PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
16277605-1	2006	Previous studies have shown that brief application of group I metabotropic glutamate receptor (mGluR) agonist (S)-3, 5-dihydroxyphenylglycine (DHPG) to hippocampal slices can induce a chemical form of long-term depression (DHPG-LTD) in the hippocampal CA1 region; however, the expression mechanisms of this LTD remain unclear.	dhpg	143-147	carbonic anhydrase 1	Homo sapiens	252-255
16495443-1	2006	Long-term depression (LTD) is an activity-dependent decrease in synaptic efficacy that can be induced in hippocampal area CA1 by pharmacological application of the selective group I metabotropic glutamate receptor (mGluR) agonist 3,5-diyhroxyphenylglycine (DHPG).	dhpg	257-261	carbonic anhydrase 1	Homo sapiens	122-125
16495443-2	2006	Recent work has demonstrated that DHPG-induced LTD recruits at least two signal transduction pathways known to couple to translation, the mitogen-activated protein kinase kinase (MEK)-extracellular signal-regulated kinase (ERK) signaling pathway and the phosphoinositide 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) signaling pathway.	dhpg	34-38	mitogen-activated protein kinase kinase 7	Homo sapiens	138-177
16495443-2	2006	Recent work has demonstrated that DHPG-induced LTD recruits at least two signal transduction pathways known to couple to translation, the mitogen-activated protein kinase kinase (MEK)-extracellular signal-regulated kinase (ERK) signaling pathway and the phosphoinositide 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) signaling pathway.	dhpg	34-38	mitogen-activated protein kinase kinase 7	Homo sapiens	179-182
16495443-2	2006	Recent work has demonstrated that DHPG-induced LTD recruits at least two signal transduction pathways known to couple to translation, the mitogen-activated protein kinase kinase (MEK)-extracellular signal-regulated kinase (ERK) signaling pathway and the phosphoinositide 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) signaling pathway.	dhpg	34-38	mitogen-activated protein kinase 1	Homo sapiens	223-226
16495443-2	2006	Recent work has demonstrated that DHPG-induced LTD recruits at least two signal transduction pathways known to couple to translation, the mitogen-activated protein kinase kinase (MEK)-extracellular signal-regulated kinase (ERK) signaling pathway and the phosphoinositide 3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) signaling pathway.	dhpg	34-38	mechanistic target of rapamycin kinase	Homo sapiens	322-326
16495443-5	2006	We found that both the MEK-ERK and PI3K-mTOR signaling pathways are critical for the DHPG-induced regulation of these translation factors.	dhpg	85-89	mitogen-activated protein kinase kinase 7	Homo sapiens	23-26
16495443-5	2006	We found that both the MEK-ERK and PI3K-mTOR signaling pathways are critical for the DHPG-induced regulation of these translation factors.	dhpg	85-89	mitogen-activated protein kinase 1	Homo sapiens	27-30
16495443-5	2006	We found that both the MEK-ERK and PI3K-mTOR signaling pathways are critical for the DHPG-induced regulation of these translation factors.	dhpg	85-89	mechanistic target of rapamycin kinase	Homo sapiens	40-44
16495443-7	2006	Our results provide direct evidence that cap-dependent translation is engaged during mGluR-LTD and demonstrate that the MEK-ERK and PI3K-mTOR signaling pathways converge to regulate eIF4E activity after induction of DHPG-LTD.	dhpg	216-220	mitogen-activated protein kinase kinase 7	Homo sapiens	120-123
16495443-7	2006	Our results provide direct evidence that cap-dependent translation is engaged during mGluR-LTD and demonstrate that the MEK-ERK and PI3K-mTOR signaling pathways converge to regulate eIF4E activity after induction of DHPG-LTD.	dhpg	216-220	mitogen-activated protein kinase 1	Homo sapiens	124-127
16495443-7	2006	Our results provide direct evidence that cap-dependent translation is engaged during mGluR-LTD and demonstrate that the MEK-ERK and PI3K-mTOR signaling pathways converge to regulate eIF4E activity after induction of DHPG-LTD.	dhpg	216-220	mechanistic target of rapamycin kinase	Homo sapiens	137-141
16495443-7	2006	Our results provide direct evidence that cap-dependent translation is engaged during mGluR-LTD and demonstrate that the MEK-ERK and PI3K-mTOR signaling pathways converge to regulate eIF4E activity after induction of DHPG-LTD.	dhpg	216-220	eukaryotic translation initiation factor 4E	Homo sapiens	182-187
15936117-6	2005	Activation of type I metabotropic glutamate receptors (mGluRs) with DHPG (3,5-dihyidroxy-phenylglycine) activates PKC gamma but not PKC alpha or beta.	dhpg	68-72	protein kinase C gamma	Homo sapiens	114-123
9822771-6	1998	Furthermore, multireceptive dorsal horn neurons in mGluR1 antisense-treated rats were strongly excited by innocuous stimuli to their peripheral receptive fields, but showed severe reductions in their sustained excitatory responses to the selective C-fiber activator mustard oil and in responses to DHPG.	dhpg	298-302	glutamate metabotropic receptor 1	Rattus norvegicus	51-57
12223474-1	2002	Previously, we reported that (S)-3,5-dihydroxypenylglycine (DHPG), an agonist for group I metabotropic glutamate receptors (mGluRs), stimulates CK1 and Cdk5 kinase activities in neostriatal neurons, leading to enhanced phosphorylation, respectively, of Ser-137 and Thr-75 of DARPP-32 (dopamine and cAMP-regulated phosphoprotein, 32 kDa).	dhpg	60-64	protein phosphatase 1, regulatory inhibitor subunit 1B	Mus musculus	275-283
11786145-5	2002	The neuromodulatory action of leptin (0.2 and 3 nM) on the overflow of noradrenaline and DHPG from the medulla and hypothalamus was examined.	dhpg	89-93	leptin	Rattus norvegicus	30-36
12717030-6	2003	The structure, chemical shifts, and spin-spin coupling constants all indicate that, of the four lysines in the N-terminal domain of IIA(Glc), only Lys 5 and Lys 7 in the amphipathic helical region interact with DHPG.	dhpg	211-215	colicin Ia immunity protein	Escherichia coli	132-135
10530819-0	1999	DHPG-induced LTD in area CA1 of juvenile rat hippocampus; characterisation and sensitivity to novel mGlu receptor antagonists.	dhpg	0-4	carbonic anhydrase 1	Rattus norvegicus	25-28
10530819-8	1999	In conclusion, DHPG, probably via activation of mGlu5 receptors, is able to induce a robust form of LTD in the CA1 region of the young rat hippocampus that is mechanistically distinct from NMDA receptor-dependent homosynaptic LTD.	dhpg	15-19	carbonic anhydrase 1	Rattus norvegicus	111-114
22188633-5	2012	Activation of mGluR5 with (RS)-3, 5-dihydroxy phenylglycine (DHPG) promoted cardiomyocyte differentiation in a dose-dependent manner.	dhpg	61-65	glutamate receptor, ionotropic, kainate 1	Mus musculus	14-20
9728902-8	1998	MAO-A inhibition was estimated by multiple titrations of 3,4-dihydrophenylglycol (DHPG) in plasma.	dhpg	82-86	monoamine oxidase A	Homo sapiens	0-5
34390832-6	2021	Furthermore, cytohesin-2 conditional knockout mice exhibited reduced mechanical allodynia and ERK1/2 activation following the pharmacological activation of spinal mGluR1/5 with 3,5-dihydroxylphenylglycine (DHPG).	dhpg	206-210	cytohesin 2	Mus musculus	13-24
34390832-6	2021	Furthermore, cytohesin-2 conditional knockout mice exhibited reduced mechanical allodynia and ERK1/2 activation following the pharmacological activation of spinal mGluR1/5 with 3,5-dihydroxylphenylglycine (DHPG).	dhpg	206-210	mitogen-activated protein kinase 3	Mus musculus	94-100
34390832-6	2021	Furthermore, cytohesin-2 conditional knockout mice exhibited reduced mechanical allodynia and ERK1/2 activation following the pharmacological activation of spinal mGluR1/5 with 3,5-dihydroxylphenylglycine (DHPG).	dhpg	206-210	glutamate receptor, metabotropic 1	Mus musculus	163-169
32545708-13	2020	In healthy subjects and in rheumatoid arthritis patients, the urinary excretion rate of DMA correlates positively with the excretion rate of dihydroxyphenylglycol (DHPG), the major urinary catecholamines metabolite, suggesting a potential interplay in the PRMT/DDAH/NO pathway.	dhpg	164-168	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	261-265
9729618-22	1998	L-type Ca2+ channels were modulated by an agonist for mGluR1/5 receptors, (S)-3, 5-dihydrophenylglycine (DHPG, 5 microM).	dhpg	105-109	glutamate receptor, metabotropic 1	Mus musculus	54-60
9828911-14	1998	Urinary DHPG was lower (P < 0.01) in PCO patients (0.50 +/- 0.02 mumol/d) than in controls (0.73 +/- 0.09 mumol/d).	dhpg	8-12	PCOS1	Homo sapiens	40-43
31073978-4	2019	In astroglial C6 cells, CAL deficiency blocked (S)-3, 5-dihydroxyphenylglycine (DHPG)-elicited p-AKT and p-ERK1/2, subsequently prevented group I mGluRs-mediated anti-apoptotic protection, which was blocked by receptor antagonist 1-aminoindan-1, 5-dicarboxylic acid (AIDA), and PI3K or MEK inhibitor LY294002 or U0126.	dhpg	80-84	AKT serine/threonine kinase 1	Homo sapiens	97-100
31073978-4	2019	In astroglial C6 cells, CAL deficiency blocked (S)-3, 5-dihydroxyphenylglycine (DHPG)-elicited p-AKT and p-ERK1/2, subsequently prevented group I mGluRs-mediated anti-apoptotic protection, which was blocked by receptor antagonist 1-aminoindan-1, 5-dicarboxylic acid (AIDA), and PI3K or MEK inhibitor LY294002 or U0126.	dhpg	80-84	mitogen-activated protein kinase 3	Homo sapiens	107-113
31073978-4	2019	In astroglial C6 cells, CAL deficiency blocked (S)-3, 5-dihydroxyphenylglycine (DHPG)-elicited p-AKT and p-ERK1/2, subsequently prevented group I mGluRs-mediated anti-apoptotic protection, which was blocked by receptor antagonist 1-aminoindan-1, 5-dicarboxylic acid (AIDA), and PI3K or MEK inhibitor LY294002 or U0126.	dhpg	80-84	mitogen-activated protein kinase kinase 7	Homo sapiens	286-289
26902516-4	2016	Treatment with DHPG (100 muM) also promoted the proliferation of RPCs, as indicated by 5-Bromo-2-deoxyUridine (BrdU) staining and flow cytometry, and likewise, MTEP (100 muM) and mGluR5 knockdown abolished the action of mGluR5 activity.	dhpg	15-19	glutamate receptor, ionotropic, kainate 1	Mus musculus	179-185
26902516-4	2016	Treatment with DHPG (100 muM) also promoted the proliferation of RPCs, as indicated by 5-Bromo-2-deoxyUridine (BrdU) staining and flow cytometry, and likewise, MTEP (100 muM) and mGluR5 knockdown abolished the action of mGluR5 activity.	dhpg	15-19	glutamate receptor, ionotropic, kainate 1	Mus musculus	220-226
26902516-5	2016	Western blot demonstrated that the activation of mGluR5 enhanced the expression of Cyclin D1 and the phosphorylation level of PKC however, MTEP or mGluR5 knockdown also abrogated the effect of DHPG on RPCs.	dhpg	193-197	glutamate receptor, ionotropic, kainate 1	Mus musculus	49-55
26902516-5	2016	Western blot demonstrated that the activation of mGluR5 enhanced the expression of Cyclin D1 and the phosphorylation level of PKC however, MTEP or mGluR5 knockdown also abrogated the effect of DHPG on RPCs.	dhpg	193-197	cyclin D1	Rattus norvegicus	83-92
26902516-5	2016	Western blot demonstrated that the activation of mGluR5 enhanced the expression of Cyclin D1 and the phosphorylation level of PKC however, MTEP or mGluR5 knockdown also abrogated the effect of DHPG on RPCs.	dhpg	193-197	glutamate receptor, ionotropic, kainate 1	Mus musculus	147-153
26902516-7	2016	After DHPG treatment, the levels of both p-ERK1/2 and p-AKT increased in a time-dependent manner.	dhpg	6-10	mitogen activated protein kinase 3	Rattus norvegicus	43-49
26902516-7	2016	After DHPG treatment, the levels of both p-ERK1/2 and p-AKT increased in a time-dependent manner.	dhpg	6-10	AKT serine/threonine kinase 1	Rattus norvegicus	56-59
26902516-8	2016	Then we used MTEP, mGluR5 knockdown, the ERK1/2 inhibitor U0126 and the AKT inhibitor LY294002 to pretreat the cells, and all of them clearly eliminated the influence of DHPG.	dhpg	170-174	AKT serine/threonine kinase 1	Rattus norvegicus	72-75
25421413-7	2015	The effects of DHPG were abolished by the mGluR1 antagonist LY367385 and the specific inhibitor of MEK1, PD98059 which also reduced phosphorylation of extracellular-signal-regulated protein kinase 1/2 (ERK1/2); but not by the mGluR5 antagonist 6-methyl-2-(phenylethynyl) pyridine hydrochloride or the selective inhibitor of protein kinase C (PKC).	dhpg	15-19	glutamate metabotropic receptor 1	Rattus norvegicus	42-48
25421413-7	2015	The effects of DHPG were abolished by the mGluR1 antagonist LY367385 and the specific inhibitor of MEK1, PD98059 which also reduced phosphorylation of extracellular-signal-regulated protein kinase 1/2 (ERK1/2); but not by the mGluR5 antagonist 6-methyl-2-(phenylethynyl) pyridine hydrochloride or the selective inhibitor of protein kinase C (PKC).	dhpg	15-19	mitogen activated protein kinase kinase 1	Rattus norvegicus	99-103
25421413-7	2015	The effects of DHPG were abolished by the mGluR1 antagonist LY367385 and the specific inhibitor of MEK1, PD98059 which also reduced phosphorylation of extracellular-signal-regulated protein kinase 1/2 (ERK1/2); but not by the mGluR5 antagonist 6-methyl-2-(phenylethynyl) pyridine hydrochloride or the selective inhibitor of protein kinase C (PKC).	dhpg	15-19	mitogen activated protein kinase 3	Rattus norvegicus	202-208
25421413-7	2015	The effects of DHPG were abolished by the mGluR1 antagonist LY367385 and the specific inhibitor of MEK1, PD98059 which also reduced phosphorylation of extracellular-signal-regulated protein kinase 1/2 (ERK1/2); but not by the mGluR5 antagonist 6-methyl-2-(phenylethynyl) pyridine hydrochloride or the selective inhibitor of protein kinase C (PKC).	dhpg	15-19	glutamate receptor, ionotropic, kainate 1	Mus musculus	226-232
22188633-6	2012	DHPG significantly enhanced PI 3-kinase enhancer (PIKE) and PI3K p110alpha expression, but had no significant effect on Homer1b/c.	dhpg	0-4	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	Mus musculus	28-48
22188633-6	2012	DHPG significantly enhanced PI 3-kinase enhancer (PIKE) and PI3K p110alpha expression, but had no significant effect on Homer1b/c.	dhpg	0-4	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	Mus musculus	50-54
22188633-6	2012	DHPG significantly enhanced PI 3-kinase enhancer (PIKE) and PI3K p110alpha expression, but had no significant effect on Homer1b/c.	dhpg	0-4	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Mus musculus	65-74
22188633-7	2012	The coexpression of PIKE or PI3K p110alpha together with Troponin T in embryoid bodies (EBs) treated with DHPG was elevated to 9.51% and 12.05%, respectively.	dhpg	106-110	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	Mus musculus	20-24
22188633-7	2012	The coexpression of PIKE or PI3K p110alpha together with Troponin T in embryoid bodies (EBs) treated with DHPG was elevated to 9.51% and 12.05%, respectively.	dhpg	106-110	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Mus musculus	33-42
22188633-11	2012	mGluR5 siRNA also decreased the DHPG-induced Ca2+ transient peak amplitude in the isolated ESC-derived cardiomyocytes.	dhpg	32-36	glutamate receptor, ionotropic, kainate 1	Mus musculus	0-6
17306466-5	2007	Moreover, the DHPG-induced mechanical hypersensitivity was significantly blocked by inhibiting either the alpha or epsilon isoform of protein kinase C (PKC).	dhpg	14-18	protein kinase C, alpha	Rattus norvegicus	152-155
21593322-4	2011	DHPG induced a transient increase in the level of phospho-CaMKII (phospho-CaMKII(T286)) in synaptoneurosomes prepared from whole hippocampus and in CA1 minislices.	dhpg	0-4	carbonic anhydrase 1	Rattus norvegicus	148-151
21593322-6	2011	In field recordings from CA1, both the translation inhibitor cycloheximide and KN62 significantly reduced DHPG-induced LTD.	dhpg	106-110	carbonic anhydrase 1	Rattus norvegicus	25-28
20053912-6	2010	Despite of decreased InsP formation, (S)-3,5-dihydroxylphenylglycine (DHPG)-mediated Ca(2+) release is higher in Hdh(Q111/Q111) than in Hdh(Q20/Q20) neurons.	dhpg	70-74	huntingtin	Mus musculus	113-116
20053912-6	2010	Despite of decreased InsP formation, (S)-3,5-dihydroxylphenylglycine (DHPG)-mediated Ca(2+) release is higher in Hdh(Q111/Q111) than in Hdh(Q20/Q20) neurons.	dhpg	70-74	huntingtin	Mus musculus	136-139
20053912-10	2010	PKC inhibition not only brings Hdh(Q111/Q111) DHPG-stimulated InsP formation to Hdh(Q20/Q20) levels, but also causes an increase in neuronal cell death in Hdh(Q111/Q111) neurons.	dhpg	46-50	huntingtin	Mus musculus	31-34
20053912-10	2010	PKC inhibition not only brings Hdh(Q111/Q111) DHPG-stimulated InsP formation to Hdh(Q20/Q20) levels, but also causes an increase in neuronal cell death in Hdh(Q111/Q111) neurons.	dhpg	46-50	huntingtin	Mus musculus	80-83
20053912-10	2010	PKC inhibition not only brings Hdh(Q111/Q111) DHPG-stimulated InsP formation to Hdh(Q20/Q20) levels, but also causes an increase in neuronal cell death in Hdh(Q111/Q111) neurons.	dhpg	46-50	huntingtin	Mus musculus	80-83
18279362-9	2008	By contrast, activation of mGluR1 by the agonist (R,S)3,5-dihydroxyphenylglycine (DHPG) rescued RP induction from its suppression by GABA(B)R activation.	dhpg	82-86	glutamate metabotropic receptor 1	Rattus norvegicus	27-33
21723923-3	2011	Results showed that mGluR5 agonist (S)-3,5-dihydroxyphenylglycine hydrate (DHPG) increased the proliferation of NPCs by increasing cell activity, diameter of neurospheres and cell division, while mGluR5 siRNA and antagonist 6-methyl-2-(phenylethynyl) pyridine hydrochloride (MPEP) decreased the NPC proliferation.	dhpg	75-79	glutamate receptor, ionotropic, kainate 1	Mus musculus	20-26
21723923-3	2011	Results showed that mGluR5 agonist (S)-3,5-dihydroxyphenylglycine hydrate (DHPG) increased the proliferation of NPCs by increasing cell activity, diameter of neurospheres and cell division, while mGluR5 siRNA and antagonist 6-methyl-2-(phenylethynyl) pyridine hydrochloride (MPEP) decreased the NPC proliferation.	dhpg	75-79	glutamate receptor, ionotropic, kainate 1	Mus musculus	196-202
21723923-6	2011	After DHPG treatment, p-ERK1/2 and p-JNK2 levels increased, and meanwhile p-p38 level decreased; but p-ERK1/2 and p-JNK2 levels decreased after siRNA or MPEP treatment, and p-p38 level increased.	dhpg	6-10	mitogen-activated protein kinase 3	Homo sapiens	24-30
21723923-6	2011	After DHPG treatment, p-ERK1/2 and p-JNK2 levels increased, and meanwhile p-p38 level decreased; but p-ERK1/2 and p-JNK2 levels decreased after siRNA or MPEP treatment, and p-p38 level increased.	dhpg	6-10	mitogen-activated protein kinase 9	Homo sapiens	37-41