PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
12015081-1	2002	OBJECTIVE: To investigate the in vitro killing efficiency of D-amino acid oxidase (DAAO)/D-alanine (D-Ala) system on K562e cells.	dalbergioidin	100-105	D-amino acid oxidase	Homo sapiens	61-81
12204559-4	2002	A defined alr deletion mutant of C. glutamicum displayed a strict dependence on the presence of D-alanine for growth on complex and minimal medium.	dalbergioidin	96-105	alanine racemase	Corynebacterium glutamicum ATCC 13032	10-13
12204559-6	2002	In vivo complementation of the chromosomal alr deletion with alr-carrying vectors permitted growth of the mutant strain in the absence of external D-alanine and provided strong selective pressure to maintain the plasmid.	dalbergioidin	147-156	alanine racemase	Corynebacterium glutamicum ATCC 13032	43-46
12204559-6	2002	In vivo complementation of the chromosomal alr deletion with alr-carrying vectors permitted growth of the mutant strain in the absence of external D-alanine and provided strong selective pressure to maintain the plasmid.	dalbergioidin	147-156	alanine racemase	Corynebacterium glutamicum ATCC 13032	61-64
11952892-7	2002	Two of the characterized mutants are affected in the major autolysin (atlE) and in D-alanine esterification of teichoic acids (dltA).	dalbergioidin	83-92	dihydrolipoamide S-acetyltransferase	Homo sapiens	127-131
11849532-1	2002	The dlt operon of Gram-positive bacteria comprises four genes (dltA, dltB, dltC and dltD) that catalyse the incorporation of D-alanine residues into the cell wall-associated lipoteichoic acids (LTAs).	dalbergioidin	125-134	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	63-67
12015081-1	2002	OBJECTIVE: To investigate the in vitro killing efficiency of D-amino acid oxidase (DAAO)/D-alanine (D-Ala) system on K562e cells.	dalbergioidin	100-105	D-amino acid oxidase	Homo sapiens	83-87
12015081-4	2002	The killing activities of D-Ala to DAAO(+) cells alone or the mixtures of DAAO(+) and DAAO(-) cells in different ratios were observed.	dalbergioidin	26-31	D-amino acid oxidase	Homo sapiens	35-39
12015081-10	2002	CONCLUSION: The leukemia cell line K562e was sensitive to DAAO/D-Ala system and there was no significant bystander effects observed within this cells.	dalbergioidin	63-68	D-amino acid oxidase	Homo sapiens	58-62
11244061-5	2001	S. pombe uses D-alanine as a sole nitrogen source, but deletion of the alr1(+) gene resulted in retarded growth on the same medium.	dalbergioidin	14-23	Mg(2+) transporter ALR1	Saccharomyces cerevisiae S288C	71-75
16200714-1	2001	OBJECTIVE: To explore the feasibility of expression of R. gracilis D-amino acid oxidase(DAAO) gene in leukemia cell line K562 and the cytotoxicity of D-Alanine to the cells.	dalbergioidin	150-159	D-amino acid oxidase	Homo sapiens	88-92
11244061-9	2001	However, heterologous expression of the alr1(+) gene enabled S. cerevisiae to grow efficiently on D-alanine as a sole nitrogen source.	dalbergioidin	98-107	Mg(2+) transporter ALR1	Saccharomyces cerevisiae S288C	40-44
9756984-0	1998	Sequence of the putative alanine racemase operon in Staphylococcus aureus: insertional interruption of this operon reduces D-alanine substitution of lipoteichoic acid and autolysis.	dalbergioidin	123-132	AT695_RS06560	Staphylococcus aureus	25-41
10906151-1	2000	The present study examined whether metabolism of the putative angiotensin-(1-7) receptor agonist and antagonist [angiotensin-(1-7) and D-alanine(7) angiotensin-(1-7), respectively] altered their ability to interact with angiotensin AT(1), AT(2), and AT(4) receptor subtypes.	dalbergioidin	135-144	MAS1 proto-oncogene, G protein-coupled receptor	Rattus norvegicus	62-88
10906151-2	2000	Both angiotensin-(1-7) and D-alanine(7) angiotensin-(1-7) competed with low affinity for (125)I-sarcosine(1), isoleucine(8) angiotensin II binding to AT(1) and AT(2) receptors in rat liver and adrenal medulla membranes, respectively, and competed with low affinity for (125)I-angiotensin IV binding to AT(4) receptors in bovine kidney epithelial cell membranes.	dalbergioidin	27-36	angiotensinogen	Rattus norvegicus	124-138
10741686-2	2000	The DAAO activity in the liver with D-alanine and D-serine decreased by 33-62% in the diabetic group while the decrease in the kidneys was 61-74%.	dalbergioidin	36-45	D-amino-acid oxidase	Rattus norvegicus	4-8
10206711-8	1999	Analysis of degradation products of cell wall devoid of teichoic-acid-bound O-esterified D-alanine unambiguously confirmed that LytF cuts the gamma-D-glutamate-mesodiaminopimelate bond.	dalbergioidin	89-98	gamma-D-glutamate-meso-diaminopimelate muropeptidase (major autolysin, vegetative)	Bacillus subtilis subsp. subtilis str. 168	128-132
10978770-3	2000	The highest D-amino acid oxidase (DAAO) activity was 705 U (mg of protein)(-)(1), which was about 12-fold higher than that of D-alanine-induced T. variabilis.	dalbergioidin	126-135	D-amino acid oxidase	Sus scrofa	34-38
8863813-3	1996	Mutations at NR1(D732) also changed sensitivity to the glycine-site agonists D-serine and D-alanine, reducing the potencies and, in some cases, the efficacies of these compounds.	dalbergioidin	90-99	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	13-16
9644264-3	1998	The 1,605-cm-1 Raman band of the anionic reduced flavin in the purple intermediate of D-amino acid oxidase (DAO) with D-proline or D-alanine does not shift in DAO reconstituted with [4-carbonyl-18O]FAD, although it shifts with [4,10a-13C2]- or [4a-13C]FAD.	dalbergioidin	131-140	D-amino acid oxidase	Homo sapiens	86-106
9644264-3	1998	The 1,605-cm-1 Raman band of the anionic reduced flavin in the purple intermediate of D-amino acid oxidase (DAO) with D-proline or D-alanine does not shift in DAO reconstituted with [4-carbonyl-18O]FAD, although it shifts with [4,10a-13C2]- or [4a-13C]FAD.	dalbergioidin	131-140	D-amino acid oxidase	Homo sapiens	108-111
9472778-9	1998	These results demonstrate that expression of R. gracilis DAAO in tumor cells confers chemosensitivity to D-alanine that could be exploited as a novel cancer gene therapy paradigm.	dalbergioidin	105-114	D-amino acid oxidase	Homo sapiens	57-61
8940030-4	1996	Further analysis for PLP-dependent reactions showed that this antibody catalyzes the cofactor-dependent transamination of hydrophobic D-amino acids and oxo acids (kcat" = 0.42 min-1 with D-alanine).	dalbergioidin	187-196	pyridoxal phosphatase	Homo sapiens	21-24
8940030-7	1996	The antibody further accelerates the reaction (kcat(antibody)"/kcat(PLP)" = 5 x 10(3) with D-alanine as substrate) and ensures reaction specificity, stereospecificity, as well as limited substrate specificity.	dalbergioidin	91-100	pyridoxal phosphatase	Homo sapiens	68-71
9485439-6	1998	Using a high-performance liquid chromatography-based method for the determination of pyridoxo cofactors, we detected a new intermediate closely related to the inactivation by d-alanine; its formation occurred at the same rate as the inactivation and upon reactivation it reverted to PLP.	dalbergioidin	175-184	pyridoxal phosphatase	Homo sapiens	283-286
8916922-14	1996	The active site structure appears to be very similar to the ones previously determined for D-alanine:D-alanine ligase and biotin carboxylase.	dalbergioidin	91-100	methylcrotonyl-CoA carboxylase subunit 2	Homo sapiens	122-140
7916120-0	1994	Amino acid levels in D-alanine-administered mutant mice lacking D-amino acid oxidase.	dalbergioidin	21-30	D-amino acid oxidase	Mus musculus	64-84
7916120-1	1994	D-Alanine was administered orally to mutant mice lacking D-amino acid oxidase (EC 1.4.3.3).	dalbergioidin	0-9	D-amino acid oxidase	Mus musculus	57-77
7908225-3	1994	Conditions have previously been established under which large, limiting, primary deuterium kinetic isotope effects can be measured with D-alanine, D-serine, and glycine as substrates for D-amino acid oxidase [Denu, J. M., & Fitzpatrick, P. F. (1992) Biochemistry 31, 8207-8215].	dalbergioidin	136-145	D-amino acid oxidase	Homo sapiens	187-207
7910822-4	1994	The effects of pH and D2O on the kinetics of the oxidative half-reaction of D-amino-acid oxidase have been determined with glycine, D-alanine, and D-serine as substrates.	dalbergioidin	132-141	D-amino acid oxidase	Homo sapiens	76-96
7901999-1	1993	Urine of mutant ddY/DAO- mice lacking D-amino-acid oxidase contained 13 times more D-alanine than that of normal ddY/DAO+ mice.	dalbergioidin	83-92	D-amino acid oxidase	Mus musculus	20-23
8125347-0	1994	Sequence of the vanB and ddl genes encoding D-alanine:D-lactate and D-alanine:D-alanine ligases in vancomycin-resistant Enterococcus faecalis V583.	dalbergioidin	44-53	D-alanine--(R)-lactate ligase VanB	Enterococcus faecalis V583	16-20
8125347-0	1994	Sequence of the vanB and ddl genes encoding D-alanine:D-lactate and D-alanine:D-alanine ligases in vancomycin-resistant Enterococcus faecalis V583.	dalbergioidin	68-77	D-alanine--(R)-lactate ligase VanB	Enterococcus faecalis V583	16-20
7901999-3	1993	In ddY/DAO- mice that were made germ free at birth and reared in a germ-free environment, the quantity of urinary D-alanine was found to be at a low level comparable to that of the normal mice.	dalbergioidin	114-123	D-amino acid oxidase	Mus musculus	7-10
7901999-6	1993	These results indicate that most of the urinary D-alanine of the conventionally reared ddY/DAO- mice is of gastrointestinal bacterial origin.	dalbergioidin	48-57	D-amino acid oxidase	Mus musculus	91-94
8340416-6	1993	When cells expressing [Ala93]- or [Ser93]progastrin were incubated in the presence of 1 mg/ml D-alanine or D-serine, respectively, a small but consistent amount of amidated gastrin production was detected (< 1% of wild type).	dalbergioidin	94-103	gastrin	Rattus norvegicus	44-51
1510448-3	1992	VanY was associated with the cell membranes and cleaved the C-terminal D-alanine residue of UDP-muramyl-pentapeptide but did not display transpeptidase or beta-lactamase activities.	dalbergioidin	71-80	VanY protein	Enterococcus faecium	0-4
1526036-0	1992	Effect of quality of D-alanine in specimen blank reagents for measurements of alanine aminotransferase by IFCC recommended method.	dalbergioidin	21-30	glutamic--pyruvic transaminase	Homo sapiens	78-102
1478265-6	1992	In the CA1 region and the dentate gyrus, D- and L-serine and D-alanine (10(-3) M) also showed the LTP-facilitating effects in a similar manner to glycine, but D- and L-valine had no effect on LTP generation.	dalbergioidin	61-70	carbonic anhydrase 1	Rattus norvegicus	7-10
1522072-1	1992	Vancomycin resistance plasmids in enterococci carry the genes vanH and vanA, which encode enzymes catalyzing, respectively, the reduction of 2-keto acids to 2-D-hydroxy acids and the addition of D-hydroxy acids to D-alanine.	dalbergioidin	214-223	VanA	Enterococcus faecalis	71-75
1931965-4	1991	VanA was found to catalyze ester bond formation between D-alanine and the D-hydroxy acid products of VanH, the best substrate being D-2-hydroxybutyrate (Km = 0.60 mM).	dalbergioidin	56-65	Vancomycin Teicoplanin A-type resistance protein VanA / D-alanine--D-alanine ligase	Enterococcus faecium	0-4
1503450-1	1992	The VanA ligase encoded by the vancomycin resistance plasmid pIP816 of Enterococcus faecium BM4147 condenses D-alanine with various D-2-hydroxy and D-2-amino acids in vitro.	dalbergioidin	109-118	Vancomycin Teicoplanin A-type resistance protein VanA / D-alanine--D-alanine ligase	Enterococcus faecium	4-8
1931965-4	1991	VanA was found to catalyze ester bond formation between D-alanine and the D-hydroxy acid products of VanH, the best substrate being D-2-hydroxybutyrate (Km = 0.60 mM).	dalbergioidin	56-65	VanH protein	Enterococcus faecium	101-105
2145213-2	1990	The concentration of NEP was quantified in detergent extracts of synovial tissues by the percentage hydrolysis of [3H-D-Ala]-Leu enkephalin/hr/100 mg of tissue.	dalbergioidin	115-123	membrane metalloendopeptidase	Homo sapiens	21-24
1973033-0	1990	Intestinal bacterial origin of D-alanine in urine of mutant mice lacking D-amino-acid oxidase.	dalbergioidin	31-40	D-amino acid oxidase	Mus musculus	73-93
1973033-1	1990	Urine from mutant mice which lack D-amino-acid oxidase contained a large amount of D-alanine.	dalbergioidin	83-92	D-amino acid oxidase	Mus musculus	34-54
34415013-7	2021	Aal and acp genes were associated with dltBD-like homologs that modify cell wall teichoic acids with D-alanine, including in Paenibacillus and certain other bacteria.	dalbergioidin	101-110	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	8-11
34783546-3	2021	Here, we have engineered a d-alanine-specific SBP into a fluorescence biosensor with specificity for the signaling molecule d-serine (D-serFS).	dalbergioidin	27-36	spermine binding protein	Rattus norvegicus	46-49
35089810-3	2022	When DAAO-infected animals are fed the DAAO substrate D-alanine, the enzyme generates hydrogen peroxide (H2O2) in the cardiac myocytes, leading to dilated cardiomyopathy.	dalbergioidin	54-63	D-amino-acid oxidase	Rattus norvegicus	5-9
35089810-3	2022	When DAAO-infected animals are fed the DAAO substrate D-alanine, the enzyme generates hydrogen peroxide (H2O2) in the cardiac myocytes, leading to dilated cardiomyopathy.	dalbergioidin	54-63	D-amino-acid oxidase	Rattus norvegicus	39-43
35089810-6	2022	Rats infected with recombinant cardiotropic AAV9 expressing DAAO or control AAV9 were treated for 7 weeks with D-alanine to stimulate chemogenetic H2O2 production by DAAO and generate dilated cardiomyopathy.	dalbergioidin	111-120	D-amino-acid oxidase	Rattus norvegicus	60-64
35089810-6	2022	Rats infected with recombinant cardiotropic AAV9 expressing DAAO or control AAV9 were treated for 7 weeks with D-alanine to stimulate chemogenetic H2O2 production by DAAO and generate dilated cardiomyopathy.	dalbergioidin	111-120	D-amino-acid oxidase	Rattus norvegicus	166-170
35204316-7	2022	HUVEC stably overexpressing DAO (DAO-HUVEC) were exposed to D-alanine (3 mM), exogenous H2O2 (10 microM or 300 microM), or menadione (5 microM) for various timepoints and subjected to global untargeted metabolomics (LC-MS/MS) and RNAseq by MACE (Massive analysis of cDNA ends).	dalbergioidin	60-69	D-amino acid oxidase	Homo sapiens	28-31
2909518-8	1989	The RYD region of H-CDR3 appeared to be central to its function, because substitution of the tyrosine with glycine increased the inhibitory potency of the peptide by 10-fold, while replacing the tyrosine with D-alanine or inverting the RYD sequence sharply reduced the inhibitory potency.	dalbergioidin	209-218	CDR3	Homo sapiens	20-24
2570568-0	1989	Spontaneous excretion of D-alanine in urine in mutant mice lacking D-amino-acid oxidase.	dalbergioidin	25-34	D-amino acid oxidase	Mus musculus	67-87
3631267-7	1987	Interestingly, D-alanine was more effective than L-alanine in stimulating ODC activity in the jejunum.	dalbergioidin	15-24	ornithine decarboxylase 1	Rattus norvegicus	74-77
2943013-2	1986	LH-RH analogs, substituted in position 6 by D-tryptophane, D-serine(tBu), D-leucine or D-alanine induce a strong stimulation of the gonadotrophs, followed by a desensitization of the LH-RH receptors, which leads to a blockade of the gonadotropin secretion and to a hypogonadism.	dalbergioidin	87-96	gonadotropin releasing hormone 1	Homo sapiens	0-5
2879563-3	1986	6-Azido-FMN Old Yellow Enzyme is converted to the 6-amino-FMN enzyme by aerobic turnover with NADPH, and 6-azido-FAD D-amino acid oxidase is converted to the 6-amino-FAD enzyme by treatment with D-alanine.	dalbergioidin	195-204	formin 1	Homo sapiens	8-11
2879563-3	1986	6-Azido-FMN Old Yellow Enzyme is converted to the 6-amino-FMN enzyme by aerobic turnover with NADPH, and 6-azido-FAD D-amino acid oxidase is converted to the 6-amino-FAD enzyme by treatment with D-alanine.	dalbergioidin	195-204	formin 1	Homo sapiens	58-61
2874789-1	1986	In water, the purified 26 000-Mr membrane-bound DD-peptidase of Streptomyces K15 hydrolyses the ester carbonyl donor Ac2-L-Lys-D-Ala-D-lactate (release of D-lactate) and the amide carbonyl donor Ac2-L-Lys-D-Ala-D-Ala (release of D-alanine) with accumulation of acyl- (Ac2-L-Lys-D-alanyl-)enzyme.	dalbergioidin	229-238	adenylate cyclase 2	Homo sapiens	117-120
2874789-2	1986	Whereas hydrolysis of the ester substrate proceeds to completion, hydrolysis of the amide substrate is negligible because of the capacity of the K15 DD-peptidase for utilizing the released D-alanine in a transfer reaction (Ac2-L-Lys-D-Ala-D-Ala + D-Ala----Ac2-L-Lys-D-Ala-D-Ala + D-Ala) that maintains the concentration of the amide substrate at a constant level.	dalbergioidin	189-198	adenylate cyclase 2	Homo sapiens	223-226
2874789-2	1986	Whereas hydrolysis of the ester substrate proceeds to completion, hydrolysis of the amide substrate is negligible because of the capacity of the K15 DD-peptidase for utilizing the released D-alanine in a transfer reaction (Ac2-L-Lys-D-Ala-D-Ala + D-Ala----Ac2-L-Lys-D-Ala-D-Ala + D-Ala) that maintains the concentration of the amide substrate at a constant level.	dalbergioidin	189-198	adenylate cyclase 2	Homo sapiens	256-259
2874789-4	1986	Under proper conditions, the acceptor activity of water and, in the case of the amide substrate, the acceptor activity of the released D-alanine can be totally overcome so that the two substrates are quantitatively converted into transpeptidated product Ac2-L-Lys-D-Ala-NH-X (and hydrolysis is prevented).	dalbergioidin	135-144	adenylate cyclase 2	Homo sapiens	254-257
6362662-1	1983	Des-(B25-B30)-hexapeptide-insulin with B23-glycine replaced by D-alanine was prepared by a combination of enzymic and non-enzymic syntheses.	dalbergioidin	63-72	insulin	Sus scrofa	26-33
2985133-3	1985	We have examined binding of D-Ala6-des-Gly10-GnRH ethylamide (D-Ala) to rabbit corpora lutea, and have investigated the luteolytic activity of this analogue in hypophysectomized, pseudopregnant rabbits.	dalbergioidin	28-33	gonadotropin releasing hormone 1	Rattus norvegicus	45-49
6409810-1	1983	The influence of D-alanine and carbohydrate substitution of lipoteichoic acids (LTAs) on the binding of antibody directed to the polyglycerol phosphate (PGP) portion was found to be at least partially dependent upon the mode of presentation of the antigen.	dalbergioidin	17-26	phosphoglycolate phosphatase	Homo sapiens	153-156
7308349-3	1981	In so called "Tandem" experiments it was shown that D-Ala had opposite effects on the CA1 pyramidal and FD granule cells.	dalbergioidin	52-57	carbonic anhydrase 1	Homo sapiens	86-89
6860314-1	1983	The non-metabolizable amino acids alpha-aminoisobutyric acid (AIB) and cycloleucine and the poorly metabolizable amino acid D-alanine potently stimulated hepatic ornithine decarboxylase (ODC) activity in starved rats.	dalbergioidin	124-133	ornithine decarboxylase 1	Rattus norvegicus	162-185
7370278-5	1980	Thrombin and Factor Xa may possess a hydrophobic region near the P2 binding site which is unfavourable for either asparagine or D-alanine but which readily accommodates glycine, L-alanine or L-phenylalanine.	dalbergioidin	128-137	coagulation factor II, thrombin	Bos taurus	0-8
14091-3	1977	The presence of D-amino acid oxidase was determined using H2O2 generated by the enzyme, D-alanine as a substrate, and cerous ions for the formation of an electron-dense precipitate.	dalbergioidin	88-97	D-amino acid oxidase	Homo sapiens	16-36
562846-2	1977	Seven out of eighty-one recipients were found to have donor allotype clones, all of which produced IgG1 antibodies to D-ala; two of these clones also produced small quantities of IgG2a antibodies.	dalbergioidin	118-123	LOC105243590	Mus musculus	99-103
562846-3	1977	In addition, each of the seven responder mice contained IgM antibodies to D-ala.	dalbergioidin	74-79	immunoglobulin heavy constant mu	Mus musculus	56-59
224457-2	1979	The binding is inhibited by low concentrations of beta-endorphin and its D-alanine derivative, but is not affected by opiate agonists and antagonists, or by enkephalin analogs, beta-lipotropin, adrenocorticotrophic hormone, or alpha-melanocyte-stimulating hormone; this suggests the existence of a specific, non-opiate binding site (receptor) for beta-endorphin.	dalbergioidin	73-82	proopiomelanocortin	Homo sapiens	50-64
224457-2	1979	The binding is inhibited by low concentrations of beta-endorphin and its D-alanine derivative, but is not affected by opiate agonists and antagonists, or by enkephalin analogs, beta-lipotropin, adrenocorticotrophic hormone, or alpha-melanocyte-stimulating hormone; this suggests the existence of a specific, non-opiate binding site (receptor) for beta-endorphin.	dalbergioidin	73-82	proopiomelanocortin	Homo sapiens	227-263
224457-2	1979	The binding is inhibited by low concentrations of beta-endorphin and its D-alanine derivative, but is not affected by opiate agonists and antagonists, or by enkephalin analogs, beta-lipotropin, adrenocorticotrophic hormone, or alpha-melanocyte-stimulating hormone; this suggests the existence of a specific, non-opiate binding site (receptor) for beta-endorphin.	dalbergioidin	73-82	proopiomelanocortin	Homo sapiens	347-361
23164-2	1978	Progesterone inhibited D-amino acid oxidase (D-amino acid : O2 oxidoreductase (deaminating), EC 1.4.3.3) in competition with its substrate, D-alanine.	dalbergioidin	140-149	D-amino acid oxidase	Homo sapiens	23-43
32930873-10	2020	Specific immunolocalization of D-alanine in pituitary ACTH-secreting cells and pancreatic beta-cells suggests that this amino acid participates in blood glucose regulation in mammals.	dalbergioidin	31-40	proopiomelanocortin	Homo sapiens	54-58
190192-0	1976	[Synthesis of [D-alanine, 4"-azido-3",5"-ditritio-L-phenylalanine, norvaline4[alpha-melanotropin as a "photoaffinity probe" for hormone-receptor interactions (author"s transl)].	dalbergioidin	15-24	nuclear receptor subfamily 4 group A member 1	Homo sapiens	128-144
4199510-1	1973	Genetic analysis of a d-alanine requiring mutant (dal) of Bacillus subtilis reveals that the gene that codes for d,l-alanine racemase is linked to purB.	dalbergioidin	22-31	purine rich element binding protein B	Sus scrofa	147-151
4389707-2	1968	Injection of d-alanine or monocontamination with Bacillus cereus stimulated d-amino acid oxidase activity in the kidneys of germ-free mice.	dalbergioidin	13-22	D-amino acid oxidase	Mus musculus	76-96
32277698-5	2020	D-cycloserine (DCS) is a D-Alanine analogue that targets peptidoglycan biosynthesis by inhibiting D-Alanine:D-Alanine ligase (Ddl).	dalbergioidin	25-34	AT695_RS07115	Staphylococcus aureus	98-124
32522780-9	2020	In the presence of d-alanine, SEDeltaDeltaDelta colonized and increased expression of human beta-defensin 2 in cultured human skin models in vitro.	dalbergioidin	19-28	defensin beta 4B	Homo sapiens	92-107
32325540-5	2020	Following a bolus of hyperpolarized d-alanine, accumulation of pyruvate, lactate and bicarbonate was observed only when DAO activity was not inhibited.	dalbergioidin	36-45	D-amino-acid oxidase	Rattus norvegicus	120-123
32277698-5	2020	D-cycloserine (DCS) is a D-Alanine analogue that targets peptidoglycan biosynthesis by inhibiting D-Alanine:D-Alanine ligase (Ddl).	dalbergioidin	25-34	AT695_RS07115	Staphylococcus aureus	126-129
30554648-3	2019	d-amino acid oxidase (DAAO) catalyzes the oxidative deamination of d-amino acids (e.g. d-alanine), and H2O2 is evolved.	dalbergioidin	87-96	D-amino acid oxidase	Homo sapiens	0-20
31422081-9	2019	ADAS-cog behavior scores were negatively correlated with D-glutamate (r = -0.177, p = 0.034) and L-glutamate (r = -0.250, p = 0.003), but positively correlated with D-alanine (r = 0.236, p = 0.005) and D-/Total- alanine ratio (r = 0.252, p = 0.002).	dalbergioidin	165-174	alkylglycerone phosphate synthase	Homo sapiens	0-4
30447031-2	2019	d-Alanine can be deaminated back to pyruvate by d-amino acid oxidase (DAAOs).	dalbergioidin	0-9	D-amino acid oxidase	Homo sapiens	48-68
30447031-2	2019	d-Alanine can be deaminated back to pyruvate by d-amino acid oxidase (DAAOs).	dalbergioidin	0-9	D-amino acid oxidase	Homo sapiens	70-75
30447031-5	2019	Thus the transfer of pyruvate and d-alanine between RTA and DAAO can be directional and efficient.	dalbergioidin	34-43	MAS related GPR family member F	Homo sapiens	52-55
30447031-5	2019	Thus the transfer of pyruvate and d-alanine between RTA and DAAO can be directional and efficient.	dalbergioidin	34-43	D-amino acid oxidase	Homo sapiens	60-64
30554648-3	2019	d-amino acid oxidase (DAAO) catalyzes the oxidative deamination of d-amino acids (e.g. d-alanine), and H2O2 is evolved.	dalbergioidin	87-96	D-amino acid oxidase	Homo sapiens	22-26
30554648-11	2019	For the deamination of d-alanine, the catalytic efficiency of HDP&DAAO is 3.05 times that of DAAO.	dalbergioidin	23-32	D-amino acid oxidase	Homo sapiens	70-74
30554648-11	2019	For the deamination of d-alanine, the catalytic efficiency of HDP&DAAO is 3.05 times that of DAAO.	dalbergioidin	23-32	D-amino acid oxidase	Homo sapiens	97-101
29893546-3	2018	d-alanine is oxidized by d-amino acid oxidase (DAAO); thus, an inhibitor of DAAO would be expected to enhance d-alanine levels and likewise lead to desirable clinical outcomes.	dalbergioidin	0-9	D-amino acid oxidase	Homo sapiens	25-45
30569920-1	2019	In this paper, the d/l-AP5-interfaces are firstly fabricated by attaching d-alanine-pillar[5]arene and l-alanine-pillar[5]arene (d/l-AP5) onto the gold surface, and they exhibit a significantly different chiral influence on the morphology and the adsorption quantity of the adsorbed ctDNA molecules.	dalbergioidin	74-83	adaptor related protein complex 5 subunit beta 1	Homo sapiens	23-26
29893546-3	2018	d-alanine is oxidized by d-amino acid oxidase (DAAO); thus, an inhibitor of DAAO would be expected to enhance d-alanine levels and likewise lead to desirable clinical outcomes.	dalbergioidin	0-9	D-amino acid oxidase	Homo sapiens	47-51
29893546-3	2018	d-alanine is oxidized by d-amino acid oxidase (DAAO); thus, an inhibitor of DAAO would be expected to enhance d-alanine levels and likewise lead to desirable clinical outcomes.	dalbergioidin	0-9	D-amino acid oxidase	Homo sapiens	76-80
29893546-3	2018	d-alanine is oxidized by d-amino acid oxidase (DAAO); thus, an inhibitor of DAAO would be expected to enhance d-alanine levels and likewise lead to desirable clinical outcomes.	dalbergioidin	110-119	D-amino acid oxidase	Homo sapiens	25-45
29893546-3	2018	d-alanine is oxidized by d-amino acid oxidase (DAAO); thus, an inhibitor of DAAO would be expected to enhance d-alanine levels and likewise lead to desirable clinical outcomes.	dalbergioidin	110-119	D-amino acid oxidase	Homo sapiens	47-51
29893546-3	2018	d-alanine is oxidized by d-amino acid oxidase (DAAO); thus, an inhibitor of DAAO would be expected to enhance d-alanine levels and likewise lead to desirable clinical outcomes.	dalbergioidin	110-119	D-amino acid oxidase	Homo sapiens	76-80
29893546-7	2018	We reasoned that the cerebral spinal fluid d-alanine quantity is reflective of the brain d-alanine levels and it would increase as a consequence of DAAO inhibition with sodium benzoate.	dalbergioidin	43-52	D-amino acid oxidase	Homo sapiens	148-152
28836020-4	2017	The insoluble hDAAO codon variant displayed the same substrate specificity as the soluble one for oxidizing D-alanine, D-serine and D-aspartic acid.	dalbergioidin	108-117	D-amino acid oxidase	Homo sapiens	14-19
29964014-1	2018	Alanine racemase is a pyridoxal-5"-phosphate (PLP)-dependent enzyme that reversibly catalyzes the conversion of l-alanine to d-alanine.	dalbergioidin	125-134	alanine racemase	Pseudomonas aeruginosa PAO1	0-16
29867842-4	2018	At host-microbe interfaces in the neutrophils and intestinal mucosa, DAO catalyzes oxidation of bacterial D-amino acids, such as D-alanine, and generates H2O2, which is linked to antimicrobial activity.	dalbergioidin	129-138	D-amino acid oxidase	Homo sapiens	69-72
29255714-11	2017	Among the above d-amino acids, the main physiological substrates of mouse DAO are d-alanine and d-serine.	dalbergioidin	82-91	D-amino acid oxidase	Mus musculus	74-77
29255714-13	2017	d-Alanine derives from bacteria and produces bactericidal reactive oxygen species by the action of DAO.	dalbergioidin	0-9	D-amino acid oxidase	Mus musculus	99-102
29297750-9	2018	In addition, splenocytes from mice immunized with the D-alanine auxotroph vaccine showed specific production of IL-17A after ex vivo stimulation.	dalbergioidin	54-63	interleukin 17A	Mus musculus	112-118
29297750-10	2018	We conclude that this D-alanine auxotroph protects mice efficiently against virulent staphylococcal strains through the combined action of antibodies and IL-17A, and therefore constitutes a promising vaccine candidate against staphylococcal disease, for which no licensed vaccine is available yet.	dalbergioidin	22-31	interleukin 17A	Mus musculus	154-160
28813484-6	2017	Treatment of Mecp2tm1.1Jae/y mice with D-cycloserine (DCS), an FDA-approved analog of the amino acid D-alanine with antibiotic and glycinergic activity, corrected the presynaptic but not LTP deficit without affecting deficient hippocampal BDNF levels.	dalbergioidin	101-110	methyl CpG binding protein 2	Mus musculus	13-18
28284308-0	2017	Enzymatic biosensor based on entrapment of d-amino acid oxidase on gold nanofilm/MWCNTs nanocomposite modified glassy carbon electrode by sol-gel network: Analytical applications for d-alanine in human serum.	dalbergioidin	183-192	D-amino acid oxidase	Homo sapiens	43-63
28374099-6	2017	The potential molecular mechanism involved in the protective effect of DAL against H2O2-induced cell death in MC3T3-E1 cells may lie in the activation of the PI3K/AKT/SMAD1 cell signal pathway.	dalbergioidin	71-74	thymoma viral proto-oncogene 1	Mus musculus	163-166
28374099-6	2017	The potential molecular mechanism involved in the protective effect of DAL against H2O2-induced cell death in MC3T3-E1 cells may lie in the activation of the PI3K/AKT/SMAD1 cell signal pathway.	dalbergioidin	71-74	SMAD family member 1	Mus musculus	167-172
28284308-1	2017	Sensing and determination of d-alanine is studied by using an enzymatic biosensor which was constructed on the basis of d-amino acid oxidase (DAAO) immobilization by sol-gel film onto glassy carbon electrode surface modified with nanocomposite of gold nanofilm (Au-NF) and multiwalled carbon nanotubes (MWCNTs).	dalbergioidin	29-38	D-amino acid oxidase	Homo sapiens	120-140
28284308-1	2017	Sensing and determination of d-alanine is studied by using an enzymatic biosensor which was constructed on the basis of d-amino acid oxidase (DAAO) immobilization by sol-gel film onto glassy carbon electrode surface modified with nanocomposite of gold nanofilm (Au-NF) and multiwalled carbon nanotubes (MWCNTs).	dalbergioidin	29-38	D-amino acid oxidase	Homo sapiens	142-146
28159615-5	2017	When the two immobilized enzymes were used together in one pot, the transformation of (R)-1-phenylethylamine was catalyzed by the immobilized ELP-RTA, and the co-product d-alanine was converted back to pyruvate under the catalysis of the immobilized ELP-DAAO, achieving the recycling of pyruvate in situ.	dalbergioidin	170-179	nuclear receptor subfamily 5 group A member 1	Homo sapiens	142-145
28159615-5	2017	When the two immobilized enzymes were used together in one pot, the transformation of (R)-1-phenylethylamine was catalyzed by the immobilized ELP-RTA, and the co-product d-alanine was converted back to pyruvate under the catalysis of the immobilized ELP-DAAO, achieving the recycling of pyruvate in situ.	dalbergioidin	170-179	nuclear receptor subfamily 5 group A member 1	Homo sapiens	250-253
28159615-5	2017	When the two immobilized enzymes were used together in one pot, the transformation of (R)-1-phenylethylamine was catalyzed by the immobilized ELP-RTA, and the co-product d-alanine was converted back to pyruvate under the catalysis of the immobilized ELP-DAAO, achieving the recycling of pyruvate in situ.	dalbergioidin	170-179	D-amino acid oxidase	Homo sapiens	254-258
27287825-4	2016	One possible reason for the high dose is that D-alanine could be undergoing oxidation by D-amino acid oxidase (DAAO) before it reaches the brain.	dalbergioidin	46-55	D-amino acid oxidase	Homo sapiens	89-109
27740612-8	2016	A minimal supplement of D-Ala (150 mug mL-1) was required for the optimal growth of the alr mutant.	dalbergioidin	24-29	L1 cell adhesion molecule	Mus musculus	39-43
27287825-4	2016	One possible reason for the high dose is that D-alanine could be undergoing oxidation by D-amino acid oxidase (DAAO) before it reaches the brain.	dalbergioidin	46-55	D-amino acid oxidase	Homo sapiens	111-115
27287825-5	2016	If this is the case, the dose could be reduced by co-administration of D-alanine with a DAAO inhibitor (DAAOi).	dalbergioidin	71-80	D-amino acid oxidase	Homo sapiens	88-92
27287825-8	2016	The objective of the work reported herein was to confirm the hypothesis that DAAO inhibition can enhance D-alanine exposure in a species closer to humans: non-human primates.	dalbergioidin	105-114	D-amino acid oxidase	Homo sapiens	77-81
26024289-1	2016	Alanine racemase is a fold type III PLP-dependent amino acid racemase enzyme catalysing the conversion of l-alanine to d-alanine utilised by bacterial cell wall for peptidoglycan synthesis.	dalbergioidin	119-128	proteolipid protein 1	Homo sapiens	36-39
28100935-0	2016	Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-beta Signal Pathway.	dalbergioidin	0-13	transforming growth factor, beta 1	Mus musculus	80-88
26808406-4	2016	We demonstrate that AstC can efficiently catalyze the transfer of d-alanine to the C-11 hydroxyl group of ansatrienins, and AstF1 is able to attach the cyclohexanoyl group to the amino group of d-alanine.	dalbergioidin	66-75	aldo-keto reductase family 1 member C4	Homo sapiens	83-87
24821597-6	2014	POPC liposomes encapsulating DAO from porcine kidney selectively catalyzed the oxidation of hydrophobic D-phenylalanine (D-Phe) over D-Ala and D-Ser because of their intrinsic membrane permeability.	dalbergioidin	133-138	D-amino acid oxidase	Homo sapiens	29-32
27873678-5	2014	The bacterium develops resistance by modifying the C-terminal d-alanine of peptidoglycan to d-lactate, creating a d-Ala-d-Lac sequence that effectively reduces the affinity of vancomycin for the peptidoglycan by 1000-fold.	dalbergioidin	62-71	lactase	Homo sapiens	122-125
25425233-4	2014	We report that Salmonella limits exposure to oxidative damage elicited by D-amino acid oxidase (DAO) in neutrophils by expressing an ABC importer specific for D-alanine, a DAO substrate found in peptidoglycan stem peptides.	dalbergioidin	159-168	D-amino acid oxidase	Mus musculus	74-94
25425233-4	2014	We report that Salmonella limits exposure to oxidative damage elicited by D-amino acid oxidase (DAO) in neutrophils by expressing an ABC importer specific for D-alanine, a DAO substrate found in peptidoglycan stem peptides.	dalbergioidin	159-168	D-amino acid oxidase	Mus musculus	96-99
25425233-4	2014	We report that Salmonella limits exposure to oxidative damage elicited by D-amino acid oxidase (DAO) in neutrophils by expressing an ABC importer specific for D-alanine, a DAO substrate found in peptidoglycan stem peptides.	dalbergioidin	159-168	D-amino acid oxidase	Mus musculus	172-175
25425233-5	2014	A Salmonella dalS mutant defective for D-alanine import was more susceptible to killing by DAO through exposure to greater oxidative stress during infection.	dalbergioidin	39-48	D-amino acid oxidase	Mus musculus	91-94
25425233-10	2014	In this study, we show that D-amino acid oxidase (DAO) in neutrophils consumes D-alanine and that importing this substrate protects Salmonella from oxidative killing by neutrophil DAO.	dalbergioidin	79-88	D-amino acid oxidase	Mus musculus	28-48
25425233-10	2014	In this study, we show that D-amino acid oxidase (DAO) in neutrophils consumes D-alanine and that importing this substrate protects Salmonella from oxidative killing by neutrophil DAO.	dalbergioidin	79-88	D-amino acid oxidase	Mus musculus	50-53
23384700-5	2013	Fe3O4-APTES-DAAO caused a substantial decrease of cell viability greatly augmented when D-alanine, a DAAO substrate, was added.	dalbergioidin	88-97	D-amino acid oxidase	Homo sapiens	12-16
24013634-7	2013	The presence of dra led to the incorporation of d-alanine into an outer membrane component that is susceptible to proteinase K cleavage.	dalbergioidin	48-57	solute carrier family 26 member 3	Homo sapiens	16-19
23384700-5	2013	Fe3O4-APTES-DAAO caused a substantial decrease of cell viability greatly augmented when D-alanine, a DAAO substrate, was added.	dalbergioidin	88-97	D-amino acid oxidase	Homo sapiens	101-105
22194336-4	2012	As D-alanine is an essential component of the bacterial cell-wall peptidoglycan, inhibition of Alr is lethal to prokaryotes.	dalbergioidin	3-12	AT695_RS06560	Staphylococcus aureus	95-98
23391306-1	2013	D-amino acid oxidase (DAO) is a degradative enzyme that is stereospecific for D-amino acids, including D-serine and D-alanine, which are potential coagonists of the N-methyl-D-aspartate (NMDA) receptor.	dalbergioidin	116-125	D-amino acid oxidase	Homo sapiens	0-20
23391306-1	2013	D-amino acid oxidase (DAO) is a degradative enzyme that is stereospecific for D-amino acids, including D-serine and D-alanine, which are potential coagonists of the N-methyl-D-aspartate (NMDA) receptor.	dalbergioidin	116-125	D-amino acid oxidase	Homo sapiens	22-25
23391306-3	2013	Hence, a DAO inhibitor that augments the brain levels of D-serine and/or D-alanine and thereby activates NMDA receptor function is expected to be an antipsychotic drug, for instance, in the treatment of schizophrenia.	dalbergioidin	73-82	D-amino acid oxidase	Homo sapiens	9-12
23732868-3	2013	In the present study, the effects of the possible factors controlling the D-Ala amounts, e.g., diet, D-amino acid oxidase (DAO) and intestinal bacteria, on the day-night changes in the intrinsic D-Ala amounts have been investigated using a highly sensitive and selective two-dimensional high-performance liquid chromatographic system combining a reversed-phase column and an enantioselective column.	dalbergioidin	195-200	D-amino acid oxidase	Mus musculus	101-121
23732868-3	2013	In the present study, the effects of the possible factors controlling the D-Ala amounts, e.g., diet, D-amino acid oxidase (DAO) and intestinal bacteria, on the day-night changes in the intrinsic D-Ala amounts have been investigated using a highly sensitive and selective two-dimensional high-performance liquid chromatographic system combining a reversed-phase column and an enantioselective column.	dalbergioidin	195-200	D-amino acid oxidase	Mus musculus	123-126
23732868-5	2013	In the mice lacking D-amino acid oxidase activity (ddY/DAO(-) mice), clear day-night changes were still observed, suggesting that the factors controlling the D-Ala rhythm were not their food and DAO activity.	dalbergioidin	158-163	D-amino acid oxidase	Mus musculus	20-40
24019483-7	2013	Protein semisynthesis was used to introduce d-Alanine into the selectivity filters of the KcsA channel and the voltage-gated K(+) channel KvAP.	dalbergioidin	44-53	potassium voltage-gated channel subfamily D member 3	Homo sapiens	111-137
23603133-4	2013	The stability of DAAO was improved by adding free flavin adenine dinucleotide and the electrode composition was optimized for the detection of d-alanine.	dalbergioidin	143-152	D-amino acid oxidase	Homo sapiens	17-21
23199733-3	2013	OV-DAO and UV-DAO showed the activity to catalyze the oxidation of D-alanine as measured based on the hydrogen peroxide produced.	dalbergioidin	67-76	D-amino acid oxidase	Homo sapiens	3-6
23199733-3	2013	OV-DAO and UV-DAO showed the activity to catalyze the oxidation of D-alanine as measured based on the hydrogen peroxide produced.	dalbergioidin	67-76	D-amino acid oxidase	Homo sapiens	14-17
21720554-7	2011	Introduction of bpsl2179 on a multicopy plasmid into alanine racemase deficient variants of either Burkholderia species eliminated the requirement for D-alanine.	dalbergioidin	151-160	alr	Burkholderia mallei ATCC 23344	53-69
20851062-7	2011	These results indicate that the intrinsic amounts of D-Ser and D-Ala in the tissues of rats are regulated by DAO, and that LEA/Sen rats would be useful for the study of NMDA receptor-related diseases in which DAO is implicated.	dalbergioidin	63-68	D-amino-acid oxidase	Rattus norvegicus	109-112
20851062-7	2011	These results indicate that the intrinsic amounts of D-Ser and D-Ala in the tissues of rats are regulated by DAO, and that LEA/Sen rats would be useful for the study of NMDA receptor-related diseases in which DAO is implicated.	dalbergioidin	63-68	D-amino-acid oxidase	Rattus norvegicus	209-212
19586804-0	2009	Determination of D-serine and D-alanine in the tissues and physiological fluids of mice with various D-amino-acid oxidase activities using two-dimensional high-performance liquid chromatography with fluorescence detection.	dalbergioidin	30-39	D-amino acid oxidase	Mus musculus	101-121
19586804-9	2009	The present micro-2D-HPLC procedures are powerful tools for the determination of small amounts of D-Ser and D-Ala in mammalian samples, and the obtained results would be useful for developing novel drugs that modulate the DAO activity, such as DAO inhibitors, against neuronal diseases.	dalbergioidin	108-113	D-amino acid oxidase	Homo sapiens	222-225
17928431-5	2007	Ten times more of the synthetic structures with four to six d-alanine-substituted polyglycerophosphate units (50 nM) than of the native LTA preparation was required to induce IL-8 release.	dalbergioidin	60-69	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
19401780-11	2009	CONCLUSIONS/SIGNIFICANCE: This study has identified a novel mechanism for the reduced virulence of dltA mutants of Streptococcus pyogenes in which gene regulatory networks somehow sense and respond to the loss of DltA and lack of D-alanine esterification of lipoteichoic acid.	dalbergioidin	230-239	dihydrolipoamide S-acetyltransferase	Homo sapiens	99-103
19401780-11	2009	CONCLUSIONS/SIGNIFICANCE: This study has identified a novel mechanism for the reduced virulence of dltA mutants of Streptococcus pyogenes in which gene regulatory networks somehow sense and respond to the loss of DltA and lack of D-alanine esterification of lipoteichoic acid.	dalbergioidin	230-239	dihydrolipoamide S-acetyltransferase	Homo sapiens	213-217
18636195-0	2008	Transfection of the DAAO gene and subsequent induction of cytotoxic oxidative stress by D-alanine in 9L cells.	dalbergioidin	88-97	D-amino-acid oxidase	Rattus norvegicus	20-24
18636195-1	2008	D-amino acid oxidase (DAAO) can catalyze the dehydrogenation of D-amino acids, such as D-alanine, to the corresponding amino acids and is then reoxidized by molecular oxygen to yield hydrogen peroxide, a reactive oxygen species, which reacts with DNA, lipids and protein, inducing cell death.	dalbergioidin	87-96	D-amino-acid oxidase	Rattus norvegicus	0-20
18636195-1	2008	D-amino acid oxidase (DAAO) can catalyze the dehydrogenation of D-amino acids, such as D-alanine, to the corresponding amino acids and is then reoxidized by molecular oxygen to yield hydrogen peroxide, a reactive oxygen species, which reacts with DNA, lipids and protein, inducing cell death.	dalbergioidin	87-96	D-amino-acid oxidase	Rattus norvegicus	22-26
18636195-2	2008	This study investigated whether rat glioma 9L cells infected with the recombinant retrovirus containing the DAAO cDNA fragment can be induced in order to undergo cytotoxic oxidative stress by D-alanine.	dalbergioidin	192-201	D-amino-acid oxidase	Rattus norvegicus	108-112
18636195-5	2008	The cytotoxic oxidative stress of infected 9L cells was induced by the DAAO substrate, D-alanine.	dalbergioidin	87-96	D-amino-acid oxidase	Rattus norvegicus	71-75
18636195-10	2008	The DAAO/D-alanine system has a potential utility for gene therapy and may be an effective strategy for the treatment of brain cancer and other malignant tumors.	dalbergioidin	9-18	D-amino-acid oxidase	Rattus norvegicus	4-8
18184763-2	2008	To explore the role of ANG-(1-7) on fluid and electrolyte homeostasis during pregnancy, we evaluated the effect of the ANG-(1-7) antagonist D-alanine-[ANG-(1-7)] (A-779) on kidney function.	dalbergioidin	140-149	angiogenin	Rattus norvegicus	119-127
18184763-2	2008	To explore the role of ANG-(1-7) on fluid and electrolyte homeostasis during pregnancy, we evaluated the effect of the ANG-(1-7) antagonist D-alanine-[ANG-(1-7)] (A-779) on kidney function.	dalbergioidin	140-149	angiogenin	Rattus norvegicus	119-127
19198668-0	2008	Administration of D-Alanine-[Ang-(1-7)] (A-779) Prior to Pregnancy in Sprague Dawley Rats Produces Antidiuresis in Late Gestation.	dalbergioidin	18-27	angiogenin	Rattus norvegicus	29-37
19198668-2	2008	These previous studies were completed by chronic administration of the Ang-(1-7) receptor antagonist D-Alanine-[Ang-(1-7)] (A-779) at a dose of 48 mug/kg/hr after the start of pregnancy (gestational days 11-19).	dalbergioidin	101-110	angiogenin, ribonuclease A family, member 2	Rattus norvegicus	71-79
19198668-2	2008	These previous studies were completed by chronic administration of the Ang-(1-7) receptor antagonist D-Alanine-[Ang-(1-7)] (A-779) at a dose of 48 mug/kg/hr after the start of pregnancy (gestational days 11-19).	dalbergioidin	101-110	angiogenin	Rattus norvegicus	112-120
17005988-2	2006	An attenuated strain (Lmdd) with deletions in two genes (dal and dat) required for d-alanine synthesis and viability has been shown to induce long-lived protective systemic and mucosal immune responses in mice when administered in the presence of the required amino acid.	dalbergioidin	83-92	peptidase D	Mus musculus	57-60
17564608-4	2007	Insertional inactivation of the dltA gene resulted in complete depletion of D-alanine substitution of lipoteichoic acids.	dalbergioidin	76-85	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	Mus musculus	32-36
17293438-7	2007	Both ethyl methanesulfonate and T-DNA knockout plants identified as D-Ala resistant were found to be mutated in the LHT1 gene.	dalbergioidin	68-73	lysine histidine transporter 1	Arabidopsis thaliana	116-120
17293438-10	2007	Based on the broad and unbiased screening of mutants resistant to D-Ala, we suggest that LHT1 is an important mediator of root uptake of amino acids.	dalbergioidin	66-71	lysine histidine transporter 1	Arabidopsis thaliana	89-93
17005988-2	2006	An attenuated strain (Lmdd) with deletions in two genes (dal and dat) required for d-alanine synthesis and viability has been shown to induce long-lived protective systemic and mucosal immune responses in mice when administered in the presence of the required amino acid.	dalbergioidin	83-92	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	65-68
16885447-8	2006	In addition, mild alkaline hydrolysis of heat-inactivated whole cells released d-alanine from dltA-proficient strains, but not from dltA mutants.	dalbergioidin	79-88	dltA	Streptococcus pneumoniae R6	94-98
16707184-10	2006	The high substrate specificity of the Alr from C. glutamicum ATCC 13032 is expected to be a biocatalyst for d-alanine production from the l-counter part.	dalbergioidin	108-117	alanine racemase	Corynebacterium glutamicum ATCC 13032	38-41
16751595-2	2006	A DAO mutant, in which I215-N225 is substituted by R216-G220 of DDO, showed D-aspartate-oxidizing activity that wild-type DAO does not exhibit, together with a considerable decrease in activity toward D-alanine.	dalbergioidin	201-210	D-amino acid oxidase	Homo sapiens	2-5
16751595-2	2006	A DAO mutant, in which I215-N225 is substituted by R216-G220 of DDO, showed D-aspartate-oxidizing activity that wild-type DAO does not exhibit, together with a considerable decrease in activity toward D-alanine.	dalbergioidin	201-210	D-aspartate oxidase	Homo sapiens	64-67
15450847-2	2004	To assess its role in catalysis, it was mutated to Gly, the residue present in mammalian DAAO, an enzyme with a 35-fold lower turnover number with D-alanine.	dalbergioidin	147-156	D-amino acid oxidase	Homo sapiens	89-93
15058991-3	2004	In comparing the kinetic parameters determined for the three DAAOs, with both cephalosporin C and d-alanine as substrate, the catalytic efficiency of the two enzymes from microorganism is at least 2 orders of magnitude higher than that of pig kidney DAAO.	dalbergioidin	98-107	D-amino acid oxidase	Sus scrofa	61-65