PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 16277605-1 2006 Previous studies have shown that brief application of group I metabotropic glutamate receptor (mGluR) agonist (S)-3, 5-dihydroxyphenylglycine (DHPG) to hippocampal slices can induce a chemical form of long-term depression (DHPG-LTD) in the hippocampal CA1 region; however, the expression mechanisms of this LTD remain unclear. dhpg 143-147 carbonic anhydrase 1 Homo sapiens 252-255 16495443-1 2006 Long-term depression (LTD) is an activity-dependent decrease in synaptic efficacy that can be induced in hippocampal area CA1 by pharmacological application of the selective group I metabotropic glutamate receptor (mGluR) agonist 3,5-diyhroxyphenylglycine (DHPG). dhpg 257-261 carbonic anhydrase 1 Homo sapiens 122-125 16495443-2 2006 Recent work has demonstrated that DHPG-induced LTD recruits at least two signal transduction pathways known to couple to translation, the mitogen-activated protein kinase kinase (MEK)-extracellular signal-regulated kinase (ERK) signaling pathway and the phosphoinositide 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) signaling pathway. dhpg 34-38 mitogen-activated protein kinase kinase 7 Homo sapiens 138-177 16495443-2 2006 Recent work has demonstrated that DHPG-induced LTD recruits at least two signal transduction pathways known to couple to translation, the mitogen-activated protein kinase kinase (MEK)-extracellular signal-regulated kinase (ERK) signaling pathway and the phosphoinositide 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) signaling pathway. dhpg 34-38 mitogen-activated protein kinase kinase 7 Homo sapiens 179-182 16495443-2 2006 Recent work has demonstrated that DHPG-induced LTD recruits at least two signal transduction pathways known to couple to translation, the mitogen-activated protein kinase kinase (MEK)-extracellular signal-regulated kinase (ERK) signaling pathway and the phosphoinositide 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) signaling pathway. dhpg 34-38 mitogen-activated protein kinase 1 Homo sapiens 223-226 16495443-2 2006 Recent work has demonstrated that DHPG-induced LTD recruits at least two signal transduction pathways known to couple to translation, the mitogen-activated protein kinase kinase (MEK)-extracellular signal-regulated kinase (ERK) signaling pathway and the phosphoinositide 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) signaling pathway. dhpg 34-38 mechanistic target of rapamycin kinase Homo sapiens 322-326 16495443-5 2006 We found that both the MEK-ERK and PI3K-mTOR signaling pathways are critical for the DHPG-induced regulation of these translation factors. dhpg 85-89 mitogen-activated protein kinase kinase 7 Homo sapiens 23-26 16495443-5 2006 We found that both the MEK-ERK and PI3K-mTOR signaling pathways are critical for the DHPG-induced regulation of these translation factors. dhpg 85-89 mitogen-activated protein kinase 1 Homo sapiens 27-30 16495443-5 2006 We found that both the MEK-ERK and PI3K-mTOR signaling pathways are critical for the DHPG-induced regulation of these translation factors. dhpg 85-89 mechanistic target of rapamycin kinase Homo sapiens 40-44 16495443-7 2006 Our results provide direct evidence that cap-dependent translation is engaged during mGluR-LTD and demonstrate that the MEK-ERK and PI3K-mTOR signaling pathways converge to regulate eIF4E activity after induction of DHPG-LTD. dhpg 216-220 mitogen-activated protein kinase kinase 7 Homo sapiens 120-123 16495443-7 2006 Our results provide direct evidence that cap-dependent translation is engaged during mGluR-LTD and demonstrate that the MEK-ERK and PI3K-mTOR signaling pathways converge to regulate eIF4E activity after induction of DHPG-LTD. dhpg 216-220 mitogen-activated protein kinase 1 Homo sapiens 124-127 16495443-7 2006 Our results provide direct evidence that cap-dependent translation is engaged during mGluR-LTD and demonstrate that the MEK-ERK and PI3K-mTOR signaling pathways converge to regulate eIF4E activity after induction of DHPG-LTD. dhpg 216-220 mechanistic target of rapamycin kinase Homo sapiens 137-141 16495443-7 2006 Our results provide direct evidence that cap-dependent translation is engaged during mGluR-LTD and demonstrate that the MEK-ERK and PI3K-mTOR signaling pathways converge to regulate eIF4E activity after induction of DHPG-LTD. dhpg 216-220 eukaryotic translation initiation factor 4E Homo sapiens 182-187 15936117-6 2005 Activation of type I metabotropic glutamate receptors (mGluRs) with DHPG (3,5-dihyidroxy-phenylglycine) activates PKC gamma but not PKC alpha or beta. dhpg 68-72 protein kinase C gamma Homo sapiens 114-123 9822771-6 1998 Furthermore, multireceptive dorsal horn neurons in mGluR1 antisense-treated rats were strongly excited by innocuous stimuli to their peripheral receptive fields, but showed severe reductions in their sustained excitatory responses to the selective C-fiber activator mustard oil and in responses to DHPG. dhpg 298-302 glutamate metabotropic receptor 1 Rattus norvegicus 51-57 12223474-1 2002 Previously, we reported that (S)-3,5-dihydroxypenylglycine (DHPG), an agonist for group I metabotropic glutamate receptors (mGluRs), stimulates CK1 and Cdk5 kinase activities in neostriatal neurons, leading to enhanced phosphorylation, respectively, of Ser-137 and Thr-75 of DARPP-32 (dopamine and cAMP-regulated phosphoprotein, 32 kDa). dhpg 60-64 protein phosphatase 1, regulatory inhibitor subunit 1B Mus musculus 275-283 11786145-5 2002 The neuromodulatory action of leptin (0.2 and 3 nM) on the overflow of noradrenaline and DHPG from the medulla and hypothalamus was examined. dhpg 89-93 leptin Rattus norvegicus 30-36 12717030-6 2003 The structure, chemical shifts, and spin-spin coupling constants all indicate that, of the four lysines in the N-terminal domain of IIA(Glc), only Lys 5 and Lys 7 in the amphipathic helical region interact with DHPG. dhpg 211-215 colicin Ia immunity protein Escherichia coli 132-135 10530819-0 1999 DHPG-induced LTD in area CA1 of juvenile rat hippocampus; characterisation and sensitivity to novel mGlu receptor antagonists. dhpg 0-4 carbonic anhydrase 1 Rattus norvegicus 25-28 10530819-8 1999 In conclusion, DHPG, probably via activation of mGlu5 receptors, is able to induce a robust form of LTD in the CA1 region of the young rat hippocampus that is mechanistically distinct from NMDA receptor-dependent homosynaptic LTD. dhpg 15-19 carbonic anhydrase 1 Rattus norvegicus 111-114 22188633-5 2012 Activation of mGluR5 with (RS)-3, 5-dihydroxy phenylglycine (DHPG) promoted cardiomyocyte differentiation in a dose-dependent manner. dhpg 61-65 glutamate receptor, ionotropic, kainate 1 Mus musculus 14-20 9728902-8 1998 MAO-A inhibition was estimated by multiple titrations of 3,4-dihydrophenylglycol (DHPG) in plasma. dhpg 82-86 monoamine oxidase A Homo sapiens 0-5 34390832-6 2021 Furthermore, cytohesin-2 conditional knockout mice exhibited reduced mechanical allodynia and ERK1/2 activation following the pharmacological activation of spinal mGluR1/5 with 3,5-dihydroxylphenylglycine (DHPG). dhpg 206-210 cytohesin 2 Mus musculus 13-24 34390832-6 2021 Furthermore, cytohesin-2 conditional knockout mice exhibited reduced mechanical allodynia and ERK1/2 activation following the pharmacological activation of spinal mGluR1/5 with 3,5-dihydroxylphenylglycine (DHPG). dhpg 206-210 mitogen-activated protein kinase 3 Mus musculus 94-100 34390832-6 2021 Furthermore, cytohesin-2 conditional knockout mice exhibited reduced mechanical allodynia and ERK1/2 activation following the pharmacological activation of spinal mGluR1/5 with 3,5-dihydroxylphenylglycine (DHPG). dhpg 206-210 glutamate receptor, metabotropic 1 Mus musculus 163-169 32545708-13 2020 In healthy subjects and in rheumatoid arthritis patients, the urinary excretion rate of DMA correlates positively with the excretion rate of dihydroxyphenylglycol (DHPG), the major urinary catecholamines metabolite, suggesting a potential interplay in the PRMT/DDAH/NO pathway. dhpg 164-168 dimethylarginine dimethylaminohydrolase 1 Homo sapiens 261-265 9729618-22 1998 L-type Ca2+ channels were modulated by an agonist for mGluR1/5 receptors, (S)-3, 5-dihydrophenylglycine (DHPG, 5 microM). dhpg 105-109 glutamate receptor, metabotropic 1 Mus musculus 54-60 9828911-14 1998 Urinary DHPG was lower (P < 0.01) in PCO patients (0.50 +/- 0.02 mumol/d) than in controls (0.73 +/- 0.09 mumol/d). dhpg 8-12 PCOS1 Homo sapiens 40-43 31073978-4 2019 In astroglial C6 cells, CAL deficiency blocked (S)-3, 5-dihydroxyphenylglycine (DHPG)-elicited p-AKT and p-ERK1/2, subsequently prevented group I mGluRs-mediated anti-apoptotic protection, which was blocked by receptor antagonist 1-aminoindan-1, 5-dicarboxylic acid (AIDA), and PI3K or MEK inhibitor LY294002 or U0126. dhpg 80-84 AKT serine/threonine kinase 1 Homo sapiens 97-100 31073978-4 2019 In astroglial C6 cells, CAL deficiency blocked (S)-3, 5-dihydroxyphenylglycine (DHPG)-elicited p-AKT and p-ERK1/2, subsequently prevented group I mGluRs-mediated anti-apoptotic protection, which was blocked by receptor antagonist 1-aminoindan-1, 5-dicarboxylic acid (AIDA), and PI3K or MEK inhibitor LY294002 or U0126. dhpg 80-84 mitogen-activated protein kinase 3 Homo sapiens 107-113 31073978-4 2019 In astroglial C6 cells, CAL deficiency blocked (S)-3, 5-dihydroxyphenylglycine (DHPG)-elicited p-AKT and p-ERK1/2, subsequently prevented group I mGluRs-mediated anti-apoptotic protection, which was blocked by receptor antagonist 1-aminoindan-1, 5-dicarboxylic acid (AIDA), and PI3K or MEK inhibitor LY294002 or U0126. dhpg 80-84 mitogen-activated protein kinase kinase 7 Homo sapiens 286-289 26902516-4 2016 Treatment with DHPG (100 muM) also promoted the proliferation of RPCs, as indicated by 5-Bromo-2-deoxyUridine (BrdU) staining and flow cytometry, and likewise, MTEP (100 muM) and mGluR5 knockdown abolished the action of mGluR5 activity. dhpg 15-19 glutamate receptor, ionotropic, kainate 1 Mus musculus 179-185 26902516-4 2016 Treatment with DHPG (100 muM) also promoted the proliferation of RPCs, as indicated by 5-Bromo-2-deoxyUridine (BrdU) staining and flow cytometry, and likewise, MTEP (100 muM) and mGluR5 knockdown abolished the action of mGluR5 activity. dhpg 15-19 glutamate receptor, ionotropic, kainate 1 Mus musculus 220-226 26902516-5 2016 Western blot demonstrated that the activation of mGluR5 enhanced the expression of Cyclin D1 and the phosphorylation level of PKC however, MTEP or mGluR5 knockdown also abrogated the effect of DHPG on RPCs. dhpg 193-197 glutamate receptor, ionotropic, kainate 1 Mus musculus 49-55 26902516-5 2016 Western blot demonstrated that the activation of mGluR5 enhanced the expression of Cyclin D1 and the phosphorylation level of PKC however, MTEP or mGluR5 knockdown also abrogated the effect of DHPG on RPCs. dhpg 193-197 cyclin D1 Rattus norvegicus 83-92 26902516-5 2016 Western blot demonstrated that the activation of mGluR5 enhanced the expression of Cyclin D1 and the phosphorylation level of PKC however, MTEP or mGluR5 knockdown also abrogated the effect of DHPG on RPCs. dhpg 193-197 glutamate receptor, ionotropic, kainate 1 Mus musculus 147-153 26902516-7 2016 After DHPG treatment, the levels of both p-ERK1/2 and p-AKT increased in a time-dependent manner. dhpg 6-10 mitogen activated protein kinase 3 Rattus norvegicus 43-49 26902516-7 2016 After DHPG treatment, the levels of both p-ERK1/2 and p-AKT increased in a time-dependent manner. dhpg 6-10 AKT serine/threonine kinase 1 Rattus norvegicus 56-59 26902516-8 2016 Then we used MTEP, mGluR5 knockdown, the ERK1/2 inhibitor U0126 and the AKT inhibitor LY294002 to pretreat the cells, and all of them clearly eliminated the influence of DHPG. dhpg 170-174 AKT serine/threonine kinase 1 Rattus norvegicus 72-75 25421413-7 2015 The effects of DHPG were abolished by the mGluR1 antagonist LY367385 and the specific inhibitor of MEK1, PD98059 which also reduced phosphorylation of extracellular-signal-regulated protein kinase 1/2 (ERK1/2); but not by the mGluR5 antagonist 6-methyl-2-(phenylethynyl) pyridine hydrochloride or the selective inhibitor of protein kinase C (PKC). dhpg 15-19 glutamate metabotropic receptor 1 Rattus norvegicus 42-48 25421413-7 2015 The effects of DHPG were abolished by the mGluR1 antagonist LY367385 and the specific inhibitor of MEK1, PD98059 which also reduced phosphorylation of extracellular-signal-regulated protein kinase 1/2 (ERK1/2); but not by the mGluR5 antagonist 6-methyl-2-(phenylethynyl) pyridine hydrochloride or the selective inhibitor of protein kinase C (PKC). dhpg 15-19 mitogen activated protein kinase kinase 1 Rattus norvegicus 99-103 25421413-7 2015 The effects of DHPG were abolished by the mGluR1 antagonist LY367385 and the specific inhibitor of MEK1, PD98059 which also reduced phosphorylation of extracellular-signal-regulated protein kinase 1/2 (ERK1/2); but not by the mGluR5 antagonist 6-methyl-2-(phenylethynyl) pyridine hydrochloride or the selective inhibitor of protein kinase C (PKC). dhpg 15-19 mitogen activated protein kinase 3 Rattus norvegicus 202-208 25421413-7 2015 The effects of DHPG were abolished by the mGluR1 antagonist LY367385 and the specific inhibitor of MEK1, PD98059 which also reduced phosphorylation of extracellular-signal-regulated protein kinase 1/2 (ERK1/2); but not by the mGluR5 antagonist 6-methyl-2-(phenylethynyl) pyridine hydrochloride or the selective inhibitor of protein kinase C (PKC). dhpg 15-19 glutamate receptor, ionotropic, kainate 1 Mus musculus 226-232 22188633-6 2012 DHPG significantly enhanced PI 3-kinase enhancer (PIKE) and PI3K p110alpha expression, but had no significant effect on Homer1b/c. dhpg 0-4 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 Mus musculus 28-48 22188633-6 2012 DHPG significantly enhanced PI 3-kinase enhancer (PIKE) and PI3K p110alpha expression, but had no significant effect on Homer1b/c. dhpg 0-4 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 Mus musculus 50-54 22188633-6 2012 DHPG significantly enhanced PI 3-kinase enhancer (PIKE) and PI3K p110alpha expression, but had no significant effect on Homer1b/c. dhpg 0-4 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Mus musculus 65-74 22188633-7 2012 The coexpression of PIKE or PI3K p110alpha together with Troponin T in embryoid bodies (EBs) treated with DHPG was elevated to 9.51% and 12.05%, respectively. dhpg 106-110 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 Mus musculus 20-24 22188633-7 2012 The coexpression of PIKE or PI3K p110alpha together with Troponin T in embryoid bodies (EBs) treated with DHPG was elevated to 9.51% and 12.05%, respectively. dhpg 106-110 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Mus musculus 33-42 22188633-11 2012 mGluR5 siRNA also decreased the DHPG-induced Ca2+ transient peak amplitude in the isolated ESC-derived cardiomyocytes. dhpg 32-36 glutamate receptor, ionotropic, kainate 1 Mus musculus 0-6 17306466-5 2007 Moreover, the DHPG-induced mechanical hypersensitivity was significantly blocked by inhibiting either the alpha or epsilon isoform of protein kinase C (PKC). dhpg 14-18 protein kinase C, alpha Rattus norvegicus 152-155 21593322-4 2011 DHPG induced a transient increase in the level of phospho-CaMKII (phospho-CaMKII(T286)) in synaptoneurosomes prepared from whole hippocampus and in CA1 minislices. dhpg 0-4 carbonic anhydrase 1 Rattus norvegicus 148-151 21593322-6 2011 In field recordings from CA1, both the translation inhibitor cycloheximide and KN62 significantly reduced DHPG-induced LTD. dhpg 106-110 carbonic anhydrase 1 Rattus norvegicus 25-28 20053912-6 2010 Despite of decreased InsP formation, (S)-3,5-dihydroxylphenylglycine (DHPG)-mediated Ca(2+) release is higher in Hdh(Q111/Q111) than in Hdh(Q20/Q20) neurons. dhpg 70-74 huntingtin Mus musculus 113-116 20053912-6 2010 Despite of decreased InsP formation, (S)-3,5-dihydroxylphenylglycine (DHPG)-mediated Ca(2+) release is higher in Hdh(Q111/Q111) than in Hdh(Q20/Q20) neurons. dhpg 70-74 huntingtin Mus musculus 136-139 20053912-10 2010 PKC inhibition not only brings Hdh(Q111/Q111) DHPG-stimulated InsP formation to Hdh(Q20/Q20) levels, but also causes an increase in neuronal cell death in Hdh(Q111/Q111) neurons. dhpg 46-50 huntingtin Mus musculus 31-34 20053912-10 2010 PKC inhibition not only brings Hdh(Q111/Q111) DHPG-stimulated InsP formation to Hdh(Q20/Q20) levels, but also causes an increase in neuronal cell death in Hdh(Q111/Q111) neurons. dhpg 46-50 huntingtin Mus musculus 80-83 20053912-10 2010 PKC inhibition not only brings Hdh(Q111/Q111) DHPG-stimulated InsP formation to Hdh(Q20/Q20) levels, but also causes an increase in neuronal cell death in Hdh(Q111/Q111) neurons. dhpg 46-50 huntingtin Mus musculus 80-83 18279362-9 2008 By contrast, activation of mGluR1 by the agonist (R,S)3,5-dihydroxyphenylglycine (DHPG) rescued RP induction from its suppression by GABA(B)R activation. dhpg 82-86 glutamate metabotropic receptor 1 Rattus norvegicus 27-33 21723923-3 2011 Results showed that mGluR5 agonist (S)-3,5-dihydroxyphenylglycine hydrate (DHPG) increased the proliferation of NPCs by increasing cell activity, diameter of neurospheres and cell division, while mGluR5 siRNA and antagonist 6-methyl-2-(phenylethynyl) pyridine hydrochloride (MPEP) decreased the NPC proliferation. dhpg 75-79 glutamate receptor, ionotropic, kainate 1 Mus musculus 20-26 21723923-3 2011 Results showed that mGluR5 agonist (S)-3,5-dihydroxyphenylglycine hydrate (DHPG) increased the proliferation of NPCs by increasing cell activity, diameter of neurospheres and cell division, while mGluR5 siRNA and antagonist 6-methyl-2-(phenylethynyl) pyridine hydrochloride (MPEP) decreased the NPC proliferation. dhpg 75-79 glutamate receptor, ionotropic, kainate 1 Mus musculus 196-202 21723923-6 2011 After DHPG treatment, p-ERK1/2 and p-JNK2 levels increased, and meanwhile p-p38 level decreased; but p-ERK1/2 and p-JNK2 levels decreased after siRNA or MPEP treatment, and p-p38 level increased. dhpg 6-10 mitogen-activated protein kinase 3 Homo sapiens 24-30 21723923-6 2011 After DHPG treatment, p-ERK1/2 and p-JNK2 levels increased, and meanwhile p-p38 level decreased; but p-ERK1/2 and p-JNK2 levels decreased after siRNA or MPEP treatment, and p-p38 level increased. dhpg 6-10 mitogen-activated protein kinase 9 Homo sapiens 37-41