PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
10814890-0	2000	Formation and persistence of O(6)-methylguanine in the mouse colon following treatment with 1,2-dimethylhydrazine as measured by an O(6)-alkylguanine-DNA alkyltransferase inactivation assay.	1,2-Dimethylhydrazine	92-113	O-6-methylguanine-DNA methyltransferase	Mus musculus	132-170
11404301-5	2001	In contrast, NPY expression was upregulated in the dorsomedial hypothalamus (DMH) in pair-fed OLETF rats.	1,2-Dimethylhydrazine	77-80	neuropeptide Y	Rattus norvegicus	13-16
11404301-6	2001	A similar DMH NPY overexpression was evident in 5-wk-old preobese OLETF rats.	1,2-Dimethylhydrazine	10-13	neuropeptide Y	Rattus norvegicus	14-17
11294744-5	2001	Injection of muscimol into the DMH suppressed Fos expression in the PVN associated with air stress but not with hemorrhage.	1,2-Dimethylhydrazine	31-34	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	46-49
11135064-7	2001	In nonsclerosed glomeruli, synaptopodin was significantly less expressed in all groups of INS and in CNF compared with normal (P < 0.0001 for both L and A, in each MCD, DMH, FSGS, and CNF).	1,2-Dimethylhydrazine	172-175	synaptopodin	Homo sapiens	27-39
11135064-8	2001	In INS, synaptopodin expression decreased in order from MCD to DMH to FSGS, reaching statistical significance between MCD and FSGS (P = 0.001 for L and P = 0.05 for A).	1,2-Dimethylhydrazine	63-66	synaptopodin	Homo sapiens	8-20
11195457-10	2000	Interestingly a germline p53 mutation increased the incidence of DMH-induced colon, lung, hepatic, and uterine tumors, while having limited effects on OHBBN-induced bladder tumors.	1,2-Dimethylhydrazine	65-68	transformation related protein 53, pseudogene	Mus musculus	25-28
11819677-5	2000	The results also showed that DMH increased labeling index (LI) of proliferating cell nuclear antigen (PCNA) of intestinal mucosa and the expression of ras-p21.	1,2-Dimethylhydrazine	29-32	proliferating cell nuclear antigen	Rattus norvegicus	66-100
11819677-5	2000	The results also showed that DMH increased labeling index (LI) of proliferating cell nuclear antigen (PCNA) of intestinal mucosa and the expression of ras-p21.	1,2-Dimethylhydrazine	29-32	proliferating cell nuclear antigen	Rattus norvegicus	102-106
11819677-5	2000	The results also showed that DMH increased labeling index (LI) of proliferating cell nuclear antigen (PCNA) of intestinal mucosa and the expression of ras-p21.	1,2-Dimethylhydrazine	29-32	KRAS proto-oncogene, GTPase	Rattus norvegicus	155-158
11404301-7	2001	These findings suggest a role for DMH NPY upregulation in the etiology of OLETF hyperphagia and obesity.	1,2-Dimethylhydrazine	34-37	neuropeptide Y	Rattus norvegicus	38-41
11181454-0	2001	beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol.	1,2-Dimethylhydrazine	55-76	catenin beta 1	Rattus norvegicus	0-12
11181454-1	2001	Carcinogens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 1,2-dimethylhydrazine (DMH) induce colon tumors in the rat that contain mutations in beta-catenin, but the pattern of mutation differs from that found in human colon cancers.	1,2-Dimethylhydrazine	61-82	catenin beta 1	Rattus norvegicus	146-158
11181454-1	2001	Carcinogens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 1,2-dimethylhydrazine (DMH) induce colon tumors in the rat that contain mutations in beta-catenin, but the pattern of mutation differs from that found in human colon cancers.	1,2-Dimethylhydrazine	84-87	catenin beta 1	Rattus norvegicus	146-158
11181454-3	2001	Two dietary phytochemicals, chlorophyllin and indole-3-carbinol, given post-initiation, shifted the pattern of beta-catenin mutations in rat colon tumors induced by IQ and DMH.	1,2-Dimethylhydrazine	172-175	catenin beta 1	Rattus norvegicus	111-123
11181454-6	2001	Interestingly, many of the mutations that substituted critical Ser/Thr residues in beta-catenin were from a single group given DMH and 0.001% chlorophyllin, in which a statistically significant increase in colon tumor multiplicity was observed compared with the group given DMH only.	1,2-Dimethylhydrazine	127-130	catenin beta 1	Rattus norvegicus	83-95
11181454-6	2001	Interestingly, many of the mutations that substituted critical Ser/Thr residues in beta-catenin were from a single group given DMH and 0.001% chlorophyllin, in which a statistically significant increase in colon tumor multiplicity was observed compared with the group given DMH only.	1,2-Dimethylhydrazine	274-277	catenin beta 1	Rattus norvegicus	83-95
11078830-4	2000	The pectin-enriched diet induced upregulation of active caspase-1 subunit (20 kDa) and of caspase-3 precursor in DMH-treated rats.	1,2-Dimethylhydrazine	113-116	caspase 3	Rattus norvegicus	90-99
11078830-5	2000	Pectin enhanced caspase-3 activity in all colonocyte populations, in both non-DMH and DMH-treated rats.	1,2-Dimethylhydrazine	86-89	caspase 3	Rattus norvegicus	16-25
11078830-6	2000	The luminal colonocytes exhibited higher caspase-3 activity than proliferative colonocytes of rats fed a standard diet in non-DMH and DMH-treated rats, whereas in pectin-fed non-DMH-treated rats, equal activity was measured among all colonocyte populations.	1,2-Dimethylhydrazine	126-129	caspase 3	Rattus norvegicus	41-50
11078830-6	2000	The luminal colonocytes exhibited higher caspase-3 activity than proliferative colonocytes of rats fed a standard diet in non-DMH and DMH-treated rats, whereas in pectin-fed non-DMH-treated rats, equal activity was measured among all colonocyte populations.	1,2-Dimethylhydrazine	134-137	caspase 3	Rattus norvegicus	41-50
11078830-6	2000	The luminal colonocytes exhibited higher caspase-3 activity than proliferative colonocytes of rats fed a standard diet in non-DMH and DMH-treated rats, whereas in pectin-fed non-DMH-treated rats, equal activity was measured among all colonocyte populations.	1,2-Dimethylhydrazine	134-137	caspase 3	Rattus norvegicus	41-50
11078830-9	2000	In the DMH-treated rats, Bcl-2 expression was lower in all colonocytes harvested from rats fed pectin, relative to rats fed the standard diet.	1,2-Dimethylhydrazine	7-10	BCL2, apoptosis regulator	Rattus norvegicus	25-30
10803953-5	2000	Feeding the high-fat diet and DMH treatment caused higher activity of hepatic iNOS.	1,2-Dimethylhydrazine	30-33	nitric oxide synthase 2	Rattus norvegicus	78-82
10680593-1	2000	Summation of initiation by low doses of the indirect-acting non-hepatocarcinogen, 1,2-dimethylhydrazine (DMH) after proliferative stimulation with a necrogenic dose of carbon tetrachloride (CCl4) was investigated in terms of the induction of glutathione S-transferase placental form (GST-P) positive liver cell foci.	1,2-Dimethylhydrazine	82-103	C-C motif chemokine ligand 4	Rattus norvegicus	190-194
10680593-10	2000	In experiments I and IIA, the numbers and areas of GST-P-positive foci increased with the BrdU labeling index at the time of DMH treatment (maximum after 60 h).	1,2-Dimethylhydrazine	125-128	glutathione S-transferase pi 1	Rattus norvegicus	51-56
10680593-11	2000	In experiment HB, repeated exposure of DMH at 10 mg/kg, four times resulted in significant (P<0.05) increase in number and area of GST-P-positive foci compared with the single administration (40 mg/kg).	1,2-Dimethylhydrazine	39-42	glutathione S-transferase pi 1	Rattus norvegicus	134-139
11198268-5	2000	The results showed that after a single oral load of Orn, blood PUT, but not SPD and SPM, concentrations were significantly higher in DMH-treated rats compared with control rats, indicating enhancement of ODC activity.	1,2-Dimethylhydrazine	133-136	ornithine decarboxylase 1	Rattus norvegicus	204-207
10320707-8	1999	The present results show that centrally administrated CGRP induces heat production in the BAT specifically through the VMH or DMH.	1,2-Dimethylhydrazine	126-129	calcitonin related polypeptide alpha	Homo sapiens	54-58
9748583-13	1998	Parry, Enhanced restriction site mutation (RSM) analysis of 1, 2-dimethylhydrazine-induced mutations, using endogenous p53 intron sequences, Mutagenesis 12 (1997) pp.	1,2-Dimethylhydrazine	60-82	tumor protein p53	Homo sapiens	119-122
10334300-5	1999	After 10-days of food restriction (14% weight loss), density of MC4-R was significantly increased by 20-65% in the VMH, ARC, ME, and DMH, with no changes elsewhere.	1,2-Dimethylhydrazine	133-136	melanocortin 4 receptor	Rattus norvegicus	64-69
9886815-5	1999	Resuckling for 24 h induced a significant increase in NPY mRNA levels in the caudal portion of the ARH and in the DMH.	1,2-Dimethylhydrazine	114-117	neuropeptide Y	Rattus norvegicus	54-57
9886815-6	1999	Bromocriptine treatment did not alter the increase in NPY mRNA levels in the ARH, whereas the treatment greatly attenuated the increase in NPY mRNA in the DMH.	1,2-Dimethylhydrazine	155-158	neuropeptide Y	Rattus norvegicus	139-142
9886815-10	1999	Suckling-induced hyperprolactinemia did not participate in the increase in ARH NPY activity, whereas it played a major stimulatory role in suckling-induced activation of NPY neurons in the DMH and an inhibitory role in suckling-induced suppression of TIDA activity.	1,2-Dimethylhydrazine	189-192	neuropeptide Y	Rattus norvegicus	170-173
9891232-3	1998	IgG generated against the cytoplasmic, soluble p53 antigen from tumor-bearing rats prevents the carcinogenic effect of 1,2-dimethylhydrazine (DMH) decreasing significantly the number of tumor-bearing rats in vaccinated group compared with non vaccinated controls and preventing benign tumors from becoming malignant.	1,2-Dimethylhydrazine	119-140	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	47-50
9891232-3	1998	IgG generated against the cytoplasmic, soluble p53 antigen from tumor-bearing rats prevents the carcinogenic effect of 1,2-dimethylhydrazine (DMH) decreasing significantly the number of tumor-bearing rats in vaccinated group compared with non vaccinated controls and preventing benign tumors from becoming malignant.	1,2-Dimethylhydrazine	142-145	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	47-50
9458306-0	1998	Elevation in putrescine level and spermidine/spermine N1-acetyltransferase activity coincide with tumor development in 1, 2-dimethylhydrazine-induced rat colon.	1,2-Dimethylhydrazine	119-141	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	34-74
9683279-3	1998	Remarkably, the vegetables-fruit mixture given to DMH-treated rats decreased glutathione-S-transferase (h) and increased NDMA-demethylase activities (c), whereas the mixture given to controls increased glutathione-S-transferase (h) and decreased NDMA-demethylase activities (c).	1,2-Dimethylhydrazine	50-53	hematopoietic prostaglandin D synthase	Rattus norvegicus	77-102
9538119-4	1998	The corresponding Tage4 gene (tumor-associated glycoprotein E4) is also expressed in rat colon tumors induced by 1,2-dimethylhydrazine and in Min mouse intestinal adenomas.	1,2-Dimethylhydrazine	113-134	PVR cell adhesion molecule	Rattus norvegicus	18-23
9538119-4	1998	The corresponding Tage4 gene (tumor-associated glycoprotein E4) is also expressed in rat colon tumors induced by 1,2-dimethylhydrazine and in Min mouse intestinal adenomas.	1,2-Dimethylhydrazine	113-134	PVR cell adhesion molecule	Rattus norvegicus	30-62
9720607-1	1998	In the presence of a known colon carcinogen, 1,2-dimethyl hydrazine (DMH), the activity of beta-glucuronidase was found to be significantly increased in the distal colon, distal intestine, liver and colon contents and the activity of mucinase was increased in both the colon and fecal contents when compared to control rats.	1,2-Dimethylhydrazine	45-67	glucuronidase, beta	Rattus norvegicus	91-109
9720607-1	1998	In the presence of a known colon carcinogen, 1,2-dimethyl hydrazine (DMH), the activity of beta-glucuronidase was found to be significantly increased in the distal colon, distal intestine, liver and colon contents and the activity of mucinase was increased in both the colon and fecal contents when compared to control rats.	1,2-Dimethylhydrazine	69-72	glucuronidase, beta	Rattus norvegicus	91-109
9608642-0	1998	Predominant p53 G-->A transition mutation and enhanced cell proliferation in uterine sarcomas of CBA mice treated with 1,2-dimethylhydrazine.	1,2-Dimethylhydrazine	122-143	transformation related protein 53, pseudogene	Mus musculus	12-15
9458306-5	1998	iii) SSAT activity increased gradually in DMH-treated colon mucosa, which preceded elevation of tissue putrescine level, and coincided with tumor development.	1,2-Dimethylhydrazine	42-45	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	5-9
9530618-5	1997	In the fiber-free group, DMH treatment significantly increased the PCNA-LI of the distal colon and rectum.	1,2-Dimethylhydrazine	25-28	proliferating cell nuclear antigen	Rattus norvegicus	67-71
9578735-1	1998	Experiments involving the use of 1,2-dimethylhydrazine-induced colonic tumors in rats showed long-term treatment with a newly synthesized drug EDE-10g to inhibit an enzyme of enteric beta-glucuronidase, to suppress carcinogenesis and to prolong lifespan of animals.	1,2-Dimethylhydrazine	33-54	glucuronidase, beta	Rattus norvegicus	183-201
9530618-6	1997	Among the DMH treatment groups, the PCNA-LI of the distal colon in the Wb 5 g/100 g diet group was significantly lower than that in the fiber-free group.	1,2-Dimethylhydrazine	10-13	proliferating cell nuclear antigen	Rattus norvegicus	36-40
9530618-7	1997	The PCNA-LI of the distal colon tended to increase as the amount of Wb supplemented was increased in the DMH-treated groups except for the fiber-free group.	1,2-Dimethylhydrazine	105-108	proliferating cell nuclear antigen	Rattus norvegicus	4-8
9530618-9	1997	In conclusion, the ingestion of Wb diminished the increase in PCNA-LI in rat colorectum induced by DMH injection.	1,2-Dimethylhydrazine	99-102	proliferating cell nuclear antigen	Rattus norvegicus	62-66
9076656-6	1997	Mouse FMO1 expressed in yeast showed activities of thiobenzamide S-oxidation, and NADPH oxidation associated with the S- or N-oxidation of chlorpromazine, N,N-dimethylaniline, N,N-dimethyl-hydrazine, imipramine, nicotine, thioacetamide, thiourea and trimethylamine.	1,2-Dimethylhydrazine	176-198	flavin containing monooxygenase 1	Mus musculus	6-10
9439680-12	1997	In experiment 2, the effect of 24R,25(OH)2vitamin D3 on the alterations in c-fos, c-myc and c-jun oncogene expression in response to DMH administration was examined by northern blot analysis.	1,2-Dimethylhydrazine	133-136	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	75-80
9439680-12	1997	In experiment 2, the effect of 24R,25(OH)2vitamin D3 on the alterations in c-fos, c-myc and c-jun oncogene expression in response to DMH administration was examined by northern blot analysis.	1,2-Dimethylhydrazine	133-136	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	82-87
21533511-10	1997	IgG generated against the cytoplasmic p53 antigen from tumor-bearing rats prevents the carcinogenic effect of 1,2-dimethylhydrazine decreasing significantly the number of tumor-bearing rats in vaccinated group compared with non-vaccinated controls.	1,2-Dimethylhydrazine	110-131	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	38-41
9216672-13	1997	The corncob fiber (15%) treated with the fungus had a significant protective effect against DMH-induced rat colon cancer, even at 15% and this effect was accompanied by the activation of some cellular mechanisms such as apoptosis, PCNA and p53 protein activation.	1,2-Dimethylhydrazine	92-95	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	240-243
9139806-7	1997	However, NPY was expressed at high levels in a new site, the dorsal medial hypothalamic nucleus (DMH).	1,2-Dimethylhydrazine	97-100	neuropeptide Y	Mus musculus	9-12
9139806-8	1997	Expression of NPY in the DMH was also seen in obese MC4-RKO homozygous (-/-) mice, but not in lean heterozygous (+/-) or wild type (+/+) control mice.	1,2-Dimethylhydrazine	25-28	neuropeptide Y	Mus musculus	14-17
9139806-9	1997	This identifies the DMH as a brain region that is functionally altered by the disruption of melanocortinergic signaling and suggests that this nucleus, possibly via elevated NPY expression, may have an etiological role in the melanocortinergic obesity syndrome.	1,2-Dimethylhydrazine	20-23	neuropeptide Y	Mus musculus	174-177
8985466-8	1996	The cathepsin B activity levels in the tumor-bearing mucosa in the groups which received leupeptin or FOY-305 following DMH treatment were both significantly lower than that in the group which received neither protease inhibitor (P = 0.046 and P = 0.0067, respectively).	1,2-Dimethylhydrazine	120-123	cathepsin B	Rattus norvegicus	4-15
7915116-1	1994	Our earlier studies demonstrated that the beta-hydroxy-beta-methylglutaryl coenzyme A (HMG CoA) reductase gene is hypomethylated and overexpressed in hepatic nodules initiated by 1,2-dimethylhydrazine (1,2-DMH).	1,2-Dimethylhydrazine	179-200	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	42-105
21594416-1	1996	We investigated whether spermidine/spermine N-1-acetyltransferase (SSAT) might be a useful marker of 1,2-dimethylhydrazine (DMH)-induced colorectal tumors in rats.	1,2-Dimethylhydrazine	101-122	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	67-71
21594416-1	1996	We investigated whether spermidine/spermine N-1-acetyltransferase (SSAT) might be a useful marker of 1,2-dimethylhydrazine (DMH)-induced colorectal tumors in rats.	1,2-Dimethylhydrazine	124-127	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	67-71
21594416-6	1996	These results indicate that SSAT is an excellent marker of DMH-induced colonic carcinogenesis.	1,2-Dimethylhydrazine	59-62	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	28-32
7586183-0	1995	Mutational and LOH analyses of p53 alleles in colon tumors induced by 1,2-dimethylhydrazine in F1 hybrid mice.	1,2-Dimethylhydrazine	70-91	transformation related protein 53, pseudogene	Mus musculus	31-34
8697942-0	1995	[Inhibition of colorectal carcinoma induced by 1, 2-dimethylhydrazine in mice with tea polyphenols].	1,2-Dimethylhydrazine	47-69	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	83-86
8944029-3	1996	Previously, applying a protocol of 26 injections of 1,2-dimethylhydrazine (DMH), we detected two susceptibility loci, Scc1 and Scc2, on chromosome 2 (refs 4, 5).	1,2-Dimethylhydrazine	52-73	protein tyrosine phosphatase, receptor type, J	Mus musculus	118-122
8944029-3	1996	Previously, applying a protocol of 26 injections of 1,2-dimethylhydrazine (DMH), we detected two susceptibility loci, Scc1 and Scc2, on chromosome 2 (refs 4, 5).	1,2-Dimethylhydrazine	52-73	colon tumor susceptibility 2	Mus musculus	127-131
8944029-3	1996	Previously, applying a protocol of 26 injections of 1,2-dimethylhydrazine (DMH), we detected two susceptibility loci, Scc1 and Scc2, on chromosome 2 (refs 4, 5).	1,2-Dimethylhydrazine	75-78	protein tyrosine phosphatase, receptor type, J	Mus musculus	118-122
8944029-3	1996	Previously, applying a protocol of 26 injections of 1,2-dimethylhydrazine (DMH), we detected two susceptibility loci, Scc1 and Scc2, on chromosome 2 (refs 4, 5).	1,2-Dimethylhydrazine	75-78	colon tumor susceptibility 2	Mus musculus	127-131
21556557-1	1995	A highly sensitive mutation detection method was applied to reveal tarry K-ras alterations in exfoliated intestinal epithelium of Fischer-344 rats during the course of 1,2-dimethylhydrazine (DMH)-induced carcinogenesis.	1,2-Dimethylhydrazine	168-189	KRAS proto-oncogene, GTPase	Rattus norvegicus	73-78
21556557-1	1995	A highly sensitive mutation detection method was applied to reveal tarry K-ras alterations in exfoliated intestinal epithelium of Fischer-344 rats during the course of 1,2-dimethylhydrazine (DMH)-induced carcinogenesis.	1,2-Dimethylhydrazine	191-194	KRAS proto-oncogene, GTPase	Rattus norvegicus	73-78
21556557-3	1995	Analysis of DNA extracted from fresh fecal samples obtained individually showed that proportion of codon 12 K-ras oncogene mutant alleles (G-->A transition at the second position of codon 12) was increased in some rats at 4 weeks and clearly in all rats at 8 weeks after initial DMH injection, i.e. much earlier than the first tumors appeared (14 weeks).	1,2-Dimethylhydrazine	282-285	KRAS proto-oncogene, GTPase	Rattus norvegicus	108-113
7923600-1	1994	3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, pravastatin (Pr) and simvastatin (Si), suppressed 1,2-dimethylhydrazine (DMH)-induced colon cancer development in female ICR mice.	1,2-Dimethylhydrazine	120-141	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	0-57
7923600-1	1994	3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, pravastatin (Pr) and simvastatin (Si), suppressed 1,2-dimethylhydrazine (DMH)-induced colon cancer development in female ICR mice.	1,2-Dimethylhydrazine	143-146	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	0-57
8044776-5	1994	In 1,2-dimethylhydrazine-treated mice the majority of ACF were present in the middle third of the colon, between the two peaks of GALT, but the majority of the tumors were found over the GALT in the distal colon.	1,2-Dimethylhydrazine	3-24	galactose-1-phosphate uridyl transferase	Mus musculus	130-134
8044776-5	1994	In 1,2-dimethylhydrazine-treated mice the majority of ACF were present in the middle third of the colon, between the two peaks of GALT, but the majority of the tumors were found over the GALT in the distal colon.	1,2-Dimethylhydrazine	3-24	galactose-1-phosphate uridyl transferase	Mus musculus	187-191
7844643-6	1994	PAS staining revealed that DMH treatment lowered mucin secretion in crypts, which was substantially lowered by food deprivation.	1,2-Dimethylhydrazine	27-30	solute carrier family 13 member 2	Rattus norvegicus	49-54
7915116-1	1994	Our earlier studies demonstrated that the beta-hydroxy-beta-methylglutaryl coenzyme A (HMG CoA) reductase gene is hypomethylated and overexpressed in hepatic nodules initiated by 1,2-dimethylhydrazine (1,2-DMH).	1,2-Dimethylhydrazine	202-209	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	42-105
7915116-12	1994	Furthermore, an overall similarity was seen in the hypomethylation patterns in the c-myc and c-Ha-ras genes in the DNA of nodules initiated with either 1,2-DMH or AA.	1,2-Dimethylhydrazine	152-159	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	83-88
1934294-2	1991	In the present study, induction and growth characteristics of ACF were investigated in response to a single injection of varying dosages of 1,2-dimethylhydrazine-2HCl (DMH), a colon carcinogen.	1,2-Dimethylhydrazine	168-171	APOBEC1 complementation factor	Rattus norvegicus	62-65
8508505-1	1993	Prior studies from our laboratory have demonstrated that K-ras G to A mutations were detectable in a high percentage of carcinomas which developed in the colons of animals treated with the known colonic procarcinogen, 1,2-dimethyl-hydrazine (DMH).	1,2-Dimethylhydrazine	218-240	KRAS proto-oncogene, GTPase	Rattus norvegicus	57-62
8508505-1	1993	Prior studies from our laboratory have demonstrated that K-ras G to A mutations were detectable in a high percentage of carcinomas which developed in the colons of animals treated with the known colonic procarcinogen, 1,2-dimethyl-hydrazine (DMH).	1,2-Dimethylhydrazine	242-245	KRAS proto-oncogene, GTPase	Rattus norvegicus	57-62
7934958-3	1994	In a test with three mutagens, one potent (ethylnitrosourea) and two weak (1,2-dimethylhydrazine and methyl methanesulphonate), ten weekly treatments induced ten times the frequency of Dlb-1 mutations induced by a single treatment in each case, a result that is consistent with perfect additivity.	1,2-Dimethylhydrazine	75-96	beta-1,4-N-acetyl-galactosaminyl transferase 2	Mus musculus	185-190
7941971-4	1994	However, the population of ir-VP neurons in the DMH shifted to the anterior part of the hypothalamus in 139H-affected hamsters.	1,2-Dimethylhydrazine	48-51	arginine vasopressin	Homo sapiens	30-32
8503280-4	1993	Determination of the nuclear DNA content of cells from DMH-induced mouse colon mucosa (24 wk) indicated that Vit K3 20 or 40 mg.kg-1 group showed lower DNA content (1.92 +/- 0.12 C and 1.91 +/- 0.10 C, respectively) decreased values of percent-over-3C and -4C and narrow distribution range.	1,2-Dimethylhydrazine	55-58	vitrin	Mus musculus	109-112
1335376-5	1992	In concurrent studies, 1,25(OH)2D3 was administered (s.c., 400 ng/rat) prior to, together with and after DMH challenge and the activity of ornithine decarboxylase (ODC), a growth-related DMH-induced enzyme, was determined in colonic cytosols.	1,2-Dimethylhydrazine	187-190	ornithine decarboxylase 1	Rattus norvegicus	139-162
1559225-7	1992	Immunoblotting of subcellular fractions of colonic mucosa from control and 1,2-dimethylhydrazine treated rats demonstrated the presence of protein kinase C alpha, but no detectable beta and gamma forms.	1,2-Dimethylhydrazine	75-96	protein kinase C, alpha	Rattus norvegicus	139-161
1934294-5	1991	Number of ACF increased with increasing dosages of DMH plateauing at 100 mg/kg.	1,2-Dimethylhydrazine	51-54	APOBEC1 complementation factor	Rattus norvegicus	10-13
1868452-0	1991	K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors: effects of supplemental dietary calcium and vitamin D deficiency.	1,2-Dimethylhydrazine	19-40	KRAS proto-oncogene, GTPase	Rattus norvegicus	0-5
2253241-4	1990	Chronic administration of 1,2-dimethylhydrazine (20 mg/kg/week s.c. for 10 weeks) induced Dlb-1 mutants, whereas administration of a single dose did not.	1,2-Dimethylhydrazine	26-47	beta-1,4-N-acetyl-galactosaminyl transferase 2	Mus musculus	90-95
2009526-2	1991	We investigated the isoforms of ODC during 1,2-dimethylhydrazine-induced colon carcinogenesis and in human colon tumors.	1,2-Dimethylhydrazine	43-64	ornithine decarboxylase 1	Homo sapiens	32-35
2009526-7	1991	ODC activity in both 1,2-dimethylhydrazine-induced and human colon tumors was significantly higher compared with the normal colon mucosa.	1,2-Dimethylhydrazine	21-42	ornithine decarboxylase 1	Homo sapiens	0-3
1991846-0	1991	Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa.	1,2-Dimethylhydrazine	43-64	KRAS proto-oncogene, GTPase	Rattus norvegicus	17-22
1991846-1	1991	These experiments were conducted to determine whether point mutations activating K-ras or H-ras oncogenes, induced by the procarcinogen 1,2-dimethylhydrazine (DMH), were detectable in preneoplastic or neoplastic rat colonic mucosa.	1,2-Dimethylhydrazine	136-157	KRAS proto-oncogene, GTPase	Rattus norvegicus	81-86
1991846-1	1991	These experiments were conducted to determine whether point mutations activating K-ras or H-ras oncogenes, induced by the procarcinogen 1,2-dimethylhydrazine (DMH), were detectable in preneoplastic or neoplastic rat colonic mucosa.	1,2-Dimethylhydrazine	136-157	HRas proto-oncogene, GTPase	Rattus norvegicus	90-95
1991846-1	1991	These experiments were conducted to determine whether point mutations activating K-ras or H-ras oncogenes, induced by the procarcinogen 1,2-dimethylhydrazine (DMH), were detectable in preneoplastic or neoplastic rat colonic mucosa.	1,2-Dimethylhydrazine	159-162	KRAS proto-oncogene, GTPase	Rattus norvegicus	81-86
1991846-1	1991	These experiments were conducted to determine whether point mutations activating K-ras or H-ras oncogenes, induced by the procarcinogen 1,2-dimethylhydrazine (DMH), were detectable in preneoplastic or neoplastic rat colonic mucosa.	1,2-Dimethylhydrazine	159-162	HRas proto-oncogene, GTPase	Rattus norvegicus	90-95
1991846-5	1991	While no H-ras mutations were detectable in any group, K-ras (G to A) mutations were found in 66% of DMH-induced colon carcinomas.	1,2-Dimethylhydrazine	101-104	KRAS proto-oncogene, GTPase	Rattus norvegicus	55-60
2253241-8	1990	The activities of 1,2-dimethylhydrazine, dimethylnitrosamine, and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in the Dlb-1 assay more accurately reflect their carcinogenic potential than do many in vitro bioassays.	1,2-Dimethylhydrazine	18-39	beta-1,4-N-acetyl-galactosaminyl transferase 2	Mus musculus	119-124
33233290-3	2020	IL-10-/- mice were induced to carcinogenesis with 1,2-dimethylhydrazine and divided into two experimental groups: control and synbiotic.	1,2-Dimethylhydrazine	50-71	interleukin 10	Mus musculus	0-5
2308874-4	1990	This short-term exposure to DMH increased colonic ornithine decarboxylase (ODC) activity and the mass of cecal contents.	1,2-Dimethylhydrazine	28-31	ornithine decarboxylase 1	Rattus norvegicus	50-73
2308874-4	1990	This short-term exposure to DMH increased colonic ornithine decarboxylase (ODC) activity and the mass of cecal contents.	1,2-Dimethylhydrazine	28-31	ornithine decarboxylase 1	Rattus norvegicus	75-78
2265465-0	1990	Effect of polyamine oxidase inhibition on the colonic malignant transformation process induced by 1,2-dimethylhydrazine.	1,2-Dimethylhydrazine	98-119	polyamine oxidase	Rattus norvegicus	10-27
2400995-11	1990	In six of the 50 DMH-treated rats, only LAM expressed carcinoembryonic antigen.	1,2-Dimethylhydrazine	17-20	CEA cell adhesion molecule 20	Rattus norvegicus	54-78
2118939-3	1990	1) Thymidylate synthetase (TS), DNA-synthesizing enzyme in de novo pathway of pyrimidine metabolism, increased to approximately 7-fold that of normal control colon in DMH-induced colon carcinomas in activity, but was markedly reduced to 48% of that in the carcinomas by administration of UFT.	1,2-Dimethylhydrazine	167-170	thymidylate synthetase	Rattus norvegicus	3-25
2369091-4	1990	The enhanced responses of ODC and of CK-II to DMH proceeded the actual polyp and tumor formation.	1,2-Dimethylhydrazine	46-49	ornithine decarboxylase 1	Rattus norvegicus	26-29
2403521-7	1990	Relative abundance of IGF-II mRNA in control hypothalami was VH much greater than cortex greater than or equal to LtH greater than DMH.	1,2-Dimethylhydrazine	131-134	insulin-like growth factor 2	Rattus norvegicus	22-28
33818196-5	2022	The DMH group exhibited a significant increase in the gene and protein expression of activin A as well as MDA and NO levels in tissues.	1,2-Dimethylhydrazine	4-7	inhibin subunit beta A	Rattus norvegicus	85-94
33818196-7	2022	Administration of Hsd significantly upregulated Smad4 and activin A gene expressions in both the DMH + Hsd and DMH followed by Hsd groups.	1,2-Dimethylhydrazine	97-100	SMAD family member 4	Rattus norvegicus	48-53
33818196-7	2022	Administration of Hsd significantly upregulated Smad4 and activin A gene expressions in both the DMH + Hsd and DMH followed by Hsd groups.	1,2-Dimethylhydrazine	97-100	inhibin subunit beta A	Rattus norvegicus	58-67
33818196-7	2022	Administration of Hsd significantly upregulated Smad4 and activin A gene expressions in both the DMH + Hsd and DMH followed by Hsd groups.	1,2-Dimethylhydrazine	111-114	inhibin subunit beta A	Rattus norvegicus	58-67
28628036-4	2017	First, we found that ArcN NPY/AgRP fibers closely appose PVN and DMH presympathetic neurons.	1,2-Dimethylhydrazine	65-68	neuropeptide Y	Mus musculus	26-29
28628036-4	2017	First, we found that ArcN NPY/AgRP fibers closely appose PVN and DMH presympathetic neurons.	1,2-Dimethylhydrazine	65-68	agouti related neuropeptide	Mus musculus	30-34
28628036-8	2017	Considering that chronic obesity decreases ArcN NPY content, we propose that the ArcN NPY neuropathway to the PVN and DMH is pivotal in obesity-induced elevations in SNA.	1,2-Dimethylhydrazine	118-121	neuropeptide Y	Mus musculus	48-51
28628036-8	2017	Considering that chronic obesity decreases ArcN NPY content, we propose that the ArcN NPY neuropathway to the PVN and DMH is pivotal in obesity-induced elevations in SNA.	1,2-Dimethylhydrazine	118-121	neuropeptide Y	Mus musculus	86-89
34655712-5	2021	We therefore investigated whether intra-DMH administration of CCK, with or without inhibitors of the CCK2 receptor and nitric oxide signaling pathways, affects food intake in young, male, fasted Sprague-Dawley rats.	1,2-Dimethylhydrazine	40-43	cholecystokinin	Rattus norvegicus	62-65
34655712-3	2021	At the synaptic level, CCK has been shown to inhibit putative orexigenic DMH neurons in young male rats by increasing GABA release onto these neurons via a CCK2 receptor and nitric oxide-dependent pathway.	1,2-Dimethylhydrazine	73-76	cholecystokinin	Rattus norvegicus	23-26
34754156-12	2021	Cold exposure and capsaicin significantly increased the protein levels of COL I, elastin, and LOXL2 along with increases in their mRNA levels in the colon tissues compared with the DMH group, while COL III did not show a significant difference.	1,2-Dimethylhydrazine	181-184	elastin	Rattus norvegicus	81-88
34754156-12	2021	Cold exposure and capsaicin significantly increased the protein levels of COL I, elastin, and LOXL2 along with increases in their mRNA levels in the colon tissues compared with the DMH group, while COL III did not show a significant difference.	1,2-Dimethylhydrazine	181-184	lysyl oxidase-like 2	Rattus norvegicus	94-99
34754156-13	2021	Furthermore, in immunohistochemical evaluations, MMP1, MMP2, MMP9, and TIMP1 staining increased in the cold exposure and capsaicin group compared with the DMH group.	1,2-Dimethylhydrazine	155-158	matrix metallopeptidase 1	Rattus norvegicus	49-53
34754156-13	2021	Furthermore, in immunohistochemical evaluations, MMP1, MMP2, MMP9, and TIMP1 staining increased in the cold exposure and capsaicin group compared with the DMH group.	1,2-Dimethylhydrazine	155-158	matrix metallopeptidase 2	Rattus norvegicus	55-59
34754156-13	2021	Furthermore, in immunohistochemical evaluations, MMP1, MMP2, MMP9, and TIMP1 staining increased in the cold exposure and capsaicin group compared with the DMH group.	1,2-Dimethylhydrazine	155-158	matrix metallopeptidase 9	Rattus norvegicus	61-65
34754156-13	2021	Furthermore, in immunohistochemical evaluations, MMP1, MMP2, MMP9, and TIMP1 staining increased in the cold exposure and capsaicin group compared with the DMH group.	1,2-Dimethylhydrazine	155-158	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	71-76
34655712-10	2021	Here we show that intra-DMH administration of CCK suppresses food intake and body weight in young rats.	1,2-Dimethylhydrazine	24-27	cholecystokinin	Rattus norvegicus	46-49
34101933-5	2021	RESULTS: Low levels of GRK2 were able to sustain STZ-induced pain in DMH rats.	1,2-Dimethylhydrazine	69-72	G protein-coupled receptor kinase 2	Rattus norvegicus	23-27
34101933-6	2021	Intrathecal injection of AAV-GRK2 vector upregulated GRK2 expression, providing pain rain to rats with DMH.	1,2-Dimethylhydrazine	103-106	G protein-coupled receptor kinase 2	Rattus norvegicus	29-33
34101933-6	2021	Intrathecal injection of AAV-GRK2 vector upregulated GRK2 expression, providing pain rain to rats with DMH.	1,2-Dimethylhydrazine	103-106	G protein-coupled receptor kinase 2	Rattus norvegicus	53-57
34101933-7	2021	With an increase in DMH duration, there was a decrease in paw withdrawal threshold (PWT) value, aggravating the pain, resulting in a decreasing pattern in GRK2 protein expression over time, whereas Epac1 protein expression showed an opposite trend.	1,2-Dimethylhydrazine	20-23	G protein-coupled receptor kinase 2	Rattus norvegicus	155-159
34101933-7	2021	With an increase in DMH duration, there was a decrease in paw withdrawal threshold (PWT) value, aggravating the pain, resulting in a decreasing pattern in GRK2 protein expression over time, whereas Epac1 protein expression showed an opposite trend.	1,2-Dimethylhydrazine	20-23	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	198-203
34101933-8	2021	CONCLUSION: GRK2 expression regulated DMH progression and is expected to play a role in the development of targeted therapy for DMH.	1,2-Dimethylhydrazine	38-41	G protein-coupled receptor kinase 2	Rattus norvegicus	12-16
34101933-8	2021	CONCLUSION: GRK2 expression regulated DMH progression and is expected to play a role in the development of targeted therapy for DMH.	1,2-Dimethylhydrazine	128-131	G protein-coupled receptor kinase 2	Rattus norvegicus	12-16
34101933-9	2021	GRK2 and Epac1 expressions play a vital role in maintaining pain in DMH rats.	1,2-Dimethylhydrazine	68-71	G protein-coupled receptor kinase 2	Rattus norvegicus	0-4
34101933-9	2021	GRK2 and Epac1 expressions play a vital role in maintaining pain in DMH rats.	1,2-Dimethylhydrazine	68-71	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	9-14
2752519-2	1989	We now report a similar antineoplastic action of InsP6 in CD-1 mice injected with 1,2-dimethylhydrazine (DMH).	1,2-Dimethylhydrazine	82-103	inositol hexaphosphate kinase 1	Mus musculus	49-54
34440274-2	2021	The affinity of cannabinoids for their CB1 and CB2 metabotropic receptors is dramatically affected by a combination of alpha-branching and elongation of their alkyl substituent, a maneuver exemplified by the n-pentyl -> alpha,alpha-dimethylheptyl (DMH) swap.	1,2-Dimethylhydrazine	248-251	cannabinoid receptor 1	Homo sapiens	39-42
34440274-2	2021	The affinity of cannabinoids for their CB1 and CB2 metabotropic receptors is dramatically affected by a combination of alpha-branching and elongation of their alkyl substituent, a maneuver exemplified by the n-pentyl -> alpha,alpha-dimethylheptyl (DMH) swap.	1,2-Dimethylhydrazine	248-251	cannabinoid receptor 2	Homo sapiens	47-50
34440274-5	2021	Surprisingly, the DMH chain promoted a shift in the selectivity toward TRPA1, a target involved in pain and inflammatory diseases, in all investigated compounds.	1,2-Dimethylhydrazine	18-21	transient receptor potential cation channel subfamily A member 1	Homo sapiens	71-76
34440274-6	2021	A comparative study of the putative binding modes at TRPA1 between DMH-CBC (8b), the most active compound within the series, and CBC (8a) was carried out by molecular docking, allowing the rationalization of their activity in terms of structure-activity relationships.	1,2-Dimethylhydrazine	67-70	transient receptor potential cation channel subfamily A member 1	Homo sapiens	53-58
35299250-13	2022	Immunohistochemical analysis revealed significantly lower levels of expression of COX-2 (86%) and PCNA (83%) in the colon of rats treated with DEHE plus DMH, concerning those treated with the carcinogen.	1,2-Dimethylhydrazine	153-156	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	82-87
35299250-13	2022	Immunohistochemical analysis revealed significantly lower levels of expression of COX-2 (86%) and PCNA (83%) in the colon of rats treated with DEHE plus DMH, concerning those treated with the carcinogen.	1,2-Dimethylhydrazine	153-156	proliferating cell nuclear antigen	Rattus norvegicus	98-102
35163194-7	2022	Then, using non-specific and specific apoptosis, we found that lesions of whole DMH neurons and DMH gamma-aminobutyric acid (GABA)-ergic neurons induced by caspase-3 virus aggravated the fluctuation of core body temperature after warm exposure and attenuated the change in sleep-wake behaviors during cold and warm exposure.	1,2-Dimethylhydrazine	96-99	caspase 3	Mus musculus	156-165
34638619-5	2021	In the colonic tumors of rats with DMH-induced carcinogenesis, the expression of claudin-3 and -4 was significantly increased compared to controls.	1,2-Dimethylhydrazine	35-38	claudin 3	Rattus norvegicus	81-97
34638619-7	2021	The increase of claudin-4 in rat colon after chronic DMH exposure was consistent with the acute effect of DMH on IPEC-J2 cells, which may indicate an essential role of this protein in colorectal cancer development.	1,2-Dimethylhydrazine	53-56	claudin 4	Rattus norvegicus	16-25
34638619-7	2021	The increase of claudin-4 in rat colon after chronic DMH exposure was consistent with the acute effect of DMH on IPEC-J2 cells, which may indicate an essential role of this protein in colorectal cancer development.	1,2-Dimethylhydrazine	106-109	claudin 4	Rattus norvegicus	16-25
35203618-4	2022	DMH treatment decreased microhematocrit values and IL-6, ghrelin, and myostatin serum levels.	1,2-Dimethylhydrazine	0-3	interleukin 6	Rattus norvegicus	51-55
35203618-4	2022	DMH treatment decreased microhematocrit values and IL-6, ghrelin, and myostatin serum levels.	1,2-Dimethylhydrazine	0-3	ghrelin and obestatin prepropeptide	Rattus norvegicus	57-64
2689774-9	1989	UEA-I- and PNA-binding to luminal surface and UEA-I-binding to the mucin of distal colonic mucosa from DMH-treated rats was similar to that observed in rat fetal colon suggesting a reappearance of a fetal-type pattern.	1,2-Dimethylhydrazine	103-106	solute carrier family 13 member 2	Rattus norvegicus	67-72
2593308-3	1989	ODC activities (pmoles 14CO2/hr/mg prot, mean +/- SD) in colon tissue were 122 +/- 10.6 (n = 6) in DMH with theophylline group, 28.3 +/- 2.13 (n = 8) in DMH alone group, 21.3 +/- 1.67 (n = 6) in control group respectively.	1,2-Dimethylhydrazine	99-102	ornithine decarboxylase, structural 1	Mus musculus	0-3
2593308-3	1989	ODC activities (pmoles 14CO2/hr/mg prot, mean +/- SD) in colon tissue were 122 +/- 10.6 (n = 6) in DMH with theophylline group, 28.3 +/- 2.13 (n = 8) in DMH alone group, 21.3 +/- 1.67 (n = 6) in control group respectively.	1,2-Dimethylhydrazine	153-156	ornithine decarboxylase, structural 1	Mus musculus	0-3
2752519-2	1989	We now report a similar antineoplastic action of InsP6 in CD-1 mice injected with 1,2-dimethylhydrazine (DMH).	1,2-Dimethylhydrazine	82-103	CD1 antigen complex	Mus musculus	58-62
2752519-2	1989	We now report a similar antineoplastic action of InsP6 in CD-1 mice injected with 1,2-dimethylhydrazine (DMH).	1,2-Dimethylhydrazine	105-108	inositol hexaphosphate kinase 1	Mus musculus	49-54
2752519-2	1989	We now report a similar antineoplastic action of InsP6 in CD-1 mice injected with 1,2-dimethylhydrazine (DMH).	1,2-Dimethylhydrazine	105-108	CD1 antigen complex	Mus musculus	58-62
2752519-4	1989	LIC induced by DMH (15 mg/kg/week x 13) in mice given a mixture of 1% InsP6 + 1% Ins show a significant reduction (P less than 0.005) in LIC prevalence over InsP6 treatment.	1,2-Dimethylhydrazine	15-18	inositol hexaphosphate kinase 1	Mus musculus	70-75
2752519-4	1989	LIC induced by DMH (15 mg/kg/week x 13) in mice given a mixture of 1% InsP6 + 1% Ins show a significant reduction (P less than 0.005) in LIC prevalence over InsP6 treatment.	1,2-Dimethylhydrazine	15-18	inositol hexaphosphate kinase 1	Mus musculus	157-162
2847657-2	1988	Kinetic analysis and the study of the effects of superoxide dismutase, catalase, and azide on reaction rates indicate that SDMH oxidation is primarily dependent on ferric hemoglobin and autoxidatively formed H2O2.	1,2-Dimethylhydrazine	123-127	catalase	Homo sapiens	71-79
2894240-3	1988	In contrast, the induction of GGT-positive foci by another methylating agent, 1,2-dimethylhydrazine, was enhanced by ABA in Wistar rats, but not affected in Fischer rats.	1,2-Dimethylhydrazine	78-99	gamma-glutamyltransferase 1	Rattus norvegicus	30-33
3130359-1	1988	Using NIH3T3 cell transfection assay, activated c-K-ras was detected in two cell lines, TRb and TSb, obtained from a single colon adenocarcinoma induced in a rat by 1,2-dimethylhydrazine.	1,2-Dimethylhydrazine	165-186	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	48-55
3130359-1	1988	Using NIH3T3 cell transfection assay, activated c-K-ras was detected in two cell lines, TRb and TSb, obtained from a single colon adenocarcinoma induced in a rat by 1,2-dimethylhydrazine.	1,2-Dimethylhydrazine	165-186	apoptosis antagonizing transcription factor	Mus musculus	88-91
3501927-2	1987	In Western blotting, high levels of c-Ha-ras p 21 were found in serially transplantable rat duodenal carcinomas induced by MNNG and rat colon carcinomas induced by DMH.	1,2-Dimethylhydrazine	164-167	KRAS proto-oncogene, GTPase	Rattus norvegicus	45-49
3163916-1	1988	1,2-Dimethylhydrazine-induced large bowel tumors in adult male rats contained significantly lower levels of xanthine oxidase and xanthine dehydrogenase activities when compared to levels in normal intestinal tissue.	1,2-Dimethylhydrazine	0-21	xanthine dehydrogenase	Rattus norvegicus	129-151
3501927-6	1987	These findings suggest that c-Ha-ras p 21 expression plays an important role in tumor proliferation, invasion and metastasis of DMH-induced colon carcinoma.	1,2-Dimethylhydrazine	128-131	KRAS proto-oncogene, GTPase	Rattus norvegicus	37-41
3105903-0	1986	Thymidylate synthetase and thymidine kinase activities in DMH-induced colon carcinomas in rats and effects of UFT.	1,2-Dimethylhydrazine	58-61	thymidylate synthetase	Rattus norvegicus	0-22
4006053-0	1985	Effect of exogenous beta-glucuronidase on the carcinogenicity of 1,2-dimethylhydrazine in rats: evidence that carcinogenic intermediates form conjugates and act through their subsequent enzymatic release.	1,2-Dimethylhydrazine	65-86	glucuronidase, beta	Rattus norvegicus	20-38
4006053-5	1985	The broadening of the spectrum of malignant tumours produced in DMH-treated rats by administration of beta-glucuronidase indicates that the carcinogenic effect of DMH may be exerted through formation of comparatively stable conjugates of its metabolites and their enzymic release in target tissues.	1,2-Dimethylhydrazine	64-67	glucuronidase, beta	Rattus norvegicus	102-120
4006053-5	1985	The broadening of the spectrum of malignant tumours produced in DMH-treated rats by administration of beta-glucuronidase indicates that the carcinogenic effect of DMH may be exerted through formation of comparatively stable conjugates of its metabolites and their enzymic release in target tissues.	1,2-Dimethylhydrazine	163-166	glucuronidase, beta	Rattus norvegicus	102-120
6140086-1	1983	Feeding male Fischer F-344 rats for 5 weeks a diet containing 1% orotic acid, a precursor for pyrimidine nucleotide biosynthesis, resulted in an increased incidence of gamma-glutamyltransferase (EC 2.3.2.2) positive foci induced by chemical carcinogens including 1,2-dimethylhydrazine, diethylnitrosamine, benzo[a]pyrene, and aflatoxin B1.	1,2-Dimethylhydrazine	263-284	gamma-glutamyltransferase 1	Rattus norvegicus	168-193
3891634-1	1985	In a previous communication, carcinoembryonic antigen (CEA) of rat, which is an analogue to human CEA, was demonstrated in gastrointestinal adenocarcinomas induced in inbred Fischer rats by injection of 1,2-dimethylhydrazine.	1,2-Dimethylhydrazine	203-224	CEA cell adhesion molecule 20	Rattus norvegicus	29-53
3891634-1	1985	In a previous communication, carcinoembryonic antigen (CEA) of rat, which is an analogue to human CEA, was demonstrated in gastrointestinal adenocarcinomas induced in inbred Fischer rats by injection of 1,2-dimethylhydrazine.	1,2-Dimethylhydrazine	203-224	CEA cell adhesion molecule 20	Rattus norvegicus	55-58
3891634-1	1985	In a previous communication, carcinoembryonic antigen (CEA) of rat, which is an analogue to human CEA, was demonstrated in gastrointestinal adenocarcinomas induced in inbred Fischer rats by injection of 1,2-dimethylhydrazine.	1,2-Dimethylhydrazine	203-224	CEA cell adhesion molecule 3	Homo sapiens	98-101
4069291-0	1985	Changes in tissue and serum activity of cathepsin B-like cysteine proteinase during colorectal carcinogenesis by 1,2-dimethylhydrazine in mice.	1,2-Dimethylhydrazine	113-134	cathepsin B	Mus musculus	40-51
4069291-0	1985	Changes in tissue and serum activity of cathepsin B-like cysteine proteinase during colorectal carcinogenesis by 1,2-dimethylhydrazine in mice.	1,2-Dimethylhydrazine	113-134	calpain 2	Mus musculus	57-76
4069291-1	1985	The activity of cathepsin B-like cysteine proteinase in the mice colon was studied during carcinogenesis induced by 1,2-dimethylhydrazine dihydrochloride (DMH).	1,2-Dimethylhydrazine	155-158	cathepsin B	Mus musculus	16-27
4069291-1	1985	The activity of cathepsin B-like cysteine proteinase in the mice colon was studied during carcinogenesis induced by 1,2-dimethylhydrazine dihydrochloride (DMH).	1,2-Dimethylhydrazine	155-158	calpain 2	Mus musculus	33-52
6632908-0	1983	Induction of colon mucosal beta-glucuronidase production as a mechanism for 1,2-dimethylhydrazine colon carcinogenesis.	1,2-Dimethylhydrazine	76-97	glucuronidase, beta	Rattus norvegicus	27-45
6283784-4	1982	The carcinomas induced by DMH were classified mainly into mucin producing carcinomas and non-mucin producing ones.	1,2-Dimethylhydrazine	26-29	solute carrier family 13 member 2	Rattus norvegicus	58-63
6307537-2	1983	With single doses of B[a]P or 1,2-DMH during the feeding of the CLD diet for 3 weeks, the number of foci of hepatocytes positive for gamma-glutamyl transferase is approximately the same as with the same dose of each carcinogen given after partial hepatectomy.	1,2-Dimethylhydrazine	30-37	gamma-glutamyltransferase 1	Rattus norvegicus	133-159
6887935-14	1983	Thus, DMH-induced colon carcinomas in W/Fu rats arise at sites containing preexisting LP-GALT with associated specialized epithelium.	1,2-Dimethylhydrazine	6-9	galactose-1-phosphate uridylyltransferase	Rattus norvegicus	89-93
6283784-4	1982	The carcinomas induced by DMH were classified mainly into mucin producing carcinomas and non-mucin producing ones.	1,2-Dimethylhydrazine	26-29	solute carrier family 13 member 2	Rattus norvegicus	93-98
33753517-0	2021	Restriction of food intake by PPP1R17-expressing neurons in the DMH.	1,2-Dimethylhydrazine	64-67	protein phosphatase 1, regulatory subunit 17	Mus musculus	30-37
7117750-0	1982	Region-specific patterns of mucin reaction demonstrated by paradoxical concanavalin A-staining in normal colonic epithelium and in colorectal cancers induced in rats by 1,2-dimethylhydrazine.	1,2-Dimethylhydrazine	169-190	solute carrier family 13 member 2	Rattus norvegicus	28-33
7117750-1	1982	The histochemistry of mucin in normal large intestine and in experimental colorectal cancers induced in Wistar rats with 1,2-dimethylhydrazine was analyzed by modifications of the concanavalin A-horseradish peroxidase method (paradoxical concanavalin A-staining) and high-iron diamine-Alcian blue (pH 2.5) staining (HID-AB).	1,2-Dimethylhydrazine	121-142	solute carrier family 13 member 2	Rattus norvegicus	22-27
7306970-16	1981	The effects of selenium and DMH treatments on glutathione peroxidase and beta-glucuronidase activities and on sialic acid are presented.	1,2-Dimethylhydrazine	28-31	glucuronidase, beta	Rattus norvegicus	73-91
650715-3	1978	In the present study, CS2 itself was found to inhibit DMH-induced neoplasia of the large bowel in female CF1 mice.	1,2-Dimethylhydrazine	54-57	calsyntenin 2	Mus musculus	22-25
4852176-3	1974	In rats injected with 1,2-dimethylhydrazine, a many fold increase in N-acetyl-beta-D-glucosaminidase, N-acetyl-beta-D-galactosaminidase, beta-D-galactosidase and alpha-L-fucosidase was found in colonic tumours and colonic mucosa.	1,2-Dimethylhydrazine	22-43	O-GlcNAcase	Rattus norvegicus	69-100
884265-1	1977	Carcinoembryonal antigen (CEA) was shown to be present in 70% of rats with tumours of the large intestine induced with 1,2-dimethyl-hydrazine and in rats with posttraumatic mucosa regeneration of the same organ.	1,2-Dimethylhydrazine	119-141	carcinoembryonic antigen gene family 4	Rattus norvegicus	0-24
884265-1	1977	Carcinoembryonal antigen (CEA) was shown to be present in 70% of rats with tumours of the large intestine induced with 1,2-dimethyl-hydrazine and in rats with posttraumatic mucosa regeneration of the same organ.	1,2-Dimethylhydrazine	119-141	carcinoembryonic antigen gene family 4	Rattus norvegicus	26-29
18126-0	1977	Gamma glutamyl transpeptidase in colon cancer induced by 1,2-dimethylhydrazine.	1,2-Dimethylhydrazine	57-78	gamma-glutamyltransferase 1	Rattus norvegicus	0-29
18126-4	1977	Colon adenocarcinoma induced by 1,2-dimethylhydrazine were found to have a much higher GTase activity than the homologous normal tissue.	1,2-Dimethylhydrazine	32-53	gamma-glutamyltransferase 1	Rattus norvegicus	87-92
33727058-10	2021	These findings suggest that NCX activation may underlie orexin-A-induced depolarization in the majority of orexin-responsive DMH neurons.	1,2-Dimethylhydrazine	125-128	solute carrier family 8 member A1	Rattus norvegicus	28-31
33727058-10	2021	These findings suggest that NCX activation may underlie orexin-A-induced depolarization in the majority of orexin-responsive DMH neurons.	1,2-Dimethylhydrazine	125-128	hypocretin neuropeptide precursor	Rattus norvegicus	56-64
33727058-10	2021	These findings suggest that NCX activation may underlie orexin-A-induced depolarization in the majority of orexin-responsive DMH neurons.	1,2-Dimethylhydrazine	125-128	hypocretin neuropeptide precursor	Rattus norvegicus	56-62
33727058-11	2021	Of 19 RVLM-projecting DMH neurons identified by retrograde labeling, 17 (90%) were orexin-A responsive.	1,2-Dimethylhydrazine	22-25	hypocretin neuropeptide precursor	Rattus norvegicus	83-91
33866645-4	2021	Administration of probiotics in both AdF10 + DMH-treated and LGG + DMH-treated groups downregulated DMH induced a rise in lipid peroxide (LPO), glutathione reductase (GR) activity, and increased the diminished glutathione reduced (GSH) content and catalase (CAT), glutathione-transferase (GST), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities.	1,2-Dimethylhydrazine	67-70	glutathione peroxidase	Lactobacillus rhamnosus GG	327-349
33866645-4	2021	Administration of probiotics in both AdF10 + DMH-treated and LGG + DMH-treated groups downregulated DMH induced a rise in lipid peroxide (LPO), glutathione reductase (GR) activity, and increased the diminished glutathione reduced (GSH) content and catalase (CAT), glutathione-transferase (GST), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities.	1,2-Dimethylhydrazine	67-70	glutathione peroxidase	Lactobacillus rhamnosus GG	351-354
33866645-4	2021	Administration of probiotics in both AdF10 + DMH-treated and LGG + DMH-treated groups downregulated DMH induced a rise in lipid peroxide (LPO), glutathione reductase (GR) activity, and increased the diminished glutathione reduced (GSH) content and catalase (CAT), glutathione-transferase (GST), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities.	1,2-Dimethylhydrazine	67-70	glutathione peroxidase	Lactobacillus rhamnosus GG	327-349
33866645-4	2021	Administration of probiotics in both AdF10 + DMH-treated and LGG + DMH-treated groups downregulated DMH induced a rise in lipid peroxide (LPO), glutathione reductase (GR) activity, and increased the diminished glutathione reduced (GSH) content and catalase (CAT), glutathione-transferase (GST), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities.	1,2-Dimethylhydrazine	67-70	glutathione peroxidase	Lactobacillus rhamnosus GG	351-354
33754881-5	2021	Our results indicate that DMH administration increased the oxidative stress (MDA) and depleted the glutathione and antioxidant enzyme activities (SOD, CAT, GR, GST and GPx) which was significantly ameliorated by EGCG treatment.	1,2-Dimethylhydrazine	26-29	catalase	Rattus norvegicus	151-154
33754881-5	2021	Our results indicate that DMH administration increased the oxidative stress (MDA) and depleted the glutathione and antioxidant enzyme activities (SOD, CAT, GR, GST and GPx) which was significantly ameliorated by EGCG treatment.	1,2-Dimethylhydrazine	26-29	glutathione-disulfide reductase	Rattus norvegicus	156-158
33754881-6	2021	Additionally DMH treatment upregulated inflammatory markers expression (NF-kappaB, COX-2 and IL-6) and enhanced mucosal damage in the colon.	1,2-Dimethylhydrazine	13-16	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	83-88
33754881-6	2021	Additionally DMH treatment upregulated inflammatory markers expression (NF-kappaB, COX-2 and IL-6) and enhanced mucosal damage in the colon.	1,2-Dimethylhydrazine	13-16	interleukin 6	Rattus norvegicus	93-97
32989804-4	2021	Dietary EtnGpl-suppressed DMH-induced aberrant crypt with one foci (AC1) and total ACF formation (P < 0.05).	1,2-Dimethylhydrazine	26-29	phospholipase A and acyltransferase 1	Mus musculus	68-71
33445792-10	2021	It significantly inhibited hepatic glutathione-S-transferase positive foci formation induced by diethylnitrosamine and 1,2-dimethylhydrazine by suppression of hepatocyte proliferation and induction of apoptosis.	1,2-Dimethylhydrazine	119-140	hematopoietic prostaglandin D synthase	Rattus norvegicus	35-60
33249075-7	2021	DMH+DSS group showed a significant (P < 0.05) increase in the levels of AREG (2386+-18 vs 1377+-10 pg/ml), CXCL1 (18+-0.9 vs 6+-0.83 <mu>g/ml), MMP-9 (1355+-88 vs 452+-7 pg/ml) compared to normal rats.	1,2-Dimethylhydrazine	0-3	amphiregulin	Rattus norvegicus	72-76
33249075-7	2021	DMH+DSS group showed a significant (P < 0.05) increase in the levels of AREG (2386+-18 vs 1377+-10 pg/ml), CXCL1 (18+-0.9 vs 6+-0.83 <mu>g/ml), MMP-9 (1355+-88 vs 452+-7 pg/ml) compared to normal rats.	1,2-Dimethylhydrazine	0-3	C-X-C motif chemokine ligand 1	Rattus norvegicus	107-112
33249075-7	2021	DMH+DSS group showed a significant (P < 0.05) increase in the levels of AREG (2386+-18 vs 1377+-10 pg/ml), CXCL1 (18+-0.9 vs 6+-0.83 <mu>g/ml), MMP-9 (1355+-88 vs 452+-7 pg/ml) compared to normal rats.	1,2-Dimethylhydrazine	0-3	matrix metallopeptidase 9	Rattus norvegicus	144-149
33584175-7	2020	A similar proportion of DMH neurons containing TH-IR expressed RXFP3-related tdTomato fluorescence, consistent with a possible RXFP3-mediated regulation of stress and neuroendocrine circuits.	1,2-Dimethylhydrazine	24-27	relaxin family peptide receptor 3	Mus musculus	63-68
33289288-5	2020	Results demonstrated that HD inhibited DMH mediated oxidative damage by diminishing the level of peroxidation of lipids and increasing the activity of superoxide dismutase, catalase, reduced glutathione, glutathione peroxidase, glutathione-s-transferase, and glutathione reductase.	1,2-Dimethylhydrazine	39-42	hematopoietic prostaglandin D synthase	Rattus norvegicus	228-253
33259012-8	2020	The exposure of DMH-treated mice to chronic stress counteracted the inflammatory effect of DMH and maintained ODC homeostasis.	1,2-Dimethylhydrazine	16-19	ornithine decarboxylase, structural 1	Mus musculus	110-113
33259012-9	2020	In early phase of carcinogenesis, the exposure of DMH-treated mice to chronic stress had a positive effect against colon inflammation and maintained ODC homeostasis.	1,2-Dimethylhydrazine	50-53	ornithine decarboxylase, structural 1	Mus musculus	149-152
33387432-12	2020	The results of the research showed that the introduction of 1,2- dimethylhydrazine to animals is accompanied by a change in the cytokine profile, increases the level of pro-inflammatory IL-6 and decreases the level of anti-inflammatory IL-4.	1,2-Dimethylhydrazine	60-82	interleukin 6	Rattus norvegicus	186-190
33387432-12	2020	The results of the research showed that the introduction of 1,2- dimethylhydrazine to animals is accompanied by a change in the cytokine profile, increases the level of pro-inflammatory IL-6 and decreases the level of anti-inflammatory IL-4.	1,2-Dimethylhydrazine	60-82	interleukin 4	Rattus norvegicus	236-240
33259012-7	2020	The short-term exposure to DMH triggered colon inflammation, initiated colon carcinogenesis and increased ODC expression; meanwhile, the exposure to chronic stress activated the hypothalamic-pituitary-adrenal (HPA) axis, elicited the production of plasmatic corticosterone, and decreased ODC expression.	1,2-Dimethylhydrazine	27-30	ornithine decarboxylase, structural 1	Mus musculus	106-109
33259012-7	2020	The short-term exposure to DMH triggered colon inflammation, initiated colon carcinogenesis and increased ODC expression; meanwhile, the exposure to chronic stress activated the hypothalamic-pituitary-adrenal (HPA) axis, elicited the production of plasmatic corticosterone, and decreased ODC expression.	1,2-Dimethylhydrazine	27-30	ornithine decarboxylase, structural 1	Mus musculus	288-291
33289288-5	2020	Results demonstrated that HD inhibited DMH mediated oxidative damage by diminishing the level of peroxidation of lipids and increasing the activity of superoxide dismutase, catalase, reduced glutathione, glutathione peroxidase, glutathione-s-transferase, and glutathione reductase.	1,2-Dimethylhydrazine	39-42	glutathione-disulfide reductase	Rattus norvegicus	259-280
31797281-4	2020	The preventive administration of L. casei to DMH-treated mice increased IL-17A synthesis and Treg percentages, further indicating a tumor-protecting role.	1,2-Dimethylhydrazine	45-48	interleukin 17A	Mus musculus	72-78
32681548-12	2020	In addition, DMH administration increased inflammatory cytokines in the serum cortical and tumor tissues, as well as decreased the expression levels of brain-derived neurotrophic factor, tyrosine kinase beta receptor and beta-catenin in the cortex.	1,2-Dimethylhydrazine	13-16	brain-derived neurotrophic factor	Rattus norvegicus	152-185
32681548-12	2020	In addition, DMH administration increased inflammatory cytokines in the serum cortical and tumor tissues, as well as decreased the expression levels of brain-derived neurotrophic factor, tyrosine kinase beta receptor and beta-catenin in the cortex.	1,2-Dimethylhydrazine	13-16	catenin beta 1	Rattus norvegicus	221-233
32387197-3	2020	In the short-term study, DMH led to increased leukocyte (comet assay) and colon (H2AX) genotoxicity, enhanced proliferation (Ki-67) and apoptosis (caspase-3) indexes in both liver and colon.	1,2-Dimethylhydrazine	25-28	caspase 3	Rattus norvegicus	147-156
32387197-4	2020	Furthermore, the expression of mRNA (Cat, Gsta1, Gsta2, Gpx1, Gstm1, Sod1, Sod2 and Sod3) and the activity of antioxidant agents were diminished in the colon and liver of DMH-induced rats, eliciting an environment of oxidative stress featuring elevated lipid hydroperoxide levels.	1,2-Dimethylhydrazine	171-174	glutathione S-transferase alpha 1	Rattus norvegicus	42-47
32387197-4	2020	Furthermore, the expression of mRNA (Cat, Gsta1, Gsta2, Gpx1, Gstm1, Sod1, Sod2 and Sod3) and the activity of antioxidant agents were diminished in the colon and liver of DMH-induced rats, eliciting an environment of oxidative stress featuring elevated lipid hydroperoxide levels.	1,2-Dimethylhydrazine	171-174	glutathione S-transferase alpha 2	Rattus norvegicus	49-54
32387197-4	2020	Furthermore, the expression of mRNA (Cat, Gsta1, Gsta2, Gpx1, Gstm1, Sod1, Sod2 and Sod3) and the activity of antioxidant agents were diminished in the colon and liver of DMH-induced rats, eliciting an environment of oxidative stress featuring elevated lipid hydroperoxide levels.	1,2-Dimethylhydrazine	171-174	glutathione peroxidase 1	Rattus norvegicus	56-60
32387197-4	2020	Furthermore, the expression of mRNA (Cat, Gsta1, Gsta2, Gpx1, Gstm1, Sod1, Sod2 and Sod3) and the activity of antioxidant agents were diminished in the colon and liver of DMH-induced rats, eliciting an environment of oxidative stress featuring elevated lipid hydroperoxide levels.	1,2-Dimethylhydrazine	171-174	glutathione S-transferase mu 1	Rattus norvegicus	62-67
32387197-4	2020	Furthermore, the expression of mRNA (Cat, Gsta1, Gsta2, Gpx1, Gstm1, Sod1, Sod2 and Sod3) and the activity of antioxidant agents were diminished in the colon and liver of DMH-induced rats, eliciting an environment of oxidative stress featuring elevated lipid hydroperoxide levels.	1,2-Dimethylhydrazine	171-174	superoxide dismutase 1	Rattus norvegicus	69-73
32387197-4	2020	Furthermore, the expression of mRNA (Cat, Gsta1, Gsta2, Gpx1, Gstm1, Sod1, Sod2 and Sod3) and the activity of antioxidant agents were diminished in the colon and liver of DMH-induced rats, eliciting an environment of oxidative stress featuring elevated lipid hydroperoxide levels.	1,2-Dimethylhydrazine	171-174	superoxide dismutase 2	Rattus norvegicus	75-79
32387197-4	2020	Furthermore, the expression of mRNA (Cat, Gsta1, Gsta2, Gpx1, Gstm1, Sod1, Sod2 and Sod3) and the activity of antioxidant agents were diminished in the colon and liver of DMH-induced rats, eliciting an environment of oxidative stress featuring elevated lipid hydroperoxide levels.	1,2-Dimethylhydrazine	171-174	superoxide dismutase 3	Rattus norvegicus	84-88
31925992-6	2020	It also ameliorates the expression of proliferation, inflammation, apoptosis, goblet cell disintegration, and mucin depletion in the colon that was elevated upon administration of DMH.	1,2-Dimethylhydrazine	180-183	solute carrier family 13 member 2	Rattus norvegicus	110-115
32220623-0	2020	Quercetin attenuated oxidative DNA damage through NRF2 signaling pathway in rats with DMH induced colon carcinogenesis.	1,2-Dimethylhydrazine	86-89	NFE2 like bZIP transcription factor 2	Rattus norvegicus	50-54
32220623-8	2020	In addition, quercetin also modulated NRF2/Keap1 signaling and its targets, detoxifying enzymes in DMH + Quercetin groups.	1,2-Dimethylhydrazine	99-102	NFE2 like bZIP transcription factor 2	Rattus norvegicus	38-42
32220623-8	2020	In addition, quercetin also modulated NRF2/Keap1 signaling and its targets, detoxifying enzymes in DMH + Quercetin groups.	1,2-Dimethylhydrazine	99-102	Kelch-like ECH-associated protein 1	Rattus norvegicus	43-48
32220623-9	2020	Our finding demonstrated that quercetin supplementation effectively reversed DMH-mediated oxidative stress and DNA damage through targeting NRF2/Keap1 signaling pathway.	1,2-Dimethylhydrazine	77-80	NFE2 like bZIP transcription factor 2	Rattus norvegicus	140-144
32220623-9	2020	Our finding demonstrated that quercetin supplementation effectively reversed DMH-mediated oxidative stress and DNA damage through targeting NRF2/Keap1 signaling pathway.	1,2-Dimethylhydrazine	77-80	Kelch-like ECH-associated protein 1	Rattus norvegicus	145-150
31925992-8	2020	The results of this study clearly indicate supplementation of GA is beneficial in ameliorating DMH-induced oxidative stress, inflammation, proliferation, apoptosis, mucin depletion, and goblet cell disintegration in colon of Wistar rats.	1,2-Dimethylhydrazine	95-98	solute carrier family 13 member 2	Rattus norvegicus	165-170
32145354-7	2020	Cr(VI) also increased DMH-induced proliferating cell nuclear antigen (PCNA) levels.	1,2-Dimethylhydrazine	22-25	proliferating cell nuclear antigen	Mus musculus	34-68
32145354-7	2020	Cr(VI) also increased DMH-induced proliferating cell nuclear antigen (PCNA) levels.	1,2-Dimethylhydrazine	22-25	proliferating cell nuclear antigen	Mus musculus	70-74
32145354-8	2020	Investigation of the underlying mechanisms found that Cr(VI) significantly decreased DMH-induced SOD, GSH and CAT levels, while, the MDA level increased.	1,2-Dimethylhydrazine	85-88	catalase	Mus musculus	110-113
31981594-3	2020	The in vivo anticancer efficacy of HD-5 against 1,2-dimethylhydrazine (DMH) induced colon cancer was elucidated in terms of tumor biostatistics, number of aberrant crypt foci (ACF), in situ apoptosis assay,changes in morphological as well as histological architecture of colon(s).	1,2-Dimethylhydrazine	48-69	defensin alpha 5	Homo sapiens	35-39
31981594-3	2020	The in vivo anticancer efficacy of HD-5 against 1,2-dimethylhydrazine (DMH) induced colon cancer was elucidated in terms of tumor biostatistics, number of aberrant crypt foci (ACF), in situ apoptosis assay,changes in morphological as well as histological architecture of colon(s).	1,2-Dimethylhydrazine	71-74	defensin alpha 5	Homo sapiens	35-39
30176242-4	2020	In the current study, we compared Fos activation in orexin neurons located in medial hypothalamus (DMH and PFA) to those in LH during a Go/No-Go task for a highly palatable food reward, a task that would likely activate regions for arousal/attention as well as reward.	1,2-Dimethylhydrazine	99-102	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	34-37
30176242-4	2020	In the current study, we compared Fos activation in orexin neurons located in medial hypothalamus (DMH and PFA) to those in LH during a Go/No-Go task for a highly palatable food reward, a task that would likely activate regions for arousal/attention as well as reward.	1,2-Dimethylhydrazine	99-102	hypocretin neuropeptide precursor	Homo sapiens	52-58
31614098-8	2020	Protein levels of COX-2 and PCNA and serum levels of IL-6 and TNF-alpha were significantly elevated in the rats receiving DMH and downregulated after performing the exercise program (P < 0.05).	1,2-Dimethylhydrazine	122-125	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	18-23
31614098-8	2020	Protein levels of COX-2 and PCNA and serum levels of IL-6 and TNF-alpha were significantly elevated in the rats receiving DMH and downregulated after performing the exercise program (P < 0.05).	1,2-Dimethylhydrazine	122-125	proliferating cell nuclear antigen	Rattus norvegicus	28-32
31614098-8	2020	Protein levels of COX-2 and PCNA and serum levels of IL-6 and TNF-alpha were significantly elevated in the rats receiving DMH and downregulated after performing the exercise program (P < 0.05).	1,2-Dimethylhydrazine	122-125	interleukin 6	Rattus norvegicus	53-57
31614098-8	2020	Protein levels of COX-2 and PCNA and serum levels of IL-6 and TNF-alpha were significantly elevated in the rats receiving DMH and downregulated after performing the exercise program (P < 0.05).	1,2-Dimethylhydrazine	122-125	tumor necrosis factor	Rattus norvegicus	62-71
31653646-9	2020	Tumor preventive activity of CBL0137 in vivo was tested in a murine model of colorectal carcinogenesis induced by 1,2-dimethylhydrazine (DMH), which is known to involve WNT pathway dysregulation.	1,2-Dimethylhydrazine	114-135	Casitas B-lineage lymphoma	Mus musculus	29-32
31653646-9	2020	Tumor preventive activity of CBL0137 in vivo was tested in a murine model of colorectal carcinogenesis induced by 1,2-dimethylhydrazine (DMH), which is known to involve WNT pathway dysregulation.	1,2-Dimethylhydrazine	137-140	Casitas B-lineage lymphoma	Mus musculus	29-32
29722557-7	2019	Administration of DMH alone did not induce hepatic GST-P positive foci, while co-treatment with DMH enhanced hepatic GST-P positive foci formation.	1,2-Dimethylhydrazine	96-99	glutathione S-transferase pi 1	Rattus norvegicus	117-122
32118032-11	2020	The percentages of double labeled neurons in PFA and DMH orexin fields are significantly higher than those neurons in the LH of HbSS-BERK mice (* p < 0.05).	1,2-Dimethylhydrazine	53-56	hypocretin	Mus musculus	57-63
32759551-4	2020	1,2-dimethylhydrazine (DMH) treatment markedly increased the formation of aberrant crypt foci (ACF) and the levels of TNF-alpha and lipid oxidation in mice colons.	1,2-Dimethylhydrazine	0-21	tumor necrosis factor	Mus musculus	118-127
32759551-4	2020	1,2-dimethylhydrazine (DMH) treatment markedly increased the formation of aberrant crypt foci (ACF) and the levels of TNF-alpha and lipid oxidation in mice colons.	1,2-Dimethylhydrazine	23-26	tumor necrosis factor	Mus musculus	118-127
31282756-4	2020	SIRT2 and SIRT3 expressions in DMH group were decreased in liver, colon, and kidney tissues and the decrease further stimulated by kumiss reinforcement.	1,2-Dimethylhydrazine	31-34	sirtuin 2	Mus musculus	0-5
31282756-4	2020	SIRT2 and SIRT3 expressions in DMH group were decreased in liver, colon, and kidney tissues and the decrease further stimulated by kumiss reinforcement.	1,2-Dimethylhydrazine	31-34	sirtuin 3	Mus musculus	10-15
31717536-7	2019	DMH/DSS treatment induced preneoplastic aberrant crypt foci (ACF), elevated serum levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta, as well as decreased pro-apoptotic Bax expression.	1,2-Dimethylhydrazine	0-3	tumor necrosis factor	Rattus norvegicus	92-125
31717536-7	2019	DMH/DSS treatment induced preneoplastic aberrant crypt foci (ACF), elevated serum levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta, as well as decreased pro-apoptotic Bax expression.	1,2-Dimethylhydrazine	0-3	interleukin 6	Rattus norvegicus	127-145
31717536-7	2019	DMH/DSS treatment induced preneoplastic aberrant crypt foci (ACF), elevated serum levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta, as well as decreased pro-apoptotic Bax expression.	1,2-Dimethylhydrazine	0-3	interleukin 1 beta	Rattus norvegicus	150-158
31717536-7	2019	DMH/DSS treatment induced preneoplastic aberrant crypt foci (ACF), elevated serum levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta, as well as decreased pro-apoptotic Bax expression.	1,2-Dimethylhydrazine	0-3	BCL2 associated X, apoptosis regulator	Rattus norvegicus	195-198
29722557-9	2019	The treatment with DMH alone induced CYP2E1 and P450 reductase, demonstrating that DMH enhanced DEN metabolism in DEN- and DMH-treated rats.	1,2-Dimethylhydrazine	19-22	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	37-43
29722557-9	2019	The treatment with DMH alone induced CYP2E1 and P450 reductase, demonstrating that DMH enhanced DEN metabolism in DEN- and DMH-treated rats.	1,2-Dimethylhydrazine	83-86	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	37-43
29722557-9	2019	The treatment with DMH alone induced CYP2E1 and P450 reductase, demonstrating that DMH enhanced DEN metabolism in DEN- and DMH-treated rats.	1,2-Dimethylhydrazine	83-86	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	37-43
30407216-3	2019	1,2-dimethylhydrazine-administered rats supplemented with p-CA showed downregulation of the expression of colonic proteins, namely, cyclin B1, cdc2, and mdm2, which regulate cell cycle, and immediate early response genes, namely, c-fos, c-jun and c-myc, which regulate cell proliferation.	1,2-Dimethylhydrazine	0-21	cyclin B1	Rattus norvegicus	132-141
30407216-3	2019	1,2-dimethylhydrazine-administered rats supplemented with p-CA showed downregulation of the expression of colonic proteins, namely, cyclin B1, cdc2, and mdm2, which regulate cell cycle, and immediate early response genes, namely, c-fos, c-jun and c-myc, which regulate cell proliferation.	1,2-Dimethylhydrazine	0-21	cyclin-dependent kinase 1	Rattus norvegicus	143-147
30407216-3	2019	1,2-dimethylhydrazine-administered rats supplemented with p-CA showed downregulation of the expression of colonic proteins, namely, cyclin B1, cdc2, and mdm2, which regulate cell cycle, and immediate early response genes, namely, c-fos, c-jun and c-myc, which regulate cell proliferation.	1,2-Dimethylhydrazine	0-21	MDM2 proto-oncogene	Rattus norvegicus	153-157
30407216-3	2019	1,2-dimethylhydrazine-administered rats supplemented with p-CA showed downregulation of the expression of colonic proteins, namely, cyclin B1, cdc2, and mdm2, which regulate cell cycle, and immediate early response genes, namely, c-fos, c-jun and c-myc, which regulate cell proliferation.	1,2-Dimethylhydrazine	0-21	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	230-235
30407216-3	2019	1,2-dimethylhydrazine-administered rats supplemented with p-CA showed downregulation of the expression of colonic proteins, namely, cyclin B1, cdc2, and mdm2, which regulate cell cycle, and immediate early response genes, namely, c-fos, c-jun and c-myc, which regulate cell proliferation.	1,2-Dimethylhydrazine	0-21	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	247-252
31235650-10	2019	Further, the readily releasable pool of GABA vesicles and the release probability of GABA is increased at DMH-to-POMC synapses following an overnight fast.	1,2-Dimethylhydrazine	106-109	pro-opiomelanocortin-alpha	Mus musculus	113-117
31585636-8	2019	Gene expression analysis of 91 target-genes revealed that only three genes (Figf, Pik3r5 and Tgfbr2) were down-regulated in the tumors from hemin-fed rats compared to those from 1,2-DMH control group.	1,2-Dimethylhydrazine	178-185	transforming growth factor, beta receptor 2	Rattus norvegicus	93-99
32274393-5	2019	Results: The DMH plus selenium-treated group exhibited significantly lower expression of cloned caudal-type homebox gene -2 (CDX-2) and vascular endothelial growth factor (VEGF) but higher caspase-3 expression level at p < 0.001 compared to the DMH-treated group.	1,2-Dimethylhydrazine	13-16	caudal type homeobox 2	Mus musculus	96-123
32274393-5	2019	Results: The DMH plus selenium-treated group exhibited significantly lower expression of cloned caudal-type homebox gene -2 (CDX-2) and vascular endothelial growth factor (VEGF) but higher caspase-3 expression level at p < 0.001 compared to the DMH-treated group.	1,2-Dimethylhydrazine	13-16	caudal type homeobox 2	Mus musculus	125-130
32274393-5	2019	Results: The DMH plus selenium-treated group exhibited significantly lower expression of cloned caudal-type homebox gene -2 (CDX-2) and vascular endothelial growth factor (VEGF) but higher caspase-3 expression level at p < 0.001 compared to the DMH-treated group.	1,2-Dimethylhydrazine	13-16	vascular endothelial growth factor A	Mus musculus	136-170
32274393-5	2019	Results: The DMH plus selenium-treated group exhibited significantly lower expression of cloned caudal-type homebox gene -2 (CDX-2) and vascular endothelial growth factor (VEGF) but higher caspase-3 expression level at p < 0.001 compared to the DMH-treated group.	1,2-Dimethylhydrazine	13-16	vascular endothelial growth factor A	Mus musculus	172-176
32274393-5	2019	Results: The DMH plus selenium-treated group exhibited significantly lower expression of cloned caudal-type homebox gene -2 (CDX-2) and vascular endothelial growth factor (VEGF) but higher caspase-3 expression level at p < 0.001 compared to the DMH-treated group.	1,2-Dimethylhydrazine	13-16	caspase 3	Mus musculus	189-198
31235650-11	2019	Collectively these data provide evidence that DMH-to-POMC GABA circuitry conveys inhibitory neuromodulation onto POMC cells that is sensitive to the animal"s energy state.SIGNIFICANCE STATEMENT Activation of proopiomelanocortin (POMC) cells signals satiety, whereas GABAergic cells in the dorsomedial hypothalamus (DMH) can increase food consumption.	1,2-Dimethylhydrazine	46-49	pro-opiomelanocortin-alpha	Mus musculus	53-57
31235650-11	2019	Collectively these data provide evidence that DMH-to-POMC GABA circuitry conveys inhibitory neuromodulation onto POMC cells that is sensitive to the animal"s energy state.SIGNIFICANCE STATEMENT Activation of proopiomelanocortin (POMC) cells signals satiety, whereas GABAergic cells in the dorsomedial hypothalamus (DMH) can increase food consumption.	1,2-Dimethylhydrazine	46-49	pro-opiomelanocortin-alpha	Mus musculus	113-117
31235650-11	2019	Collectively these data provide evidence that DMH-to-POMC GABA circuitry conveys inhibitory neuromodulation onto POMC cells that is sensitive to the animal"s energy state.SIGNIFICANCE STATEMENT Activation of proopiomelanocortin (POMC) cells signals satiety, whereas GABAergic cells in the dorsomedial hypothalamus (DMH) can increase food consumption.	1,2-Dimethylhydrazine	46-49	pro-opiomelanocortin-alpha	Mus musculus	208-227
31235650-11	2019	Collectively these data provide evidence that DMH-to-POMC GABA circuitry conveys inhibitory neuromodulation onto POMC cells that is sensitive to the animal"s energy state.SIGNIFICANCE STATEMENT Activation of proopiomelanocortin (POMC) cells signals satiety, whereas GABAergic cells in the dorsomedial hypothalamus (DMH) can increase food consumption.	1,2-Dimethylhydrazine	46-49	pro-opiomelanocortin-alpha	Mus musculus	113-117
31235650-13	2019	Here, through targeted inhibition of DMH GABA release, we show that DMH neurons contribute a significant portion of spontaneously released GABA onto POMC cells and are responsible for increased GABAergic inhibition of POMC cells during fasting, likely mediated through increased release probability of GABA at DMH terminals.	1,2-Dimethylhydrazine	37-40	pro-opiomelanocortin-alpha	Mus musculus	149-153
31235650-13	2019	Here, through targeted inhibition of DMH GABA release, we show that DMH neurons contribute a significant portion of spontaneously released GABA onto POMC cells and are responsible for increased GABAergic inhibition of POMC cells during fasting, likely mediated through increased release probability of GABA at DMH terminals.	1,2-Dimethylhydrazine	37-40	pro-opiomelanocortin-alpha	Mus musculus	218-222
31235650-13	2019	Here, through targeted inhibition of DMH GABA release, we show that DMH neurons contribute a significant portion of spontaneously released GABA onto POMC cells and are responsible for increased GABAergic inhibition of POMC cells during fasting, likely mediated through increased release probability of GABA at DMH terminals.	1,2-Dimethylhydrazine	68-71	pro-opiomelanocortin-alpha	Mus musculus	149-153
31235650-13	2019	Here, through targeted inhibition of DMH GABA release, we show that DMH neurons contribute a significant portion of spontaneously released GABA onto POMC cells and are responsible for increased GABAergic inhibition of POMC cells during fasting, likely mediated through increased release probability of GABA at DMH terminals.	1,2-Dimethylhydrazine	68-71	pro-opiomelanocortin-alpha	Mus musculus	218-222
31235650-13	2019	Here, through targeted inhibition of DMH GABA release, we show that DMH neurons contribute a significant portion of spontaneously released GABA onto POMC cells and are responsible for increased GABAergic inhibition of POMC cells during fasting, likely mediated through increased release probability of GABA at DMH terminals.	1,2-Dimethylhydrazine	68-71	pro-opiomelanocortin-alpha	Mus musculus	149-153
31235650-13	2019	Here, through targeted inhibition of DMH GABA release, we show that DMH neurons contribute a significant portion of spontaneously released GABA onto POMC cells and are responsible for increased GABAergic inhibition of POMC cells during fasting, likely mediated through increased release probability of GABA at DMH terminals.	1,2-Dimethylhydrazine	68-71	pro-opiomelanocortin-alpha	Mus musculus	218-222
31342663-10	2019	The preexisting sensitivity to the anorexigenic effects of leptin, a predictor for obesity, correlates with the sensitivity to the thermoregulatory effects of leptin, which appears to be exerted, at least in part, at the level of the DMH.	1,2-Dimethylhydrazine	234-237	leptin	Rattus norvegicus	59-65
31014927-6	2019	Studies in mice with loss of MC4R in the DMH suggest that defective DMH MC4R/Gsalpha signaling contributes to abnormal energy balance but not to abnormal locomotor activity or cold-induced thermogenesis.	1,2-Dimethylhydrazine	41-44	melanocortin 4 receptor	Mus musculus	29-33
31342663-10	2019	The preexisting sensitivity to the anorexigenic effects of leptin, a predictor for obesity, correlates with the sensitivity to the thermoregulatory effects of leptin, which appears to be exerted, at least in part, at the level of the DMH.	1,2-Dimethylhydrazine	234-237	leptin	Rattus norvegicus	159-165
30902570-7	2019	In contrast, the expression of Trh in the DMH was decreased in OLETF-SED rats relative to LETO-SED rats.	1,2-Dimethylhydrazine	42-45	thyrotropin releasing hormone	Rattus norvegicus	31-34
31014927-6	2019	Studies in mice with loss of MC4R in the DMH suggest that defective DMH MC4R/Gsalpha signaling contributes to abnormal energy balance but not to abnormal locomotor activity or cold-induced thermogenesis.	1,2-Dimethylhydrazine	41-44	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	Mus musculus	77-84
31014927-6	2019	Studies in mice with loss of MC4R in the DMH suggest that defective DMH MC4R/Gsalpha signaling contributes to abnormal energy balance but not to abnormal locomotor activity or cold-induced thermogenesis.	1,2-Dimethylhydrazine	68-71	melanocortin 4 receptor	Mus musculus	29-33
31014927-6	2019	Studies in mice with loss of MC4R in the DMH suggest that defective DMH MC4R/Gsalpha signaling contributes to abnormal energy balance but not to abnormal locomotor activity or cold-induced thermogenesis.	1,2-Dimethylhydrazine	68-71	melanocortin 4 receptor	Mus musculus	72-76
31014927-6	2019	Studies in mice with loss of MC4R in the DMH suggest that defective DMH MC4R/Gsalpha signaling contributes to abnormal energy balance but not to abnormal locomotor activity or cold-induced thermogenesis.	1,2-Dimethylhydrazine	68-71	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	Mus musculus	77-84
31014927-8	2019	CONCLUSIONS: DMH Gsalpha signaling is critical for energy balance, thermogenesis, and leptin signaling.	1,2-Dimethylhydrazine	13-16	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	Mus musculus	17-24
30902570-8	2019	This alteration was reversed in OLETF-RW rats as seen in LETO-SED rats, but food restriction resulted in a significant increase in DMH Trh expression in OLETF-PF rats compared to LETO-SED rats.	1,2-Dimethylhydrazine	131-134	thyrotropin releasing hormone	Rattus norvegicus	135-138
30902570-9	2019	Strikingly, while Trh mRNA expression was decreased in the PVN of intact rats in response to acute food deprivation, food deprivation resulted in increased expression of Trh in the DMH.	1,2-Dimethylhydrazine	181-184	thyrotropin releasing hormone	Rattus norvegicus	170-173
30902570-10	2019	Together, these results demonstrate the differential regulation of Trh expression in the PVN and DMH in OLETF rats and suggest that DMH TRH also contributes to hypothalamic regulation of energy balance.	1,2-Dimethylhydrazine	97-100	thyrotropin releasing hormone	Rattus norvegicus	67-70
30902570-10	2019	Together, these results demonstrate the differential regulation of Trh expression in the PVN and DMH in OLETF rats and suggest that DMH TRH also contributes to hypothalamic regulation of energy balance.	1,2-Dimethylhydrazine	132-135	thyrotropin releasing hormone	Rattus norvegicus	136-139
30718415-4	2019	Here, we report that TrkB-expressing neurons in the dorsomedial hypothalamus (DMH) regulate food intake.	1,2-Dimethylhydrazine	78-81	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	21-25
30694375-7	2019	In addition, this panicolytic-like effect was prevented by pretreatment of the DMH with the CB1 receptor antagonist AM251 (100 pmol).	1,2-Dimethylhydrazine	79-82	cannabinoid receptor 1 (brain)	Mus musculus	92-95
30694375-8	2019	However, pretreatment of the DMH with the TRPV1 receptor antagonist 6-iodo-nordihydrocapsaicin (3 nmol) restored the panicolytic-like effect of the highest dose of anandamide.	1,2-Dimethylhydrazine	29-32	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	42-47
30694375-9	2019	Immunohistochemistry revealed that CB1 receptors were present primarily on axonal fibers, while TRPV1 receptors were found almost exclusively surrounding the perikarya in DMH.	1,2-Dimethylhydrazine	171-174	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	96-101
30720227-9	2019	Our results reveal that DMH treated rats exhibited elevated ROS and MDA levels, increased activity of cytochrome P450 2E1 and serum marker enzyme carcinoembreyonic antigen (CEA), increased no of aberrant crypts of foci (ACF), and elevated expression of inflammatory and proliferative proteins.	1,2-Dimethylhydrazine	24-27	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	102-121
30720227-9	2019	Our results reveal that DMH treated rats exhibited elevated ROS and MDA levels, increased activity of cytochrome P450 2E1 and serum marker enzyme carcinoembreyonic antigen (CEA), increased no of aberrant crypts of foci (ACF), and elevated expression of inflammatory and proliferative proteins.	1,2-Dimethylhydrazine	24-27	carcinoembryonic antigen gene family 4	Rattus norvegicus	146-171
30720227-9	2019	Our results reveal that DMH treated rats exhibited elevated ROS and MDA levels, increased activity of cytochrome P450 2E1 and serum marker enzyme carcinoembreyonic antigen (CEA), increased no of aberrant crypts of foci (ACF), and elevated expression of inflammatory and proliferative proteins.	1,2-Dimethylhydrazine	24-27	carcinoembryonic antigen gene family 4	Rattus norvegicus	173-176
30720227-10	2019	Nrf-2 was downregulated by DMH treatment.	1,2-Dimethylhydrazine	27-30	NFE2 like bZIP transcription factor 2	Rattus norvegicus	0-5
30720227-11	2019	Treatment with zingerone to DMH treated rats, resulted in alterations in the activity of the cytochrome P450 2E1 and CEA.	1,2-Dimethylhydrazine	28-31	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	93-112
30720227-11	2019	Treatment with zingerone to DMH treated rats, resulted in alterations in the activity of the cytochrome P450 2E1 and CEA.	1,2-Dimethylhydrazine	28-31	carcinoembryonic antigen gene family 4	Rattus norvegicus	117-120
30718415-5	2019	We found that the DMH contains both glutamatergic and GABAergic TrkB-expressing neurons, some of which also express the leptin receptor (LepR).	1,2-Dimethylhydrazine	18-21	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	64-68
30718415-5	2019	We found that the DMH contains both glutamatergic and GABAergic TrkB-expressing neurons, some of which also express the leptin receptor (LepR).	1,2-Dimethylhydrazine	18-21	leptin receptor	Mus musculus	120-135
30718415-5	2019	We found that the DMH contains both glutamatergic and GABAergic TrkB-expressing neurons, some of which also express the leptin receptor (LepR).	1,2-Dimethylhydrazine	18-21	leptin receptor	Mus musculus	137-141
30718415-6	2019	As revealed by Fos immunohistochemistry, a significant number of TrkB-expressing DMH (DMHTrkB) neurons were activated upon either overnight fasting or after refeeding.	1,2-Dimethylhydrazine	81-84	FBJ osteosarcoma oncogene	Mus musculus	15-18
30718415-6	2019	As revealed by Fos immunohistochemistry, a significant number of TrkB-expressing DMH (DMHTrkB) neurons were activated upon either overnight fasting or after refeeding.	1,2-Dimethylhydrazine	81-84	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	65-69
30718415-9	2019	Furthermore, selective Ntrk2 deletion in the DMH of adult mice led to hyperphagia, reduced energy expenditure, and obesity.	1,2-Dimethylhydrazine	45-48	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	23-28
29956073-9	2019	CONCLUSIONS: The subcellular localization of beta-catenin and decorin, septin-7, and S100A10 expressions are associated with the development of colorectal cancer in mice after N,N-dimethylhydrazine treatment and in human hereditary polyposis colorectal cancers.	1,2-Dimethylhydrazine	176-197	catenin (cadherin associated protein), beta 1	Mus musculus	45-57
29956073-9	2019	CONCLUSIONS: The subcellular localization of beta-catenin and decorin, septin-7, and S100A10 expressions are associated with the development of colorectal cancer in mice after N,N-dimethylhydrazine treatment and in human hereditary polyposis colorectal cancers.	1,2-Dimethylhydrazine	176-197	decorin	Mus musculus	62-69
29956073-9	2019	CONCLUSIONS: The subcellular localization of beta-catenin and decorin, septin-7, and S100A10 expressions are associated with the development of colorectal cancer in mice after N,N-dimethylhydrazine treatment and in human hereditary polyposis colorectal cancers.	1,2-Dimethylhydrazine	176-197	septin 7	Mus musculus	71-79
29956073-9	2019	CONCLUSIONS: The subcellular localization of beta-catenin and decorin, septin-7, and S100A10 expressions are associated with the development of colorectal cancer in mice after N,N-dimethylhydrazine treatment and in human hereditary polyposis colorectal cancers.	1,2-Dimethylhydrazine	176-197	S100 calcium binding protein A10 (calpactin)	Mus musculus	85-92
31149056-12	2019	Conclusion: These results suggest that DMH NPY knock-down improves hepatic insulin sensitivity in HF diet-fed rats by activating the hepatic PI3K/AKT insulin signalling pathway.	1,2-Dimethylhydrazine	39-42	neuropeptide Y	Rattus norvegicus	43-46
31149056-12	2019	Conclusion: These results suggest that DMH NPY knock-down improves hepatic insulin sensitivity in HF diet-fed rats by activating the hepatic PI3K/AKT insulin signalling pathway.	1,2-Dimethylhydrazine	39-42	AKT serine/threonine kinase 1	Rattus norvegicus	146-149
30140065-9	2018	Greater numbers of c-Fos-positive cells in the rostral ventrolateral medulla (RVLM) and of c-Fos-positive orexin neurons in the dorsomedial hypothalamus (DMH) were detected in sucrose agar-treated SHRs, compared to regular chow-treated SHRs and to sucrose agar-treated WKY rats.	1,2-Dimethylhydrazine	154-157	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	91-96
30255981-10	2018	Glycyrrhizic acid also significantly ameliorated DMH-induced decreased activities of caspase-9 and caspase-3.	1,2-Dimethylhydrazine	49-52	caspase 9	Rattus norvegicus	85-94
30255981-10	2018	Glycyrrhizic acid also significantly ameliorated DMH-induced decreased activities of caspase-9 and caspase-3.	1,2-Dimethylhydrazine	49-52	caspase 3	Rattus norvegicus	99-108
30014223-7	2018	ACF were induced in rats treated with DMH and showed increased expression of the inflammatory cytokines IL-6, IL-8, and TNF-alpha.	1,2-Dimethylhydrazine	38-41	interleukin 6	Rattus norvegicus	104-108
30014223-7	2018	ACF were induced in rats treated with DMH and showed increased expression of the inflammatory cytokines IL-6, IL-8, and TNF-alpha.	1,2-Dimethylhydrazine	38-41	tumor necrosis factor	Rattus norvegicus	120-129
30618603-6	2018	Peripheral Angptl8 administration decreased c-Fos-positive neurons in the DMH.	1,2-Dimethylhydrazine	74-77	angiopoietin like 8	Homo sapiens	11-18
30618603-6	2018	Peripheral Angptl8 administration decreased c-Fos-positive neurons in the DMH.	1,2-Dimethylhydrazine	74-77	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	44-49
30618603-7	2018	Central Angptl8 administration decreased c-Fos-positive neurons in the DMH and PVN but increased these neurons in the ARC.	1,2-Dimethylhydrazine	71-74	angiopoietin like 8	Homo sapiens	8-15
30618603-8	2018	Angptl8 inhibited appetite via neuropeptide Y (NPY) neurons in the DMH.	1,2-Dimethylhydrazine	67-70	angiopoietin like 8	Homo sapiens	0-7
30618603-8	2018	Angptl8 inhibited appetite via neuropeptide Y (NPY) neurons in the DMH.	1,2-Dimethylhydrazine	67-70	neuropeptide Y	Homo sapiens	31-45
30140065-9	2018	Greater numbers of c-Fos-positive cells in the rostral ventrolateral medulla (RVLM) and of c-Fos-positive orexin neurons in the dorsomedial hypothalamus (DMH) were detected in sucrose agar-treated SHRs, compared to regular chow-treated SHRs and to sucrose agar-treated WKY rats.	1,2-Dimethylhydrazine	154-157	hypocretin neuropeptide precursor	Rattus norvegicus	106-112
30140065-11	2018	We concluded that in SHRs, orexin neurons in the DMH might be overactive during eating palatable food and may further elicit exaggerated cardiovascular responses via an OX2R-RVLM pathway.	1,2-Dimethylhydrazine	49-52	hypocretin neuropeptide precursor	Rattus norvegicus	27-33
30140065-11	2018	We concluded that in SHRs, orexin neurons in the DMH might be overactive during eating palatable food and may further elicit exaggerated cardiovascular responses via an OX2R-RVLM pathway.	1,2-Dimethylhydrazine	49-52	hypocretin receptor 2	Rattus norvegicus	169-173
29896090-3	2018	Here, we identified the action of neuronal activation in the dorsomedial hypothalamus (DMH) in modulating physical activity, food intake and body weight using leptin receptor mutant obese Zucker (Lepr(fa), ZF) and Koletsky (Lepr(fak), SHROB) rats.	1,2-Dimethylhydrazine	87-90	leptin receptor	Rattus norvegicus	196-200
29879413-5	2018	Administration of the procarcinogen 1,2- dimethylhydrazine (DMH) causes Grp78 upregulation and tumor adaptation via UPR activation.	1,2-Dimethylhydrazine	36-58	heat shock protein family A (Hsp70) member 5	Homo sapiens	72-77
29562216-8	2018	A significant increase was detected in MMP-2, MMP-9 levels and MMP-2/TIMP-2 ratio in DMH group as compared with controls and treatment groups.	1,2-Dimethylhydrazine	85-88	matrix metallopeptidase 2	Rattus norvegicus	39-44
29562216-8	2018	A significant increase was detected in MMP-2, MMP-9 levels and MMP-2/TIMP-2 ratio in DMH group as compared with controls and treatment groups.	1,2-Dimethylhydrazine	85-88	matrix metallopeptidase 2	Rattus norvegicus	63-68
29562216-8	2018	A significant increase was detected in MMP-2, MMP-9 levels and MMP-2/TIMP-2 ratio in DMH group as compared with controls and treatment groups.	1,2-Dimethylhydrazine	85-88	TIMP metallopeptidase inhibitor 2	Rattus norvegicus	69-75
29562216-9	2018	In immunohistochemical evaluations, there was an increase in intensity and extent of staining of MMP-2 and MMP-9 in DMH group as compared to controls and treatment groups.	1,2-Dimethylhydrazine	116-119	matrix metallopeptidase 2	Rattus norvegicus	97-102
29562216-9	2018	In immunohistochemical evaluations, there was an increase in intensity and extent of staining of MMP-2 and MMP-9 in DMH group as compared to controls and treatment groups.	1,2-Dimethylhydrazine	116-119	matrix metallopeptidase 9	Rattus norvegicus	107-112
29562216-11	2018	Overall, it was concluded that NSAIDs, particularly cyclooxygenase-2 (COX-2) inhibitors, might have a protective effect on CRC development and slow down progression of tumor in a DMH-induced experimental cancer model.	1,2-Dimethylhydrazine	179-182	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	52-68
29562216-11	2018	Overall, it was concluded that NSAIDs, particularly cyclooxygenase-2 (COX-2) inhibitors, might have a protective effect on CRC development and slow down progression of tumor in a DMH-induced experimental cancer model.	1,2-Dimethylhydrazine	179-182	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	70-75
29896090-3	2018	Here, we identified the action of neuronal activation in the dorsomedial hypothalamus (DMH) in modulating physical activity, food intake and body weight using leptin receptor mutant obese Zucker (Lepr(fa), ZF) and Koletsky (Lepr(fak), SHROB) rats.	1,2-Dimethylhydrazine	87-90	leptin receptor	Rattus norvegicus	224-228
29896090-3	2018	Here, we identified the action of neuronal activation in the dorsomedial hypothalamus (DMH) in modulating physical activity, food intake and body weight using leptin receptor mutant obese Zucker (Lepr(fa), ZF) and Koletsky (Lepr(fak), SHROB) rats.	1,2-Dimethylhydrazine	87-90	protein tyrosine kinase 2	Rattus norvegicus	229-232
29896090-8	2018	Strikingly, c-Fos immunohistochemistry revealed that while voluntary running activity elevated the number of c-Fos positive cells in the DMH (particularly in the ventral and caudal subregions) of intact rats, such activation was not observed in ZF rats.	1,2-Dimethylhydrazine	137-140	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	12-17
29896090-8	2018	Strikingly, c-Fos immunohistochemistry revealed that while voluntary running activity elevated the number of c-Fos positive cells in the DMH (particularly in the ventral and caudal subregions) of intact rats, such activation was not observed in ZF rats.	1,2-Dimethylhydrazine	137-140	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	109-114
29650350-4	2018	RESULTS: GLP-1 administered into the DMH increased BAT thermogenesis and hepatic triglyceride (TG) mobilization.	1,2-Dimethylhydrazine	37-40	glucagon	Rattus norvegicus	9-14
29650350-5	2018	On the other hand, Glp1r knockdown (KD) in the DMH increased body weight gain and adiposity, with a concomitant reduction in energy expenditure (EE), BAT temperature, and uncoupling protein 1 (UCP1) expression.	1,2-Dimethylhydrazine	47-50	glucagon-like peptide 1 receptor	Rattus norvegicus	19-24
29650350-6	2018	Moreover, DMH Glp1r KD induced hepatic steatosis, increased plasma TG, and elevated liver specific de-novo lipogenesis, effects that collectively contributed to insulin resistance.	1,2-Dimethylhydrazine	10-13	glucagon-like peptide 1 receptor	Rattus norvegicus	14-19
29650350-7	2018	Interestingly, DMH Glp1r KD increased neuropeptide Y (NPY) mRNA expression in the DMH.	1,2-Dimethylhydrazine	15-18	glucagon-like peptide 1 receptor	Rattus norvegicus	19-24
29650350-7	2018	Interestingly, DMH Glp1r KD increased neuropeptide Y (NPY) mRNA expression in the DMH.	1,2-Dimethylhydrazine	15-18	neuropeptide Y	Rattus norvegicus	38-52
29650350-7	2018	Interestingly, DMH Glp1r KD increased neuropeptide Y (NPY) mRNA expression in the DMH.	1,2-Dimethylhydrazine	15-18	neuropeptide Y	Rattus norvegicus	54-57
29650350-8	2018	GLP-1R mRNA in the DMH, however, was found in GABAergic not NPY neurons, consistent with a GLP-1R-dependent inhibition of NPY neurons that is mediated by local GABAergic neurons.	1,2-Dimethylhydrazine	19-22	glucagon-like peptide 1 receptor	Rattus norvegicus	0-6
29345053-9	2018	Administration of Naringenin ameliorated the development of DMH-induced lipid peroxidation, ROS formation, precancerous lesions (ACF and MDF) and it also reduced the infiltration of mast cells, suppressed the immunostaining of NF-kappaB-p65, COX-2, i-NOS PCNA and Ki 67 Naringenin treatment significantly attenuated the level of TNF-alpha and it also prevented the depletion of the mucous layer.	1,2-Dimethylhydrazine	60-63	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	242-247
29650350-9	2018	Finally, DMH Glp1r KD attenuated the anorexigenic effects of the GLP-1R agonist exendin-4, highlighting an important role of DMH GLP-1R signaling in GLP-1-based therapies.	1,2-Dimethylhydrazine	9-12	glucagon-like peptide 1 receptor	Rattus norvegicus	13-18
29650350-9	2018	Finally, DMH Glp1r KD attenuated the anorexigenic effects of the GLP-1R agonist exendin-4, highlighting an important role of DMH GLP-1R signaling in GLP-1-based therapies.	1,2-Dimethylhydrazine	9-12	glucagon-like peptide 1 receptor	Rattus norvegicus	65-71
29650350-9	2018	Finally, DMH Glp1r KD attenuated the anorexigenic effects of the GLP-1R agonist exendin-4, highlighting an important role of DMH GLP-1R signaling in GLP-1-based therapies.	1,2-Dimethylhydrazine	9-12	glucagon	Rattus norvegicus	65-70
29650350-10	2018	CONCLUSIONS: Collectively, our data show that DMH GLP-1R signaling plays a key role for BAT thermogenesis and adiposity.	1,2-Dimethylhydrazine	46-49	glucagon-like peptide 1 receptor	Rattus norvegicus	50-56
29453046-6	2018	Morin supplementation to DMH administered rats down regulated NF-kappaB pathway and its downstream inflammatory mediators like tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), cyclooxygenase 2 (COX-2) and prostaglandin (PGE-2).	1,2-Dimethylhydrazine	25-28	tumor necrosis factor	Rattus norvegicus	127-154
29453046-7	2018	Morin supplementation to DMH administered rats alters BAX/BCL2 ratio favoring apoptosis in carcinogen treated rats.	1,2-Dimethylhydrazine	25-28	BCL2 associated X, apoptosis regulator	Rattus norvegicus	54-57
29453046-7	2018	Morin supplementation to DMH administered rats alters BAX/BCL2 ratio favoring apoptosis in carcinogen treated rats.	1,2-Dimethylhydrazine	25-28	BCL2, apoptosis regulator	Rattus norvegicus	58-62
29427224-8	2018	RESULTS: DMH treatment decreased the activity of GSH, GPx, GST, SOD and catalase.	1,2-Dimethylhydrazine	9-12	hematopoietic prostaglandin D synthase	Rattus norvegicus	59-62
29427224-8	2018	RESULTS: DMH treatment decreased the activity of GSH, GPx, GST, SOD and catalase.	1,2-Dimethylhydrazine	9-12	catalase	Rattus norvegicus	72-80
29427224-10	2018	Further, DMH treatment revealed alterations in the protein expressions of various genes involved in the p53-mediated apoptotic pathway such as p53, p21, Bcl-2, Bax, caspase-9 and caspase-3, which, however, were shifted towards normal control levels upon simultaneous supplementation with probiotics.	1,2-Dimethylhydrazine	9-12	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	104-107
29427224-10	2018	Further, DMH treatment revealed alterations in the protein expressions of various genes involved in the p53-mediated apoptotic pathway such as p53, p21, Bcl-2, Bax, caspase-9 and caspase-3, which, however, were shifted towards normal control levels upon simultaneous supplementation with probiotics.	1,2-Dimethylhydrazine	9-12	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	143-146
29427224-10	2018	Further, DMH treatment revealed alterations in the protein expressions of various genes involved in the p53-mediated apoptotic pathway such as p53, p21, Bcl-2, Bax, caspase-9 and caspase-3, which, however, were shifted towards normal control levels upon simultaneous supplementation with probiotics.	1,2-Dimethylhydrazine	9-12	KRAS proto-oncogene, GTPase	Rattus norvegicus	148-151
29427224-10	2018	Further, DMH treatment revealed alterations in the protein expressions of various genes involved in the p53-mediated apoptotic pathway such as p53, p21, Bcl-2, Bax, caspase-9 and caspase-3, which, however, were shifted towards normal control levels upon simultaneous supplementation with probiotics.	1,2-Dimethylhydrazine	9-12	BCL2, apoptosis regulator	Rattus norvegicus	153-158
29427224-10	2018	Further, DMH treatment revealed alterations in the protein expressions of various genes involved in the p53-mediated apoptotic pathway such as p53, p21, Bcl-2, Bax, caspase-9 and caspase-3, which, however, were shifted towards normal control levels upon simultaneous supplementation with probiotics.	1,2-Dimethylhydrazine	9-12	BCL2 associated X, apoptosis regulator	Rattus norvegicus	160-163
29427224-10	2018	Further, DMH treatment revealed alterations in the protein expressions of various genes involved in the p53-mediated apoptotic pathway such as p53, p21, Bcl-2, Bax, caspase-9 and caspase-3, which, however, were shifted towards normal control levels upon simultaneous supplementation with probiotics.	1,2-Dimethylhydrazine	9-12	caspase 9	Rattus norvegicus	165-174
29427224-10	2018	Further, DMH treatment revealed alterations in the protein expressions of various genes involved in the p53-mediated apoptotic pathway such as p53, p21, Bcl-2, Bax, caspase-9 and caspase-3, which, however, were shifted towards normal control levels upon simultaneous supplementation with probiotics.	1,2-Dimethylhydrazine	9-12	caspase 3	Rattus norvegicus	179-188
29345053-9	2018	Administration of Naringenin ameliorated the development of DMH-induced lipid peroxidation, ROS formation, precancerous lesions (ACF and MDF) and it also reduced the infiltration of mast cells, suppressed the immunostaining of NF-kappaB-p65, COX-2, i-NOS PCNA and Ki 67 Naringenin treatment significantly attenuated the level of TNF-alpha and it also prevented the depletion of the mucous layer.	1,2-Dimethylhydrazine	60-63	proliferating cell nuclear antigen	Rattus norvegicus	255-259
29345053-9	2018	Administration of Naringenin ameliorated the development of DMH-induced lipid peroxidation, ROS formation, precancerous lesions (ACF and MDF) and it also reduced the infiltration of mast cells, suppressed the immunostaining of NF-kappaB-p65, COX-2, i-NOS PCNA and Ki 67 Naringenin treatment significantly attenuated the level of TNF-alpha and it also prevented the depletion of the mucous layer.	1,2-Dimethylhydrazine	60-63	tumor necrosis factor	Rattus norvegicus	329-338
29104046-4	2018	An intra-DMH injection of orexin A (30pmol) produced elevation of arterial pressure and heart rate.	1,2-Dimethylhydrazine	9-12	hypocretin neuropeptide precursor	Rattus norvegicus	26-34
29074413-0	2018	Galantamine attenuates N,N-dimethyl hydrazine induced neoplastic colon damage by inhibiting acetylcholinesterase and bimodal regulation of nicotinic cholinergic neurotransmission.	1,2-Dimethylhydrazine	23-45	acetylcholinesterase	Rattus norvegicus	92-112
29439258-12	2018	CONCLUSION: Our findings demonstrated that BMCs have tumor suppressive effects in DMH-induced colon cancer as evidenced by down-regulation of survivin, beta-catenin, and MDR-1 genes and enhancing the antioxidant activity.	1,2-Dimethylhydrazine	82-85	catenin beta 1	Rattus norvegicus	152-164
29439258-12	2018	CONCLUSION: Our findings demonstrated that BMCs have tumor suppressive effects in DMH-induced colon cancer as evidenced by down-regulation of survivin, beta-catenin, and MDR-1 genes and enhancing the antioxidant activity.	1,2-Dimethylhydrazine	82-85	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	170-175
29104046-5	2018	Orexin A-sensitive sites were located within or immediately adjacent to the DMH and larger responses were induced at the compact part of the dorsomedial hypothalamic nucleus.	1,2-Dimethylhydrazine	76-79	hypocretin neuropeptide precursor	Rattus norvegicus	0-8
29104046-6	2018	Orexin A-induced responses were attenuated by intra-DMH pretreatment with an orexin receptor 1 (OX1R) antagonist, SB-334867 (15nmol) (17.7 +- 2.8 vs. 5.2 +- 1.0mmHg; 54.6 +- 10.0 vs. 22.8 +- 7.4 beats/min).	1,2-Dimethylhydrazine	52-55	hypocretin neuropeptide precursor	Rattus norvegicus	0-8
29104046-6	2018	Orexin A-induced responses were attenuated by intra-DMH pretreatment with an orexin receptor 1 (OX1R) antagonist, SB-334867 (15nmol) (17.7 +- 2.8 vs. 5.2 +- 1.0mmHg; 54.6 +- 10.0 vs. 22.8 +- 7.4 beats/min).	1,2-Dimethylhydrazine	52-55	hypocretin receptor 1	Rattus norvegicus	96-100
29104046-7	2018	Intra-DMH applied [Ala11,D-Leu15]-orexin B (300 pmol), an orexin receptor 2 (OX2R) agonist, elicited cardiovascular responses mimicking the responses of orexin A, except for a smaller pressor response (7.4 +- 1.7 vs. 16.4 +- 1.8mmHg).	1,2-Dimethylhydrazine	6-9	hypocretin receptor 2	Rattus norvegicus	77-81
29104046-7	2018	Intra-DMH applied [Ala11,D-Leu15]-orexin B (300 pmol), an orexin receptor 2 (OX2R) agonist, elicited cardiovascular responses mimicking the responses of orexin A, except for a smaller pressor response (7.4 +- 1.7 vs. 16.4 +- 1.8mmHg).	1,2-Dimethylhydrazine	6-9	hypocretin neuropeptide precursor	Rattus norvegicus	153-161
29104046-10	2018	In conclusion, orexins regulated cardiovascular functions through OX1R/OX2R- or OX1R-mediated mechanisms at different locations in the DMH.	1,2-Dimethylhydrazine	135-138	hypocretin receptor 1	Rattus norvegicus	80-84
29108773-12	2017	Moreover the increased expressions of mast cells, argyrophilic nucleolar organizer regions (AgNORs), proliferating cell nuclear antigen (PCNA) and cyclin D1 observed in the DMH-alone-exposed rats were reverted and were comparable with those of the control rats, when treated with AA.	1,2-Dimethylhydrazine	173-176	proliferating cell nuclear antigen	Rattus norvegicus	101-135
29108773-12	2017	Moreover the increased expressions of mast cells, argyrophilic nucleolar organizer regions (AgNORs), proliferating cell nuclear antigen (PCNA) and cyclin D1 observed in the DMH-alone-exposed rats were reverted and were comparable with those of the control rats, when treated with AA.	1,2-Dimethylhydrazine	173-176	proliferating cell nuclear antigen	Rattus norvegicus	137-141
29108773-12	2017	Moreover the increased expressions of mast cells, argyrophilic nucleolar organizer regions (AgNORs), proliferating cell nuclear antigen (PCNA) and cyclin D1 observed in the DMH-alone-exposed rats were reverted and were comparable with those of the control rats, when treated with AA.	1,2-Dimethylhydrazine	173-176	cyclin D1	Rattus norvegicus	147-156
28730826-4	2017	The lower proportions of hybrid fiber types and especially that of type 1/2x in most gastrocnemius samples of DMH-treated rats resulted in a shift towards a single MyHC isoform expression, but the extent and pattern of the MyHC isoform shift varied across the different gastrocnemius samples.	1,2-Dimethylhydrazine	110-113	myosin heavy chain 13	Rattus norvegicus	164-168
28730826-4	2017	The lower proportions of hybrid fiber types and especially that of type 1/2x in most gastrocnemius samples of DMH-treated rats resulted in a shift towards a single MyHC isoform expression, but the extent and pattern of the MyHC isoform shift varied across the different gastrocnemius samples.	1,2-Dimethylhydrazine	110-113	myosin heavy chain 13	Rattus norvegicus	223-227
28315345-0	2017	Inositol hexaphosphate suppresses colorectal cancer cell proliferation via the Akt/GSK-3beta/beta-catenin signaling cascade in a 1,2-dimethylhydrazine-induced rat model.	1,2-Dimethylhydrazine	129-150	AKT serine/threonine kinase 1	Rattus norvegicus	79-82
28936198-8	2017	We found that social isolation modifies the pattern of CLOCK expression in GnIH neurons in the DMH.	1,2-Dimethylhydrazine	95-98	clock circadian regulator	Rattus norvegicus	55-60
29113196-0	2017	Inhibition of DMH-DSS-induced colorectal cancer by liposomal bovine lactoferrin in rats.	1,2-Dimethylhydrazine	14-17	lactotransferrin	Bos taurus	68-79
28435125-2	2017	Intra-DMH administration of the CRF type 1 receptor (CRFR1) antagonist antalarmin induced anxiolytic-like effects and counteracted the anxiogenic effects of CRF.	1,2-Dimethylhydrazine	6-9	corticotropin releasing hormone receptor 1	Rattus norvegicus	53-58
28435125-4	2017	For that, male wistar rats were treated with CRFR1 and CRFR2-modulating drugs in the DMH or VMH, another hypothalamic nucleus implicated with defensive and emotional behavior, and tested in the ETM for inhibitory avoidance and escape measurements.	1,2-Dimethylhydrazine	85-88	corticotropin releasing hormone receptor 2	Rattus norvegicus	55-60
28315345-0	2017	Inositol hexaphosphate suppresses colorectal cancer cell proliferation via the Akt/GSK-3beta/beta-catenin signaling cascade in a 1,2-dimethylhydrazine-induced rat model.	1,2-Dimethylhydrazine	129-150	glycogen synthase kinase 3 beta	Rattus norvegicus	83-92
28315345-0	2017	Inositol hexaphosphate suppresses colorectal cancer cell proliferation via the Akt/GSK-3beta/beta-catenin signaling cascade in a 1,2-dimethylhydrazine-induced rat model.	1,2-Dimethylhydrazine	129-150	catenin beta 1	Rattus norvegicus	93-105
28583050-6	2017	Intra-DMH injection of the selective MOR agonist DAMGO (0.3 nmol) also inhibited escape behavior, and a previous injection of the 5-HT1AR antagonist WAY-100635 (0.37 nmol) counteracted this panicolytic-like effect.	1,2-Dimethylhydrazine	6-9	opioid receptor mu 1	Homo sapiens	37-40
28575002-6	2017	On PND 90, maternal environment during the cross-fostering period had a major effect on DMH Npy expression.	1,2-Dimethylhydrazine	88-91	neuropeptide Y	Rattus norvegicus	92-95
28575002-8	2017	Reduced expression of Npy in the DMH of LdOp rats was consistent with their reduction of body weight compared to OdOp rats.	1,2-Dimethylhydrazine	33-36	neuropeptide Y	Rattus norvegicus	22-25
28575002-11	2017	Together, our results demonstrate effects of both genotype and early postnatal environment on obesity of OLETF rats and further suggest an important role of DMH NPY in the development of obesity of OLETF rats.	1,2-Dimethylhydrazine	157-160	neuropeptide Y	Rattus norvegicus	161-164
28296653-8	2017	The number of nNOS-positive cells was significantly increased, 56.5%, in PVN and, 119%, in DMH, but not in ventromedial hypothalamus.	1,2-Dimethylhydrazine	91-94	nitric oxide synthase 1	Rattus norvegicus	14-18
28284729-6	2017	Expression of beta-catenin, COX-2, VEGF, and cyclin D1 was significantly higher in the combined DMH and DEHP-treated rats by comparison to that of the DMH group.	1,2-Dimethylhydrazine	96-99	catenin beta 1	Rattus norvegicus	14-26
28284729-6	2017	Expression of beta-catenin, COX-2, VEGF, and cyclin D1 was significantly higher in the combined DMH and DEHP-treated rats by comparison to that of the DMH group.	1,2-Dimethylhydrazine	96-99	vascular endothelial growth factor A	Rattus norvegicus	35-39
28284729-6	2017	Expression of beta-catenin, COX-2, VEGF, and cyclin D1 was significantly higher in the combined DMH and DEHP-treated rats by comparison to that of the DMH group.	1,2-Dimethylhydrazine	96-99	cyclin D1	Rattus norvegicus	45-54
27931809-0	2016	Report on the rat Pig-a assay using an anti-rat erythroid marker HIS49 antibody in a single dose study of 1,2-dimethylhydrazine.	1,2-Dimethylhydrazine	106-127	phosphatidylinositol glycan anchor biosynthesis class A	Sus scrofa	18-23
27989504-2	2017	The present study aims to explore the impact of morin and/or esculetin on c-myc induced energy metabolism in 1,2-dimethylhydrazine (DMH) induced colon cancer in rats.	1,2-Dimethylhydrazine	109-130	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	74-79
27989504-2	2017	The present study aims to explore the impact of morin and/or esculetin on c-myc induced energy metabolism in 1,2-dimethylhydrazine (DMH) induced colon cancer in rats.	1,2-Dimethylhydrazine	132-135	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	74-79
28443209-3	2017	Rats with DMH-induced colon adenocarcinomas had elevated levels of serum glucose, insulin, insulin-like growth factor-1, total cholesterol, triglycerides, catalase, malonic dialdehyde, glycated hemoglobin, aspartate aminotransferase, and alanine aminotransferase and decreased hemoglobin.	1,2-Dimethylhydrazine	10-13	insulin-like growth factor 1	Rattus norvegicus	91-119
28443209-3	2017	Rats with DMH-induced colon adenocarcinomas had elevated levels of serum glucose, insulin, insulin-like growth factor-1, total cholesterol, triglycerides, catalase, malonic dialdehyde, glycated hemoglobin, aspartate aminotransferase, and alanine aminotransferase and decreased hemoglobin.	1,2-Dimethylhydrazine	10-13	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	206-232
27988423-2	2017	We investigated the MTSS1 gene, identified as hypermethylated by differential methylation hybridization (DMH).	1,2-Dimethylhydrazine	105-108	MTSS I-BAR domain containing 1	Homo sapiens	20-25
27729278-7	2017	Finally, strong correlation between c-fos expression and MEMRI signal increase rate was observed in the ARC, VMH and DMH.	1,2-Dimethylhydrazine	117-120	FBJ osteosarcoma oncogene	Mus musculus	36-41
27805869-1	2016	Recent evidence has shown that alterations in dorsomedial hypothalamic (DMH) neuropeptide Y (NPY) signaling influence glucose homeostasis, but the mechanism through which DMH NPY acts to affect glucose homeostasis remains unclear.	1,2-Dimethylhydrazine	72-75	neuropeptide Y	Rattus norvegicus	77-91
27805869-1	2016	Recent evidence has shown that alterations in dorsomedial hypothalamic (DMH) neuropeptide Y (NPY) signaling influence glucose homeostasis, but the mechanism through which DMH NPY acts to affect glucose homeostasis remains unclear.	1,2-Dimethylhydrazine	72-75	neuropeptide Y	Rattus norvegicus	93-96
27805869-2	2016	Here we report that DMH NPY descending signals to the dorsal motor nucleus of the vagus (DMV) modulate hepatic insulin sensitivity to control hepatic glucose production in rats.	1,2-Dimethylhydrazine	20-23	neuropeptide Y	Rattus norvegicus	24-27
27805869-3	2016	Using the hyperinsulinemic-euglycemic clamp, we revealed that knockdown of NPY in the DMH by adeno-associated virus-mediated NPY-specific RNAi promoted insulin"s action on suppression of hepatic glucose production.	1,2-Dimethylhydrazine	86-89	neuropeptide Y	Rattus norvegicus	75-78
27805869-3	2016	Using the hyperinsulinemic-euglycemic clamp, we revealed that knockdown of NPY in the DMH by adeno-associated virus-mediated NPY-specific RNAi promoted insulin"s action on suppression of hepatic glucose production.	1,2-Dimethylhydrazine	86-89	neuropeptide Y	Rattus norvegicus	125-128
27805869-4	2016	This knockdown silenced DMH NPY descending signals to the DMV, leading to an elevation of hepatic vagal innervation.	1,2-Dimethylhydrazine	24-27	neuropeptide Y	Rattus norvegicus	28-31
27805869-5	2016	Hepatic vagotomy abolished the inhibitory effect of DMH NPY knockdown on hepatic glucose production, but this glycemic effect was not affected by vagal deafferentation.	1,2-Dimethylhydrazine	52-55	neuropeptide Y	Rattus norvegicus	56-59
27805869-6	2016	Together, these results demonstrate a distinct role for DMH NPY in the regulation of glucose homeostasis through the hepatic vagal efferents and insulin action on hepatic glucose production.	1,2-Dimethylhydrazine	56-59	neuropeptide Y	Rattus norvegicus	60-63
27255553-5	2016	Alcian blue staining in colonic tissue reveals that mucin secretion was found to be depleted in DMH-induced group of animals.	1,2-Dimethylhydrazine	96-99	solute carrier family 13 member 2	Rattus norvegicus	52-57
27255553-10	2016	Colonic stem cell marker protein CD133, CD44, and beta-catenin expressions were found to be increased in DMH-induced group of animals as compared to control group of rats.	1,2-Dimethylhydrazine	105-108	prominin 1	Rattus norvegicus	33-38
27255553-10	2016	Colonic stem cell marker protein CD133, CD44, and beta-catenin expressions were found to be increased in DMH-induced group of animals as compared to control group of rats.	1,2-Dimethylhydrazine	105-108	CD44 molecule (Indian blood group)	Rattus norvegicus	40-44
27255553-10	2016	Colonic stem cell marker protein CD133, CD44, and beta-catenin expressions were found to be increased in DMH-induced group of animals as compared to control group of rats.	1,2-Dimethylhydrazine	105-108	catenin beta 1	Rattus norvegicus	50-62
27534875-4	2016	Since activation of catecholaminergic neurons within the nucleus of solitary tract (NTS) contributes to the feeding effects of CCK, we hypothesized that DMH NPY modulates NTS neural catecholaminergic signaling to affect food intake.	1,2-Dimethylhydrazine	153-156	cholecystokinin	Rattus norvegicus	127-130
27534875-4	2016	Since activation of catecholaminergic neurons within the nucleus of solitary tract (NTS) contributes to the feeding effects of CCK, we hypothesized that DMH NPY modulates NTS neural catecholaminergic signaling to affect food intake.	1,2-Dimethylhydrazine	153-156	neuropeptide Y	Rattus norvegicus	157-160
27534875-5	2016	We used an adeno-associated virus system to manipulate DMH NPY gene expression in rats to examine this pathway.	1,2-Dimethylhydrazine	55-58	neuropeptide Y	Rattus norvegicus	59-62
27534875-6	2016	Viral-mediated hrGFP anterograde tracing revealed that DMH NPY neurons project to the NTS; the projections were in close proximity to catecholaminergic neurons, and some contained NPY.	1,2-Dimethylhydrazine	55-58	neuropeptide Y	Rattus norvegicus	59-62
27534875-6	2016	Viral-mediated hrGFP anterograde tracing revealed that DMH NPY neurons project to the NTS; the projections were in close proximity to catecholaminergic neurons, and some contained NPY.	1,2-Dimethylhydrazine	55-58	neuropeptide Y	Rattus norvegicus	180-183
27534875-8	2016	Knockdown of DMH NPY produced the opposite effects.	1,2-Dimethylhydrazine	13-16	neuropeptide Y	Rattus norvegicus	17-20
27534875-10	2016	Taken together, these results demonstrate that DMH NPY descending signals affect CCK-induced satiety, at least in part, via modulation of NTS catecholaminergic neuronal signaling.	1,2-Dimethylhydrazine	47-50	neuropeptide Y	Rattus norvegicus	51-54
27534875-10	2016	Taken together, these results demonstrate that DMH NPY descending signals affect CCK-induced satiety, at least in part, via modulation of NTS catecholaminergic neuronal signaling.	1,2-Dimethylhydrazine	47-50	cholecystokinin	Rattus norvegicus	81-84
27624753-2	2016	It has been shown before that the GLUT-2 transporter is highly expressed in both beta-cells and hepatocytes and that D-mannoheptulose (DMH) has high uptake specificity for the GLUT-2 transporter.	1,2-Dimethylhydrazine	135-138	solute carrier family 2 member 2	Homo sapiens	34-40
27624753-2	2016	It has been shown before that the GLUT-2 transporter is highly expressed in both beta-cells and hepatocytes and that D-mannoheptulose (DMH) has high uptake specificity for the GLUT-2 transporter.	1,2-Dimethylhydrazine	135-138	solute carrier family 2 member 2	Homo sapiens	176-182
27470345-13	2016	The present results highlighted an increase in angiogenic markers and cell proliferation in the DMH-diabetic group in comparison with the control group with greater expression of endothelial marker (CD34) and Ki-67 in colon tissue.	1,2-Dimethylhydrazine	96-99	CD34 antigen	Mus musculus	199-203
27273815-8	2016	Collectively, our main findings indicate that high-fat diet induced-hypertension and autonomic imbalance are associated to an upregulation of CART levels in the DMH of mice.	1,2-Dimethylhydrazine	161-164	CART prepropeptide	Mus musculus	142-146
27466499-11	2016	Expression of endoglin protein was significantly elevated in the DMH group compared to controls (p&lt;0.001).	1,2-Dimethylhydrazine	65-68	endoglin	Homo sapiens	14-22
26749090-7	2016	DMH treatment with 8-OH-DPAT decreased escape responses, which strongly suggests that the 5-HT1A receptor modulates the defensive responses.	1,2-Dimethylhydrazine	0-3	5-hydroxytryptamine receptor 1A	Homo sapiens	90-105
27053000-6	2016	ICV TTR decreased neuropeptide Y (NPY) levels in the DMH and the paraventricular nucleus (P &lt; 0.05).	1,2-Dimethylhydrazine	53-56	transthyretin	Rattus norvegicus	4-7
27053000-6	2016	ICV TTR decreased neuropeptide Y (NPY) levels in the DMH and the paraventricular nucleus (P &lt; 0.05).	1,2-Dimethylhydrazine	53-56	neuropeptide Y	Rattus norvegicus	18-32
27053000-6	2016	ICV TTR decreased neuropeptide Y (NPY) levels in the DMH and the paraventricular nucleus (P &lt; 0.05).	1,2-Dimethylhydrazine	53-56	neuropeptide Y	Rattus norvegicus	34-37
27053000-7	2016	Chronic icv infusion of TTR in Otsuka Long-Evans Tokushima Fatty rats reversed hyperphagia and obesity and reduced DMH NPY levels.	1,2-Dimethylhydrazine	115-118	transthyretin	Rattus norvegicus	24-27
27461646-7	2016	Administration of carvacrol to DMH-treated rats significantly decreased the tumor incidence and the number of ACF and bacterial enzymes with enhancement of colonic lipid peroxidation, GPx, SOD, and CAT activities.	1,2-Dimethylhydrazine	31-34	catalase	Rattus norvegicus	198-201
26898448-8	2016	It was found that DMH-treated animals were having an over-expression of pro-inflammatory enzymes, aberrant nuclear localization of activated cell survival transcription factor, NF-kappaB and suppression of anti-inflammatory transcription factor PPAR-gamma, thereby suggesting a marked role of inflammation in the tumor progression.	1,2-Dimethylhydrazine	18-21	nuclear factor kappa B subunit 1	Homo sapiens	177-186
26898448-8	2016	It was found that DMH-treated animals were having an over-expression of pro-inflammatory enzymes, aberrant nuclear localization of activated cell survival transcription factor, NF-kappaB and suppression of anti-inflammatory transcription factor PPAR-gamma, thereby suggesting a marked role of inflammation in the tumor progression.	1,2-Dimethylhydrazine	18-21	peroxisome proliferator activated receptor gamma	Homo sapiens	245-255
26749090-11	2016	The present data suggest that the ascending pathways from the DRN to the DMH modulate panic-like defensive behaviours and mediate antinociceptive phenomenon by recruiting 5-HT1A receptor in the MH.	1,2-Dimethylhydrazine	73-76	5-hydroxytryptamine receptor 1A	Homo sapiens	171-186
26482805-4	2015	In this study, we aimed to understand the ability of TAX, to modulate the Nrf2, inflammatory and Wnt/beta-catenin cascades on 1, 2-dimethyl hydrazine (DMH)-induced mouse colon carcinogenesis.	1,2-Dimethylhydrazine	126-149	nuclear factor, erythroid derived 2, like 2	Mus musculus	74-78
27910782-7	2016	Analysis by immunofluorescence and western blotting shows that the expression of VEGF, MMP-2, and MMP-9 was found to be significantly elevated in the DMH- treated group and notably lowered by NSAID coadministration.	1,2-Dimethylhydrazine	150-153	matrix metallopeptidase 2	Rattus norvegicus	87-92
27910782-7	2016	Analysis by immunofluorescence and western blotting shows that the expression of VEGF, MMP-2, and MMP-9 was found to be significantly elevated in the DMH- treated group and notably lowered by NSAID coadministration.	1,2-Dimethylhydrazine	150-153	matrix metallopeptidase 9	Rattus norvegicus	98-103
27910782-10	2016	Results from the present study indicate the potential role of these chemokines along with VEGF and MMPs against angiogenesis in DMH-induced cancer.	1,2-Dimethylhydrazine	128-131	vascular endothelial growth factor A	Rattus norvegicus	90-94
27910782-10	2016	Results from the present study indicate the potential role of these chemokines along with VEGF and MMPs against angiogenesis in DMH-induced cancer.	1,2-Dimethylhydrazine	128-131	matrix metallopeptidase 2	Rattus norvegicus	99-103
25926526-0	2016	Radioprotection of 1,2-dimethylhydrazine-initiated colon cancer in rats using low-dose gamma rays by modulating multidrug resistance-1, cytokeratin 20, and beta-catenin expression.	1,2-Dimethylhydrazine	19-40	keratin 20	Rattus norvegicus	136-150
25926526-0	2016	Radioprotection of 1,2-dimethylhydrazine-initiated colon cancer in rats using low-dose gamma rays by modulating multidrug resistance-1, cytokeratin 20, and beta-catenin expression.	1,2-Dimethylhydrazine	19-40	catenin beta 1	Rattus norvegicus	156-168
25926526-8	2016	Moreover, gamma ray reduced the expressions of multidrug resistance 1 (MDR1), beta-catenin, and cytokeratin 20 (CK20) those increased in DMH-treated rats.	1,2-Dimethylhydrazine	137-140	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	47-69
25926526-8	2016	Moreover, gamma ray reduced the expressions of multidrug resistance 1 (MDR1), beta-catenin, and cytokeratin 20 (CK20) those increased in DMH-treated rats.	1,2-Dimethylhydrazine	137-140	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	71-75
25926526-8	2016	Moreover, gamma ray reduced the expressions of multidrug resistance 1 (MDR1), beta-catenin, and cytokeratin 20 (CK20) those increased in DMH-treated rats.	1,2-Dimethylhydrazine	137-140	catenin beta 1	Rattus norvegicus	78-90
25926526-8	2016	Moreover, gamma ray reduced the expressions of multidrug resistance 1 (MDR1), beta-catenin, and cytokeratin 20 (CK20) those increased in DMH-treated rats.	1,2-Dimethylhydrazine	137-140	keratin 20	Rattus norvegicus	96-110
25926526-8	2016	Moreover, gamma ray reduced the expressions of multidrug resistance 1 (MDR1), beta-catenin, and cytokeratin 20 (CK20) those increased in DMH-treated rats.	1,2-Dimethylhydrazine	137-140	keratin 20	Rattus norvegicus	112-116
25926526-12	2016	In conclusion, the present results showed that low-dose gamma ray significantly inhibited DMH-induced colon carcinogenesis in rats by modulating CK20, MDR1, and beta-catenin expression but not survivin expression.	1,2-Dimethylhydrazine	90-93	keratin 20	Rattus norvegicus	145-149
25926526-12	2016	In conclusion, the present results showed that low-dose gamma ray significantly inhibited DMH-induced colon carcinogenesis in rats by modulating CK20, MDR1, and beta-catenin expression but not survivin expression.	1,2-Dimethylhydrazine	90-93	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	151-155
25926526-12	2016	In conclusion, the present results showed that low-dose gamma ray significantly inhibited DMH-induced colon carcinogenesis in rats by modulating CK20, MDR1, and beta-catenin expression but not survivin expression.	1,2-Dimethylhydrazine	90-93	catenin beta 1	Rattus norvegicus	161-173
26561644-11	2016	Together, these results demonstrate a therapeutic action of DMH NPY knockdown against obesity and impaired glucose homeostasis in rats, providing a potential target for the treatment of obesity and diabetes.	1,2-Dimethylhydrazine	60-63	neuropeptide Y	Rattus norvegicus	64-67
27840820-1	2016	Apc-mutated Pirc rats, spontaneously developing intestinal tumours, are resistant to 1,2-dimethylhydrazine- (DMH-) induced colon apoptosis.	1,2-Dimethylhydrazine	85-106	APC regulator of WNT signaling pathway	Rattus norvegicus	0-3
27910782-7	2016	Analysis by immunofluorescence and western blotting shows that the expression of VEGF, MMP-2, and MMP-9 was found to be significantly elevated in the DMH- treated group and notably lowered by NSAID coadministration.	1,2-Dimethylhydrazine	150-153	vascular endothelial growth factor A	Rattus norvegicus	81-85
27232632-5	2016	In DMH-treated rats, the extracts partially normalized the levels of FRAP, CYP450, beta-catenin, and GST.	1,2-Dimethylhydrazine	3-6	catenin beta 1	Rattus norvegicus	83-95
26482805-4	2015	In this study, we aimed to understand the ability of TAX, to modulate the Nrf2, inflammatory and Wnt/beta-catenin cascades on 1, 2-dimethyl hydrazine (DMH)-induced mouse colon carcinogenesis.	1,2-Dimethylhydrazine	126-149	catenin (cadherin associated protein), beta 1	Mus musculus	101-113
26482805-4	2015	In this study, we aimed to understand the ability of TAX, to modulate the Nrf2, inflammatory and Wnt/beta-catenin cascades on 1, 2-dimethyl hydrazine (DMH)-induced mouse colon carcinogenesis.	1,2-Dimethylhydrazine	151-154	nuclear factor, erythroid derived 2, like 2	Mus musculus	74-78
26482805-4	2015	In this study, we aimed to understand the ability of TAX, to modulate the Nrf2, inflammatory and Wnt/beta-catenin cascades on 1, 2-dimethyl hydrazine (DMH)-induced mouse colon carcinogenesis.	1,2-Dimethylhydrazine	151-154	catenin (cadherin associated protein), beta 1	Mus musculus	101-113
24740923-2	2015	The aim of this study was to evaluate the impact of silibinin on the colonic expression of the caudal-type homeobox transcription factor (CDX2) an intestine specific tumor suppressor gene and its downstream targets in the colon of rats challenged with 1,2 dimethyl hydrazine (DMH).	1,2-Dimethylhydrazine	252-274	caudal type homeo box 2	Rattus norvegicus	138-142
26073698-5	2015	Neurons expressing both NPW and NPY mRNAs begin to emerge in the DMH at about postnatal day 0 (P-0) through P-3.	1,2-Dimethylhydrazine	65-68	neuropeptide W	Mus musculus	24-27
26073698-5	2015	Neurons expressing both NPW and NPY mRNAs begin to emerge in the DMH at about postnatal day 0 (P-0) through P-3.	1,2-Dimethylhydrazine	65-68	neuropeptide Y	Mus musculus	32-35
26073698-9	2015	A cross of NPW-iCre knock-in mice with a Cre-dependent tdTomato reporter line revealed that more than half of the reporter-positive neurons in the adult DMH, which mature from the transiently NPW-expressing neurons, are sensitive to peripherally administrated leptin.	1,2-Dimethylhydrazine	153-156	neuropeptide W	Mus musculus	11-14
26073698-9	2015	A cross of NPW-iCre knock-in mice with a Cre-dependent tdTomato reporter line revealed that more than half of the reporter-positive neurons in the adult DMH, which mature from the transiently NPW-expressing neurons, are sensitive to peripherally administrated leptin.	1,2-Dimethylhydrazine	153-156	neuropeptide W	Mus musculus	192-195
25546159-4	2015	We found neuropeptide VF precursor (Npvf), PR domain containing 13 (Prdm13), and SK1 family transcriptional corepressor (Skor1) as DMH-enriched genes.	1,2-Dimethylhydrazine	131-134	neuropeptide VF precursor	Mus musculus	36-40
25546159-4	2015	We found neuropeptide VF precursor (Npvf), PR domain containing 13 (Prdm13), and SK1 family transcriptional corepressor (Skor1) as DMH-enriched genes.	1,2-Dimethylhydrazine	131-134	PR domain containing 13	Mus musculus	68-74
25546159-4	2015	We found neuropeptide VF precursor (Npvf), PR domain containing 13 (Prdm13), and SK1 family transcriptional corepressor (Skor1) as DMH-enriched genes.	1,2-Dimethylhydrazine	131-134	SKI family transcriptional corepressor 1	Mus musculus	121-126
25546159-5	2015	Particularly, Prdm13, a member of the Prdm family of transcription regulators, was specifically expressed in the compact region of the DMH (DMC), where Nk2 homeobox 1 (Nkx2-1) is predominantly expressed.	1,2-Dimethylhydrazine	135-138	PR domain containing 13	Mus musculus	14-20
25546159-5	2015	Particularly, Prdm13, a member of the Prdm family of transcription regulators, was specifically expressed in the compact region of the DMH (DMC), where Nk2 homeobox 1 (Nkx2-1) is predominantly expressed.	1,2-Dimethylhydrazine	135-138	NK2 homeobox 1	Mus musculus	152-166
25546159-5	2015	Particularly, Prdm13, a member of the Prdm family of transcription regulators, was specifically expressed in the compact region of the DMH (DMC), where Nk2 homeobox 1 (Nkx2-1) is predominantly expressed.	1,2-Dimethylhydrazine	135-138	NK2 homeobox 1	Mus musculus	168-174
25546159-7	2015	Prdm13 expression also showed diurnal oscillation and was significantly upregulated in the DMH of long-lived BRASTO mice.	1,2-Dimethylhydrazine	91-94	PR domain containing 13	Mus musculus	0-6
25546159-9	2015	Interestingly, DMH-specific Prdm13-knockdown mice showed significantly reduced wake time during the dark period and decreased sleep quality, which was defined by the quantity of electroencephalogram delta activity during NREM sleep.	1,2-Dimethylhydrazine	15-18	PR domain containing 13	Mus musculus	28-34
25546159-10	2015	DMH-specific Prdm13-knockdown mice also exhibited progressive increases in body weight and adiposity.	1,2-Dimethylhydrazine	0-3	PR domain containing 13	Mus musculus	13-19
25546159-11	2015	Our findings indicate that Prdm13/Nkx2-1-mediated signaling in the DMC declines with advanced age, leading to decreased sleep quality and increased adiposity, which mimic age-associated pathophysiology, and provides a potential link to DMH-mediated aging and longevity control in mammals.	1,2-Dimethylhydrazine	236-239	PR domain containing 13	Mus musculus	27-33
25546159-11	2015	Our findings indicate that Prdm13/Nkx2-1-mediated signaling in the DMC declines with advanced age, leading to decreased sleep quality and increased adiposity, which mimic age-associated pathophysiology, and provides a potential link to DMH-mediated aging and longevity control in mammals.	1,2-Dimethylhydrazine	236-239	NK2 homeobox 1	Mus musculus	34-40
25536541-3	2015	Application of DMH triggered the production of pro-inflammatory cytokines IL-2, IL-6, IL-17, and TNF-alpha, expression of pro-inflammatory mediators NF-kappaB, COX-2 and iNOS and caused depletion of goblet cells.	1,2-Dimethylhydrazine	15-18	interleukin 2	Rattus norvegicus	74-78
25536541-3	2015	Application of DMH triggered the production of pro-inflammatory cytokines IL-2, IL-6, IL-17, and TNF-alpha, expression of pro-inflammatory mediators NF-kappaB, COX-2 and iNOS and caused depletion of goblet cells.	1,2-Dimethylhydrazine	15-18	interleukin 6	Rattus norvegicus	80-84
25536541-3	2015	Application of DMH triggered the production of pro-inflammatory cytokines IL-2, IL-6, IL-17, and TNF-alpha, expression of pro-inflammatory mediators NF-kappaB, COX-2 and iNOS and caused depletion of goblet cells.	1,2-Dimethylhydrazine	15-18	interleukin 17A	Rattus norvegicus	86-91
25536541-3	2015	Application of DMH triggered the production of pro-inflammatory cytokines IL-2, IL-6, IL-17, and TNF-alpha, expression of pro-inflammatory mediators NF-kappaB, COX-2 and iNOS and caused depletion of goblet cells.	1,2-Dimethylhydrazine	15-18	tumor necrosis factor	Rattus norvegicus	97-106
25536541-3	2015	Application of DMH triggered the production of pro-inflammatory cytokines IL-2, IL-6, IL-17, and TNF-alpha, expression of pro-inflammatory mediators NF-kappaB, COX-2 and iNOS and caused depletion of goblet cells.	1,2-Dimethylhydrazine	15-18	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	160-165
25536541-3	2015	Application of DMH triggered the production of pro-inflammatory cytokines IL-2, IL-6, IL-17, and TNF-alpha, expression of pro-inflammatory mediators NF-kappaB, COX-2 and iNOS and caused depletion of goblet cells.	1,2-Dimethylhydrazine	15-18	nitric oxide synthase 2	Rattus norvegicus	170-174
25239511-3	2015	In this study, the therapeutic efficacy of anti-interleukin (IL)-17A by anti-IL-17A antibody injection on the development of CAC was assessed in 1,2-dimethylhydrazine (DMH) plus dextran sulfate sodium (DSS) induced CAC mouse model.	1,2-Dimethylhydrazine	145-166	interleukin 17A	Mus musculus	77-83
25239511-4	2015	The results showed that mice dosed with DMH plus DSS for 10 weeks evoked high degree dysplastic lesion in the large bowel that accompanied with significant increased IL-17A expression, proliferation index and inflammation degree in mice.	1,2-Dimethylhydrazine	40-43	interleukin 17A	Mus musculus	166-172
26271242-5	2015	On the other hand, supplementation with AI, DMH-treated rats resulted in a significant decrease in the levels of lipid peroxidation but caused a significant increase in the levels of GSH as well in the activities of GR, GST, SOD, CAT and GPx.	1,2-Dimethylhydrazine	44-47	catalase	Rattus norvegicus	230-233
26025172-2	2015	The aim of this study was to investigate the impact of Lactobacillus salivarius Ren (Ren) in modulating colonic microbiota structure and colon cancer incidence in a rat model after injection with 1,2-dimethyl hydrazine (DMH).	1,2-Dimethylhydrazine	196-218	renin	Rattus norvegicus	80-83
26025172-2	2015	The aim of this study was to investigate the impact of Lactobacillus salivarius Ren (Ren) in modulating colonic microbiota structure and colon cancer incidence in a rat model after injection with 1,2-dimethyl hydrazine (DMH).	1,2-Dimethylhydrazine	220-223	renin	Rattus norvegicus	80-83
26025172-3	2015	The results indicated that oral administration of Ren could effectively suppress DMH-induced colonic carcinogenesis.	1,2-Dimethylhydrazine	81-84	renin	Rattus norvegicus	50-53
26025172-5	2015	Using denaturing gradient gel electrophoresis and Real-time PCR combined with multivariate statistical methods, we demonstrated that injection with DMH significantly altered the rat gut microbiota, while Ren counteracted these DMH-induced adverse effects and promoted reversion of the gut microbiota close to the healthy state.	1,2-Dimethylhydrazine	227-230	renin	Rattus norvegicus	204-207
25872647-10	2015	The results indicated that vaccination with recombinant attenuated Salmonella harboring the CEACAM6 and 4-1BBL gene efficiently increased the number of CD3+CD8+ TIL and NK cells, decreased the number of FOXP3 cells and inhibited the development of DMH-induced colorectal cancer in rats.	1,2-Dimethylhydrazine	248-251	CEA cell adhesion molecule 6	Rattus norvegicus	92-99
25586077-6	2015	Blood lipid peroxidation levels exhibited a marked increase while antioxidant enzyme activities of superoxide dismutase, catalase, glucose-6-phosphate dehydrogenase and glutathione peroxidase were found to be reduced in DMH-treated rats.	1,2-Dimethylhydrazine	220-223	catalase	Rattus norvegicus	121-129
25586077-6	2015	Blood lipid peroxidation levels exhibited a marked increase while antioxidant enzyme activities of superoxide dismutase, catalase, glucose-6-phosphate dehydrogenase and glutathione peroxidase were found to be reduced in DMH-treated rats.	1,2-Dimethylhydrazine	220-223	glucose-6-phosphate dehydrogenase	Rattus norvegicus	131-164
25369245-7	2015	CD44 and carcinoembryonic antigen (CEA) staining demonstrated an approximately 3-fold increase in expression of both tissue markers for animals administered DBT, DBTO2, and DMH.	1,2-Dimethylhydrazine	173-176	CD44 molecule (Indian blood group)	Rattus norvegicus	0-4
25369245-7	2015	CD44 and carcinoembryonic antigen (CEA) staining demonstrated an approximately 3-fold increase in expression of both tissue markers for animals administered DBT, DBTO2, and DMH.	1,2-Dimethylhydrazine	173-176	CEA cell adhesion molecule 20	Rattus norvegicus	9-33
25369245-7	2015	CD44 and carcinoembryonic antigen (CEA) staining demonstrated an approximately 3-fold increase in expression of both tissue markers for animals administered DBT, DBTO2, and DMH.	1,2-Dimethylhydrazine	173-176	CEA cell adhesion molecule 20	Rattus norvegicus	35-38
25811420-7	2015	DMH treatment brought about a significant increase in the expression of COX-2.	1,2-Dimethylhydrazine	0-3	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	72-77
25825916-5	2015	Cyclin D1, cyclin E, CDK2, and CDK4 were overexpressed in DMH, whereas piroxicam and c-phycocyanin promoted the cell cycle arrest by downregulating them.	1,2-Dimethylhydrazine	58-61	cyclin D1	Rattus norvegicus	0-9
25825916-5	2015	Cyclin D1, cyclin E, CDK2, and CDK4 were overexpressed in DMH, whereas piroxicam and c-phycocyanin promoted the cell cycle arrest by downregulating them.	1,2-Dimethylhydrazine	58-61	cyclin E1	Rattus norvegicus	11-19
25825916-5	2015	Cyclin D1, cyclin E, CDK2, and CDK4 were overexpressed in DMH, whereas piroxicam and c-phycocyanin promoted the cell cycle arrest by downregulating them.	1,2-Dimethylhydrazine	58-61	cyclin dependent kinase 2	Rattus norvegicus	21-25
25825916-5	2015	Cyclin D1, cyclin E, CDK2, and CDK4 were overexpressed in DMH, whereas piroxicam and c-phycocyanin promoted the cell cycle arrest by downregulating them.	1,2-Dimethylhydrazine	58-61	cyclin-dependent kinase 4	Rattus norvegicus	31-35
25480301-4	2014	Leptin"s effects on BP are mediated by neuronal circuits in the dorsomedial hypothalamus (DMH), as blocking leptin with a specific antibody, antagonist, or inhibition of the activity of LepR-expressing neurons in the DMH caused a rapid reduction of BP in DIO mice, independent of changes in weight.	1,2-Dimethylhydrazine	90-93	leptin	Mus musculus	0-6
25480301-4	2014	Leptin"s effects on BP are mediated by neuronal circuits in the dorsomedial hypothalamus (DMH), as blocking leptin with a specific antibody, antagonist, or inhibition of the activity of LepR-expressing neurons in the DMH caused a rapid reduction of BP in DIO mice, independent of changes in weight.	1,2-Dimethylhydrazine	90-93	leptin	Mus musculus	108-114
25480301-4	2014	Leptin"s effects on BP are mediated by neuronal circuits in the dorsomedial hypothalamus (DMH), as blocking leptin with a specific antibody, antagonist, or inhibition of the activity of LepR-expressing neurons in the DMH caused a rapid reduction of BP in DIO mice, independent of changes in weight.	1,2-Dimethylhydrazine	90-93	leptin receptor	Mus musculus	186-190
25480301-4	2014	Leptin"s effects on BP are mediated by neuronal circuits in the dorsomedial hypothalamus (DMH), as blocking leptin with a specific antibody, antagonist, or inhibition of the activity of LepR-expressing neurons in the DMH caused a rapid reduction of BP in DIO mice, independent of changes in weight.	1,2-Dimethylhydrazine	217-220	leptin	Mus musculus	0-6
25480301-5	2014	Re-expression of LepRs in the DMH of DIO LepR-deficient mice caused an increase in BP.	1,2-Dimethylhydrazine	30-33	leptin receptor	Mus musculus	17-21
24532707-7	2014	Our results reveal that DMH alone treatment decreased the levels/activities of lipid peroxidation by-products such as thiobarbituric acid reactive substances, conjugated dienes and antioxidants such as superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase and reduced glutathione in the intestine and colonic tissues which were reversed on supplementation with SA.	1,2-Dimethylhydrazine	24-27	catalase	Rattus norvegicus	224-232
24532707-7	2014	Our results reveal that DMH alone treatment decreased the levels/activities of lipid peroxidation by-products such as thiobarbituric acid reactive substances, conjugated dienes and antioxidants such as superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase and reduced glutathione in the intestine and colonic tissues which were reversed on supplementation with SA.	1,2-Dimethylhydrazine	24-27	glutathione-disulfide reductase	Rattus norvegicus	234-255
25443739-5	2014	RESULTS: An upregulation of cell cycle regulators: cyclin D1/cdk4 and cyclin E/cdk2 and anti-apoptotic Bcl-2, along with the suppression of DNA repair enzymes: MLH1 and MSH2; tumour suppressors: p53, p21and Rb and pro-apoptotic proteins: Bax and Bad were observed in the DSS, DMH and DSS+DMH groups.	1,2-Dimethylhydrazine	276-279	cyclin D1	Homo sapiens	51-60
25443739-5	2014	RESULTS: An upregulation of cell cycle regulators: cyclin D1/cdk4 and cyclin E/cdk2 and anti-apoptotic Bcl-2, along with the suppression of DNA repair enzymes: MLH1 and MSH2; tumour suppressors: p53, p21and Rb and pro-apoptotic proteins: Bax and Bad were observed in the DSS, DMH and DSS+DMH groups.	1,2-Dimethylhydrazine	288-291	cyclin D1	Homo sapiens	51-60
25443739-5	2014	RESULTS: An upregulation of cell cycle regulators: cyclin D1/cdk4 and cyclin E/cdk2 and anti-apoptotic Bcl-2, along with the suppression of DNA repair enzymes: MLH1 and MSH2; tumour suppressors: p53, p21and Rb and pro-apoptotic proteins: Bax and Bad were observed in the DSS, DMH and DSS+DMH groups.	1,2-Dimethylhydrazine	288-291	BCL2 apoptosis regulator	Homo sapiens	103-108
25443739-5	2014	RESULTS: An upregulation of cell cycle regulators: cyclin D1/cdk4 and cyclin E/cdk2 and anti-apoptotic Bcl-2, along with the suppression of DNA repair enzymes: MLH1 and MSH2; tumour suppressors: p53, p21and Rb and pro-apoptotic proteins: Bax and Bad were observed in the DSS, DMH and DSS+DMH groups.	1,2-Dimethylhydrazine	288-291	mutL homolog 1	Homo sapiens	160-164
25443739-5	2014	RESULTS: An upregulation of cell cycle regulators: cyclin D1/cdk4 and cyclin E/cdk2 and anti-apoptotic Bcl-2, along with the suppression of DNA repair enzymes: MLH1 and MSH2; tumour suppressors: p53, p21and Rb and pro-apoptotic proteins: Bax and Bad were observed in the DSS, DMH and DSS+DMH groups.	1,2-Dimethylhydrazine	276-279	BCL2 apoptosis regulator	Homo sapiens	103-108
25443739-5	2014	RESULTS: An upregulation of cell cycle regulators: cyclin D1/cdk4 and cyclin E/cdk2 and anti-apoptotic Bcl-2, along with the suppression of DNA repair enzymes: MLH1 and MSH2; tumour suppressors: p53, p21and Rb and pro-apoptotic proteins: Bax and Bad were observed in the DSS, DMH and DSS+DMH groups.	1,2-Dimethylhydrazine	276-279	mutL homolog 1	Homo sapiens	160-164
25290207-6	2014	Results showed that intra-DMH administration of the 5-HT1A receptor agonist 8-OH-DPAT inhibited escape expression.	1,2-Dimethylhydrazine	26-29	5-hydroxytryptamine receptor 1A	Rattus norvegicus	52-58
25290207-10	2014	These results indicate that 5-HT1A receptors within the DMH may play a phasic inhibitory role on ETM escape expression.	1,2-Dimethylhydrazine	56-59	5-hydroxytryptamine receptor 1A	Rattus norvegicus	28-34
25290207-11	2014	As previously proposed, facilitation of 5-HT1A-mediated neurotransmission in the DMH may be involved in the mechanism of action of anti-panic compounds.	1,2-Dimethylhydrazine	81-84	5-hydroxytryptamine receptor 1A	Rattus norvegicus	40-46
24731269-10	2014	Extended lymphadenectomy (P = 0.038), vascular skeletonization (P = 0.012) and advanced TNM stage (P &lt; 0.001) were correlated with DMH.	1,2-Dimethylhydrazine	134-137	teneurin transmembrane protein 1	Homo sapiens	88-91
24718737-5	2014	Rats receiving only DMH dose showed increased lipid peroxidation in liver and intestinal tissues with reduced activity of antioxidant enzymes, i.e. superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx).	1,2-Dimethylhydrazine	20-23	catalase	Rattus norvegicus	176-184
24524423-10	2014	Administration of DMH in rats induced pre-neoplastic lesions (ACF and MDF) and increased the PCNA index in colorectal tissue.	1,2-Dimethylhydrazine	18-21	proliferating cell nuclear antigen	Rattus norvegicus	93-97
24908112-10	2014	DMH treatment significantly increased the activities of feacal and colonic bacterial enzymes (beta-glucosidase, beta-galactosidase, beta-glucuronidase, nitroreductase, sulphatase and mucinase).	1,2-Dimethylhydrazine	0-3	galactosidase, beta 1	Rattus norvegicus	112-130
24718737-5	2014	Rats receiving only DMH dose showed increased lipid peroxidation in liver and intestinal tissues with reduced activity of antioxidant enzymes, i.e. superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx).	1,2-Dimethylhydrazine	20-23	catalase	Rattus norvegicus	186-189
24639082-8	2014	CONCLUSION: Taken together, these data indicate that androgen excess promotes visceral adiposity with reduced POMC neuronal innervation in the DMH, reduced EE but without hyperphagia.	1,2-Dimethylhydrazine	143-146	pro-opiomelanocortin-alpha	Mus musculus	110-114
24281858-6	2014	Colon of the rats treated with DMH exhibited higher glycoconjugates and proliferation index such as elevated expressions of argyrophilic nucleolar organizing regions (AgNORs), proliferating cell nuclear antigen (PCNA), cyclin D1, matrix metalloproteins (MMP-2 and -9), and mast cells.	1,2-Dimethylhydrazine	31-34	proliferating cell nuclear antigen	Rattus norvegicus	176-210
24281858-6	2014	Colon of the rats treated with DMH exhibited higher glycoconjugates and proliferation index such as elevated expressions of argyrophilic nucleolar organizing regions (AgNORs), proliferating cell nuclear antigen (PCNA), cyclin D1, matrix metalloproteins (MMP-2 and -9), and mast cells.	1,2-Dimethylhydrazine	31-34	proliferating cell nuclear antigen	Rattus norvegicus	212-216
24281858-6	2014	Colon of the rats treated with DMH exhibited higher glycoconjugates and proliferation index such as elevated expressions of argyrophilic nucleolar organizing regions (AgNORs), proliferating cell nuclear antigen (PCNA), cyclin D1, matrix metalloproteins (MMP-2 and -9), and mast cells.	1,2-Dimethylhydrazine	31-34	matrix metallopeptidase 2	Rattus norvegicus	254-266
23928829-6	2014	Aloin pretreatment ameliorates the damaging effects induced by DMH through a protective mechanism that involved reduction in increased oxidative stress enzymes (p &lt; 0.001), ACF, MDF, cyclooxygenase-2, inducible nitric oxide synthase, interleukin-6, proliferating cell nuclear antigen protein expression, and tumor necrosis factor-alpha (p &lt; 0.001) release.	1,2-Dimethylhydrazine	63-66	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	186-235
23928829-6	2014	Aloin pretreatment ameliorates the damaging effects induced by DMH through a protective mechanism that involved reduction in increased oxidative stress enzymes (p &lt; 0.001), ACF, MDF, cyclooxygenase-2, inducible nitric oxide synthase, interleukin-6, proliferating cell nuclear antigen protein expression, and tumor necrosis factor-alpha (p &lt; 0.001) release.	1,2-Dimethylhydrazine	63-66	interleukin 6	Rattus norvegicus	237-250
23928829-6	2014	Aloin pretreatment ameliorates the damaging effects induced by DMH through a protective mechanism that involved reduction in increased oxidative stress enzymes (p &lt; 0.001), ACF, MDF, cyclooxygenase-2, inducible nitric oxide synthase, interleukin-6, proliferating cell nuclear antigen protein expression, and tumor necrosis factor-alpha (p &lt; 0.001) release.	1,2-Dimethylhydrazine	63-66	tumor necrosis factor	Rattus norvegicus	311-338
23562863-3	2013	We recently found that the orexigenic neuropeptide Y (NPY) in the DMH has specific actions on body adiposity and thermogenesis using a viral-mediated manipulation of NPY in the DMH.	1,2-Dimethylhydrazine	66-69	neuropeptide Y	Homo sapiens	38-52
23980536-5	2013	We have found that the orexigenic neuropeptide Y (NPY) in the DMH has distinct actions in modulating adiposity and BAT thermogenesis.	1,2-Dimethylhydrazine	62-65	neuropeptide Y	Homo sapiens	34-48
23980536-5	2013	We have found that the orexigenic neuropeptide Y (NPY) in the DMH has distinct actions in modulating adiposity and BAT thermogenesis.	1,2-Dimethylhydrazine	62-65	neuropeptide Y	Homo sapiens	50-53
23980536-6	2013	Knockdown of NPY in the DMH elevates the thermogenic activity of classic BAT and promotes the development of brown adipocytes in WAT, leading to increased thermogenesis.	1,2-Dimethylhydrazine	24-27	neuropeptide Y	Homo sapiens	13-16
24048859-5	2013	Surprisingly, electrophysiological experiments demonstrated that leptin directly depolarized and increased the firing rate of DMH NPY neurons in DIO mice.	1,2-Dimethylhydrazine	126-129	leptin	Mus musculus	65-71
24048859-5	2013	Surprisingly, electrophysiological experiments demonstrated that leptin directly depolarized and increased the firing rate of DMH NPY neurons in DIO mice.	1,2-Dimethylhydrazine	126-129	neuropeptide Y	Mus musculus	130-133
24048859-8	2013	Importantly, we also demonstrated that DMH NPY neurons coexpress cocaine amphetamine-regulated transcript (CART); however, CART mRNA expression in the DMH peaked earlier in the progression of DIO.	1,2-Dimethylhydrazine	39-42	neuropeptide Y	Mus musculus	43-46
24048859-8	2013	Importantly, we also demonstrated that DMH NPY neurons coexpress cocaine amphetamine-regulated transcript (CART); however, CART mRNA expression in the DMH peaked earlier in the progression of DIO.	1,2-Dimethylhydrazine	39-42	CART prepropeptide	Mus musculus	65-105
24048859-8	2013	Importantly, we also demonstrated that DMH NPY neurons coexpress cocaine amphetamine-regulated transcript (CART); however, CART mRNA expression in the DMH peaked earlier in the progression of DIO.	1,2-Dimethylhydrazine	39-42	CART prepropeptide	Mus musculus	107-111
24048859-8	2013	Importantly, we also demonstrated that DMH NPY neurons coexpress cocaine amphetamine-regulated transcript (CART); however, CART mRNA expression in the DMH peaked earlier in the progression of DIO.	1,2-Dimethylhydrazine	151-154	CART prepropeptide	Mus musculus	123-127
24048859-10	2013	First, NPY and CART are coexpressed in the same neurons within the DMH, and second, leptin stimulates DMH NPY neurons.	1,2-Dimethylhydrazine	67-70	neuropeptide Y	Mus musculus	7-10
24048859-10	2013	First, NPY and CART are coexpressed in the same neurons within the DMH, and second, leptin stimulates DMH NPY neurons.	1,2-Dimethylhydrazine	67-70	CART prepropeptide	Mus musculus	15-19
24048859-10	2013	First, NPY and CART are coexpressed in the same neurons within the DMH, and second, leptin stimulates DMH NPY neurons.	1,2-Dimethylhydrazine	102-105	leptin	Mus musculus	84-90
24048859-10	2013	First, NPY and CART are coexpressed in the same neurons within the DMH, and second, leptin stimulates DMH NPY neurons.	1,2-Dimethylhydrazine	102-105	neuropeptide Y	Mus musculus	106-109
24048859-11	2013	These studies suggest that during the progression of DIO, there is an unknown signal that drives the expression of the orexigenic NPY signal within the DMH, and that the chronic hyperleptinemia increases the activity of these NPY/CART neurons.	1,2-Dimethylhydrazine	152-155	neuropeptide Y	Mus musculus	130-133
24069171-0	2013	Tiam1 transgenic mice display increased tumor invasive and metastatic potential of colorectal cancer after 1,2-dimethylhydrazine treatment.	1,2-Dimethylhydrazine	107-128	T cell lymphoma invasion and metastasis 1	Mus musculus	0-5
24069171-8	2013	RESULTS: We successfully generated Tiam1/C1199-CopGFP transgenic mice and induced primary tumors in the intestine of both wild type and Tiam1 transgenic mice by DMH treatment.	1,2-Dimethylhydrazine	161-164	T cell lymphoma invasion and metastasis 1	Mus musculus	35-40
24069171-8	2013	RESULTS: We successfully generated Tiam1/C1199-CopGFP transgenic mice and induced primary tumors in the intestine of both wild type and Tiam1 transgenic mice by DMH treatment.	1,2-Dimethylhydrazine	161-164	T cell lymphoma invasion and metastasis 1	Mus musculus	136-141
24354449-5	2014	One year after DMH treatment, survival of K-ras(+/-) mice decreased from 88 to 82% compared with wild-type mice.	1,2-Dimethylhydrazine	15-18	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	42-47
24478760-5	2014	GnIH neurons in the PVN or DMH project to the median eminence to control anterior pituitary function via GPR147 expressed in gonadotropes.	1,2-Dimethylhydrazine	27-30	neuropeptide FF receptor 1	Mus musculus	105-111
23712585-0	2013	Calcium inhibits promotion by hot dog of 1,2-dimethylhydrazine-induced mucin-depleted foci in rat colon.	1,2-Dimethylhydrazine	41-62	mucin	Canis lupus familiaris	71-76
22623379-8	2013	An increased expression of Bcl2 while other proteins like Bax, Apaf-1, cyt c, and caspases in the apoptotic pathway, and the tumor suppressor proteins, p53 and p21 get down-regulated after DMH treatment which were reverted back to normal with Celecoxib and Dolastatin 15.	1,2-Dimethylhydrazine	189-192	BCL2, apoptosis regulator	Rattus norvegicus	27-31
22623379-8	2013	An increased expression of Bcl2 while other proteins like Bax, Apaf-1, cyt c, and caspases in the apoptotic pathway, and the tumor suppressor proteins, p53 and p21 get down-regulated after DMH treatment which were reverted back to normal with Celecoxib and Dolastatin 15.	1,2-Dimethylhydrazine	189-192	BCL2 associated X, apoptosis regulator	Rattus norvegicus	58-61
22623379-8	2013	An increased expression of Bcl2 while other proteins like Bax, Apaf-1, cyt c, and caspases in the apoptotic pathway, and the tumor suppressor proteins, p53 and p21 get down-regulated after DMH treatment which were reverted back to normal with Celecoxib and Dolastatin 15.	1,2-Dimethylhydrazine	189-192	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	152-155
22623379-8	2013	An increased expression of Bcl2 while other proteins like Bax, Apaf-1, cyt c, and caspases in the apoptotic pathway, and the tumor suppressor proteins, p53 and p21 get down-regulated after DMH treatment which were reverted back to normal with Celecoxib and Dolastatin 15.	1,2-Dimethylhydrazine	189-192	KRAS proto-oncogene, GTPase	Rattus norvegicus	160-163
23562863-3	2013	We recently found that the orexigenic neuropeptide Y (NPY) in the DMH has specific actions on body adiposity and thermogenesis using a viral-mediated manipulation of NPY in the DMH.	1,2-Dimethylhydrazine	66-69	neuropeptide Y	Homo sapiens	54-57
23562863-3	2013	We recently found that the orexigenic neuropeptide Y (NPY) in the DMH has specific actions on body adiposity and thermogenesis using a viral-mediated manipulation of NPY in the DMH.	1,2-Dimethylhydrazine	66-69	neuropeptide Y	Homo sapiens	166-169
23562863-3	2013	We recently found that the orexigenic neuropeptide Y (NPY) in the DMH has specific actions on body adiposity and thermogenesis using a viral-mediated manipulation of NPY in the DMH.	1,2-Dimethylhydrazine	177-180	neuropeptide Y	Homo sapiens	38-52
23562863-3	2013	We recently found that the orexigenic neuropeptide Y (NPY) in the DMH has specific actions on body adiposity and thermogenesis using a viral-mediated manipulation of NPY in the DMH.	1,2-Dimethylhydrazine	177-180	neuropeptide Y	Homo sapiens	54-57
23562863-3	2013	We recently found that the orexigenic neuropeptide Y (NPY) in the DMH has specific actions on body adiposity and thermogenesis using a viral-mediated manipulation of NPY in the DMH.	1,2-Dimethylhydrazine	177-180	neuropeptide Y	Homo sapiens	166-169
23562863-4	2013	Knockdown of NPY in the DMH promotes the development of brown adipocytes in white adipose tissue and increases brown adipocyte activity.	1,2-Dimethylhydrazine	24-27	neuropeptide Y	Homo sapiens	13-16
23562863-5	2013	DMH NPY knockdown also causes increased thermogenesis and energy expenditure.	1,2-Dimethylhydrazine	0-3	neuropeptide Y	Homo sapiens	4-7
23172177-2	2013	The DMH contains orexigenic neuropeptide Y (NPY) neurons, but the role of these neurons in the control of energy homeostasis is not well understood.	1,2-Dimethylhydrazine	4-7	neuropeptide Y	Rattus norvegicus	28-42
22899565-4	2013	DMH exposure alone produced a high incidence of ACF and showed positive staining for PCNA and AgNORs in colonic tissues.	1,2-Dimethylhydrazine	0-3	proliferating cell nuclear antigen	Rattus norvegicus	85-89
22393105-0	2013	Effect of angiostatin on 1,2-dimethylhydrazine-induced colon cancer in mice.	1,2-Dimethylhydrazine	25-46	plasminogen	Mus musculus	10-21
22393105-13	2013	The administration period of angiostatin corresponds to the precancerous period and the reduction in the number of lesions could be important for the protective function of angiostatin in DMH + angiostain group.	1,2-Dimethylhydrazine	188-191	plasminogen	Mus musculus	29-40
22393105-13	2013	The administration period of angiostatin corresponds to the precancerous period and the reduction in the number of lesions could be important for the protective function of angiostatin in DMH + angiostain group.	1,2-Dimethylhydrazine	188-191	plasminogen	Mus musculus	173-184
23149858-8	2013	As a result, we found that DMH-treated animals were having over-expression of various pro-inflammatory cytokines (IL-1beta, IL-2, and IFNgamma), aberrant nuclear localization of activated cell survival transcription factors (NF-kappaB and Stat3) along with the increased incidence of activated angiogenic factors (MMP-2 and MMP-9) suggesting a marked role of inflammation in the tumor progression.	1,2-Dimethylhydrazine	27-30	interleukin 1 beta	Homo sapiens	114-122
23149858-8	2013	As a result, we found that DMH-treated animals were having over-expression of various pro-inflammatory cytokines (IL-1beta, IL-2, and IFNgamma), aberrant nuclear localization of activated cell survival transcription factors (NF-kappaB and Stat3) along with the increased incidence of activated angiogenic factors (MMP-2 and MMP-9) suggesting a marked role of inflammation in the tumor progression.	1,2-Dimethylhydrazine	27-30	interleukin 2	Homo sapiens	124-128
23149858-8	2013	As a result, we found that DMH-treated animals were having over-expression of various pro-inflammatory cytokines (IL-1beta, IL-2, and IFNgamma), aberrant nuclear localization of activated cell survival transcription factors (NF-kappaB and Stat3) along with the increased incidence of activated angiogenic factors (MMP-2 and MMP-9) suggesting a marked role of inflammation in the tumor progression.	1,2-Dimethylhydrazine	27-30	interferon gamma	Homo sapiens	134-142
23149858-8	2013	As a result, we found that DMH-treated animals were having over-expression of various pro-inflammatory cytokines (IL-1beta, IL-2, and IFNgamma), aberrant nuclear localization of activated cell survival transcription factors (NF-kappaB and Stat3) along with the increased incidence of activated angiogenic factors (MMP-2 and MMP-9) suggesting a marked role of inflammation in the tumor progression.	1,2-Dimethylhydrazine	27-30	signal transducer and activator of transcription 3	Homo sapiens	239-244
23149858-8	2013	As a result, we found that DMH-treated animals were having over-expression of various pro-inflammatory cytokines (IL-1beta, IL-2, and IFNgamma), aberrant nuclear localization of activated cell survival transcription factors (NF-kappaB and Stat3) along with the increased incidence of activated angiogenic factors (MMP-2 and MMP-9) suggesting a marked role of inflammation in the tumor progression.	1,2-Dimethylhydrazine	27-30	matrix metallopeptidase 2	Homo sapiens	314-319
23149858-8	2013	As a result, we found that DMH-treated animals were having over-expression of various pro-inflammatory cytokines (IL-1beta, IL-2, and IFNgamma), aberrant nuclear localization of activated cell survival transcription factors (NF-kappaB and Stat3) along with the increased incidence of activated angiogenic factors (MMP-2 and MMP-9) suggesting a marked role of inflammation in the tumor progression.	1,2-Dimethylhydrazine	27-30	matrix metallopeptidase 9	Homo sapiens	324-329
23197286-1	2013	To investigate the hepatic dihydropyrimidine dehydrogenase (DPD) activity in colorectal cancer (CRC), which is critically important to create a patient-specific dosing regimen, we performed 5-FU pharmacokinetic studies in 1,2-dimethylhydrazine-induced CRC model rats (CRC rats).	1,2-Dimethylhydrazine	222-243	dihydropyrimidine dehydrogenase	Homo sapiens	60-63
23172177-10	2013	The present data suggest that NPY expression in the DMH during chronic hyperphagic conditions plays important roles in feeding behavior and thermogenesis by modulating neuronal functions within the hypothalamus, but not in the brainstem.	1,2-Dimethylhydrazine	52-55	neuropeptide Y	Rattus norvegicus	30-33
23526718-8	2013	While high-fat diet induced hyperphagia, obesity, and hyperinsulinemia, these effects were amplified in rats with DMH NPY overexpression.	1,2-Dimethylhydrazine	114-117	neuropeptide Y	Rattus norvegicus	118-121
23415792-7	2013	The neuropeptide cholecystokinin (CCK) acts in the RVM to enhance nociception and is abundant in the DMH.	1,2-Dimethylhydrazine	101-104	cholecystokinin	Homo sapiens	17-32
23415792-7	2013	The neuropeptide cholecystokinin (CCK) acts in the RVM to enhance nociception and is abundant in the DMH.	1,2-Dimethylhydrazine	101-104	cholecystokinin	Homo sapiens	34-37
23415792-8	2013	Using a retrograde tracer and immunohistochemical labeling, we determined that CCK-expressing neurons in the DMH are the only significant supraspinal source of CCK in the RVM.	1,2-Dimethylhydrazine	109-112	cholecystokinin	Homo sapiens	79-82
23415792-8	2013	Using a retrograde tracer and immunohistochemical labeling, we determined that CCK-expressing neurons in the DMH are the only significant supraspinal source of CCK in the RVM.	1,2-Dimethylhydrazine	109-112	cholecystokinin	Homo sapiens	160-163
23514809-4	2013	In the DMH group, low expression of IL-4, an anti-inflammatory cytokine, was further observed with respect to the other groups.	1,2-Dimethylhydrazine	7-10	interleukin 4	Rattus norvegicus	36-40
23172177-2	2013	The DMH contains orexigenic neuropeptide Y (NPY) neurons, but the role of these neurons in the control of energy homeostasis is not well understood.	1,2-Dimethylhydrazine	4-7	neuropeptide Y	Rattus norvegicus	44-47
23172177-3	2013	NPY expression in the DMH is low under normal conditions in adult rodents but is significantly increased during chronic hyperphagic conditions such as lactation and diet-induced obesity (DIO).	1,2-Dimethylhydrazine	22-25	neuropeptide Y	Rattus norvegicus	0-3
23172177-4	2013	To understand better the role of DMH-NPY neurons, we characterized the efferent projections of DMH-NPY neurons using the anterograde tracer biotinylated dextran amine (BDA) in lactating rats and DIO mice.	1,2-Dimethylhydrazine	33-36	neuropeptide Y	Rattus norvegicus	37-40
23172177-4	2013	To understand better the role of DMH-NPY neurons, we characterized the efferent projections of DMH-NPY neurons using the anterograde tracer biotinylated dextran amine (BDA) in lactating rats and DIO mice.	1,2-Dimethylhydrazine	95-98	neuropeptide Y	Rattus norvegicus	99-102
23172177-9	2013	Furthermore, DMH-NPY projections were not observed within the nucleus of the solitary tract (NTS), another brainstem site critical for the regulation of sympathetic outflow.	1,2-Dimethylhydrazine	13-16	neuropeptide Y	Rattus norvegicus	17-20
23201351-8	2013	However, serotonin-mediated inputs from the NDR to the LC modulate only fear-induced antinociception and not the defensive behaviours evoked by GABA(A) receptor blockade in the DMH.	1,2-Dimethylhydrazine	177-180	serine/threonine kinase 38	Homo sapiens	44-47
23376423-12	2013	After administration of 1,2-dimethylhydrazine and DSS, invasive carcinomas were observed exclusively in Spdef(-/-) mice.	1,2-Dimethylhydrazine	24-45	SAM pointed domain containing ets transcription factor	Mus musculus	104-109
23083763-3	2012	While the actions of ARC NPY in energy balance control have been well studied, a role for DMH NPY is still being unraveled.	1,2-Dimethylhydrazine	90-93	neuropeptide Y	Rattus norvegicus	94-97
23008118-4	2013	In the DMH group treated with green tea, significant reductions in gene overexpressions of colonic nuclear factor kappaB (NF-kappaB), tumour necrosis factor alpha, inducible nitric oxide synthase and cyclooxygenase 2, and NF-kappaB immunostaining indicates the anti-inflammatory effect of green tea in attenuating colon cancer.	1,2-Dimethylhydrazine	7-10	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	200-216
24175821-6	2013	Administration of DMH resulted in significant (p &lt;= 0.05) intestinal and colonic lipid peroxidation (MDA) and reduction of antioxidants such as catalase, glutathione peroxidase, glutathione reductase, glutathione-S- transferase and reduced glutathione.	1,2-Dimethylhydrazine	18-21	glutathione-disulfide reductase	Rattus norvegicus	181-202
24175821-6	2013	Administration of DMH resulted in significant (p &lt;= 0.05) intestinal and colonic lipid peroxidation (MDA) and reduction of antioxidants such as catalase, glutathione peroxidase, glutathione reductase, glutathione-S- transferase and reduced glutathione.	1,2-Dimethylhydrazine	18-21	hematopoietic prostaglandin D synthase	Rattus norvegicus	204-230
24175821-9	2013	In addition, the DMH administered rats showed amplified expression of PCNA in the colon and decreased expression of this proliferative marker was clearly noted with initiation, post-initiation and entire period of ACME treatment regimens.	1,2-Dimethylhydrazine	17-20	proliferating cell nuclear antigen	Rattus norvegicus	70-74
23575271-2	2013	5-FU pharmacokinetic and pharmacodynamic studies were performed using DPD circadian variation in rats with 1,2-dimethylhydrazine-induced CRC.	1,2-Dimethylhydrazine	107-128	dihydropyrimidine dehydrogenase	Rattus norvegicus	70-73
23313404-2	2013	Previously, we have shown that compared to AAVGFP controls, adeno-associated virus (AAV)-mediated overexpression of NPY in the DMH of lean rats resulted in significantly higher body weight gain that was attributed to increased food intake, and this was further exacerbated by a high-fat diet.	1,2-Dimethylhydrazine	127-130	neuropeptide Y	Rattus norvegicus	116-119
24624789-0	2013	[Expression of VEGFA during 1,2-dimethylhydrazine induction of malignant hemangioendothelioma in the renal capsule in mice].	1,2-Dimethylhydrazine	28-49	vascular endothelial growth factor A	Mus musculus	15-20
22982865-0	2012	Short curcumin treatment modulates oxidative stress, arginase activity, aberrant crypt foci, and TGF-beta1 and HES-1 transcripts in 1,2-dimethylhydrazine-colon carcinogenesis in mice.	1,2-Dimethylhydrazine	132-153	hes family bHLH transcription factor 1	Mus musculus	111-116
22982865-5	2012	DMH also increased inducible nitric synthase (iNOS) mRNA transcripts (250%), nitrites level (240%) and arginase activity (296%), leading to nitrosative stress and cell proliferation.	1,2-Dimethylhydrazine	0-3	nitric oxide synthase 2, inducible	Mus musculus	46-50
22361264-2	2012	Neurons that synthesize orexin are also found in the region of the DMH.	1,2-Dimethylhydrazine	67-70	hypocretin neuropeptide precursor	Rattus norvegicus	24-30
23083763-6	2012	The findings of DMH NPY overexpression or induction in animals with increased energy demands and in certain rodent models of obesity implicate a role for DMH NPY in maintaining energy homeostasis.	1,2-Dimethylhydrazine	16-19	neuropeptide Y	Rattus norvegicus	20-23
23083763-6	2012	The findings of DMH NPY overexpression or induction in animals with increased energy demands and in certain rodent models of obesity implicate a role for DMH NPY in maintaining energy homeostasis.	1,2-Dimethylhydrazine	16-19	neuropeptide Y	Rattus norvegicus	158-161
23083763-6	2012	The findings of DMH NPY overexpression or induction in animals with increased energy demands and in certain rodent models of obesity implicate a role for DMH NPY in maintaining energy homeostasis.	1,2-Dimethylhydrazine	154-157	neuropeptide Y	Rattus norvegicus	20-23
23083763-6	2012	The findings of DMH NPY overexpression or induction in animals with increased energy demands and in certain rodent models of obesity implicate a role for DMH NPY in maintaining energy homeostasis.	1,2-Dimethylhydrazine	154-157	neuropeptide Y	Rattus norvegicus	158-161
22326805-4	2012	Mice treated with DMH presented histopathological alterations consistent with tumor development, augmented CD44 expression and increased proteasome peptidase activities.	1,2-Dimethylhydrazine	18-21	CD44 antigen	Mus musculus	107-111
23083763-7	2012	In support of this view, adeno-associated virus (AAV)-mediated overexpression of NPY in the DMH causes increases in food intake and body weight and exacerbates high-fat diet-induced hyperphagia and obesity.	1,2-Dimethylhydrazine	92-95	neuropeptide Y	Rattus norvegicus	81-84
23083763-8	2012	Knockdown of NPY in the DMH via AAV-mediated RNAi ameliorates hyperphagia, obesity and glucose intolerance of Otsuka Long-Evans Tokushima Fatty rats in which DMH NPY overexpression has been proposed to play a causal role.	1,2-Dimethylhydrazine	24-27	neuropeptide Y	Rattus norvegicus	13-16
23083763-8	2012	Knockdown of NPY in the DMH via AAV-mediated RNAi ameliorates hyperphagia, obesity and glucose intolerance of Otsuka Long-Evans Tokushima Fatty rats in which DMH NPY overexpression has been proposed to play a causal role.	1,2-Dimethylhydrazine	158-161	neuropeptide Y	Rattus norvegicus	13-16
23083763-8	2012	Knockdown of NPY in the DMH via AAV-mediated RNAi ameliorates hyperphagia, obesity and glucose intolerance of Otsuka Long-Evans Tokushima Fatty rats in which DMH NPY overexpression has been proposed to play a causal role.	1,2-Dimethylhydrazine	158-161	neuropeptide Y	Rattus norvegicus	162-165
23083763-9	2012	NPY knockdown in the DMH also prevents high-fat diet-induced hyperphagia, obesity and impaired glucose homeostasis.	1,2-Dimethylhydrazine	21-24	neuropeptide Y	Rattus norvegicus	0-3
23083763-10	2012	A detailed examination of actions of DMH NPY reveals that DMH NPY specifically affects nocturnal meal size and produces an inhibitory action on within meal satiety signals.	1,2-Dimethylhydrazine	37-40	neuropeptide Y	Rattus norvegicus	62-65
23083763-11	2012	In addition, DMH NPY modulates energy expenditure likely through affecting brown adipocyte formation and thermogenic activity.	1,2-Dimethylhydrazine	13-16	neuropeptide Y	Rattus norvegicus	17-20
23083763-12	2012	Overall, the recent findings provide clear evidence demonstrating critical roles for DMH NPY in energy balance control, and also imply a potential role for DMH NPY in maintaining glucose homeostasis.	1,2-Dimethylhydrazine	156-159	neuropeptide Y	Rattus norvegicus	160-163
22752389-8	2012	On the other hand, supplementation with selenium to DMH treated rats resulted in a significant decrease in the levels of lipid peroxidation but caused a significant increase in the levels of GSH as well in the activities of GR, GST, SOD, CAT, and GPx.	1,2-Dimethylhydrazine	52-55	glutathione-disulfide reductase	Rattus norvegicus	224-226
22752389-8	2012	On the other hand, supplementation with selenium to DMH treated rats resulted in a significant decrease in the levels of lipid peroxidation but caused a significant increase in the levels of GSH as well in the activities of GR, GST, SOD, CAT, and GPx.	1,2-Dimethylhydrazine	52-55	catalase	Rattus norvegicus	238-241
22561258-0	2012	PTEN regulates apoptotic cell death through PI3-K/Akt/GSK3beta signaling pathway in DMH induced early colon carcinogenesis in rat.	1,2-Dimethylhydrazine	84-87	phosphatase and tensin homolog	Rattus norvegicus	0-4
22561258-0	2012	PTEN regulates apoptotic cell death through PI3-K/Akt/GSK3beta signaling pathway in DMH induced early colon carcinogenesis in rat.	1,2-Dimethylhydrazine	84-87	AKT serine/threonine kinase 1	Rattus norvegicus	50-53
22561258-0	2012	PTEN regulates apoptotic cell death through PI3-K/Akt/GSK3beta signaling pathway in DMH induced early colon carcinogenesis in rat.	1,2-Dimethylhydrazine	84-87	glycogen synthase kinase 3 beta	Rattus norvegicus	54-62
22561258-4	2012	Western blotting and immunofluorescence results indicated that the expression of PI3-K and Akt was promoted in the DMH group while least apoptosis was detected in this group as analyzed by Hoechst 33342-propidium iodide co-staining.	1,2-Dimethylhydrazine	115-118	AKT serine/threonine kinase 1	Rattus norvegicus	91-94
22561258-5	2012	DMH group further detected lower GSK-3beta and PTEN expression as compared to other groups.	1,2-Dimethylhydrazine	0-3	glycogen synthase kinase 3 beta	Rattus norvegicus	33-42
22561258-5	2012	DMH group further detected lower GSK-3beta and PTEN expression as compared to other groups.	1,2-Dimethylhydrazine	0-3	phosphatase and tensin homolog	Rattus norvegicus	47-51
21901745-1	2012	In a genome-wide screen using DMH (differential methylation hybridization) we have identified a CpG island within the 5" region and untranslated first exon of the secretory granule neuroendocrine protein 1 gene (SGNE1/7B2) that showed hypermethylation in low- and high-grade astrocytomas compared to normal brain tissue.	1,2-Dimethylhydrazine	30-33	secretogranin V	Homo sapiens	212-221
22664730-6	2012	To             investigate the role of the PKC isoforms in DMH-induced abnormal HUVEC proliferation,             we modulated PKCmicro expression in DMH-treated HUVECs using small interfering RNA.	1,2-Dimethylhydrazine	149-152	protein kinase D1	Homo sapiens	126-134
22664730-9	2012	Expression of PKCmicro was significant in the DMH-treated group, and downregulation             of PKCmicro inhibited DMH-induced abnormal HUVEC proliferation.	1,2-Dimethylhydrazine	46-49	protein kinase D1	Homo sapiens	14-22
22664730-9	2012	Expression of PKCmicro was significant in the DMH-treated group, and downregulation             of PKCmicro inhibited DMH-induced abnormal HUVEC proliferation.	1,2-Dimethylhydrazine	118-121	protein kinase D1	Homo sapiens	99-107
22664730-10	2012	The PKCmicro isoform is             believed to be important in the abnormal growth of vascular endothelial cells             induced by DMH, and this was confirmed by an objective siRNA experiment, which             showed a clear decrease in PKCmicro expression.	1,2-Dimethylhydrazine	137-140	protein kinase D1	Homo sapiens	4-12
22664730-10	2012	The PKCmicro isoform is             believed to be important in the abnormal growth of vascular endothelial cells             induced by DMH, and this was confirmed by an objective siRNA experiment, which             showed a clear decrease in PKCmicro expression.	1,2-Dimethylhydrazine	137-140	protein kinase D1	Homo sapiens	244-252
22670549-15	2012	CONCLUSION: COX-2 expression was "induced" by DMH and reverted to a "wild"-type level of expression upon exposure to HBO2.	1,2-Dimethylhydrazine	46-49	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	12-17
22439659-4	2012	Subcutaneous injection of DMH (40 mg/kg body weight twice a week for 2 weeks) to the rats resulted in elevated expression of ODC, a genetic marker for CRC, and its transcription factor myelocytomatosis oncogene (c-myc).	1,2-Dimethylhydrazine	26-29	ornithine decarboxylase 1	Rattus norvegicus	125-128
22439659-4	2012	Subcutaneous injection of DMH (40 mg/kg body weight twice a week for 2 weeks) to the rats resulted in elevated expression of ODC, a genetic marker for CRC, and its transcription factor myelocytomatosis oncogene (c-myc).	1,2-Dimethylhydrazine	26-29	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	185-210
22439659-4	2012	Subcutaneous injection of DMH (40 mg/kg body weight twice a week for 2 weeks) to the rats resulted in elevated expression of ODC, a genetic marker for CRC, and its transcription factor myelocytomatosis oncogene (c-myc).	1,2-Dimethylhydrazine	26-29	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	212-217
22439659-5	2012	Furthermore, increased levels of lipid peroxidation and hydroperoxides with diminished levels of antioxidants including superoxide dismutase, catalase, and reduced glutathione were also observed in the tissues of DMH-intoxicated rats.	1,2-Dimethylhydrazine	213-216	catalase	Rattus norvegicus	142-150
22353545-8	2012	Mc3r(-/-) mice displayed a significant reduction in FOS-IR in the DMH during feeding.	1,2-Dimethylhydrazine	66-69	melanocortin 3 receptor	Mus musculus	0-4
22353013-8	2012	beta-Sitosterol also exhibited a protective action against DMH-induced depletion of antioxidants such as catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, glutathione S-transferase, and reduced glutathione in colonic and hepatic tissues of experimental animals.	1,2-Dimethylhydrazine	59-62	catalase	Rattus norvegicus	105-113
22353013-8	2012	beta-Sitosterol also exhibited a protective action against DMH-induced depletion of antioxidants such as catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, glutathione S-transferase, and reduced glutathione in colonic and hepatic tissues of experimental animals.	1,2-Dimethylhydrazine	59-62	hematopoietic prostaglandin D synthase	Rattus norvegicus	184-209
22420317-6	2012	Plasma analysis showed that DMH-exposure induced amplified amounts of interleukin (IL)-4, IL-5, IL-10, and transforming growth factor-beta, whereas MS feeding counteracted this effect but enhanced IL-2, IL12p70, IL21, TNF-alpha, and interferon-gamma.	1,2-Dimethylhydrazine	28-31	interleukin 5	Rattus norvegicus	90-94
22420317-6	2012	Plasma analysis showed that DMH-exposure induced amplified amounts of interleukin (IL)-4, IL-5, IL-10, and transforming growth factor-beta, whereas MS feeding counteracted this effect but enhanced IL-2, IL12p70, IL21, TNF-alpha, and interferon-gamma.	1,2-Dimethylhydrazine	28-31	interleukin 10	Rattus norvegicus	96-101
22420317-6	2012	Plasma analysis showed that DMH-exposure induced amplified amounts of interleukin (IL)-4, IL-5, IL-10, and transforming growth factor-beta, whereas MS feeding counteracted this effect but enhanced IL-2, IL12p70, IL21, TNF-alpha, and interferon-gamma.	1,2-Dimethylhydrazine	28-31	interleukin 2	Rattus norvegicus	197-201
22420317-6	2012	Plasma analysis showed that DMH-exposure induced amplified amounts of interleukin (IL)-4, IL-5, IL-10, and transforming growth factor-beta, whereas MS feeding counteracted this effect but enhanced IL-2, IL12p70, IL21, TNF-alpha, and interferon-gamma.	1,2-Dimethylhydrazine	28-31	interleukin 21	Rattus norvegicus	212-216
22420317-6	2012	Plasma analysis showed that DMH-exposure induced amplified amounts of interleukin (IL)-4, IL-5, IL-10, and transforming growth factor-beta, whereas MS feeding counteracted this effect but enhanced IL-2, IL12p70, IL21, TNF-alpha, and interferon-gamma.	1,2-Dimethylhydrazine	28-31	tumor necrosis factor	Rattus norvegicus	218-227
22420317-6	2012	Plasma analysis showed that DMH-exposure induced amplified amounts of interleukin (IL)-4, IL-5, IL-10, and transforming growth factor-beta, whereas MS feeding counteracted this effect but enhanced IL-2, IL12p70, IL21, TNF-alpha, and interferon-gamma.	1,2-Dimethylhydrazine	28-31	interferon gamma	Rattus norvegicus	233-249
22441428-6	2012	Inflammation remains the dominant molecular mechanism in the development of multiple plaque lesions, the carcinogenic lesions in a DMH-induced process that may be mediated by COX-2.	1,2-Dimethylhydrazine	131-134	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	175-180
22441428-7	2012	Western blot and immunofluorescence analysis revealed a higher expression of COX-2 and nuclear factor-kappaB, the transcription factors responsible for proinflammatory proteins such as TNFalpha, and also the inducible nitric oxide synthase in the DMH group, which was further recovered significantly with the use of Celecoxib and Dolastatin.	1,2-Dimethylhydrazine	247-250	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	77-82
21871472-2	2012	Administration of CCK into the DMH reduces food intake and OLETF rats lacking CCK1 receptors (CCK1R) become hyperphagic and obese.	1,2-Dimethylhydrazine	31-34	cholecystokinin	Rattus norvegicus	18-21
22128027-2	2012	Here, we show that acute stress increases 7alpha-OH PREG synthesis in the dorsomedial hypothalamus (DMH) through corticosterone (CORT) action in newts.	1,2-Dimethylhydrazine	100-103	cortistatin	Homo sapiens	129-133
22128027-6	2012	Glucocorticoid receptor was present in DMH neurons expressing CYP7B.	1,2-Dimethylhydrazine	39-42	nuclear receptor subfamily 3 group C member 1	Homo sapiens	0-23
22128027-7	2012	Thus, CORT appears to act directly on DMH neurons to increase 7alpha-OH PREG synthesis.	1,2-Dimethylhydrazine	38-41	cortistatin	Homo sapiens	6-10
22128027-11	2012	These results indicate that acute stress increases the synthesis of 7alpha-OH PREG via CORT action in the DMH, and 7alpha-OH PREG activates serotonergic neurons in the DMH that may coordinate behavioral responses to stress.	1,2-Dimethylhydrazine	106-109	cortistatin	Homo sapiens	87-91
21505005-0	2012	Effect of endostatin on 1,2-dimethylhydrazine-induced colon tumor in mice.	1,2-Dimethylhydrazine	24-45	collagen, type XVIII, alpha 1	Mus musculus	10-20
21505005-2	2012	We aimed to investigate the in vivo activities of low dose of recombinant human endostatin on 1,2-dimethylhydrazine (DMH)-induced mice colon cancer.	1,2-Dimethylhydrazine	94-115	collagen, type XVIII, alpha 1	Mus musculus	80-90
21505005-2	2012	We aimed to investigate the in vivo activities of low dose of recombinant human endostatin on 1,2-dimethylhydrazine (DMH)-induced mice colon cancer.	1,2-Dimethylhydrazine	117-120	collagen, type XVIII, alpha 1	Mus musculus	80-90
21505005-9	2012	At the end of our study, we noticed that the number of lesions decreased by 25% in the group of endostatin, considering the number of the lesions in the group of DMH.	1,2-Dimethylhydrazine	162-165	collagen, type XVIII, alpha 1	Mus musculus	96-106
21871472-5	2012	OLETF rats with AAVCCK1R injections demonstrated a 65% replenishment of Cck1r mRNA expression in the DMH relative to lean LETO control rats.	1,2-Dimethylhydrazine	101-104	cholecystokinin A receptor	Rattus norvegicus	72-77
21871472-7	2012	Importantly, the elevation in blood glucose level of OLETF rats was attenuated by the AAVCCK1R injections (p=0.03), suggesting a role for DMH CCK signaling in glucose homeostasis.	1,2-Dimethylhydrazine	138-141	cholecystokinin	Rattus norvegicus	89-92
21871472-8	2012	In support of this role, administration of CCK into the DMH of intact rats enhanced glucose tolerance, as this occurred through activation of CCK1R but not CCK2R signaling.	1,2-Dimethylhydrazine	56-59	cholecystokinin	Rattus norvegicus	43-46
21871472-9	2012	In conclusion, partial replenishment of CCK1R in the DMH of OLETF rats, although insufficient for altering overall food intake and body weight, normalizes meal pattern changes and reduces blood glucose levels.	1,2-Dimethylhydrazine	53-56	cholecystokinin A receptor	Rattus norvegicus	40-45
21871472-10	2012	Our study also shows a novel role of DMH CCK signaling in glucose homeostasis.	1,2-Dimethylhydrazine	37-40	cholecystokinin	Rattus norvegicus	41-44
23167349-7	2012	TA treatment prevented deteriorative effects induced by DMH through a protective mechanism that involved reduction of oxidative stress as well as COX-2, i-NOS, PCNA protein expression levels and TNF-alpha(p&lt;0.001) release.	1,2-Dimethylhydrazine	56-59	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	146-151
21871472-3	2012	We hypothesized that site specific replenishment of CCK1R in the DMH of OLETF rats would attenuate aspects of their feeding deficits.	1,2-Dimethylhydrazine	65-68	cholecystokinin A receptor	Rattus norvegicus	52-57
21871472-4	2012	Recombinant vectors of adeno-associated viral (AAV)-mediated expression of CCK1R (AAVCCK1R) were bilaterally delivered into the DMH of OLETF.	1,2-Dimethylhydrazine	128-131	cholecystokinin A receptor	Rattus norvegicus	75-80
22519408-8	2012	In both phases, DMH treatment showed an increase in pan Ras, Raf, MEK1/2, extracellular signal regulated kinase (Erk)1/2, and c-fos levels.	1,2-Dimethylhydrazine	16-19	MEK homolog 1	Zea mays	66-72
22919283-13	2012	The expressions of anti-apoptotic gene, Survivin, and cell cycle progression-associated gene, Cyclin D1, were increased by DMH-treatment.	1,2-Dimethylhydrazine	123-126	cyclin D1	Rattus norvegicus	94-103
22919283-15	2012	The expressions of all SIRT1-7 mRNAs were significantly increased by CR in DMH-treated rats.	1,2-Dimethylhydrazine	75-78	sirtuin 1	Rattus norvegicus	23-28
22519408-10	2012	Treatment with FO + CO (1:1) + DMH decreased pan Ras, MEK1/2 and Erk1/2 levels in post-initiation phase whereas Raf and c-fos were decreased in both phases.	1,2-Dimethylhydrazine	31-34	MEK homolog 1	Zea mays	54-60
22519408-11	2012	Treatment with FO + CO (2.5:1) + DMH decreased Ras, Raf, MEK1/2, Erk1/2, and c-fos levels in both phases.	1,2-Dimethylhydrazine	33-36	MEK homolog 1	Zea mays	57-63
22848295-0	2011	Consumption of vitamin B6 reduces colonic damage and protein expression of HSP70 and HO-1, the anti-tumor targets, in rats exposed to 1,2-dimethylhydrazine.	1,2-Dimethylhydrazine	134-155	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	75-80
22034979-6	2011	We found a strong correlation between the expression of food anticipation measured by running-wheel activity and Fos expression levels in the DMH of ABA-normal rats, whereas no correlation was found in ABA-random rats.	1,2-Dimethylhydrazine	142-145	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	113-116
22848295-0	2011	Consumption of vitamin B6 reduces colonic damage and protein expression of HSP70 and HO-1, the anti-tumor targets, in rats exposed to 1,2-dimethylhydrazine.	1,2-Dimethylhydrazine	134-155	heme oxygenase 1	Rattus norvegicus	85-89
22848295-7	2011	This study provided evidence that dietary supplemental vitamin B6 suppresses colon damage, epithelial cell proliferation and protein expression of HSP70 and HO-1, the targets for anti-tumor agents, in rats exposed to DMH.	1,2-Dimethylhydrazine	217-220	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	147-152
22848295-7	2011	This study provided evidence that dietary supplemental vitamin B6 suppresses colon damage, epithelial cell proliferation and protein expression of HSP70 and HO-1, the targets for anti-tumor agents, in rats exposed to DMH.	1,2-Dimethylhydrazine	217-220	heme oxygenase 1	Rattus norvegicus	157-161
21761111-0	2011	Expression of NHERF1 in colonic tumors induced by 1,2-dimethylhydrazine in rats is independent of plasma ovarian steroids.	1,2-Dimethylhydrazine	50-71	SLC9A3 regulator 1	Rattus norvegicus	14-20
21803737-7	2011	In the mutation assays, DMH plus DSS enhanced the gpt mutant frequency (MF) in the colon, and the silymarin treatments reduced the MFs by 20%.	1,2-Dimethylhydrazine	24-27	glutamic--pyruvic transaminase	Rattus norvegicus	50-53
22866128-6	2011	In conclusion, the present study showed that PSK not only suppressed colorectal tumor formation in the DMH+DSS-induced IBD model, but also improved the survival rate, indicating that anti-inflammatory activity is one of the mechanisms for the antitumor effects of PSK.	1,2-Dimethylhydrazine	103-106	TAO kinase 2	Mus musculus	45-48
21865462-8	2011	We demonstrated that neurons in the dorsomedial hypothalamus (DMH) of DIO mice mediate the thermogenic responses to hyperleptinemia in obese mammals because blockade of leptin receptors in the DMH prevented the thermogenic effects of leptin.	1,2-Dimethylhydrazine	62-65	leptin	Mus musculus	121-127
21865462-8	2011	We demonstrated that neurons in the dorsomedial hypothalamus (DMH) of DIO mice mediate the thermogenic responses to hyperleptinemia in obese mammals because blockade of leptin receptors in the DMH prevented the thermogenic effects of leptin.	1,2-Dimethylhydrazine	62-65	leptin	Mus musculus	169-175
21865462-8	2011	We demonstrated that neurons in the dorsomedial hypothalamus (DMH) of DIO mice mediate the thermogenic responses to hyperleptinemia in obese mammals because blockade of leptin receptors in the DMH prevented the thermogenic effects of leptin.	1,2-Dimethylhydrazine	193-196	leptin	Mus musculus	121-127
21865462-8	2011	We demonstrated that neurons in the dorsomedial hypothalamus (DMH) of DIO mice mediate the thermogenic responses to hyperleptinemia in obese mammals because blockade of leptin receptors in the DMH prevented the thermogenic effects of leptin.	1,2-Dimethylhydrazine	193-196	leptin	Mus musculus	169-175
21865462-9	2011	Peripheral Melotan II (MTII) injection increased iBAT temperature, but it was blunted by blockade of DMH melanocortin receptors (MC4Rs) by injecting agouti-related peptide (AgRP) directly into the DMH, suggesting a physiological role of the DMH on temperature regulation in animals with normal body weight.	1,2-Dimethylhydrazine	101-104	agouti related neuropeptide	Mus musculus	149-171
21865462-9	2011	Peripheral Melotan II (MTII) injection increased iBAT temperature, but it was blunted by blockade of DMH melanocortin receptors (MC4Rs) by injecting agouti-related peptide (AgRP) directly into the DMH, suggesting a physiological role of the DMH on temperature regulation in animals with normal body weight.	1,2-Dimethylhydrazine	101-104	agouti related neuropeptide	Mus musculus	173-177
21865462-9	2011	Peripheral Melotan II (MTII) injection increased iBAT temperature, but it was blunted by blockade of DMH melanocortin receptors (MC4Rs) by injecting agouti-related peptide (AgRP) directly into the DMH, suggesting a physiological role of the DMH on temperature regulation in animals with normal body weight.	1,2-Dimethylhydrazine	197-200	agouti related neuropeptide	Mus musculus	149-171
21865462-9	2011	Peripheral Melotan II (MTII) injection increased iBAT temperature, but it was blunted by blockade of DMH melanocortin receptors (MC4Rs) by injecting agouti-related peptide (AgRP) directly into the DMH, suggesting a physiological role of the DMH on temperature regulation in animals with normal body weight.	1,2-Dimethylhydrazine	197-200	agouti related neuropeptide	Mus musculus	173-177
22321754-1	2011	OBJECTIVE: To explore the effects and relationship of specific demethylation agent 5-Aza-2"-deoxycytidine (5-Aza-CdR) on colorectal cancer (CRC) induced by 1, 2-dimethylhydrazine (DMH) in mouse and the in vivo expression of cyclin-dependent kinases inhibitor p16/CDKN(2) mRNA.	1,2-Dimethylhydrazine	156-178	cyclin dependent kinase inhibitor 2A	Mus musculus	259-262
22321754-9	2011	Immunohistochemical staining showed there was a significant elevation of PCNA in the group DMH (16/19) as compared with that in the group DMH + 5-Aza-CdR (11/19, P &lt; 0.05).	1,2-Dimethylhydrazine	91-94	proliferating cell nuclear antigen	Mus musculus	73-77
22321754-10	2011	In situ hybridization revealed that the level of tumor suppressor gene p16/CDKN(2) mRNA was significantly lower in the group DMH than that in the group DMH + 5-Aza-CdR.	1,2-Dimethylhydrazine	125-128	cyclin dependent kinase inhibitor 2A	Mus musculus	71-74
22321754-10	2011	In situ hybridization revealed that the level of tumor suppressor gene p16/CDKN(2) mRNA was significantly lower in the group DMH than that in the group DMH + 5-Aza-CdR.	1,2-Dimethylhydrazine	152-155	cyclin dependent kinase inhibitor 2A	Mus musculus	71-74
21761111-3	2011	We studied the expression and localization of NHERF1 and beta-catenin by immunohistochemistry in colonic tumors induced by 1,2 dimethylhidrazine (DMH) in Sprague-Dawley rats.	1,2-Dimethylhydrazine	146-149	SLC9A3 regulator 1	Rattus norvegicus	46-52
21463623-7	2011	DMH-induced rats exhibited elevated expressions of PI3K and Akt as confirmed by immunofluorescence, immunoblot and confocal microscopic analysis.	1,2-Dimethylhydrazine	0-3	AKT serine/threonine kinase 1	Rattus norvegicus	60-63
22754195-3	2011	The DMH administration invariably led to increase in the liver microsomal proteins of molecular weight of about 29 (ERp29) and 53 kDa (ERp53) and decrease in the protein of molecular weight of 36 kDa (ERp36) thereby suggesting the interference of DMH and its metabolites with normal protein biosynthesis and folding, in the reticular membranes of the liver cells thus developing ER stress.	1,2-Dimethylhydrazine	4-7	endoplasmic reticulum protein 29	Mus musculus	116-121
22754195-7	2011	It simultaneously increased the level of reduced glutathione (GSH) and the activity of glutathione-S-transferase (GST) thereby suggesting that it prevents peroxidative damage and also diverts the active metabolites (electrophiles) of DMH from their interactions with critical cellular bio-molecules which could be responsible for its protective action against DMH.	1,2-Dimethylhydrazine	234-237	hematopoietic prostaglandin D synthase	Mus musculus	87-112
22754195-7	2011	It simultaneously increased the level of reduced glutathione (GSH) and the activity of glutathione-S-transferase (GST) thereby suggesting that it prevents peroxidative damage and also diverts the active metabolites (electrophiles) of DMH from their interactions with critical cellular bio-molecules which could be responsible for its protective action against DMH.	1,2-Dimethylhydrazine	234-237	hematopoietic prostaglandin D synthase	Mus musculus	114-117
22754195-7	2011	It simultaneously increased the level of reduced glutathione (GSH) and the activity of glutathione-S-transferase (GST) thereby suggesting that it prevents peroxidative damage and also diverts the active metabolites (electrophiles) of DMH from their interactions with critical cellular bio-molecules which could be responsible for its protective action against DMH.	1,2-Dimethylhydrazine	360-363	hematopoietic prostaglandin D synthase	Mus musculus	87-112
22754195-7	2011	It simultaneously increased the level of reduced glutathione (GSH) and the activity of glutathione-S-transferase (GST) thereby suggesting that it prevents peroxidative damage and also diverts the active metabolites (electrophiles) of DMH from their interactions with critical cellular bio-molecules which could be responsible for its protective action against DMH.	1,2-Dimethylhydrazine	360-363	hematopoietic prostaglandin D synthase	Mus musculus	114-117
21463623-0	2011	Ellagic acid prevents rat colon carcinogenesis induced by 1, 2 dimethyl hydrazine through inhibition of AKT-phosphoinositide-3 kinase pathway.	1,2-Dimethylhydrazine	58-81	AKT serine/threonine kinase 1	Rattus norvegicus	104-107
21463623-11	2011	This study reveals the involvement of PI3K-Akt signaling through which ellagic acid induces apoptosis and subsequently suppresses colon cancer during DMH-induced rat colon carcinogenesis.	1,2-Dimethylhydrazine	150-153	AKT serine/threonine kinase 1	Rattus norvegicus	43-46
21289197-6	2011	Using the retrograde, transsynaptic tracer pseudorabies virus (PRV) injected into the BAT of mice, we identified PRV-labeled LepRb neurons in the DMH/DHA and mPOA (and other sites), thus indicating their involvement in the regulation of sympathetic BAT circuits.	1,2-Dimethylhydrazine	146-149	leptin receptor	Mus musculus	125-130
21531339-2	2011	Here we report that knockdown of NPY expression in the DMH by adeno-associated virus-mediated RNAi reduced fat depots in rats fed regular chow and ameliorated high-fat diet-induced hyperphagia and obesity.	1,2-Dimethylhydrazine	55-58	neuropeptide Y	Rattus norvegicus	33-36
21531339-3	2011	DMH NPY knockdown resulted in development of brown adipocytes in inguinal white adipose tissue through the sympathetic nervous system.	1,2-Dimethylhydrazine	0-3	neuropeptide Y	Rattus norvegicus	4-7
21289197-7	2011	Indeed, acute cold exposure induced c-Fos (as a surrogate for neuronal activity) in DMH/DHA LepRb neurons, and a large number of mPOA LepRb neurons project to the DMH/DHA.	1,2-Dimethylhydrazine	84-87	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	36-41
21679035-0	2011	Reduced tumour progression and angiogenesis in 1,2-dimethylhydrazine mice treated with NS-398 is associated with down-regulation of cyclooxygenase-2 and decreased beta-catenin nuclear localisation.	1,2-Dimethylhydrazine	47-68	prostaglandin-endoperoxide synthase 2	Mus musculus	132-148
21679035-0	2011	Reduced tumour progression and angiogenesis in 1,2-dimethylhydrazine mice treated with NS-398 is associated with down-regulation of cyclooxygenase-2 and decreased beta-catenin nuclear localisation.	1,2-Dimethylhydrazine	47-68	catenin (cadherin associated protein), beta 1	Mus musculus	163-175
21679035-3	2011	The aim of this study was to elucidate the effects of NS-398 in the 1,2-dimethylhydrazine (DMH) mouse model with respect to alteration in the expression of COX-2 and E-cadherin-catenin complex.	1,2-Dimethylhydrazine	68-89	cytochrome c oxidase II, mitochondrial	Mus musculus	156-161
21679035-3	2011	The aim of this study was to elucidate the effects of NS-398 in the 1,2-dimethylhydrazine (DMH) mouse model with respect to alteration in the expression of COX-2 and E-cadherin-catenin complex.	1,2-Dimethylhydrazine	68-89	cadherin 1	Mus musculus	166-176
21679035-3	2011	The aim of this study was to elucidate the effects of NS-398 in the 1,2-dimethylhydrazine (DMH) mouse model with respect to alteration in the expression of COX-2 and E-cadherin-catenin complex.	1,2-Dimethylhydrazine	91-94	cytochrome c oxidase II, mitochondrial	Mus musculus	156-161
21679035-3	2011	The aim of this study was to elucidate the effects of NS-398 in the 1,2-dimethylhydrazine (DMH) mouse model with respect to alteration in the expression of COX-2 and E-cadherin-catenin complex.	1,2-Dimethylhydrazine	91-94	cadherin 1	Mus musculus	166-176
21171084-6	2011	In the adenomas from DMH-treated K-ras{Val12} mice, K-ras{Val12} transgene recombination and expression were confirmed, with immunohistochemical evidence of strong Erk/MapK and mild PI3K/Akt pathway activation compared with adenomas from DMH-treated wild-type mice.	1,2-Dimethylhydrazine	21-24	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	33-38
21171084-6	2011	In the adenomas from DMH-treated K-ras{Val12} mice, K-ras{Val12} transgene recombination and expression were confirmed, with immunohistochemical evidence of strong Erk/MapK and mild PI3K/Akt pathway activation compared with adenomas from DMH-treated wild-type mice.	1,2-Dimethylhydrazine	21-24	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	52-57
21171084-6	2011	In the adenomas from DMH-treated K-ras{Val12} mice, K-ras{Val12} transgene recombination and expression were confirmed, with immunohistochemical evidence of strong Erk/MapK and mild PI3K/Akt pathway activation compared with adenomas from DMH-treated wild-type mice.	1,2-Dimethylhydrazine	21-24	mitogen-activated protein kinase 1	Mus musculus	164-167
21171084-6	2011	In the adenomas from DMH-treated K-ras{Val12} mice, K-ras{Val12} transgene recombination and expression were confirmed, with immunohistochemical evidence of strong Erk/MapK and mild PI3K/Akt pathway activation compared with adenomas from DMH-treated wild-type mice.	1,2-Dimethylhydrazine	21-24	thymoma viral proto-oncogene 1	Mus musculus	187-190
21171084-7	2011	Microarray hybridization and clustering analysis demonstrated different expression profiles in adenomas from DMH-treated wild-type and DMH-treated K-ras{Val12} mice, indicating involvement of different molecular mechanisms including Erk/MapK and PI3K/Akt signalling in K-ras{Val12}-expressing adenomas.	1,2-Dimethylhydrazine	109-112	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	147-152
21171084-7	2011	Microarray hybridization and clustering analysis demonstrated different expression profiles in adenomas from DMH-treated wild-type and DMH-treated K-ras{Val12} mice, indicating involvement of different molecular mechanisms including Erk/MapK and PI3K/Akt signalling in K-ras{Val12}-expressing adenomas.	1,2-Dimethylhydrazine	109-112	mitogen-activated protein kinase 1	Mus musculus	233-236
21171084-7	2011	Microarray hybridization and clustering analysis demonstrated different expression profiles in adenomas from DMH-treated wild-type and DMH-treated K-ras{Val12} mice, indicating involvement of different molecular mechanisms including Erk/MapK and PI3K/Akt signalling in K-ras{Val12}-expressing adenomas.	1,2-Dimethylhydrazine	109-112	thymoma viral proto-oncogene 1	Mus musculus	251-254
21171084-7	2011	Microarray hybridization and clustering analysis demonstrated different expression profiles in adenomas from DMH-treated wild-type and DMH-treated K-ras{Val12} mice, indicating involvement of different molecular mechanisms including Erk/MapK and PI3K/Akt signalling in K-ras{Val12}-expressing adenomas.	1,2-Dimethylhydrazine	109-112	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	269-274
21171084-7	2011	Microarray hybridization and clustering analysis demonstrated different expression profiles in adenomas from DMH-treated wild-type and DMH-treated K-ras{Val12} mice, indicating involvement of different molecular mechanisms including Erk/MapK and PI3K/Akt signalling in K-ras{Val12}-expressing adenomas.	1,2-Dimethylhydrazine	135-138	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	147-152
21171084-7	2011	Microarray hybridization and clustering analysis demonstrated different expression profiles in adenomas from DMH-treated wild-type and DMH-treated K-ras{Val12} mice, indicating involvement of different molecular mechanisms including Erk/MapK and PI3K/Akt signalling in K-ras{Val12}-expressing adenomas.	1,2-Dimethylhydrazine	135-138	mitogen-activated protein kinase 1	Mus musculus	233-236
21171084-7	2011	Microarray hybridization and clustering analysis demonstrated different expression profiles in adenomas from DMH-treated wild-type and DMH-treated K-ras{Val12} mice, indicating involvement of different molecular mechanisms including Erk/MapK and PI3K/Akt signalling in K-ras{Val12}-expressing adenomas.	1,2-Dimethylhydrazine	135-138	thymoma viral proto-oncogene 1	Mus musculus	251-254
21171084-7	2011	Microarray hybridization and clustering analysis demonstrated different expression profiles in adenomas from DMH-treated wild-type and DMH-treated K-ras{Val12} mice, indicating involvement of different molecular mechanisms including Erk/MapK and PI3K/Akt signalling in K-ras{Val12}-expressing adenomas.	1,2-Dimethylhydrazine	135-138	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	269-274
21171084-8	2011	Array-comparative genomic hybridization analysis showed chromosome stability in both cohorts, with only a very few tiny alterations observed in one adenoma from a DMH-treated K-ras{Val12} mouse.	1,2-Dimethylhydrazine	163-166	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	175-180
21171084-9	2011	Taken together, these data show that mutant K-ras significantly promotes DMH-induced colorectal tumourigenesis, resulting in distinct changes in cell signalling and proliferation, but does not alter chromosome stability in the tumours.	1,2-Dimethylhydrazine	73-76	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	44-49
22296388-10	2011	PCNA-labeled indexes (PCNA-LI) in the DMH-initiated colonic mucosa were found to be decreased by both doses of flaxseeds administration.	1,2-Dimethylhydrazine	38-41	proliferating cell nuclear antigen	Rattus norvegicus	0-4
22296388-10	2011	PCNA-labeled indexes (PCNA-LI) in the DMH-initiated colonic mucosa were found to be decreased by both doses of flaxseeds administration.	1,2-Dimethylhydrazine	38-41	proliferating cell nuclear antigen	Rattus norvegicus	22-26
21289197-9	2011	Thus, these data present strong evidence that LepRb neurons in the DMH/DHA and mPOA mediate thermoregulatory leptin action.	1,2-Dimethylhydrazine	67-70	leptin receptor	Mus musculus	46-51
21289197-9	2011	Thus, these data present strong evidence that LepRb neurons in the DMH/DHA and mPOA mediate thermoregulatory leptin action.	1,2-Dimethylhydrazine	67-70	leptin	Homo sapiens	109-115
21289197-7	2011	Indeed, acute cold exposure induced c-Fos (as a surrogate for neuronal activity) in DMH/DHA LepRb neurons, and a large number of mPOA LepRb neurons project to the DMH/DHA.	1,2-Dimethylhydrazine	163-166	leptin receptor	Mus musculus	134-139
21289197-8	2011	Furthermore, DMH/DHA LepRb neurons (and a subpopulation of LepRb mPOA neurons) project and synaptically couple to rostral raphe pallidus neurons, consistent with the current understanding of BAT thermoregulatory circuits from the DMH/DHA and mPOA (Dimicco and Zaretsky, 2007; Morrison et al., 2008).	1,2-Dimethylhydrazine	13-16	leptin receptor	Mus musculus	21-26
21967455-5	2011	DMH treatment caused a significant decrease in the activities of disaccharidases (sucrase, lactase, and maltase), but a significant increase in the activity of alkaline phosphatase.	1,2-Dimethylhydrazine	0-3	lactase	Rattus norvegicus	91-98
21963975-0	2011	[Chemopreventive effects of 5-fluorouracil and lactoferrin on goldfish intestinal carcinogenesis induced by 1,2-dimethylhydrazine].	1,2-Dimethylhydrazine	108-129	lactotransferrin	Bos taurus	47-58
21857934-7	2011	Microarray gene expression analysis showed that S100a9, Defa20, Mmp10, Mmp7, Ptgs2, and Ang2 were among the most downregulated genes, whereas Per3, Tef, Rnf152, and Prdx6 were significantly upregulated in the DMH + Calcium group compared with the DMH group.	1,2-Dimethylhydrazine	209-212	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	48-54
21857934-7	2011	Microarray gene expression analysis showed that S100a9, Defa20, Mmp10, Mmp7, Ptgs2, and Ang2 were among the most downregulated genes, whereas Per3, Tef, Rnf152, and Prdx6 were significantly upregulated in the DMH + Calcium group compared with the DMH group.	1,2-Dimethylhydrazine	247-250	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	48-54
20617408-5	2010	1,2-dimethylhydrazine (DMH) was used for experimental colon cancer model in rat and diclofenac as the preferential COX-2 selective chemopreventive agent.	1,2-Dimethylhydrazine	0-21	prostaglandin-endoperoxide synthase 2	Homo sapiens	115-120
20617408-8	2010	COX-2 mRNA expression as well as PGE2 levels was elevated after DMH treatment; however, COX-1 mRNA expression was unaltered as seen by reverse transcriptase-polymerase chain reaction (RT-PCR) analysis.	1,2-Dimethylhydrazine	64-67	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-5
20617408-9	2010	DMH also activated PI3-kinase, Akt, Wnt, and beta-catenin expressions but reduced the glycogen synthase kinase-3beta (GSK-3beta) levels.	1,2-Dimethylhydrazine	0-3	AKT serine/threonine kinase 1	Homo sapiens	31-34
20617408-9	2010	DMH also activated PI3-kinase, Akt, Wnt, and beta-catenin expressions but reduced the glycogen synthase kinase-3beta (GSK-3beta) levels.	1,2-Dimethylhydrazine	0-3	Wnt family member 2	Rattus norvegicus	36-39
20617408-9	2010	DMH also activated PI3-kinase, Akt, Wnt, and beta-catenin expressions but reduced the glycogen synthase kinase-3beta (GSK-3beta) levels.	1,2-Dimethylhydrazine	0-3	catenin beta 1	Homo sapiens	45-57
20617408-9	2010	DMH also activated PI3-kinase, Akt, Wnt, and beta-catenin expressions but reduced the glycogen synthase kinase-3beta (GSK-3beta) levels.	1,2-Dimethylhydrazine	0-3	glycogen synthase kinase 3 beta	Homo sapiens	86-116
20617408-9	2010	DMH also activated PI3-kinase, Akt, Wnt, and beta-catenin expressions but reduced the glycogen synthase kinase-3beta (GSK-3beta) levels.	1,2-Dimethylhydrazine	0-3	glycogen synthase kinase 3 beta	Homo sapiens	118-127
20617408-10	2010	Co-administration of diclofenac with DMH increased the mRNA expression of GSK-3beta while inactivating PI3-kinase, Akt, Wnt, and beta-catenin.	1,2-Dimethylhydrazine	37-40	glycogen synthase kinase 3 beta	Homo sapiens	74-83
20617408-10	2010	Co-administration of diclofenac with DMH increased the mRNA expression of GSK-3beta while inactivating PI3-kinase, Akt, Wnt, and beta-catenin.	1,2-Dimethylhydrazine	37-40	AKT serine/threonine kinase 1	Homo sapiens	115-118
20617408-10	2010	Co-administration of diclofenac with DMH increased the mRNA expression of GSK-3beta while inactivating PI3-kinase, Akt, Wnt, and beta-catenin.	1,2-Dimethylhydrazine	37-40	Wnt family member 2	Rattus norvegicus	120-123
20617408-10	2010	Co-administration of diclofenac with DMH increased the mRNA expression of GSK-3beta while inactivating PI3-kinase, Akt, Wnt, and beta-catenin.	1,2-Dimethylhydrazine	37-40	catenin beta 1	Homo sapiens	129-141
20381503-9	2010	However, RFRP neuronal numbers in the DMH and fiber projections to the POA were significantly increased after chronic citalopram treatment, which suggests citalopram induced inhibition of sexual behavior involves the modulation of RFRP through serotonin receptors in the DMH.	1,2-Dimethylhydrazine	38-41	neuropeptide VF precursor	Mus musculus	9-13
20406206-8	2010	Nuclear factor-kappa B (NF-kappaB) actively involved in the regulation of both pro-inflammatory proteins [inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2)] and pro-inflammatory cytokines [tumour necrosis factor (TNF)-alpha and interleukin (IL)-6] and in our study 1,2-dimethylhydrazine-induced group exhibited elevated expressions of all these inflammatory proteins.	1,2-Dimethylhydrazine	283-304	nitric oxide synthase 2	Rattus norvegicus	106-137
20406206-8	2010	Nuclear factor-kappa B (NF-kappaB) actively involved in the regulation of both pro-inflammatory proteins [inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2)] and pro-inflammatory cytokines [tumour necrosis factor (TNF)-alpha and interleukin (IL)-6] and in our study 1,2-dimethylhydrazine-induced group exhibited elevated expressions of all these inflammatory proteins.	1,2-Dimethylhydrazine	283-304	tumor necrosis factor	Rattus norvegicus	207-241
20406206-8	2010	Nuclear factor-kappa B (NF-kappaB) actively involved in the regulation of both pro-inflammatory proteins [inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2)] and pro-inflammatory cytokines [tumour necrosis factor (TNF)-alpha and interleukin (IL)-6] and in our study 1,2-dimethylhydrazine-induced group exhibited elevated expressions of all these inflammatory proteins.	1,2-Dimethylhydrazine	283-304	interleukin 6	Rattus norvegicus	246-264
20440209-8	2010	DMH treatment reduced the expression of Bax and cytochrome C whereas etoricoxib promoted the expression of the same.	1,2-Dimethylhydrazine	0-3	BCL2 associated X, apoptosis regulator	Rattus norvegicus	40-43
20440209-9	2010	Protein expression of antiapoptotic protein Bcl-2 was also studied in colonic mucosa and was found high in the DMH-treated group and low in DMH+etoricoxib treated animals.	1,2-Dimethylhydrazine	111-114	BCL2, apoptosis regulator	Rattus norvegicus	44-49
20440209-9	2010	Protein expression of antiapoptotic protein Bcl-2 was also studied in colonic mucosa and was found high in the DMH-treated group and low in DMH+etoricoxib treated animals.	1,2-Dimethylhydrazine	140-143	BCL2, apoptosis regulator	Rattus norvegicus	44-49
20720296-4	2010	In this work we study the physical properties and the spin-polarization effects of p-type DMH based in group-IV semiconductors (Si, Ge, SiGe, and SiC), by performing self-consistent [Formula: see text] calculations in the local spin density approximation.	1,2-Dimethylhydrazine	90-93	spindlin 1	Homo sapiens	54-58
20720296-4	2010	In this work we study the physical properties and the spin-polarization effects of p-type DMH based in group-IV semiconductors (Si, Ge, SiGe, and SiC), by performing self-consistent [Formula: see text] calculations in the local spin density approximation.	1,2-Dimethylhydrazine	90-93	spindlin 1	Homo sapiens	228-232
20720296-7	2010	Partial, but still important spin polarization can be achieved for all studied group-IV DMH, with the exception of Ge for carrier concentrations up to 6.0 x 10(19) cm(-3).	1,2-Dimethylhydrazine	88-91	spindlin 1	Homo sapiens	29-33
20537993-3	2010	Our aim was to explore the modulatory effect of silibinin on beta-catenin expression employing 1,2-dimethylhydrazine (DMH) induced colon cancer in male Wistar rats as an experimental model during the different stages of carcinogenesis.	1,2-Dimethylhydrazine	118-121	catenin beta 1	Rattus norvegicus	61-73
20537993-8	2010	Silibinin supplementation to DMH-treated rats restored the levels of GSH-dependent enzymes and decreased the levels of beta-catenin, PCNA, argyrophilic nucleolar organizer regions and cyclin D1.	1,2-Dimethylhydrazine	29-32	catenin beta 1	Rattus norvegicus	119-131
20537993-8	2010	Silibinin supplementation to DMH-treated rats restored the levels of GSH-dependent enzymes and decreased the levels of beta-catenin, PCNA, argyrophilic nucleolar organizer regions and cyclin D1.	1,2-Dimethylhydrazine	29-32	cyclin D1	Rattus norvegicus	184-193
20537993-9	2010	Mechanistically silibinin inhibits DMH-induced colon carcinogenesis by modulating the Wnt/beta-catenin pathway and glutathione redox system.	1,2-Dimethylhydrazine	35-38	catenin beta 1	Rattus norvegicus	90-102
20485182-1	2010	The role of peroxisome proliferator-activated receptor gamma (PPARgamma) was investigated in 1,2-dimethylhydrazine dihydrochloride (DMH)-induced colon carcinogenesis for 6 weeks (early stage) and its chemoprevention by diclofenac in a rat model.	1,2-Dimethylhydrazine	132-135	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	12-60
20485182-1	2010	The role of peroxisome proliferator-activated receptor gamma (PPARgamma) was investigated in 1,2-dimethylhydrazine dihydrochloride (DMH)-induced colon carcinogenesis for 6 weeks (early stage) and its chemoprevention by diclofenac in a rat model.	1,2-Dimethylhydrazine	132-135	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	62-71
20485182-4	2010	The colonic mucosa showed increased protein expression and the enhanced activity of COX-2 in the DMH group, whereas the constitutively expressed COX-1 remained unaltered.	1,2-Dimethylhydrazine	97-100	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	84-89
20485182-7	2010	PPARgamma expression was found to be decreased after DMH treatment as seen both by western blot and immunohistochemistry.	1,2-Dimethylhydrazine	53-56	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	0-9
20485182-8	2010	In addition, the protein expression of the apoptotic protease activating factor-1 was studied in the colonic mucosa to observe the role of apoptosis in this study, which showed a distinct decline in the DMH-treated animals.	1,2-Dimethylhydrazine	203-206	apoptotic peptidase activating factor 1	Rattus norvegicus	43-81
20087880-5	2010	There was a significant increase in both the number and the size of colonic adenomas in DMH-treated K-ras(tmDelta4A/tmDelta4A) mice, with reduced survival, compared with heterozygous and wild-type mice.	1,2-Dimethylhydrazine	88-91	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	100-105
20197492-4	2010	In contrast, morphologically normal colon from DMH-treated rats and dysplastic aberrant crypt foci were strongly stained, indicating that increased Gal-3 expression is an early event during the neoplastic transformation in colon cells.	1,2-Dimethylhydrazine	47-50	galectin 3	Rattus norvegicus	148-153
20197492-6	2010	Overall, the Gal-3 expression pattern observed in the DMH rat model closely resembles that displayed by human colon stained with the same antibodies.	1,2-Dimethylhydrazine	54-57	galectin 3	Rattus norvegicus	13-18
20197492-9	2010	In conclusion, the DMH-induced rat colon cancer model displays expression patterns of Gal-3 and its ligands very similar to those observed in human samples.	1,2-Dimethylhydrazine	19-22	galectin 3	Rattus norvegicus	86-91
20087880-9	2010	In conclusion, following DMH treatment, K-ras exon 4A deletion promoted increased number and size of colonic adenomas showing increased K-ras 4B expression, increased proliferation, decreased apoptosis, and activation of MapKinase and Akt pathways, in the absence of K-ras mutations.	1,2-Dimethylhydrazine	25-28	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	40-45
21198281-0	2010	Inhibition of 1, 2-dimethylhydrazine-induced mucin-depleted foci and O6-methylguanine DNA adducts in the rat colorectum by boiled garlic powder.	1,2-Dimethylhydrazine	14-36	solute carrier family 13 member 2	Rattus norvegicus	45-50
20210849-5	2010	GPR50 immunoreactivity (ir) was observed in dorsomedial hypothalamic (DMH) cells co-stained with the neuronal marker HuC/D.	1,2-Dimethylhydrazine	70-73	G protein-coupled receptor 50	Homo sapiens	0-5
21198281-2	2010	We therefore examined the modifying effect of boiled garlic powder (BGP) on 1,2-dimethylhydrazine-induced mucin-depleted foci (MDF) and aberrant crypt foci (ACF), preneoplastic lesions, in the rat colorectum.	1,2-Dimethylhydrazine	76-97	solute carrier family 13 member 2	Rattus norvegicus	106-111
21198287-7	2010	Expression of proliferative cell nuclear antigen (PCNA), assessed by Western blot analysis and immunohistochemistry, was found to be elevated by DMH treatment group and again reduced by etoricoxib.	1,2-Dimethylhydrazine	145-148	proliferating cell nuclear antigen	Rattus norvegicus	50-54
19470705-8	2009	The lactation-induced increase in DMH NPY was unchanged after treatments.	1,2-Dimethylhydrazine	34-37	neuropeptide Y	Rattus norvegicus	38-41
20528746-5	2010	The colonic tissue showed increased COX-2 expression in the DMH group, immunohistochemically and by western blotting.	1,2-Dimethylhydrazine	60-63	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	36-41
19642015-6	2010	The c-myc and cox-2 mRNA level was found highest in DMH control group as compared to WB-DMH and WB-DMH-Ac Dahi group.	1,2-Dimethylhydrazine	52-55	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	4-9
19642015-6	2010	The c-myc and cox-2 mRNA level was found highest in DMH control group as compared to WB-DMH and WB-DMH-Ac Dahi group.	1,2-Dimethylhydrazine	52-55	cox2	Triticum aestivum	14-19
20681407-8	2010	DMH treatment reduced the mitochondrial translocation of Bax whereas cytochrome c was found to be located prominently in the mitochondria.	1,2-Dimethylhydrazine	0-3	BCL2 associated X, apoptosis regulator	Rattus norvegicus	57-60
20681407-9	2010	Protein expression of antiapoptotic Bcl-2 was also studied in the colonic mucosa, which was expectedly found to be overexpressed after DMH treatment.	1,2-Dimethylhydrazine	135-138	BCL2, apoptosis regulator	Rattus norvegicus	36-41
20049376-1	2009	The chemopreventive response was evaluated of nonsteroidal anti-inflammatory drug, Diclofenac, a preferential cyclooxygenase-2 (COX-2) inhibitor in 1,2-dimethyhydrazine (DMH)-induced colon cancer in rat model.	1,2-Dimethylhydrazine	170-173	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	110-126
20049376-1	2009	The chemopreventive response was evaluated of nonsteroidal anti-inflammatory drug, Diclofenac, a preferential cyclooxygenase-2 (COX-2) inhibitor in 1,2-dimethyhydrazine (DMH)-induced colon cancer in rat model.	1,2-Dimethylhydrazine	170-173	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	128-133
20049376-5	2009	A very high expression of COX-2 was seen in the colonic epithelium of DMH-treated rats, as analyzed by immunohistochemistry.	1,2-Dimethylhydrazine	70-73	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	26-31
20495296-7	2010	Colonic mucosa of DMH-injected rats had significantly greater COX-2 and iNOS gene expression than those of control rats, while treatment with CoQ10 induced an inhibitory effect on over-expression of COX-2 and iNOS in colon tumors.	1,2-Dimethylhydrazine	18-21	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	62-67
20495296-7	2010	Colonic mucosa of DMH-injected rats had significantly greater COX-2 and iNOS gene expression than those of control rats, while treatment with CoQ10 induced an inhibitory effect on over-expression of COX-2 and iNOS in colon tumors.	1,2-Dimethylhydrazine	18-21	nitric oxide synthase 2	Rattus norvegicus	72-76
20495296-7	2010	Colonic mucosa of DMH-injected rats had significantly greater COX-2 and iNOS gene expression than those of control rats, while treatment with CoQ10 induced an inhibitory effect on over-expression of COX-2 and iNOS in colon tumors.	1,2-Dimethylhydrazine	18-21	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	199-204
20495296-7	2010	Colonic mucosa of DMH-injected rats had significantly greater COX-2 and iNOS gene expression than those of control rats, while treatment with CoQ10 induced an inhibitory effect on over-expression of COX-2 and iNOS in colon tumors.	1,2-Dimethylhydrazine	18-21	nitric oxide synthase 2	Rattus norvegicus	209-213
19915331-7	2010	Four weeks after the first DMH administration, the glutathione S-transferase placental form (GST-P)-positive foci induced by DMH in the liver was measured immunohistochemically.	1,2-Dimethylhydrazine	125-128	glutathione S-transferase pi 1	Rattus norvegicus	51-98
19915331-8	2010	The inductions of GST-P-positive foci in all DMH-treated groups were dose-dependent, duration-dependent and significantly higher than that in non-DMH-treated group.	1,2-Dimethylhydrazine	45-48	glutathione S-transferase pi 1	Rattus norvegicus	18-23
19915331-8	2010	The inductions of GST-P-positive foci in all DMH-treated groups were dose-dependent, duration-dependent and significantly higher than that in non-DMH-treated group.	1,2-Dimethylhydrazine	146-149	glutathione S-transferase pi 1	Rattus norvegicus	18-23
20204254-11	2010	The cytoplasmic expression of COX-2 protein was studied in paraffin sections of the colon by immunohistochemistry with COX-2 specific antibody which showed a very high presence of this inducible enzyme with the DMH group while in all other groups of animals it was not visible or weekly expressed.	1,2-Dimethylhydrazine	211-214	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	30-35
20204254-11	2010	The cytoplasmic expression of COX-2 protein was studied in paraffin sections of the colon by immunohistochemistry with COX-2 specific antibody which showed a very high presence of this inducible enzyme with the DMH group while in all other groups of animals it was not visible or weekly expressed.	1,2-Dimethylhydrazine	211-214	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	119-124
21160778-8	2009	Levels of lipid peroxidation, glutathione-S-transferase, superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) decreased following DMH treatment, whereas levels of glutathione (GSH) and glutathione reductase (GR) significantly increased in DMH treated rats.	1,2-Dimethylhydrazine	148-151	hematopoietic prostaglandin D synthase	Rattus norvegicus	30-55
21160778-8	2009	Levels of lipid peroxidation, glutathione-S-transferase, superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) decreased following DMH treatment, whereas levels of glutathione (GSH) and glutathione reductase (GR) significantly increased in DMH treated rats.	1,2-Dimethylhydrazine	148-151	catalase	Rattus norvegicus	85-93
21160778-8	2009	Levels of lipid peroxidation, glutathione-S-transferase, superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) decreased following DMH treatment, whereas levels of glutathione (GSH) and glutathione reductase (GR) significantly increased in DMH treated rats.	1,2-Dimethylhydrazine	148-151	glutathione-disulfide reductase	Rattus norvegicus	203-224
21160778-8	2009	Levels of lipid peroxidation, glutathione-S-transferase, superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) decreased following DMH treatment, whereas levels of glutathione (GSH) and glutathione reductase (GR) significantly increased in DMH treated rats.	1,2-Dimethylhydrazine	148-151	glutathione-disulfide reductase	Rattus norvegicus	226-228
21160778-9	2009	Selenium administration to DMH treated rats led to an increase in the levels of lipid peroxidation, SOD, catalase, glutathione-S-transferase and GPx, but decreased the levels of GSH and GR.	1,2-Dimethylhydrazine	27-30	catalase	Rattus norvegicus	105-113
21160778-9	2009	Selenium administration to DMH treated rats led to an increase in the levels of lipid peroxidation, SOD, catalase, glutathione-S-transferase and GPx, but decreased the levels of GSH and GR.	1,2-Dimethylhydrazine	27-30	hematopoietic prostaglandin D synthase	Rattus norvegicus	115-140
21160778-9	2009	Selenium administration to DMH treated rats led to an increase in the levels of lipid peroxidation, SOD, catalase, glutathione-S-transferase and GPx, but decreased the levels of GSH and GR.	1,2-Dimethylhydrazine	27-30	glutathione-disulfide reductase	Rattus norvegicus	186-188
19470705-11	2009	The chronic hyperphagia of lactation is most likely sustained by the induction of NPY in the DMH.	1,2-Dimethylhydrazine	93-96	neuropeptide Y	Rattus norvegicus	82-85
19431205-0	2009	Mucin-depleted foci show strong activation of inflammatory markers in 1,2-dimethylhydrazine-induced carcinogenesis and are promoted by the inflammatory agent sodium dextran sulfate.	1,2-Dimethylhydrazine	70-91	LOC100508689	Homo sapiens	0-5
19417676-7	2009	The results showed that 1,2-dimethylhydrazine significantly increased total aberrant crypt foci formation, total number of dysplastic foci, beta-catenin accumulated crypts and proliferating cell nuclear antigen labeling index in the colon, and enhanced lipid peroxidation markers and decreased enzymic antioxidant activities in the plasma and erythrocyte lysate as compared with untreated controls.	1,2-Dimethylhydrazine	24-45	catenin beta 1	Rattus norvegicus	140-152
19327390-2	2009	EP3 receptor (EP3R)-expressing POA neurons project directly to the dorsomedial hypothalamus (DMH) and to the rostral raphe pallidus nucleus (rRPa), key sites for the control of thermoregulatory effectors.	1,2-Dimethylhydrazine	93-96	prostaglandin E receptor 3	Rattus norvegicus	0-3
19327390-2	2009	EP3 receptor (EP3R)-expressing POA neurons project directly to the dorsomedial hypothalamus (DMH) and to the rostral raphe pallidus nucleus (rRPa), key sites for the control of thermoregulatory effectors.	1,2-Dimethylhydrazine	93-96	prostaglandin E receptor 3	Rattus norvegicus	14-18
19327390-4	2009	In this case, DMH-projecting and rRPa-projecting neurons would constitute segregated populations within the EP3R-expressing neuronal group in the POA.	1,2-Dimethylhydrazine	14-17	prostaglandin E receptor 3	Rattus norvegicus	108-112
19327390-6	2009	We found substantial numbers of EP3R-immunoreactive neurons in both the DMH-projecting and the rRPa-projecting populations.	1,2-Dimethylhydrazine	72-75	prostaglandin E receptor 3	Rattus norvegicus	32-36
19327390-8	2009	The paucity of the EP3R-expressing neurons that send collaterals to both the DMH and the rRPa suggests that pyrogenic signals are sent independently to these caudal brain regions from the POA and that such pyrogenic outputs from the POA reflect different control mechanisms for BAT thermogenesis and for cutaneous vasoconstriction by distinct sets of POA neurons.	1,2-Dimethylhydrazine	77-80	prostaglandin E receptor 3	Rattus norvegicus	19-23
19371745-3	2009	Recent studies suggest that CORT inhibits postsynaptic clearance of 5-HT from the extracellular fluid in the DMH by blocking organic cation transporter 3 (OCT3), a polyspecific CORT-sensitive transport protein.	1,2-Dimethylhydrazine	109-112	cortistatin	Rattus norvegicus	28-32
19458067-6	2009	For in vivo studies, 1,2-dimethylhydrazine dihydrochloride (DMH) was s.c. injected to induce colon cancer in PPARgamma(+/+) and PPARgamma(+/-) mice.	1,2-Dimethylhydrazine	60-63	peroxisome proliferator activated receptor gamma	Mus musculus	109-118
19458067-6	2009	For in vivo studies, 1,2-dimethylhydrazine dihydrochloride (DMH) was s.c. injected to induce colon cancer in PPARgamma(+/+) and PPARgamma(+/-) mice.	1,2-Dimethylhydrazine	60-63	peroxisome proliferator activated receptor gamma	Mus musculus	128-137
19458067-11	2009	PPARgamma(+/-) mice were more susceptible to DMH-induced colon carcinogenesis than PPARgamma(+/+) mice, and embelin significantly reduced the incidence of colon cancer in PPARgamma(+/+) mice but not in PPARgamma(+/-) mice.	1,2-Dimethylhydrazine	45-48	peroxisome proliferator activated receptor gamma	Mus musculus	0-9
19458067-13	2009	Thus, reduced expression of PPARgamma significantly sensitizes colonic tissues to the carcinogenic effect of DMH.	1,2-Dimethylhydrazine	109-112	peroxisome proliferator activated receptor gamma	Mus musculus	28-37
19371745-2	2009	In vertebrates, DMH serotonin (5-HT) concentrations increase rapidly in response to acute stressors or corticosterone (CORT).	1,2-Dimethylhydrazine	16-19	cortistatin	Rattus norvegicus	119-123
18648748-8	2009	Administration of hesperetin to DMH treated rats significantly decreased the tumor incidence, the number of aberrant crypt foci with simultaneous enhancement of tissue lipid peroxidation, GST, GPx, SOD, and CAT activities.	1,2-Dimethylhydrazine	32-35	catalase	Rattus norvegicus	207-210
19184365-4	2009	Interestingly, the results in this study revealed that SNL glycoprotein has suppressive effects on activity of nuclear factor-kappa B (NF-kappaB), whereas it has stimulatory effect on the expression of p53, accompanying inhibitory effects on expression of NF-kappaBp50, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin (IL)-6, and tumor necrosis factor (TNF)-alpha in DMH-stimulated ACF formation.	1,2-Dimethylhydrazine	397-400	transformation related protein 53, pseudogene	Mus musculus	202-205
19371745-3	2009	Recent studies suggest that CORT inhibits postsynaptic clearance of 5-HT from the extracellular fluid in the DMH by blocking organic cation transporter 3 (OCT3), a polyspecific CORT-sensitive transport protein.	1,2-Dimethylhydrazine	109-112	solute carrier family 22 member 3	Rattus norvegicus	125-153
19371745-3	2009	Recent studies suggest that CORT inhibits postsynaptic clearance of 5-HT from the extracellular fluid in the DMH by blocking organic cation transporter 3 (OCT3), a polyspecific CORT-sensitive transport protein.	1,2-Dimethylhydrazine	109-112	solute carrier family 22 member 3	Rattus norvegicus	155-159
19371745-3	2009	Recent studies suggest that CORT inhibits postsynaptic clearance of 5-HT from the extracellular fluid in the DMH by blocking organic cation transporter 3 (OCT3), a polyspecific CORT-sensitive transport protein.	1,2-Dimethylhydrazine	109-112	cortistatin	Rattus norvegicus	177-181
19371745-5	2009	We predicted that local application of CORT into the DMH would potentiate the effects of d-fenfluramine, a 5-HT-releasing agent, on extracellular 5-HT.	1,2-Dimethylhydrazine	53-56	cortistatin	Rattus norvegicus	39-43
19129396-3	2009	We found that AAV-mediated overexpression of NPY in the DMH of lean rats increased food intake and body weight, and exacerbated high-fat diet-induced obesity.	1,2-Dimethylhydrazine	56-59	neuropeptide Y	Rattus norvegicus	45-48
19377624-11	2009	RESULTS: (1) Sulindac and agonist of PPAR-gamma could significantly inhibit DMH-induced ACFs of rats from 137.8+/-59.4 to 73.9+/-32.1 and 96.4+/-32.6 with a decrease of 45.7% (P&lt;0.01) and 30.0%(P&lt;0.05) compared with DMH group.	1,2-Dimethylhydrazine	76-79	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	37-47
19377624-11	2009	RESULTS: (1) Sulindac and agonist of PPAR-gamma could significantly inhibit DMH-induced ACFs of rats from 137.8+/-59.4 to 73.9+/-32.1 and 96.4+/-32.6 with a decrease of 45.7% (P&lt;0.01) and 30.0%(P&lt;0.05) compared with DMH group.	1,2-Dimethylhydrazine	222-225	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	37-47
19377624-13	2009	CONCLUSION: The expression of PPAR-gamma had risen in DMH-induced ACFs of rats significantly.	1,2-Dimethylhydrazine	54-57	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	30-40
19377624-16	2009	PPAR-gamma might play an important role in the chemopreventive effect of sulindac on colorectal pre-cancerous lesions of rats and activation of PPAR-gamma pathway could inhibit the initiation and evolvement of ACF induced by DMH.	1,2-Dimethylhydrazine	225-228	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	144-154
19469017-9	2009	Colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) plus dextran sulfate sodium (DSS) was also reduced in SOCS1-cKO mice.	1,2-Dimethylhydrazine	32-53	suppressor of cytokine signaling 1	Mus musculus	114-119
19469017-9	2009	Colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) plus dextran sulfate sodium (DSS) was also reduced in SOCS1-cKO mice.	1,2-Dimethylhydrazine	55-58	suppressor of cytokine signaling 1	Mus musculus	114-119
18937552-2	2009	CEA transgenic (CEA.Tg) mice treated with the carcinogen 1,2-dimethylhydrazine developed CEA-overexpressing tumors that resembled human sporadic colorectal cancer.	1,2-Dimethylhydrazine	57-78	carcinoembryonic antigen gene family	Mus musculus	0-3
18937552-2	2009	CEA transgenic (CEA.Tg) mice treated with the carcinogen 1,2-dimethylhydrazine developed CEA-overexpressing tumors that resembled human sporadic colorectal cancer.	1,2-Dimethylhydrazine	57-78	carcinoembryonic antigen gene family	Mus musculus	16-19
18937552-2	2009	CEA transgenic (CEA.Tg) mice treated with the carcinogen 1,2-dimethylhydrazine developed CEA-overexpressing tumors that resembled human sporadic colorectal cancer.	1,2-Dimethylhydrazine	57-78	carcinoembryonic antigen gene family	Mus musculus	16-19
19129396-4	2009	Knockdown of NPY expression in the DMH via AAV-mediated RNA interference ameliorated the hyperphagia, obesity, and diabetes of Otsuka Long-Evans Tokushima Fatty (OLETF) rats.	1,2-Dimethylhydrazine	35-38	neuropeptide Y	Rattus norvegicus	13-16
19129396-5	2009	NPY knockdown in the DMH produced a nocturnal and meal size-specific feeding effect.	1,2-Dimethylhydrazine	21-24	neuropeptide Y	Rattus norvegicus	0-3
19129396-7	2009	DMH NPY knockdown increased the feeding inhibitory and NTS c-Fos responses to peripheral administration of cholecystokinin.	1,2-Dimethylhydrazine	0-3	neuropeptide Y	Rattus norvegicus	4-7
19129396-7	2009	DMH NPY knockdown increased the feeding inhibitory and NTS c-Fos responses to peripheral administration of cholecystokinin.	1,2-Dimethylhydrazine	0-3	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	59-64
20104973-0	2009	Inhibitory effects of high temperature- and pressure-treated garlic on formation of 1,2-dimethylhydrazine-induced mucin-depleted foci and O(6)-methylguanine DNA adducts in the rat colorectum.	1,2-Dimethylhydrazine	84-105	solute carrier family 13 member 2	Rattus norvegicus	114-119
20104973-3	2009	This study first examined the modifying effects of HTPG on 1,2-dimethylhydrazine (DMH)-induced mucin-depleted foci (MDF) and aberrant crypt foci (ACF), preneoplastic lesions in the rat colorectum.	1,2-Dimethylhydrazine	59-80	solute carrier family 13 member 2	Rattus norvegicus	95-100
20104973-3	2009	This study first examined the modifying effects of HTPG on 1,2-dimethylhydrazine (DMH)-induced mucin-depleted foci (MDF) and aberrant crypt foci (ACF), preneoplastic lesions in the rat colorectum.	1,2-Dimethylhydrazine	82-85	solute carrier family 13 member 2	Rattus norvegicus	95-100
20192600-13	2009	Studies of a nuclear transcription factor (NF-kB) and COX-2 by Western blot analysis and immunohistochemistry demonstrated expression of both to be elevated in the DMH treated group but reduced in the DMH + Etoricoxib group.	1,2-Dimethylhydrazine	164-167	nuclear factor kappa B subunit 1	Rattus norvegicus	43-48
20104973-15	2009	HTPG significantly reduced the activity of cytochrome P450 (CYP) 2E1, known to be responsible for activation of DMH in rat liver (p&lt; 0.05).	1,2-Dimethylhydrazine	112-115	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	43-68
20192600-13	2009	Studies of a nuclear transcription factor (NF-kB) and COX-2 by Western blot analysis and immunohistochemistry demonstrated expression of both to be elevated in the DMH treated group but reduced in the DMH + Etoricoxib group.	1,2-Dimethylhydrazine	164-167	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	54-59
20192600-13	2009	Studies of a nuclear transcription factor (NF-kB) and COX-2 by Western blot analysis and immunohistochemistry demonstrated expression of both to be elevated in the DMH treated group but reduced in the DMH + Etoricoxib group.	1,2-Dimethylhydrazine	201-204	nuclear factor kappa B subunit 1	Rattus norvegicus	43-48
19392653-1	2009	Cyclooxygenase-2 (COX-2), an inducible prostaglandin G/H synthase, is overexpressed in several human cancers, including colon cancer, and therefore the potential ability of a selective COX-2 inhibitor, etoricoxib, is considered in the prevention of the 1,2-dimethyl hydrazine (DMH)-induced colon carcinogenesis in the rat model.	1,2-Dimethylhydrazine	253-275	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-16
20192600-13	2009	Studies of a nuclear transcription factor (NF-kB) and COX-2 by Western blot analysis and immunohistochemistry demonstrated expression of both to be elevated in the DMH treated group but reduced in the DMH + Etoricoxib group.	1,2-Dimethylhydrazine	201-204	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	54-59
19392653-1	2009	Cyclooxygenase-2 (COX-2), an inducible prostaglandin G/H synthase, is overexpressed in several human cancers, including colon cancer, and therefore the potential ability of a selective COX-2 inhibitor, etoricoxib, is considered in the prevention of the 1,2-dimethyl hydrazine (DMH)-induced colon carcinogenesis in the rat model.	1,2-Dimethylhydrazine	277-280	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-16
19392653-1	2009	Cyclooxygenase-2 (COX-2), an inducible prostaglandin G/H synthase, is overexpressed in several human cancers, including colon cancer, and therefore the potential ability of a selective COX-2 inhibitor, etoricoxib, is considered in the prevention of the 1,2-dimethyl hydrazine (DMH)-induced colon carcinogenesis in the rat model.	1,2-Dimethylhydrazine	253-275	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-23
19392653-1	2009	Cyclooxygenase-2 (COX-2), an inducible prostaglandin G/H synthase, is overexpressed in several human cancers, including colon cancer, and therefore the potential ability of a selective COX-2 inhibitor, etoricoxib, is considered in the prevention of the 1,2-dimethyl hydrazine (DMH)-induced colon carcinogenesis in the rat model.	1,2-Dimethylhydrazine	277-280	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-23
19392653-6	2009	COX-2 was also seen to be highly expressed following DMH treatment.	1,2-Dimethylhydrazine	53-56	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-5
18667366-5	2008	In this study we showed that intracisternal injection of a low dose (1 microg/kg) of the 5-HT(1A) receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), significantly reduced the increases in heart rate and renal sympathetic nerve activity evoked by disinhibition of the DMH, but had no effect on these responses when injected intravenously.	1,2-Dimethylhydrazine	286-289	5-hydroxytryptamine receptor 1A	Homo sapiens	89-106
18667366-6	2008	Subsequent intracisternal administration of the 5-HT(1A) receptor antagonist WAY-100635 restored the DMH-evoked cardiovascular responses to levels observed before 8-OH-DPAT administration.	1,2-Dimethylhydrazine	101-104	5-hydroxytryptamine receptor 1A	Homo sapiens	48-65
18058797-0	2008	The expression of low molecular weight protein tyrosine phosphatase is up-regulated in 1,2-dimethylhydrazine-induced colon tumours in rats.	1,2-Dimethylhydrazine	87-108	acid phosphatase 1	Homo sapiens	18-67
18812032-9	2008	In DMH-treated rats, the activity of faecal and colonic mucosal bacterial enzymes, such as beta-glucuronidase, beta-galactosidase, beta-glucosidase, nitroreductase, sulfatase and mucinase, were significantly elevated, but in rats supplemented hesperetin along with DMH the activity was significantly lowered (P &lt; 0.05).	1,2-Dimethylhydrazine	3-6	glucuronidase, beta	Rattus norvegicus	91-109
18812032-9	2008	In DMH-treated rats, the activity of faecal and colonic mucosal bacterial enzymes, such as beta-glucuronidase, beta-galactosidase, beta-glucosidase, nitroreductase, sulfatase and mucinase, were significantly elevated, but in rats supplemented hesperetin along with DMH the activity was significantly lowered (P &lt; 0.05).	1,2-Dimethylhydrazine	3-6	galactosidase, beta 1	Rattus norvegicus	111-129
18498716-10	2008	The levels of the anti-oxidants superoxide dismutase, catalase, reduced glutathione, glutathione reductase, glutathione peroxidase and glutathione-S-transferase were decreased in DMH-treated rats, but were significantly reversed on oregano supplementation.	1,2-Dimethylhydrazine	179-182	catalase	Rattus norvegicus	54-62
18498716-10	2008	The levels of the anti-oxidants superoxide dismutase, catalase, reduced glutathione, glutathione reductase, glutathione peroxidase and glutathione-S-transferase were decreased in DMH-treated rats, but were significantly reversed on oregano supplementation.	1,2-Dimethylhydrazine	179-182	glutathione-disulfide reductase	Rattus norvegicus	85-106
18498716-10	2008	The levels of the anti-oxidants superoxide dismutase, catalase, reduced glutathione, glutathione reductase, glutathione peroxidase and glutathione-S-transferase were decreased in DMH-treated rats, but were significantly reversed on oregano supplementation.	1,2-Dimethylhydrazine	179-182	hematopoietic prostaglandin D synthase	Rattus norvegicus	135-160
19129396-2	2009	To elucidate such actions, we used the adenoassociated virus (AAV) system to alter Npy gene expression in the DMH and examined the effects of these alterations on food intake and energy balance as well as explored its downstream signaling pathway.	1,2-Dimethylhydrazine	110-113	neuropeptide Y	Rattus norvegicus	83-86
18586013-3	2008	We therefore tested the hypothesis that neuronal activity in the DMH plays a role in MDMA-evoked sympathetic and behavioral responses by microinjecting artificial CSF or muscimol, a neuronal inhibitor, into the DMH prior to intravenous infusion of saline or MDMA in conscious rats.	1,2-Dimethylhydrazine	65-68	colony stimulating factor 2	Rattus norvegicus	163-166
18614159-3	2008	DMH neurons expressing the peptide neurotransmitter orexin/hypocretin are ideally situated to act as a relay between SCN and LC due to their synaptic inputs from SCN and innervation of LC.	1,2-Dimethylhydrazine	0-3	hypocretin neuropeptide precursor	Rattus norvegicus	52-58
17847023-0	2008	K-ras mutations and mucin profile in preneoplastic lesions and colon tumors induced in rats by 1,2-dimethylhydrazine.	1,2-Dimethylhydrazine	95-116	KRAS proto-oncogene, GTPase	Rattus norvegicus	0-5
18282559-2	2008	Here, we examined the effect of disinhibition of the DMH by unilateral microinjection of bicuculline methiodide (BMI) on Fos expression in selected regions of the brain that have been implicated in anxiety and responses to stress and fever in rats.	1,2-Dimethylhydrazine	53-56	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	121-124
18282559-3	2008	Disinhibition of the DMH resulted in dramatic increases in local Fos expression and also increased the numbers of Fos-positive neurons in the lateral septal nucleus and in both the parvocellular and magnocellular subdivisions of the paraventricular nucleus, with greater increases ipsilateral to the injection site in the DMH.	1,2-Dimethylhydrazine	21-24	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	65-68
18282559-3	2008	Disinhibition of the DMH resulted in dramatic increases in local Fos expression and also increased the numbers of Fos-positive neurons in the lateral septal nucleus and in both the parvocellular and magnocellular subdivisions of the paraventricular nucleus, with greater increases ipsilateral to the injection site in the DMH.	1,2-Dimethylhydrazine	21-24	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	114-117
18282559-5	2008	In the brainstem, disinhibition of the DMH increased Fos expression in the nucleus tractus solitarius and the ventrolateral medulla bilaterally with greater increases again ipsilateral to the site of the microinjection, and also in the midline rostral raphe pallidus.	1,2-Dimethylhydrazine	39-42	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	53-56
18282559-6	2008	Thus, disinhibition of neurons in the DMH in conscious rats results in increases in Fos expression in selected forebrain and brainstem regions that have been implicated in stress-induced physiological changes, anxiety, and experimental fever.	1,2-Dimethylhydrazine	38-41	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	84-87
18248910-3	2008	We sought to characterize the feeding inhibition and brain neural activation produced by CCK administration into the DMH of rats.	1,2-Dimethylhydrazine	117-120	cholecystokinin	Rattus norvegicus	89-92
18248910-4	2008	We determined the time course of feeding inhibitory effects of exogenous DMH CCK, assessed NPY gene expression in the DMH in response to DMH CCK administration, and characterized c-Fos activation in the entire brain induced by CCK injection into the DMH using c-Fos like immunohistochemistry.	1,2-Dimethylhydrazine	118-121	neuropeptide Y	Rattus norvegicus	91-94
18248910-4	2008	We determined the time course of feeding inhibitory effects of exogenous DMH CCK, assessed NPY gene expression in the DMH in response to DMH CCK administration, and characterized c-Fos activation in the entire brain induced by CCK injection into the DMH using c-Fos like immunohistochemistry.	1,2-Dimethylhydrazine	118-121	cholecystokinin	Rattus norvegicus	141-144
18248910-4	2008	We determined the time course of feeding inhibitory effects of exogenous DMH CCK, assessed NPY gene expression in the DMH in response to DMH CCK administration, and characterized c-Fos activation in the entire brain induced by CCK injection into the DMH using c-Fos like immunohistochemistry.	1,2-Dimethylhydrazine	118-121	cholecystokinin	Rattus norvegicus	141-144
18248910-4	2008	We determined the time course of feeding inhibitory effects of exogenous DMH CCK, assessed NPY gene expression in the DMH in response to DMH CCK administration, and characterized c-Fos activation in the entire brain induced by CCK injection into the DMH using c-Fos like immunohistochemistry.	1,2-Dimethylhydrazine	118-121	neuropeptide Y	Rattus norvegicus	91-94
18248910-4	2008	We determined the time course of feeding inhibitory effects of exogenous DMH CCK, assessed NPY gene expression in the DMH in response to DMH CCK administration, and characterized c-Fos activation in the entire brain induced by CCK injection into the DMH using c-Fos like immunohistochemistry.	1,2-Dimethylhydrazine	118-121	cholecystokinin	Rattus norvegicus	141-144
18248910-4	2008	We determined the time course of feeding inhibitory effects of exogenous DMH CCK, assessed NPY gene expression in the DMH in response to DMH CCK administration, and characterized c-Fos activation in the entire brain induced by CCK injection into the DMH using c-Fos like immunohistochemistry.	1,2-Dimethylhydrazine	118-121	cholecystokinin	Rattus norvegicus	141-144
18248910-4	2008	We determined the time course of feeding inhibitory effects of exogenous DMH CCK, assessed NPY gene expression in the DMH in response to DMH CCK administration, and characterized c-Fos activation in the entire brain induced by CCK injection into the DMH using c-Fos like immunohistochemistry.	1,2-Dimethylhydrazine	118-121	neuropeptide Y	Rattus norvegicus	91-94
18248910-4	2008	We determined the time course of feeding inhibitory effects of exogenous DMH CCK, assessed NPY gene expression in the DMH in response to DMH CCK administration, and characterized c-Fos activation in the entire brain induced by CCK injection into the DMH using c-Fos like immunohistochemistry.	1,2-Dimethylhydrazine	118-121	cholecystokinin	Rattus norvegicus	141-144
18248910-4	2008	We determined the time course of feeding inhibitory effects of exogenous DMH CCK, assessed NPY gene expression in the DMH in response to DMH CCK administration, and characterized c-Fos activation in the entire brain induced by CCK injection into the DMH using c-Fos like immunohistochemistry.	1,2-Dimethylhydrazine	118-121	cholecystokinin	Rattus norvegicus	141-144
18248910-5	2008	We found that parenchymal injection of CCK into the DMH decreased food intake during the entire 22 h observation period, with a primary effect in the first 4 h, and down-regulated NPY gene expression in the DMH.	1,2-Dimethylhydrazine	52-55	cholecystokinin	Rattus norvegicus	39-42
18248910-5	2008	We found that parenchymal injection of CCK into the DMH decreased food intake during the entire 22 h observation period, with a primary effect in the first 4 h, and down-regulated NPY gene expression in the DMH.	1,2-Dimethylhydrazine	52-55	neuropeptide Y	Rattus norvegicus	180-183
18248910-5	2008	We found that parenchymal injection of CCK into the DMH decreased food intake during the entire 22 h observation period, with a primary effect in the first 4 h, and down-regulated NPY gene expression in the DMH.	1,2-Dimethylhydrazine	207-210	cholecystokinin	Rattus norvegicus	39-42
18248910-5	2008	We found that parenchymal injection of CCK into the DMH decreased food intake during the entire 22 h observation period, with a primary effect in the first 4 h, and down-regulated NPY gene expression in the DMH.	1,2-Dimethylhydrazine	207-210	neuropeptide Y	Rattus norvegicus	180-183
18248910-6	2008	c-Fos immunohistochemistry revealed that DMH CCK increased the number of c-Fos positive cells in the paraventricular nucleus (PVN), arcuate nucleus, suprachiasmatic nucleus and retrochiasmatic area as well as in the contralateral DMH.	1,2-Dimethylhydrazine	41-44	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
18248910-6	2008	c-Fos immunohistochemistry revealed that DMH CCK increased the number of c-Fos positive cells in the paraventricular nucleus (PVN), arcuate nucleus, suprachiasmatic nucleus and retrochiasmatic area as well as in the contralateral DMH.	1,2-Dimethylhydrazine	41-44	cholecystokinin	Rattus norvegicus	45-48
18248910-6	2008	c-Fos immunohistochemistry revealed that DMH CCK increased the number of c-Fos positive cells in the paraventricular nucleus (PVN), arcuate nucleus, suprachiasmatic nucleus and retrochiasmatic area as well as in the contralateral DMH.	1,2-Dimethylhydrazine	41-44	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	73-78
18248910-6	2008	c-Fos immunohistochemistry revealed that DMH CCK increased the number of c-Fos positive cells in the paraventricular nucleus (PVN), arcuate nucleus, suprachiasmatic nucleus and retrochiasmatic area as well as in the contralateral DMH.	1,2-Dimethylhydrazine	230-233	cholecystokinin	Rattus norvegicus	45-48
18248910-7	2008	This pattern of activity is different from that produced by peripherally administered CCK which is short acting and primarily activates neurons in the nucleus of the solitary tract and area postrema, as well as the PVN and DMH.	1,2-Dimethylhydrazine	223-226	cholecystokinin	Rattus norvegicus	86-89
18248910-8	2008	Together, these data suggest that DMH CCK plays an important role in the control of food intake, and does so by activating different pathways from those activated by peripheral CCK.	1,2-Dimethylhydrazine	34-37	cholecystokinin	Rattus norvegicus	38-41
18248910-8	2008	Together, these data suggest that DMH CCK plays an important role in the control of food intake, and does so by activating different pathways from those activated by peripheral CCK.	1,2-Dimethylhydrazine	34-37	cholecystokinin	Rattus norvegicus	177-180
18361741-8	2008	We conclude that the combination of FOS and soy isoflavones inhibits colonic ACF formation and reduces COX-2 expression in DMH-treated rats.	1,2-Dimethylhydrazine	123-126	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	103-108
18037152-3	2008	Hence, in the present study we aim to investigate chemopreventive effects along with probable mechanisms of action of PBP extract employing 1,2-dimethylhydrazine (DMH)-induced colorectal carcinogenesis in Sprague-Dawley rats as experimental model.	1,2-Dimethylhydrazine	140-161	phosphatidylethanolamine binding protein 1	Rattus norvegicus	118-121
18037152-3	2008	Hence, in the present study we aim to investigate chemopreventive effects along with probable mechanisms of action of PBP extract employing 1,2-dimethylhydrazine (DMH)-induced colorectal carcinogenesis in Sprague-Dawley rats as experimental model.	1,2-Dimethylhydrazine	163-166	phosphatidylethanolamine binding protein 1	Rattus norvegicus	118-121
18037152-6	2008	Mechanistically, PBP extract may inhibit colorectal carcinogenesis by decreasing DMH-induced cell proliferation via Wnt/beta-catenin pathway.	1,2-Dimethylhydrazine	81-84	phosphatidylethanolamine binding protein 1	Rattus norvegicus	17-20
18037152-8	2008	DMH-induced activation of MAP kinases such as ERK and JNK was also found to be inhibited by treatments with PBP extract.	1,2-Dimethylhydrazine	0-3	phosphatidylethanolamine binding protein 1	Rattus norvegicus	108-111
18037152-9	2008	In conclusion, the protective effects of PBP extract could be attributed to inhibition of DMH-induced cellular proliferation probably through beta-catenin regulation.	1,2-Dimethylhydrazine	90-93	phosphatidylethanolamine binding protein 1	Rattus norvegicus	41-44
17847023-0	2008	K-ras mutations and mucin profile in preneoplastic lesions and colon tumors induced in rats by 1,2-dimethylhydrazine.	1,2-Dimethylhydrazine	95-116	solute carrier family 13 member 2	Rattus norvegicus	20-25
17409266-6	2007	In situ hybridization determinations revealed that, while HFD reduced neuropeptide Y (NPY) mRNA expression in both the arcuate nucleus (Arc) and the dorsomedial hypothalamus (DMH) of LETO rats, HFD resulted in decreased NPY expression in the Arc but not in the DMH of OLETF rats.	1,2-Dimethylhydrazine	175-178	neuropeptide Y	Rattus norvegicus	86-89
18160634-10	2007	These findings demonstrate that BDNF is an integral component of central mechanisms mediating satiety in the adult mouse and, moreover, that its synthesis in the VMH and/or DMH is required for the suppression of appetite.	1,2-Dimethylhydrazine	173-176	brain derived neurotrophic factor	Mus musculus	32-36
17868752-0	2007	Inhibitory effect of phytoglycoprotein on tumor necrosis factor-alpha and interleukin-6 at initiation stage of colon cancer in 1,2-dimethylhydrazine-treated ICR mice.	1,2-Dimethylhydrazine	127-148	interleukin 6	Mus musculus	74-87
17510083-10	2007	These findings indicate that inflammation-associated regenerative mucosa with Paneth cell metaplasia and alteration in the APC/beta-catenin/Tcf signal transduction pathway are possibly involved in the acceleration of colorectal carcinogenesis in this DMH-DSS rat model.	1,2-Dimethylhydrazine	251-254	catenin beta 1	Rattus norvegicus	127-139
17927775-3	2007	Many neurons in the medial preoptic area and the dorsal area of the DMH were retrogradely labeled, and approximately half of those in the medial preoptic area and moderate numbers in the dorsal DMH were also positive for nNOS.	1,2-Dimethylhydrazine	194-197	nitric oxide synthase 1	Rattus norvegicus	221-225
17927775-5	2007	However, retrogradely labeled neurons positive for c-fos were increased only in the dorsal DMH and adjoining region in both stressed and lipopolysaccharide-treated groups, and triple-labeled neurons were found only in this area in rats subjected to either stress paradigm.	1,2-Dimethylhydrazine	91-94	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	51-56
17927775-6	2007	Thus, hypothalamic neurons that project to the rRP and express c-fos in response to either experimental stress or systemic inflammation are found only in the dorsal DMH, and many of those activated by stress contain nNOS, suggesting that nitric oxide may play a role in signaling in this pathway.	1,2-Dimethylhydrazine	165-168	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	63-68
17409266-6	2007	In situ hybridization determinations revealed that, while HFD reduced neuropeptide Y (NPY) mRNA expression in both the arcuate nucleus (Arc) and the dorsomedial hypothalamus (DMH) of LETO rats, HFD resulted in decreased NPY expression in the Arc but not in the DMH of OLETF rats.	1,2-Dimethylhydrazine	175-178	neuropeptide Y	Rattus norvegicus	220-223
17590543-6	2007	On the contrary, significantly increased levels of reduced glutathione (GSH) and glutathione reductase (GR) were observed in DMH treated rats.	1,2-Dimethylhydrazine	125-128	glutathione-disulfide reductase	Rattus norvegicus	81-102
17590543-6	2007	On the contrary, significantly increased levels of reduced glutathione (GSH) and glutathione reductase (GR) were observed in DMH treated rats.	1,2-Dimethylhydrazine	125-128	glutathione-disulfide reductase	Rattus norvegicus	104-106
17590543-7	2007	Administration of zinc to DMH treated rats significantly decreased the tumor incidence, tumor size and aberrant crypt foci number with simultaneous enhancement of lipid peroxidation, SOD, catalase and glutathione-S-transferase.	1,2-Dimethylhydrazine	26-29	catalase	Rattus norvegicus	188-196
17590543-7	2007	Administration of zinc to DMH treated rats significantly decreased the tumor incidence, tumor size and aberrant crypt foci number with simultaneous enhancement of lipid peroxidation, SOD, catalase and glutathione-S-transferase.	1,2-Dimethylhydrazine	26-29	hematopoietic prostaglandin D synthase	Rattus norvegicus	201-226
17590543-8	2007	Further, the levels of GSH and GR were also decreased following zinc supplementation to DMH treated rats.	1,2-Dimethylhydrazine	88-91	glutathione-disulfide reductase	Rattus norvegicus	31-33
17196304-4	2007	DMH NPY expression is elevated in pair-fed OLETF rats lacking cholecystokinin (CCK)-1 receptors.	1,2-Dimethylhydrazine	0-3	neuropeptide Y	Rattus norvegicus	4-7
16850523-1	2007	The aim of the present study was to unravel the chemopreventive effect of luteolin on bacterial enzymes such as beta-glucuronidase and mucinase in a colon carcinogenesis model induced by 1, 2-dimethyl hydrazine (DMH).	1,2-Dimethylhydrazine	187-210	glucuronidase, beta	Rattus norvegicus	112-130
16850523-1	2007	The aim of the present study was to unravel the chemopreventive effect of luteolin on bacterial enzymes such as beta-glucuronidase and mucinase in a colon carcinogenesis model induced by 1, 2-dimethyl hydrazine (DMH).	1,2-Dimethylhydrazine	212-215	glucuronidase, beta	Rattus norvegicus	112-130
16850523-6	2007	Colon cancer incidence and the activities of bacterial enzymes beta-glucuronidase (in the proximal colon, distal colon, intestines, liver and colon contents) and mucinase (colon and fecal contents) were significantly increased in DMH -treated rats compared to the control rats.	1,2-Dimethylhydrazine	230-233	glucuronidase, beta	Rattus norvegicus	63-81
17511351-3	2007	In DMH treated rats, 100% colon tumor incidence was accompanied by enhanced LPO and a decrease in reduced glutathione (GSH) content as well as a fall in glutathione peroxidase (GPx), glutathione S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT) activities.	1,2-Dimethylhydrazine	3-6	hematopoietic prostaglandin D synthase	Rattus norvegicus	183-208
17511351-3	2007	In DMH treated rats, 100% colon tumor incidence was accompanied by enhanced LPO and a decrease in reduced glutathione (GSH) content as well as a fall in glutathione peroxidase (GPx), glutathione S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT) activities.	1,2-Dimethylhydrazine	3-6	hematopoietic prostaglandin D synthase	Rattus norvegicus	210-213
17511351-3	2007	In DMH treated rats, 100% colon tumor incidence was accompanied by enhanced LPO and a decrease in reduced glutathione (GSH) content as well as a fall in glutathione peroxidase (GPx), glutathione S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT) activities.	1,2-Dimethylhydrazine	3-6	catalase	Rattus norvegicus	247-255
17511351-3	2007	In DMH treated rats, 100% colon tumor incidence was accompanied by enhanced LPO and a decrease in reduced glutathione (GSH) content as well as a fall in glutathione peroxidase (GPx), glutathione S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT) activities.	1,2-Dimethylhydrazine	3-6	catalase	Rattus norvegicus	257-260
17511351-4	2007	Inclusion of fenugreek seed powder in the diet of DMH treated rats reduced the colon tumor incidence to 16.6%, decreased the LPO and increased the activities of GPx, GST, SOD and CAT in the liver.	1,2-Dimethylhydrazine	50-53	hematopoietic prostaglandin D synthase	Rattus norvegicus	166-169
17511351-4	2007	Inclusion of fenugreek seed powder in the diet of DMH treated rats reduced the colon tumor incidence to 16.6%, decreased the LPO and increased the activities of GPx, GST, SOD and CAT in the liver.	1,2-Dimethylhydrazine	50-53	catalase	Rattus norvegicus	179-182
17178380-3	2007	We report herein that administration of the selective COX-2 inhibitor, celecoxib, significantly reduces the number of Gr1(+)CD11b(+) immature myeloid suppressor cells (IMSCs) during chemoprevention of 1,2-dimethylhydrazine diHCl-(1,2-DMH-) induction of large intestinal tumors in Swiss mice.	1,2-Dimethylhydrazine	230-237	prostaglandin-endoperoxide synthase 2	Mus musculus	54-59
17203232-0	2007	Intestinal MUC2 and gastric M1/MUC5AC in preneoplastic lesions induced by 1,2-dimethylhydrazine in rat: a sequential analysis.	1,2-Dimethylhydrazine	74-95	mucin 2, oligomeric mucus/gel-forming	Rattus norvegicus	11-15
17203232-0	2007	Intestinal MUC2 and gastric M1/MUC5AC in preneoplastic lesions induced by 1,2-dimethylhydrazine in rat: a sequential analysis.	1,2-Dimethylhydrazine	74-95	mucin 5AC, oligomeric mucus/gel-forming	Rattus norvegicus	31-37
17196304-5	2007	A role for CCK in controlling DMH NPY expression is demonstrated by the down-regulation of DMH NPY by parenchymal DMH CCK administration in intact rats.	1,2-Dimethylhydrazine	30-33	cholecystokinin	Rattus norvegicus	11-14
17196304-5	2007	A role for CCK in controlling DMH NPY expression is demonstrated by the down-regulation of DMH NPY by parenchymal DMH CCK administration in intact rats.	1,2-Dimethylhydrazine	30-33	neuropeptide Y	Rattus norvegicus	34-37
17196304-5	2007	A role for CCK in controlling DMH NPY expression is demonstrated by the down-regulation of DMH NPY by parenchymal DMH CCK administration in intact rats.	1,2-Dimethylhydrazine	30-33	neuropeptide Y	Rattus norvegicus	95-98
17196304-5	2007	A role for CCK in controlling DMH NPY expression is demonstrated by the down-regulation of DMH NPY by parenchymal DMH CCK administration in intact rats.	1,2-Dimethylhydrazine	91-94	cholecystokinin	Rattus norvegicus	11-14
17196304-5	2007	A role for CCK in controlling DMH NPY expression is demonstrated by the down-regulation of DMH NPY by parenchymal DMH CCK administration in intact rats.	1,2-Dimethylhydrazine	91-94	neuropeptide Y	Rattus norvegicus	34-37
17196304-5	2007	A role for CCK in controlling DMH NPY expression is demonstrated by the down-regulation of DMH NPY by parenchymal DMH CCK administration in intact rats.	1,2-Dimethylhydrazine	91-94	neuropeptide Y	Rattus norvegicus	95-98
17196304-5	2007	A role for CCK in controlling DMH NPY expression is demonstrated by the down-regulation of DMH NPY by parenchymal DMH CCK administration in intact rats.	1,2-Dimethylhydrazine	91-94	cholecystokinin	Rattus norvegicus	118-121
17196304-5	2007	A role for CCK in controlling DMH NPY expression is demonstrated by the down-regulation of DMH NPY by parenchymal DMH CCK administration in intact rats.	1,2-Dimethylhydrazine	91-94	cholecystokinin	Rattus norvegicus	11-14
17196304-5	2007	A role for CCK in controlling DMH NPY expression is demonstrated by the down-regulation of DMH NPY by parenchymal DMH CCK administration in intact rats.	1,2-Dimethylhydrazine	91-94	neuropeptide Y	Rattus norvegicus	34-37
17196304-5	2007	A role for CCK in controlling DMH NPY expression is demonstrated by the down-regulation of DMH NPY by parenchymal DMH CCK administration in intact rats.	1,2-Dimethylhydrazine	91-94	neuropeptide Y	Rattus norvegicus	95-98
17196304-5	2007	A role for CCK in controlling DMH NPY expression is demonstrated by the down-regulation of DMH NPY by parenchymal DMH CCK administration in intact rats.	1,2-Dimethylhydrazine	91-94	cholecystokinin	Rattus norvegicus	118-121
17118177-0	2006	IGF-II transgenic mice display increased aberrant colon crypt multiplicity and tumor volume after 1,2-dimethylhydrazine treatment.	1,2-Dimethylhydrazine	98-119	insulin-like growth factor 2	Mus musculus	0-6
17934920-10	2007	It may be concluded that the NSAIDs, particularly the coxib group of the drugs (COX-2 selective), are effective in chemoprevention in the DMH-induced colon carcinogenesis and membrane alterations.	1,2-Dimethylhydrazine	138-141	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	80-85
20020969-10	2007	DMH treatment induced lipid peroxidation and inhibited the activities of SOD and CAT.	1,2-Dimethylhydrazine	0-3	catalase	Rattus norvegicus	81-84
20020969-11	2007	Both the aspirin- and celecoxib-treated DMH groups showed a marked lowering of the lipid peroxide level along with a significant enhancement of CAT activity when compared with the DMH-treated group.	1,2-Dimethylhydrazine	40-43	catalase	Rattus norvegicus	144-147
20020969-11	2007	Both the aspirin- and celecoxib-treated DMH groups showed a marked lowering of the lipid peroxide level along with a significant enhancement of CAT activity when compared with the DMH-treated group.	1,2-Dimethylhydrazine	180-183	catalase	Rattus norvegicus	144-147
17118177-4	2006	DMH-treatment led initially to significantly more ACF in IGF-II transgenic than in wild-type mice.	1,2-Dimethylhydrazine	0-3	insulin-like growth factor 2	Mus musculus	57-63
16860348-0	2006	Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status.	1,2-Dimethylhydrazine	23-44	catenin beta 1	Rattus norvegicus	120-132
16860348-0	2006	Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status.	1,2-Dimethylhydrazine	23-44	catenin beta 1	Rattus norvegicus	157-169
16860348-1	2006	Tumors induced in the rat by 1,2-dimethylhydrazine (DMH) contain mutations in beta-catenin, but the spectrum of such mutations can be influenced by phytochemicals such as chlorophyllin (CHL) and indole-3-carbinol (I3C).	1,2-Dimethylhydrazine	29-50	catenin beta 1	Rattus norvegicus	78-90
16860348-1	2006	Tumors induced in the rat by 1,2-dimethylhydrazine (DMH) contain mutations in beta-catenin, but the spectrum of such mutations can be influenced by phytochemicals such as chlorophyllin (CHL) and indole-3-carbinol (I3C).	1,2-Dimethylhydrazine	52-55	catenin beta 1	Rattus norvegicus	78-90
16860348-2	2006	In the present study, we determined the mutation status of beta-catenin in more than 50 DMH-induced colon tumors and small intestine tumors, and compared this with the concomitant expression of beta-catenin mRNA using quantitative real-time RT-PCR analysis.	1,2-Dimethylhydrazine	88-91	catenin beta 1	Rattus norvegicus	59-71
16860348-7	2006	We conclude that DMH-induced mutations stabilize beta-catenin protein in tumors, which increase c-myc, c-jun and cyclin D1, but there also can be over-expression of beta-catenin itself at the mRNA level, contributing to high beta-catenin protein levels.	1,2-Dimethylhydrazine	17-20	catenin beta 1	Rattus norvegicus	49-61
16860348-7	2006	We conclude that DMH-induced mutations stabilize beta-catenin protein in tumors, which increase c-myc, c-jun and cyclin D1, but there also can be over-expression of beta-catenin itself at the mRNA level, contributing to high beta-catenin protein levels.	1,2-Dimethylhydrazine	17-20	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	96-101
16860348-7	2006	We conclude that DMH-induced mutations stabilize beta-catenin protein in tumors, which increase c-myc, c-jun and cyclin D1, but there also can be over-expression of beta-catenin itself at the mRNA level, contributing to high beta-catenin protein levels.	1,2-Dimethylhydrazine	17-20	cyclin D1	Rattus norvegicus	113-122
16860348-7	2006	We conclude that DMH-induced mutations stabilize beta-catenin protein in tumors, which increase c-myc, c-jun and cyclin D1, but there also can be over-expression of beta-catenin itself at the mRNA level, contributing to high beta-catenin protein levels.	1,2-Dimethylhydrazine	17-20	catenin beta 1	Rattus norvegicus	165-177
16860348-7	2006	We conclude that DMH-induced mutations stabilize beta-catenin protein in tumors, which increase c-myc, c-jun and cyclin D1, but there also can be over-expression of beta-catenin itself at the mRNA level, contributing to high beta-catenin protein levels.	1,2-Dimethylhydrazine	17-20	catenin beta 1	Rattus norvegicus	165-177
16912565-10	2006	The activities of bacterial enzymes beta-glucuronidase (proximal colon, distal colon, intestines, liver and colon contents) and mucinase (colon and fecal contents) were significantly elevated in 1,2-dimethylhydrazine-treated rats as compared with the control rats.	1,2-Dimethylhydrazine	195-216	glucuronidase, beta	Rattus norvegicus	36-54
16912565-12	2006	Ginger administration to 1,2-dimethylhydrazine-treated rats significantly decreased the incidence and number of tumors as well as the activity of beta-glucuronidase and mucinase.	1,2-Dimethylhydrazine	25-46	glucuronidase, beta	Rattus norvegicus	146-164
16912565-13	2006	Thus, ginger has a chemopreventive and anticarcinogenic effect against 1,2-dimethylhydrazine-induced colon cancer by virtue of its ability to lower the activities of the microbial enzymes beta-glucuronidase and mucinase.	1,2-Dimethylhydrazine	71-92	glucuronidase, beta	Rattus norvegicus	188-206
16807338-5	2006	Using double immunocytochemistry, we found that rats exhibiting panic-like responses (e.g., L-AG plus lactate) had increased c-Fos immunoreactivity in DMH neurons expressing the NMDA receptor 1 (NR1) subunit, but not those expressing the glutamate receptor 2 and 3 subunits of the AMPA receptors.	1,2-Dimethylhydrazine	151-154	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	125-130
17128412-2	2007	In order to establish the role of anti apoptotic proteins in colon cancer development, we studied with immunohistochemical techniques the expression of Survivin in a mouse model of colon carcinogenesis induced by 1,2-dimethyl-hydrazine treatment.	1,2-Dimethylhydrazine	213-235	baculoviral IAP repeat-containing 5	Mus musculus	152-160
16957077-4	2006	In the present study, previous injections of the angiotensin-II (A-II) type 1 receptor antagonist losartan and the nonspecific A-II receptor antagonist saralasin into the DMH of "panic-prone" rats blocked the anxiety-like and physiological components of lactate-induced panic-like responses.	1,2-Dimethylhydrazine	171-174	angiotensinogen	Rattus norvegicus	49-63
16957077-5	2006	In addition, direct injections of A-II into the DMH of these panic-prone rats also elicited panic-like responses that were blocked by pretreatment with saralasin.	1,2-Dimethylhydrazine	48-51	angiotensinogen	Rattus norvegicus	34-38
16957077-7	2006	The presence of the A-II type 1 receptors in the region of the DMH was demonstrated using immunohistochemistry.	1,2-Dimethylhydrazine	63-66	angiotensinogen	Rattus norvegicus	20-24
16928864-8	2006	OCT3-like immunoreactivity was observed in ependymal and glial-like cells in the DMH.	1,2-Dimethylhydrazine	81-84	solute carrier family 22 member 8	Rattus norvegicus	0-4
16928864-12	2006	These data support the hypothesis that corticosterone-induced inhibition of OCT3 mediates stress-induced accumulation of 5-HT in the DMH and suggest that corticosterone may acutely modulate physiological and behavioral responses to stressors by altering serotonergic neurotransmission in this brain region.	1,2-Dimethylhydrazine	133-136	solute carrier family 22 member 8	Rattus norvegicus	76-80
16733082-6	2006	Unsupplemented DMH exposed rats showed significantly decreased levels/activities of tissue DC, LOOHs, TBARS, SOD, CAT, GSH, GR and significantly elevated (P&lt;0.05) GPX, GST, alpha-tocopherol and ascorbate as compared to control rats.	1,2-Dimethylhydrazine	15-18	catalase	Rattus norvegicus	114-117
16815799-15	2006	Elevated DMH NPY in OLETF rats appears to be a consequence of the absence of CCK-1 receptors.	1,2-Dimethylhydrazine	9-12	neuropeptide Y	Rattus norvegicus	13-16
16815799-16	2006	In intact rats NPY and CCK-1 receptors colocalize to neurons within the compact subregion of the DMH and local CCK administration reduces food intake and decreases DMH NPY mRNA expression.	1,2-Dimethylhydrazine	97-100	neuropeptide Y	Rattus norvegicus	15-18
16815799-16	2006	In intact rats NPY and CCK-1 receptors colocalize to neurons within the compact subregion of the DMH and local CCK administration reduces food intake and decreases DMH NPY mRNA expression.	1,2-Dimethylhydrazine	97-100	cholecystokinin	Rattus norvegicus	23-26
16815799-20	2006	Exercise also prevents elevated levels of DMH NPY mRNA expression, suggesting that exercise exerts an alternative, non-CCK mediated, control on DMH NPY.	1,2-Dimethylhydrazine	144-147	neuropeptide Y	Rattus norvegicus	148-151
16807338-5	2006	Using double immunocytochemistry, we found that rats exhibiting panic-like responses (e.g., L-AG plus lactate) had increased c-Fos immunoreactivity in DMH neurons expressing the NMDA receptor 1 (NR1) subunit, but not those expressing the glutamate receptor 2 and 3 subunits of the AMPA receptors.	1,2-Dimethylhydrazine	151-154	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	178-193
16807338-5	2006	Using double immunocytochemistry, we found that rats exhibiting panic-like responses (e.g., L-AG plus lactate) had increased c-Fos immunoreactivity in DMH neurons expressing the NMDA receptor 1 (NR1) subunit, but not those expressing the glutamate receptor 2 and 3 subunits of the AMPA receptors.	1,2-Dimethylhydrazine	151-154	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	195-198
16403642-1	2006	Results from a factor analysis and activity studies of commercially available endocannabinoid-type compounds set the starting point for the current study where dimethylheptyl (DMH) analogues of two endocannabinoids, 2-arachidonoyl glycerol (2-AG) and 2-arachidonyl glyceryl ether (2-AGE), were synthesized and their ability to activate the CB1 receptors was determined by the [35S]GTPgammaS binding assay using rat cerebellar membranes.	1,2-Dimethylhydrazine	176-179	cannabinoid receptor 1	Rattus norvegicus	340-343
16338953-11	2006	Oxidative imbalance in DMH-treatment was significantly (P &lt; 0.01) modulated on Res supplementation as indicated by optimal concentration of thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH).	1,2-Dimethylhydrazine	23-26	catalase	Rattus norvegicus	220-228
16338953-11	2006	Oxidative imbalance in DMH-treatment was significantly (P &lt; 0.01) modulated on Res supplementation as indicated by optimal concentration of thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH).	1,2-Dimethylhydrazine	23-26	catalase	Rattus norvegicus	230-233
16579724-10	2006	These results indicate that Bcl-2 family protein levels are associated with CLA-induced apoptosis in the colonic mucosa of DMH-treated rats.	1,2-Dimethylhydrazine	123-126	BCL2, apoptosis regulator	Rattus norvegicus	28-33
16761624-0	2006	Distribution of preneoplastic lesions and tumors, and beta-catenin gene mutations in colon carcinomas induced by 1,2-dimethylhydrazine plus dextran sulfate sodium.	1,2-Dimethylhydrazine	113-134	catenin beta 1	Rattus norvegicus	54-66
16619498-0	2006	PSC 833, an inhibitor of P-glycoprotein inhibits 1,2-dimethylhydrazine-induced colorectal carcinogenesis in male Fischer F344 rats.	1,2-Dimethylhydrazine	49-70	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	25-39
15802299-8	2005	However, CloA but not CleA prevented the DMH-induced reduction of splenocyte CD4/CD8 (T-helper cells to cytotoxic lymphocytes) ratio.	1,2-Dimethylhydrazine	41-44	Cd4 molecule	Rattus norvegicus	77-80
16702625-4	2006	Intragastric administration of BDMCA or curcumin to DMH-treated rats significantly decreased colon tumor incidence and the circulatory LPO, with simultaneous enhancement of GSH content and GPx, GST, SOD and CAT activities.	1,2-Dimethylhydrazine	52-55	catalase	Rattus norvegicus	207-210
16317136-3	2005	The number of colorectal aberrant crypt foci (ACF), putative preneoplastic lesions induced by 1,2-dimethylhydrazine, was reduced after MDT-1 administration (10(9) cfu/dose, 3 times/wk for 4 wk).	1,2-Dimethylhydrazine	94-115	retinol dehydrogenase 11	Mus musculus	135-140
16208626-6	2005	In experiment II, the induction of glutathione S-transferase placental form (GST-P) positive foci by 1,2-dimethylhydrazine (DMH) was evaluated in a modified in vivo 5-week initiation assay model.	1,2-Dimethylhydrazine	101-122	glutathione S-transferase pi 1	Rattus norvegicus	35-82
16208626-6	2005	In experiment II, the induction of glutathione S-transferase placental form (GST-P) positive foci by 1,2-dimethylhydrazine (DMH) was evaluated in a modified in vivo 5-week initiation assay model.	1,2-Dimethylhydrazine	124-127	glutathione S-transferase pi 1	Rattus norvegicus	35-82
16208626-10	2005	Induction of GST-P positive foci in the group given DMH at 84 hours after a single administration of d-gal was significantly greater than in the control group, correlating with the kinetics of cell proliferation.	1,2-Dimethylhydrazine	52-55	glutathione S-transferase pi 1	Rattus norvegicus	13-18
16266234-4	2005	The purpose of this study was to determine whether the systemic administration of IL-12 (+/- IL-2) may induce an immune response against CRC as induced by 1,2-dimethylhydrazine (DMH).	1,2-Dimethylhydrazine	155-176	interleukin 12B	Rattus norvegicus	82-87
16266234-4	2005	The purpose of this study was to determine whether the systemic administration of IL-12 (+/- IL-2) may induce an immune response against CRC as induced by 1,2-dimethylhydrazine (DMH).	1,2-Dimethylhydrazine	155-176	interleukin 2	Rattus norvegicus	93-97
16266234-4	2005	The purpose of this study was to determine whether the systemic administration of IL-12 (+/- IL-2) may induce an immune response against CRC as induced by 1,2-dimethylhydrazine (DMH).	1,2-Dimethylhydrazine	178-181	interleukin 12B	Rattus norvegicus	82-87
16266234-4	2005	The purpose of this study was to determine whether the systemic administration of IL-12 (+/- IL-2) may induce an immune response against CRC as induced by 1,2-dimethylhydrazine (DMH).	1,2-Dimethylhydrazine	178-181	interleukin 2	Rattus norvegicus	93-97
16210915-9	2005	The median survival after DMH injections was significantly shorter for the Cables-/- mice compared to Cables+/+ littermates.	1,2-Dimethylhydrazine	26-29	CDK5 and Abl enzyme substrate 1	Mus musculus	75-81
15665488-0	2005	Y-700, a novel inhibitor of xanthine oxidase, suppresses the development of colon aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine-treated mice.	1,2-Dimethylhydrazine	128-149	xanthine dehydrogenase	Mus musculus	28-44
15696191-0	2005	Decreased susceptibility of mast cell-deficient Kit(W)/Kit(W-v) mice to the development of 1, 2-dimethylhydrazine-induced intestinal tumors.	1,2-Dimethylhydrazine	91-113	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	48-51
15696191-0	2005	Decreased susceptibility of mast cell-deficient Kit(W)/Kit(W-v) mice to the development of 1, 2-dimethylhydrazine-induced intestinal tumors.	1,2-Dimethylhydrazine	91-113	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	55-58
15696191-9	2005	These results show that genetic impairment of c-kit function reduces the susceptibility of mice to DMH-induced colonic tumors, and that defects in bone marrow-derived cells in the W/W(v) mice contribute significantly to this result.	1,2-Dimethylhydrazine	99-102	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	46-51
15723650-0	2005	Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate.	1,2-Dimethylhydrazine	96-117	catenin (cadherin associated protein), beta 1	Mus musculus	0-12
15723650-8	2005	Immunohistochemical investigation revealed that adnocarcinomas, induced by DMH at all doses and 2%DSS, showed positive reactivities against beta-catenin, COX-2 and iNOS.	1,2-Dimethylhydrazine	75-78	catenin (cadherin associated protein), beta 1	Mus musculus	140-152
15723650-8	2005	Immunohistochemical investigation revealed that adnocarcinomas, induced by DMH at all doses and 2%DSS, showed positive reactivities against beta-catenin, COX-2 and iNOS.	1,2-Dimethylhydrazine	75-78	cytochrome c oxidase II, mitochondrial	Mus musculus	154-159
15723650-8	2005	Immunohistochemical investigation revealed that adnocarcinomas, induced by DMH at all doses and 2%DSS, showed positive reactivities against beta-catenin, COX-2 and iNOS.	1,2-Dimethylhydrazine	75-78	nitric oxide synthase 2, inducible	Mus musculus	164-168
15723650-9	2005	In DMH/DSS-induced adenocarcinomas, 10 of 11 (90.9%) adenocacrcinomas had beta-catenin gene mutations.	1,2-Dimethylhydrazine	3-6	catenin (cadherin associated protein), beta 1	Mus musculus	74-86
15175378-2	2004	Using lactating rats as a model, the present study first showed that in the DMH abundant alpha-MSH and agouti-related protein fibers are in close apposition to NPY-positive cells.	1,2-Dimethylhydrazine	76-79	agouti related neuropeptide	Rattus norvegicus	103-125
16210868-7	2005	However, in the dorsal medial hypothalamus (DMH), a region associated with regulation of food intake, both ghrelin and BIM-28163 act as agonists to upregulate Fos-IR.	1,2-Dimethylhydrazine	44-47	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	159-162
20021056-5	2005	The colon and intestine administered DMH showed a decrease in lipid peroxidation with a concomitant increase in the activities of GSH-dependent enzymes (glutathione peroxidase, glutathione S-transferase) when compared to untreated control rats.	1,2-Dimethylhydrazine	37-40	hematopoietic prostaglandin D synthase	Rattus norvegicus	177-202
15525283-7	2004	In contrast, rats that had received muscimol injections into their mPFC and were subsequently restrained exhibited an increase in the number of Fos-positive cells in the DMH, medial amygdala, and medial nucleus tractus solitarius as compared to vehicle-injected rats that experienced restraint stress.	1,2-Dimethylhydrazine	170-173	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	144-147
15123537-8	2004	Furthermore, in intact rats, NPY and CCK-AR are colocalized in DMH neurons, and parenchymal injection of CCK into the DMH reduces food intake and down-regulates DMH NPY mRNA expression.	1,2-Dimethylhydrazine	63-66	neuropeptide Y	Rattus norvegicus	29-32
15123537-8	2004	Furthermore, in intact rats, NPY and CCK-AR are colocalized in DMH neurons, and parenchymal injection of CCK into the DMH reduces food intake and down-regulates DMH NPY mRNA expression.	1,2-Dimethylhydrazine	63-66	cholecystokinin A receptor	Rattus norvegicus	37-43
15123537-8	2004	Furthermore, in intact rats, NPY and CCK-AR are colocalized in DMH neurons, and parenchymal injection of CCK into the DMH reduces food intake and down-regulates DMH NPY mRNA expression.	1,2-Dimethylhydrazine	63-66	cholecystokinin	Rattus norvegicus	37-40
15123537-8	2004	Furthermore, in intact rats, NPY and CCK-AR are colocalized in DMH neurons, and parenchymal injection of CCK into the DMH reduces food intake and down-regulates DMH NPY mRNA expression.	1,2-Dimethylhydrazine	118-121	neuropeptide Y	Rattus norvegicus	165-168
15123537-9	2004	These results suggest that although CCK-AR plays a role in the mediation of CCK actions in the control of meal size in both rats and mice, CCK-AR seems to contribute to modulating DMH NPY levels only in rats.	1,2-Dimethylhydrazine	180-183	cholecystokinin A receptor	Mus musculus	139-145
15175378-1	2004	In several hyperphagic models, including lactation, in which hypothalamic melanocortin signaling is reduced, a novel expression of NPY mRNA in the dorsomedial hypothalamus (DMH) has been observed, suggesting that melanocortin signaling and the induced NPY in the DMH may constitute unique neurocircuitry in mediating energy balance.	1,2-Dimethylhydrazine	173-176	neuropeptide Y	Rattus norvegicus	131-134
15175378-1	2004	In several hyperphagic models, including lactation, in which hypothalamic melanocortin signaling is reduced, a novel expression of NPY mRNA in the dorsomedial hypothalamus (DMH) has been observed, suggesting that melanocortin signaling and the induced NPY in the DMH may constitute unique neurocircuitry in mediating energy balance.	1,2-Dimethylhydrazine	173-176	neuropeptide Y	Rattus norvegicus	252-255
15175378-2	2004	Using lactating rats as a model, the present study first showed that in the DMH abundant alpha-MSH and agouti-related protein fibers are in close apposition to NPY-positive cells.	1,2-Dimethylhydrazine	76-79	proopiomelanocortin	Rattus norvegicus	89-98
15175378-2	2004	Using lactating rats as a model, the present study first showed that in the DMH abundant alpha-MSH and agouti-related protein fibers are in close apposition to NPY-positive cells.	1,2-Dimethylhydrazine	76-79	neuropeptide Y	Rattus norvegicus	160-163
15175378-7	2004	Furthermore, MTII treatment greatly attenuated suckling-induced NPY expression in the DMH.	1,2-Dimethylhydrazine	86-89	neuropeptide Y	Rattus norvegicus	64-67
15175378-9	2004	In summary, the present study demonstrated that the melanocortin system in the DMH not only plays an important role in inducing NPY expression in the DMH of lactating rats but also in regulating energy homeostasis, at least in part, by modulating appetite and energy expenditure.	1,2-Dimethylhydrazine	79-82	neuropeptide Y	Rattus norvegicus	128-131
12967719-11	2003	Furthermore, as suggested by studies in intact rats, neurons in the DMH, including those projecting to the PVN, are regulated by tonic GABA(A) and non-NMDA glutamate receptor-mediated synaptic transmission.	1,2-Dimethylhydrazine	68-71	glutamate ionotropic receptor NMDA type subunit 2C	Rattus norvegicus	151-174
15026282-8	2004	DMH injections significantly elevated both the activities of beta-glucuronidase (distal colon, distal intestine, liver and colon contents) and mucinase (colon and fecal contents) as compared to the control rats.	1,2-Dimethylhydrazine	0-3	glucuronidase, beta	Rattus norvegicus	61-79
15026282-10	2004	Coconut cake supplementation to DMH-treated rats significantly decreased the incidence and number of tumors as well as the activity of beta-glucuronidase and mucinase.	1,2-Dimethylhydrazine	32-35	glucuronidase, beta	Rattus norvegicus	135-153
15026282-11	2004	CONCLUSIONS: Coconut cake has a protective effect against DMH induced colon cancer by virtue of its ability to lower the activities of the microbial enzymes beta-glucuronidase and mucinase.	1,2-Dimethylhydrazine	58-61	glucuronidase, beta	Rattus norvegicus	157-175
15039638-11	2004	IL-4 and apoptotic cells increased in the yogurt-DMH group only in the first months.	1,2-Dimethylhydrazine	49-52	interleukin 4	Mus musculus	0-4
15278915-6	2004	Analysis of antioxidant defense enzyme activity in colonic mucosa indicated that glutathione reductase and catalase activities were increased in 1,2-DMH-treated rats; cotreatment with vanadium reduced these activities when compared to the carcinogen control (P &lt; 0.001 and P &lt; 0.02).	1,2-Dimethylhydrazine	145-152	glutathione-disulfide reductase	Rattus norvegicus	81-102
15278915-6	2004	Analysis of antioxidant defense enzyme activity in colonic mucosa indicated that glutathione reductase and catalase activities were increased in 1,2-DMH-treated rats; cotreatment with vanadium reduced these activities when compared to the carcinogen control (P &lt; 0.001 and P &lt; 0.02).	1,2-Dimethylhydrazine	145-152	catalase	Rattus norvegicus	107-115
15203375-9	2004	Moreover, when treated with DMH, HFD rats exhibited a dramatically decreased expression of RXRalpha mRNA (-49%).	1,2-Dimethylhydrazine	28-31	retinoid X receptor alpha	Rattus norvegicus	91-99
14643021-2	2003	The present experiment was designed to assess the potential chemopreventive properties of JTE-522, a new selective cyclooxygenase-2 inhibitor, on the induction of 1,2-dimethylhydrazine (DMH)-induced colonic aberrant crypt foci (ACF), a marker of rat colon carcinogenesis.	1,2-Dimethylhydrazine	163-184	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	115-131
14643021-2	2003	The present experiment was designed to assess the potential chemopreventive properties of JTE-522, a new selective cyclooxygenase-2 inhibitor, on the induction of 1,2-dimethylhydrazine (DMH)-induced colonic aberrant crypt foci (ACF), a marker of rat colon carcinogenesis.	1,2-Dimethylhydrazine	186-189	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	115-131
14622096-5	2003	In addition, NMU mRNA levels were elevated in the DMH of mice fasted for 24 h relative to ad libitum fed controls.	1,2-Dimethylhydrazine	50-53	neuromedin U	Mus musculus	13-16
12842868-9	2003	DMH NPY-expressing neurons do not appear to be under the direct control of leptin signaling.	1,2-Dimethylhydrazine	0-3	neuropeptide Y	Rattus norvegicus	4-7
14595593-1	2003	The effect of fenugreek seeds on the activities of beta-glucuronidase and mucinase during 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in rats was studied.	1,2-Dimethylhydrazine	90-111	glucuronidase, beta	Rattus norvegicus	51-69
14595593-4	2003	After an experimental period of 30 weeks the activity of beta-glucuronidase significantly increased in the colon, intestine, liver and colon contents in DMH administered rats when compared to an untreated control group.	1,2-Dimethylhydrazine	153-156	glucuronidase, beta	Rattus norvegicus	57-75
12669311-2	2003	We recently reported that 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)- and 1,2-dimethylhydrazine (DMH)-induced colon tumors in the rat contain mutations in Ctnnb1, the gene for beta-catenin, but the mutation spectrum was influenced by postinitiation exposure to chlorophyllin (CHL) and indole-3-carbinol (I3C) [Blum et al., Carcinogenesis 2001;22:315-320].	1,2-Dimethylhydrazine	76-97	catenin beta 1	Rattus norvegicus	157-163
12743811-0	2003	High susceptibility of nullizygous p53 knockout mice to colorectal tumor induction by 1,2-dimethylhydrazine.	1,2-Dimethylhydrazine	86-107	transformation related protein 53, pseudogene	Mus musculus	35-38
12743811-8	2003	CONCLUSIONS: These results suggest that p53 might not be a direct target of DMH but complete loss of p53 might elevate susceptibility to DMH-induced colorectal carcinogenesis.	1,2-Dimethylhydrazine	137-140	transformation related protein 53, pseudogene	Mus musculus	101-104
12631353-11	2003	The mean expression of p27 decreased significantly in order from normal (100%), MCD (45.9%), DMH (22.4%), and FSGS (16.7%), and the difference between MCD and FSGS was significant.	1,2-Dimethylhydrazine	93-96	interferon alpha inducible protein 27	Homo sapiens	23-26
12631353-12	2003	p21 was significantly and equally reduced in MCD (2.3%), DMH (0%), and FSGS (0.7%) compared to normal (66.6%).	1,2-Dimethylhydrazine	57-60	H3 histone pseudogene 16	Homo sapiens	0-3
12669311-2	2003	We recently reported that 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)- and 1,2-dimethylhydrazine (DMH)-induced colon tumors in the rat contain mutations in Ctnnb1, the gene for beta-catenin, but the mutation spectrum was influenced by postinitiation exposure to chlorophyllin (CHL) and indole-3-carbinol (I3C) [Blum et al., Carcinogenesis 2001;22:315-320].	1,2-Dimethylhydrazine	76-97	catenin beta 1	Rattus norvegicus	178-190
12669311-2	2003	We recently reported that 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)- and 1,2-dimethylhydrazine (DMH)-induced colon tumors in the rat contain mutations in Ctnnb1, the gene for beta-catenin, but the mutation spectrum was influenced by postinitiation exposure to chlorophyllin (CHL) and indole-3-carbinol (I3C) [Blum et al., Carcinogenesis 2001;22:315-320].	1,2-Dimethylhydrazine	99-102	catenin beta 1	Rattus norvegicus	157-163
12669311-2	2003	We recently reported that 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)- and 1,2-dimethylhydrazine (DMH)-induced colon tumors in the rat contain mutations in Ctnnb1, the gene for beta-catenin, but the mutation spectrum was influenced by postinitiation exposure to chlorophyllin (CHL) and indole-3-carbinol (I3C) [Blum et al., Carcinogenesis 2001;22:315-320].	1,2-Dimethylhydrazine	99-102	catenin beta 1	Rattus norvegicus	178-190
12628520-1	2003	The carcinogens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 1,2-dimethylhydrazine (DMH) induce colon tumors in the rat that contain mutations in beta-catenin, but the mutation pattern can be influenced by exposure to dietary phytochemicals, such as the water-soluble derivative of chlorophyll called chlorophyllin.	1,2-Dimethylhydrazine	65-86	catenin beta 1	Rattus norvegicus	150-162
12618326-3	2003	Liver gamma-glutamyl transpeptidase, which was elevated to 0.41 +/- 0.06 nmol/mg protein by DMH administration was found to be reduced to 0.22 +/- 0.04 and 0.18 +/- 0.03 nmol/mg protein by Picroliv treatment 40 and 200 mg/kg, respectively.	1,2-Dimethylhydrazine	92-95	gamma-glutamyltransferase 1	Rattus norvegicus	6-35
12618326-5	2003	DMH-induced depletion of hepatic and renal antioxidant enzymes such as catalase and superoxide dismutase levels were restored to normal by Picroliv treatment.	1,2-Dimethylhydrazine	0-3	catalase	Rattus norvegicus	71-79
12618326-8	2003	Depleted renal glutathione S-transferase and hepatic glutathione levels after DMH administered rats were found to be significantly increased by Picroliv treatment.	1,2-Dimethylhydrazine	78-81	hematopoietic prostaglandin D synthase	Rattus norvegicus	15-40
12543061-9	2003	In DMH-induced tumor bearing rats the levels of colonic and intestinal cholesterol was significantly increased whereas, the levels of phospholipid was decreased with a concomitant increase in the activities of phospholipase A (PLA) and phospholipase C (PLC), compared to untreated control rats.	1,2-Dimethylhydrazine	3-6	phospholipase A and acyltransferase 1	Rattus norvegicus	210-225
12543061-9	2003	In DMH-induced tumor bearing rats the levels of colonic and intestinal cholesterol was significantly increased whereas, the levels of phospholipid was decreased with a concomitant increase in the activities of phospholipase A (PLA) and phospholipase C (PLC), compared to untreated control rats.	1,2-Dimethylhydrazine	3-6	phospholipase A and acyltransferase 1	Rattus norvegicus	227-230
12543061-10	2003	Intragastric administration of BDMC-A and curcumin to DMH administered rats significantly lowered the cholesterol content and raised the phospholipid content and lowered the activities of PLA and PLC towards near normal values.	1,2-Dimethylhydrazine	54-57	phospholipase A and acyltransferase 1	Rattus norvegicus	188-191
12628520-1	2003	The carcinogens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 1,2-dimethylhydrazine (DMH) induce colon tumors in the rat that contain mutations in beta-catenin, but the mutation pattern can be influenced by exposure to dietary phytochemicals, such as the water-soluble derivative of chlorophyll called chlorophyllin.	1,2-Dimethylhydrazine	88-91	catenin beta 1	Rattus norvegicus	150-162
12628520-5	2003	Molecular studies showed that the spectrum of beta-catenin mutations was markedly different in chlorophyllin-promoted colon tumors--many of the mutations led to direct substitutions of critical Ser/Thr residues within the glycogen synthase kinase-3beta (GSK-3beta) region, whereas in all other groups, including DMH and IQ controls, the mutations typically affected amino acids adjacent to Ser(33).	1,2-Dimethylhydrazine	312-315	catenin beta 1	Rattus norvegicus	46-58
11794536-4	2001	The fecal beta-glucuronidase activity of human intestinal bacteria was drastically induced by its substrate or the bile secreted after a subcutaneous injection of 1,2-dimethylhydrazine (DMH) and benzo[a]pyrene into rats.	1,2-Dimethylhydrazine	163-184	glucuronidase beta	Homo sapiens	10-28
12756972-14	2003	In summary, alterations in the beta-catenin expression and cellular localisation in the DMH-induced tumours are similar to those seen inhuman sporadic colorectal tumours.	1,2-Dimethylhydrazine	88-91	catenin (cadherin associated protein), beta 1	Mus musculus	31-43
12756972-15	2003	The DMH is therefore a useful model for studying the abnormalities of the E-cadherin-catenin pathway in colorectal carcinogenesis.	1,2-Dimethylhydrazine	4-7	cadherin 1	Mus musculus	74-84
12160894-3	2002	In particular, a potent colon carcinogen, 1,2-dimethyl hydrazine (SDMH), was not detected as a mutagen by a standard Ames test, but was able to induce RNR3-lacZ expression.	1,2-Dimethylhydrazine	42-64	ribonucleotide-diphosphate reductase subunit RNR3	Saccharomyces cerevisiae S288C	151-155
12160894-3	2002	In particular, a potent colon carcinogen, 1,2-dimethyl hydrazine (SDMH), was not detected as a mutagen by a standard Ames test, but was able to induce RNR3-lacZ expression.	1,2-Dimethylhydrazine	66-70	ribonucleotide-diphosphate reductase subunit RNR3	Saccharomyces cerevisiae S288C	151-155
12086850-4	2002	p27 expression was frequently reduced in GI tumors arising in 1,2-dimethylhydrazine (DMH) treated mice, and in Apc mutant Min/+ mice, but not in GI tumors arising in Smad3 mutant mice.	1,2-Dimethylhydrazine	62-83	cyclin-dependent kinase inhibitor 1B	Mus musculus	0-3
12086850-4	2002	p27 expression was frequently reduced in GI tumors arising in 1,2-dimethylhydrazine (DMH) treated mice, and in Apc mutant Min/+ mice, but not in GI tumors arising in Smad3 mutant mice.	1,2-Dimethylhydrazine	85-88	cyclin-dependent kinase inhibitor 1B	Mus musculus	0-3
12086850-5	2002	Germline deletion of p27 resulted in accelerated tumor development and increased tumor cell proliferation in both DMH treated and Min/+ mice, but not in Smad3 mutant mice.	1,2-Dimethylhydrazine	114-117	cyclin-dependent kinase inhibitor 1B	Mus musculus	21-24
14708091-0	2003	Vanadium inhibits placental glutathione S-transferase (GST-P) positive foci in 1,2-dimethyl hydrazine induced rat colon carcinogenesis.	1,2-Dimethylhydrazine	79-101	hematopoietic prostaglandin D synthase	Rattus norvegicus	28-53
14708091-0	2003	Vanadium inhibits placental glutathione S-transferase (GST-P) positive foci in 1,2-dimethyl hydrazine induced rat colon carcinogenesis.	1,2-Dimethylhydrazine	79-101	glutathione S-transferase pi 1	Rattus norvegicus	55-60
14708091-2	2003	In the present study attempts have been made to investigate the expression of the number and area of aberrant crypt foci positive for placental glutathione S-transferase (GST-P) during 1,2-dimethyl hydrazine (DMH)-induced rat colon carcinogenesis.	1,2-Dimethylhydrazine	185-207	hematopoietic prostaglandin D synthase	Rattus norvegicus	144-169
14708091-2	2003	In the present study attempts have been made to investigate the expression of the number and area of aberrant crypt foci positive for placental glutathione S-transferase (GST-P) during 1,2-dimethyl hydrazine (DMH)-induced rat colon carcinogenesis.	1,2-Dimethylhydrazine	185-207	glutathione S-transferase pi 1	Rattus norvegicus	171-176
14708091-2	2003	In the present study attempts have been made to investigate the expression of the number and area of aberrant crypt foci positive for placental glutathione S-transferase (GST-P) during 1,2-dimethyl hydrazine (DMH)-induced rat colon carcinogenesis.	1,2-Dimethylhydrazine	209-212	hematopoietic prostaglandin D synthase	Rattus norvegicus	144-169
14708091-2	2003	In the present study attempts have been made to investigate the expression of the number and area of aberrant crypt foci positive for placental glutathione S-transferase (GST-P) during 1,2-dimethyl hydrazine (DMH)-induced rat colon carcinogenesis.	1,2-Dimethylhydrazine	209-212	glutathione S-transferase pi 1	Rattus norvegicus	171-176
14708091-9	2003	The expression of the number and the area of aberrant crypt foci (ACF) positive for GST-P was maximum in DMH-treated group.	1,2-Dimethylhydrazine	105-108	glutathione S-transferase pi 1	Rattus norvegicus	84-89
12036908-0	2002	p53 transgenic mice are highly susceptible to 1, 2-dimethylhydrazine-induced uterine sarcomas.	1,2-Dimethylhydrazine	46-68	transformation related protein 53, pseudogene	Mus musculus	0-3
12036908-3	2002	The presence of a mutant p53 led to an increased incidence or multiplicity of uterine sarcomas, colon carcinomas, lung adenomas, and hepatomas in DMH-treated mice.	1,2-Dimethylhydrazine	146-149	transformation related protein 53, pseudogene	Mus musculus	25-28
12036908-6	2002	In DMH-treated animals, long-term treatment with this chemopreventive agent, piroxicam, reduced colon carcinoma incidence and multiplicity in both p53(val135/wt) or p53(wt/wt) mice but did not affect the formation of uterine sarcomas, lung adenomas, or hepatomas.	1,2-Dimethylhydrazine	3-6	transformation related protein 53, pseudogene	Mus musculus	147-150
12036908-6	2002	In DMH-treated animals, long-term treatment with this chemopreventive agent, piroxicam, reduced colon carcinoma incidence and multiplicity in both p53(val135/wt) or p53(wt/wt) mice but did not affect the formation of uterine sarcomas, lung adenomas, or hepatomas.	1,2-Dimethylhydrazine	3-6	transformation related protein 53, pseudogene	Mus musculus	165-168
11893629-6	2002	Neuropeptide Y (NPY) was increased by lactation in both the ARC and dorsomedial hypothalamus (DMH), although increased gene expression in the DMH was only apparent at day 18 of lactation.	1,2-Dimethylhydrazine	94-97	pro-neuropeptide Y	Ovis aries	0-14
11893629-6	2002	Neuropeptide Y (NPY) was increased by lactation in both the ARC and dorsomedial hypothalamus (DMH), although increased gene expression in the DMH was only apparent at day 18 of lactation.	1,2-Dimethylhydrazine	94-97	pro-neuropeptide Y	Ovis aries	16-19
11790447-9	2002	II, the numbers of GST-P-positive foci in the groups treated with DMH plus DHPN or DMH plus DEN were significantly higher than those in the groups receiving the carcinogens singly.	1,2-Dimethylhydrazine	66-69	glutathione S-transferase pi 1	Rattus norvegicus	19-24
11794536-4	2001	The fecal beta-glucuronidase activity of human intestinal bacteria was drastically induced by its substrate or the bile secreted after a subcutaneous injection of 1,2-dimethylhydrazine (DMH) and benzo[a]pyrene into rats.	1,2-Dimethylhydrazine	186-189	glucuronidase beta	Homo sapiens	10-28
11794536-5	2001	DMH- and benzo[a]pyrene-treated biles induced beta-glucuronidase activity in the human intestinal microflora by approximately 1.5- and 2.3-fold, respectively.	1,2-Dimethylhydrazine	0-3	glucuronidase beta	Homo sapiens	46-64
11604476-0	2001	1,2-Dimethylhydrazine-induced colon carcinoma and lymphoma in msh2(-/-) mice.	1,2-Dimethylhydrazine	0-21	mutS homolog 2	Mus musculus	62-66
11698353-0	2001	Predominant mutation of codon 41 of the beta-catenin proto-oncogene in rat colon tumors induced by 1,2-dimethylhydrazine using a complete carcinogenic protocol.	1,2-Dimethylhydrazine	99-120	catenin beta 1	Rattus norvegicus	40-52
11698353-4	2001	Unlike previous studies, that have used relatively short-term (2-5 weeks) treatment with one of the alkylating agents 1,2,-dimethylhydrazine (DMH) or azoxymethane, we have investigated the mutational spectrum of the beta-catenin gene in a panel of rat colon tumors induced by long-term (20 weeks) DMH-treatment.	1,2-Dimethylhydrazine	118-140	catenin beta 1	Rattus norvegicus	216-228
11840214-9	2001	In contrast to the widely distributed GLP-1 receptor mRNA, GLP-2 receptor mRNA is exclusively expressed in the compact part of the DMH (DMHc).	1,2-Dimethylhydrazine	131-134	glucagon-like peptide 2 receptor	Rattus norvegicus	59-73
11604476-9	2001	RESULTS: Homozygous inactivation of the msh2 gene statistically significantly accelerated (P&lt;.0001) death due to the development of DMH-induced colorectal tumors and lymphomas.	1,2-Dimethylhydrazine	135-138	mutS homolog 2	Mus musculus	40-44
11604476-11	2001	DMH induced apoptosis in small intestinal and colonic epithelial crypts that was dependent on active msh2.	1,2-Dimethylhydrazine	0-3	mutS homolog 2	Mus musculus	101-105