PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
17929845-5	2007	The BDD/(NO3-) interface was the only N2O and N2 species generating system.	Nitrous Oxide	38-41	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
18212564-0	2008	Intermitted pharmacologic pretreatment by xenon, isoflurane, nitrous oxide, and the opioid morphine prevents tumor necrosis factor alpha-induced adhesion molecule expression in human umbilical vein endothelial cells.	Nitrous Oxide	61-74	tumor necrosis factor	Homo sapiens	109-136
18199125-4	2008	We encountered that nrc mutants of denitrifying strains show a decrease in anaerobic growth rates not only with nitrate, but also with nitrite, NO and N(2)O, which is concomitant to their lower NADH oxidation activities in vitro.	Nitrous Oxide	151-156	nuclear receptor coactivator 6	Homo sapiens	20-23
17852555-8	2008	Albumin radicals (HSA) generated under N2O inactivated GAPDH and ADH more effectively than haemoglobin radicals (Hb).	Nitrous Oxide	39-42	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	55-60
18379989-5	2008	HMP expression has been demonstrated to respond to the presence of NO in the culture medium, and an explicit mechanism has been proposed that involves NO scavenging and its reduction to N(2)O under anaerobic conditions.	Nitrous Oxide	186-191	inner membrane mitochondrial protein	Homo sapiens	0-3
17951609-0	2007	Impaired vitamin B12 metabolic status in healthcare workers occupationally exposed to nitrous oxide.	Nitrous Oxide	86-99	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	17-20
17951609-1	2007	BACKGROUND: Previous studies demonstrated inactivation of vitamin B12 by nitrous oxide (N(2)O).	Nitrous Oxide	73-86	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	66-69
17951609-10	2007	However, subjects exposed to N(2)O presented with lower vitamin B12 [372.8 (12.1) vs 436.8 (13.2) pmol litre(-1), P<0.001] and higher tHcy [11.2 (0.5) vs 8.9 (0.5) micromol litre(-1), P=0.006].	Nitrous Oxide	29-34	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	64-67
17951609-11	2007	The changes in vitamin B12 status were aggravated in subjects exposed to N(2)O in concentrations substantially exceeding occupational exposure limit (180 mg m(-3)) [vitamin B12: 341.9 (17.7) vs 436.8 (13.2) pmol litre(-1), P=0.006; tHcy: 12.9 (0.7) vs 8.9 (0.5) micromol litre(-1), P=0.047].	Nitrous Oxide	73-78	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	23-26
17951609-11	2007	The changes in vitamin B12 status were aggravated in subjects exposed to N(2)O in concentrations substantially exceeding occupational exposure limit (180 mg m(-3)) [vitamin B12: 341.9 (17.7) vs 436.8 (13.2) pmol litre(-1), P=0.006; tHcy: 12.9 (0.7) vs 8.9 (0.5) micromol litre(-1), P=0.047].	Nitrous Oxide	73-78	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	173-176
17979338-0	2007	Ab initio calculations of nitrogen oxide reactions: formation of N2O2, N2O3, N2O4, N2O5, and N4O2 from NO, NO2, NO3, and N2O.	Nitrous Oxide	65-68	NBL1, DAN family BMP antagonist	Homo sapiens	112-115
17620835-4	2007	In contrast, nitrous oxide, xenon, and ketamine produce analgesia, but weak hypnosis and amnesia, by inhibiting glutamate and nicotinic receptors and activating potassium "leak" channels such as TREK-1.	Nitrous Oxide	13-26	potassium two pore domain channel subfamily K member 2	Homo sapiens	195-201
17681696-6	2007	The prolonged exposure to 70% N2O caused an activation of PKCgamma isoform in the brain, but not the PKCepsilon isoform.	Nitrous Oxide	30-33	protein kinase C, gamma	Mus musculus	58-66
17681696-13	2007	Thus, activation of brain PKC, in particular, the PKCgamma isoform, appears to play an important role in the development of both acute tolerance and cross-tolerance to N2O-induced antinociception in mice.	Nitrous Oxide	168-171	protein kinase C, gamma	Mus musculus	50-58
17683399-1	2007	Although often felt to be relatively innocuous, nitrous oxide can have significant metabolic effects in settings of abnormal vitamin B12 and B12-related metabolism in children.	Nitrous Oxide	48-61	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	133-136
17683399-1	2007	Although often felt to be relatively innocuous, nitrous oxide can have significant metabolic effects in settings of abnormal vitamin B12 and B12-related metabolism in children.	Nitrous Oxide	48-61	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	141-144
17659475-3	2007	There are six main families of K2P channels and among these certain members of the TREK family (ie, TREK-1 and TREK-2) are activated by general anesthetic agents such as halothane, xenon and nitrous oxide.	Nitrous Oxide	191-204	keratin 76	Homo sapiens	31-34
17578961-0	2007	Nitrous oxide decreases cortical methionine synthase transiently but produces lasting memory impairment in aged rats.	Nitrous Oxide	0-13	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	33-52
17578961-1	2007	BACKGROUND: Nitrous oxide is a commonly used anesthetic that inhibits the activity of methionine synthase, an enzyme involved in methylation reactions and DNA synthesis and repair.	Nitrous Oxide	12-25	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	86-105
17578961-5	2007	RESULTS: Liver and cortical methionine synthase was inhibited during nitrous oxide inhalation (6% and 23% of control in liver and cortex, respectively; P < 0.01).	Nitrous Oxide	69-82	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	28-47
17578961-9	2007	CONCLUSIONS: Sedation with 70% nitrous oxide profoundly, but transiently, reduces the activity of cortical methionine synthase but produces lasting impairment in spatial working memory in aged rats.	Nitrous Oxide	31-44	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	107-126
17659475-3	2007	There are six main families of K2P channels and among these certain members of the TREK family (ie, TREK-1 and TREK-2) are activated by general anesthetic agents such as halothane, xenon and nitrous oxide.	Nitrous Oxide	191-204	potassium two pore domain channel subfamily K member 2	Homo sapiens	83-87
17659475-3	2007	There are six main families of K2P channels and among these certain members of the TREK family (ie, TREK-1 and TREK-2) are activated by general anesthetic agents such as halothane, xenon and nitrous oxide.	Nitrous Oxide	191-204	potassium two pore domain channel subfamily K member 2	Homo sapiens	100-106
17659475-3	2007	There are six main families of K2P channels and among these certain members of the TREK family (ie, TREK-1 and TREK-2) are activated by general anesthetic agents such as halothane, xenon and nitrous oxide.	Nitrous Oxide	191-204	potassium two pore domain channel subfamily K member 10	Homo sapiens	111-117
17112259-2	2006	Efficient electron transfer (>19%) is observed with CS2, NH3, C6F6, NO2, NO*, and C6H6, molecular addition occurs with D2O, CH4, CH3F, CH3Cl, and OCS, and SF6, CO, CO2, N2O, and O2 showed no measurable reactivity with Hg*+.	Nitrous Oxide	172-175	chorionic somatomammotropin hormone 2	Homo sapiens	55-58
17561102-6	2007	When IR was performed in the presence of N(2)O, obviating H(2)O(2) production and increasing hydroxyl radical ((*)OH) production, the Yap1 response was lost, indicating that Yap1 was unable to respond to (*)OH or (*)OH-induced damage.	Nitrous Oxide	41-46	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	134-138
17561102-6	2007	When IR was performed in the presence of N(2)O, obviating H(2)O(2) production and increasing hydroxyl radical ((*)OH) production, the Yap1 response was lost, indicating that Yap1 was unable to respond to (*)OH or (*)OH-induced damage.	Nitrous Oxide	41-46	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	174-178
17123554-0	2007	Nitrous oxide (N2O) pre- and postsynaptically attenuates NMDA receptor-mediated neurotransmission in the amygdala.	Nitrous Oxide	0-13	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	57-70
17123554-0	2007	Nitrous oxide (N2O) pre- and postsynaptically attenuates NMDA receptor-mediated neurotransmission in the amygdala.	Nitrous Oxide	15-18	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	57-70
17123554-7	2007	In addition, our data speak in favour of a N(2)O-produced reduction in the probability of glutamate release at the synapses generating the NMDAR-EPSCs.	Nitrous Oxide	43-48	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	139-144
17404524-7	2007	CONCLUSIONS: The inactivation of methionine synthase and L methylmalonylcoA mutase by nitrous oxide has been previously demonstrated.	Nitrous Oxide	86-99	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	33-52
17125297-8	2006	In contrast, no such barrier is evident for S-atom transfer from the valence isolectronic CS2 molecule which proceeds at unit efficiency, and this is attributed to the much higher polarizability of CS2 compared to CO2 and N2O.	Nitrous Oxide	222-225	chorionic somatomammotropin hormone 2	Homo sapiens	90-93
17388299-1	2007	Ab initio calculations at MP2/6-311++G(2d,2p) and MP2/6-311++G(3df,3pd) computational levels have been used to analyze the interactions between nitrous oxide and a series of small and large molecules that act simultaneously as hydrogen bond donors and electron donors.	Nitrous Oxide	144-157	tryptase pseudogene 1	Homo sapiens	26-29
17388299-1	2007	Ab initio calculations at MP2/6-311++G(2d,2p) and MP2/6-311++G(3df,3pd) computational levels have been used to analyze the interactions between nitrous oxide and a series of small and large molecules that act simultaneously as hydrogen bond donors and electron donors.	Nitrous Oxide	144-157	tryptase pseudogene 1	Homo sapiens	50-53
17028130-7	2007	Comparison of the effects of Xe and N(2)O on urate oxidase and annexin V reveals an interesting relationship with the in vivo pharmacological effects of these gases, the ratio of the gas-binding sites" volume expansion and the ratio of the narcotic potency being similar.	Nitrous Oxide	36-41	annexin A5	Homo sapiens	63-72
16626191-0	2006	Vibrational and rotational energy transfers involving the CH B 2Sigma(-) v=1 vibrational level in collisions with Ar, CO, and N2O.	Nitrous Oxide	126-129	immunoglobulin kappa variable 1-5	Homo sapiens	73-76
16931689-0	2006	The involvement of the nociceptin receptor in the antinociceptive action of nitrous oxide.	Nitrous Oxide	76-89	opioid receptor-like 1	Mus musculus	23-42
16931689-4	2006	Using the acetic acid-induced writhing test, we showed that nitrous oxide had significantly less analgesic action in NOP-/- mice than in NOP+/+ mice.	Nitrous Oxide	60-73	crystallin, gamma B	Mus musculus	117-120
16931689-5	2006	Furthermore, when anesthetized with a mixture of halothane and nitrous oxide (70%), intraperitoneal injection of acetic acid resulted in an increase of plasma adrenocorticotropic hormone concentrations in NOP-/- mice but not in NOP+/+ mice.	Nitrous Oxide	63-76	pro-opiomelanocortin-alpha	Mus musculus	159-186
16931689-5	2006	Furthermore, when anesthetized with a mixture of halothane and nitrous oxide (70%), intraperitoneal injection of acetic acid resulted in an increase of plasma adrenocorticotropic hormone concentrations in NOP-/- mice but not in NOP+/+ mice.	Nitrous Oxide	63-76	crystallin, gamma B	Mus musculus	205-208
16931689-5	2006	Furthermore, when anesthetized with a mixture of halothane and nitrous oxide (70%), intraperitoneal injection of acetic acid resulted in an increase of plasma adrenocorticotropic hormone concentrations in NOP-/- mice but not in NOP+/+ mice.	Nitrous Oxide	63-76	crystallin, gamma B	Mus musculus	228-231
16931689-6	2006	An immunohistochemical study showed that nitrous oxide exposure induced c-Fos expression in the spinal cords of NOP+/+ mice but not in those of NOP-/- mice.	Nitrous Oxide	41-54	FBJ osteosarcoma oncogene	Mus musculus	72-77
16931689-6	2006	An immunohistochemical study showed that nitrous oxide exposure induced c-Fos expression in the spinal cords of NOP+/+ mice but not in those of NOP-/- mice.	Nitrous Oxide	41-54	crystallin, gamma B	Mus musculus	112-115
16903725-3	2006	All complexes consist of end-on azido and syn-syn carboxylato mixed-bridged M-N(3)/COO chains that are further linked by the pyridine N-oxide group of the INO or NNO to give rise to 2D layered structures for 1.Mn, 2.Co, 3.Ni, 4.Mn, 5.Co, 6.Ni, and 8.Cu and a 3D framework for 7.Cu.	Nitrous Oxide	162-165	synemin	Homo sapiens	42-45
16627294-4	2006	The NOX and ClOX chains involve the emission at Earth"s surface of stable molecules in very low concentration (N2O, CCl2F2, CCl3F, etc.)	Nitrous Oxide	111-114	cut like homeobox 1	Homo sapiens	12-16
16733980-2	2006	In Dutch dentistry, nitrous-oxide sedation is a valuable and indispensable aid in the treatment of patients with challenging behaviour, such as those with mental impairment or in extremely-anxious adults and children.	Nitrous Oxide	20-33	activation induced cytidine deaminase	Homo sapiens	75-78
16703352-7	2006	Under the same conditions MNX produced N2O and HCHO together with trace amounts of DNX and TNX, but we were unable to detect MEDINA.	Nitrous Oxide	39-42	keratin 86	Homo sapiens	26-29
16790648-8	2006	On days 1 and 3, the concentration of Bax was 140%-200% larger in fentanyl/N2O-anesthetized animals compared with sevoflurane.	Nitrous Oxide	75-78	BCL2 associated X, apoptosis regulator	Rattus norvegicus	38-41
16337819-5	2006	The results justify the hypothesis of the adduct formation and show that only in case of S-ligands the higher contribution of the Fe(III)-NO(-) components in adduct than in RBS is observed, which on excitation can undergo heterolytic cleavage yielding Fe(III) and NO(-), converted rapidly into N(2)O.	Nitrous Oxide	294-299	establishment of sister chromatid cohesion N-acetyltransferase 2	Homo sapiens	173-176
16597953-0	2006	Symbiotic Bradyrhizobium japonicum reduces N2O surrounding the soybean root system via nitrous oxide reductase.	Nitrous Oxide	43-46	chalcone reductase CHR1	Glycine max	101-110
16585613-8	2006	Similarly, N2O and CH4 fluxes were predominantly controlled by NO3- content and labile C and N availability in both ST and NT soils at field moisture content, and NH4+ content after irrigation.	Nitrous Oxide	11-14	NBL1, DAN family BMP antagonist	Homo sapiens	63-66
16597953-1	2006	N(2)O reductase activity in soybean nodules formed with Bradyrhizobium japonicum was evaluated from N(2)O uptake and conversion of (15)N-N(2)O into (15)N-N(2).	Nitrous Oxide	0-5	SDR family oxidoreductase	Bradyrhizobium diazoefficiens USDA 110	6-15
16597953-6	2006	These results indicate that the conversion of N(2)O to N(2) depends exclusively on the respiratory N(2)O reductase and that soybean roots nodulated with B. japonicum carrying the nos genes are able to remove very low concentrations of N(2)O.	Nitrous Oxide	46-51	chalcone reductase CHR1	Glycine max	105-114
16491901-6	2006	Anesthesia was maintained with 2-3% sevoflurane in 1 l x min(-1) of oxygen and 2 l x min(-1) of nitrous oxide.	Nitrous Oxide	96-109	CD59 molecule (CD59 blood group)	Homo sapiens	85-91
16417519-3	2006	Escherichia coli flavorubredoxin and its associated oxidoreductase, encoded by the norV and norW genes respectively, reduces NO to nitrous oxide under anaerobic conditions.	Nitrous Oxide	131-144	oxidoreductase	Escherichia coli	52-66
16361298-3	2006	Because of this uncommon clinical presentation, we analysed the patient"s DNA, and found a polymorphism in the MTHFR gene that is associated with the thermolabile isoform of the 5,10-methylenetetrahydrofolate reductase enzyme, which explained the myelopathy experienced by the patient after being exposed to nitrous oxide.	Nitrous Oxide	308-321	methylenetetrahydrofolate reductase	Homo sapiens	111-116
16306729-3	2005	The authors aimed to clarify (1) whether nitrous oxide preconditions the heart, (2) how it affects protein kinase C (PKC) and tyrosine kinases (such as Src) as central mediators of preconditioning, and (3) whether isoflurane-induced preconditioning is influenced by nitrous oxide.	Nitrous Oxide	41-54	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	152-155
16306729-3	2005	The authors aimed to clarify (1) whether nitrous oxide preconditions the heart, (2) how it affects protein kinase C (PKC) and tyrosine kinases (such as Src) as central mediators of preconditioning, and (3) whether isoflurane-induced preconditioning is influenced by nitrous oxide.	Nitrous Oxide	266-279	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	152-155
15920196-3	2005	Although the NR3B subunit prominently reduced the current amplitude of NR1/NR2A-B channels, the sensitivities of NR1/NR2A-B channels to Mg2+, ketamine, isoflurane, nitrous oxide, and ethanol were not altered by coexpression of the NR3B subunit.	Nitrous Oxide	164-177	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	113-116
16234931-0	2005	Formation of a cytochrome c-nitrous oxide reductase complex is obligatory for N2O reduction by Paracoccus pantotrophus.	Nitrous Oxide	78-81	cytochrome c, somatic	Equus caballus	15-27
16234931-8	2005	We propose that a conformational change in N2OR is induced by its specific interaction with cytochrome c that in turn either permits electron transfer between CuA and CuZ or controls the rate of N2O decomposition at the active site.	Nitrous Oxide	43-46	cytochrome c, somatic	Equus caballus	92-104
16240026-6	2005	NO3 uptake performed on small amounts of Kaolinite and CaCO3 leads to formation of some N2O5 according to NO((3ads)) + NO(2(g)) --> N2O(5(ads)) --> N2O(5(g)).	Nitrous Oxide	88-91	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
16240026-6	2005	NO3 uptake performed on small amounts of Kaolinite and CaCO3 leads to formation of some N2O5 according to NO((3ads)) + NO(2(g)) --> N2O(5(ads)) --> N2O(5(g)).	Nitrous Oxide	135-138	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
16833861-1	2005	Scandium monoxide-dinitrogen complexes-OSc(N2), OScNN, and OScNN+-have been prepared by the reactions of laser-evaporated scandium monoxide with N2 or scandium atoms with N2O in solid argon.	Nitrous Oxide	171-174	lanosterol synthase	Homo sapiens	39-45
16182898-1	2005	BACKGROUND: Nitrous oxide inactivates vitamin B12 and methionine synthase, thereby impairing DNA formation and, consequently, new cell formation.	Nitrous Oxide	12-25	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	46-49
16182898-1	2005	BACKGROUND: Nitrous oxide inactivates vitamin B12 and methionine synthase, thereby impairing DNA formation and, consequently, new cell formation.	Nitrous Oxide	12-25	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	54-73
15993935-0	2005	Correlation of inbred mouse sensitivity to nitrous oxide antinociception with brain nitric oxide synthase activity following exposure to nitrous oxide.	Nitrous Oxide	43-56	nitric oxide synthase 1, neuronal	Mus musculus	84-105
15993935-0	2005	Correlation of inbred mouse sensitivity to nitrous oxide antinociception with brain nitric oxide synthase activity following exposure to nitrous oxide.	Nitrous Oxide	137-150	nitric oxide synthase 1, neuronal	Mus musculus	84-105
15993935-1	2005	Inhibition of nitric oxide synthase (NOS) antagonizes nitrous oxide (N2O)-induced antinociception in mice.	Nitrous Oxide	54-67	nitric oxide synthase 1, neuronal	Mus musculus	14-35
15993935-1	2005	Inhibition of nitric oxide synthase (NOS) antagonizes nitrous oxide (N2O)-induced antinociception in mice.	Nitrous Oxide	69-72	nitric oxide synthase 1, neuronal	Mus musculus	14-35
16027666-4	2005	However, to initiate prehospital analgesia earlier in the EMS response time frame, EMT"s should administer nitrous oxide/oxygen.	Nitrous Oxide	107-120	IL2 inducible T cell kinase	Homo sapiens	83-86
15899276-6	2005	The N2O:N2 ratios increased rapidly when NO3- increased from 63 to 363 microM; however, results from monthly surveys showed that environmental parameters other than NO3- availability may be important in controlling the variation in N2O production via denitrification.	Nitrous Oxide	4-7	NBL1, DAN family BMP antagonist	Homo sapiens	41-44
15811665-7	2005	Finally, when evaluating the lower flammability limit, it was found that pure nitrous oxide decomposes at pressures above 4.5 bara when applying an ignition energy of about 10 J.	Nitrous Oxide	78-91	lin-9 DREAM MuvB core complex component	Homo sapiens	126-130
15861320-4	2004	Recent research has revealed a link between statins and the serine/threonine protein kinase Akt that regulates multiple angiogenic processes in endothelial cells, including the generation of nitrous oxide.	Nitrous Oxide	191-204	AKT serine/threonine kinase 1	Homo sapiens	92-95
16833590-8	2005	The bare dipositive actinyl ions, UO2(2+), NpO2(2+), and PuO2(2+), were produced from the oxidation of the corresponding AnO2+ by N2O, and by O2 in the cases of UO2+ and NpO2+.	Nitrous Oxide	130-133	anoctamin 2	Homo sapiens	121-125
16851119-3	2005	Over Na-Y, the reaction between HCN and NO(2) is slow at 473 K. On Ba-Y, HCN reacts readily with NO(2) at 473K, forming N(2), CO, CO(2), HNCO, NO, N(2)O, and C(2)N(2).	Nitrous Oxide	147-152	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	32-35
16851119-3	2005	Over Na-Y, the reaction between HCN and NO(2) is slow at 473 K. On Ba-Y, HCN reacts readily with NO(2) at 473K, forming N(2), CO, CO(2), HNCO, NO, N(2)O, and C(2)N(2).	Nitrous Oxide	147-152	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	73-76
15486012-3	2005	One particular member of the family, TREK-1 (also known as KCNK2), is activated by increasing temperature, membrane stretch and internal acidosis, but is also sensitive to the presence of certain polyunsaturated fatty acids (such as arachidonic acid), neuroprotectants (such as riluzole) and volatile and gaseous general anaesthetics (such as halothane and nitrous oxide).	Nitrous Oxide	357-370	potassium two pore domain channel subfamily K member 2	Homo sapiens	37-43
15486012-3	2005	One particular member of the family, TREK-1 (also known as KCNK2), is activated by increasing temperature, membrane stretch and internal acidosis, but is also sensitive to the presence of certain polyunsaturated fatty acids (such as arachidonic acid), neuroprotectants (such as riluzole) and volatile and gaseous general anaesthetics (such as halothane and nitrous oxide).	Nitrous Oxide	357-370	potassium two pore domain channel subfamily K member 2	Homo sapiens	59-64
15537939-8	2004	Attempts to identify RDX degradates and reaction products showed that N(2)O was a product of permanganate oxidation and constituted 20 to 30% of the N balance.	Nitrous Oxide	70-75	radixin	Homo sapiens	21-24
15667300-2	2005	The Escherichia coli flavorubredoxin and its associated oxidoreductase reduce NO to nitrous oxide under anaerobic conditions, and are encoded by the norVW transcription unit.	Nitrous Oxide	84-97	oxidoreductase	Escherichia coli	56-70
16158577-0	2005	Preliminary studies on nitrous oxide emissions from the ornithogenic soils on Xi-sha atoll, South China Sea.	Nitrous Oxide	23-36	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	104-107
16295918-9	2005	The study also revealed that the emissions of N2O were affected by the application of organic manures in the order of P2 > S2 > C2 > P1 > S1 > Cl > CK1 > CK2.	Nitrous Oxide	46-49	Calcium-dependent protein kinase 6	Zea mays	175-178
15669350-3	2004	In the absence of O2, CL-20 underwent a rapid decomposition with the concurrent formation of nitrite to ultimately produce nitrous oxide, ammonium, formate, glyoxal, and glycolate.	Nitrous Oxide	123-136	epithelial membrane protein 1	Homo sapiens	22-27
15669350-8	2004	The present experimental findings suggest that CL-20 degraded via at least two initial routes: one involving denitration and the second involving sequential reduction of the N-NO2 to the corresponding nitroso (N-NO) derivatives prior to denitration and ring cleavage.	Nitrous Oxide	174-178	epithelial membrane protein 1	Homo sapiens	47-52
15549976-5	2004	However, in contrast, nitrous oxide was found to decrease the mean arterial pressure (from 81 (8) to 69 (7) mmHg), the LVSWI, and the FAC.	Nitrous Oxide	22-35	FA complementation group C	Homo sapiens	134-137
15491653-4	2004	Presently, we found that photolysis of the rigid molecule CL-20 produced NO2-, NO3-, NH3, HCOOH, N2 and N2O.	Nitrous Oxide	104-107	epithelial membrane protein 1	Homo sapiens	58-63
15087624-1	2004	BACKGROUND: The objective of this study was to determine whether endothelin-A receptor blockade (ETAB) impairs hemodynamic and hormonal regulation compared with controls and angiotensin II receptor blockade (AT1B) during hypotensive hemorrhage in dogs under isoflurane-nitrous oxide anesthesia.	Nitrous Oxide	269-282	endothelin receptor type A	Canis lupus familiaris	65-86
15496295-0	2004	General anesthetics inhibit the nitrous-oxide-induced activation of corticotropin releasing factor containing neurons in rats.	Nitrous Oxide	32-45	corticotropin releasing hormone	Rattus norvegicus	68-98
15496295-1	2004	The activation of intracerebral corticotropin releasing factor (CRF) system is involved in nitrous oxide analgesia.	Nitrous Oxide	91-104	corticotropin releasing hormone	Rattus norvegicus	32-62
15196804-0	2004	Antagonism of nitrous oxide antinociception in mice by antisense oligodeoxynucleotide directed against neuronal nitric oxide synthase enzyme.	Nitrous Oxide	14-27	nitric oxide synthase 1, neuronal	Mus musculus	103-133
15196804-2	2004	This study was conducted to determine the sensitivity of N2O-induced antinociception to antagonism by an antisense oligodeoxynucleotide (AS-ODN) against neuronal nitric oxide synthase (nNOS).	Nitrous Oxide	57-60	nitric oxide synthase 1, neuronal	Mus musculus	153-183
15196804-2	2004	This study was conducted to determine the sensitivity of N2O-induced antinociception to antagonism by an antisense oligodeoxynucleotide (AS-ODN) against neuronal nitric oxide synthase (nNOS).	Nitrous Oxide	57-60	nitric oxide synthase 1, neuronal	Mus musculus	185-189
15196804-4	2004	This result implicates the specific involvement of nNOS in N2O-induced antinociception.	Nitrous Oxide	59-62	nitric oxide synthase 1, neuronal	Mus musculus	51-55
15159532-7	2004	The N(2)O-resistant nmr-1(null) mutant was not resistant to VAs.	Nitrous Oxide	4-9	LITAF domain-containing protein	Caenorhabditis elegans	20-25
15159532-9	2004	Thus, the behavioral effects of N(2)O require the NMDA receptor NMR-1, consistent with the hypothesis formed from vertebrate electrophysiological data that a major target of N(2)O is the NMDA receptor.	Nitrous Oxide	32-37	LITAF domain-containing protein	Caenorhabditis elegans	64-69
15159532-9	2004	Thus, the behavioral effects of N(2)O require the NMDA receptor NMR-1, consistent with the hypothesis formed from vertebrate electrophysiological data that a major target of N(2)O is the NMDA receptor.	Nitrous Oxide	174-179	LITAF domain-containing protein	Caenorhabditis elegans	64-69
15174944-0	2004	Role of cyclic GMP in nitrous-oxide-induced anxiolytic-like behavior in the mouse light-dark exploration test.	Nitrous Oxide	22-35	5'-nucleotidase, cytosolic II	Mus musculus	15-18
19471742-10	2004	Group filled with nitrous oxide had pressures decreased below 20 cmH2O after 20 to 30 minutes of anesthesia.	Nitrous Oxide	18-31	troponin T2, cardiac type	Homo sapiens	65-69
15114213-9	2004	The percent alive CA1 neurons in the fentanyl-nitrous oxide group increased with duration of recovery (P = 0.004).	Nitrous Oxide	46-59	carbonic anhydrase 1	Rattus norvegicus	18-21
15087625-1	2004	BACKGROUND: Nitrous oxide and dexmedetomidine are thought to mediate analgesia (antinociception in a noncommunicative organism) via alpha 2B- and alpha 2A-adrenergic receptor subtypes within the spinal cord, respectively.	Nitrous Oxide	12-25	adrenoceptor alpha 2B	Rattus norvegicus	132-174
15087625-11	2004	Prazosin, the alpha 1-/alpha 2B-adrenoceptor antagonist, attenuated the analgesic effect of nitrous oxide and prevented dexmedetomidine-induced reversal of tolerance to nitrous oxide.	Nitrous Oxide	92-105	adrenoceptor alpha 2B	Rattus norvegicus	14-44
15087625-11	2004	Prazosin, the alpha 1-/alpha 2B-adrenoceptor antagonist, attenuated the analgesic effect of nitrous oxide and prevented dexmedetomidine-induced reversal of tolerance to nitrous oxide.	Nitrous Oxide	169-182	adrenoceptor alpha 2B	Rattus norvegicus	14-44
14742687-4	2004	TREK-1 is markedly activated by clinically relevant concentrations of nitrous oxide, xenon, and cyclopropane.	Nitrous Oxide	70-83	potassium two pore domain channel subfamily K member 2	Homo sapiens	0-6
15290416-12	2004	CONCLUSION: The results suggest that N(2)O can suppress the absolute amplitude of the MEP in patients under propofol and fentanyl anesthesia.	Nitrous Oxide	37-42	neurolysin	Homo sapiens	86-89
14750721-4	2004	The accumulation of NO2-, the absence of detectable NH4+ accumulation, and the production of N2O during in situ acetylene-block experiments suggest that NO3- was being consumed via denitrification.	Nitrous Oxide	93-96	NBL1, DAN family BMP antagonist	Homo sapiens	153-156
15005300-6	2004	Mean bias for oxygen and nitrous oxide uptake was 0.003 l min(-1), for isoflurane 0.0001 l min(-1) and for carbon dioxide 0.001 l min(-1).	Nitrous Oxide	25-38	CD59 molecule (CD59 blood group)	Homo sapiens	58-64
12795136-5	2003	In this case, anesthesia was induced with sevoflurane and gradually increased to 5% in oxygen 4 l.min-1 and maintained with sevoflurane 2-3% in 2 nitrous oxide l.min-1 and 2 l.min-1 oxygen.	Nitrous Oxide	146-159	CD59 molecule (CD59 blood group)	Homo sapiens	162-173
14768562-2	2003	At the same time the correlation of plant N2O emission with nitrate reductase activity, nitrate content and nitrite content of the plant leaves was also analyzed.	Nitrous Oxide	42-45	inducible nitrate reductase [NADH] 1	Glycine max	60-77
14768562-5	2003	The flux of plant N2O emission was significantly correlated (R2 > or = 0.97, n = 6) with the nitrate reductase activities, nitrate content and nitrite content of the maize and soybean leaves.	Nitrous Oxide	18-21	nitrate reductase [NADH] 1	Zea mays	96-113
12960557-0	2003	Corticotropin-releasing factor mediates the antinociceptive action of nitrous oxide in rats.	Nitrous Oxide	70-83	corticotropin releasing hormone	Rattus norvegicus	0-30
12960557-2	2003	Because corticotropin-releasing factor (CRF) can produce activation of noradrenergic neurons in the locus ceruleus, the authors sought to determine whether it might be responsible for the antinociceptive action of nitrous oxide.	Nitrous Oxide	214-227	corticotropin releasing hormone	Rattus norvegicus	8-38
12960557-6	2003	RESULTS: Inhalation of nitrous oxide induced a dose-dependent increase in c-Fos expression in CRF-positive neurons in the paraventricular nucleus of the hypothalamus.	Nitrous Oxide	23-36	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	74-79
12960557-7	2003	Intracerebroventricular administration of CRF antagonist inhibited nitrous oxide-induced c-Fos expression in the locus ceruleus and the antinociceptive effect of nitrous oxide.	Nitrous Oxide	67-80	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	89-94
12721331-0	2003	Role of nitric-oxide synthase isoforms in nitrous oxide antinociception in mice.	Nitrous Oxide	42-55	nitric oxide synthase 1, neuronal	Mus musculus	8-29
12721331-1	2003	Exposure of mice to the anesthetic gas N2O evokes a prominent antinociceptive effect that is sensitive to antagonism by nonselective nitric-oxide synthase (NOS) inhibitors.	Nitrous Oxide	39-42	nitric oxide synthase 1, neuronal	Mus musculus	133-154
12803265-5	2003	Intracuff nitrous oxide concentrations increased during repeated cuff deflation and increased further in Group Def-3 during an additional 3 h (from 39.8 +/- 4.7% to 44.3 +/- 3.8%; P < 0.05), whereas intracuff nitrous oxide concentrations at 4 h were not different from those in Group Def-4 at the end of the study (43.7 +/- 4.5% versus 42.3 +/- 4.8%; P = 0.579).	Nitrous Oxide	10-23	defensin alpha 3	Homo sapiens	111-116
12803265-5	2003	Intracuff nitrous oxide concentrations increased during repeated cuff deflation and increased further in Group Def-3 during an additional 3 h (from 39.8 +/- 4.7% to 44.3 +/- 3.8%; P < 0.05), whereas intracuff nitrous oxide concentrations at 4 h were not different from those in Group Def-4 at the end of the study (43.7 +/- 4.5% versus 42.3 +/- 4.8%; P = 0.579).	Nitrous Oxide	212-225	defensin alpha 3	Homo sapiens	111-116
12717145-9	2003	Midazolam inhibited N(2)O-induced c-Fos expression (a marker of neuronal activation) in the pontine A7 and spinal cord.	Nitrous Oxide	20-25	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	34-39
12775055-4	2003	Most of the remaining C and N content of RDX, MNX, and HMX was found in HCHO, N2O, HCOOH, and NH3.	Nitrous Oxide	78-81	keratin 86	Homo sapiens	46-49
15080355-7	2004	RESULTS: The most common effects of nitrous oxide sedation were open hands (90%), limp legs (81%), and facial smile (66%).	Nitrous Oxide	36-49	transmembrane O-mannosyltransferase targeting cadherins 3	Homo sapiens	110-115
14508330-6	2003	Microinjection of either naloxone or muscimol into the A7 nuclei also inhibited N2O-induced c-Fos expression in the spinal cord and the N2O-induced antinociceptive effect by the plantar test.	Nitrous Oxide	80-83	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	92-97
12680700-1	2003	To show the effects of growth inhibitory factor (Cu4Zn3MT-III) involved in the scavenging of reactive oxygen species (ROS), a pulse radiolytic study was employed using N2O-saturated Cu4Zn3MT-III aqueous solutions.	Nitrous Oxide	168-171	metallothionein 3	Homo sapiens	23-47
12644275-0	2003	Antisense knockdown of neuronal nitric oxide synthase antagonizes nitrous oxide-induced behavior.	Nitrous Oxide	66-79	nitric oxide synthase 1, neuronal	Mus musculus	23-53
12644275-1	2003	The behavioral effects of nitrous oxide (N(2)O) were antagonized by non-specific inhibitors of nitric oxide synthase (NOS).	Nitrous Oxide	26-39	nitric oxide synthase 1, neuronal	Mus musculus	95-116
12644275-1	2003	The behavioral effects of nitrous oxide (N(2)O) were antagonized by non-specific inhibitors of nitric oxide synthase (NOS).	Nitrous Oxide	41-47	nitric oxide synthase 1, neuronal	Mus musculus	95-116
14621157-6	2003	PO4(3-) and NH4+ content significantly enhanced, and NO2- and NO3- content inhibited, both N2O and CH4 fluxes.	Nitrous Oxide	91-94	NBL1, DAN family BMP antagonist	Homo sapiens	62-65
12751548-1	2003	Nitrous oxide interacts with vitamin B12 resulting in selective inhibition of methionine synthase, a key enzyme in methionine and folate metabolism.	Nitrous Oxide	0-13	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	78-97
12566486-8	2003	Exposing rats to an atmosphere containing N(2)O results in inactivation of methionine synthase and accumulation of 5-methyltetrahydrofolate at the expense of other folate coenzymes.	Nitrous Oxide	42-47	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	75-94
12866801-0	2003	Effect of nitrous oxide on intracellular events of GT1-7 GnRH-secreting neurons.	Nitrous Oxide	10-23	beta-1,4-galactosyltransferase 1	Homo sapiens	51-56
12866801-0	2003	Effect of nitrous oxide on intracellular events of GT1-7 GnRH-secreting neurons.	Nitrous Oxide	10-23	gonadotropin releasing hormone 1	Homo sapiens	57-61
12866801-2	2003	This study explored direct effects of N2O on gonadotropin-releasing hormone (GnRH) neurons involved in pituitary-gonadal function.	Nitrous Oxide	38-41	gonadotropin releasing hormone 1	Homo sapiens	45-75
12866801-2	2003	This study explored direct effects of N2O on gonadotropin-releasing hormone (GnRH) neurons involved in pituitary-gonadal function.	Nitrous Oxide	38-41	gonadotropin releasing hormone 1	Homo sapiens	77-81
12866801-3	2003	An immortalized GnRH-secreting GT1-7 cell line was used to evaluate the effects of 60% N2O exposure for 24 hours on pro-GnRH mRNA levels, KCl-stimulated GnRH levels, and certain signaling pathways.	Nitrous Oxide	87-90	gonadotropin releasing hormone 1	Mus musculus	120-124
12866801-3	2003	An immortalized GnRH-secreting GT1-7 cell line was used to evaluate the effects of 60% N2O exposure for 24 hours on pro-GnRH mRNA levels, KCl-stimulated GnRH levels, and certain signaling pathways.	Nitrous Oxide	87-90	gonadotropin releasing hormone 1	Mus musculus	120-124
12866801-4	2003	N2O exposure for 24 hours decreased pro-GnRH mRNA levels by approximately 80% without affecting cell viability or intracellular GnRH levels.	Nitrous Oxide	0-3	gonadotropin releasing hormone 1	Homo sapiens	40-44
12866801-6	2003	Western blot analyses of ERK1/2, and p38 phosphorylation and IkappaB did not indicate any change in phosphorylation, although p63 tyrosine phosphorylation was increased after short-term N2O exposure.	Nitrous Oxide	186-189	tumor protein p63	Homo sapiens	126-129
12866801-8	2003	These results indicate that N2O significantly decreases evoked release of GnRH as well as GnRH mRNA levels either by decreased synthesis or by mRNA stability.	Nitrous Oxide	28-31	gonadotropin releasing hormone 1	Homo sapiens	74-78
12866801-8	2003	These results indicate that N2O significantly decreases evoked release of GnRH as well as GnRH mRNA levels either by decreased synthesis or by mRNA stability.	Nitrous Oxide	28-31	gonadotropin releasing hormone 1	Homo sapiens	90-94
14699893-0	2003	Correlation of inbred mouse responsiveness to nitrous oxide (N2O) with brain nitric oxide synthase (NOS) activity.	Nitrous Oxide	46-59	nitric oxide synthase 1, neuronal	Mus musculus	77-98
14699893-0	2003	Correlation of inbred mouse responsiveness to nitrous oxide (N2O) with brain nitric oxide synthase (NOS) activity.	Nitrous Oxide	61-64	nitric oxide synthase 1, neuronal	Mus musculus	77-98
12589527-1	2003	RATIONALE: Previous studies have shown the anxiolytic-like effects of nitrous oxide (N(2)O) to be sensitive to antagonism by non-specific inhibitors of nitric oxide synthase (NOS).	Nitrous Oxide	70-83	nitric oxide synthase 1, neuronal	Mus musculus	152-173
12650967-0	2003	Nitrous oxide-induced c-Fos expression in the rat brain.	Nitrous Oxide	0-13	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	22-27
12650967-5	2003	N(2)O administration produced significant (P<0.05) dose-related increases of c-Fos expression in several forebrain regions, including the hypothalamic supraoptic and paraventricular nuclei, the thalamic paraventricular nucleus, the amygdala, and in retrosplenial cortex.	Nitrous Oxide	0-5	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	80-85
12650967-6	2003	In the midbrain, N(2)O caused significant dose-related c-Fos expression in the Edinger-Westphal nucleus.	Nitrous Oxide	17-22	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	55-60
12650967-7	2003	Finally, the pontine locus coeruleus, and two medullary regions, the nucleus of the solitary tract and ventrolateral medulla, also showed significant dose-related N(2)O-induced c-Fos expression.	Nitrous Oxide	163-168	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	177-182
12650967-9	2003	The overlapping pattern of c-Fos induced by ethanol and N(2)O suggests that these drugs may cause comparable central activity by acting on similar neuronal pathways.	Nitrous Oxide	56-61	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	27-32
19475251-7	2003	RESULTS: N2O administrated at 30% and 50% concentrations has statistically changed BIS, SEF1, SEF2, PE and OAA/S level of sedation in the studied moments.	Nitrous Oxide	9-12	transcription factor 4	Homo sapiens	94-98
15049275-6	2003	One of the most important is the endothelium derive relaxing factor (EDRF), which has been identified as endogenous nitrous oxide (NO).	Nitrous Oxide	116-129	alpha hemoglobin stabilizing protein	Homo sapiens	33-67
15049275-6	2003	One of the most important is the endothelium derive relaxing factor (EDRF), which has been identified as endogenous nitrous oxide (NO).	Nitrous Oxide	116-129	alpha hemoglobin stabilizing protein	Homo sapiens	69-73
12377178-4	2002	Remifentanil increased rCBF above all in basal ganglia, whereas in supratentorial gray matter the increase in rCBF was equal or even more pronounced when using nitrous oxide.	Nitrous Oxide	160-173	CCAAT/enhancer binding protein zeta	Rattus norvegicus	110-114
12401615-5	2002	Although the number of c-fos-positive cells in the lumbar spinal cord in the nitrous oxide group was not decreased, that in the xenon group decreased.	Nitrous Oxide	77-90	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	23-28
12459672-1	2002	BACKGROUND: In a previous study, the authors found that nitrous oxide (N2O) exposure induces c-Fos (an immunohistochemical marker of neuronal activation) in spinal cord gamma-aminobutyric acid-mediated (GABAergic) neurons in Fischer rats.	Nitrous Oxide	56-69	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	93-98
12459672-1	2002	BACKGROUND: In a previous study, the authors found that nitrous oxide (N2O) exposure induces c-Fos (an immunohistochemical marker of neuronal activation) in spinal cord gamma-aminobutyric acid-mediated (GABAergic) neurons in Fischer rats.	Nitrous Oxide	71-74	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	93-98
12459672-7	2002	N2O exposure induced c-Fos expression in the spinal cord, which was blocked by prazosin and naloxone but not by other drugs.	Nitrous Oxide	0-3	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	21-26
12459672-8	2002	N2O-induced c-Fos expression was colocalized with alpha1 adrenoceptor immunoreactivity in laminae III-IV.	Nitrous Oxide	0-3	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	12-17
12393773-7	2002	Both nitrous oxide and ketamine dose-dependently increased c-Fos expression in PC/RS cortices; in contrast, xenon produced no significant effect.	Nitrous Oxide	5-18	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	59-64
11978125-4	2002	UV-vis spectrophotometry and mass spectroscopy were used to show that Cbl(I) reduces NO to form Cbl(II)-NO and N(2)O and N(2), and this reaction is involved in the cyclic voltammetry of cobalamin in the presence of excess NO where a catalytic reduction of NO occurs involving the cycling of Cbl(II)-NO/Cbl(I).	Nitrous Oxide	111-116	Cbl proto-oncogene	Homo sapiens	70-73
12200115-3	2002	The removal of RDX was accompanied by the formation and accumulation of nitrite ion (NO(2)(-)), formaldehyde (HCHO), ammonium (NH(4)(+)), and nitrous oxide (N(2)O).	Nitrous Oxide	142-155	radixin	Homo sapiens	15-18
12142249-12	2002	Because nitrous oxide inhibits smooth muscle cells and evidence in laboratory animals indicates that expression of the inducible form of nitrous oxide (iNOS) is downregulated in myometrium, but upregulated in the cervix around the onset of parturition, we started to investigate the role of this enzyme in bovine tissues around calving.	Nitrous Oxide	8-21	nitric oxide synthase 2	Bos taurus	152-156
12142249-12	2002	Because nitrous oxide inhibits smooth muscle cells and evidence in laboratory animals indicates that expression of the inducible form of nitrous oxide (iNOS) is downregulated in myometrium, but upregulated in the cervix around the onset of parturition, we started to investigate the role of this enzyme in bovine tissues around calving.	Nitrous Oxide	137-150	nitric oxide synthase 2	Bos taurus	152-156
12106805-2	2002	This study was conducted to determine the influence of the NO donor, 3-morpholinosyndnonimine (SIN-1), on resting and nitrous oxide (N(2)O)-induced behaviors in the mouse light/dark exploration test.	Nitrous Oxide	118-131	MAPK associated protein 1	Homo sapiens	95-100
12106805-5	2002	When pretreated with 0.1 microg SIN-1, mice responded to N(2)O with an apparent additive increase in the time spent in the light compartment.	Nitrous Oxide	57-62	mitogen-activated protein kinase associated protein 1	Mus musculus	32-37
11978125-4	2002	UV-vis spectrophotometry and mass spectroscopy were used to show that Cbl(I) reduces NO to form Cbl(II)-NO and N(2)O and N(2), and this reaction is involved in the cyclic voltammetry of cobalamin in the presence of excess NO where a catalytic reduction of NO occurs involving the cycling of Cbl(II)-NO/Cbl(I).	Nitrous Oxide	111-116	Cbl proto-oncogene	Homo sapiens	291-301
12058442-10	2002	In the present patient with DRPLA, propofol, fentanyl, nitrous oxide, naloxone, and neostigmine administered might be factors, which could have lowered the threshold for seizure activity.	Nitrous Oxide	55-68	atrophin 1	Homo sapiens	28-33
12221873-5	2002	Moreover, the STH/hydrocortisone ratio was 2-fold higher in the Xe group vs. N2O + phentanyl group.	Nitrous Oxide	77-80	saitohin	Homo sapiens	14-17
11981177-0	2002	Does nitrous oxide really induce c-Fos expression related to its analgesic effect?	Nitrous Oxide	5-18	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	33-38
11502893-0	2001	Ca(v)3.2 channel is a molecular substrate for inhibition of T-type calcium currents in rat sensory neurons by nitrous oxide.	Nitrous Oxide	110-123	immunoglobulin lambda variable 7-43	Homo sapiens	0-8
11812695-5	2002	Sn Pdi decreased by 15.4% during nitrous oxide inhalation, with a value of 136 +/- 21 cm H(2)O before nitrous oxide and a value of 115 +/- 27 cm H(2)O during nitrous oxide inhalation (P = 0.03).	Nitrous Oxide	33-46	peptidyl arginine deiminase 1	Homo sapiens	3-6
11812695-5	2002	Sn Pdi decreased by 15.4% during nitrous oxide inhalation, with a value of 136 +/- 21 cm H(2)O before nitrous oxide and a value of 115 +/- 27 cm H(2)O during nitrous oxide inhalation (P = 0.03).	Nitrous Oxide	102-115	peptidyl arginine deiminase 1	Homo sapiens	3-6
11812695-5	2002	Sn Pdi decreased by 15.4% during nitrous oxide inhalation, with a value of 136 +/- 21 cm H(2)O before nitrous oxide and a value of 115 +/- 27 cm H(2)O during nitrous oxide inhalation (P = 0.03).	Nitrous Oxide	102-115	peptidyl arginine deiminase 1	Homo sapiens	3-6
11812695-6	2002	Similarly, Tw Pdi decreased from 21.2 +/- 1.8 cm H(2)O before nitrous oxide inhalation to 16.9 +/- 4.1 cm H(2)O during nitrous oxide inhalation (P = 0.03).	Nitrous Oxide	62-75	peptidyl arginine deiminase 1	Homo sapiens	14-17
11812695-6	2002	Similarly, Tw Pdi decreased from 21.2 +/- 1.8 cm H(2)O before nitrous oxide inhalation to 16.9 +/- 4.1 cm H(2)O during nitrous oxide inhalation (P = 0.03).	Nitrous Oxide	119-132	peptidyl arginine deiminase 1	Homo sapiens	14-17
11837439-9	2002	There was an increase in N2O release as the overlying water NO3- concentration increased.	Nitrous Oxide	25-28	NBL1, DAN family BMP antagonist	Homo sapiens	60-63
11840671-9	2002	However, the changes in SBP and HR at incision were significantly suppressed by addition of N2O (changes in SBP and HR: 41.6 +/- 20.4 mmHg and 35.4 +/- 12.5 bpm in the sevoflurane group vs. 24.6 +/- 10.2 mmHg and 18.1 +/- 9.5 bpm in the sevoflurane/N2O group, P < 0.01).	Nitrous Oxide	92-95	selenium binding protein 1	Homo sapiens	24-27
11840671-9	2002	However, the changes in SBP and HR at incision were significantly suppressed by addition of N2O (changes in SBP and HR: 41.6 +/- 20.4 mmHg and 35.4 +/- 12.5 bpm in the sevoflurane group vs. 24.6 +/- 10.2 mmHg and 18.1 +/- 9.5 bpm in the sevoflurane/N2O group, P < 0.01).	Nitrous Oxide	92-95	selenium binding protein 1	Homo sapiens	108-111
11840671-9	2002	However, the changes in SBP and HR at incision were significantly suppressed by addition of N2O (changes in SBP and HR: 41.6 +/- 20.4 mmHg and 35.4 +/- 12.5 bpm in the sevoflurane group vs. 24.6 +/- 10.2 mmHg and 18.1 +/- 9.5 bpm in the sevoflurane/N2O group, P < 0.01).	Nitrous Oxide	249-252	selenium binding protein 1	Homo sapiens	24-27
11758334-4	2001	Anesthesia was induced with sevoflurane slowly increased to 5% in nitrous oxide 3 l.min-1 with oxygen 3 l.min-1.	Nitrous Oxide	66-79	CD59 molecule (CD59 blood group)	Homo sapiens	84-89
11553360-1	2001	In previous studies using Fos expression as a marker of neuronal activation, we showed that nitrous oxide (N(2)O) activates bulbospinal noradrenergic neurons in rats and that destruction of these neuronal pathways leads to loss of N(2)O antinociceptive action.	Nitrous Oxide	92-105	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	26-29
11553360-1	2001	In previous studies using Fos expression as a marker of neuronal activation, we showed that nitrous oxide (N(2)O) activates bulbospinal noradrenergic neurons in rats and that destruction of these neuronal pathways leads to loss of N(2)O antinociceptive action.	Nitrous Oxide	107-112	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	26-29
11818770-1	2002	BACKGROUND: The authors recently established that the analgesic actions of the inhalation anesthetic nitrous oxide were mediated by noradrenergic bulbospinal neurons and spinal alpha2B adrenoceptors.	Nitrous Oxide	101-114	adrenergic receptor, alpha 2b	Mus musculus	177-184
11753029-0	2002	Developmental variation in nitrous oxide-induced c-fos expression in Fischer rat spinal cord.	Nitrous Oxide	27-40	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	49-54
11502893-8	2001	N(2)O selectively blocked currents arising from the Ca(v)3.2 but not Ca(v)3.1 recombinant channels stably expressed in human embryonic kidney (HEK) cells in a concentration-dependent manner with an apparent affinity and potency similar to native dorsal root ganglion currents.	Nitrous Oxide	0-5	immunoglobulin lambda variable 7-43	Homo sapiens	52-60
11506121-6	2001	RESULTS: In Fischer rats, 90 min of 75% N2O administration increased the number of c-Fos-positive cells in the spinal cord approximately threefold as compared with the control group.	Nitrous Oxide	40-43	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	83-88
11506121-7	2001	The c-Fos-positive cells induced by nitrous oxide were almost entirely colocalized with glutamic acid decarboxylase-positive cells.	Nitrous Oxide	36-49	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	4-9
11465552-9	2001	Nitrous oxide (approximately 0.6 atmosphere) slightly but selectively potentiated GIRK channels.	Nitrous Oxide	0-13	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	82-86
11512867-0	2001	Local structure of Pb(II) ion catalysts anchored within zeolite cavities and their photocatalytic reactivity for the elimination of N2O.	Nitrous Oxide	132-135	submaxillary gland androgen regulated protein 3B	Homo sapiens	19-25
11379677-8	2001	RESULTS: The OAA/S score at which only 50% of the volunteers were able to respond to the ART (P50) during propofol-N2O was 11.1 of 20 (95% confidence interval [CI]: 10.6-11.8); the analogous P50 was 11.8 of 20 (95% CI: 11.4-12.3) with propofol-air.	Nitrous Oxide	115-118	nuclear factor kappa B subunit 1	Homo sapiens	94-97
11392474-9	2001	Prevention of breakdown of bradykinin, substance P and neurotensin may result in direct vasodilation or release of nitrous oxide from the endothelium.	Nitrous Oxide	115-128	kininogen 1	Homo sapiens	27-37
11392474-9	2001	Prevention of breakdown of bradykinin, substance P and neurotensin may result in direct vasodilation or release of nitrous oxide from the endothelium.	Nitrous Oxide	115-128	tachykinin precursor 1	Homo sapiens	39-50
11392474-9	2001	Prevention of breakdown of bradykinin, substance P and neurotensin may result in direct vasodilation or release of nitrous oxide from the endothelium.	Nitrous Oxide	115-128	neurotensin	Homo sapiens	55-66
11347911-6	2001	Only traces of RDX were mineralized to CO2 and N2O by the indigenous microorganisms in nonsterile topsoil.	Nitrous Oxide	47-50	radixin	Homo sapiens	15-18
11347911-7	2001	Of the RDX that was mineralized to N2O, one N originated from the ring and the other from the nitro group substituent, as determined using N15 ring-labeled RDX.	Nitrous Oxide	35-38	radixin	Homo sapiens	7-10
11347911-7	2001	Of the RDX that was mineralized to N2O, one N originated from the ring and the other from the nitro group substituent, as determined using N15 ring-labeled RDX.	Nitrous Oxide	35-38	radixin	Homo sapiens	156-159
11347911-8	2001	However, N2O from RDX represented only 3% of the total N2O that formed from the process of nitrification/denitrification.	Nitrous Oxide	9-12	radixin	Homo sapiens	18-21
11347911-8	2001	However, N2O from RDX represented only 3% of the total N2O that formed from the process of nitrification/denitrification.	Nitrous Oxide	55-58	radixin	Homo sapiens	18-21
11159233-0	2001	Xenon inhibits but N(2)O enhances ketamine-induced c-Fos expression in the rat posterior cingulate and retrosplenial cortices.	Nitrous Oxide	19-24	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	51-56
10795767-1	2000	We have previously reported that ingestion of vegetables containing high nitrate (NO3-) increases breath nitrous oxide (N2O) concentration, probably due to denitrification.	Nitrous Oxide	105-118	NBL1, DAN family BMP antagonist	Homo sapiens	82-85
11125002-0	2000	Antinociceptive action of nitrous oxide is mediated by stimulation of noradrenergic neurons in the brainstem and activation of [alpha]2B adrenoceptors.	Nitrous Oxide	26-39	adrenergic receptor, alpha 2b	Mus musculus	128-136
11125002-2	2000	Having established that N(2)O-induced release of norepinephrine mediates the analgesic action at alpha(2) adrenoceptors in the spinal cord, we now investigated whether activation of noradrenergic nuclei in the brainstem is responsible for this analgesic action and which alpha(2) adrenoceptor subtype mediates this property.	Nitrous Oxide	24-29	adrenergic receptor, alpha 2a	Mus musculus	97-119
11125002-2	2000	Having established that N(2)O-induced release of norepinephrine mediates the analgesic action at alpha(2) adrenoceptors in the spinal cord, we now investigated whether activation of noradrenergic nuclei in the brainstem is responsible for this analgesic action and which alpha(2) adrenoceptor subtype mediates this property.	Nitrous Oxide	24-29	adrenergic receptor, alpha 2b	Mus musculus	97-102
11125002-3	2000	In rats, Fos immunoreactivity was examined in brainstem noradrenergic nuclei after exposure to nitrous oxide.	Nitrous Oxide	95-108	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	9-12
11125002-8	2000	Null mice for the alpha(2B) adrenoceptor subtype exhibited a reduced or absent analgesic response to N(2)O, but their sedative response to N(2)O was intact.	Nitrous Oxide	101-106	adrenergic receptor, alpha 2b	Mus musculus	18-40
11125859-10	2000	The degradation of PKC increased significantly after inhalation of N2O.	Nitrous Oxide	67-70	protein kinase C, gamma	Rattus norvegicus	19-22
10895052-5	2000	Dose-response curves constructed from the data indicated that the antinociceptive effect of nitrous oxide was significantly antagonized by antisera to various dynorphins (DYNs) and methionine-enkephalin (ME), but not by antiserum to beta-endorphin (beta-EP).	Nitrous Oxide	92-105	pro-opiomelanocortin-alpha	Mus musculus	233-247
10895052-5	2000	Dose-response curves constructed from the data indicated that the antinociceptive effect of nitrous oxide was significantly antagonized by antisera to various dynorphins (DYNs) and methionine-enkephalin (ME), but not by antiserum to beta-endorphin (beta-EP).	Nitrous Oxide	92-105	pro-opiomelanocortin-alpha	Mus musculus	249-256
11237288-5	2001	More than 94% of the N2O was from the reduction of NO3-, probably due to aerobic nitrate respiration as well as respiratory denitrification.	Nitrous Oxide	21-24	NBL1, DAN family BMP antagonist	Homo sapiens	51-54
11257884-14	2001	Headspace analysis showed production of N2O, suggesting the enrichment coupled the biodegradation of PAH to denitrification.	Nitrous Oxide	40-43	phenylalanine hydroxylase	Homo sapiens	101-104
11117583-5	2000	Breath N2O was significantly correlated with gastric NO3- (P < 0.01) and was higher in patients with elevated gastric NO2- (246 +/- 87 ppb) than in patients without NO2- (75 +/- 13 ppb).	Nitrous Oxide	7-10	NBL1, DAN family BMP antagonist	Homo sapiens	53-56
11117583-7	2000	In conclusion, fasting breath N2O concentration is in some manner related to intragastric NO3- and NO2- concentrations.	Nitrous Oxide	30-33	NBL1, DAN family BMP antagonist	Homo sapiens	90-93
10926225-0	2000	An unsymmetrical tripodal ligand with an N2OS donor set: coordination chemistry with nickel(II)ions and aerial oxidation to the sulfinate complex The synthesis of the previously unknown tripodal ligand H4-1 is reported.	Nitrous Oxide	41-45	CDV3 homolog	Homo sapiens	202-206
10795767-1	2000	We have previously reported that ingestion of vegetables containing high nitrate (NO3-) increases breath nitrous oxide (N2O) concentration, probably due to denitrification.	Nitrous Oxide	120-123	NBL1, DAN family BMP antagonist	Homo sapiens	82-85
10795767-2	2000	In the present study, we estimated NO3- metabolism in the intestine by determining exhaled breath N2O concentration after the ingestion of vegetables by 16 healthy Chinese and Japanese.	Nitrous Oxide	98-101	NBL1, DAN family BMP antagonist	Homo sapiens	35-38
11272537-1	2000	Myoglobin (Mb), in films of dimethyldidodecylammonium bromide (ddab) on graphite electrodes, is used as a catalyst to mediate the electrochemical reduction of nitrous oxide (N2O) as well as the isoelectronic ion azide (N3-) in aqueous solutions.	Nitrous Oxide	159-172	myoglobin	Homo sapiens	0-9
10714665-9	2000	The role of nitrous oxide anesthesia in revealing subclinical B12 deficiency must be emphazised.	Nitrous Oxide	12-25	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	62-65
10672972-4	2000	Nitrous oxide antinociception was significantly attenuated by 24-h pretreatment with antisera to various fragments of dynorphin (DYN) but not by antisera against methionine-enkephalin (ME) or beta-endorphin (beta-EP).	Nitrous Oxide	0-13	pro-opiomelanocortin-alpha	Mus musculus	192-206
10672972-4	2000	Nitrous oxide antinociception was significantly attenuated by 24-h pretreatment with antisera to various fragments of dynorphin (DYN) but not by antisera against methionine-enkephalin (ME) or beta-endorphin (beta-EP).	Nitrous Oxide	0-13	pro-opiomelanocortin-alpha	Mus musculus	208-215
10672972-5	2000	In other experiments, nitrous oxide antinociception was significantly enhanced by 30-min pretreatment with phosphoramidon, an inhibitor of endopeptidase 24.11, which has been implicated in DYN degradation, but not bestatin or captopril, which inhibit aminopeptidase and angiotensin-converting enzyme, respectively.	Nitrous Oxide	22-35	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	270-299
11272537-0	2000	Catalytic two-electron reductions of N2O and N3- by myoglobin in surfactant films.	Nitrous Oxide	37-40	myoglobin	Homo sapiens	52-61
11272537-1	2000	Myoglobin (Mb), in films of dimethyldidodecylammonium bromide (ddab) on graphite electrodes, is used as a catalyst to mediate the electrochemical reduction of nitrous oxide (N2O) as well as the isoelectronic ion azide (N3-) in aqueous solutions.	Nitrous Oxide	159-172	myoglobin	Homo sapiens	11-13
11272537-1	2000	Myoglobin (Mb), in films of dimethyldidodecylammonium bromide (ddab) on graphite electrodes, is used as a catalyst to mediate the electrochemical reduction of nitrous oxide (N2O) as well as the isoelectronic ion azide (N3-) in aqueous solutions.	Nitrous Oxide	174-177	myoglobin	Homo sapiens	0-9
11272537-1	2000	Myoglobin (Mb), in films of dimethyldidodecylammonium bromide (ddab) on graphite electrodes, is used as a catalyst to mediate the electrochemical reduction of nitrous oxide (N2O) as well as the isoelectronic ion azide (N3-) in aqueous solutions.	Nitrous Oxide	174-177	myoglobin	Homo sapiens	11-13
10584542-2	1999	Nitrous oxide may cause neurological and haematological signs and symptoms, as a result of its tendency to form complex with cobalt(I) in methylcobalamin, the cofactor for methionine synthase (EC 2.1.1.13), resulting in irreversible oxidation of the cofactor and inactivation of the enzyme protein.	Nitrous Oxide	0-13	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	172-191
16232852-6	2000	The N2O emission rates in both the aerobic and anoxic phases were significantly influenced by residual NO3-, increasing monotonically as the concentration of NO3- in the reactor increased.	Nitrous Oxide	4-7	NBL1, DAN family BMP antagonist	Homo sapiens	103-106
16232852-6	2000	The N2O emission rates in both the aerobic and anoxic phases were significantly influenced by residual NO3-, increasing monotonically as the concentration of NO3- in the reactor increased.	Nitrous Oxide	4-7	NBL1, DAN family BMP antagonist	Homo sapiens	158-161
18726485-5	1999	On pulse irradiation of nitrous oxide saturated 2 mmol/L dAMP aqueous solution containing verbascoside, the transient absorption spectrum of the hydroxyl adduct of dAMP decayed with the formation of that of the phenoxyl radical of verbascoside well under 100 microseconds after electron pulse irradiation.	Nitrous Oxide	24-37	Amphiphysin	Drosophila melanogaster	57-61
18726485-5	1999	On pulse irradiation of nitrous oxide saturated 2 mmol/L dAMP aqueous solution containing verbascoside, the transient absorption spectrum of the hydroxyl adduct of dAMP decayed with the formation of that of the phenoxyl radical of verbascoside well under 100 microseconds after electron pulse irradiation.	Nitrous Oxide	24-37	Amphiphysin	Drosophila melanogaster	164-168
10584542-5	1999	The risk may be avoided by giving vitamin B12 to patients with confirmed or suspected cobalamin deficiency in good time before surgery involving nitrous oxide anaesthesia.	Nitrous Oxide	145-158	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	42-45
10497264-4	1999	The results show that GST-alpha-hOgg1 protein excises 8-hydroxyguanine (8-OH-Gua) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) from DNA exposed to gamma-irradiation in a solution saturated with N(2)O or air.	Nitrous Oxide	207-212	8-oxoguanine DNA glycosylase	Homo sapiens	32-37
10475306-5	1999	These general features of the dynamic cerebrovascular response were not affected by substitution of N2O for N2 in the inspired gases although N2O increased baseline V(MCA) by 15% (P < 0.001) compared with the control condition.	Nitrous Oxide	142-145	complement C2	Homo sapiens	180-182
9952154-0	1999	Nitrous oxide produces antinociceptive response via alpha2B and/or alpha2C adrenoceptor subtypes in mice.	Nitrous Oxide	0-13	adrenergic receptor, alpha 2c	Mus musculus	67-87
10377254-0	1999	Co-ordinate variations in methylmalonyl-CoA mutase and methionine synthase, and the cobalamin cofactors in human glioma cells during nitrous oxide exposure and the subsequent recovery phase.	Nitrous Oxide	133-146	methylmalonyl-CoA mutase	Homo sapiens	26-50
10377254-0	1999	Co-ordinate variations in methylmalonyl-CoA mutase and methionine synthase, and the cobalamin cofactors in human glioma cells during nitrous oxide exposure and the subsequent recovery phase.	Nitrous Oxide	133-146	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	55-74
10377254-10	1999	Our data demonstrate that the nitrous oxide-induced changes in MS and CH3Cbl are associated with reversible changes in both MCM holoactivity and the AdoCbl level, suggesting co-ordinate distribution of Cbl cofactors during depletion and repletion.	Nitrous Oxide	30-43	methylmalonyl-CoA mutase	Homo sapiens	124-127
10417728-0	1999	Short communication: emission of nitrous oxide (N2O) from transgenic tobacco expressing antisense NiR mRNA The emission of N2 and N2O from intact transgenic tobacco (clone 271) expressing antisense nitrite reductase (NiR) mRNA, and wild-type plants grown aseptically, on NO3-, NO2- or NH4+ -containing medium was investigated.	Nitrous Oxide	33-46	ferredoxin--nitrite reductase, chloroplastic-like	Nicotiana tabacum	98-101
10417728-0	1999	Short communication: emission of nitrous oxide (N2O) from transgenic tobacco expressing antisense NiR mRNA The emission of N2 and N2O from intact transgenic tobacco (clone 271) expressing antisense nitrite reductase (NiR) mRNA, and wild-type plants grown aseptically, on NO3-, NO2- or NH4+ -containing medium was investigated.	Nitrous Oxide	48-51	ferredoxin--nitrite reductase, chloroplastic-like	Nicotiana tabacum	98-101
10417728-0	1999	Short communication: emission of nitrous oxide (N2O) from transgenic tobacco expressing antisense NiR mRNA The emission of N2 and N2O from intact transgenic tobacco (clone 271) expressing antisense nitrite reductase (NiR) mRNA, and wild-type plants grown aseptically, on NO3-, NO2- or NH4+ -containing medium was investigated.	Nitrous Oxide	131-134	ferredoxin--nitrite reductase, chloroplastic-like	Nicotiana tabacum	98-101
9952154-0	1999	Nitrous oxide produces antinociceptive response via alpha2B and/or alpha2C adrenoceptor subtypes in mice.	Nitrous Oxide	0-13	adrenergic receptor, alpha 2b	Mus musculus	52-59
11671052-0	1999	Possible Intermediate Formation of Cyclic Nitrous Oxide, N(2)O: Reaction of Oxygen Difluoride, OF(2), with Cesium Azide, CsN(3).	Nitrous Oxide	57-62	casein kappa	Homo sapiens	121-127
9645277-5	1998	RESULTS: During general anaesthesia with fentanyl, thiopental, isoflurane and nitrous oxide there was a significant decrease of circulating NK cells in the peripheral blood accompanied by a significant increase of B cells and CD8+ T lymphocytes.	Nitrous Oxide	78-91	CD8a molecule	Homo sapiens	226-229
9804904-9	1998	However, the number of PPD mRNA-expressing neurons in both the ketamine and nitrous oxide groups was significantly less than the halothane group.	Nitrous Oxide	76-89	prodynorphin	Rattus norvegicus	23-26
9685364-6	1998	In both cell lines, TCII receptor activity was further increased when growth in homocysteine medium was combined with N2O exposure.	Nitrous Oxide	118-121	transcobalamin 2	Homo sapiens	20-24
9753959-1	1998	In the present study, effects of midazolam, thiopental sodium, propofol, and nitrous oxide upon SEP in a clinically used dose were investigated on 24 male volunteers.	Nitrous Oxide	77-90	plexin B1	Homo sapiens	96-99
9753959-2	1998	In addition, antagonistic actions of flumazenil and naloxone against effects of midazolam and nitrous oxide, respectively, on SEP were studied.	Nitrous Oxide	94-107	plexin B1	Homo sapiens	126-129
9605689-6	1998	RESULTS: Nitrous oxide depresses C5a- or FMLP-induced generation of reactive oxygen derivatives in a concentration-dependent manner.	Nitrous Oxide	9-22	complement C5a receptor 1	Homo sapiens	33-36
9602597-0	1998	Effects of isoflurane-nitrous oxide anaesthesia on insulin secretion in female patients.	Nitrous Oxide	22-35	insulin	Homo sapiens	51-58
9219837-0	1997	Response of the methionine synthase system to short-term culture with homocysteine and nitrous oxide and its relation to methionine dependence.	Nitrous Oxide	87-100	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	16-35
9515109-3	1997	The best known of these is the endothelial factor EDRF identified as nitrous oxide (NO).	Nitrous Oxide	69-82	alpha hemoglobin stabilizing protein	Homo sapiens	50-54
9369046-9	1997	It was concluded in this study that LFA using the FGF of 600 ml.min-1 with setting of 3% sevoflurane, 50% oxygen and nitrous oxide, could be performed safely without risks such as hypoxia and severe delay of induction for patients weighing 53 +/- 5 kg for a duration of 5 hours.	Nitrous Oxide	117-130	CD59 molecule (CD59 blood group)	Homo sapiens	64-69
9278558-0	1997	Compartmentation of folate metabolism in rat pancreas: nitrous oxide inactivation of methionine synthase leads to accumulation of 5-methyltetrahydrofolate in cytosol.	Nitrous Oxide	55-68	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	85-104
9278558-2	1997	Because vitamin B-12 deficiency perturbs folate metabolism, we determined the effects of nitrous oxide inactivation of methionine synthase on the compartmentation of folate metabolism in rat pancreas.	Nitrous Oxide	89-102	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	119-138
9278558-10	1997	The activity of methionine synthase was 85% lower (P < 0.001) in pancreatic extracts of rats exposed to nitrous oxide than in controls.	Nitrous Oxide	107-120	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	16-35
15281315-8	1998	With new technology for cytological screening techniques using dot ELISA and evidence of differences in TP53 mutations that support the involvement of nitrous oxide, it is clear that there is more to learn from study of this tumour type that may be of general interest in understanding the clonal development of cancer.	Nitrous Oxide	151-164	tumor protein p53	Homo sapiens	104-108
9219837-5	1997	Further metabolic differences were induced by N2O exposure, which markedly reduced Met-synthase activity in cell-free extracts in both cell lines and completely blocked intact-cell Hcy remethylation in P60, whereas Hcy remethylation was only partly inhibited in P60H cells cultured in Met medium.	Nitrous Oxide	46-49	interferon induced protein with tetratricopeptide repeats 3	Homo sapiens	202-205
9128034-4	1997	After 15 minutes of high flow anesthesia, the total gas flow was reduced to 300 ml.min-1 of oxygen, 300 ml.min-1 of nitrous oxide or reduced to 400 ml.min-1 of oxygen, 200 ml.min-1 of nitrous oxide in the low flow anesthesia group.	Nitrous Oxide	116-129	CD59 molecule (CD59 blood group)	Homo sapiens	107-112
9100183-5	1997	Mean VMCA increased during normocapnic inhalation of N2O/O2 (tumor side: 86 +/- 16 cm sec-1; healthy side: 74 +/- 17 cm sec-1) when compared with air (tumor side: 72 +/- 18 cm sec-1; healthy side: 62 +/- 14 cm sec-1, p < 0.01), whereas during hyperventilation VMCA decreased on both sides (p < 0.001).	Nitrous Oxide	53-56	secretory blood group 1, pseudogene	Homo sapiens	86-91
16465233-3	1997	Using nitrous oxide to inactivate vitamin B12 we show that, in a variety of cell lines in vitro, methionine synthase is rapidly inhibited, the cells cease proliferation and undergo apoptosis.	Nitrous Oxide	6-19	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	42-45
16465233-3	1997	Using nitrous oxide to inactivate vitamin B12 we show that, in a variety of cell lines in vitro, methionine synthase is rapidly inhibited, the cells cease proliferation and undergo apoptosis.	Nitrous Oxide	6-19	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	97-116
9128034-4	1997	After 15 minutes of high flow anesthesia, the total gas flow was reduced to 300 ml.min-1 of oxygen, 300 ml.min-1 of nitrous oxide or reduced to 400 ml.min-1 of oxygen, 200 ml.min-1 of nitrous oxide in the low flow anesthesia group.	Nitrous Oxide	116-129	CD59 molecule (CD59 blood group)	Homo sapiens	107-112
9128034-4	1997	After 15 minutes of high flow anesthesia, the total gas flow was reduced to 300 ml.min-1 of oxygen, 300 ml.min-1 of nitrous oxide or reduced to 400 ml.min-1 of oxygen, 200 ml.min-1 of nitrous oxide in the low flow anesthesia group.	Nitrous Oxide	116-129	CD59 molecule (CD59 blood group)	Homo sapiens	107-112
9098575-1	1997	The effects of inhalation anesthetics, nitrous oxide (N2O) and halothane, on the expression of c-Fos protein evoked by formalin injection were studied in the spinal cord in the rat.	Nitrous Oxide	39-52	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	95-100
9098575-1	1997	The effects of inhalation anesthetics, nitrous oxide (N2O) and halothane, on the expression of c-Fos protein evoked by formalin injection were studied in the spinal cord in the rat.	Nitrous Oxide	54-57	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	95-100
9098575-8	1997	Both N2O and halothane suppressed the expression of c-Fos in the neck of the dorsal horn and ventral gray in a dose-dependent manner, but no effects were seen at the superficial layer or nucleus proprius.	Nitrous Oxide	5-8	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	52-57
9098575-9	1997	Suppression of c-Fos expression was greater under N2O than halothane anesthesia.	Nitrous Oxide	50-53	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	15-20
8970187-1	1997	In a randomized controlled clinical trial, 14 patients requiring resection of tumors were divided in two groups: one group was anesthetized with nitrous oxide [67% N2O-33% O2 (vol/vol)] and the other with propofol.	Nitrous Oxide	145-158	immunoglobulin kappa variable 1D-39	Homo sapiens	164-174
9023293-10	1997	In the presence of N2O, resting membrane potential was hyperpolarized, a condition that would favor Ca++ efflux mediated by the electrogenic Na+/Ca++ exchanger.	Nitrous Oxide	19-22	solute carrier family 8 member A1	Homo sapiens	141-159
9323446-0	1997	Nitrous oxide attenuates the protective effect of isoflurane on microtubule-associated protein2 degradation during forebrain ischemia in the rat.	Nitrous Oxide	0-13	microtubule-associated protein 2	Rattus norvegicus	64-95
9323446-3	1997	To determine the degree of anesthetic effect on the collapse of cytoskeletal proteins, we compared the effect of three inhalation anesthetics; isoflurane, halothane, and nitrous oxide (N2O), on MAP2 degradation during 20 min of forebrain ischemia in the rat.	Nitrous Oxide	170-183	microtubule-associated protein 2	Rattus norvegicus	194-198
9323446-3	1997	To determine the degree of anesthetic effect on the collapse of cytoskeletal proteins, we compared the effect of three inhalation anesthetics; isoflurane, halothane, and nitrous oxide (N2O), on MAP2 degradation during 20 min of forebrain ischemia in the rat.	Nitrous Oxide	185-188	microtubule-associated protein 2	Rattus norvegicus	194-198
8970187-2	1997	Two other groups of subjects were studied: a group of patients that was undergoing orthopedic procedures and was anesthetized with nitrous oxide [67% N2O-33% O2 (vol/vol)] and a control group (fasted for 10 hrs and no anesthesia).	Nitrous Oxide	131-144	immunoglobulin kappa variable 1D-39	Homo sapiens	150-160
8883887-0	1996	Effect of low and high doses of nitrous oxide on preproenkephalin mRNA and its peptide methionine enkephalin levels in the hypothalamus.	Nitrous Oxide	32-45	proenkephalin	Rattus norvegicus	55-65
11625369-1	1996	Dra, Zimmer describes in this work the evolution of general anaesthesia for surgeries, quoting the recorded invention patents, since the 1st one performed in France - an ether anaesthesia - in 1846, 2 years after Wells had used nitrous oxide as gas for a surgery (december 1844).	Nitrous Oxide	228-241	solute carrier family 26 member 3	Homo sapiens	0-3
8883887-7	1996	Similarly, the concentration of methionine enkephalin was significantly higher after 24 and 48 h of exposure of N2O than after exposure to 12 h of N2O or air.	Nitrous Oxide	112-115	proenkephalin	Rattus norvegicus	43-53
8883887-7	1996	Similarly, the concentration of methionine enkephalin was significantly higher after 24 and 48 h of exposure of N2O than after exposure to 12 h of N2O or air.	Nitrous Oxide	147-150	proenkephalin	Rattus norvegicus	43-53
8883887-8	1996	These results indicate that (a) exposure to N2O results in significant elevations in preproenkephalin mRNA levels, (b) the increased preproenkephalin mRNA levels appear to be proportional to the concentration of N2O exposure as well as the duration of N2O exposure, and (c) N2O-induced elevation in preproenkephalin mRNA levels is associated with corresponding increase in tissue concentrations of methionine enkephalin.	Nitrous Oxide	44-47	proenkephalin	Rattus norvegicus	91-101
8883887-8	1996	These results indicate that (a) exposure to N2O results in significant elevations in preproenkephalin mRNA levels, (b) the increased preproenkephalin mRNA levels appear to be proportional to the concentration of N2O exposure as well as the duration of N2O exposure, and (c) N2O-induced elevation in preproenkephalin mRNA levels is associated with corresponding increase in tissue concentrations of methionine enkephalin.	Nitrous Oxide	212-215	proenkephalin	Rattus norvegicus	91-101
8883887-8	1996	These results indicate that (a) exposure to N2O results in significant elevations in preproenkephalin mRNA levels, (b) the increased preproenkephalin mRNA levels appear to be proportional to the concentration of N2O exposure as well as the duration of N2O exposure, and (c) N2O-induced elevation in preproenkephalin mRNA levels is associated with corresponding increase in tissue concentrations of methionine enkephalin.	Nitrous Oxide	212-215	proenkephalin	Rattus norvegicus	91-101
8883887-8	1996	These results indicate that (a) exposure to N2O results in significant elevations in preproenkephalin mRNA levels, (b) the increased preproenkephalin mRNA levels appear to be proportional to the concentration of N2O exposure as well as the duration of N2O exposure, and (c) N2O-induced elevation in preproenkephalin mRNA levels is associated with corresponding increase in tissue concentrations of methionine enkephalin.	Nitrous Oxide	212-215	proenkephalin	Rattus norvegicus	91-101
8883887-9	1996	In total, these results suggest that N2O selectively stimulates synthesis of methionine enkephalin in the diencephalic region of the brain.	Nitrous Oxide	37-40	proenkephalin	Rattus norvegicus	88-98
7547878-0	1995	Reaction of nitric oxide with the free sulfhydryl group of human serum albumin yields a sulfenic acid and nitrous oxide.	Nitrous Oxide	106-119	albumin	Homo sapiens	65-78
8694299-1	1996	This double-blind study investigates whether isoflurane/N2O anesthesia adds to the bronchodilating effect of the beta 2-adrenergic agonist, fenoterol, after an endotracheal tube (ETT)-induced increase in airway resistance.	Nitrous Oxide	56-59	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	113-119
8613697-5	1996	This IFN-gamma potentiates antigen-presenting cell functions important in clearing infections agents (phagocytosis, oxidative burst, and production of nitrous oxide) and also increases further production of IL-12.	Nitrous Oxide	151-164	interferon gamma	Homo sapiens	5-14
8534966-6	1995	Because N2O inactivates Cbl, abuse of the gas may lead to typical Cbl neuropathy.	Nitrous Oxide	8-11	Cbl proto-oncogene	Homo sapiens	24-27
8534966-6	1995	Because N2O inactivates Cbl, abuse of the gas may lead to typical Cbl neuropathy.	Nitrous Oxide	8-11	Cbl proto-oncogene	Homo sapiens	66-69
7626092-0	1995	Cytochrome c oxidase catalysis of the reduction of nitric oxide to nitrous oxide.	Nitrous Oxide	67-80	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
7545691-3	1995	In the present study, we used a novel nNOS inhibitor, 7-nitroindazole (7-NI) to examine the role of nNOS in CBF during normocapnia and hypercapnia in fentanyl/N2O-anesthetized rats.	Nitrous Oxide	159-162	nitric oxide synthase 1	Rattus norvegicus	100-104
7573909-2	1995	Nitrous oxide (N2O) oxidises vitamin B12 and thus decreases DNA production by inactivation of methionine synthase.	Nitrous Oxide	0-13	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	94-113
7573909-2	1995	Nitrous oxide (N2O) oxidises vitamin B12 and thus decreases DNA production by inactivation of methionine synthase.	Nitrous Oxide	15-18	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	94-113
7626092-1	1995	Reduction of nitric oxide (NO) to nitrous oxide (N2O) is catalyzed by bovine heart cytochrome c oxidase (CcO) in anaerobic solutions at pH 7.2 and 20 degrees C. Cyanide inhibits and forms Fea3(3+)CN.	Nitrous Oxide	34-47	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	83-103
7626092-1	1995	Reduction of nitric oxide (NO) to nitrous oxide (N2O) is catalyzed by bovine heart cytochrome c oxidase (CcO) in anaerobic solutions at pH 7.2 and 20 degrees C. Cyanide inhibits and forms Fea3(3+)CN.	Nitrous Oxide	34-47	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	105-108
7626092-1	1995	Reduction of nitric oxide (NO) to nitrous oxide (N2O) is catalyzed by bovine heart cytochrome c oxidase (CcO) in anaerobic solutions at pH 7.2 and 20 degrees C. Cyanide inhibits and forms Fea3(3+)CN.	Nitrous Oxide	49-52	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	83-103
7626092-1	1995	Reduction of nitric oxide (NO) to nitrous oxide (N2O) is catalyzed by bovine heart cytochrome c oxidase (CcO) in anaerobic solutions at pH 7.2 and 20 degrees C. Cyanide inhibits and forms Fea3(3+)CN.	Nitrous Oxide	49-52	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	105-108
7789050-2	1995	Pigs treated with nitrous oxide for periods of 1, 2 and 4 months demonstrated markedly reduced levels of methionine synthase and concomitant reduction in the ratio of S-adenosylmethionine to S-adenosylhomocysteine, the methylation ratio, at all time intervals.	Nitrous Oxide	18-31	5-methyltetrahydrofolate-homocysteine methyltransferase	Sus scrofa	105-124
28921280-1	1995	The incidence of an abnormal increase in the serum levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) following anesthesia with halothane and 65% nitrous oxide in oxygen (halothane group) or with sevoflurane and 65% nitrous oxide in oxygen (sevoflurane group) was compared in women undergoing surgery for breast cancer.	Nitrous Oxide	185-198	glutamic--pyruvic transaminase	Homo sapiens	136-139
28921280-1	1995	The incidence of an abnormal increase in the serum levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) following anesthesia with halothane and 65% nitrous oxide in oxygen (halothane group) or with sevoflurane and 65% nitrous oxide in oxygen (sevoflurane group) was compared in women undergoing surgery for breast cancer.	Nitrous Oxide	255-268	glutamic--pyruvic transaminase	Homo sapiens	136-139
7789050-9	1995	Rats maintained in nitrous oxide for 4 months showed a marked reduction of methionine synthase but no reduction in the methylation ratio or in brain hypomethylation.	Nitrous Oxide	19-32	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	75-94
7719049-2	1995	Nitrous oxide (N2O) oxidizes vitamin B12 and thus decreases DNA production by inactivation of methionine synthase.	Nitrous Oxide	0-13	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	94-113
7558184-1	1995	Inactivation of methionine synthase (MS) by nitrous oxide (N2O) administration to animals and man has been postulated to be mediated by hydroxyl radical (OH).	Nitrous Oxide	44-57	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	16-35
7558184-1	1995	Inactivation of methionine synthase (MS) by nitrous oxide (N2O) administration to animals and man has been postulated to be mediated by hydroxyl radical (OH).	Nitrous Oxide	59-62	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	16-35
7719049-2	1995	Nitrous oxide (N2O) oxidizes vitamin B12 and thus decreases DNA production by inactivation of methionine synthase.	Nitrous Oxide	15-18	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	94-113
8789622-1	1995	Activity of the vitamin B12-dependent enzyme, methylmalonyl CoA mutase, was measured in the tissues of pigs, fed a diet which was low in cobalt and vitamin B12, and which were intermittently exposed to nitrous oxide until they displayed marked ataxia.	Nitrous Oxide	202-215	methylmalonyl-CoA mutase	Sus scrofa	46-70
8069855-10	1994	The maximal homocysteine export rate in the presence of nitrous oxide, which reflects the overall transmethylation rate, was high in P60 and even higher in P60R compared to the lower passages.	Nitrous Oxide	56-69	interferon induced protein with tetratricopeptide repeats 3	Homo sapiens	133-136
7815708-0	1994	[Changes in plasma concentrations of human hepatocyte growth factor before and after major intra-abdominal surgery under nitrous oxide-sevoflurane anesthesia].	Nitrous Oxide	121-134	hepatocyte growth factor	Homo sapiens	43-67
7929038-1	1994	We report here a comprehensive infrared spectroscopic study of the interactions between the anesthetic nitrous oxide (N2O) and six proteins: lysozyme, cytochrome c, myoglobin, hemoglobin, serum albumin, and cytochrome c oxidase.	Nitrous Oxide	103-116	cytochrome c, somatic	Homo sapiens	151-163
7929038-1	1994	We report here a comprehensive infrared spectroscopic study of the interactions between the anesthetic nitrous oxide (N2O) and six proteins: lysozyme, cytochrome c, myoglobin, hemoglobin, serum albumin, and cytochrome c oxidase.	Nitrous Oxide	103-116	cytochrome c, somatic	Homo sapiens	207-219
7929038-1	1994	We report here a comprehensive infrared spectroscopic study of the interactions between the anesthetic nitrous oxide (N2O) and six proteins: lysozyme, cytochrome c, myoglobin, hemoglobin, serum albumin, and cytochrome c oxidase.	Nitrous Oxide	118-121	cytochrome c, somatic	Homo sapiens	151-163
7929038-1	1994	We report here a comprehensive infrared spectroscopic study of the interactions between the anesthetic nitrous oxide (N2O) and six proteins: lysozyme, cytochrome c, myoglobin, hemoglobin, serum albumin, and cytochrome c oxidase.	Nitrous Oxide	118-121	cytochrome c, somatic	Homo sapiens	207-219
7929038-5	1994	The amount of N2O molecules bound to myoglobin increases as the pH decreases from 9.2 to 5.2.	Nitrous Oxide	14-17	myoglobin	Homo sapiens	37-46
7929038-7	1994	N2O-induced secondary structure changes were detected only in the fully reduced cytochrome c oxidase, not in the fully oxidized oxidase and the other five proteins.	Nitrous Oxide	0-3	cytochrome c, somatic	Homo sapiens	80-92
7821555-0	1994	In vitro NO and N2O inhibition of the branch point enzyme vitamin B12 dependent methionine synthase from rat brain synaptosomes.	Nitrous Oxide	16-19	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	58-99
7967026-6	1994	DRS for the female patients shifted to the left, and the differences between both sexes seemed to decrease in the group receiving nitrous oxide.	Nitrous Oxide	130-143	sushi repeat containing protein X-linked	Homo sapiens	0-3
7831592-8	1994	Finally, while complete agreement among studies is lacking, many have observed an increased risk of subfertility or SAB associated with work in medical occupations and with some specific medical exposures, such as nitrous oxide, anesthetic gases and antineoplastic drugs.	Nitrous Oxide	214-227	SH3 domain binding protein 5	Homo sapiens	116-119
8182526-2	1994	In the mouse abdominal constriction test, pretreatment with the nitric oxide synthase (NOS) inhibitor L-NG-nitroarginine (L-NOARG) caused dose-related antagonism of the antinociceptive effect of N2O but not of either morphine or trans(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl] benzeneacetamide methane sulfonate.	Nitrous Oxide	195-198	nitric oxide synthase 1, neuronal	Mus musculus	64-85
8017644-0	1994	Preoperative methionine loading enhances restoration of the cobalamin-dependent enzyme methionine synthase after nitrous oxide anesthesia.	Nitrous Oxide	113-126	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	87-106
8017644-3	1994	The inactivation of methionine synthase by nitrous oxide in cultured human fibroblasts is decreased at high concentrations of methionine in culture medium.	Nitrous Oxide	43-56	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	20-39
8017644-7	1994	RESULTS: After nitrous oxide exposure, a considerable inactivation of methionine synthase in mononuclear white blood cells was seen in all patients, reaching a nadir after 5-48 h. In the patients not subjected to a methionine load, recovery of enzyme activity was not complete within 7 days.	Nitrous Oxide	15-28	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	70-89
8017644-12	1994	CONCLUSIONS: Our data suggest that short time exposure to nitrous oxide selectively impairs the function of the cobalamin-dependent methionine synthase.	Nitrous Oxide	58-71	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	112-151
7941962-4	1994	MATERIAL AND METHODS: 5-week-old pigs were maintained in an environment of either air or nitrous oxide, which inhibits methionine synthase, and were fed either a methionine-unsupplemented or methionine-enriched diet.	Nitrous Oxide	89-102	5-methyltetrahydrofolate-homocysteine methyltransferase	Sus scrofa	119-138
8142373-0	1994	Nitrous oxide degradation by cobalamin-dependent methionine synthase: characterization of the reactants and products in the inactivation reaction.	Nitrous Oxide	0-13	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	29-68
8170632-0	1994	Vitamin B12 supplements as protection against nitrous oxide inhalation.	Nitrous Oxide	46-59	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
8170632-2	1994	Vitamin B12 supplements can reverse some of the effects of chronic N2O exposure.	Nitrous Oxide	67-70	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
8463342-2	1993	The cytochrome P-450 (P-450) exhibited a potent nitric oxide (NO) reductase activity to form nitrous oxide (N2O) employing NADH but not NADPH as the sole effective electron donor.	Nitrous Oxide	93-106	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	4-20
8134195-1	1994	We investigated the nitrous oxide-induced inactivation of methionine synthase and the concurrent homocysteine (Hcy) export in mutant fibroblasts with defects in the homocysteine catabolizing enzyme, cystathionine beta-synthase, or in methionine synthase, which carries out homocysteine remethylation.	Nitrous Oxide	20-33	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	58-77
8134195-1	1994	We investigated the nitrous oxide-induced inactivation of methionine synthase and the concurrent homocysteine (Hcy) export in mutant fibroblasts with defects in the homocysteine catabolizing enzyme, cystathionine beta-synthase, or in methionine synthase, which carries out homocysteine remethylation.	Nitrous Oxide	20-33	cystathionine beta-synthase	Homo sapiens	199-226
8134195-1	1994	We investigated the nitrous oxide-induced inactivation of methionine synthase and the concurrent homocysteine (Hcy) export in mutant fibroblasts with defects in the homocysteine catabolizing enzyme, cystathionine beta-synthase, or in methionine synthase, which carries out homocysteine remethylation.	Nitrous Oxide	20-33	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	234-253
8134195-10	1994	The low susceptibility of methionine synthase to nitrous oxide in the presence of high methionine or in cb1G or cb1E mutants is probably related to low catalytic turnover.	Nitrous Oxide	49-62	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	26-45
8110542-5	1994	With nitrous oxide, the acute hypoxic response was 10.3 (6.7) litre min-1, but was followed by a nonsignificant decline of 3.8 (3.0) litre min-1 because of a progressive increase in breathing frequency in the hypoxic period.	Nitrous Oxide	5-18	CD59 molecule (CD59 blood group)	Homo sapiens	68-73
7708906-5	1994	For preparations irradiated under N2O, the radiation yield for MetHb formation was three-fold lower in the presence of ethanol and 1-butanol [G(MetHb) = 0.33] compared with preparations irradiated in the presence of t-butanol or without alcohol [G(MetHb) = 1.00].	Nitrous Oxide	34-37	hemoglobin subunit gamma 2	Homo sapiens	63-68
7708906-5	1994	For preparations irradiated under N2O, the radiation yield for MetHb formation was three-fold lower in the presence of ethanol and 1-butanol [G(MetHb) = 0.33] compared with preparations irradiated in the presence of t-butanol or without alcohol [G(MetHb) = 1.00].	Nitrous Oxide	34-37	hemoglobin subunit gamma 2	Homo sapiens	144-149
7708906-5	1994	For preparations irradiated under N2O, the radiation yield for MetHb formation was three-fold lower in the presence of ethanol and 1-butanol [G(MetHb) = 0.33] compared with preparations irradiated in the presence of t-butanol or without alcohol [G(MetHb) = 1.00].	Nitrous Oxide	34-37	hemoglobin subunit gamma 2	Homo sapiens	144-149
8141810-1	1993	DNA single strand breaks were determined in peripheral lymphocytes of neurosurgical patients before and after 180 min of general anesthesia with isoflurane (CAS 26675-46-7)-nitrous oxide-oxygen.	Nitrous Oxide	173-186	BCAR1 scaffold protein, Cas family member	Homo sapiens	157-160
8263793-0	1993	Methionine synthase inactivation by nitrous oxide during methionine loading of normal human fibroblasts.	Nitrous Oxide	36-49	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-19
8263793-2	1993	Nitrous oxide inactivates the enzyme methionine synthase by oxidation of enzyme bound cobalamin, which is formed from the cofactor methylcobalamin during the catalytic cycle.	Nitrous Oxide	0-13	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	37-56
8282644-8	1993	We show that these gas and blood gas N2O relationships give direct derivation of cardiorespiratory parameters such as VA, Qp, the dead space-to-total ventilation ratio (VD/VT), and the shunt-to-total blood flow ratio (Qs/QT) without altering the subject"s oxygenation and that they are essentially free from recirculation effects at high forcing frequencies > or = 2 min-1.	Nitrous Oxide	37-40	CD59 molecule (CD59 blood group)	Homo sapiens	370-375
7691130-2	1993	Exposure to nitrous oxide (N2O) causes inactivation of cobalamin and a subsequent decrease in the vitamin B12-dependent enzymes methionine synthase and methylmalonyl CoA mutase.	Nitrous Oxide	12-25	methylmalonyl-CoA mutase	Rattus norvegicus	152-176
7691130-2	1993	Exposure to nitrous oxide (N2O) causes inactivation of cobalamin and a subsequent decrease in the vitamin B12-dependent enzymes methionine synthase and methylmalonyl CoA mutase.	Nitrous Oxide	27-30	methylmalonyl-CoA mutase	Rattus norvegicus	152-176
8463342-2	1993	The cytochrome P-450 (P-450) exhibited a potent nitric oxide (NO) reductase activity to form nitrous oxide (N2O) employing NADH but not NADPH as the sole effective electron donor.	Nitrous Oxide	108-111	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	4-20
8315800-5	1993	Then the fresh gas flow was reduced to oxygen 250 ml.min-1 and nitrous oxide 250 ml.min-1.	Nitrous Oxide	63-76	CD59 molecule (CD59 blood group)	Homo sapiens	84-89
8315800-6	1993	In order to maintain the inspired oxygen concentration at 35%, the flow of nitrous oxide should have been reduced as low as to 150 ml.min-1 after 240 min.	Nitrous Oxide	75-88	CD59 molecule (CD59 blood group)	Homo sapiens	134-139
8425570-3	1993	The effect of N2O on the behavior of murine colony-forming units-cytokine (CFU-C) in vitro was studied by incubating granulocyte/macrophage colony-stimulating factor (GM-CSF)-stimulated bone marrow cultures for 7 days in an atmosphere of either 5% CO2 in air or 50% N2O/5% CO2 in air.	Nitrous Oxide	14-17	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	117-165
8425570-3	1993	The effect of N2O on the behavior of murine colony-forming units-cytokine (CFU-C) in vitro was studied by incubating granulocyte/macrophage colony-stimulating factor (GM-CSF)-stimulated bone marrow cultures for 7 days in an atmosphere of either 5% CO2 in air or 50% N2O/5% CO2 in air.	Nitrous Oxide	14-17	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	167-173
8425570-5	1993	In contrast, when residual CFU-C numbers were determined in bone marrow liquid cultures after 7 days of incubation in the presence of GM-CSF, exposure to N2O was found to dramatically enhance CFU-C recovery.	Nitrous Oxide	154-157	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	134-140
8433499-7	1993	Addition of nitrous oxide prolonged PEP and PEP/LVET, and shortened Pd/ICT.	Nitrous Oxide	12-25	prolyl endopeptidase	Homo sapiens	36-39
8502112-10	1993	ODC activity was not affected by either treatment in dams but was increased by N2O in embryos.	Nitrous Oxide	79-82	ornithine decarboxylase 1	Homo sapiens	0-3
8433499-7	1993	Addition of nitrous oxide prolonged PEP and PEP/LVET, and shortened Pd/ICT.	Nitrous Oxide	12-25	prolyl endopeptidase	Homo sapiens	44-47
1510550-1	1992	The electrical activity of single units located in the parvicellular part of the red nucleus (pRP) was recorded extracellularly in nitrous oxide anesthetized and C1-transected adult cats.	Nitrous Oxide	131-144	Major prion protein	Felis catus	94-97
1337983-0	1992	Inhibition of plant and animal cytochrome oxidases by nitrous oxide as a function of cytochrome c concentration.	Nitrous Oxide	54-67	LOC104968582	Bos taurus	85-97
1337983-3	1992	These results suggest that the N2O-induced inhibition of cytochrome c oxidase is modulated by cytochrome c concentration.	Nitrous Oxide	31-34	LOC104968582	Bos taurus	57-69
1337983-3	1992	These results suggest that the N2O-induced inhibition of cytochrome c oxidase is modulated by cytochrome c concentration.	Nitrous Oxide	31-34	LOC104968582	Bos taurus	94-106
1417958-1	1992	Using nitrous oxide to inactivate methionine synthase in vivo, the relationship of the activity of methionine synthase to the S-adenosylmethionine (AdoMet)/S-adenosylhomocysteine (AdoHcy) ratio was examined in neural and other tissues of the pig.	Nitrous Oxide	6-19	5-methyltetrahydrofolate-homocysteine methyltransferase	Sus scrofa	34-53
1602376-10	1992	In the responsive murine fibroblasts and the glioma cells, the homocysteine export rate varied inversely to the changes in methionine synthase activity induced by nitrous oxide exposure at different concentrations of folate in the medium.	Nitrous Oxide	163-176	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	123-142
1637609-0	1992	Influence of vitamin B12 status on the inactivation of methionine synthase by nitrous oxide.	Nitrous Oxide	78-91	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	21-24
1637609-0	1992	Influence of vitamin B12 status on the inactivation of methionine synthase by nitrous oxide.	Nitrous Oxide	78-91	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	55-74
1637609-1	1992	We have studied the influence of maternal serum B12 concentration on the inactivation of placental methionine synthase activity by nitrous oxide in an obstetric population.	Nitrous Oxide	131-144	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	48-51
1637609-1	1992	We have studied the influence of maternal serum B12 concentration on the inactivation of placental methionine synthase activity by nitrous oxide in an obstetric population.	Nitrous Oxide	131-144	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	99-118
1637609-4	1992	There was a highly significant relation between placental methionine synthase activity and duration of exposure to nitrous oxide.	Nitrous Oxide	115-128	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	58-77
1637609-7	1992	There was evidence that inactivation by nitrous oxide was more rapid in patients with small concentrations of B12.	Nitrous Oxide	40-53	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	110-113
1637609-8	1992	We conclude that some patients with reduced serum concentrations of B12 may be at a disadvantage with nitrous oxide anaesthesia.	Nitrous Oxide	102-115	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	68-71
1602376-1	1992	Nitrous oxide irreversibly inactivates cob(I)alamin, which serves as a cofactor of the enzyme methionine synthase catalyzing the remethylation of homocysteine to methionine.	Nitrous Oxide	0-13	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	94-113
1602376-11	1992	The enhancement of homocysteine export rate of some cell types during nitrous oxide exposure probably reflects inhibition of homocysteine remethylation in intact cells, and highlights the utility of extracellular homocysteine as an indicator of metabolic flux through the methionine synthase pathway.	Nitrous Oxide	70-83	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	272-291
1583909-7	1992	Exposure to N2O decreased methionine synthase activities in liver, kidney and brain, and recovery of methionine synthase activities occurred over a period of 4 days in both the aged ethanol-fed and control groups.	Nitrous Oxide	12-15	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	26-45
1533464-6	1992	Mianserin, a 5-HT1c/5-HT2 receptor blocker, potentiated effects of both nitrous oxide and U-50,488H but not that of sufentanil.	Nitrous Oxide	72-85	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	13-19
1922806-4	1991	In three patients with neuropsychiatric syndromes due to cobalamin deficiency and one patient with a normal serum cobalamin level who was an abuser of nitrous oxide, CSF concentrations were markedly increased (mean level, 600 times that of controls), out of proportion to those in the serum (mean CSF: serum ratio, 8.38; range, 3.5 to 13.5).	Nitrous Oxide	151-164	colony stimulating factor 2	Homo sapiens	166-169
1354465-4	1992	Data from recently developed animal models of the Cb1 neuropathy induced by exposure to nitrous oxide do not substantiate this hypothesis, but rather identify impairment of the methylcobalamin-dependent methionine synthetase reaction as the more important basic defect.	Nitrous Oxide	88-101	cannabinoid receptor 1	Homo sapiens	50-53
1536404-6	1992	A 90% response to square wave changes of gas composition was maintained up to 60 breaths.min-1 for CO2, O2, and N2O and up to 40 breaths.min-1 for the vapours when the nafion sampling tube was used.	Nitrous Oxide	112-115	CD59 molecule (CD59 blood group)	Homo sapiens	89-94
1726817-0	1991	Effect of nitrous oxide on the concentrations of opioid peptides, substance P, and LHRH in the brain and beta-endorphin in the pituitary.	Nitrous Oxide	10-23	gonadotropin releasing hormone 1	Rattus norvegicus	83-87
1726817-6	1991	Exposure to N2O resulted in significant elevation of LHRH in the preoptic area, with a concomitant decrease in SP.	Nitrous Oxide	12-15	gonadotropin releasing hormone 1	Rattus norvegicus	53-57
1751264-0	1991	Changes in amplitude and latency of the P300 component of the auditory evoked potential with sedative and anaesthetic concentrations of nitrous oxide.	Nitrous Oxide	136-149	E1A binding protein p300	Homo sapiens	40-44
1751264-3	1991	Both the amplitude and the latency of the P300 changed in a dose-dependent manner with nitrous oxide, as did minimum reaction time.	Nitrous Oxide	87-100	E1A binding protein p300	Homo sapiens	42-46
1751264-5	1991	In three subjects, the P300 wave was still detectable with a nitrous oxide concentration at which the task was no longer performed.	Nitrous Oxide	61-74	E1A binding protein p300	Homo sapiens	23-27
1922806-4	1991	In three patients with neuropsychiatric syndromes due to cobalamin deficiency and one patient with a normal serum cobalamin level who was an abuser of nitrous oxide, CSF concentrations were markedly increased (mean level, 600 times that of controls), out of proportion to those in the serum (mean CSF: serum ratio, 8.38; range, 3.5 to 13.5).	Nitrous Oxide	151-164	colony stimulating factor 2	Homo sapiens	297-300
1677545-3	1991	Effective vecuronium infusion requirements averaged 1.5 +/- 0.1 micrograms.kg-1.min-1 (mean +/- SEM) during isoflurane-narcotic-nitrous oxide anesthesia, 1.9 +/- 0.1 micrograms.kg-1.min-1 during halothane-narcotic-nitrous oxide anesthesia, and 2.4 +/- 0.3 micrograms.kg-1.min-1 during narcotic-nitrous oxide anesthesia.	Nitrous Oxide	128-141	CD59 molecule (CD59 blood group)	Homo sapiens	80-85
1767928-0	1991	Nitrous oxide pin indexed conversion program.	Nitrous Oxide	0-13	dynein light chain LC8-type 1	Homo sapiens	14-17
1850410-5	1991	The nitrite reductase activity measured by NO and N2O gas evolution can be restored to 82% of the activity of the original enzyme when the protein was reconstituted with the native heme d1 and to 77% of the activity when reconstituted with the synthetic heme d1.	Nitrous Oxide	50-53	nitrite reductase small subunit NirD	Pseudomonas stutzeri	4-21
1680184-4	1991	With continued exposure to nitrous oxide SAMe concentrations in the two areas returned to nearly normal at 24 h. The observation that levels did not continue to decline, and even returned towards control levels, while animals were still in the presence of the gas suggests that a mechanism other than that of methionine synthase inhibition may have been responsible for the initial effect.	Nitrous Oxide	27-40	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	309-328
2072511-5	1991	3) The levels of serum granulocyte-macrophage colony stimulating factor (CSF) in N2O exposed mice, induced by endotoxin, decreased significantly compared with those of control mice.	Nitrous Oxide	81-84	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	23-71
2033449-4	1991	The effect of isoflurane (superimposed on a baseline of N2O/narcotic anesthesia) on MEP"s in response to cortical stimulation is specifically examined.	Nitrous Oxide	56-59	cathepsin L	Homo sapiens	84-87
1846742-2	1991	Reduction of nitrate, or nitrite, to N2O under aerobic conditions involves NO as an intermediate, as judged by trapping experiments with the ferric form of extracellular horse heart cytochrome c and the demonstration that the cells possess a nitric oxide reductase activity.	Nitrous Oxide	37-40	cytochrome c, somatic	Equus caballus	182-194
2014480-2	1991	These results cast doubt on the commonly held theory that inactivation of methionine synthase is the sole cause of N2O-induced reproductive toxicity, and suggest the need for other hypotheses.	Nitrous Oxide	115-118	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	74-93
1809046-5	1991	Nitrous oxide reacts with the reduced form of vitamin B12, thereby inhibiting the action of methionine synthase, an enzyme that indirectly supports methylation reactions and nucleic acid synthesis.	Nitrous Oxide	0-13	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	92-111
2016907-1	1991	The effects of methotrexate (inhibiting dihydrofolate reductase) and nitrous oxide (inactivating methionine synthase) on intracellular folate coenzyme levels of leukemic cells were studied.	Nitrous Oxide	69-82	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	97-116
1800019-0	1991	Decrease of beta-endorphin in the brain of rats following nitrous oxide withdrawal.	Nitrous Oxide	58-71	proopiomelanocortin	Homo sapiens	12-26
1800019-2	1991	However, a significant decrease of beta-endorphin was found in the whole brain, brain stem and subcortex during the withdrawal from chronic exposure to N2O.	Nitrous Oxide	152-155	proopiomelanocortin	Homo sapiens	35-49
1800019-3	1991	It has been suggested that decrease of beta-endorphin levels during N2O withdrawal could be ascribed to unspecific stress accompanying drug withdrawal.	Nitrous Oxide	68-71	proopiomelanocortin	Homo sapiens	39-53
1800019-4	1991	Decrease of central beta-endorphin during N2O withdrawal might have a significant modulatory effect on transmitter balance, neuronal excitability and corresponding withdrawal behaviour.	Nitrous Oxide	42-45	proopiomelanocortin	Homo sapiens	20-34
1800019-5	1991	Furthermore, the decrease of beta-endorphin levels in the whole brain during N2O withdrawal might contribute to the postanaesthesia N2O-excitatory syndrome in humans.	Nitrous Oxide	77-80	proopiomelanocortin	Homo sapiens	29-43
1800019-5	1991	Furthermore, the decrease of beta-endorphin levels in the whole brain during N2O withdrawal might contribute to the postanaesthesia N2O-excitatory syndrome in humans.	Nitrous Oxide	132-135	proopiomelanocortin	Homo sapiens	29-43
2240633-1	1990	Exposure to nitrous oxide (N2O) markedly enhances excretion of formic acid and formiminoglutamic acid (FIGLU) in the urine of rats, suggesting a disruption in the normal pathways of folic acid metabolism secondary to an N2O-induced inactivation of methionine synthase.	Nitrous Oxide	12-25	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	248-267
2240633-1	1990	Exposure to nitrous oxide (N2O) markedly enhances excretion of formic acid and formiminoglutamic acid (FIGLU) in the urine of rats, suggesting a disruption in the normal pathways of folic acid metabolism secondary to an N2O-induced inactivation of methionine synthase.	Nitrous Oxide	27-30	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	248-267
2289052-1	1990	Concentrations in pig tissues after inactivation of methionine synthase by nitrous oxide.	Nitrous Oxide	75-88	5-methyltetrahydrofolate-homocysteine methyltransferase	Sus scrofa	52-71
2289052-6	1990	The method was used to assess changes in AdoMet and AdoHcy concentrations of pig tissues after seven days exposure to the anaesthetic gas nitrous oxide which irreversibly inactivates methionine synthase and induces an inability to recycle homocysteine, particularly in neural tissues.	Nitrous Oxide	138-151	5-methyltetrahydrofolate-homocysteine methyltransferase	Sus scrofa	183-202
2287636-6	1990	On going from argon to N2O saturation, phi ssb and phi dsb become larger by factors of approximately 5 and 10-15, respectively.	Nitrous Oxide	23-26	small RNA binding exonuclease protection factor La	Bos taurus	43-46
2248850-2	1990	Nitrous oxide significantly increased CD50 from 46.8 (1.4) mg kg-1 of control to 57.3 (1.3) mg kg-1 at 20 min and 53.5 (1.7) mg kg-1 at 180 min.	Nitrous Oxide	0-13	intercellular adhesion molecule 5, telencephalin	Mus musculus	38-42
2096739-1	1990	Our laboratory has reported changes in luteinizing hormone releasing hormone (LHRH) from the hypothalamus following nitrous oxide (N2O) exposure.	Nitrous Oxide	116-129	gonadotropin releasing hormone 1	Rattus norvegicus	39-76
2393136-8	1990	Hepatic methionine synthase activities (measured 16-21 days after N2O exposure) were elevated in the elderly compared to the middle-aged or young rats, but methionine synthase activities in kidney and brain were not different among the three different age groups.	Nitrous Oxide	66-69	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	8-27
2208532-2	1990	In comparison with baseline measurements, nitrous oxide administration resulted in small but statistically significant (P less than 0.05) changes in mean arterial pressure (76 +/- 14 to 67 +/- 12), mean pulmonary arterial pressure (37 +/- 14 to 33 +/- 13 mmHg), and cardiac output (3.7 +/- 1.4 to 3.2 +/- 1.1 L.min-1).	Nitrous Oxide	42-55	CD59 molecule (CD59 blood group)	Homo sapiens	311-316
2096739-1	1990	Our laboratory has reported changes in luteinizing hormone releasing hormone (LHRH) from the hypothalamus following nitrous oxide (N2O) exposure.	Nitrous Oxide	131-134	gonadotropin releasing hormone 1	Rattus norvegicus	78-82
2096739-1	1990	Our laboratory has reported changes in luteinizing hormone releasing hormone (LHRH) from the hypothalamus following nitrous oxide (N2O) exposure.	Nitrous Oxide	116-129	gonadotropin releasing hormone 1	Rattus norvegicus	78-82
2096739-12	1990	A threefold increase in LHRH cells was noted in N2O rats.	Nitrous Oxide	48-51	gonadotropin releasing hormone 1	Rattus norvegicus	24-28
2141969-10	1990	In summary, pseudocholinesterase activity is the major factor influencing mivacurium infusion rate in children during nitrous oxide-narcotic or nitrous oxide-halothane (0.8% end-tidal) anesthesia.	Nitrous Oxide	118-131	butyrylcholinesterase	Homo sapiens	12-32
2141969-10	1990	In summary, pseudocholinesterase activity is the major factor influencing mivacurium infusion rate in children during nitrous oxide-narcotic or nitrous oxide-halothane (0.8% end-tidal) anesthesia.	Nitrous Oxide	144-157	butyrylcholinesterase	Homo sapiens	12-32
2096739-16	1990	The constant proestrus seen after N2O exposure is due to disruption of LHRH cells in the hypothalamus (blocked LHRH release).	Nitrous Oxide	34-37	gonadotropin releasing hormone 1	Rattus norvegicus	71-75
2096739-1	1990	Our laboratory has reported changes in luteinizing hormone releasing hormone (LHRH) from the hypothalamus following nitrous oxide (N2O) exposure.	Nitrous Oxide	131-134	gonadotropin releasing hormone 1	Rattus norvegicus	39-76
2096739-16	1990	The constant proestrus seen after N2O exposure is due to disruption of LHRH cells in the hypothalamus (blocked LHRH release).	Nitrous Oxide	34-37	gonadotropin releasing hormone 1	Rattus norvegicus	111-115
33970624-1	2021	Using UV-vis and resonance Raman spectroscopy, we identify a [Cu2O]2+ active site in O2 and N2O activated Cu-CHA that reacts with methane to form methanol at low temperature.	Nitrous Oxide	92-95	transcription factor like 5	Homo sapiens	109-112
2407589-2	1990	Insufficient availability of cobalamin, or inhibition of methionine synthase by exposure to nitrous oxide, leads to diminished activity of this enzyme.	Nitrous Oxide	92-105	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	57-76
2107864-4	1990	These higher methionine synthase activities in the DMTU-treated animals represented a delay in the enzyme inactivation produced by nitrous oxide, as the difference in activities between the DMTU-injected and saline-injected mice decreased with increasing duration of exposure to nitrous oxide.	Nitrous Oxide	131-144	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	13-32
2107864-4	1990	These higher methionine synthase activities in the DMTU-treated animals represented a delay in the enzyme inactivation produced by nitrous oxide, as the difference in activities between the DMTU-injected and saline-injected mice decreased with increasing duration of exposure to nitrous oxide.	Nitrous Oxide	279-292	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	13-32
2107864-7	1990	DMTU exhibited its greatest effect in the kidney, where methionine synthase activities were nearly doubled in the DMTU 2.0 mg g-1-injected compared with the saline-injected mice after 1-h exposure to 66% nitrous oxide.	Nitrous Oxide	204-217	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	56-75
2189194-1	1990	The administration of nitrous oxide rapidly inactivates the vitamin B12-dependent enzyme methionine synthase.	Nitrous Oxide	22-35	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	89-108
2360736-5	1990	Isoflurane administration both with and without nitrous oxide led to a decrease of MSA (P less than 0.05).	Nitrous Oxide	48-61	thyroid peroxidase	Homo sapiens	83-86
2360736-6	1990	However, during nitrous oxide/isoflurane anesthesia (1.0 MAC) MSA was 76 +/- 38% higher than when isoflurane was used alone, although this implied a decrease in anesthetic depth to 0.5 MAC.	Nitrous Oxide	16-29	thyroid peroxidase	Homo sapiens	62-65
2107864-0	1990	Dimethylthiourea, a hydroxyl radical scavenger, impedes the inactivation of methionine synthase by nitrous oxide in mice.	Nitrous Oxide	99-112	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	76-95
2107864-1	1990	Dimethylthiourea (DMTU), a potent scavenger of hydroxyl radicals, was studied to see if it attenuated the inactivation of methionine synthase produced by nitrous oxide in mice.	Nitrous Oxide	154-167	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	122-141
1980440-2	1990	Vitamin B12 deficiency induced in the fruit bat by a combination of dietary deprivation and exposure to nitrous oxide (N2O) is accompanied by profound neurological impairment, thus providing an experimental model for the study of vitamin B12 neuropathy.	Nitrous Oxide	104-117	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
1980440-2	1990	Vitamin B12 deficiency induced in the fruit bat by a combination of dietary deprivation and exposure to nitrous oxide (N2O) is accompanied by profound neurological impairment, thus providing an experimental model for the study of vitamin B12 neuropathy.	Nitrous Oxide	119-122	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
33973360-0	2021	Rapid-acting antidepressants and the regulation of TrkB neurotrophic signalling - insights from ketamine, nitrous oxide, seizures, and anaesthesia.	Nitrous Oxide	106-119	neurotrophic receptor tyrosine kinase 2	Homo sapiens	51-55
33973360-5	2021	We have shown nitrous oxide to evoke TrkB signalling preferentially after the acute pharmacological effects have dissipated (i.e. after receptor disengagement), when slow delta-frequency electroencephalogram (EEG) activity is upregulated.	Nitrous Oxide	14-27	neurotrophic receptor tyrosine kinase 2	Homo sapiens	37-41
7988578-3	1994	Nitrous oxide administration for 5 min caused a decrease in mean arterial pressure from 82 +/- 10 to 71 +/- 12.7 mmHg (P < 0.001), cardiac index (2.8 +/- 0.5 to 2.4 +/- 0.5 litres min-1 m-2, P < 0.01), heart rate (104 +/- 17 to 99 +/- 18 beats min-1, P < 0.05), left ventricular stroke work index (29.4 +/- 8.1 to 22 +/- 8.7 gm-m beat-1 mm-1, P < 0.001), stroke volume (45.3 +/- 11.6 to 40 +/- 12.8 ml beat-1, P < 0.05) and an increase in pulmonary vascular resistance from 106.4 +/- 53.9 to 143.9 +/- 81.0 dynes s cm-5 (P < 0.01) and right atrial pressure (1.42 +/- 2.09 to 1.71 +/- 2.21 mmHg, P < 0.05).	Nitrous Oxide	0-13	CD59 molecule (CD59 blood group)	Homo sapiens	183-188
33590530-3	2021	Nitrous oxide irreversibly binds and inactivates vitamin B12, which is an important co-factor in metabolic pathways involved in DNA and myelin synthesis.	Nitrous Oxide	0-13	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	57-60
7988578-3	1994	Nitrous oxide administration for 5 min caused a decrease in mean arterial pressure from 82 +/- 10 to 71 +/- 12.7 mmHg (P < 0.001), cardiac index (2.8 +/- 0.5 to 2.4 +/- 0.5 litres min-1 m-2, P < 0.01), heart rate (104 +/- 17 to 99 +/- 18 beats min-1, P < 0.05), left ventricular stroke work index (29.4 +/- 8.1 to 22 +/- 8.7 gm-m beat-1 mm-1, P < 0.001), stroke volume (45.3 +/- 11.6 to 40 +/- 12.8 ml beat-1, P < 0.05) and an increase in pulmonary vascular resistance from 106.4 +/- 53.9 to 143.9 +/- 81.0 dynes s cm-5 (P < 0.01) and right atrial pressure (1.42 +/- 2.09 to 1.71 +/- 2.21 mmHg, P < 0.05).	Nitrous Oxide	0-13	CD59 molecule (CD59 blood group)	Homo sapiens	250-255
34921878-6	2022	Moreover, reclaiming riverside wetland as farmland will increase CO2 and N2O emission fluxes by 54.546-72.684 t ha-1 and 2.615-2.988 kg ha-1, respectively.	Nitrous Oxide	73-76	Rho GTPase activating protein 45	Homo sapiens	112-122
34914357-6	2022	In addition, in situ differential electrochemical mass spectrometry (DEMS) indicated that ultrafast *NO2- to *NO reduction and highly selective *NO to *N2O or *N transformation played crucial roles during the NO3- reduction process.	Nitrous Oxide	152-155	NBL1, DAN family BMP antagonist	Homo sapiens	209-212
34921878-6	2022	Moreover, reclaiming riverside wetland as farmland will increase CO2 and N2O emission fluxes by 54.546-72.684 t ha-1 and 2.615-2.988 kg ha-1, respectively.	Nitrous Oxide	73-76	Rho GTPase activating protein 45	Homo sapiens	136-140
34909324-4	2021	We highlight a case of subacute combined degeneration in a young patient secondary to recreational nitrous oxide use, which improved with vitamin B12 replacement.	Nitrous Oxide	99-112	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	146-149
34438167-6	2021	Annual cumulative emissions for all urban turfgrasses ranged from 0.75 to 1.27 kg N ha-1 yr-1 for N2O and from 0.30 to 0.46 kg N ha-1 yr-1 for NO, both are generally higher than those of Chinese natural grasslands.	Nitrous Oxide	98-101	solute carrier family 9 member B1	Homo sapiens	82-93
34298361-6	2021	The results showed a nonlinear response of N2O fluxes to liming rates, with highest fluxes at the intermediate liming level (4 Mg ha-1).	Nitrous Oxide	43-46	Rho GTPase activating protein 45	Homo sapiens	130-134
34348577-0	2021	Activation of NLR family, domain of pyrin containing 3 inflammasome by nitrous oxide through thioredoxin-interacting protein to induce nerve cell injury.	Nitrous Oxide	71-84	Mediterranean fever	Mus musculus	36-41
34348577-2	2021	The purpose of this work is to probe into the impact of N2O on nerve cell injury through regulating thioredoxin-interacting protein (TXNIP)/the NOD-like receptor domain of pyrin containing 3 (NLRP3) pathway.	Nitrous Oxide	56-59	thioredoxin interacting protein	Mus musculus	133-138
34348577-2	2021	The purpose of this work is to probe into the impact of N2O on nerve cell injury through regulating thioredoxin-interacting protein (TXNIP)/the NOD-like receptor domain of pyrin containing 3 (NLRP3) pathway.	Nitrous Oxide	56-59	NLR family, pyrin domain containing 3	Mus musculus	192-197
34348577-3	2021	The results indicated that, N2O exposure elevated TXNIP/NLRP3 expression in vivo and in vitro, led to declined learning and memory capabilities in mice, reduced apoptosis rate in hippocampal neuron and Nissl bodies, elevated inflammatory factors TNF-alpha, IL-1beta and IL-6 levels, as well as cleaved caspase-3 and Bax expressions, and reduced Bcl-2 expression.	Nitrous Oxide	28-31	thioredoxin interacting protein	Mus musculus	50-55
34348577-3	2021	The results indicated that, N2O exposure elevated TXNIP/NLRP3 expression in vivo and in vitro, led to declined learning and memory capabilities in mice, reduced apoptosis rate in hippocampal neuron and Nissl bodies, elevated inflammatory factors TNF-alpha, IL-1beta and IL-6 levels, as well as cleaved caspase-3 and Bax expressions, and reduced Bcl-2 expression.	Nitrous Oxide	28-31	NLR family, pyrin domain containing 3	Mus musculus	56-61
34348577-3	2021	The results indicated that, N2O exposure elevated TXNIP/NLRP3 expression in vivo and in vitro, led to declined learning and memory capabilities in mice, reduced apoptosis rate in hippocampal neuron and Nissl bodies, elevated inflammatory factors TNF-alpha, IL-1beta and IL-6 levels, as well as cleaved caspase-3 and Bax expressions, and reduced Bcl-2 expression.	Nitrous Oxide	28-31	tumor necrosis factor	Mus musculus	246-255
34348577-3	2021	The results indicated that, N2O exposure elevated TXNIP/NLRP3 expression in vivo and in vitro, led to declined learning and memory capabilities in mice, reduced apoptosis rate in hippocampal neuron and Nissl bodies, elevated inflammatory factors TNF-alpha, IL-1beta and IL-6 levels, as well as cleaved caspase-3 and Bax expressions, and reduced Bcl-2 expression.	Nitrous Oxide	28-31	interleukin 1 alpha	Mus musculus	257-265
34348577-3	2021	The results indicated that, N2O exposure elevated TXNIP/NLRP3 expression in vivo and in vitro, led to declined learning and memory capabilities in mice, reduced apoptosis rate in hippocampal neuron and Nissl bodies, elevated inflammatory factors TNF-alpha, IL-1beta and IL-6 levels, as well as cleaved caspase-3 and Bax expressions, and reduced Bcl-2 expression.	Nitrous Oxide	28-31	interleukin 6	Mus musculus	270-274
34348577-3	2021	The results indicated that, N2O exposure elevated TXNIP/NLRP3 expression in vivo and in vitro, led to declined learning and memory capabilities in mice, reduced apoptosis rate in hippocampal neuron and Nissl bodies, elevated inflammatory factors TNF-alpha, IL-1beta and IL-6 levels, as well as cleaved caspase-3 and Bax expressions, and reduced Bcl-2 expression.	Nitrous Oxide	28-31	caspase 3	Mus musculus	302-311
34348577-3	2021	The results indicated that, N2O exposure elevated TXNIP/NLRP3 expression in vivo and in vitro, led to declined learning and memory capabilities in mice, reduced apoptosis rate in hippocampal neuron and Nissl bodies, elevated inflammatory factors TNF-alpha, IL-1beta and IL-6 levels, as well as cleaved caspase-3 and Bax expressions, and reduced Bcl-2 expression.	Nitrous Oxide	28-31	BCL2-associated X protein	Mus musculus	316-319
34348577-3	2021	The results indicated that, N2O exposure elevated TXNIP/NLRP3 expression in vivo and in vitro, led to declined learning and memory capabilities in mice, reduced apoptosis rate in hippocampal neuron and Nissl bodies, elevated inflammatory factors TNF-alpha, IL-1beta and IL-6 levels, as well as cleaved caspase-3 and Bax expressions, and reduced Bcl-2 expression.	Nitrous Oxide	28-31	B cell leukemia/lymphoma 2	Mus musculus	345-350
34348577-6	2021	All in all, the results manifested that N2O is available to promote nerve cell inflammation and apoptosis through activating the TXNIP/NLRP3 pathway that can be used as a potential target for N2O-induced nerve damage in the future.	Nitrous Oxide	40-43	thioredoxin interacting protein	Mus musculus	129-134
34348577-6	2021	All in all, the results manifested that N2O is available to promote nerve cell inflammation and apoptosis through activating the TXNIP/NLRP3 pathway that can be used as a potential target for N2O-induced nerve damage in the future.	Nitrous Oxide	40-43	NLR family, pyrin domain containing 3	Mus musculus	135-140
34348577-6	2021	All in all, the results manifested that N2O is available to promote nerve cell inflammation and apoptosis through activating the TXNIP/NLRP3 pathway that can be used as a potential target for N2O-induced nerve damage in the future.	Nitrous Oxide	192-195	thioredoxin interacting protein	Mus musculus	129-134
34348577-6	2021	All in all, the results manifested that N2O is available to promote nerve cell inflammation and apoptosis through activating the TXNIP/NLRP3 pathway that can be used as a potential target for N2O-induced nerve damage in the future.	Nitrous Oxide	192-195	NLR family, pyrin domain containing 3	Mus musculus	135-140
34225116-8	2021	Nitrite addition also stimulated nitrous oxide emissions yielded by biotic or chemical processes during STL addition, especially under the transient condition at 50 C-55  C, and resulted in a 28%-39% increase in greenhouse gas emissions compared with that of the control group.	Nitrous Oxide	33-46	RNF217 antisense RNA 1 (head to head)	Homo sapiens	104-107
34315054-5	2021	The direct N2O emissions from fertilizers and residues were 4.43-4.51 t CO2-eq ha-1 yr-1 during the wheat and maize seasons, and indirect N2O emissions from irrigation and fertilizer inputs had a proportion of >80% from total agricultural inputs.	Nitrous Oxide	11-14	1,4-alpha-glucan-branching enzyme 2, chloroplastic/amyloplastic	Zea mays	79-88
34800446-0	2022	Regional distribution and environmental regulation mechanism of nitrous oxide in the Bohai Sea and North Yellow Sea: A preliminary study.	Nitrous Oxide	64-77	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	91-94
34800446-0	2022	Regional distribution and environmental regulation mechanism of nitrous oxide in the Bohai Sea and North Yellow Sea: A preliminary study.	Nitrous Oxide	64-77	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	112-115
34800446-2	2022	In 2019, we conducted three cruises to study the spatial and temporal variability of N2O distribution and emissions in the Bohai Sea (BS) and North Yellow Sea (NYS), and analyzed the regional sources and sinks.	Nitrous Oxide	85-88	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	129-132
34800446-4	2022	The N2O concentration decreased in a gradient from the estuary to the continental shelf, particularly in summer, which indicated that the riverine input from the estuary was a strong source of N2O in the Bohai Sea.	Nitrous Oxide	4-7	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	210-213
34800446-4	2022	The N2O concentration decreased in a gradient from the estuary to the continental shelf, particularly in summer, which indicated that the riverine input from the estuary was a strong source of N2O in the Bohai Sea.	Nitrous Oxide	193-196	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	210-213
34909324-12	2021	The mechanism of subacute combined degeneration in the setting of nitrous oxide toxicity appears to be mediated by functional B12 deficiency.	Nitrous Oxide	66-79	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	126-129
34909324-13	2021	Oxidation of cobalt ion of vitamin B12 by nitrous oxide renders it unavailable as a coenzyme, leading to the accumulation of by-products that enter lipid metabolism, resulting in abnormal myelin synthesis, which ultimately manifests as subacute combined degeneration.	Nitrous Oxide	42-55	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	35-38
34348072-0	2021	Does vitamin B12 deficiency explain psychiatric symptoms in recreational nitrous oxide users?	Nitrous Oxide	73-86	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	13-16
34348072-4	2021	Vitamin B12 deficiency may play a role in the development of these psychiatric symptoms.Aims To explore the relationship among the occurrence of recreational nitrous oxide-induced psychiatric symptoms, accompanying neurological symptoms, vitamin B12 status and choice of treatment.Methods A retrospective search for case reports was conducted across multiple databases (Pubmed, Embase, Web of Science, PsycINFO and CINAHL).	Nitrous Oxide	158-171	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
34348072-4	2021	Vitamin B12 deficiency may play a role in the development of these psychiatric symptoms.Aims To explore the relationship among the occurrence of recreational nitrous oxide-induced psychiatric symptoms, accompanying neurological symptoms, vitamin B12 status and choice of treatment.Methods A retrospective search for case reports was conducted across multiple databases (Pubmed, Embase, Web of Science, PsycINFO and CINAHL).	Nitrous Oxide	158-171	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	246-249
34348072-9	2021	When neurological symptoms were present, patients were treated more frequently with vitamin B12 supplementation.Conclusions This review highlights the need to recognize that psychiatric symptoms may appear in association with nitrous oxide use.	Nitrous Oxide	226-239	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	92-95
34348072-10	2021	Approximately half of the cases that presented with nitrous oxide-induced psychiatric complaints did not show neurological symptoms, and their vitamin B12 concentration was often within the hospital"s reference range.	Nitrous Oxide	52-65	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	151-154
34139563-3	2021	The total N2O emissions ofC and B1C treatments declined by 5.1% and 3.7% while B1, B2, and B2C treatments increased the total N2O emissions by 6.7%, 21.6%, and 10.4%, respectively.	Nitrous Oxide	126-129	membrane spanning 4-domains A1	Homo sapiens	79-85
34786239-0	2021	Myelopathy Secondary to Vitamin B12 Deficiency Induced by Nitrous Oxide Abuse.	Nitrous Oxide	58-71	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	32-35
34786239-1	2021	Nitrous oxide (N2O), a colorless gas known to have abuse potential, can induce vitamin B12 deficiency that eventually leads to peripheral neuropathy, central nervous demyelination, and myelopathy.	Nitrous Oxide	0-13	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	87-90
34786239-1	2021	Nitrous oxide (N2O), a colorless gas known to have abuse potential, can induce vitamin B12 deficiency that eventually leads to peripheral neuropathy, central nervous demyelination, and myelopathy.	Nitrous Oxide	15-18	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	87-90
34786239-4	2021	We outline a case of a patient presenting with acute onset of numbness who was ultimately diagnosed with myelopathy secondary to vitamin B12 deficiency induced by nitrous oxide abuse.	Nitrous Oxide	163-176	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	137-140
34464676-3	2021	Our recent studies suggest that a single subanesthetic dose of NMDAR antagonists ketamine or nitrous oxide (N2O) gradually evoke 1-4 Hz electrophysiological activity (delta-rhythm) of cerebral cortex that is accompanied by molecular signaling associated with synaptic plasticity (e.g. activation of tropomyosin receptor kinase B (TrkB) and inhibition of glycogen synthase kinase 3beta (GSK3beta)).	Nitrous Oxide	93-106	neurotrophic receptor tyrosine kinase 2	Homo sapiens	299-328
34464676-3	2021	Our recent studies suggest that a single subanesthetic dose of NMDAR antagonists ketamine or nitrous oxide (N2O) gradually evoke 1-4 Hz electrophysiological activity (delta-rhythm) of cerebral cortex that is accompanied by molecular signaling associated with synaptic plasticity (e.g. activation of tropomyosin receptor kinase B (TrkB) and inhibition of glycogen synthase kinase 3beta (GSK3beta)).	Nitrous Oxide	93-106	neurotrophic receptor tyrosine kinase 2	Homo sapiens	330-334
34464676-3	2021	Our recent studies suggest that a single subanesthetic dose of NMDAR antagonists ketamine or nitrous oxide (N2O) gradually evoke 1-4 Hz electrophysiological activity (delta-rhythm) of cerebral cortex that is accompanied by molecular signaling associated with synaptic plasticity (e.g. activation of tropomyosin receptor kinase B (TrkB) and inhibition of glycogen synthase kinase 3beta (GSK3beta)).	Nitrous Oxide	93-106	glycogen synthase kinase 3 beta	Homo sapiens	354-384
34464676-3	2021	Our recent studies suggest that a single subanesthetic dose of NMDAR antagonists ketamine or nitrous oxide (N2O) gradually evoke 1-4 Hz electrophysiological activity (delta-rhythm) of cerebral cortex that is accompanied by molecular signaling associated with synaptic plasticity (e.g. activation of tropomyosin receptor kinase B (TrkB) and inhibition of glycogen synthase kinase 3beta (GSK3beta)).	Nitrous Oxide	93-106	glycogen synthase kinase 3 alpha	Homo sapiens	386-394
34464676-3	2021	Our recent studies suggest that a single subanesthetic dose of NMDAR antagonists ketamine or nitrous oxide (N2O) gradually evoke 1-4 Hz electrophysiological activity (delta-rhythm) of cerebral cortex that is accompanied by molecular signaling associated with synaptic plasticity (e.g. activation of tropomyosin receptor kinase B (TrkB) and inhibition of glycogen synthase kinase 3beta (GSK3beta)).	Nitrous Oxide	108-111	neurotrophic receptor tyrosine kinase 2	Homo sapiens	299-328
34464676-3	2021	Our recent studies suggest that a single subanesthetic dose of NMDAR antagonists ketamine or nitrous oxide (N2O) gradually evoke 1-4 Hz electrophysiological activity (delta-rhythm) of cerebral cortex that is accompanied by molecular signaling associated with synaptic plasticity (e.g. activation of tropomyosin receptor kinase B (TrkB) and inhibition of glycogen synthase kinase 3beta (GSK3beta)).	Nitrous Oxide	108-111	neurotrophic receptor tyrosine kinase 2	Homo sapiens	330-334
34464676-3	2021	Our recent studies suggest that a single subanesthetic dose of NMDAR antagonists ketamine or nitrous oxide (N2O) gradually evoke 1-4 Hz electrophysiological activity (delta-rhythm) of cerebral cortex that is accompanied by molecular signaling associated with synaptic plasticity (e.g. activation of tropomyosin receptor kinase B (TrkB) and inhibition of glycogen synthase kinase 3beta (GSK3beta)).	Nitrous Oxide	108-111	glycogen synthase kinase 3 beta	Homo sapiens	354-384
34464676-3	2021	Our recent studies suggest that a single subanesthetic dose of NMDAR antagonists ketamine or nitrous oxide (N2O) gradually evoke 1-4 Hz electrophysiological activity (delta-rhythm) of cerebral cortex that is accompanied by molecular signaling associated with synaptic plasticity (e.g. activation of tropomyosin receptor kinase B (TrkB) and inhibition of glycogen synthase kinase 3beta (GSK3beta)).	Nitrous Oxide	108-111	glycogen synthase kinase 3 alpha	Homo sapiens	386-394
34718979-4	2022	Results showed that compared with CF treatment, both CHF1 and CHF2 treatments increased the N2O + NO emissions by 11.8% and 32.4% on average, while decreased the vegetable yields by 6.7% and 7.4%, respectively.	Nitrous Oxide	92-95	hes related family bHLH transcription factor with YRPW motif 2	Homo sapiens	53-57
34718979-4	2022	Results showed that compared with CF treatment, both CHF1 and CHF2 treatments increased the N2O + NO emissions by 11.8% and 32.4% on average, while decreased the vegetable yields by 6.7% and 7.4%, respectively.	Nitrous Oxide	92-95	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	62-66
34323905-2	2021	Density functional theory suggests that N2O can anchor to Co+ of (Co(N2O)(H2O)n)+ through either O end-on (eta1-OL) or N end-on (eta1-NL) coordinate mode.	Nitrous Oxide	40-43	secreted phosphoprotein 1	Homo sapiens	107-111
34466287-10	2021	The greatest N2O emissions and CH4 sink were recorded under the highest rate of N fertilization (100 kg N ha-1).	Nitrous Oxide	13-16	plasma membrane ATPase	Triticum aestivum	106-110
34466287-16	2021	The practice of applying biochar with N fertilizer at 100 kg ha-1 N resulted in increases in crop productivity and reduced N2O and CH4soil emissions under dryland cropping systems.	Nitrous Oxide	123-126	plasma membrane ATPase	Triticum aestivum	61-65
34098458-2	2021	A plot-based field study was performed in 2017 and 2018 in a cotton field in arid northwestern China, with an objective to elucidate the impact of the applications of conventional urea (Urea), polymer-coated urea (ESN) and stabilized urea (SuperU) at rates of 120 and 240 kg N ha-1 on concentration and efflux of N2O in the soil profile and its relationship with N2O surface emissions.	Nitrous Oxide	313-316	solute carrier family 9 member B1	Homo sapiens	275-281
34514258-5	2021	It has been found that CNT@PDA-Ni complexes have catalytic effects on the decomposition of epsilon-CL-20 by decreasing/shifting of the exothermic peak from T p = 240.1 to 238.7  C. The FT-IR spectra of CL-20 decomposition products under the effect of the catalyst predominantly show peaks at 1274, 1644 and 1596, 1912, 2265, and 1956-1800 cm-1, indicating the presence of fragments with N2O, NO2, NO, HNCO, and NO/CO, respectively.	Nitrous Oxide	387-390	epithelial membrane protein 1	Homo sapiens	202-207
34323905-6	2021	From eta1-O, subsequent N-O bond dissociation to liberate N2, producing (CoO(H2O)n)+, is straightforward via a mechanism that is commonplace for typical metal-catalyzed N2O decompositions.	Nitrous Oxide	169-172	secreted phosphoprotein 1	Homo sapiens	5-9
34323905-2	2021	Density functional theory suggests that N2O can anchor to Co+ of (Co(N2O)(H2O)n)+ through either O end-on (eta1-OL) or N end-on (eta1-NL) coordinate mode.	Nitrous Oxide	40-43	secreted phosphoprotein 1	Homo sapiens	129-133
34323905-5	2021	The initial activation of N2O through an electron transfer from Co+ to N2O yields anionic N2O-, which binds to the metal center of (Co2+(N2O-)(H2O)n) also through either O end-on (eta1-O) or N end-on (eta1-N) mode and is stabilized by water molecules through hydrogen bonding.	Nitrous Oxide	26-29	secreted phosphoprotein 1	Homo sapiens	180-184
34323905-5	2021	The initial activation of N2O through an electron transfer from Co+ to N2O yields anionic N2O-, which binds to the metal center of (Co2+(N2O-)(H2O)n) also through either O end-on (eta1-O) or N end-on (eta1-N) mode and is stabilized by water molecules through hydrogen bonding.	Nitrous Oxide	26-29	secreted phosphoprotein 1	Homo sapiens	201-205
34323905-5	2021	The initial activation of N2O through an electron transfer from Co+ to N2O yields anionic N2O-, which binds to the metal center of (Co2+(N2O-)(H2O)n) also through either O end-on (eta1-O) or N end-on (eta1-N) mode and is stabilized by water molecules through hydrogen bonding.	Nitrous Oxide	71-74	secreted phosphoprotein 1	Homo sapiens	180-184
34323905-5	2021	The initial activation of N2O through an electron transfer from Co+ to N2O yields anionic N2O-, which binds to the metal center of (Co2+(N2O-)(H2O)n) also through either O end-on (eta1-O) or N end-on (eta1-N) mode and is stabilized by water molecules through hydrogen bonding.	Nitrous Oxide	71-74	secreted phosphoprotein 1	Homo sapiens	201-205
34323905-5	2021	The initial activation of N2O through an electron transfer from Co+ to N2O yields anionic N2O-, which binds to the metal center of (Co2+(N2O-)(H2O)n) also through either O end-on (eta1-O) or N end-on (eta1-N) mode and is stabilized by water molecules through hydrogen bonding.	Nitrous Oxide	90-93	secreted phosphoprotein 1	Homo sapiens	180-184
34376630-0	2021	A 19-Year-Old Man with a History of Recreational Inhalation of Nitrous Oxide with Severe Peripheral Neuropathy and Central Pulmonary Embolism.	Nitrous Oxide	63-76	immunoglobulin kappa variable 2-28	Homo sapiens	0-4
34323905-5	2021	The initial activation of N2O through an electron transfer from Co+ to N2O yields anionic N2O-, which binds to the metal center of (Co2+(N2O-)(H2O)n) also through either O end-on (eta1-O) or N end-on (eta1-N) mode and is stabilized by water molecules through hydrogen bonding.	Nitrous Oxide	90-93	secreted phosphoprotein 1	Homo sapiens	201-205
34376630-3	2021	CASE REPORT We report a case of a 19-year-old previously healthy man with occasional recreational use of nitrous oxide of up to 10 times within recent months, who presented with severe peripheral neuropathy.	Nitrous Oxide	105-118	immunoglobulin kappa variable 2-28	Homo sapiens	32-36
34323905-5	2021	The initial activation of N2O through an electron transfer from Co+ to N2O yields anionic N2O-, which binds to the metal center of (Co2+(N2O-)(H2O)n) also through either O end-on (eta1-O) or N end-on (eta1-N) mode and is stabilized by water molecules through hydrogen bonding.	Nitrous Oxide	137-142	secreted phosphoprotein 1	Homo sapiens	180-184
34323905-5	2021	The initial activation of N2O through an electron transfer from Co+ to N2O yields anionic N2O-, which binds to the metal center of (Co2+(N2O-)(H2O)n) also through either O end-on (eta1-O) or N end-on (eta1-N) mode and is stabilized by water molecules through hydrogen bonding.	Nitrous Oxide	137-142	secreted phosphoprotein 1	Homo sapiens	201-205
35077795-3	2022	The results showed that the average hourly N2O emissions during the fallow season were in the order SR (7.4 mug N m-2 h-1), GM (10.7 mug N m-2 h-1), SR + GM (11.7 mug N m-2 h-1), FM (15.5 mug N m-2 h-1), and CK (16.4 mug N m-2 h-1).	Nitrous Oxide	43-46	cytidine/uridine monophosphate kinase 1	Homo sapiens	208-210
34134658-1	2021	BACKGROUND: Megaloblastic anemia or bone marrow changes could occur after prolonged nitrous oxide inhalation via vitamin B12 inactivation related DNA synthesis impairment.	Nitrous Oxide	84-97	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	121-124
35439713-12	2022	Nitrous oxide given during labor is proposed as a contributing risk factor to the development of early infant vitamin B12 deficiency.	Nitrous Oxide	0-13	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	118-121
34207586-3	2021	We conducted across-sectional study that enrolled patients with nitrous oxide toxicity admitted to Vietnam Poison Control Center, Bach Mai Hospital, Hanoi, Vietnam from June 2018 to July 2019.	Nitrous Oxide	64-77	acyl-CoA thioesterase 7	Homo sapiens	130-134
35525502-6	2022	Results revealed that 60% N2O induced CPP in the gas-administered mice and promoted the ERK phosphorylation (p-ERK) in the NAc and CPu during the test session of the CPP test.	Nitrous Oxide	26-29	mitogen-activated protein kinase 1	Mus musculus	88-91
35525502-6	2022	Results revealed that 60% N2O induced CPP in the gas-administered mice and promoted the ERK phosphorylation (p-ERK) in the NAc and CPu during the test session of the CPP test.	Nitrous Oxide	26-29	mitogen-activated protein kinase 1	Mus musculus	111-114
35525502-8	2022	It suggested that Dopamine D1 receptor may play an important role in the acquisition of N2O-induced CPP and the accompanied ERK activation in the NAc, which provide insight into the molecular mechanism in the rewarding properties of nitrous oxide.	Nitrous Oxide	88-91	dopamine receptor D1	Mus musculus	18-38
35525502-8	2022	It suggested that Dopamine D1 receptor may play an important role in the acquisition of N2O-induced CPP and the accompanied ERK activation in the NAc, which provide insight into the molecular mechanism in the rewarding properties of nitrous oxide.	Nitrous Oxide	88-91	mitogen-activated protein kinase 1	Mus musculus	124-127
35525502-8	2022	It suggested that Dopamine D1 receptor may play an important role in the acquisition of N2O-induced CPP and the accompanied ERK activation in the NAc, which provide insight into the molecular mechanism in the rewarding properties of nitrous oxide.	Nitrous Oxide	233-246	dopamine receptor D1	Mus musculus	18-38
35525502-8	2022	It suggested that Dopamine D1 receptor may play an important role in the acquisition of N2O-induced CPP and the accompanied ERK activation in the NAc, which provide insight into the molecular mechanism in the rewarding properties of nitrous oxide.	Nitrous Oxide	233-246	mitogen-activated protein kinase 1	Mus musculus	124-127
35630742-6	2022	The insertion of H2O2, H2O, N2O, and CO2 had significant influence on the electrostatic potential (ESP), van der Waals (vdW) potential and chemical bonding of CL-20.	Nitrous Oxide	28-31	epithelial membrane protein 1	Homo sapiens	159-164
35156819-2	2022	Quantum calculations at the UCCSD(T)/CBS(T, Q, 5)//CCSD/aug-cc-pVTZ level have located two crossing points, MSX1 and MSX2, with energies of 11.2 and 22.7 kcal mol-1 above O(3P) + N2O, respectively.	Nitrous Oxide	179-182	msh homeobox 1	Homo sapiens	108-112
35236032-3	2022	Both BC1 and BC2 reduced N2O total emissions by 62.9-71.9% and 48.8-52.0% in CP-fumigated soil, respectively.	Nitrous Oxide	25-28	charged multivesicular body protein 2A	Homo sapiens	13-16
35236032-4	2022	During the 7-day fumigation phase, however, both BC1 and BC2 increased N2O production by significantly promoting nirKS and norBC gene abundance, which indicated that the N2O emission pathway had switched from heterotrophic denitrification to nitrifier denitrification.	Nitrous Oxide	71-74	charged multivesicular body protein 2A	Homo sapiens	57-60
35236032-4	2022	During the 7-day fumigation phase, however, both BC1 and BC2 increased N2O production by significantly promoting nirKS and norBC gene abundance, which indicated that the N2O emission pathway had switched from heterotrophic denitrification to nitrifier denitrification.	Nitrous Oxide	170-173	charged multivesicular body protein 2A	Homo sapiens	57-60
35236032-5	2022	During the post-fumigation phase, BC1 and BC2 significantly decreased N2O production as insufficient nitrogen was available to support rapid population increases of nitrifying or denitrifying bacteria.	Nitrous Oxide	70-73	charged multivesicular body protein 2A	Homo sapiens	42-45
35013954-9	2022	The nosZ gene, which converts nitrous oxide to nitrogen, was found only in T. Network analysis suggested that the average number of neighbours in T was 3.30% higher than that in CK and the characteristic path length in T was 14.15% higher than that in CK.	Nitrous Oxide	30-43	cytidine/uridine monophosphate kinase 1	Homo sapiens	178-180
35416037-0	2022	Cryptic Sulfur and Oxygen Cycling Potentially Reduces N2O-Driven Greenhouse Warming: Underlying Revision Need of the Nitrogen Cycle.	Nitrous Oxide	54-57	cripto, FRL-1, cryptic family 1	Homo sapiens	0-7
35339580-6	2022	(4) Oil-coated fertilizers can reduce the loss of N by slowing down the hydrolysis rate of urea and the nitrification from NH4+ to NO3-, which reduces the N2O release by 70-80% compared to the uncoated fertilizers.	Nitrous Oxide	155-158	NBL1, DAN family BMP antagonist	Homo sapiens	131-134
35445300-7	2022	The results showed that the N2O emissions ranged from - 35.75 to 74.16 mug m-2 h-1 with 0.89 to 1.44 kg ha-1 being released into the atmosphere during the nongrowing season in the permafrost region.	Nitrous Oxide	28-31	Rho GTPase activating protein 45	Homo sapiens	104-108
35445300-12	2022	In contrast, the N2O emissions from the growing season were controlled by soil temperature, water table level, pH, NH4+-N, NO3--N, total nitrogen, total organic carbon, and C/N ratio, which could explain 14.51-45.72% of the temporal variation of N2O emissions.	Nitrous Oxide	17-20	phenylalanine hydroxylase	Homo sapiens	111-113
35258231-7	2022	The average N2O flux, the total N2O emissions, and the global warming potential of N2O were 1.92-22.75 mug (m2 h)-1, 0.10-0.46 kg hm-2, and 26.72-122.15 kg hm-2, respectively.	Nitrous Oxide	83-86	cholinergic receptor muscarinic 2	Homo sapiens	130-134
35258231-7	2022	The average N2O flux, the total N2O emissions, and the global warming potential of N2O were 1.92-22.75 mug (m2 h)-1, 0.10-0.46 kg hm-2, and 26.72-122.15 kg hm-2, respectively.	Nitrous Oxide	83-86	cholinergic receptor muscarinic 2	Homo sapiens	156-160
35156819-2	2022	Quantum calculations at the UCCSD(T)/CBS(T, Q, 5)//CCSD/aug-cc-pVTZ level have located two crossing points, MSX1 and MSX2, with energies of 11.2 and 22.7 kcal mol-1 above O(3P) + N2O, respectively.	Nitrous Oxide	179-182	msh homeobox 2	Homo sapiens	117-121
35103219-0	2022	Functional Vitamin B12 Deficiency in Association With Nitrous Oxide Inhalation.	Nitrous Oxide	54-67	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	19-22
35112835-5	2022	A coupled heat transfer and gas transport model is developed to investigate emissions of tetrachloroethylene (PCE) and N2O, a typical manufactured volatile organic chemical and a natural gas, from groundwater with seasonally fluctuating GSTs.	Nitrous Oxide	119-122	hematopoietic prostaglandin D synthase	Homo sapiens	237-241
35005959-5	2022	In this study we generalize the interactions of plasmons with molecules by considering the N2O asymmetric stretch SEIRA signal on a Dy doped CdO (CdO:Dy) film.	Nitrous Oxide	91-94	cell adhesion associated, oncogene regulated	Homo sapiens	141-144
35005959-5	2022	In this study we generalize the interactions of plasmons with molecules by considering the N2O asymmetric stretch SEIRA signal on a Dy doped CdO (CdO:Dy) film.	Nitrous Oxide	91-94	cell adhesion associated, oncogene regulated	Homo sapiens	146-149
15815293-0	1989	Nitrous oxide decreases substance P receptor binding in the rat spinal cord.	Nitrous Oxide	0-13	tachykinin receptor 1	Rattus norvegicus	24-44
2764573-7	1989	With nitrous oxide as the respiratory substrate, nitrite reductase was again the most sensitive to oxygen concentration; however, thresholds for all denitrification enzymes shifted to lower oxygen levels.	Nitrous Oxide	5-18	nitrite reductase small subunit NirD	Pseudomonas stutzeri	49-66
2804978-3	1989	This phenomenon may be attributed to the synergistic effects of nitrous oxide, which inactivates the cobalamin coenzyme of methionine synthase, and MTX, which inhibits dihydrofolate reductase, on folate metabolism.	Nitrous Oxide	64-77	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	123-142
2792963-4	1989	In the N2O group, rCBF in both the cerebral cortex and hippocampus decreased significantly to less than 10% of the pre-ischemic value during ischemia, and it increased to 170% at 10 min after reperfusion.	Nitrous Oxide	7-10	CCAAT/enhancer binding protein zeta	Rattus norvegicus	18-22
2919224-3	1989	Spectra of deoxyHb samples irradiated under various conditions (the atmosphere of argon or N2O in the absence or presence of ethanol) indicate their conversion into methemoglobin (metHb), hemichrome- and cholehemichrome-like products.	Nitrous Oxide	91-94	hemoglobin subunit gamma 2	Homo sapiens	165-178
15815248-1	1989	The effect of nitrous oxide (N2O) on somatosensory evoked potentials from the cortical (CEP) and spinal cord (SCP) regions in response to forepaw stimulation was studied in ketamine-anesthetized and mechanically ventilated rats.	Nitrous Oxide	14-27	cysteine-rich secretory protein 3	Rattus norvegicus	110-113
15815248-4	1989	The N13-P21 component of the CEP, the slow positive wave (P2) of the segmental SCP, and the heterosegmental positive cord dorsum potential (HSP) were significantly suppressed by N2O, while the large negative (N1) component of the segmental SCP remained unchanged.	Nitrous Oxide	178-181	cysteine-rich secretory protein 3	Rattus norvegicus	79-82
15815248-4	1989	The N13-P21 component of the CEP, the slow positive wave (P2) of the segmental SCP, and the heterosegmental positive cord dorsum potential (HSP) were significantly suppressed by N2O, while the large negative (N1) component of the segmental SCP remained unchanged.	Nitrous Oxide	178-181	cysteine-rich secretory protein 3	Rattus norvegicus	240-243
2638155-4	1989	SHRs exposed to nitrogen did not exhibit any significant change in SBP or HR, but SHRs exposed to nitrous oxide exhibited a generally concentration-related reduction in both SBP and HR.	Nitrous Oxide	98-111	spermine binding protein	Rattus norvegicus	174-177
2638155-5	1989	WKYs, however, displayed reductions in SBP and HR when exposed to either nitrous oxide or nitrogen.	Nitrous Oxide	73-86	spermine binding protein	Rattus norvegicus	39-42
2753341-0	1989	The inhibitory effects of nitrous oxide and methylmercury in vivo on methionine synthase (EC 2.1.1.13) activity in the brain, liver, ovary and spinal cord of the rat.	Nitrous Oxide	26-39	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	69-88
2753341-4	1989	Exposure (1 hr) of female rats to 50% nitrous oxide (N2O) caused significant decreases in MS in brain, liver, and spinal cord and a sharp drop in ovary.	Nitrous Oxide	38-51	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	90-92
2753341-4	1989	Exposure (1 hr) of female rats to 50% nitrous oxide (N2O) caused significant decreases in MS in brain, liver, and spinal cord and a sharp drop in ovary.	Nitrous Oxide	53-56	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	90-92
2753341-8	1989	Results from a combined treatment with MM and N2O suggests additive inhibition of MS by these agents.	Nitrous Oxide	46-49	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	82-84
2706023-0	1989	Methionine synthase activities in mice following acute exposures to ethanol and nitrous oxide.	Nitrous Oxide	80-93	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	0-19
2706023-1	1989	Acute or chronic exposure to nitrous oxide or chronic exposure to ethanol decreases the activity of the vitamin B12-dependent enzyme methionine synthase.	Nitrous Oxide	29-42	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	133-152
2706023-3	1989	Methionine synthase activities in liver, kidney, and brain were measured immediately after exposure to nitrous oxide and at various times over a 4-day recovery period.	Nitrous Oxide	103-116	5-methyltetrahydrofolate-homocysteine methyltransferase	Mus musculus	0-19
15815236-8	1989	Regional values of the ratio of rCBF/rCMRglc indicated that during hypocapnia and hypotension induced by isoflurane in nitrous oxide/oxygen, the individual brain areas were perfused according to their metabolic needs.	Nitrous Oxide	119-132	CCAAT/enhancer binding protein zeta	Rattus norvegicus	32-36
3341574-0	1988	Rate of inactivation of human and rodent hepatic methionine synthase by nitrous oxide.	Nitrous Oxide	72-85	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	49-68
2511690-7	1989	The real clinical importance of nitrates became, however, evident only in the last decade with the discovery of EDRF, the so-called endothelial-derived relaxing factor, an endogenous compound of endothelial origin at least partly consisting of nitrous oxide and therefore, like nitrates, it exerts its effect through the stimulation of cGMP.	Nitrous Oxide	244-257	alpha hemoglobin stabilizing protein	Homo sapiens	112-116
3264158-0	1988	Nitrous oxide exposure reduces hepatic C1-tetrahydrofolate synthase expression in rats.	Nitrous Oxide	0-13	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Rattus norvegicus	39-67
3204709-0	1988	[An autopsy case of the lethal anesthetic accident caused by nitrous oxide mis-inhalation].	Nitrous Oxide	61-74	anti-Mullerian hormone	Homo sapiens	75-78
3264158-3	1988	Liver tissue from rats exposed to N2O for 48 hours exhibited a coordinate decrease in all three activities of C1-THF synthase of approximately 25%.	Nitrous Oxide	34-37	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Rattus norvegicus	110-125
3264158-6	1988	These results suggest that perturbations of hepatic THF pools by N2O affect the level of C1-THF synthase expression at a translational or pretranslational level.	Nitrous Oxide	65-68	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Rattus norvegicus	89-104
2837481-0	1988	Interactions of the anesthetic nitrous oxide with bovine heart cytochrome c oxidase.	Nitrous Oxide	31-44	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	63-83
2837481-7	1988	N2O appears to affect oxidase activity by reducing the rate of electron transfer from cytochrome c to the O2 reaction site rather than by interfering directly with the reduction of O2 to water.	Nitrous Oxide	0-3	LOC104968582	Bos taurus	86-98
2837481-8	1988	Cytochrome c oxidase represents a target site for nitrous oxide and possibly other anesthetics, and the inhibition of oxidase activity may contribute significantly to the anesthetic and/or toxic effects of these substances.	Nitrous Oxide	50-63	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
16347651-0	1988	Sub-Parts-Per-Billion Nitrate Method: Use of an N(2)O-Producing Denitrifier to Convert NO(3) or NO(3) to N(2)O.	Nitrous Oxide	48-53	NBL1, DAN family BMP antagonist	Homo sapiens	87-92
16347651-0	1988	Sub-Parts-Per-Billion Nitrate Method: Use of an N(2)O-Producing Denitrifier to Convert NO(3) or NO(3) to N(2)O.	Nitrous Oxide	48-53	NBL1, DAN family BMP antagonist	Homo sapiens	96-101
16347651-0	1988	Sub-Parts-Per-Billion Nitrate Method: Use of an N(2)O-Producing Denitrifier to Convert NO(3) or NO(3) to N(2)O.	Nitrous Oxide	105-110	NBL1, DAN family BMP antagonist	Homo sapiens	87-92
16347651-0	1988	Sub-Parts-Per-Billion Nitrate Method: Use of an N(2)O-Producing Denitrifier to Convert NO(3) or NO(3) to N(2)O.	Nitrous Oxide	105-110	NBL1, DAN family BMP antagonist	Homo sapiens	96-101
16347651-3	1988	The selected denitrifier quantitatively converted NO(3) to N(2)O within 10 min.	Nitrous Oxide	59-64	NBL1, DAN family BMP antagonist	Homo sapiens	50-55
16347651-10	1988	Analysis of N(2)O production by use of a progress curve yielded K(m) values of 1.7 and 1.8 muM NO(3) for the two denitrifier strains studied.	Nitrous Oxide	12-17	latexin	Homo sapiens	91-94
16347651-10	1988	Analysis of N(2)O production by use of a progress curve yielded K(m) values of 1.7 and 1.8 muM NO(3) for the two denitrifier strains studied.	Nitrous Oxide	12-17	NBL1, DAN family BMP antagonist	Homo sapiens	95-100
3364667-8	1988	After reduction to MAC 0.5 steady-state, anesthesia was supplemented with 53% N2O to give a steady state of MAC 1.0 again.	Nitrous Oxide	78-81	integrin subunit alpha M	Homo sapiens	108-113
3341574-1	1988	The rate of inactivation of hepatic methionine synthase by nitrous oxide has been determined in 22 patients undergoing laparotomy during general anesthesia, including 70% nitrous oxide.	Nitrous Oxide	59-72	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	36-55
3341574-1	1988	The rate of inactivation of hepatic methionine synthase by nitrous oxide has been determined in 22 patients undergoing laparotomy during general anesthesia, including 70% nitrous oxide.	Nitrous Oxide	171-184	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	36-55
3341574-4	1988	Inactivation of methionine synthase is very much more rapid in the rat exposed to 50% nitrous oxide, with a half-time of 5.4 min.	Nitrous Oxide	86-99	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	16-35
3034260-1	1987	Nitrous oxide affects dioxygen utilization by both bean seed and bovine heart submitochondrial particles when either succinate or reduced cytochrome c are used as substrates.	Nitrous Oxide	0-13	LOC104968582	Bos taurus	138-150
2446836-0	1988	The effects of nitrous oxide on P300 and reaction time.	Nitrous Oxide	15-28	E1A binding protein p300	Homo sapiens	32-36
2446836-4	1988	Nitrous oxide increased both RT and P300 latency in a dose-related manner and these variables showed a strong between-dose correlation (r = 0.67).	Nitrous Oxide	0-13	E1A binding protein p300	Homo sapiens	36-40
2446836-5	1988	Nitrous oxide also decreased P300 amplitude but only up to the 25% dose.	Nitrous Oxide	0-13	E1A binding protein p300	Homo sapiens	29-33
2446836-7	1988	These results suggest that P300 latency is an index of N2O narcosis and are interpreted as indicating that narcosis involves the slowing of stimulus evaluation processes.	Nitrous Oxide	55-58	E1A binding protein p300	Homo sapiens	27-31
3122602-8	1988	These results suggest that pulmonary vascular effects of nitrous oxide depend on preexisting pulmonary vascular tone, and may be modulated by cyclooxygenase products of arachidonic acid metabolism.	Nitrous Oxide	57-70	prostaglandin-endoperoxide synthase 1	Canis lupus familiaris	142-156
3337795-4	1988	Choice reaction time, ability to tap two areas on a board and ability to perform mathematical problems were significantly impaired when inhaling nitrous oxide, the maximum effect being obtained within 5 min.	Nitrous Oxide	145-158	nuclear RNA export factor 1	Homo sapiens	33-36
3335122-0	1988	The P-300 event-related potential in experimental nitrous oxide exposure.	Nitrous Oxide	50-63	E1A binding protein p300	Homo sapiens	4-9
3335122-3	1988	With increasing concentration of N2O, there was prolongation of P-300 latency and worsening of Continuous Performance Test and Symbol Digit Test performance; P-300 amplitude and Finger Tapping Test performance were decreased by exposure to N2O.	Nitrous Oxide	33-36	E1A binding protein p300	Homo sapiens	64-69
3335122-3	1988	With increasing concentration of N2O, there was prolongation of P-300 latency and worsening of Continuous Performance Test and Symbol Digit Test performance; P-300 amplitude and Finger Tapping Test performance were decreased by exposure to N2O.	Nitrous Oxide	33-36	E1A binding protein p300	Homo sapiens	158-163
3335122-3	1988	With increasing concentration of N2O, there was prolongation of P-300 latency and worsening of Continuous Performance Test and Symbol Digit Test performance; P-300 amplitude and Finger Tapping Test performance were decreased by exposure to N2O.	Nitrous Oxide	240-243	E1A binding protein p300	Homo sapiens	64-69
3335122-3	1988	With increasing concentration of N2O, there was prolongation of P-300 latency and worsening of Continuous Performance Test and Symbol Digit Test performance; P-300 amplitude and Finger Tapping Test performance were decreased by exposure to N2O.	Nitrous Oxide	240-243	E1A binding protein p300	Homo sapiens	158-163
3335122-4	1988	This study demonstrates a dose-dependent reduction in P-300 amplitude and prolongation of P-300 latency in subjects in whom psychomotor impairment was induced by the acute administration of N2O.	Nitrous Oxide	190-193	E1A binding protein p300	Homo sapiens	54-59
3335122-4	1988	This study demonstrates a dose-dependent reduction in P-300 amplitude and prolongation of P-300 latency in subjects in whom psychomotor impairment was induced by the acute administration of N2O.	Nitrous Oxide	190-193	E1A binding protein p300	Homo sapiens	90-95
2963838-11	1987	Beta-endorphin levels fell to a greater extent during the inhalation of nitrous oxide than during the control period (51% versus 26%; P less than .05).	Nitrous Oxide	72-85	proopiomelanocortin	Homo sapiens	0-14
2445432-0	1987	The effects of nitrous oxide on the secretory activity of pro-opiomelanocortin peptides from basal hypothalamic cells attached to cytodex beads in a superfusion in vitro system.	Nitrous Oxide	15-28	proopiomelanocortin	Rattus norvegicus	58-78
2445432-6	1987	The increase in beta-endorphin secretory activity during exposure to nitrous oxide demonstrates that nitrous oxide may have a stimulatory effect on central pro-opiomelanocortin neurons.	Nitrous Oxide	69-82	proopiomelanocortin	Rattus norvegicus	156-176
2445432-6	1987	The increase in beta-endorphin secretory activity during exposure to nitrous oxide demonstrates that nitrous oxide may have a stimulatory effect on central pro-opiomelanocortin neurons.	Nitrous Oxide	101-114	proopiomelanocortin	Rattus norvegicus	156-176
2823975-0	1987	The effects of nitrous oxide on the central endogenous pro-opiomelanocortin system in the rat.	Nitrous Oxide	15-28	proopiomelanocortin	Rattus norvegicus	55-75
2823975-1	1987	The hypothesis that nitrous oxide stimulates the central pro-opiomelanocortin system in vivo was explored in this study.	Nitrous Oxide	20-33	proopiomelanocortin	Rattus norvegicus	57-77
2823975-2	1987	A concentration-dependent stimulation of central pro-opiomelanocortin neuropeptides was demonstrated after exposures to variable concentrations of nitrous oxide with oxygen.	Nitrous Oxide	147-160	proopiomelanocortin	Rattus norvegicus	49-69
2823975-6	1987	In conclusion, the increase in beta-endorphin concentration and immunoreactive ACTH1-39 staining in the cells of origin, areas of fiber projection and terminal fields suggest that nitrous oxide stimulates the central pro-opiomelanocortin system in vivo in the rat.	Nitrous Oxide	180-193	proopiomelanocortin	Rattus norvegicus	217-237
3651273-0	1987	Inhibition of rat fetal methionine synthase by nitrous oxide.	Nitrous Oxide	47-60	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	24-43
3651273-2	1987	The effect of in vitro exposure to nitrous oxide on rat fetal and maternal methionine synthase activity was investigated.	Nitrous Oxide	35-48	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	75-94
3548788-0	1987	Clinical aspects of the interaction between nitrous oxide and vitamin B12.	Nitrous Oxide	44-57	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	70-73
2882183-3	1987	The concentration of GST was significantly increased after anaesthesia in patients who received halothane in 30% oxygen/70% nitrous oxide (n = 37) and in patients who received halothane in 100% oxygen (n = 17).	Nitrous Oxide	124-137	glutathione S-transferase kappa 1	Homo sapiens	21-24
3813080-4	1987	Our data confirm the observation that N2O causes a small elevation of P50 (P less than 0.001) and that this effect is both rapidly inducible and reversible.	Nitrous Oxide	38-41	nuclear factor kappa B subunit 1	Homo sapiens	70-73
3494701-3	1987	Histone H2B from calf thymus was irradiated with 50 or 100 ns pulses of 16 MeV electrons in N2O-saturated aqueous solution at pH 9 in the presence of NaN3.	Nitrous Oxide	92-95	cuticle collagen 13	Bos taurus	0-11
3964518-1	1986	Methionine synthase activity was measured in 11 placentae after Caesarean section during which nitrous oxide had been used as an anaesthetic agent, and compared with that from 20 placentae after normal vaginal delivery with no exposure to nitrous oxide.	Nitrous Oxide	95-108	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-19
3723770-0	1986	Is nitrous oxide a dangerous anesthetic for vitamin B12-deficient subjects?	Nitrous Oxide	3-16	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	52-55
3558202-1	1987	Exposure of CD-1 mice to subanesthetic partial pressures of N2O (0.5 atm) or N2 (10-20 atm) for periods up to 14 days results in up to 40% decreases in the mean threshold pressure eliciting type I high-pressure neurological syndrome (HPNS) seizures, and in increases up to 38% in the N2 partial pressure producing anesthesia.	Nitrous Oxide	60-63	CD1 antigen complex	Mus musculus	12-16
3536916-0	1986	In vitro inactivation of methionine synthase by nitrous oxide.	Nitrous Oxide	48-61	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	25-44
3536916-2	1986	Prolonged exposure to N2O leads to megaloblastic anemia in humans and to loss of methionine synthase activity in vertebrates.	Nitrous Oxide	22-25	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	81-100
3536916-3	1986	We now report that purified preparations of cobalamin-dependent methionine synthase (5-methyltetrahydrofolate-homocysteine methyltransferase, EC 2.1.1.13) from both Escherichia coli and pig liver are irreversibly inactivated during turnover in buffers saturated with N2O.	Nitrous Oxide	267-270	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	64-83
16347228-7	1986	Denitrification was nitrate limited; however, the yields of N(2)O amounted to only 10 to 34% of the added nitrate when 100 muM nitrate was added.	Nitrous Oxide	60-65	latexin	Homo sapiens	123-126
3021443-2	1986	ACTH and beta-LPH concentrations in plasma rose significantly (P less than 0.001) during halothane-nitrous oxide anaesthesia.	Nitrous Oxide	99-112	proopiomelanocortin	Homo sapiens	9-17
3964518-0	1986	Effect of nitrous oxide on placental methionine synthase activity.	Nitrous Oxide	10-23	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	37-56
2994512-3	1985	Anaesthesia in man with halothane and nitrous oxide was found to be associated with a significant increase in plasma ACTH levels and beta-LPH levels.	Nitrous Oxide	38-51	proopiomelanocortin	Homo sapiens	117-121
2870665-1	1986	Fasting rats were exposed to nitrous oxide (70% N2O/30% O2) for 24 h, a period of time sufficient to inactivate methionine synthase (correct trivial name).	Nitrous Oxide	29-42	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	112-131
3951096-0	1986	Is nitrous oxide a dangerous anesthetic for vitamin B12-deficient subjects?	Nitrous Oxide	3-16	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	52-55
3951096-4	1986	It is postulated that nitrous oxide anesthesia may precipitate neurologic disease in people with unrecognized deficiency of vitamin B12.	Nitrous Oxide	22-35	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	132-135
3663573-2	1986	The effect of methylcobalamin inactivation by the anaesthetic gas nitrous oxide on the activity of the cobalamin-dependent methionine synthetase (5-methyltetrahydrofolate homocysteine methyltransferase; EC 2.1.1.13) reaction, and on DNA synthesis, in the fruit bat Rousettus aegyptiacus, was examined.	Nitrous Oxide	66-79	methionine synthase	Rousettus aegyptiacus	145-201
3898919-0	1985	Optimization of oxygenation by CPAP during one-lung anesthesia using nitrous oxide:oxygen.	Nitrous Oxide	69-82	centromere protein J	Homo sapiens	31-35
3524305-3	1986	Important events were the first demonstration of Koller"s local anaesthesia in the eye in 1884, the first intubation for anaesthesia in Heidelberg, performed by F. Kuhn of Kassel and the development by M. Neu of a rotameter apparatus for nitrous oxide/oxygen anaesthesia in 1910.	Nitrous Oxide	238-251	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	205-208
2868723-1	1986	Exposure of sheep to 36% nitrous oxide for 8 days (2-hr per day) led to 90%, 82% and 74% inhibition of 5-methyltetrahydrofolate-homocysteine methyltransferase in the liver, heart and brain, respectively, while there was no significant decrease in the activity of methylmalonyl-CoA mutase.	Nitrous Oxide	25-38	methionine synthase	Ovis aries	103-158
2868723-1	1986	Exposure of sheep to 36% nitrous oxide for 8 days (2-hr per day) led to 90%, 82% and 74% inhibition of 5-methyltetrahydrofolate-homocysteine methyltransferase in the liver, heart and brain, respectively, while there was no significant decrease in the activity of methylmalonyl-CoA mutase.	Nitrous Oxide	25-38	methylmalonyl-CoA mutase, mitochondrial	Ovis aries	263-287
3929875-7	1985	This study provides direct evidence that occupational exposure to nitrous oxide may cause depression of vitamin B12 activity resulting in measurable changes in bone marrow secondary to impaired synthesis of deoxyribonucleic acid.	Nitrous Oxide	66-79	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	112-115
2994512-3	1985	Anaesthesia in man with halothane and nitrous oxide was found to be associated with a significant increase in plasma ACTH levels and beta-LPH levels.	Nitrous Oxide	38-51	proopiomelanocortin	Homo sapiens	133-141
3975260-2	1985	These findings suggest that nitrous oxide might be capable of inducing the release of methionine-enkephalin in the central nervous system.	Nitrous Oxide	28-41	proenkephalin	Rattus norvegicus	97-107
16346745-1	1985	Two fast-growing strains of cowpea rhizobia (A26 and A28) were found to grow anaerobically at the expense of NO(3), NO(2), and N(2)O as terminal electron acceptors.	Nitrous Oxide	127-132	calmegin	Mus musculus	45-48
6609146-1	1984	The G values for single-strand breaks G(ssb) in polyuridylic acid (poly U) have been measured by low-angle laser light scattering in aqueous solutions under various conditions (e.g. in the presence of N2O, Ar and t-butanol).	Nitrous Oxide	201-204	small RNA binding exonuclease protection factor La	Homo sapiens	40-43
6395608-0	1984	Enkephalinase inhibition prevented tolerance to nitrous oxide analgesia in rats.	Nitrous Oxide	48-61	membrane metallo-endopeptidase	Rattus norvegicus	0-13
6721960-0	1984	Inhibition of fetal methionine synthase by nitrous oxide.	Nitrous Oxide	43-56	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	20-39
6721960-1	1984	The activity of the enzyme methionine synthase in fetal and maternal liver was investigated before and after exposure to nitrous oxide.	Nitrous Oxide	121-134	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	27-46
6721960-5	1984	Both fetal and maternal methionine synthase activity decreased progressively with increasing time of exposure to nitrous oxide and recovered only slowly after the agent was discontinued.	Nitrous Oxide	113-126	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	24-43
6609146-2	1984	In N2O-saturated solutions at room temperature and pH 5.6, the G(ssb) is 2.3.	Nitrous Oxide	3-6	small RNA binding exonuclease protection factor La	Homo sapiens	65-68
6631717-3	1983	Nitrous oxide treatment was used to inhibit the tetrahydrofolate-generating enzyme, 5-methyltetrahydrofolate homocysteine methyltransferase (methionine synthetase, E.C.	Nitrous Oxide	0-13	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	84-139
6666843-3	1983	During anaesthesia (fentanyl, pancuronium bromide, ventilation with N2O/O2 1: 1) there was a decrease in CI (26%), SI (18%), HR (5,7%), dp/dt (15%) and an increase in TSR (25%) and TPR (32%); Part, PAP, PCWP and PRA remained unchanged.	Nitrous Oxide	68-71	translocated promoter region, nuclear basket protein	Homo sapiens	181-184
6882609-0	1983	Effects of chronic exposure to nitrous oxide on methionine synthase activity.	Nitrous Oxide	31-44	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	48-67
6882609-1	1983	Hepatic methionine synthase activity has been determined in rats continuously exposed (24 h day-1 and 7 day week-1) to concentrations of nitrous oxide ranging from 500 to 50 000 p.p.m.	Nitrous Oxide	137-150	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	8-27
6865921-7	1983	Thus, nitrous oxide, in addition to its inhibitory effect on 5-methyltetrahydrofolate:homocysteine methyltransferase (methionine synthase, EC 2.1.1.13) activity, possesses another effect.	Nitrous Oxide	6-19	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	61-116
6865921-7	1983	Thus, nitrous oxide, in addition to its inhibitory effect on 5-methyltetrahydrofolate:homocysteine methyltransferase (methionine synthase, EC 2.1.1.13) activity, possesses another effect.	Nitrous Oxide	6-19	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	118-137
7091732-6	1982	In patients with MVS subjected to fentanyl anesthesia, N2O caused a marked increase in PVR from 357 to 530 dyn .	Nitrous Oxide	55-58	PVR cell adhesion molecule	Homo sapiens	87-90
6135251-3	1983	These findings indicate that the 2 vitamin B-12 dependent enzymes, methylmalonyl-CoA-mutase and methione synthetase, are depressed by nitrous oxide.	Nitrous Oxide	134-147	methylmalonyl-CoA mutase	Homo sapiens	67-91
6683088-2	1983	Predisposition to nitrous oxide withdrawal convulsions as judged by duration of susceptibility was decreased significantly after pretreatment with the cholinesterase inhibitors, physostigmine and galanthamine, or with the opiate receptor blocking agent naloxone.	Nitrous Oxide	18-31	butyrylcholinesterase	Mus musculus	151-165
6587794-0	1983	Nitrous oxide analgesia workshop as an aid in the teaching of first year respiratory physiology.	Nitrous Oxide	0-13	activation induced cytidine deaminase	Homo sapiens	39-42
6600887-15	1983	The data suggest that nitrous oxide blocks the effects of electrical stimulation at LI-4.	Nitrous Oxide	22-35	lipase family member N	Homo sapiens	84-88
7145941-0	1982	Cobalamin (vitamin B12) analogs are absent in plasma of fruit bats exposed to nitrous oxide.	Nitrous Oxide	78-91	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	19-22
18963404-3	1983	The barium in this solution is measured by AAS with a nitrous oxide-acetylene flame.	Nitrous Oxide	54-67	FYVE, RhoGEF and PH domain containing 1	Homo sapiens	43-46
6838615-0	1983	Effect of nitrous oxide-induced inactivation of vitamin B12 on glycinamide ribonucleotide transformylase and 5-amino-4-imidazole carboxamide transformylase.	Nitrous Oxide	10-23	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	56-59
7091732-10	1982	These results suggest that the preexisting PVR value is of more importance for the pulmonary vascular response to N2O than the influence of background anesthesia.	Nitrous Oxide	114-117	PVR cell adhesion molecule	Homo sapiens	43-46
7074405-2	1982	It is now known that nitrous oxide can react chemically with vitamin B12, oxidizing Cob(I)alamin to the inactive Cob(III) alamin form.	Nitrous Oxide	21-34	metabolism of cobalamin associated B	Homo sapiens	84-87
7074405-2	1982	It is now known that nitrous oxide can react chemically with vitamin B12, oxidizing Cob(I)alamin to the inactive Cob(III) alamin form.	Nitrous Oxide	21-34	metabolism of cobalamin associated B	Homo sapiens	113-116
7074405-4	1982	Nitrous oxide depresses the two known vitamin B12 dependent enzymes methylmalonyl CoA mutase and methionine synthetase by inactivation of their coenzymes adenosylcobalamin and methylcobalamin respectively.	Nitrous Oxide	0-13	methylmalonyl-CoA mutase	Homo sapiens	68-92
7306986-1	1981	5-Methyltetrahydrofolate homocysteine methyltransferase activity in human bone marrow cells obtained from patients undergoing surgical operation became low after about 4 hr of nitrous oxide (N2O) anesthesia.	Nitrous Oxide	176-189	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-55
6278126-1	1982	Nitrous oxide, like morphine, stimulates locomotor activity in the CD-1, C-57 and C-3H mouse strains.	Nitrous Oxide	0-13	CD1 antigen complex	Mus musculus	67-77
7306986-1	1981	5-Methyltetrahydrofolate homocysteine methyltransferase activity in human bone marrow cells obtained from patients undergoing surgical operation became low after about 4 hr of nitrous oxide (N2O) anesthesia.	Nitrous Oxide	191-194	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-55
6164371-0	1981	The effect of nitrous oxide-induced vitamin B12 deficiency on in vivo folate metabolism.	Nitrous Oxide	14-27	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	44-47
6975514-7	1981	rCBF was measured with 11C-IAP in nitrous oxide-anesthetized Wistar rats by the method of indicator fractionation, and values were compared with rCBF values measured with simultaneously administered commercially produced 14C-IAP.	Nitrous Oxide	34-47	CCAAT/enhancer binding protein zeta	Rattus norvegicus	0-4
7205659-3	1981	Nitrous oxide treatment was used to inhibit 5-methyltetrahydrofolate homocysteine methyltransferase (methionine synthetase, EC 4.2.99.10) in order to delineate the role of this enzyme in regulating the metabolism of formate in rats and in determining the sensitivity of this species to methanol intoxication.	Nitrous Oxide	0-13	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	44-99
7306876-9	1981	This agrees well with the nitrate partitioning observed by the acetylene inhibition method in which 30--40% of the NO3- -N was recovered as N2O.	Nitrous Oxide	140-143	NBL1, DAN family BMP antagonist	Homo sapiens	115-118
6971097-0	1980	The effect of nitrous oxide-induced inactivation of vitamin B12 on the activity of formyl-methenyl-methylenetetrahydrofolate synthetase, methylene-tetrahydrofolate reductase and formiminotetrahydrofolate transferase.	Nitrous Oxide	14-27	methylenetetrahydrofolate reductase	Homo sapiens	137-173
7457978-2	1981	Although quaking mice had significantly (15 to 23 per cent) lower nitrous oxide and cyclopropane rolling-response ED50S than did littermate controls, enflurane and isoflurane rolling-response ED50S were not significantly different.	Nitrous Oxide	66-79	quaking, KH domain containing RNA binding	Mus musculus	9-16
7328141-4	1981	An enhancement of the indomethacin response during nitrous oxide anesthesia was mainly observed in structures which show a maintained or increased CBF during anesthesia.	Nitrous Oxide	51-64	CCAAT/enhancer binding protein zeta	Rattus norvegicus	147-150
7463707-0	1980	[Serum myoglobin levels following administration of succinylcholine during nitrous oxide-oxygen-halothane anesthesia (author"s transl)].	Nitrous Oxide	75-88	myoglobin	Homo sapiens	7-16
571219-8	1979	A similar mechanism has been proposed to explain increased halothane concentrations delivered by Fluotec Mark 2 vaporizers in the presence of nitrous oxide.	Nitrous Oxide	142-155	microtubule affinity regulating kinase 2	Homo sapiens	105-111
7425334-4	1980	Rats exposed to N2O and control rats showed no difference in well-being, in caudal nerve conduction, in axonal content and transport of acetylcholinesterase and dopamine-beta-hydroxylase, or in number and size distribution and pathologic abnormality of teased myelinated fibers.	Nitrous Oxide	16-19	acetylcholinesterase	Rattus norvegicus	136-156
16345620-1	1980	During microaerophilic growth of magnetic spirillum MS-1 on tartrate and nitrate, a maximal cell density was obtained at an initial oxygen partial pressure of 17 Pa. A transient accumulation of nitrous oxide and a 1:2 (mol/mol) stoichiometry between tartrate oxidation and nitrate reduction were observed, indicating that the organism carried out a respiratory type of metabolism.	Nitrous Oxide	194-207	MS	Homo sapiens	52-56
6767537-4	1980	Of clinical importance, nitrous oxide/oxygen (75/25), compared with oxygen alone, increased the vapour concentration outputs of the halothane Mark 2 up to 30% and decreased the outputs of the enflurane Ohio unit up to 20%.	Nitrous Oxide	24-37	microtubule affinity regulating kinase 2	Homo sapiens	142-148
6101617-1	1980	Prior exposure of rats to a mixture of nitrous oxide/oxygen (80/20) for 20 to 24 hours and feeding rats a diet deficient in vitamin B-12 and methionine for 23 weeks resulted in a 86 to 90% decrease in the activity of the vitamin B-12 dependent enzyme, 5-methyltetrahydrofolate-homocysteine methyltransferase (EC 4.2.99.10).	Nitrous Oxide	39-52	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	252-307
6779497-8	1980	When PaCO2 was lowered to 30 Torr, under 70% nitrous oxide + 1% enflurane, there was a 43% decrease in CBF (from a mean of 42 ml/100 G/min.	Nitrous Oxide	45-58	CCAAT enhancer binding protein zeta	Homo sapiens	103-106
379022-12	1979	Microtubule inhibitors, such as colcemid and N2O, altered the appearance of tubulin- and calmodulin-specific fluorescence in mitotic CHO cells.	Nitrous Oxide	45-48	calmodulin 1	Rattus norvegicus	89-99
6892785-3	1980	Nitrous oxide reduced the transition by 0.58 degree C/atm.	Nitrous Oxide	0-13	MCOPCT1	Homo sapiens	52-57
7363899-0	1980	Inactivation of methionine synthase by nitrous oxide.	Nitrous Oxide	39-52	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	16-35
7363899-1	1980	Exposure of rats to a 50% N2O/oxygen mixture led to a rapid loss of methionine synthase activity in both liver and brain.	Nitrous Oxide	26-29	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	68-87
7363899-5	1980	Withdrawal of N2O was followed by a relatively slow recovery of methionine synthase activity over four days.	Nitrous Oxide	14-17	5-methyltetrahydrofolate-homocysteine methyltransferase	Rattus norvegicus	64-83
7189100-1	1980	The carrier gases--air, nitrous oxide/oxyten (50%/50%), and nitrous oxide (100%)--decreased the halothane output from Fluotec Mark 3 vaporizers an average of 87.9%, 85.4%, and 70.9%, respectively, as compared with the halothane output when oxygen was used as the carrier gas.	Nitrous Oxide	24-37	microtubule affinity regulating kinase 3	Homo sapiens	126-132
7189100-1	1980	The carrier gases--air, nitrous oxide/oxyten (50%/50%), and nitrous oxide (100%)--decreased the halothane output from Fluotec Mark 3 vaporizers an average of 87.9%, 85.4%, and 70.9%, respectively, as compared with the halothane output when oxygen was used as the carrier gas.	Nitrous Oxide	60-73	microtubule affinity regulating kinase 3	Homo sapiens	126-132
7392998-0	1980	[Oxidation of nitrous oxide during decomposition of hydrogen peroxide by catalase].	Nitrous Oxide	14-27	catalase	Homo sapiens	73-82
7392998-1	1980	Possible involvement of the catalase mechanism in the elimination of nitrous oxide was studied in model experiments.	Nitrous Oxide	69-82	catalase	Homo sapiens	28-36
7392998-2	1980	The concentration of N2O in the gaseous phase was found to decrease due to the decomposition of hydrogen peroxide by catalase.	Nitrous Oxide	21-24	catalase	Homo sapiens	117-125
7392998-3	1980	The concentration of NO increased accompanying the removal of N2O from the gaseous phase in the pressure of H2O2 and catalase.	Nitrous Oxide	62-65	catalase	Homo sapiens	108-125
7392998-4	1980	Though the observed effect is slight, the oxidation of nitrous oxide during the decomposition of H2O2 by catalase might be one of the mechanisms for biological elimination of N2O under the oxidating conditions.	Nitrous Oxide	55-68	catalase	Homo sapiens	105-113
7392998-4	1980	Though the observed effect is slight, the oxidation of nitrous oxide during the decomposition of H2O2 by catalase might be one of the mechanisms for biological elimination of N2O under the oxidating conditions.	Nitrous Oxide	175-178	catalase	Homo sapiens	105-113
459413-7	1979	Halothane plus nitrous oxide produced an increase in plasma renin activity, which then subsided to normal by 210 minutes following anesthesia; breathing room air did not result in increases in plasma renin activity.	Nitrous Oxide	15-28	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	60-65
398128-2	1979	Neutropenia following prolonged inhalation of nitrous oxide seems to be caused by a different mechanism, in which the cobalt in B12 is oxidised to the trivalent form by chemical reaction with nitrous oxide.	Nitrous Oxide	46-59	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	128-131
398128-2	1979	Neutropenia following prolonged inhalation of nitrous oxide seems to be caused by a different mechanism, in which the cobalt in B12 is oxidised to the trivalent form by chemical reaction with nitrous oxide.	Nitrous Oxide	192-205	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	128-131
398128-3	1979	B12 is thereby inactivated and this interferes with folate metabolism and thymidine synthesis: the effect may be detected after only a few hours in vivo exposure of mammals to 50% nitrous oxide.	Nitrous Oxide	180-193	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	0-3
82736-6	1978	The neurological picture is similar to that of subacute combined degeneration of the spinal cord, and it is possible that nitrous oxide interferes with the action of vitamin B12 in the nervous system.	Nitrous Oxide	122-135	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	174-177
207651-1	1978	The yields in molecules per 100 eV for active-site and sulphydryl loss from glyceraldehyde-3-phosphate dehydrogenase have been determined in nitrous-oxide-saturated, aerated and argon-saturated solutions.	Nitrous Oxide	141-154	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	76-116
916171-0	1977	[The effect of diazepam-ketamine-nitrous oxide anesthesia and surgery on plasma levels of thyroid hormones, growth hormone, and insulin in man (author"s transl)].	Nitrous Oxide	33-46	insulin	Homo sapiens	128-135
943990-6	1976	When N2O was discontinued, both agents increased PEP and PEP/LVET and decreased 1/PEP2 and the ejection fraction.	Nitrous Oxide	5-8	prolyl endopeptidase	Homo sapiens	49-52
269158-1	1977	Acute exposures of lungs to nitrous oxide in anesthetic concentration results in an initial lowered free activity of cathepsin D.	Nitrous Oxide	28-41	cathepsin D	Homo sapiens	117-128
952695-3	1976	After operation, the respiratory restoration factor (RRF) was used to indicate the pain relief from nitrous oxide (25%) and i.v.	Nitrous Oxide	100-113	mitochondrial ribosome recycling factor	Homo sapiens	21-51
952695-3	1976	After operation, the respiratory restoration factor (RRF) was used to indicate the pain relief from nitrous oxide (25%) and i.v.	Nitrous Oxide	100-113	mitochondrial ribosome recycling factor	Homo sapiens	53-56
848715-1	1977	The TM3 Gas differentiator, a simple device introduced to differentiate between nitrous oxide and oxygen, was found to be capable of positively distinguishing between these gases when only they were known to be present.	Nitrous Oxide	80-93	tropomyosin 3	Homo sapiens	4-7
938967-4	1976	Addition of nitrous oxide produced no further changes in cardiac output and arterial blood pressure but did increase urine output, PAH, inulin and free water clearances and decreased urine osmolarity.	Nitrous Oxide	12-25	phenylalanine hydroxylase	Canis lupus familiaris	131-134
1276004-3	1976	The output of the Fluotec Mark 2 at the 0.5 and 1% settings was highest with nitrous oxide as the carrier gas, but at 2, 3 and 4% settings it was highest with oxygen; at the 0.5% and 1% dial settings it was a function of carrier gas density, but at 2%, 3% and 4% it was a function of carrier gas viscosity.	Nitrous Oxide	77-90	microtubule affinity regulating kinase 2	Homo sapiens	26-32
943990-6	1976	When N2O was discontinued, both agents increased PEP and PEP/LVET and decreased 1/PEP2 and the ejection fraction.	Nitrous Oxide	5-8	prolyl endopeptidase	Homo sapiens	57-81
1125335-1	1975	Functional ethanolamine ammonia-lyase is inactivated by N2O as well as by O2, indicating that the active form of coenzyme B12 is an enzyme-bound corrin derivative in which the Co-C bond of the coenzyme is broken and the cobalt ion is in the +1 state of oxidation.	Nitrous Oxide	56-59	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	122-125
1162942-2	1975	In patients treated surgically without any preliminary pneumoencephalographic investigation the normo- and hypocapnic artificial ventilation of the lungs with a N2O and O2 mixture produced a significant drop of the CSF pressure.	Nitrous Oxide	161-164	colony stimulating factor 2	Homo sapiens	215-218
20282080-0	1947	Ocular and systemic manifestations of a cholinergic episode following nitrous oxide anesthesia; diminished blood cholinesterase in a protracted cholinergic state.	Nitrous Oxide	70-83	butyrylcholinesterase	Homo sapiens	113-127
5156319-0	1971	Metabolic effects of anaesthesia: effect of thiopentone-nitrous oxide anaesthesia on human growth hormone and insulin levels in plasma.	Nitrous Oxide	56-69	growth hormone 1	Homo sapiens	91-105
5102908-0	1971	[Effect of droperidol-pentazocine-nitrous oxide anesthesia and surgical stress on the levels of HGH and insulin in the blood].	Nitrous Oxide	34-47	insulin	Homo sapiens	104-111
5531037-0	1970	[Effects of thiopental-nitrous oxide anesthesia and surgical stress on plasma human growth hormone and insulin levels].	Nitrous Oxide	23-36	growth hormone 1	Homo sapiens	84-98
13544064-0	1957	[A portable device for nitrous oxide anesthesia for first aid].	Nitrous Oxide	23-36	activation induced cytidine deaminase	Homo sapiens	58-61
33957419-5	2021	However, the combined application (NNK) of K and NN significantly reduced the average N2O emissions by 28.3%, while the combined application (ANK) of K and AN increased N2O emissions by 22.7%.	Nitrous Oxide	169-172	ankyrin 1	Homo sapiens	142-145
33257072-2	2021	Current knowledge gaps include how nitrification-related N2O is associated with soil microbes in different pH soils.	Nitrous Oxide	57-60	phenylalanine hydroxylase	Homo sapiens	107-109
34030255-7	2021	The CW was a very weak source of N2O emitting 0.32 kg N2O-N ha-1 yr-1 and removing around 938 kg NO3--N ha-1 yr-1, the ratio of N2O-N emitted to NO3--N removed was 0.033%.	Nitrous Oxide	33-36	solute carrier family 9 member B1	Homo sapiens	58-69
33706089-8	2021	The average annual N2O emission during the baseline period was between 1.8 and 4.1 kg ha-1 depending on AEZ.	Nitrous Oxide	19-22	Rho GTPase activating protein 45	Homo sapiens	86-90
33706089-10	2021	From 2015 to 2085 under RCP 4.5, the average N2O emission was between 1.8 and 4.4 kg ha-1 year-1.	Nitrous Oxide	45-48	CGRP receptor component	Homo sapiens	24-27
33714807-11	2021	This ratio yielded 1.03 kg ha-1 N2O emissions, which was 15% lesser than the N2O emission of CK, 1.21 kg ha-1.	Nitrous Oxide	32-35	1,4-alpha-glucan-branching enzyme 2, chloroplastic/amyloplastic	Zea mays	27-31
33257072-9	2021	The results showed that N2O yield for AOA and AOB varied with soil pH.	Nitrous Oxide	24-27	phenylalanine hydroxylase	Homo sapiens	67-69
33257072-14	2021	To conclude, soil pH was a key factor affecting the contribution of ammonia oxidizers to nitrification-related N2O emissions.	Nitrous Oxide	111-114	phenylalanine hydroxylase	Homo sapiens	18-20
33987886-4	2021	The NO3 - produced by this reaction is chemically converted to N2 O, and continuous-flow isotope ratio mass spectrometry (CF-IRMS) is used to determine the oxygen isotopic compositions.	Nitrous Oxide	63-67	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
33966117-6	2021	At 90% WHC, Met + C treatment significantly lessened concentrations of NH4+ and NO3-, nonetheless improved N2O compared to Met treatment.	Nitrous Oxide	107-110	SAFB like transcription modulator	Homo sapiens	12-15
33609882-1	2021	This study focused on the nitrous oxide (N2O) generation from the biological nitrogen removal process under different pH levels.	Nitrous Oxide	26-39	phenylalanine hydroxylase	Homo sapiens	118-120
33609882-1	2021	This study focused on the nitrous oxide (N2O) generation from the biological nitrogen removal process under different pH levels.	Nitrous Oxide	41-44	phenylalanine hydroxylase	Homo sapiens	118-120
33609882-3	2021	The mean gaseous N2O emission accounted for 0.329%, 0.103%, 0.085%, and 0.793% of the influent total nitrogen at pH of 5, 6, 8, and 9, respectively.	Nitrous Oxide	17-20	phenylalanine hydroxylase	Homo sapiens	113-115
33609882-6	2021	The impacts of pH on N2O generation were more likely related to the response of bacterial enzymes and nitrogen compounds, rather than the feedback of bacterial community structure itself.	Nitrous Oxide	21-24	phenylalanine hydroxylase	Homo sapiens	15-17
33609882-7	2021	Above all, an influent pH range of 6-8 is recommended for nitrogen removal and N2O mitigation in anoxic-oxic process.	Nitrous Oxide	79-82	phenylalanine hydroxylase	Homo sapiens	23-25
33927908-4	2021	Uncommonly suspected causes of B12 deficiency include the abuse of recreational nitrous oxide (NO) given its interference with cobalt oxidation.	Nitrous Oxide	80-93	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	31-34
33429272-5	2021	NH4NO3 addition of 50 kg N ha-1 yr-1 significantly increased organic N derived N2O on the 6th day after N addition, which suggests that heterotrophic nitrification may be the dominating process with higher N deposition rate.	Nitrous Oxide	79-82	solute carrier family 9 member B1	Homo sapiens	25-36
33461241-12	2021	Normalising CRDS & SSIM delta values to the international isotope-ratio scales using isotopic N2 O standards (AK1 and Mix1) produced accurate results when the samples were bracketed within the range of the delta values of the standards.	Nitrous Oxide	94-98	adenylate kinase 1	Homo sapiens	110-113
33759511-0	2021	Wintertime Nitrous Oxide Emissions in the San Joaquin Valley of California Estimated from Aircraft Observations.	Nitrous Oxide	11-24	N-alpha-acetyltransferase 50, NatE catalytic subunit	Homo sapiens	42-45
33111387-1	2021	A nickel complex incorporating an N2O ligand with a rare eta2-N,N"-coordination mode was isolated and characterized by X-ray crystallography, as well as by IR and solid-state NMR augmented by 15N-labeling experiments.	Nitrous Oxide	34-37	DNA polymerase iota	Homo sapiens	57-61
33755454-8	2021	Then, we investigated the reactivities of the (mu-eta2:eta2-NO2)dicopper complex toward methane and benzene by considering the conversions of N2O to N2 in the presence and the absence of methane or benzene.	Nitrous Oxide	142-145	DNA polymerase iota	Homo sapiens	50-54
33755454-8	2021	Then, we investigated the reactivities of the (mu-eta2:eta2-NO2)dicopper complex toward methane and benzene by considering the conversions of N2O to N2 in the presence and the absence of methane or benzene.	Nitrous Oxide	142-145	DNA polymerase iota	Homo sapiens	55-59
33755454-10	2021	Thus, the (mu-eta2:eta2-NO2)dicopper complex prefers the reactions with methane and benzene to that with N2O.	Nitrous Oxide	105-108	DNA polymerase iota	Homo sapiens	14-18
33755454-10	2021	Thus, the (mu-eta2:eta2-NO2)dicopper complex prefers the reactions with methane and benzene to that with N2O.	Nitrous Oxide	105-108	DNA polymerase iota	Homo sapiens	19-23
33755454-12	2021	The (mu-nitrosyl)dicopper complex then reacted with N2O to regenerate the (mu-eta2:eta2-NO2)dicopper complex and N2 with an activation barrier of 31.5 kcal/mol.	Nitrous Oxide	52-55	DNA polymerase iota	Homo sapiens	78-82
33755454-12	2021	The (mu-nitrosyl)dicopper complex then reacted with N2O to regenerate the (mu-eta2:eta2-NO2)dicopper complex and N2 with an activation barrier of 31.5 kcal/mol.	Nitrous Oxide	52-55	DNA polymerase iota	Homo sapiens	83-87
31524076-4	2021	During the 1st and 2nd WWTs, biological heterotrophic dissimilative NO3- denitrification was confirmed by simultaneous detection of both NO2- and N2O and significant production of CO2 during the NO3- degradation.	Nitrous Oxide	146-149	NBL1, DAN family BMP antagonist	Homo sapiens	68-71
34012824-12	2021	Results: We observed a significant association both FeNO, nNO level with eosinophils, total IgE.	Nitrous Oxide	58-61	immunoglobulin heavy constant epsilon	Homo sapiens	92-95
33476139-0	2021	Recovery of N2O: Energy-Efficient and Structure-Driven Clathrate-Based Greenhouse Gas Separation.	Nitrous Oxide	12-15	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	82-85
33476139-2	2021	We present here an energy-efficient clathrate-based greenhouse gas-separation (CBGS) technology that can operate at room temperature for selectively recovering N2O from gas mixtures.	Nitrous Oxide	160-163	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	63-66
33476139-2	2021	We present here an energy-efficient clathrate-based greenhouse gas-separation (CBGS) technology that can operate at room temperature for selectively recovering N2O from gas mixtures.	Nitrous Oxide	160-163	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	169-172
33476139-3	2021	Clathrate formation between alpha-form/beta-form hydroquinone (alpha-HQ/beta-HQ) and gas mixtures reveals guest-specific and structure-driven selectivity, revealing the preferential capture of N2O in beta-HQ and the molecular sieving characteristics of alpha-HQ.	Nitrous Oxide	193-196	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	85-88
33476139-4	2021	With a maximum gas storage capacity and cage occupancy of 54.1 cm3 g-1 and 0.86, respectively, HQ clathrate compounds including N2O are stable at room temperature and atmospheric pressure and thus can be easily synthesized, treated, and recycled via commercial CBGS processes.	Nitrous Oxide	128-131	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	15-18
33476139-5	2021	High selectivity for N2O recovery was observed during beta-HQ clathrate formation from N2O/N2 gas mixtures with N2O concentrations exceeding 20%, whereas alpha-HQ traps only N2 molecules from gas mixtures.	Nitrous Oxide	21-24	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	94-97
33722915-0	2021	Inhaled nitrous oxide-induced functional B12 deficiency.	Nitrous Oxide	8-21	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	41-44
33600449-1	2021	PURPOSE: A rapid increase of recreational nitrous oxide use (i.e. laughing gas, N2O) has been reported in several countries, while it has received limited attention in scientific research.	Nitrous Oxide	42-55	gastrin	Homo sapiens	75-78
33434865-5	2021	The annual mean soil N2O emission from fertilized greenhouse vegetable systems was 12.0 +- 1.0 kg N2O-N ha-1 yr-1 (global: 0.067 Tg N2O-N yr-1), with N2O emissions increasing exponentially with fertilization.	Nitrous Oxide	21-24	solute carrier family 9 member B1	Homo sapiens	102-113
33434865-5	2021	The annual mean soil N2O emission from fertilized greenhouse vegetable systems was 12.0 +- 1.0 kg N2O-N ha-1 yr-1 (global: 0.067 Tg N2O-N yr-1), with N2O emissions increasing exponentially with fertilization.	Nitrous Oxide	98-101	solute carrier family 9 member B1	Homo sapiens	102-113
33434865-5	2021	The annual mean soil N2O emission from fertilized greenhouse vegetable systems was 12.0 +- 1.0 kg N2O-N ha-1 yr-1 (global: 0.067 Tg N2O-N yr-1), with N2O emissions increasing exponentially with fertilization.	Nitrous Oxide	98-101	solute carrier family 9 member B1	Homo sapiens	102-113
33434865-5	2021	The annual mean soil N2O emission from fertilized greenhouse vegetable systems was 12.0 +- 1.0 kg N2O-N ha-1 yr-1 (global: 0.067 Tg N2O-N yr-1), with N2O emissions increasing exponentially with fertilization.	Nitrous Oxide	98-101	solute carrier family 9 member B1	Homo sapiens	102-113
33434865-10	2021	Yield-scaled N2O emissions (0.05 +- 0.01 kg N2O-N Mg-1 yr-1) and nitrogen leaching (0.79 +- 0.08 kg N Mg-1 yr-1) were lowest at fertilizer rates <1000 kg N ha-1 yr-1.	Nitrous Oxide	13-16	solute carrier family 9 member B1	Homo sapiens	154-165
33434865-12	2021	Our study indicates that high environmental N2O and N leaching losses can be mitigated by reducing fertilization rates to 500-1000 kg N ha-1 yr-1 (mean: ~762 kg N ha-1 yr-1) without jeopardizing yields.	Nitrous Oxide	44-47	solute carrier family 9 member B1	Homo sapiens	134-145
33434865-12	2021	Our study indicates that high environmental N2O and N leaching losses can be mitigated by reducing fertilization rates to 500-1000 kg N ha-1 yr-1 (mean: ~762 kg N ha-1 yr-1) without jeopardizing yields.	Nitrous Oxide	44-47	solute carrier family 9 member B1	Homo sapiens	161-172
33480896-0	2021	Synthetic and natural MOR zeolites as high-capacity adsorbents for the removal of nitrous oxide.	Nitrous Oxide	82-95	opioid receptor mu 1	Homo sapiens	22-25
33480896-2	2021	We herein demonstrate that ion-exchanged mordenite zeolites (framework code: MOR) can exhibit high capacities for N2O adsorption under ambient conditions.	Nitrous Oxide	114-117	opioid receptor mu 1	Homo sapiens	77-80
33480896-3	2021	In particular, a natural MOR zeolite gives an adsorption capacity as high as 0.34 mmol-N2O per g-zeolite (1 atm, 25  C), representing the best performing material among all zeolite-based adsorbents reported so far.	Nitrous Oxide	87-90	opioid receptor mu 1	Homo sapiens	25-28
32333625-7	2020	SCIENTIFIC SIGNIFICANCE: Current literature suggests that psychosis associated with nitrous oxide use is transient and resolves upon cessation and treatment of vitamin B12 deficiency.	Nitrous Oxide	84-97	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	168-171
33006095-4	2021	Both B2 and B5 significantly reduced the N2O emissions from the HNF by 15.7% and 13.2%, respectively, and reduced the N2O emissions from the DF by 40.9% and 11.7%, respectively.	Nitrous Oxide	41-44	immunoglobulin kappa variable 5-2	Homo sapiens	5-14
33006095-4	2021	Both B2 and B5 significantly reduced the N2O emissions from the HNF by 15.7% and 13.2%, respectively, and reduced the N2O emissions from the DF by 40.9% and 11.7%, respectively.	Nitrous Oxide	118-121	immunoglobulin kappa variable 5-2	Homo sapiens	5-14
32840941-8	2021	CONCLUSIONS: The denitrifier method for converting NO3 - to N2 O for isotope analysis was optimized.	Nitrous Oxide	60-64	NBL1, DAN family BMP antagonist	Homo sapiens	51-54
33642336-6	2021	In addition, N2O may mediate epigenetic changes by inhibiting methionine synthase, a key enzyme involved in DNA and RNA methylation.	Nitrous Oxide	13-16	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	62-81
33708398-2	2021	Nitro-sonium nitrate (NO+NO3 -), known for this property, has attracted a large interest in recent decades and was reported to be synthesized at high pressure and high temperature from a variety of nitro-gen-oxygen precursors, such as N2O4, N2O and N2-O2 mixtures.	Nitrous Oxide	235-238	NBL1, DAN family BMP antagonist	Homo sapiens	25-28
33546285-5	2021	The NO is bound to myoglobin (Mb) or metmyoglobin (Met-Mb), forming a complex, which is subsequently released using sulfuric acid, which also favors the reduction to N2O.	Nitrous Oxide	166-169	myoglobin	Homo sapiens	19-28
33550905-16	2021	Therefore, caution is advised in using N2O in Saudi children as the increased prevalence of this MTHFR allele may increase the incidence of serious adverse effects among these children.	Nitrous Oxide	39-42	methylenetetrahydrofolate reductase	Homo sapiens	97-102
32415454-6	2020	Among the optimized N fertilizer rates compared with the SNOpt treatment, the SNOpt +DCD and SSROpt treatments decreased in N2O emissions by approximately 55% and 13%, respectively.	Nitrous Oxide	124-127	dermcidin	Homo sapiens	85-88
33067760-1	2021	PURPOSE: Conscious sedation by inhalation of a mixture of nitrous oxide and oxygen (CS) is a technique used in dental care for anxious, handicapped or uncooperative patients.	Nitrous Oxide	58-71	citrate synthase	Homo sapiens	84-86
32887004-5	2020	Results showed that the cumulative CO2 and N2O emission from 9000 kg ha-1 of maize straw mulch with 192 kg N ha-1 (S3N2) significantly decreased by 0.67% and 33.7%, respectively, averaged over two years compared with that of 9000 kg ha-1 of maize straw mulch with 240 kg N ha-1 (S3N3).	Nitrous Oxide	43-46	1,4-alpha-glucan-branching enzyme 2, chloroplastic/amyloplastic	Zea mays	69-73
32887004-5	2020	Results showed that the cumulative CO2 and N2O emission from 9000 kg ha-1 of maize straw mulch with 192 kg N ha-1 (S3N2) significantly decreased by 0.67% and 33.7%, respectively, averaged over two years compared with that of 9000 kg ha-1 of maize straw mulch with 240 kg N ha-1 (S3N3).	Nitrous Oxide	43-46	1,4-alpha-glucan-branching enzyme 2, chloroplastic/amyloplastic	Zea mays	109-113
32512423-6	2020	Interestingly, at high soil salinity, Ag2S significantly increased cumulative N2O emissions from 80.9 to 229.2 mg kg-1 dry soil (by 180%) compared to the corresponding control sludge treatment, which was ascribed to the increased abundance of nitrification and denitrification-related genes (amoA, nxrB, narG, napA, nirS, and nosZ) and increased relative abundance of denitrifiers (Rhodanobacter, Salinimicrobium, and Zunongwangia).	Nitrous Oxide	78-81	angiotensin II receptor type 1	Homo sapiens	38-42
32502870-10	2020	BC amendment to DM1, DM2 and IN significantly reduced cumulative CO2 emission by 16, 25.5 and 26.5%, CH4 emission by 184, 200 and 293% and N2O emission by 95, 86 and 93% respectively.	Nitrous Oxide	139-142	DM1 protein kinase	Homo sapiens	16-19
32512423-7	2020	Together, our findings show that the application of Ag2S-containing sludge to a saline soil can disrupt the N cycle and increase N2O emissions from agroecosystems.	Nitrous Oxide	129-132	angiotensin II receptor type 1	Homo sapiens	52-56
32988057-1	2020	We demonstrate an improvement in the photoresponse characteristics of ultraviolet (UV) photodetectors (PDs) using the N2O plasma-treated ZnO nanorod (NR) gated AlGaN/GaN high electron mobility transistor (HEMT) structure.	Nitrous Oxide	118-121	gigaxonin	Homo sapiens	162-165
32502870-10	2020	BC amendment to DM1, DM2 and IN significantly reduced cumulative CO2 emission by 16, 25.5 and 26.5%, CH4 emission by 184, 200 and 293% and N2O emission by 95, 86 and 93% respectively.	Nitrous Oxide	139-142	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	21-24
32900205-0	2020	On the Role of Spin in the Catalytic Oxidation of CO by N2O Enabled by Co+: New Insights from Temperature Dependent Kinetics and Statistical Modeling.	Nitrous Oxide	56-59	spindlin 1	Homo sapiens	15-19
32983349-2	2020	Frequent exposure to nitrous oxide can lead to neurologic complications, including B12 deficiency and resultant subacute myeloneuropathy, as well as direct neurotoxicity.	Nitrous Oxide	21-34	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	83-86
32718428-6	2020	Nitrous oxide is known to inhibit methionine synthase, a vitamin B12-dependent enzyme responsible for the breakdown of homocysteine, resulting in homocysteine elevation, and should be avoided in these patients.	Nitrous Oxide	0-13	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	34-53
32785404-0	2020	Free electron laser infrared action spectroscopy of nitrous oxide binding to platinum clusters, Ptn(N2O).	Nitrous Oxide	52-65	pleiotrophin	Homo sapiens	96-99
32785404-0	2020	Free electron laser infrared action spectroscopy of nitrous oxide binding to platinum clusters, Ptn(N2O).	Nitrous Oxide	100-103	pleiotrophin	Homo sapiens	96-99
32785404-1	2020	Infrared multiple-photon dissociation spectroscopy has been applied to study Ptn(N2O)+ (n = 1-8) clusters which represent entrance-channel complexes on the reactive potential energy surface for nitrous oxide decomposition on platinum.	Nitrous Oxide	194-207	pleiotrophin	Homo sapiens	77-80
32785404-3	2020	Enhanced reactivity of Ptn+ n >= 6 clusters towards N2O is reflected in the calculated reactive potential energy surfaces and, uniquely in the size range studied, Pt6(N2O)+ proved impossible to form in significant number density even with cryogenic cooling of the cluster source.	Nitrous Oxide	52-55	pleiotrophin	Homo sapiens	23-26
32785404-4	2020	Infrared-driven N2O decomposition, resulting in the formation of cluster oxides, PtnO+, is observed following vibrational excitation of several Ptn(N2O)+ complexes.	Nitrous Oxide	16-19	pleiotrophin	Homo sapiens	81-84
33088274-7	2020	In particular, the antidepressant-like effects of N2O were also antagonized by local nNOS inhibition in the mPFC.	Nitrous Oxide	50-53	nitric oxide synthase 1	Homo sapiens	85-89
33088274-8	2020	In summary, our results indicated that N2O exposure enhances BDNF expression levels and burst firing rates in an nNOS activation dependent manner, which might underlie the pharmacological mechanism of the antidepressant-like effects of N2O exposure.	Nitrous Oxide	39-42	brain derived neurotrophic factor	Homo sapiens	61-65
33088274-8	2020	In summary, our results indicated that N2O exposure enhances BDNF expression levels and burst firing rates in an nNOS activation dependent manner, which might underlie the pharmacological mechanism of the antidepressant-like effects of N2O exposure.	Nitrous Oxide	39-42	nitric oxide synthase 1	Homo sapiens	113-117
33088274-8	2020	In summary, our results indicated that N2O exposure enhances BDNF expression levels and burst firing rates in an nNOS activation dependent manner, which might underlie the pharmacological mechanism of the antidepressant-like effects of N2O exposure.	Nitrous Oxide	236-239	brain derived neurotrophic factor	Homo sapiens	61-65
33088274-8	2020	In summary, our results indicated that N2O exposure enhances BDNF expression levels and burst firing rates in an nNOS activation dependent manner, which might underlie the pharmacological mechanism of the antidepressant-like effects of N2O exposure.	Nitrous Oxide	236-239	nitric oxide synthase 1	Homo sapiens	113-117
32498160-7	2020	Relative to the control, B15 and B30 reduced CH4 emission by 124% and 132% as averaged over 2-yr. With biochar amendments, total N2O emission was decreased by 71-110% and 39-47% in the first and second year.	Nitrous Oxide	129-132	NADH:ubiquinone oxidoreductase subunit B4	Homo sapiens	25-28
33088274-0	2020	Repeated Nitrous Oxide Exposure Exerts Antidepressant-Like Effects Through Neuronal Nitric Oxide Synthase Activation in the Medial Prefrontal Cortex.	Nitrous Oxide	9-22	nitric oxide synthase 1	Homo sapiens	75-105
33088274-4	2020	We hypothesized that activation of the nNOS/NO pathway in the medial prefrontal cortex (mPFC) might mediate the antidepressant effects of N2O.	Nitrous Oxide	138-141	nitric oxide synthase 1	Homo sapiens	39-43
33088274-6	2020	Our mechanistic exploration showed that repeated N2O exposure increased burst firing activity and that the expression levels of BDNF with nNOS activation were dependent in the mPFC.	Nitrous Oxide	49-52	brain derived neurotrophic factor	Homo sapiens	128-132
32599127-4	2020	The decrease in frequency induced by N2O was observed in sIPSCs but not in mIPSCs, which was recorded in the presence of both tetrodotoxin and Cd2+, which block voltage-gated Na+ and Ca2+ channels, respectively.	Nitrous Oxide	37-40	Cd2 molecule	Rattus norvegicus	143-146
32921491-0	2020	From ACE to ACENO: How America"s Munson added Harley"s British mixture to nitrous oxide.	Nitrous Oxide	74-87	angiotensin I converting enzyme	Homo sapiens	5-8
32020664-6	2020	We found that in human umbilical vein endothelial cells (HUVECs), TGF-beta1 treatment significantly decreased the expression of nuclear factor erythroid-2-related factor 2 (NRF-2), dimethylarginine dimethylaminohydrolase-1 (DDAH1), and VE-cadherin, the secretion of cellular nitric oxide (NO) and the activity of nitrous oxide synthase (NOS), while asymmetric dimethylarginine (ADMA) and the release of inflammatory factors were elevated.	Nitrous Oxide	313-326	transforming growth factor beta 1	Homo sapiens	66-75
32849729-4	2020	Contrarily, aseptically grown plants and axenic algal cells supplied with nitrate (NO3) are reported to emit N2O, indicating that it is produced inside plant cells by some unknown physiological phenomena.	Nitrous Oxide	109-112	NBL1, DAN family BMP antagonist	Homo sapiens	83-86
32849729-13	2020	As NO3 is a major source of nitrogen for plants and all plants may experience hypoxic and anoxic conditions owing to soil environmental factors, a significant global biogenic source of N2O may be its formation in plants via the proposed pathway.	Nitrous Oxide	185-188	NBL1, DAN family BMP antagonist	Homo sapiens	3-6
32608914-4	2020	Cumulative N2O emission under urea treatment alone (CN) was 1.78 kg hm-2 with a N2O emission factor of 0.38%.	Nitrous Oxide	11-14	Putative anthocyanidin reductase	Zea mays	68-72
32608914-6	2020	In contrast, application of urea in combination with PCU (with the proportion varied from 30%-70%) increased N2O emission by 0.02-0.41 kg hm-2 compared with the CN, while 30% urea+70% PCU treatment showed a 23.0% increase.	Nitrous Oxide	109-112	Putative anthocyanidin reductase	Zea mays	138-142
32574492-3	2020	The mechanism of this promising transformation was unveiled by means of experiments together with density functional theory (DFT) calculations, which inspired Milstein and co-workers to use similar (PNN)Ru-H pincer catalysts for the reduction of N2O by CO to produce N2 and CO2.	Nitrous Oxide	246-249	pinin, desmosome associated protein	Homo sapiens	199-202
32124508-5	2020	Alternative fates of NO3 - became increasingly important at higher sulphide treatments, which could include N2 O production and/or transport into intracellular vacuoles.	Nitrous Oxide	108-112	NBL1, DAN family BMP antagonist	Homo sapiens	21-24
32213406-7	2020	In BAF2, N2O was emitted from AOB denitrification and hydroxylamine oxidation by 87.8% and 12.2%, respectively.	Nitrous Oxide	9-12	BANF family member 2	Homo sapiens	3-7
32213406-8	2020	Heterotrophic denitrification is a N2O sink in BAF, causing BAF1 produced less N2O than BAF2 with the same gas-water ratio.	Nitrous Oxide	35-38	BANF family member 2	Homo sapiens	88-92
32301539-1	2020	Soil nitrification, an important pathway of nitrogen transformation in ecosystems, produces soil nitrate that influences net primary productivity, while the by-product of nitrification, nitrous oxide, is a significant green-house gas.	Nitrous Oxide	186-199	gastrin	Homo sapiens	230-233
32222508-5	2020	We confirmed denitrification producing di-nitrogen gas (N2) to be the primary NO3- removal pathway, but found that 6% of NO3- could be released as N2O under high NO3- concentrations and low amounts of bioavailable C, whereas DNRA rates tend to increase with the C amount.	Nitrous Oxide	147-150	NBL1, DAN family BMP antagonist	Homo sapiens	121-124
32222508-5	2020	We confirmed denitrification producing di-nitrogen gas (N2) to be the primary NO3- removal pathway, but found that 6% of NO3- could be released as N2O under high NO3- concentrations and low amounts of bioavailable C, whereas DNRA rates tend to increase with the C amount.	Nitrous Oxide	147-150	NBL1, DAN family BMP antagonist	Homo sapiens	121-124
32608651-8	2020	In the maize season, N2O emission was 0.50 kg hm-2 under CK treatment, and increased to 2.28 kg hm-2 under NPK treatment.	Nitrous Oxide	21-24	Putative anthocyanidin reductase	Zea mays	46-50
32286811-3	2020	Borylphosphine reacts with N2O via insertion of a single oxygen atom into the P-B bond and formation of a P-O-B bond system.	Nitrous Oxide	27-30	ER membrane protein complex subunit 3	Homo sapiens	106-111
32773885-6	2020	For three model spin-crossing reactions [predissociation of N2O, singlet-triplet conversion in CH2, and CO addition to Fe(CO)4], the spin-crossing points were obtained.	Nitrous Oxide	60-63	spindlin 1	Homo sapiens	16-20
32215417-6	2020	Herein, we provide a detailed and systematic description of the decomposition for unit-cell alpha-RDX and epsilon-CL-20 under increased temperature, which can be summarized as C3H6O6N6 (RDX)   NO + HNO + H2 + CO2 + HCHO + HNCN + N2O and C6H6O12N12 (CL-20)   NO + HONO + 5HCN + CO2 + N2O + 3NO2.	Nitrous Oxide	229-232	epithelial membrane protein 1	Homo sapiens	114-119
32215417-6	2020	Herein, we provide a detailed and systematic description of the decomposition for unit-cell alpha-RDX and epsilon-CL-20 under increased temperature, which can be summarized as C3H6O6N6 (RDX)   NO + HNO + H2 + CO2 + HCHO + HNCN + N2O and C6H6O12N12 (CL-20)   NO + HONO + 5HCN + CO2 + N2O + 3NO2.	Nitrous Oxide	283-286	epithelial membrane protein 1	Homo sapiens	114-119
32195121-2	2020	N2O prolonged and recurrent administration is known to affect vitamin B12 metabolism with subsequent clinical consequences.	Nitrous Oxide	0-3	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	70-73
32195121-3	2020	We report herein the case of a 13-year-old girl with sickle cell disease exhibiting severe neurological and biochemical signs of functional vitamin B12 deficiency due to prolonged and repeated exposure to N2O.	Nitrous Oxide	205-208	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	148-151
32195121-4	2020	This was an incentive to prospectively investigate functional vitamin B12 deficiency in patients affected by sickle cell disease regularly exposed to N2O.	Nitrous Oxide	150-153	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	70-73
32195121-7	2020	The clinical case highlight the potential severe deleterious effects of N2O over exposure on B12 vitamin metabolism in particular in patients affected with sickle cell disease.	Nitrous Oxide	72-75	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	93-96
31465582-10	2020	Hence, our results provide evidence that forest streams can act as substantial N2 O sources in the landscape with 800x109 g CO2 -eq emitted annually in Sweden, equivalent to 25% of the total N2 O emissions from the Swedish agricultural sector.	Nitrous Oxide	79-83	complement C2	Homo sapiens	124-127
32047246-10	2020	The most pronounced differences in functional distance during nitrous oxide sedation were observed in the alpha1 and alpha2 frequency bands.	Nitrous Oxide	62-75	BCL2 related protein A1	Homo sapiens	106-123
31914728-5	2020	Experimental results indicate that the hypergolic reaction of BMIM+DCBH- with WFNA generates both common and unique intermediates as compared to previous BMIM+DCA- + WFNA investigations: nitrous oxide was generated during both hypergolic reactions indicating that it may play a crucial role in the hypergolic ignition process, NO2 was generated in significantly higher concentrations for BMIM+DCBH- than for BMIM+DCA-, CO2 was only generated for BMIM+DCA-, and HCN was only generated during thermal decomposition and hypergolic ignition of BMIM+DCBH-.	Nitrous Oxide	187-200	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	461-464
31420725-0	2019	N2O production from hydroxylamine oxidation and corresponding hydroxylamine oxidoreductase involved in a heterotrophic nitrifier A. faecalis strain NR.	Nitrous Oxide	0-3	NAD(P)-dependent oxidoreductase	Alcaligenes faecalis	76-90
31796450-3	2019	It</protein-id> was initially felt she had been suffering from tuberculous meningitis and started on treatment it later became apparent that she had a severe vitamin B12 deficiency related to recreational nitrous oxide use.	Nitrous Oxide	205-218	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	166-169
31667903-6	2020	In this article, we review the biochemical basis and scientific observations that suggest a significant interaction between N2 O and methotrexate due to their dual inhibition of the key enzyme methionine synthase.	Nitrous Oxide	124-128	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	193-212
31336304-0	2019	The coupling interaction of NO2- with NH4+ or NO3- as an important source of N2O emission from agricultural soil in the North China Plain.	Nitrous Oxide	77-80	NBL1, DAN family BMP antagonist	Homo sapiens	46-49
31336304-4	2019	The results showed that the N2O average fluxes from the complex treatments of NO2- + NO3- were 1.4-2.4 times the sum of those from the separate treatments of NO2- and NO3- whereas from the complex treatments of NO2- + NH4+ were a factor of 1-1.4 larger than those from the separate treatments of NO2- and NH4+, indicating the coupling interaction of NO2- with NH4+ or NO3- makes a remarkable contribution to N2O emission from the soil.	Nitrous Oxide	28-31	NBL1, DAN family BMP antagonist	Homo sapiens	85-88
31336304-4	2019	The results showed that the N2O average fluxes from the complex treatments of NO2- + NO3- were 1.4-2.4 times the sum of those from the separate treatments of NO2- and NO3- whereas from the complex treatments of NO2- + NH4+ were a factor of 1-1.4 larger than those from the separate treatments of NO2- and NH4+, indicating the coupling interaction of NO2- with NH4+ or NO3- makes a remarkable contribution to N2O emission from the soil.	Nitrous Oxide	28-31	NBL1, DAN family BMP antagonist	Homo sapiens	167-170
31336304-4	2019	The results showed that the N2O average fluxes from the complex treatments of NO2- + NO3- were 1.4-2.4 times the sum of those from the separate treatments of NO2- and NO3- whereas from the complex treatments of NO2- + NH4+ were a factor of 1-1.4 larger than those from the separate treatments of NO2- and NH4+, indicating the coupling interaction of NO2- with NH4+ or NO3- makes a remarkable contribution to N2O emission from the soil.	Nitrous Oxide	28-31	NBL1, DAN family BMP antagonist	Homo sapiens	167-170
31336304-4	2019	The results showed that the N2O average fluxes from the complex treatments of NO2- + NO3- were 1.4-2.4 times the sum of those from the separate treatments of NO2- and NO3- whereas from the complex treatments of NO2- + NH4+ were a factor of 1-1.4 larger than those from the separate treatments of NO2- and NH4+, indicating the coupling interaction of NO2- with NH4+ or NO3- makes a remarkable contribution to N2O emission from the soil.	Nitrous Oxide	408-411	NBL1, DAN family BMP antagonist	Homo sapiens	85-88
31336304-6	2019	As the intermediate product of nitrification and denitrification, NO2- produced is also expected to interact with NH4+ or NO3- to promote N2O emission from the soil, especially during fertilization events when NO2- is easily accumulated due to the acceleration of the nitrification and denitrification processes.	Nitrous Oxide	138-141	NBL1, DAN family BMP antagonist	Homo sapiens	122-125
31539948-10	2019	For the total cumulative N2O (crop cycle + fallow), the N2O emissions from NT1 and CT1 were not different, but 10x higher than those from the respective crops without N fertilization.	Nitrous Oxide	56-59	catalase isozyme 1	Zea mays	83-86
31539948-11	2019	To the emissions per unit of grain yield, CT1 and NT1 emitted 769 and 391 mg N2O kg-1 grain produced, respectively, and NT1 was most efficient in fertilizer-into-product conversion.	Nitrous Oxide	77-80	catalase isozyme 1	Zea mays	42-45
31251996-4	2019	However, we have shown that nitrous oxide, another NMDAR blocking anesthetic and a putative rapid-acting antidepressant, evokes TrkB-GSK3beta signaling alterations during rebound slow EEG (electroencephalogram) oscillations.	Nitrous Oxide	28-41	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	51-56
31517481-6	2019	We hypothesized that supplying N2O vs. NO3- would enhance the dominance of distinct N2O-reducing bacteria.	Nitrous Oxide	84-87	NBL1, DAN family BMP antagonist	Homo sapiens	39-42
31412465-8	2019	Heavy NO3- and COD loading reduced nitrification and increased the relative contribution of denitrification to N2O in winter.	Nitrous Oxide	111-114	NBL1, DAN family BMP antagonist	Homo sapiens	6-9
31465213-5	2019	Our results showed that the form of the N inputs dominated the effects of eCO2 on N2O emissions: eCO2 significantly increased N2O emissions with NO3--N inputs but had no effect with NH4+-N inputs.	Nitrous Oxide	82-85	NBL1, DAN family BMP antagonist	Homo sapiens	145-148
31465213-5	2019	Our results showed that the form of the N inputs dominated the effects of eCO2 on N2O emissions: eCO2 significantly increased N2O emissions with NO3--N inputs but had no effect with NH4+-N inputs.	Nitrous Oxide	126-129	NBL1, DAN family BMP antagonist	Homo sapiens	145-148
31465213-8	2019	Further, eCO2 enhancement of N2O emissions under NO3--N inputs concurred with a shift in the soil denitrifier community composition in favor of N2O-producing (nirK- and nirS-type) over N2O-consuming (nosZ-type) denitrifiers.	Nitrous Oxide	29-32	NBL1, DAN family BMP antagonist	Homo sapiens	49-52
31465213-9	2019	Together, these results indicate that eCO2 stimulated N2O emissions mainly through altering plant N preference in favor of NH4+ over NO3- and thus stimulating soil denitrifiers and their activities.	Nitrous Oxide	54-57	NBL1, DAN family BMP antagonist	Homo sapiens	133-136
31251996-4	2019	However, we have shown that nitrous oxide, another NMDAR blocking anesthetic and a putative rapid-acting antidepressant, evokes TrkB-GSK3beta signaling alterations during rebound slow EEG (electroencephalogram) oscillations.	Nitrous Oxide	28-41	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	128-132
31251996-4	2019	However, we have shown that nitrous oxide, another NMDAR blocking anesthetic and a putative rapid-acting antidepressant, evokes TrkB-GSK3beta signaling alterations during rebound slow EEG (electroencephalogram) oscillations.	Nitrous Oxide	28-41	glycogen synthase kinase 3 beta	Mus musculus	133-141
31408040-0	2019	Dr. Frank A. Shattuck"s Unfolding "Specialty, the Administration of Nitrous Oxide Gas".	Nitrous Oxide	68-81	gastrin	Homo sapiens	82-86
31181534-6	2019	In both streams, CH4 emissions were generally higher in summer-fall and negatively correlated with flow and NO3- concentration while N2O emissions were generally higher in winter/spring and positively correlated with flow and NO3-.	Nitrous Oxide	133-136	NBL1, DAN family BMP antagonist	Homo sapiens	226-229
30542936-10	2019	Additionally, before sleep nNO was also positively associated with IL-6 (r = 0.586, p = 0.005) and IL-8 (r = 0.520, p = 0.016) concentration.	Nitrous Oxide	27-30	interleukin 6	Homo sapiens	67-71
30542936-10	2019	Additionally, before sleep nNO was also positively associated with IL-6 (r = 0.586, p = 0.005) and IL-8 (r = 0.520, p = 0.016) concentration.	Nitrous Oxide	27-30	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
31854678-12	2019	Compared with the control, the reduction rates of N2O in the BW-40, BW30, BW20, and BW10 were 70.13%, 68.26%, 50.83%, and 37.90%, respectively, and the ratios of N2O emissions to the removed nitrogen in CWs with biochar were significantly lower than those in the CW without biochar.	Nitrous Oxide	50-53	BW30	Homo sapiens	68-72
31598438-0	2019	Nitrous Oxide-induced B12 Deficiency Presenting With Myeloneuropathy.	Nitrous Oxide	0-13	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	22-25
31598438-2	2019	This is a case of a 27-year-old female exotic dancer who presented with clinical and laboratory manifestations of subacute combined degeneration of the spinal cord secondary to nitrous oxide-induced B12 deficiency from chronic whippets consumption.	Nitrous Oxide	177-190	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	199-202
31854678-12	2019	Compared with the control, the reduction rates of N2O in the BW-40, BW30, BW20, and BW10 were 70.13%, 68.26%, 50.83%, and 37.90%, respectively, and the ratios of N2O emissions to the removed nitrogen in CWs with biochar were significantly lower than those in the CW without biochar.	Nitrous Oxide	50-53	BW20	Homo sapiens	74-78
31854678-12	2019	Compared with the control, the reduction rates of N2O in the BW-40, BW30, BW20, and BW10 were 70.13%, 68.26%, 50.83%, and 37.90%, respectively, and the ratios of N2O emissions to the removed nitrogen in CWs with biochar were significantly lower than those in the CW without biochar.	Nitrous Oxide	50-53	BW10	Homo sapiens	84-88
30928528-0	2019	Considering the plug-flow behavior of the gas phase in nitrifying BAF models significantly improves the prediction of N2O emissions.	Nitrous Oxide	118-121	BAF nuclear assembly factor 1	Homo sapiens	66-69
30288695-7	2019	Immediate-early genes (e.g., bdnf) and phosphorylation of mitogen-activated protein kinase-markers of neuronal excitability-were upregulated during N2O exposure.	Nitrous Oxide	148-151	jun proto-oncogene	Mus musculus	0-15
30288695-7	2019	Immediate-early genes (e.g., bdnf) and phosphorylation of mitogen-activated protein kinase-markers of neuronal excitability-were upregulated during N2O exposure.	Nitrous Oxide	148-151	brain derived neurotrophic factor	Mus musculus	29-33
30288695-8	2019	Notably, phosphorylation of BDNF receptor TrkB and GSK3beta (glycogen synthase kinase 3beta) became regulated only gradually upon N2O discontinuation, during a brain state dominated by slow EEG activity.	Nitrous Oxide	130-133	brain derived neurotrophic factor	Mus musculus	28-32
30288695-8	2019	Notably, phosphorylation of BDNF receptor TrkB and GSK3beta (glycogen synthase kinase 3beta) became regulated only gradually upon N2O discontinuation, during a brain state dominated by slow EEG activity.	Nitrous Oxide	130-133	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	42-46
30288695-8	2019	Notably, phosphorylation of BDNF receptor TrkB and GSK3beta (glycogen synthase kinase 3beta) became regulated only gradually upon N2O discontinuation, during a brain state dominated by slow EEG activity.	Nitrous Oxide	130-133	glycogen synthase kinase 3 beta	Mus musculus	51-59
30288695-8	2019	Notably, phosphorylation of BDNF receptor TrkB and GSK3beta (glycogen synthase kinase 3beta) became regulated only gradually upon N2O discontinuation, during a brain state dominated by slow EEG activity.	Nitrous Oxide	130-133	glycogen synthase kinase 3 beta	Mus musculus	61-91
30928528-4	2019	In this work, a tertiary nitrifying BAF model including the main N2O biological pathways was developed and confronted to full-scale data from Seine Aval, the largest wastewater resource recovery facility in Europe.	Nitrous Oxide	65-68	BAF nuclear assembly factor 1	Homo sapiens	36-39
30628357-14	2019	Annual N2O emissions from the CK, NPK, and NPKM treatments were 0.21 kg hm-2, 2.32 kg hm-2, and 2.15 kg hm-2, respectively, with a non-significant difference between the NPK and NPKM treatments (P=0.74).	Nitrous Oxide	7-10	Putative anthocyanidin reductase	Zea mays	72-76
31121917-5	2019	At the GR6 (SiH4:N2O = 30:5), the MIS capacitor exhibited the widest memory window; the flat band voltage (DeltaVFB) shifts of 4.45 V was obtained at the sweep voltage of +-11 V for 10 s, and it was expected to maintain ~71% of the initial value after 10 years.	Nitrous Oxide	17-20	long intergenic non-protein coding RNA 1565	Homo sapiens	7-10
30920211-4	2019	Although the calculated adsorption energy of CO is exceedingly higher than N2O for our studied systems, the adsorbed CO could react with the surface oxygen atom of the PTA support through the MvK mechanism to form an oxygen vacancy on the PTA surface.	Nitrous Oxide	75-78	pre T cell antigen receptor alpha	Homo sapiens	168-171
30920211-5	2019	N2O acts as an oxygen donor to replenish the PTA support and release N2 in the whole reaction process.	Nitrous Oxide	0-3	pre T cell antigen receptor alpha	Homo sapiens	45-48
31087940-4	2019	The results showed that the dissolved N2O concentration in the agricultural headwater stream ranged from 0.26 to 1.28 mug L-1 with an annual mean value of 0.57 mug L-1, with nitrate (NO3--N, with an annual mean concentration of 1.45 mg L-1) as the predominant reactive N form.	Nitrous Oxide	38-41	L1 cell adhesion molecule	Homo sapiens	122-125
31087940-4	2019	The results showed that the dissolved N2O concentration in the agricultural headwater stream ranged from 0.26 to 1.28 mug L-1 with an annual mean value of 0.57 mug L-1, with nitrate (NO3--N, with an annual mean concentration of 1.45 mg L-1) as the predominant reactive N form.	Nitrous Oxide	38-41	L1 cell adhesion molecule	Homo sapiens	164-167
31087940-4	2019	The results showed that the dissolved N2O concentration in the agricultural headwater stream ranged from 0.26 to 1.28 mug L-1 with an annual mean value of 0.57 mug L-1, with nitrate (NO3--N, with an annual mean concentration of 1.45 mg L-1) as the predominant reactive N form.	Nitrous Oxide	38-41	NBL1, DAN family BMP antagonist	Homo sapiens	183-186
31087940-4	2019	The results showed that the dissolved N2O concentration in the agricultural headwater stream ranged from 0.26 to 1.28 mug L-1 with an annual mean value of 0.57 mug L-1, with nitrate (NO3--N, with an annual mean concentration of 1.45 mg L-1) as the predominant reactive N form.	Nitrous Oxide	38-41	L1 cell adhesion molecule	Homo sapiens	164-167
31087940-5	2019	The seasonal mean concentrations of the dissolved N2O in winter, spring, summer, and autumn were 0.63, 0.45, 0.53, and 0.64 mug L-1, respectively, without significant seasonal variations.	Nitrous Oxide	50-53	L1 cell adhesion molecule	Homo sapiens	128-131
31087940-6	2019	The annual dynamics of the dissolved N2O concentration were primarily governed by the concentration of NO3--N in the stream water, with denitrification being the main process producing N2O.	Nitrous Oxide	37-40	NBL1, DAN family BMP antagonist	Homo sapiens	103-106
31087940-8	2019	The temporal variations in the saturation levels of the dissolved N2O were mainly controlled by the water temperature and the NO3--N concentration of the stream water.	Nitrous Oxide	66-69	NBL1, DAN family BMP antagonist	Homo sapiens	126-129
31087940-9	2019	During April-October, the concentration of dissolved N2O in the stream fluctuated obviously as a result of heavy rainfall, which resulted in an increase of the concentration of NO3-N in the stream water in the short term after the rain, which promoted denitrification and then increased the dissolved N2O level correspondingly.	Nitrous Oxide	53-56	NBL1, DAN family BMP antagonist	Homo sapiens	177-180
31087940-9	2019	During April-October, the concentration of dissolved N2O in the stream fluctuated obviously as a result of heavy rainfall, which resulted in an increase of the concentration of NO3-N in the stream water in the short term after the rain, which promoted denitrification and then increased the dissolved N2O level correspondingly.	Nitrous Oxide	301-304	NBL1, DAN family BMP antagonist	Homo sapiens	177-180
30628357-14	2019	Annual N2O emissions from the CK, NPK, and NPKM treatments were 0.21 kg hm-2, 2.32 kg hm-2, and 2.15 kg hm-2, respectively, with a non-significant difference between the NPK and NPKM treatments (P=0.74).	Nitrous Oxide	7-10	Putative anthocyanidin reductase	Zea mays	86-90
30628357-14	2019	Annual N2O emissions from the CK, NPK, and NPKM treatments were 0.21 kg hm-2, 2.32 kg hm-2, and 2.15 kg hm-2, respectively, with a non-significant difference between the NPK and NPKM treatments (P=0.74).	Nitrous Oxide	7-10	Putative anthocyanidin reductase	Zea mays	86-90
30306993-4	2018	It was found that the catalytic cycle for CO oxidation by N2O proceeds in three stages: N2O activation to form a (PNN)Ru-OH intermediate, CO insertion into the Ru-OH bond to form a (PNN)Ru-COOH intermediate and CO2 release from (PNN)Ru-COOH.	Nitrous Oxide	58-61	pinin, desmosome associated protein	Homo sapiens	114-117
30025239-5	2018	Dissolved N2 in the river water ranged from 337 to 513 mumol N2 L-1, and dissolved N2O ranged from 10.4 to 15.4 nmol N2O L-1.	Nitrous Oxide	83-86	L1 cell adhesion molecule	Homo sapiens	121-124
30408869-4	2018	In general, the N2O emission fluxes were positively correlated to nitrate (NO3-) concentrations in soil solution, supporting the important role of denitrification in N2O production, which was also modified by environmental factors such as soil temperature and moisture.	Nitrous Oxide	16-19	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
30628383-5	2018	The concentration and flux of N2O observed in NH4+-polluted rivers are significantly higher than that in the NO3--polluted and N-limited rivers.	Nitrous Oxide	30-33	NBL1, DAN family BMP antagonist	Homo sapiens	109-112
30306993-0	2018	Non-innocent PNN ligand is important for CO oxidation by N2O catalyzed by a (PNN)Ru-H pincer complex: insights from DFT calculations.	Nitrous Oxide	57-60	pinin, desmosome associated protein	Homo sapiens	13-16
30306993-4	2018	It was found that the catalytic cycle for CO oxidation by N2O proceeds in three stages: N2O activation to form a (PNN)Ru-OH intermediate, CO insertion into the Ru-OH bond to form a (PNN)Ru-COOH intermediate and CO2 release from (PNN)Ru-COOH.	Nitrous Oxide	58-61	pinin, desmosome associated protein	Homo sapiens	182-185
30306993-0	2018	Non-innocent PNN ligand is important for CO oxidation by N2O catalyzed by a (PNN)Ru-H pincer complex: insights from DFT calculations.	Nitrous Oxide	57-60	pinin, desmosome associated protein	Homo sapiens	77-80
30306993-2	2018	developed an efficient and mild method for CO oxidation by N2O to give CO2 and N2 catalyzed by a (PNN)Ru-H pincer complex.	Nitrous Oxide	59-62	pinin, desmosome associated protein	Homo sapiens	98-101
30306993-4	2018	It was found that the catalytic cycle for CO oxidation by N2O proceeds in three stages: N2O activation to form a (PNN)Ru-OH intermediate, CO insertion into the Ru-OH bond to form a (PNN)Ru-COOH intermediate and CO2 release from (PNN)Ru-COOH.	Nitrous Oxide	58-61	pinin, desmosome associated protein	Homo sapiens	182-185
30306993-4	2018	It was found that the catalytic cycle for CO oxidation by N2O proceeds in three stages: N2O activation to form a (PNN)Ru-OH intermediate, CO insertion into the Ru-OH bond to form a (PNN)Ru-COOH intermediate and CO2 release from (PNN)Ru-COOH.	Nitrous Oxide	88-91	pinin, desmosome associated protein	Homo sapiens	114-117
30306993-6	2018	The calculations demonstrated that the Ru-H bond of the catalyst plays an important role in facilitating the activation of N2O, which is the rate-determining step for the whole catalytic cycle, and the non-innocent PNN ligand is very important for CO oxidation by N2O.	Nitrous Oxide	123-126	pinin, desmosome associated protein	Homo sapiens	215-218
30306993-6	2018	The calculations demonstrated that the Ru-H bond of the catalyst plays an important role in facilitating the activation of N2O, which is the rate-determining step for the whole catalytic cycle, and the non-innocent PNN ligand is very important for CO oxidation by N2O.	Nitrous Oxide	264-267	pinin, desmosome associated protein	Homo sapiens	215-218
30408970-3	2018	We highlight the presence of isomers for the N2O-H2O complex with the help of theoretical calculations at second order Moller-Plesset (MP2) and coupled-cluster single double triple-F12a/aug-cc-pVTZ levels.	Nitrous Oxide	45-48	tryptase pseudogene 1	Homo sapiens	135-138
30554563-10	2018	Furthermore, human kallistatin protein suppressed tumor necrosis factor-alpha-induced NADPH oxidase activity and increased endothelial nitrous oxide synthase and sirtuin 1 expression in cultured human endothelial cells.	Nitrous Oxide	135-148	serpin family A member 4	Homo sapiens	19-30
30554563-10	2018	Furthermore, human kallistatin protein suppressed tumor necrosis factor-alpha-induced NADPH oxidase activity and increased endothelial nitrous oxide synthase and sirtuin 1 expression in cultured human endothelial cells.	Nitrous Oxide	135-148	tumor necrosis factor	Homo sapiens	50-77
30179453-2	2018	Here we describe an alternative analytical protocol to convert NO3- to N2O instead of NO before measurement.	Nitrous Oxide	71-74	NBL1, DAN family BMP antagonist	Homo sapiens	63-66
29569802-8	2018	The N2 O isotopic signature indicated that under eCO2 the sources of the additional emissions, 8,407 mug N2 O-N/m2 during the first 58 days after labelling, were associated with NO 3 -  reduction (+2.0%), NH 4 +  oxidation (+11.1%) and organic N oxidation (+86.9%).	Nitrous Oxide	4-8	NBL1, DAN family BMP antagonist	Homo sapiens	178-182
29569802-8	2018	The N2 O isotopic signature indicated that under eCO2 the sources of the additional emissions, 8,407 mug N2 O-N/m2 during the first 58 days after labelling, were associated with NO 3 -  reduction (+2.0%), NH 4 +  oxidation (+11.1%) and organic N oxidation (+86.9%).	Nitrous Oxide	105-109	NBL1, DAN family BMP antagonist	Homo sapiens	178-182
29960846-4	2018	Treatment of Hep3B with BPA increased the levels of nitrous oxide, a metabolite of nitric oxide and activated Nrf2 by nitrosylation of Keap1, leading to the induction of heme oxygenase-1 (HO-1) and UGT2B1 mRNAs.	Nitrous Oxide	52-65	kelch like ECH associated protein 1	Homo sapiens	135-140
29960846-4	2018	Treatment of Hep3B with BPA increased the levels of nitrous oxide, a metabolite of nitric oxide and activated Nrf2 by nitrosylation of Keap1, leading to the induction of heme oxygenase-1 (HO-1) and UGT2B1 mRNAs.	Nitrous Oxide	52-65	heme oxygenase 1	Homo sapiens	170-186
29525425-7	2018	PVP-Ag and Ag2S NPs had no effects on N2 release rates and the composition of denitrifiers, however, inhibited the emission of N2O (by reducing the abundance of nirK), suggesting that normal denitrification-induced N2 formation in sediments could still be sustained when the N2O production decrease lied within a certain range.	Nitrous Oxide	127-130	angiotensin II receptor type 1	Homo sapiens	11-15
29574362-11	2018	Stepwise regression analysis indicated that dissolved N2O were primarily influenced by NH4+ in agricultural rivers and by NO3- in rural rivers; while dissolved N2O in urban rivers was primarily predicted by temperature and reflected the integrated impact of sewage input and river hydrology.	Nitrous Oxide	54-57	NBL1, DAN family BMP antagonist	Homo sapiens	122-125
29574362-12	2018	Nitrate-N and NO3--O isotope data and linear regression of N2O and river water variables strongly indicated that dissolved N2O was mainly derived from nitrification in agricultural rivers and denitrification in rural and urban rivers.	Nitrous Oxide	123-126	NBL1, DAN family BMP antagonist	Homo sapiens	14-17
29272846-7	2018	Plots receiving fertilizer applications and those with high densities of livestock showed the highest N2O fluxes (1.6+-0.3kgN2O-Nha-1yr-1, n=7) followed by natural forests (1.1+-0.1kgN2O-Nha-1yr-1, n=6); although these were not significantly different (p=0.19).	Nitrous Oxide	102-105	solute carrier family 9 member B1	Homo sapiens	128-137
29812933-3	2018	Herein, we report an efficient CO oxidation by N2O catalyzed by a (PNN)Ru-H pincer complex under mild conditions, even with no added base.	Nitrous Oxide	47-50	pinin, desmosome associated protein	Homo sapiens	67-70
29330894-3	2018	For instance, the binuclear nonheme iron site of YtfE, a hemerythrin-like protein involved in the repair of iron centers in Escherichia coli, catalyzes the reduction of nitric oxide to nitrous oxide, and the human F-box/LRR-repeat protein 5, which contains a hemerythrin-like domain, is involved in intracellular iron homeostasis.	Nitrous Oxide	185-198	F-box and leucine rich repeat protein 5	Homo sapiens	214-240
29736261-2	2018	Patients with MTHFR mutations who also receive N2O during ophthalmic artery chemotherapy (OAC) for retinoblastoma may have a heightened thrombotic risk.	Nitrous Oxide	47-50	methylenetetrahydrofolate reductase	Homo sapiens	14-19
29736261-8	2018	Conclusions: Choroidal infarction in eyes treated with OAC developed in children who were both deficient in at least one working allele of the MTHFR gene (heterozygous or homozygous) and received N2O induction during OAC.	Nitrous Oxide	196-199	methylenetetrahydrofolate reductase	Homo sapiens	143-148
29520552-3	2018	BC has recently been shown to accelerate the emissions of N2O via the biotic ammonium oxidation pathway, which results in lower nitrogen use efficiency and environmentally harmful losses of NO3 and/ or N2O.	Nitrous Oxide	58-61	NBL1, DAN family BMP antagonist	Homo sapiens	190-193
29128121-6	2018	The accumulation of N2O is most likely due to nitrification (high concentrations of dissolved oxygen and NO3- and null concentrations of ammonium) and, to a lesser extent, initial denitrification in a few sampling locations (medium concentrations of dissolved oxygen and NO3-).	Nitrous Oxide	20-23	NBL1, DAN family BMP antagonist	Homo sapiens	105-108
29128121-6	2018	The accumulation of N2O is most likely due to nitrification (high concentrations of dissolved oxygen and NO3- and null concentrations of ammonium) and, to a lesser extent, initial denitrification in a few sampling locations (medium concentrations of dissolved oxygen and NO3-).	Nitrous Oxide	20-23	NBL1, DAN family BMP antagonist	Homo sapiens	271-274
29555906-3	2018	Here we find that N2O flux can be predicted by models incorporating soil nitrate concentration (NO3-), water content and temperature using a global field survey of N2O emissions and potential driving factors across a wide range of organic soils.	Nitrous Oxide	18-21	NBL1, DAN family BMP antagonist	Homo sapiens	96-99
29555906-4	2018	N2O emissions increase with NO3- and follow a bell-shaped distribution with water content.	Nitrous Oxide	0-3	NBL1, DAN family BMP antagonist	Homo sapiens	28-31
29555906-6	2018	Above 5 mg NO3--N kg-1, either draining wet soils or irrigating well-drained soils increases N2O emission by orders of magnitude.	Nitrous Oxide	93-96	NBL1, DAN family BMP antagonist	Homo sapiens	11-14
29555906-7	2018	As soil temperature together with NO3- explains 69% of N2O emission, tropical wetlands should be a priority for N2O management.	Nitrous Oxide	55-58	NBL1, DAN family BMP antagonist	Homo sapiens	34-37
29131928-8	2018	RESULTS: NO3- /NO2- nitrogen is routed to the 15 Nalpha position of N2 O in the azide reaction; hence the delta15 Nalpha value should be used for N2 O laser spectrometry results.	Nitrous Oxide	68-72	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
29719360-2	2018	Nitrous oxide mainly disturbs B12 metabolism and damages nerves, followed by apparent neuropsychiatric symptoms.	Nitrous Oxide	0-13	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	30-33
29131928-8	2018	RESULTS: NO3- /NO2- nitrogen is routed to the 15 Nalpha position of N2 O in the azide reaction; hence the delta15 Nalpha value should be used for N2 O laser spectrometry results.	Nitrous Oxide	146-150	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
29236023-3	2017	N2O production was 2.06 mg L-1 during the anoxic phase, with N2O emission during air pulses and the aeration phase of 1.6% of the nitrogen loading rate.	Nitrous Oxide	0-3	L1 cell adhesion molecule	Homo sapiens	27-30
31938112-0	2018	Nampt/RelB pathway protects learning and memory ability in aged rats after general anesthesia with sevoflurane and nitrous oxide.	Nitrous Oxide	115-128	nicotinamide phosphoribosyltransferase	Rattus norvegicus	0-5
31938112-0	2018	Nampt/RelB pathway protects learning and memory ability in aged rats after general anesthesia with sevoflurane and nitrous oxide.	Nitrous Oxide	115-128	RELB proto-oncogene, NF-kB subunit	Rattus norvegicus	6-10
29218634-2	2018	N2OR is the terminal reductase in a respiratory chain converting N2O to N2 in denitrifying bacteria; COX is the terminal oxidase of the aerobic respiratory chain of certain bacteria and eukaryotic organisms transforming O2 to H2O accompanied by proton pumping.	Nitrous Oxide	0-3	cytochrome c oxidase subunit 7A1	Bos taurus	101-104
29236023-5	2017	Conversely, the carbon supply shortage, under low C/N ratios, increased N2O emission (0.040 mgN2O-N L-1), due to incomplete denitrification.	Nitrous Oxide	72-75	L1 cell adhesion molecule	Homo sapiens	100-103
29236025-3	2017	Small amounts of nitrous oxide (N2O) up to 0.015 +- 0.004 kg m-3 d-1 at the ammonium concentration of 210 mg L-1 were produced in the CANON process and decreased with the decrease in the influent ammonium loads.	Nitrous Oxide	17-30	immunoglobulin kappa variable 1-16	Homo sapiens	109-112
29236025-3	2017	Small amounts of nitrous oxide (N2O) up to 0.015 +- 0.004 kg m-3 d-1 at the ammonium concentration of 210 mg L-1 were produced in the CANON process and decreased with the decrease in the influent ammonium loads.	Nitrous Oxide	32-35	immunoglobulin kappa variable 1-16	Homo sapiens	109-112
29303256-9	2018	Our preliminary results from the Styx Glacier ice core samples have the potential to define small N2O variations (a few parts per billion) at centennial time scales.	Nitrous Oxide	98-101	serine/threonine/tyrosine interacting protein	Homo sapiens	33-37
29964598-7	2017	Compared with CK, the N2O cumulative emissions from C1 and C2 were reduced by 45.3% and 31.6%, respectively, but C3, M1, and M2 increased by 17.3%, 37.4%, and 27.6%, respectively.	Nitrous Oxide	22-25	anthocyanin regulatory C1 protein	Zea mays	52-61
29236023-4	2017	Batch tests with AGS from the pilot reactor verified that at the greatest COD/N ratio (1.55), the N2O production (1.08 mgN2O-N L-1) and consumption (up to 0.05 mgN2O-N L-1), resulted in the lowest remaining dissolved N2O (0.03 mgN2O-N L-1), stripping the minimum N2O gas (0.018 mgN2O-N L-1).	Nitrous Oxide	98-101	L1 cell adhesion molecule	Homo sapiens	127-130
29236023-4	2017	Batch tests with AGS from the pilot reactor verified that at the greatest COD/N ratio (1.55), the N2O production (1.08 mgN2O-N L-1) and consumption (up to 0.05 mgN2O-N L-1), resulted in the lowest remaining dissolved N2O (0.03 mgN2O-N L-1), stripping the minimum N2O gas (0.018 mgN2O-N L-1).	Nitrous Oxide	98-101	L1 cell adhesion molecule	Homo sapiens	168-171
29236023-4	2017	Batch tests with AGS from the pilot reactor verified that at the greatest COD/N ratio (1.55), the N2O production (1.08 mgN2O-N L-1) and consumption (up to 0.05 mgN2O-N L-1), resulted in the lowest remaining dissolved N2O (0.03 mgN2O-N L-1), stripping the minimum N2O gas (0.018 mgN2O-N L-1).	Nitrous Oxide	98-101	L1 cell adhesion molecule	Homo sapiens	168-171
29236023-4	2017	Batch tests with AGS from the pilot reactor verified that at the greatest COD/N ratio (1.55), the N2O production (1.08 mgN2O-N L-1) and consumption (up to 0.05 mgN2O-N L-1), resulted in the lowest remaining dissolved N2O (0.03 mgN2O-N L-1), stripping the minimum N2O gas (0.018 mgN2O-N L-1).	Nitrous Oxide	98-101	L1 cell adhesion molecule	Homo sapiens	168-171
28811146-8	2017	At a low influent COD/NH4+-N ratio (2.7), the N2O conversion rate was greater when there were more biodegradable carbon substrates.	Nitrous Oxide	46-49	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	18-21
28811146-0	2017	N2O emissions from an intermittently aerated semi-aerobic aged refuse bioreactor: Combined effect of COD and NH4+-N in influent leachate.	Nitrous Oxide	0-3	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	101-104
29025172-7	2017	Several relapses of NNO occurred in patient 1 with persisting MOG-IgG in spite of immunsuppressive therapy.	Nitrous Oxide	20-23	myelin oligodendrocyte glycoprotein	Homo sapiens	62-65
28811146-1	2017	The carbon-nitrogen ratio (COD/NH4+-N) is an important factor affecting nitrification and denitrification in wastewater treatment; this factor also influences nitrous oxide (N2O) emissions.	Nitrous Oxide	159-172	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	27-30
28811146-1	2017	The carbon-nitrogen ratio (COD/NH4+-N) is an important factor affecting nitrification and denitrification in wastewater treatment; this factor also influences nitrous oxide (N2O) emissions.	Nitrous Oxide	174-177	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	27-30
28811146-4	2017	Experimental results showed that N2O emissions increased as the influent COD/NH4+-N decreased.	Nitrous Oxide	33-36	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	73-76
28811146-5	2017	The influent COD had a greater effect on N2O emissions than NH4+-N at the same influent ratios of COD/NH4+-N (2.7 and 8.0, respectively).	Nitrous Oxide	41-44	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	13-16
28811146-6	2017	The maximum N2O emission accounted for 8.82+-2.65% of the total nitrogen removed from the influent leachate; the maximum level occurred when the COD was 2000mg/L.	Nitrous Oxide	12-15	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	145-148
28809129-3	2017	Further perturbations to one carbon metabolism, such as reduced vitamin B12 levels via the use of nitrous oxide for sedation during childhood ALL treatment, may increase neurotoxicity risk.	Nitrous Oxide	98-111	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	72-75
28979255-4	2017	When incubated with NO3- and N2O at pH 6.0, transient accumulation of N2O was observed and no significant NH4+ production was observed.	Nitrous Oxide	70-73	NBL1, DAN family BMP antagonist	Homo sapiens	20-23
28749673-0	2017	A Nonheme, High-Spin {FeNO}8 Complex that Spontaneously Generates N2O.	Nitrous Oxide	66-69	spindlin 1	Homo sapiens	16-20
28749673-2	2017	Complex 3 is a rare example of a high-spin (S = 1) {FeNO}8 and is the first example, to our knowledge, of a mononuclear nonheme {FeNO}8 species that generates N2O.	Nitrous Oxide	159-162	spindlin 1	Homo sapiens	38-42
28288805-5	2017	Moreover, aligned with prior research showing a link between chronic air pollution and suppression of humoral immunity, the author of this commentary has proposed that environmental exposure to pervasive air pollutants, particularly nitrous oxide (N2O), may target several anti-inflammatory biomarkers, including alpha 7 nicotinic acetylcholine receptor (alpha7nAChR) inhibition and stimulation of kappa opioid receptor (KOR) activity.	Nitrous Oxide	233-246	opioid receptor kappa 1	Homo sapiens	398-419
28625444-12	2017	Factors associated with conversion from nitrous oxide to neuraxial blockade were labor induction (aRR=2.0, CI 1.2-3.3) and labor augmentation (aRR=1.7, CI 1.0-2.9).	Nitrous Oxide	40-53	arrestin beta 2	Homo sapiens	98-103
28625444-12	2017	Factors associated with conversion from nitrous oxide to neuraxial blockade were labor induction (aRR=2.0, CI 1.2-3.3) and labor augmentation (aRR=1.7, CI 1.0-2.9).	Nitrous Oxide	40-53	arrestin beta 1	Homo sapiens	143-148
28467048-4	2017	Adding N2O and N2 effluxes to catchment nitrogen output not only reduced the discrepancy between nitrogen inputs and outputs (9.9 kg ha-1 yr-1 and 6.5 or 6.3 kg ha-1 yr-1, respectively), but also between nitrogen outputs from two catchments with different topographies (6.5 kg ha-1 yr-1 for the catchment with a large wetland, 6.3 kg ha-1 yr-1 for the catchment with a very small wetland).	Nitrous Oxide	7-10	Rho GTPase activating protein 45	Homo sapiens	133-142
28467048-4	2017	Adding N2O and N2 effluxes to catchment nitrogen output not only reduced the discrepancy between nitrogen inputs and outputs (9.9 kg ha-1 yr-1 and 6.5 or 6.3 kg ha-1 yr-1, respectively), but also between nitrogen outputs from two catchments with different topographies (6.5 kg ha-1 yr-1 for the catchment with a large wetland, 6.3 kg ha-1 yr-1 for the catchment with a very small wetland).	Nitrous Oxide	7-10	Rho GTPase activating protein 45	Homo sapiens	161-170
28467048-4	2017	Adding N2O and N2 effluxes to catchment nitrogen output not only reduced the discrepancy between nitrogen inputs and outputs (9.9 kg ha-1 yr-1 and 6.5 or 6.3 kg ha-1 yr-1, respectively), but also between nitrogen outputs from two catchments with different topographies (6.5 kg ha-1 yr-1 for the catchment with a large wetland, 6.3 kg ha-1 yr-1 for the catchment with a very small wetland).	Nitrous Oxide	7-10	Rho GTPase activating protein 45	Homo sapiens	161-170
28467048-4	2017	Adding N2O and N2 effluxes to catchment nitrogen output not only reduced the discrepancy between nitrogen inputs and outputs (9.9 kg ha-1 yr-1 and 6.5 or 6.3 kg ha-1 yr-1, respectively), but also between nitrogen outputs from two catchments with different topographies (6.5 kg ha-1 yr-1 for the catchment with a large wetland, 6.3 kg ha-1 yr-1 for the catchment with a very small wetland).	Nitrous Oxide	7-10	Rho GTPase activating protein 45	Homo sapiens	161-170
28537019-4	2017	An increase in N2O flux was observed following floodwater disappearance after the addition of NH4+, with a corresponding increase in the concentrations of NO3- and dissolved N2O in the oxic and anoxic soil layers, respectively.	Nitrous Oxide	15-18	NBL1, DAN family BMP antagonist	Homo sapiens	155-158
28537019-6	2017	An additional anoxic soil slurry experiment demonstrated that the addition of NO3- induced the expression of nirK gene and caused a concomitant increase in N2O production.	Nitrous Oxide	156-159	NBL1, DAN family BMP antagonist	Homo sapiens	78-81
28537019-7	2017	These findings suggest that NO3- production in the oxic layers is important as it provides a substrate and induces the synthesis of denitrification enzymes in the anoxic layer during N2O production.	Nitrous Oxide	183-186	NBL1, DAN family BMP antagonist	Homo sapiens	28-31
28333392-5	2017	Based on experimental evidence and published literature, we hypothesize that when nitrate (NO3- ) is the main Nitrogen source and the intracellular concentration of NO2- is low (i.e. under physiological conditions), microalgal N2 O synthesis involves the reduction of NO3- to NO2- by NR followed by the reduction of NO2- to NO by the dual system involving NR.	Nitrous Oxide	227-231	uncharacterized protein	Chlamydomonas reinhardtii	284-286
28333392-5	2017	Based on experimental evidence and published literature, we hypothesize that when nitrate (NO3- ) is the main Nitrogen source and the intracellular concentration of NO2- is low (i.e. under physiological conditions), microalgal N2 O synthesis involves the reduction of NO3- to NO2- by NR followed by the reduction of NO2- to NO by the dual system involving NR.	Nitrous Oxide	227-231	uncharacterized protein	Chlamydomonas reinhardtii	356-358
32665782-7	2017	Multiple linear regressions including DOC : NO3 - and other variables (dissolved oxygen, DO; total dissolved nitrogen, TDN; and temperature) explained much of the statistical variation in nitrous oxide (N2O, r2 = 0.78), carbon dioxide (CO2, r2 = 0.78) and methane (CH4, r 2 = 0.50) saturation in stream water.	Nitrous Oxide	188-201	NBL1, DAN family BMP antagonist	Homo sapiens	44-47
28228237-9	2017	Denitrification of NO3- to N2 occurred in anaerobic conditions, while at intermediate dissolved oxygen; N2O was the dominant reaction product.	Nitrous Oxide	104-107	NBL1, DAN family BMP antagonist	Homo sapiens	19-22
29965116-3	2017	During the study period, cumulative N2O emissions in the sediment-water interface without vegetation (NV) and the ditch ecosystem with natural vegetation (V) were 0.07 and 0.43 kg hm-2, respectively.	Nitrous Oxide	36-39	Putative anthocyanidin reductase	Zea mays	180-184
28288805-5	2017	Moreover, aligned with prior research showing a link between chronic air pollution and suppression of humoral immunity, the author of this commentary has proposed that environmental exposure to pervasive air pollutants, particularly nitrous oxide (N2O), may target several anti-inflammatory biomarkers, including alpha 7 nicotinic acetylcholine receptor (alpha7nAChR) inhibition and stimulation of kappa opioid receptor (KOR) activity.	Nitrous Oxide	233-246	opioid receptor kappa 1	Homo sapiens	421-424
28288805-5	2017	Moreover, aligned with prior research showing a link between chronic air pollution and suppression of humoral immunity, the author of this commentary has proposed that environmental exposure to pervasive air pollutants, particularly nitrous oxide (N2O), may target several anti-inflammatory biomarkers, including alpha 7 nicotinic acetylcholine receptor (alpha7nAChR) inhibition and stimulation of kappa opioid receptor (KOR) activity.	Nitrous Oxide	248-251	opioid receptor kappa 1	Homo sapiens	398-419
28288805-5	2017	Moreover, aligned with prior research showing a link between chronic air pollution and suppression of humoral immunity, the author of this commentary has proposed that environmental exposure to pervasive air pollutants, particularly nitrous oxide (N2O), may target several anti-inflammatory biomarkers, including alpha 7 nicotinic acetylcholine receptor (alpha7nAChR) inhibition and stimulation of kappa opioid receptor (KOR) activity.	Nitrous Oxide	248-251	opioid receptor kappa 1	Homo sapiens	421-424
28075565-12	2017	Measurements by in situ infrared spectroscopy show that N2O is formed in sp3-C-H acetoxylation reactions at 80  C. Studies confirm that cyclopalladated NO2 complexes are rapidly oxidized to the corresponding NO3 adducts on exposure to NO2(g).	Nitrous Oxide	56-59	NBL1, DAN family BMP antagonist	Homo sapiens	208-211
27596480-2	2017	The influence of NO3- concentration on N2 O production during this process was also evaluated.	Nitrous Oxide	39-43	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
27596480-4	2017	N2 O production rates correlated with NO3- concentration in the liquid phase, with a 10-fold increase in N2 O production as NO3- concentration increased from 50 to 200 g m-3 .	Nitrous Oxide	0-4	NBL1, DAN family BMP antagonist	Homo sapiens	38-41
27596480-4	2017	N2 O production rates correlated with NO3- concentration in the liquid phase, with a 10-fold increase in N2 O production as NO3- concentration increased from 50 to 200 g m-3 .	Nitrous Oxide	0-4	NBL1, DAN family BMP antagonist	Homo sapiens	124-127
27596480-4	2017	N2 O production rates correlated with NO3- concentration in the liquid phase, with a 10-fold increase in N2 O production as NO3- concentration increased from 50 to 200 g m-3 .	Nitrous Oxide	105-109	NBL1, DAN family BMP antagonist	Homo sapiens	124-127
27596480-7	2017	This study confirmed (i) the feasibility of co-oxidising CH4 and H2 S with denitrification, as well as (ii) the critical need to control NO3- concentration to minimize N2 O production by anoxic denitrifiers.	Nitrous Oxide	168-172	NBL1, DAN family BMP antagonist	Homo sapiens	137-140
28166085-1	2017	: Here we describe a case of subacute combined spinal cord degeneration caused by nitrous oxide (N2O, laughing gas) use.	Nitrous Oxide	82-95	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	111-114
28166085-3	2017	Unfortunately, the use of N2O leads to inactivation of vitamin B12.	Nitrous Oxide	26-29	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	63-66
28448607-5	2017	The results showed that current annual N2O emissions followed a skewed distribution with a mean and median values of 2.27 and 1.71 kg N ha-1 yr-1, respectively.	Nitrous Oxide	39-42	solute carrier family 9 member B1	Homo sapiens	134-145
28079226-3	2017	Computationally predicted products of RDX hydrolysis such as nitrite, nitrous oxide, formaldehyde, formate, and ammonia correspond to experimentally observed ones.	Nitrous Oxide	70-83	radixin	Homo sapiens	38-41
27753120-7	2017	High-sensitive CRP and nNO reflected responses best (52% had increased CRP levels at 2-3 days; 66% had decreased nNO levels).	Nitrous Oxide	23-26	C-reactive protein	Homo sapiens	71-74
29192578-3	2017	Nitrous oxide is known to cause subacute degeneration of the spinal cord by inactivation of active vitamin B12.	Nitrous Oxide	0-13	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	107-110
27959492-0	2017	Can Reduction of NO to N2O in Cytochrome c Dependent Nitric Oxide Reductase Proceed through a Trans-Mechanism?	Nitrous Oxide	23-26	cytochrome c, somatic	Homo sapiens	30-42
27997197-5	2017	Interestingly, the lone pair containing substituents (-NMe2, -Cl,) facilitates disilene   silylene dissociation; on the contrary it reduces the electrophilicity at Si center in silylene, a feature manifested with higher activation barrier during N2O attack.	Nitrous Oxide	246-249	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	55-59
27965392-0	2016	Is there a pathway for N2O production from hydroxylamine oxidoreductase in ammonia-oxidizing bacteria?	Nitrous Oxide	23-26	thioredoxin reductase 1	Homo sapiens	57-71
27699705-5	2016	Parameters included the maximum specific reduction rates, [Formula: see text], growth rates, [Formula: see text], and yields, Y, for reduction of NO3- (nitrate) to nitrite (NO2-), NO2- to N2O, and N2O to N2, with acetate as the electron donor.	Nitrous Oxide	197-200	NBL1, DAN family BMP antagonist	Homo sapiens	146-149
27605461-3	2016	METHODS: The ammonium nitrate (NH4 NO3 ) decomposition technique provides a strategy to scale the 15 N site-specific (SP   delta15 Nalpha - delta15 Nbeta ) and bulk (delta15 Nbulk  = (delta15 Nalpha  + delta15 Nbeta )/2) isotopic composition of N2 O against the international standard for the 15 N/14 N isotope ratio (AIR-N2 ).	Nitrous Oxide	245-249	NBL1, DAN family BMP antagonist	Homo sapiens	35-38
27605461-5	2016	RESULTS: The validity of the NH4 NO3 decomposition technique to link NH4+ and NO3- moiety-specific delta15 N analysis by IRMS to the site-specific nitrogen isotopic composition of N2 O was confirmed.	Nitrous Oxide	180-184	NBL1, DAN family BMP antagonist	Homo sapiens	33-36
27605461-5	2016	RESULTS: The validity of the NH4 NO3 decomposition technique to link NH4+ and NO3- moiety-specific delta15 N analysis by IRMS to the site-specific nitrogen isotopic composition of N2 O was confirmed.	Nitrous Oxide	180-184	NBL1, DAN family BMP antagonist	Homo sapiens	78-81
27605461-7	2016	CONCLUSIONS: The study reveals that the completeness and reproducibility of the NH4 NO3 decomposition reaction currently confine the anchoring of N2 O site-specific isotopic composition to the international isotope ratio scale AIR-N2 .	Nitrous Oxide	146-150	NBL1, DAN family BMP antagonist	Homo sapiens	84-87
27699705-8	2016	When N2O and NO3- were added concurrently, the apparent (extant) kinetics, [Formula: see text], assuming reduction to N2, were 6.3 gCOD gCOD-1 d-1, compared to 5.4 gCOD gCOD-1 d-1 for NO3- as the sole added acceptor.	Nitrous Oxide	5-8	NBL1, DAN family BMP antagonist	Homo sapiens	184-187
27956679-3	2016	We also explored whether methylenetetrahydrofolate reductase gene polymorphisms (1298A&gt;C, 667C&gt;T) would enhance nitrous oxide analgesia.	Nitrous Oxide	118-131	methylenetetrahydrofolate reductase	Homo sapiens	25-60
27659182-6	2016	We also present a brief case study supporting out hypothesis that nitrous oxide contributes to methotrexate neurotoxicity and a nutritional study, showing that vitamin B12 deficiency is common in pediatric leukemia patients.	Nitrous Oxide	66-79	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	168-171
26926711-6	2016	N2O is thought to target the opioidergic system, including the K-opioid receptor (KOR).	Nitrous Oxide	0-3	opioid receptor kappa 1	Homo sapiens	63-80
26926711-6	2016	N2O is thought to target the opioidergic system, including the K-opioid receptor (KOR).	Nitrous Oxide	0-3	opioid receptor kappa 1	Homo sapiens	82-85
26569075-0	2016	Laughing Gas in a Pediatric Emergency Department-Fun for All Participants: Vitamin B12 Status Among Medical Staff Working With Nitrous Oxide.	Nitrous Oxide	127-140	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	83-86
26569075-2	2016	Evaluation of the vitamin B12 levels in anesthetic staff applying nitrous oxide showed reduced vitamin B12 plasma levels.	Nitrous Oxide	66-79	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	26-29
26569075-2	2016	Evaluation of the vitamin B12 levels in anesthetic staff applying nitrous oxide showed reduced vitamin B12 plasma levels.	Nitrous Oxide	66-79	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	103-106
26569075-3	2016	This study examines the vitamin B12 status of medical staff working with nitrous oxide in a pediatric emergency department (ED).	Nitrous Oxide	73-86	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	32-35
26569075-10	2016	CONCLUSIONS: The use of nitrous oxide (50%-70%) with a demand valve is safe for the vitamin B12 status of medical personnel in the ED.	Nitrous Oxide	24-37	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	92-95
27959349-4	2016	Nitrous oxide is known to inactivate vitamin B12 via oxidation, which can precipitate a demyelinating myelopathy akin to the classical B12 deficiency syndrome, subacute combined degeneration of the spinal cord.	Nitrous Oxide	0-13	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	45-48
27170579-3	2016	Riverine N2 O flux was significantly correlated with NH4 , NO3 and DIN (NH4  + NO3 ) concentrations, loads and yields.	Nitrous Oxide	9-13	NBL1, DAN family BMP antagonist	Homo sapiens	59-62
27170579-3	2016	Riverine N2 O flux was significantly correlated with NH4 , NO3 and DIN (NH4  + NO3 ) concentrations, loads and yields.	Nitrous Oxide	9-13	NBL1, DAN family BMP antagonist	Homo sapiens	79-82
27593275-3	2016	The aim of this study was therefore to assess how maximum potential denitrification and N2O production rates, and the relationship between the two (relative N2O production), is controlled by availability of nitrate (NO3(-)), carbon (C), phosphorus (P), and temperature.	Nitrous Oxide	88-91	NBL1, DAN family BMP antagonist	Homo sapiens	216-219
26865057-1	2016	Struvite crystallization (SCP) is combined with a nitrification inhibitor (dicyandiamide, DCD) to mitigate the NH3 and N2O emission during composting.	Nitrous Oxide	119-122	urocortin 3	Homo sapiens	26-29
26865057-1	2016	Struvite crystallization (SCP) is combined with a nitrification inhibitor (dicyandiamide, DCD) to mitigate the NH3 and N2O emission during composting.	Nitrous Oxide	119-122	dermcidin	Homo sapiens	90-93
26865057-5	2016	The DCD significantly inhibits nitrification when the content was higher than 50mgkg(-1), and that could reduce the N2O emission by 76.1-77.6%.	Nitrous Oxide	116-119	dermcidin	Homo sapiens	4-7
27593275-3	2016	The aim of this study was therefore to assess how maximum potential denitrification and N2O production rates, and the relationship between the two (relative N2O production), is controlled by availability of nitrate (NO3(-)), carbon (C), phosphorus (P), and temperature.	Nitrous Oxide	157-160	NBL1, DAN family BMP antagonist	Homo sapiens	216-219
27593275-5	2016	Maximum potential denitrification and N2O production rates at 4 C were reached already at NO3(-) additions of 106-120mug NO3(-)-N/L, and remained unchanged with higher NO3 amendments.	Nitrous Oxide	38-41	NBL1, DAN family BMP antagonist	Homo sapiens	90-93
27593275-5	2016	Maximum potential denitrification and N2O production rates at 4 C were reached already at NO3(-) additions of 106-120mug NO3(-)-N/L, and remained unchanged with higher NO3 amendments.	Nitrous Oxide	38-41	NBL1, DAN family BMP antagonist	Homo sapiens	121-124
27593275-5	2016	Maximum potential denitrification and N2O production rates at 4 C were reached already at NO3(-) additions of 106-120mug NO3(-)-N/L, and remained unchanged with higher NO3 amendments.	Nitrous Oxide	38-41	NBL1, DAN family BMP antagonist	Homo sapiens	121-124
27593275-8	2016	Combined, our results suggests that unproductive northern boreal lakes currently have low potential for denitrification but are susceptible to small changes in NO3 loading especially if these are accompanied by enhanced C and P availability, likely promoting higher N2O production relative to N2.	Nitrous Oxide	266-269	NBL1, DAN family BMP antagonist	Homo sapiens	160-163
27139304-5	2016	In the absence of methanol injection failure and with an influent BOD/NO3-N ratio higher than 3, average reduction of N2O was estimated to be of 93%.	Nitrous Oxide	118-121	NBL1, DAN family BMP antagonist	Homo sapiens	70-73
26841777-10	2016	We propose that aerobic methane oxidation coupled to denitrification and perchlorate reduction (AMO-D and AMO-PR) directly oxidized methane and reduced NO3 (-) to NO2 (-) or N2O under anoxic condition, producing organic matter for methanol-assimilating denitrification and perchlorate reduction (MA-D and MA-PR) to reduce NO3 (-).	Nitrous Oxide	174-177	NBL1, DAN family BMP antagonist	Homo sapiens	152-155
27285951-6	2016	Exposure to N2O is thought to exert its antinociceptive properties by stimulating release of dynorphin peptides in the central nervous system which act upon kappa opioid receptors (KOR).	Nitrous Oxide	12-15	opioid receptor kappa 1	Homo sapiens	157-179
27285951-6	2016	Exposure to N2O is thought to exert its antinociceptive properties by stimulating release of dynorphin peptides in the central nervous system which act upon kappa opioid receptors (KOR).	Nitrous Oxide	12-15	opioid receptor kappa 1	Homo sapiens	181-184
27285951-8	2016	Interestingly, constitutive activity of the KOR receptor in rat brain has been recently shown to undergo maturational alterations, suggesting that while altered gait profiles in ADHD may be a function of the enhanced opioidergic activity attributable to chronic exposure to the environmental air pollutant, N2O, age-attenuated constitutive activity of KOR in brain may explain the normalization of these altered gait profiles in older ADHD subjects.	Nitrous Oxide	307-310	opioid receptor kappa 1	Homo sapiens	44-47
27126572-6	2016	A TIVA technique was performed, and a nitrous oxide inhaler was prepared in case of a possible increase in PVR during the reperfusion period.	Nitrous Oxide	38-51	PVR cell adhesion molecule	Homo sapiens	107-110
27101460-5	2016	Renovation of grassland increased N2O flux to a maximum of 0.9kgN2O-Nha(-1) from poorly-drained soil over four days after treatment.	Nitrous Oxide	34-37	solute carrier family 9 member B1	Homo sapiens	68-74
27130561-5	2016	Such a procedure is illustrated here, for the reduction of nitric oxide (NO) to nitrous oxide and water in the membrane enzyme, cytochrome c dependent nitric oxide reductase (cNOR).	Nitrous Oxide	80-93	cytochrome c, somatic	Homo sapiens	128-140
26969694-3	2016	Microcosms established with soils from two representative U.S. Midwest agricultural regions produced N2O from added NO3 (-) or NO2 (-) in the presence of antibiotics to inhibit bacteria.	Nitrous Oxide	101-104	NBL1, DAN family BMP antagonist	Homo sapiens	116-119
26841777-10	2016	We propose that aerobic methane oxidation coupled to denitrification and perchlorate reduction (AMO-D and AMO-PR) directly oxidized methane and reduced NO3 (-) to NO2 (-) or N2O under anoxic condition, producing organic matter for methanol-assimilating denitrification and perchlorate reduction (MA-D and MA-PR) to reduce NO3 (-).	Nitrous Oxide	174-177	NBL1, DAN family BMP antagonist	Homo sapiens	322-325
26647444-5	2016	nNO (30 nL min(-1) cut-off) had good sensitivity and specificity (91% and 96%, respectively).	Nitrous Oxide	0-3	CD59 molecule (CD59 blood group)	Homo sapiens	11-17
29732769-2	2016	Results showed that the N2O production of restoration wetland soils (R2002 and R2007) with NO3--N addition was much higher than that with NH4+-N addition, but both NH4+-N and NO3--N additions demonstrated inhibition on the N2O production of soils in R0.	Nitrous Oxide	24-27	NBL1, DAN family BMP antagonist	Homo sapiens	91-94
29732769-3	2016	Although the effect of NO3--N addition on the total N2O production of topsoil in R2002 was significantly higher than those in R2007, the values in R2002 and R2007 were greatly increased with increasing NO3--N addition.	Nitrous Oxide	52-55	NBL1, DAN family BMP antagonist	Homo sapiens	23-26
29732769-6	2016	In R0 and R2002 soils, the N2O produced by non-biological processes was generally eleva-ted with NH4+-N addition, while with NO3--N addition, the non-biological processes generating N2O in R0, R2002 and R2007 soils were generally inhibited, which was closely correlated with the regulation of soil pH caused by the import of exogenous nitrogen.	Nitrous Oxide	27-30	NBL1, DAN family BMP antagonist	Homo sapiens	125-128
29732769-6	2016	In R0 and R2002 soils, the N2O produced by non-biological processes was generally eleva-ted with NH4+-N addition, while with NO3--N addition, the non-biological processes generating N2O in R0, R2002 and R2007 soils were generally inhibited, which was closely correlated with the regulation of soil pH caused by the import of exogenous nitrogen.	Nitrous Oxide	182-185	NBL1, DAN family BMP antagonist	Homo sapiens	125-128
29732769-7	2016	This study found that the enrichment of NO3--N greatly enhanced the total N2O production of wetland soils and significantly altered the original contribution patterns of biological and non-biological processes to N2O production.	Nitrous Oxide	74-77	NBL1, DAN family BMP antagonist	Homo sapiens	40-43
29732769-7	2016	This study found that the enrichment of NO3--N greatly enhanced the total N2O production of wetland soils and significantly altered the original contribution patterns of biological and non-biological processes to N2O production.	Nitrous Oxide	213-216	NBL1, DAN family BMP antagonist	Homo sapiens	40-43
29732769-8	2016	Thus, special attention should be paid on the influences of nutrient import (particularly NO3--N enrichment) induced by ecological restoration project on N2O production of wetland soils.	Nitrous Oxide	154-157	NBL1, DAN family BMP antagonist	Homo sapiens	90-93
26979688-2	2016	The charge carriers in these ions are NNO2(-) and O(-) for (N2O)(n)O(-) clusters with a solvation induced core ion switch, and N2O(-) for (N2O)n(-) clusters.	Nitrous Oxide	60-63	membrane frizzled-related protein	Homo sapiens	38-58
26605044-2	2015	In this nitrogen removal process, a complete biological denitrification from nitrate (NO3 (-)) to molecular nitrogen (N2) was achieved by four reduction steps, forming nitrite (NO2 (-)), nitric oxide (NO) and nitrous oxide (N2O) as intermediate compounds.	Nitrous Oxide	209-222	NBL1, DAN family BMP antagonist	Homo sapiens	86-89
26567165-0	2015	Retraction note to: Isotopic analysis of N and O in NO3- by selective bacterial reduction to N2O for groundwater pollution.	Nitrous Oxide	93-96	NBL1, DAN family BMP antagonist	Homo sapiens	52-55
26605044-2	2015	In this nitrogen removal process, a complete biological denitrification from nitrate (NO3 (-)) to molecular nitrogen (N2) was achieved by four reduction steps, forming nitrite (NO2 (-)), nitric oxide (NO) and nitrous oxide (N2O) as intermediate compounds.	Nitrous Oxide	224-227	NBL1, DAN family BMP antagonist	Homo sapiens	86-89
25752934-7	2015	We estimate that a doubling of current median NO3 (-) concentrations would increase the global estuary water-air N2 O flux by about 0.45 Tg N2 O-N yr(-1) or about 190%.	Nitrous Oxide	113-117	NBL1, DAN family BMP antagonist	Homo sapiens	46-49
26489675-3	2015	In this case, we discuss the interaction of nitrous oxide with the enzymatic pathways involved in the biochemistry of vitamin B12.	Nitrous Oxide	44-57	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	126-129
25911044-7	2015	Computational results are in a good agreement with experimental data on hydrolysis of RDX, suggesting that 4-nitro-2,4-diazabutanal, nitrite, formaldehyde, and nitrous oxide are main products for early stages of RDX decomposition under alkaline conditions.	Nitrous Oxide	160-173	radixin	Homo sapiens	86-89
26557879-4	2015	Its acetylation of cyclooxygenase 2 (COX-2) in platelets leads to the blockade of pro-inflammatory chemicals and generation of anti-inflammatory mediators and increase in nitrous oxide (NO) production, which helps to preserve arterial endothelium.	Nitrous Oxide	171-184	prostaglandin-endoperoxide synthase 2	Homo sapiens	19-35
26557879-4	2015	Its acetylation of cyclooxygenase 2 (COX-2) in platelets leads to the blockade of pro-inflammatory chemicals and generation of anti-inflammatory mediators and increase in nitrous oxide (NO) production, which helps to preserve arterial endothelium.	Nitrous Oxide	171-184	prostaglandin-endoperoxide synthase 2	Homo sapiens	37-42
26284318-3	2015	Treatment of 2 with N2O yielded the dinuclear four-coordinate silicon(IV) complex 11 with an SiN3O skeleton and a central four-membered Si2O2 ring.	Nitrous Oxide	20-23	SIN3 transcription regulator family member A	Homo sapiens	93-97
26343381-0	2015	Nitrous oxide directly inhibits action potential-dependent neurotransmission from single presynaptic boutons adhering to rat hippocampal CA3 neurons.	Nitrous Oxide	0-13	carbonic anhydrase 3	Rattus norvegicus	137-140
26151723-2	2015	The headspace N2O was manually injected into an OA-ICOS isotopic N2O laser analyzer through a syringe septum port.	Nitrous Oxide	14-17	inducible T cell costimulator	Homo sapiens	51-55
26129708-0	2015	Spin-inversion and spin-selection in the reactions FeO(+) + H2 and Fe(+) + N2O.	Nitrous Oxide	75-78	spindlin 1	Homo sapiens	0-4
26129708-0	2015	Spin-inversion and spin-selection in the reactions FeO(+) + H2 and Fe(+) + N2O.	Nitrous Oxide	75-78	spindlin 1	Homo sapiens	19-23
26179972-6	2015	This is the first study to correlate the dynamics of soil slNH3, NO2(-), N2O and nitrifier genes, and the first to show how ASC can regulate NO2(-) levels and N2O production.	Nitrous Oxide	159-162	apoptosis-associated speck-like protein containing a CARD	Bos taurus	124-127
26601391-4	2015	Therefore, this paper retrieves nitrous oxide profiles from the AIRS data with an Optimal Estimate Method for the first time in China.	Nitrous Oxide	32-45	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	64-68
26601391-0	2015	[Simulation of Atmospheric Nitrous Oxide Profiles Retrieval from AIRS Observations].	Nitrous Oxide	27-40	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	65-69
25368340-2	2015	Studies have shown that N2O alters the function of the N-methyl-d-aspartate (NMDA), GABAA, opioid, and serotonin receptors among others.	Nitrous Oxide	24-27	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	84-89
25694837-11	2015	Furthermore, our case emphasizes that patients with vitamin B12 deficiency should be assessed for nitrous oxide abuse.	Nitrous Oxide	98-111	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	60-63
25735905-6	2015	VT EPR spectroscopy shows a transient signal corresponding to a triplet state between 20 and 60 K. Complex 2 reacts with PPh3 to generate [Pd(NNO(ISQ))(PPh3)](+) and one equivalent of [PdCl(NNO(ISQ))].	Nitrous Oxide	142-145	protein phosphatase 4 catalytic subunit	Homo sapiens	121-125
25735905-6	2015	VT EPR spectroscopy shows a transient signal corresponding to a triplet state between 20 and 60 K. Complex 2 reacts with PPh3 to generate [Pd(NNO(ISQ))(PPh3)](+) and one equivalent of [PdCl(NNO(ISQ))].	Nitrous Oxide	142-145	protein phosphatase 4 catalytic subunit	Homo sapiens	152-156
25273518-4	2015	Results showed the highest N2O emission (10.1 mg kg(-1) over 21 days) from the soil at pH 3.71 with 1000 mg kg(-1) NO3 (-) addition.	Nitrous Oxide	27-30	NBL1, DAN family BMP antagonist	Homo sapiens	115-118
24972544-7	2014	The nNO values of sea level and high altitude were compared to investigate the effect of high altitude on nNO levels.	Nitrous Oxide	4-7	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	18-21
25086587-8	2014	The N2O-induced increase in c-Fos-immunopositive cells in laminae III-IV of the lumbar spinal cord was significant in wild-type (WT), but not in KOP-KO mice.	Nitrous Oxide	4-7	FBJ osteosarcoma oncogene	Mus musculus	28-33
25351391-0	2014	Isotopic analysis of N and O in NO3- by selective bacterial reduction to N2O for groundwater pollution.	Nitrous Oxide	73-76	NBL1, DAN family BMP antagonist	Homo sapiens	32-35
24936269-0	2014	The Effect of Vitamin B12 Infusion on Prevention of Nitrous Oxide-induced Homocysteine Increase: A Double-blind Randomized Controlled Trial.	Nitrous Oxide	52-65	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	22-25
24979669-5	2014	Stoichiometric oxygen atom transfer from N2O to PPh3 was mediated by (IMes)Cu-FeCp(CO)2, indicating the presence of an N2O-activated intermediate that can be intercepted by exogenous reagents.	Nitrous Oxide	41-44	caveolin 1	Homo sapiens	48-52
24979669-5	2014	Stoichiometric oxygen atom transfer from N2O to PPh3 was mediated by (IMes)Cu-FeCp(CO)2, indicating the presence of an N2O-activated intermediate that can be intercepted by exogenous reagents.	Nitrous Oxide	119-122	caveolin 1	Homo sapiens	48-52
25163127-6	2014	Additionally, N2O uptake was most responsive to dissolved inorganic nitrogen with phosphorus (DIN + DIP) addition, suggesting that the N2O consumption process may be P limited.	Nitrous Oxide	14-17	DIP	Homo sapiens	100-103
25163127-6	2014	Additionally, N2O uptake was most responsive to dissolved inorganic nitrogen with phosphorus (DIN + DIP) addition, suggesting that the N2O consumption process may be P limited.	Nitrous Oxide	135-138	DIP	Homo sapiens	100-103
23985745-7	2014	Significant correlations were observed between N-cycling genes (ureC, gdh and amoA) and nitrous oxide flux, suggesting that they contributed to community metabolism.	Nitrous Oxide	88-101	glutamate dehydrogenase 1	Homo sapiens	70-73
24377428-8	2014	The molecular analysis revealed significant effects of N2O and xenon administration on c-fos and MMP-9 expression.	Nitrous Oxide	55-58	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	87-92
24377428-8	2014	The molecular analysis revealed significant effects of N2O and xenon administration on c-fos and MMP-9 expression.	Nitrous Oxide	55-58	matrix metallopeptidase 9	Rattus norvegicus	97-102
24410177-4	2014	We apply recursive partitioning analysis to examine the relationships between N2O flux and NO3-, dissolved oxygen (DO), temperature, land use and surficial geology in the Grand River, Canada, a seventh-order river in an agricultural catchment with substantial urban population.	Nitrous Oxide	78-81	NBL1, DAN family BMP antagonist	Homo sapiens	91-94
24410177-7	2014	This work indicates that a linear relationship between NO3- and N2O is unlikely to exist in most agricultural and urban impacted river systems.	Nitrous Oxide	64-67	NBL1, DAN family BMP antagonist	Homo sapiens	55-58
24145706-4	2013	Notably, the levels of interleukin (IL)-1beta, IL-8 and monocyte chemotactic protein-1 (MCP-1) in the ELF were significantly increased following the operations which involved the inhalation of sevoflurane and nitrous oxide, although the levels of these molecules were not significantly changed by the inhalation of sevoflurane and air.	Nitrous Oxide	209-222	C-C motif chemokine ligand 2	Homo sapiens	56-86
24202912-7	2014	TRPA1 activation by NNO-ABBH1 is suppressed by specific cysteine mutations but not by NO scavenging, suggesting that cysteine transnitrosylation underlies the activation of TRPA1 by NNO-ABBH1.	Nitrous Oxide	20-23	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
24202912-7	2014	TRPA1 activation by NNO-ABBH1 is suppressed by specific cysteine mutations but not by NO scavenging, suggesting that cysteine transnitrosylation underlies the activation of TRPA1 by NNO-ABBH1.	Nitrous Oxide	20-23	transient receptor potential cation channel subfamily A member 1	Homo sapiens	173-178
24202912-7	2014	TRPA1 activation by NNO-ABBH1 is suppressed by specific cysteine mutations but not by NO scavenging, suggesting that cysteine transnitrosylation underlies the activation of TRPA1 by NNO-ABBH1.	Nitrous Oxide	182-185	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
24202912-7	2014	TRPA1 activation by NNO-ABBH1 is suppressed by specific cysteine mutations but not by NO scavenging, suggesting that cysteine transnitrosylation underlies the activation of TRPA1 by NNO-ABBH1.	Nitrous Oxide	182-185	transient receptor potential cation channel subfamily A member 1	Homo sapiens	173-178
24145706-4	2013	Notably, the levels of interleukin (IL)-1beta, IL-8 and monocyte chemotactic protein-1 (MCP-1) in the ELF were significantly increased following the operations which involved the inhalation of sevoflurane and nitrous oxide, although the levels of these molecules were not significantly changed by the inhalation of sevoflurane and air.	Nitrous Oxide	209-222	C-C motif chemokine ligand 2	Homo sapiens	88-93
24639829-0	2014	The effects of nitrous oxide on vascular endothelial growth factor (VEGF) and its soluble receptor 1 (VEGFR1) in patient undergoing urological surgery.	Nitrous Oxide	15-28	vascular endothelial growth factor A	Homo sapiens	32-66
24639829-0	2014	The effects of nitrous oxide on vascular endothelial growth factor (VEGF) and its soluble receptor 1 (VEGFR1) in patient undergoing urological surgery.	Nitrous Oxide	15-28	vascular endothelial growth factor A	Homo sapiens	68-72
24639829-0	2014	The effects of nitrous oxide on vascular endothelial growth factor (VEGF) and its soluble receptor 1 (VEGFR1) in patient undergoing urological surgery.	Nitrous Oxide	15-28	fms related receptor tyrosine kinase 1	Homo sapiens	102-108
24639829-3	2014	OBJECTIVE of the study was to investigate the effect of nitrous oxide on VEGF and VEGFR1 levels in patients undergoing surgery.	Nitrous Oxide	56-69	vascular endothelial growth factor A	Homo sapiens	73-77
24639829-3	2014	OBJECTIVE of the study was to investigate the effect of nitrous oxide on VEGF and VEGFR1 levels in patients undergoing surgery.	Nitrous Oxide	56-69	fms related receptor tyrosine kinase 1	Homo sapiens	82-88
22918033-5	2013	Therefore, in this mini review, we focus on the recent research investigating the effects of commonly used anesthetics including isoflurane, sevoflurane, desflurane, nitrous oxide, and propofol, on Abeta accumulation in vitro and in vivo.	Nitrous Oxide	166-179	amyloid beta precursor protein	Homo sapiens	198-203
24145706-6	2013	These observations suggest that the combination of sevoflurane and nitrous oxide induces an inflammatory response (increased production of IL-1beta, IL-8 and MCP-1) and suppresses the anti-inflammatory response (reduced production of IL-12p70) in the local milieu of the airway.	Nitrous Oxide	67-80	interleukin 1 beta	Homo sapiens	139-147
24145706-6	2013	These observations suggest that the combination of sevoflurane and nitrous oxide induces an inflammatory response (increased production of IL-1beta, IL-8 and MCP-1) and suppresses the anti-inflammatory response (reduced production of IL-12p70) in the local milieu of the airway.	Nitrous Oxide	67-80	C-X-C motif chemokine ligand 8	Homo sapiens	149-153
24145706-6	2013	These observations suggest that the combination of sevoflurane and nitrous oxide induces an inflammatory response (increased production of IL-1beta, IL-8 and MCP-1) and suppresses the anti-inflammatory response (reduced production of IL-12p70) in the local milieu of the airway.	Nitrous Oxide	67-80	C-C motif chemokine ligand 2	Homo sapiens	158-163
24260214-0	2013	Impaired spatial learning and memory after sevoflurane-nitrous oxide anesthesia in aged rats is associated with down-regulated cAMP/CREB signaling.	Nitrous Oxide	55-68	cAMP responsive element binding protein 1	Rattus norvegicus	132-136
24044616-0	2013	Comment on "Modeling nitrous oxide production during biological nitrogen removal via nitrification and denitrification: extensions to the general asm models".	Nitrous Oxide	21-34	H19 imprinted maternally expressed transcript	Homo sapiens	146-149
24617051-5	2013	The N2O conversion ratio of r-A/ A/O process was the lowest among the three WWTP, which were 10.9% and 18.6% lower than that of A-A/A/O process and A+OD process, respectively.	Nitrous Oxide	4-7	amine oxidase copper containing 2	Homo sapiens	28-36
24044636-0	2013	Reply to comment on "Modeling nitrous oxide production during biological nitrogen removal via nitrification and denitrification: extensions to the general asm models".	Nitrous Oxide	30-43	H19 imprinted maternally expressed transcript	Homo sapiens	155-158
23760542-5	2013	N2O/O2 inhalation (Livopan ) was used during 46 procedures with indications including fractional RF/wrinkle reduction, IPL/rosacea, q-sw. laser/tattoos and hemosiderosis as well as fractional Er:Glass laser for scars and hypopigmentation.	Nitrous Oxide	0-3	pleckstrin homology like domain family A member 2	Homo sapiens	119-122
23947756-0	2013	Theoretical views on activation of methane catalyzed by Hf2+ and oxidation of CO (x(1)Sigma(+)) by N2O (x(1)Sigma(+)) Catalyzed by HfO2+ and TaO2+.	Nitrous Oxide	99-102	TAO kinase 2	Homo sapiens	141-145
23708866-9	2013	However, 2 minimum alveolar concentration isoflurane + nitrous oxide reduced neurokinin 1 receptor internalization (27 +- 3%; P &lt; 0.05; n = 5).	Nitrous Oxide	55-68	tachykinin receptor 1	Rattus norvegicus	77-98
23708866-10	2013	All agents reduced c-Fos expression (control: 34 +- 4, fentanyl: 8 +- 2, isoflurane: 12 +- 3, nitrous oxide: 11 +- 2, isoflurane + nitrous oxide: 12 +- 1, pentobarbital: 11 +- 2, propofol: 13 +- 3; P &lt; 0.05; n = 3).	Nitrous Oxide	131-144	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	19-24
23743421-3	2013	Kinetic analysis suggested two-step kinetics involving chemical equilibrium between S(2-), NO and SNO as step 1 and the slow conversion from SNO to N2O as step 2.	Nitrous Oxide	148-151	strawberry notch homolog 1	Homo sapiens	98-101
23743421-3	2013	Kinetic analysis suggested two-step kinetics involving chemical equilibrium between S(2-), NO and SNO as step 1 and the slow conversion from SNO to N2O as step 2.	Nitrous Oxide	148-151	strawberry notch homolog 1	Homo sapiens	141-144
23474488-1	2013	We tested the effects of insulin on production of nitrous oxide (NO)-related substances (nitrites and nitrates [NOx]) after (15)N-arginine intravenous infusion and on asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) concentrations in conditions reportedly associated with altered NO availability, i.e., aging, hypertension, hypercholesterolemia, and type 2 diabetes mellitus (T2DM).	Nitrous Oxide	50-63	insulin	Homo sapiens	25-32
23856660-1	2013	BACKGROUND: Nitrous oxide causes an acute increase in plasma homocysteine that is more pronounced in patients with the methylenetetrahydrofolate reductase (MTHFR) C677T or A1298C gene variant.	Nitrous Oxide	12-25	methylenetetrahydrofolate reductase	Homo sapiens	119-154
23856660-1	2013	BACKGROUND: Nitrous oxide causes an acute increase in plasma homocysteine that is more pronounced in patients with the methylenetetrahydrofolate reductase (MTHFR) C677T or A1298C gene variant.	Nitrous Oxide	12-25	methylenetetrahydrofolate reductase	Homo sapiens	156-161
23856660-2	2013	In this randomized controlled trial, the authors sought to determine whether patients carrying the MTHFR C677T or A1298C variant had a higher risk for perioperative cardiac events after nitrous oxide anesthesia and whether this risk could be mitigated by B-vitamins.	Nitrous Oxide	186-199	methylenetetrahydrofolate reductase	Homo sapiens	99-104
23898268-0	2013	Recreational nitrous oxide abuse-induced vitamin B12 deficiency in a patient presenting with hyperpigmentation of the skin.	Nitrous Oxide	13-26	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	49-52
23898268-2	2013	Although vitamin B12 deficiency rarely occurs in well-nourished, healthy, young people, nitrous oxide (N2O) intoxication is an important cause of vitamin B12 deficiency in this cohort.	Nitrous Oxide	88-101	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	154-157
23898268-2	2013	Although vitamin B12 deficiency rarely occurs in well-nourished, healthy, young people, nitrous oxide (N2O) intoxication is an important cause of vitamin B12 deficiency in this cohort.	Nitrous Oxide	103-106	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	154-157
23898268-5	2013	N2O intoxication-induced vitamin B12 deficiency was diagnosed based on the skin pigmentation that had manifested over the dorsa of her fingers, toes, and trunk, coupled with myeloneuropathy of the posterior and lateral columns, a low serum vitamin B12 level, an elevated serum homocysteine level, and the N2O exposure revealed while establishing the patient"s history.	Nitrous Oxide	0-3	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	33-36
23898268-5	2013	N2O intoxication-induced vitamin B12 deficiency was diagnosed based on the skin pigmentation that had manifested over the dorsa of her fingers, toes, and trunk, coupled with myeloneuropathy of the posterior and lateral columns, a low serum vitamin B12 level, an elevated serum homocysteine level, and the N2O exposure revealed while establishing the patient"s history.	Nitrous Oxide	0-3	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	248-251
23898268-5	2013	N2O intoxication-induced vitamin B12 deficiency was diagnosed based on the skin pigmentation that had manifested over the dorsa of her fingers, toes, and trunk, coupled with myeloneuropathy of the posterior and lateral columns, a low serum vitamin B12 level, an elevated serum homocysteine level, and the N2O exposure revealed while establishing the patient"s history.	Nitrous Oxide	305-308	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	33-36
23898268-7	2013	We recommend that dermatologists consider N2O intoxication-induced vitamin B12 deficiency as a potential cause of skin hyperpigmentation and myeloneuropathy of the posterior and lateral columns in young, otherwise healthy patients.	Nitrous Oxide	42-45	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	75-78
23871247-1	2013	AIM: To investigate the effects of the nitrous oxide (NO)-donor sodium nitroprusside (SNP) on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human gastric cancer cells.	Nitrous Oxide	39-52	TNF superfamily member 10	Homo sapiens	94-149
23871247-1	2013	AIM: To investigate the effects of the nitrous oxide (NO)-donor sodium nitroprusside (SNP) on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human gastric cancer cells.	Nitrous Oxide	39-52	TNF superfamily member 10	Homo sapiens	151-156
23480257-8	2013	Flooding with NO3- increased denitrification rate, net N2 O production and heterotrophic respiration, but a reduction in net CH4 production suggests inhibition of methanogenesis by NO3- or N2 O produced from denitrification.	Nitrous Oxide	55-59	NBL1, DAN family BMP antagonist	Homo sapiens	14-17
23536322-11	2013	NaK-Ni7-Ale2 proved to be efficient for the electrocatalytic reduction of nitrate, nitrite and nitrous oxide.	Nitrous Oxide	95-108	TANK binding kinase 1	Homo sapiens	0-3
23480257-8	2013	Flooding with NO3- increased denitrification rate, net N2 O production and heterotrophic respiration, but a reduction in net CH4 production suggests inhibition of methanogenesis by NO3- or N2 O produced from denitrification.	Nitrous Oxide	189-193	NBL1, DAN family BMP antagonist	Homo sapiens	14-17
23480257-9	2013	Implications for management and policy are that warming and flood events may promote microbial interactions in soil between distinct microbial communities and increase denitrification of excess NO3- with N2 O production contributing to no more than 50% of increases in total GHG production.	Nitrous Oxide	204-208	NBL1, DAN family BMP antagonist	Homo sapiens	194-197
23123346-0	2013	Increased brain monoaminergic tone after the NMDA receptor GluN2A subunit gene knockout is responsible for resistance to the hypnotic effect of nitrous oxide.	Nitrous Oxide	144-157	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	59-65
23388058-7	2013	In this latter instance, N-NO(2) homolysisis becomes the dominant decomposition channel on the ground electronic state, as found for HMX and RDX.	Nitrous Oxide	25-29	radixin	Homo sapiens	141-144
23123346-2	2013	Here, to clarify the role of NMDA receptors in anesthetic-induced unconsciousness, we examined the hypnotic properties of isoflurane, sevoflurane and nitrous oxide in NMDA receptor GluN2A subunit knockout mice.	Nitrous Oxide	150-163	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	181-187
23123346-6	2013	Knockout mice have enhanced brain monoaminergic activity which occurs secondary to NMDA receptor dysfunction, and the observed resistance to the isoflurane LORR ED(50)-sparing effect of nitrous oxide could be abolished by pretreatment with the dopamine D(2) receptor antagonist droperidol or with the serotonin 5-HT(2A) receptor antagonist ketanserin.	Nitrous Oxide	186-199	dopamine receptor D2	Mus musculus	244-266
22584536-1	2012	BACKGROUND: Nitrous oxide converts vitamin B12 to its nonmetabolically active form, inhibits methionine synthase, and results in an elevation of plasma total homocysteine (tHcy).	Nitrous Oxide	12-25	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	93-112
22606955-8	2012	The primary photoproducts from tert-butyl nitrite can also react to form acetone and nitrosomethane, but the absence of HNO prohibits the formation of N(2)O that was observed for the primary alkyl nitrites.	Nitrous Oxide	151-156	telomerase reverse transcriptase	Homo sapiens	31-35
22103938-5	2011	Biochemical alterations, in terms of homocysteine accumulation, demonstrated that intracellular methionine synthase had been inactivated by N(2)O absorbed by the cells, a process that also occurs in vivo.	Nitrous Oxide	140-145	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	96-115
22137658-0	2012	Isoflurane/nitrous oxide anesthesia induces increases in NMDA receptor subunit NR2B protein expression in the aged rat brain.	Nitrous Oxide	11-24	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	79-83
21952256-6	2011	METHODS: The authors performed molecular modeling of nitrous oxide binding on tPA, characterized the concentration-dependent effects of nitrous oxide on tPA enzymatic and thrombolytic activity in vitro, and investigated the effects of intraischemic and postischemic nitrous oxide in a rat model of thromboembolic acute ischemic stroke.	Nitrous Oxide	136-149	plasminogen activator, tissue type	Rattus norvegicus	153-156
21952256-6	2011	METHODS: The authors performed molecular modeling of nitrous oxide binding on tPA, characterized the concentration-dependent effects of nitrous oxide on tPA enzymatic and thrombolytic activity in vitro, and investigated the effects of intraischemic and postischemic nitrous oxide in a rat model of thromboembolic acute ischemic stroke.	Nitrous Oxide	136-149	plasminogen activator, tissue type	Rattus norvegicus	153-156
21952256-7	2011	RESULTS: The authors demonstrate nitrous oxide is a tPA inhibitor, intraischemic nitrous oxide dose-dependently inhibits tPA-induced thrombolysis and subsequent reduction of ischemic brain damage, and postischemic nitrous oxide reduces ischemic brain damage, but in contrast with xenon, it increases brain hemorrhages and disruption of the blood-brain barrier.	Nitrous Oxide	33-46	plasminogen activator, tissue type	Rattus norvegicus	52-55
21952256-7	2011	RESULTS: The authors demonstrate nitrous oxide is a tPA inhibitor, intraischemic nitrous oxide dose-dependently inhibits tPA-induced thrombolysis and subsequent reduction of ischemic brain damage, and postischemic nitrous oxide reduces ischemic brain damage, but in contrast with xenon, it increases brain hemorrhages and disruption of the blood-brain barrier.	Nitrous Oxide	33-46	plasminogen activator, tissue type	Rattus norvegicus	121-124
21952256-7	2011	RESULTS: The authors demonstrate nitrous oxide is a tPA inhibitor, intraischemic nitrous oxide dose-dependently inhibits tPA-induced thrombolysis and subsequent reduction of ischemic brain damage, and postischemic nitrous oxide reduces ischemic brain damage, but in contrast with xenon, it increases brain hemorrhages and disruption of the blood-brain barrier.	Nitrous Oxide	81-94	plasminogen activator, tissue type	Rattus norvegicus	52-55
21952256-7	2011	RESULTS: The authors demonstrate nitrous oxide is a tPA inhibitor, intraischemic nitrous oxide dose-dependently inhibits tPA-induced thrombolysis and subsequent reduction of ischemic brain damage, and postischemic nitrous oxide reduces ischemic brain damage, but in contrast with xenon, it increases brain hemorrhages and disruption of the blood-brain barrier.	Nitrous Oxide	81-94	plasminogen activator, tissue type	Rattus norvegicus	121-124
21952256-7	2011	RESULTS: The authors demonstrate nitrous oxide is a tPA inhibitor, intraischemic nitrous oxide dose-dependently inhibits tPA-induced thrombolysis and subsequent reduction of ischemic brain damage, and postischemic nitrous oxide reduces ischemic brain damage, but in contrast with xenon, it increases brain hemorrhages and disruption of the blood-brain barrier.	Nitrous Oxide	81-94	plasminogen activator, tissue type	Rattus norvegicus	52-55
21952256-7	2011	RESULTS: The authors demonstrate nitrous oxide is a tPA inhibitor, intraischemic nitrous oxide dose-dependently inhibits tPA-induced thrombolysis and subsequent reduction of ischemic brain damage, and postischemic nitrous oxide reduces ischemic brain damage, but in contrast with xenon, it increases brain hemorrhages and disruption of the blood-brain barrier.	Nitrous Oxide	81-94	plasminogen activator, tissue type	Rattus norvegicus	121-124
21938745-3	2011	The structures of these complexes are formed by a TTF-salphen(2-) ligand coordinated to the 3d metal ions in the inert tetradentate N(2)O(2) site.	Nitrous Oxide	132-137	ras homolog family member H	Homo sapiens	50-53
22113072-0	2012	Effect of PHB and oxygen uptake rate on nitrous oxide emission during simultaneous nitrification denitrification process.	Nitrous Oxide	40-53	prohibitin 1	Homo sapiens	10-13
22113072-6	2012	At the aerobic stage of SND, the simultaneous denitrification could carried out using PHB as the carbon source and N(2)O emission increased because of the slow degradation of PHB.	Nitrous Oxide	115-120	prohibitin 1	Homo sapiens	175-178
22309677-8	2012	RESULTS: The levels of CC16 correlated with nNO levels (r2 = 0.37; p = 0.02) in allergic subjects.The levels of both biomarkers showed inverse relationships with MC occurrence, as higher levels of CC16 (p = 0.03) and nNO (p = 0.05) were found in allergic subjects with no demonstrable MC compared to the levels in subjects with demonstrable MC.	Nitrous Oxide	44-47	secretoglobin family 1A member 1	Homo sapiens	23-27
22309677-8	2012	RESULTS: The levels of CC16 correlated with nNO levels (r2 = 0.37; p = 0.02) in allergic subjects.The levels of both biomarkers showed inverse relationships with MC occurrence, as higher levels of CC16 (p = 0.03) and nNO (p = 0.05) were found in allergic subjects with no demonstrable MC compared to the levels in subjects with demonstrable MC.	Nitrous Oxide	217-220	secretoglobin family 1A member 1	Homo sapiens	23-27
22309677-8	2012	RESULTS: The levels of CC16 correlated with nNO levels (r2 = 0.37; p = 0.02) in allergic subjects.The levels of both biomarkers showed inverse relationships with MC occurrence, as higher levels of CC16 (p = 0.03) and nNO (p = 0.05) were found in allergic subjects with no demonstrable MC compared to the levels in subjects with demonstrable MC.	Nitrous Oxide	217-220	secretoglobin family 1A member 1	Homo sapiens	197-201
22309677-9	2012	Similar relationships, but not reaching significance, were observed between the CC16 and nNO levels and Eos occurrence.	Nitrous Oxide	89-92	secretoglobin family 1A member 1	Homo sapiens	80-84
22309677-11	2012	CONCLUSIONS: The correlation between nasal CC16 and nNO levels in patients with allergic rhinitis, along with an inverse relationship between their levels and the occurrences of MC in allergic inflammation, may indicate that both biomarkers have anti-inflammatory effects by suppression of cell recruitment.	Nitrous Oxide	52-55	secretoglobin family 1A member 1	Homo sapiens	43-47
22685485-9	2012	The results showed that lipopolysaccharide/interferon-gamma (LPS/INF-gamma) increased nitrous oxide (NO) production inR AW264.7macrophages, whereas N(G)-nitro-L-argininemethyl ester (L-NAME) and CLG curtailed it.	Nitrous Oxide	86-99	interferon gamma	Homo sapiens	43-59
21952256-6	2011	METHODS: The authors performed molecular modeling of nitrous oxide binding on tPA, characterized the concentration-dependent effects of nitrous oxide on tPA enzymatic and thrombolytic activity in vitro, and investigated the effects of intraischemic and postischemic nitrous oxide in a rat model of thromboembolic acute ischemic stroke.	Nitrous Oxide	53-66	plasminogen activator, tissue type	Rattus norvegicus	78-81
21869515-7	2011	Modeled N2O fluxes (16-30 mug m(-2) h(-1)) from five sites were strongly related to river NO3-N concentrations ( r2 = 0.86).	Nitrous Oxide	8-11	NBL1, DAN family BMP antagonist	Homo sapiens	90-93
21680854-1	2011	BACKGROUND: Nitrous oxide inactivates vitamin B(12), inhibits methionine synthase, and consequently increases plasma total homocysteine (tHcy).	Nitrous Oxide	12-25	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	62-81
21815623-6	2011	Assuming that the extinction coefficient of the radicals is the same as that in the aqueous solution, the yields of the radicals per 100 eV are 0.29 and 0.48 for the Br(2)( -) radical in CTAB and CPB containing microemulsions (W(0) = 40), respectively, under N(2)O saturated conditions.	Nitrous Oxide	259-264	carboxypeptidase B1	Homo sapiens	196-199
21708249-9	2011	However, neuronal damage was apparent when N(2)O was combined with ISO as indicated by increased numbers of caspase-3-, Silver staining- and Fluoro-Jade C-positive cells in the frontal cortex, temporal gyrus and hippocampus.	Nitrous Oxide	43-48	caspase 3	Homo sapiens	108-117
21480653-2	2011	One of the N-NO(2) moieties of the RDX molecule was considered to be an active site.	Nitrous Oxide	11-15	radixin	Homo sapiens	35-38
21340676-4	2011	In this study, a slightly modified ASM1 model was implemented in the GPS-X software to simulate the concentration of such intermediate products (NO2-, NO and N2O) and to estimate the amounts of gaseous N2O emitted by the denitrification stage (12 biofilters) of the Seine-Centre WWTP (SIAAP, Paris).	Nitrous Oxide	158-161	H19 imprinted maternally expressed transcript	Homo sapiens	35-39
21340676-4	2011	In this study, a slightly modified ASM1 model was implemented in the GPS-X software to simulate the concentration of such intermediate products (NO2-, NO and N2O) and to estimate the amounts of gaseous N2O emitted by the denitrification stage (12 biofilters) of the Seine-Centre WWTP (SIAAP, Paris).	Nitrous Oxide	202-205	H19 imprinted maternally expressed transcript	Homo sapiens	35-39
21590821-5	2011	Although N(2)O(3) formation might be readily explained by the reaction Hb-Fe(3+)+NO(2)(-)+NO Hb-Fe(2+)+N(2)O(3), the exact manner in which methemoglobin (Hb-Fe(3+)), nitrite and NO interact with one another is unclear.	Nitrous Oxide	9-14	hemoglobin subunit gamma 2	Homo sapiens	139-152
21598938-4	2011	The calculated results show that the first step of pyrolysis is the rupture of the N-NO(2) bond in the side chain and verify the experimental observation that the title compound has better stability than CL-20.	Nitrous Oxide	83-87	epithelial membrane protein 1	Homo sapiens	204-209
21626863-3	2011	Analysis of knockout mice and pharmacological analysis suggest that the K -opioid receptor and the nociceptin receptor are involved in the antinociceptive effects of nitrous oxide.	Nitrous Oxide	166-179	opioid receptor-like 1	Mus musculus	99-118
20652342-3	2011	The calculations show that at both B3LYP and MP2 levels, path b is kinetically favored over path a for nitrosations by HONO and N(2)O(3).	Nitrous Oxide	128-133	tryptase pseudogene 1	Homo sapiens	45-48
20307293-4	2010	In vivo N2O accumulation rates in the mouth depended on the presence of dental plaque and on salivary NO3- concentrations.	Nitrous Oxide	8-11	NBL1, DAN family BMP antagonist	Homo sapiens	102-105
21238450-0	2011	Involvement of a NO-cyclic GMP-PKG signaling pathway in nitrous oxide-induced antinociception in mice.	Nitrous Oxide	56-69	5'-nucleotidase, cytosolic II	Mus musculus	27-30
21238450-10	2011	These results support the hypothesis that N(2)O-induced antinociception in mice is mediated by a NO-cyclic GMP-PKG pathway.	Nitrous Oxide	42-47	5'-nucleotidase, cytosolic II	Mus musculus	107-110
21273388-7	2011	A significant positive correlation between NOS2 gene expression and nNO levels was demonstrated in all children (p = 0.001; r = 0.428), and this correlation was confirmed in patients with PCD (p = 0.019; r = 0.484).	Nitrous Oxide	68-71	nitric oxide synthase 2	Homo sapiens	43-47
21273388-10	2011	nNO levels were higher in PCD subjects with the NOS3 thymidine 894 mutation, and this was associated with a higher ciliary beat frequency (p = 0.045).	Nitrous Oxide	0-3	nitric oxide synthase 3	Homo sapiens	48-52
20937263-2	2010	The present study employed microdialysis to determine whether exposure to N(2)O stimulates proopiomelanocortin (POMC) neurons to release beta-endorphin in the arcuate nucleus (ARC) of the hypothalamus and the periaqueductal gray (PAG) of the midbrain.	Nitrous Oxide	74-79	proopiomelanocortin	Rattus norvegicus	112-116
20595705-6	2010	Low levels of beta-endorphin at the end of pregnancy were associated with need for additional pain medication beyond nitrous oxide during labor, although the causal relationship is unclear.	Nitrous Oxide	117-130	proopiomelanocortin	Homo sapiens	14-28
20473251-0	2010	The correlation of nitrous oxide of nNOS and p53 during developing brain.	Nitrous Oxide	19-32	nitric oxide synthase 1	Homo sapiens	36-40
20473251-0	2010	The correlation of nitrous oxide of nNOS and p53 during developing brain.	Nitrous Oxide	19-32	tumor protein p53	Homo sapiens	45-48
20473255-0	2010	Nitrous oxide discretely up-regulates nNOS and p53 in neonatal rat brain.	Nitrous Oxide	0-13	nitric oxide synthase 1	Rattus norvegicus	38-42
20473255-0	2010	Nitrous oxide discretely up-regulates nNOS and p53 in neonatal rat brain.	Nitrous Oxide	0-13	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	47-50
21059758-0	2011	Free radical signalling underlies inhibition of CaV3.2 T-type calcium channels by nitrous oxide in the pain pathway.	Nitrous Oxide	82-95	caveolin 3	Mus musculus	48-52
21059758-2	2011	Here, we present a molecular mechanism of nitrous oxide"s selective inhibition of CaV3.2 low-voltage-activated (T-type) calcium channels in pain pathways.	Nitrous Oxide	42-55	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	82-88
21059758-3	2011	Using site-directed mutagenesis and metal chelators such as diethylenetriamine pentaacetic acid and deferoxamine, we reveal that a unique histidine at position 191 of CaV3.2 participates in a critical metal binding site, which may in turn interact with N2O to produce reactive oxygen species (ROS).	Nitrous Oxide	253-256	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	167-173
21059758-5	2011	Evidence of hydrogen peroxide and free radical intermediates is given in that N2O inhibition of CaV3.2 channels is attenuated when H2O2 is neutralized by catalase.	Nitrous Oxide	78-81	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	96-102
21059758-5	2011	Evidence of hydrogen peroxide and free radical intermediates is given in that N2O inhibition of CaV3.2 channels is attenuated when H2O2 is neutralized by catalase.	Nitrous Oxide	78-81	catalase	Mus musculus	154-162
21059758-7	2011	Ensuing in vivo studies indicate that mice lacking CaV3.2 channels display decreased analgesia to N2O in response to formalin-induced inflammatory pain.	Nitrous Oxide	98-101	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	51-57
20830937-0	2010	Denitrification: an important pathway for nitrous oxide production in tropical mangrove sediments (Goa, India).	Nitrous Oxide	42-55	tripartite motif containing 47	Homo sapiens	99-102
20473255-7	2010	To gain further insight into the events underlying neuro-apoptosis, we analyzed the transcriptional consequences of N2O exposure on nNOS, iNOS and p53 mRNA levels.	Nitrous Oxide	116-119	nitric oxide synthase 1	Rattus norvegicus	132-136
20473255-7	2010	To gain further insight into the events underlying neuro-apoptosis, we analyzed the transcriptional consequences of N2O exposure on nNOS, iNOS and p53 mRNA levels.	Nitrous Oxide	116-119	nitric oxide synthase 2	Rattus norvegicus	138-142
20473255-7	2010	To gain further insight into the events underlying neuro-apoptosis, we analyzed the transcriptional consequences of N2O exposure on nNOS, iNOS and p53 mRNA levels.	Nitrous Oxide	116-119	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	147-150
20473255-12	2010	The p53 mRNA was up-regulated almost 2-fold (P=0.0002; Student"s t-Test; GraphPad Prism 4.00) in N2O-treated samples relative to room-air samples.	Nitrous Oxide	97-100	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	4-7
20473255-13	2010	CONCLUSION: Our preliminary data show that N2O induced a selective increase in nNOS and p53 transcription.	Nitrous Oxide	43-46	nitric oxide synthase 1	Rattus norvegicus	79-83
20473255-13	2010	CONCLUSION: Our preliminary data show that N2O induced a selective increase in nNOS and p53 transcription.	Nitrous Oxide	43-46	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	88-91
20403764-11	2009	Increased levels of cleaved transferrin during sea lice infection may activate the nitrous oxide response of salmon macrophages, as part of the fish"s immune response to sea lice infection.	Nitrous Oxide	83-96	serotransferrin-1	Salmo salar	28-39
19819622-3	2010	For the series of model N-nitrocompounds it is drawn from the NBO analysis that at the UB3LYP/6-31G(**) level the order of BDE(ZPE) is not only in line with that of bond order but also with that of the energy gap between N-NO(2) bond and antibond orbitals.	Nitrous Oxide	221-225	homeobox D13	Homo sapiens	123-126
21461374-4	2010	In occupational medicine, vitamin B12 deficiency has been reported with exposure to nitrous oxide in health care workers.	Nitrous Oxide	84-97	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	34-37
19741497-6	2009	RESULTS: Treatment with a combination of 70% nitrous oxide and 1% isoflurane for 6 h induced caspase-3 activation and apoptosis in H4 naive cells and primary neurons from naive mice.	Nitrous Oxide	45-58	caspase 3	Mus musculus	93-102
19741497-7	2009	The 70% nitrous oxide plus 1% isoflurane, but neither alone, for 6 h induced caspase-3 activation and apoptosis, and increased levels of beta-site amyloid precursor protein-cleaving enzyme and Abeta in H4-amyloid precursor protein cells.	Nitrous Oxide	8-21	caspase 3	Mus musculus	77-86
19741497-7	2009	The 70% nitrous oxide plus 1% isoflurane, but neither alone, for 6 h induced caspase-3 activation and apoptosis, and increased levels of beta-site amyloid precursor protein-cleaving enzyme and Abeta in H4-amyloid precursor protein cells.	Nitrous Oxide	8-21	amyloid beta (A4) precursor protein	Mus musculus	193-198
19741497-8	2009	In addition, the nitrous oxide plus isoflurane-induced Abeta generation was reduced by a broad caspase inhibitor, Z-VAD.	Nitrous Oxide	17-30	amyloid beta (A4) precursor protein	Mus musculus	55-60
19741497-9	2009	Finally, the nitrous oxide plus isoflurane-induced caspase-3 activation was attenuated by gamma-secretase inhibitor L-685,458, but potentiated by exogenously added Abeta.	Nitrous Oxide	13-26	caspase 3	Mus musculus	51-60
19741497-9	2009	Finally, the nitrous oxide plus isoflurane-induced caspase-3 activation was attenuated by gamma-secretase inhibitor L-685,458, but potentiated by exogenously added Abeta.	Nitrous Oxide	13-26	amyloid beta (A4) precursor protein	Mus musculus	164-169
19741497-10	2009	CONCLUSION: These results suggest that the common anesthetics nitrous oxide plus isoflurane may promote neurotoxicity by inducing apoptosis and increasing Abeta levels.	Nitrous Oxide	62-75	amyloid beta (A4) precursor protein	Mus musculus	155-160
19783046-0	2009	Structural and biophysical determinants of single Ca(V)3.1 and Ca(V)3.2 T-type calcium channel inhibition by N(2)O.	Nitrous Oxide	109-114	calcium voltage-gated channel subunit alpha1 G	Homo sapiens	50-58
19783046-0	2009	Structural and biophysical determinants of single Ca(V)3.1 and Ca(V)3.2 T-type calcium channel inhibition by N(2)O.	Nitrous Oxide	109-114	caveolin 3	Homo sapiens	50-56
19783046-1	2009	We investigated the biophysical mechanism of inhibition of recombinant T-type calcium channels Ca(V)3.1 and Ca(V)3.2 by nitrous oxide (N(2)O).	Nitrous Oxide	120-133	calcium voltage-gated channel subunit alpha1 G	Homo sapiens	95-103
19783046-1	2009	We investigated the biophysical mechanism of inhibition of recombinant T-type calcium channels Ca(V)3.1 and Ca(V)3.2 by nitrous oxide (N(2)O).	Nitrous Oxide	120-133	immunoglobulin lambda variable 7-43	Homo sapiens	108-116
19783046-3	2009	In whole-cell recordings N(2)O significantly inhibited Ca(V)3.2, and - less pronounced - Ca(V)3.1.	Nitrous Oxide	25-30	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	55-97
19818753-0	2010	Antagonism of the antinociceptive effect of nitrous oxide by inhibition of enzyme activity or expression of neuronal nitric oxide synthase in the mouse brain and spinal cord.	Nitrous Oxide	44-57	nitric oxide synthase 1, neuronal	Mus musculus	108-138
19818753-13	2010	Compared to wild-type mice, nNOS knockout mice showed a 60% reduction in N(2)O-induced antinociception.	Nitrous Oxide	73-78	nitric oxide synthase 1, neuronal	Mus musculus	28-32
19841811-1	2009	The unique isolable N-heterocyclic carbene (NHC)--&gt;germanone complexes and were synthesised and structurally characterised, starting from the corresponding NHC-germylene precursors and through straightforward oxygenation with N(2)O.	Nitrous Oxide	229-234	high mobility group nucleosomal binding domain 4	Homo sapiens	20-42
19841811-1	2009	The unique isolable N-heterocyclic carbene (NHC)--&gt;germanone complexes and were synthesised and structurally characterised, starting from the corresponding NHC-germylene precursors and through straightforward oxygenation with N(2)O.	Nitrous Oxide	229-234	high mobility group nucleosomal binding domain 4	Homo sapiens	44-47
19767313-5	2009	Immunohistochemical staining was used to visualize N2O-induced c-Fos expression in the lumbar spinal cord.	Nitrous Oxide	51-54	FBJ osteosarcoma oncogene	Mus musculus	63-68
19767313-7	2009	There was also no significant difference in the analgesic effect of N2O 70% or in the level of c-Fos expression induced by N2O 70% between the two genotypes.	Nitrous Oxide	123-126	FBJ osteosarcoma oncogene	Mus musculus	95-100
19432308-2	2009	Seasonal variations of dissolved N2O concentrations (about 12 nmol x L(-1)) in the North Yellow Sea were not obvious.	Nitrous Oxide	33-36	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	0-3
19556054-11	2009	The effect of denitrification is further supported as mean groundwater NO3-N was significantly (P&lt;0.05) related to groundwater N2/Ar ratio, redox potential (Eh), dissolved O2 and N2 and was close to being significant with N2O (P=0.08).	Nitrous Oxide	225-228	NBL1, DAN family BMP antagonist	Homo sapiens	71-74
19339913-1	2009	OBJECTIVES: Oxidation of vitamin B12 by nitrous oxide leads to the inactivation of methionine synthase resulting in elevated plasma total homocysteine concentrations.	Nitrous Oxide	40-53	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	83-102
19339913-11	2009	The average increase in plasma homocysteine was 2.4 mumol/l (+28%) in all three groups indicating the expected inactivation of methionine synthase by nitrous oxide through oxidation of vitamin B12, but no genetic effect.	Nitrous Oxide	150-163	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	127-146
19178134-4	2009	The NNO analogues essentially retain the binding affinity of the NNO2 compounds, while the isosteric NC(O)H congeners have diminished potency.	Nitrous Oxide	4-7	membrane frizzled-related protein	Homo sapiens	65-69
19432308-0	2009	[Seasonal variations of fluxes and distributions of dissolved N2O in the North Yellow Sea].	Nitrous Oxide	62-65	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	1-4
19432308-3	2009	The saturations of dissolved N2O in the North Yellow Sea showed obvious seasonal variations with higher values occurring in summer and autumn and lower in spring, and the dissolved N2O of the surface water was from undersaturated to oversaturated with the water temperature gradually increasing during three cruises in Spring.	Nitrous Oxide	29-32	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	53-56
19432308-6	2009	Air-sea fluxes of dissolved N2O showed obvious seasonal variations, with the N2O fluxes of summer and autumn higher than those of spring.	Nitrous Oxide	28-31	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	4-7
19432308-6	2009	Air-sea fluxes of dissolved N2O showed obvious seasonal variations, with the N2O fluxes of summer and autumn higher than those of spring.	Nitrous Oxide	77-80	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	4-7
19432308-7	2009	Based on the average annual N2O flux and the area of the North Yellow Sea, the annual N2O emission from the studied area was estimated to be (5.3 x 10(-3) -9.2 x 10(-3)) Tg x a(-1).	Nitrous Oxide	86-89	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	70-73
19432308-8	2009	From the above results, it can be seen that the North Yellow Sea was a net source of atmospheric N2O.	Nitrous Oxide	97-100	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	61-64
19778432-0	2009	Tumor necrosis factor alpha-dependent aggrecan cleavage and release of glycosaminoglycans in the meniscus is mediated by nitrous oxide-independent aggrecanase activity in vitro.	Nitrous Oxide	121-134	tumor necrosis factor	Bos taurus	0-27
18801604-4	2009	CL-20 degradation was accompanied by the formation of formate, glyoxal, nitrite, ammonium, and nitrous oxide.	Nitrous Oxide	95-108	epithelial membrane protein 1	Homo sapiens	0-5
18580170-1	2008	BACKGROUND: Mutations in the methylenetetrahydrofolate reductase (MTHFR) gene (677C&gt;T, 1298A&gt;C) cause elevated plasma homocysteine concentrations and have been linked to fatal outcomes after nitrous oxide anesthesia.	Nitrous Oxide	197-210	methylenetetrahydrofolate reductase	Homo sapiens	29-64
18580170-1	2008	BACKGROUND: Mutations in the methylenetetrahydrofolate reductase (MTHFR) gene (677C&gt;T, 1298A&gt;C) cause elevated plasma homocysteine concentrations and have been linked to fatal outcomes after nitrous oxide anesthesia.	Nitrous Oxide	197-210	methylenetetrahydrofolate reductase	Homo sapiens	66-71
18580170-2	2008	This study tested the hypothesis that patients with common MTHFR 677C&gt;T or 1298A&gt;C mutations develop higher plasma homocysteine concentrations after nitrous oxide anesthesia than wild-type patients.	Nitrous Oxide	155-168	methylenetetrahydrofolate reductase	Homo sapiens	59-64
18580170-11	2008	CONCLUSIONS: This study shows that patients with a homozygous MTHFR 677C&gt;T or 1298A&gt;C mutation are at a higher risk of developing abnormal plasma homocysteine concentrations after nitrous oxide anesthesia.	Nitrous Oxide	186-199	methylenetetrahydrofolate reductase	Homo sapiens	62-67
18499598-6	2008	RESULTS: Isoflurane plus nitrous oxide increased the numbers of caspase-3 positive neurons in the spinal cord (P &lt; 0.01).	Nitrous Oxide	25-38	caspase 3	Rattus norvegicus	64-73
18499630-8	2008	RESULTS: Exposure to 75% N(2)O increased c-Fos expression in tyrosine hydroxylase-positive cells in the ventral tegmental area.	Nitrous Oxide	25-30	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	41-46
18499630-8	2008	RESULTS: Exposure to 75% N(2)O increased c-Fos expression in tyrosine hydroxylase-positive cells in the ventral tegmental area.	Nitrous Oxide	25-30	tyrosine hydroxylase	Rattus norvegicus	61-81
19249419-2	2009	Many receive nitrous oxide, which impairs methionine synthase, thus inhibiting folate synthesis and increasing postoperative homocysteine levels.	Nitrous Oxide	13-26	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	42-61
19340552-11	2009	(2) The recoveries of LVDP and pressure-rate product (PRP) after hypoxia-reoxygenation were better in the sevo-pre group than in the CT or N(2)O-pre group.	Nitrous Oxide	139-144	proline rich protein 2-like 1	Rattus norvegicus	54-57
19340552-12	2009	(3) Application of either sevoflurane or N(2)O during hypoxia improved recovery of LVDP and PRP, and GOT release was significantly lower than in the CT group.	Nitrous Oxide	41-46	proline rich protein 2-like 1	Rattus norvegicus	92-95
19444578-0	2009	Nociceptin receptor antagonist JTC-801 inhibits nitrous oxide-induced analgesia in mice.	Nitrous Oxide	48-61	opioid receptor-like 1	Mus musculus	0-19
19444578-2	2009	Although we have reported that the analgesic effect of N(2)O was significantly decreased in nociceptin-orphanin FQ (N/OFQ) receptor (NOP)-deficient mice, the effect of nociceptin receptor antagonists on N(2)O-induced analgesia has not been reported.	Nitrous Oxide	55-60	opioid receptor-like 1	Mus musculus	116-131
19444578-2	2009	Although we have reported that the analgesic effect of N(2)O was significantly decreased in nociceptin-orphanin FQ (N/OFQ) receptor (NOP)-deficient mice, the effect of nociceptin receptor antagonists on N(2)O-induced analgesia has not been reported.	Nitrous Oxide	55-60	crystallin, gamma B	Mus musculus	133-136
19444578-3	2009	In this investigation, we examined the effect of the NOP antagonist JTC-801 on N(2)O-induced analgesia in 129Sv mice by the writhing test and tail flick test, and demonstrated that the analgesic effect of N(2)O was suppressed by the intraperitoneal administration of JTC-801.	Nitrous Oxide	79-84	crystallin, gamma B	Mus musculus	53-56
19444578-3	2009	In this investigation, we examined the effect of the NOP antagonist JTC-801 on N(2)O-induced analgesia in 129Sv mice by the writhing test and tail flick test, and demonstrated that the analgesic effect of N(2)O was suppressed by the intraperitoneal administration of JTC-801.	Nitrous Oxide	205-210	crystallin, gamma B	Mus musculus	53-56
18074162-9	2008	One month of CPAP therapy increased pH (p &lt; 0.05) and reduced eNO (p &lt; 0.001) and nNO (p &lt; 0.05).	Nitrous Oxide	88-91	centromere protein J	Homo sapiens	13-17
18605556-5	2008	When either of the reduced RDX products (MNX or TNX) was treated with ZVINs we observed nitrite (from MNX only), NO (from TNX only), N2O, NH4+, NH2NH2 and HCHO.	Nitrous Oxide	133-136	keratin 86	Homo sapiens	41-44
18605556-5	2008	When either of the reduced RDX products (MNX or TNX) was treated with ZVINs we observed nitrite (from MNX only), NO (from TNX only), N2O, NH4+, NH2NH2 and HCHO.	Nitrous Oxide	133-136	tenascin XA (pseudogene)	Homo sapiens	48-51