PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28365474-3	2017	Further evaluations were performed to increase TDAG8 expression 6h prior to middle cerebral artery occlusion (MCAO) by injecting a specific agonist, BTB09089, into the lateral ventricle to increase TDAG8 expression.	3-((2,4-dichlorobenzyl)thio)-1,6-dimethyl-5,6-dihydro-1H-pyridazino(4,5-e)(1,3,4)thiadiazin-5-one	149-157	G-protein coupled receptor 65	Rattus norvegicus	47-52
28365474-3	2017	Further evaluations were performed to increase TDAG8 expression 6h prior to middle cerebral artery occlusion (MCAO) by injecting a specific agonist, BTB09089, into the lateral ventricle to increase TDAG8 expression.	3-((2,4-dichlorobenzyl)thio)-1,6-dimethyl-5,6-dihydro-1H-pyridazino(4,5-e)(1,3,4)thiadiazin-5-one	149-157	G-protein coupled receptor 65	Rattus norvegicus	198-203
28365474-8	2017	Pretreatment with BTB09089 up-regulated TDAG8 and Bcl-2 expression and down-regulated cleaved caspase-3 expression, while the infarction volume was reduced, and neurological deficits were ameliorated 24 and 72h after MCAO.	3-((2,4-dichlorobenzyl)thio)-1,6-dimethyl-5,6-dihydro-1H-pyridazino(4,5-e)(1,3,4)thiadiazin-5-one	18-26	G-protein coupled receptor 65	Rattus norvegicus	40-45
28365474-8	2017	Pretreatment with BTB09089 up-regulated TDAG8 and Bcl-2 expression and down-regulated cleaved caspase-3 expression, while the infarction volume was reduced, and neurological deficits were ameliorated 24 and 72h after MCAO.	3-((2,4-dichlorobenzyl)thio)-1,6-dimethyl-5,6-dihydro-1H-pyridazino(4,5-e)(1,3,4)thiadiazin-5-one	18-26	BCL2, apoptosis regulator	Rattus norvegicus	50-55
28365474-8	2017	Pretreatment with BTB09089 up-regulated TDAG8 and Bcl-2 expression and down-regulated cleaved caspase-3 expression, while the infarction volume was reduced, and neurological deficits were ameliorated 24 and 72h after MCAO.	3-((2,4-dichlorobenzyl)thio)-1,6-dimethyl-5,6-dihydro-1H-pyridazino(4,5-e)(1,3,4)thiadiazin-5-one	18-26	caspase 3	Rattus norvegicus	94-103
22445881-7	2012	Thus, BTB09089 was found to be a TDAG8 specific agonist.	3-((2,4-dichlorobenzyl)thio)-1,6-dimethyl-5,6-dihydro-1H-pyridazino(4,5-e)(1,3,4)thiadiazin-5-one	6-14	G-protein coupled receptor 65	Mus musculus	33-38
22445881-9	2012	In splenocytes, BTB09089 suppressed the production of IL-2 stimulated with anti-CD3 and anti-CD28 antibodies.	3-((2,4-dichlorobenzyl)thio)-1,6-dimethyl-5,6-dihydro-1H-pyridazino(4,5-e)(1,3,4)thiadiazin-5-one	16-24	interleukin 2	Mus musculus	54-58
22445881-10	2012	In peritoneal exuded macrophages induced by thioglycollate, BTB09089 suppressed the production of TNF-alpha and IL-6 while it increased that of IL-10 when stimulated with lipopolysaccharide.	3-((2,4-dichlorobenzyl)thio)-1,6-dimethyl-5,6-dihydro-1H-pyridazino(4,5-e)(1,3,4)thiadiazin-5-one	60-68	tumor necrosis factor	Mus musculus	98-107
22445881-9	2012	In splenocytes, BTB09089 suppressed the production of IL-2 stimulated with anti-CD3 and anti-CD28 antibodies.	3-((2,4-dichlorobenzyl)thio)-1,6-dimethyl-5,6-dihydro-1H-pyridazino(4,5-e)(1,3,4)thiadiazin-5-one	16-24	CD28 antigen	Mus musculus	93-97
22445881-10	2012	In peritoneal exuded macrophages induced by thioglycollate, BTB09089 suppressed the production of TNF-alpha and IL-6 while it increased that of IL-10 when stimulated with lipopolysaccharide.	3-((2,4-dichlorobenzyl)thio)-1,6-dimethyl-5,6-dihydro-1H-pyridazino(4,5-e)(1,3,4)thiadiazin-5-one	60-68	interleukin 6	Mus musculus	112-116
22445881-10	2012	In peritoneal exuded macrophages induced by thioglycollate, BTB09089 suppressed the production of TNF-alpha and IL-6 while it increased that of IL-10 when stimulated with lipopolysaccharide.	3-((2,4-dichlorobenzyl)thio)-1,6-dimethyl-5,6-dihydro-1H-pyridazino(4,5-e)(1,3,4)thiadiazin-5-one	60-68	interleukin 10	Mus musculus	144-149