PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
17760865-3	2007	This TRH-induced suppression of food intake was attenuated partially in histamine-depleted rats pre-treated with alpha-fluoromethylhistidine (a specific suicide inhibitor of histidine decarboxylase) and in mice with targeted disruption of histamine H1 receptors.	alpha-fluoromethylhistidine	113-140	thyrotropin releasing hormone	Rattus norvegicus	5-8
19818811-0	2010	Alpha-fluoromethylhistidine, a histamine synthesis inhibitor, inhibits orexin-induced wakefulness in rats.	alpha-fluoromethylhistidine	0-27	hypocretin neuropeptide precursor	Rattus norvegicus	71-77
19818811-4	2010	injection of alpha-fluoromethylhistidine (alpha-FMH), a histamine synthesis inhibitor, on orexin-induced wakefulness in freely behaving rats.	alpha-fluoromethylhistidine	13-40	hypocretin neuropeptide precursor	Rattus norvegicus	90-96
19818811-4	2010	injection of alpha-fluoromethylhistidine (alpha-FMH), a histamine synthesis inhibitor, on orexin-induced wakefulness in freely behaving rats.	alpha-fluoromethylhistidine	42-51	hypocretin neuropeptide precursor	Rattus norvegicus	90-96
19818811-10	2010	Orexin-B at a dose of 10 nmol/h markedly increased the amount of wakefulness by 99.4% (p<0.05) over the baseline value, whereas alpha-FMH decreased orexin-B-induced wakefulness by 48.8%.	alpha-fluoromethylhistidine	131-140	hypocretin neuropeptide precursor	Rattus norvegicus	151-157
19818811-11	2010	Orexin-B-induced suppression of non-REM sleep was reversed by alpha-FMH treatment.	alpha-fluoromethylhistidine	62-71	hypocretin neuropeptide precursor	Rattus norvegicus	0-6
19818811-12	2010	Pretreatment with alpha-FMH, significantly inhibited orexin-B-induced wakefulness in rats.	alpha-fluoromethylhistidine	18-27	hypocretin neuropeptide precursor	Rattus norvegicus	53-59
18565206-6	2008	HA release and HA-mediated contractile responses upon sympathetic nerve stimulation were significantly inhibited by pre-treatment of histidine decarboxylase inhibitor alpha-fluoromethylhistidine.	alpha-fluoromethylhistidine	167-194	histidine decarboxylase	Cavia porcellus	133-156
18474684-13	2008	In agreement, both imidazole H3R antagonists, a nonimidazole H3R antagonist, and the HDC inhibitor alpha-monofluoromethyl histidine increased cell proliferation (up to approximately 60%), revealing a H3R-mediated inhibition by endogenous HA.	alpha-fluoromethylhistidine	99-131	histidine decarboxylase	Rattus norvegicus	85-88
17760865-3	2007	This TRH-induced suppression of food intake was attenuated partially in histamine-depleted rats pre-treated with alpha-fluoromethylhistidine (a specific suicide inhibitor of histidine decarboxylase) and in mice with targeted disruption of histamine H1 receptors.	alpha-fluoromethylhistidine	113-140	histidine decarboxylase	Rattus norvegicus	174-197
17169331-4	2007	The protection by carnosine was reversed by alpha- fluoromethylhistidine, a selective and irreversible inhibitor of histidine decarboxylase (HDC).	alpha-fluoromethylhistidine	44-72	histidine decarboxylase	Rattus norvegicus	116-139
17531387-7	2007	In experiment 3, we intraperitoneally injected fluoromethylhistidine (FMH), an antagonistic inhibitor of HDC, in rats fed with a histidine-enriched diet.	alpha-fluoromethylhistidine	70-73	histidine decarboxylase	Rattus norvegicus	105-108
17169331-4	2007	The protection by carnosine was reversed by alpha- fluoromethylhistidine, a selective and irreversible inhibitor of histidine decarboxylase (HDC).	alpha-fluoromethylhistidine	44-72	histidine decarboxylase	Rattus norvegicus	141-144
17141473-5	2007	Furthermore, intracerebroventricular injection of alpha-fluoromethylhistidine (100 microg), a selective and irreversible histidine decarboxylase inhibitor, mimicked the attenuation of PSP induced by the lesion of TM E2-region.	alpha-fluoromethylhistidine	50-77	histidine decarboxylase	Rattus norvegicus	121-144
16061728-8	2005	Their production was enhanced when histamine synthesis was blocked by the specific HDC inhibitor alpha-fluoro-methyl histidine, and underscored the determinant role of histamine in the inhibitory effect.	alpha-fluoromethylhistidine	97-126	histidine decarboxylase	Mus musculus	83-86
15894564-4	2005	The GLP-1-induced suppression of feeding was partially attenuated by intraperitoneal pretreatment with alpha-fluoromethylhistidine (FMH), a specific suicide inhibitor of histidine decarboxylase, which depletes hypothalamic neuronal histamine.	alpha-fluoromethylhistidine	103-130	glucagon	Rattus norvegicus	4-9
15894564-4	2005	The GLP-1-induced suppression of feeding was partially attenuated by intraperitoneal pretreatment with alpha-fluoromethylhistidine (FMH), a specific suicide inhibitor of histidine decarboxylase, which depletes hypothalamic neuronal histamine.	alpha-fluoromethylhistidine	132-135	glucagon	Rattus norvegicus	4-9
15662050-9	2005	Pretreatment with the irreversible inhibitor of histidine decarboxylase, alpha-fluoromethylhistidine, which is known to eliminate histamine from ECL cells, prevented the rise in microdialysate histamine.	alpha-fluoromethylhistidine	73-100	histidine decarboxylase	Rattus norvegicus	48-71
15084444-5	2004	alpha-Fluoromethylhistidine (FMH, 25 microg per site), a selective histidine decarboxylase inhibitor prevented the ameliorating effect of clobenpropit on the working memory deficits induced by MK-801.	alpha-fluoromethylhistidine	0-27	histidine decarboxylase	Rattus norvegicus	67-90
15084444-5	2004	alpha-Fluoromethylhistidine (FMH, 25 microg per site), a selective histidine decarboxylase inhibitor prevented the ameliorating effect of clobenpropit on the working memory deficits induced by MK-801.	alpha-fluoromethylhistidine	29-32	histidine decarboxylase	Rattus norvegicus	67-90
12871584-4	2003	A single injection of the histidine decarboxylase (HDC) inhibitor, alpha-fluoromethylhistidine (alpha-FMH), gave rise to a rapid reduction in zebrafish brain HA.	alpha-fluoromethylhistidine	67-94	histidine decarboxylase	Danio rerio	26-49
15179677-5	2004	H(3)receptor agonist, immepip, and histidine decarboxylase, alpha-fluoromethylhistidine reversed the ameliorating effect of clobenpropit on seizure development in a dose-dependent manner.	alpha-fluoromethylhistidine	60-87	histidine decarboxylase	Rattus norvegicus	35-58
15021962-8	2004	Treatment of the cells with alpha-fluoromethyl-histidine, a specific inhibitor of HDC, or histaminase increased IFN-gamma from CD8+ cells, whereas it had no appreciable effect on IL-4 secretion from CD4+ cells.	alpha-fluoromethylhistidine	28-56	interferon gamma	Mus musculus	112-121
12972479-7	2003	The addition of alpha-fluoromethylhistidine, a specific inhibitor of histidine decarboxylase (the enzyme responsible for histamine production), reduced the rate of proliferation of HAC.	alpha-fluoromethylhistidine	16-43	histidine decarboxylase	Homo sapiens	69-92
12871584-4	2003	A single injection of the histidine decarboxylase (HDC) inhibitor, alpha-fluoromethylhistidine (alpha-FMH), gave rise to a rapid reduction in zebrafish brain HA.	alpha-fluoromethylhistidine	67-94	histidine decarboxylase	Danio rerio	51-54
12871584-4	2003	A single injection of the histidine decarboxylase (HDC) inhibitor, alpha-fluoromethylhistidine (alpha-FMH), gave rise to a rapid reduction in zebrafish brain HA.	alpha-fluoromethylhistidine	96-105	histidine decarboxylase	Danio rerio	26-49
12871584-4	2003	A single injection of the histidine decarboxylase (HDC) inhibitor, alpha-fluoromethylhistidine (alpha-FMH), gave rise to a rapid reduction in zebrafish brain HA.	alpha-fluoromethylhistidine	96-105	histidine decarboxylase	Danio rerio	51-54
12871584-5	2003	Low HDC activity in the brain after injections verified the effect of alpha-FMH.	alpha-fluoromethylhistidine	70-79	histidine decarboxylase	Danio rerio	4-7
12609753-8	2003	Prior administration of alpha-FMH prevented the leptin-induced decrease in food intake.	alpha-fluoromethylhistidine	24-33	leptin	Rattus norvegicus	48-54
11931695-5	2002	The inhibitory action of histidine was enhanced significantly by thioperamide (5 microg), however, was antagonized by both alpha fluoromethylhistidine (20 microg), a selective histidine decarboxylase inhibitor and H1 ant agonist pyrilamine (2, 5 mg/kg), dose-dependently and significantly.	alpha-fluoromethylhistidine	123-150	histidine decarboxylase	Rattus norvegicus	176-199
12818259-10	2003	CONCLUSIONS: Thrombin inhibition produced by sulodexide is due to the additive effect of its components, namely, HCII catalysis by DS and AT catalysis by FMH.	alpha-fluoromethylhistidine	154-157	coagulation factor II, thrombin	Homo sapiens	13-21
12818259-10	2003	CONCLUSIONS: Thrombin inhibition produced by sulodexide is due to the additive effect of its components, namely, HCII catalysis by DS and AT catalysis by FMH.	alpha-fluoromethylhistidine	154-157	serpin family D member 1	Homo sapiens	113-117
12196593-7	2002	In WT mice, indeed, intraperitoneal injection of alpha-fluoromethylhistidine (HDC-inhibitor) caused a decrease in W, whereas injection of ciproxifan (HA-H3 receptor antagonist) elicited W. Both injections had no effect in HDC-/-mice.	alpha-fluoromethylhistidine	49-76	histidine decarboxylase	Mus musculus	78-81
12371609-4	2002	The significance of in situ generated histamine was shown on colony formation by inhibitory action of alphaFMH (blocking HDC activity, i.e. de novo histamine formation) and by N,N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine-HCl (DPPE) disturbing the interference of histamine with intracellular binding sites.	alpha-fluoromethylhistidine	102-110	histidine decarboxylase	Homo sapiens	121-124
12469348-4	2002	(S)-alpha-fluoromethylhistidine, a specific and potent irreversible inhibitor of HDC, was also very useful in studies on functions of the neuron system.	alpha-fluoromethylhistidine	0-31	histidine decarboxylase	Homo sapiens	81-84
11557529-6	2001	Experiments employing specific histamine receptor agonists indicated that the inhibitory effect was not dependent on histamine production, and studies with the HDC inhibitor alpha-fluoromethylhistidine revealed that inhibition was unrelated to enzyme activity.	alpha-fluoromethylhistidine	174-201	histidine decarboxylase	Rattus norvegicus	160-163
11788786-5	2002	Pretreatment of the rats with an ip bolus injection of alpha-fluoromethylhistidine, a suicide inhibitor of a histidine decarboxylase (HDC), at a dosage of 224 micromol/kg blocked the conversion of histidine into histamine and attenuated the suppressive effect of histidine on food intake from 64.2% to 88.1% of the controls (P < 0.05).	alpha-fluoromethylhistidine	55-82	histidine decarboxylase	Rattus norvegicus	109-132
11788786-5	2002	Pretreatment of the rats with an ip bolus injection of alpha-fluoromethylhistidine, a suicide inhibitor of a histidine decarboxylase (HDC), at a dosage of 224 micromol/kg blocked the conversion of histidine into histamine and attenuated the suppressive effect of histidine on food intake from 64.2% to 88.1% of the controls (P < 0.05).	alpha-fluoromethylhistidine	55-82	histidine decarboxylase	Rattus norvegicus	134-137
11246041-6	2001	Depletion of histamine by alpha-fluoromethylhistidine (an irreversible inhibitor of HDC) prevents gastrin-induced but not histamine-induced gastric acid secretion.	alpha-fluoromethylhistidine	26-53	histidine decarboxylase	Homo sapiens	84-87
11246041-6	2001	Depletion of histamine by alpha-fluoromethylhistidine (an irreversible inhibitor of HDC) prevents gastrin-induced but not histamine-induced gastric acid secretion.	alpha-fluoromethylhistidine	26-53	gastrin	Homo sapiens	98-105
10672910-12	2000	Depletion of ECL-cell histamine by alpha-fluoromethylhistidine, an irreversible inhibitor of the histamine-forming enzyme, suppressed the gastrin-evoked release of histamine but not that of pancreastatin.	alpha-fluoromethylhistidine	35-62	gastrin	Rattus norvegicus	138-145
11163292-5	2001	The effect of S+alpha-fluoromethylhistidine, a specific inhibitor of histidine decarboxylase, applied in a lateral ventricle was comparable to the effect of pyrilamine on polypnea.	alpha-fluoromethylhistidine	14-43	histidine decarboxylase	Oryctolagus cuniculus	69-92
10913579-3	2000	alpha-Fluoromethylhistidine, an irreversible inhibitor of the histamine-forming enzyme, histidine decarboxylase depletes ECL-cell but not mast-cell histamine.	alpha-fluoromethylhistidine	0-27	histidine decarboxylase	Rattus norvegicus	88-111
10913579-5	2000	Rats received alpha-fluoromethylhistidine by continuous subcutaneous infusion for 24 h. Maximally effective doses (>/=3 mg/kg/h) inhibited histidine decarboxylase and reduced oxyntic mucosal histamine in fed rats by 80-90%.	alpha-fluoromethylhistidine	14-41	histidine decarboxylase	Rattus norvegicus	142-165
10913579-9	2000	The amount of histamine secreted in response to gastrin (monitored by gastric submucosal microdialysis) was greatly reduced by alpha-fluoromethylhistidine in fed rats but not in fasted rats.	alpha-fluoromethylhistidine	127-154	gastrin	Rattus norvegicus	48-55
10913579-12	2000	In a medium containing 10 nM gastrin, ECL cells responded to a maximally effective concentration of alpha-fluoromethylhistidine (0.1 nM) with 80% reduction in histamine content.	alpha-fluoromethylhistidine	100-127	gastrin	Rattus norvegicus	29-36
10893046-7	2000	This activity was completely inhibited by (S)-alpha-fluoromethylhistidine, a specific inhibitor of HDC.	alpha-fluoromethylhistidine	42-73	histidine decarboxylase	Rattus norvegicus	99-102
10672910-14	2000	We conclude that histamine mobilized by gastrin and food intake derives from ECL cells because: 1) Histamine and pancreastatin were released concomitantly, 2) histamine mobilization following gastrin or food intake was prevented by gastrin receptor blockade, and 3) mobilization of histamine (but not pancreastatin) was abolished by alpha-fluoromethylhistidine.	alpha-fluoromethylhistidine	333-360	gastrin	Rattus norvegicus	40-47
10672910-14	2000	We conclude that histamine mobilized by gastrin and food intake derives from ECL cells because: 1) Histamine and pancreastatin were released concomitantly, 2) histamine mobilization following gastrin or food intake was prevented by gastrin receptor blockade, and 3) mobilization of histamine (but not pancreastatin) was abolished by alpha-fluoromethylhistidine.	alpha-fluoromethylhistidine	333-360	gastrin	Rattus norvegicus	192-199
10672910-14	2000	We conclude that histamine mobilized by gastrin and food intake derives from ECL cells because: 1) Histamine and pancreastatin were released concomitantly, 2) histamine mobilization following gastrin or food intake was prevented by gastrin receptor blockade, and 3) mobilization of histamine (but not pancreastatin) was abolished by alpha-fluoromethylhistidine.	alpha-fluoromethylhistidine	333-360	gastrin	Rattus norvegicus	192-199
10604837-6	1999	administration of alpha-fluoromethylhistidine (FMH), a specific and irreversible inhibitor of histidine decarboxylase, on leptin-induced suppression of food intake in normal C57BL strain mice.	alpha-fluoromethylhistidine	18-45	histidine decarboxylase	Mus musculus	94-117
10711350-6	2000	alpha-Fluoromethylhistidine, a suicide substrate of L-histidine decarboxylase (HDC), suppressed the thapsigargin (30 nM)- and TPA (30 nM)-induced histamine production.	alpha-fluoromethylhistidine	0-27	histidine decarboxylase	Mus musculus	52-77
10711350-6	2000	alpha-Fluoromethylhistidine, a suicide substrate of L-histidine decarboxylase (HDC), suppressed the thapsigargin (30 nM)- and TPA (30 nM)-induced histamine production.	alpha-fluoromethylhistidine	0-27	histidine decarboxylase	Mus musculus	79-82
10580415-7	1999	Systemic depletion of brain histamine levels by pretreatment with an intraperitoneal injection of 224 micromol/kg alpha-fluoromethylhistidine (FMH), a suicide inhibitor of HDC, attenuated the leptin-induced feeding suppression by 50.7% (P < 0.05).	alpha-fluoromethylhistidine	114-141	histidine decarboxylase	Rattus norvegicus	172-175
10580415-7	1999	Systemic depletion of brain histamine levels by pretreatment with an intraperitoneal injection of 224 micromol/kg alpha-fluoromethylhistidine (FMH), a suicide inhibitor of HDC, attenuated the leptin-induced feeding suppression by 50.7% (P < 0.05).	alpha-fluoromethylhistidine	114-141	leptin	Rattus norvegicus	192-198
10580415-7	1999	Systemic depletion of brain histamine levels by pretreatment with an intraperitoneal injection of 224 micromol/kg alpha-fluoromethylhistidine (FMH), a suicide inhibitor of HDC, attenuated the leptin-induced feeding suppression by 50.7% (P < 0.05).	alpha-fluoromethylhistidine	143-146	histidine decarboxylase	Rattus norvegicus	172-175
10580415-7	1999	Systemic depletion of brain histamine levels by pretreatment with an intraperitoneal injection of 224 micromol/kg alpha-fluoromethylhistidine (FMH), a suicide inhibitor of HDC, attenuated the leptin-induced feeding suppression by 50.7% (P < 0.05).	alpha-fluoromethylhistidine	143-146	leptin	Rattus norvegicus	192-198
10604837-6	1999	administration of alpha-fluoromethylhistidine (FMH), a specific and irreversible inhibitor of histidine decarboxylase, on leptin-induced suppression of food intake in normal C57BL strain mice.	alpha-fluoromethylhistidine	47-50	histidine decarboxylase	Mus musculus	94-117
9579727-16	1998	The effect of 500 mg kg(-1) L-histidine was completely prevented by the selective histidine decarboxylase inhibitor, (S)-alpha-fluoromethylhistidine (50 mg kg(-1), i.p.	alpha-fluoromethylhistidine	117-148	histidine decarboxylase	Mus musculus	82-105
10408253-9	1999	Excitatory effects of CCK-8S and gastrin-I were not modified by vagotomy or atropine, whereas cimetidine or alpha-fluoromethylhistidine (irreversible blocker of histidine decarboxylase) partly prevented acid hypersecretion induced by both peptides without affecting their pepsigogue effects.	alpha-fluoromethylhistidine	108-135	histidine decarboxylase	Rattus norvegicus	161-184
9831923-9	1998	An irreversible inhibitor of HDC, alpha-fluoromethylhistidine, partially inhibited the accumulation in the later period.	alpha-fluoromethylhistidine	34-61	histidine decarboxylase	Mus musculus	29-32
10461351-4	1998	Following depletion of ECL-cell histamine by treatment with alpha-fluoromethylhistidine (alpha-FMH), basal acid secretion was reduced, and gastrin-stimulated acid secretion was abolished.	alpha-fluoromethylhistidine	60-87	gastrin	Homo sapiens	139-146
10461351-4	1998	Following depletion of ECL-cell histamine by treatment with alpha-fluoromethylhistidine (alpha-FMH), basal acid secretion was reduced, and gastrin-stimulated acid secretion was abolished.	alpha-fluoromethylhistidine	89-98	gastrin	Homo sapiens	139-146
9098789-0	1997	alpha-Fluoromethylhistidine elevates histidine decarboxylase mRNA and chromogranin A mRNA levels in rat oxyntic mucosa.	alpha-fluoromethylhistidine	0-27	histidine decarboxylase	Rattus norvegicus	37-60
9452148-2	1998	The depletion of neuronal histamine (HA) from the Me5 by the bilateral microinfusion of 448 nmol/rat alpha-fluoromethylhistidine (FMH), a specific suicide inhibitor of histidine decarboxylase, reduced the eating speed and prolonged meal duration, while leaving the meal size unaffected.	alpha-fluoromethylhistidine	101-128	histidine decarboxylase	Rattus norvegicus	168-191
9452148-2	1998	The depletion of neuronal histamine (HA) from the Me5 by the bilateral microinfusion of 448 nmol/rat alpha-fluoromethylhistidine (FMH), a specific suicide inhibitor of histidine decarboxylase, reduced the eating speed and prolonged meal duration, while leaving the meal size unaffected.	alpha-fluoromethylhistidine	130-133	histidine decarboxylase	Rattus norvegicus	168-191
9515556-1	1998	We examined the effects of repeated administration of (S)-alpha-fluoromethylhistidine (FMH), a specific inhibitor of histidine decarboxylase (HDC), on radial maze performance and brain contents of histamine and amino acids in rats.	alpha-fluoromethylhistidine	54-85	histidine decarboxylase	Rattus norvegicus	117-140
9515556-1	1998	We examined the effects of repeated administration of (S)-alpha-fluoromethylhistidine (FMH), a specific inhibitor of histidine decarboxylase (HDC), on radial maze performance and brain contents of histamine and amino acids in rats.	alpha-fluoromethylhistidine	54-85	histidine decarboxylase	Rattus norvegicus	142-145
9515556-1	1998	We examined the effects of repeated administration of (S)-alpha-fluoromethylhistidine (FMH), a specific inhibitor of histidine decarboxylase (HDC), on radial maze performance and brain contents of histamine and amino acids in rats.	alpha-fluoromethylhistidine	87-90	histidine decarboxylase	Rattus norvegicus	117-140
9515556-1	1998	We examined the effects of repeated administration of (S)-alpha-fluoromethylhistidine (FMH), a specific inhibitor of histidine decarboxylase (HDC), on radial maze performance and brain contents of histamine and amino acids in rats.	alpha-fluoromethylhistidine	87-90	histidine decarboxylase	Rattus norvegicus	142-145
9654597-5	1998	By inhibiting the HDC enzyme activity by FMH and blocking the intracellular action of histamine by DPPE, a significant decrease in cell proliferation was observed in mitogen stimulated lymphocytes of healthy donors.	alpha-fluoromethylhistidine	41-44	histidine decarboxylase	Homo sapiens	18-21
9098789-0	1997	alpha-Fluoromethylhistidine elevates histidine decarboxylase mRNA and chromogranin A mRNA levels in rat oxyntic mucosa.	alpha-fluoromethylhistidine	0-27	chromogranin A	Rattus norvegicus	70-84
9062867-6	1997	The detected enzyme activities were sensitive to specific inhibitors of HDC (alpha-fluoromethylhistidine and alpha-hydrazinohistidine) and HMT (quinacrine and metoprine); inhibitors of aromatic amino acid decarboxylase alpha-methyl-DOPA and NSD-1015 were inactive on HDC.	alpha-fluoromethylhistidine	77-104	histidine decarboxylase	Gallus gallus	72-75
9062867-6	1997	The detected enzyme activities were sensitive to specific inhibitors of HDC (alpha-fluoromethylhistidine and alpha-hydrazinohistidine) and HMT (quinacrine and metoprine); inhibitors of aromatic amino acid decarboxylase alpha-methyl-DOPA and NSD-1015 were inactive on HDC.	alpha-fluoromethylhistidine	77-104	histidine decarboxylase	Gallus gallus	267-270
8750797-5	1995	This ameliorating effect of histidine was abolished by alpha-fluoromethylhistidine, an inhibitor of histidine decarboxylase, suggesting that histidine itself has no such ameliorating effect.	alpha-fluoromethylhistidine	55-82	histidine decarboxylase	Mus musculus	100-123
8929340-5	1996	alpha-Fluoromethylhistidine is an irreversible inhibitor of histidine decarboxylase, the histamine-forming enzyme.	alpha-fluoromethylhistidine	0-27	histidine decarboxylase	Rattus norvegicus	60-83
8958779-3	1996	Daily injection of alpha-FMH (20 mg/kg, s.c.) in pups of either sex, from birth until 10 days of age, caused a significant increase in baseline plasma GH and potentiated the GH response to the [Met5]-enkephalin analog FK 33-824 (1 mg/kg, s.c.) administered 3 h after the last alpha-FMH injection.	alpha-fluoromethylhistidine	19-28	proenkephalin	Rattus norvegicus	200-210
8958779-6	1996	Repeated administration of alpha-FMH (200 micrograms/rat, i.c.v., for 3 days) failed to modify basal and FK 33-824-induced GH secretion, caused a significant reduction in hypothalamic GHRH mRNA levels and left SRIF and GH mRNAs unchanged.	alpha-fluoromethylhistidine	27-36	growth hormone releasing hormone	Rattus norvegicus	184-188
8938662-1	1996	In this study we assessed the cardiovascular response to 13 days of irreversible inhibition of the enzyme histidine-decarboxylase (HD) with alpha-fluoro-methylhistidine (AFMH).	alpha-fluoromethylhistidine	140-168	histidine decarboxylase	Rattus norvegicus	106-129
8938662-1	1996	In this study we assessed the cardiovascular response to 13 days of irreversible inhibition of the enzyme histidine-decarboxylase (HD) with alpha-fluoro-methylhistidine (AFMH).	alpha-fluoromethylhistidine	170-174	histidine decarboxylase	Rattus norvegicus	106-129
8898415-2	1996	We have studied how histamine depletion by subcutaneous infusion of the HDC inhibitor alpha-fluoromethyl-histidine (alpha-FMH) affects how ECL cells respond to hypergastrinemia in terms of HDC and CGA mRNA levels.	alpha-fluoromethylhistidine	86-114	histidine decarboxylase	Rattus norvegicus	72-75
8898415-2	1996	We have studied how histamine depletion by subcutaneous infusion of the HDC inhibitor alpha-fluoromethyl-histidine (alpha-FMH) affects how ECL cells respond to hypergastrinemia in terms of HDC and CGA mRNA levels.	alpha-fluoromethylhistidine	86-114	histidine decarboxylase	Rattus norvegicus	189-192
8898415-2	1996	We have studied how histamine depletion by subcutaneous infusion of the HDC inhibitor alpha-fluoromethyl-histidine (alpha-FMH) affects how ECL cells respond to hypergastrinemia in terms of HDC and CGA mRNA levels.	alpha-fluoromethylhistidine	86-114	chromogranin A	Rattus norvegicus	197-200
8898415-2	1996	We have studied how histamine depletion by subcutaneous infusion of the HDC inhibitor alpha-fluoromethyl-histidine (alpha-FMH) affects how ECL cells respond to hypergastrinemia in terms of HDC and CGA mRNA levels.	alpha-fluoromethylhistidine	116-125	histidine decarboxylase	Rattus norvegicus	72-75
8898415-2	1996	We have studied how histamine depletion by subcutaneous infusion of the HDC inhibitor alpha-fluoromethyl-histidine (alpha-FMH) affects how ECL cells respond to hypergastrinemia in terms of HDC and CGA mRNA levels.	alpha-fluoromethylhistidine	116-125	chromogranin A	Rattus norvegicus	197-200
8898415-5	1996	RESULTS: alpha-FMH for 24 h increased the HDC and CGA mRNA levels without increasing the serum gastrin concentration.	alpha-fluoromethylhistidine	9-18	histidine decarboxylase	Rattus norvegicus	42-45
8898415-5	1996	RESULTS: alpha-FMH for 24 h increased the HDC and CGA mRNA levels without increasing the serum gastrin concentration.	alpha-fluoromethylhistidine	9-18	chromogranin A	Rattus norvegicus	50-53
8898415-6	1996	alpha-FMH for 10 days increased the serum gastrin concentration twofold.	alpha-fluoromethylhistidine	0-9	gastrin	Rattus norvegicus	42-49
8898415-7	1996	alpha-FMH + omeprazole resulted in the same serum gastrin concentration as after omeprazole alone (eightfold increase).	alpha-fluoromethylhistidine	0-9	gastrin	Rattus norvegicus	50-57
8898415-8	1996	HDC mRNA levels were higher after alpha-FMH + omeprazole than after omeprazole alone.	alpha-fluoromethylhistidine	34-43	histidine decarboxylase	Rattus norvegicus	0-3
8898415-9	1996	alpha-FMH alone induced an HDC mRNA level that was similar in magnitude to that observed after omeprazole, although the serum gastrin concentration after alpha-FMH was much lower.	alpha-fluoromethylhistidine	0-9	histidine decarboxylase	Rattus norvegicus	27-30
8898415-9	1996	alpha-FMH alone induced an HDC mRNA level that was similar in magnitude to that observed after omeprazole, although the serum gastrin concentration after alpha-FMH was much lower.	alpha-fluoromethylhistidine	154-163	gastrin	Rattus norvegicus	126-133
8898415-10	1996	In antrectomized rats alpha-FMH increased the HDC and CGA mRNA levels without increasing the serum gastrin concentration.	alpha-fluoromethylhistidine	22-31	histidine decarboxylase	Rattus norvegicus	46-49
8898415-10	1996	In antrectomized rats alpha-FMH increased the HDC and CGA mRNA levels without increasing the serum gastrin concentration.	alpha-fluoromethylhistidine	22-31	chromogranin A	Rattus norvegicus	54-57
8884980-9	1996	alpha-FMH reduced gastrin-evoked histamine outflow but did not affect gastrin-evoked pancreastatin-LI outflow.	alpha-fluoromethylhistidine	0-9	gastrin	Rattus norvegicus	18-25
8884980-10	1996	Also the acid output in response to gastrin + IBMX was much reduced by alpha-FMH.	alpha-fluoromethylhistidine	71-80	gastrin	Rattus norvegicus	36-43
8630521-10	1996	In rats treated with alpha-fluoromethylhistidine, an inhibitor of L-histidine decarboxylase, the cold-induced (rats kept for 60 min at +4 degrees C) thyrotropin secretion was increased while the stress-induced prolactin secretion was decreased.	alpha-fluoromethylhistidine	21-48	prolactin	Rattus norvegicus	210-219
8788860-1	1995	We examined the long-term effects of administration of (S)-alpha-fluoromethylhistidine (FMH), a specific inhibitor of histidine decarboxylase, on the spontaneous locomotor activity, food intake and brain contents of histamine, catecholamines, serotonin and amino acids of ICR mice.	alpha-fluoromethylhistidine	55-86	histidine decarboxylase	Mus musculus	118-141
8594930-3	1995	However, depletion of neuronal histamine induced by intraperitoneal injection of 160 mumol/rat alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase (HDC), attenuated the suppressive effect of IL-1 beta on food intake, facilitated the suppressive effect on drinking, and enhanced the elevating effect on rectal temperature.	alpha-fluoromethylhistidine	95-122	histidine decarboxylase	Rattus norvegicus	147-170
8594930-3	1995	However, depletion of neuronal histamine induced by intraperitoneal injection of 160 mumol/rat alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase (HDC), attenuated the suppressive effect of IL-1 beta on food intake, facilitated the suppressive effect on drinking, and enhanced the elevating effect on rectal temperature.	alpha-fluoromethylhistidine	95-122	histidine decarboxylase	Rattus norvegicus	172-175
8594930-3	1995	However, depletion of neuronal histamine induced by intraperitoneal injection of 160 mumol/rat alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase (HDC), attenuated the suppressive effect of IL-1 beta on food intake, facilitated the suppressive effect on drinking, and enhanced the elevating effect on rectal temperature.	alpha-fluoromethylhistidine	95-122	interleukin 1 beta	Rattus norvegicus	215-224
8653552-3	1995	Depletion of neuronal histamine in the hypothalamus induced by alpha-fluoromethylhistidine, a suicide inhibitor of the histamine synthesizing enzyme histidine decarboxylase (HDC), attenuated the suppressive effect of IL-1 beta on food intake, facilitated the inhibitory effect on water intake, and enhanced its thermogenic effect.	alpha-fluoromethylhistidine	63-90	histidine decarboxylase	Rattus norvegicus	149-172
8653552-3	1995	Depletion of neuronal histamine in the hypothalamus induced by alpha-fluoromethylhistidine, a suicide inhibitor of the histamine synthesizing enzyme histidine decarboxylase (HDC), attenuated the suppressive effect of IL-1 beta on food intake, facilitated the inhibitory effect on water intake, and enhanced its thermogenic effect.	alpha-fluoromethylhistidine	63-90	histidine decarboxylase	Rattus norvegicus	174-177
8653552-3	1995	Depletion of neuronal histamine in the hypothalamus induced by alpha-fluoromethylhistidine, a suicide inhibitor of the histamine synthesizing enzyme histidine decarboxylase (HDC), attenuated the suppressive effect of IL-1 beta on food intake, facilitated the inhibitory effect on water intake, and enhanced its thermogenic effect.	alpha-fluoromethylhistidine	63-90	interleukin 1 beta	Rattus norvegicus	217-226
7720459-6	1995	The increase of ornithine decarboxylase activity was attenuated when the increase of histamine synthesis was suppressed by the inhibition of histidine decarboxylase activity caused by pretreatment with alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase.	alpha-fluoromethylhistidine	202-229	ornithine decarboxylase 1	Rattus norvegicus	16-39
7542315-7	1995	Next, the effects of (S) alpha-fluoromethylhistidine (FMH), a specific inhibitor of HDC, on the histamine contents and HDC activities of various regions of the brain were examined in Ws/Ws rats.	alpha-fluoromethylhistidine	54-57	histidine decarboxylase	Rattus norvegicus	119-122
7586491-9	1995	Administration of (S) alpha-fluoromethylhistidine (FMH), a specific inhibitor of L-histidine decarboxylase (HDC), significantly decreased both the HDC activity and histamine concentration during postnatal development.	alpha-fluoromethylhistidine	22-49	histidine decarboxylase	Rattus norvegicus	81-106
7586491-9	1995	Administration of (S) alpha-fluoromethylhistidine (FMH), a specific inhibitor of L-histidine decarboxylase (HDC), significantly decreased both the HDC activity and histamine concentration during postnatal development.	alpha-fluoromethylhistidine	22-49	histidine decarboxylase	Rattus norvegicus	108-111
7586491-9	1995	Administration of (S) alpha-fluoromethylhistidine (FMH), a specific inhibitor of L-histidine decarboxylase (HDC), significantly decreased both the HDC activity and histamine concentration during postnatal development.	alpha-fluoromethylhistidine	22-49	histidine decarboxylase	Rattus norvegicus	147-150
7586491-9	1995	Administration of (S) alpha-fluoromethylhistidine (FMH), a specific inhibitor of L-histidine decarboxylase (HDC), significantly decreased both the HDC activity and histamine concentration during postnatal development.	alpha-fluoromethylhistidine	51-54	histidine decarboxylase	Rattus norvegicus	81-106
7586491-9	1995	Administration of (S) alpha-fluoromethylhistidine (FMH), a specific inhibitor of L-histidine decarboxylase (HDC), significantly decreased both the HDC activity and histamine concentration during postnatal development.	alpha-fluoromethylhistidine	51-54	histidine decarboxylase	Rattus norvegicus	108-111
7586491-9	1995	Administration of (S) alpha-fluoromethylhistidine (FMH), a specific inhibitor of L-histidine decarboxylase (HDC), significantly decreased both the HDC activity and histamine concentration during postnatal development.	alpha-fluoromethylhistidine	51-54	histidine decarboxylase	Rattus norvegicus	147-150
7720668-6	1995	Pretreatment with the HA synthesis inhibitor alpha-fluoromethylhistidine (alpha FMH) increased the expression of HDC mRNA in 24-h dehydrated rats, but had no effect in euhydrated rats.	alpha-fluoromethylhistidine	45-72	histidine decarboxylase	Rattus norvegicus	113-116
7720668-6	1995	Pretreatment with the HA synthesis inhibitor alpha-fluoromethylhistidine (alpha FMH) increased the expression of HDC mRNA in 24-h dehydrated rats, but had no effect in euhydrated rats.	alpha-fluoromethylhistidine	74-83	histidine decarboxylase	Rattus norvegicus	113-116
7536939-3	1995	We examined the effect of alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase, on ornithine decarboxylase activity after ischemia-reperfusion and compared this with its effect on the rat after refeeding.	alpha-fluoromethylhistidine	26-53	histidine decarboxylase	Rattus norvegicus	78-101
7536939-3	1995	We examined the effect of alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase, on ornithine decarboxylase activity after ischemia-reperfusion and compared this with its effect on the rat after refeeding.	alpha-fluoromethylhistidine	26-53	ornithine decarboxylase 1	Rattus norvegicus	106-129
7536939-7	1995	Ornithine decarboxylase activity increased markedly 3 and 6 hr after ischemia-reperfusion and refeeding, whereas alpha-fluoromethylhistidine attenuated the increase in ornithine decarboxylase activity only in the ischemia-reperfusion group.	alpha-fluoromethylhistidine	113-140	ornithine decarboxylase 1	Rattus norvegicus	168-191
7720459-6	1995	The increase of ornithine decarboxylase activity was attenuated when the increase of histamine synthesis was suppressed by the inhibition of histidine decarboxylase activity caused by pretreatment with alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase.	alpha-fluoromethylhistidine	202-229	histidine decarboxylase	Rattus norvegicus	141-164
7720459-6	1995	The increase of ornithine decarboxylase activity was attenuated when the increase of histamine synthesis was suppressed by the inhibition of histidine decarboxylase activity caused by pretreatment with alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase.	alpha-fluoromethylhistidine	202-229	histidine decarboxylase	Rattus norvegicus	254-277
7774858-7	1995	Alpha-fluoromethylhistidine, a suicide inhibitor of HDC, suppressed LPS-induced cytokine production.	alpha-fluoromethylhistidine	0-27	histidine decarboxylase	Mus musculus	52-55
7796129-5	1995	On the other hand, the histidine decarboxylase inhibitor, alpha-fluoromethylhistidine (alpha-FMH), significantly potentiated the morphine (1 mg/kg)-induced place preference.	alpha-fluoromethylhistidine	58-85	histidine decarboxylase	Mus musculus	23-46
7796129-5	1995	On the other hand, the histidine decarboxylase inhibitor, alpha-fluoromethylhistidine (alpha-FMH), significantly potentiated the morphine (1 mg/kg)-induced place preference.	alpha-fluoromethylhistidine	87-96	histidine decarboxylase	Mus musculus	23-46
7882040-0	1994	Histamine depletion in brain caused by treatment with (S)alpha-fluoromethylhistidine enhances ischemic damage of gerbil hippocampal CA2 neurons.	alpha-fluoromethylhistidine	54-84	carbonic anhydrase 2	Homo sapiens	132-135
7664030-0	1995	Effects of histamine and alpha-fluoromethylhistidine on brain tumor necrosis factor levels in rats.	alpha-fluoromethylhistidine	25-52	tumor necrosis factor-like	Rattus norvegicus	62-83
7664030-4	1995	administrations of HA diphosphate (6 mumol/kg) and alpha-fluoromethylhistidine (FMH; 100 mg/kg) on TNF-alpha levels in the hippocampus, hypothalamus, and posterior hypothalamic region of the rat brain.	alpha-fluoromethylhistidine	51-78	tumor necrosis factor	Rattus norvegicus	99-108
7664030-4	1995	administrations of HA diphosphate (6 mumol/kg) and alpha-fluoromethylhistidine (FMH; 100 mg/kg) on TNF-alpha levels in the hippocampus, hypothalamus, and posterior hypothalamic region of the rat brain.	alpha-fluoromethylhistidine	80-83	tumor necrosis factor	Rattus norvegicus	99-108
7664030-7	1995	Three hours after FMH administration, an increase in the hippocampal levels of TNF-alpha was observed (0.43 +/- 0.04 pg/mg; p < 0.01), while in the hypothalamus (0.11 +/- 0.02 pg/mg; p < 0.01) and in the posterior hypothalamic region (0.21 +/- 0.04 pg/mg; p < 0.05) a decrease in TNF-alpha levels was detected.	alpha-fluoromethylhistidine	18-21	tumor necrosis factor	Rattus norvegicus	79-88
7664030-7	1995	Three hours after FMH administration, an increase in the hippocampal levels of TNF-alpha was observed (0.43 +/- 0.04 pg/mg; p < 0.01), while in the hypothalamus (0.11 +/- 0.02 pg/mg; p < 0.01) and in the posterior hypothalamic region (0.21 +/- 0.04 pg/mg; p < 0.05) a decrease in TNF-alpha levels was detected.	alpha-fluoromethylhistidine	18-21	tumor necrosis factor	Rattus norvegicus	289-298
7882040-3	1994	Neuronal loss in the CA2 region of the hippocampus 7 days after 3 min ischemia was enhanced by treatment with FMH.	alpha-fluoromethylhistidine	110-113	carbonic anhydrase 2	Homo sapiens	21-24
8033816-8	1994	Dehydration-induced AVP secretion was lowered when neuronal HA synthesis was inhibited by the administration of (S) alpha-fluoromethylhistidine or when the animals were pretreated with the H3-receptor agonist R(alpha)methylhistamine, which inhibits the release and synthesis of HA, the H1-receptor antagonists mepyramine and cetirizine, or the H2-receptor antagonists cimetidine and ranitidine.	alpha-fluoromethylhistidine	112-143	arginine vasopressin	Homo sapiens	20-23
8156416-1	1994	Intraperitoneal injection of alpha-fluoromethylhistidine (alpha-FMH; 200 mg/kg), a specific inhibitor of histidine decarboxylase produced a severe depletion of neocortical and hippocampal histamine 3 h later as determined by a radioenzymatic assay.	alpha-fluoromethylhistidine	29-56	histidine decarboxylase	Rattus norvegicus	105-128
8156416-1	1994	Intraperitoneal injection of alpha-fluoromethylhistidine (alpha-FMH; 200 mg/kg), a specific inhibitor of histidine decarboxylase produced a severe depletion of neocortical and hippocampal histamine 3 h later as determined by a radioenzymatic assay.	alpha-fluoromethylhistidine	58-67	histidine decarboxylase	Rattus norvegicus	105-128
7907523-5	1993	of alpha-fluoromethylhistidine (FMH), a specific inhibitor of the HA synthesizing enzyme histidine decarboxylase (HDC), abolished feeding suppression completely.	alpha-fluoromethylhistidine	3-30	histidine decarboxylase	Rattus norvegicus	89-112
8304983-0	1994	alpha-Fluoromethylhistidine-induced inhibition of brain histidine decarboxylase.	alpha-fluoromethylhistidine	0-27	histidine decarboxylase	Rattus norvegicus	56-79
8304983-2	1994	The actions of S-alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of the histamine biosynthetic enzyme histidine decarboxylase (HD), were studied on rat brain HD, as measured by a recently developed CO2-trapping enzymatic method.	alpha-fluoromethylhistidine	15-44	histidine decarboxylase	Rattus norvegicus	115-138
8304983-2	1994	The actions of S-alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of the histamine biosynthetic enzyme histidine decarboxylase (HD), were studied on rat brain HD, as measured by a recently developed CO2-trapping enzymatic method.	alpha-fluoromethylhistidine	46-49	histidine decarboxylase	Rattus norvegicus	115-138
7907523-5	1993	of alpha-fluoromethylhistidine (FMH), a specific inhibitor of the HA synthesizing enzyme histidine decarboxylase (HDC), abolished feeding suppression completely.	alpha-fluoromethylhistidine	3-30	histidine decarboxylase	Rattus norvegicus	114-117
7907523-5	1993	of alpha-fluoromethylhistidine (FMH), a specific inhibitor of the HA synthesizing enzyme histidine decarboxylase (HDC), abolished feeding suppression completely.	alpha-fluoromethylhistidine	32-35	histidine decarboxylase	Rattus norvegicus	89-112
7907523-5	1993	of alpha-fluoromethylhistidine (FMH), a specific inhibitor of the HA synthesizing enzyme histidine decarboxylase (HDC), abolished feeding suppression completely.	alpha-fluoromethylhistidine	32-35	histidine decarboxylase	Rattus norvegicus	114-117
8313152-2	1993	Infusion of alpha-fluoromethylhistidine (FMH), a "suicide" inhibitor of histidine decarboxylase (HDC), into the third cerebroventricle induced feeding in the early light phase when the histamine synthesis was most accelerated.	alpha-fluoromethylhistidine	12-39	histidine decarboxylase	Rattus norvegicus	72-95
8313152-2	1993	Infusion of alpha-fluoromethylhistidine (FMH), a "suicide" inhibitor of histidine decarboxylase (HDC), into the third cerebroventricle induced feeding in the early light phase when the histamine synthesis was most accelerated.	alpha-fluoromethylhistidine	12-39	histidine decarboxylase	Rattus norvegicus	97-100
8313152-2	1993	Infusion of alpha-fluoromethylhistidine (FMH), a "suicide" inhibitor of histidine decarboxylase (HDC), into the third cerebroventricle induced feeding in the early light phase when the histamine synthesis was most accelerated.	alpha-fluoromethylhistidine	41-44	histidine decarboxylase	Rattus norvegicus	72-95
8313152-2	1993	Infusion of alpha-fluoromethylhistidine (FMH), a "suicide" inhibitor of histidine decarboxylase (HDC), into the third cerebroventricle induced feeding in the early light phase when the histamine synthesis was most accelerated.	alpha-fluoromethylhistidine	41-44	histidine decarboxylase	Rattus norvegicus	97-100
1341077-8	1992	Recently, we could show that alpha-fluoromethylhistidine, which is a suicide inhibitor of histidine decarboxylase, effectively depletes the ECL cells of histamine and that the histamine-depleted ECL cells respond to gastrin with hyperplasia in a manner identical to normal ECL cells.	alpha-fluoromethylhistidine	29-56	histidine decarboxylase	Rattus norvegicus	90-113
8415942-5	1993	However, obese Zuckers and histamine depleted rats due to alpha-fluoromethyl-histidine (FMH), a specific "suicide" inhibitor of a histamine synthesizing decarboxylase enzyme (HDC), failed to show this decrease in food intake as adaptive behavior.	alpha-fluoromethylhistidine	88-91	histidine decarboxylase	Rattus norvegicus	175-178
1384983-5	1992	Histamine synthesis was inhibited with alpha-fluoromethylhistidine (3 mg.kg-1.h-1) given via osmotic minipumps over a period of 24 h. The treatment reduced the histidine decarboxylase activity (approximately 20% remaining) and histamine concentration (less than 20% remaining) in the oxyntic mucosa, as well as the intensity of histamine- and chromogranin A-immunostaining in the ECL cells, compared to control rats.	alpha-fluoromethylhistidine	39-66	histidine decarboxylase	Rattus norvegicus	160-183
1341077-8	1992	Recently, we could show that alpha-fluoromethylhistidine, which is a suicide inhibitor of histidine decarboxylase, effectively depletes the ECL cells of histamine and that the histamine-depleted ECL cells respond to gastrin with hyperplasia in a manner identical to normal ECL cells.	alpha-fluoromethylhistidine	29-56	gastrin	Rattus norvegicus	216-223
1729265-5	1992	These increases in HDC activity, and mucosal and lymph histamine levels were suppressed by pretreatment of alpha-fluoromethylhistidine (alpha-FMH), a suicide inhibitor of HDC.	alpha-fluoromethylhistidine	107-134	histidine decarboxylase	Rattus norvegicus	19-22
1499940-7	1992	Treatment with alpha-fluoromethylhistidine plus omeprazole markedly reduced the histidine decarboxylase activity and histamine concentration, but the weight of the stomach and oxyntic mucosa, the enterochromaffinlike cell density, and intensity of histidine decarboxylase immunostaining were increased to at least the same extent as after omeprazole alone.	alpha-fluoromethylhistidine	15-42	histidine decarboxylase	Rattus norvegicus	80-103
1499940-7	1992	Treatment with alpha-fluoromethylhistidine plus omeprazole markedly reduced the histidine decarboxylase activity and histamine concentration, but the weight of the stomach and oxyntic mucosa, the enterochromaffinlike cell density, and intensity of histidine decarboxylase immunostaining were increased to at least the same extent as after omeprazole alone.	alpha-fluoromethylhistidine	15-42	histidine decarboxylase	Rattus norvegicus	248-271
1559640-8	1992	alpha-Fluoromethylhistidine, a specific inhibitor of HDC, is a powerful tool for reducing the neuronal histamine in the brain.	alpha-fluoromethylhistidine	0-27	histidine decarboxylase	Rattus norvegicus	53-56
1729265-5	1992	These increases in HDC activity, and mucosal and lymph histamine levels were suppressed by pretreatment of alpha-fluoromethylhistidine (alpha-FMH), a suicide inhibitor of HDC.	alpha-fluoromethylhistidine	107-134	histidine decarboxylase	Rattus norvegicus	171-174
1729265-5	1992	These increases in HDC activity, and mucosal and lymph histamine levels were suppressed by pretreatment of alpha-fluoromethylhistidine (alpha-FMH), a suicide inhibitor of HDC.	alpha-fluoromethylhistidine	136-145	histidine decarboxylase	Rattus norvegicus	19-22
1729265-5	1992	These increases in HDC activity, and mucosal and lymph histamine levels were suppressed by pretreatment of alpha-fluoromethylhistidine (alpha-FMH), a suicide inhibitor of HDC.	alpha-fluoromethylhistidine	136-145	histidine decarboxylase	Rattus norvegicus	171-174
1664503-5	1991	The two doses of (S)-alpha-fluoromethylhistidine inhibited by 35 and 50% the ACTH response to inhibited the ACTH and alpha-MSH response to ether stress by 50 and 70%, respectively.	alpha-fluoromethylhistidine	17-48	proopiomelanocortin	Rattus norvegicus	117-126
1834679-4	1991	We further provide evidence that this phenomenon is completely abolished: i) by preventing GM-CSF-induced histamine synthesis by alpha-FMH, the specific inhibitor of histidine decarboxylase (HDC), or ii) by blocking the binding sites of H2 histamine receptors with their specific antagonist oxmetidine.	alpha-fluoromethylhistidine	129-138	colony stimulating factor 2	Homo sapiens	91-97
1834679-4	1991	We further provide evidence that this phenomenon is completely abolished: i) by preventing GM-CSF-induced histamine synthesis by alpha-FMH, the specific inhibitor of histidine decarboxylase (HDC), or ii) by blocking the binding sites of H2 histamine receptors with their specific antagonist oxmetidine.	alpha-fluoromethylhistidine	129-138	histidine decarboxylase	Homo sapiens	166-189
1834679-4	1991	We further provide evidence that this phenomenon is completely abolished: i) by preventing GM-CSF-induced histamine synthesis by alpha-FMH, the specific inhibitor of histidine decarboxylase (HDC), or ii) by blocking the binding sites of H2 histamine receptors with their specific antagonist oxmetidine.	alpha-fluoromethylhistidine	129-138	histidine decarboxylase	Homo sapiens	191-194
1865929-2	1991	We investigated the effect of inhibition of histamine synthesis by alpha-fluoromethylhistidine (alpha-FMH), the irreversible inhibitor of histidine decarboxylase, on the development and maintenance of hypertension in spontaneously hypertensive rats.	alpha-fluoromethylhistidine	96-105	histidine decarboxylase	Rattus norvegicus	138-161
1907141-5	1991	S-alpha-Fluoromethylhistidine (FMH) and alpha-hydrazinohistidine, specific inhibitors of HDC, induced concentration-dependent reductions of enzyme activity by up to 90%, whereas inhibitors of other decarboxylases had little or no effect.	alpha-fluoromethylhistidine	0-29	histidine decarboxylase	Rattus norvegicus	89-92
1907141-5	1991	S-alpha-Fluoromethylhistidine (FMH) and alpha-hydrazinohistidine, specific inhibitors of HDC, induced concentration-dependent reductions of enzyme activity by up to 90%, whereas inhibitors of other decarboxylases had little or no effect.	alpha-fluoromethylhistidine	31-34	histidine decarboxylase	Rattus norvegicus	89-92
1897430-0	1991	Histidine decarboxylase inhibition induced by alpha-fluoromethylhistidine provokes learning-related hypokinetic activity.	alpha-fluoromethylhistidine	46-73	histidine decarboxylase	Rattus norvegicus	0-23
1865929-4	1991	Treatment of spontaneously hypertensive rats and normotensive Wistar-Kyoto rats with alpha-fluoromethylhistidine led to a pronounced decrease in the histidine decarboxylase activity and in the histamine concentration in the brain (hypothalamus, brainstem, cortex-midbrain).	alpha-fluoromethylhistidine	85-112	histidine decarboxylase	Rattus norvegicus	149-172
2053511-4	1991	Some functions, including the circadian rhythms, sleep-arousal cycles, drinking, feeding, thermoregulation, and neuroendocrine controls which were elucidated by administration of alpha-fluoromethylhistidine, a suicide substrate for histidine decarboxylase, are discussed here, although the true functions are still under investigations.	alpha-fluoromethylhistidine	179-206	histidine decarboxylase	Rattus norvegicus	232-255
2117926-5	1990	The enzyme was inhibited by alpha-fluoromethylhistidine but not by carbidopa, was unable to form dopamine from L-3,4-dihydroxyphenylalanine, and had a Km value for histidine of 0.27 mM, indicating that it was HDC and not aromatic amino acid decarboxylase.	alpha-fluoromethylhistidine	28-55	histidine decarboxylase	Homo sapiens	209-212
2238092-0	1990	Pharmacology of alpha-fluoromethylhistidine, a specific inhibitor of histidine decarboxylase.	alpha-fluoromethylhistidine	16-43	histidine decarboxylase	Homo sapiens	69-92
2238092-1	1990	alpha-Fluoromethyl-[S]-histidine (FMH) is a specific and potent inhibitor of histidine decarboxylase, which forms histamine from histidine.	alpha-fluoromethylhistidine	34-37	histidine decarboxylase	Homo sapiens	77-100
2182624-2	1990	Mechanism-based inactivation of pyridoxal phosphate-dependent histidine decarboxylase by (S)-alpha-(fluoromethyl)histidine was studied.	alpha-fluoromethylhistidine	89-122	histidine decarboxylase	Homo sapiens	62-85
2325822-5	1990	The partially purified histidine decarboxylase from both sources was dependent on pyridoxal phosphate for maximal activity and was inhibited by alpha-fluoromethylhistidine, nickel chloride and cobaltous chloride but was not inhibited by impromidine, alpha-methyldopa, DTNB, zinc chloride or mercuric chloride.	alpha-fluoromethylhistidine	144-171	histidine decarboxylase	Rattus norvegicus	23-46
2210091-2	1990	This was done by examining the effects of inhibition of the histamine-producing enzyme histidine decarboxylase (HDC) with alpha-fluoromethylhistidine (alpha-FMH) and the effects of degranulation of the mucosal mast cells with dexamethasone.	alpha-fluoromethylhistidine	122-149	histidine decarboxylase	Rattus norvegicus	87-110
2210091-2	1990	This was done by examining the effects of inhibition of the histamine-producing enzyme histidine decarboxylase (HDC) with alpha-fluoromethylhistidine (alpha-FMH) and the effects of degranulation of the mucosal mast cells with dexamethasone.	alpha-fluoromethylhistidine	122-149	histidine decarboxylase	Rattus norvegicus	112-115
2210091-2	1990	This was done by examining the effects of inhibition of the histamine-producing enzyme histidine decarboxylase (HDC) with alpha-fluoromethylhistidine (alpha-FMH) and the effects of degranulation of the mucosal mast cells with dexamethasone.	alpha-fluoromethylhistidine	151-160	histidine decarboxylase	Rattus norvegicus	87-110
2210091-2	1990	This was done by examining the effects of inhibition of the histamine-producing enzyme histidine decarboxylase (HDC) with alpha-fluoromethylhistidine (alpha-FMH) and the effects of degranulation of the mucosal mast cells with dexamethasone.	alpha-fluoromethylhistidine	151-160	histidine decarboxylase	Rattus norvegicus	112-115
2312155-3	1990	Alpha-fluoromethylhistidine, a suicide inhibitor of HDC, attenuated, in a dose-dependent manner, both spontaneous and LPS-stimulated IL-1 synthesis by macrophages.	alpha-fluoromethylhistidine	0-27	histidine decarboxylase	Mus musculus	52-55
2312155-3	1990	Alpha-fluoromethylhistidine, a suicide inhibitor of HDC, attenuated, in a dose-dependent manner, both spontaneous and LPS-stimulated IL-1 synthesis by macrophages.	alpha-fluoromethylhistidine	0-27	interleukin 1 complex	Mus musculus	133-137
35429681-11	2022	This beneficial effect of histidine on memory was cancelled by intracerebroventricular injection of the HDC inhibitor alpha-fluoromethylhistidine.	alpha-fluoromethylhistidine	118-145	histidine decarboxylase	Mus musculus	104-107
2774643-1	1989	Alpha-fluoromethylhistidine (alpha-FMH), a new irreversible inhibitor of mammalian histidine decarboxylase, was tested in the treatment of idiopathic cold urticaria in 11 patients.	alpha-fluoromethylhistidine	0-27	histidine decarboxylase	Homo sapiens	83-106
2615053-2	1989	), a specific inhibitor of histidine decarboxylase, on the presumption that alpha-FMH depletable HA pools represent neuronal ones.	alpha-fluoromethylhistidine	76-85	histidine decarboxylase	Rattus norvegicus	27-50
2505088-6	1989	injections of 10 and 5 mg/kg of propranolol and the cardioselective beta 1-adrenoceptor antagonist metoprolol almost completely inhibited the alpha-FMH-induced histamine decrease.	alpha-fluoromethylhistidine	142-151	adrenoceptor beta 1	Rattus norvegicus	68-87
2750595-2	1989	Although pre-exposure to alpha-fluoromethyl histidine (FMH), an inhibitor of histidine decarboxylase, prevented the effect of AD in vivo and in vitro, this compound was also found to inhibit mast cell granule swelling evoked by AD, a response linked to histamine changes.	alpha-fluoromethylhistidine	25-53	histidine decarboxylase	Rattus norvegicus	77-100
2750595-2	1989	Although pre-exposure to alpha-fluoromethyl histidine (FMH), an inhibitor of histidine decarboxylase, prevented the effect of AD in vivo and in vitro, this compound was also found to inhibit mast cell granule swelling evoked by AD, a response linked to histamine changes.	alpha-fluoromethylhistidine	55-58	histidine decarboxylase	Rattus norvegicus	77-100
2470944-3	1989	The HA turnover, measured either by the accumulation of t-MH after pargyline injection or by the HA depletion after the treatment with alpha-fluoromethylhistidine, a specific inhibitor of histidine decarboxylase, was enhanced by the exposure to tail pinch, like the enhancement produced by the exposure to foot shock.	alpha-fluoromethylhistidine	135-162	histidine decarboxylase	Mus musculus	188-211
2774643-1	1989	Alpha-fluoromethylhistidine (alpha-FMH), a new irreversible inhibitor of mammalian histidine decarboxylase, was tested in the treatment of idiopathic cold urticaria in 11 patients.	alpha-fluoromethylhistidine	29-38	histidine decarboxylase	Homo sapiens	83-106
2803701-10	1989	Rats that received FMH or the combined administration of the histamine antagonists the prolactin and LH surge were abolished (Experiment 2).	alpha-fluoromethylhistidine	19-22	prolactin	Rattus norvegicus	87-96
2803701-11	1989	Only the treatment of the H 2-histamine agonist was able to reproduce the prolactin increase in rats treated with FMH.	alpha-fluoromethylhistidine	114-117	prolactin	Rattus norvegicus	74-83
3136625-0	1988	Long-term depletion of histamine in guinea-pigs by administration of alpha-fluoromethylhistidine, a specific inhibitor of histidine decarboxylase; effect on the sensitivity of histamine receptors.	alpha-fluoromethylhistidine	69-96	histidine decarboxylase	Cavia porcellus	122-145
2464390-3	1988	The K+-evoked release of [3H]-histamine was attenuated by incubation in calcium-free medium and prevented by prior incubation of brain slices with the selective histidine decarboxylase inhibitor S-(alpha)-fluoromethylhistidine.	alpha-fluoromethylhistidine	195-226	histidine decarboxylase	Rattus norvegicus	161-184
3136625-1	1988	The effect of intraperitoneal administration of alpha-fluoromethylhistidine (alpha-FMH), a specific inhibitor of histidine decarboxylase, at a dose of 100 mg/kg twice a day for 6 weeks on the sensitivity of histamine receptors in the guinea-pigs was examined.	alpha-fluoromethylhistidine	48-75	histidine decarboxylase	Cavia porcellus	113-136
3136625-1	1988	The effect of intraperitoneal administration of alpha-fluoromethylhistidine (alpha-FMH), a specific inhibitor of histidine decarboxylase, at a dose of 100 mg/kg twice a day for 6 weeks on the sensitivity of histamine receptors in the guinea-pigs was examined.	alpha-fluoromethylhistidine	77-86	histidine decarboxylase	Cavia porcellus	113-136
3035409-9	1987	When alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase, was administered at doses of 100 mg/kg/day (i.p.	alpha-fluoromethylhistidine	34-37	histidine decarboxylase	Rattus norvegicus	69-92
2838862-1	1988	The effect of alpha-fluoromethylhistidine (alpha-FMH), a specific inhibitor of histidine decarboxylase, on the potentiation of thiopental-induced sleep by delta 9-tetrahydrocannabinol (THC), which inhibits the histamine turnover in the brain, was examined in mice and rats.	alpha-fluoromethylhistidine	14-41	histidine decarboxylase	Mus musculus	79-102
2838862-1	1988	The effect of alpha-fluoromethylhistidine (alpha-FMH), a specific inhibitor of histidine decarboxylase, on the potentiation of thiopental-induced sleep by delta 9-tetrahydrocannabinol (THC), which inhibits the histamine turnover in the brain, was examined in mice and rats.	alpha-fluoromethylhistidine	43-52	histidine decarboxylase	Mus musculus	79-102
2824613-3	1987	Histidine-free culture conditions or addition of alpha-fluoromethylhistidine, an irreversible inhibitor of histidine decarboxylase, completely abrogate this phenomenon, indicating that increased histamine levels result from an augmentation of the rate of its synthesis.	alpha-fluoromethylhistidine	49-76	histidine decarboxylase	Mus musculus	107-130
3685079-1	1987	We examined the ability of two specific inhibitors of histidine decarboxylase, (s)-alpha-fluoromethylhistidine (FMHd) and (s)-alpha-fluoromethylhistamine (FMHm), to inhibit basal gastric acid secretion.	alpha-fluoromethylhistidine	79-110	histidine decarboxylase	Rattus norvegicus	54-77
3685079-1	1987	We examined the ability of two specific inhibitors of histidine decarboxylase, (s)-alpha-fluoromethylhistidine (FMHd) and (s)-alpha-fluoromethylhistamine (FMHm), to inhibit basal gastric acid secretion.	alpha-fluoromethylhistidine	112-116	histidine decarboxylase	Rattus norvegicus	54-77
3604804-1	1987	We investigated whether inhibition of brain histamine (HA) synthesis by alpha-fluoromethylhistidine (alpha-FMH) can influence basal or stimulated prolactin (PRL) release in male rats.	alpha-fluoromethylhistidine	72-99	prolactin	Rattus norvegicus	146-155
3604804-1	1987	We investigated whether inhibition of brain histamine (HA) synthesis by alpha-fluoromethylhistidine (alpha-FMH) can influence basal or stimulated prolactin (PRL) release in male rats.	alpha-fluoromethylhistidine	72-99	prolactin	Rattus norvegicus	157-160
3604804-1	1987	We investigated whether inhibition of brain histamine (HA) synthesis by alpha-fluoromethylhistidine (alpha-FMH) can influence basal or stimulated prolactin (PRL) release in male rats.	alpha-fluoromethylhistidine	101-110	prolactin	Rattus norvegicus	146-155
3604804-1	1987	We investigated whether inhibition of brain histamine (HA) synthesis by alpha-fluoromethylhistidine (alpha-FMH) can influence basal or stimulated prolactin (PRL) release in male rats.	alpha-fluoromethylhistidine	101-110	prolactin	Rattus norvegicus	157-160
3604804-6	1987	administration of alpha-FMH significantly inhibited basal PRL secretion at 120 and 180 min.	alpha-fluoromethylhistidine	18-27	prolactin	Rattus norvegicus	58-61
4052095-0	1985	In vivo and in vitro inhibition of human histidine decarboxylase by (S)-alpha-fluoromethylhistidine.	alpha-fluoromethylhistidine	68-99	histidine decarboxylase	Homo sapiens	41-64
2948614-3	1986	Footshock significantly enhanced the HA depletion induced by alpha-fluoromethylhistidine, a specific inhibitor of histidine decarboxylase.	alpha-fluoromethylhistidine	61-88	histidine decarboxylase	Mus musculus	114-137
3761755-4	1986	Muscimol and AOAA also inhibited decrease in the histamine (HA) level induced by alpha-fluoromethylhistidine (50 mg/kg), a specific inhibitor of histidine decarboxylase.	alpha-fluoromethylhistidine	81-108	histidine decarboxylase	Mus musculus	145-168
2420333-12	1986	Both release of endogenous histamine and formation of radiolabeled histamine from labeled histidine were inhibited by the histidine decarboxylase inhibitor alpha-fluoromethylhistidine (10 microM).	alpha-fluoromethylhistidine	156-183	histidine decarboxylase	Rattus norvegicus	122-145
3713874-3	1986	In mice pretreated with alpha-fluoromethylhistidine, an inhibitor of histidine decarboxylase, PCP produced a marked hyperthermia.	alpha-fluoromethylhistidine	24-51	histidine decarboxylase	Mus musculus	69-92
4052095-2	1985	HDC activity was inhibited in vitro to more than 90% by (S)-alpha-fluoromethylhistidine (alpha-FMH) at concentrations of 10(-5) M and above.	alpha-fluoromethylhistidine	56-87	histidine decarboxylase	Homo sapiens	0-3
4052095-2	1985	HDC activity was inhibited in vitro to more than 90% by (S)-alpha-fluoromethylhistidine (alpha-FMH) at concentrations of 10(-5) M and above.	alpha-fluoromethylhistidine	89-98	histidine decarboxylase	Homo sapiens	0-3
4052095-5	1985	A dose-dependent inhibition of HDC activity was observed in PBL that were isolated both at 12 hr after administration of the first dose of alpha-FMH and after treatment for 1 week.	alpha-fluoromethylhistidine	139-148	histidine decarboxylase	Homo sapiens	31-34
4052095-6	1985	At the 50 and 100 mg doses of alpha-FMH, there was complete inhibition of HDC activity and partial inhibition at the 10 mg dose.	alpha-fluoromethylhistidine	30-39	histidine decarboxylase	Homo sapiens	74-77
4052095-7	1985	Twenty-four hours after the last dose, HDC activity had recovered to 64-100%, 44-46%, and 30-52% of control values in subjects that received 10, 50 and 100 mg alpha-FMH respectively.	alpha-fluoromethylhistidine	159-168	histidine decarboxylase	Homo sapiens	39-42
3841376-0	1985	Effects of alpha-fluoromethylhistidine on increase in histidine decarboxylase activity of maternal mouse kidney observed during late pregnancy and evidence for its non-mast cell origin by using estrogen and W/WV mice.	alpha-fluoromethylhistidine	11-38	histidine decarboxylase	Mus musculus	54-77
3841376-2	1985	administration of 25 mg/kg of alpha-fluoromethylhistidine (alpha-FMH), a suicide inhibitor of HDC, starting on day 13 of pregnancy.	alpha-fluoromethylhistidine	30-57	histidine decarboxylase	Mus musculus	94-97
3841376-2	1985	administration of 25 mg/kg of alpha-fluoromethylhistidine (alpha-FMH), a suicide inhibitor of HDC, starting on day 13 of pregnancy.	alpha-fluoromethylhistidine	59-68	histidine decarboxylase	Mus musculus	94-97
4058657-7	1985	Alpha-fluoromethylhistidine inhibited histidine decarboxylase activity almost totally in vitro at 10 microM and about 80% in vivo after six days of infusion (100 mg/kg/day) in all brain regions except the cerebellum.	alpha-fluoromethylhistidine	0-27	histidine decarboxylase	Rattus norvegicus	38-61
6491668-2	1984	The size of the neuronal HA pool was determined from the decrease in HA content, as induced by (S)-alpha-fluoro-methylhistidine (alpha-FMH), a suicide inhibitor of histidine decarboxylase.	alpha-fluoromethylhistidine	95-127	histidine decarboxylase	Cavia porcellus	164-187
4050131-8	1985	Pretreatment with alpha-fluoromethylhistidine (alpha FMH), a potent and specific inhibitor of histidine decarboxylase, produced a reduction in the effects of histidine.	alpha-fluoromethylhistidine	18-45	histidine decarboxylase	Rattus norvegicus	94-117
4050131-8	1985	Pretreatment with alpha-fluoromethylhistidine (alpha FMH), a potent and specific inhibitor of histidine decarboxylase, produced a reduction in the effects of histidine.	alpha-fluoromethylhistidine	47-56	histidine decarboxylase	Rattus norvegicus	94-117
3994743-1	1985	An irreversible inhibitor of histidine decarboxylase, alpha-fluoromethylhistidine (FMH), was used to inhibit histamine formation by mast cells in vivo.	alpha-fluoromethylhistidine	54-81	histidine decarboxylase	Homo sapiens	29-52
3994743-1	1985	An irreversible inhibitor of histidine decarboxylase, alpha-fluoromethylhistidine (FMH), was used to inhibit histamine formation by mast cells in vivo.	alpha-fluoromethylhistidine	83-86	histidine decarboxylase	Homo sapiens	29-52
4011742-1	1985	Effects of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase, on the sleep-waking parameters were studied in rats for 24 hours.	alpha-fluoromethylhistidine	40-43	histidine decarboxylase	Rattus norvegicus	75-98
6491668-2	1984	The size of the neuronal HA pool was determined from the decrease in HA content, as induced by (S)-alpha-fluoro-methylhistidine (alpha-FMH), a suicide inhibitor of histidine decarboxylase.	alpha-fluoromethylhistidine	129-138	histidine decarboxylase	Cavia porcellus	164-187
6208052-2	1984	Histamine catabolism inhibitors do not reproduce this effect; cells pre-incubated with alpha-fluoromethylhistidine are unresponsive to compound 48/80 which therefore activates pre-formed histidine decarboxylase rather than "inducing" it.	alpha-fluoromethylhistidine	87-114	histidine decarboxylase	Rattus norvegicus	187-210
6641910-1	1983	In rats, chronic infusion of alpha-fluoromethyl histidine, a selective irreversible inhibitor of mammalian histidine decarboxylase, caused a marked depletion of histamine in all tissues examined.	alpha-fluoromethylhistidine	29-57	histidine decarboxylase	Homo sapiens	107-130
6472496-7	1984	This assay was used to determine the in vivo changes in mouse brain histidine decarboxylase activity following irreversible inhibition with (+) alpha-fluoromethylhistidine (alpha-FMH).	alpha-fluoromethylhistidine	140-171	histidine decarboxylase	Mus musculus	68-91
6472496-7	1984	This assay was used to determine the in vivo changes in mouse brain histidine decarboxylase activity following irreversible inhibition with (+) alpha-fluoromethylhistidine (alpha-FMH).	alpha-fluoromethylhistidine	173-182	histidine decarboxylase	Mus musculus	68-91
6712729-0	1984	Mechanism of inactivation of mammalian L-histidine decarboxylase by (S)-alpha-fluoromethylhistidine.	alpha-fluoromethylhistidine	68-99	histidine decarboxylase	Homo sapiens	39-64
6712729-1	1984	The mechanism of inactivation by (S)-alpha-fluoromethylhistidine (FMH) of L-histidine decarboxylase (HDC, L-histidine carboxy-lyase, EC 4.1.1.22) purified from whole bodies of fetal rats was studied.	alpha-fluoromethylhistidine	33-64	histidine decarboxylase	Rattus norvegicus	74-99
6712729-1	1984	The mechanism of inactivation by (S)-alpha-fluoromethylhistidine (FMH) of L-histidine decarboxylase (HDC, L-histidine carboxy-lyase, EC 4.1.1.22) purified from whole bodies of fetal rats was studied.	alpha-fluoromethylhistidine	33-64	histidine decarboxylase	Rattus norvegicus	101-104
6712729-1	1984	The mechanism of inactivation by (S)-alpha-fluoromethylhistidine (FMH) of L-histidine decarboxylase (HDC, L-histidine carboxy-lyase, EC 4.1.1.22) purified from whole bodies of fetal rats was studied.	alpha-fluoromethylhistidine	66-69	histidine decarboxylase	Rattus norvegicus	74-99
6712729-1	1984	The mechanism of inactivation by (S)-alpha-fluoromethylhistidine (FMH) of L-histidine decarboxylase (HDC, L-histidine carboxy-lyase, EC 4.1.1.22) purified from whole bodies of fetal rats was studied.	alpha-fluoromethylhistidine	66-69	histidine decarboxylase	Rattus norvegicus	101-104
6693900-6	1984	Since neuronal histamine levels are maintained only by continued histidine decarboxylase activity, complete inhibition of this enzyme by alpha-fluoromethylhistidine, a "suicide" inhibitor of histidine decarboxylase, would totally deplete W/Wv mice of brain histamine.	alpha-fluoromethylhistidine	137-164	histidine decarboxylase	Mus musculus	65-88
6693900-6	1984	Since neuronal histamine levels are maintained only by continued histidine decarboxylase activity, complete inhibition of this enzyme by alpha-fluoromethylhistidine, a "suicide" inhibitor of histidine decarboxylase, would totally deplete W/Wv mice of brain histamine.	alpha-fluoromethylhistidine	137-164	histidine decarboxylase	Mus musculus	191-214
6864215-2	1983	The effects of alpha-fluoromethylhistidine (alpha-FMH) on the HDC activity and histamine content of the brain of W/Wv and +/+ mice were examined.	alpha-fluoromethylhistidine	44-53	histidine decarboxylase	Mus musculus	62-65
6864215-4	1983	injection of alpha-FMH the HDC activity of the brain had decreased to 10% of that in untreated mice.	alpha-fluoromethylhistidine	13-22	histidine decarboxylase	Mus musculus	27-30
6855476-0	1983	Effects of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase, on development of brain histamine and catecholamine systems in the neonatal rat.	alpha-fluoromethylhistidine	11-38	histidine decarboxylase	Rattus norvegicus	75-98
6855476-0	1983	Effects of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase, on development of brain histamine and catecholamine systems in the neonatal rat.	alpha-fluoromethylhistidine	40-43	histidine decarboxylase	Rattus norvegicus	75-98
6855476-1	1983	Daily administration of FMH to neonatal rats produced long-lasting inhibition of histidine decarboxylase in hypothalamus and cerebral cortex and led to depletion of histamine in both brain regions.	alpha-fluoromethylhistidine	24-27	histidine decarboxylase	Rattus norvegicus	81-104
6135617-3	1983	alpha-Fluoromethyl histidine inhibited the increase of histidine decarboxylase activity in the gastric mucosa, inhibited the rise of hypothalamic histamine content and decreased the incidence of gastric lesions to the same extent as did cimetidine.	alpha-fluoromethylhistidine	0-28	histidine decarboxylase	Rattus norvegicus	55-78
6860344-2	1983	alpha-Fluoromethyl histidine is an irreversible inhibitor of histidine decarboxylase.	alpha-fluoromethylhistidine	0-28	histidine decarboxylase	Rattus norvegicus	61-84
7160183-0	1982	Effect of alpha-monofluoromethyl histidine, an irreversible inhibitor of histidine decarboxylase, on gestation in mice.	alpha-fluoromethylhistidine	10-42	histidine decarboxylase	Mus musculus	73-96
6645794-0	1983	Developmental effects of alpha-fluoromethylhistidine, an irreversible inhibitor of histidine decarboxylase, on growth and on levels and turnover of catecholamines.	alpha-fluoromethylhistidine	25-52	histidine decarboxylase	Rattus norvegicus	83-106
6645794-1	1983	To examine the potential participation of histamine in cellular development, neonatal rats were given daily 50 mg/kg doses of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase; previous studies have shown this regimen to deplete both neurotransmitter and nonneurotransmitter pools of histamine.	alpha-fluoromethylhistidine	126-153	histidine decarboxylase	Rattus norvegicus	190-213
6645794-1	1983	To examine the potential participation of histamine in cellular development, neonatal rats were given daily 50 mg/kg doses of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase; previous studies have shown this regimen to deplete both neurotransmitter and nonneurotransmitter pools of histamine.	alpha-fluoromethylhistidine	155-158	histidine decarboxylase	Rattus norvegicus	190-213
6830620-1	1983	Effect of inhibition of histidine decarboxylase by alpha-fluoromethylhistidine.	alpha-fluoromethylhistidine	51-78	histidine decarboxylase	Rattus norvegicus	24-47
6830620-2	1983	Preincubation with (S)-alpha-fluoromethylhistidine, an irreversible inhibitor of histidine decarboxylase, was found to markedly reduce, but not eliminate, the uptake of [3H]histidine by rat peritoneal mast cells.	alpha-fluoromethylhistidine	19-50	histidine decarboxylase	Rattus norvegicus	81-104
7160183-1	1982	Chronic administration of alpha-monofluoromethyl histidine, a specific inhibitor of histidine decarboxylase, to pregnant mice blocked histidine decarboxylase activity and markedly depleted histamine levels in 18-day-old foetuses and in newborn mice.	alpha-fluoromethylhistidine	26-58	histidine decarboxylase	Mus musculus	84-107
7160183-1	1982	Chronic administration of alpha-monofluoromethyl histidine, a specific inhibitor of histidine decarboxylase, to pregnant mice blocked histidine decarboxylase activity and markedly depleted histamine levels in 18-day-old foetuses and in newborn mice.	alpha-fluoromethylhistidine	26-58	histidine decarboxylase	Mus musculus	134-157
7452304-1	1980	alpha-Fluoromethylhistidine (alpha-FMH), a new potent inhibitor of histidine decarboxylase (HD), has been used for in vitro and in vivo studies of brain HD.	alpha-fluoromethylhistidine	0-27	histidine decarboxylase	Mus musculus	67-90
7126249-0	1982	Effect of alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase, on histamine levels in mouse tissues.	alpha-fluoromethylhistidine	10-37	histidine decarboxylase	Mus musculus	62-85
7452304-1	1980	alpha-Fluoromethylhistidine (alpha-FMH), a new potent inhibitor of histidine decarboxylase (HD), has been used for in vitro and in vivo studies of brain HD.	alpha-fluoromethylhistidine	29-38	histidine decarboxylase	Mus musculus	67-90
33030036-10	2020	In the thrombin generation assay, FMH and UFH produced comparable inhibition of thrombin generation as measured by various parameters.	alpha-fluoromethylhistidine	34-37	coagulation factor II, thrombin	Homo sapiens	80-88
33390452-6	2021	alpha-Fluoromethylhistidine, an histidine decarboxylase inhibitor, also inhibited active avoidance response.	alpha-fluoromethylhistidine	0-27	histidine decarboxylase	Rattus norvegicus	32-55
27342775-6	2016	Histidine decarboxylase (HDC) enzyme inhibitor alpha-fluoromethylhistidine was administered intracerebroventricularly (i.c.v.).	alpha-fluoromethylhistidine	47-74	histidine decarboxylase	Rattus norvegicus	0-23
28228363-3	2017	(S)-alpha-Fluoromethylhistidine di-hydrochloride (alpha-FMH) is a potent HDC inhibitor that is commercially available at high cost in small amounts only.	alpha-fluoromethylhistidine	50-59	histidine decarboxylase	Homo sapiens	73-76
28228363-7	2017	In view of this predictive data, the efficacy of alpha-FMH as a GST inhibitor was investigated in vitro.	alpha-fluoromethylhistidine	49-58	glutathione S-transferase kappa 1	Homo sapiens	64-67
28228363-8	2017	alpha-FMH was demonstrated to be an effective inhibitor of GST at micromolar concentration, suggesting that off-target effects of alpha-FMH may limit physiological drug metabolism and elimination by GST-dependent mechanisms.	alpha-fluoromethylhistidine	0-9	glutathione S-transferase kappa 1	Homo sapiens	59-62
28228363-8	2017	alpha-FMH was demonstrated to be an effective inhibitor of GST at micromolar concentration, suggesting that off-target effects of alpha-FMH may limit physiological drug metabolism and elimination by GST-dependent mechanisms.	alpha-fluoromethylhistidine	0-9	glutathione S-transferase kappa 1	Homo sapiens	199-202
28228363-8	2017	alpha-FMH was demonstrated to be an effective inhibitor of GST at micromolar concentration, suggesting that off-target effects of alpha-FMH may limit physiological drug metabolism and elimination by GST-dependent mechanisms.	alpha-fluoromethylhistidine	130-139	glutathione S-transferase kappa 1	Homo sapiens	59-62
28228363-8	2017	alpha-FMH was demonstrated to be an effective inhibitor of GST at micromolar concentration, suggesting that off-target effects of alpha-FMH may limit physiological drug metabolism and elimination by GST-dependent mechanisms.	alpha-fluoromethylhistidine	130-139	glutathione S-transferase kappa 1	Homo sapiens	199-202
27833003-2	2017	We analysed the effect of acute histamine depletion by means of i. c.v. injections of alpha-fluoromethylhistidine, a blocker of histidine decarboxylase, on the temporal organization of motor sequences of CD1 mice behaviour in the open-field test.	alpha-fluoromethylhistidine	86-113	histidine decarboxylase	Mus musculus	128-151
27833003-2	2017	We analysed the effect of acute histamine depletion by means of i. c.v. injections of alpha-fluoromethylhistidine, a blocker of histidine decarboxylase, on the temporal organization of motor sequences of CD1 mice behaviour in the open-field test.	alpha-fluoromethylhistidine	86-113	CD1 antigen complex	Mus musculus	204-207
27342775-6	2016	Histidine decarboxylase (HDC) enzyme inhibitor alpha-fluoromethylhistidine was administered intracerebroventricularly (i.c.v.).	alpha-fluoromethylhistidine	47-74	histidine decarboxylase	Rattus norvegicus	25-28
25562630-5	2015	The protective effect of carnosine or histidine was completely abolished by alpha-fluoromethylhistidine (alpha-FMH), a selective and irreversible histidine decarboxylase inhibitor, or in histidine decarboxylase deficient (HDC-KO) mice.	alpha-fluoromethylhistidine	76-103	histidine decarboxylase	Mus musculus	146-169
25562630-5	2015	The protective effect of carnosine or histidine was completely abolished by alpha-fluoromethylhistidine (alpha-FMH), a selective and irreversible histidine decarboxylase inhibitor, or in histidine decarboxylase deficient (HDC-KO) mice.	alpha-fluoromethylhistidine	105-114	histidine decarboxylase	Mus musculus	146-169
22223343-7	2012	Mice given a histamine H1-receptor antagonist [fexofenadine (peripherally acting) or pyrilamine (peripherally and centrally acting)] or an irreversible HDC inhibitor (alpha-fluoromethylhistidine) displayed less PW endurance than control mice.	alpha-fluoromethylhistidine	167-194	histidine decarboxylase	Mus musculus	152-155
23773488-5	2013	In addition, a depletion of endogenous histamine with alpha-fluoromethylhistidine (alpha-FMH), a specific HDC inhibitor, or feeding mice a low-histamine diet also enhanced nociception in the wild-types.	alpha-fluoromethylhistidine	54-81	histidine decarboxylase	Mus musculus	106-109
23773488-5	2013	In addition, a depletion of endogenous histamine with alpha-fluoromethylhistidine (alpha-FMH), a specific HDC inhibitor, or feeding mice a low-histamine diet also enhanced nociception in the wild-types.	alpha-fluoromethylhistidine	83-92	histidine decarboxylase	Mus musculus	106-109
23773488-6	2013	Nav 1.8 expression in primary afferent neurons was increased both in HDC(-/-) and in alpha-FMH-treated wild-type mice.	alpha-fluoromethylhistidine	85-94	sodium channel, voltage-gated, type X, alpha	Mus musculus	0-7
23432085-7	2013	BDNF-induced feeding suppression was partially attenuated in rats pre-treated with FMH or a CRF antagonist, and in H1KO mice.	alpha-fluoromethylhistidine	83-86	brain-derived neurotrophic factor	Rattus norvegicus	0-4
23127196-9	2012	alpha-Fluoromethylhistidine (100 mumol/L), a selective and irreversible inhibitor of histidine decarboxylase, also significantly inhibited the protective effects of carnosine.	alpha-fluoromethylhistidine	0-27	histidine decarboxylase	Mus musculus	85-108
20588322-6	2011	Vascular endothelial growth factor (VEGF) mRNA and protein expressions showed a greater increase after hypoxia than those in HDC-KO or alpha-FMH-treated WT mice.	alpha-fluoromethylhistidine	135-144	vascular endothelial growth factor A	Mus musculus	0-34