PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31419642-0	2019	A combined experimental and computational study on peptide nucleic acid (PNA) analogues of tumor suppressive miRNA-34a.	Peptide Nucleic Acids	51-71	microRNA 34a	Homo sapiens	109-118
9826777-0	1998	Modified (PNA, 2"-O-methyl and phosphoramidate) anti-TAR antisense oligonucleotides as strong and specific inhibitors of in vitro HIV-1 reverse transcription.	Peptide Nucleic Acids	10-13	RNA binding motif protein 8A	Homo sapiens	53-56
8318003-6	1993	Peak 1 preferred Tos-Gly-Pro-Arg, p-nitroanilide (-pNA) substrate; Peaks 2-4 preferred benzyloxycarbonyl-Val-Leu-Gly-Arg-pNA.	Peptide Nucleic Acids	50-54	pseudopodium enriched atypical kinase 1	Homo sapiens	0-6
2417829-7	1985	The affinity with Ricin-Sepharose indicated that most of the FS-alpha and some of the TM-alpha may contain terminal sialic acid and the penultimate structure, Gal beta 1----4G1cNAc; the affinity with PNA-Sepharose indicated that both may also contain terminal sialic acid and the penultimate structure, Gal beta 1----3GalNAc.	Peptide Nucleic Acids	200-203	bridge-like lipid transfer protein family member 1	Homo sapiens	61-69
9258444-5	1997	To improve cellular uptake of a PNA sequence, it was conjugated to a D-amino acid analog of insulin-like growth factor 1 (IGF1), which binds selectively to the cell surface receptor for insulin-like growth factor 1 (IGF1R).	Peptide Nucleic Acids	32-35	insulin-like growth factor 1	Mus musculus	92-120
9258444-5	1997	To improve cellular uptake of a PNA sequence, it was conjugated to a D-amino acid analog of insulin-like growth factor 1 (IGF1), which binds selectively to the cell surface receptor for insulin-like growth factor 1 (IGF1R).	Peptide Nucleic Acids	32-35	insulin-like growth factor 1	Mus musculus	122-126
9258444-5	1997	To improve cellular uptake of a PNA sequence, it was conjugated to a D-amino acid analog of insulin-like growth factor 1 (IGF1), which binds selectively to the cell surface receptor for insulin-like growth factor 1 (IGF1R).	Peptide Nucleic Acids	32-35	insulin-like growth factor 1	Mus musculus	186-214
9258444-5	1997	To improve cellular uptake of a PNA sequence, it was conjugated to a D-amino acid analog of insulin-like growth factor 1 (IGF1), which binds selectively to the cell surface receptor for insulin-like growth factor 1 (IGF1R).	Peptide Nucleic Acids	32-35	insulin-like growth factor I receptor	Mus musculus	216-221
9028737-6	1997	Peptide nucleic acid (PNA) clamping was used to improve the K-ras ASA assay.	Peptide Nucleic Acids	22-25	KRAS proto-oncogene, GTPase	Homo sapiens	60-65
7841322-6	1994	125I-rHir inhibition of alpha-thrombin, measured by an assay utilizing the chromogenic tripeptide substrate H-D-Phe-Pip-Arg-pNA (S-2238), was observed to be non-competitive of linear mixed-type having a Ki of 1.61 pM and an alpha Ki of 1.09 pM.	Peptide Nucleic Acids	124-127	prolactin induced protein	Homo sapiens	116-119
34750687-6	2022	Here, we discuss how non-lytic AMP and BPP-PMO/PNA conjugates translocate across the cytoplasmic membrane via receptor-mediated transport, such as the cytoplasmic membrane transporters SbmA, MdtM/YjiL, and/or YgdD, or via a less well described autonomous process.	Peptide Nucleic Acids	47-50	androgen receptor	Homo sapiens	185-189
33922958-4	2021	Herein, we explored two different anti-miR oligonucleotides; peptide nucleic acid (PNAs) and phosphorothioates (PS) for ischemic stroke therapy.	Peptide Nucleic Acids	61-81	microRNA 615	Mus musculus	39-42
33922958-13	2021	We noted PNA-based anti-miR showed superior efficacy compared to PS-based anti-miR.	Peptide Nucleic Acids	9-12	microRNA 615	Mus musculus	24-27
32098827-3	2020	We developed a pHLIP-peptide nucleic acid (PNA) conjugate as an antisense reagent to reduce expression of the otherwise undruggable DNA double-strand break repair factor, KU80, and thereby radiosensitize tumor cells.	Peptide Nucleic Acids	43-46	X-ray repair complementing defective repair in Chinese hamster cells 5	Mus musculus	171-175
31419642-0	2019	A combined experimental and computational study on peptide nucleic acid (PNA) analogues of tumor suppressive miRNA-34a.	Peptide Nucleic Acids	73-76	microRNA 34a	Homo sapiens	109-118
31419642-7	2019	The design and synthesis of three PNA-based oligomers of different length was described, and their interaction with two binding sites on the target MYCN mRNA was investigated by molecular dynamics simulation, and spectroscopic techniques (CD, UV).	Peptide Nucleic Acids	34-37	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	148-152
30802686-6	2019	The other was designed around an anti-miR-21 composed of peptide nucleic acid (PNA) and employed a block copolymer of poly(lactic acid) and hyperbranched polyglycerol (PLA-HPG).	Peptide Nucleic Acids	57-77	microRNA 21	Homo sapiens	38-44
15975048-12	2005	Encouraging results have been reported utilizing a PNA-based antisense strategy for inhibition of N-Myc expression in neuroblastoma.	Peptide Nucleic Acids	51-54	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	98-103
29439013-3	2018	The aim of this study was to test the hypothesis that Affibody-based peptide nucleic acid (PNA)-mediated pretargeted therapy of human epidermal growth factor receptor 2 (HER2)-expressing cancer extends survival without accompanying renal toxicity.	Peptide Nucleic Acids	91-94	erb-b2 receptor tyrosine kinase 2	Homo sapiens	134-168
29439013-3	2018	The aim of this study was to test the hypothesis that Affibody-based peptide nucleic acid (PNA)-mediated pretargeted therapy of human epidermal growth factor receptor 2 (HER2)-expressing cancer extends survival without accompanying renal toxicity.	Peptide Nucleic Acids	91-94	erb-b2 receptor tyrosine kinase 2	Homo sapiens	170-174
24121392-0	2013	PNA as a potential modulator of COL7A1 gene expression in dominant dystrophic epidermolysis bullosa: a physico-chemical study.	Peptide Nucleic Acids	0-3	collagen type VII alpha 1 chain	Homo sapiens	32-38
22183093-3	2012	[Re(CO)(3)(L-N(3))]Br could be conjugated, on a solid phase, to a peptide nucleic acid (PNA) oligomer using the copper(I)-catalyzed azide-alkyne cycloaddition reaction (Cu-AAC, "click" chemistry) and an alkyne-containing PNA building block to give Re-PNA.	Peptide Nucleic Acids	88-91	glycine-N-acyltransferase	Homo sapiens	172-175
18066119-6	2007	THP-1 caspase-3 activity was greatest (p <or= 0.05) with Rh2 (7.6 +/- 1.1 nmol/L pNA), followed by LFRh2 (5.9 +/- 1.0 nmol/L pNA) and PT (5.0 +/- 0.8 nmol/L pNA), whereas PD was similar to control cells.	Peptide Nucleic Acids	84-87	GLI family zinc finger 2	Homo sapiens	0-5
18066119-6	2007	THP-1 caspase-3 activity was greatest (p <or= 0.05) with Rh2 (7.6 +/- 1.1 nmol/L pNA), followed by LFRh2 (5.9 +/- 1.0 nmol/L pNA) and PT (5.0 +/- 0.8 nmol/L pNA), whereas PD was similar to control cells.	Peptide Nucleic Acids	128-131	GLI family zinc finger 2	Homo sapiens	0-5
18066119-6	2007	THP-1 caspase-3 activity was greatest (p <or= 0.05) with Rh2 (7.6 +/- 1.1 nmol/L pNA), followed by LFRh2 (5.9 +/- 1.0 nmol/L pNA) and PT (5.0 +/- 0.8 nmol/L pNA), whereas PD was similar to control cells.	Peptide Nucleic Acids	128-131	GLI family zinc finger 2	Homo sapiens	0-5
17165763-3	2006	We show that a GPNA oligomer designed to bind to the transcriptional start-site of human E-cadherin gene induces potent and sequence-specific antisense effects and is less toxic to the cells than the corresponding PNA-polyarginine conjugate.	Peptide Nucleic Acids	16-19	cadherin 1	Homo sapiens	89-99
16299354-3	2005	Here, we show that a short antisense chimeric peptide nucleic acid (PNA) oligonucleotide conjugated to a polypeptide containing eight Ser-Arg repeats (SR)(8) can modulate splicing of bcl-x both in vitro and in vivo and induces apoptosis in HeLa cells.	Peptide Nucleic Acids	68-71	BCL2 like 1	Homo sapiens	183-188
30307373-2	2019	This acts as a prelude to the rewarding collaborative studies in the Gait and Wood research groups aimed toward the enhanced delivery of charge neutral ON drugs and the development of a series of Arg-rich cell-penetrating peptides called Pip (peptide nucleic acid/phosphorodiamidate morpholino oligonucleotide [PNA/PMO] internalization peptides) as conjugates of such ONs.	Peptide Nucleic Acids	311-314	prolactin induced protein	Homo sapiens	238-241
23178988-4	2013	Blockade of miR-375 via peptide nucleic acid (PNA)-based antisense oligonucleotides (ASOs) increased the migration of chondrogenic progenitors, the formation of precartilage condensations and the expression level of cadherin-7.	Peptide Nucleic Acids	46-49	microRNA 375	Homo sapiens	12-19
23178988-4	2013	Blockade of miR-375 via peptide nucleic acid (PNA)-based antisense oligonucleotides (ASOs) increased the migration of chondrogenic progenitors, the formation of precartilage condensations and the expression level of cadherin-7.	Peptide Nucleic Acids	46-49	cadherin 7	Homo sapiens	216-226
22079638-4	2011	Blockade of miR-34a via PNA-based antisense oligonucleotides (ASOs) recovered the chondro-inhibitory actions of JNK inhibitor on migration of chondrogenic progenitors and the formation of precartilage condensation.	Peptide Nucleic Acids	24-27	microRNA 34a	Gallus gallus	12-19
16916990-3	2006	We combined OCEAN with peptide-nucleic-acid (PNA)-based variant enrichment to detect and simultaneously genotype v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) codon 12 sequence variants in human tissue specimens.	Peptide Nucleic Acids	23-43	KRAS proto-oncogene, GTPase	Rattus norvegicus	167-171
16448083-1	2006	An acetophenone containing PNA-based reagent was designed for the direct and site-specific synthesis of a cis-syn thymidine dimer lesion in genomic DNA.	Peptide Nucleic Acids	27-30	synemin	Homo sapiens	91-94
15148357-2	2004	We describe the specific down regulation of cell surface associated CD40 protein expression by use of a peptide nucleic acid (PNA) antisense inhibitor, ISIS 208529, that is designed to bind to the 3" end of the exon 6 splice junction within the primary CD40 transcript.	Peptide Nucleic Acids	126-129	CD40 antigen	Mus musculus	68-72
15944022-8	2005	Focal downregulation of GalR2, which had been achieved in rats by intrahippocampal infusion of anti-GalR2 peptide nucleic acid (PNA) antisense, significantly increased the severity of perforant path stimulation- induced SE.	Peptide Nucleic Acids	128-131	galanin receptor 2	Rattus norvegicus	24-29
15944022-8	2005	Focal downregulation of GalR2, which had been achieved in rats by intrahippocampal infusion of anti-GalR2 peptide nucleic acid (PNA) antisense, significantly increased the severity of perforant path stimulation- induced SE.	Peptide Nucleic Acids	128-131	galanin receptor 2	Rattus norvegicus	100-105
15148357-2	2004	We describe the specific down regulation of cell surface associated CD40 protein expression by use of a peptide nucleic acid (PNA) antisense inhibitor, ISIS 208529, that is designed to bind to the 3" end of the exon 6 splice junction within the primary CD40 transcript.	Peptide Nucleic Acids	126-129	CD40 antigen	Mus musculus	253-257
14982931-2	2004	To explore the biochemical and structural bases for the adenosine phosphoramidate hydrolase activity of rabbit Hint, we synthesized novel substrates linking a p-nitroaniline group to adenylate (AMP-pNA) and inhibitors that consist of an adenosine group and 5"-sulfamoyl (AdoOSO(2)NH(2)) or N-ethylsulfamoyl (AdoOSO(2)NHCH(2)CH(3)) group.	Peptide Nucleic Acids	198-201	adenosine 5'-monophosphoramidase HINT1	Oryctolagus cuniculus	111-115
11106372-2	2000	The present studies describe an antisense imaging agent comprised of an iodinated peptide nucleic acid (PNA) conjugated to a monoclonal antibody to the rat transferrin receptor by using avidin-biotin technology.	Peptide Nucleic Acids	104-107	transferrin	Rattus norvegicus	156-167
12692682-3	2003	By combining peptide nucleic acid (PNA)-based DNA clamping with a fluorescence hybridization probe assay, we developed a new and highly sensitive technique for the detection of known mutations within the Bcr/Abl kinase domain.	Peptide Nucleic Acids	35-38	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	204-211
14751834-8	2003	Peptide nucleic acid (PNA) dodecamers antisense to CCND1 and MYC mRNAs were then extended from the N-terminus of IGF1, followed by a chelator peptide, using Fmoc coupling for all residues.	Peptide Nucleic Acids	22-25	cyclin D1	Homo sapiens	51-56
14751834-8	2003	Peptide nucleic acid (PNA) dodecamers antisense to CCND1 and MYC mRNAs were then extended from the N-terminus of IGF1, followed by a chelator peptide, using Fmoc coupling for all residues.	Peptide Nucleic Acids	22-25	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	61-64
14751834-8	2003	Peptide nucleic acid (PNA) dodecamers antisense to CCND1 and MYC mRNAs were then extended from the N-terminus of IGF1, followed by a chelator peptide, using Fmoc coupling for all residues.	Peptide Nucleic Acids	22-25	insulin like growth factor 1	Homo sapiens	113-117
12761352-8	2003	Reversal potential measurements showed that the human P2X5 receptor was permeable to calcium (PCa/PNa = 1.5) and N-methyl-d-glucamine (NMDG) (PNMDG/PNa = 0.4); it was also permeable to chloride (PCl/PNa = 0.5) but not gluconate (Pgluc/PNa = 0.01) ions.	Peptide Nucleic Acids	98-101	purinergic receptor P2X 5	Homo sapiens	54-58
12761352-8	2003	Reversal potential measurements showed that the human P2X5 receptor was permeable to calcium (PCa/PNa = 1.5) and N-methyl-d-glucamine (NMDG) (PNMDG/PNa = 0.4); it was also permeable to chloride (PCl/PNa = 0.5) but not gluconate (Pgluc/PNa = 0.01) ions.	Peptide Nucleic Acids	148-151	purinergic receptor P2X 5	Homo sapiens	54-58
11454693-2	2001	In this study, three anti-PML adamantyl-conjugated peptide nucleic acid (PNA) oligomers previously described as in vitro inhibitors of PML/RARalpha translation were combined and used to block PML/RARalpha synthesis in NB4 cells.	Peptide Nucleic Acids	73-76	PML nuclear body scaffold	Homo sapiens	26-29
11454693-2	2001	In this study, three anti-PML adamantyl-conjugated peptide nucleic acid (PNA) oligomers previously described as in vitro inhibitors of PML/RARalpha translation were combined and used to block PML/RARalpha synthesis in NB4 cells.	Peptide Nucleic Acids	73-76	PML nuclear body scaffold	Homo sapiens	135-138
11454693-2	2001	In this study, three anti-PML adamantyl-conjugated peptide nucleic acid (PNA) oligomers previously described as in vitro inhibitors of PML/RARalpha translation were combined and used to block PML/RARalpha synthesis in NB4 cells.	Peptide Nucleic Acids	73-76	retinoic acid receptor alpha	Homo sapiens	139-147
11454693-2	2001	In this study, three anti-PML adamantyl-conjugated peptide nucleic acid (PNA) oligomers previously described as in vitro inhibitors of PML/RARalpha translation were combined and used to block PML/RARalpha synthesis in NB4 cells.	Peptide Nucleic Acids	73-76	PML nuclear body scaffold	Homo sapiens	135-138
11454693-2	2001	In this study, three anti-PML adamantyl-conjugated peptide nucleic acid (PNA) oligomers previously described as in vitro inhibitors of PML/RARalpha translation were combined and used to block PML/RARalpha synthesis in NB4 cells.	Peptide Nucleic Acids	73-76	retinoic acid receptor alpha	Homo sapiens	196-204
10933939-4	2000	Transferrin (Tf) was conjugated with PNA via a reversible disulfide bond using N-succinimidyl-3-(2-pyridyldithio)propionate.	Peptide Nucleic Acids	37-40	transferrin	Homo sapiens	0-11
10933939-4	2000	Transferrin (Tf) was conjugated with PNA via a reversible disulfide bond using N-succinimidyl-3-(2-pyridyldithio)propionate.	Peptide Nucleic Acids	37-40	transferrin	Homo sapiens	13-15