PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
26477318-7	2016	Unexpectedly, loss of N-cadherin in the K-ras(G12D) model resulted in increased mPanIN progression and tumor incidence.	mpanin	80-86	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	40-45
26477318-4	2016	Genetic ablation of N-cadherin (N-cad KO) caused hyperproliferation, accelerated mPanIN progression, and early tumor development in K-ras(G12D) mice.	mpanin	81-87	cadherin 2	Mus musculus	20-30
23749643-9	2013	Thus, with oncogenic Ras expressed in the pancreas, HIF2alpha modulates Wnt-signaling during mPanIN progression by maintaining appropriate levels of both Smad4 and beta-catenin.	mpanin	93-99	endothelial PAS domain protein 1	Homo sapiens	52-61
26477318-7	2016	Unexpectedly, loss of N-cadherin in the K-ras(G12D) model resulted in increased mPanIN progression and tumor incidence.	mpanin	80-86	cadherin 2	Mus musculus	22-32
22945649-5	2013	Furthermore, AGR2 is coexpressed with MUC1 in mouse pancreatic intraepithelial neoplasia (mPanIN)-like lesions and in the cancer cells of four distinct genetically engineered mouse models of PDAC.	mpanin	90-96	anterior gradient 2	Mus musculus	13-17
22945649-6	2013	We also show that Pdx1-Cre/LSL-Kras(G12D)/Smad4(lox/lox) mice heterozygous for Agr2 exhibit a delay in mPanIN initiation and progression to PDAC.	mpanin	103-109	pancreatic and duodenal homeobox 1	Mus musculus	18-22
22945649-6	2013	We also show that Pdx1-Cre/LSL-Kras(G12D)/Smad4(lox/lox) mice heterozygous for Agr2 exhibit a delay in mPanIN initiation and progression to PDAC.	mpanin	103-109	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	31-35
22945649-6	2013	We also show that Pdx1-Cre/LSL-Kras(G12D)/Smad4(lox/lox) mice heterozygous for Agr2 exhibit a delay in mPanIN initiation and progression to PDAC.	mpanin	103-109	SMAD family member 4	Mus musculus	42-47
22945649-6	2013	We also show that Pdx1-Cre/LSL-Kras(G12D)/Smad4(lox/lox) mice heterozygous for Agr2 exhibit a delay in mPanIN initiation and progression to PDAC.	mpanin	103-109	lysyl oxidase	Mus musculus	48-51
22945649-6	2013	We also show that Pdx1-Cre/LSL-Kras(G12D)/Smad4(lox/lox) mice heterozygous for Agr2 exhibit a delay in mPanIN initiation and progression to PDAC.	mpanin	103-109	anterior gradient 2	Mus musculus	79-83
22945649-7	2013	It is proposed that loss of Smad4 may convert TGF-beta from a tumor suppressor to a tumor promoter by causing the upregulation of AGR2, which then leads to increased MUC1 expression, at which point both AGR2 and MUC1 facilitate mPanIN initiation and progression to PDAC.	mpanin	228-234	SMAD family member 4	Mus musculus	28-33
22945649-7	2013	It is proposed that loss of Smad4 may convert TGF-beta from a tumor suppressor to a tumor promoter by causing the upregulation of AGR2, which then leads to increased MUC1 expression, at which point both AGR2 and MUC1 facilitate mPanIN initiation and progression to PDAC.	mpanin	228-234	transforming growth factor, beta 1	Mus musculus	46-54
22945649-7	2013	It is proposed that loss of Smad4 may convert TGF-beta from a tumor suppressor to a tumor promoter by causing the upregulation of AGR2, which then leads to increased MUC1 expression, at which point both AGR2 and MUC1 facilitate mPanIN initiation and progression to PDAC.	mpanin	228-234	anterior gradient 2	Mus musculus	130-134
22945649-7	2013	It is proposed that loss of Smad4 may convert TGF-beta from a tumor suppressor to a tumor promoter by causing the upregulation of AGR2, which then leads to increased MUC1 expression, at which point both AGR2 and MUC1 facilitate mPanIN initiation and progression to PDAC.	mpanin	228-234	anterior gradient 2	Mus musculus	203-207
22945649-7	2013	It is proposed that loss of Smad4 may convert TGF-beta from a tumor suppressor to a tumor promoter by causing the upregulation of AGR2, which then leads to increased MUC1 expression, at which point both AGR2 and MUC1 facilitate mPanIN initiation and progression to PDAC.	mpanin	228-234	mucin 1, transmembrane	Mus musculus	212-216
21611096-3	2011	Pancreas epithelium-specific endogenous Kras activation develops murine pancreatic intraepithelial neoplasia (mPanIN).	mpanin	110-116	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	40-44
21455033-4	2011	Both CB and CBP mice developed non-invasive ductal precursor lesions (murine pancreatic intraepithelial neoplasia or mPanIN), although these were observed at an earlier time point (5 versus 8 months) and with higher prevalence in CBP mice.	mpanin	117-123	phosphoprotein associated with glycosphingolipid microdomains 1	Mus musculus	12-15
21611096-4	2011	Additional inactivation of p16, p53, or transforming growth factor-beta signaling, in the context of Kras activation, dramatically accelerates mPanIN progression to invasive pancreatic ductal adenocarcinoma (PDAC) with abundant stromal expansion and marked fibrosis (desmoplasia).	mpanin	143-149	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	27-30
21611096-4	2011	Additional inactivation of p16, p53, or transforming growth factor-beta signaling, in the context of Kras activation, dramatically accelerates mPanIN progression to invasive pancreatic ductal adenocarcinoma (PDAC) with abundant stromal expansion and marked fibrosis (desmoplasia).	mpanin	143-149	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	101-105
20807812-7	2010	Our data support a dosage-dependent role for PTEN, and the resulting dysregulation of the PI3K/AKT signaling axis, in both PDAC initiation and progression, and shed additional light on the signaling mechanisms that lead to the development of ADM and subsequent mPanIN and pancreatic cancer.	mpanin	261-267	phosphatase and tensin homolog	Mus musculus	45-49
19249398-4	2009	METHODS: In this study, we examined the importance of the acinar-restricted transcription factor Mist1 to KrasG12D-induced mouse PanIN (mPanIN) formation in 3 different mouse models of pancreatic cancer.	mpanin	136-142	basic helix-loop-helix family, member a15	Mus musculus	97-102
19249398-6	2009	mPanIN development was greatly accelerated in Mist1KO/KrasG12D/+ pancreata, and in vitro assays revealed that Mist1KO acinar cells were predisposed to convert to a ductal phenotype and activate epidermal growth factor receptor (EGFR) and Notch-signaling pathways.	mpanin	0-6	basic helix-loop-helix family, member a15	Mus musculus	46-53
19249398-6	2009	mPanIN development was greatly accelerated in Mist1KO/KrasG12D/+ pancreata, and in vitro assays revealed that Mist1KO acinar cells were predisposed to convert to a ductal phenotype and activate epidermal growth factor receptor (EGFR) and Notch-signaling pathways.	mpanin	0-6	basic helix-loop-helix family, member a15	Mus musculus	46-51
19249398-7	2009	CONCLUSIONS: We propose that convergence of EGFR, Notch, and Kras pathways in acinar cells lacking Mist1 leads to enhanced mPanIN formation.	mpanin	123-129	epidermal growth factor receptor	Mus musculus	44-48
19249398-7	2009	CONCLUSIONS: We propose that convergence of EGFR, Notch, and Kras pathways in acinar cells lacking Mist1 leads to enhanced mPanIN formation.	mpanin	123-129	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	61-65
19249398-7	2009	CONCLUSIONS: We propose that convergence of EGFR, Notch, and Kras pathways in acinar cells lacking Mist1 leads to enhanced mPanIN formation.	mpanin	123-129	basic helix-loop-helix family, member a15	Mus musculus	99-104
17804724-5	2007	Analysis of double-mutant mice showed that loss of Smad4 significantly accelerated the progression of pancreatic intraepithelial neoplasias (mPanIN) and promoted a high incidence of intraductal papillary mucinous neoplasia and active fibrosis compared with Pdx1-Cre;Kras(G12D) or Pdx1-Cre;Smad4(lox/lox) mice.	mpanin	141-147	SMAD family member 4	Mus musculus	51-56
19028870-4	2008	The most faithful genetic models activate an oncogenic Kras(G12D) knockin allele within the pdx1- or ptf1a/p48-expression domain of the entire pancreatic anlage during development, thus obscuring the putative cell(s)-of-origin from which subsequent mPanIN lesions arise.	mpanin	249-255	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	55-59
19028870-5	2008	In our study, activation of this knockin Kras(G12D) allele in the Elastase- and Mist1-expressing mature acinar compartment of adult mice resulted in the spontaneous induction of mPanIN lesions of all histological grades, although invasive carcinomas per se were not seen.	mpanin	178-184	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	41-45
19028870-5	2008	In our study, activation of this knockin Kras(G12D) allele in the Elastase- and Mist1-expressing mature acinar compartment of adult mice resulted in the spontaneous induction of mPanIN lesions of all histological grades, although invasive carcinomas per se were not seen.	mpanin	178-184	basic helix-loop-helix family, member a15	Mus musculus	80-85
19028870-8	2008	In contrast to the uniformly penetrant mPanIN phenotype observed following developmental activation of Kras(G12D) in the Pdx1-expressing progenitor cells, the Pdx1-expressing population in the mature pancreas (predominantly islet beta cells) appears to be relatively resistant to the effects of oncogenic Kras.	mpanin	39-45	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	103-107
17785207-3	2007	We show that concomitant expression of TGFalpha and Kras(G12D) accelerates the progression of mPanIN lesions to metastatic pancreatic cancer and leads to the development of cystic papillary lesions resembling human intraductal papillary mucinous neoplasms (IPMN).	mpanin	94-100	transforming growth factor alpha	Homo sapiens	39-47
17785207-3	2007	We show that concomitant expression of TGFalpha and Kras(G12D) accelerates the progression of mPanIN lesions to metastatic pancreatic cancer and leads to the development of cystic papillary lesions resembling human intraductal papillary mucinous neoplasms (IPMN).	mpanin	94-100	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	52-56
17591971-8	2007	Indeed, immunofluorescence studies confirmed the presence of acinar cells within mPanIN lesions, raising the possibility that Kras(G12D)-induced mPanINs develop from acinar cells that undergo acinar-ductal metaplasia.	mpanin	81-87	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	126-130