epac but not PKA, suggesting that the endogenous beta-AR ligand norepinephrine may preferentially recruit Epac signaling to promote enduring changes in synaptic strength.	Norepinephrine	0-14	mechanistic target of rapamycin kinase	Mus musculus	72-76
32275785-7	2020	Norepinephrine mediated enhancement of LTP was reduced by inhibition of mTOR and Epac but not PKA, suggesting that the endogenous beta-AR ligand norepinephrine may preferentially recruit Epac signaling to promote enduring changes in synaptic strength.	Norepinephrine	145-159	mechanistic target of rapamycin kinase	Mus musculus	72-76
32595040-3	2020	Norepinephrine, a sympathetic nervous system neurotransmitter mediating cold-induced BAT activation, altered the composition of brown adipocyte (BAC)-derived exosomal miRNAs; among them, miR-132-3p was significantly induced.	Norepinephrine	0-14	microRNA 1323	Homo sapiens	187-197
32697958-4	2020	In vitro studies show that OCTs/PMAT are also capable of norepinephrine transport, raising the possibility that decynium-22 might enhance the antidepressant-like effects of norepinephrine transporter inhibitors.	Norepinephrine	57-71	solute carrier family 29 member 4	Homo sapiens	32-36
32697958-4	2020	In vitro studies show that OCTs/PMAT are also capable of norepinephrine transport, raising the possibility that decynium-22 might enhance the antidepressant-like effects of norepinephrine transporter inhibitors.	Norepinephrine	173-187	solute carrier family 29 member 4	Homo sapiens	32-36
32544503-2	2020	Deactivation of extra-neuronal norepinephrine is mediated by catechol-O-methyltransferase (COMT).	Norepinephrine	31-45	catechol-O-methyltransferase	Rattus norvegicus	61-89
32544503-2	2020	Deactivation of extra-neuronal norepinephrine is mediated by catechol-O-methyltransferase (COMT).	Norepinephrine	31-45	catechol-O-methyltransferase	Rattus norvegicus	91-95
32772437-2	2020	Here, we report that a single injection of norepinephrine (NE; 1 mg kg-1 ; s.c) attenuated the fasting-induced up-regulation of FoxO-target genes in tibialis anterior (TA) muscles by the stimulation of PKA/CREB and Akt/FoxO1 signaling pathways.	Norepinephrine	43-57	forkhead box O1	Mus musculus	219-224
32623336-4	2020	We demonstrated that YAP1 was dephosphorylated and translocated from the cytoplasm to the nucleus by norepinephrine, a process initiated by ADRB2/cAMP/protein kinase A activation.	Norepinephrine	101-115	adrenergic receptor, beta 2	Mus musculus	140-145
32332112-7	2020	These effects may result from coordinated regulation of bladder afferent activity via M3 muscarinic inhibition and beta3 adrenoreceptor activation by norepinephrine elevation due to norepinephrine transporter inhibition.	Norepinephrine	150-164	solute carrier family 6 member 2	Rattus norvegicus	182-208
32045472-3	2020	We demonstrate here a role for the beta2-adrenergic receptor (beta2-AR), which binds the stress mediators adrenaline and noradrenaline, in modulating host response to mouse cytomegalovirus (MCMV) infection.	Norepinephrine	121-134	adrenergic receptor, beta 2	Mus musculus	35-60
32148128-5	2020	This protective pathway involves activation of PVN Galphai2 signaling pathways, which mediate sympathoinhibition to the blood vessels and kidneys (renal norepinephrine [pg/mg] 8% NaCl; SCR oligodeoxynucleotide 375+-39 versus Galphai2 oligodeoxynucleotide 850+-27; P<0.05) and suppression of the activity of the sodium chloride cotransporter assessed as peak natriuresis to hydrochlorothiazide.	Norepinephrine	153-167	G protein subunit alpha i2	Rattus norvegicus	51-59
31721030-5	2020	Preadipocytes that were treated with polychlorinated biphenyl congener 126 (PCB126), followed by differentiation, were suppressed for their ability to activate UCP1 upon beta-adrenergic stimulation with norepinephrine (NE), demonstrating a block in the beiging response.	Norepinephrine	203-217	uncoupling protein 1	Homo sapiens	160-164
31811856-3	2020	Noradrenaline increased alpha1B-adrenergic receptor-Rab5 interaction, which was blocked by paroxetine and by expression of the dominant-negative GRK2 mutant.	Norepinephrine	0-13	RAB5A, member RAS oncogene family	Homo sapiens	52-56
31707103-5	2020	These results raise the possibility that inflammation-mediated beta2-adrenoceptor downregulation in glia may dampen the innate anti-inflammatory properties of noradrenaline in the CNS.	Norepinephrine	159-172	adrenoceptor beta 2	Rattus norvegicus	63-81
31822578-0	2020	Congenital absence of norepinephrine due to CYB561 mutations.	Norepinephrine	22-36	cytochrome b561	Homo sapiens	44-50
31822578-1	2020	OBJECTIVE: Cytochrome b561 (CYB561) generates ascorbic acid, a cofactor in the enzymatic conversion of dopamine to norepinephrine by dopamine beta-hydroxylase.	Norepinephrine	115-129	cytochrome b561	Homo sapiens	11-26
31822578-1	2020	OBJECTIVE: Cytochrome b561 (CYB561) generates ascorbic acid, a cofactor in the enzymatic conversion of dopamine to norepinephrine by dopamine beta-hydroxylase.	Norepinephrine	115-129	cytochrome b561	Homo sapiens	28-34
31822578-1	2020	OBJECTIVE: Cytochrome b561 (CYB561) generates ascorbic acid, a cofactor in the enzymatic conversion of dopamine to norepinephrine by dopamine beta-hydroxylase.	Norepinephrine	115-129	dopamine beta-hydroxylase	Homo sapiens	133-158
32342809-3	2020	MAO-A is a flavoenzyme, which binds to the outer mitochondrial membrane and catalyzes the oxidative transformations of neurotransmitters like serotonin, norepinephrine, and dopamine.	Norepinephrine	153-167	monoamine oxidase A	Homo sapiens	0-5
31799519-0	2019	Critical nucleus of Greek-key-like core of alpha-synuclein protofibril and its disruption by dopamine and norepinephrine.	Norepinephrine	106-120	synuclein alpha	Homo sapiens	43-58
31631436-14	2019	Minocycline co-infusion significantly attenuated the increase in MAP and abolished the increase in plasma noradrenaline and inflammation in Galphai2 ODN-infused animals on HS.	Norepinephrine	106-119	G protein subunit alpha i2	Rattus norvegicus	140-148
31183808-5	2019	Only norepinephrine seemed to also modulate subliminal conflict processing, as evidenced by better performance of the DBH rs1611122 CC genotype in case of high subliminal conflict load.	Norepinephrine	5-19	dopamine beta-hydroxylase	Homo sapiens	118-121
31445965-6	2019	Site selective stimulation of the SMG induced the release of norepinephrine, resulting in beta2AR dependent acetylcholine release in the MLN and spleen.	Norepinephrine	61-75	adenosine A2a receptor	Homo sapiens	90-97
31527337-6	2019	Norepinephrine further increased VEGF mRNA; this effect was unaffected by carvedilol.	Norepinephrine	0-14	vascular endothelial growth factor A	Rattus norvegicus	33-37
31631645-1	2019	The aim of present work is to assess the effects of bradykinin (Br) or noradrenaline (Nor) preconditioning to the levels of antioxidant enzymes: superoxide dismutase (SOD), copper, zinc superoxide dismutase (CuZn-SOD), manganese superoxide dismutase (Mn-SOD) and catalase in ischemia/reperfusion (I/R) model in the rabbit spinal cord white matter as well as effect on glial fibrillary acidic protein (GFAP) and ubiquitin immunoreaction in glial cells.	Norepinephrine	71-84	SOD-2	Oryctolagus cuniculus	219-249
31631645-1	2019	The aim of present work is to assess the effects of bradykinin (Br) or noradrenaline (Nor) preconditioning to the levels of antioxidant enzymes: superoxide dismutase (SOD), copper, zinc superoxide dismutase (CuZn-SOD), manganese superoxide dismutase (Mn-SOD) and catalase in ischemia/reperfusion (I/R) model in the rabbit spinal cord white matter as well as effect on glial fibrillary acidic protein (GFAP) and ubiquitin immunoreaction in glial cells.	Norepinephrine	71-84	SOD-2	Oryctolagus cuniculus	251-257
31631645-1	2019	The aim of present work is to assess the effects of bradykinin (Br) or noradrenaline (Nor) preconditioning to the levels of antioxidant enzymes: superoxide dismutase (SOD), copper, zinc superoxide dismutase (CuZn-SOD), manganese superoxide dismutase (Mn-SOD) and catalase in ischemia/reperfusion (I/R) model in the rabbit spinal cord white matter as well as effect on glial fibrillary acidic protein (GFAP) and ubiquitin immunoreaction in glial cells.	Norepinephrine	86-89	SOD-2	Oryctolagus cuniculus	219-249
31631645-1	2019	The aim of present work is to assess the effects of bradykinin (Br) or noradrenaline (Nor) preconditioning to the levels of antioxidant enzymes: superoxide dismutase (SOD), copper, zinc superoxide dismutase (CuZn-SOD), manganese superoxide dismutase (Mn-SOD) and catalase in ischemia/reperfusion (I/R) model in the rabbit spinal cord white matter as well as effect on glial fibrillary acidic protein (GFAP) and ubiquitin immunoreaction in glial cells.	Norepinephrine	86-89	SOD-2	Oryctolagus cuniculus	251-257
31279527-7	2019	The down-regulation of NT5DC2 by siRNA increased the synthesis of catecholamines (dopamine, noradrenaline, and adrenaline) in PC12D cells.	Norepinephrine	92-105	5'-nucleotidase domain containing 2	Rattus norvegicus	23-29
31484392-6	2019	In contrast, facilitation of spontaneous IPSCs (sIPSCs) by norepinephrine (NE) was significantly reduced in BDNF+/- mice.	Norepinephrine	59-73	brain derived neurotrophic factor	Mus musculus	108-112
31433293-5	2019	This pathway is accessed by the physiological neurotransmitter norepinephrine (NE) via an Oct3 organic cation transporter.	Norepinephrine	63-77	solute carrier family 22 member 8	Rattus norvegicus	90-94
30882962-3	2019	The present review has summarized the currently available pre-clinical and clinical data on the interactions of CB1 and cannabinoid type-2 receptors (CB2 ) with the central neurotransmitters; dopamine, serotonin, noradrenaline, GABA, glutamate and opioids.	Norepinephrine	213-226	cannabinoid receptor 2	Homo sapiens	150-153
31700615-9	2019	Noradrenaline concentrations were increased after stroke in both placebo and IL-1Ra-treated stroke patients compared to non-stroke controls.	Norepinephrine	0-13	interleukin 1 receptor antagonist	Homo sapiens	77-83
31144035-7	2019	We found reduced secretagogin expression in locus coeruleus from subjects with Alzheimer"s disease, and this reduction paralleled the loss of tyrosine hydroxylase, the enzyme rate limiting noradrenaline synthesis.	Norepinephrine	189-202	secretagogin, EF-hand calcium binding protein	Homo sapiens	17-29
31009605-7	2019	PDE4 inhibition increased noradrenaline potency in wild type and AC5 KO, but not AC6 KO.	Norepinephrine	26-39	adenylate cyclase 5	Mus musculus	65-68
31009605-9	2019	PDE3 inhibition increased noradrenaline potency only in AC5 KO that was treated prior with PTX.	Norepinephrine	26-39	adenylate cyclase 5	Mus musculus	56-59
31156340-8	2019	The areas under the curves for the renalase-dopamine, renalase-norepinephrine and renalase-epinephrine ratios were 0.805, 95% confidence interval (CI): 0.699-0.912 (p&lt;0.001); 0.726, 95% CI: 0.594-0.859 (p=0.032); and 0.656, 95% CI: 0.520-0.791 (p=0.02).	Norepinephrine	63-77	renalase, FAD dependent amine oxidase	Homo sapiens	54-62
31156340-8	2019	The areas under the curves for the renalase-dopamine, renalase-norepinephrine and renalase-epinephrine ratios were 0.805, 95% confidence interval (CI): 0.699-0.912 (p&lt;0.001); 0.726, 95% CI: 0.594-0.859 (p=0.032); and 0.656, 95% CI: 0.520-0.791 (p=0.02).	Norepinephrine	63-77	renalase, FAD dependent amine oxidase	Homo sapiens	54-62
30856610-4	2019	This results in the release of norepinephrine onto adipose tissue inducing a drop of leptin.	Norepinephrine	31-45	leptin	Homo sapiens	85-91
31035382-5	2019	Presence of Hif2alpha resulted in similarly increased cellular dopamine and norepinephrine under hypoxia as in the control cells.	Norepinephrine	76-90	endothelial PAS domain protein 1	Homo sapiens	12-21
30401628-2	2019	An approach to mitigate the enhanced sympathetic nervous system drive is restricting the biosynthesis of noradrenaline via inhibition of the enzyme dopamine beta-hydroxylase (DbetaH), that catalyzes the hydroxylation of dopamine to noradrenaline in sympathetic nerves.	Norepinephrine	105-118	dopamine beta-hydroxylase	Rattus norvegicus	148-173
30401628-2	2019	An approach to mitigate the enhanced sympathetic nervous system drive is restricting the biosynthesis of noradrenaline via inhibition of the enzyme dopamine beta-hydroxylase (DbetaH), that catalyzes the hydroxylation of dopamine to noradrenaline in sympathetic nerves.	Norepinephrine	105-118	dopamine beta-hydroxylase	Rattus norvegicus	175-181
30401628-2	2019	An approach to mitigate the enhanced sympathetic nervous system drive is restricting the biosynthesis of noradrenaline via inhibition of the enzyme dopamine beta-hydroxylase (DbetaH), that catalyzes the hydroxylation of dopamine to noradrenaline in sympathetic nerves.	Norepinephrine	232-245	dopamine beta-hydroxylase	Rattus norvegicus	148-173
30401628-2	2019	An approach to mitigate the enhanced sympathetic nervous system drive is restricting the biosynthesis of noradrenaline via inhibition of the enzyme dopamine beta-hydroxylase (DbetaH), that catalyzes the hydroxylation of dopamine to noradrenaline in sympathetic nerves.	Norepinephrine	232-245	dopamine beta-hydroxylase	Rattus norvegicus	175-181
29685068-4	2019	Animal models, particularly mouse models carrying variants of AD-related gene(s), many of which lead to an accumulation of Abeta, suggest that a fundamental shift in depression-related monoaminergic systems (including serotonin and noradrenaline) is a strong indicator of the altered cellular function associated with the earlier(est) stages of AD-related pathology.	Norepinephrine	232-245	amyloid beta (A4) precursor protein	Mus musculus	123-128
30126894-7	2018	In response to an increased norepinephrine (NE) level, expression of beta3-adrenoceptor was significantly upregulated, and the downstream protein kinase A (PKA) pathway was activated, as indicated by enhanced phosphorylation of whole PKA substrates, in particular, the hormone-sensitive lipase (HSL) in adipocytes.	Norepinephrine	28-42	adrenergic receptor, beta 3	Mus musculus	69-87
30106035-6	2018	In essence, the literature reviewed herein supports our hypothesis of a tripartite neuroprotective role for noradrenaline in combating PD-related neuropathology and motor dysfunction via (1) inhibiting nigral microglial activation &amp; pro-inflammatory mediator production, (2) promoting the synthesis of neurotrophic factors from midbrain astrocytes and (3) downregulating alpha-synuclein gene expression and protein abundance in a beta2-AR-dependent manner.	Norepinephrine	108-121	synuclein alpha	Homo sapiens	375-390
29615637-5	2018	BRL44408 increased cardiac norepinephrine (NE) concentration in CLP rats.	Norepinephrine	27-41	coactosin-like F-actin binding protein 1	Rattus norvegicus	64-67
29166705-6	2018	The system allowed a limit of detection between 0.625 and 2.5 pg muL-1 for monoamine analytes and their metabolites, including dopamine, 3,4-dihydroxyphenylacetic acid, 3-methoxytyramine, homovanillic acid, norepinephrine, epinephrine, 3-methoxy-4-hydroxyphenylglycol, serotonin and 5-hydroxyindoleacetic acid.	Norepinephrine	207-221	mitochondrial ubiquitin ligase activator of NFKB 1	Mus musculus	65-70
29329391-0	2018	Oxidative burst and Dectin-1-triggered phagocytosis affected by norepinephrine and endocannabinoids: implications for fungal clearance under stress.	Norepinephrine	64-78	C-type lectin domain containing 7A	Homo sapiens	20-28
28895001-3	2018	Norepinephrine (NE) signaling via alpha1 receptors is primarily excitatory, working either directly on CRH neurons or through presynaptic activation of glutamate release.	Norepinephrine	0-14	corticotropin releasing hormone	Homo sapiens	103-106
30453293-2	2018	Dopamine beta-hydroxylase (DBH), a gene located in the chromosomal region 9q34, plays a crucial role in the process of converting dopamine into norepinephrine (NE).	Norepinephrine	144-158	dopamine beta-hydroxylase	Homo sapiens	0-25
30453293-2	2018	Dopamine beta-hydroxylase (DBH), a gene located in the chromosomal region 9q34, plays a crucial role in the process of converting dopamine into norepinephrine (NE).	Norepinephrine	144-158	dopamine beta-hydroxylase	Homo sapiens	27-30
29433734-9	2018	FOXO1 knockout within the PNS results in a reduction of sympathetic tone and decreased levels of brain-derived norepinephrine and lower energy expenditure.	Norepinephrine	111-125	forkhead box O1	Mus musculus	0-5
28983964-4	2018	We show that in cortical astrocytes BDNF exon IV and exon VI containing mRNAs are induced by dopamine and norepinephrine via CREB-dependent signaling and that this regulation is mediated by a mechanism that is distinct from activity-dependent CREB-mediated activation of BDNF transcription in neurons.	Norepinephrine	106-120	cAMP responsive element binding protein 1	Rattus norvegicus	125-129
28983964-4	2018	We show that in cortical astrocytes BDNF exon IV and exon VI containing mRNAs are induced by dopamine and norepinephrine via CREB-dependent signaling and that this regulation is mediated by a mechanism that is distinct from activity-dependent CREB-mediated activation of BDNF transcription in neurons.	Norepinephrine	106-120	cAMP responsive element binding protein 1	Rattus norvegicus	243-247
30454587-5	2018	UCP1 is innately inhibited by cytosolic adenosine triphosphate (ATP) and is likely activated by fatty acids released from triglycerides within the cells; this lipolysis is stimulated by norepinephrine released from the sympathetic nerves innervating the tissue.	Norepinephrine	186-200	uncoupling protein 1	Homo sapiens	0-4
28645101-0	2017	Co-localization of endogenous Arf6 and its activator EFA6D in the granular convoluted tubule cells of mouse submandibular glands under normal conditions and when stimulated by isoproterenol, noradrenaline and carbachol.	Norepinephrine	191-204	pleckstrin and Sec7 domain containing 3	Mus musculus	53-58
27836486-1	2017	Vesicular monoamine transporter 2 (VMAT2, SLC18A2) is a transmembrane transporter protein that packages dopamine, serotonin, norepinephrine, and histamine into vesicles in preparation for neurotransmitter release from the presynaptic neuron.	Norepinephrine	125-139	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	35-40
27836486-1	2017	Vesicular monoamine transporter 2 (VMAT2, SLC18A2) is a transmembrane transporter protein that packages dopamine, serotonin, norepinephrine, and histamine into vesicles in preparation for neurotransmitter release from the presynaptic neuron.	Norepinephrine	125-139	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	42-49
28835457-5	2017	Noradrenaline and adrenaline dose-dependently suppressed the release of IL-27p28 in LPS/TLR4-activated macrophages, which was independent of alpha1 adrenoceptors.	Norepinephrine	0-13	interleukin 27	Mus musculus	72-80
28887324-5	2017	Both epinephrine (EPI) and norepinephrine (NE) could directly inhibit breast cancer cell viability, as well as tumor growth in vivo EPI and NE activate the tumor suppressor Hippo signaling pathway, and the suppressive effect of exercise-conditioned serum was found to be mediated through phosphorylation and cytoplasmic retention of YAP and reduced expression of downstream target genes, for example, ANKRD1 and CTGF.	Norepinephrine	27-41	ankyrin repeat domain 1	Homo sapiens	401-407
28439935-8	2017	The upregulation of locus ceruleus tyrosine hydroxylase, upregulates norepinephrine in the cerebrospinal fluid that acts on adrenergic receptors to enhance pCREB binding to the cAMP response element, which recruits histone acetylene transferase (HAT) to the BDNF gene to enhance its transcription resulting in aggravated visceromotor response to colorectal distension.	Norepinephrine	69-83	brain derived neurotrophic factor	Homo sapiens	258-262
28438532-3	2017	The obtained results indicate that noradrenaline decreases the mean open probability of TREK-2-like channel currents by activation of beta1 but not of alpha1- and alpha2-adrenergic receptors.	Norepinephrine	35-48	potassium two pore domain channel subfamily K member 10	Rattus norvegicus	88-94
28389717-5	2017	Selective blockade of beta1 (CGP20712) or beta3 (SR59230A), but not beta2 (ICI118,551) adrenoceptors, greatly increased alpha-adrenergic constriction (norepinephrine) of aorta in female SHRs, but not in male SHRs at 12 weeks of age.	Norepinephrine	151-165	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	22-27
27761593-4	2017	We found that activation of CREB-dependent transcription reduced the calcium responses induced by ATP, noradrenaline, or endothelin-1.	Norepinephrine	103-116	cAMP responsive element binding protein 1	Homo sapiens	28-32
27986860-1	2017	We have previously shown that ONO-2952, a novel 18-kDa translocator protein (TSPO) antagonist, inhibits stress-induced accumulation of neurosteroids and noradrenaline release in the rat brain and alleviates the subsequent symptomatic responses with a brain TSPO occupancy of 50% or more.	Norepinephrine	153-166	translocator protein	Rattus norvegicus	77-81
27753095-16	2017	Noradrenaline also evoked TRPC1 channel activity and associations between TRPC1, STIM1, Galphaq and PLCbeta1, which were inhibited by STIM1 knockdown.	Norepinephrine	0-13	transient receptor potential cation channel subfamily C member 1	Homo sapiens	26-31
27753095-16	2017	Noradrenaline also evoked TRPC1 channel activity and associations between TRPC1, STIM1, Galphaq and PLCbeta1, which were inhibited by STIM1 knockdown.	Norepinephrine	0-13	transient receptor potential cation channel subfamily C member 1	Homo sapiens	74-79
27512975-7	2016	Similarly, mean plasma noradrenaline was significantly reduced for both light-intensity walking (-0.3 +- 0.1 nmol/l) and SRA (-0.6 +- 0.1 nmol/l) versus SIT, with SRA lower than light-intensity walking (P &lt; 0.05).	Norepinephrine	23-36	steroid receptor RNA activator 1	Homo sapiens	121-124
27512975-7	2016	Similarly, mean plasma noradrenaline was significantly reduced for both light-intensity walking (-0.3 +- 0.1 nmol/l) and SRA (-0.6 +- 0.1 nmol/l) versus SIT, with SRA lower than light-intensity walking (P &lt; 0.05).	Norepinephrine	23-36	steroid receptor RNA activator 1	Homo sapiens	163-166
27512975-9	2016	CONCLUSION: Interrupting prolonged sitting with brief bouts of light-intensity walking or SRA reduces resting BP and plasma noradrenaline in adults with T2D, with SRA being more effective.	Norepinephrine	124-137	steroid receptor RNA activator 1	Homo sapiens	90-93
27647372-5	2016	The provided SAR data and potent biological activity can offer useful guidelines for designing dual norepinephrine and dopamine reuptake inhibitors as effective therapeutic agents for treatment of several central nervous system diseases.	Norepinephrine	100-114	sarcosine dehydrogenase	Homo sapiens	13-16
26801076-5	2016	In addition, a negative P2XR/nAChR cross-talk was observed in the control of the evoked release of noradrenaline from rat hippocampal synaptosomes, characterized by a less-than-additive facilitatory effect upon co-activation of both receptors.	Norepinephrine	99-112	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	29-34
27106352-11	2016	CONCLUSIONS: The expression of the alpha2-AR subtypes is sensitive to 17beta-estradiol, which decreases the contractile response of (-)-noradrenaline via the alpha2B-AR subtype, and might cause changes in G-protein signaling pathway.	Norepinephrine	132-149	adrenoceptor alpha 2B	Rattus norvegicus	158-168
26581245-10	2016	In vitro analyses indicated that norepinephrine-induced DUSP1 gene expression was mediated through ADRB2 activation of cAMP-PLC-PKC-CREB signaling, which inhibits JNK-mediated phosphorylation of c-Jun and protects ovarian cancer cells from apoptosis.	Norepinephrine	33-47	adrenoceptor beta 2	Homo sapiens	99-104
26581245-10	2016	In vitro analyses indicated that norepinephrine-induced DUSP1 gene expression was mediated through ADRB2 activation of cAMP-PLC-PKC-CREB signaling, which inhibits JNK-mediated phosphorylation of c-Jun and protects ovarian cancer cells from apoptosis.	Norepinephrine	33-47	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	195-200
26787044-5	2016	However, sema 3A silencing leaded to sympathetic hyperinnervation, increased myocardial norepinephrine (NE) content and inducible VAs.	Norepinephrine	88-102	semaphorin 3A	Rattus norvegicus	9-16
26604136-8	2016	beta-adrenergic stress induced with 10 microm norepinephrine demonstrated increased susceptibility to sarcomeric disorganization (RBM20: 86 +- 10.5% versus control: 40 +- 7%; P &lt; 0.001).	Norepinephrine	46-60	RNA binding motif protein 20	Homo sapiens	130-135
27356717-2	2016	In BCa, several studies have linked beta2-adrenergic receptor activation with increased tumour growth and progression as related with Epinephrine-NorEpinephrine (E-NE) stimulation.	Norepinephrine	146-160	adrenoceptor beta 2	Homo sapiens	36-61
26393369-1	2015	The isozymes of monoamine oxidase (MAO-A and MAO-B) are important enzymes involved in the metabolism of numerous biogenic amines, including the neurotransmitters serotonin, dopamine, and norepinephrine.	Norepinephrine	187-201	monoamine oxidase B	Rattus norvegicus	45-50
26189762-5	2015	The inhibitory effect of ONO-2952 on stress-induced noradrenaline release was attenuated by co-treatment with the TSPO agonist CB34 in a dose-dependent manner.	Norepinephrine	52-65	translocator protein	Rattus norvegicus	114-118
26503701-1	2015	The transporters for norepinephrine and dopamine (NET and DAT, respectively) constitute the molecular targets for recreational drugs and therapeutics used in the treatment of psychiatric disorders.	Norepinephrine	21-35	solute carrier family 6 member 3	Homo sapiens	58-61
25921770-13	2015	Thus, the CB1 receptor-mediated inhibition of noradrenaline release from the sympathetic nerve fibres innervating the resistance vessels might play a protective role in hypertension.	Norepinephrine	46-59	cannabinoid receptor 1	Rattus norvegicus	10-13
25818584-9	2015	Norepinephrine also decreased mRNA expression of osterix, collagen I, and osteocalcin by mesenchymal stem cells at 7 and 14 d of stimulation and increased the expression of RANKL and RANKL/OPG ratio by mesenchymal stem cells at 2 h. In conclusion, CIS and UAC synergistically promote condylar subchondral bone loss and cartilage degradation; such processes are partially regulated by norepinephrine within subchondral bone.	Norepinephrine	0-14	Sp7 transcription factor 7	Mus musculus	49-56
25818584-9	2015	Norepinephrine also decreased mRNA expression of osterix, collagen I, and osteocalcin by mesenchymal stem cells at 7 and 14 d of stimulation and increased the expression of RANKL and RANKL/OPG ratio by mesenchymal stem cells at 2 h. In conclusion, CIS and UAC synergistically promote condylar subchondral bone loss and cartilage degradation; such processes are partially regulated by norepinephrine within subchondral bone.	Norepinephrine	0-14	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	189-192
25653192-0	2015	Norepinephrine preferentially modulates memory CD8 T cell function inducing inflammatory cytokine production and reducing proliferation in response to activation.	Norepinephrine	0-14	CD8a molecule	Homo sapiens	47-50
25799564-9	2015	It was observed that when alpha1B-adrenergic receptors were stimulated with noradrenaline, the receptors interacted with proteins present in early endosomes, such as the early endosomes antigen 1, Rab 5, Rab 4, and Rab 11 but not with late endosome markers, such as Rab 9 and Rab 7.	Norepinephrine	76-89	RAB9A, member RAS oncogene family	Homo sapiens	266-271
25824473-2	2015	In contrast, ADRB-2 expression and function in nonhuman primate and human ovary were not fully known but innervation and significant levels of norepinephrine (NE), which is a ligand at the ADRB-2, were reported in the ovary.	Norepinephrine	143-157	adrenoceptor beta 2	Homo sapiens	189-195
25617795-10	2015	These results indicate that the selective antagonism of alpha1A- and alpha1D-adrenoceptors results in antidepressant-like effects and that the alpha1B-subtype is the main target for the increased levels of noradrenaline caused by imipramine.	Norepinephrine	206-219	calcium channel, voltage-dependent, N type, alpha 1B subunit	Mus musculus	143-150
25561369-5	2015	RESULTS: Adrenaline(A), noradrenaline and the beta-AR agonist isoprenaline reduced N-formyl-Met-Leu-Phe (fMLP)-induced migration, CD11b/CD18 expression, and ROS production, without affecting IL-8.	Norepinephrine	24-37	integrin subunit alpha M	Homo sapiens	130-135
25132576-2	2014	However, previous findings on the association between aggregated sAA and other sympathetic markers, namely norepinephrine and epinephrine, were mixed.	Norepinephrine	107-121	amylase alpha 1A	Homo sapiens	65-68
25087915-9	2014	Targeting of brain MC4R is a promising strategy to protect HPA axis, LC-NE (locus coeruleus-norepinephrine) systems and hippocampus from overstimulation.	Norepinephrine	92-106	melanocortin 4 receptor	Rattus norvegicus	19-23
25131562-2	2014	Previous studies have shown that, in the rat medial prefrontal cortex (mPFC), CB1R agonists increase norepinephrine release, an effect that may be attributed, in part, to CB1Rs localised to noradrenergic axon terminals.	Norepinephrine	101-115	cannabinoid receptor 1	Rattus norvegicus	78-81
24696080-15	2014	CONCLUSIONS: These findings indicate that, during stress, norepinephrine, via beta2-ARs, either directly or indirectly activates CRF-releasing neurons in the BNST that interface with motivational neurocircuitry to induce reinstatement of cocaine-conditioned reward.	Norepinephrine	58-72	hemoglobin, beta adult minor chain	Mus musculus	78-83
24554716-7	2014	Clinical research also shows that serum GDF-15 levels in hypertensive patients were significant higher than in healthy volunteers and were positively correlated with the thickness of the posterior wall of the left ventricle, interventricular septum, and left ventricular mass, as well as the serum level of norepinephrine.	Norepinephrine	307-321	growth differentiation factor 15	Homo sapiens	40-46
24670922-5	2014	In synthesis, norepinephrine downregulated levels of mRNA for type I to type III collagen in ratio, but increased the elastin gene transcription and glycosaminoglycan levels in valve interstitial cells greatly.	Norepinephrine	14-28	elastin	Homo sapiens	118-125
24670922-7	2014	Diminished MMP inhibitor expression, TIMP2, also could reflect this effect in the norepinephrine medium.	Norepinephrine	82-96	TIMP metallopeptidase inhibitor 2	Homo sapiens	37-42
24297249-1	2014	We found previously that stimulation of natriuretic peptide receptor (NPR)-B by C-type natriuretic peptide (CNP) in failing rat ventricle potentiates beta1-adrenoceptor (beta1-AR)-mediated inotropic response to noradrenaline through cGMP-mediated inhibition of phosphodiesterase (PDE) 3, thereby enhancing cAMP-mediated signalling.	Norepinephrine	211-224	natriuretic peptide C	Rattus norvegicus	80-106
24297249-1	2014	We found previously that stimulation of natriuretic peptide receptor (NPR)-B by C-type natriuretic peptide (CNP) in failing rat ventricle potentiates beta1-adrenoceptor (beta1-AR)-mediated inotropic response to noradrenaline through cGMP-mediated inhibition of phosphodiesterase (PDE) 3, thereby enhancing cAMP-mediated signalling.	Norepinephrine	211-224	natriuretic peptide C	Rattus norvegicus	108-111
24297249-9	2014	We identified several small molecule NPR-B antagonists by high throughput screening and show in a functional heart preparation that blocking NPR-B stimulation with a small molecule compound can reduce the potentiating effect of CNP on the beta1-AR-mediated inotropic response to noradrenaline.	Norepinephrine	279-292	natriuretic peptide C	Rattus norvegicus	228-231
23489141-4	2013	The effects of (-)-noradrenaline, mediated through beta1 adrenoceptors (beta2 adrenoceptors blocked with ICI118551), and (-)-adrenaline, mediated through beta2 adrenoceptors (beta1 adrenoceptors blocked with CGP20712A), were assessed in the absence and presence of PDE inhibitors.	Norepinephrine	15-32	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	175-180
23333670-0	2013	c-Fos activity mapping reveals differential effects of noradrenaline and serotonin depletion on the regulation of ocular dominance plasticity in rats.	Norepinephrine	55-68	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
23333670-3	2013	Applying this new method, here we studied the unique modification of the degree of c-Fos expression induced in the visual cortex, in that endogenous noradrenaline (NA) and serotonin (5HT) in the cortex were significantly reduced, respectively by specific pharmacological agents.	Norepinephrine	149-162	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	83-88
21898033-6	2012	The present study aims to examine the association between three common BDNF single-nucleotid polymorphisms (SNPs; rs7103411, rs7124442, and rs6265) and depressive symptoms in a community-based elderly population taking into account the serum levels of four neurotransmitters, serotonin, dopamine, adrenalin, and noradrenalin, as potential mediating factors.	Norepinephrine	312-324	brain derived neurotrophic factor	Homo sapiens	71-75
22954623-0	2012	Acute stress responses in salivary alpha-amylase predict increases of plasma norepinephrine.	Norepinephrine	77-91	amylase alpha 1A	Homo sapiens	26-48
22834682-3	2012	Furthermore, [Dmt(1) ]DALDA inhibits norepinephrine re-uptake and is a mitochondria-targeted antioxidant.	Norepinephrine	37-51	RoBo-1	Rattus norvegicus	14-20
26593027-1	2012	Monoamine oxidase (MAO), which exists in two isozymic forms, MAO A and MAO B, is an important flavoenzyme responsible for the metabolism of amine neurotransmitters such as dopamine, serotonin, and norepinephrine.	Norepinephrine	197-211	monoamine oxidase B	Homo sapiens	71-76
22454242-3	2012	We hypothesized that DAOA polymorphisms are associated with dopamine, serotonin and noradrenaline turnover in the human brain.	Norepinephrine	84-97	D-amino acid oxidase activator	Homo sapiens	21-25
22582116-3	2012	In cells perfused with Ca(2+)-free Krebs Ringer bicarbonate solution (KRBS), brief exposures to caffeine (30 mM) and norepinephrine (300 muM), which activate SR ryanodine and inositol trisphosphate receptors (RyR, IP(3)R), respectively, or 4% O(2) caused rapid transient increases in [Ca(2+)](i), indicating intracellular Ca(2+) release.	Norepinephrine	117-131	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	214-220
22582116-6	2012	The IP(3)R antagonist xestospongin C (XeC, 0.1 muM) blocked Ca(2+) release to norepinephrine and hypoxia but not caffeine.	Norepinephrine	78-92	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	4-10
22441984-3	2012	The present study tests the hypothesis that increased norepinephrine causes epigenetic repression of PKCepsilon gene in the heart via Nox1-dependent reactive oxygen species (ROS) production.	Norepinephrine	54-68	NADPH oxidase 1	Rattus norvegicus	134-138
22626578-0	2012	Adrenomedullin inhibits norepinephrine-induced contraction of rat seminal vesicle.	Norepinephrine	24-38	adrenomedullin	Rattus norvegicus	0-14
22890201-2	2012	Both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) regulate neurochemistry by degrading monoamine neurotransmitters (serotonin, dopamine, and norepinephrine).	Norepinephrine	156-170	monoamine oxidase B	Homo sapiens	37-56
22890201-2	2012	Both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) regulate neurochemistry by degrading monoamine neurotransmitters (serotonin, dopamine, and norepinephrine).	Norepinephrine	156-170	monoamine oxidase B	Homo sapiens	58-63
22322975-6	2012	Functionally, ANG II-induced downregulation of RhoA-GEFs is associated with decreased Rho kinase activation in response to endothelin-1, norepinephrine, and U-46619.	Norepinephrine	137-151	ras homolog family member A	Rattus norvegicus	47-51
21702050-4	2012	Our data are as follows: (a) The calcineurin inhibitor cyclosporine A (CsA) blocked norepinephrine secretion induced by ligands of either CRF type 1 (CRF(1)) or 2 (CRF(2)) receptors on PC12 cells.	Norepinephrine	84-98	corticotropin releasing hormone receptor 1	Rattus norvegicus	138-148
21702050-4	2012	Our data are as follows: (a) The calcineurin inhibitor cyclosporine A (CsA) blocked norepinephrine secretion induced by ligands of either CRF type 1 (CRF(1)) or 2 (CRF(2)) receptors on PC12 cells.	Norepinephrine	84-98	corticotropin releasing hormone receptor 1	Rattus norvegicus	150-156
21702050-4	2012	Our data are as follows: (a) The calcineurin inhibitor cyclosporine A (CsA) blocked norepinephrine secretion induced by ligands of either CRF type 1 (CRF(1)) or 2 (CRF(2)) receptors on PC12 cells.	Norepinephrine	84-98	corticotropin releasing hormone receptor 2	Rattus norvegicus	164-169
21702050-10	2012	(f) p38-MAPK and Tpl2 were crucial intermediates for both CRF(1) and CRF(2)-induced norepinephrine production, while AKT1 affected only CRF(2)-induced norepinephrine production.	Norepinephrine	84-98	mitogen-activated protein kinase kinase kinase 8	Rattus norvegicus	17-21
21702050-10	2012	(f) p38-MAPK and Tpl2 were crucial intermediates for both CRF(1) and CRF(2)-induced norepinephrine production, while AKT1 affected only CRF(2)-induced norepinephrine production.	Norepinephrine	84-98	corticotropin releasing hormone receptor 1	Rattus norvegicus	58-64
21702050-10	2012	(f) p38-MAPK and Tpl2 were crucial intermediates for both CRF(1) and CRF(2)-induced norepinephrine production, while AKT1 affected only CRF(2)-induced norepinephrine production.	Norepinephrine	84-98	corticotropin releasing hormone receptor 2	Rattus norvegicus	69-74
21702050-10	2012	(f) p38-MAPK and Tpl2 were crucial intermediates for both CRF(1) and CRF(2)-induced norepinephrine production, while AKT1 affected only CRF(2)-induced norepinephrine production.	Norepinephrine	151-165	corticotropin releasing hormone receptor 2	Rattus norvegicus	69-74
21702050-10	2012	(f) p38-MAPK and Tpl2 were crucial intermediates for both CRF(1) and CRF(2)-induced norepinephrine production, while AKT1 affected only CRF(2)-induced norepinephrine production.	Norepinephrine	151-165	corticotropin releasing hormone receptor 2	Rattus norvegicus	136-141
22405824-0	2012	Desipramine selectively potentiates norepinephrine-elicited ERK1/2 activation through the alpha2A adrenergic receptor.	Norepinephrine	36-50	adrenoceptor alpha 2A	Homo sapiens	90-117
22200605-0	2012	Embryonic lethality in mice lacking mismatch-specific thymine DNA glycosylase is partially prevented by DOPS, a precursor of noradrenaline.	Norepinephrine	125-138	thymine DNA glycosylase	Mus musculus	54-77
22200605-5	2012	On the other hand, the levels of noradrenaline in 10.5 dpc whole embryos, which is necessary for normal embryogenesis, were dramatically reduced in Tdg (-/-) embryos.	Norepinephrine	33-46	thymine DNA glycosylase	Mus musculus	148-151
22200605-11	2012	These results suggest that embryonic lethality in Tdg (-/-) embryos is due, in part, to the reduction of noradrenaline levels.	Norepinephrine	105-118	thymine DNA glycosylase	Mus musculus	50-53
22060292-4	2011	KEY FINDINGS: Curcumin at a concentration of 8 microm was found to suppress the increase in cell size, protein content and enhanced marker gene expression (ANF) caused by noradrenaline.	Norepinephrine	171-184	natriuretic peptide A	Rattus norvegicus	156-159
21947296-4	2011	Using myography, arteries from NBCn1 knockout mice showed reduced acetylcholine-induced NO-mediated relaxations and lower rho-kinase-dependent norepinephrine-stimulated smooth muscle Ca2+ sensitivity.	Norepinephrine	143-157	solute carrier family 4, sodium bicarbonate cotransporter, member 7	Mus musculus	31-36
21885739-1	2011	The norepinephrine transporter (NET) transports norepinephrine from the synapse into presynaptic neurons, where norepinephrine regulates signaling pathways associated with cardiovascular effects and behavioral traits via binding to various receptors (e.g., beta2-adrenergic receptor).	Norepinephrine	4-18	adrenoceptor beta 2	Homo sapiens	257-282
21885739-1	2011	The norepinephrine transporter (NET) transports norepinephrine from the synapse into presynaptic neurons, where norepinephrine regulates signaling pathways associated with cardiovascular effects and behavioral traits via binding to various receptors (e.g., beta2-adrenergic receptor).	Norepinephrine	48-62	adrenoceptor beta 2	Homo sapiens	257-282
21613371-6	2011	In functional studies, phenylephrine and noradrenaline produced dose-dependent constriction of ophthalmic arteries that was similar in wild-type, alpha(1B)-AR(-/-), and alpha(1D)-AR(-/-) mice.	Norepinephrine	41-54	calcium channel, voltage-dependent, N type, alpha 1B subunit	Mus musculus	146-154
21361697-3	2011	In order to study the lateral diffusion of beta(2)-adrenergic receptors (beta(2)AR) complexed with fluorescently labeled noradrenaline (Alexa-NA) in plasma membranes of A549 cells, trajectories of single receptor-ligand complexes were monitored using single-particle tracking.	Norepinephrine	121-134	adrenoceptor beta 2	Homo sapiens	43-71
21361697-3	2011	In order to study the lateral diffusion of beta(2)-adrenergic receptors (beta(2)AR) complexed with fluorescently labeled noradrenaline (Alexa-NA) in plasma membranes of A549 cells, trajectories of single receptor-ligand complexes were monitored using single-particle tracking.	Norepinephrine	121-134	adrenoceptor beta 2	Homo sapiens	73-82
21087442-8	2010	To evaluate the role of monoamine transporters in the psychostimulant-induced expression of FosB/DeltaFosB, we tested the antidepressant drugs reboxetine, nortriptyline, fluoxetine and venlafaxine (which target the noradrenaline and/or the 5-hydroxytryptamine transporters), the 5-hydroxytryptamine releasing agent dexfenfluramine, and the dopamine transporter inhibitor GBR12909.	Norepinephrine	215-228	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	92-96
20954794-1	2010	The alpha(1)-adrenergic receptor (AR) subtypes (alpha(1a), alpha(1b), and alpha(1d)) mediate several physiological effects of epinephrine and norepinephrine.	Norepinephrine	142-156	calcium channel, voltage-dependent, N type, alpha 1B subunit	Mus musculus	59-67
20837485-4	2010	In this beta(2)AR sensor, norepinephrine caused signals that amounted to only  50% of those induced by epinephrine and the standard "full" agonist isoproterenol.	Norepinephrine	26-40	adrenoceptor beta 2	Homo sapiens	8-17
20837485-5	2010	Furthermore, norepinephrine-induced changes in the beta(2)AR FRET sensor were slower than those induced by epinephrine (rate constants, 47 versus 128 ms).	Norepinephrine	13-27	adrenoceptor beta 2	Homo sapiens	51-60
20837485-9	2010	We conclude that partial agonism of norepinephrine at the beta(2)AR is related to the induction of a different active conformation and that this conformation is efficient in signaling to G(s) and less efficient in signaling to beta-arrestin2.	Norepinephrine	36-50	adrenoceptor beta 2	Homo sapiens	58-67
20728435-5	2010	A small number of HSD2 immunoreactive neurons was also labeled for dopamine-beta-hydroxylase (DBH), an enzyme involved in norepinephrine biosynthesis.	Norepinephrine	122-136	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	18-22
20810904-6	2010	Norepinephrine and isoproterenol upregulated the expression of Abeta receptor mFPR2, a mouse homolog of human formyl peptide receptor FPR2, through activation of beta(2)AR in microglia.	Norepinephrine	0-14	formyl peptide receptor 2	Mus musculus	78-83
20810904-6	2010	Norepinephrine and isoproterenol upregulated the expression of Abeta receptor mFPR2, a mouse homolog of human formyl peptide receptor FPR2, through activation of beta(2)AR in microglia.	Norepinephrine	0-14	adrenoceptor beta 2	Homo sapiens	162-171
20810904-7	2010	Norepinephrine also induced mFPR2 expression in mouse brain.	Norepinephrine	0-14	formyl peptide receptor 2	Mus musculus	28-33
20554931-4	2010	In addition to a critical role in intranuclear oxytocin release during lactation, norepinephrine has also been shown to stimulate central oxytocin during gestation.	Norepinephrine	82-96	oxytocin/neurophysin I prepropeptide	Homo sapiens	138-146
20739005-1	2010	LeuT is a member of the neurotransmitter/sodium symporter family, which includes the neuronal transporters for serotonin, norepinephrine, and dopamine.	Norepinephrine	122-136	Leucine transport, high	Homo sapiens	0-4
20406628-0	2010	Combined treatment with MAO-A inhibitor and MAO-B inhibitor increases extracellular noradrenaline levels more than MAO-A inhibitor alone through increases in beta-phenylethylamine.	Norepinephrine	84-97	monoamine oxidase B	Rattus norvegicus	44-49
20406628-11	2010	Our results suggest that the combined treatment with a MAO-A inhibitor and a MAO-B inhibitor strengthens antidepressant effects because the combined treatment increases extracellular noradrenaline levels more than a MAO-A inhibitor alone through increases in beta-phenylethylamine.	Norepinephrine	183-196	monoamine oxidase B	Rattus norvegicus	77-82
20118201-5	2010	The elevation of the plasma norepinephrine level caused by the subtotal nephrectomy + salt loading was also reduced in the V1aR KO mice.	Norepinephrine	28-42	arginine vasopressin receptor 1A	Mus musculus	123-127
19538471-1	2010	By employing a pharmacological approach, we have shown that phospholipase C (PLC) activity is involved in the regulation of gene expression of transcription factors such as c-Fos and c-Jun in cardiomyocytes in response to norepinephrine (NE).	Norepinephrine	222-236	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	175-178
19538471-1	2010	By employing a pharmacological approach, we have shown that phospholipase C (PLC) activity is involved in the regulation of gene expression of transcription factors such as c-Fos and c-Jun in cardiomyocytes in response to norepinephrine (NE).	Norepinephrine	222-236	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	183-188
20056676-2	2010	Here, we show that animals with a Col4a1 missense mutation (Col4a1(+/Raw)) display focal detachment of the endothelium from the media and age-dependent defects in vascular function including a reduced response to nor-epinephrine.	Norepinephrine	213-228	collagen, type IV, alpha 1	Mus musculus	34-40
20056676-2	2010	Here, we show that animals with a Col4a1 missense mutation (Col4a1(+/Raw)) display focal detachment of the endothelium from the media and age-dependent defects in vascular function including a reduced response to nor-epinephrine.	Norepinephrine	213-228	collagen, type IV, alpha 1	Mus musculus	60-66
20036647-5	2010	Intra-arterial administration of cholecystokinin-8 (CCK) at the dose of 50 mg/kg was used to induce oxytocin and noradrenaline release.	Norepinephrine	113-126	cholecystokinin	Rattus norvegicus	33-50
20036647-5	2010	Intra-arterial administration of cholecystokinin-8 (CCK) at the dose of 50 mg/kg was used to induce oxytocin and noradrenaline release.	Norepinephrine	113-126	cholecystokinin	Rattus norvegicus	52-55
20036647-8	2010	Central administration of leptin significantly reduced both plasma oxytocin and hypothalamic noradrenaline responses to CCK at 20 min following the treatments.	Norepinephrine	93-106	cholecystokinin	Rattus norvegicus	120-123
19883655-3	2010	Calcineurin-mAKAPbeta complex formation is increased in the presence of Ca(2+)/calmodulin and in norepinephrine-stimulated primary cardiac myocytes.	Norepinephrine	97-111	A kinase (PRKA) anchor protein 6	Mus musculus	12-21
19883655-4	2010	This binding is of functional significance because myocytes exhibit diminished norepinephrine-stimulated hypertrophy when expressing a mAKAPbeta mutant incapable of binding calcineurin.	Norepinephrine	79-93	A kinase (PRKA) anchor protein 6	Mus musculus	135-144
19818755-0	2010	Noradrenaline induces IL-1ra and IL-1 type II receptor expression in primary glial cells and protects against IL-1beta-induced neurotoxicity.	Norepinephrine	0-13	interleukin 1 receptor antagonist	Rattus norvegicus	22-28
19818755-6	2010	Here we report that noradrenaline induces production of IL-1ra and IL-1RII from primary rat mixed glial cells.	Norepinephrine	20-33	interleukin 1 receptor antagonist	Rattus norvegicus	56-62
19818755-8	2010	Our results demonstrate that the ability of noradrenaline to induce IL-1ra and IL-1RII is mediated via beta-adrenoceptor activation and downstream activation of protein kinase A and extracellular signal-regulated kinase (ERK).	Norepinephrine	44-57	interleukin 1 receptor antagonist	Rattus norvegicus	68-74
19968887-4	2009	RESULTS: The activation of naive CD8+ T lymphocytes by CD3/CD28 cross-linking was inhibited by norepinephrine and dopamine, which was caused by a downregulation of interleukin (IL)-2 expression via Erk1/2 and NF-kappaB inhibition.	Norepinephrine	95-109	CD8a molecule	Homo sapiens	33-36
19693491-16	2009	The PDE2-selective inhibitor erythro-9-[2-hydroxy-3-nonyl]adenine caused marginal bradycardia at 30 microM and tended to reduce the chronotropic potency of (-)-noradrenaline.	Norepinephrine	156-173	phosphodiesterase 2A	Rattus norvegicus	4-8
19695215-10	2009	These findings indicate that norepinephrine stimulates DNA synthesis via alpha1-adrenergic receptors and downstream Ca(2+)/PKC and ERK1/2 activation in rBMSCs.	Norepinephrine	29-43	protein kinase C, gamma	Rattus norvegicus	123-126
19643091-8	2009	MSG- and vehicle-treated hamsters given an exogenous norepinephrine challenge showed identical increases in the duration and peak of T(IBAT).	Norepinephrine	53-67	solute carrier family 10 member 2	Homo sapiens	135-139
19596829-12	2009	These results suggest that PP36 can preserve heart function during the recovery from acute ischemic injury, and may modulate the cardiac norepinephrine release and eNOS protein level.	Norepinephrine	137-151	linker for activation of T cells	Rattus norvegicus	27-31
19690620-1	2009	BACKGROUND: Candidate genes of psychological importance include 5HT2A, 5HT2C, and COMT, implicated in the serotonin, noradrenaline and dopamine pathways, which also may be involved in regulation of energy balance.	Norepinephrine	117-130	5-hydroxytryptamine receptor 2C	Homo sapiens	71-76
19413597-0	2009	p38 mitogen-activated protein kinase (MAPK) is activated by noradrenaline and serves a cardioprotective role, whereas adrenaline induces p38 MAPK dephosphorylation.	Norepinephrine	60-73	adapter molecule crk	Gallus gallus	0-3
19413597-2	2009	The aim of the present study was to investigate the role of p38 mitogen-activated protein kinases (MAPK) in mediating the effect of noradrenaline (NA) on cardiomyocyte cell viability.	Norepinephrine	132-145	adapter molecule crk	Gallus gallus	60-63
19632578-7	2009	Release patterns included epinephrine and dopamine peaks at the time of BD and a norepinephrine peak 1 hour later.	Norepinephrine	81-95	pseudopodium enriched atypical kinase 1	Homo sapiens	96-102
19420300-7	2009	However, beta(2)-adrenoceptor-mediated Ca(2+) release was independent of measurable increases in phospholipase C activity and resistant to inhibitors of protein kinases A and C. Interestingly, single-cell imaging demonstrated that particularly lower concentrations of muscarinic receptor agonists facilitated marked oscillatory Ca(2+) signaling to noradrenaline.	Norepinephrine	348-361	adrenoceptor beta 2	Homo sapiens	9-29
19403649-0	2009	Mice lacking the ADP ribosyl cyclase CD38 exhibit attenuated renal vasoconstriction to angiotensin II, endothelin-1, and norepinephrine.	Norepinephrine	121-135	CD38 antigen	Mus musculus	37-41
19285120-4	2009	Dopamine-beta-hydroxylase (DbetaH), the enzyme synthesizing noradrenaline was examined in the locus coeruleus (LC) in these same cats.	Norepinephrine	60-73	dopamine beta-hydroxylase	Felis catus	0-25
19285120-4	2009	Dopamine-beta-hydroxylase (DbetaH), the enzyme synthesizing noradrenaline was examined in the locus coeruleus (LC) in these same cats.	Norepinephrine	60-73	dopamine beta-hydroxylase	Felis catus	27-33
19489787-6	2009	Further results of Western blotting found that the protein expression of tyrosine hydroxylase and synapsin I (especially its active form, synapsin I phosphoSer603) was also down-regulated, which were directly related to synthesis and release of norepinephrine, respectively.	Norepinephrine	245-259	synapsin I	Rattus norvegicus	98-108
19489787-6	2009	Further results of Western blotting found that the protein expression of tyrosine hydroxylase and synapsin I (especially its active form, synapsin I phosphoSer603) was also down-regulated, which were directly related to synthesis and release of norepinephrine, respectively.	Norepinephrine	245-259	synapsin I	Rattus norvegicus	138-148
19489787-7	2009	All the results suggest that Y-27632 is able to down-regulate norepinephrine synthesis and release, the direct mechanism of which may be associated with down-regulation on expression of some proteins, including tyrosine hydroxylase and synapsin I.	Norepinephrine	62-76	synapsin I	Rattus norvegicus	236-246
19463744-8	2009	In the mesenteric arterial segments pre-contracted with norepinephrine (0.001-10 microM), the maximal relaxation rate induced by acetylcholine (10 microM) in UCN-treated group (about 93.3%) was higher than that in SHR control group (about 40.0%) (n=6, P&lt;0.01).	Norepinephrine	56-70	urocortin	Rattus norvegicus	158-161
19022290-1	2009	Biogenic amine transporters for serotonin, norepinephrine and dopamine (SERT, NET and DAT respectively), are the key players terminating transmission of these amines in the central nervous system by their high-affinity uptake.	Norepinephrine	43-57	solute carrier family 6 member 3	Homo sapiens	86-89
19120138-5	2008	HPA axis responses to IL-1beta and CCK can be reinstated in pregnant rats by systemic administration of the opioid receptor antagonist naloxone, and when infused directly into the PVN, naloxone restores noradrenaline release in the PVN following IL-1beta treatment.	Norepinephrine	203-216	cholecystokinin	Rattus norvegicus	35-38
18781277-6	2008	The results suggest that BDNF gene variation participates in regulation of norepinephrine turnover rates in the central nervous system of human subjects.	Norepinephrine	75-89	brain derived neurotrophic factor	Homo sapiens	25-29
18845978-1	2008	PURPOSE: To examine the influence of a selective noradrenaline reuptake inhibitor (SNRI) on the exercise-induced increase in circulating brain-derived neurotrophic factor (BDNF).	Norepinephrine	49-62	brain derived neurotrophic factor	Homo sapiens	137-170
18845978-1	2008	PURPOSE: To examine the influence of a selective noradrenaline reuptake inhibitor (SNRI) on the exercise-induced increase in circulating brain-derived neurotrophic factor (BDNF).	Norepinephrine	49-62	brain derived neurotrophic factor	Homo sapiens	172-176
18775326-2	2008	In lymphoid organs, the neurotransmitter norepinephrine stimulates beta(2)-adrenergic receptors on B lymphocytes to promote CREB-dependent expression of genes like the B cell Oct 2 coactivator (OCA-B).	Norepinephrine	41-55	POU domain, class 2, associating factor 1	Mus musculus	194-199
18474603-5	2008	Furthermore, the C-terminal pro-TRH-derived peptides were more efficiently released in response to KCl and norepinephrine, a natural secretagogue of TRH.	Norepinephrine	107-121	thyrotropin releasing hormone	Mus musculus	28-35
18474603-5	2008	Furthermore, the C-terminal pro-TRH-derived peptides were more efficiently released in response to KCl and norepinephrine, a natural secretagogue of TRH.	Norepinephrine	107-121	thyrotropin releasing hormone	Mus musculus	32-35
18480676-3	2008	Among these are several genes associated with the catecholaminergic system including the dopamine receptor genes (DRD4 and DRD5), the dopamine transporter gene, and the gene for dopamine beta-hydroxylase, which catalyzes conversion of dopamine to norepinephrine.	Norepinephrine	247-261	solute carrier family 6 member 3	Homo sapiens	134-154
18177483-13	2008	We conclude that noradrenaline-induced increases in the expression of NHE-3, NBC-1, BSC-1 and aquaporin-2 are likely to play an important role in the regulation of salt and water transport by noradrenaline in the kidney and may explain, at least in part, the altered renal sodium and water handling associated with overactivation of the sympathetic system.	Norepinephrine	192-205	solute carrier family 12 member 1	Rattus norvegicus	84-89
18387300-1	2008	SAR for dual serotonin &amp; noradrenaline reuptake inhibition.	Norepinephrine	29-42	sarcosine dehydrogenase	Homo sapiens	0-3
18187403-3	2008	We have studied the sites of cPLA(2) phosphorylation and their significance in arachidonic acid (AA) release in response to norepinephrine (NE) in vivo in rabbit vascular smooth muscle cells (VSMCs) using specific anti-phospho-S515- and -S505 cPLA(2) antibodies and by mutagenesis of S515 and S505 to alanine.	Norepinephrine	124-138	cytosolic phospholipase A2	Oryctolagus cuniculus	29-35
18364034-0	2008	Matrix metalloproteinases MMP2 and MMP9 are upregulated by noradrenaline in the mouse neuroendocrine hypothalamus.	Norepinephrine	59-72	matrix metallopeptidase 2	Mus musculus	26-30
18364034-5	2008	We investigated the possible regulation of the two gelatinases, MMP2 and MMP9, by noradrenaline (NA) in the mouse neuroendocrine hypothalamus.	Norepinephrine	82-95	matrix metallopeptidase 2	Mus musculus	64-68
18083901-4	2008	We identified the expression of the paxillin homologue hydrogen peroxide-inducible clone-5 (Hic-5) and showed its activation by norepinephrine (NE) in a Src-dependent manner.	Norepinephrine	128-142	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	153-156
18055114-3	2008	The distribution of CB1 receptors on noradrenergic fibers in the frontal cortex suggests this may be one potential site for the regulation of norepinephrine release.	Norepinephrine	142-156	cannabinoid receptor 1	Rattus norvegicus	20-23
18240382-0	2008	1-(2-Phenoxyphenyl)methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity.	Norepinephrine	56-69	sarcosine dehydrogenase	Homo sapiens	33-36
17681645-1	2008	Brain-derived neurotrophic factor (BDNF) synthesis in astrocytes induced by noradrenaline (NA) is a receptor-mediated process utilizing two parallel adrenergic pathways: beta1/beta2-adrenergic/cAMP and the novel alpha1-adrenergic/PKC pathway.	Norepinephrine	76-89	brain-derived neurotrophic factor	Rattus norvegicus	0-33
17681645-1	2008	Brain-derived neurotrophic factor (BDNF) synthesis in astrocytes induced by noradrenaline (NA) is a receptor-mediated process utilizing two parallel adrenergic pathways: beta1/beta2-adrenergic/cAMP and the novel alpha1-adrenergic/PKC pathway.	Norepinephrine	76-89	brain-derived neurotrophic factor	Rattus norvegicus	35-39
18157476-7	2007	The results suggest that noradrenaline release secondary to the activation of kappa-bungarotoxin-sensitive nAChRs participates in LTP-like response induced by nicotine in the hippocampal CA1 region.	Norepinephrine	25-38	carbonic anhydrase 1	Homo sapiens	187-190
17171299-6	2007	Using our well, established three-dimensional collagen-based cell migration assay, we show that engagement of N-cadherin results in a significant decrease of the spontaneous and the norepinephrine-induced migration of MDA-MB-468 breast carcinoma cells, which was due to an increase in the average break length.	Norepinephrine	182-196	cadherin 2	Homo sapiens	110-120
17974982-7	2007	Regarding the effects of STAT3 activation, exposure to norepinephrine resulted in an increase in invasion and matrix metalloproteinase (MMP-2 and MMP-9) production.	Norepinephrine	55-69	matrix metallopeptidase 2	Mus musculus	136-141
17951539-1	2007	To examine whether norepinephrine, through activation of alpha1b-adrenergic receptor, regulates male fertility and testicular functions, we used alpha1b-adrenergic receptor knockout (alpha1b-AR-KO) mice.	Norepinephrine	19-33	calcium channel, voltage-dependent, N type, alpha 1B subunit	Mus musculus	57-64
17628002-6	2007	In contrast, the effect of TSA on the norepinephrine induction of the c-fos mRNA was stimulatory.	Norepinephrine	38-52	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	70-75
17612521-6	2007	Compared to group D, group Din was characterized by diminished blood glucose concentration ( approximately 1.6 fold), reduced systolic and diastolic blood pressure ( approximately 1.3 fold) and heart rate ( approximately 1.6 fold), as well as by increased contractile response of the renal artery to noradrenaline ( approximately 1.84 fold) and of the impeded vasodilator response to acetylcholine ( approximately 1.81 fold) and sodium nitroprusside ( approximately 1.42 fold).	Norepinephrine	300-313	RIKEN cDNA 4930453N24 gene	Mus musculus	27-30
17565006-4	2007	However, we found that the neurogenic contractile response of vasa deferentia from Entpd1-null (CD39(-/-)) mice was attenuated and accompanied by reduced activity of pre- and postsynaptic P2XR, whereas contractile responses to K(+) or norepinephrine remained intact.	Norepinephrine	235-249	ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	83-89
17565006-5	2007	In addition, the magnitude of ATP and norepinephrine exocytosis from cardiac synaptosomes was decreased in CD39(-/-) mice.	Norepinephrine	38-52	ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	107-111
17565006-12	2007	Our findings emphasize the cardioprotective role of neuronal CD39: by reducing presynaptic facilitatory effects of neurotransmitter ATP, CD39 attenuates norepinephrine release and its dysfunctional consequences.	Norepinephrine	153-167	ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	61-65
17565006-12	2007	Our findings emphasize the cardioprotective role of neuronal CD39: by reducing presynaptic facilitatory effects of neurotransmitter ATP, CD39 attenuates norepinephrine release and its dysfunctional consequences.	Norepinephrine	153-167	ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	137-141
17597580-1	2007	Monoamine oxidase B (MAO-B) functions in the deamination of monoamines, including dopamine and norepinephrine.	Norepinephrine	95-109	monoamine oxidase B	Homo sapiens	0-19
17597580-1	2007	Monoamine oxidase B (MAO-B) functions in the deamination of monoamines, including dopamine and norepinephrine.	Norepinephrine	95-109	monoamine oxidase B	Homo sapiens	21-26
17569658-5	2007	In contrast, we show that PKCdelta-Thr(505) phosphorylation dynamically increases in cardiomyocytes treated with phorbol 12-myristate 13-acetate or the alpha(1)-adrenergic receptor agonist norepinephrine via a mechanism that requires novel PKC isoform activity and not phosphoinositide-dependent kinase-1.	Norepinephrine	189-203	protein kinase C, delta	Mus musculus	26-34
17569658-5	2007	In contrast, we show that PKCdelta-Thr(505) phosphorylation dynamically increases in cardiomyocytes treated with phorbol 12-myristate 13-acetate or the alpha(1)-adrenergic receptor agonist norepinephrine via a mechanism that requires novel PKC isoform activity and not phosphoinositide-dependent kinase-1.	Norepinephrine	189-203	protein kinase C, delta	Mus musculus	26-29
17620967-5	2007	The Rho kinase inhibitor Y-27,632 caused a significantly greater inhibition of the contractile response to various agents (phenylephrine, norepinephrine, U46,619 and K) in MA of Ang II-14d compared to SHAM.	Norepinephrine	138-152	angiogenin	Rattus norvegicus	178-181
17507162-9	2007	In addition, Ca(2+) currents were inhibited in a voltage-dependent manner following exposure to oxotremorine-M (Oxo-M), norepinephrine and ATP via muscarinic acetylcholine receptor 2 (M(2) AChR) subtype, adrenergic and P2Y purinergic receptors, respectively.	Norepinephrine	120-134	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	189-193
17327373-8	2007	We found that norepinephrine-induced lipolysis was positively correlated with HSL protein levels (P &lt; 0.0001) but not with ATGL protein.	Norepinephrine	14-28	lipase E, hormone sensitive type	Homo sapiens	78-81
17428549-3	2007	In two experiments using CD-1 mice, we demonstrate that intraperitoneal administration of IFN-alpha dose dependently influences plasma corticosterone and sickness behaviors, and modestly influences norepinephrine turnover in brain.	Norepinephrine	198-212	interferon alpha	Mus musculus	90-99
17318500-0	2007	The effects of both noradrenaline and CGP12177, mediated through human beta1 -adrenoceptors, are reduced by PDE3 in human atrium but PDE4 in CHO cells.	Norepinephrine	20-33	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	71-76
17350522-5	2007	There is a close association between salivary alpha-amylase and plasma norepinephrine under stressful physical conditions.	Norepinephrine	71-85	amylase alpha 1A	Homo sapiens	37-59
17224717-3	2007	The current study measured SERT occupancy and modulation of DAT by the serotonin/norepinephrine reuptake inhibitor (SNRI) venlafaxine using [123I]2beta-carbomethoxy-3beta-(4-iodophenyl)-tropane SPECT.	Norepinephrine	81-95	solute carrier family 6 member 3	Homo sapiens	60-63
17113043-3	2007	In an effort to elucidate whether cannabinoid (CB1) receptors are positioned to presynaptically modulate norepinephrine release in the frontal cortex, immunocytochemical detection of the CB1 receptor and the catecholamine-synthesizing enzyme dopamine-beta-hydroxylase (DbetaH) was performed using confocal immunofluorescence microscopy and immunoelectron microscopy in rat brain.	Norepinephrine	105-119	cannabinoid receptor 1	Rattus norvegicus	47-50
17113043-7	2007	In conclusion, the present neuroanatomical data suggest that cortical norepinephrine release may be modulated, in part, by CB1 receptors that are presynaptically distributed on noradrenergic axon terminals.	Norepinephrine	70-84	cannabinoid receptor 1	Rattus norvegicus	123-126
16876982-0	2007	Norepinephrine induces BDNF and activates the PI-3K and MAPK cascades in embryonic hippocampal neurons.	Norepinephrine	0-14	brain derived neurotrophic factor	Homo sapiens	23-27
17320309-5	2007	Recent findings indicate that diazepam exerts an inhibitory activity on different isoforms of the enzyme cyclic nucleotide phosphodiesterase, which can be found in the heart muscle and also show that diazepam potentate the positive inotropic effect of both noradrenaline and adrenaline, which subsequently leads to increase in myocardial contractility.	Norepinephrine	257-270	phosphodiesterase 3B	Homo sapiens	105-140
17079456-0	2006	Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells.	Norepinephrine	0-14	matrix metallopeptidase 9	Homo sapiens	120-125
17079456-2	2006	The purpose of this study is to determine if the stress hormone norepi can influence the expression of MMP-2, MMP-9, and VEGF in nasopharyngeal carcinoma (NPC) tumors by using three NPC tumor cell lines.	Norepinephrine	64-70	matrix metallopeptidase 9	Homo sapiens	110-115
16906479-5	2006	Primary adipocytes isolated from PPARgamma agonist-treated rats were also more responsive to noradrenaline stimulation expressed per cell, ruling out a contribution of an altered number of mature adipocytes in explants.	Norepinephrine	93-106	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	33-42
16551834-2	2006	Adrenomedullin (1 nM-0.3 microM) produced concentration-dependent relaxation of endothelium-denuded mesenteric artery rings precontracted with norepinephrine at a concentration required to produce 70% of maximal response (ED70).	Norepinephrine	143-157	adrenomedullin	Rattus norvegicus	0-14
16580633-6	2006	Interestingly, the direction of the emission ratio change of beta(2)AR was opposite to that of the norepinephrine-responsive alpha(2A) adrenergic receptor reported recently.	Norepinephrine	99-113	adrenoceptor beta 2	Homo sapiens	61-70
16154248-3	2006	In addition, all three proteins are required for l-norepinephrine-facilitated iron uptake from transferrin as judged by failure of a fepA iroN cir triple mutant to grow in serum-containing medium in the presence of l-norepinephrine.	Norepinephrine	49-65	transferrin	Mus musculus	95-106
16154248-3	2006	In addition, all three proteins are required for l-norepinephrine-facilitated iron uptake from transferrin as judged by failure of a fepA iroN cir triple mutant to grow in serum-containing medium in the presence of l-norepinephrine.	Norepinephrine	215-231	transferrin	Mus musculus	95-106
16336212-1	2006	We demonstrated previously that membrane depolarization and excitatory receptor agonists such as noradrenaline induce Ca2+-dependent Rho activation in VSM (vascular smooth muscle), resulting in MP (myosin phosphatase) inhibition through the mechanisms involving Rho kinase-mediated phosphorylation of its regulatory subunit MYPT1.	Norepinephrine	97-110	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	324-329
16687308-3	2006	At the beginning of the night, norepinephrine (NE) elicits a rapid and sustained phosphorylation of CREB into pCREB and a transient synthesis of the immediate early gene products c-FOS and c-JUN that peak 3 h after dark onset.	Norepinephrine	31-45	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	179-184
16328376-5	2006	METHODS: CB(1) receptor occupancy was measured using [(3)H] SR141716A, and these occupancies were related to potencies to mediate increases in dopamine (DA) and norepinephrine (NE) release measured with microdialysis and decreases in consumption of a highly palatable diet (HP).	Norepinephrine	161-175	cannabinoid receptor 1	Rattus norvegicus	9-14
16359723-6	2005	Furthermore, as with selective serotonin reuptake inhibitors such as fluvoxamine and paroxetine, SIV was also reduced by the serotonin and noradrenaline reuptake inhibitor milnacipran and the metabotropic glutamate receptor 5 antagonist MPEP, while desipramine was without effect.	Norepinephrine	139-152	glutamate metabotropic receptor 5	Rattus norvegicus	192-225
16285953-2	2005	We tested the hypothesis that pretreatment with JTC-017, a specific corticotropin-releasing hormone receptor 1 antagonist, blocks colorectal distention-induced hippocampal noradrenaline release and visceral perception in rats.	Norepinephrine	172-185	corticotropin releasing hormone receptor 1	Rattus norvegicus	68-110
16285953-12	2005	CONCLUSIONS: Our results suggest that JTC-017, a specific corticotropin-releasing hormone receptor 1 antagonist, attenuates hippocampal noradrenaline release, visceral perception, adrenocorticotropic hormone release, and anxiety after acute colorectal distention in rats.	Norepinephrine	136-149	corticotropin releasing hormone receptor 1	Rattus norvegicus	58-100
16140489-0	2005	Changes in P2Y2 receptor localization on adrenaline- and noradrenaline-containing chromaffin cells in the rat adrenal gland during development and aging.	Norepinephrine	57-70	purinergic receptor P2Y2	Rattus norvegicus	11-15
16140489-4	2005	However, immunoreactivity for adrenaline-containing cells in the P2Y2 receptor-labeled chromaffin cells increased with increasing age and at 1 week post-natal almost all chromaffin cells were positive for both P2Y2 and phenyl ethanolamine-N-methyltransferase, while noradrenaline-containing cells were minimal.	Norepinephrine	266-279	purinergic receptor P2Y2	Rattus norvegicus	65-69
16140489-6	2005	In the aging rat adrenals, P2Y2 receptor-immunoreactivity was localized in subpopulations of both adrenaline and noradrenaline-producing cells.	Norepinephrine	113-126	purinergic receptor P2Y2	Rattus norvegicus	27-31
16039007-1	2005	Alpha1-adrenoreceptors (AR), of which three subtypes exist (alpha1A-, alpha1B- and alpha1D-AR) are G-protein-coupled receptors that mediate the actions of norepinephrine and epinephrine both peripherally and centrally.	Norepinephrine	155-169	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	60-67
16113694-5	2005	However, the CRC maximum responses to NAd in alpha(1D)- and alpha(1BD)-KO mice were significantly lower than those in WT and alpha(1B)-KO mice.	Norepinephrine	38-41	calcium channel, voltage-dependent, N type, alpha 1B subunit	Mus musculus	60-68
16264397-6	2005	RESULTS: BAT strongly inhibited the non-stimulated and norepinephrine - stimulated melatonin secretion from the pig and rat pineal explants, with ED50 0.3 - 0.7 microM.	Norepinephrine	55-69	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	9-12
16264397-9	2005	The half-time of BAT-induced decline in the non - stimulated and norepinephrine-stimulated melatonin secretion was ca.	Norepinephrine	65-79	bile acid CoA:amino acid N-acyltransferase	Rattus norvegicus	17-20
16254819-7	2005	A close relationship was found between affinities obtained for cloned alpha (1A)-AR and inhibitory potencies on noradrenaline-induced contraction or inositol phosphate accumulation in tail artery, confirming that there is a homogeneous functional population of alpha(1A)-AR in this vessel.	Norepinephrine	112-125	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	70-79
16154127-8	2005	In conclusion, neurotensin increases ventricular contractility through stimulation of myocardial norepinephrine release.	Norepinephrine	97-111	neurotensin	Rattus norvegicus	15-26
16026859-5	2005	Norepinephrine and dopamine increased lymphocyte activation accompanied by augmented Th1 and Th2 type cytokine production.	Norepinephrine	0-14	negative elongation factor complex member C/D	Homo sapiens	85-88
16125539-8	2005	During acute hypoglycemia, CRH KO mice maintained higher plasma glucose levels that correlated with higher plasma norepinephrine and greater glycogen mobilization.	Norepinephrine	114-128	corticotropin releasing hormone	Mus musculus	27-30
15939797-0	2005	Norepinephrine induces lipolysis in beta1/beta2/beta3-adrenoceptor knockout mice.	Norepinephrine	0-14	hemoglobin, beta adult minor chain	Mus musculus	42-47
16003188-0	2005	Angiotensin I-converting enzyme-dependent and neutral endopeptidase-dependent generation and degradation of angiotensin II contrarily modulate noradrenaline release: implications for vasopeptidase-inhibitor therapy?	Norepinephrine	143-156	membrane metallo-endopeptidase	Rattus norvegicus	46-67
16217122-3	2005	This rhythm is centered around the transcriptional regulation of the AA-NAT by two norepinephrine-inducible transcription factors, the activator CREB (Ca2+/cAMP-response element binding protein) and the inhibitor ICER (inducible cAMP early repressor).	Norepinephrine	83-97	aralkylamine N-acetyltransferase	Homo sapiens	69-75
16217122-3	2005	This rhythm is centered around the transcriptional regulation of the AA-NAT by two norepinephrine-inducible transcription factors, the activator CREB (Ca2+/cAMP-response element binding protein) and the inhibitor ICER (inducible cAMP early repressor).	Norepinephrine	83-97	cAMP responsive element binding protein 1	Homo sapiens	145-149
16217122-3	2005	This rhythm is centered around the transcriptional regulation of the AA-NAT by two norepinephrine-inducible transcription factors, the activator CREB (Ca2+/cAMP-response element binding protein) and the inhibitor ICER (inducible cAMP early repressor).	Norepinephrine	83-97	cAMP responsive element binding protein 1	Homo sapiens	151-193
16217122-3	2005	This rhythm is centered around the transcriptional regulation of the AA-NAT by two norepinephrine-inducible transcription factors, the activator CREB (Ca2+/cAMP-response element binding protein) and the inhibitor ICER (inducible cAMP early repressor).	Norepinephrine	83-97	cAMP responsive element modulator	Homo sapiens	213-217
16217122-3	2005	This rhythm is centered around the transcriptional regulation of the AA-NAT by two norepinephrine-inducible transcription factors, the activator CREB (Ca2+/cAMP-response element binding protein) and the inhibitor ICER (inducible cAMP early repressor).	Norepinephrine	83-97	cAMP responsive element modulator	Homo sapiens	219-249
15950014-6	2005	In brain regions expressing both the DAT and the norepinephrine transporter (NET), the relative contributions of dopamine and norepinephrine to ADHD pathophysiology and therapeutic response are obfuscated by the capacity of the NET to clear dopamine as well as norepinephrine.	Norepinephrine	126-140	solute carrier family 6 member 3	Homo sapiens	37-40
15705737-1	2005	Cytosolic phospholipase A(2) (cPLA(2)) is activated and translocated to the nuclear envelope by various vasoactive agents, including norepinephrine (NE), and releases arachidonic acid (AA) from tissue phospholipids.	Norepinephrine	133-147	cytosolic phospholipase A2	Oryctolagus cuniculus	0-37
15926928-3	2005	Whereas c-Fos expression was increased in Orx neurons after SD, it was increased in MCH neurons after SR. We reasoned that Orx and MCH neurons could be differently modulated by noradrenaline (NA) and accordingly bear different adrenergic receptors (ARs).	Norepinephrine	177-190	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	8-13
15608072-9	2005	Entrapping the recombinant activated tyrosine kinase pp60(c-Src) strongly potentiated the release of norepinephrine elicited by NMDA/glycine in Mg2+-free medium but failed to permit NMDA receptor activation in presence of external Mg2+ ions.	Norepinephrine	101-115	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	58-63
15677423-5	2004	We show here that sAA activity is increased by acute psychosocial stress (Trier Social Stress Test) and that increases in sAA correlate with increases in norepinephrine.	Norepinephrine	154-168	amylase alpha 1A	Homo sapiens	18-21
15677423-5	2004	We show here that sAA activity is increased by acute psychosocial stress (Trier Social Stress Test) and that increases in sAA correlate with increases in norepinephrine.	Norepinephrine	154-168	amylase alpha 1A	Homo sapiens	122-125
15602689-4	2004	Norepinephrine release mediated by MDMA creates a double-edged sword of heat generation through activation of uncoupling protein (UCP3) along with alpha1- and beta3-adrenoreceptors and loss of heat dissipation through SNS-mediated vasoconstriction.	Norepinephrine	0-14	uncoupling protein 3	Homo sapiens	130-134
15344912-1	2004	In all mammalian species investigated, noradrenaline activates a beta-adrenoceptor/cAMP/protein kinase A-dependent mechanism to switch on arylalkylamine N-acetyltransferase and melatonin biosynthesis in the pineal gland.	Norepinephrine	39-52	aralkylamine N-acetyltransferase	Homo sapiens	138-172
15100092-7	2004	Addition of the sympathetic agonists norepinephrine, isoprenaline, or BRL-37344 (beta(3)-agonist) led to falls in NGF gene expression and secretion by 3T3-L1 adipocytes, as did IL-6 and the PPARgamma agonist rosiglitazone.	Norepinephrine	37-51	nerve growth factor	Mus musculus	114-117
15145612-6	2004	Epinephrine/norepinephrine/isoproterenol/beta 2-AR agonists increased the production of IL-18 in monocytes, but had no effect on IL-12, TNF-alpha, IFN-gamma and IL-10 production.	Norepinephrine	12-26	interleukin 18	Homo sapiens	88-93
15147203-1	2004	The agonist-induced dynamic regulation of the beta(2)-adrenergic receptor (beta(2)-AR) on living cells was examined by means of fluorescence correlation spectroscopy (FCS) using a fluorescence-labeled arterenol derivative (Alexa-NA) in hippocampal neurons and in alveolar epithelial type II cell line A549.	Norepinephrine	201-210	adrenoceptor beta 2	Homo sapiens	75-85
15066288-5	2004	The role of norepinephrine in retrieval requires signaling through the beta(1)-adrenergic receptor in the hippocampus.	Norepinephrine	12-26	adrenergic receptor, beta 1	Mus musculus	71-98
14726440-4	2004	In endothelium-intact arteries, K(+), the thromboxane mimetic U46619, 5-hydroxytryptamine (5-HT), and endothelin-1 (ET-1) induced concentration-dependent contractions, whereas phenylephrine, norepinephrine, and ACTH were without effect.	Norepinephrine	191-205	endothelin 1	Bos taurus	102-114
14726440-4	2004	In endothelium-intact arteries, K(+), the thromboxane mimetic U46619, 5-hydroxytryptamine (5-HT), and endothelin-1 (ET-1) induced concentration-dependent contractions, whereas phenylephrine, norepinephrine, and ACTH were without effect.	Norepinephrine	191-205	endothelin 1	Bos taurus	116-120
14744802-13	2004	Atenolol (beta(1)-adrenoceptor antagonist) blocked the noradrenaline-induced effects, but butoxamine (beta(2)-adrenoceptor antagonist) did not.	Norepinephrine	55-68	adrenergic receptor, beta 1	Mus musculus	10-30
14736546-7	2004	NEFA and insulin concentrations increased early and progressively in DCM in association with increased norepinephrine concentrations and progressive hemodynamic impairment.	Norepinephrine	103-117	insulin	Canis lupus familiaris	9-16
14697247-6	2004	Increases in haptoglobin mRNA level were also induced by dexamethasone, noradrenaline, isoprenaline, and a beta3-adrenoceptor agonist.	Norepinephrine	72-85	haptoglobin	Mus musculus	13-24
15554782-4	2004	One strategy for patients who have not responded to treatment with an SRI is to switch them to a serotonin-norepinephrine reuptake inhibitor, because some patients may respond better to agents that target multiple systems.	Norepinephrine	107-121	sorcin	Homo sapiens	70-73
15545008-9	2004	In the rat brain, the most prominent observation was the revelation of all catecholamine cells (dopamine, norepinephrine, epinephrine) by the flotillin-1 antibody (1:100 dilution).	Norepinephrine	106-120	flotillin 1	Rattus norvegicus	142-153
14642444-13	2003	Phosphorylation of MARCKS has been reported to play an important role in the release of neurotransmitters, such as noradrenaline and serotonin.	Norepinephrine	115-128	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	19-25
14654758-10	2003	At baseline, 24-h urinary excretion of levodopa (L-DOPA), dopamine and noradrenaline was increased by 145, 85 and 74%, respectively, in COMT (-/-) mice compared with wild-type controls.	Norepinephrine	71-84	catechol-O-methyltransferase	Mus musculus	136-140
14561937-3	2003	Neuromedin U administration facilitated noradrenaline release in the supraoptic nucleus.	Norepinephrine	40-53	neuromedin U	Rattus norvegicus	0-12
12837768-4	2003	Of 18 mutations where hNET amino acid residues were exchanged with those of the human dopamine transporter, MrIA had increased potency for inhibition of [3H]norepinephrine uptake for three mutations (in predicted extracellular loops 3 and 4 and transmembrane domain (TMD) 8) and decreased potency for one mutation (in TMD6 and intracellular loop (IL) 3).	Norepinephrine	157-171	solute carrier family 6 member 3	Homo sapiens	86-106
12824451-5	2003	CPT tended to cause a larger increase in mean arterial blood pressure in older men (older (O): 16 +/- 3 mmHg; younger (Y): 10 +/- 2 mmHg) during exercise, but increases in arterial noradrenaline were similar (O: 2.56 +/- 0.96 nM; Y: 1.98 +/- 0.40 nM).	Norepinephrine	181-194	choline phosphotransferase 1	Homo sapiens	0-3
12718440-0	2003	A mutation in the ATP7B copper transporter causes reduced dopamine beta-hydroxylase and norepinephrine in mouse adrenal.	Norepinephrine	88-102	ATPase, Cu++ transporting, beta polypeptide	Mus musculus	18-23
12609747-0	2003	Angiotensin II-induced release of oxytocin: interaction with norepinephrine and role in lactation.	Norepinephrine	61-75	oxytocin/neurophysin I prepropeptide	Homo sapiens	34-42
12609747-8	2003	These data demonstrate that Ang II evoked OT release is mediated through activation of both AT1 and AT2 receptors and suggest that a component of Ang II-induced OT stimulation is due to norepinephrine release.	Norepinephrine	186-200	oxytocin/neurophysin I prepropeptide	Homo sapiens	161-163
12623961-2	2003	Furthermore, local release of atrial natriuretic peptide inhibits norepinephrine release in this nucleus, blocking local activation of alpha2-adrenergic receptors, and thereby contributes to NaCl-sensitive hypertension in spontaneously hypertensive rats.	Norepinephrine	66-80	natriuretic peptide A	Rattus norvegicus	30-56
12538816-6	2003	In the same manner, salbutanol and terbutaline as well as norepinephrine, epinephrine, and isoproterenol regulated the IL-18-induced cytokine production, including IL-12, tumor necrosis factor-alpha or interferon-gamma through the stimulation of beta 2-AR.	Norepinephrine	58-72	adrenoceptor beta 2	Homo sapiens	246-255
12482921-0	2003	CaM kinase IIalpha mediates norepinephrine-induced translocation of cytosolic phospholipase A2 to the nuclear envelope.	Norepinephrine	28-42	cytosolic phospholipase A2	Oryctolagus cuniculus	68-94
12482921-1	2003	Several growth factors, hormones and neurotransmitters, including norepinephrine, increase cellular calcium levels, promoting the translocation of cytosolic phospholipase A(2) to the nuclear envelope.	Norepinephrine	66-80	cytosolic phospholipase A2	Oryctolagus cuniculus	147-174
12482921-2	2003	This study was conducted to investigate the contributions of the calcium-binding protein calmodulin and of calcium-calmodulin-dependent protein kinase II to cytosolic phospholipase A(2) translocation to the nuclear envelope elicited by norepinephrine in rabbit aortic smooth-muscle cells.	Norepinephrine	236-250	calmodulin	Oryctolagus cuniculus	115-125
12482921-2	2003	This study was conducted to investigate the contributions of the calcium-binding protein calmodulin and of calcium-calmodulin-dependent protein kinase II to cytosolic phospholipase A(2) translocation to the nuclear envelope elicited by norepinephrine in rabbit aortic smooth-muscle cells.	Norepinephrine	236-250	cytosolic phospholipase A2	Oryctolagus cuniculus	157-184
12482921-3	2003	Norepinephrine caused cytosolic phospholipase A(2) accumulation around the nuclear envelope as determined from its immunofluorescence; cytosolic phospholipase A(2) translocation was blocked by inhibitors of calmodulin and calcium-calmodulin-dependent protein kinase II or calcium-calmodulin-dependent protein kinase IIalpha antisense oligonucleotide.	Norepinephrine	0-14	cytosolic phospholipase A2	Oryctolagus cuniculus	22-49
12482921-3	2003	Norepinephrine caused cytosolic phospholipase A(2) accumulation around the nuclear envelope as determined from its immunofluorescence; cytosolic phospholipase A(2) translocation was blocked by inhibitors of calmodulin and calcium-calmodulin-dependent protein kinase II or calcium-calmodulin-dependent protein kinase IIalpha antisense oligonucleotide.	Norepinephrine	0-14	calmodulin	Oryctolagus cuniculus	207-217
12482921-3	2003	Norepinephrine caused cytosolic phospholipase A(2) accumulation around the nuclear envelope as determined from its immunofluorescence; cytosolic phospholipase A(2) translocation was blocked by inhibitors of calmodulin and calcium-calmodulin-dependent protein kinase II or calcium-calmodulin-dependent protein kinase IIalpha antisense oligonucleotide.	Norepinephrine	0-14	calmodulin	Oryctolagus cuniculus	230-240
12482921-3	2003	Norepinephrine caused cytosolic phospholipase A(2) accumulation around the nuclear envelope as determined from its immunofluorescence; cytosolic phospholipase A(2) translocation was blocked by inhibitors of calmodulin and calcium-calmodulin-dependent protein kinase II or calcium-calmodulin-dependent protein kinase IIalpha antisense oligonucleotide.	Norepinephrine	0-14	calmodulin	Oryctolagus cuniculus	230-240
12482921-4	2003	Calmodulin and calcium-calmodulin-dependent protein kinase II inhibitors did not prevent cytosolic calcium increase but attenuated cytosolic phospholipase A(2) phosphorylation caused by norepinephrine or ionomycin.	Norepinephrine	186-200	calmodulin	Oryctolagus cuniculus	0-10
12482921-4	2003	Calmodulin and calcium-calmodulin-dependent protein kinase II inhibitors did not prevent cytosolic calcium increase but attenuated cytosolic phospholipase A(2) phosphorylation caused by norepinephrine or ionomycin.	Norepinephrine	186-200	cytosolic phospholipase A2	Oryctolagus cuniculus	131-158
12482921-7	2003	These data suggest that norepinephrine-induced translocation of cytosolic phospholipase A(2) to the nuclear envelope is mediated by its phosphorylation by calcium-calmodulin-dependent protein kinase II and that calcium alone is insufficient for cytosolic phospholipase A(2) translocation to the nuclear envelope in rabbit vascular smooth-muscle cells.	Norepinephrine	24-38	cytosolic phospholipase A2	Oryctolagus cuniculus	64-91
12482921-7	2003	These data suggest that norepinephrine-induced translocation of cytosolic phospholipase A(2) to the nuclear envelope is mediated by its phosphorylation by calcium-calmodulin-dependent protein kinase II and that calcium alone is insufficient for cytosolic phospholipase A(2) translocation to the nuclear envelope in rabbit vascular smooth-muscle cells.	Norepinephrine	24-38	calmodulin	Oryctolagus cuniculus	163-173
12482921-7	2003	These data suggest that norepinephrine-induced translocation of cytosolic phospholipase A(2) to the nuclear envelope is mediated by its phosphorylation by calcium-calmodulin-dependent protein kinase II and that calcium alone is insufficient for cytosolic phospholipase A(2) translocation to the nuclear envelope in rabbit vascular smooth-muscle cells.	Norepinephrine	24-38	cytosolic phospholipase A2	Oryctolagus cuniculus	245-272
12145319-5	2002	The amisyn coil domain prevents the SNAP-25 C-terminally mediated rescue of botulinum neurotoxin E inhibition of norepinephrine exocytosis in permeabilized PC12 cells to a greater extent than it prevents the regular exocytosis of these vesicles.	Norepinephrine	113-127	synaptosome associated protein 25	Rattus norvegicus	36-43
12056750-11	2002	Neuropeptide Y is the dominating peptidergic transmitter in the testicular nerves and colocalized with noradrenaline in the same axons.	Norepinephrine	103-116	pro-neuropeptide Y	Camelus dromedarius	0-14
11853869-5	2002	administration of NMU on mean arterial pressure (MAP), heart rate (HR), and plasma norepinephrine in conscious rats.	Norepinephrine	83-97	neuromedin U	Rattus norvegicus	18-21
11853869-7	2002	In contrast, plasma norepinephrine increased only with a high dose of neuromedin U.	Norepinephrine	20-34	neuromedin U	Rattus norvegicus	70-82
12020731-9	2002	Both sexes generally showed increased in hippocampal (CA3) norepinephrine levels in their respective stress groups.	Norepinephrine	59-73	carbonic anhydrase 3	Rattus norvegicus	54-57
11940765-16	2002	Noradrenaline increased intracellular Ca2+ concentration ([Ca2+]i) concentration-dependently, which was inhibited by ONOO-1 in alpha1a- and alpha1d-adrenoceptors.	Norepinephrine	0-13	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	127-134
11940765-20	2002	Treatment with ONOO-1 attenuates noradrenaline-stimulated increase in [Ca2+]i in alpha1a- and alpha1d-adrenoceptors but not in alpha1b-adrenoceptor.	Norepinephrine	33-46	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	81-88
11940765-21	2002	ONOO-1 also weakens noradrenaline-induced contractions in rat aorta that has alpha1a- and alpha1d-adrenoceptors.	Norepinephrine	20-33	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	77-84
11896172-7	2002	A postmortem examination in GluRepsilon4 mutant mice revealed that tissue contents of norepinephrine, dopamine, serotonin, and their metabolites were reduced in the hippocampus and that dopamine, as well as serotonin, metabolism was upregulated in the frontal cortex, striatum, hippocampus, and thalamus.	Norepinephrine	86-100	glutamate receptor, ionotropic, NMDA2D (epsilon 4)	Mus musculus	28-40
11805341-0	2002	The NK1 receptor mediates both the hyperalgesia and the resistance to morphine in mice lacking noradrenaline.	Norepinephrine	95-108	tachykinin receptor 1	Mus musculus	4-16
11927164-10	2002	The time course of onset of presynaptic inhibition of norepinephrine release was much faster for the alpha(2A)-receptor than for the alpha(2C)-subtype.	Norepinephrine	54-68	adrenergic receptor, alpha 2c	Mus musculus	133-141
11927164-11	2002	After prolonged stimulation with norepinephrine, presynaptic alpha(2C)-adrenergic receptors were desensitized.	Norepinephrine	33-47	adrenergic receptor, alpha 2c	Mus musculus	61-69
12127097-17	2002	Estradiol treatment increased norepinephrine levels in CA3 region of the hippocampus, mitigating stress-dependent changes.	Norepinephrine	30-44	carbonic anhydrase 3	Rattus norvegicus	55-58
12127097-21	2002	In relation to interactions between stress and estradiol on cognition and anxiety, changes in the prefrontal cortex dopaminergic system, dentate gyrus serotonergic system, and norepinephrine levels in the CA3 region appear important.	Norepinephrine	176-190	carbonic anhydrase 3	Rattus norvegicus	205-208
11591725-8	2001	This observation correlated with a higher affinity of norepinephrine at the murine alpha(2C)- than at the alpha(2A)-receptor subtype and may explain why alpha(2C)-adrenergic receptors are especially suited to control sympathetic neurotransmission at low action potential frequencies in contrast to the alpha(2A)-receptor subtype.	Norepinephrine	54-68	adrenergic receptor, alpha 2c	Mus musculus	83-91
11591725-8	2001	This observation correlated with a higher affinity of norepinephrine at the murine alpha(2C)- than at the alpha(2A)-receptor subtype and may explain why alpha(2C)-adrenergic receptors are especially suited to control sympathetic neurotransmission at low action potential frequencies in contrast to the alpha(2A)-receptor subtype.	Norepinephrine	54-68	adrenergic receptor, alpha 2c	Mus musculus	153-161
11742865-2	2001	To investigate the signaling pathways involved in contraction, we studied the activation and regulation of p38 mitogen-activated protein kinases (p38MAPKs) and heat shock protein (HSP) kinase by endothelin and noradrenaline in rat mesenteric arteries.	Norepinephrine	210-223	mitogen-activated protein kinase 11	Rattus norvegicus	146-154
11711043-8	2001	These results suggest that the activation of CRF(1) receptor may play an important role in the elevation of noradrenaline transmission, but not in 5-hydroxytriptamine transmission, in the cerebral cortex, which projects from the locus coeruleus during morphine withdrawal.	Norepinephrine	108-121	corticotropin releasing hormone receptor 1	Mus musculus	45-60
11479288-2	2001	Activation of CaM kinase II in norepinephrine-stimulated vascular smooth muscle cells leads to activation of cPLA(2) and arachidonic acid release.	Norepinephrine	31-45	phospholipase A2 group IVA	Homo sapiens	109-116
11479288-4	2001	Phosphopeptide mapping studies with cPLA(2) from norepinephrine-stimulated smooth muscle cells indicates that phosphorylation of cPLA(2) on Ser-515, but not on Ser-505 or Ser-727, occurs in vivo.	Norepinephrine	49-63	phospholipase A2 group IVA	Homo sapiens	36-43
11479288-4	2001	Phosphopeptide mapping studies with cPLA(2) from norepinephrine-stimulated smooth muscle cells indicates that phosphorylation of cPLA(2) on Ser-515, but not on Ser-505 or Ser-727, occurs in vivo.	Norepinephrine	49-63	phospholipase A2 group IVA	Homo sapiens	129-136
11710758-5	2001	Urinary epinephrine and norepinephrine excretion was significantly higher in the LPD high-sucrose group than in the NPD and LPD low-sucrose groups, and there was a significant positive correlation between urinary norepinephrine excretion and systolic blood pressure.	Norepinephrine	24-38	acyl-CoA synthetase bubblegum family member 1	Rattus norvegicus	81-84
11710758-5	2001	Urinary epinephrine and norepinephrine excretion was significantly higher in the LPD high-sucrose group than in the NPD and LPD low-sucrose groups, and there was a significant positive correlation between urinary norepinephrine excretion and systolic blood pressure.	Norepinephrine	213-227	acyl-CoA synthetase bubblegum family member 1	Rattus norvegicus	81-84
11585676-2	2001	The beta-AR signal system is one of the most powerful regulators of cardiac function, mediated by the effects of the sympathetic transmitters epinephrine and norepinephrine.	Norepinephrine	158-172	adrenergic receptor, beta 1	Mus musculus	4-11
11504796-4	2001	Clozapine (10 microM), a dopamine D(4) receptor antagonist with significant activity at adrenergic receptors, partially attenuated both dopamine and norepinephrine-induced decreases in AVP-stimulated Pf.	Norepinephrine	149-163	dopamine receptor D4	Rattus norvegicus	25-47
11459117-0	2001	Adrenomedullin inhibits the pressor effects and decrease in renal blood flow induced by norepinephrine or angiotensin II in anesthetized rats.	Norepinephrine	88-102	adrenomedullin	Rattus norvegicus	0-14
11390028-3	2001	We have found: ACP-1 inhibited both dopamine and norepinephrine release; ACP-2 inhibited dopamine release, without affecting norepinephrine release; ACP-3 was almost ineffective, except for a weak dopamine inhibiting effect only at a higher concentration.	Norepinephrine	49-63	acid phosphatase 1	Rattus norvegicus	15-20
11426840-3	2001	administered CRF and urocortin (0.5, 1.5 and 3.0 nmol/animal) effectively and dose-dependently elevated plasma levels of adrenaline and noradrenaline, and the effect of urocortin was almost the same as that of CRF.	Norepinephrine	136-149	urocortin	Rattus norvegicus	21-30
11306720-0	2001	Molecular mechanism for agonist-promoted alpha(2A)-adrenoceptor activation by norepinephrine and epinephrine.	Norepinephrine	78-92	adrenoceptor alpha 2A	Homo sapiens	41-63
11306460-6	2001	In summary, norepinephrine-induced locomotion of SW 480 cells is beta2-adrenoceptor mediated and distinct from spontaneous locomotion concerning the PTK involvement.	Norepinephrine	12-26	adrenoceptor beta 2	Homo sapiens	65-83
11171649-4	2001	We observed that ET-1 (8 x 10(-10) M) significantly amplified the concentration-dependent (10(-7)-10(-5) M) skin vasoconstrictor effect of norepinephrine.	Norepinephrine	139-153	endothelin-1	Sus scrofa	17-21
11284440-11	2001	), a reference PAF receptor antagonist, completely prevented the LPS-induced cardiovascular collapse and abolished the sharp reductions of the arterial blood pressure and CO responses to noradrenaline observed during endotoxaemia.	Norepinephrine	187-200	PCNA clamp associated factor	Rattus norvegicus	15-18
11740147-8	2001	CONCLUSIONS: These results reveal that alcohol is able to induce hypertension and provide evidence that alcohol inhibits the transcriptions of both 11beta-HSD2 and CYP11B2 in the vasculature, leading to lower aldosterone and higher corticosterone production in vessels, and increased vasoconstrictor responses to norepinephrine.	Norepinephrine	313-327	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	148-159
11740147-8	2001	CONCLUSIONS: These results reveal that alcohol is able to induce hypertension and provide evidence that alcohol inhibits the transcriptions of both 11beta-HSD2 and CYP11B2 in the vasculature, leading to lower aldosterone and higher corticosterone production in vessels, and increased vasoconstrictor responses to norepinephrine.	Norepinephrine	313-327	cytochrome P450, family 11, subfamily b, polypeptide 2	Rattus norvegicus	164-171
11179598-1	2001	Central administration of bombesin (BN) (into the ventricular system) increased circulating levels of ACTH, corticosterone, epinephrine, norepinephrine and glucose, indicating that this peptide activates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system.	Norepinephrine	137-151	gastrin releasing peptide	Homo sapiens	26-34
11179598-1	2001	Central administration of bombesin (BN) (into the ventricular system) increased circulating levels of ACTH, corticosterone, epinephrine, norepinephrine and glucose, indicating that this peptide activates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system.	Norepinephrine	137-151	gastrin releasing peptide	Homo sapiens	36-38
11150503-5	2000	Western blotting of cytosolic and nuclear protein extracts from cultured differentiated brown adipocytes showed that HO-1 and HO-2 are indeed localized in the cytosol and nuclei of brown adipocytes, and that noradrenaline stimulation significantly increased their amount in cytosol but not in the nuclear fraction.	Norepinephrine	208-221	heme oxygenase 1	Rattus norvegicus	117-130
11269921-3	2000	The effect of exogenous NPY (10 nM) on EFS (8 Hz, 0.3 ms, 12 V, for 1 min)-evoked overflow of noradrenaline (NA) was also studied using an HPLC technique with electrochemical detection.	Norepinephrine	94-107	pro-neuropeptide Y	Cavia porcellus	24-27
11100982-2	2000	We previously demonstrated that atrial natriuretic factor and B- and C-type natriuretic peptides (ANF, BNP, and CNP, respectively) modified catecholamine metabolism by increasing the neuronal uptake and decreasing the neuronal release of norepinephrine in the rat hypothalamus.	Norepinephrine	238-252	natriuretic peptide A	Rattus norvegicus	32-57
11100982-2	2000	We previously demonstrated that atrial natriuretic factor and B- and C-type natriuretic peptides (ANF, BNP, and CNP, respectively) modified catecholamine metabolism by increasing the neuronal uptake and decreasing the neuronal release of norepinephrine in the rat hypothalamus.	Norepinephrine	238-252	natriuretic peptide A	Rattus norvegicus	98-101
11108138-3	2000	The addition of norepinephrine (NE), isoproterenol (a beta1/beta2-adrenergic receptor (AR) agonist) and iodoclonidine (an alpha2-AR agonist) stimulated the expression of the ANG-GH fusion gene in a dose-dependent manner, whereas the addition of epinephrine and phenylephrine (alpha1-AR agonist) had no effect.	Norepinephrine	16-30	adrenoceptor beta 2	Homo sapiens	60-85
10882842-6	2000	These results suggest that clozapine and olanzapine increase noradrenaline release by stimulating noradrenergic neuronal activity in the locus coeruleus and, consequently, increased noradrenaline induce Fos expression in the mPFC via beta-adrenergic receptors.	Norepinephrine	182-195	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	203-206
10940784-1	2000	Human adrenomedullin (AM) and human calcitonin gene-related peptide (CGRP) produced a concentration-dependent relaxation in mouse aorta, precontracted with noradrenaline.	Norepinephrine	156-169	adrenomedullin	Homo sapiens	6-25
10878345-0	2000	Activation of antigen-specific CD4+ Th2 cells and B cells in vivo increases norepinephrine release in the spleen and bone marrow.	Norepinephrine	76-90	CD4 antigen	Mus musculus	31-34
10959006-0	2000	Neuropeptide Y is a cotransmitter with norepinephrine in guinea pig inferior mesenteric vein.	Norepinephrine	39-53	pro-neuropeptide Y	Cavia porcellus	0-14
10959006-1	2000	Neuropeptide Y (NPY) is a cotransmitter with noradrenaline in guinea pig inferior mesenteric vein.	Norepinephrine	45-58	pro-neuropeptide Y	Cavia porcellus	0-14
10959006-1	2000	Neuropeptide Y (NPY) is a cotransmitter with noradrenaline in guinea pig inferior mesenteric vein.	Norepinephrine	45-58	pro-neuropeptide Y	Cavia porcellus	16-19
10959006-5	2000	Norepinephrine and NPY are involved in neuromuscular transmission in guinea pig mesenteric vein suggesting that the sympathetic nervous system requires the coordinated action of norepinephrine and NPY to serve capacitance.	Norepinephrine	0-14	pro-neuropeptide Y	Cavia porcellus	197-200
10959006-5	2000	Norepinephrine and NPY are involved in neuromuscular transmission in guinea pig mesenteric vein suggesting that the sympathetic nervous system requires the coordinated action of norepinephrine and NPY to serve capacitance.	Norepinephrine	178-192	pro-neuropeptide Y	Cavia porcellus	19-22
10827134-9	2000	Surprisingly, norepinephrine activates p38-MAPK via beta-ARs in mouse cardiomyocytes, but beta-AR activation of p38-MAPK alone is not sufficient to induce cardiomyocyte hypertrophy.	Norepinephrine	14-28	adrenergic receptor, beta 1	Mus musculus	52-59
10788502-0	2000	Norepinephrine induces vascular endothelial growth factor gene expression in brown adipocytes through a beta -adrenoreceptor/cAMP/protein kinase A pathway involving Src but independently of Erk1/2.	Norepinephrine	0-14	vascular endothelial growth factor A	Mus musculus	23-57
10788502-2	2000	The endogenous adrenergic neurotransmitter norepinephrine (NE) induced VEGF expression 3-fold, in a dose- and time-dependent manner (EC(50) approximately 90 nm).	Norepinephrine	43-57	vascular endothelial growth factor A	Mus musculus	71-75
10784001-7	2000	NPY and PYY, but not PP, SP, CCK or GIP, inhibited the increase in glucose release by glucagon and noradrenaline.	Norepinephrine	99-112	peptide YY	Rattus norvegicus	8-11
10784001-9	2000	Only portal NPY and PYY enhanced slightly the noradrenaline-dependent reduction of portal flow.	Norepinephrine	46-59	peptide YY	Rattus norvegicus	20-23
10784001-11	2000	NPY and PYY act as signal factors of the absorptive phase function as antagonists of the postabsorptive glucose regulatory hormones glucagon and noradrenaline.	Norepinephrine	145-158	peptide YY	Rattus norvegicus	8-11
10729318-6	2000	In the presence of NPY concentration-response curves for acetylcholine and noradrenaline were significantly shifted to the right and left respectively.	Norepinephrine	75-88	pro-neuropeptide Y	Cavia porcellus	19-22
10729318-8	2000	The receptor reserve (K(A)/EC(50)) for acetylcholine was decreased and for noradrenaline was increased in the presence of NPY, although no changes in the dissociation constants of the neurotransmitter-receptor complexes were observed.	Norepinephrine	75-88	pro-neuropeptide Y	Cavia porcellus	122-125
10698191-5	2000	CRH KO mice had significantly lower plasma epinephrine and higher norepinephrine than WT mice at baseline, and delayed epinephrine secretion during restraint.	Norepinephrine	66-80	corticotropin releasing hormone	Mus musculus	0-3
10762326-2	2000	This rhythm involves the transcriptional regulation of the AANAT by two norepinephrine (NE)-inducible transcription factors, e.g. the activator pCREB (phosphorylated Ca2+/cAMP-response element binding protein) and the inhibitor ICER (inducible cAMP early repressor).	Norepinephrine	72-86	cAMP responsive element modulator	Mus musculus	228-232
10762326-2	2000	This rhythm involves the transcriptional regulation of the AANAT by two norepinephrine (NE)-inducible transcription factors, e.g. the activator pCREB (phosphorylated Ca2+/cAMP-response element binding protein) and the inhibitor ICER (inducible cAMP early repressor).	Norepinephrine	72-86	cAMP responsive element modulator	Mus musculus	234-264
10646533-0	2000	An investigation of noradrenaline uptake and release by the CATH.a cell line.	Norepinephrine	20-33	cathepsin H	Mus musculus	60-64
10629458-8	2000	A small decrease in IFN-gamma production and an increase in IL-10, IL-4, and IL-5 production were also observed with norepinephrine.	Norepinephrine	117-131	interleukin 10	Homo sapiens	60-65
10714892-6	2000	In the functional study, concentration-response curves to noradrenaline pretreated with KMD-3213, an alpha1A/L-adrenoceptor selective antagonist, seemed to be biphasic in nature.	Norepinephrine	58-71	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	101-108
11452226-9	2000	CONCLUSIONS: 1) noradrenaline has significant negative immunoregulatory effects in humans through enhancing the production of IL-10 and suppressing that of IFNgamma; and 2) the suppression of the production of IFNgamma is in part related to alpha2-adrenoceptor activation.	Norepinephrine	16-29	interleukin 10	Homo sapiens	126-131
10717436-9	2000	These results indicate that during acute thalamic hypoxia an increased release of noradrenaline, serotonin, histamine and nitric oxide is responsible for transforming I(h) into an instantaneously activating current via cyclic AMP- and cyclic GMP-mediated mechanisms.	Norepinephrine	82-95	5'-nucleotidase, cytosolic II	Homo sapiens	242-245
11270969-4	1999	Norepinephrine-induced increase of [Ca2+]i was inhibited by the tyrosine kinase inhibitors quercetin and tyrphostin by 23.8% and 21.4%, respectively, but the accumulation of [3H]InsPs induced by norepinephrine was not.	Norepinephrine	195-209	TXK tyrosine kinase	Homo sapiens	64-79
11270969-5	1999	The activity of the plasma-associated tyrosine kinase was increased to (1.73 +/- 0.72)-fold over the control by norepinephrine 10 mumol.L-1.	Norepinephrine	112-126	TXK tyrosine kinase	Homo sapiens	38-53
10555559-1	1999	Noradrenaline-dependent brown adipose tissue (BAT) thermogenesis is activated by the cold and excess energy intake, largely depends on the activity of the uncoupling protein 1 (UCP1), and is mediated mainly through the beta3-adrenoceptor (beta3-AR).	Norepinephrine	0-13	adrenoceptor beta 3	Rattus norvegicus	219-237
10555559-1	1999	Noradrenaline-dependent brown adipose tissue (BAT) thermogenesis is activated by the cold and excess energy intake, largely depends on the activity of the uncoupling protein 1 (UCP1), and is mediated mainly through the beta3-adrenoceptor (beta3-AR).	Norepinephrine	0-13	adrenoceptor beta 3	Rattus norvegicus	239-247
10423355-7	1999	Furthermore, since norepinephrine infusion also increased HO-1 transcript and protein levels, the HO-1 system probably was induced in RHF by the increased interstitial norepinephrine levels known to occur in failing myocardium.	Norepinephrine	19-33	heme oxygenase 1	Canis lupus familiaris	58-62
10423355-7	1999	Furthermore, since norepinephrine infusion also increased HO-1 transcript and protein levels, the HO-1 system probably was induced in RHF by the increased interstitial norepinephrine levels known to occur in failing myocardium.	Norepinephrine	19-33	heme oxygenase 1	Canis lupus familiaris	98-102
10336518-7	1999	Both norepinephrine and dopamine inhibited forskolin-stimulated cAMP accumulation in intact NRK-alpha2C cells.	Norepinephrine	5-19	adrenergic receptor, alpha 2c	Mus musculus	96-103
10336518-10	1999	The endogenous activator of the striatal alpha2C adrenoceptor may be dopamine, as well as norepinephrine.	Norepinephrine	90-104	adrenergic receptor, alpha 2c	Mus musculus	41-61
10360575-5	1999	Mutant ganglionic anlagen also fail to switch on the genes that encode two enzymes needed for the biosynthesis of the neurotransmitter noradrenaline, dopamine-beta-hydroxylase and tyrosine hydroxylase, demonstrating that Phox2b regulates the noradrenergic phenotype in vertebrates.	Norepinephrine	135-148	paired-like homeobox 2b	Mus musculus	221-227
10318661-8	1999	CONCLUSIONS: Evidence that salbutamol increased norepinephrine release from cardiac sympathetic nerves was provided by the observations that atenolol suppressed the salbutamol inotropic response, demonstrating that this response was mediated in part by beta1-receptors and that salbutamol also resulted in an increase in cardiac norepinephrine spillover.	Norepinephrine	48-62	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	253-258
10318661-8	1999	CONCLUSIONS: Evidence that salbutamol increased norepinephrine release from cardiac sympathetic nerves was provided by the observations that atenolol suppressed the salbutamol inotropic response, demonstrating that this response was mediated in part by beta1-receptors and that salbutamol also resulted in an increase in cardiac norepinephrine spillover.	Norepinephrine	329-343	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	253-258
10376271-5	1999	Norepinephrine also elevated [Ca2+]i in a concentration-dependent manner (202 +/- 24% over basal level at 10(-4) mol/L).	Norepinephrine	0-14	carbonic anhydrase 2	Homo sapiens	30-33
10376271-7	1999	The Ca(2+)-channel antagonist nifedipine caused decrease in the [Ca2+]i response to 10(-5) mol/L of norepinephrine by 84%, whereas the [Ca2+]i rise to 10(-5) mol/L cocaine was not significantly changed.	Norepinephrine	100-114	carbonic anhydrase 2	Homo sapiens	65-68
11798659-14	1999	There is evidence that it inhibits the enzymes of both 11beta-HSD2 and CYP11B2 in vasculature and leads to higher corticosterone and lower aldosterone production in vessels as well as an increase in vascular responses to norepinephrine.	Norepinephrine	221-235	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	55-66
11798659-14	1999	There is evidence that it inhibits the enzymes of both 11beta-HSD2 and CYP11B2 in vasculature and leads to higher corticosterone and lower aldosterone production in vessels as well as an increase in vascular responses to norepinephrine.	Norepinephrine	221-235	cytochrome P450, family 11, subfamily b, polypeptide 2	Rattus norvegicus	71-78
10219238-2	1999	Botulinum neurotoxin E inhibition of norepinephrine release in permeabilized PC12 cells can be rescued by adding a 65 aa C-terminal fragment of SNAP-25 (S25-C).	Norepinephrine	37-51	synaptosome associated protein 25	Rattus norvegicus	144-151
10435003-7	1999	Noradrenaline (NA, 1 microM) was used to stimulate beta 1-AR and isoprenaline (ISO, 1 microM) in the presence of the beta 1-AR antagonist CGP 20712A (0.1 microM) to stimulate beta 2-AR.	Norepinephrine	0-13	adrenoceptor beta 2	Homo sapiens	175-184
10081906-5	1999	The affinity profile of these antagonists suggested that the noradrenaline-induced contractions in the human prostate and the mesenteric artery were mediated by the alpha1L-AR and alpha1B-AR, respectively.	Norepinephrine	61-74	adrenoceptor alpha 1B	Homo sapiens	180-190
10067839-9	1999	These findings suggest that histamine induces systemic and intranuclear OT release by stimulating the release of norepinephrine.	Norepinephrine	113-127	oxytocin/neurophysin I prepropeptide	Homo sapiens	72-74
10076858-2	1999	This study examines the influence of selective 5-HT, as well as norepinephrine, receptor antagonists on the stress-induced down-regulation of BDNF mRNA.	Norepinephrine	64-78	brain-derived neurotrophic factor	Rattus norvegicus	142-146
10474021-10	1999	These results confirm that glycyrrhizin is able to induce hypertension, and provide evidence that it inhibits the transcriptions of both 11beta-HSD2 and CYP11B2 in the vasculature, leading to lower aldosterone and higher corticosterone production in vessels, and increased vasoconstrictor responses to norepinephrine.	Norepinephrine	302-316	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	137-148
10474021-10	1999	These results confirm that glycyrrhizin is able to induce hypertension, and provide evidence that it inhibits the transcriptions of both 11beta-HSD2 and CYP11B2 in the vasculature, leading to lower aldosterone and higher corticosterone production in vessels, and increased vasoconstrictor responses to norepinephrine.	Norepinephrine	302-316	cytochrome P450, family 11, subfamily b, polypeptide 2	Rattus norvegicus	153-160
10465447-5	1999	Herein, using in situ hybridization histochemistry, we show that Nurr1 is expressed only in subset of catecholamine producing neurons (A2 partly, A8-A10 and A11 catecholaminergic cell groups), and is excluded from the norepinephrine producing neurons (A1, A2, A5-A6 catecholaminergic cell groups).	Norepinephrine	218-232	nuclear receptor subfamily 4 group A member 2	Homo sapiens	65-70
9949305-11	1999	The activation of SNAT may be due to a stimulation of the sympathetic nervous system (urinary noradrenaline; NA: +243%, p &lt; 0.005) when the cellular immune system responded towards tumor growth (urinary biopterin, +214%, p &lt; 0.005).	Norepinephrine	94-107	aralkylamine N-acetyltransferase	Homo sapiens	18-22
10052667-3	1998	The noradrenaline infusion increased the unstimulated, the interleukin-2 and interferon-alpha stimulated NK cell activity, and the percentage of CD16+ cells.	Norepinephrine	4-17	Fc gamma receptor IIIa	Homo sapiens	145-149
9763629-4	1998	Application of the adrenocorticotropin (ACTH) secretagogue noradrenaline (NA; norepinephrine), triggered [Ca2+]i oscillation in corticotrophs via alpha-adrenergic receptors and the guanosine trisphosphate (GTP) binding protein-coupled phosphoinositide pathway.	Norepinephrine	59-72	RAS like proto-oncogene B	Rattus norvegicus	181-226
9763629-4	1998	Application of the adrenocorticotropin (ACTH) secretagogue noradrenaline (NA; norepinephrine), triggered [Ca2+]i oscillation in corticotrophs via alpha-adrenergic receptors and the guanosine trisphosphate (GTP) binding protein-coupled phosphoinositide pathway.	Norepinephrine	78-92	RAS like proto-oncogene B	Rattus norvegicus	181-226
9756528-3	1998	Plasma epinephrine (Epi) and norepinephrine (NE) increased markedly in a dose-dependent manner for up to 120 min after intracerebroventricular or intravenous administration of aFGF (6-667 fmol/rat).	Norepinephrine	29-43	fibroblast growth factor 1	Rattus norvegicus	176-180
9826063-0	1998	Nociceptin inhibits noradrenaline release in the mouse brain cortex via presynaptic ORL1 receptors.	Norepinephrine	20-33	opioid receptor-like 1	Mus musculus	84-88
9760026-10	1998	Moreover, the results show that, besides its sympatho-inhibitory effect, losartan can exert a sympatho-excitatory action as shown by the increase in the plasma levels of both noradrenaline and its coneurotransmitter, neuropeptide Y.	Norepinephrine	175-188	neuropeptide Y	Canis lupus familiaris	217-231
9707197-7	1998	The plasma noradrenaline concentration during period 2 was higher in patients with hyponatremia than in those with normonatremia (P &lt; 0.05), whereas the plasma concentrations of ADH and ANP during period 2 were not statistically different between the hyponatremic and normonatremic patients.	Norepinephrine	11-24	period circadian regulator 2	Homo sapiens	46-54
9659456-1	1998	OBJECTIVES: The aims of this study were to determine (1) whether neonatal rat cardiac fibroblasts (CAFB) express P2Y receptors; (2) whether CAFB respond to extracellular ATP by inducing expression of c-fos mRNA; and (3) whether extracellular ATP modulates norepinephrine (NE)-stimulated cell growth in CAFB.	Norepinephrine	256-270	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	200-205
9466976-0	1998	Nitric oxide, atrial natriuretic peptide, and cyclic GMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts.	Norepinephrine	97-111	5'-nucleotidase, cytosolic II	Homo sapiens	53-56
9548402-1	1998	Role of protein kinase C. Noradrenaline increased the mRNA levels of c-fos and c-jun in rat-1 fibroblast lines stably expressing the cloned alpha1-adrenoceptor subtypes.	Norepinephrine	26-39	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	69-74
9585117-4	1998	The alpha1B-adrenoceptor subtype may be located on a space more proximal to the sympathetic nerve endings than the alpha1A-adrenoceptor subtype, because the positive inotropic effect of endogenous norepinephrine was mediated entirely by the alpha1B-adrenoceptor subtype.	Norepinephrine	197-211	adrenoceptor alpha 1B	Homo sapiens	4-24
9585117-4	1998	The alpha1B-adrenoceptor subtype may be located on a space more proximal to the sympathetic nerve endings than the alpha1A-adrenoceptor subtype, because the positive inotropic effect of endogenous norepinephrine was mediated entirely by the alpha1B-adrenoceptor subtype.	Norepinephrine	197-211	adrenoceptor alpha 1B	Homo sapiens	241-261
9825471-2	1998	For the first time discovered universal action of diets with PUFA omega-3 vegetable and animal origin on parameters of humoral immunity: in case of primary excess of norm of the contents of natural antibodies to adrenaline, noradrenaline and dopamine as a result of treatment these parameters were reduced or did not change; and at is primary a low their level--parameters increased in most cases.	Norepinephrine	224-237	pumilio RNA binding family member 3	Homo sapiens	61-65
11938962-2	1998	The results indicate that NGF dose-dependently increased norepinephrine content in mouse submandibular gland and cell numbers of C7 (seventh cervical vertebra), T1 (first thoracic vertebra) dorsal root ganglion in rabbits, and also dramatically promoted the growth of neuronal projections in cultured DRG.	Norepinephrine	57-71	nerve growth factor	Mus musculus	26-29
9395518-7	1997	The magnitude of Cig30 mRNA induction in the cold could be mimicked by chronic norepinephrine treatment in vivo.	Norepinephrine	79-93	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3	Mus musculus	17-22
9395518-8	1997	However, in primary cultures of brown adipocytes, a synergistic action of norepinephrine and dexamethasone was required for full expression of the gene, indicating that both catecholamines and glucocorticoids are required for the induction of Cig30.	Norepinephrine	74-88	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3	Mus musculus	243-248
9428976-8	1997	The inhibition of K+ (IC50 0.5 mumol/l)- and noradrenaline (IC50 1.3 mumol/l)-induced contractions of rabbit aorta rings was in the same concentration range as found for the calmodulin inhibitory activity.	Norepinephrine	45-58	calmodulin	Oryctolagus cuniculus	174-184
9325342-4	1997	Both [125I]AZIK and [125I]TBZ-AIPP photoaffinity labeling of purified rVMAT2 were protectable by 10 microM tetrabenazine (TBZ), 10 microM 7-aminoketanserin, and 1 mM concentrations of the transporter substrates dopamine, norepinephrine, and serotonin.	Norepinephrine	221-235	solute carrier family 18 member A2	Rattus norvegicus	70-76
9387858-1	1997	The principal brain vesicular monoamine transporter (VMAT2) pumps monoamines including dopamine, norepinephrine, serotonin and histamine from neuronal cytoplasm into synaptic vesicles and is implicated in actions of certain psychostimulants and selective neurotoxins.	Norepinephrine	97-111	solute carrier family 18 (vesicular monoamine), member 2	Mus musculus	53-58
9299509-0	1997	Atrial natriuretic factor modifies the biosynthesis and turnover of norepinephrine in the rat adrenal medulla.	Norepinephrine	68-82	natriuretic peptide A	Rattus norvegicus	0-25
9299509-1	1997	In the present work we investigate atrial natriuretic factor (ANF) effects on the endogenous content, utilization and turn over of norepinephrine (NE), on tyrosine hydroxilase (TH) activity, on cAMP and cGMP levels, and on phosphatidylinositol hydrolysis in rat adrenal medulla in order to assess the possible mechanisms underlying ANF effects on NE metabolism.	Norepinephrine	131-145	natriuretic peptide A	Rattus norvegicus	35-60
9299509-1	1997	In the present work we investigate atrial natriuretic factor (ANF) effects on the endogenous content, utilization and turn over of norepinephrine (NE), on tyrosine hydroxilase (TH) activity, on cAMP and cGMP levels, and on phosphatidylinositol hydrolysis in rat adrenal medulla in order to assess the possible mechanisms underlying ANF effects on NE metabolism.	Norepinephrine	131-145	natriuretic peptide A	Rattus norvegicus	62-65
9323082-5	1997	Norepinephrine infusion (2.8 mg x kg(-1) x d(-1)) produced a degree of hypertension and degree of HO-1 mRNA upregulation similar to those of Ang II infusion, which was again blocked by treatment with hydralazine (382+/-18% and 150+/-30% of the control level, respectively).	Norepinephrine	0-14	heme oxygenase 1	Rattus norvegicus	98-102
9313925-2	1997	In this study we have compared the abilities of the enantiomers of the structural isomers of the phenolamines, octopamine and synephrine, and the catecholamines, noradrenaline and adrenaline, to couple selectively a human cloned alpha 2A-adrenoceptor, stably expressed in a Chinese hamster ovary (CHO) cell line, to G-protein linked second messenger pathways mediating an increase and a decrease in cyclic AMP production.	Norepinephrine	162-175	adrenoceptor alpha 2A	Homo sapiens	229-250
9277558-10	1997	Norepinephrine-induced constrictions were potentiated in the ET-1-injected group.	Norepinephrine	0-14	endothelin-1	Sus scrofa	61-65
9487014-2	1997	Enzymes in this biosynthetic pathway, as well as those involved in the synthesis of the essential co-factor (6R)L-erythro-5,6,7,8-tetrahydrobiopterin (6-BH4) are expressed in keratinocytes producing the important hormones norepinephrine and epinephrine, which control a high beta 2-adrenoceptor density on undifferentiated/proliferating keratinocytes and the expression of alpha 1-adrenoceptors on melanocytes.	Norepinephrine	222-236	adrenoceptor beta 2	Homo sapiens	275-294
9239760-5	1997	No evidence shows UTP as a synaptic transmitter; sympathetic neurons may, however, carry P2UR allowing UTP-stimulation of norepinephrine release.	Norepinephrine	122-136	purinergic receptor P2Y2	Homo sapiens	89-93
9226409-6	1997	These data suggest that after extensive blockade of beta-adrenoceptors the positive inotropic effects of phenylephrine and exogenous noradrenaline result from stimulation of the alpha1A- and alpha1B-adrenoceptor subtypes, whereas that of endogenous noradrenaline is mediated via the alpha1B-adrenoceptor subtype.	Norepinephrine	133-146	alpha-1B adrenergic receptor	Oryctolagus cuniculus	191-211
9226409-6	1997	These data suggest that after extensive blockade of beta-adrenoceptors the positive inotropic effects of phenylephrine and exogenous noradrenaline result from stimulation of the alpha1A- and alpha1B-adrenoceptor subtypes, whereas that of endogenous noradrenaline is mediated via the alpha1B-adrenoceptor subtype.	Norepinephrine	133-146	alpha-1B adrenergic receptor	Oryctolagus cuniculus	283-303
9218684-6	1997	The results suggest that only alpha1A-adrenoceptors mediate the noradrenaline-induced vasopressor response in perfused rat hind limb.	Norepinephrine	64-77	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	30-37
9276148-1	1997	We have previously reported that neuropeptide Y (NPY) inhibits responses induced by various agonists (noradrenaline, vasoactive intestinal peptide, substance P,5-hydroxytryptamine) in isolated guinea pig trachea.	Norepinephrine	102-115	pro-neuropeptide Y	Cavia porcellus	33-47
9276148-1	1997	We have previously reported that neuropeptide Y (NPY) inhibits responses induced by various agonists (noradrenaline, vasoactive intestinal peptide, substance P,5-hydroxytryptamine) in isolated guinea pig trachea.	Norepinephrine	102-115	pro-neuropeptide Y	Cavia porcellus	49-52
9205950-6	1997	Furthermore, both beta 1 and beta 2-adrenoceptors can mediate experimental arrhythmias in human cardiac preparations elicited by noradrenaline and adrenaline.	Norepinephrine	129-142	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	18-24
9092590-1	1997	Chemical signaling by dopamine (DA) and L-norepinephrine (L-NE) at synapses is terminated by uptake via specialized presynaptic transport proteins encoded by the DA transporter (DAT) and L-NE transporter (NET) genes, respectively.	Norepinephrine	40-56	solute carrier family 6 member 3	Homo sapiens	178-181
9092590-1	1997	Chemical signaling by dopamine (DA) and L-norepinephrine (L-NE) at synapses is terminated by uptake via specialized presynaptic transport proteins encoded by the DA transporter (DAT) and L-NE transporter (NET) genes, respectively.	Norepinephrine	58-62	solute carrier family 6 member 3	Homo sapiens	178-181
9131288-2	1997	Neuropeptide Y (NPY; 3-100 nmol/L) caused a concentration-dependent potentiation of constriction in response to noradrenaline or the thromboxane mimetic U46619 in arterioles from the submucosa of the guinea-pig small intestine.	Norepinephrine	112-125	pro-neuropeptide Y	Cavia porcellus	0-14
9131288-2	1997	Neuropeptide Y (NPY; 3-100 nmol/L) caused a concentration-dependent potentiation of constriction in response to noradrenaline or the thromboxane mimetic U46619 in arterioles from the submucosa of the guinea-pig small intestine.	Norepinephrine	112-125	pro-neuropeptide Y	Cavia porcellus	16-19
9054470-2	1997	GAL is colocalized with corticotropin (ACTH) in the human pituitary and with epinephrine (E) and norepinephrine (NE) in chromaffin cells of the adrenal medulla.	Norepinephrine	97-111	galanin and GMAP prepropeptide	Homo sapiens	0-3
9034904-14	1997	The rapid induction of Fos in the piriform cortex and the locus coeruleus, taken together with previous anatomical, eletrophysiological and neurochemical studies, suggests that prolonged, excessive exposure to synaptically released acetylcholine and norepinephrine triggers the production of soman-induced seizures initially in the piriform cortex and subsequently in other cortical and subcortical structures.	Norepinephrine	250-264	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	23-26
9046014-1	1997	In vivo effects of single and repeated interferon-alpha administrations on the dynamics of noradrenaline, dopamine and 5-hydroxytryptamine were investigated in the mouse brain.	Norepinephrine	91-104	interferon alpha	Mus musculus	39-55
9076657-6	1997	These results suggest that NMDA receptor antagonists inhibit the increase in protein kinase activity produced by chronic morphine treatment, thus suppressing the naloxone-induced rise in norepinephrine release.	Norepinephrine	187-201	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	77-91
9039106-0	1997	Afferent and efferent arteriolar vasoconstriction to angiotensin II and norepinephrine involves release of Ca2+ from intracellular stores.	Norepinephrine	72-86	carbonic anhydrase 2	Homo sapiens	107-110
9039140-14	1997	The afferent arteriolar response to norepinephrine was enhanced in renal-denervated, Ang II-infused, and Ang II-infused+renal-denervated rats compared with sham controls.	Norepinephrine	36-50	angiogenin	Rattus norvegicus	85-88
8987147-3	1997	Here we present evidence that noradrenaline is released by exocytosis exclusively from the large dense cored vesicles, in which it is stored together with neuropeptide Y.	Norepinephrine	30-43	neuropeptide Y	Canis lupus familiaris	155-169
9066089-3	1997	Recent investigations have demonstrated the presence of several subtypes of alpha 1-adrenoceptors (alpha(1A), alpha(1B), and alpha(1D)) in the human corpus cavernosum and also that the noradrenaline-induced contraction in this tissue is probably mediated by two or, possibly, three receptor subtypes.	Norepinephrine	185-198	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	99-107
11243211-6	1997	This suggests that the inhibitory effects of Ber on norepinephrine, K(+)-, and H2O2-induced [Ca2+]i elevation may be one of the mechanisms against cerebral ischemia.	Norepinephrine	52-66	carbonic anhydrase 2	Homo sapiens	93-96
9035611-14	1996	Norepinephrine induced translocation of PKC-alpha, -beta I, -beta II, -gamma, -delta, and -epsilon isoforms but not -zeta and -eta from cytosol to membrane.	Norepinephrine	0-14	protein kinase C, alpha	Rattus norvegicus	40-49
8921799-12	1996	Norepinephrine plasmatic levels increased in both groups during CPT and exercise.	Norepinephrine	0-14	choline phosphotransferase 1	Homo sapiens	64-67
8947470-2	1996	The basal level of inositol phosphate generation in cells expressing the CAM alpha 1B-adrenergic receptor was greater than for the wild-type receptor, The addition of maximally effective concentrations of phenylephrine or noradrenaline resulted in substantially greater levels of inositol phosphate generation by the CAM alpha 1B-adrenergic receptor, although this receptor was expressed at lower steady-state levels than the wild-type receptor.	Norepinephrine	222-235	adrenoceptor alpha 1B	Homo sapiens	77-105
8947470-2	1996	The basal level of inositol phosphate generation in cells expressing the CAM alpha 1B-adrenergic receptor was greater than for the wild-type receptor, The addition of maximally effective concentrations of phenylephrine or noradrenaline resulted in substantially greater levels of inositol phosphate generation by the CAM alpha 1B-adrenergic receptor, although this receptor was expressed at lower steady-state levels than the wild-type receptor.	Norepinephrine	222-235	adrenoceptor alpha 1B	Homo sapiens	321-349
8903325-8	1996	These data support the hypothesis that local ANP inhibits noradrenaline release in the AHA and thereby contributes to NaCl-sensitive hypertension in SHR.	Norepinephrine	58-71	natriuretic peptide A	Rattus norvegicus	45-48
8982139-5	1996	A 0.1 ml bolus injection of 10(-5) M adrenomedullin decreased the baseline perfusion pressure in a dose-dependent manner for a duration of 20 minutes and also attenuated the pressor response to exogenous norepinephrine injection for at least 10 minutes compared with the control study (p &lt; 0.05) in the absence of vascular endothelium.	Norepinephrine	204-218	adrenomedullin	Homo sapiens	37-51
8982139-7	1996	In addition, the attenuation effect of human adrenomedullin on pressor responses to exogenous norepinephrine injection is independent of vascular endothelium.	Norepinephrine	94-108	adrenomedullin	Homo sapiens	45-59
8930844-5	1996	morphine infusion) alters the responsiveness of oxytocin neurones to systemic cholecystokinin (CCK), a stimulus which activates oxytocin neurones via the release of noradrenaline.	Norepinephrine	165-178	cholecystokinin	Rattus norvegicus	78-93
8930844-5	1996	morphine infusion) alters the responsiveness of oxytocin neurones to systemic cholecystokinin (CCK), a stimulus which activates oxytocin neurones via the release of noradrenaline.	Norepinephrine	165-178	cholecystokinin	Rattus norvegicus	95-98
8930940-0	1996	Acute administration of human galanin in normal subjects reduces the potentiating effect of pyridostigmine-induced cholinergic enhancement on release of norepinephrine and pancreatic polypeptide.	Norepinephrine	153-167	galanin and GMAP prepropeptide	Homo sapiens	30-37
8930940-2	1996	Recently we have reported that human GAL (hGAL) in man depresses the release of norepinephrine (NE) and the responses to both assumption of upright posture and insulin-induced hypoglycemia.	Norepinephrine	80-94	galanin and GMAP prepropeptide	Homo sapiens	37-40
8930940-2	1996	Recently we have reported that human GAL (hGAL) in man depresses the release of norepinephrine (NE) and the responses to both assumption of upright posture and insulin-induced hypoglycemia.	Norepinephrine	80-94	galanin and GMAP prepropeptide	Homo sapiens	42-46
8905332-6	1996	Neuropeptide Y (up to 10(-4) M) did not contract any vessel; however, at 3 x 10(-7) M it shifted the frequency-response and concentration-response curves to noradrenaline in the arteries only.	Norepinephrine	157-170	neuropeptide Y	Canis lupus familiaris	0-14
8888009-0	1996	Inhibition of neuronal nitric oxide synthase potentiates the dimethylphenylpiperazinium-evoked carrier-mediated release of noradrenaline from rat hippocampal slices.	Norepinephrine	123-136	nitric oxide synthase 1	Rattus norvegicus	14-44
8842578-3	1996	The regressions of salivary alpha-amylase on plasma norepinephrine (NE) concentrations were significant for both exercise (P &lt; 0.001) and examination (P &lt; 0.01) protocols.	Norepinephrine	52-66	amylase alpha 1A	Homo sapiens	19-41
8666149-5	1996	Insulin-induced hypoglycemia (plasma glucose = 1.9 +/- 0.1 mmol/l) activated parasympathetic nerves to the pancreas as assessed by increased plasma pancreatic polypeptide (PP) levels (delta = 135.0 +/- 36.8 pmol/l, P &lt; 0.01), produced sympathoadrenal activation as assessed by elevations of plasma epinephrine (EPI) (delta = 22.3 +/- 2.95 nmol/l, P &lt; 0.0005) and norepinephrine (NE) (delta = 3.72 +/- 0.77 mmol/l, P &lt; 0.0025) and increased plasma immunoreactive glucagon (IRG) (delta = 920 +/- 294 ng/l, P &lt; 0.025).	Norepinephrine	369-383	insulin	Canis lupus familiaris	0-7
8640984-12	1996	Bosentan attenuated norepinephrine-induced increases in ventricular weight, ratio of RNA to protein, and expression of skeletal alpha-actin mRNA and beta-myosin heavy chain mRNA at 5 days, but it did not attenuate increased ventricular expression of atrial natriuretic factor mRNA.	Norepinephrine	20-34	natriuretic peptide A	Rattus norvegicus	250-275
8667208-3	1996	In dopamine transporter expressing cells, the maximal transport rate (Vmax) of MPP+, dopamine and noradrenaline was the same, but in noradrenaline transporter expressing cells the Vmax of MPP+ and dopamine was only one-half of the Vmax of noradrenaline.	Norepinephrine	98-111	solute carrier family 6 member 3	Homo sapiens	3-23
8829205-0	1996	Enhancement of brain noradrenaline and dopamine turnover by thyrotropin-releasing hormone and its analogue NS-3 in mice and rats.	Norepinephrine	21-34	thyrotropin releasing hormone	Mus musculus	60-89
8790927-1	1996	In addition to its direct vasoconstrictive effect, neuropeptide Y (NPY) potentiates noradrenaline-(NA) induced contraction and inhibits acetylcholine-(ACh) induced relaxation: The aim of the present study was to elucidate the NPY receptor subtypes responsible for mediating these three responses.	Norepinephrine	84-97	pro-neuropeptide Y	Cavia porcellus	51-65
8790927-1	1996	In addition to its direct vasoconstrictive effect, neuropeptide Y (NPY) potentiates noradrenaline-(NA) induced contraction and inhibits acetylcholine-(ACh) induced relaxation: The aim of the present study was to elucidate the NPY receptor subtypes responsible for mediating these three responses.	Norepinephrine	84-97	pro-neuropeptide Y	Cavia porcellus	67-70
8627568-8	1996	blocked the suppressant effect of microiontophoretically applied norepinephrine (NE) on the firing activity of CA3 dorsal hippocampus pyramidal neurons, indicating their antagonistic effects on postsynaptic alpha-2 adrenoceptors.	Norepinephrine	65-79	carbonic anhydrase 3	Rattus norvegicus	111-114
8792338-6	1996	The overall distribution of neurons expressing GTP cyclohydrolase I mRNA was observed to correspond exactly to the known distribution of the dopamine, norepinephrine/epinephrine and serotonin-containing cell groups.	Norepinephrine	151-165	GTP cyclohydrolase 1	Rattus norvegicus	47-67
8795072-3	1996	Adrenomedullin-like immunoreactivity occurred in noradrenaline- and adrenaline-producing cells in the adrenal gland.	Norepinephrine	49-62	adrenomedullin	Rattus norvegicus	0-14
8626551-5	1996	In human heart, AUF1 mRNA and protein was significantly increased in individuals with myocardial failure, a condition associated with increases in the beta-adrenergic receptor agonist norepinephrine.	Norepinephrine	184-198	heterogeneous nuclear ribonucleoprotein D	Homo sapiens	16-20
8740147-9	1996	When MAO-B was also inhibited, 10 nmol/l amezinium caused 84% inhibition of the deamination of noradrenaline by MAO-A in the lungs.	Norepinephrine	95-108	monoamine oxidase B	Rattus norvegicus	5-10
8670061-12	1996	These results suggest that the mechanism by which noradrenaline stimulates glucose transport into brown adipocytes is not due to translocation of GLUT but is probably due to an increase in the intrinsic activity of GLUT, which is mediated by a cyclic AMP-dependent pathway.	Norepinephrine	50-63	solute carrier family 2 member 1	Homo sapiens	215-219
8678123-1	1996	The monoamine oxidases (MAO-A and MAO-B) are the enzymes primarily responsible for the degradation of amine neurotransmitters, such as dopamine, norepinephrine, and serotonin.	Norepinephrine	145-159	monoamine oxidase B	Homo sapiens	34-39
8549185-13	1996	Norepinephrine exhibits significant effects on the beta-receptors on lymphocytes, suggesting beta 2-adrenoceptor effects with high concentrations of this drug.	Norepinephrine	0-14	adrenoceptor beta 2	Homo sapiens	93-112
8598500-8	1996	These data demonstrate that adrenaline and noradrenaline modulate the migratory capacity of human NK cells via spleen-independent beta 2-adrenoceptor mechanism.	Norepinephrine	43-56	adrenoceptor beta 2	Homo sapiens	130-149
7594065-14	1995	There was a significant correlation between plasma levels of adrenomedullin and norepinephrine (r = 0.618, p &lt; 0.001), atrial natriuretic peptide (r = 0.696, p &lt; 0.001) and brain natriuretic peptide (r = 0.692, p &lt; 0.001).	Norepinephrine	80-94	adrenomedullin	Homo sapiens	61-75
7503321-4	1995	Intravenous administration of human adrenomedullin (10, 100, 1,000, and 3,000 pmol/kg, n = 6) caused a dose-dependent reduction in mean arterial pressure (0 +/- 2, -1 +/- 2, -19 +/- 2, and -29 +/- 4 mmHg, respectively) concomitant with increases in heart rate, renal sympathetic nerve activity, plasma renin activity, and plasma norepinephrine.	Norepinephrine	329-343	adrenomedullin	Homo sapiens	36-50
7487925-3	1995	In contrast to white fat, the level of lipoprotein lipase mRNA in brown adipose tissue was increased by noradrenaline and isoprenaline.	Norepinephrine	104-117	lipoprotein lipase	Mus musculus	39-57
8633189-7	1995	The CD4/CD8 ratio and plasma norepinephrine were positively correlated (rs = 0.57, p = 0.037) and the major part of this correlation was due to a correlation between plasma norepinephrine and the percentage of CD4+ cells.	Norepinephrine	173-187	CD8a molecule	Homo sapiens	8-11
7498270-1	1995	The role of nitric oxide and cyclo-oxygenase products in the platelet-activating factor (PAF)-induced hyporesponsiveness to noradrenaline was investigated in pithed rats.	Norepinephrine	124-137	PCNA clamp associated factor	Rattus norvegicus	61-87
7498270-1	1995	The role of nitric oxide and cyclo-oxygenase products in the platelet-activating factor (PAF)-induced hyporesponsiveness to noradrenaline was investigated in pithed rats.	Norepinephrine	124-137	PCNA clamp associated factor	Rattus norvegicus	89-92
7498270-2	1995	Infusion of PAF (30 ng/kg/min) for 60 min reduced the mean arterial blood pressure and impaired the pressor responses to noradrenaline (10 ng/kg, 100 ng/kg, 1 microgram/kg).	Norepinephrine	121-134	PCNA clamp associated factor	Rattus norvegicus	12-15
7498270-7	1995	These results suggest that nitric oxide contributes to the PAF-induced hyporesponsiveness to noradrenaline and that cyclo-oxygenase products do not play a major role in this hyporesponsiveness.	Norepinephrine	93-106	PCNA clamp associated factor	Rattus norvegicus	59-62
7669062-1	1995	Acute injection of either noradrenaline or isoprenaline in mice activated both brown (BAT) and white (WAT) adipose tissue hormone-sensitive lipase activity (HSL).	Norepinephrine	26-39	lipase, hormone sensitive	Mus musculus	157-160
7653623-0	1995	Effects of PKC downregulation on norepinephrine- and prostaglandin F2 alpha-induced contraction in rat aorta.	Norepinephrine	33-47	protein kinase C, gamma	Rattus norvegicus	11-14
7651358-4	1995	KMD-3213 inhibited norepinephrine-induced increases in intracellular Ca2+ concentrations in alpha 1a-AR-expressing Chinese hamster ovary cells with an IC50 of 0.32 nM but had a much weaker inhibitory effect on the alpha 1b- and alpha 1d-ARs.	Norepinephrine	19-33	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	92-100
8548177-0	1995	Noradrenaline contractions of human prostate mediated by alpha 1A-(alpha 1c-) adrenoceptor subtype.	Norepinephrine	0-13	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	57-90
7539818-0	1995	Human galanin reduces plasma norepinephrine levels in man.	Norepinephrine	29-43	galanin and GMAP prepropeptide	Homo sapiens	6-13
7623082-12	1995	Norepinephrine (&lt; 0.5 mM) applied either to the injury site or the DRG increased the SA of most C fibers and A delta-fibers but only a minority of A beta-fibers in previously injured nerves.	Norepinephrine	0-14	amyloid beta precursor protein	Rattus norvegicus	150-156
7601207-8	1995	Neuropeptide Y inhibits acetylcholine release due to the noradrenaline release mediated by stimulation of a receptor distinct from neuropeptide Y Y1 and Y2 receptors, located on adrenergic neurons.	Norepinephrine	57-70	pro-neuropeptide Y	Cavia porcellus	0-14
8574778-1	1995	Atrial natriuretic factor (ANF) effects on neuronal norepinephrine (NE) release evoked by angiotensin II (ANG II) or angiotensin III (ANG III) were studied in the rat adrenal medulla.	Norepinephrine	52-66	natriuretic peptide A	Rattus norvegicus	0-25
8574778-1	1995	Atrial natriuretic factor (ANF) effects on neuronal norepinephrine (NE) release evoked by angiotensin II (ANG II) or angiotensin III (ANG III) were studied in the rat adrenal medulla.	Norepinephrine	52-66	natriuretic peptide A	Rattus norvegicus	27-30
8574778-1	1995	Atrial natriuretic factor (ANF) effects on neuronal norepinephrine (NE) release evoked by angiotensin II (ANG II) or angiotensin III (ANG III) were studied in the rat adrenal medulla.	Norepinephrine	52-66	angiogenin	Rattus norvegicus	106-109
7655416-5	1995	NPY also augmented the contractile responses to prostaglandin F2 alpha, norepinephrine, and histamine, but not to serotonin.	Norepinephrine	72-86	neuropeptide Y	Canis lupus familiaris	0-3
7620718-4	1995	Both the ATP-site competitors (genistein and its inactive analogue, daidzein) and the substrate-site competitors (tyrphostins A-23, A-47 and the inactive analogue, A-1) reversibly inhibited noradrenaline (NA, (10 microM)) and KCl (125 mM) induced contractions, concentration-dependently.	Norepinephrine	190-203	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	164-167
7605896-13	1995	In the isolated perfused working rat heart, norepinephrine (3 x 10(-8) M) increased the expression of the proto-oncogenes c-fos and c-myc after 30 and 60 minutes, respectively.	Norepinephrine	44-58	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	122-127
7870311-12	1994	Many unspecific afferents to the cerebral cortex are potentially regulated by glucocorticoid receptors such as the noradrenaline and 5-hydroxytryptamine afferents, since their nerve cells of origin contain strong glucocorticoid receptor immunoreactivity.	Norepinephrine	115-128	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	78-101
7983079-0	1994	Atrial natriuretic factor modifies noradrenaline release in a sodium-free medium.	Norepinephrine	35-48	natriuretic peptide A	Rattus norvegicus	0-25
8069683-0	1994	Atrial natriuretic factor effects on norepinephrine uptake in discrete telencephalic and diencephalic nuclei of the rat.	Norepinephrine	37-51	natriuretic peptide A	Rattus norvegicus	0-25
8069683-1	1994	Atrial natriuretic factor (ANF) effects on norepinephrine (NE) uptake in olfactory bulb, preoptic, periventricular, supraoptic, paraventricular and arcuate nuclei and median eminence of the rat were studied.	Norepinephrine	43-57	natriuretic peptide A	Rattus norvegicus	0-25
8069683-1	1994	Atrial natriuretic factor (ANF) effects on norepinephrine (NE) uptake in olfactory bulb, preoptic, periventricular, supraoptic, paraventricular and arcuate nuclei and median eminence of the rat were studied.	Norepinephrine	43-57	natriuretic peptide A	Rattus norvegicus	27-30
8190093-8	1994	A rise in the intracellular calcium concentration was nevertheless observed in transfected COS cells but was much smaller than that observed in response to norepinephrine in cells also expressing the alpha 1B-adrenergic receptor.	Norepinephrine	156-170	adrenoceptor alpha 1B	Homo sapiens	200-228
7905411-6	1994	Results with receptor-specific agonists and antagonists indicate that norepinephrine interacts with the beta 1-adrenergic receptor to stimulate cell proliferation.	Norepinephrine	70-84	adrenergic receptor, beta 1	Mus musculus	104-130
7909482-0	1994	Release of acetylcholine and noradrenaline from the cholinergic and adrenergic afferents in rat hippocampal CA1, CA3 and dentate gyrus regions.	Norepinephrine	29-42	carbonic anhydrase 3	Rattus norvegicus	113-116
8307150-5	1994	The order of affinity of the bovine VMAT2 transporter to substrates is: serotonin &gt; dopamine = norepinephrine &gt; epinephrine.	Norepinephrine	98-112	solute carrier family 18 member A2	Rattus norvegicus	36-41
8149505-0	1994	Platelet activating factor impairs pressor responses to noradrenaline in the anaesthetized rat but does not mediate endotoxin-induced hyporeactivity.	Norepinephrine	56-69	PCNA clamp associated factor	Rattus norvegicus	0-26
8149505-2	1994	Platelet activating factor (PAF, 50 ng kg-1 h-1) similarly impaired pressor responsiveness to noradrenaline, although this effect was accompanied by marked hypotension.	Norepinephrine	94-107	PCNA clamp associated factor	Rattus norvegicus	0-26
8149505-2	1994	Platelet activating factor (PAF, 50 ng kg-1 h-1) similarly impaired pressor responsiveness to noradrenaline, although this effect was accompanied by marked hypotension.	Norepinephrine	94-107	PCNA clamp associated factor	Rattus norvegicus	28-31
7927117-6	1994	The results are interpreted to suggest that alpha 1A-adrenoceptor subtype mediates noradrenaline-induced contractions of the guinea-pig aorta and that activation of alpha 1A-adrenoceptor subtype in the guinea-pig aorta is probably linked to intracellular Ca++ release.	Norepinephrine	83-96	alpha-1A adrenergic receptor	Cavia porcellus	44-65
7907100-10	1994	The pressor areas of the VLM and DM were DBH positive, indicating the presence of norepinephrine, while the dFTG-PVG and FTL were not.	Norepinephrine	82-96	dopamine beta-hydroxylase	Felis catus	41-44
7937350-0	1994	Modulation of the rat adrenal medulla norepinephrine secretion in a sodium-free medium by atrial natriuretic factor.	Norepinephrine	38-52	natriuretic peptide A	Rattus norvegicus	90-115
8306892-14	1993	Comparison of the number of neurons that differentiated from control and treated embryos showed that inhibition of dopamine beta-hydroxylase, the enzyme catalysing the conversion of dopamine to noradrenaline, during the neural plate stages reduced substantially subsequent neuronal differentiation.	Norepinephrine	194-207	dopamine beta-hydroxylase (dopamine beta-monooxygenase) L homeolog	Xenopus laevis	115-140
8274274-2	1993	Here, we show that the modulation of this current by norepinephrine, serotonin, and histamine is mediated by protein kinase A in hippocampal CA1 neurons.	Norepinephrine	53-67	carbonic anhydrase 1	Homo sapiens	141-144
7904926-2	1993	Atrial natriuretic factor effects on neuronal noradrenaline release evoked by angiotensin II or III and high potassium solution plus angiotensin II and III in the rat hypothalamus were studied.	Norepinephrine	46-59	natriuretic peptide A	Rattus norvegicus	0-25
7904926-11	1993	Our results suggest that atrial natriuretic factor effects on noradrenaline release, evoked by angiotensin II, III and KCl, may be involved in the regulation of the central catecholamine pathways and sympathetic activity.	Norepinephrine	62-75	natriuretic peptide A	Rattus norvegicus	25-50
8263948-8	1993	These results lend further support to the notion that Fos and related gene products mediate some of the hypertrophic actions of norepinephrine.	Norepinephrine	128-142	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	54-57
8227954-0	1993	Neuropeptide Y potentiates noradrenaline-evoked vasoconstriction by an intracellular calcium-dependent mechanism.	Norepinephrine	27-40	pro-neuropeptide Y	Cavia porcellus	0-14
8227954-1	1993	The potentiating effect of neuropeptide Y (NPY) was examined by testing the influence of putative inhibitors of calcium entry on the NPY-enhanced contractile response to noradrenaline in the guinea pig uterine artery.	Norepinephrine	170-183	pro-neuropeptide Y	Cavia porcellus	133-136
8227954-3	1993	NPY (100-300 nM) enhanced noradrenaline-evoked vasoconstriction.	Norepinephrine	26-39	pro-neuropeptide Y	Cavia porcellus	0-3
8227954-4	1993	The potentiation by NPY was most prominent in low noradrenaline concentrations (30-300 nM) and the pD10 (-log molar concentration of agonist eliciting 10% of maximum contraction) value was increased from 6.43 +/- 0.07 to 6.97 +/- 0.11 (P &lt; 0.001, n = 6).	Norepinephrine	50-63	pro-neuropeptide Y	Cavia porcellus	20-23
8227954-6	1993	The intracellular calcium chelator quin-2 AM selectively abolished the NPY-induced enhancement of the contractile response to noradrenaline.	Norepinephrine	126-139	pro-neuropeptide Y	Cavia porcellus	71-74
7688893-7	1993	Noradrenaline (10 microM) exhibited different actions on the various HVA current components: (1) it prolonged the activation kinetics of omega-CgTx-sensitive currents, (2) it depressed by about 20% the size of DHP-sensitive currents, and (3) it had little or no effects on the residual DHP- and omega-CgTx-resistant current although intracellularly applied guanosine 5"-O-(3-thiotriphosphate) (GTP-gamma-S) prolonged its activation time course.	Norepinephrine	0-13	dihydropyrimidinase	Rattus norvegicus	210-213
8484505-9	1993	However, up to a dose of 30 micrograms/kg (A30), a dose-dependent decrease in the maximum percent changes of both epinephrine and norepinephrine occurred in response to INT.	Norepinephrine	130-144	immunoglobulin kappa variable 1-17	Homo sapiens	43-46
8448583-10	1993	The permeability effect of PAF was only slightly enhanced by noradrenaline.	Norepinephrine	61-74	PCNA clamp associated factor	Rattus norvegicus	27-30
8383262-4	1993	The effect of norepinephrine on calcium concentrations was less affected by thyrotropin in PC C13 transformed by the adenovirus E1A oncogene.	Norepinephrine	14-28	branched chain keto acid dehydrogenase E1 subunit alpha	Rattus norvegicus	128-131
1422575-3	1992	Here we examine the effect of various agonists and antagonists of 5-HT2/5-HT1C receptors on noradrenaline release in hippocampus of anaesthetized rats using microdialysis.	Norepinephrine	92-105	5-hydroxytryptamine receptor 2C	Rattus norvegicus	72-78
1422575-8	1992	The effect of DOI on noradrenaline output was prevented by pretreatment with the 5-HT2/5-HT1C receptor antagonist, ritanserin (0.4 mg kg-1, s.c.).	Norepinephrine	21-34	5-hydroxytryptamine receptor 2C	Rattus norvegicus	87-93
1327420-7	1992	Additionally, the effect of norepinephrine on the phosphorylation of GFAP and vimentin was blocked by alprenolol.	Norepinephrine	28-42	glial fibrillary acidic protein	Rattus norvegicus	69-73
1324861-6	1992	Angiotensin II (100 nmol/l) and norepinephrine (1 mumol/l) evoked marked increases in (Na+,K+)-ATPase activity in aortic intima-media incubated with 5 mmol/l glucose and 70 mumol/l myo-inositol, which were inhibited when adenosine deaminase was added or the medium myo-inositol omitted to inhibit myo-inositol transport.	Norepinephrine	32-46	adenosine deaminase	Oryctolagus cuniculus	221-240
1353301-9	1992	These results indicate that the inhibitory effects exerted by the sympathetic nervous system on insulin secretion are mediated not only by the classical neurotransmitter norepinephrine acting on alpha 2-adrenoceptors but also by a nonadrenergic cotransmitter that can maintain transmission under conditions of catecholamine deficiency.	Norepinephrine	170-184	insulin	Canis lupus familiaris	96-103
1593712-4	1992	At 60 minutes, the mean increases in 3H-inositol inositol phosphates induced by 3 x 10(-7) M endothelin-1 and 10(-3) M noradrenaline amounted to 341 and 530% of time-matched controls, respectively.	Norepinephrine	119-132	endothelin-1	Oryctolagus cuniculus	93-112
1372289-2	1992	We have postulated that atrial natriuretic peptide inhibits norepinephrine release in anterior hypothalamus, reducing excitation of sympathoinhibitory neurons, increasing sympathetic outflow, and elevating blood pressure in this model.	Norepinephrine	60-74	natriuretic peptide A	Rattus norvegicus	24-50
1322821-8	1992	Associated with the decreased choline acetyltransferase activity after 1 week was an enhanced phosphoinositide hydrolysis in response to norepinephrine, and after 2 weeks there were enhanced responses to norepinephrine and to ibotenate.	Norepinephrine	137-151	choline O-acetyltransferase	Rattus norvegicus	30-55
1322821-8	1992	Associated with the decreased choline acetyltransferase activity after 1 week was an enhanced phosphoinositide hydrolysis in response to norepinephrine, and after 2 weeks there were enhanced responses to norepinephrine and to ibotenate.	Norepinephrine	204-218	choline O-acetyltransferase	Rattus norvegicus	30-55
1348566-2	1992	Out of the established endocrine cell types only insulin (B-) cells contained immunoreactivity for serotonin and noradrenaline.	Norepinephrine	113-126	insulin	Cavia porcellus	49-56
1545496-4	1992	These results indicate that the actions of PGD2 depend upon serotonin and norepinephrine systems.	Norepinephrine	74-88	prostaglandin D2 synthase (brain)	Mus musculus	43-47
1659528-7	1991	In addition, total (dephosphorylated) MEKA was observed to increase after a 6-h treatment with norepinephrine or (Bu)2 cAMP, an effect which was dependent upon new protein synthesis.	Norepinephrine	95-109	phosducin	Homo sapiens	38-42
1657022-5	1991	On stimulation with the secretagogue noradrenaline, CRH(1-41) was released into the medium, while the precursor was not.	Norepinephrine	37-50	corticotropin releasing hormone	Mus musculus	52-55
1957706-3	1991	In contrast, calcitonin gene-related peptide elicited a concentration-dependent and pronounced (78-99%) relaxation of vesical arteries precontracted with endothelin-1, noradrenaline or prostaglandin F2 alpha.	Norepinephrine	168-181	Calcitonin gene-related peptide	Sus scrofa	13-44
1835717-5	1991	Noradrenaline-stimulated lipolysis was most effectively inhibited by small quantities of insulin in these depots.	Norepinephrine	0-13	insulin	Cavia porcellus	89-96
1835717-8	1991	Noradrenaline-stimulated lipolysis was more effectively inhibited by 100 muunit/ml insulin in adipocytes from the mesenteric and omental depot in those from any other site.	Norepinephrine	0-13	insulin	Cavia porcellus	83-90
1907104-2	1991	Intrarenal infusion of C16-PAF at hypotensive (2.5 ng.min-1.kg-1) or nonhypotensive (0.5 ng.min-1.kg-1) doses caused renal vasodilation and dose dependently antagonized the renal vasoconstrictor responses of intrarenal boluses of angiotensin II (ANG II) greater than norepinephrine (NE) greater than vasopressin (AVP).	Norepinephrine	267-281	PCNA clamp associated factor	Rattus norvegicus	27-30
2072294-10	1991	These findings indicate that endogenous opioids regulate the effects of norepinephrine in the CA3 region of the guinea pig hippocampus.	Norepinephrine	72-86	carbonic anhydrase 3	Cavia porcellus	94-97
2072294-11	1991	In addition, endogenously released norepinephrine appeared to act on GABAergic interneurons to increase the amplitude of the IPSP recorded in CA3 pyramidal cells.	Norepinephrine	35-49	carbonic anhydrase 3	Cavia porcellus	142-145
1685558-14	1991	Consistent with this finding, around 80% of the adenylyl cyclase stimulation by both (-)-noradrenaline and (-)-adrenaline was mediated through beta 1AR, around 20% through beta 2AR.	Norepinephrine	85-102	adrenoceptor beta 2	Homo sapiens	172-180
1652275-1	1991	Heart rate and force can be increased by noradrenaline and adrenaline through an interaction with both beta 1-adrenoceptors (beta 1AR) and beta 2-adrenoceptors (beta 2 AR).	Norepinephrine	41-54	adrenoceptor beta 2	Homo sapiens	161-170
1652035-1	1991	Low doses (10(-16)-10(-10) M) of endothelin-3 (ET-3) elicited continuous vasodilations of mesenteric arteries preconstricted with norepinephrine (NE) but not with KCl.	Norepinephrine	130-144	endothelin 3	Homo sapiens	33-45
1652035-1	1991	Low doses (10(-16)-10(-10) M) of endothelin-3 (ET-3) elicited continuous vasodilations of mesenteric arteries preconstricted with norepinephrine (NE) but not with KCl.	Norepinephrine	130-144	endothelin 3	Homo sapiens	47-51
1826282-9	1991	In vitro, [3H]thymidine incorporation into hepatocyte DNA in the presence of hepatocyte growth factor is greater if 10(-5) mol/L norepinephrine is also present in the media.	Norepinephrine	129-143	hepatocyte growth factor	Rattus norvegicus	77-101
1825843-8	1991	We compared the sensitivities of Ca2(+)- and phorbol ester-induced release of noradrenaline to the protein kinase inhibitors H-7 and polymyxin B and to antibodies raised against synaptic protein kinase C substrate B-50.	Norepinephrine	78-91	solute carrier family 9 member A2	Rattus norvegicus	125-144
2054955-0	1991	Endothelin-1 enhances vasoconstrictor responses to sympathetic nerve stimulation and noradrenaline in the rabbit ear artery.	Norepinephrine	85-98	endothelin-1	Oryctolagus cuniculus	0-12
2054955-2	1991	In rabbit isolated perfused ear arteries denuded of endothelium, a low concentration of endothelin-1 (0.1 nmol/L) that had no direct vasoconstrictor action produced slowly developing enhancements of vasoconstrictor responses to noradrenaline and sympathetic nerve stimulation.	Norepinephrine	228-241	endothelin-1	Oryctolagus cuniculus	88-100
1999358-8	1991	These findings indicate that the renin-angiotensin system prevents exaggerated renal vascular responses to chronic norepinephrine stimulation by preserving renal perfusion pressure.	Norepinephrine	115-129	renin	Canis lupus familiaris	33-38
1671029-9	1991	In addition, dopamine DA1 agonism caused further increases in norepinephrine concentration and plasma renin activity.	Norepinephrine	62-76	immunoglobulin heavy diversity 4-11 (non-functional)	Homo sapiens	22-25
2257445-2	1990	The role of protein kinase C (PKC) in mediating enhanced contractile responses of aortae and mesenteric arteries from male rats with 12-14 week streptozotocin-induced diabetes to noradrenaline (NA) was investigated using the PKC activator, phorbol 12,13-dibutyrate (PDB), and the PKC inhibitor, staurosporine.	Norepinephrine	179-192	protein kinase C, gamma	Rattus norvegicus	30-33
1697888-4	1990	The effect of VIP was inhibited by addition of norepinephrine or of nitrendipine or by exposing the cells to "unexpected" white light.	Norepinephrine	47-61	vasoactive intestinal peptide	Gallus gallus	14-17
2167733-4	1990	In superfused vas deferens preparations, NPY (0.3 microM) inhibited the stimulus-evoked overflow of both ATP and [3H]-noradrenaline ([3H]-NA) at 2 Hz, but only the stimulus-evoked release of [3H]-NA at 20 Hz.	Norepinephrine	118-131	pro-neuropeptide Y	Cavia porcellus	41-44
2164246-0	1990	Effect of high dose norepinephrine versus epinephrine on cerebral and myocardial blood flow during CPR.	Norepinephrine	20-34	cytochrome p450 oxidoreductase	Sus scrofa	99-102
2164246-2	1990	The administration of norepinephrine (NE) in doses of 0.12 and 0.16 mg/kg demonstrated a trend toward improved CBF and MBF during CPR over that seen with E 0.20 mg/kg in the same animal model.	Norepinephrine	22-36	cytochrome p450 oxidoreductase	Sus scrofa	130-133
2185153-8	1990	Insulin infusion (1.0 milliunits/kg/min) for 7 days during simultaneous infusion of norepinephrine did not further increase mean arterial pressure, which averaged 101 +/- 3 during norepinephrine and 98 +/- 2 mm Hg during insulin plus norepinephrine infusion.	Norepinephrine	84-98	insulin	Canis lupus familiaris	0-7
2348052-3	1990	50 nM Neuropeptide Y increased the amplitude of constriction caused by noradrenaline or brief trains of nerve stimulation, showing that it potentiated the effects of vasoconstrictors as it does in other arteries.	Norepinephrine	71-84	pro-neuropeptide Y	Cavia porcellus	6-20
2326502-1	1990	Neuropeptide Y (NPY) coexists with noradrenaline (NA) in many peripheral sympathetic nerves.	Norepinephrine	35-48	pro-neuropeptide Y	Cavia porcellus	0-14
2326502-1	1990	Neuropeptide Y (NPY) coexists with noradrenaline (NA) in many peripheral sympathetic nerves.	Norepinephrine	35-48	pro-neuropeptide Y	Cavia porcellus	16-19
2282373-3	1990	These effects of angiotensin II were reversed when tissues were pretreated with staurosporine (50 nM), an inhibitor of protein kinase C. The amplification of the alpha-adrenoceptor-mediated vasoconstrictor effects of thrombin and norepinephrine by angiotensin II were also reversed by pretreatment with staurosporine.	Norepinephrine	230-244	prothrombin	Oryctolagus cuniculus	217-225
2153070-1	1990	Inhibition of monoamine oxidase B (MAO B) by selective inhibitors pargyline and L-deprenyl increases dopamine (DA) and norepinephrine (NE) concentrations in nucleus accumbens (NACB) and is associated with reduction in cold water restraint-induced gastric mucosal injury, inhibition of basal gastric acid output, and regional gastric mucosal blood flow.	Norepinephrine	119-133	monoamine oxidase B	Rattus norvegicus	14-33
2153070-1	1990	Inhibition of monoamine oxidase B (MAO B) by selective inhibitors pargyline and L-deprenyl increases dopamine (DA) and norepinephrine (NE) concentrations in nucleus accumbens (NACB) and is associated with reduction in cold water restraint-induced gastric mucosal injury, inhibition of basal gastric acid output, and regional gastric mucosal blood flow.	Norepinephrine	119-133	monoamine oxidase B	Rattus norvegicus	35-40
2139164-1	1990	Recently, it has been reported that atrial natriuretic peptide (ANP) reverses or prevents acute renal failure induced by norepinephrine in rats.	Norepinephrine	121-135	natriuretic peptide A	Rattus norvegicus	36-62
25887954-2	2015	We have recently demonstrated that beta1-adrenoceptor (AR) activation by endogenous norepinephrine contributes to cardiomyocyte apoptosis in endotoxemic mice.	Norepinephrine	84-98	adrenergic receptor, beta 1	Mus musculus	35-53
25887954-2	2015	We have recently demonstrated that beta1-adrenoceptor (AR) activation by endogenous norepinephrine contributes to cardiomyocyte apoptosis in endotoxemic mice.	Norepinephrine	84-98	adrenergic receptor, beta 1	Mus musculus	55-57
34862463-10	2021	Finally, MEK1/2 inhibition suppressed reserpine, norepinephrine, and mTOR-induced antimicrobial responses.	Norepinephrine	49-63	mitogen-activated protein kinase kinase 2	Gallus gallus	9-15
34912235-0	2021	Neurogenic Hypertension Mediated Mitochondrial Abnormality Leads to Cardiomyopathy: Contribution of UPRmt and Norepinephrine-miR- 18a-5p-HIF-1alpha Axis.	Norepinephrine	110-124	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	137-147
34417358-9	2021	These data support our hypothesis that norepinephrine serves as a novelty signal to update HPC contextual representations via BAR activation-facilitated recruitment of new neurons.	Norepinephrine	39-53	adrenoceptor beta 2	Homo sapiens	126-129
34392133-7	2021	Not the selective norepinephrine reuptake inhibitor reboxetine but the selective serotonin reuptake inhibitors fluvoxamine and sertraline upregulated the PGD2-induced osteoprotegerin release, which was further amplified by morphine.	Norepinephrine	18-32	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	167-182
34355529-8	2021	Adrenaline, noradrenaline, and phenylephrine were highly efficacious alpha1-agonists at all three receptor subtypes.	Norepinephrine	12-25	immunoglobulin kappa variable 2D-30	Homo sapiens	69-75
34083626-3	2021	We found that senior investors display higher gray matter volume and increased structural brain connectivity in dopamine-related pathways, as well as a set of genes functionally associated with adrenaline and noradrenaline biosynthesis (SLC6A3, TH and SLC18A2), which is seemingly involved in reward processing and bodily stress responses during financial trading.	Norepinephrine	209-222	solute carrier family 6 member 3	Homo sapiens	237-243
34309518-8	2021	ADRA2 activation via brimonidine-induced vasoconstriction was greater in skin arterioles than in small skin arteries, and more potent than that with norepinephrine (NE).	Norepinephrine	149-163	adrenoceptor alpha 2A	Homo sapiens	0-5
34062902-5	2021	We utilized cell lines overexpressing alpha1A-, alpha1B- or alpha1D-ARs to investigate the effects of the antidepressants imipramine (IMI), desipramine (DMI), mianserin (MIA), reboxetine (REB), citalopram (CIT) and fluoxetine (FLU) on noradrenaline-induced second messenger generation by those receptors.	Norepinephrine	235-248	alpha-1-B glycoprotein	Homo sapiens	48-55
34812056-8	2021	The in vitro experiments revealed that treatments with norepinephrine markedly increased mRNAs and proteins of ATF2 and CBP/p300 and reduced mRNA and proteins of HDAC2 and HDAC5 in MN9D cells.	Norepinephrine	55-69	CREB binding protein	Mus musculus	120-128
34812056-9	2021	A ChIP assay showed that norepinephrine significantly increased CBP/p300 binding or reduced HDAC2 and HDAC5 binding on the TH promoter.	Norepinephrine	25-39	CREB binding protein	Rattus norvegicus	64-68
34104992-3	2021	One such mechanism involves the direct inhibition by corticosteroid hormones of monoamine transport mediated by the "uptake2" transporter, organic cation transporter 3 (OCT3), a high-capacity, low-affinity transporter for norepinephrine, epinephrine, dopamine, serotonin, and histamine.	Norepinephrine	222-236	OCTN3	Homo sapiens	169-173
35597283-8	2022	Consistent with this model, we show that CatE is an FeII-dependent 2,3-catechol dioxygenase with broad substrate specificity, YwnB is a NAD(P)H-dependent quinone reductase capable of reducing the oxidized and cyclized norepinephrine, adrenochrome, and YhdA is capable of reducing a number of FeIII-complexes, including PiuA-binding transport substrates.	Norepinephrine	218-232	cathepsin E	Homo sapiens	41-45
35580792-9	2022	When activated ex vivo, secretion of IL-17A and IL-22 by THT-KO T-lymphocytes was also found to be reduced, but could be partially rescued with supplementation of norepinephrine specifically.	Norepinephrine	163-177	interleukin 17A	Homo sapiens	37-43
35580792-9	2022	When activated ex vivo, secretion of IL-17A and IL-22 by THT-KO T-lymphocytes was also found to be reduced, but could be partially rescued with supplementation of norepinephrine specifically.	Norepinephrine	163-177	interleukin 22	Homo sapiens	48-53
2577226-0	1989	The interaction of cholecystokinin and its fragments with norepinephrine in the circulatory system of diabetic rats.	Norepinephrine	58-72	cholecystokinin	Rattus norvegicus	19-34
2577226-1	1989	The interaction of cholecystokinin (CCK-33) and its fragments, C-terminal octapeptide (CCK-8) and C-terminal tetrapeptide (CCK-4) with norepinephrine (NE) was studied in rats with streptozotocin (STZ)-induced diabetes.	Norepinephrine	135-149	cholecystokinin	Rattus norvegicus	19-34
2528911-7	1989	The studies show that insulin-induced hypoglycemia was associated with a rise in plasma cortisol, beta-endorphin, epinephrine, norepinephrine, and glucagon.	Norepinephrine	127-141	insulin	Canis lupus familiaris	22-29
2557609-3	1989	Adrenergic agonists increased the cAMP levels in EPA in the order of potency characteristic for beta 2-AR: isoproterenol greater than epinephrine greater than norepinephrine.	Norepinephrine	159-173	adrenoceptor beta 2	Homo sapiens	96-105
2670151-0	1989	Direct evidence that an increase in aortic norepinephrine level in response to insulin-induced hypoglycemia is due to increased adrenal norepinephrine output.	Norepinephrine	43-57	insulin	Canis lupus familiaris	79-86
2670151-0	1989	Direct evidence that an increase in aortic norepinephrine level in response to insulin-induced hypoglycemia is due to increased adrenal norepinephrine output.	Norepinephrine	136-150	insulin	Canis lupus familiaris	79-86
2670151-1	1989	This study reports on the major source of circulating norepinephrine that is known to increase, progressively, during sustained hypoglycemia induced by intravenous insulin administration.	Norepinephrine	54-68	insulin	Canis lupus familiaris	164-171
2648843-3	1989	Fetal plasma norepinephrine and epinephrine concentrations increased significantly during insulin infusion.	Norepinephrine	13-27	LOC105613195	Ovis aries	90-97
2648843-7	1989	Increases in fetal heart rate during both the noninfused and insulin-infused states correlated significantly with increases in norepinephrine concentration.	Norepinephrine	127-141	LOC105613195	Ovis aries	61-68
2481466-8	1989	These observations indicate that NPY and GAL are distributed differently in LC neurons from noradrenaline and DBH.	Norepinephrine	92-105	galanin and GMAP prepropeptide	Homo sapiens	41-44
2467979-0	1989	Characterization of bradykinin-stimulated release of noradrenaline from cultured bovine adrenal chromaffin cells.	Norepinephrine	53-66	kininogen 1	Bos taurus	20-30
2467979-2	1989	On exposure to bradykinin they released noradrenaline.	Norepinephrine	40-53	kininogen 1	Bos taurus	15-25
2467979-4	1989	Bradykinin released noradrenaline with an EC50 of about 2 nM, with maximum release (2-3 times control incubations) less than that elicited by high potassium or nicotine.	Norepinephrine	20-33	kininogen 1	Bos taurus	0-10
2761120-1	1989	Repetitive intermittent cold exposure (5 degrees C, 6 h/day, 4 weeks) (ICE) resulted in the same cold adaptability as assessed by an enhanced cold tolerance (less drop of colonic temperature at -5 degrees C) and nonshivering thermogenesis (NST) (greater noradrenaline-induced heat production) as that elicited by continuous cold exposure (5 degrees C, 4 weeks) (CA) in rats.	Norepinephrine	254-267	caspase 1	Rattus norvegicus	71-74
2735135-3	1989	Cortical noradrenaline levels in mice with Rb (8, 17) 1IEM were the lowest and brain stem levels the highest among the three groups investigated.	Norepinephrine	9-22	Robertsonian translocation, Chr 8 and 17, Inst of Experimental Medicine Leningrad 1	Mus musculus	43-58
3071444-4	1988	In the case of noradrenaline not only a normalization but also an explicit overcompensation could be observed by insulin treatment.	Norepinephrine	15-28	insulin	Canis lupus familiaris	113-120
2848203-9	1988	Furthermore, the beta 2-adrenoceptor-induced facilitation of noradrenaline release may in part be mediated by local stimulation of angiotensin II synthesis, which may occur by increased formation or activation of renin and/or increased availability of angiotensinogen.	Norepinephrine	61-74	adrenoceptor beta 2	Homo sapiens	17-36
3133810-7	1988	The norepinephrine levels paralleled the t-PA activity.	Norepinephrine	4-18	chromosome 20 open reading frame 181	Homo sapiens	41-45
3133810-11	1988	We conclude that desmopressin increases plasma norepinephrine in addition to t-PA and that the parallel time course of change suggests a possible role for norepinephrine in mediating endothelial cell t-PA release.	Norepinephrine	155-169	chromosome 20 open reading frame 181	Homo sapiens	200-204
2836013-11	1988	Bretylium tosylate incubation to prevent noradrenaline release produced a small but significant enhancement of the inhibitory effect of NPY on EFS at high frequencies.	Norepinephrine	41-54	pro-neuropeptide Y	Cavia porcellus	136-139
2979688-3	1987	Noradrenaline and adrenaline relaxed gallbladder strips, probably via beta 2-adrenoceptor stimulation.	Norepinephrine	0-13	adrenoceptor beta 2	Homo sapiens	70-89
2890581-1	1987	Natriuretic substances were purified from rat atrium (atrial natriuretic factor, ANF) and were shown to be identical with the inhibitor of norepinephrine-induced contraction of smooth muscle.	Norepinephrine	139-153	natriuretic peptide A	Rattus norvegicus	54-79
2890581-1	1987	Natriuretic substances were purified from rat atrium (atrial natriuretic factor, ANF) and were shown to be identical with the inhibitor of norepinephrine-induced contraction of smooth muscle.	Norepinephrine	139-153	natriuretic peptide A	Rattus norvegicus	81-84
3436374-7	1987	The MPi was well correlated with the direct measurement of mean arterial pressure before (r = 0.918, p less than 0.001) and during (r = 0.903, p less than 0.001) elevation of arterial pressure via norepinephrine infusion.	Norepinephrine	197-211	mannose phosphate isomerase	Rattus norvegicus	4-7
3313435-5	1987	In cells treated with adenosine deaminase (0.5 U/ml) or with theophylline (0.5 mM), PGI2 (40 nM) inhibited the lipolytic effect of norepinephrine (5 microM) and nicotinic acid acted synergistically with PGI2 at this level.	Norepinephrine	131-145	adenosine deaminase	Rattus norvegicus	22-41
3030118-3	1987	Epinephrine (E), isoproterenol (I), and dopamine (D) were compared with norepinephrine (N) for production of microthrombi during thrombin-induced disseminated intravascular coagulation (DIC) in rabbits.	Norepinephrine	72-86	prothrombin	Oryctolagus cuniculus	129-137
3452452-1	1987	Topical application of a standard dose of noradrenaline (NA) to the anesthetized rat mesentery evoked a vasoconstrictor response the latency of which was increased in a dose-dependent way by previous addition of PAF-acether or histamine but not by Lyso-PAF.	Norepinephrine	42-55	PCNA clamp associated factor	Rattus norvegicus	212-215
3452452-1	1987	Topical application of a standard dose of noradrenaline (NA) to the anesthetized rat mesentery evoked a vasoconstrictor response the latency of which was increased in a dose-dependent way by previous addition of PAF-acether or histamine but not by Lyso-PAF.	Norepinephrine	42-55	PCNA clamp associated factor	Rattus norvegicus	253-256
3480939-2	1987	However, availability of other selective MAO-B inhibitors have clearly shown that this is not the case, since the "cheese effect" is associated with the selective inhibition of MAO-A, the enzyme responsible for intraneuronal oxidation of noradrenaline.	Norepinephrine	238-251	monoamine oxidase B	Homo sapiens	41-46
33483878-5	2022	Studies in different experimental animal species and in humans indicate that KOR agonists decrease antidiuretic hormone (ADH) secretion and release from the hypothalamus and posterior pituitary; decrease response to ADH in kidneys; increase renal sympathetic nerve activity; and increase adrenaline, noradrenaline, and dopamine release from the adrenal medulla.	Norepinephrine	300-313	opioid receptor kappa 1	Homo sapiens	77-80
32662924-0	2021	Microglial CX3CR1 production increases in Alzheimer"s disease and is regulated by noradrenaline.	Norepinephrine	82-95	C-X3-C motif chemokine receptor 1	Homo sapiens	11-17
33291181-7	2021	A reaction kinetic model was developed that provided a quantitative description of norepinephrine-facilitated extracellular Hsp70 release, congruent with the experimental data.	Norepinephrine	83-97	heat shock protein family A (Hsp70) member 4	Homo sapiens	124-129
32914279-9	2020	Also, the silencing of dTRH in the TG mice normalized urine noradrenaline excretion, supporting the view that the cardiovascular effects of TRH involve the sympathetic system.	Norepinephrine	60-73	thyrotropin releasing hormone	Mus musculus	24-27
33117176-3	2020	They are related to two other adrenergic receptor families that also bind norepinephrine and epinephrine, the beta- and alpha2-, each with three subtypes (beta1, beta2, beta3, alpha2A, alpha2B, alpha2C).	Norepinephrine	74-88	immunoglobulin kappa variable 2D-30	Homo sapiens	155-160
32544482-9	2020	These findings suggest that under conditions of increased sympathetic tone, such as those related to stress, noradrenaline may sensitize masticatory muscle nociceptors to increase pain and desensitize muscle proprioceptors to alter muscle tone, through activation of alpha1 receptors.	Norepinephrine	109-122	immunoglobulin kappa variable 2D-30	Homo sapiens	267-273
32518084-0	2020	Stress-induced Norepinephrine Downregulates CCL2 in Macrophages to Suppress Tumor Growth in a Model of Malignant Melanoma.	Norepinephrine	15-29	chemokine (C-C motif) ligand 2	Mus musculus	44-48
32811805-3	2020	We observed that beta-catenin co-expressed with SLUG and norepinephrine (NE) in tumor tissues obtained from nude mice.	Norepinephrine	57-71	catenin (cadherin associated protein), beta 1	Mus musculus	17-29
32823962-0	2020	Simple and Cost-Effective Electrochemical Method for Norepinephrine Determination Based on Carbon Dots and Tyrosinase.	Norepinephrine	53-67	tyrosinase	Homo sapiens	107-117
32232832-7	2020	Exendin-4 significantly relaxed the capillaries pre-contracted by noradrenaline, which was abolished by denuding endothelium with CHAPS and inhibited by GLP-1R antagonist exendin-9-39, endothelium nitric oxide synthase (eNOS) inhibitor L-NAME, and the guanylate cyclase blocker ODQ, but not by cyclooxygenase inhibitor indomethacin.	Norepinephrine	66-79	glucagon-like peptide 1 receptor	Rattus norvegicus	153-159
32232832-7	2020	Exendin-4 significantly relaxed the capillaries pre-contracted by noradrenaline, which was abolished by denuding endothelium with CHAPS and inhibited by GLP-1R antagonist exendin-9-39, endothelium nitric oxide synthase (eNOS) inhibitor L-NAME, and the guanylate cyclase blocker ODQ, but not by cyclooxygenase inhibitor indomethacin.	Norepinephrine	66-79	nitric oxide synthase 3	Rattus norvegicus	185-218
32232832-7	2020	Exendin-4 significantly relaxed the capillaries pre-contracted by noradrenaline, which was abolished by denuding endothelium with CHAPS and inhibited by GLP-1R antagonist exendin-9-39, endothelium nitric oxide synthase (eNOS) inhibitor L-NAME, and the guanylate cyclase blocker ODQ, but not by cyclooxygenase inhibitor indomethacin.	Norepinephrine	66-79	nitric oxide synthase 3	Rattus norvegicus	220-224
32623336-4	2020	We demonstrated that YAP1 was dephosphorylated and translocated from the cytoplasm to the nucleus by norepinephrine, a process initiated by ADRB2/cAMP/protein kinase A activation.	Norepinephrine	101-115	cathelicidin antimicrobial peptide	Mus musculus	146-150
32332112-7	2020	These effects may result from coordinated regulation of bladder afferent activity via M3 muscarinic inhibition and beta3 adrenoreceptor activation by norepinephrine elevation due to norepinephrine transporter inhibition.	Norepinephrine	150-164	adrenoceptor beta 3	Rattus norvegicus	115-135
32319652-0	2020	The sympathetic transmitter norepinephrine inhibits VSMC proliferation induced by TGFbeta by suppressing the expression of the TGFbeta receptor ALK5 in aorta remodeling.	Norepinephrine	28-42	transforming growth factor alpha	Rattus norvegicus	82-89
32319652-0	2020	The sympathetic transmitter norepinephrine inhibits VSMC proliferation induced by TGFbeta by suppressing the expression of the TGFbeta receptor ALK5 in aorta remodeling.	Norepinephrine	28-42	transforming growth factor alpha	Rattus norvegicus	127-134
32319652-0	2020	The sympathetic transmitter norepinephrine inhibits VSMC proliferation induced by TGFbeta by suppressing the expression of the TGFbeta receptor ALK5 in aorta remodeling.	Norepinephrine	28-42	transforming growth factor, beta receptor 1	Rattus norvegicus	144-148
32319652-2	2020	The present study aimed to explore the impact of the sympathetic neurotransmitter norepinephrine (NE) on transforming growth factor (TGF) beta signaling and the role of NE in aortic remodeling.	Norepinephrine	82-96	transforming growth factor alpha	Rattus norvegicus	105-142
32486305-0	2020	Norepinephrine Inhibits the Proliferation of Human Bone Marrow-Derived Mesenchymal Stem Cells via beta2-Adrenoceptor-Mediated ERK1/2 and PKA Phosphorylation.	Norepinephrine	0-14	adrenoceptor beta 2	Homo sapiens	98-116
32293507-0	2020	Norepinephrine-stimulated HSCs secrete sFRP1 to promote HCC progression following chronic stress via augmentation of a Wnt16B/beta-catenin positive feedback loop.	Norepinephrine	0-14	secreted frizzled-related protein 1	Mus musculus	39-44
32293507-0	2020	Norepinephrine-stimulated HSCs secrete sFRP1 to promote HCC progression following chronic stress via augmentation of a Wnt16B/beta-catenin positive feedback loop.	Norepinephrine	0-14	catenin (cadherin associated protein), beta 1	Mus musculus	126-138
31689515-9	2020	The in vitro investigations of the effects of noradrenaline on microglia showed that noradrenaline through beta-adrenoceptor may influence Nrf2 expression also via CX3CR1-independent route.	Norepinephrine	85-98	C-X3-C motif chemokine receptor 1	Rattus norvegicus	164-170
31811856-3	2020	Noradrenaline increased alpha1B-adrenergic receptor-Rab5 interaction, which was blocked by paroxetine and by expression of the dominant-negative GRK2 mutant.	Norepinephrine	0-13	adrenoceptor alpha 1B	Homo sapiens	24-51
31910209-13	2020	Systemic 6-OHDA decreased adrenal medulla expression of catecholamine producing enzymes (TH and aromatic L-amino acid decarboxylase) and circulating levels of norepinephrine, which were attenuated by PPARgamma-activation.	Norepinephrine	159-173	peroxisome proliferator activated receptor gamma	Macaca mulatta	200-209
31152452-0	2019	Cx32 mediates norepinephrine-promoted EGFR-TKI resistance in a gap junction-independent manner in non-small-cell lung cancer.	Norepinephrine	14-28	gap junction protein beta 1	Homo sapiens	0-4
31152452-5	2019	In the present study, we show that the stress hormone norepinephrine (NE) promotes Afatinib resistance by upregulating Cx32 expression.	Norepinephrine	54-68	gap junction protein beta 1	Homo sapiens	119-123
31297718-3	2019	The analysis of noradrenaline effects on brain cells demonstrates that it also regulates the production of the chemokine CCL2.	Norepinephrine	16-29	chemokine (C-C motif) ligand 2	Mus musculus	121-125
31356684-0	2019	STAT1-NFkappaB crosstalk triggered by interferon gamma regulates noradrenaline-induced pineal hormonal production.	Norepinephrine	65-78	signal transducer and activator of transcription 1	Homo sapiens	0-5
31572182-6	2019	Here we report that, in vitro, activation of beta2-AR by norepinephrine and beta2-AR agonists promotes the formation of NPC-derived mature neurons, without affecting NPC survival or differentiation toward glial lineages.	Norepinephrine	57-71	adrenoceptor beta 2	Homo sapiens	45-53
31067439-7	2019	As noradrenaline has high potency at alpha1D-adrenceptors, these receptors mediate the fastest response and seem to be targets for neurally released noradrenaline especially to low frequency stimulation, with alpha1A-adrenoceptors being more important at high frequencies of stimulation.	Norepinephrine	3-16	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	209-216
31067439-7	2019	As noradrenaline has high potency at alpha1D-adrenceptors, these receptors mediate the fastest response and seem to be targets for neurally released noradrenaline especially to low frequency stimulation, with alpha1A-adrenoceptors being more important at high frequencies of stimulation.	Norepinephrine	149-162	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	209-216
31151791-2	2019	We recently reported on a covalently binding noradrenaline analog (FAUC37) facilitating crystallization of the beta2-adrenergic receptor (beta2ARH2.64C) in an active state.	Norepinephrine	45-58	adrenoceptor beta 2	Homo sapiens	111-136
31396845-0	2019	Noradrenaline modulates CD4+ T cell priming in rat experimental autoimmune encephalomyelitis: a role for the alpha1-adrenoceptor.	Norepinephrine	0-13	Cd4 molecule	Rattus norvegicus	24-27
30636447-8	2019	Increasing Pck2 was sufficient to promote hypertrophic growth similar to that caused by increasing Lin28a, whereas knocking down Pck2 attenuated norepinephrine-induced cardiac hypertrophy.	Norepinephrine	145-159	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	129-133
30660754-12	2019	The effect of chronic MPH to increase levels of DAT, NET and VMAT2 suggests that the drug might long-term loose some of its acute action to increase extracellular levels of dopamine and noradrenaline.	Norepinephrine	186-199	solute carrier family 18 member A2	Rattus norvegicus	61-66
30055194-4	2019	In contrast to NET, DAT and SERT, OCT3 has higher capacity and lower affinity for substrates, is sodium-independent, and is multi-specific, with the capacity to transport norepinephrine, dopamine, serotonin and histamine.	Norepinephrine	171-185	solute carrier family 6 member 3	Homo sapiens	20-23
30055194-4	2019	In contrast to NET, DAT and SERT, OCT3 has higher capacity and lower affinity for substrates, is sodium-independent, and is multi-specific, with the capacity to transport norepinephrine, dopamine, serotonin and histamine.	Norepinephrine	171-185	OCTN3	Homo sapiens	34-38
31503242-2	2019	On smooth muscle cells of pulmonary vessels there are postsynaptic alpha1A-, alpha1B-, alpha1D- and alpha2A-, alpha2B-, alpha2C-adrenoreceptors whose activation by norepinephrine induces vasoconstriction.	Norepinephrine	164-178	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	67-74
31061315-0	2019	Noradrenaline-Induced Relaxation of Urinary Bladder Smooth Muscle Is Primarily Triggered through the beta3-Adrenoceptor in Rats.	Norepinephrine	0-13	adrenoceptor beta 3	Rattus norvegicus	101-119
31061315-9	2019	In the presence of propranolol (10-6 M), noradrenaline-induced relaxation was competitively inhibited by bupranolol (3 x 10-7-3 x 10-6 M) or SR59230A (10-7-10-6 M; selective beta3-adrenoceptor antagonist), with their pA2 values calculated to be 6.64 and 7.27, respectively.	Norepinephrine	41-54	adrenoceptor beta 3	Rattus norvegicus	174-192
30325031-4	2019	The order of Kb values between drugs such as adrenaline hydrochloride, norepinephrine bitartrate, and propranolol hydrochloride with beta2 -AR is well consistent with that reported in the literature.	Norepinephrine	71-96	adrenoceptor beta 2	Homo sapiens	133-142
30353660-5	2019	Mincle expression localized in microglia within the PVN was markedly increased at 24 hours post-MI together with sympathetic hyperactivity, as indicated by measurement of the renal sympathetic nerve activity (RSNA) and norepinephrine (NE) concentration.	Norepinephrine	219-233	C-type lectin domain family 4, member E	Rattus norvegicus	0-6
30253326-4	2019	beta2-adrenergic receptors are much more sensitive to epinephrine than to norepinephrine.	Norepinephrine	74-88	hemoglobin, beta adult minor chain	Mus musculus	0-5
29501506-9	2018	In this article, we review the effects of G-protein coupled receptors (GPCR) and neuromodulators, including acetylcholine, noradrenalin, serotonin and dopamine, on working memory and TRPC channels.	Norepinephrine	123-135	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	42-69
30126894-7	2018	In response to an increased norepinephrine (NE) level, expression of beta3-adrenoceptor was significantly upregulated, and the downstream protein kinase A (PKA) pathway was activated, as indicated by enhanced phosphorylation of whole PKA substrates, in particular, the hormone-sensitive lipase (HSL) in adipocytes.	Norepinephrine	28-42	lipase, hormone sensitive	Mus musculus	269-293
30126894-7	2018	In response to an increased norepinephrine (NE) level, expression of beta3-adrenoceptor was significantly upregulated, and the downstream protein kinase A (PKA) pathway was activated, as indicated by enhanced phosphorylation of whole PKA substrates, in particular, the hormone-sensitive lipase (HSL) in adipocytes.	Norepinephrine	28-42	lipase, hormone sensitive	Mus musculus	295-298
29878130-9	2018	Similarly, UCP2 and UCP3 protein levels were increased in differentiated adipocytes upon acute norepinephrine stimulation.	Norepinephrine	95-109	uncoupling protein 3	Homo sapiens	20-24
29900525-9	2018	Interestingly, the exchange protein directly activated by cAMP (Epac) agonist 8-pCPT-2"-O-Me-cAMP (50 muM) also up-regulated ICl.vol , and the noradrenaline-induced increase of ICl.vol in 0.6 T was reversed or prevented by the Epac inhibitor ESI-09 (10 muM).	Norepinephrine	143-156	Rap guanine nucleotide exchange factor 3	Homo sapiens	64-68
29900525-9	2018	Interestingly, the exchange protein directly activated by cAMP (Epac) agonist 8-pCPT-2"-O-Me-cAMP (50 muM) also up-regulated ICl.vol , and the noradrenaline-induced increase of ICl.vol in 0.6 T was reversed or prevented by the Epac inhibitor ESI-09 (10 muM).	Norepinephrine	143-156	Rap guanine nucleotide exchange factor 3	Homo sapiens	227-231
29900525-10	2018	CONCLUSION AND IMPLICATIONS: These data show that ICl.vol evoked by cell swelling of human atrial myocytes is up-regulated by noradrenaline via a PKA-independent cAMP/Epac pathway in human atrial myocytes.	Norepinephrine	126-139	Rap guanine nucleotide exchange factor 3	Homo sapiens	167-171
30139713-5	2018	The alpha1A- and alpha1D-adrenoceptor antagonist tamsulosin antagonized noradrenaline responses with high affinity (pKD = 9.7 +- 0.3), whilst BMY7378 (100 nM) (alpha1D-adrenoceptor antagonist) failed to antagonize responses.	Norepinephrine	72-85	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	4-11
30106035-6	2018	In essence, the literature reviewed herein supports our hypothesis of a tripartite neuroprotective role for noradrenaline in combating PD-related neuropathology and motor dysfunction via (1) inhibiting nigral microglial activation &amp; pro-inflammatory mediator production, (2) promoting the synthesis of neurotrophic factors from midbrain astrocytes and (3) downregulating alpha-synuclein gene expression and protein abundance in a beta2-AR-dependent manner.	Norepinephrine	108-121	adrenoceptor beta 2	Homo sapiens	434-442
29084442-7	2018	Endocan concentration was correlated positively with renalase ( r = .2, P = .047) and norepinephrine ( r = .25, P = .02).	Norepinephrine	86-100	endothelial cell specific molecule 1	Homo sapiens	0-7
29329285-7	2018	We also provide evidence, from coarse grain MD simulations that the CHOL sites observed in the DAT crystal structures are preserved in all human monoamine transporters (dopamine, serotonin and norepinephrine), suggesting that our findings might extend to the entire family.	Norepinephrine	193-207	solute carrier family 6 member 3	Homo sapiens	95-98
28549109-7	2018	Indeed, a positive correlation was observed between the serum levels of norepinephrine and IL-18 in patients with chest pain.	Norepinephrine	72-86	interleukin 18	Homo sapiens	91-96
28983964-1	2018	Expression of brain-derived neurotrophic factor (BDNF) is induced in cultured rat cortical astrocytes by catecholamines norepinephrine and dopamine as well as selective alpha1 and beta adrenergic agonists.	Norepinephrine	120-134	brain-derived neurotrophic factor	Rattus norvegicus	14-47
28983964-1	2018	Expression of brain-derived neurotrophic factor (BDNF) is induced in cultured rat cortical astrocytes by catecholamines norepinephrine and dopamine as well as selective alpha1 and beta adrenergic agonists.	Norepinephrine	120-134	brain-derived neurotrophic factor	Rattus norvegicus	49-53
28983964-4	2018	We show that in cortical astrocytes BDNF exon IV and exon VI containing mRNAs are induced by dopamine and norepinephrine via CREB-dependent signaling and that this regulation is mediated by a mechanism that is distinct from activity-dependent CREB-mediated activation of BDNF transcription in neurons.	Norepinephrine	106-120	brain-derived neurotrophic factor	Rattus norvegicus	36-40
28983964-4	2018	We show that in cortical astrocytes BDNF exon IV and exon VI containing mRNAs are induced by dopamine and norepinephrine via CREB-dependent signaling and that this regulation is mediated by a mechanism that is distinct from activity-dependent CREB-mediated activation of BDNF transcription in neurons.	Norepinephrine	106-120	brain-derived neurotrophic factor	Rattus norvegicus	271-275