PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 35103034-9 2022 The lead antiviral compounds sespenine, xiamycin C, xiamycin methyl ester, and xiamycin A are recommended as the most promising inhibitors against nsp10 of SARS-CoV-2 pathogenicity. xiamycin 79-89 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 147-152 28643772-4 2017 Here we report the in vitro reconstitution of an unusual flavin-dependent bacterial indoloterpenoid cyclase, XiaF, together with a designated flavoenzyme-reductase (XiaP) that mediates a key step in xiamycin biosynthesis. xiamycin 199-207 X-linked inhibitor of apoptosis Homo sapiens 165-169 34829734-7 2021 Similarly, marine terpenoids such as xiamycin (-9.3), thyrsiferol (-9.2), liouvilloside B (-8.9), liouvilloside A (-8.8), and stachyflin (-8.7) exhibited comparatively higher docking scores than the referral drug remdesivir (-7.4), and favipiravir (-5.7) against the target SARS-CoV-2-RdRp. xiamycin 37-45 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 285-289 34604898-0 2021 Enantioselective first total syntheses of the antiviral natural products xiamycins D and E. The enantioselective first total syntheses of marine pentacyclic indolosesquiterpenoids xiamycins D (4) and E (5) have been described for the first time to the best of our knowledge. xiamycin 73-82 Rho guanine nucleotide exchange factor 15 Homo sapiens 180-205